KR20250005425A - Fviii-bdd 및 이종의 신호 펩타이드에 기반한 융합 단백질을 인코딩하는 단리된 핵산 - Google Patents
Fviii-bdd 및 이종의 신호 펩타이드에 기반한 융합 단백질을 인코딩하는 단리된 핵산 Download PDFInfo
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C07K14/745—Blood coagulation or fibrinolysis factors
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
Landscapes
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| RU2022111695 | 2022-04-28 | ||
| RU2022111695A RU2818229C2 (ru) | 2022-04-28 | Выделенная нуклеиновая кислота, которая кодирует слитый белок на основе FVIII-BDD и гетерологичного сигнального пептида, и ее применение | |
| PCT/RU2023/050093 WO2023211315A1 (en) | 2022-04-28 | 2023-04-18 | Isolated nucleic acid that encodes fusion protein based on fviii-bdd and on heterologous signal peptide |
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| KR20250005425A true KR20250005425A (ko) | 2025-01-09 |
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| CN120365434A (zh) * | 2024-01-23 | 2025-07-25 | 上海苹谱医疗科技有限公司 | 一种提高凝血因子ⅷ分泌水平的双信号肽及其应用 |
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| PL3326643T3 (pl) * | 2009-12-06 | 2021-10-25 | Bioverativ Therapeutics Inc. | Chimeryczne i hybrydowe polipeptydy czynnika VIII-FC oraz sposoby ich zastosowania |
| JP2016519110A (ja) * | 2013-04-22 | 2016-06-30 | キャタレント ファーマ ソリューションズ リミテッド ライアビリティ カンパニー | 獣医学的デコリン組成物及びそれらの使用 |
| RU2647769C2 (ru) * | 2015-12-30 | 2018-03-19 | Закрытое Акционерное Общество "Биокад" | Химерный улучшенный рекомбинантный фактор VIII |
| WO2017136358A1 (en) * | 2016-02-01 | 2017-08-10 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
| CN114651065B (zh) * | 2019-09-03 | 2024-08-20 | 五松尖端医疗产业振兴财团 | 导入用于提高蛋白质生产性的单个条形码系统的信号肽超高速筛选方法 |
| EP4051704A2 (en) * | 2019-11-01 | 2022-09-07 | Freeline Therapeutics Limited | Factor viii construct |
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| PY2331055A (es) | 2023-12-05 |
| TW202342751A (zh) | 2023-11-01 |
| WO2023211315A1 (en) | 2023-11-02 |
| MA68435A1 (fr) | 2025-04-30 |
| MX2024013281A (es) | 2024-12-06 |
| AR129164A1 (es) | 2024-07-24 |
| CO2024014703A2 (es) | 2024-12-30 |
| CL2024003295A1 (es) | 2025-02-21 |
| CN117402901A (zh) | 2024-01-16 |
| CA3250663A1 (en) | 2023-11-02 |
| IL316578A (en) | 2024-12-01 |
| PE20251064A1 (es) | 2025-04-09 |
| JOP20240240A1 (ar) | 2024-10-27 |
| AU2023261711A1 (en) | 2024-11-21 |
| UY40243A (es) | 2023-11-15 |
| JP2025515356A (ja) | 2025-05-14 |
| CR20240525A (es) | 2025-03-05 |
| EP4514975A1 (en) | 2025-03-05 |
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