KR20240149414A - 올리고뉴클레오티드의 제조 방법 - Google Patents

올리고뉴클레오티드의 제조 방법 Download PDF

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Publication number
KR20240149414A
KR20240149414A KR1020247029378A KR20247029378A KR20240149414A KR 20240149414 A KR20240149414 A KR 20240149414A KR 1020247029378 A KR1020247029378 A KR 1020247029378A KR 20247029378 A KR20247029378 A KR 20247029378A KR 20240149414 A KR20240149414 A KR 20240149414A
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KR
South Korea
Prior art keywords
nucleoside
amount
phosphoroamidite
activator
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247029378A
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English (en)
Korean (ko)
Inventor
케이 요시다
토모요시 이다
마사푸미 이와모토
에리 매타
준 마츠나미
Original Assignee
닛토덴코 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 닛토덴코 가부시키가이샤 filed Critical 닛토덴코 가부시키가이샤
Publication of KR20240149414A publication Critical patent/KR20240149414A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
KR1020247029378A 2022-02-04 2023-02-06 올리고뉴클레오티드의 제조 방법 Pending KR20240149414A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2022016004 2022-02-04
JPJP-P-2022-016004 2022-02-04
JPJP-P-2022-142047 2022-09-07
JP2022142047 2022-09-07
PCT/JP2023/003685 WO2023149563A1 (ja) 2022-02-04 2023-02-06 オリゴヌクレオチドを製造する方法

Publications (1)

Publication Number Publication Date
KR20240149414A true KR20240149414A (ko) 2024-10-14

Family

ID=87552616

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247029378A Pending KR20240149414A (ko) 2022-02-04 2023-02-06 올리고뉴클레오티드의 제조 방법

Country Status (5)

Country Link
US (1) US20250136635A1 (https=)
EP (1) EP4474387A4 (https=)
JP (1) JPWO2023149563A1 (https=)
KR (1) KR20240149414A (https=)
WO (1) WO2023149563A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025165064A1 (ko) * 2024-02-02 2025-08-07 에스티팜 주식회사 올리고뉴클레오티드 합성을 위한 개선된 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060022323A (ko) 2004-09-07 2006-03-10 한국건설기술연구원 합성바닥판 연결방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
KR20220062517A (ko) * 2019-08-15 2022-05-17 아이오니스 파마수티컬즈, 인코포레이티드 결합 변형된 올리고머 화합물 및 이의 용도

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060022323A (ko) 2004-09-07 2006-03-10 한국건설기술연구원 합성바닥판 연결방법

Also Published As

Publication number Publication date
JPWO2023149563A1 (https=) 2023-08-10
US20250136635A1 (en) 2025-05-01
WO2023149563A1 (ja) 2023-08-10
EP4474387A4 (en) 2025-09-24
EP4474387A1 (en) 2024-12-11

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20240830

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application