KR20240130128A - 항-cd84 항체 및 키메라 항원 수용체 - Google Patents

항-cd84 항체 및 키메라 항원 수용체 Download PDF

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Publication number
KR20240130128A
KR20240130128A KR1020247025889A KR20247025889A KR20240130128A KR 20240130128 A KR20240130128 A KR 20240130128A KR 1020247025889 A KR1020247025889 A KR 1020247025889A KR 20247025889 A KR20247025889 A KR 20247025889A KR 20240130128 A KR20240130128 A KR 20240130128A
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South Korea
Prior art keywords
seq
variant
amino acid
deletions
cdr2
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Pending
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KR1020247025889A
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English (en)
Korean (ko)
Inventor
넬라 클라인 곤잘레스
마누엘 후안 오테로
라몬 빌렐라 푸이그
로레나 페레즈 아밀
클라우디오 호아오 리베이로 도스 산토스
Original Assignee
기알라 테라퓨틱스 소시에다드 리미타다
호스피탈 크리닉 드 바르셀로나
푼다시오 데 레세르카 클리닉 바르셀로나-인스티튜트 디＇인베스티가시온스 바이오메디케스 아우구스트 피 아이 수니에르
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Priority claimed from EP22382003.6A external-priority patent/EP4209511A1/en
Application filed by 기알라 테라퓨틱스 소시에다드 리미타다, 호스피탈 크리닉 드 바르셀로나, 푼다시오 데 레세르카 클리닉 바르셀로나-인스티튜트 디＇인베스티가시온스 바이오메디케스 아우구스트 피 아이 수니에르 filed Critical 기알라 테라퓨틱스 소시에다드 리미타다
Publication of KR20240130128A publication Critical patent/KR20240130128A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A61K39/4611—
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4217—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/11—Antigen recognition domain
    • A61K2239/13—Antibody-based
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/21—Transmembrane domain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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KR1020247025889A 2022-01-05 2023-01-05 항-cd84 항체 및 키메라 항원 수용체 Pending KR20240130128A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22382003.6 2022-01-05
EP22382003.6A EP4209511A1 (en) 2022-01-05 2022-01-05 Anti-cd84 antibodies amd chimeric antigen receptors
EP22205399 2022-11-03
EP22205399.3 2022-11-03
PCT/EP2023/050194 WO2023131657A1 (en) 2022-01-05 2023-01-05 Anti-cd84 antibodies and chimeric antigen receptors

Publications (1)

Publication Number Publication Date
KR20240130128A true KR20240130128A (ko) 2024-08-28

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ID=84982030

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KR1020247025889A Pending KR20240130128A (ko) 2022-01-05 2023-01-05 항-cd84 항체 및 키메라 항원 수용체

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US (1) US20250064853A1 (https=)
EP (1) EP4460519B1 (https=)
JP (1) JP2025500618A (https=)
KR (1) KR20240130128A (https=)
AU (1) AU2023205629A1 (https=)
CA (1) CA3242498A1 (https=)
IL (1) IL313971A (https=)
MX (1) MX2024008495A (https=)
WO (1) WO2023131657A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025113635A1 (zh) * 2023-12-01 2025-06-05 上海祥耀生物科技有限责任公司 抗cd84抗体及其用途
WO2026029044A1 (ja) * 2024-07-30 2026-02-05 学校法人藤田学園 うつ病または統合失調症の診断などを補助する方法、キットおよびバイオマーカー

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT904392E (pt) 1996-10-17 2001-06-29 Oxford Biomedica Ltd Vectores retrovirais
GB9803351D0 (en) 1998-02-17 1998-04-15 Oxford Biomedica Ltd Anti-viral vectors
GB0009760D0 (en) 2000-04-19 2000-06-07 Oxford Biomedica Ltd Method
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
CN106573976B (zh) * 2014-02-06 2020-05-05 耶达研究及发展有限公司 抗cd84抗体、包含所述抗体的组合物及其用途
US20220372159A1 (en) * 2019-07-01 2022-11-24 Julius-Maximilians-Universitaet-Wuerzburg Treatment and Prevention of Ischemic Diseases And/Or Ischemic Tissue Damages

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US20250064853A1 (en) 2025-02-27
CA3242498A1 (en) 2023-07-13
EP4460519B1 (en) 2026-03-11
JP2025500618A (ja) 2025-01-09
WO2023131657A1 (en) 2023-07-13
EP4460519A1 (en) 2024-11-13
AU2023205629A1 (en) 2024-08-15
IL313971A (en) 2024-08-01
MX2024008495A (es) 2024-09-04

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