KR20240082371A - 이미다조피리다진 il-17 억제제 화합물 - Google Patents

이미다조피리다진 il-17 억제제 화합물 Download PDF

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Publication number
KR20240082371A
KR20240082371A KR1020247013538A KR20247013538A KR20240082371A KR 20240082371 A KR20240082371 A KR 20240082371A KR 1020247013538 A KR1020247013538 A KR 1020247013538A KR 20247013538 A KR20247013538 A KR 20247013538A KR 20240082371 A KR20240082371 A KR 20240082371A
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KR
South Korea
Prior art keywords
alkyl
cycloalkyl
substituted
pharmaceutically acceptable
compound
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Pending
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KR1020247013538A
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English (en)
Korean (ko)
Inventor
스티븐 디. 골드버그
딘 골든
스티븐 에이. 로스콧
스테판 맥카버
스티븐 피. 메두나
브록 티. 샤이먼
알렉산더 이. 발데스
동페이 우
시아오후아 슈에
루크 이. 한나
제니퍼 디. 베너블
더글러스 씨. 비헤나
Original Assignee
얀센 파마슈티카 엔브이
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Application filed by 얀센 파마슈티카 엔브이 filed Critical 얀센 파마슈티카 엔브이
Publication of KR20240082371A publication Critical patent/KR20240082371A/ko
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020247013538A 2021-09-27 2022-09-26 이미다조피리다진 il-17 억제제 화합물 Pending KR20240082371A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163248563P 2021-09-27 2021-09-27
US63/248,563 2021-09-27
US202163273407P 2021-10-29 2021-10-29
US63/273,407 2021-10-29
US202263371910P 2022-08-19 2022-08-19
US63/371,910 2022-08-19
PCT/US2022/077000 WO2023049886A1 (en) 2021-09-27 2022-09-26 Imidazopyridazine il-17 inhibitor compounds

Publications (1)

Publication Number Publication Date
KR20240082371A true KR20240082371A (ko) 2024-06-10

Family

ID=83693127

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247013538A Pending KR20240082371A (ko) 2021-09-27 2022-09-26 이미다조피리다진 il-17 억제제 화합물

Country Status (10)

Country Link
US (2) US12215111B2 (https=)
EP (1) EP4408529A1 (https=)
JP (1) JP2024536863A (https=)
KR (1) KR20240082371A (https=)
AU (1) AU2022348938A1 (https=)
CA (1) CA3233625A1 (https=)
MX (1) MX2024003770A (https=)
TW (1) TW202329933A (https=)
UY (1) UY39957A (https=)
WO (1) WO2023049886A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240082371A (ko) 2021-09-27 2024-06-10 얀센 파마슈티카 엔브이 이미다조피리다진 il-17 억제제 화합물
TW202430165A (zh) 2022-12-02 2024-08-01 丹麥商理奧藥品公司 Il-17之小分子調節劑
WO2024138286A1 (en) * 2022-12-26 2024-07-04 Usynova Pharmaceuticals, Ltd. Il-17a modulators
WO2024163365A1 (en) * 2023-01-30 2024-08-08 Dice Alpha, Inc. Benzimidazole and aza-benzimidazole based il-17a modulators and uses thereof
CN121311483A (zh) * 2023-03-28 2026-01-09 詹森药业有限公司 含内酰胺的咪唑并哒嗪il-17抑制剂化合物
WO2025202922A1 (en) * 2024-03-27 2025-10-02 Janssen Pharmaceutica Nv Imidazopyridazine il-17 inhibitor compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI752400B (zh) * 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
GB201909190D0 (en) * 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
KR20230019507A (ko) 2020-04-30 2023-02-08 얀센 파마슈티카 엔.브이. Il-17의 조절제로서의 이미다조피리다진
WO2023025783A1 (en) 2021-08-23 2023-03-02 Leo Pharma A/S Small molecule modulators of il-17
KR20240082371A (ko) 2021-09-27 2024-06-10 얀센 파마슈티카 엔브이 이미다조피리다진 il-17 억제제 화합물
CN116143777A (zh) 2021-11-04 2023-05-23 四川海思科制药有限公司 一种可抑制il-17a的杂环化合物及其用途
TW202413363A (zh) 2021-11-04 2024-04-01 大陸商西藏海思科製藥有限公司 一種可抑制il-17a之雜環化合物及其用途

Also Published As

Publication number Publication date
US12215111B2 (en) 2025-02-04
MX2024003770A (es) 2024-06-19
CA3233625A1 (en) 2023-03-30
US20230147458A1 (en) 2023-05-11
UY39957A (es) 2023-04-14
EP4408529A1 (en) 2024-08-07
WO2023049886A1 (en) 2023-03-30
AU2022348938A1 (en) 2024-05-16
TW202329933A (zh) 2023-08-01
US20250206744A1 (en) 2025-06-26
JP2024536863A (ja) 2024-10-08

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20240423

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application