KR20240013317A - Polyolefin-based eco-friendly tube composition with excellent necking deformation prevention and flexibility, and eco-friendly infusion set manufactured using the same - Google Patents

Abstract

The polyolefin-based eco-friendly tube composition of the present specification includes 40 to 85% by weight of ultra-low density polyethylene; 10 to 50% by weight of polyethylene-based elastomer; and 5 to 10% by weight of linear low density polyethylene.

Description

Polyolefin-based eco-friendly tube composition with excellent necking deformation prevention and flexibility, and eco-friendly infusion set manufactured using the same}

The present invention relates to an eco-friendly tube composition and an eco-friendly IV solution set manufactured using the same. More specifically, an eco-friendly tube composition of the polyolefin (hereinafter referred to as 'PO') series, characterized by excellent necking deformation prevention and flexibility, and This relates to an eco-friendly sap set manufactured using this.

Conventionally, soft polyvinyl chloride (PVC) containing a large amount of plasticizers such as diethylhexyl phthalate has been widely used as molded tubes for medical purposes due to its excellent flexibility and compatibility with infusion pumps and its low price.

However, soft PVC tubes not only have the problem of adsorption of drugs to the tube when administering drugs such as medical fluids and sedatives such as nitroglycerin and diazepam, but also have the problem that plasticizers are eluted from the tube when drugs containing surfactants are administered, causing damage to the human endocrine system. It can cause serious problems, such as acting as a so-called environmental hormone that causes disturbance.

In addition, when polyurethane (PU) material is introduced into medical tubes, etc., the problem of dissolution of existing plasticizers is resolved, but polyurethane (PU) also has high adsorption to drugs, so a precise amount of drug is administered to the patient. There is a problem that is difficult to solve.

Due to the above-mentioned problems, polyolefin (PO)-based sap sets have recently been developed as an alternative to soft PVC and PU.

However, even in the case of PO-based infusion sets, drug non-adsorption is excellent, but there is a possibility that necking may occur due to the polyolefin elastomer (POE) component added to provide a certain flexibility to the infusion tube. This increases again.

The necking phenomenon referred to herein may mean a phenomenon in which the inner diameter and outer diameter of the tube become smaller due to the tensile force applied to the infusion tube.

Specifically, when using an infusion tube in which a necking phenomenon occurs due to the infusion tube being caught in an obstacle or stretched by an artificial force, a problem arises in which it is difficult to inject an accurate amount of drug.

Polyolefin (PO) referred to herein refers to a polymer compound such as polyethylene (PE) or polypropylene (PP) polymerized from ethylene monomer (monomer) or propylene monomer.

Polyolefin (PO) has high hardness and is not suitable for use as an infusion tube. However, by adding a large amount of polyolefin-based elastomer (POE) to polyolefin (PO), a flexible infusion tube with low hardness can be obtained.

Meanwhile, when manufacturing an infusion tube using polyolefin (PO), it is necessary to consider the inverse tendency between the flexibility of the infusion tube and the necking phenomenon.

In other words, as the hardness of the infusion tube decreases, the possibility of the necking phenomenon occurring increases, and as the hardness of the infusion tube increases, the possibility of the necking phenomenon occurring decreases.

Currently, an eco-friendly PO-based infusion tube that prevents necking and has excellent flexibility has not been developed.

As a conventional proposal, reference can be made to Republic of Korea Patent No. 10-1068117, which mentions 'polyvinyl chloride-free medical tubes, molded parts and medical supplies manufactured therefrom'.

The purpose of the present specification is to provide a polyolefin-based eco-friendly tube composition characterized by excellent flexibility and prevention of necking deformation, and an eco-friendly IV solution set manufactured using the same.

The technical problems to be achieved through this specification are not limited to the technical problems mentioned above, and other technical problems not mentioned can be clearly understood by those skilled in the art from the description below. You will be able to.

The polyolefin-based eco-friendly tube composition according to this embodiment includes 40 to 85% by weight of Very Low Density Polyethylene (VLDPE); and 10 to 50% by weight of polyolefin-based elastomer; And 5 to 10% by weight of linear low density polyethylene (LLDPE).

According to this embodiment, very low density polyethylene (VLDPE) is polymerized under a metallocene catalyst and is made from the group containing at least one α-olefin selected from ethylene, propylene, 1-butene, 1-hexene, and 1-octene. It is characterized in that it is a mixture of one or more selected substances.

According to this embodiment, the melt index (g/10 min) of very low density polyethylene (VLDPE) is 1 to 10 at 190°C and a load of 2.16 kg.

According to this embodiment, the polyolefin-based elastomer (POE) has an ethylene content of 70 to 95% by weight, propylene, 1-butene, 1-pentene, 1-hexene, 1-heptene, 1-octene, and 1-nonene. , characterized in that it is a mixture of at least one selected from the group consisting of ethylene-α-olefin copolymer-based elastomers containing 5 to 30% by weight of at least one ethylene-α-olefin selected from 1-decene and 1-dodecene.

According to this embodiment, the melt index (g/10 min) of the polyolefin-based elastomer (POE) is 1 to 10 at 190°C and a load of 2.16 kg.

According to one embodiment, the linear low density polyethylene (LLDPE) is selected from propylene, 1-butene, 1-pentene, 1-hexene, 1-heptene, 1-octene, 1-nonene, 1-decene, and 1-dodecene. It is characterized in that it contains at least one ethylene-α-olefin.

According to this embodiment, the melt index (g/10 min) of linear low density polyethylene (LLDPE) is 0.1 to 10 at 190°C and a load of 2.16 kg.

According to this embodiment, the polyolefin-based eco-friendly tube composition has a hardness of 70 to 90 Shore A.

According to this embodiment, the polyolefin-based eco-friendly tube composition has a flexural modulus of elasticity of 200 MPa or less.

According to this embodiment, the yield tensile strength of the infusion tube manufactured from the polyolefin-based eco-friendly tube composition is characterized in that it is 7.0 MPa or more.

According to this embodiment, the hardness of the IV tube manufactured from the polyolefin-based eco-friendly tube composition is 70 to 90 Shore A.

According to an embodiment of the present specification, a polyolefin-based eco-friendly tube composition characterized by excellent flexibility and prevention of necking deformation of the infusion tube and an eco-friendly infusion set manufactured using the same can be provided.

Figure 1 is a view showing a cross-section of an IV tube containing a polyolefin-based eco-friendly tube composition with excellent necking deformation prevention and flexibility according to this embodiment.
Figure 2 is a diagram showing the components of an eco-friendly infusion solution set using a tube composition with excellent necking deformation prevention and flexibility according to this embodiment.
Figure 3 shows a stress-strain curve associated with a tube composition that prevents necking deformation and has excellent flexibility according to an embodiment of the present invention.

The above-described characteristics and the detailed description below are all exemplary matters to aid description and understanding of the present specification. That is, the present specification is not limited to this embodiment and may be embodied in other forms. The following embodiments are merely examples for completely disclosing the present specification, and are intended to convey the present specification to those skilled in the art to which the present specification pertains. Therefore, when there are multiple methods for implementing the components of the present specification, it is necessary to clarify that the present specification can be implemented using any of these methods, either a specific method or one that is equivalent to the method.

In this specification, when it is mentioned that a certain configuration includes specific elements or that a process includes specific steps, it means that other elements or other steps may be further included. That is, the terms used in this specification are only for describing specific embodiments and are not intended to limit the concept of this specification. Furthermore, examples described to aid understanding of the invention also include complementary embodiments thereof.

The terms used in this specification have meanings commonly understood by those skilled in the art to which this specification pertains. Commonly used terms should be interpreted with consistent meaning according to the context of this specification. Additionally, terms used in this specification should not be interpreted in an overly idealistic or formal sense unless their meaning is clearly defined. Hereinafter, embodiments of the present specification will be described through the attached drawings.

Polyethylene (PE) referred to herein can be distinguished using density.

For example, a density range of 0.941 to 0.965 g/cm ³ is High Density Polyethylene (HDPE), and a density range of 0.925 to 0.94 g/cm ³ is Medium Density Polyethylene (MDPE). '), the density range of 0.915 to 0.925 g/cm ³ can be classified as low density polyethylene (hereinafter 'LDPE').

In addition, the density range of 0.91 to 0.94 g/cm ³ is Linear Low-Density Polyethylene (LLDPE), and the density range of 0.88 to 0.90 g/cm ³ is Very-Low-Density Polyethylene (Very-Low-Density Polyethylene). , hereinafter ‘VLDPE’).

Figure 1 is a view showing a cross-section of an IV tube containing a polyolefin-based eco-friendly tube composition with excellent necking deformation prevention and flexibility according to this embodiment.

Referring to FIG. 1, the infusion tube 100 according to this embodiment may include a single layer 10.

For example, the single layer 10 of FIG. 1 includes 40 to 85% by weight of very low density polyethylene (VLDPE), 10 to 50% by weight of polyethylene-based elastomer (POE), and 5 to 10% by weight of linear low density polyethylene (LLDPE). ) A tube composition containing a may be included.

The yield tensile strength of the solid mixture resin associated with the tube composition according to this embodiment may preferably have physical properties of 7 MPa or more.

Additionally, it will be understood that the better the necking strain and flexibility of the tube composition according to this embodiment, the more advantageous it may be for manufacturing the medical tube and one or more medical parts (eg, drip tube) according to the present specification.

It will be understood that Table 1 below is only an example for detailed description of the present specification, and that the present specification is not limited thereto. In addition, it will be understood that the processing in the Examples and Comparative Examples in Table 1 below was carried out in the same manner as in Example 1 unless there were special limitations.

Meanwhile, the mixture was prepared according to the content described in the Examples and Comparative Examples using a twin-screw extruder according to the mixture resin preparation example below, and the sample prepared according to the tube preparation example was manufactured into an infusion tube.

Mixture resin manufacturing example

Very low density polyethylene (VLDPE), polyethylene elastomer (POE), and linear low density polyethylene (LLDPE) are prepared in predetermined ratios and then placed into the hopper of a twin screw extruder.

The mixture resin melted and kneaded through a twin screw extruder is cooled through a cooling water tank, and can finally be obtained as solid mixture resin pellets through a pelletizer.

Meanwhile, in this specification, hardness and flexural modulus, which are flexibility evaluation items in the solid mixture resin state, were evaluated as follows.

Test method - hardness

The solid mixture resin prepared for the Examples and Comparative Examples in Table 1 below was used to prepare a 6 mm thick sheet using a hot press, and the test result was measured after 15 seconds using a Shore A hardness tester according to the ASTM D 2240 standard. The hardness was measured, and the reference point of the characteristic is considered to be appropriate for use as an infusion tube if it is within 70 to 90 Shore A.

Test method - Flexural modulus

For the Examples and Comparative Examples in Table 1 below, 3.2 mm thick bar specimens were manufactured using an injection molding machine using the solid mixture resin, and the flexural modulus was measured according to the ASTM D 790 standard, and the reference point for the properties was 200 MPa. If it is below this level, it is considered appropriate for use as an infusion tube.

Infusion tube manufacturing example

The solid mixture resin obtained through a twin screw extruder can be manufactured into an infusion tube through a single screw extruder. The tube size was extruded to have the same inner and outer diameters as the commonly used PVC IV set, and the inner diameter of the extruded tube was 2.60 to 2.80 mm and the outer diameter was 4.20 to 4.4 mm.

Meanwhile, the yield tensile strength and necking strain in the tube state were evaluated as follows.

Test method - Yield tensile strength

For the infusion tube test pieces (total length: 15 cm/gauge distance: 5 cm) prepared for the examples and comparative examples in Table 1 below, a tensile speed of 200 mm/min and measurement temperature were measured using a universal testing machine (UTM, Instron). The yield tensile strength (MPa) of the sample was measured under 23°C conditions, and the reference point for the characteristic is considered to be appropriate for use as an infusion tube if it is 7 MPa or higher.

The yield tensile strength referred to herein is related to the stress at the upper yield point in Figure 3, which is the point where the plastic region begins, and may also be referred to as tensile strength at yield or yield strength. there is.

Test method - necking strain

For the infusion tube test specimens manufactured according to the Examples and Comparative Examples in Table 1 below, the same equipment and measurement conditions as for the yield tensile strength were used, but the test was stopped when the tensile distance reached 100 mm, the specimen was removed, and the central part of the tube was Changes in the inner and outer diameters were measured.

Specifically, the reference point for determining the necking strain rate is the size (L) of the initial inner diameter of the IV tube before the test (e.g., 100 in FIG. 1) compared to the size (L) of the initial inner diameter of the IV tube (e.g., 100 in FIG. 1) before the test when the tensile distance reaches 100 mm. 100), if the strain rate of the inner diameter size (L') was within 5% (e.g., 3.5%), it was judged to be a pass, and if it was more than 5% (e.g., 7%), it was judged to be a failure.

It will be understood that the necking strain referred to herein can be obtained through the calculation of -[(L'-L)/L]*100.

It will be understood that the test methods for hardness, flexural modulus, yield tensile strength, and necking strain mentioned in this specification are only examples, and this specification is not limited thereto.

Example 1

A PO-based eco-friendly IV solution tube was manufactured according to the mixture resin manufacturing example and the IV tube manufacturing example.

Specifically, according to the predetermined specific gravity in Example 1, 85% by weight of VLDPE, 10% by weight of POE, and 5% by weight of LLDPE may be included.

The hardness and flexural modulus of the mixture resin according to Example 1 and the yield tensile strength and necking strain of the infusion tube of the single tube structure were measured by the above method, and the results are shown in Table 1 below.

Example 2

A solid mixture resin for the tube composition is obtained in the same manner as in Example 1, but in Example 2, 70% by weight of VLDPE, 20% by weight of POE, and 10% by weight of LLDPE may be included according to the predetermined specific gravity.

The hardness and flexural modulus of the mixture resin according to Example 2 and the yield tensile strength and necking strain of the infusion tube of the single tube structure were measured by the above method, and the results are shown in Table 1 below.

Example 3

A solid mixture resin for the tube composition is obtained in the same manner as in Example 1, but in Example 3, 40% by weight of VLDPE, 50% by weight of POE, and 10% by weight of LLDPE may be included according to the predetermined specific gravity.

The hardness and flexural modulus of the mixture resin according to Example 3, and the yield tensile strength and necking strain of the infusion tube of the single tube structure were measured by the above method, and the results are shown in Table 1 below.

Comparative Example 1

A solid mixture resin for a tube composition is obtained in the same manner as in Example 1, but 90% by weight of VLDPE and 10% by weight of LLDPE may be included according to the predetermined specific gravity in Comparative Example 1.

The hardness and flexural modulus of the mixture resin according to Comparative Example 1 and the yield tensile strength and necking strain of the infusion tube of the single tube structure were measured by the above method, and the results are shown in Table 1 below.

Comparative Example 2

A solid mixture resin for a tube composition is obtained in the same manner as in Example 1, but in Comparative Example 2, 30% by weight of VLDPE, 60% by weight of POE, and 10% by weight of LLDPE may be included according to a predetermined specific gravity.

The hardness and flexural modulus of the mixture resin according to Comparative Example 2 and the yield tensile strength and necking strain of the infusion tube of the single tube structure were measured by the above method, and the results are shown in Table 1 below.

Comparative Example 3

A solid mixture resin for a tube composition is obtained in the same manner as in Example 1, but in Comparative Example 3, 95% by weight of POE and 5% by weight of LLDPE may be included according to a predetermined specific gravity.

The hardness and flexural modulus of the mixture resin according to Comparative Example 3, and the yield tensile strength and necking strain of the infusion tube of the single tube structure were measured by the above method, and the results are shown in Table 1 below.

Comparative Example 4

A solid mixture resin for a tube composition is obtained in the same manner as in Example 1, but in Comparative Example 4, 60% by weight of POE and 40% by weight of LLDPE may be included according to a predetermined specific gravity.

The hardness and flexural modulus of the mixture resin according to Comparative Example 4, and the yield tensile strength and necking strain of the infusion tube of the single tube structure were measured by the above method, and the results are shown in Table 1 below.

Comparative Example 5

A solid mixture resin for a tube composition is obtained in the same manner as in Example 1, but in Comparative Example 5, only 100% by weight of PVC may be included according to a predetermined specific gravity.

The hardness and flexural modulus of the mixture resin according to Comparative Example 5 and the yield tensile strength and necking strain of the infusion tube of the single tube structure were measured by the above method, and the results are shown in Table 1 below.

Referring to Table 1, Examples 1 to 3 not only have a yield tensile strength of 7 MPa or more suitable for use as an infusion tube, but also a shore hardness of 90 or less, a flexural modulus of 200 MPa or less, and a necking strain of 5% or less. Shows excellent results that satisfy everyone,

In the end, it will be understood that the polyolefin-based eco-friendly tube composition according to Examples 1 to 3 can be preferably applied to the eco-friendly IV tube and IV set according to the present specification.

In the case of the infusion tube manufactured according to Comparative Example 1, as POE was not added, the Shore hardness was as high as 93 and the flexural modulus was 380 MPa, which resulted in a problem of reduced flexibility of the infusion tube.

In the case of the infusion tube manufactured according to Comparative Example 2 and Comparative Example 3, the yield tensile strength of the infusion tube is below the standard value and the necking deformation rate is poor, making it unsuitable for application as an actual medical infusion set.

Referring to Table 1, it will be appreciated that there is an inverse trend between yield tensile strength and necking strain.

For example, in the case of a sap tube having a high yield tensile strength, the necking strain rate of the sap tube is small. On the contrary, in the case of a sap tube having a small yield tensile strength, the necking strain rate of the sap tube shows a large characteristic.

In the case of the infusion tube manufactured according to Comparative Example 4, the yield tensile strength and necking strain were satisfied due to the addition of an excessive amount of LLDPE, but the shore hardness increased to 95 and the flexural modulus did not meet the standard values of 550 MPa, so the infusion tube Because its flexibility is not good, it is not suitable for application in actual medical fluid sets.

The infusion tube manufactured according to Comparative Example 5 can be understood as a case in which conventionally used soft PVC was applied alone. In this case, the yield tensile strength, shore hardness, flexural modulus, and necking strain were all satisfied, but as mentioned in Table 1, there was a problem with dissolution of the DEHP plasticizer contained in a certain amount in PVC, making it unsuitable for application as an actual medical IV set. .

In summary, when using the polyolefin-based eco-friendly tube composition according to Examples 1 to 3, since it does not contain any PVC plasticizer, it is not only completely free from the problem of plasticizer elution due to the use of existing soft PVC, but also can be used alone with conventionally used soft PVC. It will be understood that it exhibits characteristics equivalent to those of the infusion tube applied as.

In other words, in the case of the infusion tube manufactured using the polyolefin-based eco-friendly tube composition according to Examples 1 to 3, not only is it easy to prevent necking deformation due to improved yield tensile strength, but it is also essential for the use and management of the infusion tube. A polyolefin-based eco-friendly tube composition that satisfies the required flexural modulus (i.e., ensures flexibility) can be provided.

Meanwhile, the infusion tube 100 in FIG. 1 is shown as having a single layer 10, but it will be understood that the present specification is not limited thereto, and the tube composition according to this embodiment may also be applied to a multilayer structure. .

Figure 2 is a diagram showing the components of an eco-friendly IV solution set using a polyolefin-based eco-friendly tube composition with excellent necking deformation prevention and flexibility according to this embodiment.

Referring to Figures 1 and 2, the transfusion set of Figure 2 can be understood as a device for transporting the chemical solution from the transfusion container to the patient's body.

For example, the infusion set of Figure 2 includes a protective cover (1), an introduction needle (2), an air suction device (3), a drip tube (4), a drip container (5), an infusion tube (6), and a flow rate regulator ( 7), it may include a chemical injection part (8), a filter (9), a fitting pipe (10), a male joint (11), and a liquid needle (12). However, the components of the infusion set may be configured differently depending on the purpose of use.

It will be understood that the polyolefin-based eco-friendly tube composition according to the present embodiment described above can be applied when manufacturing not only the infusion tube (6) but also the drip tube (4) and the drip tube (5).

Figure 3 shows a stress-strain curve associated with a tube composition that prevents necking deformation and has excellent flexibility according to an embodiment of the present invention.

Referring to FIGS. 1 to 3, the stress-strain curve of FIG. 3 may be a graph related to the length that the material stretches when pulled at both ends of the material.

The x-axis of the stress-strain curve in FIG. 3 may correspond to strain, which is the ratio of the length by which the material is stretched, and the y-axis may correspond to stress, which is the force per unit area pulled to both ends of the material.

For example, the elastic region in FIG. 3 can be understood as a region that returns to its original length when stress is removed from the material. Additionally, the plastic area in FIG. 3 can be understood as an area that does not return to its original length even when stress is removed, but becomes permanently deformed and becomes larger than the original length.

The yield tensile strength referred to herein may be related to the stress at the upper yield point in FIG. 3, which is the point where the plastic region begins.

For reference, the Ultimate Stress Point in FIG. 3 is the point where the stress that can be endured before the material is destroyed is the maximum, and the Breaking Point in FIG. 3 can be understood as the point at which the material is destroyed.

Although specific embodiments have been described in the detailed description of the present specification, various modifications are possible without departing from the scope of the present specification. Therefore, the scope of the present specification should not be limited to the above-described embodiments, but should be determined by the claims and equivalents of this invention as well as the later-described claims.

10: single layer
100: Infusion tube

Claims (11)

40 to 85% by weight of very low density polyethylene; and
10 to 50% by weight of polyethylene-based elastomer; and
A polyolefin-based environmentally friendly tube composition comprising 5 to 10% by weight of linear low-density polyethylene. According to claim 1,
The ultra-low density polyethylene is polymerized under a metallocene catalyst and is characterized in that it is a mixture of one or more ethylene-α-olefins selected from ethylene, propylene, 1-butene, 1-hexene, and 1-octene. A polyolefin-based eco-friendly tube composition. According to claim 1,
A polyolefin-based eco-friendly tube composition, characterized in that the melt index (g/10 min) of the ultra-low density polyethylene is 1 to 10 at 190°C and a load of 2.16 kg. According to claim 1,
The polyolefin-based elastomer has an ethylene content of 70 to 95% by weight, propylene, 1-butene, 1-pentene, 1-hexene, 1-heptene, 1-octene, 1-nonene, 1-decene, and 1-dodecene. A polyolefin-based eco-friendly tube composition, characterized in that it is a mixture of at least one selected from the group consisting of ethylene-α-olefin copolymer-based elastomers having a content of 5 to 30% by weight of at least one α-olefin selected from among. According to claim 1,
A polyolefin-based eco-friendly tube composition, characterized in that the melt index (g/10 min) of the polyethylene-based elastomer is 1 to 10 at 190°C and a load of 2.16 kg. According to claim 1,
The linear low-density polyethylene is one or more ethylene-α-olefins selected from propylene, 1-butene, 1-pentene, 1-hexene, 1-heptene, 1-octene, 1-nonene, 1-decene and 1-dodecene. A polyolefin-based eco-friendly tube composition comprising: According to claim 1,
A polyolefin-based eco-friendly tube composition, characterized in that the melt index (g/10 min) of the linear low-density polyethylene is 0.1 or more and 10 or less at 190°C and a load of 2.16 kg. According to claim 1,
A polyolefin-based eco-friendly tube composition, characterized in that the hardness of the polyolefin-based eco-friendly tube composition is 70 to 90 Shore A. According to claim 1,
A polyolefin-based eco-friendly tube composition, characterized in that the flexural modulus of the polyolefin-based eco-friendly tube composition is 200 MPa or less. According to claim 1,
A polyolefin-based eco-friendly tube composition, characterized in that the necking strain rate of the IV tube manufactured from the polyolefin-based eco-friendly tube composition is within 5%. The method of claims 1 to 10,
An eco-friendly IV fluid set, characterized in that the polyolefin-based eco-friendly tube composition is applied to at least one of a medical tube, a drip tube, and a drip container having one or more layers.

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