KR20240012671A - Implant scan body including a coating layer with reduced surface reflectance and increased biocompatibility - Google Patents

Abstract

The present invention relates to a scan body or abutment for implants that includes a coating layer that reduces surface reflectance and increases biocompatibility. By lowering the surface reflectance, it prevents light reflection when an optical scanner is used to scan a tooth model. As a result, highly accurate scan data about the shape of the patient's teeth can be secured, and since it has high biocompatibility, problems such as inflammation inside the oral cavity such as the gums do not occur.

Description

Implant scan body including a coating layer with reduced surface reflectance and increased biocompatibility}

The present invention relates to a scan body for implants including a coating layer that reduces surface reflectance and increases biocompatibility.

An implant is a biocompatible implant body (fixture) that has been enlarged to sufficiently cover the jawbone where there is a missing tooth or where a tooth was extracted through additional surgery such as bone grafting or bone lengthening. It is a dental treatment procedure that restores the function of natural teeth by implanting them.

The implant undergoes a process of bone remodeling of the jawbone around the implant after osseointegration, which is a morphological, physiological, and direct bond between the jawbone that maintains normal function and the surface of the implant body, is achieved. There are several types of such implants, but recently, screw-type intraosseous implants are mainly used.

The implant is largely composed of a fixture, an abutment, and a crown. The fixture is a part that serves as the root of the tooth and is mainly made of titanium, and the abutment is made of titanium and the crown. The part that connects the fixture corresponds to the neck of a natural tooth, and the crown is an upper prosthesis of an implant and corresponds to the head of a tooth in a natural tooth. Considering the position or condition of the tooth, it is made of gold or ceramic material. use

For implants, first, the location of the implant is confirmed and drilling is performed to create a hole in the jawbone for the implant body to fit into. In other words, after drilling several times until the size matches the diameter of the implant body, the implant body (fixture) is carefully placed. Once satisfactory osseointegration is achieved with the implanted fixture, the process of creating an artificial tooth prosthesis (crown) is performed by connecting an abutment.

Artificial tooth prosthesis takes an impression of the patient's teeth into which the fixture is implanted, creates a tooth model based on the impression, and then scans the tooth model to create a model of the prosthesis suitable for the shape of the patient's teeth based on the scan data obtained. It is produced through a process of creating .

However, this method has the problem of making the process complicated, such as having to make an impression and create a model based on that impression. Considering these problems, a method of scanning by directly inserting the abutment model into the patient's mouth can be considered.

At this time, in order to create a model of a prosthesis suitable for the shape of the patient's teeth, the scan data obtained by scanning the tooth model must include accurate fixture scan data (center coordinates and direction information of the screw hole of the fixture).

However, when the scan data of a tooth model is acquired using an optical scanner, there is an advantage in that scan data can be acquired in a relatively short period of time. However, the scan data of the tooth model acquired using an optical scanner does not require an accurate fixture. There is a problem that scan data is not included.

In addition, since the entire scan area is not exposed because it is covered by the gums after being coupled to the fixture implanted inside the patient's gums, there is a problem in that it is difficult to obtain scan data of an abutment model that matches the shape of the patient's teeth.

There are two types of scanning methods, one using a laser and the other using photography. The laser method is sensitive to light reflection, so the scan body of the conventional abutment model made of metal was not scanned accurately.

Accordingly, a method of reducing light reflection by spraying the abutment model may be considered, but there is a problem in that a large data error may occur depending on the method of spraying.

As described above, it is possible to secure high-accuracy scan data about the shape of the patient's teeth by preventing reflection of light on the abutment model, and by increasing biocompatibility, the coating composition does not cause side effects in the body even when a coating layer is formed on the abutment model. Development is needed.

(Patent Document 1) KR 10-1461105 B1

The purpose of the present invention is to provide a scan body for implants including a coating layer that reduces surface reflectance and increases biocompatibility.

Another object of the present invention is to lower the surface reflectance, prevent light reflection when using an optical scanner to scan a tooth model, secure scan data with high accuracy about the shape of the patient's teeth, and have high biocompatibility. , to provide a scan body for implants that does not cause problems such as inflammation inside the oral cavity, such as the gums.

Another object of the present invention is to provide an abutment for implants including a coating layer that reduces surface reflectance and increases biocompatibility.

In order to achieve the above object, the present invention provides a scan body for implants including a coating layer that reduces surface reflectance and increases biocompatibility, and includes: a scan body for implants made of a metal material; And a coating layer formed on the surface of the scan body, wherein the coating layer includes a hyaluronic acid (HA) coating layer, a poly(allylamine hydrochloride) (PAH) coating layer, and a coating layer represented by the following formula (1) It may include a CYD coating layer comprising a compound that:

[Formula 1]

[Formula 2]

[Formula 3]

here,

* refers to the part that is combined,

n, m and o are the same or different from each other and are each independently an integer from 1 to 100,

L ₁ to L ₈ are the same or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms,

_{X 1} to

The coating layer includes a first coating layer containing a compound selected from the group consisting of a hyaluronic acid (HA) coating layer, a poly(allylamine hydrochloride) (PAH) coating layer, and a mixture thereof; And it may include a CYD coating layer formed on the surface of the first coating layer.

The first coating layer may be formed by repeatedly forming a hyaluronic acid coating layer and a poly(arylamine hydrochloride) coating layer.

The CYD coating layer may be a cationic polymer (Cat-CyD) containing the compound represented by Formula 1.

The metal material may be zirconia material, titanium material, chrome material, cobalt material, platinum, gold, or an alloy material thereof.

An abutment for an implant according to another embodiment of the present invention includes an abutment for an implant made of a metal material; And a coating layer formed on the surface of the abutment, wherein the coating layer includes a hyaluronic acid (HA) coating layer, a poly(allylamine hydrochloride) (PAH) coating layer, and the following formula (1): A CYD coating layer comprising a compound indicated by:

[Formula 1]

[Formula 2]

[Formula 3]

here,

* refers to the part that is combined,

n, m and o are the same or different from each other and are each independently an integer from 1 to 100,

L ₁ to L ₈ are the same or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms,

_{X 1} to

The present invention relates to a scan body or abutment with a coating layer, which lowers the surface reflectance and prevents light reflection when using an optical scanner to scan a tooth model, thereby providing highly accurate scan data about the shape of the patient's teeth. It can be secured and has high biocompatibility, so problems such as inflammation inside the oral cavity such as gums do not occur.

Figure 1 shows the results of measuring reflectance on a titanium surface with a coating layer formed according to an embodiment of the present invention.
Figure 2 shows the results of MTT analysis according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement it. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein.

The implant of the present invention refers to a medical device for implantation in a living body that performs its intended function by being implanted in the living body, and the dental implant is installed in or on the jaw bone (gum and This means that it includes all fixtures implanted between the gum bones.

The implant generally consists of a fixture, an abutment, and a crown. The implant of the present invention refers to a concept including a fixture, abutment, and crown.

An abutment for an implant according to an embodiment of the present invention is an implant abutment for connecting a crown and a fixture. The abutment is made of a metal material, and the abutment made of the metal material emits light when scanning. A coating layer that prevents reflection and has excellent biocompatibility can be formed.

Let's briefly look at the implant procedure process.

First, use a drill to drill the location of the fixture. Afterwards, a fixture is installed in the perforated area into the alveolar bone and osseointegrated, allowing it to become an artificial tooth root.

After a certain period of time has passed and the osseointegration of the fixture is complete, an abutment is inserted into the fixture and fastened with an abutment screw so that the fixture and abutment become one body.

Then, the implant procedure can be completed by attaching a crown of the same shape as a natural tooth, that is, an artificial tooth prosthesis, to the abutment as the final prosthesis.

If it is necessary to shape the gums so that they can heal well before placing an artificial tooth prosthesis, a healing abutment can be attached to the fixture in advance. At this time, the healing abutment can be used temporarily until an artificial tooth is placed.

In order to acquire a 3D shape using a digital intraoral scanner and manufacture prosthetics based on it, a 3D image of the inside of the oral cavity is acquired using a digital intraoral scanner. At this time, scan is performed after fixing the scan body to the fixture. In this way, when performing a scan to acquire a 3D image of the inside of the oral cavity, using a separate scan body allows the user to accurately determine the exact location and direction of the hexagonal groove formed inside the fixture, thereby This is to accurately design abutments and crowns.

In other words, a separate member called a scan body is used to recognize the thickness of the gums, which vary depending on the patient, the resulting implantation depth, and the correct direction.

A scan body can be used as a method to acquire images of the inside of the oral cavity, and a scan abutment can also be used.

These artificial tooth prosthesis take an impression of the patient's teeth, create a model in a dental laboratory based on the impression, and then combine the model with an implant scan abutment, which is an abutment model. After scanning, the CAD data of the implant scan abutment is matched to the scan data on a CAD program to create a prosthesis model suitable for the shape of the patient's teeth.

However, the scan body and abutment are generally made of metal, and metal material reflects light, making it difficult to accurately scan the shape of the patient's teeth.

In general, metal materials used in the manufacture of scan bodies and abutments may be zirconia, titanium, chrome, cobalt, platinum, gold, or alloys thereof, preferably titanium, but are not limited to the above examples. No.

To solve the above problem, a method of preventing light reflection by forming a coating layer on the surface of a metal material can be used. A compound is typically used to form the coating layer, but as will be described later, there is a risk of inflammation caused by the coating layer and a problem of poor bonding with titanium may occur.

In other words, a problem may occur where the coating layer is not formed uniformly on the surface of titanium or the coating layer easily falls off.

Due to the above problems, when it is not easy to form a titanium coating layer, the effect of preventing light reflection by the coating layer is relatively low.

In order to prevent the above problems, the present invention is characterized by forming a coating layer on the surface of the metal material. In particular, it has excellent bonding strength to titanium and reduces light reflection, making it possible to obtain accurate oral images using an oral scanner. do.

Specifically, the coating layer may include a hyaluronic acid (HA) coating layer, a poly(allylamine hydrochloride) (PAH) coating layer, and a CYD coating layer containing a compound represented by the following formula (1): there is:

[Formula 1]

[Formula 2]

[Formula 3]

here,

* refers to the part that is combined,

n, m and o are the same or different from each other and are each independently an integer from 1 to 100,

L ₁ to L ₈ are the same or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms,

_{X 1} to

The hyaluronic acid polymer (HA) is a compound represented by the following formula (4):

[Formula 4]

here,

p is an integer from 1 to 100.

The poly(arylamine hydrochloride) (PAH) is a compound represented by the following formula (5):

[Formula 5]

here,

q is an integer from 1 to 100.

Specifically, the coating layer formed on the surface of the scan body or abutment is from the group consisting of a hyaluronic acid (HA) coating layer, a poly(allylamine hydrochloride) (PAH) coating layer, and a mixture thereof. A first coating layer comprising a selected compound; And it may include a CYD coating layer formed on the surface of the first coating layer.

PAH forming the first coating layer may be a cationic polymer compound, and HA may be an anionic polymer compound.

The compound represented by Formula 1 is a cationic polymer compound (Cat-CyD) when the quaternary ammonium salt represented by Formula 2 is combined, and when the compound represented by Formula 3 is combined, it is an anionic polymer compound (Ani) -CyD).

The first coating layer may include a bilayer as one repeating unit, and the bilayer may include the cationic polymer compound and the anionic polymer compound described above as one set.

The first coating layer may be a plurality of layers of [PAH/HA]. [PAH/HA] means that poly(arylamine hydrochloride) and hyaluronic acid polymer are repeatedly laminated as one layer.

The first coating layer may be formed, and a CYD coating layer may be formed on the surface of the first coating layer.

In addition, the method of forming a coating layer according to another embodiment of the present invention is to form a first coating layer by alternately laminating hyaluronic acid polymer (HA) and poly(allylamine hydrochloride) (PAH). forming a; And it may include forming a CYD coating layer by laminating a polymer represented by the following formula (1):

[Formula 1]

[Formula 2]

[Formula 3]

here,

* refers to the part that is combined,

n, m and o are the same or different from each other and are each independently an integer from 1 to 100,

L ₁ to L ₈ are the same or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms,

_{X 1} to

The CYD coating layer may be a cationic polymer (Cat-CyD) where the compound represented by Formula 1 includes the compound represented by Formula 2.

Manufacturing Example 1

Preparation of cationic Cat-CyD polymers

In a 50ml round flask, dissolve 1g (0.025mol) of NaOH in 20ml Di-water to prepare a 0.022mol% (0.048wt%) NaOH aqueous solution, then add 1.135g (0.001mol) of β-CyD and incubate at 25°C for 18 hours. It was dissolved by stirring. After stirring was completed, the round flask containing the reactants was moved to an oil bath and the hot plate temperature was set to 60°C. When the set temperature is reached, 1.388g (1.2ml, 0.015mol) of Epichlorohydrin (EP) is added at a rate of about 0.1ml/min, and then 0.2792g (0.002mol) of Choline chloride (CC) is quickly added to the reactor and the joint is stirred. It was closed with copper (stopper). While polymerization was in progress, the inside of the reactor was maintained at 60°C, and the reaction was allowed to proceed for 24 hours in this state. Then, the pH of the reactant was adjusted to neutral using a 12N HCl aqueous solution to complete the polymerization. To purify the obtained solution, dialysis was performed for 48 hours using MWCO 1000 and 3500 membranes depending on the purpose. The solution obtained in this way was prepared in pure powder form through a freeze-drying process.

Yield: 0.74 g (22.2%)

Production example 2

Formation of a coating layer on the titanium surface

Hyaluronic acid polymer (HA) and poly(allylamine hydrochloride) (PAH) were purchased and used. Cat-CyD polymer was synthesized in the same manner as Preparation Example 1.

Each polymer electrolyte was adjusted to a concentration of 0.01M using double distilled water, and the pH was maintained at 3.0 or 4.5. The washed and dried titanium substrate was immersed in a polymer electrolyte solution and polymer was deposited on the surface.

Specifically, the titanium substrate was first soaked in a cationic PAH solution for 15 minutes to induce adsorption of PAH, and then washed twice using double distilled water to remove residual PAH. [PAH/HA] coating film was formed by alternately introducing anionic HA with PAH in the same manner as introducing PAH. The number of times the immersion was repeated, the layers were laminated to the desired thickness. Afterwards, it was immersed in a cationic Cat-β-CyD solution to form a coating layer.

Experimental Example 1

Reflectance measurement results

A coating layer was formed on a titanium substrate as in the above production example, and the degree of decrease in reflectance was evaluated through experiment.

As a comparative example, titanium without a coating layer (Bare(Ti foil), titanium with a coating layer of [CYD/HA] ₆ formed, and titanium with a coating layer of [CYD/HA] _6.5 were evaluated together.

The experimental results are shown in Figure 1.

In Preparation Example 2, it was confirmed that the reflectance of titanium with a coating layer was reduced by more than 50% compared to titanium without a coating layer, confirming that the effect of preventing light reflection was excellent.

Experimental Example 2

Biotoxicity evaluation

To analyze cell viability, Trypan blue cell counting and MTT-assay were selected and analyzed appropriately for each substrate.

Cell count was performed by removing cells grown on each substrate for a certain period of time from the substrate using Trypsin-EDTA, distinguishing dead cells from live cells using Trypan blue, counting the cells with a hemocytometer, and calculating them using the formula below. .

For the MTT-assay, thiazolyl blue tetrazolium bromide (MTT; ab146345, abcam) was treated at 5 mg/ml per well, cultured in an incubator at 37°C and CO ₂ 5% for 2 hours, and then dissolved using dimethyl sulfoxide (DMSO). Then, the absorbance was measured at 570 nm.

The experimental results are shown in Figure 2. Compared to the survival rate when cells were cultured on an uncoated titanium (Ti) surface, the survival rate for samples coated with (PAH/HA) _7- CYD increased by more than 160%. Through the above experiment, compared to using a general titanium material as a scan body or abutment, when using a scan body or abutment with a coating layer of the present invention, the light reflectance is lowered and the product is non-cytotoxic. It can be used as

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concept of the present invention defined in the following claims are also possible. falls within the scope of rights.

Claims (6)

Scan body for implant made of metal; and
It includes a coating layer formed on the surface of the scan body,
The coating layer includes a hyaluronic acid (HA) coating layer, a poly(allylamine hydrochloride) (PAH) coating layer, and a CYD coating layer containing a compound represented by the following formula (1)
Scan body for implants containing a coating layer that reduces surface reflectance and increases biocompatibility:
[Formula 1]

[Formula 2]

[Formula 3]

here,
* refers to the part that is combined,
n, m and o are the same or different from each other and are each independently an integer from 1 to 100,
L ₁ to L ₈ are the same or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms,
_{X 1} to According to paragraph 1,
The coating layer includes a first coating layer containing a compound selected from the group consisting of a hyaluronic acid (HA) coating layer, a poly(allylamine hydrochloride) (PAH) coating layer, and a mixture thereof; and
Comprising a CYD coating layer formed on the surface of the first coating layer
A scan body for implants containing a coating layer that reduces surface reflectance and increases biocompatibility. According to paragraph 2,
The first coating layer is formed by repeatedly forming a hyaluronic acid coating layer and a poly(arylamine hydrochloride) coating layer.
A scan body for implants containing a coating layer that reduces surface reflectance and increases biocompatibility. According to paragraph 2,
The CYD coating layer is a cationic polymer (Cat-CyD) containing the compound represented by Formula 1.
A scan body for implants containing a coating layer that reduces surface reflectance and increases biocompatibility. According to paragraph 1,
The metal material is zirconia material, titanium material, chrome material, cobalt material, platinum, gold, or an alloy material thereof.
A scan body for implants containing a coating layer that reduces surface reflectance and increases biocompatibility. Abutment for implant made of metal; and
It includes a coating layer formed on the surface of the abutment,
The coating layer includes a hyaluronic acid (HA) coating layer, a poly(allylamine hydrochloride) (PAH) coating layer, and a CYD coating layer containing a compound represented by the following formula (1)
Abutment for implants containing a coating layer that reduces surface reflectance and increases biocompatibility:
[Formula 1]

[Formula 2]

[Formula 3]

here,
* refers to the part that is combined,
n, m and o are the same or different from each other and are each independently an integer from 1 to 100,
L ₁ to L ₈ are the same or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms,
_{X 1} to