KR20240012360A - 고콜레스테롤혈증을 치료하기 위한 조성물 및 방법 - Google Patents
고콜레스테롤혈증을 치료하기 위한 조성물 및 방법 Download PDFInfo
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Abstract
본 개시는 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 그의 조성물, 방법, 및 용도를 제공한다. 구체적으로, 본 개시는 세포에서 LDLR(Low-Density Lipoprotein Receptor) 유전자의 내인성 발현을 증가시키는 방법으로서, 상기 방법은 상기 LDLR 유전자 또는 상기 LDLR 유전자에 의해 코딩되는 전사체를 변형시키는 단계, 하나 이상의 뉴클레아제, 및 가이드 서열 부분을 포함하는 RNA 분자를 포함하는 조성물을 상기 세포에 도입하는 단계를 포함하고, 상기 RNA 분자의 가이드 서열 부분은 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함하는 것인 방법을 제공한다.
Description
본 출원은 2022년 1월 28일에 출원된 미국 가출원 번호 63/304,170 및 2021년 3월 22일에 출원된 미국 가출원 번호 63/164,396의 이익을 주장하고, 각 출원의 내용은 참조에 의해 본원에 포함된다.
본 출원 전체에서, 괄호 안의 참조를 포함하여 다양한 간행물이 참조된다. 본 출원에서 언급된 모든 간행물의 개시 전체는 본 발명이 속하는 기술 및 본 발명과 함께 사용될 수 있는 기술의 특징에 대한 추가적인 설명을 제공하기 위해 본 출원에 참조에 의해 포함된다.
서열 목록에 대한 참조
본 출원은 본 출원의 일부로 2021년 3월 21일에 제출된 텍스트 파일에 포함된, MS-Windows와 운영 체제 호환성을 갖는 IBM-PC 머신 포맷으로 2022년 3월 17일에 생성되고 크기가 2,288 킬로바이트인 "220321_91709-A-PCT_Sequence_Listing_AWG.txt"로 명명된 파일에 존재하는 뉴클레오티드 서열을 참조에 의해 포함한다.
고콜레스테롤혈증, 또는 고 콜레스테롤은 높은 혈장 콜레스테롤 수준의 존재로 정의된다. 가족성 고콜레스테롤혈증(Familiar hyperchloesterolemia: FH)은 주로 저밀도 지질단백질 수용체(Low-Density Lipoprotein Receptor: LDLR)의 돌연변이로 인해 콜레스테롤이 증가하고 심혈관 질환이 조기에 발병하는 유전성 질환이다.
저밀도 지질단백질 수용체(LDLR)는 혈장의 주요 콜레스테롤-운반 지질단백질인 저밀도 지질단백질(LDL)과 결합하여 엔도사이토시스(endocytosis)를 통해 이를 세포 내로 운반한다. 내부화되기 위해서, 수용체-리간드 복합체가 먼저 클라트린-코팅된 피트(clathrin-coated pit) 내로 모여야 한다. LDL 콜레스테롤의 상승된 수준은 관상동맥 심장병의 발병에 중심적인 역할을 한다. LDL 수용체 또는 그의 조절의 결함은 가족성 고콜레스테롤혈증을 유발하는 LDLR 유전자의 고-영향 기능 상실(high impact loss-of function) 돌연변이에 의해 입증된 바와 같이, 높은 수준의 LDL 및 조기 심혈관 질환을 초래한다.
스타틴이나 에제티미브(Ezetimibe)와 같은 평생 지질-저하 약물이 현재 이용가능하나. 이들은 종종 일부 환자에 의해 불내성이고, 원하는 LDL-C 수준에 도달하지 못한다. 보다 최근의 치료 접근법은 LDLR 리소좀 분해를 촉진하는 단백질인 PCSK9(Proprotein Covertase Subtilisin/Kexin type 9)를 일시적으로 억제하는 피하 주사 단일클론 항체에 기반한다. 염기 편집(base editing)에 의한 PCSK9의 영구적 억제가 현재 개발되고 있으나, FH의 발병 근거도 아닌 유전자의 비가역적 넉다운의 장기적인 결과는 아직 알려지지 않았다.
발명의 요약
고콜레스테롤 또는 고콜레스테롤혈증(예를 들어, 가족성 고콜레스테롤혈증)을 치료 또는 예방하기 위해 내인성 LDLR 유전자의 발현 또는 그의 전사체의 반감기를 증가시키기 위한 접근법이 개시된다. 본 발명의 일부 양태에 따르면, 개시된 접근법은 고콜레스테롤 또는 고콜레스테롤혈증(예를 들어, 가족성 고콜레스테롤혈증)을 치료 또는 예방하기 위해 LDLR 유전자의 3' 비번역 영역(UTR)을 표적화하기 위한 것이다. 범위를 임의의 작용 메커니즘으로 한정하지 않으면서, 본 발명의 일부 양태에 따르면, 개시된 접근법은 LDLR 유전자의 발현을 강화하고 저밀도 지질단백질 콜레스테롤(LDL-C) 흡수를 촉진하기 위해, LDLR 전사 및/또는 번역의 제한을 담당하는 3' 비번역 영역(UTR)의 영역을 녹아웃, 제거, 절단 또는 차단하기 위한 것이다. 따라서, LDLR 분자의 반감기 또는 발현 수준을 증가시키고, 그에 의해 고콜레스테롤혈증을 치료, 억제, 예방 및/또는 개선하기 위해, 바람직하게는 간세포, 예를 들어 헤파토사이트(hepatocyte)에서 본원에 기술된 바와 같이, LDLR 유전자의 3' UTR 중 조절 요소 결합 부위(예를 들어, miRNA 결합 부위)의 이중 대립유전자 절제 또는 녹아웃이 이용될 수 있다. 일부 구체예에서, 본원에 기재된 바와 같이, LDLR 유전자의 3' UTR의 적어도 부분적 절제(excision)는 LDLR 분자의 전사체 또는 발현의 반감기를 증가시키고, 그에 의해 고콜레스테롤혈증을 치료, 억제, 예방 및/또는 개선하기 위해 이용될 수 있다.
일부 구체예에서, 세포에서 내인성 LDLR (Low-Density Lipoprotein Receptor) 유전자의 발현을 증가시키는 방법으로서, 상기 방법은 LDLR 유전자 또는 LDLR 유전자에 의해 코딩된 전사체를 변형시키는 단계를 포함하는 것인 방법이 제공된다. 일부 구체예에서, 세포에서 내인성 저밀도 지질단백질 수용체(LDLR) 유전자의 발현을 증가시키는 방법으로서, 상기 방법은 상기 LDLR 유전자의 3' UTR 또는 LDLR 전사체의 적어도 일부를 변형, 차단 또는 제거하는 단계를 포함하는 것인 방법이 제공된다.
일 구체예에서, 상기 방법은:
CRISPR 뉴클레아제 또는 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 분자; 및
17-50개의 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 또는 그를 코딩하는 뉴클레오티드 분자를 포함하는 조성물을 세포에 도입하는 단계를 포함하고,
상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체는 상기 LDLR 유전자의 대립유전자의 이중가닥 절단을 생성(affect)한다.
일부 구체예에서, 상기 LDLR 3'UTR 또는 그의 일부는 CRISPR 뉴클레아제와 제1 RNA 분자에 의해 생성된 제1 이중가닥 절단과 CRISPR 뉴클레아제와 제2 RNA 분자에 의해 형성된 제2 이중가닥 절단의 조합에 의해 절제된다.
비-한정적인 예로서, 상기 LDLR 3'UTR의 일부는 OMNI-50 CRISPR 뉴클레아제(서열번호 10749) 및 서열번호 7707을 포함하는 가이드 서열 부분을 포함하는 제1 RNA 분자를 포함하는 제1 CRISPR 복합체와 OMNI-50 CRISPR 뉴클레아제(서열번호 10749) 및 서열번호 9843을 포함하는 가이드 서열 부분을 포함하는 제2 RNA 분자를 포함하는 제2 CRISPR 복합체의 조합된 활성에 의해 절제될 수 있다.
또 다른 비-한정적인 예에서, 상기 LDLR 3'UTR의 일부는 OMNI-79 CRISPR 뉴클레아제(서열번호 10744) 및 서열번호 7871을 포함하는 가이드 서열 부분을 포함하는 제1 RNA 분자를 포함하는 제1 CRISPR 복합체와 OMNI-79 CRISPR 뉴클레아제(서열번호 10744) 및 서열번호 9843을 포함하는 가이드 서열 부분을 포함하는 제2 RNA 분자를 포함하는 제2 CRISPR 복합체의 조합된 활성에 의해 절제될 수 있다.
본 발명의 구체예에 따르면, 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자가 제공된다.
본 발명의 일부 구체예에 따르면, 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물이 제공된다.
본 발명의 일부 구체예에 따르면, 세포에서 LDLR 유전자의 발현을 증가시키는 방법, 예를 들어, 세포에서 LDLR miRNA 결합 부위를 불활성화함으로써 LDLR 유전자의 발현을 증가시키는 방법으로서, 상기 방법은 상기 세포에 서열번호 1-10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 전달하는 단계를 포함하는 것인 방법이 제공된다. 일부 구체예에서, 상기 세포는 간 세포이다. 일부 구체예에서, 상기 세포는 헤파토사이트(hepatocyte)이다. 일부 구체예에서, 상기 세포는 줄기 세포이다. 일부 구체예에서, 상기 세포로의 전달은 생체내, 생체외 또는 시험관내에서 수행된다. 일부 구체예에서, 상기 세포로의 전달은 렌티바이러스, 아데노-연관 바이러스(AAV) 또는 나노입자를 간에 생체내 전달함으로써 수행된다. 일부 구체예에서, 상기 방법은 생체외에서 수행되고, 상기 세포는 개별 환자로부터 제공/적출(explant)된다. 일부 구체예에서, 상기 방법은 결과적으로 수득된, 불활성화된 miRNA 결합 부위를 포함하는 적어도 하나의 변형된 LDLR 대립유전자를 갖는 세포를 개별 환자에게 도입하는 단계를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 고콜레스테롤혈증(예를 들어, 가족성 고콜레스테롤혈증)을 치료 및/또는 예방하는 방법이 제공되며, 상기 방법은 고콜레스테롤혈증을 갖거나 경험할 위험이 있는 개체의 세포에 서열번호 1-10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 전달하는 단계를 포함한다.
본 발명의 일부 구체예에 따르면, 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 세포에게 전달하는 것을 포함하는, 세포에서 LDLR 대립유전자의 miRNA 결합 부위를 불활성화하기 위한, 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물의 용도가 제공된다.
본 발명의 구체예에 따르면, 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 포함하는 약제로서, 상기 약제는 세포에게 상기 조성물을 전달하는 것에 의해 투여되는 것인 약제가 제공된다.
본 발명의 일부 구체예에 따르면, 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물의 고콜레스테롤혈증을 치료, 개선 또는 예방하기 위한 용도로서, 고콜레스테롤혈증을 갖거나, 경험할 위험이 있는 개체의 세포에 상기 조성물을 전달하는 것을 포함하는 것인 용도가 제공된다.
본 발명의 일부 구체예에 따르면, 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 포함하는, 고콜레스테롤혈증을 치료, 개선 또는 예방하는데 사용하기 위한 약제로서, 상기 약제는 고콜레스테롤혈증을 갖거나 경험할 위험이 있는 개체의 세포에 상기 조성물을 전달하는 것에 의해 투여되는 것인 약제가 제공된다.
본 발명의 일부 구체예에 따르면, 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자, CRISPR 뉴클레아제, 및 선택적으로 tracreRNA 분자, 및 세포에 상기 RNA 분자, CRISPR 뉴클레아제, 및 선택적으로, tracrRNA를 전달하기 위한 설명서를 포함하는, 세포에서 LDLR 발현을 증가시키기 위한 키트가 제공된다.
본 발명의 일부 구체예에 따르면, 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자, CRISPR 뉴클레아제, 및/또는 tracreRNA 분자, 및 고콜레스테롤혈증을 갖거나 고콜레스테롤혈증의 위험이 있는 개체의 세포에 상기 RNA 분자, CRISPR 뉴클레아제, 및 선택적으로 tracrRNA를 전달하기 위한 설명서를 포함하는, 개체에서 고콜레스테롤혈증을 치료 또는 예방하기 위한 키트가 제공된다.
본 발명의 일부 구체예에 따르면, 본원에 기술된 방법 중 어느 하나에 따라 변형되거나, 본원에 기술된 조성물 중 어느 하나를 사용하여 변형된 세포가 제공된다.
다르게 정의되지 않는 한, 본 명세서에 사용된 모든 기술 및/또는 과학 용어는 본 발명이 속하는 기술분야의 통상의 기술자가 일반적으로 이해하는 것과 동일한 의미를 갖는다. 본 명세서에 기술된 것과 유사하거나 균등한 방법 및 재료가 본 발명의 구체예의 실시 또는 테스트에 사용될 수 있지만, 예시적인 방법 및/또는 재료가 하기에 기술된다. 상충되는 경우, 정의를 포함한 본 명세서가 우선할 것이다. 또한, 재료, 방법 및 실시예는 단지 설명하는 것이며, 반드시 한정하는 것으로 의도되지 않는다.
본원에서 앞서 및 다른 곳에 사용되는 바와 같이 용어 "하나("a" 및 "an")"는 열거된 구성요소 중 "하나 이상"을 지칭하는 것으로 이해되어야 한다. 구체적으로 달리 언급되지 않는 한, 단수의 사용은 복수를 포함한다는 것이 통상의 기술자에게 명백할 것이다. 따라서, 용어 "하나" 및 "적어도 하나"는 본 출원에서 호환 적으로 사용된다.
달리 표시되지 않는 한, 본 교시를 더 잘 이해하기 위해 및 교시의 범위를 한정하지 않는 방식으로, 양, 백분율 또는 비율을 표현하는 모든 숫자, 및 본 명세서 및 청구범위에서 사용되는 기타 수치는 모든 경우에 용어 "약"으로 수식되는 것으로 이해되어야 한다. 따라서, 반대로 표시되지 않는 한, 하기 명세서 및 첨부된 청구범위에 제시된 수치 파라미터는 얻고자 하는 원하는 특성에 따라 변할 수 있는 근사치이다. 적어도, 각각의 수치 파라미터는 적어도 보고된 유효 숫자의 수에 비추어 및 반올림 기법을 적용하여 해석되어야 한다.
본 논의에서 달리 언급되지 않는 한, 본 발명의 구체예의 특징 또는 특징들의 특징적인 조건 또는 관계를 수식하는 "실질적으로" 및 "약"과 같은 형용사는 조건 또는 특징이 의도된 적용에 대한 구체예의 작동에 허용 가능한 허용 오차(tolerance) 내에서 정의됨을 의미하는 것으로 이해된다. 달리 나타내지 않는 한, 명세서 및 청구범위에서 단어 "또는"은 배타적인 "또는"이 아닌 포괄적인 "또는"인 것으로 간주되며, 그것이 결합시키는 항목들 중 적어도 하나 또는 임의의 조합을 나타낸다.
본 출원의 설명 및 청구범위에서, 동사 "포함하다(comprise)", "함유하다(include)" 및 "갖다" 각각 및 이들의 활용어는 동사의 목적어 또는 목적어들이 반드시 동사의 주어 또는 주어들의 구성요소, 요소 또는 부분의 완전한 열거가 아니라는 것을 나타내는 데 사용된다. 본원에서 사용되는 다른 용어는 당업계에 잘 알려진 의미로 정의되는 것으로 의도된다.
본 발명의 일부 구체예에서, DNA 뉴클레아제는 표적 부위에서 DNA 절단(break)을 생성(affect)하여, 세포 복구 메커니즘, 예를 들어 비상동 말단 연결(non-homologous end-joining: NHEJ)이나, 이에 한정되지 않는 세포 복구 메커니즘을 유도하기 위해 이용된다. 고전적인 NHEJ 동안, 이중가닥 절단(double-strand break: DSB) 부위의 양 말단이 신속하나, 부정확한 방식으로(즉, 작은 삽입이나 결실의 형태로 절단 부위에서 DNA의 돌연변이가 빈번하게 초래됨) 함께 라이게이션된다.
본원에서 사용된, 용어 "변형된 세포(modified cell)"는 표적 서열과의 혼성화, 즉 온타겟(on-target) 혼성화의 결과로 RNA 분자와 CRISPR 뉴클레아제의 복합체에 의해 이중가닥 절단이 수행된 세포를 의미한다.
본원에서 사용된, 용어 "표적화 서열(targeting sequence)" 또는 "표적화 분자"는 특정 표적 서열에 혼성화할 수 있는 뉴클레오티드 서열을 포함하는 뉴클레오티드 서열 또는 분자를 의미하고, 예를 들어, 표적화 서열은 표적화 서열의 길이에 따라 표적화되는 서열에 적어도 부분적으로 상보적인 뉴클레오티드 서열을 갖는다. 표적화 서열 또는 표적화 분자는 단독으로 또는 다른 RNA 분자와 함께 CRISPR 뉴클레아제와 복합체를 형성할 수 있는 RNA 분자의 일부일 수 있으며, 상기 표적화 서열은 CRISPR 복합체의 표적화 부분(targeting portion)으로 작용한다. 표적화 서열을 갖는 분자가 CRISPR 분자와 동시에 존재하는 경우, 상기 RNA 분자는 단독으로 또는 추가적인 하나 이상의 RNA 분자(예: tracrRNA 분자)와 조합하여 CRISPR 뉴클레아제를 특정 표적 서열로 표적화할 수 있다. 비한정적인 예로서, CRISPR RNA 분자, 또는 단일 가이드 RNA 분자의 가이드 서열 부분은 표적화 분자로 작용할 수 있다. 각 가능성은 별개의 구체예를 나타낸다. 표적화 서열은 원하는 서열을 표적화하도록 맞춤 설계될 수 있다.
본원에서 사용된, 용어 "표적(target)"은 표적화된 뉴클레오티드 서열을 갖는 핵산에 대한 표적화 분자의 표적화 서열의 우선적인 혼성화를 의미한다. 용어 "표적"은 가변 혼성화 효율(variable hybridization efficiency)을 포함하여, 표적화된 뉴클레오티드 서열을 갖는 핵산의 우선적인 표적화가 존재하나, 온타겟 혼성화 외에, 의도하지 않은 오프타겟 혼성화가 또한 일어날 수 있는 것으로 이해된다. RNA 분자가 서열을 표적화하는 경우, RNA 분자와 CRISPR 뉴클레아제 분자의 복합체는 뉴클레아제 활성을 위해 상기 서열을 표적화하는 것으로 이해된다.
RNA 분자의 "가이드 서열 부분(guide sequence portion)"은 특정 표적 DNA 서열에 혼성화할 수 있는 뉴클레오티드 서열을 지칭하고, 예를 들어 가이드 서열 부분은 가이드 서열 부분의 길이를 따라 표적화되는 DNA 서열에 부분적으로 또는 완전히 상보적인 뉴클레오티드 서열을 갖는다. 일부 구체예에서, 상기 가이드 서열 부분은 길이가 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 또는 50개 뉴클레오티드, 또는 대략 17 내지 50, 17 내지 49, 17 내지 48, 17 내지 47, 17 내지 46, 17 내지 45, 17 내지 44, 17 내지 43, 17 내지 42, 17 내지 41, 17 내지 40, 17 내지 39, 17 내지 38, 17 내지 37, 17 내지 36, 17 내지 35, 17 내지 34, 17 내지 33, 17 내지 31, 17 내지 30, 17 내지 29, 17 내지 28, 17 내지 27, 17 내지 26, 17 내지 25, 17 내지 24, 17 내지 22, 17 내지 21, 18 내지 25, 18 내지 24, 18 내지 23, 18 내지 22, 18 내지 21, 19 내지 25, 19 내지 24, 19 내지 23, 19 내지 22, 19 내지 21, 19 내지 20, 20 내지 22, 18 내지 20, 20 내지 21, 21 내지 22, 또는 17 내지 20개 뉴클레오티드이다. 일부 구체예에서, 상기 가이드 서열 부분은 17 내지 50개 뉴클레오티드이다. 일부 구체예에서, 상기 가이드 서열 부분은 17 내지 25개 뉴클레오티드이다. 일부 구체예에서, 상기 가이드 서열 부분은 17 내지 22개 뉴클레오티드이다. 일부 구체예에서, 상기 가이드 서열 부분은 17 내지 20개 뉴클레오티드이다. 일부 구체예에서, 가이드 서열 부분의 전체 길이는 가이드 서열 부분의 길이를 따라 표적화된 DNA 서열에 완전히 상보적이다. 가이드 서열 부분은 CRISPR 뉴클레아제와 복합체를 형성할 수 있는 RNA 분자의 일부일 수 있으며, 상기 가이드 서열 부분은 CRISPR 복합체의 DNA 표적화 부분의 역할을 한다. 가이드 서열 부분을 갖는 DNA 분자가 CRISPR 분자와 동시에 존재할 때, 상기 RNA 분자는 CRISPR 뉴클레아제를 특정 표적 DNA 서열에 표적화할 수 있다. 각각의 가능성은 별개의 구체예를 나타낸다. RNA 분자는 원하는 서열을 표적화하도록 맞춤 설계될 수 있다. 따라서, "가이드 서열 부분"을 포함하는 분자는 표적화 분자의 한 유형이다. 일부 구체예에서, 가이드 서열 부분은 본원에 기재된 가이드 서열 부분, 예를 들어 서열번호 1-20246 중 어느 하나에 기재된 가이드 서열과 동일하거나 1, 2, 3, 4 또는 5개 이하의 뉴클레오티드가 다른 서열을 포함한다. 각 가능성은 별개의 구체예를 나타낸다. 이러한 구체예 중 일부에서, 가이드 서열 부분은 표적 서열에 완전히 상보적이고, 서열번호 1-20246 중 어느 하나에 기재된 서열과 동일한 서열을 포함한다. 본 출원 전체에 걸쳐, 용어 "가이드 분자", "RNA 가이드 분자", "가이드 RNA 분자", 및 "gRNA 분자"는 가이드 서열 부분을 포함하는 분자와 동의어이다.
본원에서 사용된 용어 "비차별적(non-discriminatory)"은 유전자의 모든 대립유전자에 공통적인 특정 DNA 서열을 표적으로 하는 RNA 분자의 가이드 서열 부분을 의미한다.
본 발명의 구체예에서, RNA 분자는 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함한다.
RNA 분자 및/또는 RNA 분자의 가이드 서열 부분은 변형된 뉴클레오티드를 포함할 수 있다. 뉴클레오티드/폴리뉴클레오티드에 대한 예시적인 변형은 합성일 수 있으며 천연 아데닌, 시토신, 티민, 우라실 또는 구아닌 염기 이외의 염기를 포함하는 뉴클레오티드를 포함하는 폴리뉴클레오티드를 포함할 수 있다. 폴리뉴클레오티드에 대한 변형은 합성, 비천연 뉴클레오시드를 포함하는 폴리뉴클레오티드, 예를 들어, LNA(locked nucleic aicd)를 포함한다. 폴리뉴클레오티드에 대한 변형은 RNA의 안정성을 증가시키거나 감소시키기 위해 활용될 수 있다. 변형된 폴리뉴클레오티드의 예는 1-메틸 슈도-우리딘을 포함하는 mRNA이다. 변형된 폴리뉴클레오티드의 예 및 그의 용도에 대해, 참조에 의해 본원에 포함된, US 특허 8,278,036, PCT 국제 공개 WO/2015/006747, 및 Weissman 및 Kariko(2015)를 참조한다.
본원에서 사용된, 서열번호에 기재된 "연속 뉴클레오티드(contiguous nucleotide)"는 임의의 개재(intervening) 뉴클레오티드 없이 서열번호에 기재된 순서의 뉴클레오티드의 서열의 뉴클레오티드를 의미한다.
본 발명의 구체예에서, 가이드 서열 부분은 길이가 17 내지 50개 뉴클레오티드일 수 있고, 서열번호 1-10736 중 어느 하나에 제시된 서열의 20-22개의 연속 뉴클레오티드를 포함할 수 있다. 본 발명의 구체예에서, 상기 가이드 서열 부분은 길이가 22개 뉴클레오티드 미만일 수 있다. 예를 들어, 본 발명의 구체예에서, 상기 가이드 서열 부분은 길이가 17, 18, 19, 20 또는 21개 뉴클레오티드일 수 있다. 이러한 구체예에서, 상기 가이드 서열 부분은 서열번호 1-10736 중 어느 하나에 제시된 17-22개의 연속 뉴클레오티드 서열에서 각각 17, 18, 19, 20 또는 21개의 뉴클레오티드로 구성될 수 있다. 예를 들어, 서열번호 10739에 제시된 17개의 연속 뉴클레오티드의 서열에서 17개의 뉴클레오티드를 갖는 가이드 서열 부분은 하기 뉴클레오티드 서열 중 어느 하나로 구성될 수 있다(연속 서열에서 제외된 뉴클레오티드는 취소선(strike-through)으로 표시됨):
본 발명의 구체예에서, 가이드 서열 부분은 길이가 20개 초과의 뉴클레오티드일 수 있다. 예를 들어, 본 발명의 구체예에서, 가이드 서열 부분은 길이가 21, 22, 23, 24, 25, 26, 27, 28, 29 또는 30개 뉴클레오티드일 수 있다. 이러한 구체예에서, 가이드 서열 부분은 서열번호 1-10736 중 어느 하나에 제시된 20개, 21개 또는 22개 연속 뉴클레오티드의 서열을 포함하는 17-50개의 뉴클레오티드 및 표적 서열의 3' 말단, 표적 서열의 5' 말단, 또는 둘 다에 인접한 뉴클레오티드 또는 뉴클레오티드 서열에 완전히 상보적인 추가 뉴클레오티드를 포함한다.
본 발명의 구체예에서, CRISPR 뉴클레아제와 가이드 서열 부분을 포함하는 RNA 분자는 표적 DNA 서열에 결합하여 표적 DNA 서열을 절단하는 CRISPR 복합체를 형성한다. CRISPR 뉴클레아제, 예를 들면, Cpf1은 추가 tracrRNA 분자 없이 CRISPR 뉴클레아제 및 RNA 분자를 포함하는 CRISPR 복합체를 형성할 수 있다. 대안적으로, CRISPR 뉴클레아제, 예를 들어 Cas9는 CRISPR 뉴클레아제, RNA 분자 및 tracrRNA 분자 간에 CRISPR 복합체를 형성할 수 있다. 특정 표적 DNA 서열에 혼성화할 수 있는 뉴클레오티드 서열을 포함하는 가이드 서열 부분, 및 CRISPR 뉴클레아제 결합에 참여하는 서열 부분, 예를 들어 tracrRNA 서열 부분은 동일한 RNA 분자 상에 위치할 수 있다. 대안적으로, 가이드 서열 부분은 하나의 RNA 분자에 위치할 수 있고 CRISPR 뉴클레아제 결합에 참여하는 서열 부분, 예를 들어 tracrRNA 부분은 별개의 RNA 분자에 위치할 수 있다. 가이드 서열 부분(예: DNA 표적화 RNA 서열) 및 적어도 하나의 CRISPR 단백질 결합 RNA 서열 부분(예: tracrRNA 서열 부분)을 포함하는 단일 RNA 분자는 CRISPR 뉴클레아제와 복합체를 형성하고 DNA-표적화 분자로 역할을 할 수 있다. 일부 구체예에서, 가이드 서열 부분을 포함하는 DNA-표적화 RNA 부분을 포함하는 제1 RNA 분자와 CRISPR 단백질-결합 RNA 서열을 포함하는 제2 RNA 분자는 염기쌍 형성에 의해 상호작용하여 CRISPR 뉴클레아제를 DNA 표적 부위로 표적화는 RNA 복합체를 형성하거나, 대안적으로 함께 융합되어 CRISPR 뉴클레아제와 복합체를 형성하고 CRISPR 뉴클레아제를 DNA 표적 부위로 표적화하는 RNA 분자를 형성한다.
본 발명의 구체예에서, 가이드 서열 부분을 포함하는 RNA 분자는 tracrRNA 분자의 서열을 추가로 포함할 수 있다. 이러한 구체예는 RNA 분자의 가이드 부분과 트랜스 활성화 crRNA(tracrRNA)의 합성 융합체(synthetic fusion)로 설계될 수 있다. (Jinek et al., 2012 참조). 이러한 구체예에서, RNA 분자는 단일 가이드 RNA(sgRNA) 분자이다. 본 발명의 구체예는 또한 별개의 tracrRNA 분자 및 가이드 서열 부분을 포함하는 별개의 RNA 분자를 활용하여 CRISPR 복합체를 형성할 수 있다. 이러한 구체예에서, tracrRNA 분자는 염기쌍 형성을 통해 RNA 분자와 혼성화할 수 있고, 본원에 기술된 본 발명의 특정 적용에 유리할 수 있다.
용어 "tracr 메이트 서열(tracre mate sequence)"은 염기쌍을 통해 tracrRNA에 혼성화하고 CRISPR 복합체의 형성을 촉진하도록 tracrRNA 분자에 충분히 상보적인 서열을 의미한다. (미국 특허 번호 8,906,616 참조). 본 발명의 구체예에서, RNA 분자는 tracr 메이트 서열을 갖는 부분을 추가로 포함할 수 있다.
본 개시의 목적상 "유전자"는 유전자 산물을 코딩하는 DNA 영역, 및 유전자 산물의 생산을 조절하는 조절 서열이 코딩 및/또는 전사된 서열에 인접한지 여부에 관계없이, 유전자 산물의 생산을 조절하는 모든 DNA 영역을 포함한다. 따라서, 유전자는 프로모터 서열, 종결자(terminator), 번역 조절 서열, 예를 들면, 리보솜 결합 부위 및 내부 리보솜 진입 부위(internal ribosome entry site), 인핸서, 사일런서(silencer), 인슐레이터(insulator), 경계 요소(boundary element), 복제 기원, 매트릭스 부착 부위(matrix attachment site) 및 유전자좌 조절 영역(locus control region)을 포함하나, 반드시 이에 한정되는 것은 아니다.
"진핵" 세포는 진균 세포(예: 효모), 식물 세포, 동물 세포, 포유동물 세포 및 인간 세포를 포함하나, 이에 한정되지 않는다.
본원에서 사용된, 용어 "뉴클레아제"는 핵산의 뉴클레오티드 서브유닛 사이의 포스포디에스테르 결합을 절단할 수 있는 효소를 지칭한다. 뉴클레아제는 천연 공급원으로부터 단리되거나 유래될 수 있다. 천연 공급원은 임의의 살아있는 유기체일 수 있다. 대안적으로, 뉴클레아제는 포스포디에스테르 결합 절단 활성을 유지하는 변형된 또는 합성 단백질일 수 있다. 유전자 변형은 뉴클레아제, 예를 들어 CRISPR 뉴클레아제를 사용하여 달성될 수 있다.
본 발명의 구체예에 따르면, 세포에서 내인성 저밀도 지질단백질 수용체(LDLR) 유전자의 발현을 증가시키는 방법이 제공되며, 상기 방법은 LDLR 유전자 또는 LDLR 유전자에 의해 코딩된 전사체를 변형시키는 것을 포함한다.
일부 구체예에서, 세포에서 내인성 LDLR 유전자의 발현 증가는 LDLR 유전자의 변형 전 세포 내 LDLR 전사체 수준 또는 LDLR 단백질 수준 대비 LDLR 전사체 수준 또는 LDLR 단백질 수준의 10% 이상, 25% 이상, 50% 이상, 75% 이상, 100% 이상, 150% 이상, 200% 이상, 250% 이상, 300% 이상, 350% 이상, 400% 이상, 450% 이상, 500% 이상, 550% 이상, 또는 600% 이상 증가로 측정된다. 전사체 수준(예를 들어 qRT-PCR) 및 단백질 수준(예를 들어 항체 염색, 유동 세포 측정법)을 측정하는 방법은 당업계에서 공지되어 있다.
일부 구체예에서, 내인성 LDLR 유전자의 발현 증가는 LDLR 유전자가 변형되기 전의 세포에 의한 LDL-C 흡수 대비 LDL-C 흡수의 적어도 10%, 적어도 25%, 적어도 50%, 적어도 75%, 적어도 100%, 적어도 150%, 적어도 200%, 적어도 250%, 적어도 300%, 적어도 350%, 적어도 400%, 적어도 450%, 또는 적어도 500% 증가를 가져온다.
일부 구체예에서, LDLR 유전자는 CRISPR 뉴클레아제, 메가뉴클레아제(meganuclease), TALEN(transcription activator-like effector nuclease), 또는 ZFN(zinc finger nuclease)에 의해 변형되거나, LDLR 유전자에 의해 코딩된 전사물은 siRNA(small interfering RNA), shRNA(short hairpin RNA) 또는 miRNA(microRNA) 분자에 의해 변형된다.
일부 구체예에서, LDLR 유전자 또는 LDLR 유전자에 의해 코딩된 전사체의 3' 비번역 영역(UTR)이 변형된다. 예를 들어, LDLR 유전자의 전사체는 siRNA 분자가 전사체에 결합함으로써 변형될 수 있다. 전사체의 이러한 변형은 전사체의 3' UTR에 대한 접근성을 차단하기 위해 수행될 수 있다.
일부 구체예에서, LDLR 유전자의 3'UTR은 3'UTR 또는 그의 일부의 절제(excision)에 의해 변형된다. 일부 구체예에서, LDLR 유전자의 3'UTR 영역이 절제된다. 일부 구체예에서, 3' UTR의 절제된 영역의 5' 말단은 LDLR 정지 코돈의 말단의 하류 적어도 1, 2, 5, 10, 15, 20, 30, 40, 50, 60개 뉴클레오티드에 위치하고, 3' UTR의 절제된 영역의 3' 말단은 내인성 LDLR 폴리아데닐화 신호의 상류 적어도 1, 2, 5, 10, 15 20, 25, 30, 40, 50, 60개 뉴클레오티드에 위치한다. 각 가능성은 개별 구체예를 나타낸다. 일부 구체예에서, 3'UTR의 절제된 영역은 LDLR 유전자의 정지 코돈에 대해 하류로 적어도 30개 뉴클레오티드이고, 폴리아데닐화 신호에 대해 상류로 적어도 30개 뉴클레오티드이다. 일부 구체예에서, LDLR 유전자의 3'UTR의 절제된 영역은 폴리아데닐화 신호의 상류 적어도 500, 450, 400, 300, 200개 뉴클레오티드("염기쌍(bp)"로도 지칭됨)부터 폴리아데닐화 신호의 상류 100, 90, 70, 80, 70, 60개 뉴클레오티드에 이르는 영역의 절제를 포함한다. 각 가능성은 별도의 구체예를 나타낸다. 일부 구체예에서, LDLR 3'UTR의 절제된 영역은 적어도 폴리아데닐화 신호의 상류 500개 뉴클레오티드부터 폴리아데닐화 신호의 상류 60개 뉴클레오티드에 이르는 영역의 절제를 포함한다. 일부 구체예에서, LDLR 유전자의 3'UTR의 절단된 영역은 적어도 정지 코돈의 하류 800, 900, 1000, 1100, 1200, 1300, 1400, 1500개 뉴클레오티드부터 폴리아데닐화 신호의 상류 200, 100, 90, 70, 60, 50개 뉴클레오티드에 이르는 영역의 절제를 포함한다. 각 가능성은 별도의 구체예를 나타낸다. 일부 구체예에서, LDLR 유전자의 3'UTR의 절제된 영역은 적어도 정지 코돈의 하류 800개 뉴클레오티드부터 폴리아데닐화 신호의 상류 60개 뉴클레오티드에 이르는 영역의 절제를 포함한다. 일부 구체예에서, LDLR 유전자의 3'UTR의 절재된 영역은 적어도 정지 코돈의 하류 100-300개 뉴클레오티드부터 폴리아데닐화 신호의 상류 170-30개 뉴클레오티드에 이르는 영역의 절단을 포함한다. 일부 구체예에서, LDLR 유전자의 3'UTR의 절제된 영역은 적어도 정지 코돈의 하류 175개 뉴클레오티드부터 폴리아데닐화 신호의 상류 70개 뉴클레오티드에 이르는 영역의 절제를 포함한다. 일부 구체예에서, LDLR 유전자의 3'UTR의 절제된 영역은 적어도 정지 코돈의 하류 230개 뉴클레오티드부터 폴리아데닐화 신호의 상류 70개 뉴클레오티드에 이르는 영역의 절제를 포함한다.
일부 구체예에서, 상기 방법은:
적어도 하나의 CRISPR 뉴클레아제, 또는 상기 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 분자; 및
가이드 서열을 포함하는 RNA 분자, 또는 상기 RNA 분자를 코딩하는 DNA 분자를 포함하는 조성물을 상기 세포에게 투여하는 단계를 포함하고,
상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체는 상기 LDLR 유전자의 대립유전자에서 이중가닥 절단을 생성하여, 상기 LDLR 유전자의 발현을 증가시킨다.
일부 구체예에서, LDLR의 3' UTR에 위치한 miRNA 결합 부위 또는 AU 풍부 영역(AU Rich region: AUR)과 같은 LDLR 발현 억제에 관여하는 하나 이상의 부위가 불활성화되고, 결과적으로 LDLR의 발현이 증가된다.
일부 구체예에서, 상기 조성물은 개체의 세포 또는 배양물 내의 세포에 도입된다.
일부 구체예에서, 상기 세포는 간 세포이다. 일부 구체예에서, 상기 세포는 헤파토사이트이다. 일부 구체예에서, 상기 세포는 줄기 세포이다.
일부 구체예에서, 상기 CRISPR 뉴클레아제 및 RNA 분자, 또는 상기 RNA 분자를 코딩하는 뉴클레오티드 분자(예: DNA 분자)는 실질적으로 동시에 또는 서로 다른 시간에 세포에 도입된다.
일부 구체예에서, 세포 내 LDLR 유전자의 miRNA 결합 부위 또는 AU 풍부 영역(AUR)은 삽입 또는 결실 돌연변이에 노출된다. 일부 구체예에서, 적어도 하나의 miRNA 결합 부위 또는 AU 풍부 영역(AUR)은 세포의 LDLR 대립유전자 중 하나 또는 둘 모두로부터 완전히 절제된다.
일부 구체예에서, RNA 분자의 가이드 서열 부분은 정지 코돈의 하류 또는 폴리아데닐화 신호의 상류에 위치한 LDLR 3'UTR의 부위를 표적으로 한다. 일부 구체예에서, RNA 분자의 가이드 서열 부분은 정지 코돈의 말단의 하류 적어도 1, 2, 5, 10, 15, 20, 30, 40, 50개 뉴클레오티드, 또는 폴리아데닐화 신호의 상류 적어도 1, 2, 5, 10, 15, 20, 25, 30, 40, 50개 뉴클레오티드에 위치한 LDLR 3'UTR의 부위를 표적으로 한다. 각 가능성은 별도의 구체예를 나타낸다. 일부 구체예에서, RNA 분자의 가이드 서열 부분은 정지 코돈에 대해 적어도 30개 뉴클레오티드 하류 또는 폴리아데닐화 신호에 대해 적어도 30개 뉴클레오티드 상류에 위치한 LDLR 3'UTR의 부위를 표적으로 한다.
일부 구체예에서, RNA 분자의 가이드 서열 부분은 LDLR 대립유전자의 miRNA 결합 부위를 표적으로 한다.
일부 구체예에서, RNA 분자의 가이드 서열 부분은 miR-85 또는 miR-148 결합 부위를 표적으로 한다.
일부 구체예에서, miR 시드 서열(seed sequence)은 LDLR 유전자의 대립유전자에서 이중가닥 절단의 결과로 불활성화된다.
일부 구체예에서, miR 시드 서열은 UGGUGCUA 또는 CACUGUG이다.
일부 구체예에서, miR 시드 서열은 miR-185 또는 miR-148 시드 서열이다.
일부 구체예에서, CRISPR 뉴클레아제와 RNA 분자의 복합체는 LDLR 유전자의 두 대립유전자 모두에서 이중가닥 절단을 형성한다.
일부 구체예에서, RNA 분자의 가이드 서열 부분은 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함한다.
일부 구체예에서, 세포에 도입된 조성물은 가이드 서열 부분을 포함하는 제2 RNA 분자, 또는 제2 RNA 분자를 코딩하는 뉴클레오티드 분자(예를 들어 DNA 분자)를 추가로 포함한다.
일부 구체예에서, 제2 RNA의 가이드 서열 부분은 정지 코돈에 대해 적어도 30개 뉴클레오티드 하류 또는 폴리아데닐화 신호에 대해 적어도 30개 뉴클레오티드 상류에 위치한 LDLR 3'UTR 내의 부위를 표적화한다.
일부 구체예에서, 제2 RNA 분자의 가이드 서열 부분은 제1 RNA 분자의 서열 이외의 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함한다.
일부 구체예에서, LDLR 3'UTR 또는 그의 일부는 CRISPR 뉴클레아제와 제1 RNA 분자에 의해 형성된 이중가닥 절단 및 CRISPR 뉴클레아제와 제2 RNA 분자에 의해 형성된 이중가닥 절단에 의해 절제된다. 일부 구체예에서, LDLR 3'UTR 서열의 적어도 일부를 포함하는 서열이 절제된다. 일부 구체예에서, LDLR 3'UTR 서열을 포함하는 서열이 절제된다.
비한정적인 예로서, LDLR 3'UTR의 일부는 OMNI-50 CRISPR 뉴클레아제(서열번호 10749) 및 서열번호 7707을 포함하는 가이드 서열 부분을 포함하는 제1 RNA 분자를 포함하는 제1 CRISPR 복합체와 OMNI-50 CRISPR 뉴클레아제(서열번호 10749) 및 서열번호 9843을 포함하는 가이드 서열 부분을 포함하는 제2 RNA 분자를 포함하는 제2 CRISPR 복합체의 조합된 활성에 의해 절제될 수 있다.
또 다른 비한정적인 예에서, LDLR 3'UTR의 일부는 OMNI-79 CRISPR 뉴클레아제(서열번호 10744) 및 서열번호 7871을 포함하는 가이드 서열 부분을 포함하는 제1 RNA 분자를 포함하는 제1 CRISPR 복합체와 OMNI-79 CRISPR 뉴클레아제(서열번호 10744) 및 서열번호 9843을 포함하는 가이드 서열 부분을 포함하는 제2 RNA 분자를 포함하는 제2 CRISPR 복합체의 조합된 활성에 의해 절제될 수 있다.
따라서, 특정 가이드 서열 부분은 LDLR 3'UTR의 일부를 절제하기 위해 조합하여 사용될 수 있다. 하기 구체예는 LDLR 유전자의 발현을 증가시키기 위해 절제될 수 있는 LDLR 3' UTR 부분의 여러 비한정적인 예를 제공한다. 열거된 표시된 게놈 위치는 gnomAD v3 데이터베이스 및 UCSC Genome Browser assembly ID: hg38, Sequencing/Assembly provider ID: Genome Reference Consortium Human GRCh38.p12(GCA_000001405.27) Assembly date: 2013년 12월, 최초 출시(initial release); 2017년 12월 patch release 12에 근거한다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11131463 내지 19:11133279에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 절제하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 1120을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 2656을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11131463 내지 19:11133713에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 제거하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 1120을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 796을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11131463 내지 19:11132114에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 제거하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 1120을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 477을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11131463 내지 19:11132115에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 제거하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 1120을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 1913을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11131516 내지 19:11133713에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 절제하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 181을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 796을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11131557 내지 19:11131567에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 절제하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 901을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 1927을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11133279 내지 19:11133713에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 절제하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 2656을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 796을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11133713 내지 19:11132114에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 절제하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 796을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 477을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11133713 내지 19:11132115에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 절제하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 796을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 1913을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11131467 내지 19:11133713에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 절제하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 7871을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 9843을 포함할 수 있다.
일부 구체예에서, LDLR 3'UTR의 절제된 부분은 대략 19:11131519 내지 19:11133713에 걸쳐 있다. 예를 들어, LDLR 3'UTR로부터 이러한 부분을 절제하기 위해, 제1 RNA 분자의 가이드 서열 부분은 서열번호 7707을 포함할 수 있고, 제2 RNA 분자의 가이드 서열 부분은 서열번호 9843을 포함할 수 있다.
일부 구체예에서, 내인성 LDLR 폴리아데닐화 신호는 온전하게 유지된다.
일부 구체예에서, 제1 RNA 분자 또는 제2 RNA 분자의 가이드 서열 부분은 완전히 상보적인 LDLR 표적 서열 대비 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함한다.
일부 구체예에서, 가이드 서열 부분은 완전히 상보적인 LDLR 표적 서열 대비 1, 2, 3, 4, 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함한다.
일부 구체예에서, 완전히 상보적인 LDLR 표적 서열에 비해 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 가이드 서열 부분은 LDLR 유전자의 돌연변이 대립유전자에 대해 더 높은 상보성을 갖는 가이드 서열 부분에 비해 CRISPR 뉴클레아제와 제1 RNA 분자의 복합체에 더 높은 표적화 특이성을 제공한다.
일부 구체예에서, 세포에서 내인성 LDLR 유전자의 발현 증가는 LDLR 유전자의 변형 전 세포 내 LDLR 전사체 수준 또는 LDLR 단백질 수준 대비 LDLR 전사체 수준 또는 LDLR 단백질 수준의 10% 이상, 25% 이상, 50% 이상, 75% 이상, 100% 이상, 150% 이상, 200% 이상, 250% 이상, 300% 이상, 350% 이상, 400% 이상, 450% 이상, 500% 이상 증가, 550% 이상 증가, 또는 600% 이상 증가로 측정된다.
일부 구체예에서, 내인성 LDLR 유전자의 발현 증가는 LDLR 유전자가 변형되기 전의 세포에 의한 LDL-C 흡수 대비 세포에 의한 LDL-C 흡수의 적어도 10%, 적어도 25%, 적어도 50%, 적어도 75%, 적어도 100%, 적어도 150%, 적어도 200%, 적어도 250%, 적어도 300%, 적어도 350%, 적어도 400%, 적어도 450%, 또는 적어도 500% 증가를 초래한다.
본 발명의 구체예에 따르면, 서열번호 1-10736 중 어느 하나, 또는 완전히 상보적인 LDLR 표적 서열 대비 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1-10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함하는 RNA 분자, 또는 상기 RNA 분자를 코딩하는 DNA 분자를 포함하는 조성물이 제공된다.
일부 구체예에서, 상기 조성물은 CRISPR 뉴클레아제, 또는 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 분자를 추가로 포함한다.
일부 구체예에서, 상기 조성물은 tracrRNA 분자를 추가로 포함한다.
일부 구체예에서, 상기 조성물은 가이드 서열 부분을 포함하는 제2 RNA 분자, 또는 상기 제2 RNA 분자를 코딩하는 DNA 분자를 추가로 포함한다.
일부 구체예에서, 제2 RNA의 가이드 서열 부분은 정지 코돈의 하류 적어도 30개 뉴클레오티드 또는 폴리아데닐화 신호의 상류 적어도 30개 뉴클레오티드에 위치한 LDLR 3'UTR 내의 부위를 표적화한다.
일부 구체예에서, 제2 RNA 분자의 가이드 서열 부분은 제1 RNA 분자의 서열 을 제외한 서열번호 1-10736 중 어느 하나, 완전히 상보적인 LDLR 표적 서열에 비해 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 제1 RNA 분자의 서열을 제외한 서열번호 1-10736 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함한다.
본 발명의 일부 구체예에 따르면, 본원에 기술된 방법 중 어느 하나에 따라 변형되거나 본원에 기술된 조성물 중 어느 하나를 사용하여 변형된 세포가 제공된다.
본 발명의 일부 구체예에 따르면, 세포에서 LDLR 대립유전자를 불활성화하는데 사용하기 위한 본원에 기재된 구체예 중 어느 하나의 조성물을 포함하는 약제로서, 상기 약제는 세포에 상기 조성물을 전달하는 것에 의해 투여되는 것인 약제가 제공된다.
본 발명의 일부 구체예에 따르면, 고콜레스테롤혈증을 치료, 개선 또는 예방하기 위한, 본원에 기재된 구체예 중 어느 하나의 조성물 또는 본원에 기재된 변형된 세포의 용도로서, 고콜레스테롤혈증을 경험하거나 경험할 위험이 있는 개체에게 상기 조성물 또는 변형된 세포를 전달하는 것을 포함하는 것인 용도가 제공된다.
본 발명의 일부 구체예에 따르면, 고콜레스테롤혈증을 치료, 개선 또는 예방하는데 사용하기 위한, 본원에 기재된 구체예 중 어느 하나의 조성물 또는 본원에 기재된 변형된 세포를 포함하는 약제가 제공되고, 상기 약제는 고콜레스테롤혈증을 경험하고 있거나, 경험할 위험이 있는 개체에게 상기 조성물 또는 변형된 세포를 전달하는 것에 의해 투여된다.
본 발명의 일부 구체예에 따르면, 본원에 기재된 구체예 중 어느 하나의 조성물 및 상기 조성물을 세포에 전달하기 위한 설명서를 포함하는, 세포에서 LDLR 발현을 증가시키기 위한 키트가 제공된다.
본 발명의 일부 구체예에 따르면, 본원에 기재된 구체예 중 어느 하나의 조성물 또는 본원에 기재된 변형된 세포, 및 고콜레스테롤혈증을 경험하고 있거나 경험할 위험이 있는 개체에게 상기 조성물 또는 변형된 세포를 전달하기 위한 설명서를 포함하는, 개체에서 고콜레스테롤혈증을 치료 또는 예방하기 위한 키트가 제공된다.
본 발명의 구체예에 따르면, 본원에 기술된 조성물 또는 변형된 세포 중 어느 하나를 고콜레스테롤혈증(예: 가족성 고콜레스테롤혈증)을 경험하고 있거나 경험할 위험이 있는 개체에게 전달하는 것을 포함하는, 고콜레스테롤혈증(예를 들어, 가족성 고콜레스테롤혈증)을 치료, 개선 또는 예방하기 위한 본원에 기술된 조성물 또는 변형된 세포 중 어느 하나의 용도가 제공된다.
본 발명의 구체예에 따르면, 고콜레스테롤혈증(예를 들어, 가족성 고콜레스테롤혈증)을 치료, 개선 또는 예방하기 위해 본원에 기술된 조성물 또는 변형된 세포 중 어느 하나를 포함하는 약제가 제공되며, 상기 약제는 상기 조성물 또는 변형된 세포를 고콜레스테롤혈증(예: 가족성 고콜레스테롤혈증)을 경험하고 있거나 경험할 위험이 있는 개체에 전달하는 것에 의해 투여된다.
본 발명의 구체예에 따르면, 개체에서 고콜레스테롤혈증(예: 가족성 고콜레스테롤혈증)을 치료, 개선 또는 예방하기 위해 세포(예: 간 세포 또는 헤파토사이트)를 변형하는 데 사용하기 위한 RNA 분자가 제공된다. 상기 RNA 분자는 생체외, 시험관내 또는 생체내에서 세포로 전달될 수 있다.
본 발명의 구체예에 따르면, 본원에 기재된 조성물 중 어느 하나 및 상기 조성물을 세포에 전달하기 위한 설명서를 포함하는, 세포에서 LDLR 대립유전자의 miRNA 결합 부위 및/또는 AUR(Au Rich Region)을 불활성화시키기 위한 키트가 제공된다.
본 발명의 구체예에 따르면, 본 명세서에 기재된 조성물 중 어느 하나 및 상기 조성물을 고콜레스테롤혈증(예: 가족성 고콜레스테롤혈증)을 경험하고 있거나 경험할 위험이 있는 개체에게 전달하기 위한 설명서를 포함하는, 개체에서 고콜레스테롤혈증(예: 가족성 고콜레스테롤혈증)을 치료, 개선 또는 예방하기 위한 키트가 제공된다.
본 발명의 구체예에 따르면, 서열번호 1-10736 중 어느 하나, 또는 완전히 상보적인 LDLR 표적 서열에 비해 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1-10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함하는 RNA 분자를 포함하는 조성물이 제공된다.
일부 구체예에서, 상기 조성물은 CRISPR 뉴클레아제 또는 그의 기능적 유도체(functional derivative)를 추가로 포함한다.
일부 구체예에서, 상기 조성물은 tracrRNA 분자를 추가로 포함한다.
본 발명의 구체예에 따르면, 서열번호 1-10736 중 어느 하나, 또는 완전히 상보적인 LDLR 표적 서열에 비해 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1-10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함하는 RNA 분자, 또는 이를 코딩하는 뉴클레오티드 분자(예를 들면, DNA 분자)를 포함하는 유전자 편집 조성물이 제공된다. 일부 구체예에서, 상기 RNA 분자는 CRISPR 뉴클레아제에 결합하는 서열을 갖는 부분을 추가로 포함한다. 일부 구체예에서, 상기 CRISPR 뉴클레아제에 결합하는 서열은 tracrRNA 서열이다.
일부 구체예에서, 상기 RNA 분자는 tracr 메이트 서열을 갖는 부분, 또는 이를 코딩하는 분자를 추가로 포함한다.
일부 구체예에서, 상기 RNA 분자는 하나 이상의 링커 부분을 추가로 포함할 수 있다.
본 발명의 구체예에 따르면, RNA 분자는 최대 1000, 900, 800, 700, 600, 500, 450, 400, 350, 300, 290, 280, 270, 260, 250, 240, 230, 220, 210, 200, 190, 180, 170, 160, 150, 140, 130, 120, 110 또는 100개 뉴클레오티드 길이일 수 있다. 각 가능성은 별개의 구체예를 나타낸다. 본 발명의 구체예에서, 상기 RNA 분자는 17개 내지 최대 300개 뉴클레오티드 길이, 100개 내지 최대 300개 뉴클레오티드 길이, 150개 내지 300개 뉴클레오티드 길이, 100개 내지 500개 뉴클레오티드 길이, 100개 내지 400개 뉴클레오티드 길이, 200개 내지 300개 뉴클레오티드 길이, 100개 내지 200개 뉴클레오티드 길이, 또는 150개 내지 250개 뉴클레오티드 길이일 수 있다. 각 가능성은 별개의 구체예를 나타낸다.
본 발명의 일부 구체예에 따르면, 상기 조성물은 tracrRNA 분자를 추가로 포함한다.
일부 구체예에서, 상기 조성물은 제2 RNA 분자 또는 제2 RNA 분자를 코딩하는 DNA 분자를 추가로 포함한다.
일부 구체예에서, 제2 RNA의 가이드 서열 부분은 정지 코돈에 대해 적어도 30개 뉴클레오티드 하류 또는 폴리아데닐화 신호에 대해 적어도 30개 뉴클레오티드 상류에 위치한 LDLR 3'UTR 내의 부위를 표적화한다.
일부 구체예에서, 제2 RNA 분자의 가이드 서열 부분은 제1 RNA 분자의 서열 외의 서열번호 1-10736 중 어느 하나, 또는 완전히 상보적인 LDLR 표적 서열에 비해 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 제1 RNA 분자의 서열 이외의 서열번호 1-10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함한다.
본 개시의 조성물 및 방법은 고콜레스테롤혈증을 치료, 예방, 개선하거나 또는 그의 진행을 둔화시키기 위해 활용될 수 있다.
세포에서 LDLR 발현을 증가시키거나 LDLR 반감기를 증가시키기 위한 전술된 전략 중 임의의 하나 또는 이들의 조합이 본 발명의 맥락에서 사용될 수 있다.
일부 구체예에서, 상기 방법은 LDLR 유전자의 발현 증가에 의해 중증도가 감소된 질병 표현형인 고콜레스테롤혈증의 위험이 있는 개체를 치료하기 위해 이용된다. 이러한 구체예에서, 상기 방법은 질병 표현형의 개선, 호전 또는 예방을 초래한다.
본원에 기술된 조성물의 구체예는 적어도 하나의 CRISPR 뉴클레아제, RNA 분자(들), 및 tracrRNA 분자를 포함하고, 이들은 개체 또는 세포에서 동시에 효과적이다. 상기 적어도 하나의 CRISPR 뉴클레아제, RNA 분자(들) 및 tracrRNA는 실질적으로 동시에 전달될 수 있거나, 상이한 시간에 전달될 수 있으나, 동시에 효과를 가질 수 있다. 예를 들어, 이는 RNA 분자 및/또는 tracrRNA가 상기 개체 또는 세포에 실질적으로 존재하기 전에, 상기 개체 또는 세포에 CRISPR 뉴클레아제를 전달하는 것을 포함한다.
일부 구체예에서, 인간 세포는 본원에 기재된 방법 중 어느 하나에 의해 변형된다. 일부 구체예에서, 상기 세포는 간세포(liver cell)이다. 일부 구체예에서, 상기 세포는 헤파토사이트(hepatocyte)이다. 일부 구체예에서, 상기 세포는 줄기 세포이다.
LDLR
편집 전략
LDLR 발현을 증가시키기 위해 변형되거나 제거될 수 있는 인간 LDLR 유전자의 특정 영역은 아직 결정되지 않았다. 이전에, Knouff et al. (2001)은 마우스 LDLR 대립유전자를 절단된 인간 LDLR 미니유전자(minigene) 변이체로 대체하도록 변형된 마우스 이형접합체의 간에서 간 LDLR mRNA 수준의 높지 않은(modest) 증가를 보여주었다. 또한 Bjornsson et al. (2021)은 내인성 폴리아데닐화 신호를 포함한 LDLR 3'UTR의 원위 영역(distal region)에 걸쳐 있고 LDLR 유전자를 훨씬 넘어 확장되는 2.5 kb 결실 돌연변이의 여러 담체(carrier)를 포함하는 단일 패밀리를 확인했고, 이들은 기능 획득(gain-of-function) 효과를 제공하는 것으로 보였다. 그러나, 예를 들어, CRISPR 뉴클레아제를 특정 부위에 표적화함으로써 인간 LDLR 3'UTR의 특정 부분을 표적화하고 제거하는 전략과 그러한 돌연변이가 LDLR 발현 및 콜레스테롤 수준에 미치는 영향은 부재했다.
본 발명은 예를 들어, 개체의 세포에서 조절 인자 부위를 제거 또는 불활성화하거나 하나 이상의 LDLR 대립유전자의 3' UTR 부분을 절제함으로써 LDLR 유전자의 발현을 증가시켜 고콜레스테롤혈증(예를 들어, 가족성 고콜레스테롤혈증)을 치료 또는 예방하는 방법을 제공한다. 따라서, 본원에서 제공된 세포에서 LDLR 대립유전자 내의 조절 인자 부위를 녹아웃시키거나 불활성화시키는 방법은 고콜레스테롤혈증(예를 들어, 가족성 고콜레스테롤혈증)을 치료, 예방 또는 개선하기 위해 이용될 수 있다. 일부 구체예에서, 상기 조절 인자 부위는 miRNA 결합 부위 또는 AU 풍부 영역(AUR)이다.
LDLR 편집 전략은 CRISPR 뉴클레아제를 LDLR의 3'UTR에 있는 miRNA(microRNA) 결합 부위로 표적화하는 가이드 서열 부분을 포함하는 RNA 분자를 활용하는 것을 포함하나, 이에 한정되지 않는다. 예를 들어, 가이드 서열 부분은 miR-185 시드 서열 또는 miR-148 시드 서열을 표적화할 수 있다. 이러한 시드 부위(seed site)를 편집하면 3'UTR에 대한 miRNA의 결합이 제거되어 LDLR mRNA 수준 및/또는 LDLR 단백질 수준이 상향 조절된다.
또 다른 전략은 각각 LDLR 3'UTR 중 서열에 CRISPR 뉴클레아제를 표적화하는 독특한 가이드 서열 부분을 포함하는, 두 개의 RNA 분자를 활용하는 것을 포함한다. 3'UTR의 적어도 일부의 이중 대립유전자 절제(biallelic excision)를 달성하기 위해, 2개의 표적화된 서열 중 제1 서열은 LDLR 종결 코돈의 하류에 위치할 수 있고, 2개의 서열 중 제2 서열은 폴리아데닐화 신호의 상류에 위치할 수 있다. 이러한 서열은 정지 코돈에 대해 적어도 30개 뉴클레오티드 하류 또는 폴리아데닐화 신호에 대해 적어도 30개 뉴클레오티드 상류에 위치할 수 있다. 이러한 방식으로 대부분의 3'UTR의 이중 대립유전자 절제가 달성된다. 따라서, LDLR의 발현을 음성적으로 조절하는 miRNA 결합 부위 또는 AUR(AU Rich Region) 조절 부위가 비활성화되거나 제거된다. 일부 구체예에서, 이는 전사체의 안정성 및 번역 효율성에 필수적인, 온전한 폴리아데닐화 신호를 갖는 절단된 3'UTR을 유지하면서 달성된다. 다른 구체예에서, 폴리아데닐화 신호는 또한 적어도 부분적으로 제거된다.
따라서, 하나의 전략은 3'UTR의 서열을 표적으로 하는 독특한 가이드 서열 부분을 각각 포함하는 2개의 가이드 RNA 분자와 적어도 하나의 CRISPR 뉴클레아제를 활용하여 LDLR 유전자의 3'UTR, 또는 LDLR 유전자의 3' UTR의 적어도 일부를 포함하는 서열을 절제하는 것을 포함한다. 이러한 서열은 폴리아데닐화 신호의 하류 또는 정지 코돈의 상류에 위치할 수 있다. 3'UTR의 적어도 일부 또는 전체 3'UTR을 포함하는 이중 대립유전자 절제를 달성하기 위해 표적화될 수 있는 서열의 비한정적 예는 1) 정지 코돈의 상류에 위치한 제1 서열 및 폴리아데닐화 신호의 상류에 위치한 제2 서열; 2) 정지 코돈의 하류에 위치한 제1 서열 및 폴리아데닐화 신호의 하류에 위치한 제2 서열; 및 3) 정지 코돈의 상류에 위치한 제1 서열 및 폴리아데닐화 신호의 하류에 위치한 제2 서열을 포함한다.
가이드 서열 부분을 포함하는 RNA 분자 중 어느 하나는 단일 가이드 RNA(sgRNA) 분자 또는 CRISPR RNA(crRNA) 분자일 수 있다. 전형적으로, crRNA 분자는 당업계에 기술된 바와 같이, CRISPR 뉴클레아제를 표적화하기 위해 트랜스활성화 crRNA(tracrRNA) 분자와 함께 활용된다. 따라서, 표시된 전략 각각은 하나 이상의 단일 가이드 RNA 분자 및/또는 하나 이상의 crRNA 및 tracrRNA 분자, 또는 이들의 임의의 조합과 함께 하나 이상의 CRISPR 뉴클레아제를 활용하여 수행될 수 있다. 조성물은 핵산 벡터, DNA 분자, RNA 분자, 리보핵산단백질(RNP), 또는 이들의 임의의 조합 중 하나 이상으로서 표적 세포에 도입될 수 있다.
CRISPR 뉴클레아제 및 PAM 인식
일부 구체예에서, 서열 특이적 뉴클레아제는 CRISPR 뉴클레아제 또는 그의 기능적 변이체(functional variant)로부터 선택된다. 일부 구체예에서, 서열 특이적 뉴클레아제는 RNA 가이드 DNA 뉴클레아제(RNA-guided DNA nuclease)이다. 이러한 구체예에서, RNA 가이드 DNA 뉴클레아제(예를 들어, Cpf1)를 가이드하는 RNA 서열은 세포에서 RNA 가이드 DNA 뉴클레아제에 결합하고 및/또는 이를 모든 LDLR 대립유전자로 안내한다. 일부 구체예에서, CRISPR 복합체는 tracrRNA를 추가로 포함하지 않는다. 통상의 기술자는 당업계에 일반적으로 공지된 방법에 의해 RNA 분자가 게놈 내의 선택된 표적에 결합하도록 조작될 수 있다는 것을 인식할 것이다.
본원에서 사용된, 용어 "PAM"은 표적화된 DNA 서열에 근접하게 위치하고 CRISPR 뉴클레아제에 의해 인식되는 표적 DNA의 뉴클레오티드 서열을 지칭한다. PAM 서열은 뉴클레아제 실체(identity)에 따라 다를 수 있다. 또한, 거의 모든 PAM을 표적화할 수 있는 CRISPR 뉴클레아제가 있다. 본 발명의 일부 구체예에서, CRISPR 시스템은 가이드 서열 부분과 표적 인식을 위한 추가적 요건인 프로토스페이서 인접 모티프(PAM) 옆에 있는 DNA 부위인, 표적 DNA 부위 상의 프로토스페이서 사이의 왓슨-크릭(Watson-Crick) 염기쌍 결합을 통해 CRISPR 뉴클레아제를 표적 DNA 부위로 지시하기 위해 가이드 서열 부분을 갖는 하나 이상의 RNA 분자를 이용한다. 그 후, CRISPR 뉴클레아제는 표적 DNA 부위의 절단을 매개하여 프로토스페이서 내에서 이중가닥 절단을 생성한다. 비한정적 예에서, 타입 II CRISPR 시스템은 CRISPR 뉴클레아제, 예를 들면, Cas9을 crRNA의 가이드 서열 부분과 프로토스페이서 인접 모티프(PAM) 옆에 있는 표적 DNA의 프로토스페이서 사이의 Watson-Crick 염기쌍 형성을 통해 표적 DNA로 지시하는 성숙한 crRNA:tracrRNA 복합체를 이용한다. 통상의 기술자는 본 발명의 조작된 RNA 분자 각각이 프로토스페이서 인접 모티프(PAM) 옆의 목적 표적 게놈 DNA 서열, 예를 들어 이용되는 CRISPR 뉴클레아제의 타입에 적합한 서열과 일치하는 PAM과 회합하도록 추가로 설계된다는 것을 이해할 것이다. 이용되는 CRISPR 뉴클레아제의 타입에 적합한 서열과 일치하는 PAM의 비한정적 예는 스트렙토코커스 피오게네스 Cas9 WT(SpCAS9)에 대한, "N"은 임의의 핵염기(nucleobse)인 것인 NGG 또는 NAG; 스태필로코커스 아우레우스(SaCas9)에 대한 NNGRRT; 제주니(Jejuni) Cas9 WT에 대한 NNNVRYM; SpCas9-VQR 변이체에 대한 NGAN 또는 NGNG; SpCas9-VRER 변이체에 대한 NGCG; SpCas9-EQR 변이체에 대한 NGAG; SpCas9-NRRH 변이체에 대한, N은 임의의 핵염기이고, R은 A 또는 G이며, H는 A, C 또는 T인 것인 NRRH; SpCas9-NRTH 변이체에 대한, N은 임의의 핵염기이고, R은 A 또는 G이고 H는 A, C 또는 T인 것인 NRTH; SpCas9-NRCH 변이체에 대한, N은 임의의 핵염기이고, R은 A 또는 G이고 H는 A, C 또는 T인 것인 NRCH; SpCas9의 SpG 변이체에 대한, N은 임의의 핵염기인 것인 NG; SpCas9의 NG 변이체에 대한, N은 임의의 핵염기인 것인 NG, 또는 NA; SpCas9의 SpRY 변이체에 대한, N은 임의의 핵염기이고, R은 A 또는 G이고 Y는 C 또는 T인 것인 NR, NRN 또는 NYN; 스트렙토코커스 카니스 Cas9 변이체(ScCas9)에 대한, N은 임의의 핵염기인 것인 NNG; 스태필로코커스 아우레우스의 SaKKH-Cas9 변이체(SaCas9)에 대한, N은 임의의 핵염기이고, R은 A 또는 G인 것인 NNNRRT; 나이세리아 메닌기티디스 (NmCas9)에 대한, N은 임의의 핵염기인 것인 NNNNGATT; 알리시클로바실러스 액시디필루스 Cas12b(AacCas12b)에 대한, N은 임의의 핵염기인 것인 TTN; 또는 Cpfl에 대한, V는 A, C 또는 G인 것인 TTTV이다. 본 발명의 RNA 분자는 각각 하나 이상의 상이한 CRISPR 뉴클레아제와 함께 복합체를 형성하도록 설계되고, 이용된 CRISPR 뉴클레아제에 대해 각각 하나 이상의 상이한 PAM 서열을 이용하여 목적 폴리뉴클레오티드 서열을 표적화하도록 설계된다.
일부 구체예에서, RNA 가이드 DNA 뉴클레아제, 예를 들면, CRISPR 뉴클레아제는 세포의 게놈의 원하는 위치에서 이중 가닥 또는 단일 가닥 DNA 절단을 유발하는 데 사용될 수 있다. 가장 일반적으로 사용되는 RNA 가이드 DNA 뉴클레아제는 CRISPR 시스템에서 유래되나, 기타 RNA 가이드 DNA 뉴클레아제도 본원에 기재된 게놈 편집 조성물 및 방법에 사용하기 위해 고려된다. 예를 들어, 본원에 참조에 의해 포함된, 미국 특허공개번호 2015/0211023을 참조한다.
본 발명의 실시에 사용될 수 있는 CRISPR 시스템은 매우 다양하다. CRISPR 시스템은 타입 I, 타입 II 또는 타입 III 시스템일 수 있다. 적합한 CRISPR 단백질의 비한정적 예는 Cas3, Cas4, Cas5, Cas5e(또는 CasD), Cas6, Cas6e, Cas6f, Cas7, Cas8al, Cas8a2, Cas8b, Cas8c, Cas9, Cas10, Cas10d, CasF, CasG, CasH, Csyl, Csy2, Csy3, Csel(또는 CasA), Cse2(또는 CasB), Cse3(또는 CasE), Cse4(또는 CasC), Cscl, Csc2, Csa5, Csn2, Csm2, Csm3, Csm4, Csm5, Csm6, Cmrl, Cmr3, Cmr4, Cmr5, Cmr6, Csbl, Csb2, Csb3, Csxl7, Csxl4, Csxl0, Csxl6, CsaX, Csx3, Cszl, Csxl5, Csfl, Csf2, Csf3, Csf4 및 Cul966을 포함한다.
일부 구체예에서, RNA 가이드 DNA 뉴클레아제는 타입 II CRISPR 시스템(예: Cas9)에서 유래된 CRISPR 뉴클레아제이다. CRISPR 뉴클레아제는 스트렙토코커스 피오게네스(Streptococcus pyogenes), 스트렙토코커스 써모필루스(Streptococcus thermophilus), 스트렙토코커스 종(Streptococcus sp.), 스태필로코커스 아우레우스(Staphylococcus aureus), 나이세리아 메닌기티디스(Neisseria meningitidis), 트레포네마 덴티콜라(Treponema denticola), 노카르디옵시스 다손빌레이(Nocardiopsis dassonvillei), 스트렙토마이세스 프리스티나에스피랄리스(Streptomyces pristinaespiralis), 스트렙토마이세스 비리도크로모게네스(Streptomyces viridochromogenes), 스트렙토마이세스 비리도크로모게네스, 스트렙토스포란기움 로세움(Streptosporangium roseum), 스트렙토스포란기움 로세움, 알리시클로바실러스 액시도칼다리우스(Alicyclobacillus acidocaldarius), 바실러스 슈도마이코이데스(Bacillus pseudomycoides), 바실러스 셀레니티레두센스(Bacillus selenitireducens), 엑시구오박테리움 시비리쿰(Exiguobacterium sibiricum), 락토바실러스 델브루엑키(Lactobacillus delbrueckii), 락토바실러스 살리바리우스(Lactobacillus salivarius), 마이크로실라 마리나(Microscilla marina), 부르콜데리알레스 박테리움(Burkholderiales bacterium), 폴라로모나스 나프탈레니보란스(Polaromonas naphthalenivorans), 폴라로모나스 종(Polaromonas sp.), 크로코스파에라 와트소니(Crocosphaera watsonii), 시아노테스 종(Cyanothece sp.), 마이크로시스티스 에어루기노사(Microcystis aeruginosa), 시네코코커스 종(Synechococcus sp.), 아세토할로비움 아라바티쿰(Acetohalobium arabaticum), 암모니펙스 데겐시(Ammonifex degensii), 칼디셀룰로시럽토르 벡시(Caldicelulosiruptor becscii), 칸디다투스 데술포루디스(Candidatus Desulforudis), 클로스트리디움 보툴리눔(Clostridium botulinum), 클로스트리디움 디피실레(Clostridium difjicile), 피네골디아 마그나(Finegoldia magna), 나트라나에어로비우스 써모필루스(Natranaerobius thermophilus), 펠로토마쿨룸 써모프로피오니쿰(Pelotomaculum thermopropionicum), 액시디티오바실러스 칼두스(Acidithiobacillus caldus), 액시디티오바실러스 페로옥시단스(Acidithiobacillus ferrooxidans), 알로크로마티움 비노섬(Allochromatium vinosum), 마리노박터 종(Marinobacter sp.), 니트로소코쿠스 할로필루스(Nitrosococcus halophilus), 니트로소코쿠스 와트소니(Nitrosococcus watsoni), 슈도알테로모나스 할로플랑크티스(Pseudoalteromonas haloplanktis), 크테도노박터 라세미페르(Ktedonobacter racemifer), 메타노할로비움 에베스티가툼(Methanohalobium evestigatum), 아나바에나 바리아빌리스(Anabaena variabilis), 노둘라리아 스푸미게나(Nodularia spumigena), 노스톡 종(Nostoc sp.), 아르트로스피라 막시마(Arthrospira maxima), 아르트로스피라 플라텐시스(Arthrospira platensis), 아르트로스피라 종(Arthrospira sp.), 링비아 종(Lyngbya sp.), 마이크로콜레우스 크토노플라스테스(Microcoleus chthonoplastes), 오실라토리아 종(Oscillatoria sp.), 페트로토가 모빌리스(Petrotoga mobilis), 써모시포 아프리카누스(Thermosipho africanus), 아카리오클로리스 마리나(Acaryocloris marina) 또는 알려진 PAM 서열을 갖는 CRISPR 뉴클레아제를 코딩하는 종으로부터 유래될 수 있다. 배양되지 않은 박테리아에 의해 코딩된 CRISPR 뉴클레아제도 본 발명의 맥락에서 사용될 수 있다. (Burstein et al. Nature, 2017 참조). 공지된 PAM 서열을 갖는 CRISPR 단백질의 변이체, 예를 들어 SpCas9 D1135E 변이체, SpCas9 VQR 변이체, SpCas9 EQR 변이체 또는 SpCas9 VRER 변이체가 또한 본 발명의 맥락에서 사용될 수 있다.
따라서, CRISPR 시스템의 RNA 가이드 DNA 뉴클레아제, 예를 들면, Cas9 단백질 또는 변형된 Cas9 또는 Cas9의 상동체 또는 오르토로그(ortholog), 또는 기타 타입의 CRISPR 시스템에 속하는 기타 RNA 가이드 DNA 뉴클레아제, 예를 들면, Cpf1 및 그의 상동체 및 오르토로그가 본 발명의 조성물에서 사용될 수 있다. 추가적인 CRISPR 뉴클레아제, 예를 들어, 참조에 의해 본원에 포함된, PCT 국제 출원 공개 WO2020/223514 및 WO2020/223553에 기재된 뉴클레아제도 사용될 수 있다.
특정 구체예에서, CRISPR 뉴클레아제는 천연 Cas 단백질의 "기능적 유도체"일 수 있다. 원형(native) 서열 폴리펩티드의 "기능적 유도체"는 원형 서열 폴리펩티드와 공통인 정성적 생물학적 특성을 갖는 화합물이다. "기능적 유도체"는 원형 서열의 단편, 원형 서열 폴리펩티드의 유도체 및 그의 단편을 포함하나, 이에 한정되지 않으나, 단, 이들은 상응하는 원형 서열 폴리펩티드와 공통적인 생물학적 활성을 갖는다. 본원에서 고려되는 생물학적 활성은 DNA 기질을 단편으로 가수분해하는 기능적 유도체의 능력이다. 용어 "유도체(derivative)"는 폴리펩티드의 아미노산 서열 변이체, 공유결합성 변형(covalent modification) 및 그의 융합체를 모두 포함한다. Cas 폴리펩티드 또는 그의 단편의 적합한 유도체는 Cas 단백질 또는 그의 단편의 돌연변이체, 융합체, 공유결합성 변형을 포함하나, 이에 한정되지 않는다. 유도체는 CRISPR 닉카아제(nickase), 촉매적으로 불활성이거나 "데드(dead)" CRISPR 뉴클레아제, 및 CRISPR 뉴클레아제 또는 그의 유도체와 염기 에디터(base editor) 또는 레트로트랜스포존(retrotransposon)과 같은 기타 효소의 융합체를 포함하나, 이에 한정되지 않는다. 예를 들어, Anzalone et al. (2019) 및 PCT 국제출원 PCT/US2020/037560을 참조한다.
Cas 단백질 또는 그의 단편, 및 Cas 단백질의 유도체 또는 그의 단편을 포함한, Cas 단백질은 세포로부터 수득될 수 있거나, 화학적으로 합성되거나, 이 두 절차의 조합에 의해 합성될 수 있다. 세포는 자연적으로 Cas 단백질을 생산하는 세포일 수 있거나 자연적으로 Cas 단백질을 생산하고 더 높은 발현 수준으로 내인성 Cas 단백질을 생산하거나, 내인성 Cas와 동일하거나 또는 다른 Cas를 코딩하는 것인 외인성으로 도입된 핵산으로부터 Cas 단백질을 생산하도록 유전적으로 조작된 세포일 수 있다. 일부 경우에, 세포는 자연적으로 Cas 단백질을 생성하지 않고, Cas 단백질을 생성하도록 유전적으로 조작된다.
일부 구체예에서, CRISPR 뉴클레아제는 Cpf1이다. Cpf1은 T가 풍부한 프로토스페이서 인접 모티프를 이용하는 단일 RNA 가이드 엔도뉴클레아제이다. Cpf1은 점착성(staggered) DNA 이중가닥 절단을 통해 DNA를 절단한다. 액시드아미노코커스(Acidaminococcus)와 라크노스피라세애(Lachnospiraceae)의 두 Cpf1 효소는 인간 세포에서 효율적인 게놈 편집 활성을 보이는 것으로 확인되었다. (Zetsche et al., 2015 참조).
따라서, 타입 II CRISPR 시스템의 RNA 가이드 DNA 뉴클레아제, 예를 들면, Cas9 단백질 또는 변형된 Cas9 또는 Cas9의 상동체, 오르토로그 또는 변이체, 또는 기타 타입의 CRISPR 시스템에 속하는 기타 RNA 가이드 DNA 뉴클레아제, 예를 들면, Cpf1, 그의 상동체, 오르토로그, 또는 변이체가 본 발명에서 사용될 수 있다.
일부 구체예에서, 가이드 분자는 새롭거나 개선된 특성(예를 들어, 분해로부터의 개선된 안정성, 개선된 혼성화 에너지, 또는 RNA 가이드 DNA 뉴클레아제와의 개선된 결합 특성)을 부여하는 하나 이상의 화학적 변형을 포함한다. 적합한 화학적 변형은 변형된 염기, 변형된 당 모이어티, 또는 변형된 뉴클레오시드간 결합(inter-nucleoside linkage)을 포함하나, 이에 한정되지 않는다. 적합한 화학적 변형의 비한정적 예는: 4-아세틸시티딘, 5-(카르복시히드록시메틸)우리딘, 2'-O-메틸시티딘, 5-카르복시메틸아미노메틸-2-티오우리딘, 5-카르복시메틸아미노메틸우리딘, 디히드로우리딘, 2'-O-메틸슈도우리딘, "베타, D-갈락토실퀘오신(beta, D-galactoqueuosin)", 2'-O-메틸구아노신, 이노신, N6-이소펜테닐아데노신, 1-메틸아데노신, 1-메틸슈도우리딘, 1-메틸구아노신, 1-메틸이노신, "2,2-디메틸구아노신", 2-메틸아데노신, 2-메틸구아노신, 3-메틸시티딘, 5-메틸시티딘, N6-메틸아데노신, 7-메틸구아노신, 5-메틸아미노메틸우리딘, 5-메톡시아미노메틸-2-티오우리딘, "베타, D-만노실퀘오신", 5-메톡시카르보닐메틸-2-티오우리딘, 5-메톡시카르보닐메틸우리딘, 5-메톡시우리딘, 2-메틸티오-N6-이소펜테닐아데노신, N-((9-베타-D-리보푸라노실-2-메틸티오퓨린-6-일)카르바모일)트레오닌, N-((9-베타-D-리보푸라노실퓨린-6-일)N-메틸카르바모일)트레오닌, 우리딘-5-옥시아세트산-메틸에스테르, 우리딘-5-옥시아세트산, 와이부톡소신(wybutoxosine), 퀘오신(queuosin), 2-티오시티딘, 5-메틸-2-티오우리딘, 2-티오우리딘, 4-티오우리딘, 5-메틸우리딘, N-((9-베타-D-리보푸라노실퓨린-6-일)-카르바모일)트레오닌, 2'-O-메틸-5-메틸우리딘, 2'-O-메틸우리딘, 와이부토신(wybutosine), "3-(3-아미노-3-카르복시-프로필)우리딘, (acp3)u", 2'-0-메틸(M), 3'-포스포로티오에이트(MS), 3'-티오PACE(MSP), 슈도우리딘 또는 1-메틸 슈도-우리딘을 포함한다. 각각의 가능성은 본 발명의 별개의 구체예를 나타낸다.
RNA-가이드 CRISPR 뉴클레아제에 의해 LDLR 대립유전자를 표적화하는 것 외에도, 표적 세포에서 LDLR 발현을 억제하는 기타 수단은 갭머(gapmer), shRNA, siRNA, 맞춤형 TALEN, 메가뉴클레아제 또는 ZFN(zinc finger nuclease), 소분자 억제제, 및 표적 세포에서 유전자의 발현을 감소시키거나 제거하기 위한 당업계에 공지된 임의의 다른 방법을 포함하나, 그에 한정되지 않는다. 예를 들어, 각각 전체 내용이 참조에 의해 본원에 포함된, 미국 특허번호 6,506,559; 7,560,438; 8,420,391; 8,552,171; 7,056,704; 7,078,196; 8,362,231; 8,372,968; 9,045,754; 및 PCT 국제 공개 번호 WO/2004/067736; WO/2006/097853; WO/2003/087341; WO/2000/041566l; WO/2003/080809; WO/2010/079430; WO/2010/079430; WO/2011/072246; WO/2018/057989; 및 WO/2017/164230를 참조한다.
유리하게는, 본원에 제시된 가이드 RNA 분자는 다른 가이드 RNA 분자에 비해 세포에서 CRISPR 뉴클레아제와 복합체화될 때 향상된 효율을 제공한다. 이러한 특별히 설계된 서열은 또한 다른 뉴클레오티드 표적화 기반 유전자 편집 또는 유전자 침묵화 방법, 예를 들어 siRNA, TALEN, 메가뉴클레아제 또는 징크핑거 뉴클레아제를 위해 LDLR 표적 부위를 식별하는 데 유용할 수 있다.
세포로의 전달
본원에 기술된 조성물 중 어느 하나는 임의의 적합한 수단에 의해 표적 세포에 전달될 수 있다. 본 발명의 RNA 분자 조성물은 포유동물 간 세포, 간세포 또는 줄기 세포와 같은 LDLR 대립유전자를 포함하고 및/또는 발현하는 임의의 세포를 표적화할 수 있다. 예를 들어, 일 구체예에서, RNA 분자는 표적 세포에서 LDLR 대립유전자를 특이적으로 표적화하고 표적 세포는 간 세포, 간세포 또는 줄기 세포이다. 세포로의 전달은 생체내, 생체외 또는 시험관내에서 수행될 수 있다. 전달은 렌티바이러스, 아데노-관련 바이러스(AAV) 또는 나노입자에 패키징된 조성물을 개체의 간 또는 개체의 간 세포에 생체내 전달하는 것일 수 있다. 전달은 개체의 세포, 예를 들어, 개체로부터 분리된 간 세포, 헤파토사이드 또는 줄기 세포로 체외에서 이루어질 수 있다. 또한, 본원에 기술된 핵산 조성물은 DNA 분자, RNA 분자, 리보핵단백질(RNP), 핵산 벡터, 또는 이들의 임의의 조합 중 하나 이상으로서 세포에 전달될 수 있다.
일부 구체예에서, 본원에 기술된 조성물의 생체내 전달 방법은 렌티바이러스, 아데노-관련 바이러스(AAV), 또는 나노입자에 의한 전달을 포함한다. 일부 구체예에서, 본원에 기술된 조성물의 생체내 전달 방법은 렌티바이러스, 아데노-관련 바이러스(AAV), 네이키드(naked) RNA, 또는 나노입자, 예를 들면, 지질 나노입자에 의한 전달을 포함한다. 상기 조성물은 RNA 조성물의 형태일 수 있다. 상기 조성물은 리보핵단백질(RNP) 조성물의 형태일 수 있다. 따라서, 전달은 개체, 예를 들어 고콜레스테롤혈증을 앓고 있는 개체 내의 간 세포로 생체내에서 수행될 수 있다.
일부 구체예에서, 본원에 기재된 조성물 중 어느 하나는 생체외에서 세포에 전달된다. 일부 구체예에서, 상기 세포는 줄기 세포이다. 일부 구체예에서, 상기 세포는 간 세포이다. 일부 구체예에서, 상기 세포는 헤파토사이트(hepatocyte)이다. 일부 구체예에서, 상기 세포는 iPS 유래 헤파토사이트이다. 상기 조성물은 전기천공, 바이러스 형질도입, 나노입자 전달, 리포좀 등을 포함하나, 이에 한정되지 않는 임의의 공지된 생체외 전달 방법에 의해 세포에 전달될 수 있다. 상기 조성물은 RNP 조성물의 형태일 수 있다. 추가적인 상세한 전달 방법이 이 섹션 전반에 걸쳐 설명된다.
일부 구체예에서, 선택적으로 간엽(liver lobe) 또는 헤파토사이트 세포는 예를 들어 생검을 수행하여 개체로부터 수득된다. 그 후, 수득된 세포는 본원에 기술된 조성물의 생체외 전달에 의해 유전적으로 변형될 수 있다. 변형된 세포는 엽 이식(lobe transplantation) 또는 헤파토사이트 이식을 수행함으로써 개체에게 재도입될 수 있다.
일부 구체예에서, RNA 분자는 화학적 변형을 포함한다. 적합한 화학적 변형의 비한정적 예는 2'-O-메틸(M), 2'-O-메틸, 3'포스포로티오에이트(MS) 또는 2'-O-메틸, 3'티오PACE(MSP), 슈도우리딘, 및 1-메틸 슈도-우리딘을 포함한다. 각각의 가능성은 본 발명의 별도의 실시예를 나타낸다.
임의의 적합한 바이러스 벡터 시스템이 핵산 조성물, 예를 들면, 본 발명의 RNA 조성물을 전달하는 데 사용될 수 있다. 통상적인 바이러스 및 비-바이러스 기반 유전자 전달 방법이 핵산을 도입하고 조직을 표적화하기 위해 사용될 수 있다. 특정한 구체예에서, 핵산은 생체내(in vivo) 또는 생체외(ex vivo) 유전자 치료법 용도를 위해 투여된다. 비-바이러스 벡터 전달 시스템은 네이키드(naked) 핵산, 및 리포좀 또는 폴록사머와 같은 전달 비히클과 복합체화된 핵산을 포함한다. 유전자 치료법 절차에 대한 검토를 위해, Anderson (1992); Nabel & Felgner (1993); Mitani & Caskey (1993); Dillon (1993); Miller (1992); Van Brunt (1988); Vigne (1995); Kremer & Perricaudet (1995); Haddada et al. (1995); 및 Yu et al., (1994)을 참조한다.
핵산 및/또는 단백질의 비-바이러스 전달의 방법은 전기천공, 리포펙션, 미세주사, 바이올리스틱(biolistic), 입자 총 가속화, 비로좀(virosome), 리포좀, 면역리포좀, 지질 나노입자(LNP), 다중양이온 또는 지질:핵산 접합체, 인공 비리온, 및 핵산의 작용체-증강 흡수(agent-enhanced uptake)를 포함하거나, 박테리아 또는 바이러스(예를 들어, 아그로박테리움(Agrobacterium), 리조비움 종 NGR234(Rhizobium sp. NGR234), 시노리조보이움 멜릴로티(Sinorhizoboium meliloti), 메조리조비움 로티(Mesorhizobium loti), 담배 모자이크 바이러스(TMV), 감자 바이러스 X, 콜리플라워 모자이크 바이러스(cauliflower mosaic virus) 및 카싸바 베인 모자이크 바이러스(cassava vein mosaic virus)에 의해 식물 세포로 전달될 수 있다. (예를 들어, Chung et al. (2006)을 참조한다). 예를 들어, Sonitron 2000 시스템(Rich-Mar)을 사용한 초음파천공(sonoporation)이 또한 핵산의 전달에 사용될 수 있다. 단백질 및/또는 핵산의 양이온성-지질 매개 전달이 또한 생체내, 생체외, 또는 시험관내 전달 방법으로서 고려된다. (Zuris et al. (2015);, Coelho et al. (2013); Judge et al. (2006); 및 Basha et al. (2011)을 참조한다).
비-바이러스 벡터, 예를 들면, 트랜스포존-기반 시스템(transposon-based system), 예를 들어 재조합 Sleeping Beauty 트랜스포존 시스템 또는 재조합 PiggyBac 트랜스포존 시스템이 또한 표적 세포로 전달될 수 있고, 표적 세포에서 조성물의 분자의 폴리뉴클레오티드 서열 또는 조성물의 분자를 코딩하는 폴리뉴클레오티드 서열의 전위(transposition)에 이용될 수 있다.
추가적인 예시적 핵산 전달 시스템은 Amaxa RTM. Biosystems(독일 쾰른 소재), Maxcyte, Inc.(미국 메릴랜드주 록빌 소재), BTX Molecular Delivery Systems(미국 매사추세츠주 홀리스턴 소재) 및 Copernicus Therapeutics Inc.,(예를 들어, 미국 특허 제6,008,336호 참조)에 의해 제공되는 것을 포함한다. 리포펙션은, 예를 들어 미국 특허 제5,049,386호, 미국 특허 제4,946,787호; 및 미국 특허 제4,897,355호에 기재되어 있으며, 리포펙션 시약은 상업적으로 판매된다(예를 들어, Transfectam.TM., Lipofectin.TM. 및 Lipofectamine.TM. RNAiMAX). 폴리뉴클레오티드의 효율적인 수용체-인식 리포펙션에 적합한 양이온성 및 중성 지질은 PCT 국제 공개 WO/1991/017424 및 WO/1991/016024에 개시된 것들을 포함한다. 전달은 세포(생체외 투여) 또는 표적 조직(생체내 투여)에 대한 것일 수 있다.
면역지질 복합체와 같은 표적화된 리포좀을 포함한, 지질:핵산 복합체의 제조는 통상의 기술자에게 잘 알려져 있다(예를 들어, Crystal, Science (1995); Blaese et al., (1995); Behr et al., (1994); Remy et al., (1994); Gao 및 Huang (1995); Ahmad 및 Allen(1992); 미국 특허번호 4,186,183; 4,217,344; 4,235,871; 4,261,975; 4,485,054; 4,501,728; 4,774,085; 4,837,028; 및 4,946,787을 참조한다).
추가적인 전달 방법은 전달될 핵산을 EnGeneIC 전달 비히클(EDV) 내로 패키징하는 것의 사용을 포함한다. 이들 EDV는 이중특이적 항체를 사용하여 표적 조직으로 특이적으로 전달되며, 상기 항체의 하나의 암(arm)은 표적 조직에 대한 특이성을 갖고, 나머지 암은 EDV에 대한 특이성을 갖는다. 상기 항체가 EDV를 표적 세포 표면으로 가져간 다음, EDV가 엔도시토시스(endocytosis)에 의해 세포 내로 들어간다. 일단 세포 안에 들어가면, 내용물이 방출된다(MacDiamid et al., 2009 참조).
핵산의 바이러스 매개 전달을 위한 RNA 또는 DNA 바이러스 기반 시스템의 사용은 신체의 특정 세포에 바이러스를 표적화하고 바이러스 페이로드(viral payload)를 핵으로 수송하기 위한 고도로 진화된 프로세스를 이용한다. 바이러스 벡터는 환자에게 직접 투여될 수 있거나(생체내) 시험관내에서 세포를 치료하는 데 사용될 수 있고 변형된 세포가 환자에게 투여된다(생체외). 통상적인 핵산의 전달을 바이러스 기반 시스템은 유전자 전달을 위한 재조합 레트로바이러스, 렌티바이러스, 아데노바이러스, 아데노-관련 바이러스, 백시니아 바이러스 및 단순 포진 바이러스(herspes simplex virus) 벡터를 포함하나 이에 한정되지 않는다.
레트로바이러스의 친화성(tropism)은 외래 외피 단백질을 통합하여 표적 세포의 잠재적인 표적 집단을 확장함으로써 변경될 수 있다. 렌티바이러스 벡터는 비-분열(non-dividing) 세포를 형질도입하거나 감염시킬 수 있고 일반적으로 높은 바이러스 역가를 생성할 수 있는 레트로바이러스 벡터이다. 레트로바이러스 유전자 전달 시스템의 선택은 표적 조직에 따라 다르다. 레트로바이러스 벡터는 최대 6-10 kb의 외래 서열의 패키징 능력을 갖는 시스-작용 긴 말단 반복(long terminal repeat: LTR)으로 구성된다. 최소 시스-작용 LTR이 벡터의 복제 및 패키징에 충분하며, 이는 영구적인 이식 유전자(transgene) 발현을 제공하기 위해 치료 유전자를 표적 세포에 통합시키는데 사용된다. 널리 사용되는 레트로바이러스 벡터는 MuLv(murine leukemia virus), GaLV(gibbon ape leukemia virus), SIV(Simian Immunodeficiency virus), HIV(Human Immunodeficiency virus), 및 이들의 조합에 기반한 것들을 포함한다(예를 들어, Buchschacher et al.( 1992), Johann 등(1992), Sommerfelt 등(1990), Wilson 등(1989), Miller 등(1991), PCT 국제 공개 번호. WO/1994/026877A1 참조).
적어도 6개의 바이러스 벡터 접근법이 현재 임상 시험에서 유전자 전달을 위해 이용 가능하며, 이는 형질도입체(transducing agent)를 생성하기 위해 헬퍼 세포주 내로 삽입된 유전자에 의한 결함 벡터(defective vector)의 보완을 포함하는 접근법을 이용한다.
pLASN 및 MFG-S는 임상 시험에서 사용된 레트로바이러스 벡터의 예이다(Dunbar et al., 1995; Kohn et al., 1995; Malech et al., 1997 참조). PA317/pLASN은 유전자 치료법 시험에서 사용된 최초의 치료용 벡터이었다(Blaese et al., 1995). 50% 이상의 형질도입 효율이 MFG-S 패키징된 벡터에서 관찰되었다. (Ellem 등, (1997); Dranoff 등, 1997).
패키징 세포는 숙주 세포를 감염시킬 수 있는 바이러스 입자를 형성하는 데 사용된다. 이러한 세포는 아데노바이러스, AAV를 패키징하는 293 세포, 및 레트로바이러스를 패키징하는 Psi.2 세포 또는 PA317 세포를 포함한다. 유전자 치료법에서 사용되는 바이러스 벡터는 일반적으로 바이러스 입자 내로 핵산 벡터를 패키징하는 생산체 세포주(producer cell line)에 의해 생성된다. 벡터는 전형적으로 패키징 및 숙주 내로의 후속 통합(적용 가능한 경우)을 위해 요구되는 최소 바이러스 서열을 포함하며, 다른 바이러스 서열은 발현될 단백질을 코딩하는 발현 카세트에 의해 대체된다. 결여된(missing) 바이러스 기능은 패키징 세포주에 의해 트랜스로 공급된다. 예를 들어, 유전자 치료법에서 사용되는 AAV 벡터는 전형적으로 패키징 및 숙주 게놈 내로의 통합을 위해 요구되는 AAV 게놈으로부터의 ITR(inverted terminal repeat) 서열만을 보유한다. 바이러스 DNA는 세포주에서 패키징되며, 이는 나머지 AAV 유전자, 즉 rep 및 cap을 코딩하나, ITR 서열은 없는 헬퍼 플라스미드를 포함한다. 상기 세포주는 또한 헬퍼로서 아데노바이러스로 감염된다. 헬퍼 바이러스는 AAV 벡터의 복제 및 헬퍼 플라스미드로부터 AAV 유전자의 발현을 촉진시킨다. 헬퍼 플라스미드는 ITR 서열의 부재로 인해 유의한 양으로 패키징되지 않는다. 아데노바이러스에 의한 오염은, 예를 들어 아데노바이러스가 AAV보다 더 민감한 열 처리에 의해 감소될 수 있다. 추가적으로, AAV는 바큘로바이러스(baculovirus) 시스템을 사용하여 임상 규모로 생산될 수 있다(미국 특허 번호 제7,479,554호 참조).
여러 유전자 치료법 적용에서, 유전자 치료법 벡터는 특정 조직 유형으로 고도의 특이성으로 전달되는 것이 바람직하다. 따라서, 바이러스 벡터는 리간드를 바이러스의 외부 표면 상의 바이러스 코트(viral coat) 단백질과의 융합 단백질로서 발현시킴으로써 주어진 세포 유형에 대해 특이성을 갖도록 변형될 수 있다. 리간드는 목적 세포 유형의 세포 상에 존재하는 것으로 알려진 수용체에 대해 친화도를 갖도록 선택된다. 예를 들어, Han et al. (1995)은 MMLV(Molony murine leukemia virus)가 gp70에 융합된 인간 헤레귤린(heregulin)을 발현하도록 변형될 수 있고, 재조합 바이러스가 인간 상피 성장 인자 수용체를 발현하는 특정 인간 유방암 세포를 감염시킨다는 것을 보고하였다. 이 원리는 다른 바이러스-표적 세포 쌍으로 확장될 수 있고, 여기서 표적 세포는 수용체를 발현하고 바이러스는 세포-표면 수용체에 대한 리간드를 포함하는 융합 단백질을 발현한다. 예를 들어, 사상 파아지(filametous phage)는 실질적으로 임의의 선택된 세포 수용체에 대해 특이적 결합 친화도를 갖는 항체 단편(예를 들어, FAB 또는 Fv)을 표시하도록 조작될 수 있다. 전술된 내용은 주로 바이러스 벡터에 적용되지만, 동일한 원리가 비-바이러스 벡터에 적용될 수 있다. 이러한 벡터는 특정 표적 세포에 의한 흡수에 유리한 특정 흡수 서열을 포함하도록 조작될 수 있다.
유전자 치료법 벡터는 예를 들면, 전신 투여(예를 들어, 유리체내, 정맥내, 복강내, 근육내, 진피하, 또는 두개내 주입) 또는 국소 적용에 의해, 개별 환자로의 투여에 의해 생체내 전달될 수 있다.
대안적으로, 벡터는 개별 환자로부터 외식된 세포(예를 들어, 림프구, 골수 흡입물, 조직 생검)와 같은 생체외 세포 또는 범용 공여체 조혈 줄기 세포(universal donor hematopoietic stem cell)로 전달될 수 있고, 선택적으로, 벡터를 내포하는 세포에 대한 선택 후에, 환자 내로의 세포의 재이식이 이어질 수 있다. 벡터가 포함된 세포를 선택합니다. 비한정적인 예시적 생체외 접근법은 배양을 위해 환자로부터 조직(예: 말초 혈액, 골수 및 비장)의 채취, 배양된 세포(예: 조혈 줄기 세포)로의 핵산 전달, 및 뒤이은 환자의 표적 조직(예: 골수, 비장)으로의 세포의 이식을 포함할 수 있다. 일부 구체예에서, 줄기 세포 또는 조혈 줄기 세포는 생존력 증강제(viability enhancer)로 추가로 처리될 수 있다.
진단, 연구, 또는 유전자 치료법(예를 들어, 숙주 유기체 내로의 형질감염된 세포의 재주입을 통한 유전자 치료법)을 위한 생체외 세포 형질감염은 통상의 기술자에게 잘 알려져 있다. 바람직한 구체예에서, 세포를 대상 유기체로부터 단리하고, 핵산 조성물로 형질감염시키고, 대상 유기체(예를 들어, 환자) 내로 다시 재주입한다. 생체외 형질감염에 적합한 다양한 세포 유형은 통상의 기술자에게 잘 알려져 있다(예를 들어, 환자로부터 세포를 단리하고 배양하는 방법의 논의에 대해, Freshney, "Culture of Animal Cells, A Manual of Basic Technique and Specialized Applications (6th edition, 2010) 및 그에 인용된 참조문헌 참조).
치료용 핵산 조성물을 포함하는 벡터(예를 들어, 레트로바이러스, 리포좀 등)가 또한 생체내에서 세포의 형질도입을 위해 유기체에 직접 투여될 수 있다. 투여는 주사, 주입, 국소 적용(예: 점안액 및 크림) 및 전기천공을 포함하나, 이에 한정되지 않는, 분자를 혈액 또는 조직 세포와의 궁극적 접촉으로 도입하기 위해 일반적으로 사용되는 임의의 경로에 의한다. 이러한 핵산을 투여하는 적합한 방법이 이용 가능하고 통상의 기술자에게 잘 알려져 있으며, 하나 초과의 경로가 특정 조성물을 투여하는 데 이용될 수 있지만, 특정 경로가 종종 또 다른 경로보다 더 즉각적이고 더 효과적인 반응을 제공할 수 있다. 일부 구체예에 따르면, 조성물은 IV 주사를 통해 전달된다.
면역 세포(예를 들어, T-세포) 내로의 이식유전자의 도입에 적합한 벡터는 비-통합 렌티바이러스(non-integrating lentivirus) 벡터를 포함한다. 예를 들어, 미국 특허 공개 제2009/0117617호를 참조한다.
약학적으로 허용 가능한 담체는 부분적으로, 투여되는 특정 조성물 및 조성물을 투여하는 데 사용되는 특정 방법에 의해 결정된다. 따라서, 하기에 기재된 바와 같이, 약학적 조성물의 매우 다양한 적합한 제형이 이용 가능하다(예를 들어, Remington's Pharmaceutical Sciences, 17th ed., 1989 참조).
LDLR 유전자의 대립유전자를 특이적으로 표적화하는 RNA 가이드 서열의 예
다수의 가이드 서열이 LDLR 유전자를 표적화하도록 설계될 수 있으나, 하기 표 1에 기재되고, 서열번호 1 내지 10736으로 식별되는 뉴클레오티드 서열이 구체적으로, 본원에 기재된 방법을 효과적으로 구현하기 위해 선택되었다.
표 1은 LDLR 대립유전자와 회합하여 전술된 구체예에 기재된 바와 같이 사용하기 위해 설계된 가이드 서열을 보여준다. 각각의 조작된(engineered) 가이드 분자는 또한 PAM(protospacer adjacent motif), 예를 들어, "N"는 임의의 핵염기인 것인 서열 NGG 또는 NAG와 일치하는 PAM 옆에 있는 목적 표적 게놈 DNA 서열과 회합하도록 설계된다. 가이드 서열은, 예를 들어 SpCas9WT(PAM SEQ: NGG), SpCas9.VQR.1(PAM SEQ: NGAN), SpCas9.VQR.2(PAM SEQ: NGNG), SpCas9.EQR(PAM SEQ: NGAG), SpCas9.VRER(PAM SEQ: NGCG), SaCas9WT(PAM SEQ: NNGRRT), SpRY(PAM SEQ: NRN 또는 NYN), NmCas9WT(PAM SEQ: NNNNGATT), Cpf1(PAM SEQ: TTTV) 또는 JeCas9WT(PAM SEQ: NNNVRYM)를 포함하나, 이에 한정되지 않는 하나 이상의 상이한 CRISPR 뉴클레아제와 함께 작동하도록 설계되었다. 본 발명의 RNA 분자는 각각 하나 이상의 상이한 CRISPR 뉴클레아제와 함께 복합체를 형성하도록 설계되었고, 이용된 CRISPR 뉴클레아제 각각에 대해 하나 이상의 상이한 PAM 서열을 이용하여 목적 폴리뉴클레오티드 서열을 표적화하도록 설계되었다.
표 1: 특정한 LDLR 유전자 표적과 회합하도록 설계된 가이드 서열
| 표적 | 20 염기 가이드의 서열번호 | 21 염기 가이드의 서열번호 | 22 염기 가이드의 서열번호 |
| 정지 코돈으로부터 30 nt 및 폴리아데닐화 부위로부터 상류 30 nt를 포함한 19:11131280-19:11133820 LDLR 3'UTR, |
1-3564 | 3565-7118 | 7119-10735 |
표 1의 컬럼 1에 열거된 표시된 위치는 gnomAD v3 데이터베이스 및 UCSC Genome Browser 어셈블리 ID: hg38, 시퀀싱/어셈블리 공급자 ID: Genome Reference Consortium Human GRCh38.p12(GCA_000001405.27)에 근거한다. 어셈블리 일자: 2013년 12월 initial release; 2017년 12월 patch release 12.
본 발명의 보다 완전한 이해를 촉진하기 위해 실시예가 하기에 제공된다. 하기 실시예는 본 발명의 제조 및 실시의 예시적 방식을 예시한다. 그러나, 본 발명의 범주는 이들 실시예에 개시된 특정 구체예에 제한되지 않으며, 이는 단지 예시 목적을 위한 것이다.
도 1a-1h: LDLR 3'UTR 절제의 기능적 개념 증명. LDLR 유전자의 3' UTR을 SpCas9와 두 개의 단일 가이드 RNA(sgRNA)를 동시에 사용하여 변형시켰다. 이 표적화는 HepG2 세포에서 수행되었고, 거의 전체 3' UTR 영역(g1 + g9), miR85 결합 영역(g6 + g7), 또는 이전에 FH 환자에서 LDLR 발현을 상향 조절하는 것으로 확인된 2.5 킬로베이스 영역 삭제를 절제했다(도 1a). 절제된 모든 세포는 mRNA(qRT-PCR "Rq" 값으로 측정, 도 1b), 총 단백질 존재도(abundance)(웨스턴 블롯으로 측정, 도 1c), 및 막 단백질 존재도(유세포 측정 분석(flow cytometry analysis)으로 측정, 도 1d)의 상향 조절을 보였다. 효과는 전체 3' UTR을 절제한 세포에서 특히 뚜렷했다. 가이드 g1 + g9에 의해 3' UTR을 절제한 세포에서 형광-LDL 콜레스테롤 흡수를 표시된 시점에 유동 세포 측정법으로 측정했다. 모든 시점에서 콜레스테롤 흡수가 최대 2배까지 상향 조절되는 것으로 나타났다(LDL-DyLight™ 488 - 콜레스테롤 흡수, 도 1e). 다양한 쌍의 sgRNA를 사용하여 독립적인 3'UTR LDLR 절제 실험을 수행했다(도 1f 및 도 1g). LDLR 발현(Rq 값)에 대한 sgRNA 쌍의 효과를 포함하여, 도 1f 및 도 1g에 표시된 LDLR 3'UTR 절제 실험의 절단 맵(cleavage map)이 도 1h에 도시된다. ddPCR 프로브 부위를 포함하지 않는 쌍은 ddPCR로 감지할 수 없다.
도 2a-2d: 환자로부터의 이형접합성 LDLR-돌연변이 LCL 세포: 두 환자 모두에서 표면 수용체의 수준 감소가 확인되었다. 돌연변이 환자 LCL 세포주 대 WT 세포에서 막 LDLR의 유세포 측정 분석 (도 2a). % 발현은 WT LCL 세포에 대한 해당 값 중 각 세포주의 기하 평균의 백분율로 계산되었다 (도 2b). GM1488 돌연변이를 갖는 FH 환자 LCL 세포는 Gly197 [ΔG197]의 결실에 해당했고 (도 2c), 및 GM1460 돌연변이를 갖는 FH 환자 LCL 세포는 코돈 646에서 시스테인의 티로신으로의 치환[C646Y]에 해당했다 (도 2d).
도 3a-3d: 이형접합성 FH 환자 LCL 세포에서 LDLR 3' UTR의 절제는 표면 LDLR의 상향조절 및 콜레스테롤 흡수의 증가를 가져온다. LDLR 유전자의 3' UTR은 이형접합성 FH 환자 유래 LCL 세포주에서 특정 가이드(g1 및 g9) 및 SpCas9를 사용하여 절제되었다. 절제 후, 세포를 LDLR 발현 수준 및 LDL-콜레스테롤 흡수에 대해 분석하였다. 도 3a. ddPCR로 측정한 LDLR 3' UTR의 절제 비율. 도 3b. qRT-PCR로 측정한 LDLR의 mRNA 수준. 도 3c. 특정 항체를 사용하여 유동 세포 측정법으로 측정한 LDLR 표면 단백질 발현 수준. 도 3d. 4시간 인큐베이션 후 유동 세포 측정법으로 측정한 LDL-Dylight-488-콜레스테롤의 흡수.
도 4a-4c: 마우스 간세포주 Hepa1-6에서 LDLR의 3' UTR 절제는 인간 간 HepG2 세포에 적합한(compatible) 결과를 보여준다. LDLR 유전자의 3' UTR은 마우스 간암 세포주 Hepa1-6에서 특정 가이드(g1m 및 g6m) 및 SpCas9를 사용하여 절제되었다. 절제 후, 세포를 LDLR 발현 수준 및 LDL-콜레스테롤 흡수에 대해 분석하였다. 도 4a. qRT-PCR로 측정한 LDLR의 mRNA 수준. 도 4b. 특정 항체를 사용하여 유동 세포 측정법으로 측정한 LDLR 표면 단백질 발현 수준. 도 4c. 4시간 인큐베이션 후 유동 세포 측정법으로 측정한 LDL-Dylight-488-콜레스테롤의 흡수.
도 5a-5c: 3'UTR 영역의 LDLR OMNI -79 CRISPR 뉴클레아제 기반 가이드 스크린. 도 5a. HeLa 세포에서 WT OMNI-79 또는 OMNI-79 V5570을 사용한, LDLR의 표시된 영역 3' UTR을 표적으로 하는 가이드의 형질감염 기반 가이드 스크린. 수개의 가이드는 높은 수준의 편집을 보였고, RNP 또는 RNA 조성물로서 추가로 평가된다. 도 5b. HeLa 세포에서, OMNI-103을 사용한, LDLR의 표시된 영역 3' UTR을 표적으로 하는 가이드의 형질감염 기반 가이드 스크린. OMNI-103 CRISPR 뉴클레아제를 사용하는 복수의 가이드 분자의 높은 활성. 도 5c. 가이드 분자 LDLR 표적 부위의 도식(schematic).
도 6a-6e: CRISPR 기반 편집에 의한 PCSK9의 녹아웃 및 HepG2 세포에서 LDLR 발현 및 LDL 흡수에 대한 효과. 도 6a. PCSK9 편집 - HepG2 세포의 편집 수준은 특정 가이드 분자에 의한 PCSK9의 변형 후에 측정되었다. 도 6b. PCSK9 qRT-PCR - PCSK9 편집 후 HepG2 세포에서 PCSK9의 mRNA 수준. 도 6c. 분비된 PCSK9 - WT HepG2 세포와 비교하여 PCSK9-편집 세포에서 PCSK9의 분비를 ELISA로 측정했다. 도 6d. LDLR 발현 - LDLR의 막 발현은 야생형 및 LDLR 3'UTR 절제 세포 대비 PCSK9 변형 세포에서 측정되었다. 도 6e. LDL-콜레스테롤 흡수 - 16시간 동안 로바스타틴의 첨가의 존재 또는 부재 하에, 4시간 동안 이들 세포에서 488-LDL 콜레스테롤 흡수를 측정했다.
도 7a-7c: LDLR 발현의 상향 조절에 필수적인 LDLR 3' UTR의 영역을 확인하기 위해, 인간 간암종 세포주 HepG2에서 특정 sgRNA와 SpCas9의 여러 상이한 조합을 사용하여 LDLR 3'UTR의 부분들을 절제했다. 절제 후, 세포를 mRNA 및 표면 단백질 LDLR 발현 수준에 대해 분석하였다. 도 7a. 테스트된 각 가이드에 대해 각 개별 sgRNA의 편집 비율은 >90%였다. 도 7b. ddPCR로 측정한 LDLR 3'UTR의 절제 비율(적용가능한 경우, 4개의 반복실험(quadruplicate)), qRT-PCR로 측정한 LDLR의 mRNA 수준(2개의 반복실험(duplicates)으로 표시), 및 LDLR 3' UTR 절단 각각에 대한 특정 항체를 이용한 유동 세포 측정법에 의해 측정된 LDLR 막 단백질 발현 수준(3개의 반복실험(triplicates)으로 표시). LDLR 발현(Rq 값)에 대한 sgRNA 쌍의 효과를 포함한, 도 7a 및 도 7b에 표시된 LDLR 3'UTR 절제 실험의 절단 맵이 도 7c에 도시된다.
도 8a-8d: 가이드 g46 및 g79를 갖는 OMNI-50 리보핵산단백질(RNP) 복합체에 의한 HepG2 세포에서 LDLR 3'UTR의 절제. 간략하게, LDLR 유전자의 3'UTR은 인간 세포주 HepG2에서 특정 가이드와 OMNI-50 CRISPR 뉴클레아제를 사용하여 절제되었다. 절제 후, 세포를 LDLR 발현 수준 및 LDL-콜레스테롤 흡수에 대해 분석하였다. 도 8a. ddPCR 측정에 따른 LDLR 3'UTR의 % 절제. 도 8b. qRT-PCR로 측정한 LDLR의 mRNA 수준. 도 8c. LDLR 특이적 항체를 이용한 유동 세포 측정법으로 측정한 LDLR 막 단백질 발현 수준. 도 8d. 로바스타틴 존재 또는 부재 하에 4시간 인큐베이션 후 유동 세포 측정법으로 측정한 LDL-Dylight-488-콜레스테롤의 흡수.
도 9a-9d: 가이드 g38 및 g79를 갖는 OMNI-79 리보핵산단백질(RNP) 복합체의 도입 또는 OMNI-79 코딩 mRNA 분자 및 가이드 g38 및 g79를 포함하는 RNA 조성물의 도입에 의한 HepG2 세포에서 LDLR 3'UTR의 절단. 간략하게, LDLR 유전자의 3'UTR은 특정 가이드와 OMNI-79 CRISPR 뉴클레아제를 사용하여 HepG2에서 절제되었다. 절제 후, 세포를 LDLR 발현 수준 및 LDL-콜레스테롤 흡수에 대해 분석하였다. 도 9a. ddPCR 측정에 따른 LDLR 3'UTR의 % 절제. 도 9b. qRT-PCR로 측정한 LDLR의 mRNA 수준. 도 9c. LDLR 특이적 항체를 이용한 유동 세포 측정법으로 측정한 LDLR 막 단백질 발현 수준. 도 9d. 로바스타틴의 존재 또는 부재 하에 4시간 인큐베이션 후 유동 세포 측정법으로 측정한 LDL-Dylight-488-콜레스테롤의 흡수.
도 10: 본 발명의 구체예에 따른 CRISPR 기반 LDLR 3'UTR 절제 전략의 도식.
도 2a-2d: 환자로부터의 이형접합성 LDLR-돌연변이 LCL 세포: 두 환자 모두에서 표면 수용체의 수준 감소가 확인되었다. 돌연변이 환자 LCL 세포주 대 WT 세포에서 막 LDLR의 유세포 측정 분석 (도 2a). % 발현은 WT LCL 세포에 대한 해당 값 중 각 세포주의 기하 평균의 백분율로 계산되었다 (도 2b). GM1488 돌연변이를 갖는 FH 환자 LCL 세포는 Gly197 [ΔG197]의 결실에 해당했고 (도 2c), 및 GM1460 돌연변이를 갖는 FH 환자 LCL 세포는 코돈 646에서 시스테인의 티로신으로의 치환[C646Y]에 해당했다 (도 2d).
도 3a-3d: 이형접합성 FH 환자 LCL 세포에서 LDLR 3' UTR의 절제는 표면 LDLR의 상향조절 및 콜레스테롤 흡수의 증가를 가져온다. LDLR 유전자의 3' UTR은 이형접합성 FH 환자 유래 LCL 세포주에서 특정 가이드(g1 및 g9) 및 SpCas9를 사용하여 절제되었다. 절제 후, 세포를 LDLR 발현 수준 및 LDL-콜레스테롤 흡수에 대해 분석하였다. 도 3a. ddPCR로 측정한 LDLR 3' UTR의 절제 비율. 도 3b. qRT-PCR로 측정한 LDLR의 mRNA 수준. 도 3c. 특정 항체를 사용하여 유동 세포 측정법으로 측정한 LDLR 표면 단백질 발현 수준. 도 3d. 4시간 인큐베이션 후 유동 세포 측정법으로 측정한 LDL-Dylight-488-콜레스테롤의 흡수.
도 4a-4c: 마우스 간세포주 Hepa1-6에서 LDLR의 3' UTR 절제는 인간 간 HepG2 세포에 적합한(compatible) 결과를 보여준다. LDLR 유전자의 3' UTR은 마우스 간암 세포주 Hepa1-6에서 특정 가이드(g1m 및 g6m) 및 SpCas9를 사용하여 절제되었다. 절제 후, 세포를 LDLR 발현 수준 및 LDL-콜레스테롤 흡수에 대해 분석하였다. 도 4a. qRT-PCR로 측정한 LDLR의 mRNA 수준. 도 4b. 특정 항체를 사용하여 유동 세포 측정법으로 측정한 LDLR 표면 단백질 발현 수준. 도 4c. 4시간 인큐베이션 후 유동 세포 측정법으로 측정한 LDL-Dylight-488-콜레스테롤의 흡수.
도 5a-5c: 3'UTR 영역의 LDLR OMNI -79 CRISPR 뉴클레아제 기반 가이드 스크린. 도 5a. HeLa 세포에서 WT OMNI-79 또는 OMNI-79 V5570을 사용한, LDLR의 표시된 영역 3' UTR을 표적으로 하는 가이드의 형질감염 기반 가이드 스크린. 수개의 가이드는 높은 수준의 편집을 보였고, RNP 또는 RNA 조성물로서 추가로 평가된다. 도 5b. HeLa 세포에서, OMNI-103을 사용한, LDLR의 표시된 영역 3' UTR을 표적으로 하는 가이드의 형질감염 기반 가이드 스크린. OMNI-103 CRISPR 뉴클레아제를 사용하는 복수의 가이드 분자의 높은 활성. 도 5c. 가이드 분자 LDLR 표적 부위의 도식(schematic).
도 6a-6e: CRISPR 기반 편집에 의한 PCSK9의 녹아웃 및 HepG2 세포에서 LDLR 발현 및 LDL 흡수에 대한 효과. 도 6a. PCSK9 편집 - HepG2 세포의 편집 수준은 특정 가이드 분자에 의한 PCSK9의 변형 후에 측정되었다. 도 6b. PCSK9 qRT-PCR - PCSK9 편집 후 HepG2 세포에서 PCSK9의 mRNA 수준. 도 6c. 분비된 PCSK9 - WT HepG2 세포와 비교하여 PCSK9-편집 세포에서 PCSK9의 분비를 ELISA로 측정했다. 도 6d. LDLR 발현 - LDLR의 막 발현은 야생형 및 LDLR 3'UTR 절제 세포 대비 PCSK9 변형 세포에서 측정되었다. 도 6e. LDL-콜레스테롤 흡수 - 16시간 동안 로바스타틴의 첨가의 존재 또는 부재 하에, 4시간 동안 이들 세포에서 488-LDL 콜레스테롤 흡수를 측정했다.
도 7a-7c: LDLR 발현의 상향 조절에 필수적인 LDLR 3' UTR의 영역을 확인하기 위해, 인간 간암종 세포주 HepG2에서 특정 sgRNA와 SpCas9의 여러 상이한 조합을 사용하여 LDLR 3'UTR의 부분들을 절제했다. 절제 후, 세포를 mRNA 및 표면 단백질 LDLR 발현 수준에 대해 분석하였다. 도 7a. 테스트된 각 가이드에 대해 각 개별 sgRNA의 편집 비율은 >90%였다. 도 7b. ddPCR로 측정한 LDLR 3'UTR의 절제 비율(적용가능한 경우, 4개의 반복실험(quadruplicate)), qRT-PCR로 측정한 LDLR의 mRNA 수준(2개의 반복실험(duplicates)으로 표시), 및 LDLR 3' UTR 절단 각각에 대한 특정 항체를 이용한 유동 세포 측정법에 의해 측정된 LDLR 막 단백질 발현 수준(3개의 반복실험(triplicates)으로 표시). LDLR 발현(Rq 값)에 대한 sgRNA 쌍의 효과를 포함한, 도 7a 및 도 7b에 표시된 LDLR 3'UTR 절제 실험의 절단 맵이 도 7c에 도시된다.
도 8a-8d: 가이드 g46 및 g79를 갖는 OMNI-50 리보핵산단백질(RNP) 복합체에 의한 HepG2 세포에서 LDLR 3'UTR의 절제. 간략하게, LDLR 유전자의 3'UTR은 인간 세포주 HepG2에서 특정 가이드와 OMNI-50 CRISPR 뉴클레아제를 사용하여 절제되었다. 절제 후, 세포를 LDLR 발현 수준 및 LDL-콜레스테롤 흡수에 대해 분석하였다. 도 8a. ddPCR 측정에 따른 LDLR 3'UTR의 % 절제. 도 8b. qRT-PCR로 측정한 LDLR의 mRNA 수준. 도 8c. LDLR 특이적 항체를 이용한 유동 세포 측정법으로 측정한 LDLR 막 단백질 발현 수준. 도 8d. 로바스타틴 존재 또는 부재 하에 4시간 인큐베이션 후 유동 세포 측정법으로 측정한 LDL-Dylight-488-콜레스테롤의 흡수.
도 9a-9d: 가이드 g38 및 g79를 갖는 OMNI-79 리보핵산단백질(RNP) 복합체의 도입 또는 OMNI-79 코딩 mRNA 분자 및 가이드 g38 및 g79를 포함하는 RNA 조성물의 도입에 의한 HepG2 세포에서 LDLR 3'UTR의 절단. 간략하게, LDLR 유전자의 3'UTR은 특정 가이드와 OMNI-79 CRISPR 뉴클레아제를 사용하여 HepG2에서 절제되었다. 절제 후, 세포를 LDLR 발현 수준 및 LDL-콜레스테롤 흡수에 대해 분석하였다. 도 9a. ddPCR 측정에 따른 LDLR 3'UTR의 % 절제. 도 9b. qRT-PCR로 측정한 LDLR의 mRNA 수준. 도 9c. LDLR 특이적 항체를 이용한 유동 세포 측정법으로 측정한 LDLR 막 단백질 발현 수준. 도 9d. 로바스타틴의 존재 또는 부재 하에 4시간 인큐베이션 후 유동 세포 측정법으로 측정한 LDL-Dylight-488-콜레스테롤의 흡수.
도 10: 본 발명의 구체예에 따른 CRISPR 기반 LDLR 3'UTR 절제 전략의 도식.
실험적 세부사항
실시예 1: 일반적인 LDLR 변형 분석
서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함하는 가이드 서열을 인간 세포에서 SpCas9를 사용하여 높은 온타켓 활성에 대해 스크리닝한다. 온타겟 활성은 DNA 모세관 전기영동 분석에 의해 결정한다.
실시예 2: LDLR 3' UTR 변형 개념 증명(Proof of Concept)
LDL-C의 평생 상승을 특징으로 하는 가족성 고콜레스테롤혈증(FH)은 85-90%의 케이스에서 LDLR 유전자의 병원성 돌연변이로 인해 유발된다(L. Jiang et al, 2015; A.K. Soutar and R.P. Naoumova, 2007).
본 실시예에 제시된 데이터는 LDLR 유전자의 3'UTR 영역의 결실(도 1a)이 RNA 및 단백질 수준 모두에서 LDLR 유전자 산물의 발현을 증가시키고 시험관 내에서 콜레스테롤 흡수를 증가시켰다는 것을 보여준다(도 1b, 도 1c, 및 도 1d). 형광 표지된 LDL-콜레스테롤의 세포 흡수 동역학은 야생형 및 3'UTR 절제 HepG2 세포에서 유동 세포 측정법을 이용하여 측정하였다. 테스트한 모든 시점에서 3' UTR 절제 후 콜레스테롤 흡수의 2배 증가가 관찰되었다(도 1e). 또한 도 1f-1h, 도 7a-7c, 도 8a-8d, 및 도 9a-9d를 참조한다.
LDLR 3'UTR 절제 전략에 대한 생체 외 개념 증명(proof of concept)은 EBV로 형질전환된 림프모세포성 B 세포주인 FH 환자 유래 LCL 세포에서 확립되었다. 이러한 세포는 유도(derivation)의 용이성, 탁월한 성장(facile growth) 및 게놈 안정성과 같은 질병 모델로서의 사용에서 여러 장점을 갖는다. 이들 세포에서 LDLR의 존재도(abundance) 및 기능성도 입증되었다(PC Chan et al. 1997).
FH 이형접합성 개체를 나타내는 두 개의 세포주를 규명했다. 첫 번째 세포주인 GM1448은 △G197 돌연변이를 갖고, ClinVarMiner에 따르면 이 돌연변이는 리투아니아 아쉬게나지 유대인 집단(Lithuanian Ashkenazi Jewish population)의 창시자(founder) 돌연변이로 알려져 있고 FH에 영향을 받은 71개의 아쉬케나지 유대인 가족 중 35%에서 관찰되었다. 기능적 연구는 이 변이체가 골지체로의 단백질 수송 결함을 유발하고, 돌연변이 단백질은 동형접합성 개체의 세포에서 2% 미만의 LDLR 활성을 나타낸다는 것을 보여주었다. 두 번째 세포주인 GM1460은 2000G>A 치환으로 부터 초래된 C646Y에서의 미스센스 돌연변이를 갖는다. ClinVarMiner에 따르면, 이 돌연변이는 LDLR의 가공을 감소시켜, 동형접합성 개체에서 수용체의 약 20%가 성숙한 형태로 가공된다(도 2a-2d).
FH 환자 LCL 세포에서 SpCas9 및 특정 가이드 RNA 분자에 의한 LDLR 3'UTR의 절제는 비처리 세포에 비해 LDLR mRNA, LDLR 표면 단백질 및 콜레스테롤 흡수의 상향 조절을 유발했다(도 3a-3d).
생체 내 개념 증명으로 동물 모델 선택을 위해, 마우스 Hepa1-6 헤파토사이트에서 3'UTR 절제 전략을 검증하였다. 마우스 편집 조성물을 사용한 마우스 LDLR 유전자의 3'UTR의 절제는 표면 LDLR의 상향 조절 및 콜레스테롤 흡수의 증가를 초래했다 (도 4a-4c).
대안적인 CRISPR 뉴클레아제를 사용한 편집 조성물도 LDLR 편집에서의 사용에 대해 검증되었다. LDLR의 3'UTR을 변경하는 가이드 RNA 분자를 HeLa 세포에서 DNA 형질감염 방법을 이용하여, (1) 참조에 의해 그 내용이 본원에 포함된, PCT 국제 출원 공개 번호 WO/2020/223513에 기술된 OMNI-50 CRISPR 뉴클레아제, (2) 참조에 의해 그 내용이 본원에 포함된, PCT 국제 출원 공개 번호 WO/2021/248016에 기술된 OMNI-79 CRISPR 뉴클레아제, (3) OMNI-79 V5570으로 지칭되는 OMNI-79 CRISPR 뉴클레아제의 증진된 활성 변이체, 및 (4) OMNI-103 CRISPR 뉴클레아제로 스크리닝했다(도 5a-5c). OMNI-79 V5570은 테스트된 대부분의 sgRNA에 대해 편집 수준을 향상시키는 것으로 밝혀졌다. 테스트한 모든 뉴클레아제에 대해 수개의 고활성 가이드가 확인되었다.
표 2: 대안적인
OMNI
CRISPR
뉴클레아제, PAM 요건, 및
sgRNA
스캐폴드
서열
| OMNI CRISPR 뉴클레아제 및 gRNA | PAM 서열 | sgRNA 스캐폴드 서열 |
| OMNI-50 (서열번호 10749) |
NGG | GUUUGAGAGUUAUGUAAGAAAUUACAUGACGAGUUCAAAUAAAAAUUUAUUCAAAACCGCCUAUUUAUAGGCCGCAGAUGUUCUGCAUUAUGCUUGCUAUUGCAAGCUUUUUU (서열번호 10750) |
| OMNI-79 (서열번호 10744) |
NGR | GUUGCCGCUGGAGAAAUCCAGUUGUUAACAAGCAGCUUGACUGCACCAAAUAAGGCGGGGGGCUGCGGCCCUCGCUUUUUU (서열번호 10747) |
| OMNI-79 V5570 (서열번호 10745) |
NGR | GUUGCCGCUGGAGAAAUCCAGUUGUUAACAAGCAGCUUGACUGCACCAAAUAAGGCGGGGGGCUGCGGCCCUCGCUUUUUU (서열번호 10747) |
| OMNI-103 (서열번호 10746) |
NNRACT | GUUUGAGAGUAGUGUAAGAAAUUACACUACAAGUUCAAAUAAAAAUUUAUUCAAAUCCAUUUGCUACAUUGUGUAGAAUUUAAAGAUCUGGCAACAGAUCUUUUUUU(서열번호 10748) |
표 3: 활용된
LDLR
-
표적화
가이드 서열 부분 및
CRISPR
뉴클레아제
|
활용된
뉴클레아제 |
가이드
명칭 |
가이드 서열 부분 | PAM | 인간 게놈 위치 | 정지 코돈/또는 폴리A 신호로부 터의 거리(bp) | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA35 (g35) |
GGACAGUGCCCAUGCAAUGGCU (서열번호 9375) |
TGGGTT | 19:11131462 | 정지 코돈으로부터 170 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA38 (g38) |
AUCCCAACCCAAGCCAUUGCAU (서열번호 7871) |
GGGCAC | 19:11131467 | 정지 코돈으로부터 153 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA40 (g40) |
AAUCCCAACCCAAGCCAUUGCA (서열번호 7340) |
TGGGCA | 19:11131468 | 정지 코돈으로부터 154 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA44 (g44) |
CCUGUUUCUCUUAUCCUUCACG (서열번호 8585) |
AGGAAA | 19:11131508 | 정지 코돈으로부터 194 | |
| OMNI-79 또는 OMNI-50 | sgRNA46 (g46) |
AGGAUAAGAGAAACAGGCCCGG (서열번호 7707) |
GGGGAC | 19:11131519 | 정지 코돈으로부터 227 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA47 (g47) |
GGAUAAGAGAAACAGGCCCGGG (서열번호 9409) |
GGGACC | 19:11131520 | 정지 코돈으로부터 228 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA48 (g48) |
GAUGACACCUCCAUUUCUCUCC (서열번호 9133) |
AGGAAG | 19:11131550 | 정지 코돈으로부터 261 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA49 (g49) |
AAAACUUCCUGGAGAGAAAUGG (서열번호 7134) |
AGGTGT | 19:11131554 | 정지 코돈으로부터 243 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA50 (g50) |
CUCAAAACUUCCUGGAGAAA (서열번호 8725) |
TGGAGG | 19:11131557 | 정지 코돈으로부터 246 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA52 (g52) |
AUGUUUGAGGAUUGUGUCACGG (서열번호 7963) |
TGGAGA | 19:11131589 | 정지 코돈으로부터 278 | |
| OMNI-79 또는 OMNI-50 | sgRNA53 (g53) |
UCCAUGUUUGAGGAUUGUGUCA (서열번호 10059) |
CGGTGG | 19:11131592 | 정지 코돈으로부터 281 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA56 (g56) |
UUUUCUGUCGUGUGUGUUGGGA (서열번호 10723) |
TGGGAT | 19:11132195 | 해당 없음(N/A) | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA59 (g59) |
UGUUGGGAUGGGAUCCCAGGCC (서열번호 10486) |
AGGGAA | 19:11132209 | 해당 없음 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA60 (g60) |
GUUGGGAUGGGAUCCCAGGCCA (서열번호 9839) |
GGGAAA | 19:11132210 | 해당 없음 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA76 (g76) |
GAAGCCACUCAUACAUACAACG (서열번호 8967) |
GGGACA | 19:11133699 | 폴리A 신호로부터 96 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA77 (g77) |
AGAAGCCACUCAUACAUACAAC (서열번호 7603) |
GGGGAC | 19:11133700 | 폴리A 신호로부터 95 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA79 (g79) |
GUUGUAUGUAUGAGUGGCUUCU (서열번호 9843) |
GGGAGA | 19:11133713 | 폴리A 신호로부터 67 | |
| OMNI-79 V5570 또는 OMNI-50 | sgRNA81 (g81) |
GUAUGAGUGGCUUCUGGGAGAU (서열번호 9673) |
GGGTGT | 19:11133706 | 폴리A 신호로부터 60 | |
| OMNI-103 | sgRNA89 (g89) |
GUGUCACGGUGGAGAGAAACUC (서열번호 9794) |
AAAACT | 19:11131576 | 정지 코돈으로부터 259 | |
| OMNI-103 | sgRNA90 (g90) |
GAGGAUUGUGUCACGGUGGAGA (서열번호 9085) |
GAAACT | 19:11131583 | 정지 코돈으로부터 265 | |
| OMNI-103 | sgRNA91 (g91) |
ACCAAUCUCUAAGCCAAACCCC (서열번호 7460) |
TAAACT | 19:11131718 | 정지 코돈으로부터 429 | |
| OMNI-103 | sgRNA92 (g92) |
UUGCAUAGAAGAGGUAAACACG (서열번호 10613) |
TTGACT | 19:11131750 | 정지 코돈으로부터 433 | |
| OMNI-103 | sgRNA93 (g93) |
GAAUCCGUGGUGGCACCGAGAC (서열번호 8985) |
CAAACT | 19:11131909 | 정지 코돈으로부터 624 | |
| OMNI-103 | sgRNA94 (g94) |
UAAUAAAUAUUAAGGGUGACCA (서열번호 9903) |
GTGACT | 19:11131976 | 정지 코돈으로부터 663 | |
| OMNI-103 | sgRNA95 (g95) |
AAAUGUACACAGUGUACAACUC (서열번호 7206) |
TGAACT | 19:11132141 | 해당 없음 | |
| OMNI-103 | sgRNA96 (g96) |
AAAUGCCAAAUGUACACAGUGU (서열번호 7201) |
ACAACT | 19:11132148 | 해당 없음 | |
| OMNI-103 | sgRNA97 (g97) |
GACAGAGAGGGGGCAGGUUGACC (서열번호 9007) |
GGGACT | 19:11132260 | 해당 없음 | |
| OMNI-103 | sgRNA98 (g98) |
AAAGCCGUGAUCGUGAAUAUCG (서열번호 7175) |
AGAACT | 19:11132290 | 해당 없음 | |
| OMNI-103 | sgRNA100 (g100) |
UGCCACCGUACCCAGCUGAUUU (서열번호 10301) |
TTAACT | 19:11133039 | 해당 없음 | |
| OMNI-103 | sgRNA101 (g101) |
AUGAAGACCCUAUUUCAGAAAU (서열번호 7904) |
ACAACT | 19:11133181 | 해당 없음 | |
| OMNI-103 | sgRNA102 (g102) |
CCUCCAGUCUGGAUCGUUUGAC (서열번호 8537) |
GGGACT | 19:11133227 | 해당 없음 | |
| OMNI-103 | sgRNA104 (g103) |
GAGAGACAGUGACAGCCUCCGU (서열번호 9067) |
CAGACT | 19:11133301 | 폴리A 신호로부터 469 | |
| SpCas9 | sgRNA1 (g1) |
CAGUGCCCAUGCAAUGGCUU (서열번호 1120) |
GGGTTG | 19:11131463 | 정지 코돈으로부터 171 | |
| SpCas9 | sgRNA2 (g2) |
AUUCAUCUGGGAGGCAGAAC (서열번호 860) |
AGGCTT | 19:11131433 | 정지 코돈으로부터 141 | |
| SpCas9 | sgRNA3 (g3) |
AAGGAUAAGAGAACAGGCC (서열번호 181) |
CGGGGG | 19:11131516 | 정지 코돈으로부터 224 | |
| SpCas9 | sgRNA4 (g4) |
AACCCUUCCUGAGACCUCGC (서열번호 119) |
CGGCCT | 19:11131345 | 정지코돈으로부터 53 | |
| SpCas9 | sgRNA6 (g6) |
CAAAACUUCCUGGAGAGAAA (서열번호 901) |
TGGAGG | 19:11131557 | 정지 코돈으로부터 243 | |
| SpCas9 | sgRNA7 (g7) |
GAGAGAAACUCAAAACUUCC (서열번호 1927) |
TGGAGA | 19:11131567 | 정지 코돈으로부터 253 | |
| SpCas9 | sgRNA8 (g8) |
GUUACUGUUGCACUGAUGUC (서열번호 2656) |
CGGAGA | 19:11133279 | 폴리A 신호로부터 502 | |
| SpCas9 | sgRNA9 (g9) |
AUGAGUGGCUUCUGGGAGAU (서열번호 796) |
GGGTGT | 19:11133713 | 폴리A 신호로부터 60 | |
| SpCas9 | sgRNA14 (g14) |
AGAAAGUGCAAGGAGACCAC (서열번호 477) |
GGGAAT | 19:11132114 | 정지 코돈으로부터 800 | |
| SpCas9 | sgRNA19 (g19) |
GAGAAAGUGCAAGGAGACCA (서열번호 1913) |
CGGGAA | 19:11132115 | 정지 코돈으로부터 801 | |
| SpCas9 | sgRNA20 (g20) |
CUCUGAACUGAGAAAGUGCA (서열번호 1640) |
AGGAGA | 19:11132124 | 정지 코돈으로부터 810 | |
| SpCas9 | sgRNA22 (g22) |
UAGGCUUGUGGGACACUACA (서열번호 10736) |
GGGGAT | 범위를 벗어남 | 3'UTR의 하류 | |
| SpCas9 | sgRNA82 (g82) |
GGAAGUGGGUAGGGGUCGGG (서열번호 2219) |
AGGATG | 19:11132088 | 정지 코돈으로부터 774 | |
| SpCas9 | sgRNA83 (g83) |
AAUGGAAGUGGGUAGGGGUC (서열번호 247) |
GGGAGG | 19:11132091 | 정지 코돈으로부터 777 | |
| SpCas9 | sgRNA84 (g84) |
GAAUGGAAGUGGGUAGGGGU (서열번호 1853) |
CGGGAG | 19:11132092 | 정지 코돈으로부터 778 | |
| SpCas9 | sgRNA85 (g85) |
CAUCUCUUAAAAAAUGAAUU (서열번호 1151) |
TGGCCA | 19:11132889 | 해당 없음 | |
| SpCas9 | sgRNA86 (g86) |
AAAUGAAUUUGGCCAGACAC (서열번호 76) |
AGGTGC | 19:11132901 | 해당 없음 | |
| SpCas9 | sgRNA1m (g1m) |
GAGCAACACAGAGCCCAGGG (서열번호 10737) |
AGGTGG | 해당 없음(마우스 특이적) | 해당 없음 | |
| SpCas9 | sgRNA6m (g6m) |
GUGCGUUGCUUUGAGUGGGU (서열번호 10738) |
GGGAAC | 해당 없음(마우스 특이적) | 해당 없음 | |
실시예
3: 결과 요약 -
CRISPR
-기반 유전자 편집은 가족성 고콜레스테롤혈증에서 LDLR 발현을 증진시키고 LDL-C 흡수를 증가시킨다.
가족성 고콜레스테롤혈증(FH)은 저밀도 지질단백질 콜레스테롤(LDL-C)의 평생 상승을 특징으로 하는 상염색체 우성 질환으로, 이로 인해 조기 발병 죽상경화증과 관상동맥 질환(coronary events)이 발생한다. 유전적으로 확인된 FH의 약 85% 내지 90%는 LDLR 유전자의 병원성 돌연변이에 의해 발생하며, 그의 반수체 기능부전(haploinsufficiency)은 LDL-C 흡수를 감소시킨다. 현재 스타틴, 에제티미브(Exetimibe)와 같은 평생 지질-저하 약물이 현재 이용가능하나. 이들은 종종 일부 환자에 의해 불내성이고, 원하는 LDL-C 수준에 도달하지 못한다. 보다 최근의 치료 접근법은 LDLR 리소좀 분해를 촉진하는 단백질인 PCSK9(Proprotein Covertase Subtilisin/Kexin type 9)를 일시적으로 억제하는 피하 주사 단일클론 항체에 기반한다. 염기 편집(base editing)에 의한 PCSK9의 영구적 억제가 현재 개발되고 있으나, FH의 발병 근거도 아닌 유전자의 비가역적 넉다운의 장기적인 결과는 아직 알려지지 않았다. 또한, 이러한 접근법은 단독요법으로는 부족한 경우가 많아 스타틴 요법과 병용하여 처방된다.
본 개시는 LDLR 발현을 음성적으로 조절하는 부위를 포함하는, LDLR 3' UTR의 적어도 일부를 절제함으로써 LDLR 발현을 상향조절하기 위한 CRISPR 기반 유전자 편집 전략을 제시한다.
이 편집 전략은 HepG2 세포주, FH 환자 유래 림프구성 세포주(LCL) 및 마우스 간암종 세포주(Hepa1-6)에서 테스트되었다. LDLR 3'UTR의 절제는 ddPCR에 의해 확인되었고, LDLR mRNA 수준은 qRT-PCR에 의해 정량되었다. 총 LDLR 수준 및 막 결합 LDLR 수준은 특이적 항체를 사용하여 각각 웨스턴 블롯 및 유동 세포 측정법으로 결정하였다. 마지막으로, 유동 세포 측정법을 이용하여 형광 표지된 LDL-C의 세포 흡수를 측정함으로써 콜레스테롤 흡수에 대한 LDLR 3'UTR 절제의 효과를 평가했다.
HepG2 세포의 절제 효율은 약 60%였다. 절제된 세포는 비-처리 세포에 비해 LDLR mRNA 수준의 3 내지 6배 상향 조절, 및 막 결합 LDLR의 3배 증가를 보였다. LDLR 3'UTR 절제는 테스트된 모든 시점에서 콜레스테롤 흡수가 2배 증가하는 결과를 가져왔다. 환자 유래 LCL도 비슷한 결과를 보여, LDL-C 흡수가 3-4배 증가했다. LDL-C 흡수의 증가로 이어지는 LDLR mRNA 수준 및 막 단백질 발현의 증가가 절제된 마우스 간 세포주에서도 관찰되었으며, 이는 생체 내 마우스 모델(in vivo mouse model)에서 편집 전략의 향후 평가를 추가로 뒷받침한다. 비교 분석은 이 전략이 콜레스테롤 흡수 증가에 있어 PCSK9 녹아웃 및 스타틴을 능가한다는 것을 보여주었다.
이러한 발견은 LDLR 발현을 증진시키고 LDL-C 흡수를 증가시키기 위해 빠른 LDLR mRNA 전환(turnover)을 담당하는 영역을 절단하는 CRISPR-기반 유전자 편집 전략을 뒷받침한다. 이 독특한 접근법은 다양한 고콜레스테롤혈증 관련 장애에 유용할 수 있다.
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SEQUENCE LISTING
<110> EmendoBio Inc.
<120> COMPOSITIONS AND METHODS FOR TREATING HYPERCHOLESTEROLEMIA
<130> 91709-A-PCT/GJG/AWG
<150> 63/304,170
<151> 2022-01-28
<150> 63/164,396
<151> 2021-03-22
<160> 10758
<170> PatentIn version 3.5
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<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 26
aaacaaggcc ggcgaggucu 20
<210> 27
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 27
aaacacguug acuccugagu 20
<210> 28
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 28
aaacaggccc ggggggacca 20
<210> 29
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 29
aaacauaaca aaaaaucccc 20
<210> 30
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 30
aaacaugcac ggugaggccg 20
<210> 31
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 31
aaacauggaa gaugaaaggg 20
<210> 32
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 32
aaaccaaaaa guuaaaaauc 20
<210> 33
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 33
aaaccaaaau cccaacccaa 20
<210> 34
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 34
aaaccacugu auagaagguu 20
<210> 35
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 35
aaaccagaaa ggcuuaucac 20
<210> 36
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 36
aaaccaugca uggugcauca 20
<210> 37
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 37
aaacccaccu cgaaagacac 20
<210> 38
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 38
aaaccccuaa acucaggagu 20
<210> 39
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 39
aaacccuggu ugcuguauuu 20
<210> 40
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 40
aaacgaucca gacuggagga 20
<210> 41
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 41
aaacucaaaa cuuccuggag 20
<210> 42
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 42
aaacucagga gucaacgugu 20
<210> 43
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 43
aaacucauuc accaaaugau 20
<210> 44
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 44
aaacuuccug gagagaaaug 20
<210> 45
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 45
aaagaaccug aagucccguc 20
<210> 46
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 46
aaagaagagg cauuucagag 20
<210> 47
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 47
aaagacacug ggugggucau 20
<210> 48
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 48
aaagacagag aagaccaaag 20
<210> 49
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 49
aaagacgaca auggcaguuc 20
<210> 50
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 50
aaagauuauu ugcacgaacu 20
<210> 51
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 51
aaagcagugg cauaaucaua 20
<210> 52
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 52
aaagcauugc cugccagagc 20
<210> 53
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 53
aaagccacuu gcuucucugg 20
<210> 54
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 54
aaagccguga ucgugaauau 20
<210> 55
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 55
aaagcguugc acacagucca 20
<210> 56
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 56
aaagcucugg caggcaaugc 20
<210> 57
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 57
aaaggaagaa accaaaaucc 20
<210> 58
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 58
aaaggcuaac cuggcugucu 20
<210> 59
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 59
aaaggcuuau cacgguuccc 20
<210> 60
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 60
aaagggauuc auggcgucgg 20
<210> 61
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 61
aaaggggagg ggaugucagg 20
<210> 62
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 62
aaagugacac ccaucuccca 20
<210> 63
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 63
aaagugcaaa cauaacaaaa 20
<210> 64
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 64
aaagugcaag gagaccacgg 20
<210> 65
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 65
aaaguuaaaa aucagcuggg 20
<210> 66
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 66
aaauaaauaa auccuccagu 20
<210> 67
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 67
aaauaaaucc uccagucugg 20
<210> 68
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 68
aaauacagca accaggguuu 20
<210> 69
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 69
aaauauauaa aacaaagcuc 20
<210> 70
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 70
aaauauuaag ggugaccagu 20
<210> 71
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 71
aaaucagcug gguacggugg 20
<210> 72
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 72
aaaucccaac ccaagccauu 20
<210> 73
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 73
aaauccccac uaucuguaca 20
<210> 74
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 74
aaauccucca gucuggaucg 20
<210> 75
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 75
aaaucgccgu guuacuguug 20
<210> 76
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 76
aaaugaauuu ggccagacac 20
<210> 77
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 77
aaaugaucug gcugaauccg 20
<210> 78
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 78
aaaugaugcc acuucccaga 20
<210> 79
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 79
aaaugccaaa uguacacagu 20
<210> 80
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 80
aaaugccucc aagccauuca 20
<210> 81
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 81
aaaugccucu ucuuuaugua 20
<210> 82
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 82
aaaugccuga gcucaaacca 20
<210> 83
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 83
aaaugcgucc cuguacagau 20
<210> 84
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 84
aaauggaggu gucauccugg 20
<210> 85
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 85
aaauguacac aguguacaac 20
<210> 86
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 86
aaauucauuu uuuaagagau 20
<210> 87
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 87
aacaaaaaau ccccacuauc 20
<210> 88
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 88
aacaaagcuc uggcaggcaa 20
<210> 89
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 89
aacaaauaca gcaaccaggg 20
<210> 90
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 90
aacaaggccg gcgaggucuc 20
<210> 91
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 91
aacacaaaug ccaaauguac 20
<210> 92
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 92
aacacacaac agcagauggc 20
<210> 93
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 93
aacacacacg acagaaaaca 20
<210> 94
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 94
aacacauacc caucaacgac 20
<210> 95
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 95
aacacggcga uuucagaaag 20
<210> 96
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 96
aacacguuga cuccugaguu 20
<210> 97
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 97
aacagaugaa gacccuauuu 20
<210> 98
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 98
aacagcagau ggcaccaacg 20
<210> 99
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 99
aacaggcccg gggggaccag 20
<210> 100
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 100
aacaggcuuc ggacagugcc 20
<210> 101
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 101
aacaguaaca cggcgauuuc 20
<210> 102
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 102
aacaguuuca accaauauac 20
<210> 103
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 103
aacauaacaa aaaaucccca 20
<210> 104
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 104
aacaucugcc uggagucccg 20
<210> 105
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 105
aacaugcacg gugaggccgg 20
<210> 106
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 106
aacauggaag augaaagggg 20
<210> 107
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 107
aaccaaaaag uuaaaaauca 20
<210> 108
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 108
aaccaaaauc ccaacccaag 20
<210> 109
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 109
aaccacugua uagaagguuu 20
<210> 110
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 110
aaccagaaag gcuuaucacg 20
<210> 111
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 111
aaccaggguu ugcaaaaaua 20
<210> 112
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 112
aaccauccuc ccaccucagc 20
<210> 113
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 113
aaccaugcau ggugcaucag 20
<210> 114
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 114
aacccaagcc auugcauggg 20
<210> 115
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 115
aacccaccuc gaaagacacu 20
<210> 116
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 116
aacccccuac acagggcccc 20
<210> 117
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 117
aaccccuaaa cucaggaguc 20
<210> 118
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 118
aacccugguu gcuguauuug 20
<210> 119
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 119
aacccuuccu gagaccucgc 20
<210> 120
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 120
aaccgggugu cucaggcacu 20
<210> 121
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 121
aaccgugaua agccuuucug 20
<210> 122
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 122
aaccugaagu cccgucaaac 20
<210> 123
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 123
aaccugcccc ucucuguccc 20
<210> 124
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 124
aaccuggcug ucuagcaagg 20
<210> 125
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 125
aaccuucuau acagugguuu 20
<210> 126
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 126
aacgacaaga uuggggaagu 20
<210> 127
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 127
aacgauccag acuggaggau 20
<210> 128
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 128
aacgcuuuuu gggagaauga 20
<210> 129
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 129
aacgggaccc ccuggcccug 20
<210> 130
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 130
aacggggaca ucauucuccc 20
<210> 131
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 131
aacguguuua ccucuucuau 20
<210> 132
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 132
aacucaaaac uuccuggaga 20
<210> 133
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 133
aacucaagug auccagcuca 20
<210> 134
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 134
aacucaggag ucaacguguu 20
<210> 135
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 135
aacucauuca ccaaaugaug 20
<210> 136
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 136
aacuccugaa cucaagugau 20
<210> 137
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 137
aacucugaac ugagaaagug 20
<210> 138
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 138
aacugagaaa gugcaaggag 20
<210> 139
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 139
aacugccauu gucgucuuua 20
<210> 140
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 140
aacuggacug ugugcaacgc 20
<210> 141
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 141
aacuuccugg agagaaaugg 20
<210> 142
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 142
aacuuuuugg uuuuuguaga 20
<210> 143
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 143
aagaaaccaa aaucccaacc 20
<210> 144
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 144
aagaaccuga agucccguca 20
<210> 145
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 145
aagaagaggc auuucagagg 20
<210> 146
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 146
aagacacugg gugggucaug 20
<210> 147
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 147
aagacagaga agaccaaagc 20
<210> 148
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 148
aagacauuca ggcuacaaaa 20
<210> 149
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 149
aagaccaaag cauugccugc 20
<210> 150
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 150
aagaccccau cucuuaaaaa 20
<210> 151
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 151
aagacccuau uucagaaaua 20
<210> 152
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 152
aagacgacaa uggcaguucu 20
<210> 153
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 153
aagagaaaca ggcccggggg 20
<210> 154
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 154
aagaggcauu ucagaggcaa 20
<210> 155
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 155
aagagguaaa cacguugacu 20
<210> 156
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 156
aagaugaaag gggaggggau 20
<210> 157
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 157
aagaugucac aagggauugg 20
<210> 158
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 158
aagauuauuu gcacgaacug 20
<210> 159
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 159
aagauugggg aagugaaugg 20
<210> 160
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 160
aagcaagugg cuuucaacac 20
<210> 161
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 161
aagcacuagg ugggcggaca 20
<210> 162
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 162
aagcaguggc auaaucauag 20
<210> 163
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 163
aagcauugcc ugccagagcu 20
<210> 164
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 164
aagccaaacc ccuaaacuca 20
<210> 165
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 165
aagccacuca uacauacaac 20
<210> 166
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 166
aagccacuug cuucucuggg 20
<210> 167
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 167
aagccaggaa agggauucau 20
<210> 168
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 168
aagccauuca cuuccccaau 20
<210> 169
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 169
aagccauugc augggcacug 20
<210> 170
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 170
aagcccgugu caaugaaugc 20
<210> 171
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 171
aagccgugau cgugaauauc 20
<210> 172
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 172
aagccuguuc ugccucccag 20
<210> 173
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 173
aagccuugcu agacagccag 20
<210> 174
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 174
aagccuuucu gguuucggag 20
<210> 175
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 175
aagcgagauc ccaucucuac 20
<210> 176
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 176
aagcguugca cacaguccag 20
<210> 177
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 177
aagcucuggc aggcaaugcu 20
<210> 178
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 178
aaggaagaaa ccaaaauccc 20
<210> 179
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 179
aaggaaggua caaacccacc 20
<210> 180
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 180
aaggagacca cgggaaugga 20
<210> 181
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 181
aaggauaaga gaaacaggcc 20
<210> 182
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 182
aaggccggcg aggucucagg 20
<210> 183
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 183
aaggcuaacc uggcugucua 20
<210> 184
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 184
aaggcuuauc acgguucccu 20
<210> 185
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 185
aaggcuugca uagaagaggu 20
<210> 186
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 186
aagggauuca uggcgucgga 20
<210> 187
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 187
aagggauugg caauuguccc 20
<210> 188
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 188
aaggggaggg gaugucaggc 20
<210> 189
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 189
aagggugacc agugacucag 20
<210> 190
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 190
aaggguucug ggcagggacg 20
<210> 191
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 191
aagguaaccg ggugucucag 20
<210> 192
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 192
aagguacaaa cccaccucga 20
<210> 193
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 193
aagguuuuug uagccugaau 20
<210> 194
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 194
aagucccggu caaccugccc 20
<210> 195
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 195
aagucccguc aaacgaucca 20
<210> 196
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 196
aagugaaugg cuuggaggca 20
<210> 197
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 197
aagugacacc caucucccag 20
<210> 198
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 198
aagugaucca gcucagccuc 20
<210> 199
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 199
aagugcaaac auaacaaaaa 20
<210> 200
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 200
aagugcaagg agaccacggg 20
<210> 201
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 201
aagugccuga gacacccggu 20
<210> 202
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 202
aaguggaagc acuagguggg 20
<210> 203
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 203
aaguggcauc auuuggugaa 20
<210> 204
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 204
aaguggcuuu caacacacaa 20
<210> 205
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 205
aaguggguag gggucgggag 20
<210> 206
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 206
aaguuaaaaa ucagcugggu 20
<210> 207
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 207
aaguuuugag uuucucucca 20
<210> 208
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 208
aauaaaacaa ggccggcgag 20
<210> 209
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 209
aauaaauaaa uccuccaguc 20
<210> 210
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 210
aauaaauauu aagggugacc 20
<210> 211
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 211
aauaaauccu ccagucugga 20
<210> 212
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 212
aauaacacaa augccaaaug 20
<210> 213
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 213
aauaaccccc uacacagggc 20
<210> 214
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 214
aauacagcaa ccaggguuug 20
<210> 215
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 215
aauagucacu gaacaaauac 20
<210> 216
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 216
aauauauaaa acaaagcucu 20
<210> 217
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 217
aauaucgaga acugccauug 20
<210> 218
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 218
aauauuaagg gugaccagug 20
<210> 219
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 219
aauauuuauu aagugccuga 20
<210> 220
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 220
aaucagcugg guacgguggc 20
<210> 221
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 221
aaucauagcu cacgacagcc 20
<210> 222
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 222
aaucaugacc cacccagugu 20
<210> 223
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 223
aaucccaacc caagccauug 20
<210> 224
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 224
aauccccacu aucuguacag 20
<210> 225
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 225
aaucccuugu gacaucuuca 20
<210> 226
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 226
aaucccuuuc cuggcuuaag 20
<210> 227
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 227
aauccguggu ggcaccgaga 20
<210> 228
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 228
aauccucaaa cauggaagau 20
<210> 229
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 229
aauccuccag ucuggaucgu 20
<210> 230
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 230
aaucgccgug uuacuguugc 20
<210> 231
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 231
aaucuauuua uuuuugcaaa 20
<210> 232
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 232
aaucucuaag ccaaaccccu 20
<210> 233
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 233
aaucuugucg uugaugggua 20
<210> 234
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 234
aaucuuugua cauaaagaag 20
<210> 235
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 235
aaugaauuug gccagacaca 20
<210> 236
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 236
aaugaguuug gucucggugc 20
<210> 237
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 237
aaugaucugg cugaauccgu 20
<210> 238
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 238
aaugaugcca cuucccagag 20
<210> 239
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 239
aaugaugucc ccguuguaug 20
<210> 240
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 240
aaugccaaau guacacagug 20
<210> 241
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 241
aaugccgggg acagagaggg 20
<210> 242
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 242
aaugccucca agccauucac 20
<210> 243
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 243
aaugccucuu cuuuauguac 20
<210> 244
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 244
aaugccugag cucaaaccau 20
<210> 245
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 245
aaugcguccc uguacagaua 20
<210> 246
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 246
aaugcuuugg ucuucucugu 20
<210> 247
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 247
aauggaagug gguagggguc 20
<210> 248
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 248
aauggaggug ucauccuggu 20
<210> 249
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 249
aauggcaguu cucgauauuc 20
<210> 250
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 250
aauggcuugg aggcauuugc 20
<210> 251
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 251
aauggcuugg guugggauuu 20
<210> 252
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 252
aauguacaca guguacaacu 20
<210> 253
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 253
aauucauuuu uuaagagaug 20
<210> 254
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 254
aauugaucac aguaagacau 20
<210> 255
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 255
aauugccaau cccuugugac 20
<210> 256
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 256
aauugucccc agggacaaaa 20
<210> 257
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 257
aauuuggcca gacacaggug 20
<210> 258
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 258
acaaaaaauc cccacuaucu 20
<210> 259
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 259
acaaaaaccu ucuauacagu 20
<210> 260
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 260
acaaacccac cucgaaagac 20
<210> 261
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 261
acaaagauua uuugcacgaa 20
<210> 262
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 262
acaaagcucu ggcaggcaau 20
<210> 263
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 263
acaaauacag caaccagggu 20
<210> 264
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 264
acaaaugcca aauguacaca 20
<210> 265
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 265
acaacagcag auggcaccaa 20
<210> 266
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 266
acaacgggga caucauucuc 20
<210> 267
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 267
acaacucuga acugagaaag 20
<210> 268
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 268
acaagauugg ggaagugaau 20
<210> 269
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 269
acaaggccgg cgaggucuca 20
<210> 270
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 270
acaagggauu ggcaauuguc 20
<210> 271
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 271
acaauccuca aacauggaag 20
<210> 272
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 272
acaauggcag uucucgauau 20
<210> 273
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 273
acaauugcca aucccuugug 20
<210> 274
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 274
acacaaaugc caaauguaca 20
<210> 275
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 275
acacaacagc agauggcacc 20
<210> 276
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 276
acacaauccu caaacaugga 20
<210> 277
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 277
acacacaaca gcagauggca 20
<210> 278
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 278
acacacacga cagaaaacag 20
<210> 279
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 279
acacacgaca gaaaacagug 20
<210> 280
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 280
acacagggcc ccgagaauag 20
<210> 281
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 281
acacaggugc cucacgccug 20
<210> 282
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 282
acacagucca guucgugcaa 20
<210> 283
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 283
acacagugua caacucugaa 20
<210> 284
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 284
acacaguguu uugucccugg 20
<210> 285
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 285
acacauaccc aucaacgaca 20
<210> 286
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 286
acaccagccu ggugcccauc 20
<210> 287
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 287
acacccaucu cccagaagcc 20
<210> 288
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 288
acacccgguu accuuggccg 20
<210> 289
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 289
acaccuccau uucucuccag 20
<210> 290
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 290
acaccugggu gcaggccacg 20
<210> 291
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 291
acacgacaga aaacagugca 20
<210> 292
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 292
acacggcgau uucagaaaga 20
<210> 293
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 293
acacgggcuu ucccuggccu 20
<210> 294
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 294
acacguggcc ugcacccagg 20
<210> 295
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 295
acacguugac uccugaguuu 20
<210> 296
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 296
acacugggug ggucaugauu 20
<210> 297
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 297
acacugugua cauuuggcau 20
<210> 298
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 298
acagagaaga ccaaagcauu 20
<210> 299
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 299
acagagaggg gcagguugac 20
<210> 300
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 300
acagauagug gggauuuuuu 20
<210> 301
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 301
acagaugaag acccuauuuc 20
<210> 302
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 302
acagaugguc agucuggagg 20
<210> 303
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 303
acagcaacca ggguuugcaa 20
<210> 304
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 304
acagcagaug gcaccaacgg 20
<210> 305
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 305
acagccacac cugggugcag 20
<210> 306
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 306
acagccaggu uagccuuugc 20
<210> 307
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 307
acagccucaa augccugagc 20
<210> 308
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 308
acagccuccg ucagacuccc 20
<210> 309
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 309
acaggcccgg ggggaccagg 20
<210> 310
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 310
acaggcguga ggcaccugug 20
<210> 311
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 311
acaggcuucg gacagugccc 20
<210> 312
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 312
acagggacgc auuuacgugc 20
<210> 313
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 313
acagggcaaa ggcuaaccug 20
<210> 314
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 314
acagggcccc gagaauaguc 20
<210> 315
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 315
acaggugccu cacgccugua 20
<210> 316
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 316
acaguaacac ggcgauuuca 20
<210> 317
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 317
acaguaagac auucaggcua 20
<210> 318
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 318
acaguccagu ucgugcaaau 20
<210> 319
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 319
acagugacag ccuccgucag 20
<210> 320
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 320
acagugcaaa auaauaacac 20
<210> 321
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 321
acagugccca ugcaauggcu 20
<210> 322
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 322
acagugguuu aaaaagugac 20
<210> 323
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 323
acaguguaca acucugaacu 20
<210> 324
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 324
acaguguuuu gucccugggg 20
<210> 325
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 325
acaguuucaa ccaauauaca 20
<210> 326
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 326
acauaaagaa gaggcauuuc 20
<210> 327
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 327
acauaaagac gacaauggca 20
<210> 328
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 328
acauaacaaa aaauccccac 20
<210> 329
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 329
acauacaacg gggacaucau 20
<210> 330
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 330
acauacccau caacgacaag 20
<210> 331
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 331
acaucagugc aacaguaaca 20
<210> 332
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 332
acaucauucu cccaaaaagc 20
<210> 333
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 333
acauccccuc cccuuucauc 20
<210> 334
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 334
acaucugccu ggagucccgu 20
<210> 335
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 335
acaucuucac gcgggagucu 20
<210> 336
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 336
acaugcacgg ugaggccggg 20
<210> 337
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 337
acauggaaga ugaaagggga 20
<210> 338
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 338
acauucaggc uacaaaaacc 20
<210> 339
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 339
accaaaaagu uaaaaaucag 20
<210> 340
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 340
accaaaaucc caacccaagc 20
<210> 341
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 341
accaaagcau ugccugccag 20
<210> 342
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 342
accaaaugau gccacuuccc 20
<210> 343
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 343
accaacggga cccccuggcc 20
<210> 344
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 344
accaauauac aaagugcaaa 20
<210> 345
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 345
accaaucucu aagccaaacc 20
<210> 346
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 346
accacggauu cagccagauc 20
<210> 347
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 347
accacgggaa uggaaguggg 20
<210> 348
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 348
accacuguau agaagguuuu 20
<210> 349
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 349
accagaaagg cuuaucacgg 20
<210> 350
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 350
accagccugg ugcccauccu 20
<210> 351
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 351
accaggauga caccuccauu 20
<210> 352
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 352
accaggccug agcaacaaag 20
<210> 353
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 353
accaggcugg uguccugaca 20
<210> 354
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 354
accaggguuu gcaaaaauaa 20
<210> 355
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 355
accagugacu caggcucugc 20
<210> 356
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 356
accauccucc caccucagcc 20
<210> 357
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 357
accaugcaug gugcaucagc 20
<210> 358
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 358
acccaagcca uugcaugggc 20
<210> 359
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 359
acccacccag ugucuuucga 20
<210> 360
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 360
acccaccucg aaagacacug 20
<210> 361
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 361
acccacuucc auucccgugg 20
<210> 362
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 362
acccagcuga uuuuuaacuu 20
<210> 363
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 363
acccaggugu ggcugucagg 20
<210> 364
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 364
acccaguguc uuucgaggug 20
<210> 365
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 365
acccaucaac gacaagauug 20
<210> 366
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 366
acccaucucc cagaagccac 20
<210> 367
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 367
accccaucuc uuaaaaaaug 20
<210> 368
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 368
acccccgaau caugacccac 20
<210> 369
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 369
acccccuaca cagggccccg 20
<210> 370
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 370
acccccuggc ccugccucau 20
<210> 371
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 371
accccuaaac ucaggaguca 20
<210> 372
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 372
acccgguuac cuuggccgug 20
<210> 373
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 373
acccugguug cuguauuugu 20
<210> 374
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 374
acccuuaaua uuuauuaagu 20
<210> 375
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 375
acccuuccug agaccucgcc 20
<210> 376
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 376
accgggacuu caaagccgug 20
<210> 377
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 377
accggguguc ucaggcacuu 20
<210> 378
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 378
accguaccca gcugauuuuu 20
<210> 379
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 379
accgugacac aauccucaaa 20
<210> 380
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 380
accgugauaa gccuuucugg 20
<210> 381
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 381
accgugcaug uuuuaaacac 20
<210> 382
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 382
accuagugcu uccacuucua 20
<210> 383
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 383
accucagccu cgccaugccu 20
<210> 384
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 384
accuccauuu cucuccagga 20
<210> 385
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 385
accucgaaag acacugggug 20
<210> 386
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 386
accucgccgg ccuuguuuua 20
<210> 387
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 387
accucuucua ugcaagccuu 20
<210> 388
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 388
accugaaguc ccgucaaacg 20
<210> 389
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 389
accugccccu cucugucccc 20
<210> 390
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 390
accuggcugu cuagcaaggc 20
<210> 391
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 391
accugggugc aggccacgug 20
<210> 392
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 392
accugugucu ggccaaauuc 20
<210> 393
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 393
accuuccuua agccaggaaa 20
<210> 394
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 394
accuucuaua cagugguuua 20
<210> 395
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 395
accuuggccg ugaggacacg 20
<210> 396
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 396
acgaacugga cugugugcaa 20
<210> 397
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 397
acgacaagau uggggaagug 20
<210> 398
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 398
acgacaaugg caguucucga 20
<210> 399
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 399
acgacagaaa acagugcaaa 20
<210> 400
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 400
acgacagccu caaaugccug 20
<210> 401
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 401
acgaggaaag gaagaaacca 20
<210> 402
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 402
acgaucacgg cuuugaaguc 20
<210> 403
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 403
acgauccaga cuggaggauu 20
<210> 404
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 404
acgcauuuac gugcuccgaa 20
<210> 405
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 405
acgccacguc auccuccaga 20
<210> 406
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 406
acgccaugaa ucccuuuccu 20
<210> 407
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 407
acgcgggagu cugacggagg 20
<210> 408
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 408
acgcuuuuug ggagaaugau 20
<210> 409
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 409
acggaggcug ucacugucuc 20
<210> 410
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 410
acggauucag ccagaucauu 20
<210> 411
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 411
acggccaagg uaaccgggug 20
<210> 412
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 412
acggcgauuu cagaaagaac 20
<210> 413
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 413
acggcuuuga agucccgguc 20
<210> 414
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 414
acgggaaugg aaguggguag 20
<210> 415
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 415
acgggacccc cuggcccugc 20
<210> 416
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 416
acgggacucc aggcagaugu 20
<210> 417
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 417
acgggacuuc agguucuuuc 20
<210> 418
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 418
acgggcuuuc ccuggccugg 20
<210> 419
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 419
acggggacau cauucuccca 20
<210> 420
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 420
acggugaggc cgggcgcagu 20
<210> 421
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 421
acgguggaga gaaacucaaa 20
<210> 422
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 422
acguaaaugc gucccuguac 20
<210> 423
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 423
acgucauccu ccagacugac 20
<210> 424
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 424
acgugccacc guacccagcu 20
<210> 425
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 425
acgugcuccg aaaccagaaa 20
<210> 426
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 426
acguggccug cacccaggug 20
<210> 427
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 427
acguggcgug aacaucugcc 20
<210> 428
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 428
acguguccuc acggccaagg 20
<210> 429
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 429
acguguuuac cucuucuaug 20
<210> 430
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 430
acguugacuc cugaguuuag 20
<210> 431
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 431
acuagguggg cggacauaaa 20
<210> 432
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 432
acuaucugua cagggacgca 20
<210> 433
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 433
acuauucucg gggcccugug 20
<210> 434
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 434
acucaaaacu uccuggagag 20
<210> 435
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 435
acucaaguga uccagcucag 20
<210> 436
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 436
acucaggagu caacguguuu 20
<210> 437
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 437
acucaggcuc ugccucuggg 20
<210> 438
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 438
acucauacau acaacgggga 20
<210> 439
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 439
acucauucac caaaugaugc 20
<210> 440
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 440
acuccaggca gauguucacg 20
<210> 441
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 441
acucccgcgu gaagauguca 20
<210> 442
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 442
acuccugaac ucaagugauc 20
<210> 443
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 443
acuccugagu uuagggguuu 20
<210> 444
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 444
acucugaacu gagaaagugc 20
<210> 445
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 445
acugaacaaa uacagcaacc 20
<210> 446
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 446
acugagaaag ugcaaggaga 20
<210> 447
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 447
acugaugucc ggagagacag 20
<210> 448
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 448
acugccauug ucgucuuuau 20
<210> 449
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 449
acugcgcccg gccucaccgu 20
<210> 450
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 450
acuggacugu gugcaacgcu 20
<210> 451
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 451
acuggguggg ucaugauucg 20
<210> 452
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 452
acuggucacc cuuaauauuu 20
<210> 453
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 453
acuguauaga agguuuuugu 20
<210> 454
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 454
acuguccgaa gccuguucug 20
<210> 455
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 455
acugucucuc cggacaucag 20
<210> 456
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 456
acuguguaca uuuggcauuu 20
<210> 457
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 457
acugugugca acgcuuuuug 20
<210> 458
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 458
acuguugcac ugauguccgg 20
<210> 459
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 459
acuguuuucu gucgugugug 20
<210> 460
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 460
acuuaauaaa uauuaagggu 20
<210> 461
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 461
acuucaaagc cgugaucgug 20
<210> 462
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 462
acuucagguu cuuucugaaa 20
<210> 463
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 463
acuuccauuc ccguggucuc 20
<210> 464
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 464
acuucccaga ggcagagccu 20
<210> 465
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 465
acuuccccaa ucuugucguu 20
<210> 466
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 466
acuuccugga gagaaaugga 20
<210> 467
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 467
acuucuaugc aaaugccucc 20
<210> 468
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 468
acuugcuucu cugggccuga 20
<210> 469
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 469
acuuugggag gcugagcugg 20
<210> 470
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 470
acuuuuuaaa ccacuguaua 20
<210> 471
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 471
acuuuuuggu uuuuguagag 20
<210> 472
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 472
agaaacaggc ccggggggac 20
<210> 473
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 473
agaaaccaaa aucccaaccc 20
<210> 474
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 474
agaaacucaa aacuuccugg 20
<210> 475
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 475
agaaagaacc ugaagucccg 20
<210> 476
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 476
agaaaggcuu aucacgguuc 20
<210> 477
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 477
agaaagugca aggagaccac 20
<210> 478
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 478
agaaauggag gugucauccu 20
<210> 479
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 479
agaacaggcu ucggacagug 20
<210> 480
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 480
agaacccuuc cugagaccuc 20
<210> 481
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 481
agaaccugaa gucccgucaa 20
<210> 482
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 482
agaacugcca uugucgucuu 20
<210> 483
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 483
agaagaccaa agcauugccu 20
<210> 484
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 484
agaagaggca uuucagaggc 20
<210> 485
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 485
agaagaggua aacacguuga 20
<210> 486
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 486
agaagcaagu ggcuuucaac 20
<210> 487
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 487
agaagccacu cauacauaca 20
<210> 488
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 488
agaagguuuu uguagccuga 20
<210> 489
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 489
agaaguggaa gcacuaggug 20
<210> 490
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 490
agaauaguca cugaacaaau 20
<210> 491
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 491
agaaugaugu ccccguugua 20
<210> 492
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 492
agacacaggu gccucacgcc 20
<210> 493
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 493
agacacccgg uuaccuuggc 20
<210> 494
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 494
agacacuggg ugggucauga 20
<210> 495
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 495
agacagagaa gaccaaagca 20
<210> 496
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 496
agacagaugg ucagucugga 20
<210> 497
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 497
agacagccag guuagccuuu 20
<210> 498
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 498
agacagugac agccuccguc 20
<210> 499
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 499
agacauucag gcuacaaaaa 20
<210> 500
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 500
agaccaaacu cauucaccaa 20
<210> 501
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 501
agaccaaagc auugccugcc 20
<210> 502
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 502
agaccacggg aauggaagug 20
<210> 503
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 503
agaccaggcc ugagcaacaa 20
<210> 504
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 504
agaccccauc ucuuaaaaaa 20
<210> 505
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 505
agacccuauu ucagaaauac 20
<210> 506
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 506
agaccucgcc ggccuuguuu 20
<210> 507
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 507
agacgacaau ggcaguucuc 20
<210> 508
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 508
agacucccgc gugaagaugu 20
<210> 509
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 509
agagaaacag gcccgggggg 20
<210> 510
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 510
agagaaacuc aaaacuuccu 20
<210> 511
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 511
agagaaaugg aggugucauc 20
<210> 512
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 512
agagaagacc aaagcauugc 20
<210> 513
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 513
agagaagcaa guggcuuuca 20
<210> 514
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 514
agagacagug acagccuccg 20
<210> 515
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 515
agagaggggc agguugaccg 20
<210> 516
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 516
agagauggga ucucgcuuug 20
<210> 517
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 517
agagauuggu ggaugaggca 20
<210> 518
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 518
agagccugag ucacugguca 20
<210> 519
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 519
agaggcaaua acccccuaca 20
<210> 520
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 520
agaggcagag ccugagucac 20
<210> 521
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 521
agaggcauuu cagaggcaau 20
<210> 522
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 522
agaggccaug ggcugcugau 20
<210> 523
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 523
agaggggcag guugaccggg 20
<210> 524
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 524
agagguaaac acguugacuc 20
<210> 525
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 525
agaguuguac acuguguaca 20
<210> 526
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 526
agauaguggg gauuuuuugu 20
<210> 527
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 527
agaucauuuc cgacgccaug 20
<210> 528
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 528
agaugaaagg ggaggggaug 20
<210> 529
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 529
agaugaagac ccuauuucag 20
<210> 530
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 530
agauggcacc aacgggaccc 20
<210> 531
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 531
agaugggauc ucgcuuuguu 20
<210> 532
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 532
agaugggugu cacuuuuuaa 20
<210> 533
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 533
agauggucag ucuggaggau 20
<210> 534
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 534
agaugucaca agggauuggc 20
<210> 535
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 535
agauguucac gccacgucau 20
<210> 536
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 536
agauuauuug cacgaacugg 20
<210> 537
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 537
agauugggga agugaauggc 20
<210> 538
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 538
agauuggugg augaggcagg 20
<210> 539
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 539
agcaaccagg guuugcaaaa 20
<210> 540
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 540
agcaaggcuu gcauagaaga 20
<210> 541
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 541
agcaaguggc uuucaacaca 20
<210> 542
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 542
agcacguaaa ugcgucccug 20
<210> 543
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 543
agcacuaggu gggcggacau 20
<210> 544
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 544
agcagauggc accaacggga 20
<210> 545
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 545
agcagcccau ggccucuggc 20
<210> 546
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 546
agcaguggca uaaucauagc 20
<210> 547
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 547
agcauugccu gccagagcuu 20
<210> 548
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 548
agccaaaccc cuaaacucag 20
<210> 549
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 549
agccacaccu gggugcaggc 20
<210> 550
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 550
agccacucau acauacaacg 20
<210> 551
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 551
agccacuugc uucucugggc 20
<210> 552
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 552
agccaggaaa gggauucaug 20
<210> 553
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 553
agccagguua gccuuugccc 20
<210> 554
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 554
agccauucac uuccccaauc 20
<210> 555
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 555
agccauugca ugggcacugu 20
<210> 556
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 556
agcccauggc cucuggccag 20
<210> 557
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 557
agcccguguc aaugaaugcc 20
<210> 558
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 558
agccgugauc gugaauaucg 20
<210> 559
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 559
agccucaaau gccugagcuc 20
<210> 560
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 560
agccuccguc agacucccgc 20
<210> 561
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 561
agccucgcca ugccuggcca 20
<210> 562
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 562
agccugaaug ucuuacugug 20
<210> 563
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 563
agccugaguc acuggucacc 20
<210> 564
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 564
agccuggugc ccauccuccc 20
<210> 565
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 565
agccuguucu gccucccaga 20
<210> 566
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 566
agccuugcua gacagccagg 20
<210> 567
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 567
agccuuucug guuucggagc 20
<210> 568
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 568
agccuuugcc cugucacccc 20
<210> 569
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 569
agcgagaucc caucucuaca 20
<210> 570
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 570
agcguugcac acaguccagu 20
<210> 571
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 571
agcuaugauu augccacugc 20
<210> 572
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 572
agcucacgac agccucaaau 20
<210> 573
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 573
agcucaggca uuugaggcug 20
<210> 574
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 574
agcucuggca ggcaaugcuu 20
<210> 575
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 575
agcuggauca cuugaguuca 20
<210> 576
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 576
aggaaaggaa gaaaccaaaa 20
<210> 577
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 577
aggaaaggga uucauggcgu 20
<210> 578
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 578
aggaagaaac caaaauccca 20
<210> 579
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 579
aggaaggguu cugggcaggg 20
<210> 580
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 580
aggaagguac aaacccaccu 20
<210> 581
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 581
aggaaguuuu gaguuucucu 20
<210> 582
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 582
aggacaccag ccuggugccc 20
<210> 583
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 583
aggacacgug gccugcaccc 20
<210> 584
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 584
aggagaccac gggaauggaa 20
<210> 585
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 585
aggagucaac guguuuaccu 20
<210> 586
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 586
aggaguugga gaccaggccu 20
<210> 587
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 587
aggauaagag aaacaggccc 20
<210> 588
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 588
aggaugacac cuccauuucu 20
<210> 589
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 589
aggaugacgu ggcgugaaca 20
<210> 590
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 590
aggaugggca ccaggcuggu 20
<210> 591
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 591
aggaugguuu gagcucaggc 20
<210> 592
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 592
aggauugugu cacgguggag 20
<210> 593
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 593
aggcaauaac ccccuacaca 20
<210> 594
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 594
aggcaaugcu uuggucuucu 20
<210> 595
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 595
aggcaccugu gucuggccaa 20
<210> 596
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 596
aggcacgugc caccguaccc 20
<210> 597
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 597
aggcacuuaa uaaauauuaa 20
<210> 598
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 598
aggcagaaca ggcuucggac 20
<210> 599
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 599
aggcagagcc ugagucacug 20
<210> 600
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 600
aggcagaugu ucacgccacg 20
<210> 601
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 601
aggcagggcc aggggguccc 20
<210> 602
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 602
aggcauggcg aggcugaggu 20
<210> 603
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 603
aggcauuuca gaggcaauaa 20
<210> 604
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 604
aggcauuuga ggcugucgug 20
<210> 605
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 605
aggcauuugc auagaagugg 20
<210> 606
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 606
aggccacgug uccucacggc 20
<210> 607
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 607
aggccaggga aagcccgugu 20
<210> 608
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 608
aggccauggg cugcugaugc 20
<210> 609
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 609
aggcccagag aagcaagugg 20
<210> 610
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 610
aggcccgggg ggaccaggau 20
<210> 611
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 611
aggccggcga ggucucagga 20
<210> 612
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 612
aggccugagc aacaaagcga 20
<210> 613
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 613
aggccugguc uccaacuccu 20
<210> 614
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 614
aggcgugagg caccuguguc 20
<210> 615
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 615
aggcuaaccu ggcugucuag 20
<210> 616
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 616
aggcuacaaa aaccuucuau 20
<210> 617
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 617
aggcucugcc ucugggaagu 20
<210> 618
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 618
aggcugagcu ggaucacuug 20
<210> 619
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 619
aggcuggaaa gcaguggcau 20
<210> 620
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 620
aggcuggugu ccugacagcc 20
<210> 621
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 621
aggcugucac ugucucuccg 20
<210> 622
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 622
aggcuuauca cgguucccug 20
<210> 623
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 623
aggcuucgga cagugcccau 20
<210> 624
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 624
aggcuugcau agaagaggua 20
<210> 625
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 625
agggaaagcc cgugucaaug 20
<210> 626
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 626
agggaaccgu gauaagccuu 20
<210> 627
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 627
agggacgcau uuacgugcuc 20
<210> 628
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 628
agggacggga cuccaggcag 20
<210> 629
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 629
agggauucau ggcgucggaa 20
<210> 630
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 630
agggauuggc aauugucccc 20
<210> 631
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 631
agggcaaagg cuaaccuggc 20
<210> 632
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 632
agggccaggg ggucccguug 20
<210> 633
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 633
agggccccga gaauagucac 20
<210> 634
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 634
aggggagggg augucaggcc 20
<210> 635
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 635
aggggauguc aggcccagag 20
<210> 636
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 636
aggggcaggu ugaccgggac 20
<210> 637
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 637
aggggguccc guuggugcca 20
<210> 638
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 638
aggggguuau ugccucugaa 20
<210> 639
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 639
aggggucggg aggaugggca 20
<210> 640
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 640
agggguuugg cuuagagauu 20
<210> 641
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 641
agggugacca gugacucagg 20
<210> 642
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 642
aggguucugg gcagggacgg 20
<210> 643
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 643
agguaaacac guugacuccu 20
<210> 644
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 644
agguaaccgg gugucucagg 20
<210> 645
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 645
agguacaaac ccaccucgaa 20
<210> 646
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 646
aggucucagg aaggguucug 20
<210> 647
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 647
aggugggcgg acauaaagac 20
<210> 648
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 648
agguggguuu guaccuuccu 20
<210> 649
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 649
aggugucauc cugguccccc 20
<210> 650
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 650
agguguggcu gucaggacac 20
<210> 651
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 651
agguuagccu uugcccuguc 20
<210> 652
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 652
agguucuuuc ugaaaucgcc 20
<210> 653
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 653
agguugaccg ggacuucaaa 20
<210> 654
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 654
agguuuuugu agccugaaug 20
<210> 655
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 655
aguaacacgg cgauuucaga 20
<210> 656
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 656
aguaagacau ucaggcuaca 20
<210> 657
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 657
aguaagaccc caucucuuaa 20
<210> 658
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 658
agucaacgug uuuaccucuu 20
<210> 659
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 659
agucacugaa caaauacagc 20
<210> 660
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 660
agucacuggu cacccuuaau 20
<210> 661
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 661
aguccaguuc gugcaaauaa 20
<210> 662
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 662
agucccgguc aaccugcccc 20
<210> 663
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 663
agucccguca aacgauccag 20
<210> 664
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 664
agucccgucc cugcccagaa 20
<210> 665
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 665
agucugacgg aggcugucac 20
<210> 666
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 666
agucuggagg augacguggc 20
<210> 667
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 667
agucuggauc guuugacggg 20
<210> 668
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 668
agugaauggc uuggaggcau 20
<210> 669
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 669
agugacaccc aucucccaga 20
<210> 670
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 670
agugacagcc uccgucagac 20
<210> 671
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 671
agugacuauu cucggggccc 20
<210> 672
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 672
agugacucag gcucugccuc 20
<210> 673
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 673
agugauaaca guuucaacca 20
<210> 674
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 674
agugauccag cucagccucc 20
<210> 675
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 675
agugcaaaau aauaacacaa 20
<210> 676
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 676
agugcaaaca uaacaaaaaa 20
<210> 677
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 677
agugcaacag uaacacggcg 20
<210> 678
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 678
agugcaagga gaccacggga 20
<210> 679
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 679
agugcaggga accgugauaa 20
<210> 680
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 680
agugcccaug caauggcuug 20
<210> 681
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 681
agugccugag acacccgguu 20
<210> 682
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 682
agugcuucca cuucuaugca 20
<210> 683
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 683
aguggaagca cuaggugggc 20
<210> 684
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 684
aguggcauca uuuggugaau 20
<210> 685
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 685
aguggcuucu gggagauggg 20
<210> 686
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 686
aguggcuuuc aacacacaac 20
<210> 687
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 687
aguggggauu uuuuguuaug 20
<210> 688
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 688
aguggguagg ggucgggagg 20
<210> 689
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 689
agugguuuaa aaagugacac 20
<210> 690
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 690
aguguacaac ucugaacuga 20
<210> 691
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 691
agugucuuuc gagguggguu 20
<210> 692
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 692
aguguuuugu cccuggggac 20
<210> 693
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 693
aguuaaaaau cagcugggua 20
<210> 694
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 694
aguucagagu uguacacugu 20
<210> 695
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 695
aguucaggag uuggagacca 20
<210> 696
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 696
aguucgugca aauaaucuuu 20
<210> 697
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 697
aguucucgau auucacgauc 20
<210> 698
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 698
aguuggagac caggccugag 20
<210> 699
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 699
aguuguacac uguguacauu 20
<210> 700
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 700
aguuguauuu cugaaauagg 20
<210> 701
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 701
aguuuagggg uuuggcuuag 20
<210> 702
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 702
aguuucaacc aauauacaaa 20
<210> 703
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 703
aguuucucuc caccgugaca 20
<210> 704
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 704
aguuuggucu cggugccacc 20
<210> 705
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 705
aguuuugagu uucucuccac 20
<210> 706
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 706
auaaaacaaa gcucuggcag 20
<210> 707
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 707
auaaaacaag gccggcgagg 20
<210> 708
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 708
auaaagaaga ggcauuucag 20
<210> 709
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 709
auaaagacga caauggcagu 20
<210> 710
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 710
auaaauaaau ccuccagucu 20
<210> 711
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 711
auaaauauua agggugacca 20
<210> 712
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 712
auaaauccuc cagucuggau 20
<210> 713
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 713
auaacaaaaa auccccacua 20
<210> 714
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 714
auaacacaaa ugccaaaugu 20
<210> 715
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 715
auaacccccu acacagggcc 20
<210> 716
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 716
auaagagaaa caggcccggg 20
<210> 717
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 717
auaagccuuu cugguuucgg 20
<210> 718
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 718
auaaucauag cucacgacag 20
<210> 719
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 719
auaaucuuug uacauaaaga 20
<210> 720
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 720
auacaacggg gacaucauuc 20
<210> 721
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 721
auacagcaac caggguuugc 20
<210> 722
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 722
auacaguggu uuaaaaagug 20
<210> 723
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 723
auacauacaa cggggacauc 20
<210> 724
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 724
auacccauca acgacaagau 20
<210> 725
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 725
auagaagagg uaaacacguu 20
<210> 726
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 726
auagaagguu uuuguagccu 20
<210> 727
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 727
auagaagugg aagcacuagg 20
<210> 728
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 728
auagcucacg acagccucaa 20
<210> 729
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 729
auagucacug aacaaauaca 20
<210> 730
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 730
auagugggga uuuuuuguua 20
<210> 731
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 731
auaguuguau uucugaaaua 20
<210> 732
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 732
auauaaaaca aagcucuggc 20
<210> 733
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 733
auauauaaaa caaagcucug 20
<210> 734
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 734
auauauuuau ucaucuggga 20
<210> 735
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 735
auaucgagaa cugccauugu 20
<210> 736
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 736
auauuaaggg ugaccaguga 20
<210> 737
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 737
auauucacga ucacggcuuu 20
<210> 738
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 738
auauuuauua agugccugag 20
<210> 739
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 739
auauuuauuc aucugggagg 20
<210> 740
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 740
aucaacgaca agauugggga 20
<210> 741
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 741
aucacaggca cgugccaccg 20
<210> 742
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 742
aucacaguaa gacauucagg 20
<210> 743
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 743
aucacggcuu ugaagucccg 20
<210> 744
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 744
aucagcagcc cauggccucu 20
<210> 745
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 745
aucagcuggg uacgguggca 20
<210> 746
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 746
aucagugcaa caguaacacg 20
<210> 747
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 747
aucauagcuc acgacagccu 20
<210> 748
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 748
aucaugaccc acccaguguc 20
<210> 749
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 749
aucauucucc caaaaagcgu 20
<210> 750
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 750
aucauuuccg acgccaugaa 20
<210> 751
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 751
aucauuuggu gaaugaguuu 20
<210> 752
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 752
auccaccaau cucuaagcca 20
<210> 753
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 753
auccagacug gaggauuuau 20
<210> 754
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 754
aucccaaccc aagccauugc 20
<210> 755
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 755
aucccaggcc agggaaagcc 20
<210> 756
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 756
aucccauccc aacacacacg 20
<210> 757
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 757
aucccaucuc uacaaaaacc 20
<210> 758
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 758
auccccacua ucuguacagg 20
<210> 759
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 759
auccccuccc cuuucaucuu 20
<210> 760
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 760
aucccuugug acaucuucac 20
<210> 761
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 761
aucccuuucc uggcuuaagg 20
<210> 762
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 762
auccguggug gcaccgagac 20
<210> 763
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 763
auccucaaac auggaagaug 20
<210> 764
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 764
auccuccagu cuggaucguu 20
<210> 765
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 765
auccucccac cucagccucg 20
<210> 766
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 766
auccucccga ccccuaccca 20
<210> 767
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 767
auccuggucc ccccgggccu 20
<210> 768
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 768
auccuucacg aggaaaggaa 20
<210> 769
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 769
aucgagaacu gccauugucg 20
<210> 770
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 770
aucgccgugu uacuguugca 20
<210> 771
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 771
aucgugaaua ucgagaacug 20
<210> 772
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 772
aucguuugac gggacuucag 20
<210> 773
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 773
aucuauuuau uuuugcaaac 20
<210> 774
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 774
aucucccaga agccacucau 20
<210> 775
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 775
aucucgcuuu guugcucagg 20
<210> 776
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 776
aucucuaagc caaaccccua 20
<210> 777
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 777
aucucuuaaa aaaugaauuu 20
<210> 778
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 778
aucugccugg agucccgucc 20
<210> 779
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 779
aucugcuguu guguguugaa 20
<210> 780
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 780
aucuggcuga auccguggug 20
<210> 781
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 781
aucugggagg cagaacaggc 20
<210> 782
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 782
aucuguacag ggacgcauuu 20
<210> 783
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 783
aucuucacgc gggagucuga 20
<210> 784
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 784
aucuuccaug uuugaggauu 20
<210> 785
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 785
aucuugucgu ugauggguau 20
<210> 786
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 786
aucuuuguac auaaagaaga 20
<210> 787
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 787
augaaagggg aggggauguc 20
<210> 788
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 788
augaagaccc uauuucagaa 20
<210> 789
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 789
augaaucccu uuccuggcuu 20
<210> 790
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 790
augaaugccg gggacagaga 20
<210> 791
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 791
augaauuugg ccagacacag 20
<210> 792
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 792
augacaccuc cauuucucuc 20
<210> 793
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 793
augacccacc cagugucuuu 20
<210> 794
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 794
augacguggc gugaacaucu 20
<210> 795
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 795
augaggcagg gccagggggu 20
<210> 796
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 796
augaguggcu ucugggagau 20
<210> 797
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 797
augaguuugg ucucggugcc 20
<210> 798
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 798
augaucuggc ugaauccgug 20
<210> 799
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 799
augauguccc cguuguaugu 20
<210> 800
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 800
augauuaugc cacugcuuuc 20
<210> 801
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 801
augauucggg ggugacaggg 20
<210> 802
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 802
augcaaaugc cuccaagcca 20
<210> 803
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 803
augcaagccu ugcuagacag 20
<210> 804
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 804
augcaauggc uuggguuggg 20
<210> 805
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 805
augcacggug aggccgggcg 20
<210> 806
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 806
augcauggug caucagcagc 20
<210> 807
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 807
augccaaaug uacacagugu 20
<210> 808
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 808
augccacuuc ccagaggcag 20
<210> 809
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 809
augccgggga cagagagggg 20
<210> 810
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 810
augccuccaa gccauucacu 20
<210> 811
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 811
augccucuuc uuuauguaca 20
<210> 812
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 812
augccugagc ucaaaccauc 20
<210> 813
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 813
augccuggcc agaggccaug 20
<210> 814
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 814
augcgucccu guacagauag 20
<210> 815
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 815
augcuuuggu cuucucuguc 20
<210> 816
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 816
auggaagaug aaaggggagg 20
<210> 817
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 817
auggaagugg guaggggucg 20
<210> 818
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 818
auggaggugu cauccugguc 20
<210> 819
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 819
auggcaccaa cgggaccccc 20
<210> 820
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 820
auggcaguuc ucgauauuca 20
<210> 821
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 821
auggccucug gccaggcaug 20
<210> 822
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 822
auggcgaggc ugagguggga 20
<210> 823
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 823
auggcgucgg aaaugaucug 20
<210> 824
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 824
auggcuugga ggcauuugca 20
<210> 825
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 825
auggcuuggg uugggauuuu 20
<210> 826
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 826
augggauccc aggccaggga 20
<210> 827
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 827
augggaucuc gcuuuguugc 20
<210> 828
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 828
augggcacca ggcugguguc 20
<210> 829
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 829
augggcacug uccgaagccu 20
<210> 830
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 830
augggcugcu gaugcaccau 20
<210> 831
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 831
auggguaugu guuuaaaaca 20
<210> 832
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 832
auggguguca cuuuuuaaac 20
<210> 833
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 833
auggucaguc uggaggauga 20
<210> 834
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 834
auggugcauc agcagcccau 20
<210> 835
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 835
augguuugag cucaggcauu 20
<210> 836
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 836
auguacaaag auuauuugca 20
<210> 837
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 837
auguacacag uguacaacuc 20
<210> 838
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 838
auguaugagu ggcuucuggg 20
<210> 839
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 839
augucacaag ggauuggcaa 20
<210> 840
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 840
augucaggcc cagagaagca 20
<210> 841
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 841
auguccccgu uguauguaug 20
<210> 842
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 842
auguccgccc accuagugcu 20
<210> 843
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 843
auguccggag agacagugac 20
<210> 844
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 844
auguguuuaa aacaugcacg 20
<210> 845
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 845
auguucacgc cacgucaucc 20
<210> 846
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 846
auguuugagg auugugucac 20
<210> 847
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 847
auguuugcac uuuguauauu 20
<210> 848
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 848
auguuuuaaa cacauaccca 20
<210> 849
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 849
auuaagggug accagugacu 20
<210> 850
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 850
auuaagugcc ugagacaccc 20
<210> 851
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 851
auuacaggcg ugaggcaccu 20
<210> 852
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 852
auuaugccac ugcuuuccag 20
<210> 853
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 853
auuauuugca cgaacuggac 20
<210> 854
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 854
auucaaagac agagaagacc 20
<210> 855
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 855
auucaccaaa ugaugccacu 20
<210> 856
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 856
auucacgauc acggcuuuga 20
<210> 857
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 857
auucacuucc ccaaucuugu 20
<210> 858
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 858
auucagccag aucauuuccg 20
<210> 859
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 859
auucaggcua caaaaaccuu 20
<210> 860
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 860
auucaucugg gaggcagaac 20
<210> 861
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 861
auucauggcg ucggaaauga 20
<210> 862
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 862
auucauugac acgggcuuuc 20
<210> 863
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 863
auucauuuuu uaagagaugg 20
<210> 864
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 864
auucccgugg ucuccuugca 20
<210> 865
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 865
auucgggggu gacagggcaa 20
<210> 866
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 866
auucucccaa aaagcguugc 20
<210> 867
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 867
auucucgggg cccuguguag 20
<210> 868
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 868
auugacacgg gcuuucccug 20
<210> 869
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 869
auugaucaca guaagacauu 20
<210> 870
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 870
auugcauggg cacuguccga 20
<210> 871
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 871
auugccaauc ccuugugaca 20
<210> 872
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 872
auugccucug aaaugccucu 20
<210> 873
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 873
auuggcaauu guccccaggg 20
<210> 874
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 874
auuggggaag ugaauggcuu 20
<210> 875
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 875
auugguggau gaggcagggc 20
<210> 876
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 876
auugucccca gggacaaaac 20
<210> 877
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 877
auugucgucu uuauguccgc 20
<210> 878
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 878
auugugucac gguggagaga 20
<210> 879
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 879
auuuacgugc uccgaaacca 20
<210> 880
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 880
auuuauuaag ugccugagac 20
<210> 881
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 881
auuuauucau cugggaggca 20
<210> 882
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 882
auuuauuuuu gcaaacccug 20
<210> 883
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 883
auuucagaaa gaaccugaag 20
<210> 884
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 884
auuucagagg caauaacccc 20
<210> 885
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 885
auuuccgacg ccaugaaucc 20
<210> 886
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 886
auuucucucc aggaaguuuu 20
<210> 887
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 887
auuucugaaa uagggucuuc 20
<210> 888
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 888
auuugaggcu gucgugagcu 20
<210> 889
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 889
auuugcacga acuggacugu 20
<210> 890
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 890
auuugcauag aaguggaagc 20
<210> 891
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 891
auuuggccag acacaggugc 20
<210> 892
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 892
auuuggugaa ugaguuuggu 20
<210> 893
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 893
auuuguucag ugacuauucu 20
<210> 894
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 894
auuuugcacu guuuucuguc 20
<210> 895
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 895
auuuugguuu cuuccuuucc 20
<210> 896
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 896
auuuuugcaa acccugguug 20
<210> 897
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 897
caaaaaaucc ccacuaucug 20
<210> 898
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 898
caaaaaccuu cuauacagug 20
<210> 899
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 899
caaaaagcgu ugcacacagu 20
<210> 900
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 900
caaaaaguua aaaaucagcu 20
<210> 901
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 901
caaaacuucc uggagagaaa 20
<210> 902
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 902
caaaauccca acccaagcca 20
<210> 903
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 903
caaacauaac aaaaaauccc 20
<210> 904
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 904
caaacaugga agaugaaagg 20
<210> 905
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 905
caaacccacc ucgaaagaca 20
<210> 906
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 906
caaaccccua aacucaggag 20
<210> 907
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 907
caaacccugg uugcuguauu 20
<210> 908
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 908
caaacgaucc agacuggagg 20
<210> 909
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 909
caaacucauu caccaaauga 20
<210> 910
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 910
caaagacaga gaagaccaaa 20
<210> 911
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 911
caaagauuau uugcacgaac 20
<210> 912
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 912
caaagcauug ccugccagag 20
<210> 913
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 913
caaagccgug aucgugaaua 20
<210> 914
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 914
caaagcucug gcaggcaaug 20
<210> 915
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 915
caaagugcaa acauaacaaa 20
<210> 916
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 916
caaauacagc aaccaggguu 20
<210> 917
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 917
caaaugaugc cacuucccag 20
<210> 918
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 918
caaaugccaa auguacacag 20
<210> 919
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 919
caaaugccuc caagccauuc 20
<210> 920
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 920
caaaugccug agcucaaacc 20
<210> 921
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 921
caaauguaca caguguacaa 20
<210> 922
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 922
caaauucauu uuuuaagaga 20
<210> 923
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 923
caacacacaa cagcagaugg 20
<210> 924
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 924
caacacacac gacagaaaac 20
<210> 925
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 925
caacagauga agacccuauu 20
<210> 926
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 926
caacagcaga uggcaccaac 20
<210> 927
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 927
caacaguaac acggcgauuu 20
<210> 928
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 928
caaccaauau acaaagugca 20
<210> 929
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 929
caaccagggu uugcaaaaau 20
<210> 930
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 930
caacccaagc cauugcaugg 20
<210> 931
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 931
caaccugccc cucucugucc 20
<210> 932
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 932
caacgacaag auuggggaag 20
<210> 933
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 933
caacgcuuuu ugggagaaug 20
<210> 934
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 934
caacgggacc cccuggcccu 20
<210> 935
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 935
caacggggac aucauucucc 20
<210> 936
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 936
caacguguuu accucuucua 20
<210> 937
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 937
caacuccuga acucaaguga 20
<210> 938
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 938
caacucugaa cugagaaagu 20
<210> 939
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 939
caagauuggg gaagugaaug 20
<210> 940
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 940
caagccauuc acuuccccaa 20
<210> 941
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 941
caagccauug caugggcacu 20
<210> 942
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 942
caagccuugc uagacagcca 20
<210> 943
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 943
caaggagacc acgggaaugg 20
<210> 944
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 944
caaggccggc gaggucucag 20
<210> 945
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 945
caaggcuugc auagaagagg 20
<210> 946
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 946
caagggauug gcaauugucc 20
<210> 947
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 947
caagguaacc gggugucuca 20
<210> 948
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 948
caagugaucc agcucagccu 20
<210> 949
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 949
caaguggcuu ucaacacaca 20
<210> 950
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 950
caauaacccc cuacacaggg 20
<210> 951
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 951
caaucccuug ugacaucuuc 20
<210> 952
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 952
caauccucaa acauggaaga 20
<210> 953
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 953
caaucucuaa gccaaacccc 20
<210> 954
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 954
caaucuuguc guugaugggu 20
<210> 955
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 955
caaugaaugc cggggacaga 20
<210> 956
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 956
caaugcuuug gucuucucug 20
<210> 957
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 957
caauggcagu ucucgauauu 20
<210> 958
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 958
caauggcuug gguugggauu 20
<210> 959
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 959
caauugccaa ucccuuguga 20
<210> 960
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 960
caauuguccc cagggacaaa 20
<210> 961
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 961
cacaaaugcc aaauguacac 20
<210> 962
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 962
cacaacagca gauggcacca 20
<210> 963
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 963
cacaagggau uggcaauugu 20
<210> 964
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 964
cacaauccuc aaacauggaa 20
<210> 965
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 965
cacacaacag cagauggcac 20
<210> 966
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 966
cacacacgac agaaaacagu 20
<210> 967
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 967
cacacagucc aguucgugca 20
<210> 968
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 968
cacaccuggg ugcaggccac 20
<210> 969
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 969
cacacgacag aaaacagugc 20
<210> 970
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 970
cacaggcacg ugccaccgua 20
<210> 971
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 971
cacagggccc cgagaauagu 20
<210> 972
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 972
cacaggugcc ucacgccugu 20
<210> 973
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 973
cacaguaaga cauucaggcu 20
<210> 974
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 974
cacaguccag uucgugcaaa 20
<210> 975
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 975
cacaguguac aacucugaac 20
<210> 976
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 976
cacaguguuu ugucccuggg 20
<210> 977
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 977
cacauaccca ucaacgacaa 20
<210> 978
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 978
caccaacggg acccccuggc 20
<210> 979
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 979
caccaaucuc uaagccaaac 20
<210> 980
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 980
caccacggau ucagccagau 20
<210> 981
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 981
caccaggcug guguccugac 20
<210> 982
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 982
cacccaggug uggcugucag 20
<210> 983
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 983
cacccagugu cuuucgaggu 20
<210> 984
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 984
cacccaucuc ccagaagcca 20
<210> 985
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 985
cacccccgaa ucaugaccca 20
<210> 986
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 986
cacccgguua ccuuggccgu 20
<210> 987
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 987
cacccuuaau auuuauuaag 20
<210> 988
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 988
caccgagacc aaacucauuc 20
<210> 989
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 989
caccguaccc agcugauuuu 20
<210> 990
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 990
caccgugaca caauccucaa 20
<210> 991
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 991
caccgugcau guuuuaaaca 20
<210> 992
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 992
caccuagugc uuccacuucu 20
<210> 993
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 993
caccucagcc ucgccaugcc 20
<210> 994
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 994
caccuccauu ucucuccagg 20
<210> 995
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 995
caccucgaaa gacacugggu 20
<210> 996
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 996
caccugggug caggccacgu 20
<210> 997
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 997
caccuguguc uggccaaauu 20
<210> 998
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 998
cacgaacugg acugugugca 20
<210> 999
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 999
cacgacagaa aacagugcaa 20
<210> 1000
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1000
cacgacagcc ucaaaugccu 20
<210> 1001
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1001
cacgaggaaa ggaagaaacc 20
<210> 1002
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1002
cacgaucacg gcuuugaagu 20
<210> 1003
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1003
cacgccacgu cauccuccag 20
<210> 1004
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1004
cacgcgggag ucugacggag 20
<210> 1005
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1005
cacggauuca gccagaucau 20
<210> 1006
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1006
cacggccaag guaaccgggu 20
<210> 1007
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1007
cacggcgauu ucagaaagaa 20
<210> 1008
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1008
cacggcuuug aagucccggu 20
<210> 1009
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1009
cacgggaaug gaagugggua 20
<210> 1010
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1010
cacgggcuuu cccuggccug 20
<210> 1011
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1011
cacggugagg ccgggcgcag 20
<210> 1012
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1012
cacgguggag agaaacucaa 20
<210> 1013
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1013
cacguaaaug cgucccugua 20
<210> 1014
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1014
cacgucaucc uccagacuga 20
<210> 1015
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1015
cacgugccac cguacccagc 20
<210> 1016
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1016
cacguggccu gcacccaggu 20
<210> 1017
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1017
cacguguccu cacggccaag 20
<210> 1018
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1018
cacguugacu ccugaguuua 20
<210> 1019
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1019
cacuaggugg gcggacauaa 20
<210> 1020
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1020
cacuaucugu acagggacgc 20
<210> 1021
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1021
cacucauaca uacaacgggg 20
<210> 1022
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1022
cacugaacaa auacagcaac 20
<210> 1023
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1023
cacugauguc cggagagaca 20
<210> 1024
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1024
cacugcgccc ggccucaccg 20
<210> 1025
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1025
cacugggugg gucaugauuc 20
<210> 1026
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1026
cacuggucac ccuuaauauu 20
<210> 1027
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1027
cacuguauag aagguuuuug 20
<210> 1028
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1028
cacuguccga agccuguucu 20
<210> 1029
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1029
cacugucucu ccggacauca 20
<210> 1030
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1030
cacuguguac auuuggcauu 20
<210> 1031
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1031
cacuguuuuc ugucgugugu 20
<210> 1032
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1032
cacuuaauaa auauuaaggg 20
<210> 1033
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1033
cacuuccauu cccguggucu 20
<210> 1034
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1034
cacuucccag aggcagagcc 20
<210> 1035
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1035
cacuucccca aucuugucgu 20
<210> 1036
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1036
cacuucuaug caaaugccuc 20
<210> 1037
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1037
cacuugcuuc ucugggccug 20
<210> 1038
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1038
cacuuucuca guucagaguu 20
<210> 1039
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1039
cacuuuggga ggcugagcug 20
<210> 1040
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1040
cacuuuguau auugguugaa 20
<210> 1041
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1041
cacuuuuuaa accacuguau 20
<210> 1042
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1042
cagaaaacag ugcaaaauaa 20
<210> 1043
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1043
cagaaagaac cugaaguccc 20
<210> 1044
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1044
cagaaaggcu uaucacgguu 20
<210> 1045
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1045
cagaacaggc uucggacagu 20
<210> 1046
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1046
cagaacccuu ccugagaccu 20
<210> 1047
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1047
cagaagccac ucauacauac 20
<210> 1048
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1048
cagacacagg ugccucacgc 20
<210> 1049
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1049
cagacucccg cgugaagaug 20
<210> 1050
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1050
cagagaagac caaagcauug 20
<210> 1051
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1051
cagagaagca aguggcuuuc 20
<210> 1052
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1052
cagagagggg cagguugacc 20
<210> 1053
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1053
cagagccuga gucacugguc 20
<210> 1054
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1054
cagaggcaga gccugaguca 20
<210> 1055
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1055
cagaggccau gggcugcuga 20
<210> 1056
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1056
cagauagugg ggauuuuuug 20
<210> 1057
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1057
cagaucauuu ccgacgccau 20
<210> 1058
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1058
cagaugaaga cccuauuuca 20
<210> 1059
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1059
cagauggcac caacgggacc 20
<210> 1060
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1060
cagaugguca gucuggagga 20
<210> 1061
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1061
cagauguuca cgccacguca 20
<210> 1062
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1062
cagcaaccag gguuugcaaa 20
<210> 1063
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1063
cagcagaugg caccaacggg 20
<210> 1064
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1064
cagcagccca uggccucugg 20
<210> 1065
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1065
cagccacacc ugggugcagg 20
<210> 1066
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1066
cagccagauc auuuccgacg 20
<210> 1067
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1067
cagccagguu agccuuugcc 20
<210> 1068
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1068
cagcccaugg ccucuggcca 20
<210> 1069
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1069
cagccucaaa ugccugagcu 20
<210> 1070
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1070
cagccuccgu cagacucccg 20
<210> 1071
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1071
cagccucgcc augccuggcc 20
<210> 1072
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1072
cagccuggug cccauccucc 20
<210> 1073
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1073
cagcugggua cgguggcacg 20
<210> 1074
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1074
caggaaaggg auucauggcg 20
<210> 1075
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1075
caggaagggu ucugggcagg 20
<210> 1076
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1076
caggaaguuu ugaguuucuc 20
<210> 1077
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1077
caggacacca gccuggugcc 20
<210> 1078
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1078
caggagucaa cguguuuacc 20
<210> 1079
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1079
caggaguugg agaccaggcc 20
<210> 1080
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1080
caggaugaca ccuccauuuc 20
<210> 1081
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1081
caggcaaugc uuuggucuuc 20
<210> 1082
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1082
caggcacgug ccaccguacc 20
<210> 1083
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1083
caggcacuua auaaauauua 20
<210> 1084
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1084
caggcagaug uucacgccac 20
<210> 1085
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1085
caggcauggc gaggcugagg 20
<210> 1086
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1086
caggcauuug aggcugucgu 20
<210> 1087
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1087
caggccacgu guccucacgg 20
<210> 1088
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1088
caggccaggg aaagcccgug 20
<210> 1089
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1089
caggcccaga gaagcaagug 20
<210> 1090
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1090
caggcccggg gggaccagga 20
<210> 1091
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1091
caggccugag caacaaagcg 20
<210> 1092
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1092
caggccuggu cuccaacucc 20
<210> 1093
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1093
caggcgugag gcaccugugu 20
<210> 1094
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1094
caggcucugc cucugggaag 20
<210> 1095
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1095
caggcuggaa agcaguggca 20
<210> 1096
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1096
caggcuggug uccugacagc 20
<210> 1097
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1097
caggcuucgg acagugccca 20
<210> 1098
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1098
cagggaaagc ccgugucaau 20
<210> 1099
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1099
cagggaaccg ugauaagccu 20
<210> 1100
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1100
cagggacgca uuuacgugcu 20
<210> 1101
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1101
cagggacggg acuccaggca 20
<210> 1102
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1102
cagggcaaag gcuaaccugg 20
<210> 1103
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1103
cagggccagg gggucccguu 20
<210> 1104
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1104
cagggccccg agaauaguca 20
<210> 1105
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1105
cagggggucc cguuggugcc 20
<210> 1106
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1106
cagguuagcc uuugcccugu 20
<210> 1107
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1107
cagguucuuu cugaaaucgc 20
<210> 1108
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1108
cagguugacc gggacuucaa 20
<210> 1109
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1109
caguaacacg gcgauuucag 20
<210> 1110
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1110
caguaagaca uucaggcuac 20
<210> 1111
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1111
caguccaguu cgugcaaaua 20
<210> 1112
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1112
cagucuggag gaugacgugg 20
<210> 1113
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1113
cagucuggau cguuugacgg 20
<210> 1114
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1114
cagugacagc cuccgucaga 20
<210> 1115
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1115
cagugacuau ucucggggcc 20
<210> 1116
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1116
cagugacuca ggcucugccu 20
<210> 1117
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1117
cagugcaaaa uaauaacaca 20
<210> 1118
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1118
cagugcaaca guaacacggc 20
<210> 1119
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1119
cagugcaggg aaccgugaua 20
<210> 1120
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1120
cagugcccau gcaauggcuu 20
<210> 1121
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1121
cagugguuua aaaagugaca 20
<210> 1122
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1122
caguguacaa cucugaacug 20
<210> 1123
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1123
cagugucuuu cgaggugggu 20
<210> 1124
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1124
caguguuuug ucccugggga 20
<210> 1125
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1125
caguucagag uuguacacug 20
<210> 1126
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1126
caguucgugc aaauaaucuu 20
<210> 1127
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1127
caguucucga uauucacgau 20
<210> 1128
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1128
caguuucaac caauauacaa 20
<210> 1129
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1129
cauaaagaag aggcauuuca 20
<210> 1130
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1130
cauaaagacg acaauggcag 20
<210> 1131
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1131
cauaacaaaa aauccccacu 20
<210> 1132
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1132
cauaaucaua gcucacgaca 20
<210> 1133
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1133
cauacaacgg ggacaucauu 20
<210> 1134
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1134
cauacauaca acggggacau 20
<210> 1135
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1135
cauacccauc aacgacaaga 20
<210> 1136
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1136
cauagaagag guaaacacgu 20
<210> 1137
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1137
cauagaagug gaagcacuag 20
<210> 1138
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1138
cauagcucac gacagccuca 20
<210> 1139
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1139
caucaacgac aagauugggg 20
<210> 1140
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1140
caucagcagc ccauggccuc 20
<210> 1141
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1141
caucagugca acaguaacac 20
<210> 1142
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1142
caucauucuc ccaaaaagcg 20
<210> 1143
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1143
caucauuugg ugaaugaguu 20
<210> 1144
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1144
cauccaccaa ucucuaagcc 20
<210> 1145
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1145
caucccaaca cacacgacag 20
<210> 1146
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1146
cauccccucc ccuuucaucu 20
<210> 1147
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1147
cauccuccag acugaccauc 20
<210> 1148
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1148
cauccucccg accccuaccc 20
<210> 1149
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1149
cauccugguc cccccgggcc 20
<210> 1150
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1150
caucucccag aagccacuca 20
<210> 1151
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1151
caucucuuaa aaaaugaauu 20
<210> 1152
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1152
caucugccug gagucccguc 20
<210> 1153
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1153
caucugcugu uguguguuga 20
<210> 1154
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1154
caucugggag gcagaacagg 20
<210> 1155
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1155
caucuucacg cgggagucug 20
<210> 1156
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1156
caucuuccau guuugaggau 20
<210> 1157
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1157
caugaauccc uuuccuggcu 20
<210> 1158
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1158
caugacccac ccagugucuu 20
<210> 1159
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1159
caugauucgg gggugacagg 20
<210> 1160
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1160
caugcaaugg cuuggguugg 20
<210> 1161
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1161
caugcacggu gaggccgggc 20
<210> 1162
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1162
caugcauggu gcaucagcag 20
<210> 1163
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1163
caugccuggc cagaggccau 20
<210> 1164
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1164
cauggaagau gaaaggggag 20
<210> 1165
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1165
cauggccucu ggccaggcau 20
<210> 1166
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1166
cauggcgagg cugagguggg 20
<210> 1167
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1167
cauggcgucg gaaaugaucu 20
<210> 1168
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1168
caugggcacu guccgaagcc 20
<210> 1169
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1169
caugggcugc ugaugcacca 20
<210> 1170
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1170
cauggugcau cagcagccca 20
<210> 1171
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1171
cauguuugag gauuguguca 20
<210> 1172
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1172
cauguuuuaa acacauaccc 20
<210> 1173
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1173
cauucaccaa augaugccac 20
<210> 1174
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1174
cauucacuuc cccaaucuug 20
<210> 1175
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1175
cauucaggcu acaaaaaccu 20
<210> 1176
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1176
cauucauuga cacgggcuuu 20
<210> 1177
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1177
cauucccgug gucuccuugc 20
<210> 1178
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1178
cauucuccca aaaagcguug 20
<210> 1179
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1179
cauugacacg ggcuuucccu 20
<210> 1180
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1180
cauugcaugg gcacuguccg 20
<210> 1181
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1181
cauugccugc cagagcuuug 20
<210> 1182
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1182
cauugucguc uuuauguccg 20
<210> 1183
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1183
cauuuacgug cuccgaaacc 20
<210> 1184
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1184
cauuucagag gcaauaaccc 20
<210> 1185
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1185
cauuuccgac gccaugaauc 20
<210> 1186
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1186
cauuucucuc caggaaguuu 20
<210> 1187
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1187
cauuugaggc ugucgugagc 20
<210> 1188
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1188
cauuugcaua gaaguggaag 20
<210> 1189
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1189
cauuugguga augaguuugg 20
<210> 1190
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1190
cauuuuuuaa gagauggggu 20
<210> 1191
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1191
ccaaaaagcg uugcacacag 20
<210> 1192
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1192
ccaaaaaguu aaaaaucagc 20
<210> 1193
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1193
ccaaaauccc aacccaagcc 20
<210> 1194
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1194
ccaaaccccu aaacucagga 20
<210> 1195
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1195
ccaaacucau ucaccaaaug 20
<210> 1196
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1196
ccaaagcauu gccugccaga 20
<210> 1197
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1197
ccaaaugaug ccacuuccca 20
<210> 1198
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1198
ccaaauguac acaguguaca 20
<210> 1199
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1199
ccaaauucau uuuuuaagag 20
<210> 1200
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1200
ccaacacaca cgacagaaaa 20
<210> 1201
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1201
ccaacccaag ccauugcaug 20
<210> 1202
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1202
ccaacgggac ccccuggccc 20
<210> 1203
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1203
ccaacuccug aacucaagug 20
<210> 1204
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1204
ccaagccauu cacuucccca 20
<210> 1205
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1205
ccaagccauu gcaugggcac 20
<210> 1206
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1206
ccaagguaac cgggugucuc 20
<210> 1207
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1207
ccaauauaca aagugcaaac 20
<210> 1208
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1208
ccaaucccuu gugacaucuu 20
<210> 1209
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1209
ccaaucucua agccaaaccc 20
<210> 1210
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1210
ccaaucuugu cguugauggg 20
<210> 1211
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1211
ccacaccugg gugcaggcca 20
<210> 1212
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1212
ccaccaaucu cuaagccaaa 20
<210> 1213
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1213
ccaccacgga uucagccaga 20
<210> 1214
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1214
ccacccagug ucuuucgagg 20
<210> 1215
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1215
ccaccguacc cagcugauuu 20
<210> 1216
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1216
ccaccgugac acaauccuca 20
<210> 1217
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1217
ccaccuagug cuuccacuuc 20
<210> 1218
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1218
ccaccucagc cucgccaugc 20
<210> 1219
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1219
ccaccucgaa agacacuggg 20
<210> 1220
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1220
ccacggauuc agccagauca 20
<210> 1221
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1221
ccacgggaau ggaagugggu 20
<210> 1222
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1222
ccacgucauc cuccagacug 20
<210> 1223
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1223
ccacgugucc ucacggccaa 20
<210> 1224
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1224
ccacuaucug uacagggacg 20
<210> 1225
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1225
ccacucauac auacaacggg 20
<210> 1226
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1226
ccacugcgcc cggccucacc 20
<210> 1227
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1227
ccacuguaua gaagguuuuu 20
<210> 1228
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1228
ccacuuccau ucccgugguc 20
<210> 1229
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1229
ccacuucuau gcaaaugccu 20
<210> 1230
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1230
ccacuugcuu cucugggccu 20
<210> 1231
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1231
ccagaaaggc uuaucacggu 20
<210> 1232
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1232
ccagaacccu uccugagacc 20
<210> 1233
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1233
ccagaagcca cucauacaua 20
<210> 1234
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1234
ccagacacag gugccucacg 20
<210> 1235
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1235
ccagacugga ggauuuauuu 20
<210> 1236
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1236
ccagagaagc aaguggcuuu 20
<210> 1237
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1237
ccagaggcag agccugaguc 20
<210> 1238
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1238
ccagaggcca ugggcugcug 20
<210> 1239
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1239
ccagaucauu uccgacgcca 20
<210> 1240
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1240
ccagccuggu gcccauccuc 20
<210> 1241
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1241
ccagcugauu uuuaacuuuu 20
<210> 1242
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1242
ccaggaaagg gauucauggc 20
<210> 1243
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1243
ccaggaaguu uugaguuucu 20
<210> 1244
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1244
ccaggaugac accuccauuu 20
<210> 1245
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1245
ccaggcagau guucacgcca 20
<210> 1246
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1246
ccaggcaugg cgaggcugag 20
<210> 1247
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1247
ccaggccagg gaaagcccgu 20
<210> 1248
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1248
ccaggccuga gcaacaaagc 20
<210> 1249
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1249
ccaggcugga aagcaguggc 20
<210> 1250
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1250
ccaggcuggu guccugacag 20
<210> 1251
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1251
ccagggacaa aacacugugu 20
<210> 1252
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1252
ccaggggguc ccguuggugc 20
<210> 1253
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1253
ccaggguuug caaaaauaaa 20
<210> 1254
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1254
ccaggugugg cugucaggac 20
<210> 1255
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1255
ccagguuagc cuuugcccug 20
<210> 1256
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1256
ccagucugga ucguuugacg 20
<210> 1257
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1257
ccagugacuc aggcucugcc 20
<210> 1258
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1258
ccagugcagg gaaccgugau 20
<210> 1259
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1259
ccagugucuu ucgagguggg 20
<210> 1260
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1260
ccaguucgug caaauaaucu 20
<210> 1261
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1261
ccaucaacga caagauuggg 20
<210> 1262
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1262
ccaucccaac acacacgaca 20
<210> 1263
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1263
ccauccuccc accucagccu 20
<210> 1264
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1264
ccauccuccc gaccccuacc 20
<210> 1265
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1265
ccaucuccca gaagccacuc 20
<210> 1266
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1266
ccaucucuac aaaaaccaaa 20
<210> 1267
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1267
ccaucucuua aaaaaugaau 20
<210> 1268
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1268
ccaucugcug uuguguguug 20
<210> 1269
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1269
ccaugaaucc cuuuccuggc 20
<210> 1270
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1270
ccaugcaaug gcuuggguug 20
<210> 1271
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1271
ccaugcaugg ugcaucagca 20
<210> 1272
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1272
ccaugccugg ccagaggcca 20
<210> 1273
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1273
ccauggccuc uggccaggca 20
<210> 1274
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1274
ccaugggcug cugaugcacc 20
<210> 1275
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1275
ccauguuuga ggauuguguc 20
<210> 1276
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1276
ccauucacuu ccccaaucuu 20
<210> 1277
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1277
ccauucccgu ggucuccuug 20
<210> 1278
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1278
ccauugcaug ggcacugucc 20
<210> 1279
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1279
ccauugucgu cuuuaugucc 20
<210> 1280
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1280
ccauuucucu ccaggaaguu 20
<210> 1281
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1281
cccaaaaagc guugcacaca 20
<210> 1282
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1282
cccaacacac acgacagaaa 20
<210> 1283
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1283
cccaagccau ugcaugggca 20
<210> 1284
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1284
cccaaucuug ucguugaugg 20
<210> 1285
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1285
cccacccagu gucuuucgag 20
<210> 1286
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1286
cccaccuagu gcuuccacuu 20
<210> 1287
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1287
cccaccucag ccucgccaug 20
<210> 1288
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1288
cccaccucga aagacacugg 20
<210> 1289
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1289
cccacuaucu guacagggac 20
<210> 1290
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1290
cccacuucca uucccguggu 20
<210> 1291
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1291
cccagaaccc uuccugagac 20
<210> 1292
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1292
cccagaagcc acucauacau 20
<210> 1293
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1293
cccagagaag caaguggcuu 20
<210> 1294
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1294
cccagcugau uuuuaacuuu 20
<210> 1295
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1295
cccaggccag ggaaagcccg 20
<210> 1296
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1296
cccaggcugg aaagcagugg 20
<210> 1297
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1297
cccagggaca aaacacugug 20
<210> 1298
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1298
cccaggugug gcugucagga 20
<210> 1299
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1299
cccagugcag ggaaccguga 20
<210> 1300
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1300
cccagugucu uucgaggugg 20
<210> 1301
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1301
cccaucaacg acaagauugg 20
<210> 1302
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1302
cccaucccaa cacacacgac 20
<210> 1303
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1303
cccauccucc cgaccccuac 20
<210> 1304
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1304
cccaucuccc agaagccacu 20
<210> 1305
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1305
cccaucucua caaaaaccaa 20
<210> 1306
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1306
cccaucucuu aaaaaaugaa 20
<210> 1307
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1307
cccaugcaau ggcuuggguu 20
<210> 1308
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1308
cccauggccu cuggccaggc 20
<210> 1309
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1309
ccccaaucuu gucguugaug 20
<210> 1310
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1310
ccccacuauc uguacaggga 20
<210> 1311
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1311
ccccagugca gggaaccgug 20
<210> 1312
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1312
ccccaucucu uaaaaaauga 20
<210> 1313
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1313
cccccagugc agggaaccgu 20
<210> 1314
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1314
ccccccgggc cuguuucucu 20
<210> 1315
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1315
cccccgaauc augacccacc 20
<210> 1316
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1316
cccccgggcc uguuucucuu 20
<210> 1317
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1317
cccccuacac agggccccga 20
<210> 1318
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1318
cccccuggcc cugccucauc 20
<210> 1319
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1319
ccccgaauca ugacccaccc 20
<210> 1320
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1320
ccccgagaau agucacugaa 20
<210> 1321
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1321
ccccggcauu cauugacacg 20
<210> 1322
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1322
ccccgggccu guuucucuua 20
<210> 1323
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1323
ccccguugua uguaugagug 20
<210> 1324
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1324
ccccuaaacu caggagucaa 20
<210> 1325
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1325
ccccuacaca gggccccgag 20
<210> 1326
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1326
ccccuaccca cuuccauucc 20
<210> 1327
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1327
ccccuccccu uucaucuucc 20
<210> 1328
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1328
ccccucucug uccccggcau 20
<210> 1329
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1329
ccccuggccc ugccucaucc 20
<210> 1330
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1330
ccccuuucau cuuccauguu 20
<210> 1331
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1331
cccgaaucau gacccaccca 20
<210> 1332
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1332
cccgaccccu acccacuucc 20
<210> 1333
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1333
cccgagaaua gucacugaac 20
<210> 1334
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1334
cccgcgugaa gaugucacaa 20
<210> 1335
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1335
cccggcauuc auugacacgg 20
<210> 1336
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1336
cccggccuca ccgugcaugu 20
<210> 1337
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1337
cccgggccug uuucucuuau 20
<210> 1338
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1338
cccgggggga ccaggaugac 20
<210> 1339
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1339
cccggucaac cugccccucu 20
<210> 1340
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1340
cccgguuacc uuggccguga 20
<210> 1341
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1341
cccgucaaac gauccagacu 20
<210> 1342
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1342
cccgucccug cccagaaccc 20
<210> 1343
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1343
cccguggucu ccuugcacuu 20
<210> 1344
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1344
cccgugucaa ugaaugccgg 20
<210> 1345
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1345
cccguuggug ccaucugcug 20
<210> 1346
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1346
cccguuguau guaugagugg 20
<210> 1347
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1347
cccuaaacuc aggagucaac 20
<210> 1348
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1348
cccuacacag ggccccgaga 20
<210> 1349
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1349
cccuacccac uuccauuccc 20
<210> 1350
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1350
cccuccccuu ucaucuucca 20
<210> 1351
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1351
cccucucugu ccccggcauu 20
<210> 1352
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1352
cccugcccag aacccuuccu 20
<210> 1353
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1353
cccugccuca uccaccaauc 20
<210> 1354
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1354
cccuggcccu gccucaucca 20
<210> 1355
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1355
cccuggccug ggaucccauc 20
<210> 1356
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1356
cccuggggac aauugccaau 20
<210> 1357
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1357
cccugguugc uguauuuguu 20
<210> 1358
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1358
cccuguacag auagugggga 20
<210> 1359
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1359
cccugucacc cccgaaucau 20
<210> 1360
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1360
cccuguguag gggguuauug 20
<210> 1361
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1361
cccuuaauau uuauuaagug 20
<210> 1362
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1362
cccuuccuga gaccucgccg 20
<210> 1363
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1363
cccuugugac aucuucacgc 20
<210> 1364
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1364
cccuuucauc uuccauguuu 20
<210> 1365
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1365
cccuuuccug gcuuaaggaa 20
<210> 1366
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1366
ccgaaaccag aaaggcuuau 20
<210> 1367
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1367
ccgaagccug uucugccucc 20
<210> 1368
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1368
ccgaaucaug acccacccag 20
<210> 1369
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1369
ccgaccccua cccacuucca 20
<210> 1370
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1370
ccgacgccau gaaucccuuu 20
<210> 1371
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1371
ccgagaauag ucacugaaca 20
<210> 1372
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1372
ccgcccaccu agugcuucca 20
<210> 1373
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1373
ccgcgugaag augucacaag 20
<210> 1374
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1374
ccggacauca gugcaacagu 20
<210> 1375
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1375
ccggagagac agugacagcc 20
<210> 1376
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1376
ccggcauuca uugacacggg 20
<210> 1377
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1377
ccggccucac cgugcauguu 20
<210> 1378
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1378
ccggccuugu uuuauucaaa 20
<210> 1379
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1379
ccggcgaggu cucaggaagg 20
<210> 1380
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1380
ccgggacuuc aaagccguga 20
<210> 1381
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1381
ccgggccugu uucucuuauc 20
<210> 1382
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1382
ccggggacag agaggggcag 20
<210> 1383
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1383
ccggggggac caggaugaca 20
<210> 1384
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1384
ccgggugucu caggcacuua 20
<210> 1385
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1385
ccggucaacc ugccccucuc 20
<210> 1386
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1386
ccgguuaccu uggccgugag 20
<210> 1387
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1387
ccguacccag cugauuuuua 20
<210> 1388
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1388
ccgucaaacg auccagacug 20
<210> 1389
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1389
ccgucagacu cccgcgugaa 20
<210> 1390
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1390
ccgucccugc ccagaacccu 20
<210> 1391
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1391
ccgugacaca auccucaaac 20
<210> 1392
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1392
ccgugauaag ccuuucuggu 20
<210> 1393
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1393
ccgugaucgu gaauaucgag 20
<210> 1394
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1394
ccgugcaugu uuuaaacaca 20
<210> 1395
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1395
ccgugguggc accgagacca 20
<210> 1396
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1396
ccgugucaau gaaugccggg 20
<210> 1397
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1397
ccguuggugc caucugcugu 20
<210> 1398
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1398
ccguuguaug uaugaguggc 20
<210> 1399
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1399
ccuaaacuca ggagucaacg 20
<210> 1400
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1400
ccuacacagg gccccgagaa 20
<210> 1401
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1401
ccuacccacu uccauucccg 20
<210> 1402
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1402
ccuagugcuu ccacuucuau 20
<210> 1403
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1403
ccucaaacau ggaagaugaa 20
<210> 1404
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1404
ccucaaaugc cugagcucaa 20
<210> 1405
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1405
ccucaccgug cauguuuuaa 20
<210> 1406
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1406
ccucacggcc aagguaaccg 20
<210> 1407
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1407
ccucagccuc gccaugccug 20
<210> 1408
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1408
ccucauccac caaucucuaa 20
<210> 1409
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1409
ccuccaagcc auucacuucc 20
<210> 1410
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1410
ccuccagucu ggaucguuug 20
<210> 1411
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1411
ccuccauuuc ucuccaggaa 20
<210> 1412
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1412
ccucccaccu cagccucgcc 20
<210> 1413
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1413
ccuccccuuu caucuuccau 20
<210> 1414
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1414
ccuccgucag acucccgcgu 20
<210> 1415
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1415
ccucgaaaga cacugggugg 20
<210> 1416
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1416
ccucgccaug ccuggccaga 20
<210> 1417
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1417
ccucgccggc cuuguuuuau 20
<210> 1418
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1418
ccucgugaag gauaagagaa 20
<210> 1419
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1419
ccucucuguc cccggcauuc 20
<210> 1420
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1420
ccucugaaau gccucuucuu 20
<210> 1421
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1421
ccucuggcca ggcauggcga 20
<210> 1422
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1422
ccucugggaa guggcaucau 20
<210> 1423
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1423
ccucuucuau gcaagccuug 20
<210> 1424
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1424
ccugaacuca agugauccag 20
<210> 1425
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1425
ccugaagucc cgucaaacga 20
<210> 1426
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1426
ccugaauguc uuacugugau 20
<210> 1427
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1427
ccugacagcc acaccugggu 20
<210> 1428
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1428
ccugacaucc ccuccccuuu 20
<210> 1429
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1429
ccugagacac ccgguuaccu 20
<210> 1430
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1430
ccugagaccu cgccggccuu 20
<210> 1431
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1431
ccugagcaac aaagcgagau 20
<210> 1432
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1432
ccugagucac uggucacccu 20
<210> 1433
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1433
ccugaguuua gggguuuggc 20
<210> 1434
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1434
ccugcaccca gguguggcug 20
<210> 1435
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1435
ccugccagag cuuuguuuua 20
<210> 1436
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1436
ccugcccaga acccuuccug 20
<210> 1437
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1437
ccugccccuc ucuguccccg 20
<210> 1438
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1438
ccugccucau ccaccaaucu 20
<210> 1439
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1439
ccuggagaga aauggaggug 20
<210> 1440
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1440
ccuggagucc cgucccugcc 20
<210> 1441
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1441
ccuggccaga ggccaugggc 20
<210> 1442
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1442
ccuggcccug ccucauccac 20
<210> 1443
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1443
ccuggccugg gaucccaucc 20
<210> 1444
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1444
ccuggcuguc uagcaaggcu 20
<210> 1445
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1445
ccuggcuuaa ggaagguaca 20
<210> 1446
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1446
ccugggaucc caucccaaca 20
<210> 1447
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1447
ccuggggaca auugccaauc 20
<210> 1448
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1448
ccugggugca ggccacgugu 20
<210> 1449
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1449
ccuggucccc ccgggccugu 20
<210> 1450
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1450
ccugguugcu guauuuguuc 20
<210> 1451
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1451
ccuguacaga uaguggggau 20
<210> 1452
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1452
ccugucaccc ccgaaucaug 20
<210> 1453
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1453
ccuguguagg ggguuauugc 20
<210> 1454
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1454
ccugugucug gccaaauuca 20
<210> 1455
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1455
ccuguucugc cucccagaug 20
<210> 1456
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1456
ccuguuucuc uuauccuuca 20
<210> 1457
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1457
ccuuaagcca ggaaagggau 20
<210> 1458
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1458
ccuucacgag gaaaggaaga 20
<210> 1459
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1459
ccuuccugag accucgccgg 20
<210> 1460
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1460
ccuuccuuaa gccaggaaag 20
<210> 1461
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1461
ccuucuauac agugguuuaa 20
<210> 1462
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1462
ccuugcuaga cagccagguu 20
<210> 1463
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1463
ccuugugaca ucuucacgcg 20
<210> 1464
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1464
ccuuguuuua uucaaagaca 20
<210> 1465
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1465
ccuuucaucu uccauguuug 20
<210> 1466
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1466
ccuuuccucg ugaaggauaa 20
<210> 1467
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1467
ccuuuccugg cuuaaggaag 20
<210> 1468
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1468
ccuuucuggu uucggagcac 20
<210> 1469
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1469
ccuuugcccu gucacccccg 20
<210> 1470
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1470
cgaaaccaga aaggcuuauc 20
<210> 1471
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1471
cgaaagacac uggguggguc 20
<210> 1472
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1472
cgaacuggac ugugugcaac 20
<210> 1473
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1473
cgaagccugu ucugccuccc 20
<210> 1474
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1474
cgaaucauga cccacccagu 20
<210> 1475
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1475
cgacaagauu ggggaaguga 20
<210> 1476
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1476
cgacaauggc aguucucgau 20
<210> 1477
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1477
cgacagaaaa cagugcaaaa 20
<210> 1478
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1478
cgacagccuc aaaugccuga 20
<210> 1479
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1479
cgaccccuac ccacuuccau 20
<210> 1480
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1480
cgacgccaug aaucccuuuc 20
<210> 1481
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1481
cgagaacugc cauugucguc 20
<210> 1482
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1482
cgagaauagu cacugaacaa 20
<210> 1483
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1483
cgagaccaaa cucauucacc 20
<210> 1484
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1484
cgagauccca ucucuacaaa 20
<210> 1485
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1485
cgaggaaagg aagaaaccaa 20
<210> 1486
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1486
cgaggugggu uuguaccuuc 20
<210> 1487
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1487
cgauauucac gaucacggcu 20
<210> 1488
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1488
cgaucacggc uuugaagucc 20
<210> 1489
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1489
cgauccagac uggaggauuu 20
<210> 1490
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1490
cgauuucaga aagaaccuga 20
<210> 1491
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1491
cgcauuuacg ugcuccgaaa 20
<210> 1492
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1492
cgccacguca uccuccagac 20
<210> 1493
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1493
cgccaugaau cccuuuccug 20
<210> 1494
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1494
cgccaugccu ggccagaggc 20
<210> 1495
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1495
cgcccaccua gugcuuccac 20
<210> 1496
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1496
cgcccggccu caccgugcau 20
<210> 1497
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1497
cgccggccuu guuuuauuca 20
<210> 1498
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1498
cgccguguua cuguugcacu 20
<210> 1499
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1499
cgcgggaguc ugacggaggc 20
<210> 1500
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1500
cgcgugaaga ugucacaagg 20
<210> 1501
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1501
cgcuuuguug cucaggccug 20
<210> 1502
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1502
cgcuuuuugg gagaaugaug 20
<210> 1503
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1503
cggaaaugau cuggcugaau 20
<210> 1504
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1504
cggacagugc ccaugcaaug 20
<210> 1505
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1505
cggacauaaa gacgacaaug 20
<210> 1506
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1506
cggacaucag ugcaacagua 20
<210> 1507
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1507
cggagagaca gugacagccu 20
<210> 1508
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1508
cggagcacgu aaaugcgucc 20
<210> 1509
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1509
cggaggcugu cacugucucu 20
<210> 1510
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1510
cggauucagc cagaucauuu 20
<210> 1511
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1511
cggcauucau ugacacgggc 20
<210> 1512
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1512
cggccaaggu aaccgggugu 20
<210> 1513
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1513
cggccucacc gugcauguuu 20
<210> 1514
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1514
cggccuuguu uuauucaaag 20
<210> 1515
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1515
cggcgauuuc agaaagaacc 20
<210> 1516
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1516
cggcuuugaa gucccgguca 20
<210> 1517
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1517
cgggaaugga aguggguagg 20
<210> 1518
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1518
cgggaccccc uggcccugcc 20
<210> 1519
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1519
cgggacucca ggcagauguu 20
<210> 1520
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1520
cgggacuuca aagccgugau 20
<210> 1521
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1521
cgggacuuca gguucuuucu 20
<210> 1522
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1522
cgggaggaug ggcaccaggc 20
<210> 1523
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1523
cgggagucug acggaggcug 20
<210> 1524
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1524
cgggccuguu ucucuuaucc 20
<210> 1525
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1525
cgggcuuucc cuggccuggg 20
<210> 1526
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1526
cggggacaga gaggggcagg 20
<210> 1527
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1527
cggggacauc auucucccaa 20
<210> 1528
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1528
cggggcccug uguagggggu 20
<210> 1529
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1529
cggggggacc aggaugacac 20
<210> 1530
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1530
cgggggugac agggcaaagg 20
<210> 1531
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1531
cgggugucuc aggcacuuaa 20
<210> 1532
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1532
cggucaaccu gccccucucu 20
<210> 1533
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1533
cggugaggcc gggcgcagug 20
<210> 1534
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1534
cggugccacc acggauucag 20
<210> 1535
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1535
cgguggagag aaacucaaaa 20
<210> 1536
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1536
cguaaaugcg ucccuguaca 20
<210> 1537
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1537
cguacccagc ugauuuuuaa 20
<210> 1538
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1538
cgucaaacga uccagacugg 20
<210> 1539
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1539
cgucagacuc ccgcgugaag 20
<210> 1540
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1540
cgucauccuc cagacugacc 20
<210> 1541
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1541
cgucccugcc cagaacccuu 20
<210> 1542
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1542
cgucccugua cagauagugg 20
<210> 1543
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1543
cgucggaaau gaucuggcug 20
<210> 1544
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1544
cgucuuuaug uccgcccacc 20
<210> 1545
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1545
cgugaacauc ugccuggagu 20
<210> 1546
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1546
cgugaagaug ucacaaggga 20
<210> 1547
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1547
cgugaaggau aagagaaaca 20
<210> 1548
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1548
cgugaauauc gagaacugcc 20
<210> 1549
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1549
cgugacacaa uccucaaaca 20
<210> 1550
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1550
cgugagcuau gauuaugcca 20
<210> 1551
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1551
cgugaggaca cguggccugc 20
<210> 1552
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1552
cgugaggcac cugugucugg 20
<210> 1553
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1553
cgugauaagc cuuucugguu 20
<210> 1554
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1554
cgugaucgug aauaucgaga 20
<210> 1555
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1555
cgugcaaaua aucuuuguac 20
<210> 1556
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1556
cgugcauguu uuaaacacau 20
<210> 1557
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1557
cgugccaccg uacccagcug 20
<210> 1558
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1558
cgugcuccga aaccagaaag 20
<210> 1559
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1559
cguggccugc acccaggugu 20
<210> 1560
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1560
cguggcguga acaucugccu 20
<210> 1561
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1561
cguggucucc uugcacuuuc 20
<210> 1562
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1562
cgugguggca ccgagaccaa 20
<210> 1563
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1563
cguguccuca cggccaaggu 20
<210> 1564
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1564
cguguguguu gggaugggau 20
<210> 1565
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1565
cguguuacug uugcacugau 20
<210> 1566
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1566
cguguuuacc ucuucuaugc 20
<210> 1567
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1567
cguugacucc ugaguuuagg 20
<210> 1568
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1568
cguugauggg uauguguuua 20
<210> 1569
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1569
cguugcacac aguccaguuc 20
<210> 1570
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1570
cguuggugcc aucugcuguu 20
<210> 1571
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1571
cguuguaugu augaguggcu 20
<210> 1572
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1572
cguuugacgg gacuucaggu 20
<210> 1573
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1573
cuaaacucag gagucaacgu 20
<210> 1574
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1574
cuaaccuggc ugucuagcaa 20
<210> 1575
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1575
cuaagccaaa ccccuaaacu 20
<210> 1576
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1576
cuacaaaaac cuucuauaca 20
<210> 1577
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1577
cuacacaggg ccccgagaau 20
<210> 1578
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1578
cuacccacuu ccauucccgu 20
<210> 1579
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1579
cuagacagcc agguuagccu 20
<210> 1580
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1580
cuagcaaggc uugcauagaa 20
<210> 1581
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1581
cuaggugggc ggacauaaag 20
<210> 1582
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1582
cuagugcuuc cacuucuaug 20
<210> 1583
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1583
cuauacagug guuuaaaaag 20
<210> 1584
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1584
cuaucuguac agggacgcau 20
<210> 1585
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1585
cuaugauuau gccacugcuu 20
<210> 1586
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1586
cuaugcaaau gccuccaagc 20
<210> 1587
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1587
cuaugcaagc cuugcuagac 20
<210> 1588
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1588
cuauucucgg ggcccugugu 20
<210> 1589
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1589
cuauuuauuu uugcaaaccc 20
<210> 1590
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1590
cucaaaacuu ccuggagaga 20
<210> 1591
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1591
cucaaacaug gaagaugaaa 20
<210> 1592
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1592
cucaaaugcc ugagcucaaa 20
<210> 1593
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1593
cucaagugau ccagcucagc 20
<210> 1594
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1594
cucaccgugc auguuuuaaa 20
<210> 1595
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1595
cucacgacag ccucaaaugc 20
<210> 1596
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1596
cucacggcca agguaaccgg 20
<210> 1597
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1597
cucagccucg ccaugccugg 20
<210> 1598
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1598
cucaggaagg guucugggca 20
<210> 1599
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1599
cucaggaguc aacguguuua 20
<210> 1600
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1600
cucaggcacu uaauaaauau 20
<210> 1601
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1601
cucaggcauu ugaggcuguc 20
<210> 1602
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1602
cucaggccug gucuccaacu 20
<210> 1603
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1603
cucaggcucu gccucuggga 20
<210> 1604
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1604
cucaguucag aguuguacac 20
<210> 1605
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1605
cucauacaua caacggggac 20
<210> 1606
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1606
cucauccacc aaucucuaag 20
<210> 1607
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1607
cuccaagcca uucacuuccc 20
<210> 1608
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1608
cuccaccgug acacaauccu 20
<210> 1609
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1609
cuccaggaag uuuugaguuu 20
<210> 1610
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1610
cuccaggcag auguucacgc 20
<210> 1611
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1611
cuccagucug gaucguuuga 20
<210> 1612
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1612
cuccauuucu cuccaggaag 20
<210> 1613
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1613
cucccaaaaa gcguugcaca 20
<210> 1614
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1614
cucccaccuc agccucgcca 20
<210> 1615
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1615
cucccagaag ccacucauac 20
<210> 1616
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1616
cuccccuuuc aucuuccaug 20
<210> 1617
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1617
cucccgaccc cuacccacuu 20
<210> 1618
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1618
cucccgcgug aagaugucac 20
<210> 1619
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1619
cuccgaaacc agaaaggcuu 20
<210> 1620
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1620
cuccggacau cagugcaaca 20
<210> 1621
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1621
cuccgucaga cucccgcgug 20
<210> 1622
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1622
cuccugaacu caagugaucc 20
<210> 1623
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1623
cuccugaguu uagggguuug 20
<210> 1624
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1624
cuccuugcac uuucucaguu 20
<210> 1625
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1625
cucgaaagac acuggguggg 20
<210> 1626
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1626
cucgauauuc acgaucacgg 20
<210> 1627
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1627
cucgaucaug gcucacugca 20
<210> 1628
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1628
cucgccaugc cuggccagag 20
<210> 1629
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1629
cucgccggcc uuguuuuauu 20
<210> 1630
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1630
cucgcuuugu ugcucaggcc 20
<210> 1631
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1631
cucggggccc uguguagggg 20
<210> 1632
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1632
cucggugcca ccacggauuc 20
<210> 1633
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1633
cucgugaagg auaagagaaa 20
<210> 1634
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1634
cucuaagcca aaccccuaaa 20
<210> 1635
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1635
cucuccaccg ugacacaauc 20
<210> 1636
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1636
cucuccagga aguuuugagu 20
<210> 1637
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1637
cucuccggac aucagugcaa 20
<210> 1638
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1638
cucucugucc ccggcauuca 20
<210> 1639
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1639
cucugaaaug ccucuucuuu 20
<210> 1640
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1640
cucugaacug agaaagugca 20
<210> 1641
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1641
cucugccucu gggaaguggc 20
<210> 1642
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1642
cucuggcagg caaugcuuug 20
<210> 1643
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1643
cucuggccag gcauggcgag 20
<210> 1644
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1644
cucugggaag uggcaucauu 20
<210> 1645
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1645
cucugggccu gacauccccu 20
<210> 1646
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1646
cucugucccc ggcauucauu 20
<210> 1647
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1647
cucugucuuu gaauaaaaca 20
<210> 1648
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1648
cucuuaaaaa augaauuugg 20
<210> 1649
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1649
cucuuauccu ucacgaggaa 20
<210> 1650
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1650
cucuucuaug caagccuugc 20
<210> 1651
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1651
cugaaauagg gucuucaucu 20
<210> 1652
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1652
cugaaaucgc cguguuacug 20
<210> 1653
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1653
cugaaaugcc ucuucuuuau 20
<210> 1654
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1654
cugaacaaau acagcaacca 20
<210> 1655
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1655
cugaacucaa gugauccagc 20
<210> 1656
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1656
cugaacugag aaagugcaag 20
<210> 1657
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1657
cugaaguccc gucaaacgau 20
<210> 1658
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1658
cugaauccgu gguggcaccg 20
<210> 1659
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1659
cugaaugucu uacugugauc 20
<210> 1660
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1660
cugacagcca caccugggug 20
<210> 1661
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1661
cugacauccc cuccccuuuc 20
<210> 1662
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1662
cugacggagg cugucacugu 20
<210> 1663
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1663
cugagaaagu gcaaggagac 20
<210> 1664
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1664
cugagacacc cgguuaccuu 20
<210> 1665
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1665
cugagaccuc gccggccuug 20
<210> 1666
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1666
cugagcaaca aagcgagauc 20
<210> 1667
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1667
cugagcugga ucacuugagu 20
<210> 1668
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1668
cugagucacu ggucacccuu 20
<210> 1669
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1669
cugaguuuag ggguuuggcu 20
<210> 1670
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1670
cugauguccg gagagacagu 20
<210> 1671
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1671
cugcacccag guguggcugu 20
<210> 1672
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1672
cugccagagc uuuguuuuau 20
<210> 1673
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1673
cugccauugu cgucuuuaug 20
<210> 1674
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1674
cugcccagaa cccuuccuga 20
<210> 1675
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1675
cugccccucu cuguccccgg 20
<210> 1676
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1676
cugccucauc caccaaucuc 20
<210> 1677
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1677
cugccuccca gaugaauaaa 20
<210> 1678
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1678
cugccucugg gaaguggcau 20
<210> 1679
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1679
cugccuggag ucccgucccu 20
<210> 1680
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1680
cugcgcccgg ccucaccgug 20
<210> 1681
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1681
cugcugaugc accaugcaug 20
<210> 1682
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1682
cugcuguugu guguugaaag 20
<210> 1683
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1683
cugcuuucca gccugggcaa 20
<210> 1684
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1684
cuggaaagca guggcauaau 20
<210> 1685
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1685
cuggacugug ugcaacgcuu 20
<210> 1686
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1686
cuggagagaa auggaggugu 20
<210> 1687
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1687
cuggaggaug acguggcgug 20
<210> 1688
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1688
cuggaguccc gucccugccc 20
<210> 1689
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1689
cuggaucacu ugaguucagg 20
<210> 1690
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1690
cuggaucguu ugacgggacu 20
<210> 1691
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1691
cuggcaggca augcuuuggu 20
<210> 1692
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1692
cuggccaaau ucauuuuuua 20
<210> 1693
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1693
cuggccagag gccaugggcu 20
<210> 1694
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1694
cuggccaggc auggcgaggc 20
<210> 1695
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1695
cuggcccugc cucauccacc 20
<210> 1696
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1696
cuggccuggg aucccauccc 20
<210> 1697
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1697
cuggcugaau ccgugguggc 20
<210> 1698
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1698
cuggcugucu agcaaggcuu 20
<210> 1699
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1699
cuggcuuaag gaagguacaa 20
<210> 1700
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1700
cugggaagug gcaucauuug 20
<210> 1701
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1701
cugggagaug ggugucacuu 20
<210> 1702
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1702
cugggaggca gaacaggcuu 20
<210> 1703
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1703
cugggauccc aucccaacac 20
<210> 1704
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1704
cugggcaggg acgggacucc 20
<210> 1705
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1705
cugggccuga cauccccucc 20
<210> 1706
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1706
cuggggacaa uugccaaucc 20
<210> 1707
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1707
cuggguacgg uggcacgugc 20
<210> 1708
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1708
cugggugcag gccacguguc 20
<210> 1709
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1709
cugggugggu caugauucgg 20
<210> 1710
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1710
cuggucaccc uuaauauuua 20
<210> 1711
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1711
cugguccccc cgggccuguu 20
<210> 1712
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1712
cuggugccca uccucccgac 20
<210> 1713
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1713
cugguguccu gacagccaca 20
<210> 1714
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1714
cugguugcug uauuuguuca 20
<210> 1715
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1715
cugguuucgg agcacguaaa 20
<210> 1716
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1716
cuguacagau aguggggauu 20
<210> 1717
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1717
cuguacaggg acgcauuuac 20
<210> 1718
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1718
cuguauagaa gguuuuugua 20
<210> 1719
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1719
cuguauuugu ucagugacua 20
<210> 1720
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1720
cugucacccc cgaaucauga 20
<210> 1721
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1721
cugucacugu cucuccggac 20
<210> 1722
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1722
cugucaggac accagccugg 20
<210> 1723
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1723
cuguccccgg cauucauuga 20
<210> 1724
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1724
cuguccgaag ccuguucugc 20
<210> 1725
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1725
cugucuagca aggcuugcau 20
<210> 1726
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1726
cugucucucc ggacaucagu 20
<210> 1727
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1727
cugucuuuga auaaaacaag 20
<210> 1728
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1728
cuguguaggg gguuauugcc 20
<210> 1729
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1729
cugugucugg ccaaauucau 20
<210> 1730
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1730
cugugugcaa cgcuuuuugg 20
<210> 1731
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1731
cuguucugcc ucccagauga 20
<210> 1732
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1732
cuguugcacu gauguccgga 20
<210> 1733
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1733
cuguugugug uugaaagcca 20
<210> 1734
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1734
cuguuucucu uauccuucac 20
<210> 1735
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1735
cuguuuucug ucgugugugu 20
<210> 1736
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1736
cuuaaaaaau gaauuuggcc 20
<210> 1737
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1737
cuuaagccag gaaagggauu 20
<210> 1738
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1738
cuuaaggaag guacaaaccc 20
<210> 1739
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1739
cuuaauaaau auuaagggug 20
<210> 1740
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1740
cuuaauauuu auuaagugcc 20
<210> 1741
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1741
cuuagagauu gguggaugag 20
<210> 1742
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1742
cuuaucacgg uucccugcac 20
<210> 1743
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1743
cuuauccuuc acgaggaaag 20
<210> 1744
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1744
cuucaaagcc gugaucguga 20
<210> 1745
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1745
cuucacgagg aaaggaagaa 20
<210> 1746
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1746
cuucacgcgg gagucugacg 20
<210> 1747
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1747
cuucagguuc uuucugaaau 20
<210> 1748
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1748
cuuccacuuc uaugcaaaug 20
<210> 1749
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1749
cuuccauguu ugaggauugu 20
<210> 1750
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1750
cuucccagag gcagagccug 20
<210> 1751
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1751
cuuccccaau cuugucguug 20
<210> 1752
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1752
cuuccugaga ccucgccggc 20
<210> 1753
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1753
cuuccuggag agaaauggag 20
<210> 1754
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1754
cuuccuuaag ccaggaaagg 20
<210> 1755
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1755
cuuccuuucc ucgugaagga 20
<210> 1756
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1756
cuucggacag ugcccaugca 20
<210> 1757
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1757
cuucuauaca gugguuuaaa 20
<210> 1758
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1758
cuucuaugca aaugccucca 20
<210> 1759
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1759
cuucuaugca agccuugcua 20
<210> 1760
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1760
cuucucuggg ccugacaucc 20
<210> 1761
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1761
cuucucuguc uuugaauaaa 20
<210> 1762
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1762
cuucugggag auggguguca 20
<210> 1763
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1763
cuugcacuuu cucaguucag 20
<210> 1764
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1764
cuugcauaga agagguaaac 20
<210> 1765
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1765
cuugcuagac agccagguua 20
<210> 1766
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1766
cuugcuucuc ugggccugac 20
<210> 1767
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1767
cuuggaggca uuugcauaga 20
<210> 1768
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1768
cuuggccgug aggacacgug 20
<210> 1769
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1769
cuuggguugg gauuuugguu 20
<210> 1770
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1770
cuugucguug auggguaugu 20
<210> 1771
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1771
cuugugacau cuucacgcgg 20
<210> 1772
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1772
cuuguuuuau ucaaagacag 20
<210> 1773
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1773
cuuuauguac aaagauuauu 20
<210> 1774
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1774
cuuuaugucc gcccaccuag 20
<210> 1775
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1775
cuuucaacac acaacagcag 20
<210> 1776
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1776
cuuucaucuu ccauguuuga 20
<210> 1777
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1777
cuuucccugg ccugggaucc 20
<210> 1778
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1778
cuuuccucgu gaaggauaag 20
<210> 1779
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1779
cuuuccuggc uuaaggaagg 20
<210> 1780
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1780
cuuucgaggu ggguuuguac 20
<210> 1781
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1781
cuuucucagu ucagaguugu 20
<210> 1782
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1782
cuuucugaaa ucgccguguu 20
<210> 1783
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1783
cuuucugguu ucggagcacg 20
<210> 1784
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1784
cuuugaaguc ccggucaacc 20
<210> 1785
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1785
cuuugaauaa aacaaggccg 20
<210> 1786
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1786
cuuugcccug ucacccccga 20
<210> 1787
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1787
cuuugggagg cugagcugga 20
<210> 1788
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1788
cuuuggucuu cucugucuuu 20
<210> 1789
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1789
cuuuguacau aaagaagagg 20
<210> 1790
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1790
cuuuguugcu caggccuggu 20
<210> 1791
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1791
cuuuuuaaac cacuguauag 20
<210> 1792
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1792
cuuuuuggga gaaugauguc 20
<210> 1793
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1793
cuuuuugguu uuuguagaga 20
<210> 1794
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1794
gaaacaggcc cggggggacc 20
<210> 1795
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1795
gaaaccaaaa ucccaaccca 20
<210> 1796
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1796
gaaaccagaa aggcuuauca 20
<210> 1797
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1797
gaaacucaaa acuuccugga 20
<210> 1798
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1798
gaaagaaccu gaagucccgu 20
<210> 1799
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1799
gaaagacacu ggguggguca 20
<210> 1800
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1800
gaaagcagug gcauaaucau 20
<210> 1801
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1801
gaaagccacu ugcuucucug 20
<210> 1802
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1802
gaaagcccgu gucaaugaau 20
<210> 1803
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1803
gaaaggaaga aaccaaaauc 20
<210> 1804
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1804
gaaaggcuua ucacgguucc 20
<210> 1805
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1805
gaaagggauu cauggcgucg 20
<210> 1806
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1806
gaaaggggag gggaugucag 20
<210> 1807
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1807
gaaagugcaa ggagaccacg 20
<210> 1808
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1808
gaaaucgccg uguuacuguu 20
<210> 1809
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1809
gaaaugaucu ggcugaaucc 20
<210> 1810
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1810
gaaaugccuc uucuuuaugu 20
<210> 1811
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1811
gaaauggagg ugucauccug 20
<210> 1812
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1812
gaacaaauac agcaaccagg 20
<210> 1813
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1813
gaacaggcuu cggacagugc 20
<210> 1814
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1814
gaacaucugc cuggaguccc 20
<210> 1815
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1815
gaacccuucc ugagaccucg 20
<210> 1816
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1816
gaaccgugau aagccuuucu 20
<210> 1817
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1817
gaaccugaag ucccgucaaa 20
<210> 1818
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1818
gaacucaagu gauccagcuc 20
<210> 1819
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1819
gaacugagaa agugcaagga 20
<210> 1820
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1820
gaacugccau ugucgucuuu 20
<210> 1821
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1821
gaacuggacu gugugcaacg 20
<210> 1822
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1822
gaagaaacca aaaucccaac 20
<210> 1823
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1823
gaagaccaaa gcauugccug 20
<210> 1824
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1824
gaagacccua uuucagaaau 20
<210> 1825
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1825
gaagaggcau uucagaggca 20
<210> 1826
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1826
gaagagguaa acacguugac 20
<210> 1827
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1827
gaagaugaaa ggggagggga 20
<210> 1828
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1828
gaagauguca caagggauug 20
<210> 1829
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1829
gaagcaagug gcuuucaaca 20
<210> 1830
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1830
gaagcacuag gugggcggac 20
<210> 1831
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1831
gaagccacuc auacauacaa 20
<210> 1832
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1832
gaagccuguu cugccuccca 20
<210> 1833
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1833
gaaggauaag agaaacaggc 20
<210> 1834
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1834
gaaggguucu gggcagggac 20
<210> 1835
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1835
gaagguacaa acccaccucg 20
<210> 1836
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1836
gaagguuuuu guagccugaa 20
<210> 1837
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1837
gaagucccgg ucaaccugcc 20
<210> 1838
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1838
gaagucccgu caaacgaucc 20
<210> 1839
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1839
gaagugaaug gcuuggaggc 20
<210> 1840
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1840
gaaguggaag cacuaggugg 20
<210> 1841
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1841
gaaguggcau cauuugguga 20
<210> 1842
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1842
gaagugggua ggggucggga 20
<210> 1843
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1843
gaaguuuuga guuucucucc 20
<210> 1844
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1844
gaauaaaaca aggccggcga 20
<210> 1845
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1845
gaauagucac ugaacaaaua 20
<210> 1846
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1846
gaauaucgag aacugccauu 20
<210> 1847
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1847
gaaucaugac ccacccagug 20
<210> 1848
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1848
gaaucccuuu ccuggcuuaa 20
<210> 1849
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1849
gaauccgugg uggcaccgag 20
<210> 1850
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1850
gaaugaguuu ggucucggug 20
<210> 1851
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1851
gaaugauguc cccguuguau 20
<210> 1852
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1852
gaaugccggg gacagagagg 20
<210> 1853
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1853
gaauggaagu ggguaggggu 20
<210> 1854
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1854
gaauggcuug gaggcauuug 20
<210> 1855
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1855
gaauuuggcc agacacaggu 20
<210> 1856
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1856
gacaagauug gggaagugaa 20
<210> 1857
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1857
gacaauggca guucucgaua 20
<210> 1858
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1858
gacaauugcc aaucccuugu 20
<210> 1859
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1859
gacacaaucc ucaaacaugg 20
<210> 1860
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1860
gacacaggug ccucacgccu 20
<210> 1861
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1861
gacacagugu uuugucccug 20
<210> 1862
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1862
gacaccagcc uggugcccau 20
<210> 1863
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1863
gacacccauc ucccagaagc 20
<210> 1864
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1864
gacaccucca uuucucucca 20
<210> 1865
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1865
gacacgggcu uucccuggcc 20
<210> 1866
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1866
gacacguggc cugcacccag 20
<210> 1867
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1867
gacacugggu gggucaugau 20
<210> 1868
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1868
gacagaaaac agugcaaaau 20
<210> 1869
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1869
gacagagaag accaaagcau 20
<210> 1870
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1870
gacagagagg ggcagguuga 20
<210> 1871
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1871
gacagauggu cagucuggag 20
<210> 1872
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1872
gacagccaca ccugggugca 20
<210> 1873
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1873
gacagccagg uuagccuuug 20
<210> 1874
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1874
gacagccuca aaugccugag 20
<210> 1875
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1875
gacagccucc gucagacucc 20
<210> 1876
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1876
gacagggcaa aggcuaaccu 20
<210> 1877
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1877
gacagugaca gccuccguca 20
<210> 1878
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1878
gacagugccc augcaauggc 20
<210> 1879
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1879
gacauaaaga cgacaauggc 20
<210> 1880
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1880
gacaucagug caacaguaac 20
<210> 1881
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1881
gacaucauuc ucccaaaaag 20
<210> 1882
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1882
gacauccccu ccccuuucau 20
<210> 1883
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1883
gacaucuuca cgcgggaguc 20
<210> 1884
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1884
gacauucagg cuacaaaaac 20
<210> 1885
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1885
gaccaaacuc auucaccaaa 20
<210> 1886
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1886
gaccaaagca uugccugcca 20
<210> 1887
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1887
gaccacggga auggaagugg 20
<210> 1888
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1888
gaccaggaug acaccuccau 20
<210> 1889
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1889
gaccaggccu gagcaacaaa 20
<210> 1890
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1890
gaccagugac ucaggcucug 20
<210> 1891
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1891
gacccaccca gugucuuucg 20
<210> 1892
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1892
gaccccaucu cuuaaaaaau 20
<210> 1893
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1893
gacccccugg cccugccuca 20
<210> 1894
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1894
gacccuauuu cagaaauaca 20
<210> 1895
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1895
gaccgggacu ucaaagccgu 20
<210> 1896
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1896
gaccucgccg gccuuguuuu 20
<210> 1897
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1897
gacgcauuua cgugcuccga 20
<210> 1898
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1898
gacgccauga aucccuuucc 20
<210> 1899
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1899
gacggaggcu gucacugucu 20
<210> 1900
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1900
gacgggacuc caggcagaug 20
<210> 1901
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1901
gacgggacuu cagguucuuu 20
<210> 1902
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1902
gacguggcgu gaacaucugc 20
<210> 1903
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1903
gacuauucuc ggggcccugu 20
<210> 1904
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1904
gacucaggcu cugccucugg 20
<210> 1905
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1905
gacuccaggc agauguucac 20
<210> 1906
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1906
gacucccgcg ugaagauguc 20
<210> 1907
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1907
gacuccugag uuuagggguu 20
<210> 1908
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1908
gacugugugc aacgcuuuuu 20
<210> 1909
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1909
gacuucaaag ccgugaucgu 20
<210> 1910
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1910
gacuucaggu ucuuucugaa 20
<210> 1911
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1911
gagaaacagg cccgggggga 20
<210> 1912
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1912
gagaaacuca aaacuuccug 20
<210> 1913
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1913
gagaaagugc aaggagacca 20
<210> 1914
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1914
gagaaaugga ggugucaucc 20
<210> 1915
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1915
gagaacugcc auugucgucu 20
<210> 1916
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1916
gagaagacca aagcauugcc 20
<210> 1917
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1917
gagaagcaag uggcuuucaa 20
<210> 1918
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1918
gagaauaguc acugaacaaa 20
<210> 1919
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1919
gagaaugaug uccccguugu 20
<210> 1920
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1920
gagacacccg guuaccuugg 20
<210> 1921
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1921
gagacagaug gucagucugg 20
<210> 1922
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1922
gagacaguga cagccuccgu 20
<210> 1923
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1923
gagaccaaac ucauucacca 20
<210> 1924
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1924
gagaccacgg gaauggaagu 20
<210> 1925
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1925
gagaccaggc cugagcaaca 20
<210> 1926
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1926
gagaccucgc cggccuuguu 20
<210> 1927
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1927
gagagaaacu caaaacuucc 20
<210> 1928
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1928
gagagaaaug gaggugucau 20
<210> 1929
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1929
gagagacagu gacagccucc 20
<210> 1930
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1930
gagaggggca gguugaccgg 20
<210> 1931
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1931
gagaugggau cucgcuuugu 20
<210> 1932
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1932
gagaugggug ucacuuuuua 20
<210> 1933
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1933
gagauuggug gaugaggcag 20
<210> 1934
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1934
gagcaacaaa gcgagauccc 20
<210> 1935
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1935
gagcacguaa augcgucccu 20
<210> 1936
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1936
gagccugagu cacuggucac 20
<210> 1937
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1937
gagcuaugau uaugccacug 20
<210> 1938
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1938
gagcucaggc auuugaggcu 20
<210> 1939
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1939
gagcuggauc acuugaguuc 20
<210> 1940
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1940
gaggaaagga agaaaccaaa 20
<210> 1941
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1941
gaggacacgu ggccugcacc 20
<210> 1942
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1942
gaggaugacg uggcgugaac 20
<210> 1943
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1943
gaggaugggc accaggcugg 20
<210> 1944
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1944
gaggaugguu ugagcucagg 20
<210> 1945
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1945
gaggauugug ucacggugga 20
<210> 1946
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1946
gaggcaauaa cccccuacac 20
<210> 1947
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1947
gaggcaccug ugucuggcca 20
<210> 1948
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1948
gaggcagaac aggcuucgga 20
<210> 1949
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1949
gaggcagagc cugagucacu 20
<210> 1950
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1950
gaggcagggc cagggggucc 20
<210> 1951
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1951
gaggcauuuc agaggcaaua 20
<210> 1952
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1952
gaggcauuug cauagaagug 20
<210> 1953
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1953
gaggccaugg gcugcugaug 20
<210> 1954
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1954
gaggcugagc uggaucacuu 20
<210> 1955
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1955
gaggcuguca cugucucucc 20
<210> 1956
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1956
gaggggaugu caggcccaga 20
<210> 1957
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1957
gaggggcagg uugaccggga 20
<210> 1958
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1958
gagguaaaca cguugacucc 20
<210> 1959
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1959
gaggucucag gaaggguucu 20
<210> 1960
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1960
gagguggguu uguaccuucc 20
<210> 1961
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1961
gaggugucau ccuggucccc 20
<210> 1962
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1962
gagucaacgu guuuaccucu 20
<210> 1963
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1963
gagucacugg ucacccuuaa 20
<210> 1964
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1964
gagucccguc ccugcccaga 20
<210> 1965
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1965
gagucugacg gaggcuguca 20
<210> 1966
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1966
gaguggcuuc ugggagaugg 20
<210> 1967
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1967
gaguucagga guuggagacc 20
<210> 1968
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1968
gaguuggaga ccaggccuga 20
<210> 1969
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1969
gaguuguaca cuguguacau 20
<210> 1970
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1970
gaguuuaggg guuuggcuua 20
<210> 1971
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1971
gaguuugguc ucggugccac 20
<210> 1972
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1972
gauaagagaa acaggcccgg 20
<210> 1973
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1973
gauaagccuu ucugguuucg 20
<210> 1974
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1974
gauagugggg auuuuuuguu 20
<210> 1975
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1975
gauauucacg aucacggcuu 20
<210> 1976
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1976
gaucacaggc acgugccacc 20
<210> 1977
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1977
gaucacagua agacauucag 20
<210> 1978
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1978
gaucacggcu uugaaguccc 20
<210> 1979
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1979
gaucauuucc gacgccauga 20
<210> 1980
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1980
gauccagacu ggaggauuua 20
<210> 1981
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1981
gauccagcuc agccucccaa 20
<210> 1982
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1982
gaucccaggc cagggaaagc 20
<210> 1983
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1983
gaucccaucc caacacacac 20
<210> 1984
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1984
gaucccaucu cuacaaaaac 20
<210> 1985
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1985
gaucgugaau aucgagaacu 20
<210> 1986
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1986
gaucguuuga cgggacuuca 20
<210> 1987
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1987
gaucuggcug aauccguggu 20
<210> 1988
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1988
gaugaaaggg gaggggaugu 20
<210> 1989
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1989
gaugaagacc cuauuucaga 20
<210> 1990
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1990
gaugacaccu ccauuucucu 20
<210> 1991
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1991
gaugacgugg cgugaacauc 20
<210> 1992
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1992
gaugaggcag ggccaggggg 20
<210> 1993
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1993
gaugccacuu cccagaggca 20
<210> 1994
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1994
gauggcacca acgggacccc 20
<210> 1995
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1995
gaugggaucc caggccaggg 20
<210> 1996
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1996
gaugggaucu cgcuuuguug 20
<210> 1997
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1997
gaugggcacc aggcuggugu 20
<210> 1998
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1998
gauggguaug uguuuaaaac 20
<210> 1999
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 1999
gauggguguc acuuuuuaaa 20
<210> 2000
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2000
gauggucagu cuggaggaug 20
<210> 2001
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2001
gaugguuuga gcucaggcau 20
<210> 2002
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2002
gaugucacaa gggauuggca 20
<210> 2003
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2003
gaugucaggc ccagagaagc 20
<210> 2004
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2004
gauguccccg uuguauguau 20
<210> 2005
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2005
gauguccgga gagacaguga 20
<210> 2006
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2006
gauguucacg ccacgucauc 20
<210> 2007
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2007
gauuacaggc gugaggcacc 20
<210> 2008
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2008
gauuaugcca cugcuuucca 20
<210> 2009
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2009
gauuauuugc acgaacugga 20
<210> 2010
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2010
gauucagcca gaucauuucc 20
<210> 2011
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2011
gauucauggc gucggaaaug 20
<210> 2012
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2012
gauucggggg ugacagggca 20
<210> 2013
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2013
gauuggcaau uguccccagg 20
<210> 2014
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2014
gauuggggaa gugaauggcu 20
<210> 2015
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2015
gauuggugga ugaggcaggg 20
<210> 2016
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2016
gauuguguca cgguggagag 20
<210> 2017
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2017
gauuucagaa agaaccugaa 20
<210> 2018
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2018
gauuuugguu ucuuccuuuc 20
<210> 2019
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2019
gcaaacauaa caaaaaaucc 20
<210> 2020
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2020
gcaaacccug guugcuguau 20
<210> 2021
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2021
gcaaaggcua accuggcugu 20
<210> 2022
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2022
gcaaaugccu ccaagccauu 20
<210> 2023
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2023
gcaacagaug aagacccuau 20
<210> 2024
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2024
gcaacaguaa cacggcgauu 20
<210> 2025
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2025
gcaaccaggg uuugcaaaaa 20
<210> 2026
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2026
gcaacgcuuu uugggagaau 20
<210> 2027
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2027
gcaagccuug cuagacagcc 20
<210> 2028
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2028
gcaaggagac cacgggaaug 20
<210> 2029
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2029
gcaaggcuug cauagaagag 20
<210> 2030
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2030
gcaaguggcu uucaacacac 20
<210> 2031
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2031
gcaauaaccc ccuacacagg 20
<210> 2032
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2032
gcaaugcuuu ggucuucucu 20
<210> 2033
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2033
gcaauggcuu ggguugggau 20
<210> 2034
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2034
gcaauugucc ccagggacaa 20
<210> 2035
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2035
gcacacaguc caguucgugc 20
<210> 2036
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2036
gcaccaacgg gacccccugg 20
<210> 2037
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2037
gcaccaggcu gguguccuga 20
<210> 2038
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2038
gcacccaggu guggcuguca 20
<210> 2039
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2039
gcaccgagac caaacucauu 20
<210> 2040
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2040
gcaccugugu cuggccaaau 20
<210> 2041
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2041
gcacgaacug gacugugugc 20
<210> 2042
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2042
gcacggugag gccgggcgca 20
<210> 2043
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2043
gcacguaaau gcgucccugu 20
<210> 2044
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2044
gcacgugcca ccguacccag 20
<210> 2045
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2045
gcacuaggug ggcggacaua 20
<210> 2046
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2046
gcacugaugu ccggagagac 20
<210> 2047
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2047
gcacuguccg aagccuguuc 20
<210> 2048
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2048
gcacuguuuu cugucgugug 20
<210> 2049
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2049
gcacuuaaua aauauuaagg 20
<210> 2050
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2050
gcacuuucuc aguucagagu 20
<210> 2051
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2051
gcacuuuggg aggcugagcu 20
<210> 2052
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2052
gcacuuugua uauugguuga 20
<210> 2053
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2053
gcagaacagg cuucggacag 20
<210> 2054
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2054
gcagagccug agucacuggu 20
<210> 2055
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2055
gcagauggca ccaacgggac 20
<210> 2056
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2056
gcagauguuc acgccacguc 20
<210> 2057
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2057
gcagcccaug gccucuggcc 20
<210> 2058
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2058
gcaggcaaug cuuuggucuu 20
<210> 2059
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2059
gcaggccacg uguccucacg 20
<210> 2060
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2060
gcagggaacc gugauaagcc 20
<210> 2061
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2061
gcagggacgg gacuccaggc 20
<210> 2062
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2062
gcagggccag ggggucccgu 20
<210> 2063
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2063
gcagguugac cgggacuuca 20
<210> 2064
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2064
gcaguggcau aaucauagcu 20
<210> 2065
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2065
gcaguucucg auauucacga 20
<210> 2066
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2066
gcauagaaga gguaaacacg 20
<210> 2067
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2067
gcauagaagu ggaagcacua 20
<210> 2068
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2068
gcaucagcag cccauggccu 20
<210> 2069
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2069
gcaucauuug gugaaugagu 20
<210> 2070
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2070
gcauggcgag gcugaggugg 20
<210> 2071
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2071
gcaugggcac uguccgaagc 20
<210> 2072
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2072
gcauggugca ucagcagccc 20
<210> 2073
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2073
gcauguuuua aacacauacc 20
<210> 2074
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2074
gcauucauug acacgggcuu 20
<210> 2075
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2075
gcauugccug ccagagcuuu 20
<210> 2076
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2076
gcauuuacgu gcuccgaaac 20
<210> 2077
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2077
gcauuucaga ggcaauaacc 20
<210> 2078
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2078
gcauuugagg cugucgugag 20
<210> 2079
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2079
gcauuugcau agaaguggaa 20
<210> 2080
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2080
gcauuugugu uauuauuuug 20
<210> 2081
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2081
gccaaacccc uaaacucagg 20
<210> 2082
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2082
gccaaaugua cacaguguac 20
<210> 2083
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2083
gccaaauuca uuuuuuaaga 20
<210> 2084
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2084
gccaagguaa ccgggugucu 20
<210> 2085
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2085
gccaaucccu ugugacaucu 20
<210> 2086
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2086
gccacaccug ggugcaggcc 20
<210> 2087
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2087
gccaccacgg auucagccag 20
<210> 2088
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2088
gccaccguac ccagcugauu 20
<210> 2089
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2089
gccacgucau ccuccagacu 20
<210> 2090
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2090
gccacguguc cucacggcca 20
<210> 2091
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2091
gccacucaua cauacaacgg 20
<210> 2092
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2092
gccacugcgc ccggccucac 20
<210> 2093
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2093
gccacuuccc agaggcagag 20
<210> 2094
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2094
gccacuugcu ucucugggcc 20
<210> 2095
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2095
gccagacaca ggugccucac 20
<210> 2096
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2096
gccagaggcc augggcugcu 20
<210> 2097
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2097
gccagaucau uuccgacgcc 20
<210> 2098
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2098
gccaggaaag ggauucaugg 20
<210> 2099
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2099
gccaggcaug gcgaggcuga 20
<210> 2100
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2100
gccagggaaa gcccguguca 20
<210> 2101
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2101
gccagggggu cccguuggug 20
<210> 2102
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2102
gccagguuag ccuuugcccu 20
<210> 2103
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2103
gccaucugcu guuguguguu 20
<210> 2104
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2104
gccaugaauc ccuuuccugg 20
<210> 2105
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2105
gccaugccug gccagaggcc 20
<210> 2106
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2106
gccaugggcu gcugaugcac 20
<210> 2107
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2107
gccauucacu uccccaaucu 20
<210> 2108
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2108
gccauugcau gggcacuguc 20
<210> 2109
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2109
gcccaccuag ugcuuccacu 20
<210> 2110
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2110
gcccagaacc cuuccugaga 20
<210> 2111
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2111
gcccagagaa gcaaguggcu 20
<210> 2112
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2112
gcccaggcug gaaagcagug 20
<210> 2113
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2113
gcccaugcaa uggcuugggu 20
<210> 2114
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2114
gcccauggcc ucuggccagg 20
<210> 2115
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2115
gccccgagaa uagucacuga 20
<210> 2116
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2116
gccccucucu guccccggca 20
<210> 2117
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2117
gcccggccuc accgugcaug 20
<210> 2118
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2118
gcccgggggg accaggauga 20
<210> 2119
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2119
gcccguguca augaaugccg 20
<210> 2120
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2120
gcccugccuc auccaccaau 20
<210> 2121
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2121
gcccugucac ccccgaauca 20
<210> 2122
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2122
gcccugugua ggggguuauu 20
<210> 2123
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2123
gccggccuug uuuuauucaa 20
<210> 2124
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2124
gccggcgagg ucucaggaag 20
<210> 2125
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2125
gccggggaca gagaggggca 20
<210> 2126
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2126
gccgugagga cacguggccu 20
<210> 2127
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2127
gccgugaucg ugaauaucga 20
<210> 2128
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2128
gccguguuac uguugcacug 20
<210> 2129
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2129
gccucaaaug ccugagcuca 20
<210> 2130
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2130
gccucaucca ccaaucucua 20
<210> 2131
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2131
gccuccaagc cauucacuuc 20
<210> 2132
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2132
gccucccaga ugaauaaaua 20
<210> 2133
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2133
gccuccguca gacucccgcg 20
<210> 2134
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2134
gccucgccau gccuggccag 20
<210> 2135
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2135
gccucugaaa ugccucuucu 20
<210> 2136
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2136
gccucuggcc aggcauggcg 20
<210> 2137
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2137
gccucuggga aguggcauca 20
<210> 2138
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2138
gccucuucuu uauguacaaa 20
<210> 2139
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2139
gccugaaugu cuuacuguga 20
<210> 2140
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2140
gccugacauc cccuccccuu 20
<210> 2141
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2141
gccugagcaa caaagcgaga 20
<210> 2142
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2142
gccugagcuc aaaccauccu 20
<210> 2143
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2143
gccugaguca cuggucaccc 20
<210> 2144
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2144
gccugcaccc agguguggcu 20
<210> 2145
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2145
gccugccaga gcuuuguuuu 20
<210> 2146
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2146
gccuggaguc ccgucccugc 20
<210> 2147
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2147
gccuggccag aggccauggg 20
<210> 2148
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2148
gccugggauc ccaucccaac 20
<210> 2149
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2149
gccuggugcc cauccucccg 20
<210> 2150
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2150
gccuguucug ccucccagau 20
<210> 2151
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2151
gccuguuucu cuuauccuuc 20
<210> 2152
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2152
gccuugcuag acagccaggu 20
<210> 2153
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2153
gccuuguuuu auucaaagac 20
<210> 2154
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2154
gccuuucugg uuucggagca 20
<210> 2155
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2155
gccuuugccc ugucaccccc 20
<210> 2156
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2156
gcgagauccc aucucuacaa 20
<210> 2157
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2157
gcgaggucuc aggaaggguu 20
<210> 2158
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2158
gcgauuucag aaagaaccug 20
<210> 2159
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2159
gcgcccggcc ucaccgugca 20
<210> 2160
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2160
gcggacauaa agacgacaau 20
<210> 2161
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2161
gcgggagucu gacggaggcu 20
<210> 2162
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2162
gcgucccugu acagauagug 20
<210> 2163
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2163
gcgucggaaa ugaucuggcu 20
<210> 2164
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2164
gcgugaacau cugccuggag 20
<210> 2165
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2165
gcgugaagau gucacaaggg 20
<210> 2166
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2166
gcgugaggca ccugugucug 20
<210> 2167
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2167
gcguugcaca caguccaguu 20
<210> 2168
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2168
gcuaaccugg cugucuagca 20
<210> 2169
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2169
gcuacaaaaa ccuucuauac 20
<210> 2170
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2170
gcuagacagc cagguuagcc 20
<210> 2171
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2171
gcuaugauua ugccacugcu 20
<210> 2172
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2172
gcucacgaca gccucaaaug 20
<210> 2173
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2173
gcucaggcau uugaggcugu 20
<210> 2174
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2174
gcucaggccu ggucuccaac 20
<210> 2175
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2175
gcucugccuc ugggaagugg 20
<210> 2176
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2176
gcucuggcag gcaaugcuuu 20
<210> 2177
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2177
gcugaauccg ugguggcacc 20
<210> 2178
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2178
gcugagcugg aucacuugag 20
<210> 2179
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2179
gcugcugaug caccaugcau 20
<210> 2180
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2180
gcuggaaagc aguggcauaa 20
<210> 2181
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2181
gcuggaucac uugaguucag 20
<210> 2182
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2182
gcuggguacg guggcacgug 20
<210> 2183
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2183
gcuggugucc ugacagccac 20
<210> 2184
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2184
gcuguauuug uucagugacu 20
<210> 2185
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2185
gcugucacug ucucuccgga 20
<210> 2186
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2186
gcugucagga caccagccug 20
<210> 2187
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2187
gcugucuagc aaggcuugca 20
<210> 2188
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2188
gcuguugugu guugaaagcc 20
<210> 2189
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2189
gcuuaaggaa gguacaaacc 20
<210> 2190
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2190
gcuuagagau ugguggauga 20
<210> 2191
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2191
gcuuaucacg guucccugca 20
<210> 2192
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2192
gcuuccacuu cuaugcaaau 20
<210> 2193
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2193
gcuucggaca gugcccaugc 20
<210> 2194
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2194
gcuucucugg gccugacauc 20
<210> 2195
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2195
gcuucuggga gauggguguc 20
<210> 2196
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2196
gcuugcauag aagagguaaa 20
<210> 2197
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2197
gcuuggaggc auuugcauag 20
<210> 2198
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2198
gcuuggguug ggauuuuggu 20
<210> 2199
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2199
gcuuucaaca cacaacagca 20
<210> 2200
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2200
gcuuuccagc cugggcaaca 20
<210> 2201
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2201
gcuuucccug gccugggauc 20
<210> 2202
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2202
gcuuugaagu cccggucaac 20
<210> 2203
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2203
gcuuuggucu ucucugucuu 20
<210> 2204
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2204
gcuuuguugc ucaggccugg 20
<210> 2205
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2205
gcuuuuuggg agaaugaugu 20
<210> 2206
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2206
ggaaagcagu ggcauaauca 20
<210> 2207
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2207
ggaaagcccg ugucaaugaa 20
<210> 2208
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2208
ggaaaggaag aaaccaaaau 20
<210> 2209
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2209
ggaaagggau ucauggcguc 20
<210> 2210
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2210
ggaaaugauc uggcugaauc 20
<210> 2211
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2211
ggaaccguga uaagccuuuc 20
<210> 2212
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2212
ggaagaaacc aaaaucccaa 20
<210> 2213
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2213
ggaagaugaa aggggagggg 20
<210> 2214
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2214
ggaagcacua ggugggcgga 20
<210> 2215
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2215
ggaaggguuc ugggcaggga 20
<210> 2216
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2216
ggaagguaca aacccaccuc 20
<210> 2217
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2217
ggaagugaau ggcuuggagg 20
<210> 2218
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2218
ggaaguggca ucauuuggug 20
<210> 2219
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2219
ggaagugggu aggggucggg 20
<210> 2220
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2220
ggaaguuuug aguuucucuc 20
<210> 2221
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2221
ggaauggaag uggguagggg 20
<210> 2222
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2222
ggacaauugc caaucccuug 20
<210> 2223
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2223
ggacacagug uuuugucccu 20
<210> 2224
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2224
ggacaccagc cuggugccca 20
<210> 2225
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2225
ggacagagag gggcagguug 20
<210> 2226
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2226
ggacagugcc caugcaaugg 20
<210> 2227
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2227
ggacauaaag acgacaaugg 20
<210> 2228
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2228
ggacaucagu gcaacaguaa 20
<210> 2229
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2229
ggacaucauu cucccaaaaa 20
<210> 2230
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2230
ggaccaggau gacaccucca 20
<210> 2231
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2231
ggacccccug gcccugccuc 20
<210> 2232
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2232
ggacgcauuu acgugcuccg 20
<210> 2233
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2233
ggacgggacu ccaggcagau 20
<210> 2234
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2234
ggacuccagg cagauguuca 20
<210> 2235
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2235
ggacugugug caacgcuuuu 20
<210> 2236
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2236
ggacuucaaa gccgugaucg 20
<210> 2237
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2237
ggacuucagg uucuuucuga 20
<210> 2238
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2238
ggagaaugau guccccguug 20
<210> 2239
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2239
ggagaccacg ggaauggaag 20
<210> 2240
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2240
ggagaccagg ccugagcaac 20
<210> 2241
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2241
ggagagaaac ucaaaacuuc 20
<210> 2242
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2242
ggagagaaau ggagguguca 20
<210> 2243
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2243
ggagagacag ugacagccuc 20
<210> 2244
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2244
ggagaugggu gucacuuuuu 20
<210> 2245
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2245
ggagcacgua aaugcguccc 20
<210> 2246
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2246
ggaggaugac guggcgugaa 20
<210> 2247
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2247
ggaggauggg caccaggcug 20
<210> 2248
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2248
ggaggauggu uugagcucag 20
<210> 2249
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2249
ggaggcagaa caggcuucgg 20
<210> 2250
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2250
ggaggcauuu gcauagaagu 20
<210> 2251
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2251
ggaggcugag cuggaucacu 20
<210> 2252
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2252
ggaggcuguc acugucucuc 20
<210> 2253
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2253
ggaggggaug ucaggcccag 20
<210> 2254
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2254
ggagguguca uccugguccc 20
<210> 2255
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2255
ggagucaacg uguuuaccuc 20
<210> 2256
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2256
ggagucccgu cccugcccag 20
<210> 2257
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2257
ggagucugac ggaggcuguc 20
<210> 2258
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2258
ggaguuggag accaggccug 20
<210> 2259
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2259
ggauaagaga aacaggcccg 20
<210> 2260
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2260
ggaucccagg ccagggaaag 20
<210> 2261
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2261
ggaucccauc ccaacacaca 20
<210> 2262
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2262
ggaucguuug acgggacuuc 20
<210> 2263
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2263
ggaucucgcu uuguugcuca 20
<210> 2264
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2264
ggaugacacc uccauuucuc 20
<210> 2265
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2265
ggaugacgug gcgugaacau 20
<210> 2266
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2266
ggaugaggca gggccagggg 20
<210> 2267
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2267
ggaugggauc ccaggccagg 20
<210> 2268
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2268
ggaugggcac caggcuggug 20
<210> 2269
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2269
ggaugguuug agcucaggca 20
<210> 2270
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2270
ggaugucagg cccagagaag 20
<210> 2271
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2271
ggauucagcc agaucauuuc 20
<210> 2272
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2272
ggauucaugg cgucggaaau 20
<210> 2273
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2273
ggauuggcaa uuguccccag 20
<210> 2274
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2274
ggauuguguc acgguggaga 20
<210> 2275
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2275
ggauuuuggu uucuuccuuu 20
<210> 2276
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2276
ggauuuuuug uuauguuugc 20
<210> 2277
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2277
ggcaaaggcu aaccuggcug 20
<210> 2278
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2278
ggcaacagau gaagacccua 20
<210> 2279
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2279
ggcaauaacc cccuacacag 20
<210> 2280
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2280
ggcaaugcuu uggucuucuc 20
<210> 2281
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2281
ggcaauuguc cccagggaca 20
<210> 2282
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2282
ggcaccaacg ggacccccug 20
<210> 2283
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2283
ggcaccaggc ugguguccug 20
<210> 2284
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2284
ggcaccgaga ccaaacucau 20
<210> 2285
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2285
ggcaccugug ucuggccaaa 20
<210> 2286
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2286
ggcacgugcc accguaccca 20
<210> 2287
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2287
ggcacuuaau aaauauuaag 20
<210> 2288
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2288
ggcagaacag gcuucggaca 20
<210> 2289
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2289
ggcagagccu gagucacugg 20
<210> 2290
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2290
ggcagauguu cacgccacgu 20
<210> 2291
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2291
ggcaggcaau gcuuuggucu 20
<210> 2292
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2292
ggcagggacg ggacuccagg 20
<210> 2293
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2293
ggcagggcca gggggucccg 20
<210> 2294
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2294
ggcagguuga ccgggacuuc 20
<210> 2295
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2295
ggcaguucuc gauauucacg 20
<210> 2296
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2296
ggcaucauuu ggugaaugag 20
<210> 2297
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2297
ggcauggcga ggcugaggug 20
<210> 2298
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2298
ggcauucauu gacacgggcu 20
<210> 2299
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2299
ggcauuucag aggcaauaac 20
<210> 2300
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2300
ggcauuugag gcugucguga 20
<210> 2301
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2301
ggcauuugca uagaagugga 20
<210> 2302
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2302
ggccaaauuc auuuuuuaag 20
<210> 2303
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2303
ggccaaggua accggguguc 20
<210> 2304
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2304
ggccacgugu ccucacggcc 20
<210> 2305
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2305
ggccagacac aggugccuca 20
<210> 2306
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2306
ggccagaggc caugggcugc 20
<210> 2307
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2307
ggccaggcau ggcgaggcug 20
<210> 2308
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2308
ggccagggaa agcccguguc 20
<210> 2309
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2309
ggccaggggg ucccguuggu 20
<210> 2310
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2310
ggccaugggc ugcugaugca 20
<210> 2311
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2311
ggcccagaga agcaaguggc 20
<210> 2312
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2312
ggccccgaga auagucacug 20
<210> 2313
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2313
ggcccggggg gaccaggaug 20
<210> 2314
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2314
ggcccugccu cauccaccaa 20
<210> 2315
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2315
ggcccugugu aggggguuau 20
<210> 2316
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2316
ggccggcgag gucucaggaa 20
<210> 2317
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2317
ggccgugagg acacguggcc 20
<210> 2318
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2318
ggccucaccg ugcauguuuu 20
<210> 2319
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2319
ggccucuggc caggcauggc 20
<210> 2320
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2320
ggccugacau ccccuccccu 20
<210> 2321
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2321
ggccugagca acaaagcgag 20
<210> 2322
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2322
ggccugcacc cagguguggc 20
<210> 2323
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2323
ggccugggau cccaucccaa 20
<210> 2324
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2324
ggccuggucu ccaacuccug 20
<210> 2325
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2325
ggccuguuuc ucuuauccuu 20
<210> 2326
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2326
ggccuuguuu uauucaaaga 20
<210> 2327
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2327
ggcgaggcug aggugggagg 20
<210> 2328
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2328
ggcgaggucu caggaagggu 20
<210> 2329
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2329
ggcgauuuca gaaagaaccu 20
<210> 2330
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2330
ggcggacaua aagacgacaa 20
<210> 2331
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2331
ggcgucggaa augaucuggc 20
<210> 2332
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2332
ggcgugaaca ucugccugga 20
<210> 2333
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2333
ggcgugaggc accugugucu 20
<210> 2334
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2334
ggcuaaccug gcugucuagc 20
<210> 2335
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2335
ggcuacaaaa accuucuaua 20
<210> 2336
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2336
ggcucugccu cugggaagug 20
<210> 2337
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2337
ggcugaaucc gugguggcac 20
<210> 2338
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2338
ggcugagcug gaucacuuga 20
<210> 2339
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2339
ggcugcugau gcaccaugca 20
<210> 2340
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2340
ggcuggaaag caguggcaua 20
<210> 2341
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2341
ggcugguguc cugacagcca 20
<210> 2342
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2342
ggcugucacu gucucuccgg 20
<210> 2343
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2343
ggcugucagg acaccagccu 20
<210> 2344
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2344
ggcugucuag caaggcuugc 20
<210> 2345
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2345
ggcuuaagga agguacaaac 20
<210> 2346
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2346
ggcuuagaga uugguggaug 20
<210> 2347
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2347
ggcuuaucac gguucccugc 20
<210> 2348
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2348
ggcuucggac agugcccaug 20
<210> 2349
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2349
ggcuucuggg agaugggugu 20
<210> 2350
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2350
ggcuugcaua gaagagguaa 20
<210> 2351
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2351
ggcuuggagg cauuugcaua 20
<210> 2352
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2352
ggcuuggguu gggauuuugg 20
<210> 2353
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2353
ggcuuucaac acacaacagc 20
<210> 2354
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2354
ggcuuucccu ggccugggau 20
<210> 2355
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2355
ggcuuugaag ucccggucaa 20
<210> 2356
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2356
gggaaagccc gugucaauga 20
<210> 2357
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2357
gggaaccgug auaagccuuu 20
<210> 2358
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2358
gggaagugaa uggcuuggag 20
<210> 2359
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2359
gggaaguggc aucauuuggu 20
<210> 2360
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2360
gggaauggaa guggguaggg 20
<210> 2361
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2361
gggacaauug ccaaucccuu 20
<210> 2362
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2362
gggacacagu guuuuguccc 20
<210> 2363
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2363
gggacagaga ggggcagguu 20
<210> 2364
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2364
gggacaucau ucucccaaaa 20
<210> 2365
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2365
gggaccagga ugacaccucc 20
<210> 2366
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2366
gggacccccu ggcccugccu 20
<210> 2367
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2367
gggacgcauu uacgugcucc 20
<210> 2368
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2368
gggacgggac uccaggcaga 20
<210> 2369
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2369
gggacuccag gcagauguuc 20
<210> 2370
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2370
gggacuucaa agccgugauc 20
<210> 2371
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2371
gggacuucag guucuuucug 20
<210> 2372
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2372
gggagaauga uguccccguu 20
<210> 2373
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2373
gggagauggg ugucacuuuu 20
<210> 2374
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2374
gggaggaugg gcaccaggcu 20
<210> 2375
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2375
gggaggaugg uuugagcuca 20
<210> 2376
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2376
gggaggcaga acaggcuucg 20
<210> 2377
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2377
gggaggcuga gcuggaucac 20
<210> 2378
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2378
gggaggggau gucaggccca 20
<210> 2379
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2379
gggagucuga cggaggcugu 20
<210> 2380
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2380
gggaucccag gccagggaaa 20
<210> 2381
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2381
gggaucccau cccaacacac 20
<210> 2382
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2382
gggaucucgc uuuguugcuc 20
<210> 2383
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2383
gggaugggau cccaggccag 20
<210> 2384
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2384
gggaugucag gcccagagaa 20
<210> 2385
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2385
gggauuacag gcgugaggca 20
<210> 2386
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2386
gggauucaug gcgucggaaa 20
<210> 2387
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2387
gggauuggca auugucccca 20
<210> 2388
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2388
gggauuuugg uuucuuccuu 20
<210> 2389
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2389
gggauuuuuu guuauguuug 20
<210> 2390
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2390
gggcaaaggc uaaccuggcu 20
<210> 2391
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2391
gggcaccagg cugguguccu 20
<210> 2392
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2392
gggcacuguc cgaagccugu 20
<210> 2393
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2393
gggcagggac gggacuccag 20
<210> 2394
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2394
gggcagguug accgggacuu 20
<210> 2395
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2395
gggccagggg gucccguugg 20
<210> 2396
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2396
gggccccgag aauagucacu 20
<210> 2397
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2397
gggcccugug uaggggguua 20
<210> 2398
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2398
gggccugaca uccccucccc 20
<210> 2399
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2399
gggccuguuu cucuuauccu 20
<210> 2400
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2400
gggcggacau aaagacgaca 20
<210> 2401
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2401
gggcugcuga ugcaccaugc 20
<210> 2402
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2402
gggcuuuccc uggccuggga 20
<210> 2403
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2403
ggggaaguga auggcuugga 20
<210> 2404
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2404
ggggacaauu gccaaucccu 20
<210> 2405
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2405
ggggacacag uguuuugucc 20
<210> 2406
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2406
ggggacagag aggggcaggu 20
<210> 2407
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2407
ggggacauca uucucccaaa 20
<210> 2408
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2408
ggggaccagg augacaccuc 20
<210> 2409
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2409
ggggagggga ugucaggccc 20
<210> 2410
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2410
ggggauguca ggcccagaga 20
<210> 2411
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2411
ggggauuuuu uguuauguuu 20
<210> 2412
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2412
ggggcagguu gaccgggacu 20
<210> 2413
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2413
ggggcccugu guaggggguu 20
<210> 2414
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2414
gggggacaca guguuuuguc 20
<210> 2415
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2415
gggggaccag gaugacaccu 20
<210> 2416
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2416
ggggggacac aguguuuugu 20
<210> 2417
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2417
ggggggacca ggaugacacc 20
<210> 2418
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2418
gggggucccg uuggugccau 20
<210> 2419
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2419
gggggugaca gggcaaaggc 20
<210> 2420
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2420
ggggguuauu gccucugaaa 20
<210> 2421
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2421
ggggucccgu uggugccauc 20
<210> 2422
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2422
ggggucggga ggaugggcac 20
<210> 2423
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2423
ggggugacag ggcaaaggcu 20
<210> 2424
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2424
gggguuauug ccucugaaau 20
<210> 2425
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2425
gggguuuggc uuagagauug 20
<210> 2426
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2426
ggguacggug gcacgugccu 20
<210> 2427
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2427
ggguaggggu cgggaggaug 20
<210> 2428
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2428
ggguaugugu uuaaaacaug 20
<210> 2429
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2429
gggucaugau ucggggguga 20
<210> 2430
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2430
gggucccguu ggugccaucu 20
<210> 2431
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2431
gggucgggag gaugggcacc 20
<210> 2432
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2432
gggugacagg gcaaaggcua 20
<210> 2433
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2433
gggugaccag ugacucaggc 20
<210> 2434
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2434
gggugcaggc cacguguccu 20
<210> 2435
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2435
ggguggguca ugauucgggg 20
<210> 2436
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2436
gggugucacu uuuuaaacca 20
<210> 2437
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2437
gggugucuca ggcacuuaau 20
<210> 2438
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2438
ggguuauugc cucugaaaug 20
<210> 2439
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2439
ggguucuggg cagggacggg 20
<210> 2440
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2440
ggguugggau uuugguuucu 20
<210> 2441
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2441
ggguuuggcu uagagauugg 20
<210> 2442
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2442
ggguuuguac cuuccuuaag 20
<210> 2443
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2443
gguaaacacg uugacuccug 20
<210> 2444
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2444
gguaaccggg ugucucaggc 20
<210> 2445
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2445
gguacaaacc caccucgaaa 20
<210> 2446
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2446
gguagggguc gggaggaugg 20
<210> 2447
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2447
gguauguguu uaaaacaugc 20
<210> 2448
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2448
ggucaaccug ccccucucug 20
<210> 2449
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2449
ggucagucug gaggaugacg 20
<210> 2450
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2450
ggucaugauu cgggggugac 20
<210> 2451
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2451
gguccccccg ggccuguuuc 20
<210> 2452
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2452
ggucccguug gugccaucug 20
<210> 2453
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2453
ggucgggagg augggcacca 20
<210> 2454
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2454
ggucuccuug cacuuucuca 20
<210> 2455
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2455
ggucucggug ccaccacgga 20
<210> 2456
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2456
ggucuucucu gucuuugaau 20
<210> 2457
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2457
ggugaaugag uuuggucucg 20
<210> 2458
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2458
ggugacaggg caaaggcuaa 20
<210> 2459
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2459
ggugaccagu gacucaggcu 20
<210> 2460
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2460
ggugcaggcc acguguccuc 20
<210> 2461
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2461
ggugcaucag cagcccaugg 20
<210> 2462
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2462
ggugccacca cggauucagc 20
<210> 2463
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2463
ggugccaucu gcuguugugu 20
<210> 2464
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2464
ggugcccauc cucccgaccc 20
<210> 2465
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2465
gguggagaga aacucaaaac 20
<210> 2466
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2466
gguggaugag gcagggccag 20
<210> 2467
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2467
ggugggagga ugguuugagc 20
<210> 2468
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2468
ggugggcgga cauaaagacg 20
<210> 2469
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2469
ggugggucau gauucggggg 20
<210> 2470
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2470
gguggguuug uaccuuccuu 20
<210> 2471
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2471
ggugucacuu uuuaaaccac 20
<210> 2472
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2472
ggugucaucc uggucccccc 20
<210> 2473
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2473
gguguccuga cagccacacc 20
<210> 2474
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2474
ggugucucag gcacuuaaua 20
<210> 2475
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2475
gguguggcug ucaggacacc 20
<210> 2476
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2476
gguuaccuug gccgugagga 20
<210> 2477
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2477
gguuagccuu ugcccuguca 20
<210> 2478
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2478
gguuauugcc ucugaaaugc 20
<210> 2479
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2479
gguucugggc agggacggga 20
<210> 2480
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2480
gguucuuucu gaaaucgccg 20
<210> 2481
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2481
gguugaccgg gacuucaaag 20
<210> 2482
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2482
gguugcugua uuuguucagu 20
<210> 2483
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2483
gguugggauu uugguuucuu 20
<210> 2484
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2484
gguuuaaaaa gugacaccca 20
<210> 2485
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2485
gguuucggag cacguaaaug 20
<210> 2486
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2486
gguuucuucc uuuccucgug 20
<210> 2487
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2487
gguuugagcu caggcauuug 20
<210> 2488
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2488
gguuuggcuu agagauuggu 20
<210> 2489
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2489
gguuuguacc uuccuuaagc 20
<210> 2490
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2490
gguuuuugua gagaugggau 20
<210> 2491
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2491
gguuuuugua gccugaaugu 20
<210> 2492
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2492
guaaacacgu ugacuccuga 20
<210> 2493
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2493
guaaaugcgu cccuguacag 20
<210> 2494
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2494
guaacacggc gauuucagaa 20
<210> 2495
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2495
guaaccgggu gucucaggca 20
<210> 2496
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2496
guaagacauu caggcuacaa 20
<210> 2497
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2497
guaagacccc aucucuuaaa 20
<210> 2498
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2498
guacaaaccc accucgaaag 20
<210> 2499
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2499
guacaaagau uauuugcacg 20
<210> 2500
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2500
guacaacucu gaacugagaa 20
<210> 2501
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2501
guacacagug uacaacucug 20
<210> 2502
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2502
guacacugug uacauuuggc 20
<210> 2503
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2503
guacagauag uggggauuuu 20
<210> 2504
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2504
guacagggac gcauuuacgu 20
<210> 2505
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2505
guacauaaag aagaggcauu 20
<210> 2506
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2506
guacccagcu gauuuuuaac 20
<210> 2507
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2507
guaccuuccu uaagccagga 20
<210> 2508
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2508
guagccugaa ugucuuacug 20
<210> 2509
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2509
guaggggguu auugccucug 20
<210> 2510
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2510
guaggggucg ggaggauggg 20
<210> 2511
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2511
guauagaagg uuuuuguagc 20
<210> 2512
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2512
guauauuggu ugaaacuguu 20
<210> 2513
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2513
guaugagugg cuucugggag 20
<210> 2514
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2514
guauguauga guggcuucug 20
<210> 2515
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2515
guauguguuu aaaacaugca 20
<210> 2516
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2516
guauuucuga aauagggucu 20
<210> 2517
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2517
guauuuguuc agugacuauu 20
<210> 2518
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2518
gucaaacgau ccagacugga 20
<210> 2519
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2519
gucaaccugc cccucucugu 20
<210> 2520
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2520
gucaacgugu uuaccucuuc 20
<210> 2521
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2521
gucaaugaau gccggggaca 20
<210> 2522
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2522
gucacaaggg auuggcaauu 20
<210> 2523
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2523
gucacccccg aaucaugacc 20
<210> 2524
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2524
gucacccuua auauuuauua 20
<210> 2525
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2525
gucacggugg agagaaacuc 20
<210> 2526
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2526
gucacugaac aaauacagca 20
<210> 2527
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2527
gucacugguc acccuuaaua 20
<210> 2528
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2528
gucacugucu cuccggacau 20
<210> 2529
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2529
gucacuuuuu aaaccacugu 20
<210> 2530
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2530
gucagacucc cgcgugaaga 20
<210> 2531
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2531
gucaggacac cagccuggug 20
<210> 2532
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2532
gucaggccca gagaagcaag 20
<210> 2533
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2533
gucagucugg aggaugacgu 20
<210> 2534
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2534
gucauccucc agacugacca 20
<210> 2535
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2535
gucauccugg uccccccggg 20
<210> 2536
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2536
gucaugauuc gggggugaca 20
<210> 2537
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2537
guccaguucg ugcaaauaau 20
<210> 2538
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2538
guccccaggg acaaaacacu 20
<210> 2539
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2539
guccccccgg gccuguuucu 20
<210> 2540
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2540
guccccggca uucauugaca 20
<210> 2541
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2541
guccccguug uauguaugag 20
<210> 2542
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2542
gucccgguca accugccccu 20
<210> 2543
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2543
gucccgucaa acgauccaga 20
<210> 2544
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2544
gucccguccc ugcccagaac 20
<210> 2545
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2545
gucccguugg ugccaucugc 20
<210> 2546
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2546
gucccugccc agaacccuuc 20
<210> 2547
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2547
gucccugggg acaauugcca 20
<210> 2548
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2548
gucccuguac agauaguggg 20
<210> 2549
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2549
guccgaagcc uguucugccu 20
<210> 2550
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2550
guccgcccac cuagugcuuc 20
<210> 2551
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2551
guccggagag acagugacag 20
<210> 2552
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2552
guccucacgg ccaagguaac 20
<210> 2553
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2553
guccugacag ccacaccugg 20
<210> 2554
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2554
gucggaaaug aucuggcuga 20
<210> 2555
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2555
gucgggagga ugggcaccag 20
<210> 2556
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2556
gucgucuuua uguccgccca 20
<210> 2557
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2557
gucgugagcu augauuaugc 20
<210> 2558
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2558
gucgugugug uugggauggg 20
<210> 2559
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2559
gucguugaug gguauguguu 20
<210> 2560
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2560
gucuagcaag gcuugcauag 20
<210> 2561
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2561
gucucaggaa ggguucuggg 20
<210> 2562
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2562
gucucaggca cuuaauaaau 20
<210> 2563
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2563
gucuccuugc acuuucucag 20
<210> 2564
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2564
gucucggugc caccacggau 20
<210> 2565
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2565
gucucuccgg acaucagugc 20
<210> 2566
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2566
gucugacgga ggcugucacu 20
<210> 2567
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2567
gucuggagga ugacguggcg 20
<210> 2568
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2568
gucuggaucg uuugacggga 20
<210> 2569
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2569
gucuggccaa auucauuuuu 20
<210> 2570
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2570
gucuucucug ucuuugaaua 20
<210> 2571
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2571
gucuuuaugu ccgcccaccu 20
<210> 2572
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2572
gucuuucgag guggguuugu 20
<210> 2573
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2573
gucuuugaau aaaacaaggc 20
<210> 2574
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2574
gugaacaucu gccuggaguc 20
<210> 2575
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2575
gugaagaugu cacaagggau 20
<210> 2576
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2576
gugaaggaua agagaaacag 20
<210> 2577
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2577
gugaauaucg agaacugcca 20
<210> 2578
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2578
gugaaugagu uuggucucgg 20
<210> 2579
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2579
gugaauggcu uggaggcauu 20
<210> 2580
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2580
gugacacaau ccucaaacau 20
<210> 2581
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2581
gugacaccca ucucccagaa 20
<210> 2582
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2582
gugacagccu ccgucagacu 20
<210> 2583
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2583
gugacagggc aaaggcuaac 20
<210> 2584
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2584
gugacaucuu cacgcgggag 20
<210> 2585
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2585
gugaccagug acucaggcuc 20
<210> 2586
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2586
gugacuauuc ucggggcccu 20
<210> 2587
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2587
gugacucagg cucugccucu 20
<210> 2588
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2588
gugagcuaug auuaugccac 20
<210> 2589
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2589
gugaggacac guggccugca 20
<210> 2590
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2590
gugaggcacc ugugucuggc 20
<210> 2591
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2591
gugauaacag uuucaaccaa 20
<210> 2592
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2592
gugauaagcc uuucugguuu 20
<210> 2593
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2593
gugauccagc ucagccuccc 20
<210> 2594
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2594
gugaucguga auaucgagaa 20
<210> 2595
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2595
gugcaaaaua auaacacaaa 20
<210> 2596
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2596
gugcaaacau aacaaaaaau 20
<210> 2597
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2597
gugcaacagu aacacggcga 20
<210> 2598
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2598
gugcaacgcu uuuugggaga 20
<210> 2599
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2599
gugcaaggag accacgggaa 20
<210> 2600
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2600
gugcaggcca cguguccuca 20
<210> 2601
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2601
gugcagggaa ccgugauaag 20
<210> 2602
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2602
gugcaucagc agcccauggc 20
<210> 2603
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2603
gugcauguuu uaaacacaua 20
<210> 2604
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2604
gugccaccac ggauucagcc 20
<210> 2605
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2605
gugccaccgu acccagcuga 20
<210> 2606
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2606
gugccaucug cuguugugug 20
<210> 2607
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2607
gugcccaucc ucccgacccc 20
<210> 2608
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2608
gugcccaugc aauggcuugg 20
<210> 2609
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2609
gugccugaga cacccgguua 20
<210> 2610
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2610
gugcuccgaa accagaaagg 20
<210> 2611
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2611
gugcuuccac uucuaugcaa 20
<210> 2612
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2612
guggaagcac uaggugggcg 20
<210> 2613
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2613
guggagagaa acucaaaacu 20
<210> 2614
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2614
guggaugagg cagggccagg 20
<210> 2615
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2615
guggcaccga gaccaaacuc 20
<210> 2616
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2616
guggcaucau uuggugaaug 20
<210> 2617
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2617
guggcgugaa caucugccug 20
<210> 2618
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2618
guggcuguca ggacaccagc 20
<210> 2619
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2619
guggcuucug ggagaugggu 20
<210> 2620
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2620
guggcuuuca acacacaaca 20
<210> 2621
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2621
gugggaggau gguuugagcu 20
<210> 2622
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2622
gugggcggac auaaagacga 20
<210> 2623
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2623
guggggauuu uuuguuaugu 20
<210> 2624
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2624
guggguaggg gucgggagga 20
<210> 2625
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2625
gugggucaug auucgggggu 20
<210> 2626
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2626
guggguuugu accuuccuua 20
<210> 2627
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2627
guggucuccu ugcacuuucu 20
<210> 2628
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2628
gugguggcac cgagaccaaa 20
<210> 2629
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2629
gugguuuaaa aagugacacc 20
<210> 2630
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2630
guguacaacu cugaacugag 20
<210> 2631
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2631
guguacauuu ggcauuugug 20
<210> 2632
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2632
guguaggggg uuauugccuc 20
<210> 2633
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2633
gugucaauga augccgggga 20
<210> 2634
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2634
gugucacggu ggagagaaac 20
<210> 2635
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2635
gugucacuuu uuaaaccacu 20
<210> 2636
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2636
gugucauccu gguccccccg 20
<210> 2637
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2637
guguccucac ggccaaggua 20
<210> 2638
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2638
guguccugac agccacaccu 20
<210> 2639
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2639
gugucucagg cacuuaauaa 20
<210> 2640
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2640
gugucuggcc aaauucauuu 20
<210> 2641
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2641
gugucuuucg agguggguuu 20
<210> 2642
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2642
gugugcaacg cuuuuuggga 20
<210> 2643
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2643
guguggcugu caggacacca 20
<210> 2644
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2644
guguguguug ggaugggauc 20
<210> 2645
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2645
guguguugaa agccacuugc 20
<210> 2646
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2646
guguguuggg augggauccc 20
<210> 2647
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2647
guguuacugu ugcacugaug 20
<210> 2648
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2648
guguuauuau uuugcacugu 20
<210> 2649
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2649
guguugaaag ccacuugcuu 20
<210> 2650
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2650
guguugggau gggaucccag 20
<210> 2651
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2651
guguuuaaaa caugcacggu 20
<210> 2652
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2652
guguuuaccu cuucuaugca 20
<210> 2653
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2653
guguuuuguc ccuggggaca 20
<210> 2654
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2654
guuaaaaauc agcuggguac 20
<210> 2655
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2655
guuaccuugg ccgugaggac 20
<210> 2656
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2656
guuacuguug cacugauguc 20
<210> 2657
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2657
guuagccuuu gcccugucac 20
<210> 2658
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2658
guuauguuug cacuuuguau 20
<210> 2659
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2659
guuauuauuu ugcacuguuu 20
<210> 2660
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2660
guuauugccu cugaaaugcc 20
<210> 2661
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2661
guucacgcca cgucauccuc 20
<210> 2662
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2662
guucagaguu guacacugug 20
<210> 2663
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2663
guucaggagu uggagaccag 20
<210> 2664
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2664
guucagugac uauucucggg 20
<210> 2665
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2665
guucgugcaa auaaucuuug 20
<210> 2666
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2666
guucucgaua uucacgauca 20
<210> 2667
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2667
guucugccuc ccagaugaau 20
<210> 2668
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2668
guucugggca gggacgggac 20
<210> 2669
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2669
guucuuucug aaaucgccgu 20
<210> 2670
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2670
guugaaagcc acuugcuucu 20
<210> 2671
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2671
guugaccggg acuucaaagc 20
<210> 2672
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2672
guugacuccu gaguuuaggg 20
<210> 2673
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2673
guugaugggu auguguuuaa 20
<210> 2674
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2674
guugcacaca guccaguucg 20
<210> 2675
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2675
guugcacuga uguccggaga 20
<210> 2676
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2676
guugcucagg ccuggucucc 20
<210> 2677
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2677
guugcuguau uuguucagug 20
<210> 2678
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2678
guuggagacc aggccugagc 20
<210> 2679
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2679
guugggaugg gaucccaggc 20
<210> 2680
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2680
guugggauuu ugguuucuuc 20
<210> 2681
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2681
guuggugcca ucugcuguug 20
<210> 2682
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2682
guuguacacu guguacauuu 20
<210> 2683
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2683
guuguaugua ugaguggcuu 20
<210> 2684
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2684
guuguauuuc ugaaauaggg 20
<210> 2685
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2685
guuguguguu gaaagccacu 20
<210> 2686
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2686
guuuaaaaag ugacacccau 20
<210> 2687
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2687
guuuaaaaca ugcacgguga 20
<210> 2688
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2688
guuuaccucu ucuaugcaag 20
<210> 2689
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2689
guuuaggggu uuggcuuaga 20
<210> 2690
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2690
guuucaacca auauacaaag 20
<210> 2691
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2691
guuucggagc acguaaaugc 20
<210> 2692
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2692
guuucucucc accgugacac 20
<210> 2693
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2693
guuucucuua uccuucacga 20
<210> 2694
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2694
guuucuuccu uuccucguga 20
<210> 2695
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2695
guuugacggg acuucagguu 20
<210> 2696
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2696
guuugagcuc aggcauuuga 20
<210> 2697
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2697
guuugaggau ugugucacgg 20
<210> 2698
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2698
guuugcacuu uguauauugg 20
<210> 2699
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2699
guuuggcuua gagauuggug 20
<210> 2700
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2700
guuuggucuc ggugccacca 20
<210> 2701
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2701
guuuguaccu uccuuaagcc 20
<210> 2702
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2702
guuuuaaaca cauacccauc 20
<210> 2703
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2703
guuuuauuca aagacagaga 20
<210> 2704
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2704
guuuucuguc guguguguug 20
<210> 2705
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2705
guuuugaguu ucucuccacc 20
<210> 2706
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2706
guuuuguccc uggggacaau 20
<210> 2707
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2707
guuuuuguag agaugggauc 20
<210> 2708
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2708
guuuuuguag ccugaauguc 20
<210> 2709
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2709
uaaaaaauga auuuggccag 20
<210> 2710
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2710
uaaaaaguga cacccaucuc 20
<210> 2711
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2711
uaaaaaucag cuggguacgg 20
<210> 2712
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2712
uaaaacaaag cucuggcagg 20
<210> 2713
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2713
uaaaacaagg ccggcgaggu 20
<210> 2714
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2714
uaaaacaugc acggugaggc 20
<210> 2715
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2715
uaaacacaua cccaucaacg 20
<210> 2716
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2716
uaaacacguu gacuccugag 20
<210> 2717
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2717
uaaaccacug uauagaaggu 20
<210> 2718
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2718
uaaacucagg agucaacgug 20
<210> 2719
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2719
uaaagaagag gcauuucaga 20
<210> 2720
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2720
uaaagacgac aauggcaguu 20
<210> 2721
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2721
uaaauaaauc cuccagucug 20
<210> 2722
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2722
uaaauauuaa gggugaccag 20
<210> 2723
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2723
uaaauccucc agucuggauc 20
<210> 2724
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2724
uaaaugcguc ccuguacaga 20
<210> 2725
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2725
uaacaaaaaa uccccacuau 20
<210> 2726
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2726
uaacacaaau gccaaaugua 20
<210> 2727
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2727
uaacacggcg auuucagaaa 20
<210> 2728
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2728
uaacccccua cacagggccc 20
<210> 2729
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2729
uaaccgggug ucucaggcac 20
<210> 2730
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2730
uaaccuggcu gucuagcaag 20
<210> 2731
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2731
uaacuuuuug guuuuuguag 20
<210> 2732
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2732
uaagacauuc aggcuacaaa 20
<210> 2733
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2733
uaagacccca ucucuuaaaa 20
<210> 2734
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2734
uaagagaaac aggcccgggg 20
<210> 2735
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2735
uaagccaaac cccuaaacuc 20
<210> 2736
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2736
uaagccagga aagggauuca 20
<210> 2737
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2737
uaagccuuuc ugguuucgga 20
<210> 2738
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2738
uaaggaaggu acaaacccac 20
<210> 2739
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2739
uaagggugac cagugacuca 20
<210> 2740
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2740
uaagugccug agacacccgg 20
<210> 2741
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2741
uaauaaauau uaagggugac 20
<210> 2742
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2742
uaauaacaca aaugccaaau 20
<210> 2743
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2743
uaauauuuau uaagugccug 20
<210> 2744
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2744
uaaucauagc ucacgacagc 20
<210> 2745
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2745
uaaucuuugu acauaaagaa 20
<210> 2746
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2746
uaauugauca caguaagaca 20
<210> 2747
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2747
uacaaaaacc uucuauacag 20
<210> 2748
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2748
uacaaaccca ccucgaaaga 20
<210> 2749
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2749
uacaaagauu auuugcacga 20
<210> 2750
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2750
uacaacgggg acaucauucu 20
<210> 2751
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2751
uacaacucug aacugagaaa 20
<210> 2752
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2752
uacacagggc cccgagaaua 20
<210> 2753
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2753
uacacagugu acaacucuga 20
<210> 2754
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2754
uacacugugu acauuuggca 20
<210> 2755
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2755
uacagauagu ggggauuuuu 20
<210> 2756
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2756
uacagcaacc aggguuugca 20
<210> 2757
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2757
uacaggcgug aggcaccugu 20
<210> 2758
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2758
uacagggacg cauuuacgug 20
<210> 2759
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2759
uacagugguu uaaaaaguga 20
<210> 2760
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2760
uacauaaaga agaggcauuu 20
<210> 2761
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2761
uacauacaac ggggacauca 20
<210> 2762
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2762
uacccagcug auuuuuaacu 20
<210> 2763
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2763
uacccaucaa cgacaagauu 20
<210> 2764
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2764
uaccucuucu augcaagccu 20
<210> 2765
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2765
uaccuuccuu aagccaggaa 20
<210> 2766
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2766
uaccuuggcc gugaggacac 20
<210> 2767
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2767
uacgugcucc gaaaccagaa 20
<210> 2768
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2768
uacuauguug cccaggcugg 20
<210> 2769
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2769
uacuguugca cugauguccg 20
<210> 2770
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2770
uagaagaggu aaacacguug 20
<210> 2771
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2771
uagaagguuu uuguagccug 20
<210> 2772
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2772
uagaagugga agcacuaggu 20
<210> 2773
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2773
uagacagcca gguuagccuu 20
<210> 2774
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2774
uagagauugg uggaugaggc 20
<210> 2775
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2775
uagcaaggcu ugcauagaag 20
<210> 2776
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2776
uagccugaau gucuuacugu 20
<210> 2777
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2777
uagccuuugc ccugucaccc 20
<210> 2778
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2778
uagcucacga cagccucaaa 20
<210> 2779
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2779
uaggggguua uugccucuga 20
<210> 2780
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2780
uaggggucgg gaggaugggc 20
<210> 2781
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2781
uagggguuug gcuuagagau 20
<210> 2782
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2782
uaggugggcg gacauaaaga 20
<210> 2783
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2783
uagucacuga acaaauacag 20
<210> 2784
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2784
uagugcuucc acuucuaugc 20
<210> 2785
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2785
uaguggggau uuuuuguuau 20
<210> 2786
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2786
uaguuguauu ucugaaauag 20
<210> 2787
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2787
uauaaaacaa agcucuggca 20
<210> 2788
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2788
uauacagugg uuuaaaaagu 20
<210> 2789
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2789
uauagaaggu uuuuguagcc 20
<210> 2790
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2790
uauaguugua uuucugaaau 20
<210> 2791
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2791
uauauaaaac aaagcucugg 20
<210> 2792
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2792
uauauauuua uucaucuggg 20
<210> 2793
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2793
uauauuuauu caucugggag 20
<210> 2794
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2794
uauccuucac gaggaaagga 20
<210> 2795
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2795
uaucgagaac ugccauuguc 20
<210> 2796
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2796
uaucuguaca gggacgcauu 20
<210> 2797
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2797
uaugaguggc uucugggaga 20
<210> 2798
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2798
uaugauuaug ccacugcuuu 20
<210> 2799
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2799
uaugcaaaug ccuccaagcc 20
<210> 2800
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2800
uaugcaagcc uugcuagaca 20
<210> 2801
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2801
uaugccacug cuuuccagcc 20
<210> 2802
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2802
uauguacaaa gauuauuugc 20
<210> 2803
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2803
uauguaugag uggcuucugg 20
<210> 2804
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2804
uauguccgcc caccuagugc 20
<210> 2805
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2805
uauguguuua aaacaugcac 20
<210> 2806
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2806
uauguuugca cuuuguauau 20
<210> 2807
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2807
uauuaagggu gaccagugac 20
<210> 2808
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2808
uauuaagugc cugagacacc 20
<210> 2809
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2809
uauuauuuug cacuguuuuc 20
<210> 2810
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2810
uauucaaaga cagagaagac 20
<210> 2811
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2811
uauucacgau cacggcuuug 20
<210> 2812
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2812
uauucaucug ggaggcagaa 20
<210> 2813
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2813
uauucucggg gcccugugua 20
<210> 2814
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2814
uauugccucu gaaaugccuc 20
<210> 2815
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2815
uauuuauuca ucugggaggc 20
<210> 2816
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2816
uauuuauuuu ugcaaacccu 20
<210> 2817
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2817
uauuucugaa auagggucuu 20
<210> 2818
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2818
uauuugcacg aacuggacug 20
<210> 2819
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2819
uauuuguuca gugacuauuc 20
<210> 2820
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2820
uauuuugcac uguuuucugu 20
<210> 2821
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2821
uauuuuugca aacccugguu 20
<210> 2822
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2822
ucaaaacuuc cuggagagaa 20
<210> 2823
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2823
ucaaacaugg aagaugaaag 20
<210> 2824
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2824
ucaaacgauc cagacuggag 20
<210> 2825
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2825
ucaaagacag agaagaccaa 20
<210> 2826
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2826
ucaaagccgu gaucgugaau 20
<210> 2827
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2827
ucaaaugccu gagcucaaac 20
<210> 2828
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2828
ucaacacaca acagcagaug 20
<210> 2829
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2829
ucaaccaaua uacaaagugc 20
<210> 2830
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2830
ucaaccugcc ccucucuguc 20
<210> 2831
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2831
ucaacgacaa gauuggggaa 20
<210> 2832
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2832
ucaacguguu uaccucuucu 20
<210> 2833
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2833
ucaagugauc cagcucagcc 20
<210> 2834
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2834
ucaaugaaug ccggggacag 20
<210> 2835
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2835
ucacaaggga uuggcaauug 20
<210> 2836
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2836
ucacaggcac gugccaccgu 20
<210> 2837
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2837
ucacaguaag acauucaggc 20
<210> 2838
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2838
ucaccaaaug augccacuuc 20
<210> 2839
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2839
ucacccccga aucaugaccc 20
<210> 2840
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2840
ucacccuuaa uauuuauuaa 20
<210> 2841
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2841
ucaccgugca uguuuuaaac 20
<210> 2842
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2842
ucacgaggaa aggaagaaac 20
<210> 2843
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2843
ucacgaucac ggcuuugaag 20
<210> 2844
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2844
ucacgccacg ucauccucca 20
<210> 2845
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2845
ucacgcggga gucugacgga 20
<210> 2846
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2846
ucacggccaa gguaaccggg 20
<210> 2847
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2847
ucacggcuuu gaagucccgg 20
<210> 2848
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2848
ucacggugga gagaaacuca 20
<210> 2849
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2849
ucacugaaca aauacagcaa 20
<210> 2850
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2850
ucacugguca cccuuaauau 20
<210> 2851
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2851
ucacugucuc uccggacauc 20
<210> 2852
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2852
ucacuucccc aaucuugucg 20
<210> 2853
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2853
ucacuuuuua aaccacugua 20
<210> 2854
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2854
ucagaaagaa ccugaagucc 20
<210> 2855
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2855
ucagacuccc gcgugaagau 20
<210> 2856
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2856
ucagaggcaa uaacccccua 20
<210> 2857
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2857
ucagaguugu acacugugua 20
<210> 2858
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2858
ucagcagccc auggccucug 20
<210> 2859
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2859
ucagccagau cauuuccgac 20
<210> 2860
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2860
ucagccucgc caugccuggc 20
<210> 2861
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2861
ucagcugggu acgguggcac 20
<210> 2862
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2862
ucaggaaggg uucugggcag 20
<210> 2863
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2863
ucaggaguca acguguuuac 20
<210> 2864
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2864
ucaggaguug gagaccaggc 20
<210> 2865
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2865
ucaggcacuu aauaaauauu 20
<210> 2866
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2866
ucaggcauuu gaggcugucg 20
<210> 2867
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2867
ucaggcccag agaagcaagu 20
<210> 2868
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2868
ucaggccugg ucuccaacuc 20
<210> 2869
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2869
ucaggcuaca aaaaccuucu 20
<210> 2870
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2870
ucaggcucug ccucugggaa 20
<210> 2871
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2871
ucagguucuu ucugaaaucg 20
<210> 2872
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2872
ucagugacua uucucggggc 20
<210> 2873
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2873
ucagugcaac aguaacacgg 20
<210> 2874
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2874
ucauacauac aacggggaca 20
<210> 2875
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2875
ucauagcuca cgacagccuc 20
<210> 2876
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2876
ucauccacca aucucuaagc 20
<210> 2877
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2877
ucauccucca gacugaccau 20
<210> 2878
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2878
ucauccuggu ccccccgggc 20
<210> 2879
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2879
ucaucuggga ggcagaacag 20
<210> 2880
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2880
ucaucuucca uguuugagga 20
<210> 2881
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2881
ucaugaccca cccagugucu 20
<210> 2882
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2882
ucaugauucg ggggugacag 20
<210> 2883
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2883
ucauggcguc ggaaaugauc 20
<210> 2884
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2884
ucauucacca aaugaugcca 20
<210> 2885
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2885
ucauucuccc aaaaagcguu 20
<210> 2886
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2886
ucauugacac gggcuuuccc 20
<210> 2887
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2887
ucauuuccga cgccaugaau 20
<210> 2888
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2888
ucauuuggug aaugaguuug 20
<210> 2889
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2889
ucauuuuuua agagaugggg 20
<210> 2890
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2890
uccaagccau ucacuucccc 20
<210> 2891
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2891
uccaccaauc ucuaagccaa 20
<210> 2892
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2892
uccaccguga cacaauccuc 20
<210> 2893
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2893
uccacuucua ugcaaaugcc 20
<210> 2894
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2894
uccagacugg aggauuuauu 20
<210> 2895
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2895
uccaggaagu uuugaguuuc 20
<210> 2896
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2896
uccaggcaga uguucacgcc 20
<210> 2897
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2897
uccagucugg aucguuugac 20
<210> 2898
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2898
uccaguucgu gcaaauaauc 20
<210> 2899
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2899
uccauguuug aggauugugu 20
<210> 2900
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2900
uccauucccg uggucuccuu 20
<210> 2901
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2901
uccauuucuc uccaggaagu 20
<210> 2902
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2902
ucccaaaaag cguugcacac 20
<210> 2903
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2903
ucccaacaca cacgacagaa 20
<210> 2904
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2904
ucccaaccca agccauugca 20
<210> 2905
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2905
ucccaccuca gccucgccau 20
<210> 2906
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2906
ucccagaagc cacucauaca 20
<210> 2907
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2907
ucccagaggc agagccugag 20
<210> 2908
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2908
ucccaggcca gggaaagccc 20
<210> 2909
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2909
ucccauccca acacacacga 20
<210> 2910
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2910
ucccaucucu acaaaaacca 20
<210> 2911
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2911
uccccaaucu ugucguugau 20
<210> 2912
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2912
uccccacuau cuguacaggg 20
<210> 2913
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2913
uccccaggga caaaacacug 20
<210> 2914
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2914
uccccccggg ccuguuucuc 20
<210> 2915
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2915
uccccggcau ucauugacac 20
<210> 2916
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2916
uccccguugu auguaugagu 20
<210> 2917
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2917
uccccucccc uuucaucuuc 20
<210> 2918
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2918
uccccuuuca ucuuccaugu 20
<210> 2919
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2919
ucccgacccc uacccacuuc 20
<210> 2920
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2920
ucccgcguga agaugucaca 20
<210> 2921
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2921
ucccgucaaa cgauccagac 20
<210> 2922
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2922
ucccgucccu gcccagaacc 20
<210> 2923
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2923
ucccgugguc uccuugcacu 20
<210> 2924
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2924
ucccguuggu gccaucugcu 20
<210> 2925
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2925
ucccugccca gaacccuucc 20
<210> 2926
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2926
ucccuggccu gggaucccau 20
<210> 2927
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2927
ucccugggga caauugccaa 20
<210> 2928
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2928
ucccuguaca gauagugggg 20
<210> 2929
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2929
ucccuuguga caucuucacg 20
<210> 2930
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2930
ucccuuuccu ggcuuaagga 20
<210> 2931
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2931
uccgaaacca gaaaggcuua 20
<210> 2932
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2932
uccgaagccu guucugccuc 20
<210> 2933
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2933
uccgacgcca ugaaucccuu 20
<210> 2934
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2934
uccgcccacc uagugcuucc 20
<210> 2935
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2935
uccggacauc agugcaacag 20
<210> 2936
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2936
uccggagaga cagugacagc 20
<210> 2937
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2937
uccgucagac ucccgcguga 20
<210> 2938
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2938
uccguggugg caccgagacc 20
<210> 2939
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2939
uccucaaaca uggaagauga 20
<210> 2940
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2940
uccucacggc caagguaacc 20
<210> 2941
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2941
uccuccaguc uggaucguuu 20
<210> 2942
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2942
uccucccacc ucagccucgc 20
<210> 2943
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2943
uccucccgac cccuacccac 20
<210> 2944
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2944
uccucgugaa ggauaagaga 20
<210> 2945
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2945
uccugaacuc aagugaucca 20
<210> 2946
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2946
uccugacagc cacaccuggg 20
<210> 2947
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2947
uccugagacc ucgccggccu 20
<210> 2948
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2948
uccugaguuu agggguuugg 20
<210> 2949
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2949
uccuggagag aaauggaggu 20
<210> 2950
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2950
uccuggcuua aggaagguac 20
<210> 2951
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2951
uccugguccc cccgggccug 20
<210> 2952
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2952
uccuuaagcc aggaaaggga 20
<210> 2953
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2953
uccuucacga ggaaaggaag 20
<210> 2954
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2954
uccuugcacu uucucaguuc 20
<210> 2955
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2955
uccuuuccuc gugaaggaua 20
<210> 2956
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2956
ucgaaagaca cugggugggu 20
<210> 2957
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2957
ucgagaacug ccauugucgu 20
<210> 2958
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2958
ucgagguggg uuuguaccuu 20
<210> 2959
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2959
ucgauauuca cgaucacggc 20
<210> 2960
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2960
ucgaucaugg cucacugcaa 20
<210> 2961
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2961
ucgccaugcc uggccagagg 20
<210> 2962
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2962
ucgccggccu uguuuuauuc 20
<210> 2963
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2963
ucgccguguu acuguugcac 20
<210> 2964
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2964
ucgcuuuguu gcucaggccu 20
<210> 2965
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2965
ucggaaauga ucuggcugaa 20
<210> 2966
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2966
ucggacagug cccaugcaau 20
<210> 2967
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2967
ucggagcacg uaaaugcguc 20
<210> 2968
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2968
ucgggaggau gggcaccagg 20
<210> 2969
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2969
ucggggcccu guguaggggg 20
<210> 2970
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2970
ucggggguga cagggcaaag 20
<210> 2971
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2971
ucggugccac cacggauuca 20
<210> 2972
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2972
ucgucuuuau guccgcccac 20
<210> 2973
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2973
ucgugaagga uaagagaaac 20
<210> 2974
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2974
ucgugaauau cgagaacugc 20
<210> 2975
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2975
ucgugagcua ugauuaugcc 20
<210> 2976
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2976
ucgugugugu ugggauggga 20
<210> 2977
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2977
ucguugaugg guauguguuu 20
<210> 2978
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2978
ucguuugacg ggacuucagg 20
<210> 2979
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2979
ucuaagccaa accccuaaac 20
<210> 2980
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2980
ucuagcaagg cuugcauaga 20
<210> 2981
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2981
ucuauacagu gguuuaaaaa 20
<210> 2982
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2982
ucuaugcaaa ugccuccaag 20
<210> 2983
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2983
ucuaugcaag ccuugcuaga 20
<210> 2984
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2984
ucuauuuauu uuugcaaacc 20
<210> 2985
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2985
ucucaggaag gguucugggc 20
<210> 2986
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2986
ucucaggcac uuaauaaaua 20
<210> 2987
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2987
ucucaguuca gaguuguaca 20
<210> 2988
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2988
ucuccaccgu gacacaaucc 20
<210> 2989
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2989
ucuccaggaa guuuugaguu 20
<210> 2990
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2990
ucucccaaaa agcguugcac 20
<210> 2991
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2991
ucucccagaa gccacucaua 20
<210> 2992
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2992
ucuccggaca ucagugcaac 20
<210> 2993
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2993
ucuccuugca cuuucucagu 20
<210> 2994
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2994
ucucgauauu cacgaucacg 20
<210> 2995
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2995
ucucgcuuug uugcucaggc 20
<210> 2996
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2996
ucucggggcc cuguguaggg 20
<210> 2997
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2997
ucucggugcc accacggauu 20
<210> 2998
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2998
ucucuaagcc aaaccccuaa 20
<210> 2999
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 2999
ucucuccacc gugacacaau 20
<210> 3000
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3000
ucucuccagg aaguuuugag 20
<210> 3001
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3001
ucucuccgga caucagugca 20
<210> 3002
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3002
ucucugggcc ugacaucccc 20
<210> 3003
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3003
ucucuguccc cggcauucau 20
<210> 3004
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3004
ucucugucuu ugaauaaaac 20
<210> 3005
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3005
ucucuuaaaa aaugaauuug 20
<210> 3006
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3006
ucucuuaucc uucacgagga 20
<210> 3007
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3007
ucugaaauag ggucuucauc 20
<210> 3008
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3008
ucugaaaucg ccguguuacu 20
<210> 3009
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3009
ucugaaaugc cucuucuuua 20
<210> 3010
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3010
ucugaacuga gaaagugcaa 20
<210> 3011
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3011
ucugacggag gcugucacug 20
<210> 3012
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3012
ucugccuccc agaugaauaa 20
<210> 3013
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3013
ucugccucug ggaaguggca 20
<210> 3014
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3014
ucugccugga gucccguccc 20
<210> 3015
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3015
ucugcuguug uguguugaaa 20
<210> 3016
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3016
ucuggaggau gacguggcgu 20
<210> 3017
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3017
ucuggaucgu uugacgggac 20
<210> 3018
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3018
ucuggcaggc aaugcuuugg 20
<210> 3019
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3019
ucuggccaaa uucauuuuuu 20
<210> 3020
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3020
ucuggccagg cauggcgagg 20
<210> 3021
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3021
ucuggcugaa uccguggugg 20
<210> 3022
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3022
ucugggaagu ggcaucauuu 20
<210> 3023
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3023
ucugggagau gggugucacu 20
<210> 3024
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3024
ucugggaggc agaacaggcu 20
<210> 3025
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3025
ucugggcagg gacgggacuc 20
<210> 3026
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3026
ucugggccug acauccccuc 20
<210> 3027
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3027
ucugguuucg gagcacguaa 20
<210> 3028
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3028
ucuguacagg gacgcauuua 20
<210> 3029
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3029
ucuguccccg gcauucauug 20
<210> 3030
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3030
ucugucgugu guguugggau 20
<210> 3031
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3031
ucugucuuug aauaaaacaa 20
<210> 3032
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3032
ucuuaaaaaa ugaauuuggc 20
<210> 3033
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3033
ucuuauccuu cacgaggaaa 20
<210> 3034
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3034
ucuucacgcg ggagucugac 20
<210> 3035
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3035
ucuuccaugu uugaggauug 20
<210> 3036
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3036
ucuuccuuuc cucgugaagg 20
<210> 3037
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3037
ucuucuaugc aagccuugcu 20
<210> 3038
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3038
ucuucucugu cuuugaauaa 20
<210> 3039
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3039
ucuugucguu gauggguaug 20
<210> 3040
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3040
ucuuuauguc cgcccaccua 20
<210> 3041
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3041
ucuuucgagg uggguuugua 20
<210> 3042
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3042
ucuuucugaa aucgccgugu 20
<210> 3043
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3043
ucuuugaaua aaacaaggcc 20
<210> 3044
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3044
ucuuuguaca uaaagaagag 20
<210> 3045
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3045
ugaaagccac uugcuucucu 20
<210> 3046
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3046
ugaaagggga ggggauguca 20
<210> 3047
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3047
ugaaaucgcc guguuacugu 20
<210> 3048
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3048
ugaaaugccu cuucuuuaug 20
<210> 3049
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3049
ugaacaaaua cagcaaccag 20
<210> 3050
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3050
ugaacaucug ccuggagucc 20
<210> 3051
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3051
ugaacucaag ugauccagcu 20
<210> 3052
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3052
ugaacugaga aagugcaagg 20
<210> 3053
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3053
ugaagacccu auuucagaaa 20
<210> 3054
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3054
ugaagauguc acaagggauu 20
<210> 3055
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3055
ugaaggauaa gagaaacagg 20
<210> 3056
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3056
ugaagucccg gucaaccugc 20
<210> 3057
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3057
ugaagucccg ucaaacgauc 20
<210> 3058
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3058
ugaauaaaac aaggccggcg 20
<210> 3059
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3059
ugaauaucga gaacugccau 20
<210> 3060
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3060
ugaaucccuu uccuggcuua 20
<210> 3061
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3061
ugaauccgug guggcaccga 20
<210> 3062
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3062
ugaaugaguu uggucucggu 20
<210> 3063
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3063
ugaaugccgg ggacagagag 20
<210> 3064
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3064
ugaauggcuu ggaggcauuu 20
<210> 3065
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3065
ugaauuuggc cagacacagg 20
<210> 3066
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3066
ugacacaauc cucaaacaug 20
<210> 3067
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3067
ugacacccau cucccagaag 20
<210> 3068
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3068
ugacaccucc auuucucucc 20
<210> 3069
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3069
ugacacgggc uuucccuggc 20
<210> 3070
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3070
ugacagccac accugggugc 20
<210> 3071
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3071
ugacagccuc cgucagacuc 20
<210> 3072
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3072
ugacagggca aaggcuaacc 20
<210> 3073
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3073
ugacaucccc uccccuuuca 20
<210> 3074
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3074
ugacaucuuc acgcgggagu 20
<210> 3075
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3075
ugaccaguga cucaggcucu 20
<210> 3076
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3076
ugacccaccc agugucuuuc 20
<210> 3077
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3077
ugaccgggac uucaaagccg 20
<210> 3078
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3078
ugacggaggc ugucacuguc 20
<210> 3079
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3079
ugacgggacu ucagguucuu 20
<210> 3080
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3080
ugacguggcg ugaacaucug 20
<210> 3081
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3081
ugacuauucu cggggcccug 20
<210> 3082
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3082
ugacucaggc ucugccucug 20
<210> 3083
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3083
ugacuccuga guuuaggggu 20
<210> 3084
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3084
ugagaaagug caaggagacc 20
<210> 3085
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3085
ugagacaccc gguuaccuug 20
<210> 3086
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3086
ugagaccucg ccggccuugu 20
<210> 3087
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3087
ugagcaacaa agcgagaucc 20
<210> 3088
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3088
ugagccacug cgcccggccu 20
<210> 3089
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3089
ugagcuauga uuaugccacu 20
<210> 3090
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3090
ugagcucagg cauuugaggc 20
<210> 3091
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3091
ugagcuggau cacuugaguu 20
<210> 3092
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3092
ugaggacacg uggccugcac 20
<210> 3093
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3093
ugaggauugu gucacggugg 20
<210> 3094
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3094
ugaggcaccu gugucuggcc 20
<210> 3095
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3095
ugaggcaggg ccaggggguc 20
<210> 3096
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3096
ugaggcuguc gugagcuaug 20
<210> 3097
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3097
ugagucacug gucacccuua 20
<210> 3098
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3098
ugaguggcuu cugggagaug 20
<210> 3099
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3099
ugaguucagg aguuggagac 20
<210> 3100
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3100
ugaguuuagg gguuuggcuu 20
<210> 3101
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3101
ugaguuucuc uccaccguga 20
<210> 3102
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3102
ugaguuuggu cucggugcca 20
<210> 3103
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3103
ugauaagccu uucugguuuc 20
<210> 3104
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3104
ugaucacagu aagacauuca 20
<210> 3105
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3105
ugauccagcu cagccuccca 20
<210> 3106
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3106
ugaucgugaa uaucgagaac 20
<210> 3107
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3107
ugaucuggcu gaauccgugg 20
<210> 3108
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3108
ugaugccacu ucccagaggc 20
<210> 3109
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3109
ugauggguau guguuuaaaa 20
<210> 3110
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3110
ugaugucccc guuguaugua 20
<210> 3111
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3111
ugauguccgg agagacagug 20
<210> 3112
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3112
ugauuaugcc acugcuuucc 20
<210> 3113
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3113
ugauucgggg gugacagggc 20
<210> 3114
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3114
ugcaaacaua acaaaaaauc 20
<210> 3115
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3115
ugcaaacccu gguugcugua 20
<210> 3116
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3116
ugcaaaugcc uccaagccau 20
<210> 3117
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3117
ugcaacagua acacggcgau 20
<210> 3118
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3118
ugcaacgcuu uuugggagaa 20
<210> 3119
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3119
ugcaagccuu gcuagacagc 20
<210> 3120
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3120
ugcaaggaga ccacgggaau 20
<210> 3121
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3121
ugcaauggcu uggguuggga 20
<210> 3122
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3122
ugcacacagu ccaguucgug 20
<210> 3123
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3123
ugcacgaacu ggacugugug 20
<210> 3124
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3124
ugcacgguga ggccgggcgc 20
<210> 3125
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3125
ugcacugaug uccggagaga 20
<210> 3126
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3126
ugcacuguuu ucugucgugu 20
<210> 3127
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3127
ugcacuuucu caguucagag 20
<210> 3128
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3128
ugcacuuugu auauugguug 20
<210> 3129
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3129
ugcaggccac guguccucac 20
<210> 3130
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3130
ugcagggaac cgugauaagc 20
<210> 3131
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3131
ugcauagaag agguaaacac 20
<210> 3132
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3132
ugcauagaag uggaagcacu 20
<210> 3133
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3133
ugcaucagca gcccauggcc 20
<210> 3134
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3134
ugcaugggca cuguccgaag 20
<210> 3135
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3135
ugcauggugc aucagcagcc 20
<210> 3136
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3136
ugcauguuuu aaacacauac 20
<210> 3137
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3137
ugccaaaugu acacagugua 20
<210> 3138
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3138
ugccaauccc uugugacauc 20
<210> 3139
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3139
ugccaccacg gauucagcca 20
<210> 3140
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3140
ugccaccgua cccagcugau 20
<210> 3141
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3141
ugccacuucc cagaggcaga 20
<210> 3142
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3142
ugccaucugc uguugugugu 20
<210> 3143
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3143
ugccauuguc gucuuuaugu 20
<210> 3144
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3144
ugcccagaac ccuuccugag 20
<210> 3145
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3145
ugcccaggcu ggaaagcagu 20
<210> 3146
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3146
ugcccauccu cccgaccccu 20
<210> 3147
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3147
ugcccaugca auggcuuggg 20
<210> 3148
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3148
ugccccucuc uguccccggc 20
<210> 3149
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3149
ugcccuguca cccccgaauc 20
<210> 3150
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3150
ugccucaucc accaaucucu 20
<210> 3151
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3151
ugccuccaag ccauucacuu 20
<210> 3152
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3152
ugccucccag augaauaaau 20
<210> 3153
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3153
ugccucuggg aaguggcauc 20
<210> 3154
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3154
ugccucuucu uuauguacaa 20
<210> 3155
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3155
ugccugagac acccgguuac 20
<210> 3156
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3156
ugccugccag agcuuuguuu 20
<210> 3157
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3157
ugccuggagu cccgucccug 20
<210> 3158
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3158
ugccuggcca gaggccaugg 20
<210> 3159
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3159
ugcgcccggc cucaccgugc 20
<210> 3160
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3160
ugcgucccug uacagauagu 20
<210> 3161
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3161
ugcuagacag ccagguuagc 20
<210> 3162
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3162
ugcucaggcc uggucuccaa 20
<210> 3163
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3163
ugcuccgaaa ccagaaaggc 20
<210> 3164
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3164
ugcugaugca ccaugcaugg 20
<210> 3165
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3165
ugcuguauuu guucagugac 20
<210> 3166
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3166
ugcuguugug uguugaaagc 20
<210> 3167
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3167
ugcuuccacu ucuaugcaaa 20
<210> 3168
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3168
ugcuucucug ggccugacau 20
<210> 3169
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3169
ugcuuuccag ccugggcaac 20
<210> 3170
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3170
ugcuuugguc uucucugucu 20
<210> 3171
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3171
uggaaagcag uggcauaauc 20
<210> 3172
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3172
uggaagauga aaggggaggg 20
<210> 3173
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3173
uggaagcacu aggugggcgg 20
<210> 3174
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3174
uggaaguggg uaggggucgg 20
<210> 3175
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3175
uggacugugu gcaacgcuuu 20
<210> 3176
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3176
uggagaccag gccugagcaa 20
<210> 3177
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3177
uggagagaaa cucaaaacuu 20
<210> 3178
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3178
uggaggauga cguggcguga 20
<210> 3179
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3179
uggaggcauu ugcauagaag 20
<210> 3180
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3180
uggagguguc auccuggucc 20
<210> 3181
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3181
uggagguugc agugagccau 20
<210> 3182
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3182
uggagucccg ucccugccca 20
<210> 3183
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3183
uggaucguuu gacgggacuu 20
<210> 3184
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3184
uggaugaggc agggccaggg 20
<210> 3185
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3185
uggcaauugu ccccagggac 20
<210> 3186
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3186
uggcaccaac gggacccccu 20
<210> 3187
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3187
uggcaccgag accaaacuca 20
<210> 3188
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3188
uggcaggcaa ugcuuugguc 20
<210> 3189
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3189
uggcaguucu cgauauucac 20
<210> 3190
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3190
uggcaucauu uggugaauga 20
<210> 3191
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3191
uggcauuugu guuauuauuu 20
<210> 3192
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3192
uggccaaauu cauuuuuuaa 20
<210> 3193
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3193
uggccagaca caggugccuc 20
<210> 3194
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3194
uggccagagg ccaugggcug 20
<210> 3195
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3195
uggccaggca uggcgaggcu 20
<210> 3196
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3196
uggcccugcc ucauccacca 20
<210> 3197
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3197
uggccgugag gacacguggc 20
<210> 3198
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3198
uggccucugg ccaggcaugg 20
<210> 3199
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3199
uggccugcac ccaggugugg 20
<210> 3200
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3200
uggccuggga ucccauccca 20
<210> 3201
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3201
uggcgaggcu gaggugggag 20
<210> 3202
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3202
uggcgucgga aaugaucugg 20
<210> 3203
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3203
uggcgugaac aucugccugg 20
<210> 3204
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3204
uggcugaauc cgugguggca 20
<210> 3205
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3205
uggcugucua gcaaggcuug 20
<210> 3206
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3206
uggcuuaagg aagguacaaa 20
<210> 3207
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3207
uggcuuagag auugguggau 20
<210> 3208
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3208
uggcuucugg gagaugggug 20
<210> 3209
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3209
uggcuuggag gcauuugcau 20
<210> 3210
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3210
uggcuugggu ugggauuuug 20
<210> 3211
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3211
uggcuuucaa cacacaacag 20
<210> 3212
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3212
ugggaagugg caucauuugg 20
<210> 3213
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3213
ugggagaaug auguccccgu 20
<210> 3214
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3214
ugggagaugg gugucacuuu 20
<210> 3215
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3215
ugggaggaug guuugagcuc 20
<210> 3216
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3216
ugggaggcag aacaggcuuc 20
<210> 3217
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3217
ugggaggcug agcuggauca 20
<210> 3218
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3218
ugggauccca ggccagggaa 20
<210> 3219
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3219
ugggauccca ucccaacaca 20
<210> 3220
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3220
ugggaucucg cuuuguugcu 20
<210> 3221
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3221
ugggauggga ucccaggcca 20
<210> 3222
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3222
ugggauuaca ggcgugaggc 20
<210> 3223
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3223
ugggauuuug guuucuuccu 20
<210> 3224
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3224
ugggcaccag gcuggugucc 20
<210> 3225
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3225
ugggcacugu ccgaagccug 20
<210> 3226
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3226
ugggcaggga cgggacucca 20
<210> 3227
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3227
ugggccugac auccccuccc 20
<210> 3228
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3228
ugggcggaca uaaagacgac 20
<210> 3229
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3229
ugggcugcug augcaccaug 20
<210> 3230
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3230
uggggaagug aauggcuugg 20
<210> 3231
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3231
uggggacaau ugccaauccc 20
<210> 3232
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3232
uggggauuuu uuguuauguu 20
<210> 3233
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3233
uggguacggu ggcacgugcc 20
<210> 3234
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3234
uggguagggg ucgggaggau 20
<210> 3235
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3235
uggguaugug uuuaaaacau 20
<210> 3236
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3236
ugggucauga uucgggggug 20
<210> 3237
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3237
ugggugcagg ccacgugucc 20
<210> 3238
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3238
uggguggguc augauucggg 20
<210> 3239
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3239
ugggugucac uuuuuaaacc 20
<210> 3240
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3240
uggguuggga uuuugguuuc 20
<210> 3241
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3241
uggguuugua ccuuccuuaa 20
<210> 3242
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3242
uggucacccu uaauauuuau 20
<210> 3243
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3243
uggucagucu ggaggaugac 20
<210> 3244
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3244
uggucccccc gggccuguuu 20
<210> 3245
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3245
uggucucggu gccaccacgg 20
<210> 3246
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3246
uggucuucuc ugucuuugaa 20
<210> 3247
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3247
uggugaauga guuuggucuc 20
<210> 3248
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3248
uggugcauca gcagcccaug 20
<210> 3249
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3249
uggugccauc ugcuguugug 20
<210> 3250
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3250
uggugcccau ccucccgacc 20
<210> 3251
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3251
ugguggauga ggcagggcca 20
<210> 3252
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3252
ugguggcacc gagaccaaac 20
<210> 3253
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3253
ugguguccug acagccacac 20
<210> 3254
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3254
ugguugcugu auuuguucag 20
<210> 3255
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3255
ugguuuaaaa agugacaccc 20
<210> 3256
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3256
ugguuucgga gcacguaaau 20
<210> 3257
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3257
ugguuucuuc cuuuccucgu 20
<210> 3258
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3258
ugguuugagc ucaggcauuu 20
<210> 3259
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3259
ugguuuuugu agagauggga 20
<210> 3260
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3260
uguacaaaga uuauuugcac 20
<210> 3261
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3261
uguacaacuc ugaacugaga 20
<210> 3262
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3262
uguacacagu guacaacucu 20
<210> 3263
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3263
uguacagaua guggggauuu 20
<210> 3264
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3264
uguacaggga cgcauuuacg 20
<210> 3265
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3265
uguacauaaa gaagaggcau 20
<210> 3266
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3266
uguaccuucc uuaagccagg 20
<210> 3267
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3267
uguagccuga augucuuacu 20
<210> 3268
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3268
uguagggggu uauugccucu 20
<210> 3269
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3269
uguauagaag guuuuuguag 20
<210> 3270
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3270
uguauauugg uugaaacugu 20
<210> 3271
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3271
uguaugagug gcuucuggga 20
<210> 3272
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3272
uguauguaug aguggcuucu 20
<210> 3273
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3273
uguauuucug aaauaggguc 20
<210> 3274
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3274
uguauuuguu cagugacuau 20
<210> 3275
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3275
ugucaaugaa ugccggggac 20
<210> 3276
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3276
ugucacaagg gauuggcaau 20
<210> 3277
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3277
ugucaccccc gaaucaugac 20
<210> 3278
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3278
ugucacggug gagagaaacu 20
<210> 3279
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3279
ugucacuguc ucuccggaca 20
<210> 3280
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3280
ugucacuuuu uaaaccacug 20
<210> 3281
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3281
ugucaggaca ccagccuggu 20
<210> 3282
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3282
ugucaggccc agagaagcaa 20
<210> 3283
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3283
ugucauccug guccccccgg 20
<210> 3284
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3284
uguccccagg gacaaaacac 20
<210> 3285
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3285
uguccccggc auucauugac 20
<210> 3286
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3286
uguccccguu guauguauga 20
<210> 3287
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3287
ugucccuggg gacaauugcc 20
<210> 3288
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3288
uguccgaagc cuguucugcc 20
<210> 3289
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3289
uguccgccca ccuagugcuu 20
<210> 3290
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3290
uguccggaga gacagugaca 20
<210> 3291
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3291
uguccucacg gccaagguaa 20
<210> 3292
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3292
uguccugaca gccacaccug 20
<210> 3293
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3293
ugucgucuuu auguccgccc 20
<210> 3294
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3294
ugucgugugu guugggaugg 20
<210> 3295
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3295
ugucguugau ggguaugugu 20
<210> 3296
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3296
ugucuagcaa ggcuugcaua 20
<210> 3297
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3297
ugucucuccg gacaucagug 20
<210> 3298
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3298
ugucuggcca aauucauuuu 20
<210> 3299
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3299
ugucuuucga gguggguuug 20
<210> 3300
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3300
ugucuuugaa uaaaacaagg 20
<210> 3301
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3301
ugugacaucu ucacgcggga 20
<210> 3302
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3302
ugugcaacgc uuuuugggag 20
<210> 3303
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3303
uguggcuguc aggacaccag 20
<210> 3304
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3304
uguguacauu uggcauuugu 20
<210> 3305
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3305
uguguagggg guuauugccu 20
<210> 3306
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3306
ugugucacgg uggagagaaa 20
<210> 3307
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3307
ugugucuggc caaauucauu 20
<210> 3308
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3308
ugugugcaac gcuuuuuggg 20
<210> 3309
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3309
uguguguuga aagccacuug 20
<210> 3310
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3310
uguguguugg gaugggaucc 20
<210> 3311
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3311
uguguugaaa gccacuugcu 20
<210> 3312
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3312
uguguuggga ugggauccca 20
<210> 3313
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3313
uguguuuaaa acaugcacgg 20
<210> 3314
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3314
uguuacuguu gcacugaugu 20
<210> 3315
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3315
uguuauguuu gcacuuugua 20
<210> 3316
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3316
uguucacgcc acgucauccu 20
<210> 3317
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3317
uguucaguga cuauucucgg 20
<210> 3318
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3318
uguucugccu cccagaugaa 20
<210> 3319
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3319
uguugaaagc cacuugcuuc 20
<210> 3320
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3320
uguugcacug auguccggag 20
<210> 3321
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3321
uguugcucag gccuggucuc 20
<210> 3322
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3322
uguugggaug ggaucccagg 20
<210> 3323
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3323
uguugugugu ugaaagccac 20
<210> 3324
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3324
uguuuaaaac augcacggug 20
<210> 3325
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3325
uguuuaccuc uucuaugcaa 20
<210> 3326
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3326
uguuucucuu auccuucacg 20
<210> 3327
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3327
uguuugagga uugugucacg 20
<210> 3328
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3328
uguuugcacu uuguauauug 20
<210> 3329
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3329
uguuuuaaac acauacccau 20
<210> 3330
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3330
uguuuuauuc aaagacagag 20
<210> 3331
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3331
uguuuugucc cuggggacaa 20
<210> 3332
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3332
uuaaaaaaug aauuuggcca 20
<210> 3333
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3333
uuaaaaagug acacccaucu 20
<210> 3334
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3334
uuaaaaauca gcuggguacg 20
<210> 3335
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3335
uuaaaacaug cacggugagg 20
<210> 3336
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3336
uuaaacacau acccaucaac 20
<210> 3337
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3337
uuaaaccacu guauagaagg 20
<210> 3338
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3338
uuaagccagg aaagggauuc 20
<210> 3339
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3339
uuaaggaagg uacaaaccca 20
<210> 3340
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3340
uuaaggguga ccagugacuc 20
<210> 3341
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3341
uuaauaaaua uuaaggguga 20
<210> 3342
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3342
uuaauugauc acaguaagac 20
<210> 3343
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3343
uuacaggcgu gaggcaccug 20
<210> 3344
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3344
uuaccucuuc uaugcaagcc 20
<210> 3345
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3345
uuaccuuggc cgugaggaca 20
<210> 3346
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3346
uuacgugcuc cgaaaccaga 20
<210> 3347
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3347
uuacuauguu gcccaggcug 20
<210> 3348
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3348
uuacuguugc acugaugucc 20
<210> 3349
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3349
uuagagauug guggaugagg 20
<210> 3350
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3350
uuagccuuug cccugucacc 20
<210> 3351
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3351
uuagggguuu ggcuuagaga 20
<210> 3352
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3352
uuauauauuu auucaucugg 20
<210> 3353
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3353
uuaucacggu ucccugcacu 20
<210> 3354
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3354
uuauccuuca cgaggaaagg 20
<210> 3355
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3355
uuaugccacu gcuuuccagc 20
<210> 3356
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3356
uuauguccgc ccaccuagug 20
<210> 3357
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3357
uuauuaagug ccugagacac 20
<210> 3358
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3358
uuauuauuuu gcacuguuuu 20
<210> 3359
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3359
uuauucaaag acagagaaga 20
<210> 3360
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3360
uuauucaucu gggaggcaga 20
<210> 3361
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3361
uuauugccuc ugaaaugccu 20
<210> 3362
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3362
uuauuugcac gaacuggacu 20
<210> 3363
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3363
uuauuuugca cuguuuucug 20
<210> 3364
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3364
uuauuuuugc aaacccuggu 20
<210> 3365
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3365
uucaaagaca gagaagacca 20
<210> 3366
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3366
uucaaagccg ugaucgugaa 20
<210> 3367
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3367
uucaacacac aacagcagau 20
<210> 3368
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3368
uucaaccaau auacaaagug 20
<210> 3369
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3369
uucaccaaau gaugccacuu 20
<210> 3370
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3370
uucacgagga aaggaagaaa 20
<210> 3371
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3371
uucacgauca cggcuuugaa 20
<210> 3372
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3372
uucacgccac gucauccucc 20
<210> 3373
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3373
uucacgcggg agucugacgg 20
<210> 3374
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3374
uucacuuccc caaucuuguc 20
<210> 3375
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3375
uucagaaaga accugaaguc 20
<210> 3376
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3376
uucagaggca auaacccccu 20
<210> 3377
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3377
uucagaguug uacacugugu 20
<210> 3378
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3378
uucagccaga ucauuuccga 20
<210> 3379
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3379
uucaggaguu ggagaccagg 20
<210> 3380
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3380
uucaggcuac aaaaaccuuc 20
<210> 3381
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3381
uucagguucu uucugaaauc 20
<210> 3382
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3382
uucagugacu auucucgggg 20
<210> 3383
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3383
uucaucuggg aggcagaaca 20
<210> 3384
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3384
uucauggcgu cggaaaugau 20
<210> 3385
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3385
uucauugaca cgggcuuucc 20
<210> 3386
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3386
uucauuuuuu aagagauggg 20
<210> 3387
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3387
uuccacuucu augcaaaugc 20
<210> 3388
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3388
uuccauguuu gaggauugug 20
<210> 3389
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3389
uuccauuccc guggucuccu 20
<210> 3390
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3390
uucccagagg cagagccuga 20
<210> 3391
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3391
uuccccaauc uugucguuga 20
<210> 3392
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3392
uucccuggcc ugggauccca 20
<210> 3393
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3393
uuccgacgcc augaaucccu 20
<210> 3394
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3394
uuccucguga aggauaagag 20
<210> 3395
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3395
uuccugagac cucgccggcc 20
<210> 3396
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3396
uuccuggaga gaaauggagg 20
<210> 3397
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3397
uuccuggcuu aaggaaggua 20
<210> 3398
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3398
uuccuuaagc caggaaaggg 20
<210> 3399
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3399
uuccuuuccu cgugaaggau 20
<210> 3400
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3400
uucgaggugg guuuguaccu 20
<210> 3401
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3401
uucggacagu gcccaugcaa 20
<210> 3402
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3402
uucggagcac guaaaugcgu 20
<210> 3403
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3403
uucgggggug acagggcaaa 20
<210> 3404
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3404
uucuauacag ugguuuaaaa 20
<210> 3405
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3405
uucuaugcaa augccuccaa 20
<210> 3406
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3406
uucuaugcaa gccuugcuag 20
<210> 3407
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3407
uucucaguuc agaguuguac 20
<210> 3408
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3408
uucucccaaa aagcguugca 20
<210> 3409
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3409
uucucgauau ucacgaucac 20
<210> 3410
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3410
uucucggggc ccuguguagg 20
<210> 3411
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3411
uucucuccac cgugacacaa 20
<210> 3412
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3412
uucucuccag gaaguuuuga 20
<210> 3413
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3413
uucucugggc cugacauccc 20
<210> 3414
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3414
uucucugucu uugaauaaaa 20
<210> 3415
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3415
uucucuuauc cuucacgagg 20
<210> 3416
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3416
uucugaaaua gggucuucau 20
<210> 3417
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3417
uucugaaauc gccguguuac 20
<210> 3418
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3418
uucugccucc cagaugaaua 20
<210> 3419
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3419
uucugggaga ugggugucac 20
<210> 3420
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3420
uucugggcag ggacgggacu 20
<210> 3421
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3421
uucugguuuc ggagcacgua 20
<210> 3422
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3422
uucugucgug uguguuggga 20
<210> 3423
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3423
uucuuccuuu ccucgugaag 20
<210> 3424
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3424
uucuuucuga aaucgccgug 20
<210> 3425
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3425
uugaaagcca cuugcuucuc 20
<210> 3426
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3426
uugaaguccc ggucaaccug 20
<210> 3427
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3427
uugaauaaaa caaggccggc 20
<210> 3428
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3428
uugacacggg cuuucccugg 20
<210> 3429
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3429
uugaccggga cuucaaagcc 20
<210> 3430
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3430
uugacgggac uucagguucu 20
<210> 3431
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3431
uugacuccug aguuuagggg 20
<210> 3432
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3432
uugagcucag gcauuugagg 20
<210> 3433
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3433
uugaggauug ugucacggug 20
<210> 3434
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3434
uugaggcugu cgugagcuau 20
<210> 3435
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3435
uugaguuucu cuccaccgug 20
<210> 3436
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3436
uugaucacag uaagacauuc 20
<210> 3437
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3437
uugaugggua uguguuuaaa 20
<210> 3438
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3438
uugcaaaccc ugguugcugu 20
<210> 3439
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3439
uugcacacag uccaguucgu 20
<210> 3440
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3440
uugcacgaac uggacugugu 20
<210> 3441
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3441
uugcacugau guccggagag 20
<210> 3442
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3442
uugcacuuuc ucaguucaga 20
<210> 3443
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3443
uugcacuuug uauauugguu 20
<210> 3444
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3444
uugcauagaa gagguaaaca 20
<210> 3445
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3445
uugcauagaa guggaagcac 20
<210> 3446
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3446
uugcaugggc acuguccgaa 20
<210> 3447
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3447
uugccaaucc cuugugacau 20
<210> 3448
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3448
uugcccuguc acccccgaau 20
<210> 3449
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3449
uugccucuga aaugccucuu 20
<210> 3450
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3450
uugccugcca gagcuuuguu 20
<210> 3451
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3451
uugcuagaca gccagguuag 20
<210> 3452
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3452
uugcucaggc cuggucucca 20
<210> 3453
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3453
uugcuguauu uguucaguga 20
<210> 3454
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3454
uugcuucucu gggccugaca 20
<210> 3455
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3455
uuggagacca ggccugagca 20
<210> 3456
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3456
uuggaggcau uugcauagaa 20
<210> 3457
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3457
uuggcaauug uccccaggga 20
<210> 3458
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3458
uuggcauuug uguuauuauu 20
<210> 3459
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3459
uuggccagac acaggugccu 20
<210> 3460
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3460
uuggccguga ggacacgugg 20
<210> 3461
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3461
uuggcuuaga gauuggugga 20
<210> 3462
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3462
uugggagaau gauguccccg 20
<210> 3463
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3463
uugggaggcu gagcuggauc 20
<210> 3464
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3464
uugggauggg aucccaggcc 20
<210> 3465
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3465
uugggauuuu gguuucuucc 20
<210> 3466
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3466
uuggggaagu gaauggcuug 20
<210> 3467
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3467
uuggguuggg auuuugguuu 20
<210> 3468
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3468
uuggucucgg ugccaccacg 20
<210> 3469
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3469
uuggucuucu cugucuuuga 20
<210> 3470
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3470
uuggugaaug aguuuggucu 20
<210> 3471
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3471
uuggugccau cugcuguugu 20
<210> 3472
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3472
uugguggaug aggcagggcc 20
<210> 3473
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3473
uugguuucuu ccuuuccucg 20
<210> 3474
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3474
uugguuuuug uagagauggg 20
<210> 3475
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3475
uuguacacug uguacauuug 20
<210> 3476
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3476
uuguacauaa agaagaggca 20
<210> 3477
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3477
uuguaccuuc cuuaagccag 20
<210> 3478
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3478
uuguagccug aaugucuuac 20
<210> 3479
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3479
uuguauguau gaguggcuuc 20
<210> 3480
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3480
uuguauuucu gaaauagggu 20
<210> 3481
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3481
uuguccccag ggacaaaaca 20
<210> 3482
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3482
uugucccugg ggacaauugc 20
<210> 3483
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3483
uugucgucuu uauguccgcc 20
<210> 3484
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3484
uugucguuga uggguaugug 20
<210> 3485
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3485
uugugacauc uucacgcggg 20
<210> 3486
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3486
uugugucacg guggagagaa 20
<210> 3487
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3487
uuguguguug aaagccacuu 20
<210> 3488
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3488
uuguucagug acuauucucg 20
<210> 3489
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3489
uuguugcuca ggccuggucu 20
<210> 3490
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3490
uuguuuuauu caaagacaga 20
<210> 3491
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3491
uuuaaaaagu gacacccauc 20
<210> 3492
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3492
uuuaaaacau gcacggugag 20
<210> 3493
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3493
uuuaaacaca uacccaucaa 20
<210> 3494
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3494
uuuaccucuu cuaugcaagc 20
<210> 3495
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3495
uuuacgugcu ccgaaaccag 20
<210> 3496
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3496
uuuagggguu uggcuuagag 20
<210> 3497
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3497
uuuauauauu uauucaucug 20
<210> 3498
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3498
uuuauguccg cccaccuagu 20
<210> 3499
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3499
uuuauuaagu gccugagaca 20
<210> 3500
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3500
uuuauucaaa gacagagaag 20
<210> 3501
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3501
uuuauucauc ugggaggcag 20
<210> 3502
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3502
uuuauuuuug caaacccugg 20
<210> 3503
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3503
uuucaacaca caacagcaga 20
<210> 3504
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3504
uuucaaccaa uauacaaagu 20
<210> 3505
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3505
uuucagaaag aaccugaagu 20
<210> 3506
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3506
uuucagaggc aauaaccccc 20
<210> 3507
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3507
uuucaucuuc cauguuugag 20
<210> 3508
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3508
uuucccuggc cugggauccc 20
<210> 3509
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3509
uuuccgacgc caugaauccc 20
<210> 3510
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3510
uuuccucgug aaggauaaga 20
<210> 3511
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3511
uuuccuggcu uaaggaaggu 20
<210> 3512
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3512
uuucgaggug gguuuguacc 20
<210> 3513
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3513
uuucggagca cguaaaugcg 20
<210> 3514
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3514
uuucucaguu cagaguugua 20
<210> 3515
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3515
uuucucucca ccgugacaca 20
<210> 3516
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3516
uuucucucca ggaaguuuug 20
<210> 3517
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3517
uuucucuuau ccuucacgag 20
<210> 3518
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3518
uuucugaaau agggucuuca 20
<210> 3519
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3519
uuucugaaau cgccguguua 20
<210> 3520
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3520
uuucugguuu cggagcacgu 20
<210> 3521
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3521
uuucugucgu guguguuggg 20
<210> 3522
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3522
uuucuuccuu uccucgugaa 20
<210> 3523
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3523
uuugaagucc cggucaaccu 20
<210> 3524
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3524
uuugaauaaa acaaggccgg 20
<210> 3525
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3525
uuugacggga cuucagguuc 20
<210> 3526
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3526
uuugagcuca ggcauuugag 20
<210> 3527
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3527
uuugaggauu gugucacggu 20
<210> 3528
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3528
uuugaggcug ucgugagcua 20
<210> 3529
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3529
uuugaguuuc ucuccaccgu 20
<210> 3530
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3530
uuugcaaacc cugguugcug 20
<210> 3531
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3531
uuugcacgaa cuggacugug 20
<210> 3532
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3532
uuugcacugu uuucugucgu 20
<210> 3533
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3533
uuugcacuuu guauauuggu 20
<210> 3534
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3534
uuugcauaga aguggaagca 20
<210> 3535
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3535
uuugcccugu cacccccgaa 20
<210> 3536
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3536
uuuggccaga cacaggugcc 20
<210> 3537
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3537
uuuggcuuag agauuggugg 20
<210> 3538
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3538
uuugggagaa ugaugucccc 20
<210> 3539
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3539
uuugggaggc ugagcuggau 20
<210> 3540
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3540
uuuggucucg gugccaccac 20
<210> 3541
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3541
uuuggucuuc ucugucuuug 20
<210> 3542
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3542
uuuggugaau gaguuugguc 20
<210> 3543
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3543
uuugguuucu uccuuuccuc 20
<210> 3544
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3544
uuuguacaua aagaagaggc 20
<210> 3545
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3545
uuuguaccuu ccuuaagcca 20
<210> 3546
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3546
uuuguagccu gaaugucuua 20
<210> 3547
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3547
uuugucccug gggacaauug 20
<210> 3548
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3548
uuuguucagu gacuauucuc 20
<210> 3549
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3549
uuuguugcuc aggccugguc 20
<210> 3550
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3550
uuuuaaacac auacccauca 20
<210> 3551
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3551
uuuuauucaa agacagagaa 20
<210> 3552
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3552
uuuucugucg uguguguugg 20
<210> 3553
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3553
uuuugaguuu cucuccaccg 20
<210> 3554
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3554
uuuugcaaac ccugguugcu 20
<210> 3555
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3555
uuuugcacug uuuucugucg 20
<210> 3556
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3556
uuuugggaga augauguccc 20
<210> 3557
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3557
uuuugguuuc uuccuuuccu 20
<210> 3558
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3558
uuuugguuuu uguagagaug 20
<210> 3559
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3559
uuuuguagcc ugaaugucuu 20
<210> 3560
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3560
uuuugucccu ggggacaauu 20
<210> 3561
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3561
uuuuugcaaa cccugguugc 20
<210> 3562
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3562
uuuuugggag aaugaugucc 20
<210> 3563
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3563
uuuuugguuu uuguagagau 20
<210> 3564
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3564
uuuuuguagc cugaaugucu 20
<210> 3565
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3565
aaaaaaccau gcauggugca u 21
<210> 3566
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3566
aaaaaauccc cacuaucugu a 21
<210> 3567
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3567
aaaaaaugaa uuuggccaga c 21
<210> 3568
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3568
aaaaaccaug cauggugcau c 21
<210> 3569
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3569
aaaaagcguu gcacacaguc c 21
<210> 3570
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3570
aaaaagugac acccaucucc c 21
<210> 3571
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3571
aaaaaguuaa aaaucagcug g 21
<210> 3572
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3572
aaaaaucagc uggguacggu g 21
<210> 3573
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3573
aaaaaucccc acuaucugua c 21
<210> 3574
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3574
aaaaaugaau uuggccagac a 21
<210> 3575
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3575
aaaacaaagc ucuggcaggc a 21
<210> 3576
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3576
aaaacaaggc cggcgagguc u 21
<210> 3577
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3577
aaaacaugca cggugaggcc g 21
<210> 3578
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3578
aaaaccaugc auggugcauc a 21
<210> 3579
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3579
aaaacuuccu ggagagaaau g 21
<210> 3580
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3580
aaaagcguug cacacagucc a 21
<210> 3581
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3581
aaaagugaca cccaucuccc a 21
<210> 3582
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3582
aaaaguuaaa aaucagcugg g 21
<210> 3583
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3583
aaaaucagcu ggguacggug g 21
<210> 3584
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3584
aaaaucccaa cccaagccau u 21
<210> 3585
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3585
aaaaucccca cuaucuguac a 21
<210> 3586
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3586
aaaaugaauu uggccagaca c 21
<210> 3587
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3587
aaacaaagcu cuggcaggca a 21
<210> 3588
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3588
aaacaaggcc ggcgaggucu c 21
<210> 3589
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3589
aaacacauac ccaucaacga c 21
<210> 3590
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3590
aaacacguug acuccugagu u 21
<210> 3591
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3591
aaacaggccc ggggggacca g 21
<210> 3592
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3592
aaacaugcac ggugaggccg g 21
<210> 3593
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3593
aaacauggaa gaugaaaggg g 21
<210> 3594
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3594
aaaccaaaaa guuaaaaauc a 21
<210> 3595
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3595
aaaccaaaau cccaacccaa g 21
<210> 3596
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3596
aaaccacugu auagaagguu u 21
<210> 3597
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3597
aaaccagaaa ggcuuaucac g 21
<210> 3598
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3598
aaaccauccu cccaccucag c 21
<210> 3599
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3599
aaaccaugca uggugcauca g 21
<210> 3600
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3600
aaacccaccu cgaaagacac u 21
<210> 3601
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3601
aaaccccuaa acucaggagu c 21
<210> 3602
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3602
aaacccuggu ugcuguauuu g 21
<210> 3603
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3603
aaacgaucca gacuggagga u 21
<210> 3604
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3604
aaacucaaaa cuuccuggag a 21
<210> 3605
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3605
aaacucagga gucaacgugu u 21
<210> 3606
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3606
aaacucauuc accaaaugau g 21
<210> 3607
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3607
aaacuuccug gagagaaaug g 21
<210> 3608
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3608
aaagaaccug aagucccguc a 21
<210> 3609
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3609
aaagaagagg cauuucagag g 21
<210> 3610
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3610
aaagacacug ggugggucau g 21
<210> 3611
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3611
aaagacagag aagaccaaag c 21
<210> 3612
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3612
aaagacgaca auggcaguuc u 21
<210> 3613
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3613
aaagauuauu ugcacgaacu g 21
<210> 3614
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3614
aaagcagugg cauaaucaua g 21
<210> 3615
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3615
aaagcauugc cugccagagc u 21
<210> 3616
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3616
aaagccacuu gcuucucugg g 21
<210> 3617
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3617
aaagcccgug ucaaugaaug c 21
<210> 3618
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3618
aaagccguga ucgugaauau c 21
<210> 3619
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3619
aaagcgagau cccaucucua c 21
<210> 3620
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3620
aaagcguugc acacagucca g 21
<210> 3621
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3621
aaagcucugg caggcaaugc u 21
<210> 3622
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3622
aaaggaagaa accaaaaucc c 21
<210> 3623
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3623
aaaggcuaac cuggcugucu a 21
<210> 3624
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3624
aaaggcuuau cacgguuccc u 21
<210> 3625
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3625
aaagggauuc auggcgucgg a 21
<210> 3626
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3626
aaaggggagg ggaugucagg c 21
<210> 3627
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3627
aaagugacac ccaucuccca g 21
<210> 3628
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3628
aaagugcaaa cauaacaaaa a 21
<210> 3629
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3629
aaagugcaag gagaccacgg g 21
<210> 3630
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3630
aaaguuaaaa aucagcuggg u 21
<210> 3631
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3631
aaauaaauaa auccuccagu c 21
<210> 3632
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3632
aaauaaaucc uccagucugg a 21
<210> 3633
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3633
aaauacagca accaggguuu g 21
<210> 3634
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3634
aaauauauaa aacaaagcuc u 21
<210> 3635
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3635
aaauauuaag ggugaccagu g 21
<210> 3636
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3636
aaaucagcug gguacggugg c 21
<210> 3637
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3637
aaaucccaac ccaagccauu g 21
<210> 3638
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3638
aaauccccac uaucuguaca g 21
<210> 3639
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3639
aaauccucca gucuggaucg u 21
<210> 3640
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3640
aaaucgccgu guuacuguug c 21
<210> 3641
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3641
aaaugaauuu ggccagacac a 21
<210> 3642
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3642
aaaugaucug gcugaauccg u 21
<210> 3643
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3643
aaaugaugcc acuucccaga g 21
<210> 3644
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3644
aaaugccaaa uguacacagu g 21
<210> 3645
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3645
aaaugccucc aagccauuca c 21
<210> 3646
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3646
aaaugccuga gcucaaacca u 21
<210> 3647
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3647
aaaugcgucc cuguacagau a 21
<210> 3648
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3648
aaauggaggu gucauccugg u 21
<210> 3649
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3649
aaauguacac aguguacaac u 21
<210> 3650
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3650
aacaaaaaau ccccacuauc u 21
<210> 3651
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3651
aacaaagcuc uggcaggcaa u 21
<210> 3652
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3652
aacaaauaca gcaaccaggg u 21
<210> 3653
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3653
aacaaggccg gcgaggucuc a 21
<210> 3654
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3654
aacacaaaug ccaaauguac a 21
<210> 3655
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3655
aacacacaac agcagauggc a 21
<210> 3656
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3656
aacacacacg acagaaaaca g 21
<210> 3657
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3657
aacacauacc caucaacgac a 21
<210> 3658
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3658
aacacggcga uuucagaaag a 21
<210> 3659
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3659
aacacguuga cuccugaguu u 21
<210> 3660
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3660
aacagaugaa gacccuauuu c 21
<210> 3661
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3661
aacagcagau ggcaccaacg g 21
<210> 3662
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3662
aacaggcccg gggggaccag g 21
<210> 3663
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3663
aacaggcuuc ggacagugcc c 21
<210> 3664
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3664
aacaguaaca cggcgauuuc a 21
<210> 3665
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3665
aacaguuuca accaauauac a 21
<210> 3666
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3666
aacauaacaa aaaaucccca c 21
<210> 3667
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3667
aacaucugcc uggagucccg u 21
<210> 3668
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3668
aacaugcacg gugaggccgg g 21
<210> 3669
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3669
aacauggaag augaaagggg a 21
<210> 3670
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3670
aaccaaaaag uuaaaaauca g 21
<210> 3671
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3671
aaccaaaauc ccaacccaag c 21
<210> 3672
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3672
aaccacugua uagaagguuu u 21
<210> 3673
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3673
aaccagaaag gcuuaucacg g 21
<210> 3674
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3674
aaccauccuc ccaccucagc c 21
<210> 3675
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3675
aaccaugcau ggugcaucag c 21
<210> 3676
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3676
aacccaagcc auugcauggg c 21
<210> 3677
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3677
aacccaccuc gaaagacacu g 21
<210> 3678
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3678
aacccccuac acagggcccc g 21
<210> 3679
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3679
aaccccuaaa cucaggaguc a 21
<210> 3680
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3680
aacccugguu gcuguauuug u 21
<210> 3681
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3681
aacccuuccu gagaccucgc c 21
<210> 3682
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3682
aaccgggugu cucaggcacu u 21
<210> 3683
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3683
aaccgugaua agccuuucug g 21
<210> 3684
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3684
aaccugaagu cccgucaaac g 21
<210> 3685
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3685
aaccugcccc ucucuguccc c 21
<210> 3686
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3686
aaccuggcug ucuagcaagg c 21
<210> 3687
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3687
aacgacaaga uuggggaagu g 21
<210> 3688
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3688
aacgauccag acuggaggau u 21
<210> 3689
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3689
aacgcuuuuu gggagaauga u 21
<210> 3690
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3690
aacgggaccc ccuggcccug c 21
<210> 3691
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3691
aacggggaca ucauucuccc a 21
<210> 3692
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3692
aacguguuua ccucuucuau g 21
<210> 3693
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3693
aacucaaaac uuccuggaga g 21
<210> 3694
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3694
aacucaagug auccagcuca g 21
<210> 3695
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3695
aacucaggag ucaacguguu u 21
<210> 3696
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3696
aacucauuca ccaaaugaug c 21
<210> 3697
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3697
aacuccugaa cucaagugau c 21
<210> 3698
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3698
aacucugaac ugagaaagug c 21
<210> 3699
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3699
aacugagaaa gugcaaggag a 21
<210> 3700
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3700
aacugccauu gucgucuuua u 21
<210> 3701
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3701
aacuggacug ugugcaacgc u 21
<210> 3702
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3702
aacuuccugg agagaaaugg a 21
<210> 3703
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3703
aacuuuuugg uuuuuguaga g 21
<210> 3704
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3704
aagaaaccaa aaucccaacc c 21
<210> 3705
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3705
aagaaccuga agucccguca a 21
<210> 3706
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3706
aagaagaggc auuucagagg c 21
<210> 3707
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3707
aagacacugg gugggucaug a 21
<210> 3708
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3708
aagacagaga agaccaaagc a 21
<210> 3709
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3709
aagacauuca ggcuacaaaa a 21
<210> 3710
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3710
aagaccaaag cauugccugc c 21
<210> 3711
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3711
aagacgacaa uggcaguucu c 21
<210> 3712
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3712
aagagaaaca ggcccggggg g 21
<210> 3713
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3713
aagaggcauu ucagaggcaa u 21
<210> 3714
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3714
aagagguaaa cacguugacu c 21
<210> 3715
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3715
aagaugaaag gggaggggau g 21
<210> 3716
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3716
aagaugucac aagggauugg c 21
<210> 3717
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3717
aagauuauuu gcacgaacug g 21
<210> 3718
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3718
aagauugggg aagugaaugg c 21
<210> 3719
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3719
aagcaagugg cuuucaacac a 21
<210> 3720
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3720
aagcacuagg ugggcggaca u 21
<210> 3721
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3721
aagcaguggc auaaucauag c 21
<210> 3722
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3722
aagcauugcc ugccagagcu u 21
<210> 3723
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3723
aagccaaacc ccuaaacuca g 21
<210> 3724
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3724
aagccacuca uacauacaac g 21
<210> 3725
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3725
aagccacuug cuucucuggg c 21
<210> 3726
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3726
aagccaggaa agggauucau g 21
<210> 3727
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3727
aagccauugc augggcacug u 21
<210> 3728
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3728
aagcccgugu caaugaaugc c 21
<210> 3729
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3729
aagccgugau cgugaauauc g 21
<210> 3730
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3730
aagccuguuc ugccucccag a 21
<210> 3731
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3731
aagccuugcu agacagccag g 21
<210> 3732
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3732
aagccuuucu gguuucggag c 21
<210> 3733
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3733
aagcgagauc ccaucucuac a 21
<210> 3734
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3734
aagcguugca cacaguccag u 21
<210> 3735
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3735
aagcucuggc aggcaaugcu u 21
<210> 3736
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3736
aaggaagaaa ccaaaauccc a 21
<210> 3737
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3737
aaggaaggua caaacccacc u 21
<210> 3738
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3738
aaggagacca cgggaaugga a 21
<210> 3739
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3739
aaggauaaga gaaacaggcc c 21
<210> 3740
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3740
aaggccggcg aggucucagg a 21
<210> 3741
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3741
aaggcuaacc uggcugucua g 21
<210> 3742
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3742
aaggcuuauc acgguucccu g 21
<210> 3743
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3743
aaggcuugca uagaagaggu a 21
<210> 3744
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3744
aagggauuca uggcgucgga a 21
<210> 3745
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3745
aagggauugg caauuguccc c 21
<210> 3746
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3746
aaggggaggg gaugucaggc c 21
<210> 3747
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3747
aagggugacc agugacucag g 21
<210> 3748
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3748
aaggguucug ggcagggacg g 21
<210> 3749
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3749
aagguaaccg ggugucucag g 21
<210> 3750
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3750
aagguacaaa cccaccucga a 21
<210> 3751
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3751
aagguuuuug uagccugaau g 21
<210> 3752
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3752
aagucccggu caaccugccc c 21
<210> 3753
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3753
aagucccguc aaacgaucca g 21
<210> 3754
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3754
aagugaaugg cuuggaggca u 21
<210> 3755
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3755
aagugacacc caucucccag a 21
<210> 3756
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3756
aagugaucca gcucagccuc c 21
<210> 3757
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3757
aagugcaaac auaacaaaaa a 21
<210> 3758
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3758
aagugcaagg agaccacggg a 21
<210> 3759
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3759
aagugccuga gacacccggu u 21
<210> 3760
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3760
aaguggaagc acuagguggg c 21
<210> 3761
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3761
aaguggcauc auuuggugaa u 21
<210> 3762
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3762
aaguggcuuu caacacacaa c 21
<210> 3763
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3763
aaguggguag gggucgggag g 21
<210> 3764
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3764
aaguuaaaaa ucagcugggu a 21
<210> 3765
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3765
aaguuuugag uuucucucca c 21
<210> 3766
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3766
aauaaaacaa ggccggcgag g 21
<210> 3767
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3767
aauaaauaaa uccuccaguc u 21
<210> 3768
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3768
aauaaauauu aagggugacc a 21
<210> 3769
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3769
aauaaauccu ccagucugga u 21
<210> 3770
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3770
aauaacacaa augccaaaug u 21
<210> 3771
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3771
aauaaccccc uacacagggc c 21
<210> 3772
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3772
aauacagcaa ccaggguuug c 21
<210> 3773
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3773
aauagucacu gaacaaauac a 21
<210> 3774
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3774
aauauauaaa acaaagcucu g 21
<210> 3775
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3775
aauaucgaga acugccauug u 21
<210> 3776
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3776
aauauuaagg gugaccagug a 21
<210> 3777
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3777
aauauuuauu aagugccuga g 21
<210> 3778
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3778
aaucagcugg guacgguggc a 21
<210> 3779
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3779
aaucauagcu cacgacagcc u 21
<210> 3780
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3780
aaucaugacc cacccagugu c 21
<210> 3781
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3781
aaucccaacc caagccauug c 21
<210> 3782
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3782
aauccccacu aucuguacag g 21
<210> 3783
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3783
aaucccuugu gacaucuuca c 21
<210> 3784
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3784
aaucccuuuc cuggcuuaag g 21
<210> 3785
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3785
aauccguggu ggcaccgaga c 21
<210> 3786
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3786
aauccucaaa cauggaagau g 21
<210> 3787
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3787
aauccuccag ucuggaucgu u 21
<210> 3788
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3788
aaucgccgug uuacuguugc a 21
<210> 3789
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3789
aaucucuaag ccaaaccccu a 21
<210> 3790
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3790
aaucuugucg uugaugggua u 21
<210> 3791
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3791
aaugaaugcc ggggacagag a 21
<210> 3792
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3792
aaugaauuug gccagacaca g 21
<210> 3793
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3793
aaugaguuug gucucggugc c 21
<210> 3794
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3794
aaugaucugg cugaauccgu g 21
<210> 3795
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3795
aaugaugcca cuucccagag g 21
<210> 3796
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3796
aaugaugucc ccguuguaug u 21
<210> 3797
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3797
aaugccaaau guacacagug u 21
<210> 3798
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3798
aaugccgggg acagagaggg g 21
<210> 3799
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3799
aaugccucca agccauucac u 21
<210> 3800
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3800
aaugccugag cucaaaccau c 21
<210> 3801
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3801
aaugcguccc uguacagaua g 21
<210> 3802
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3802
aaugcuuugg ucuucucugu c 21
<210> 3803
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3803
aauggaagug gguagggguc g 21
<210> 3804
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3804
aauggaggug ucauccuggu c 21
<210> 3805
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3805
aauggcaguu cucgauauuc a 21
<210> 3806
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3806
aauggcuugg aggcauuugc a 21
<210> 3807
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3807
aauggcuugg guugggauuu u 21
<210> 3808
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3808
aauguacaca guguacaacu c 21
<210> 3809
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3809
aauugaucac aguaagacau u 21
<210> 3810
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3810
aauugccaau cccuugugac a 21
<210> 3811
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3811
aauugucccc agggacaaaa c 21
<210> 3812
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3812
aauuuggcca gacacaggug c 21
<210> 3813
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3813
acaaaaaauc cccacuaucu g 21
<210> 3814
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3814
acaaacccac cucgaaagac a 21
<210> 3815
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3815
acaaagauua uuugcacgaa c 21
<210> 3816
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3816
acaaagcucu ggcaggcaau g 21
<210> 3817
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3817
acaaauacag caaccagggu u 21
<210> 3818
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3818
acaaaugcca aauguacaca g 21
<210> 3819
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3819
acaacagcag auggcaccaa c 21
<210> 3820
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3820
acaacgggga caucauucuc c 21
<210> 3821
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3821
acaacucuga acugagaaag u 21
<210> 3822
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3822
acaagauugg ggaagugaau g 21
<210> 3823
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3823
acaaggccgg cgaggucuca g 21
<210> 3824
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3824
acaagggauu ggcaauuguc c 21
<210> 3825
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3825
acaauccuca aacauggaag a 21
<210> 3826
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3826
acaauggcag uucucgauau u 21
<210> 3827
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3827
acaauugcca aucccuugug a 21
<210> 3828
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3828
acacaaaugc caaauguaca c 21
<210> 3829
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3829
acacaacagc agauggcacc a 21
<210> 3830
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3830
acacaauccu caaacaugga a 21
<210> 3831
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3831
acacacaaca gcagauggca c 21
<210> 3832
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3832
acacacacga cagaaaacag u 21
<210> 3833
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3833
acacacgaca gaaaacagug c 21
<210> 3834
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3834
acacagggcc ccgagaauag u 21
<210> 3835
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3835
acacaggugc cucacgccug u 21
<210> 3836
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3836
acacagucca guucgugcaa a 21
<210> 3837
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3837
acacagugua caacucugaa c 21
<210> 3838
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3838
acacaguguu uugucccugg g 21
<210> 3839
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3839
acacauaccc aucaacgaca a 21
<210> 3840
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3840
acaccagccu ggugcccauc c 21
<210> 3841
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3841
acacccaucu cccagaagcc a 21
<210> 3842
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3842
acacccgguu accuuggccg u 21
<210> 3843
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3843
acaccuccau uucucuccag g 21
<210> 3844
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3844
acaccugggu gcaggccacg u 21
<210> 3845
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3845
acacgacaga aaacagugca a 21
<210> 3846
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3846
acacggcgau uucagaaaga a 21
<210> 3847
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3847
acacgggcuu ucccuggccu g 21
<210> 3848
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3848
acacguggcc ugcacccagg u 21
<210> 3849
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3849
acacguugac uccugaguuu a 21
<210> 3850
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3850
acacugggug ggucaugauu c 21
<210> 3851
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3851
acacugugua cauuuggcau u 21
<210> 3852
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3852
acagagaaga ccaaagcauu g 21
<210> 3853
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3853
acagagaggg gcagguugac c 21
<210> 3854
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3854
acagauagug gggauuuuuu g 21
<210> 3855
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3855
acagaugaag acccuauuuc a 21
<210> 3856
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3856
acagaugguc agucuggagg a 21
<210> 3857
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3857
acagcaacca ggguuugcaa a 21
<210> 3858
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3858
acagcagaug gcaccaacgg g 21
<210> 3859
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3859
acagccacac cugggugcag g 21
<210> 3860
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3860
acagccaggu uagccuuugc c 21
<210> 3861
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3861
acagccucaa augccugagc u 21
<210> 3862
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3862
acagccuccg ucagacuccc g 21
<210> 3863
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3863
acaggcacgu gccaccguac c 21
<210> 3864
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3864
acaggcccgg ggggaccagg a 21
<210> 3865
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3865
acaggcguga ggcaccugug u 21
<210> 3866
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3866
acaggcuucg gacagugccc a 21
<210> 3867
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3867
acagggacgc auuuacgugc u 21
<210> 3868
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3868
acagggcaaa ggcuaaccug g 21
<210> 3869
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3869
acagggcccc gagaauaguc a 21
<210> 3870
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3870
acaggugccu cacgccugua a 21
<210> 3871
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3871
acaguaacac ggcgauuuca g 21
<210> 3872
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3872
acaguaagac auucaggcua c 21
<210> 3873
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3873
acaguccagu ucgugcaaau a 21
<210> 3874
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3874
acagugacag ccuccgucag a 21
<210> 3875
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3875
acagugcaaa auaauaacac a 21
<210> 3876
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3876
acagugccca ugcaauggcu u 21
<210> 3877
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3877
acagugguuu aaaaagugac a 21
<210> 3878
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3878
acaguguaca acucugaacu g 21
<210> 3879
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3879
acaguguuuu gucccugggg a 21
<210> 3880
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3880
acaguuucaa ccaauauaca a 21
<210> 3881
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3881
acauaaagaa gaggcauuuc a 21
<210> 3882
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3882
acauaaagac gacaauggca g 21
<210> 3883
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3883
acauaacaaa aaauccccac u 21
<210> 3884
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3884
acauacaacg gggacaucau u 21
<210> 3885
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3885
acaucagugc aacaguaaca c 21
<210> 3886
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3886
acaucauucu cccaaaaagc g 21
<210> 3887
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3887
acauccccuc cccuuucauc u 21
<210> 3888
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3888
acaucugccu ggagucccgu c 21
<210> 3889
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3889
acaucuucac gcgggagucu g 21
<210> 3890
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3890
acaugcacgg ugaggccggg c 21
<210> 3891
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3891
acauggaaga ugaaagggga g 21
<210> 3892
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3892
acauucaggc uacaaaaacc u 21
<210> 3893
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3893
accaaaaagu uaaaaaucag c 21
<210> 3894
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3894
accaaaaucc caacccaagc c 21
<210> 3895
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3895
accaaacuca uucaccaaau g 21
<210> 3896
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3896
accaaagcau ugccugccag a 21
<210> 3897
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3897
accaaaugau gccacuuccc a 21
<210> 3898
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3898
accaacggga cccccuggcc c 21
<210> 3899
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3899
accaaucucu aagccaaacc c 21
<210> 3900
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3900
accacggauu cagccagauc a 21
<210> 3901
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3901
accacgggaa uggaaguggg u 21
<210> 3902
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3902
accacuguau agaagguuuu u 21
<210> 3903
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3903
accagaaagg cuuaucacgg u 21
<210> 3904
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3904
accagccugg ugcccauccu c 21
<210> 3905
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3905
accaggauga caccuccauu u 21
<210> 3906
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3906
accaggccug agcaacaaag c 21
<210> 3907
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3907
accaggcugg uguccugaca g 21
<210> 3908
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3908
accagugacu caggcucugc c 21
<210> 3909
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3909
accauccucc caccucagcc u 21
<210> 3910
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3910
accaugcaug gugcaucagc a 21
<210> 3911
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3911
acccaagcca uugcaugggc a 21
<210> 3912
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3912
acccacccag ugucuuucga g 21
<210> 3913
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3913
acccaccucg aaagacacug g 21
<210> 3914
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3914
acccacuucc auucccgugg u 21
<210> 3915
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3915
acccagcuga uuuuuaacuu u 21
<210> 3916
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3916
acccaggugu ggcugucagg a 21
<210> 3917
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3917
acccaguguc uuucgaggug g 21
<210> 3918
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3918
acccaucaac gacaagauug g 21
<210> 3919
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3919
acccaucucc cagaagccac u 21
<210> 3920
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3920
accccaucuc uuaaaaaaug a 21
<210> 3921
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3921
acccccgaau caugacccac c 21
<210> 3922
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3922
acccccuaca cagggccccg a 21
<210> 3923
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3923
acccccuggc ccugccucau c 21
<210> 3924
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3924
accccuaaac ucaggaguca a 21
<210> 3925
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3925
accccuaccc acuuccauuc c 21
<210> 3926
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3926
acccgguuac cuuggccgug a 21
<210> 3927
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3927
acccugguug cuguauuugu u 21
<210> 3928
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3928
acccuuaaua uuuauuaagu g 21
<210> 3929
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3929
acccuuccug agaccucgcc g 21
<210> 3930
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3930
accgagacca aacucauuca c 21
<210> 3931
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3931
accgggacuu caaagccgug a 21
<210> 3932
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3932
accggguguc ucaggcacuu a 21
<210> 3933
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3933
accguaccca gcugauuuuu a 21
<210> 3934
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3934
accgugacac aauccucaaa c 21
<210> 3935
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3935
accgugauaa gccuuucugg u 21
<210> 3936
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3936
accgugcaug uuuuaaacac a 21
<210> 3937
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3937
accuagugcu uccacuucua u 21
<210> 3938
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3938
accucagccu cgccaugccu g 21
<210> 3939
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3939
accuccauuu cucuccagga a 21
<210> 3940
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3940
accucgaaag acacugggug g 21
<210> 3941
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3941
accucgccgg ccuuguuuua u 21
<210> 3942
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3942
accucuucua ugcaagccuu g 21
<210> 3943
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3943
accugaaguc ccgucaaacg a 21
<210> 3944
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3944
accugccccu cucugucccc g 21
<210> 3945
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3945
accuggcugu cuagcaaggc u 21
<210> 3946
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3946
accugggugc aggccacgug u 21
<210> 3947
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3947
accugugucu ggccaaauuc a 21
<210> 3948
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3948
accuuccuua agccaggaaa g 21
<210> 3949
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3949
accuucuaua cagugguuua a 21
<210> 3950
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3950
accuuggccg ugaggacacg u 21
<210> 3951
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3951
acgaacugga cugugugcaa c 21
<210> 3952
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3952
acgacaagau uggggaagug a 21
<210> 3953
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3953
acgacaaugg caguucucga u 21
<210> 3954
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3954
acgacagccu caaaugccug a 21
<210> 3955
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3955
acgaggaaag gaagaaacca a 21
<210> 3956
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3956
acgaucacgg cuuugaaguc c 21
<210> 3957
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3957
acgauccaga cuggaggauu u 21
<210> 3958
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3958
acgcauuuac gugcuccgaa a 21
<210> 3959
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3959
acgccacguc auccuccaga c 21
<210> 3960
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3960
acgccaugaa ucccuuuccu g 21
<210> 3961
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3961
acgcgggagu cugacggagg c 21
<210> 3962
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3962
acgcuuuuug ggagaaugau g 21
<210> 3963
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3963
acggaggcug ucacugucuc u 21
<210> 3964
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3964
acggauucag ccagaucauu u 21
<210> 3965
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3965
acggccaagg uaaccgggug u 21
<210> 3966
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3966
acggcgauuu cagaaagaac c 21
<210> 3967
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3967
acggcuuuga agucccgguc a 21
<210> 3968
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3968
acgggaaugg aaguggguag g 21
<210> 3969
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3969
acgggacccc cuggcccugc c 21
<210> 3970
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3970
acgggacucc aggcagaugu u 21
<210> 3971
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3971
acgggacuuc agguucuuuc u 21
<210> 3972
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3972
acgggcuuuc ccuggccugg g 21
<210> 3973
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3973
acggggacau cauucuccca a 21
<210> 3974
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3974
acggugaggc cgggcgcagu g 21
<210> 3975
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3975
acgguggaga gaaacucaaa a 21
<210> 3976
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3976
acguaaaugc gucccuguac a 21
<210> 3977
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3977
acgucauccu ccagacugac c 21
<210> 3978
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3978
acgugccacc guacccagcu g 21
<210> 3979
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3979
acgugcuccg aaaccagaaa g 21
<210> 3980
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3980
acguggccug cacccaggug u 21
<210> 3981
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3981
acguggcgug aacaucugcc u 21
<210> 3982
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3982
acguguccuc acggccaagg u 21
<210> 3983
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3983
acguguuuac cucuucuaug c 21
<210> 3984
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3984
acguugacuc cugaguuuag g 21
<210> 3985
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3985
acuagguggg cggacauaaa g 21
<210> 3986
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3986
acuaucugua cagggacgca u 21
<210> 3987
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3987
acuauguugc ccaggcugga a 21
<210> 3988
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3988
acuauucucg gggcccugug u 21
<210> 3989
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3989
acucaaaacu uccuggagag a 21
<210> 3990
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3990
acucaaguga uccagcucag c 21
<210> 3991
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3991
acucaggagu caacguguuu a 21
<210> 3992
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3992
acucaggcuc ugccucuggg a 21
<210> 3993
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3993
acucauacau acaacgggga c 21
<210> 3994
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3994
acucauucac caaaugaugc c 21
<210> 3995
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3995
acuccaggca gauguucacg c 21
<210> 3996
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3996
acucccgcgu gaagauguca c 21
<210> 3997
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3997
acuccugaac ucaagugauc c 21
<210> 3998
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3998
acuccugagu uuagggguuu g 21
<210> 3999
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 3999
acucugaacu gagaaagugc a 21
<210> 4000
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4000
acugaacaaa uacagcaacc a 21
<210> 4001
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4001
acugagaaag ugcaaggaga c 21
<210> 4002
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4002
acugaugucc ggagagacag u 21
<210> 4003
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4003
acugccauug ucgucuuuau g 21
<210> 4004
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4004
acugcgcccg gccucaccgu g 21
<210> 4005
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4005
acugcuuucc agccugggca a 21
<210> 4006
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4006
acuggacugu gugcaacgcu u 21
<210> 4007
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4007
acuggguggg ucaugauucg g 21
<210> 4008
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4008
acuguauaga agguuuuugu a 21
<210> 4009
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4009
acuguccgaa gccuguucug c 21
<210> 4010
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4010
acugucucuc cggacaucag u 21
<210> 4011
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4011
acuguguaca uuuggcauuu g 21
<210> 4012
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4012
acugugugca acgcuuuuug g 21
<210> 4013
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4013
acuguugcac ugauguccgg a 21
<210> 4014
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4014
acuguuuucu gucgugugug u 21
<210> 4015
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4015
acuucaaagc cgugaucgug a 21
<210> 4016
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4016
acuucagguu cuuucugaaa u 21
<210> 4017
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4017
acuuccauuc ccguggucuc c 21
<210> 4018
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4018
acuucccaga ggcagagccu g 21
<210> 4019
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4019
acuuccccaa ucuugucguu g 21
<210> 4020
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4020
acuuccugga gagaaaugga g 21
<210> 4021
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4021
acuucuaugc aaaugccucc a 21
<210> 4022
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4022
acuugcuucu cugggccuga c 21
<210> 4023
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4023
acuuucucag uucagaguug u 21
<210> 4024
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4024
acuuugggag gcugagcugg a 21
<210> 4025
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4025
acuuuuuggu uuuuguagag a 21
<210> 4026
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4026
agaaacaggc ccggggggac c 21
<210> 4027
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4027
agaaaccaaa aucccaaccc a 21
<210> 4028
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4028
agaaacucaa aacuuccugg a 21
<210> 4029
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4029
agaaagaacc ugaagucccg u 21
<210> 4030
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4030
agaaaggcuu aucacgguuc c 21
<210> 4031
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4031
agaaagugca aggagaccac g 21
<210> 4032
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4032
agaaauggag gugucauccu g 21
<210> 4033
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4033
agaacaggcu ucggacagug c 21
<210> 4034
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4034
agaacccuuc cugagaccuc g 21
<210> 4035
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4035
agaaccugaa gucccgucaa a 21
<210> 4036
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4036
agaacugcca uugucgucuu u 21
<210> 4037
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4037
agaagaccaa agcauugccu g 21
<210> 4038
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4038
agaagaggca uuucagaggc a 21
<210> 4039
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4039
agaagaggua aacacguuga c 21
<210> 4040
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4040
agaagcaagu ggcuuucaac a 21
<210> 4041
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4041
agaagccacu cauacauaca a 21
<210> 4042
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4042
agaagguuuu uguagccuga a 21
<210> 4043
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4043
agaaguggaa gcacuaggug g 21
<210> 4044
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4044
agaauaguca cugaacaaau a 21
<210> 4045
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4045
agaaugaugu ccccguugua u 21
<210> 4046
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4046
agacacaggu gccucacgcc u 21
<210> 4047
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4047
agacacccgg uuaccuuggc c 21
<210> 4048
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4048
agacacuggg ugggucauga u 21
<210> 4049
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4049
agacagagaa gaccaaagca u 21
<210> 4050
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4050
agacagaugg ucagucugga g 21
<210> 4051
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4051
agacagccag guuagccuuu g 21
<210> 4052
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4052
agacagugac agccuccguc a 21
<210> 4053
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4053
agacauucag gcuacaaaaa c 21
<210> 4054
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4054
agaccaaacu cauucaccaa a 21
<210> 4055
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4055
agaccaaagc auugccugcc a 21
<210> 4056
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4056
agaccacggg aauggaagug g 21
<210> 4057
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4057
agaccaggcc ugagcaacaa a 21
<210> 4058
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4058
agaccucgcc ggccuuguuu u 21
<210> 4059
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4059
agacgacaau ggcaguucuc g 21
<210> 4060
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4060
agacucccgc gugaagaugu c 21
<210> 4061
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4061
agagaaacag gcccgggggg a 21
<210> 4062
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4062
agagaaacuc aaaacuuccu g 21
<210> 4063
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4063
agagaaaugg aggugucauc c 21
<210> 4064
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4064
agagaagacc aaagcauugc c 21
<210> 4065
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4065
agagaagcaa guggcuuuca a 21
<210> 4066
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4066
agagacagug acagccuccg u 21
<210> 4067
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4067
agagaggggc agguugaccg g 21
<210> 4068
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4068
agagauggga ucucgcuuug u 21
<210> 4069
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4069
agagauuggu ggaugaggca g 21
<210> 4070
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4070
agagccugag ucacugguca c 21
<210> 4071
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4071
agaggcaaua acccccuaca c 21
<210> 4072
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4072
agaggcagag ccugagucac u 21
<210> 4073
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4073
agaggcauuu cagaggcaau a 21
<210> 4074
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4074
agaggccaug ggcugcugau g 21
<210> 4075
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4075
agaggggcag guugaccggg a 21
<210> 4076
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4076
agagguaaac acguugacuc c 21
<210> 4077
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4077
agaguuguac acuguguaca u 21
<210> 4078
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4078
agaucauuuc cgacgccaug a 21
<210> 4079
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4079
agaucccauc ucuacaaaaa c 21
<210> 4080
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4080
agaugaaagg ggaggggaug u 21
<210> 4081
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4081
agaugaagac ccuauuucag a 21
<210> 4082
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4082
agauggcacc aacgggaccc c 21
<210> 4083
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4083
agaugggauc ucgcuuuguu g 21
<210> 4084
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4084
agaugggugu cacuuuuuaa a 21
<210> 4085
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4085
agauggucag ucuggaggau g 21
<210> 4086
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4086
agaugucaca agggauuggc a 21
<210> 4087
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4087
agauguucac gccacgucau c 21
<210> 4088
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4088
agauuauuug cacgaacugg a 21
<210> 4089
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4089
agauugggga agugaauggc u 21
<210> 4090
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4090
agauuggugg augaggcagg g 21
<210> 4091
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4091
agcaaccagg guuugcaaaa a 21
<210> 4092
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4092
agcaaggcuu gcauagaaga g 21
<210> 4093
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4093
agcaaguggc uuucaacaca c 21
<210> 4094
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4094
agcacguaaa ugcgucccug u 21
<210> 4095
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4095
agcacuaggu gggcggacau a 21
<210> 4096
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4096
agcacuuugg gaggcugagc u 21
<210> 4097
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4097
agcagauggc accaacggga c 21
<210> 4098
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4098
agcagcccau ggccucuggc c 21
<210> 4099
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4099
agcaguggca uaaucauagc u 21
<210> 4100
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4100
agcauugccu gccagagcuu u 21
<210> 4101
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4101
agccaaaccc cuaaacucag g 21
<210> 4102
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4102
agccacaccu gggugcaggc c 21
<210> 4103
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4103
agccacucau acauacaacg g 21
<210> 4104
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4104
agccacugcg cccggccuca c 21
<210> 4105
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4105
agccacuugc uucucugggc c 21
<210> 4106
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4106
agccagauca uuuccgacgc c 21
<210> 4107
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4107
agccaggaaa gggauucaug g 21
<210> 4108
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4108
agccagguua gccuuugccc u 21
<210> 4109
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4109
agccauucac uuccccaauc u 21
<210> 4110
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4110
agccauugca ugggcacugu c 21
<210> 4111
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4111
agcccauggc cucuggccag g 21
<210> 4112
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4112
agcccguguc aaugaaugcc g 21
<210> 4113
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4113
agccgugauc gugaauaucg a 21
<210> 4114
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4114
agccucaaau gccugagcuc a 21
<210> 4115
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4115
agccuccguc agacucccgc g 21
<210> 4116
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4116
agccucgcca ugccuggcca g 21
<210> 4117
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4117
agccugaaug ucuuacugug a 21
<210> 4118
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4118
agccugaguc acuggucacc c 21
<210> 4119
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4119
agccuggugc ccauccuccc g 21
<210> 4120
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4120
agccuguucu gccucccaga u 21
<210> 4121
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4121
agccuugcua gacagccagg u 21
<210> 4122
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4122
agccuuucug guuucggagc a 21
<210> 4123
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4123
agccuuugcc cugucacccc c 21
<210> 4124
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4124
agcgagaucc caucucuaca a 21
<210> 4125
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4125
agcguugcac acaguccagu u 21
<210> 4126
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4126
agcuaugauu augccacugc u 21
<210> 4127
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4127
agcucacgac agccucaaau g 21
<210> 4128
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4128
agcucaggca uuugaggcug u 21
<210> 4129
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4129
agcucuggca ggcaaugcuu u 21
<210> 4130
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4130
agcuggauca cuugaguuca g 21
<210> 4131
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4131
agcuggguac gguggcacgu g 21
<210> 4132
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4132
aggaaaggaa gaaaccaaaa u 21
<210> 4133
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4133
aggaaaggga uucauggcgu c 21
<210> 4134
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4134
aggaagaaac caaaauccca a 21
<210> 4135
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4135
aggaaggguu cugggcaggg a 21
<210> 4136
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4136
aggaagguac aaacccaccu c 21
<210> 4137
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4137
aggaaguuuu gaguuucucu c 21
<210> 4138
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4138
aggacaccag ccuggugccc a 21
<210> 4139
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4139
aggacacgug gccugcaccc a 21
<210> 4140
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4140
aggagaccac gggaauggaa g 21
<210> 4141
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4141
aggagucaac guguuuaccu c 21
<210> 4142
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4142
aggaguugga gaccaggccu g 21
<210> 4143
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4143
aggauaagag aaacaggccc g 21
<210> 4144
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4144
aggaugacac cuccauuucu c 21
<210> 4145
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4145
aggaugacgu ggcgugaaca u 21
<210> 4146
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4146
aggaugggca ccaggcuggu g 21
<210> 4147
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4147
aggaugguuu gagcucaggc a 21
<210> 4148
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4148
aggauugugu cacgguggag a 21
<210> 4149
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4149
aggcaauaac ccccuacaca g 21
<210> 4150
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4150
aggcaaugcu uuggucuucu c 21
<210> 4151
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4151
aggcaccugu gucuggccaa a 21
<210> 4152
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4152
aggcacgugc caccguaccc a 21
<210> 4153
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4153
aggcacuuaa uaaauauuaa g 21
<210> 4154
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4154
aggcagaaca ggcuucggac a 21
<210> 4155
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4155
aggcagagcc ugagucacug g 21
<210> 4156
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4156
aggcagaugu ucacgccacg u 21
<210> 4157
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4157
aggcagggcc aggggguccc g 21
<210> 4158
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4158
aggcauggcg aggcugaggu g 21
<210> 4159
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4159
aggcauuuca gaggcaauaa c 21
<210> 4160
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4160
aggcauuuga ggcugucgug a 21
<210> 4161
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4161
aggcauuugc auagaagugg a 21
<210> 4162
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4162
aggccacgug uccucacggc c 21
<210> 4163
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4163
aggccaggga aagcccgugu c 21
<210> 4164
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4164
aggccauggg cugcugaugc a 21
<210> 4165
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4165
aggcccagag aagcaagugg c 21
<210> 4166
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4166
aggcccgggg ggaccaggau g 21
<210> 4167
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4167
aggccggcga ggucucagga a 21
<210> 4168
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4168
aggccugagc aacaaagcga g 21
<210> 4169
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4169
aggccugguc uccaacuccu g 21
<210> 4170
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4170
aggcgugagg caccuguguc u 21
<210> 4171
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4171
aggcuaaccu ggcugucuag c 21
<210> 4172
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4172
aggcuacaaa aaccuucuau a 21
<210> 4173
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4173
aggcucugcc ucugggaagu g 21
<210> 4174
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4174
aggcugagcu ggaucacuug a 21
<210> 4175
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4175
aggcuggaaa gcaguggcau a 21
<210> 4176
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4176
aggcuggugu ccugacagcc a 21
<210> 4177
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4177
aggcugucac ugucucuccg g 21
<210> 4178
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4178
aggcuuauca cgguucccug c 21
<210> 4179
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4179
aggcuucgga cagugcccau g 21
<210> 4180
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4180
aggcuugcau agaagaggua a 21
<210> 4181
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4181
agggaaagcc cgugucaaug a 21
<210> 4182
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4182
agggaaccgu gauaagccuu u 21
<210> 4183
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4183
agggacgcau uuacgugcuc c 21
<210> 4184
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4184
agggacggga cuccaggcag a 21
<210> 4185
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4185
agggauucau ggcgucggaa a 21
<210> 4186
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4186
agggauuggc aauugucccc a 21
<210> 4187
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4187
agggcaaagg cuaaccuggc u 21
<210> 4188
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4188
agggccaggg ggucccguug g 21
<210> 4189
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4189
agggccccga gaauagucac u 21
<210> 4190
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4190
aggggagggg augucaggcc c 21
<210> 4191
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4191
aggggauguc aggcccagag a 21
<210> 4192
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4192
aggggcaggu ugaccgggac u 21
<210> 4193
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4193
aggggguccc guuggugcca u 21
<210> 4194
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4194
aggggguuau ugccucugaa a 21
<210> 4195
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4195
aggggucggg aggaugggca c 21
<210> 4196
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4196
agggguuugg cuuagagauu g 21
<210> 4197
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4197
agggugacca gugacucagg c 21
<210> 4198
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4198
aggguucugg gcagggacgg g 21
<210> 4199
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4199
agguaaacac guugacuccu g 21
<210> 4200
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4200
agguaaccgg gugucucagg c 21
<210> 4201
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4201
agguacaaac ccaccucgaa a 21
<210> 4202
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4202
aggucucagg aaggguucug g 21
<210> 4203
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4203
aggugggagg augguuugag c 21
<210> 4204
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4204
aggugggcgg acauaaagac g 21
<210> 4205
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4205
agguggguuu guaccuuccu u 21
<210> 4206
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4206
aggugucauc cugguccccc c 21
<210> 4207
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4207
agguguggcu gucaggacac c 21
<210> 4208
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4208
agguuagccu uugcccuguc a 21
<210> 4209
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4209
agguucuuuc ugaaaucgcc g 21
<210> 4210
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4210
agguugaccg ggacuucaaa g 21
<210> 4211
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4211
agguuuuugu agccugaaug u 21
<210> 4212
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4212
aguaacacgg cgauuucaga a 21
<210> 4213
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4213
aguaagacau ucaggcuaca a 21
<210> 4214
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4214
aguaagaccc caucucuuaa a 21
<210> 4215
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4215
agucaacgug uuuaccucuu c 21
<210> 4216
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4216
agucacugaa caaauacagc a 21
<210> 4217
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4217
agucacuggu cacccuuaau a 21
<210> 4218
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4218
aguccaguuc gugcaaauaa u 21
<210> 4219
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4219
agucccgguc aaccugcccc u 21
<210> 4220
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4220
agucccguca aacgauccag a 21
<210> 4221
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4221
agucccgucc cugcccagaa c 21
<210> 4222
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4222
agucugacgg aggcugucac u 21
<210> 4223
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4223
agucuggagg augacguggc g 21
<210> 4224
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4224
agucuggauc guuugacggg a 21
<210> 4225
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4225
agugaauggc uuggaggcau u 21
<210> 4226
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4226
agugacaccc aucucccaga a 21
<210> 4227
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4227
agugacagcc uccgucagac u 21
<210> 4228
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4228
agugacuauu cucggggccc u 21
<210> 4229
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4229
agugacucag gcucugccuc u 21
<210> 4230
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4230
agugauccag cucagccucc c 21
<210> 4231
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4231
agugcaaaca uaacaaaaaa u 21
<210> 4232
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4232
agugcaacag uaacacggcg a 21
<210> 4233
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4233
agugcaagga gaccacggga a 21
<210> 4234
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4234
agugcaggga accgugauaa g 21
<210> 4235
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4235
agugcccaug caauggcuug g 21
<210> 4236
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4236
agugccugag acacccgguu a 21
<210> 4237
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4237
agugcuucca cuucuaugca a 21
<210> 4238
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4238
aguggaagca cuaggugggc g 21
<210> 4239
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4239
aguggcauca uuuggugaau g 21
<210> 4240
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4240
aguggcuucu gggagauggg u 21
<210> 4241
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4241
aguggcuuuc aacacacaac a 21
<210> 4242
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4242
aguggggauu uuuuguuaug u 21
<210> 4243
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4243
aguggguagg ggucgggagg a 21
<210> 4244
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4244
agugguuuaa aaagugacac c 21
<210> 4245
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4245
aguguacaac ucugaacuga g 21
<210> 4246
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4246
agugucuuuc gagguggguu u 21
<210> 4247
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4247
aguguuuugu cccuggggac a 21
<210> 4248
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4248
aguuaaaaau cagcugggua c 21
<210> 4249
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4249
aguucagagu uguacacugu g 21
<210> 4250
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4250
aguucaggag uuggagacca g 21
<210> 4251
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4251
aguucucgau auucacgauc a 21
<210> 4252
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4252
aguuggagac caggccugag c 21
<210> 4253
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4253
aguuguacac uguguacauu u 21
<210> 4254
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4254
aguuguauuu cugaaauagg g 21
<210> 4255
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4255
aguuuagggg uuuggcuuag a 21
<210> 4256
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4256
aguuucucuc caccgugaca c 21
<210> 4257
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4257
aguuuggucu cggugccacc a 21
<210> 4258
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4258
aguuuugagu uucucuccac c 21
<210> 4259
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4259
auaaaacaaa gcucuggcag g 21
<210> 4260
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4260
auaaaacaag gccggcgagg u 21
<210> 4261
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4261
auaaagaaga ggcauuucag a 21
<210> 4262
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4262
auaaagacga caauggcagu u 21
<210> 4263
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4263
auaaauaaau ccuccagucu g 21
<210> 4264
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4264
auaaauauua agggugacca g 21
<210> 4265
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4265
auaaauccuc cagucuggau c 21
<210> 4266
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4266
auaacaaaaa auccccacua u 21
<210> 4267
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4267
auaacacaaa ugccaaaugu a 21
<210> 4268
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4268
auaacccccu acacagggcc c 21
<210> 4269
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4269
auaagagaaa caggcccggg g 21
<210> 4270
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4270
auaagccuuu cugguuucgg a 21
<210> 4271
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4271
auaaucauag cucacgacag c 21
<210> 4272
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4272
auacaacggg gacaucauuc u 21
<210> 4273
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4273
auacagcaac caggguuugc a 21
<210> 4274
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4274
auacaguggu uuaaaaagug a 21
<210> 4275
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4275
auacauacaa cggggacauc a 21
<210> 4276
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4276
auacccauca acgacaagau u 21
<210> 4277
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4277
auagaagagg uaaacacguu g 21
<210> 4278
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4278
auagaagguu uuuguagccu g 21
<210> 4279
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4279
auagaagugg aagcacuagg u 21
<210> 4280
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4280
auagcucacg acagccucaa a 21
<210> 4281
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4281
auagucacug aacaaauaca g 21
<210> 4282
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4282
auagugggga uuuuuuguua u 21
<210> 4283
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4283
auauaaaaca aagcucuggc a 21
<210> 4284
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4284
auauauaaaa caaagcucug g 21
<210> 4285
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4285
auauauuuau ucaucuggga g 21
<210> 4286
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4286
auaucgagaa cugccauugu c 21
<210> 4287
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4287
auauuaaggg ugaccaguga c 21
<210> 4288
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4288
auauucacga ucacggcuuu g 21
<210> 4289
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4289
auauuuauua agugccugag a 21
<210> 4290
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4290
auauuuauuc aucugggagg c 21
<210> 4291
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4291
aucaacgaca agauugggga a 21
<210> 4292
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4292
aucacaggca cgugccaccg u 21
<210> 4293
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4293
aucacaguaa gacauucagg c 21
<210> 4294
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4294
aucacggcuu ugaagucccg g 21
<210> 4295
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4295
aucagcagcc cauggccucu g 21
<210> 4296
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4296
aucagcuggg uacgguggca c 21
<210> 4297
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4297
aucagugcaa caguaacacg g 21
<210> 4298
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4298
aucauagcuc acgacagccu c 21
<210> 4299
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4299
aucaugaccc acccaguguc u 21
<210> 4300
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4300
aucauucucc caaaaagcgu u 21
<210> 4301
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4301
aucauuuccg acgccaugaa u 21
<210> 4302
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4302
aucauuuggu gaaugaguuu g 21
<210> 4303
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4303
auccaccaau cucuaagcca a 21
<210> 4304
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4304
aucccaacac acacgacaga a 21
<210> 4305
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4305
aucccaaccc aagccauugc a 21
<210> 4306
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4306
aucccaggcc agggaaagcc c 21
<210> 4307
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4307
aucccauccc aacacacacg a 21
<210> 4308
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4308
aucccaucuc uacaaaaacc a 21
<210> 4309
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4309
auccccacua ucuguacagg g 21
<210> 4310
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4310
auccccuccc cuuucaucuu c 21
<210> 4311
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4311
aucccuugug acaucuucac g 21
<210> 4312
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4312
aucccuuucc uggcuuaagg a 21
<210> 4313
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4313
auccguggug gcaccgagac c 21
<210> 4314
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4314
auccucaaac auggaagaug a 21
<210> 4315
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4315
auccuccagu cuggaucguu u 21
<210> 4316
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4316
auccucccac cucagccucg c 21
<210> 4317
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4317
auccucccga ccccuaccca c 21
<210> 4318
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4318
auccuggucc ccccgggccu g 21
<210> 4319
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4319
auccuucacg aggaaaggaa g 21
<210> 4320
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4320
aucgagaacu gccauugucg u 21
<210> 4321
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4321
aucgccgugu uacuguugca c 21
<210> 4322
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4322
aucgugaaua ucgagaacug c 21
<210> 4323
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4323
aucguuugac gggacuucag g 21
<210> 4324
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4324
aucucccaga agccacucau a 21
<210> 4325
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4325
aucucgcuuu guugcucagg c 21
<210> 4326
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4326
aucucuaagc caaaccccua a 21
<210> 4327
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4327
aucugccugg agucccgucc c 21
<210> 4328
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4328
aucugcuguu guguguugaa a 21
<210> 4329
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4329
aucuggcuga auccguggug g 21
<210> 4330
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4330
aucugggagg cagaacaggc u 21
<210> 4331
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4331
aucuguacag ggacgcauuu a 21
<210> 4332
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4332
aucuucacgc gggagucuga c 21
<210> 4333
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4333
aucuuccaug uuugaggauu g 21
<210> 4334
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4334
aucuugucgu ugauggguau g 21
<210> 4335
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4335
augaaagggg aggggauguc a 21
<210> 4336
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4336
augaagaccc uauuucagaa a 21
<210> 4337
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4337
augaaucccu uuccuggcuu a 21
<210> 4338
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4338
augaaugccg gggacagaga g 21
<210> 4339
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4339
augaauuugg ccagacacag g 21
<210> 4340
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4340
augacaccuc cauuucucuc c 21
<210> 4341
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4341
augacccacc cagugucuuu c 21
<210> 4342
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4342
augacguggc gugaacaucu g 21
<210> 4343
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4343
augaggcagg gccagggggu c 21
<210> 4344
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4344
augaguggcu ucugggagau g 21
<210> 4345
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4345
augaguuugg ucucggugcc a 21
<210> 4346
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4346
augaucuggc ugaauccgug g 21
<210> 4347
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4347
augaugccac uucccagagg c 21
<210> 4348
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4348
augauguccc cguuguaugu a 21
<210> 4349
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4349
augauuaugc cacugcuuuc c 21
<210> 4350
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4350
augauucggg ggugacaggg c 21
<210> 4351
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4351
augcaaaugc cuccaagcca u 21
<210> 4352
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4352
augcaagccu ugcuagacag c 21
<210> 4353
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4353
augcaauggc uuggguuggg a 21
<210> 4354
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4354
augcacggug aggccgggcg c 21
<210> 4355
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4355
augcauggug caucagcagc c 21
<210> 4356
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4356
augccaaaug uacacagugu a 21
<210> 4357
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4357
augccacuuc ccagaggcag a 21
<210> 4358
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4358
augccgggga cagagagggg c 21
<210> 4359
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4359
augccuccaa gccauucacu u 21
<210> 4360
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4360
augccugagc ucaaaccauc c 21
<210> 4361
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4361
augccuggcc agaggccaug g 21
<210> 4362
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4362
augcgucccu guacagauag u 21
<210> 4363
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4363
augcuuuggu cuucucuguc u 21
<210> 4364
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4364
auggaagaug aaaggggagg g 21
<210> 4365
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4365
auggaagugg guaggggucg g 21
<210> 4366
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4366
auggaggugu cauccugguc c 21
<210> 4367
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4367
auggcaccaa cgggaccccc u 21
<210> 4368
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4368
auggcaguuc ucgauauuca c 21
<210> 4369
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4369
auggccucug gccaggcaug g 21
<210> 4370
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4370
auggcgaggc ugagguggga g 21
<210> 4371
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4371
auggcgucgg aaaugaucug g 21
<210> 4372
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4372
auggcuugga ggcauuugca u 21
<210> 4373
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4373
auggcuuggg uugggauuuu g 21
<210> 4374
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4374
augggauccc aggccaggga a 21
<210> 4375
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4375
augggaucuc gcuuuguugc u 21
<210> 4376
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4376
augggcacca ggcugguguc c 21
<210> 4377
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4377
augggcacug uccgaagccu g 21
<210> 4378
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4378
augggcugcu gaugcaccau g 21
<210> 4379
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4379
auggguaugu guuuaaaaca u 21
<210> 4380
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4380
auggguguca cuuuuuaaac c 21
<210> 4381
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4381
auggucaguc uggaggauga c 21
<210> 4382
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4382
auggugcauc agcagcccau g 21
<210> 4383
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4383
augguuugag cucaggcauu u 21
<210> 4384
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4384
auguacaaag auuauuugca c 21
<210> 4385
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4385
auguacacag uguacaacuc u 21
<210> 4386
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4386
auguaugagu ggcuucuggg a 21
<210> 4387
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4387
augucacaag ggauuggcaa u 21
<210> 4388
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4388
augucaggcc cagagaagca a 21
<210> 4389
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4389
auguccccgu uguauguaug a 21
<210> 4390
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4390
auguccgccc accuagugcu u 21
<210> 4391
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4391
auguccggag agacagugac a 21
<210> 4392
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4392
auguguuuaa aacaugcacg g 21
<210> 4393
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4393
auguucacgc cacgucaucc u 21
<210> 4394
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4394
auguuugagg auugugucac g 21
<210> 4395
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4395
auguuuuaaa cacauaccca u 21
<210> 4396
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4396
auuaagggug accagugacu c 21
<210> 4397
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4397
auuaagugcc ugagacaccc g 21
<210> 4398
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4398
auuacaggcg ugaggcaccu g 21
<210> 4399
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4399
auuaugccac ugcuuuccag c 21
<210> 4400
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4400
auuauuugca cgaacuggac u 21
<210> 4401
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4401
auuauuuugc acuguuuucu g 21
<210> 4402
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4402
auucaaagac agagaagacc a 21
<210> 4403
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4403
auucaccaaa ugaugccacu u 21
<210> 4404
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4404
auucacgauc acggcuuuga a 21
<210> 4405
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4405
auucacuucc ccaaucuugu c 21
<210> 4406
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4406
auucagccag aucauuuccg a 21
<210> 4407
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4407
auucaggcua caaaaaccuu c 21
<210> 4408
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4408
auucaucugg gaggcagaac a 21
<210> 4409
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4409
auucauggcg ucggaaauga u 21
<210> 4410
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4410
auucauugac acgggcuuuc c 21
<210> 4411
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4411
auucccgugg ucuccuugca c 21
<210> 4412
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4412
auucgggggu gacagggcaa a 21
<210> 4413
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4413
auucucccaa aaagcguugc a 21
<210> 4414
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4414
auucucgggg cccuguguag g 21
<210> 4415
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4415
auugacacgg gcuuucccug g 21
<210> 4416
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4416
auugaucaca guaagacauu c 21
<210> 4417
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4417
auugcauggg cacuguccga a 21
<210> 4418
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4418
auugccaauc ccuugugaca u 21
<210> 4419
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4419
auugccucug aaaugccucu u 21
<210> 4420
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4420
auugccugcc agagcuuugu u 21
<210> 4421
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4421
auuggcaauu guccccaggg a 21
<210> 4422
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4422
auuggggaag ugaauggcuu g 21
<210> 4423
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4423
auugguggau gaggcagggc c 21
<210> 4424
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4424
auugucccca gggacaaaac a 21
<210> 4425
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4425
auugucgucu uuauguccgc c 21
<210> 4426
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4426
auugugucac gguggagaga a 21
<210> 4427
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4427
auuuacgugc uccgaaacca g 21
<210> 4428
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4428
auuuauuaag ugccugagac a 21
<210> 4429
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4429
auuuauucau cugggaggca g 21
<210> 4430
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4430
auuuauuuuu gcaaacccug g 21
<210> 4431
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4431
auuucagaaa gaaccugaag u 21
<210> 4432
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4432
auuucagagg caauaacccc c 21
<210> 4433
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4433
auuuccgacg ccaugaaucc c 21
<210> 4434
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4434
auuucucucc aggaaguuuu g 21
<210> 4435
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4435
auuucugaaa uagggucuuc a 21
<210> 4436
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4436
auuugaggcu gucgugagcu a 21
<210> 4437
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4437
auuugcacga acuggacugu g 21
<210> 4438
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4438
auuugcauag aaguggaagc a 21
<210> 4439
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4439
auuuggccag acacaggugc c 21
<210> 4440
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4440
auuuggugaa ugaguuuggu c 21
<210> 4441
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4441
auuuguucag ugacuauucu c 21
<210> 4442
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4442
auuuugcacu guuuucuguc g 21
<210> 4443
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4443
auuuugguuu cuuccuuucc u 21
<210> 4444
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4444
auuuuugcaa acccugguug c 21
<210> 4445
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4445
caaaaaaucc ccacuaucug u 21
<210> 4446
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4446
caaaaagcgu ugcacacagu c 21
<210> 4447
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4447
caaaaaguua aaaaucagcu g 21
<210> 4448
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4448
caaaacuucc uggagagaaa u 21
<210> 4449
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4449
caaaauccca acccaagcca u 21
<210> 4450
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4450
caaacauaac aaaaaauccc c 21
<210> 4451
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4451
caaacaugga agaugaaagg g 21
<210> 4452
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4452
caaacccacc ucgaaagaca c 21
<210> 4453
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4453
caaaccccua aacucaggag u 21
<210> 4454
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4454
caaacccugg uugcuguauu u 21
<210> 4455
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4455
caaacgaucc agacuggagg a 21
<210> 4456
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4456
caaacucauu caccaaauga u 21
<210> 4457
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4457
caaagacaga gaagaccaaa g 21
<210> 4458
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4458
caaagauuau uugcacgaac u 21
<210> 4459
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4459
caaagcauug ccugccagag c 21
<210> 4460
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4460
caaagccgug aucgugaaua u 21
<210> 4461
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4461
caaagcucug gcaggcaaug c 21
<210> 4462
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4462
caaaggcuaa ccuggcuguc u 21
<210> 4463
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4463
caaagugcaa acauaacaaa a 21
<210> 4464
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4464
caaauacagc aaccaggguu u 21
<210> 4465
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4465
caaaugaugc cacuucccag a 21
<210> 4466
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4466
caaaugccaa auguacacag u 21
<210> 4467
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4467
caaaugccuc caagccauuc a 21
<210> 4468
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4468
caaaugccug agcucaaacc a 21
<210> 4469
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4469
caaauguaca caguguacaa c 21
<210> 4470
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4470
caaauucauu uuuuaagaga u 21
<210> 4471
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4471
caacacacaa cagcagaugg c 21
<210> 4472
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4472
caacacacac gacagaaaac a 21
<210> 4473
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4473
caacagauga agacccuauu u 21
<210> 4474
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4474
caacagcaga uggcaccaac g 21
<210> 4475
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4475
caacaguaac acggcgauuu c 21
<210> 4476
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4476
caaccagggu uugcaaaaau a 21
<210> 4477
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4477
caacccaagc cauugcaugg g 21
<210> 4478
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4478
caaccugccc cucucugucc c 21
<210> 4479
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4479
caacgacaag auuggggaag u 21
<210> 4480
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4480
caacgcuuuu ugggagaaug a 21
<210> 4481
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4481
caacgggacc cccuggcccu g 21
<210> 4482
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4482
caacggggac aucauucucc c 21
<210> 4483
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4483
caacguguuu accucuucua u 21
<210> 4484
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4484
caacuccuga acucaaguga u 21
<210> 4485
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4485
caacucugaa cugagaaagu g 21
<210> 4486
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4486
caagccauuc acuuccccaa u 21
<210> 4487
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4487
caagccauug caugggcacu g 21
<210> 4488
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4488
caagccuugc uagacagcca g 21
<210> 4489
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4489
caaggagacc acgggaaugg a 21
<210> 4490
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4490
caaggccggc gaggucucag g 21
<210> 4491
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4491
caaggcuugc auagaagagg u 21
<210> 4492
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4492
caagggauug gcaauugucc c 21
<210> 4493
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4493
caagguaacc gggugucuca g 21
<210> 4494
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4494
caagugaucc agcucagccu c 21
<210> 4495
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4495
caaguggcuu ucaacacaca a 21
<210> 4496
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4496
caauaacccc cuacacaggg c 21
<210> 4497
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4497
caaucccuug ugacaucuuc a 21
<210> 4498
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4498
caauccucaa acauggaaga u 21
<210> 4499
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4499
caaucucuaa gccaaacccc u 21
<210> 4500
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4500
caaucuuguc guugaugggu a 21
<210> 4501
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4501
caaugaaugc cggggacaga g 21
<210> 4502
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4502
caaugcuuug gucuucucug u 21
<210> 4503
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4503
caauggcagu ucucgauauu c 21
<210> 4504
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4504
caauggcuug gguugggauu u 21
<210> 4505
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4505
caauugccaa ucccuuguga c 21
<210> 4506
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4506
caauuguccc cagggacaaa a 21
<210> 4507
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4507
cacaaaugcc aaauguacac a 21
<210> 4508
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4508
cacaacagca gauggcacca a 21
<210> 4509
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4509
cacaagggau uggcaauugu c 21
<210> 4510
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4510
cacaauccuc aaacauggaa g 21
<210> 4511
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4511
cacacaacag cagauggcac c 21
<210> 4512
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4512
cacacacgac agaaaacagu g 21
<210> 4513
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4513
cacacagucc aguucgugca a 21
<210> 4514
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4514
cacaccuggg ugcaggccac g 21
<210> 4515
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4515
cacacgacag aaaacagugc a 21
<210> 4516
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4516
cacaggcacg ugccaccgua c 21
<210> 4517
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4517
cacagggccc cgagaauagu c 21
<210> 4518
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4518
cacaggugcc ucacgccugu a 21
<210> 4519
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4519
cacaguaaga cauucaggcu a 21
<210> 4520
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4520
cacaguccag uucgugcaaa u 21
<210> 4521
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4521
cacaguguac aacucugaac u 21
<210> 4522
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4522
cacaguguuu ugucccuggg g 21
<210> 4523
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4523
cacauaccca ucaacgacaa g 21
<210> 4524
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4524
caccaaauga ugccacuucc c 21
<210> 4525
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4525
caccaacggg acccccuggc c 21
<210> 4526
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4526
caccaaucuc uaagccaaac c 21
<210> 4527
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4527
caccacggau ucagccagau c 21
<210> 4528
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4528
caccagccug gugcccaucc u 21
<210> 4529
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4529
caccaggcug guguccugac a 21
<210> 4530
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4530
cacccaggug uggcugucag g 21
<210> 4531
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4531
cacccagugu cuuucgaggu g 21
<210> 4532
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4532
cacccaucuc ccagaagcca c 21
<210> 4533
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4533
cacccccgaa ucaugaccca c 21
<210> 4534
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4534
cacccgguua ccuuggccgu g 21
<210> 4535
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4535
cacccuuaau auuuauuaag u 21
<210> 4536
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4536
caccgagacc aaacucauuc a 21
<210> 4537
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4537
caccguaccc agcugauuuu u 21
<210> 4538
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4538
caccgugaca caauccucaa a 21
<210> 4539
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4539
caccgugcau guuuuaaaca c 21
<210> 4540
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4540
caccuagugc uuccacuucu a 21
<210> 4541
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4541
caccucagcc ucgccaugcc u 21
<210> 4542
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4542
caccuccauu ucucuccagg a 21
<210> 4543
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4543
caccucgaaa gacacugggu g 21
<210> 4544
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4544
caccugggug caggccacgu g 21
<210> 4545
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4545
caccuguguc uggccaaauu c 21
<210> 4546
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4546
cacgaacugg acugugugca a 21
<210> 4547
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4547
cacgacagaa aacagugcaa a 21
<210> 4548
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4548
cacgacagcc ucaaaugccu g 21
<210> 4549
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4549
cacgaggaaa ggaagaaacc a 21
<210> 4550
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4550
cacgaucacg gcuuugaagu c 21
<210> 4551
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4551
cacgccacgu cauccuccag a 21
<210> 4552
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4552
cacgcgggag ucugacggag g 21
<210> 4553
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4553
cacggauuca gccagaucau u 21
<210> 4554
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4554
cacggccaag guaaccgggu g 21
<210> 4555
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4555
cacggcgauu ucagaaagaa c 21
<210> 4556
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4556
cacggcuuug aagucccggu c 21
<210> 4557
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4557
cacgggaaug gaagugggua g 21
<210> 4558
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4558
cacgggcuuu cccuggccug g 21
<210> 4559
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4559
cacggugagg ccgggcgcag u 21
<210> 4560
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4560
cacgguggag agaaacucaa a 21
<210> 4561
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4561
cacguaaaug cgucccugua c 21
<210> 4562
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4562
cacgucaucc uccagacuga c 21
<210> 4563
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4563
cacgugccac cguacccagc u 21
<210> 4564
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4564
cacguggccu gcacccaggu g 21
<210> 4565
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4565
cacguguccu cacggccaag g 21
<210> 4566
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4566
cacguugacu ccugaguuua g 21
<210> 4567
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4567
cacuaggugg gcggacauaa a 21
<210> 4568
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4568
cacuaucugu acagggacgc a 21
<210> 4569
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4569
cacucauaca uacaacgggg a 21
<210> 4570
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4570
cacugaacaa auacagcaac c 21
<210> 4571
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4571
cacugauguc cggagagaca g 21
<210> 4572
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4572
cacugcgccc ggccucaccg u 21
<210> 4573
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4573
cacugggugg gucaugauuc g 21
<210> 4574
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4574
cacuggucac ccuuaauauu u 21
<210> 4575
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4575
cacuguauag aagguuuuug u 21
<210> 4576
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4576
cacuguccga agccuguucu g 21
<210> 4577
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4577
cacugucucu ccggacauca g 21
<210> 4578
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4578
cacuguguac auuuggcauu u 21
<210> 4579
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4579
cacuguuuuc ugucgugugu g 21
<210> 4580
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4580
cacuuaauaa auauuaaggg u 21
<210> 4581
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4581
cacuuccauu cccguggucu c 21
<210> 4582
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4582
cacuucccag aggcagagcc u 21
<210> 4583
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4583
cacuucccca aucuugucgu u 21
<210> 4584
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4584
cacuucuaug caaaugccuc c 21
<210> 4585
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4585
cacuugcuuc ucugggccug a 21
<210> 4586
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4586
cacuuucuca guucagaguu g 21
<210> 4587
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4587
cacuuuggga ggcugagcug g 21
<210> 4588
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4588
cacuuuuuaa accacuguau a 21
<210> 4589
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4589
cagaaagaac cugaaguccc g 21
<210> 4590
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4590
cagaaaggcu uaucacgguu c 21
<210> 4591
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4591
cagaacaggc uucggacagu g 21
<210> 4592
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4592
cagaacccuu ccugagaccu c 21
<210> 4593
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4593
cagaagccac ucauacauac a 21
<210> 4594
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4594
cagacacagg ugccucacgc c 21
<210> 4595
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4595
cagacucccg cgugaagaug u 21
<210> 4596
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4596
cagagaagac caaagcauug c 21
<210> 4597
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4597
cagagaagca aguggcuuuc a 21
<210> 4598
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4598
cagagagggg cagguugacc g 21
<210> 4599
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4599
cagagccuga gucacugguc a 21
<210> 4600
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4600
cagaggcaau aacccccuac a 21
<210> 4601
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4601
cagaggcaga gccugaguca c 21
<210> 4602
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4602
cagaggccau gggcugcuga u 21
<210> 4603
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4603
cagaguugua cacuguguac a 21
<210> 4604
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4604
cagauagugg ggauuuuuug u 21
<210> 4605
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4605
cagaucauuu ccgacgccau g 21
<210> 4606
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4606
cagaugaaga cccuauuuca g 21
<210> 4607
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4607
cagauggcac caacgggacc c 21
<210> 4608
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4608
cagaugguca gucuggagga u 21
<210> 4609
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4609
cagauguuca cgccacguca u 21
<210> 4610
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4610
cagcaaccag gguuugcaaa a 21
<210> 4611
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4611
cagcacuuug ggaggcugag c 21
<210> 4612
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4612
cagcagaugg caccaacggg a 21
<210> 4613
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4613
cagcagccca uggccucugg c 21
<210> 4614
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4614
cagccacacc ugggugcagg c 21
<210> 4615
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4615
cagccagauc auuuccgacg c 21
<210> 4616
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4616
cagccagguu agccuuugcc c 21
<210> 4617
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4617
cagcccaugg ccucuggcca g 21
<210> 4618
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4618
cagccucaaa ugccugagcu c 21
<210> 4619
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4619
cagccuccgu cagacucccg c 21
<210> 4620
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4620
cagccucgcc augccuggcc a 21
<210> 4621
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4621
cagccuggug cccauccucc c 21
<210> 4622
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4622
cagcugggua cgguggcacg u 21
<210> 4623
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4623
caggaaaggg auucauggcg u 21
<210> 4624
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4624
caggaagggu ucugggcagg g 21
<210> 4625
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4625
caggaaguuu ugaguuucuc u 21
<210> 4626
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4626
caggacacca gccuggugcc c 21
<210> 4627
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4627
caggagucaa cguguuuacc u 21
<210> 4628
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4628
caggaguugg agaccaggcc u 21
<210> 4629
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4629
caggaugaca ccuccauuuc u 21
<210> 4630
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4630
caggcaaugc uuuggucuuc u 21
<210> 4631
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4631
caggcacgug ccaccguacc c 21
<210> 4632
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4632
caggcacuua auaaauauua a 21
<210> 4633
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4633
caggcagaug uucacgccac g 21
<210> 4634
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4634
caggcauggc gaggcugagg u 21
<210> 4635
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4635
caggcauuug aggcugucgu g 21
<210> 4636
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4636
caggccacgu guccucacgg c 21
<210> 4637
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4637
caggccaggg aaagcccgug u 21
<210> 4638
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4638
caggcccaga gaagcaagug g 21
<210> 4639
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4639
caggcccggg gggaccagga u 21
<210> 4640
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4640
caggccugag caacaaagcg a 21
<210> 4641
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4641
caggccuggu cuccaacucc u 21
<210> 4642
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4642
caggcgugag gcaccugugu c 21
<210> 4643
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4643
caggcuacaa aaaccuucua u 21
<210> 4644
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4644
caggcucugc cucugggaag u 21
<210> 4645
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4645
caggcuggaa agcaguggca u 21
<210> 4646
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4646
caggcuggug uccugacagc c 21
<210> 4647
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4647
caggcuucgg acagugccca u 21
<210> 4648
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4648
cagggaaagc ccgugucaau g 21
<210> 4649
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4649
cagggaaccg ugauaagccu u 21
<210> 4650
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4650
cagggacgca uuuacgugcu c 21
<210> 4651
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4651
cagggacggg acuccaggca g 21
<210> 4652
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4652
cagggcaaag gcuaaccugg c 21
<210> 4653
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4653
cagggccagg gggucccguu g 21
<210> 4654
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4654
cagggccccg agaauaguca c 21
<210> 4655
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4655
cagggggucc cguuggugcc a 21
<210> 4656
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4656
cagguguggc ugucaggaca c 21
<210> 4657
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4657
cagguuagcc uuugcccugu c 21
<210> 4658
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4658
cagguucuuu cugaaaucgc c 21
<210> 4659
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4659
cagguugacc gggacuucaa a 21
<210> 4660
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4660
caguaacacg gcgauuucag a 21
<210> 4661
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4661
caguaagaca uucaggcuac a 21
<210> 4662
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4662
caguccaguu cgugcaaaua a 21
<210> 4663
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4663
cagucuggag gaugacgugg c 21
<210> 4664
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4664
cagucuggau cguuugacgg g 21
<210> 4665
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4665
cagugacagc cuccgucaga c 21
<210> 4666
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4666
cagugacuau ucucggggcc c 21
<210> 4667
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4667
cagugacuca ggcucugccu c 21
<210> 4668
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4668
cagugcaaaa uaauaacaca a 21
<210> 4669
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4669
cagugcaaca guaacacggc g 21
<210> 4670
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4670
cagugcaggg aaccgugaua a 21
<210> 4671
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4671
cagugcccau gcaauggcuu g 21
<210> 4672
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4672
cagugguuua aaaagugaca c 21
<210> 4673
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4673
caguguacaa cucugaacug a 21
<210> 4674
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4674
cagugucuuu cgaggugggu u 21
<210> 4675
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4675
caguguuuug ucccugggga c 21
<210> 4676
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4676
caguucagag uuguacacug u 21
<210> 4677
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4677
caguucgugc aaauaaucuu u 21
<210> 4678
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4678
caguucucga uauucacgau c 21
<210> 4679
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4679
caguuucaac caauauacaa a 21
<210> 4680
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4680
cauaaagaag aggcauuuca g 21
<210> 4681
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4681
cauaaagacg acaauggcag u 21
<210> 4682
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4682
cauaacaaaa aauccccacu a 21
<210> 4683
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4683
cauaaucaua gcucacgaca g 21
<210> 4684
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4684
cauacaacgg ggacaucauu c 21
<210> 4685
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4685
cauacauaca acggggacau c 21
<210> 4686
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4686
cauacccauc aacgacaaga u 21
<210> 4687
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4687
cauagaagag guaaacacgu u 21
<210> 4688
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4688
cauagaagug gaagcacuag g 21
<210> 4689
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4689
cauagcucac gacagccuca a 21
<210> 4690
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4690
caucaacgac aagauugggg a 21
<210> 4691
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4691
caucagcagc ccauggccuc u 21
<210> 4692
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4692
caucagugca acaguaacac g 21
<210> 4693
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4693
caucauucuc ccaaaaagcg u 21
<210> 4694
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4694
caucauuugg ugaaugaguu u 21
<210> 4695
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4695
cauccaccaa ucucuaagcc a 21
<210> 4696
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4696
caucccaaca cacacgacag a 21
<210> 4697
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4697
cauccccucc ccuuucaucu u 21
<210> 4698
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4698
cauccuccca ccucagccuc g 21
<210> 4699
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4699
cauccucccg accccuaccc a 21
<210> 4700
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4700
cauccugguc cccccgggcc u 21
<210> 4701
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4701
caucucccag aagccacuca u 21
<210> 4702
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4702
caucucuuaa aaaaugaauu u 21
<210> 4703
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4703
caucugccug gagucccguc c 21
<210> 4704
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4704
caucugcugu uguguguuga a 21
<210> 4705
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4705
caucugggag gcagaacagg c 21
<210> 4706
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4706
caucuucacg cgggagucug a 21
<210> 4707
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4707
caucuuccau guuugaggau u 21
<210> 4708
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4708
caugaauccc uuuccuggcu u 21
<210> 4709
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4709
caugacccac ccagugucuu u 21
<210> 4710
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4710
caugauucgg gggugacagg g 21
<210> 4711
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4711
caugcaaugg cuuggguugg g 21
<210> 4712
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4712
caugcacggu gaggccgggc g 21
<210> 4713
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4713
caugcauggu gcaucagcag c 21
<210> 4714
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4714
caugccuggc cagaggccau g 21
<210> 4715
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4715
cauggaagau gaaaggggag g 21
<210> 4716
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4716
cauggccucu ggccaggcau g 21
<210> 4717
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4717
cauggcgagg cugagguggg a 21
<210> 4718
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4718
cauggcgucg gaaaugaucu g 21
<210> 4719
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4719
caugggcacu guccgaagcc u 21
<210> 4720
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4720
caugggcugc ugaugcacca u 21
<210> 4721
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4721
cauggugcau cagcagccca u 21
<210> 4722
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4722
cauguuugag gauuguguca c 21
<210> 4723
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4723
cauguuuuaa acacauaccc a 21
<210> 4724
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4724
cauucaccaa augaugccac u 21
<210> 4725
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4725
cauucacuuc cccaaucuug u 21
<210> 4726
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4726
cauucaggcu acaaaaaccu u 21
<210> 4727
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4727
cauucauuga cacgggcuuu c 21
<210> 4728
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4728
cauucccgug gucuccuugc a 21
<210> 4729
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4729
cauucuccca aaaagcguug c 21
<210> 4730
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4730
cauugacacg ggcuuucccu g 21
<210> 4731
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4731
cauugcaugg gcacuguccg a 21
<210> 4732
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4732
cauugccugc cagagcuuug u 21
<210> 4733
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4733
cauugucguc uuuauguccg c 21
<210> 4734
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4734
cauuuacgug cuccgaaacc a 21
<210> 4735
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4735
cauuucagag gcaauaaccc c 21
<210> 4736
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4736
cauuuccgac gccaugaauc c 21
<210> 4737
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4737
cauuucucuc caggaaguuu u 21
<210> 4738
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4738
cauuugaggc ugucgugagc u 21
<210> 4739
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4739
cauuugcaua gaaguggaag c 21
<210> 4740
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4740
cauuugguga augaguuugg u 21
<210> 4741
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4741
cauuuuuuaa gagauggggu c 21
<210> 4742
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4742
ccaaaaagcg uugcacacag u 21
<210> 4743
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4743
ccaaaaaguu aaaaaucagc u 21
<210> 4744
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4744
ccaaaauccc aacccaagcc a 21
<210> 4745
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4745
ccaaaccccu aaacucagga g 21
<210> 4746
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4746
ccaaacucau ucaccaaaug a 21
<210> 4747
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4747
ccaaagcauu gccugccaga g 21
<210> 4748
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4748
ccaaaugaug ccacuuccca g 21
<210> 4749
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4749
ccaaauguac acaguguaca a 21
<210> 4750
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4750
ccaaauucau uuuuuaagag a 21
<210> 4751
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4751
ccaacacaca cgacagaaaa c 21
<210> 4752
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4752
ccaacccaag ccauugcaug g 21
<210> 4753
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4753
ccaacgggac ccccuggccc u 21
<210> 4754
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4754
ccaacuccug aacucaagug a 21
<210> 4755
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4755
ccaagccauu cacuucccca a 21
<210> 4756
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4756
ccaagccauu gcaugggcac u 21
<210> 4757
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4757
ccaagguaac cgggugucuc a 21
<210> 4758
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4758
ccaaucccuu gugacaucuu c 21
<210> 4759
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4759
ccaaucucua agccaaaccc c 21
<210> 4760
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4760
ccaaucuugu cguugauggg u 21
<210> 4761
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4761
ccacaccugg gugcaggcca c 21
<210> 4762
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4762
ccaccaaucu cuaagccaaa c 21
<210> 4763
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4763
ccaccacgga uucagccaga u 21
<210> 4764
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4764
ccacccagug ucuuucgagg u 21
<210> 4765
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4765
ccaccguacc cagcugauuu u 21
<210> 4766
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4766
ccaccgugac acaauccuca a 21
<210> 4767
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4767
ccaccuagug cuuccacuuc u 21
<210> 4768
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4768
ccaccucagc cucgccaugc c 21
<210> 4769
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4769
ccaccucgaa agacacuggg u 21
<210> 4770
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4770
ccacggauuc agccagauca u 21
<210> 4771
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4771
ccacgggaau ggaagugggu a 21
<210> 4772
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4772
ccacgucauc cuccagacug a 21
<210> 4773
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4773
ccacgugucc ucacggccaa g 21
<210> 4774
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4774
ccacuaucug uacagggacg c 21
<210> 4775
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4775
ccacucauac auacaacggg g 21
<210> 4776
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4776
ccacugcgcc cggccucacc g 21
<210> 4777
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4777
ccacuguaua gaagguuuuu g 21
<210> 4778
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4778
ccacuuccau ucccgugguc u 21
<210> 4779
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4779
ccacuuccca gaggcagagc c 21
<210> 4780
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4780
ccacuucuau gcaaaugccu c 21
<210> 4781
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4781
ccacuugcuu cucugggccu g 21
<210> 4782
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4782
ccagaaaggc uuaucacggu u 21
<210> 4783
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4783
ccagaacccu uccugagacc u 21
<210> 4784
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4784
ccagaagcca cucauacaua c 21
<210> 4785
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4785
ccagacacag gugccucacg c 21
<210> 4786
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4786
ccagagaagc aaguggcuuu c 21
<210> 4787
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4787
ccagaggcag agccugaguc a 21
<210> 4788
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4788
ccagaggcca ugggcugcug a 21
<210> 4789
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4789
ccagaucauu uccgacgcca u 21
<210> 4790
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4790
ccagccuggu gcccauccuc c 21
<210> 4791
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4791
ccaggaaagg gauucauggc g 21
<210> 4792
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4792
ccaggaaguu uugaguuucu c 21
<210> 4793
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4793
ccaggaugac accuccauuu c 21
<210> 4794
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4794
ccaggcagau guucacgcca c 21
<210> 4795
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4795
ccaggcaugg cgaggcugag g 21
<210> 4796
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4796
ccaggccagg gaaagcccgu g 21
<210> 4797
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4797
ccaggccuga gcaacaaagc g 21
<210> 4798
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4798
ccaggcugga aagcaguggc a 21
<210> 4799
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4799
ccaggcuggu guccugacag c 21
<210> 4800
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4800
ccagggaaag cccgugucaa u 21
<210> 4801
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4801
ccaggggguc ccguuggugc c 21
<210> 4802
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4802
ccaggugugg cugucaggac a 21
<210> 4803
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4803
ccagguuagc cuuugcccug u 21
<210> 4804
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4804
ccagucugga ucguuugacg g 21
<210> 4805
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4805
ccagugacuc aggcucugcc u 21
<210> 4806
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4806
ccagugcagg gaaccgugau a 21
<210> 4807
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4807
ccagugucuu ucgagguggg u 21
<210> 4808
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4808
ccaguucgug caaauaaucu u 21
<210> 4809
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4809
ccaucaacga caagauuggg g 21
<210> 4810
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4810
ccaucccaac acacacgaca g 21
<210> 4811
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4811
ccauccuccc accucagccu c 21
<210> 4812
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4812
ccauccuccc gaccccuacc c 21
<210> 4813
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4813
ccaucuccca gaagccacuc a 21
<210> 4814
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4814
ccaucucuua aaaaaugaau u 21
<210> 4815
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4815
ccaucugcug uuguguguug a 21
<210> 4816
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4816
ccaugaaucc cuuuccuggc u 21
<210> 4817
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4817
ccaugcaaug gcuuggguug g 21
<210> 4818
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4818
ccaugcaugg ugcaucagca g 21
<210> 4819
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4819
ccaugccugg ccagaggcca u 21
<210> 4820
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4820
ccauggccuc uggccaggca u 21
<210> 4821
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4821
ccaugggcug cugaugcacc a 21
<210> 4822
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4822
ccauguuuga ggauuguguc a 21
<210> 4823
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4823
ccauucacuu ccccaaucuu g 21
<210> 4824
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4824
ccauucccgu ggucuccuug c 21
<210> 4825
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4825
ccauugcaug ggcacugucc g 21
<210> 4826
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4826
ccauugucgu cuuuaugucc g 21
<210> 4827
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4827
ccauuucucu ccaggaaguu u 21
<210> 4828
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4828
cccaaaaagc guugcacaca g 21
<210> 4829
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4829
cccaacacac acgacagaaa a 21
<210> 4830
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4830
cccaacccaa gccauugcau g 21
<210> 4831
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4831
cccaagccau ugcaugggca c 21
<210> 4832
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4832
cccaaucuug ucguugaugg g 21
<210> 4833
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4833
cccacccagu gucuuucgag g 21
<210> 4834
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4834
cccaccuagu gcuuccacuu c 21
<210> 4835
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4835
cccaccucag ccucgccaug c 21
<210> 4836
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4836
cccaccucga aagacacugg g 21
<210> 4837
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4837
cccacuaucu guacagggac g 21
<210> 4838
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4838
cccacuucca uucccguggu c 21
<210> 4839
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4839
cccagaaccc uuccugagac c 21
<210> 4840
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4840
cccagaagcc acucauacau a 21
<210> 4841
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4841
cccagagaag caaguggcuu u 21
<210> 4842
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4842
cccagaggca gagccugagu c 21
<210> 4843
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4843
cccagcugau uuuuaacuuu u 21
<210> 4844
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4844
cccaggccag ggaaagcccg u 21
<210> 4845
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4845
cccaggcugg aaagcagugg c 21
<210> 4846
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4846
cccagggaca aaacacugug u 21
<210> 4847
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4847
cccaggugug gcugucagga c 21
<210> 4848
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4848
cccagugcag ggaaccguga u 21
<210> 4849
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4849
cccagugucu uucgaggugg g 21
<210> 4850
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4850
cccaucaacg acaagauugg g 21
<210> 4851
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4851
cccaucccaa cacacacgac a 21
<210> 4852
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4852
cccauccucc cgaccccuac c 21
<210> 4853
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4853
cccaucuccc agaagccacu c 21
<210> 4854
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4854
cccaucucua caaaaaccaa a 21
<210> 4855
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4855
cccaucucuu aaaaaaugaa u 21
<210> 4856
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4856
cccaugcaau ggcuuggguu g 21
<210> 4857
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4857
cccauggccu cuggccaggc a 21
<210> 4858
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4858
ccccaaucuu gucguugaug g 21
<210> 4859
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4859
ccccacuauc uguacaggga c 21
<210> 4860
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4860
ccccagggac aaaacacugu g 21
<210> 4861
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4861
ccccagugca gggaaccgug a 21
<210> 4862
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4862
ccccaucucu uaaaaaauga a 21
<210> 4863
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4863
cccccagugc agggaaccgu g 21
<210> 4864
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4864
ccccccagug cagggaaccg u 21
<210> 4865
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4865
ccccccgggc cuguuucucu u 21
<210> 4866
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4866
cccccgaauc augacccacc c 21
<210> 4867
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4867
cccccgggcc uguuucucuu a 21
<210> 4868
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4868
cccccuacac agggccccga g 21
<210> 4869
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4869
cccccuggcc cugccucauc c 21
<210> 4870
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4870
ccccgaauca ugacccaccc a 21
<210> 4871
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4871
ccccgagaau agucacugaa c 21
<210> 4872
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4872
ccccggcauu cauugacacg g 21
<210> 4873
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4873
ccccgggccu guuucucuua u 21
<210> 4874
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4874
ccccguugua uguaugagug g 21
<210> 4875
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4875
ccccuaaacu caggagucaa c 21
<210> 4876
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4876
ccccuacaca gggccccgag a 21
<210> 4877
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4877
ccccuaccca cuuccauucc c 21
<210> 4878
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4878
ccccuccccu uucaucuucc a 21
<210> 4879
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4879
ccccucucug uccccggcau u 21
<210> 4880
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4880
ccccuuucau cuuccauguu u 21
<210> 4881
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4881
cccgaaucau gacccaccca g 21
<210> 4882
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4882
cccgaccccu acccacuucc a 21
<210> 4883
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4883
cccgagaaua gucacugaac a 21
<210> 4884
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4884
cccgcgugaa gaugucacaa g 21
<210> 4885
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4885
cccggcauuc auugacacgg g 21
<210> 4886
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4886
cccggccuca ccgugcaugu u 21
<210> 4887
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4887
cccgggccug uuucucuuau c 21
<210> 4888
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4888
cccgggggga ccaggaugac a 21
<210> 4889
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4889
cccggucaac cugccccucu c 21
<210> 4890
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4890
cccgguuacc uuggccguga g 21
<210> 4891
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4891
cccgucaaac gauccagacu g 21
<210> 4892
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4892
cccgucccug cccagaaccc u 21
<210> 4893
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4893
cccguggucu ccuugcacuu u 21
<210> 4894
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4894
cccgugucaa ugaaugccgg g 21
<210> 4895
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4895
cccguuggug ccaucugcug u 21
<210> 4896
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4896
cccguuguau guaugagugg c 21
<210> 4897
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4897
cccuaaacuc aggagucaac g 21
<210> 4898
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4898
cccuacacag ggccccgaga a 21
<210> 4899
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4899
cccuacccac uuccauuccc g 21
<210> 4900
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4900
cccuccccuu ucaucuucca u 21
<210> 4901
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4901
cccucucugu ccccggcauu c 21
<210> 4902
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4902
cccugcccag aacccuuccu g 21
<210> 4903
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4903
cccugccuca uccaccaauc u 21
<210> 4904
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4904
cccuggcccu gccucaucca c 21
<210> 4905
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4905
cccuggccug ggaucccauc c 21
<210> 4906
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4906
cccuggggac aauugccaau c 21
<210> 4907
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4907
cccugguugc uguauuuguu c 21
<210> 4908
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4908
cccuguacag auagugggga u 21
<210> 4909
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4909
cccugucacc cccgaaucau g 21
<210> 4910
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4910
cccuguguag gggguuauug c 21
<210> 4911
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4911
cccuuaauau uuauuaagug c 21
<210> 4912
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4912
cccuuccuga gaccucgccg g 21
<210> 4913
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4913
cccuugugac aucuucacgc g 21
<210> 4914
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4914
cccuuucauc uuccauguuu g 21
<210> 4915
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4915
cccuuuccug gcuuaaggaa g 21
<210> 4916
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4916
ccgaaaccag aaaggcuuau c 21
<210> 4917
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4917
ccgaagccug uucugccucc c 21
<210> 4918
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4918
ccgaaucaug acccacccag u 21
<210> 4919
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4919
ccgaccccua cccacuucca u 21
<210> 4920
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4920
ccgacgccau gaaucccuuu c 21
<210> 4921
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4921
ccgagaauag ucacugaaca a 21
<210> 4922
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4922
ccgagaccaa acucauucac c 21
<210> 4923
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4923
ccgcccaccu agugcuucca c 21
<210> 4924
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4924
ccgcgugaag augucacaag g 21
<210> 4925
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4925
ccggacauca gugcaacagu a 21
<210> 4926
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4926
ccggagagac agugacagcc u 21
<210> 4927
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4927
ccggcauuca uugacacggg c 21
<210> 4928
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4928
ccggccucac cgugcauguu u 21
<210> 4929
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4929
ccggccuugu uuuauucaaa g 21
<210> 4930
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4930
ccggcgaggu cucaggaagg g 21
<210> 4931
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4931
ccgggacuuc aaagccguga u 21
<210> 4932
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4932
ccgggccugu uucucuuauc c 21
<210> 4933
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4933
ccggggacag agaggggcag g 21
<210> 4934
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4934
ccggggggac caggaugaca c 21
<210> 4935
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4935
ccgggugucu caggcacuua a 21
<210> 4936
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4936
ccggucaacc ugccccucuc u 21
<210> 4937
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4937
ccgguuaccu uggccgugag g 21
<210> 4938
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4938
ccguacccag cugauuuuua a 21
<210> 4939
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4939
ccgucaaacg auccagacug g 21
<210> 4940
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4940
ccgucagacu cccgcgugaa g 21
<210> 4941
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4941
ccgucccugc ccagaacccu u 21
<210> 4942
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4942
ccgugacaca auccucaaac a 21
<210> 4943
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4943
ccgugaggac acguggccug c 21
<210> 4944
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4944
ccgugauaag ccuuucuggu u 21
<210> 4945
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4945
ccgugaucgu gaauaucgag a 21
<210> 4946
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4946
ccgugcaugu uuuaaacaca u 21
<210> 4947
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4947
ccguggucuc cuugcacuuu c 21
<210> 4948
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4948
ccgugguggc accgagacca a 21
<210> 4949
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4949
ccgugucaau gaaugccggg g 21
<210> 4950
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4950
ccguguuacu guugcacuga u 21
<210> 4951
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4951
ccguuggugc caucugcugu u 21
<210> 4952
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4952
ccguuguaug uaugaguggc u 21
<210> 4953
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4953
ccuaaacuca ggagucaacg u 21
<210> 4954
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4954
ccuacacagg gccccgagaa u 21
<210> 4955
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4955
ccuacccacu uccauucccg u 21
<210> 4956
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4956
ccuagugcuu ccacuucuau g 21
<210> 4957
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4957
ccucaaacau ggaagaugaa a 21
<210> 4958
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4958
ccucaaaugc cugagcucaa a 21
<210> 4959
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4959
ccucaccgug cauguuuuaa a 21
<210> 4960
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4960
ccucacggcc aagguaaccg g 21
<210> 4961
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4961
ccucagccuc gccaugccug g 21
<210> 4962
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4962
ccucauccac caaucucuaa g 21
<210> 4963
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4963
ccuccaagcc auucacuucc c 21
<210> 4964
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4964
ccuccagucu ggaucguuug a 21
<210> 4965
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4965
ccuccauuuc ucuccaggaa g 21
<210> 4966
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4966
ccucccaccu cagccucgcc a 21
<210> 4967
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4967
ccuccccuuu caucuuccau g 21
<210> 4968
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4968
ccucccgacc ccuacccacu u 21
<210> 4969
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4969
ccuccgucag acucccgcgu g 21
<210> 4970
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4970
ccucgaaaga cacugggugg g 21
<210> 4971
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4971
ccucgccaug ccuggccaga g 21
<210> 4972
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4972
ccucgccggc cuuguuuuau u 21
<210> 4973
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4973
ccucgugaag gauaagagaa a 21
<210> 4974
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4974
ccucucuguc cccggcauuc a 21
<210> 4975
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4975
ccucugaaau gccucuucuu u 21
<210> 4976
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4976
ccucuggcca ggcauggcga g 21
<210> 4977
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4977
ccucugggaa guggcaucau u 21
<210> 4978
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4978
ccucuucuau gcaagccuug c 21
<210> 4979
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4979
ccugaagucc cgucaaacga u 21
<210> 4980
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4980
ccugaauguc uuacugugau c 21
<210> 4981
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4981
ccugacagcc acaccugggu g 21
<210> 4982
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4982
ccugacaucc ccuccccuuu c 21
<210> 4983
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4983
ccugagacac ccgguuaccu u 21
<210> 4984
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4984
ccugagaccu cgccggccuu g 21
<210> 4985
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4985
ccugagcaac aaagcgagau c 21
<210> 4986
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4986
ccugagucac uggucacccu u 21
<210> 4987
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4987
ccugaguuua gggguuuggc u 21
<210> 4988
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4988
ccugcaccca gguguggcug u 21
<210> 4989
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4989
ccugccagag cuuuguuuua u 21
<210> 4990
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4990
ccugccccuc ucuguccccg g 21
<210> 4991
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4991
ccugccucau ccaccaaucu c 21
<210> 4992
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4992
ccuggagaga aauggaggug u 21
<210> 4993
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4993
ccuggagucc cgucccugcc c 21
<210> 4994
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4994
ccuggccaga ggccaugggc u 21
<210> 4995
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4995
ccuggcccug ccucauccac c 21
<210> 4996
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4996
ccuggccugg gaucccaucc c 21
<210> 4997
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4997
ccuggcuguc uagcaaggcu u 21
<210> 4998
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4998
ccuggcuuaa ggaagguaca a 21
<210> 4999
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 4999
ccugggaucc caucccaaca c 21
<210> 5000
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5000
ccuggggaca auugccaauc c 21
<210> 5001
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5001
ccugggugca ggccacgugu c 21
<210> 5002
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5002
ccuggucccc ccgggccugu u 21
<210> 5003
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5003
ccuggugccc auccucccga c 21
<210> 5004
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5004
ccugguugcu guauuuguuc a 21
<210> 5005
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5005
ccuguacaga uaguggggau u 21
<210> 5006
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5006
ccugucaccc ccgaaucaug a 21
<210> 5007
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5007
ccuguguagg ggguuauugc c 21
<210> 5008
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5008
ccugugucug gccaaauuca u 21
<210> 5009
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5009
ccuguucugc cucccagaug a 21
<210> 5010
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5010
ccuguuucuc uuauccuuca c 21
<210> 5011
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5011
ccuuaagcca ggaaagggau u 21
<210> 5012
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5012
ccuuaauauu uauuaagugc c 21
<210> 5013
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5013
ccuucacgag gaaaggaaga a 21
<210> 5014
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5014
ccuuccugag accucgccgg c 21
<210> 5015
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5015
ccuuccuuaa gccaggaaag g 21
<210> 5016
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5016
ccuucuauac agugguuuaa a 21
<210> 5017
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5017
ccuugcacuu ucucaguuca g 21
<210> 5018
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5018
ccuugcuaga cagccagguu a 21
<210> 5019
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5019
ccuuggccgu gaggacacgu g 21
<210> 5020
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5020
ccuugugaca ucuucacgcg g 21
<210> 5021
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5021
ccuuguuuua uucaaagaca g 21
<210> 5022
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5022
ccuuucaucu uccauguuug a 21
<210> 5023
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5023
ccuuuccucg ugaaggauaa g 21
<210> 5024
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5024
ccuuuccugg cuuaaggaag g 21
<210> 5025
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5025
ccuuucuggu uucggagcac g 21
<210> 5026
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5026
ccuuugcccu gucacccccg a 21
<210> 5027
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5027
cgaaaccaga aaggcuuauc a 21
<210> 5028
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5028
cgaaagacac uggguggguc a 21
<210> 5029
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5029
cgaacuggac ugugugcaac g 21
<210> 5030
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5030
cgaagccugu ucugccuccc a 21
<210> 5031
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5031
cgaaucauga cccacccagu g 21
<210> 5032
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5032
cgacaagauu ggggaaguga a 21
<210> 5033
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5033
cgacaauggc aguucucgau a 21
<210> 5034
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5034
cgacagaaaa cagugcaaaa u 21
<210> 5035
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5035
cgacagccuc aaaugccuga g 21
<210> 5036
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5036
cgaccccuac ccacuuccau u 21
<210> 5037
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5037
cgacgccaug aaucccuuuc c 21
<210> 5038
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5038
cgagaacugc cauugucguc u 21
<210> 5039
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5039
cgagaauagu cacugaacaa a 21
<210> 5040
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5040
cgagaccaaa cucauucacc a 21
<210> 5041
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5041
cgagauccca ucucuacaaa a 21
<210> 5042
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5042
cgaggaaagg aagaaaccaa a 21
<210> 5043
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5043
cgaggucuca ggaaggguuc u 21
<210> 5044
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5044
cgaggugggu uuguaccuuc c 21
<210> 5045
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5045
cgauauucac gaucacggcu u 21
<210> 5046
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5046
cgaucacggc uuugaagucc c 21
<210> 5047
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5047
cgauccagac uggaggauuu a 21
<210> 5048
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5048
cgauuucaga aagaaccuga a 21
<210> 5049
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5049
cgcauuuacg ugcuccgaaa c 21
<210> 5050
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5050
cgccacguca uccuccagac u 21
<210> 5051
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5051
cgccaugaau cccuuuccug g 21
<210> 5052
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5052
cgccaugccu ggccagaggc c 21
<210> 5053
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5053
cgcccaccua gugcuuccac u 21
<210> 5054
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5054
cgcccggccu caccgugcau g 21
<210> 5055
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5055
cgccggccuu guuuuauuca a 21
<210> 5056
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5056
cgccguguua cuguugcacu g 21
<210> 5057
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5057
cgcgggaguc ugacggaggc u 21
<210> 5058
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5058
cgcgugaaga ugucacaagg g 21
<210> 5059
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5059
cgcuuuguug cucaggccug g 21
<210> 5060
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5060
cgcuuuuugg gagaaugaug u 21
<210> 5061
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5061
cggaaaugau cuggcugaau c 21
<210> 5062
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5062
cggacagugc ccaugcaaug g 21
<210> 5063
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5063
cggacauaaa gacgacaaug g 21
<210> 5064
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5064
cggacaucag ugcaacagua a 21
<210> 5065
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5065
cggagagaca gugacagccu c 21
<210> 5066
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5066
cggagcacgu aaaugcgucc c 21
<210> 5067
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5067
cggaggcugu cacugucucu c 21
<210> 5068
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5068
cggauucagc cagaucauuu c 21
<210> 5069
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5069
cggcauucau ugacacgggc u 21
<210> 5070
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5070
cggccaaggu aaccgggugu c 21
<210> 5071
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5071
cggccucacc gugcauguuu u 21
<210> 5072
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5072
cggccuuguu uuauucaaag a 21
<210> 5073
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5073
cggcgagguc ucaggaaggg u 21
<210> 5074
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5074
cggcgauuuc agaaagaacc u 21
<210> 5075
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5075
cggcuuugaa gucccgguca a 21
<210> 5076
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5076
cgggaaugga aguggguagg g 21
<210> 5077
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5077
cgggaccccc uggcccugcc u 21
<210> 5078
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5078
cgggacucca ggcagauguu c 21
<210> 5079
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5079
cgggacuuca aagccgugau c 21
<210> 5080
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5080
cgggacuuca gguucuuucu g 21
<210> 5081
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5081
cgggaggaug ggcaccaggc u 21
<210> 5082
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5082
cgggagucug acggaggcug u 21
<210> 5083
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5083
cgggccuguu ucucuuaucc u 21
<210> 5084
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5084
cgggcuuucc cuggccuggg a 21
<210> 5085
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5085
cggggacaga gaggggcagg u 21
<210> 5086
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5086
cggggacauc auucucccaa a 21
<210> 5087
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5087
cggggcccug uguagggggu u 21
<210> 5088
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5088
cggggggacc aggaugacac c 21
<210> 5089
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5089
cgggggugac agggcaaagg c 21
<210> 5090
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5090
cgggugucuc aggcacuuaa u 21
<210> 5091
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5091
cggucaaccu gccccucucu g 21
<210> 5092
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5092
cggugaggcc gggcgcagug g 21
<210> 5093
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5093
cggugccacc acggauucag c 21
<210> 5094
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5094
cgguggagag aaacucaaaa c 21
<210> 5095
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5095
cgguuaccuu ggccgugagg a 21
<210> 5096
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5096
cguaaaugcg ucccuguaca g 21
<210> 5097
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5097
cguacccagc ugauuuuuaa c 21
<210> 5098
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5098
cgucaaacga uccagacugg a 21
<210> 5099
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5099
cgucagacuc ccgcgugaag a 21
<210> 5100
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5100
cgucauccuc cagacugacc a 21
<210> 5101
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5101
cgucccugcc cagaacccuu c 21
<210> 5102
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5102
cgucccugua cagauagugg g 21
<210> 5103
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5103
cgucggaaau gaucuggcug a 21
<210> 5104
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5104
cgucuuuaug uccgcccacc u 21
<210> 5105
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5105
cgugaacauc ugccuggagu c 21
<210> 5106
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5106
cgugaagaug ucacaaggga u 21
<210> 5107
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5107
cgugaaggau aagagaaaca g 21
<210> 5108
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5108
cgugaauauc gagaacugcc a 21
<210> 5109
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5109
cgugacacaa uccucaaaca u 21
<210> 5110
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5110
cgugagccac ugcgcccggc c 21
<210> 5111
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5111
cgugagcuau gauuaugcca c 21
<210> 5112
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5112
cgugaggaca cguggccugc a 21
<210> 5113
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5113
cgugaggcac cugugucugg c 21
<210> 5114
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5114
cgugauaagc cuuucugguu u 21
<210> 5115
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5115
cgugaucgug aauaucgaga a 21
<210> 5116
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5116
cgugcauguu uuaaacacau a 21
<210> 5117
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5117
cgugccaccg uacccagcug a 21
<210> 5118
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5118
cgugcuccga aaccagaaag g 21
<210> 5119
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5119
cguggccugc acccaggugu g 21
<210> 5120
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5120
cguggcguga acaucugccu g 21
<210> 5121
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5121
cguggucucc uugcacuuuc u 21
<210> 5122
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5122
cgugguggca ccgagaccaa a 21
<210> 5123
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5123
cgugucaaug aaugccgggg a 21
<210> 5124
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5124
cguguccuca cggccaaggu a 21
<210> 5125
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5125
cguguguguu gggaugggau c 21
<210> 5126
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5126
cguguuacug uugcacugau g 21
<210> 5127
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5127
cguguuuacc ucuucuaugc a 21
<210> 5128
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5128
cguugacucc ugaguuuagg g 21
<210> 5129
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5129
cguugauggg uauguguuua a 21
<210> 5130
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5130
cguugcacac aguccaguuc g 21
<210> 5131
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5131
cguuggugcc aucugcuguu g 21
<210> 5132
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5132
cguuguaugu augaguggcu u 21
<210> 5133
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5133
cguuugacgg gacuucaggu u 21
<210> 5134
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5134
cuaaacucag gagucaacgu g 21
<210> 5135
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5135
cuaaccuggc ugucuagcaa g 21
<210> 5136
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5136
cuaagccaaa ccccuaaacu c 21
<210> 5137
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5137
cuacaaaaac cuucuauaca g 21
<210> 5138
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5138
cuacacaggg ccccgagaau a 21
<210> 5139
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5139
cuacccacuu ccauucccgu g 21
<210> 5140
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5140
cuagacagcc agguuagccu u 21
<210> 5141
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5141
cuagcaaggc uugcauagaa g 21
<210> 5142
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5142
cuaggugggc ggacauaaag a 21
<210> 5143
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5143
cuagugcuuc cacuucuaug c 21
<210> 5144
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5144
cuauacagug guuuaaaaag u 21
<210> 5145
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5145
cuaucuguac agggacgcau u 21
<210> 5146
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5146
cuaugauuau gccacugcuu u 21
<210> 5147
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5147
cuaugcaaau gccuccaagc c 21
<210> 5148
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5148
cuaugcaagc cuugcuagac a 21
<210> 5149
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5149
cuauucucgg ggcccugugu a 21
<210> 5150
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5150
cuauuuauuu uugcaaaccc u 21
<210> 5151
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5151
cucaaaacuu ccuggagaga a 21
<210> 5152
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5152
cucaaacaug gaagaugaaa g 21
<210> 5153
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5153
cucaaaugcc ugagcucaaa c 21
<210> 5154
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5154
cucaagugau ccagcucagc c 21
<210> 5155
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5155
cucaccgugc auguuuuaaa c 21
<210> 5156
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5156
cucacgacag ccucaaaugc c 21
<210> 5157
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5157
cucacggcca agguaaccgg g 21
<210> 5158
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5158
cucagccucg ccaugccugg c 21
<210> 5159
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5159
cucaggaagg guucugggca g 21
<210> 5160
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5160
cucaggaguc aacguguuua c 21
<210> 5161
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5161
cucaggcacu uaauaaauau u 21
<210> 5162
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5162
cucaggcauu ugaggcuguc g 21
<210> 5163
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5163
cucaggccug gucuccaacu c 21
<210> 5164
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5164
cucaggcucu gccucuggga a 21
<210> 5165
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5165
cucaguucag aguuguacac u 21
<210> 5166
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5166
cucauacaua caacggggac a 21
<210> 5167
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5167
cucauccacc aaucucuaag c 21
<210> 5168
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5168
cucauucacc aaaugaugcc a 21
<210> 5169
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5169
cuccaagcca uucacuuccc c 21
<210> 5170
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5170
cuccaccgug acacaauccu c 21
<210> 5171
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5171
cuccaggaag uuuugaguuu c 21
<210> 5172
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5172
cuccaggcag auguucacgc c 21
<210> 5173
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5173
cuccagucug gaucguuuga c 21
<210> 5174
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5174
cuccauuucu cuccaggaag u 21
<210> 5175
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5175
cucccaaaaa gcguugcaca c 21
<210> 5176
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5176
cucccaccuc agccucgcca u 21
<210> 5177
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5177
cucccagaag ccacucauac a 21
<210> 5178
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5178
cuccccuuuc aucuuccaug u 21
<210> 5179
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5179
cucccgaccc cuacccacuu c 21
<210> 5180
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5180
cucccgcgug aagaugucac a 21
<210> 5181
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5181
cuccgaaacc agaaaggcuu a 21
<210> 5182
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5182
cuccggacau cagugcaaca g 21
<210> 5183
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5183
cuccgucaga cucccgcgug a 21
<210> 5184
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5184
cuccugaacu caagugaucc a 21
<210> 5185
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5185
cuccugaguu uagggguuug g 21
<210> 5186
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5186
cuccuugcac uuucucaguu c 21
<210> 5187
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5187
cucgaaagac acuggguggg u 21
<210> 5188
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5188
cucgauauuc acgaucacgg c 21
<210> 5189
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5189
cucgaucaug gcucacugca a 21
<210> 5190
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5190
cucgccaugc cuggccagag g 21
<210> 5191
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5191
cucgccggcc uuguuuuauu c 21
<210> 5192
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5192
cucgcuuugu ugcucaggcc u 21
<210> 5193
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5193
cucggggccc uguguagggg g 21
<210> 5194
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5194
cucggugcca ccacggauuc a 21
<210> 5195
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5195
cucgugaagg auaagagaaa c 21
<210> 5196
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5196
cucuaagcca aaccccuaaa c 21
<210> 5197
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5197
cucuccaccg ugacacaauc c 21
<210> 5198
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5198
cucuccagga aguuuugagu u 21
<210> 5199
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5199
cucuccggac aucagugcaa c 21
<210> 5200
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5200
cucucugucc ccggcauuca u 21
<210> 5201
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5201
cucugaaaug ccucuucuuu a 21
<210> 5202
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5202
cucugaacug agaaagugca a 21
<210> 5203
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5203
cucugccucu gggaaguggc a 21
<210> 5204
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5204
cucuggcagg caaugcuuug g 21
<210> 5205
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5205
cucuggccag gcauggcgag g 21
<210> 5206
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5206
cucugggaag uggcaucauu u 21
<210> 5207
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5207
cucugggccu gacauccccu c 21
<210> 5208
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5208
cucugucccc ggcauucauu g 21
<210> 5209
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5209
cucugucuuu gaauaaaaca a 21
<210> 5210
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5210
cucuuaaaaa augaauuugg c 21
<210> 5211
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5211
cucuuauccu ucacgaggaa a 21
<210> 5212
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5212
cucuucuaug caagccuugc u 21
<210> 5213
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5213
cugaaauagg gucuucaucu g 21
<210> 5214
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5214
cugaaaucgc cguguuacug u 21
<210> 5215
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5215
cugaaaugcc ucuucuuuau g 21
<210> 5216
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5216
cugaacaaau acagcaacca g 21
<210> 5217
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5217
cugaacucaa gugauccagc u 21
<210> 5218
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5218
cugaacugag aaagugcaag g 21
<210> 5219
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5219
cugaaguccc gucaaacgau c 21
<210> 5220
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5220
cugaauccgu gguggcaccg a 21
<210> 5221
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5221
cugacagcca caccugggug c 21
<210> 5222
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5222
cugacauccc cuccccuuuc a 21
<210> 5223
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5223
cugacggagg cugucacugu c 21
<210> 5224
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5224
cugagaaagu gcaaggagac c 21
<210> 5225
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5225
cugagacacc cgguuaccuu g 21
<210> 5226
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5226
cugagaccuc gccggccuug u 21
<210> 5227
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5227
cugagcaaca aagcgagauc c 21
<210> 5228
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5228
cugagcugga ucacuugagu u 21
<210> 5229
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5229
cugagucacu ggucacccuu a 21
<210> 5230
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5230
cugaguuuag ggguuuggcu u 21
<210> 5231
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5231
cugauguccg gagagacagu g 21
<210> 5232
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5232
cugcacccag guguggcugu c 21
<210> 5233
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5233
cugccauugu cgucuuuaug u 21
<210> 5234
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5234
cugcccagaa cccuuccuga g 21
<210> 5235
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5235
cugccccucu cuguccccgg c 21
<210> 5236
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5236
cugccucauc caccaaucuc u 21
<210> 5237
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5237
cugccuccca gaugaauaaa u 21
<210> 5238
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5238
cugccucugg gaaguggcau c 21
<210> 5239
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5239
cugccuggag ucccgucccu g 21
<210> 5240
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5240
cugcgcccgg ccucaccgug c 21
<210> 5241
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5241
cugcugaugc accaugcaug g 21
<210> 5242
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5242
cugcuguugu guguugaaag c 21
<210> 5243
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5243
cugcuuucca gccugggcaa c 21
<210> 5244
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5244
cuggaaagca guggcauaau c 21
<210> 5245
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5245
cuggacugug ugcaacgcuu u 21
<210> 5246
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5246
cuggagagaa auggaggugu c 21
<210> 5247
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5247
cuggaggaug acguggcgug a 21
<210> 5248
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5248
cuggaguccc gucccugccc a 21
<210> 5249
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5249
cuggaucacu ugaguucagg a 21
<210> 5250
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5250
cuggaucguu ugacgggacu u 21
<210> 5251
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5251
cuggcaggca augcuuuggu c 21
<210> 5252
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5252
cuggccaaau ucauuuuuua a 21
<210> 5253
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5253
cuggccagag gccaugggcu g 21
<210> 5254
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5254
cuggccaggc auggcgaggc u 21
<210> 5255
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5255
cuggcccugc cucauccacc a 21
<210> 5256
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5256
cuggccuggg aucccauccc a 21
<210> 5257
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5257
cuggcugaau ccgugguggc a 21
<210> 5258
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5258
cuggcugucu agcaaggcuu g 21
<210> 5259
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5259
cuggcuuaag gaagguacaa a 21
<210> 5260
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5260
cugggaagug gcaucauuug g 21
<210> 5261
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5261
cugggagaug ggugucacuu u 21
<210> 5262
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5262
cugggaggca gaacaggcuu c 21
<210> 5263
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5263
cugggauccc aucccaacac a 21
<210> 5264
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5264
cugggauuac aggcgugagg c 21
<210> 5265
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5265
cugggcaggg acgggacucc a 21
<210> 5266
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5266
cugggccuga cauccccucc c 21
<210> 5267
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5267
cuggggacaa uugccaaucc c 21
<210> 5268
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5268
cuggguacgg uggcacgugc c 21
<210> 5269
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5269
cugggugcag gccacguguc c 21
<210> 5270
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5270
cugggugggu caugauucgg g 21
<210> 5271
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5271
cuggucaccc uuaauauuua u 21
<210> 5272
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5272
cugguccccc cgggccuguu u 21
<210> 5273
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5273
cuggugccca uccucccgac c 21
<210> 5274
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5274
cugguguccu gacagccaca c 21
<210> 5275
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5275
cugguugcug uauuuguuca g 21
<210> 5276
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5276
cugguuucgg agcacguaaa u 21
<210> 5277
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5277
cuguacagau aguggggauu u 21
<210> 5278
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5278
cuguacaggg acgcauuuac g 21
<210> 5279
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5279
cuguauagaa gguuuuugua g 21
<210> 5280
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5280
cuguauuugu ucagugacua u 21
<210> 5281
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5281
cugucacccc cgaaucauga c 21
<210> 5282
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5282
cugucacugu cucuccggac a 21
<210> 5283
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5283
cugucaggac accagccugg u 21
<210> 5284
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5284
cuguccccgg cauucauuga c 21
<210> 5285
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5285
cuguccgaag ccuguucugc c 21
<210> 5286
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5286
cugucgugug uguugggaug g 21
<210> 5287
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5287
cugucuagca aggcuugcau a 21
<210> 5288
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5288
cugucucucc ggacaucagu g 21
<210> 5289
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5289
cugucuuuga auaaaacaag g 21
<210> 5290
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5290
cuguguacau uuggcauuug u 21
<210> 5291
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5291
cuguguaggg gguuauugcc u 21
<210> 5292
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5292
cugugucugg ccaaauucau u 21
<210> 5293
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5293
cugugugcaa cgcuuuuugg g 21
<210> 5294
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5294
cuguugcacu gauguccgga g 21
<210> 5295
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5295
cuguugugug uugaaagcca c 21
<210> 5296
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5296
cuguuucucu uauccuucac g 21
<210> 5297
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5297
cuguuuucug ucgugugugu u 21
<210> 5298
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5298
cuuaaaaaau gaauuuggcc a 21
<210> 5299
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5299
cuuaagccag gaaagggauu c 21
<210> 5300
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5300
cuuaaggaag guacaaaccc a 21
<210> 5301
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5301
cuuaauaaau auuaagggug a 21
<210> 5302
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5302
cuuacuaugu ugcccaggcu g 21
<210> 5303
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5303
cuuagagauu gguggaugag g 21
<210> 5304
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5304
cuuaucacgg uucccugcac u 21
<210> 5305
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5305
cuuauccuuc acgaggaaag g 21
<210> 5306
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5306
cuucaaagcc gugaucguga a 21
<210> 5307
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5307
cuucacgagg aaaggaagaa a 21
<210> 5308
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5308
cuucacgcgg gagucugacg g 21
<210> 5309
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5309
cuucagguuc uuucugaaau c 21
<210> 5310
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5310
cuuccacuuc uaugcaaaug c 21
<210> 5311
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5311
cuuccauguu ugaggauugu g 21
<210> 5312
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5312
cuuccauucc cguggucucc u 21
<210> 5313
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5313
cuucccagag gcagagccug a 21
<210> 5314
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5314
cuuccccaau cuugucguug a 21
<210> 5315
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5315
cuuccugaga ccucgccggc c 21
<210> 5316
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5316
cuuccuggag agaaauggag g 21
<210> 5317
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5317
cuuccuuaag ccaggaaagg g 21
<210> 5318
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5318
cuuccuuucc ucgugaagga u 21
<210> 5319
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5319
cuucggacag ugcccaugca a 21
<210> 5320
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5320
cuucuauaca gugguuuaaa a 21
<210> 5321
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5321
cuucuaugca aaugccucca a 21
<210> 5322
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5322
cuucuaugca agccuugcua g 21
<210> 5323
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5323
cuucucuggg ccugacaucc c 21
<210> 5324
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5324
cuucucuguc uuugaauaaa a 21
<210> 5325
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5325
cuucugggag auggguguca c 21
<210> 5326
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5326
cuugcacuuu cucaguucag a 21
<210> 5327
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5327
cuugcauaga agagguaaac a 21
<210> 5328
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5328
cuugcuagac agccagguua g 21
<210> 5329
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5329
cuugcuucuc ugggccugac a 21
<210> 5330
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5330
cuuggaggca uuugcauaga a 21
<210> 5331
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5331
cuuggccgug aggacacgug g 21
<210> 5332
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5332
cuuggguugg gauuuugguu u 21
<210> 5333
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5333
cuugucguug auggguaugu g 21
<210> 5334
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5334
cuugugacau cuucacgcgg g 21
<210> 5335
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5335
cuuguuuuau ucaaagacag a 21
<210> 5336
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5336
cuuuaugucc gcccaccuag u 21
<210> 5337
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5337
cuuucaucuu ccauguuuga g 21
<210> 5338
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5338
cuuucccugg ccugggaucc c 21
<210> 5339
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5339
cuuuccucgu gaaggauaag a 21
<210> 5340
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5340
cuuuccuggc uuaaggaagg u 21
<210> 5341
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5341
cuuucgaggu ggguuuguac c 21
<210> 5342
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5342
cuuucucagu ucagaguugu a 21
<210> 5343
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5343
cuuucugaaa ucgccguguu a 21
<210> 5344
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5344
cuuucugguu ucggagcacg u 21
<210> 5345
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5345
cuuugaaguc ccggucaacc u 21
<210> 5346
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5346
cuuugaauaa aacaaggccg g 21
<210> 5347
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5347
cuuugcccug ucacccccga a 21
<210> 5348
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5348
cuuugggagg cugagcugga u 21
<210> 5349
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5349
cuuuggucuu cucugucuuu g 21
<210> 5350
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5350
cuuuguacau aaagaagagg c 21
<210> 5351
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5351
cuuuguugcu caggccuggu c 21
<210> 5352
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5352
cuuuuuggga gaaugauguc c 21
<210> 5353
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5353
cuuuuugguu uuuguagaga u 21
<210> 5354
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5354
gaaacaggcc cggggggacc a 21
<210> 5355
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5355
gaaaccaaaa ucccaaccca a 21
<210> 5356
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5356
gaaaccagaa aggcuuauca c 21
<210> 5357
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5357
gaaacucaaa acuuccugga g 21
<210> 5358
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5358
gaaagaaccu gaagucccgu c 21
<210> 5359
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5359
gaaagacacu ggguggguca u 21
<210> 5360
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5360
gaaagcagug gcauaaucau a 21
<210> 5361
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5361
gaaagccacu ugcuucucug g 21
<210> 5362
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5362
gaaagcccgu gucaaugaau g 21
<210> 5363
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5363
gaaaggaaga aaccaaaauc c 21
<210> 5364
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5364
gaaaggcuua ucacgguucc c 21
<210> 5365
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5365
gaaagggauu cauggcgucg g 21
<210> 5366
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5366
gaaaggggag gggaugucag g 21
<210> 5367
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5367
gaaagugcaa ggagaccacg g 21
<210> 5368
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5368
gaaaucgccg uguuacuguu g 21
<210> 5369
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5369
gaaaugaucu ggcugaaucc g 21
<210> 5370
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5370
gaaaugccuc uucuuuaugu a 21
<210> 5371
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5371
gaaauggagg ugucauccug g 21
<210> 5372
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5372
gaacaaauac agcaaccagg g 21
<210> 5373
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5373
gaacaggcuu cggacagugc c 21
<210> 5374
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5374
gaacaucugc cuggaguccc g 21
<210> 5375
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5375
gaacccuucc ugagaccucg c 21
<210> 5376
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5376
gaaccgugau aagccuuucu g 21
<210> 5377
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5377
gaaccugaag ucccgucaaa c 21
<210> 5378
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5378
gaacucaagu gauccagcuc a 21
<210> 5379
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5379
gaacugagaa agugcaagga g 21
<210> 5380
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5380
gaacugccau ugucgucuuu a 21
<210> 5381
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5381
gaacuggacu gugugcaacg c 21
<210> 5382
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5382
gaagaaacca aaaucccaac c 21
<210> 5383
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5383
gaagaccaaa gcauugccug c 21
<210> 5384
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5384
gaagacccua uuucagaaau a 21
<210> 5385
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5385
gaagaggcau uucagaggca a 21
<210> 5386
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5386
gaagagguaa acacguugac u 21
<210> 5387
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5387
gaagaugaaa ggggagggga u 21
<210> 5388
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5388
gaagauguca caagggauug g 21
<210> 5389
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5389
gaagcaagug gcuuucaaca c 21
<210> 5390
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5390
gaagcacuag gugggcggac a 21
<210> 5391
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5391
gaagccacuc auacauacaa c 21
<210> 5392
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5392
gaagccuguu cugccuccca g 21
<210> 5393
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5393
gaaggauaag agaaacaggc c 21
<210> 5394
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5394
gaaggguucu gggcagggac g 21
<210> 5395
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5395
gaagguacaa acccaccucg a 21
<210> 5396
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5396
gaagguuuuu guagccugaa u 21
<210> 5397
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5397
gaagucccgg ucaaccugcc c 21
<210> 5398
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5398
gaagucccgu caaacgaucc a 21
<210> 5399
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5399
gaagugaaug gcuuggaggc a 21
<210> 5400
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5400
gaaguggaag cacuaggugg g 21
<210> 5401
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5401
gaaguggcau cauuugguga a 21
<210> 5402
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5402
gaagugggua ggggucggga g 21
<210> 5403
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5403
gaaguuuuga guuucucucc a 21
<210> 5404
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5404
gaauaaaaca aggccggcga g 21
<210> 5405
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5405
gaauagucac ugaacaaaua c 21
<210> 5406
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5406
gaauaucgag aacugccauu g 21
<210> 5407
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5407
gaaucaugac ccacccagug u 21
<210> 5408
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5408
gaaucccuuu ccuggcuuaa g 21
<210> 5409
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5409
gaauccgugg uggcaccgag a 21
<210> 5410
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5410
gaaugaguuu ggucucggug c 21
<210> 5411
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5411
gaaugauguc cccguuguau g 21
<210> 5412
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5412
gaaugccggg gacagagagg g 21
<210> 5413
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5413
gaauggaagu ggguaggggu c 21
<210> 5414
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5414
gaauggcuug gaggcauuug c 21
<210> 5415
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5415
gaauuuggcc agacacaggu g 21
<210> 5416
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5416
gacaagauug gggaagugaa u 21
<210> 5417
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5417
gacaauggca guucucgaua u 21
<210> 5418
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5418
gacaauugcc aaucccuugu g 21
<210> 5419
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5419
gacacaaucc ucaaacaugg a 21
<210> 5420
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5420
gacacaggug ccucacgccu g 21
<210> 5421
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5421
gacacagugu uuugucccug g 21
<210> 5422
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5422
gacaccagcc uggugcccau c 21
<210> 5423
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5423
gacacccauc ucccagaagc c 21
<210> 5424
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5424
gacacccggu uaccuuggcc g 21
<210> 5425
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5425
gacaccucca uuucucucca g 21
<210> 5426
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5426
gacacgggcu uucccuggcc u 21
<210> 5427
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5427
gacacguggc cugcacccag g 21
<210> 5428
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5428
gacacugggu gggucaugau u 21
<210> 5429
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5429
gacagagaag accaaagcau u 21
<210> 5430
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5430
gacagagagg ggcagguuga c 21
<210> 5431
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5431
gacagauggu cagucuggag g 21
<210> 5432
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5432
gacagccaca ccugggugca g 21
<210> 5433
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5433
gacagccagg uuagccuuug c 21
<210> 5434
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5434
gacagccuca aaugccugag c 21
<210> 5435
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5435
gacagccucc gucagacucc c 21
<210> 5436
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5436
gacagggcaa aggcuaaccu g 21
<210> 5437
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5437
gacagugaca gccuccguca g 21
<210> 5438
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5438
gacagugccc augcaauggc u 21
<210> 5439
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5439
gacauaaaga cgacaauggc a 21
<210> 5440
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5440
gacaucagug caacaguaac a 21
<210> 5441
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5441
gacaucauuc ucccaaaaag c 21
<210> 5442
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5442
gacauccccu ccccuuucau c 21
<210> 5443
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5443
gacaucuuca cgcgggaguc u 21
<210> 5444
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5444
gacauucagg cuacaaaaac c 21
<210> 5445
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5445
gaccaaacuc auucaccaaa u 21
<210> 5446
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5446
gaccaaagca uugccugcca g 21
<210> 5447
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5447
gaccacggga auggaagugg g 21
<210> 5448
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5448
gaccaggaug acaccuccau u 21
<210> 5449
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5449
gaccaggccu gagcaacaaa g 21
<210> 5450
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5450
gaccagugac ucaggcucug c 21
<210> 5451
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5451
gacccaccca gugucuuucg a 21
<210> 5452
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5452
gaccccaucu cuuaaaaaau g 21
<210> 5453
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5453
gacccccugg cccugccuca u 21
<210> 5454
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5454
gaccccuacc cacuuccauu c 21
<210> 5455
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5455
gaccgggacu ucaaagccgu g 21
<210> 5456
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5456
gaccucgccg gccuuguuuu a 21
<210> 5457
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5457
gacgacaaug gcaguucucg a 21
<210> 5458
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5458
gacgcauuua cgugcuccga a 21
<210> 5459
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5459
gacgccauga aucccuuucc u 21
<210> 5460
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5460
gacggaggcu gucacugucu c 21
<210> 5461
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5461
gacgggacuc caggcagaug u 21
<210> 5462
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5462
gacgggacuu cagguucuuu c 21
<210> 5463
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5463
gacguggcgu gaacaucugc c 21
<210> 5464
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5464
gacuauucuc ggggcccugu g 21
<210> 5465
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5465
gacucaggcu cugccucugg g 21
<210> 5466
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5466
gacuccaggc agauguucac g 21
<210> 5467
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5467
gacucccgcg ugaagauguc a 21
<210> 5468
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5468
gacuccugag uuuagggguu u 21
<210> 5469
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5469
gacugugugc aacgcuuuuu g 21
<210> 5470
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5470
gacuucaaag ccgugaucgu g 21
<210> 5471
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5471
gacuucaggu ucuuucugaa a 21
<210> 5472
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5472
gagaaacagg cccgggggga c 21
<210> 5473
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5473
gagaaacuca aaacuuccug g 21
<210> 5474
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5474
gagaaagugc aaggagacca c 21
<210> 5475
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5475
gagaaaugga ggugucaucc u 21
<210> 5476
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5476
gagaacugcc auugucgucu u 21
<210> 5477
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5477
gagaagacca aagcauugcc u 21
<210> 5478
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5478
gagaagcaag uggcuuucaa c 21
<210> 5479
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5479
gagaauaguc acugaacaaa u 21
<210> 5480
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5480
gagaaugaug uccccguugu a 21
<210> 5481
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5481
gagacacccg guuaccuugg c 21
<210> 5482
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5482
gagacagaug gucagucugg a 21
<210> 5483
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5483
gagacaguga cagccuccgu c 21
<210> 5484
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5484
gagaccaaac ucauucacca a 21
<210> 5485
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5485
gagaccacgg gaauggaagu g 21
<210> 5486
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5486
gagaccaggc cugagcaaca a 21
<210> 5487
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5487
gagaccucgc cggccuuguu u 21
<210> 5488
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5488
gagagaaacu caaaacuucc u 21
<210> 5489
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5489
gagagaaaug gaggugucau c 21
<210> 5490
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5490
gagagacagu gacagccucc g 21
<210> 5491
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5491
gagaggggca gguugaccgg g 21
<210> 5492
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5492
gagaucccau cucuacaaaa a 21
<210> 5493
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5493
gagaugggau cucgcuuugu u 21
<210> 5494
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5494
gagaugggug ucacuuuuua a 21
<210> 5495
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5495
gagauuggug gaugaggcag g 21
<210> 5496
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5496
gagcaacaaa gcgagauccc a 21
<210> 5497
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5497
gagcacguaa augcgucccu g 21
<210> 5498
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5498
gagccacugc gcccggccuc a 21
<210> 5499
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5499
gagccugagu cacuggucac c 21
<210> 5500
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5500
gagcuaugau uaugccacug c 21
<210> 5501
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5501
gagcucaggc auuugaggcu g 21
<210> 5502
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5502
gaggaaagga agaaaccaaa a 21
<210> 5503
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5503
gaggacacgu ggccugcacc c 21
<210> 5504
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5504
gaggaugacg uggcgugaac a 21
<210> 5505
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5505
gaggaugggc accaggcugg u 21
<210> 5506
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5506
gaggaugguu ugagcucagg c 21
<210> 5507
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5507
gaggauugug ucacggugga g 21
<210> 5508
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5508
gaggcaauaa cccccuacac a 21
<210> 5509
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5509
gaggcaccug ugucuggcca a 21
<210> 5510
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5510
gaggcagaac aggcuucgga c 21
<210> 5511
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5511
gaggcagagc cugagucacu g 21
<210> 5512
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5512
gaggcagggc cagggggucc c 21
<210> 5513
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5513
gaggcauuuc agaggcaaua a 21
<210> 5514
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5514
gaggcauuug cauagaagug g 21
<210> 5515
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5515
gaggccaugg gcugcugaug c 21
<210> 5516
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5516
gaggcugagc uggaucacuu g 21
<210> 5517
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5517
gaggcuguca cugucucucc g 21
<210> 5518
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5518
gaggggaugu caggcccaga g 21
<210> 5519
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5519
gaggggcagg uugaccggga c 21
<210> 5520
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5520
gagguaaaca cguugacucc u 21
<210> 5521
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5521
gaggucucag gaaggguucu g 21
<210> 5522
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5522
gagguggguu uguaccuucc u 21
<210> 5523
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5523
gaggugucau ccuggucccc c 21
<210> 5524
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5524
gagucaacgu guuuaccucu u 21
<210> 5525
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5525
gagucacugg ucacccuuaa u 21
<210> 5526
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5526
gagucccguc ccugcccaga a 21
<210> 5527
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5527
gagucugacg gaggcuguca c 21
<210> 5528
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5528
gaguggcuuc ugggagaugg g 21
<210> 5529
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5529
gaguucagga guuggagacc a 21
<210> 5530
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5530
gaguuggaga ccaggccuga g 21
<210> 5531
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5531
gaguuguaca cuguguacau u 21
<210> 5532
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5532
gaguuuaggg guuuggcuua g 21
<210> 5533
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5533
gaguuucucu ccaccgugac a 21
<210> 5534
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5534
gaguuugguc ucggugccac c 21
<210> 5535
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5535
gauaagagaa acaggcccgg g 21
<210> 5536
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5536
gauaagccuu ucugguuucg g 21
<210> 5537
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5537
gauagugggg auuuuuuguu a 21
<210> 5538
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5538
gauauucacg aucacggcuu u 21
<210> 5539
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5539
gaucacaggc acgugccacc g 21
<210> 5540
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5540
gaucacagua agacauucag g 21
<210> 5541
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5541
gaucacggcu uugaaguccc g 21
<210> 5542
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5542
gaucauuucc gacgccauga a 21
<210> 5543
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5543
gauccagacu ggaggauuua u 21
<210> 5544
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5544
gauccagcuc agccucccaa a 21
<210> 5545
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5545
gaucccaggc cagggaaagc c 21
<210> 5546
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5546
gaucccaucc caacacacac g 21
<210> 5547
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5547
gaucccaucu cuacaaaaac c 21
<210> 5548
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5548
gaucgugaau aucgagaacu g 21
<210> 5549
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5549
gaucguuuga cgggacuuca g 21
<210> 5550
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5550
gaucucgcuu uguugcucag g 21
<210> 5551
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5551
gaucuggcug aauccguggu g 21
<210> 5552
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5552
gaugaaaggg gaggggaugu c 21
<210> 5553
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5553
gaugaagacc cuauuucaga a 21
<210> 5554
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5554
gaugacaccu ccauuucucu c 21
<210> 5555
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5555
gaugacgugg cgugaacauc u 21
<210> 5556
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5556
gaugaggcag ggccaggggg u 21
<210> 5557
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5557
gaugccacuu cccagaggca g 21
<210> 5558
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5558
gauggcacca acgggacccc c 21
<210> 5559
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5559
gaugggaucc caggccaggg a 21
<210> 5560
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5560
gaugggaucu cgcuuuguug c 21
<210> 5561
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5561
gaugggcacc aggcuggugu c 21
<210> 5562
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5562
gauggguaug uguuuaaaac a 21
<210> 5563
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5563
gauggguguc acuuuuuaaa c 21
<210> 5564
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5564
gauggucagu cuggaggaug a 21
<210> 5565
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5565
gaugguuuga gcucaggcau u 21
<210> 5566
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5566
gaugucacaa gggauuggca a 21
<210> 5567
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5567
gaugucaggc ccagagaagc a 21
<210> 5568
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5568
gauguccccg uuguauguau g 21
<210> 5569
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5569
gauguccgga gagacaguga c 21
<210> 5570
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5570
gauguucacg ccacgucauc c 21
<210> 5571
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5571
gauuacaggc gugaggcacc u 21
<210> 5572
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5572
gauuaugcca cugcuuucca g 21
<210> 5573
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5573
gauuauuugc acgaacugga c 21
<210> 5574
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5574
gauucagcca gaucauuucc g 21
<210> 5575
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5575
gauucauggc gucggaaaug a 21
<210> 5576
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5576
gauucggggg ugacagggca a 21
<210> 5577
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5577
gauuggcaau uguccccagg g 21
<210> 5578
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5578
gauuggggaa gugaauggcu u 21
<210> 5579
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5579
gauuggugga ugaggcaggg c 21
<210> 5580
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5580
gauuguguca cgguggagag a 21
<210> 5581
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5581
gauuucagaa agaaccugaa g 21
<210> 5582
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5582
gauuuugguu ucuuccuuuc c 21
<210> 5583
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5583
gcaaacauaa caaaaaaucc c 21
<210> 5584
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5584
gcaaacccug guugcuguau u 21
<210> 5585
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5585
gcaaaggcua accuggcugu c 21
<210> 5586
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5586
gcaaaugccu ccaagccauu c 21
<210> 5587
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5587
gcaacagaug aagacccuau u 21
<210> 5588
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5588
gcaacaguaa cacggcgauu u 21
<210> 5589
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5589
gcaaccaggg uuugcaaaaa u 21
<210> 5590
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5590
gcaacgcuuu uugggagaau g 21
<210> 5591
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5591
gcaagccuug cuagacagcc a 21
<210> 5592
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5592
gcaaggagac cacgggaaug g 21
<210> 5593
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5593
gcaaggcuug cauagaagag g 21
<210> 5594
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5594
gcaaguggcu uucaacacac a 21
<210> 5595
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5595
gcaauaaccc ccuacacagg g 21
<210> 5596
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5596
gcaaugcuuu ggucuucucu g 21
<210> 5597
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5597
gcaauggcuu ggguugggau u 21
<210> 5598
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5598
gcaauugucc ccagggacaa a 21
<210> 5599
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5599
gcacacaguc caguucgugc a 21
<210> 5600
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5600
gcaccaacgg gacccccugg c 21
<210> 5601
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5601
gcaccaggcu gguguccuga c 21
<210> 5602
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5602
gcacccaggu guggcuguca g 21
<210> 5603
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5603
gcaccgagac caaacucauu c 21
<210> 5604
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5604
gcaccugugu cuggccaaau u 21
<210> 5605
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5605
gcacgaacug gacugugugc a 21
<210> 5606
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5606
gcacggugag gccgggcgca g 21
<210> 5607
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5607
gcacguaaau gcgucccugu a 21
<210> 5608
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5608
gcacgugcca ccguacccag c 21
<210> 5609
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5609
gcacuaggug ggcggacaua a 21
<210> 5610
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5610
gcacugaugu ccggagagac a 21
<210> 5611
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5611
gcacuguccg aagccuguuc u 21
<210> 5612
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5612
gcacuguuuu cugucgugug u 21
<210> 5613
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5613
gcacuuaaua aauauuaagg g 21
<210> 5614
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5614
gcacuuucuc aguucagagu u 21
<210> 5615
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5615
gcacuuuggg aggcugagcu g 21
<210> 5616
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5616
gcacuuugua uauugguuga a 21
<210> 5617
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5617
gcagaacagg cuucggacag u 21
<210> 5618
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5618
gcagagccug agucacuggu c 21
<210> 5619
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5619
gcagauggca ccaacgggac c 21
<210> 5620
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5620
gcagauguuc acgccacguc a 21
<210> 5621
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5621
gcagcccaug gccucuggcc a 21
<210> 5622
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5622
gcaggcaaug cuuuggucuu c 21
<210> 5623
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5623
gcaggccacg uguccucacg g 21
<210> 5624
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5624
gcagggaacc gugauaagcc u 21
<210> 5625
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5625
gcagggacgg gacuccaggc a 21
<210> 5626
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5626
gcagggccag ggggucccgu u 21
<210> 5627
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5627
gcagguugac cgggacuuca a 21
<210> 5628
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5628
gcaguggcau aaucauagcu c 21
<210> 5629
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5629
gcaguucucg auauucacga u 21
<210> 5630
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5630
gcauaaucau agcucacgac a 21
<210> 5631
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5631
gcauagaaga gguaaacacg u 21
<210> 5632
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5632
gcauagaagu ggaagcacua g 21
<210> 5633
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5633
gcaucagcag cccauggccu c 21
<210> 5634
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5634
gcaucauuug gugaaugagu u 21
<210> 5635
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5635
gcauggcgag gcugaggugg g 21
<210> 5636
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5636
gcaugggcac uguccgaagc c 21
<210> 5637
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5637
gcauggugca ucagcagccc a 21
<210> 5638
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5638
gcauguuuua aacacauacc c 21
<210> 5639
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5639
gcauucauug acacgggcuu u 21
<210> 5640
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5640
gcauugccug ccagagcuuu g 21
<210> 5641
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5641
gcauuuacgu gcuccgaaac c 21
<210> 5642
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5642
gcauuucaga ggcaauaacc c 21
<210> 5643
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5643
gcauuugagg cugucgugag c 21
<210> 5644
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5644
gcauuugcau agaaguggaa g 21
<210> 5645
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5645
gccaaacccc uaaacucagg a 21
<210> 5646
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5646
gccaaaugua cacaguguac a 21
<210> 5647
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5647
gccaaauuca uuuuuuaaga g 21
<210> 5648
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5648
gccaagguaa ccgggugucu c 21
<210> 5649
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5649
gccaaucccu ugugacaucu u 21
<210> 5650
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5650
gccacaccug ggugcaggcc a 21
<210> 5651
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5651
gccaccacgg auucagccag a 21
<210> 5652
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5652
gccaccguac ccagcugauu u 21
<210> 5653
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5653
gccacgucau ccuccagacu g 21
<210> 5654
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5654
gccacguguc cucacggcca a 21
<210> 5655
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5655
gccacucaua cauacaacgg g 21
<210> 5656
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5656
gccacugcgc ccggccucac c 21
<210> 5657
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5657
gccacuuccc agaggcagag c 21
<210> 5658
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5658
gccacuugcu ucucugggcc u 21
<210> 5659
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5659
gccagacaca ggugccucac g 21
<210> 5660
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5660
gccagaggcc augggcugcu g 21
<210> 5661
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5661
gccagaucau uuccgacgcc a 21
<210> 5662
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5662
gccaggaaag ggauucaugg c 21
<210> 5663
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5663
gccagggaaa gcccguguca a 21
<210> 5664
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5664
gccagggggu cccguuggug c 21
<210> 5665
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5665
gccagguuag ccuuugcccu g 21
<210> 5666
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5666
gccaucugcu guuguguguu g 21
<210> 5667
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5667
gccaugaauc ccuuuccugg c 21
<210> 5668
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5668
gccaugccug gccagaggcc a 21
<210> 5669
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5669
gccaugggcu gcugaugcac c 21
<210> 5670
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5670
gccauucacu uccccaaucu u 21
<210> 5671
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5671
gccauugcau gggcacuguc c 21
<210> 5672
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5672
gccauugucg ucuuuauguc c 21
<210> 5673
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5673
gcccaccuag ugcuuccacu u 21
<210> 5674
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5674
gcccagaacc cuuccugaga c 21
<210> 5675
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5675
gcccagagaa gcaaguggcu u 21
<210> 5676
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5676
gcccaggcug gaaagcagug g 21
<210> 5677
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5677
gcccauccuc ccgaccccua c 21
<210> 5678
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5678
gcccaugcaa uggcuugggu u 21
<210> 5679
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5679
gcccauggcc ucuggccagg c 21
<210> 5680
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5680
gccccgagaa uagucacuga a 21
<210> 5681
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5681
gccccucucu guccccggca u 21
<210> 5682
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5682
gcccggccuc accgugcaug u 21
<210> 5683
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5683
gcccgggggg accaggauga c 21
<210> 5684
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5684
gcccguguca augaaugccg g 21
<210> 5685
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5685
gcccugccuc auccaccaau c 21
<210> 5686
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5686
gcccugucac ccccgaauca u 21
<210> 5687
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5687
gcccugugua ggggguuauu g 21
<210> 5688
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5688
gccggccuug uuuuauucaa a 21
<210> 5689
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5689
gccggcgagg ucucaggaag g 21
<210> 5690
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5690
gccggggaca gagaggggca g 21
<210> 5691
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5691
gccgugagga cacguggccu g 21
<210> 5692
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5692
gccgugaucg ugaauaucga g 21
<210> 5693
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5693
gccguguuac uguugcacug a 21
<210> 5694
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5694
gccucaaaug ccugagcuca a 21
<210> 5695
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5695
gccucaccgu gcauguuuua a 21
<210> 5696
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5696
gccucaucca ccaaucucua a 21
<210> 5697
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5697
gccuccaagc cauucacuuc c 21
<210> 5698
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5698
gccuccguca gacucccgcg u 21
<210> 5699
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5699
gccucgccau gccuggccag a 21
<210> 5700
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5700
gccucugaaa ugccucuucu u 21
<210> 5701
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5701
gccucuggcc aggcauggcg a 21
<210> 5702
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5702
gccucuggga aguggcauca u 21
<210> 5703
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5703
gccugacauc cccuccccuu u 21
<210> 5704
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5704
gccugagaca cccgguuacc u 21
<210> 5705
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5705
gccugagcaa caaagcgaga u 21
<210> 5706
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5706
gccugagcuc aaaccauccu c 21
<210> 5707
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5707
gccugaguca cuggucaccc u 21
<210> 5708
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5708
gccugcaccc agguguggcu g 21
<210> 5709
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5709
gccugccaga gcuuuguuuu a 21
<210> 5710
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5710
gccuggaguc ccgucccugc c 21
<210> 5711
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5711
gccuggccag aggccauggg c 21
<210> 5712
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5712
gccugggauc ccaucccaac a 21
<210> 5713
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5713
gccuggugcc cauccucccg a 21
<210> 5714
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5714
gccuguucug ccucccagau g 21
<210> 5715
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5715
gccuguuucu cuuauccuuc a 21
<210> 5716
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5716
gccuugcuag acagccaggu u 21
<210> 5717
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5717
gccuuguuuu auucaaagac a 21
<210> 5718
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5718
gccuuucugg uuucggagca c 21
<210> 5719
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5719
gccuuugccc ugucaccccc g 21
<210> 5720
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5720
gcgagauccc aucucuacaa a 21
<210> 5721
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5721
gcgaggucuc aggaaggguu c 21
<210> 5722
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5722
gcgauuucag aaagaaccug a 21
<210> 5723
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5723
gcgcccggcc ucaccgugca u 21
<210> 5724
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5724
gcggacauaa agacgacaau g 21
<210> 5725
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5725
gcgggagucu gacggaggcu g 21
<210> 5726
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5726
gcgucccugu acagauagug g 21
<210> 5727
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5727
gcgucggaaa ugaucuggcu g 21
<210> 5728
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5728
gcgugaacau cugccuggag u 21
<210> 5729
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5729
gcgugaagau gucacaaggg a 21
<210> 5730
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5730
gcgugaggca ccugugucug g 21
<210> 5731
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5731
gcguugcaca caguccaguu c 21
<210> 5732
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5732
gcuaaccugg cugucuagca a 21
<210> 5733
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5733
gcuacaaaaa ccuucuauac a 21
<210> 5734
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5734
gcuagacagc cagguuagcc u 21
<210> 5735
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5735
gcuaugauua ugccacugcu u 21
<210> 5736
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5736
gcucacgaca gccucaaaug c 21
<210> 5737
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5737
gcucaggcau uugaggcugu c 21
<210> 5738
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5738
gcucaggccu ggucuccaac u 21
<210> 5739
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5739
gcuccgaaac cagaaaggcu u 21
<210> 5740
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5740
gcucgaucau ggcucacugc a 21
<210> 5741
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5741
gcucugccuc ugggaagugg c 21
<210> 5742
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5742
gcucuggcag gcaaugcuuu g 21
<210> 5743
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5743
gcugaauccg ugguggcacc g 21
<210> 5744
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5744
gcugagcugg aucacuugag u 21
<210> 5745
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5745
gcugcugaug caccaugcau g 21
<210> 5746
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5746
gcuggaaagc aguggcauaa u 21
<210> 5747
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5747
gcuggaucac uugaguucag g 21
<210> 5748
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5748
gcuggguacg guggcacgug c 21
<210> 5749
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5749
gcuggugucc ugacagccac a 21
<210> 5750
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5750
gcuguauuug uucagugacu a 21
<210> 5751
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5751
gcugucacug ucucuccgga c 21
<210> 5752
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5752
gcugucagga caccagccug g 21
<210> 5753
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5753
gcugucuagc aaggcuugca u 21
<210> 5754
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5754
gcuguugugu guugaaagcc a 21
<210> 5755
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5755
gcuuaaggaa gguacaaacc c 21
<210> 5756
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5756
gcuuagagau ugguggauga g 21
<210> 5757
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5757
gcuuaucacg guucccugca c 21
<210> 5758
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5758
gcuuccacuu cuaugcaaau g 21
<210> 5759
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5759
gcuucggaca gugcccaugc a 21
<210> 5760
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5760
gcuucucugg gccugacauc c 21
<210> 5761
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5761
gcuucuggga gauggguguc a 21
<210> 5762
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5762
gcuugcauag aagagguaaa c 21
<210> 5763
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5763
gcuuggaggc auuugcauag a 21
<210> 5764
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5764
gcuuggguug ggauuuuggu u 21
<210> 5765
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5765
gcuuucaaca cacaacagca g 21
<210> 5766
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5766
gcuuuccagc cugggcaaca u 21
<210> 5767
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5767
gcuuucccug gccugggauc c 21
<210> 5768
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5768
gcuuugaagu cccggucaac c 21
<210> 5769
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5769
gcuuuggucu ucucugucuu u 21
<210> 5770
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5770
gcuuuguugc ucaggccugg u 21
<210> 5771
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5771
gcuuuuuggg agaaugaugu c 21
<210> 5772
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5772
ggaaagcagu ggcauaauca u 21
<210> 5773
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5773
ggaaagcccg ugucaaugaa u 21
<210> 5774
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5774
ggaaaggaag aaaccaaaau c 21
<210> 5775
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5775
ggaaagggau ucauggcguc g 21
<210> 5776
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5776
ggaaaugauc uggcugaauc c 21
<210> 5777
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5777
ggaaccguga uaagccuuuc u 21
<210> 5778
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5778
ggaagaaacc aaaaucccaa c 21
<210> 5779
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5779
ggaagaugaa aggggagggg a 21
<210> 5780
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5780
ggaagcacua ggugggcgga c 21
<210> 5781
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5781
ggaaggguuc ugggcaggga c 21
<210> 5782
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5782
ggaagguaca aacccaccuc g 21
<210> 5783
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5783
ggaagugaau ggcuuggagg c 21
<210> 5784
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5784
ggaaguggca ucauuuggug a 21
<210> 5785
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5785
ggaagugggu aggggucggg a 21
<210> 5786
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5786
ggaaguuuug aguuucucuc c 21
<210> 5787
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5787
ggaauggaag uggguagggg u 21
<210> 5788
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5788
ggacaauugc caaucccuug u 21
<210> 5789
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5789
ggacacagug uuuugucccu g 21
<210> 5790
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5790
ggacacgugg ccugcaccca g 21
<210> 5791
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5791
ggacagagag gggcagguug a 21
<210> 5792
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5792
ggacagugcc caugcaaugg c 21
<210> 5793
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5793
ggacauaaag acgacaaugg c 21
<210> 5794
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5794
ggacaucagu gcaacaguaa c 21
<210> 5795
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5795
ggacaucauu cucccaaaaa g 21
<210> 5796
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5796
ggaccaggau gacaccucca u 21
<210> 5797
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5797
ggacccccug gcccugccuc a 21
<210> 5798
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5798
ggacgcauuu acgugcuccg a 21
<210> 5799
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5799
ggacgggacu ccaggcagau g 21
<210> 5800
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5800
ggacuccagg cagauguuca c 21
<210> 5801
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5801
ggacugugug caacgcuuuu u 21
<210> 5802
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5802
ggacuucaaa gccgugaucg u 21
<210> 5803
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5803
ggacuucagg uucuuucuga a 21
<210> 5804
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5804
ggagaaugau guccccguug u 21
<210> 5805
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5805
ggagaccacg ggaauggaag u 21
<210> 5806
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5806
ggagaccagg ccugagcaac a 21
<210> 5807
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5807
ggagagaaac ucaaaacuuc c 21
<210> 5808
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5808
ggagagaaau ggagguguca u 21
<210> 5809
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5809
ggagagacag ugacagccuc c 21
<210> 5810
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5810
ggagaugggu gucacuuuuu a 21
<210> 5811
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5811
ggagcacgua aaugcguccc u 21
<210> 5812
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5812
ggaggaugac guggcgugaa c 21
<210> 5813
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5813
ggaggauggg caccaggcug g 21
<210> 5814
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5814
ggaggauggu uugagcucag g 21
<210> 5815
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5815
ggaggcagaa caggcuucgg a 21
<210> 5816
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5816
ggaggcauuu gcauagaagu g 21
<210> 5817
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5817
ggaggcugag cuggaucacu u 21
<210> 5818
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5818
ggaggcuguc acugucucuc c 21
<210> 5819
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5819
ggaggggaug ucaggcccag a 21
<210> 5820
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5820
ggagguguca uccugguccc c 21
<210> 5821
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5821
ggagguugca gugagccaug a 21
<210> 5822
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5822
ggagucaacg uguuuaccuc u 21
<210> 5823
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5823
ggagucccgu cccugcccag a 21
<210> 5824
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5824
ggagucugac ggaggcuguc a 21
<210> 5825
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5825
ggaguuggag accaggccug a 21
<210> 5826
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5826
ggauaagaga aacaggcccg g 21
<210> 5827
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5827
ggaucacagg cacgugccac c 21
<210> 5828
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5828
ggaucccagg ccagggaaag c 21
<210> 5829
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5829
ggaucccauc ccaacacaca c 21
<210> 5830
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5830
ggaucguuug acgggacuuc a 21
<210> 5831
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5831
ggaucucgcu uuguugcuca g 21
<210> 5832
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5832
ggaugacacc uccauuucuc u 21
<210> 5833
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5833
ggaugacgug gcgugaacau c 21
<210> 5834
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5834
ggaugaggca gggccagggg g 21
<210> 5835
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5835
ggaugggauc ccaggccagg g 21
<210> 5836
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5836
ggaugggcac caggcuggug u 21
<210> 5837
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5837
ggaugguuug agcucaggca u 21
<210> 5838
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5838
ggaugucagg cccagagaag c 21
<210> 5839
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5839
ggauuacagg cgugaggcac c 21
<210> 5840
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5840
ggauucagcc agaucauuuc c 21
<210> 5841
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5841
ggauucaugg cgucggaaau g 21
<210> 5842
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5842
ggauuggcaa uuguccccag g 21
<210> 5843
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5843
ggauuguguc acgguggaga g 21
<210> 5844
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5844
ggauuuuggu uucuuccuuu c 21
<210> 5845
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5845
ggcaaaggcu aaccuggcug u 21
<210> 5846
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5846
ggcaacagau gaagacccua u 21
<210> 5847
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5847
ggcaauaacc cccuacacag g 21
<210> 5848
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5848
ggcaaugcuu uggucuucuc u 21
<210> 5849
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5849
ggcaauuguc cccagggaca a 21
<210> 5850
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5850
ggcaccaacg ggacccccug g 21
<210> 5851
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5851
ggcaccaggc ugguguccug a 21
<210> 5852
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5852
ggcaccgaga ccaaacucau u 21
<210> 5853
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5853
ggcaccugug ucuggccaaa u 21
<210> 5854
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5854
ggcacgugcc accguaccca g 21
<210> 5855
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5855
ggcacugucc gaagccuguu c 21
<210> 5856
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5856
ggcacuuaau aaauauuaag g 21
<210> 5857
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5857
ggcagaacag gcuucggaca g 21
<210> 5858
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5858
ggcagagccu gagucacugg u 21
<210> 5859
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5859
ggcagauguu cacgccacgu c 21
<210> 5860
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5860
ggcaggcaau gcuuuggucu u 21
<210> 5861
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5861
ggcagggacg ggacuccagg c 21
<210> 5862
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5862
ggcagggcca gggggucccg u 21
<210> 5863
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5863
ggcagguuga ccgggacuuc a 21
<210> 5864
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5864
ggcaguucuc gauauucacg a 21
<210> 5865
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5865
ggcaucauuu ggugaaugag u 21
<210> 5866
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5866
ggcauggcga ggcugaggug g 21
<210> 5867
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5867
ggcauucauu gacacgggcu u 21
<210> 5868
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5868
ggcauuucag aggcaauaac c 21
<210> 5869
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5869
ggcauuugag gcugucguga g 21
<210> 5870
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5870
ggcauuugca uagaagugga a 21
<210> 5871
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5871
ggcauuugug uuauuauuuu g 21
<210> 5872
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5872
ggccaaauuc auuuuuuaag a 21
<210> 5873
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5873
ggccaaggua accggguguc u 21
<210> 5874
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5874
ggccacgugu ccucacggcc a 21
<210> 5875
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5875
ggccagacac aggugccuca c 21
<210> 5876
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5876
ggccagaggc caugggcugc u 21
<210> 5877
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5877
ggccaggcau ggcgaggcug a 21
<210> 5878
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5878
ggccagggaa agcccguguc a 21
<210> 5879
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5879
ggccaggggg ucccguuggu g 21
<210> 5880
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5880
ggccaugggc ugcugaugca c 21
<210> 5881
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5881
ggcccagaga agcaaguggc u 21
<210> 5882
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5882
ggccccgaga auagucacug a 21
<210> 5883
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5883
ggcccggggg gaccaggaug a 21
<210> 5884
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5884
ggcccugccu cauccaccaa u 21
<210> 5885
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5885
ggcccugugu aggggguuau u 21
<210> 5886
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5886
ggccggcgag gucucaggaa g 21
<210> 5887
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5887
ggccgugagg acacguggcc u 21
<210> 5888
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5888
ggccucaccg ugcauguuuu a 21
<210> 5889
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5889
ggccucuggc caggcauggc g 21
<210> 5890
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5890
ggccugacau ccccuccccu u 21
<210> 5891
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5891
ggccugagca acaaagcgag a 21
<210> 5892
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5892
ggccugcacc cagguguggc u 21
<210> 5893
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5893
ggccugggau cccaucccaa c 21
<210> 5894
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5894
ggccuggucu ccaacuccug a 21
<210> 5895
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5895
ggccuguuuc ucuuauccuu c 21
<210> 5896
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5896
ggccuuguuu uauucaaaga c 21
<210> 5897
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5897
ggcgaggcug aggugggagg a 21
<210> 5898
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5898
ggcgaggucu caggaagggu u 21
<210> 5899
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5899
ggcgauuuca gaaagaaccu g 21
<210> 5900
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5900
ggcggacaua aagacgacaa u 21
<210> 5901
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5901
ggcgucggaa augaucuggc u 21
<210> 5902
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5902
ggcgugaaca ucugccugga g 21
<210> 5903
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5903
ggcgugaggc accugugucu g 21
<210> 5904
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5904
ggcuaaccug gcugucuagc a 21
<210> 5905
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5905
ggcuacaaaa accuucuaua c 21
<210> 5906
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5906
ggcucugccu cugggaagug g 21
<210> 5907
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5907
ggcugaaucc gugguggcac c 21
<210> 5908
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5908
ggcugagcug gaucacuuga g 21
<210> 5909
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5909
ggcugcugau gcaccaugca u 21
<210> 5910
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5910
ggcuggaaag caguggcaua a 21
<210> 5911
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5911
ggcugguguc cugacagcca c 21
<210> 5912
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5912
ggcugucacu gucucuccgg a 21
<210> 5913
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5913
ggcugucagg acaccagccu g 21
<210> 5914
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5914
ggcugucuag caaggcuugc a 21
<210> 5915
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5915
ggcuuaagga agguacaaac c 21
<210> 5916
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5916
ggcuuagaga uugguggaug a 21
<210> 5917
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5917
ggcuuaucac gguucccugc a 21
<210> 5918
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5918
ggcuucggac agugcccaug c 21
<210> 5919
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5919
ggcuucuggg agaugggugu c 21
<210> 5920
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5920
ggcuugcaua gaagagguaa a 21
<210> 5921
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5921
ggcuuggagg cauuugcaua g 21
<210> 5922
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5922
ggcuuggguu gggauuuugg u 21
<210> 5923
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5923
ggcuuucaac acacaacagc a 21
<210> 5924
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5924
ggcuuucccu ggccugggau c 21
<210> 5925
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5925
ggcuuugaag ucccggucaa c 21
<210> 5926
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5926
gggaaagccc gugucaauga a 21
<210> 5927
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5927
gggaaccgug auaagccuuu c 21
<210> 5928
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5928
gggaagugaa uggcuuggag g 21
<210> 5929
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5929
gggaaguggc aucauuuggu g 21
<210> 5930
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5930
gggaauggaa guggguaggg g 21
<210> 5931
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5931
gggacaauug ccaaucccuu g 21
<210> 5932
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5932
gggacacagu guuuuguccc u 21
<210> 5933
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5933
gggacagaga ggggcagguu g 21
<210> 5934
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5934
gggacaucau ucucccaaaa a 21
<210> 5935
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5935
gggaccagga ugacaccucc a 21
<210> 5936
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5936
gggacccccu ggcccugccu c 21
<210> 5937
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5937
gggacgcauu uacgugcucc g 21
<210> 5938
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5938
gggacgggac uccaggcaga u 21
<210> 5939
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5939
gggacuccag gcagauguuc a 21
<210> 5940
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5940
gggacuucaa agccgugauc g 21
<210> 5941
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5941
gggacuucag guucuuucug a 21
<210> 5942
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5942
gggagaauga uguccccguu g 21
<210> 5943
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5943
gggagauggg ugucacuuuu u 21
<210> 5944
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5944
gggaggaugg gcaccaggcu g 21
<210> 5945
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5945
gggaggaugg uuugagcuca g 21
<210> 5946
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5946
gggaggcaga acaggcuucg g 21
<210> 5947
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5947
gggaggcuga gcuggaucac u 21
<210> 5948
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5948
gggaggggau gucaggccca g 21
<210> 5949
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5949
gggagucuga cggaggcugu c 21
<210> 5950
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5950
gggaucccag gccagggaaa g 21
<210> 5951
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5951
gggaucccau cccaacacac a 21
<210> 5952
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5952
gggaucucgc uuuguugcuc a 21
<210> 5953
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5953
gggaugggau cccaggccag g 21
<210> 5954
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5954
gggaugucag gcccagagaa g 21
<210> 5955
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5955
gggauuacag gcgugaggca c 21
<210> 5956
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5956
gggauucaug gcgucggaaa u 21
<210> 5957
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5957
gggauuggca auugucccca g 21
<210> 5958
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5958
gggauuuugg uuucuuccuu u 21
<210> 5959
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5959
gggauuuuuu guuauguuug c 21
<210> 5960
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5960
gggcaaaggc uaaccuggcu g 21
<210> 5961
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5961
gggcaacaga ugaagacccu a 21
<210> 5962
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5962
gggcaccagg cugguguccu g 21
<210> 5963
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5963
gggcacuguc cgaagccugu u 21
<210> 5964
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5964
gggcagggac gggacuccag g 21
<210> 5965
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5965
gggcagguug accgggacuu c 21
<210> 5966
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5966
gggccagggg gucccguugg u 21
<210> 5967
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5967
gggccccgag aauagucacu g 21
<210> 5968
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5968
gggcccugug uaggggguua u 21
<210> 5969
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5969
gggccugaca uccccucccc u 21
<210> 5970
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5970
gggccuguuu cucuuauccu u 21
<210> 5971
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5971
gggcggacau aaagacgaca a 21
<210> 5972
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5972
gggcugcuga ugcaccaugc a 21
<210> 5973
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5973
gggcuuuccc uggccuggga u 21
<210> 5974
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5974
ggggaaguga auggcuugga g 21
<210> 5975
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5975
ggggacaauu gccaaucccu u 21
<210> 5976
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5976
ggggacacag uguuuugucc c 21
<210> 5977
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5977
ggggacagag aggggcaggu u 21
<210> 5978
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5978
ggggacauca uucucccaaa a 21
<210> 5979
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5979
ggggaccagg augacaccuc c 21
<210> 5980
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5980
ggggagggga ugucaggccc a 21
<210> 5981
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5981
ggggauguca ggcccagaga a 21
<210> 5982
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5982
ggggauuuuu uguuauguuu g 21
<210> 5983
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5983
ggggcagguu gaccgggacu u 21
<210> 5984
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5984
ggggcccugu guaggggguu a 21
<210> 5985
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5985
gggggacaca guguuuuguc c 21
<210> 5986
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5986
gggggaccag gaugacaccu c 21
<210> 5987
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5987
ggggggacac aguguuuugu c 21
<210> 5988
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5988
ggggggacca ggaugacacc u 21
<210> 5989
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5989
gggggucccg uuggugccau c 21
<210> 5990
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5990
gggggugaca gggcaaaggc u 21
<210> 5991
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5991
ggggguuauu gccucugaaa u 21
<210> 5992
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5992
ggggucccgu uggugccauc u 21
<210> 5993
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5993
ggggucggga ggaugggcac c 21
<210> 5994
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5994
ggggugacag ggcaaaggcu a 21
<210> 5995
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5995
gggguuauug ccucugaaau g 21
<210> 5996
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5996
gggguuuggc uuagagauug g 21
<210> 5997
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5997
ggguacggug gcacgugccu g 21
<210> 5998
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5998
ggguaggggu cgggaggaug g 21
<210> 5999
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 5999
ggguaugugu uuaaaacaug c 21
<210> 6000
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6000
gggucaugau ucggggguga c 21
<210> 6001
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6001
gggucccguu ggugccaucu g 21
<210> 6002
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6002
gggucgggag gaugggcacc a 21
<210> 6003
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6003
gggugacagg gcaaaggcua a 21
<210> 6004
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6004
gggugaccag ugacucaggc u 21
<210> 6005
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6005
gggugcaggc cacguguccu c 21
<210> 6006
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6006
ggguggguca ugauucgggg g 21
<210> 6007
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6007
gggugucacu uuuuaaacca c 21
<210> 6008
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6008
gggugucuca ggcacuuaau a 21
<210> 6009
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6009
ggguuauugc cucugaaaug c 21
<210> 6010
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6010
ggguucuggg cagggacggg a 21
<210> 6011
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6011
ggguugggau uuugguuucu u 21
<210> 6012
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6012
ggguuuggcu uagagauugg u 21
<210> 6013
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6013
ggguuuguac cuuccuuaag c 21
<210> 6014
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6014
gguaaacacg uugacuccug a 21
<210> 6015
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6015
gguaaccggg ugucucaggc a 21
<210> 6016
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6016
gguacaaacc caccucgaaa g 21
<210> 6017
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6017
gguagggguc gggaggaugg g 21
<210> 6018
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6018
gguauguguu uaaaacaugc a 21
<210> 6019
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6019
ggucaaccug ccccucucug u 21
<210> 6020
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6020
ggucacccuu aauauuuauu a 21
<210> 6021
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6021
ggucagucug gaggaugacg u 21
<210> 6022
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6022
ggucaugauu cgggggugac a 21
<210> 6023
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6023
gguccccccg ggccuguuuc u 21
<210> 6024
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6024
ggucccguug gugccaucug c 21
<210> 6025
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6025
ggucgggagg augggcacca g 21
<210> 6026
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6026
ggucucagga aggguucugg g 21
<210> 6027
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6027
ggucuccuug cacuuucuca g 21
<210> 6028
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6028
ggucucggug ccaccacgga u 21
<210> 6029
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6029
ggucuucucu gucuuugaau a 21
<210> 6030
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6030
ggugaaugag uuuggucucg g 21
<210> 6031
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6031
ggugacaggg caaaggcuaa c 21
<210> 6032
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6032
ggugaccagu gacucaggcu c 21
<210> 6033
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6033
ggugcaggcc acguguccuc a 21
<210> 6034
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6034
ggugcaucag cagcccaugg c 21
<210> 6035
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6035
ggugccacca cggauucagc c 21
<210> 6036
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6036
ggugccaucu gcuguugugu g 21
<210> 6037
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6037
ggugcccauc cucccgaccc c 21
<210> 6038
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6038
gguggagaga aacucaaaac u 21
<210> 6039
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6039
gguggaugag gcagggccag g 21
<210> 6040
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6040
gguggcaccg agaccaaacu c 21
<210> 6041
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6041
ggugggagga ugguuugagc u 21
<210> 6042
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6042
ggugggcgga cauaaagacg a 21
<210> 6043
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6043
ggugggucau gauucggggg u 21
<210> 6044
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6044
gguggguuug uaccuuccuu a 21
<210> 6045
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6045
ggugucacuu uuuaaaccac u 21
<210> 6046
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6046
ggugucaucc uggucccccc g 21
<210> 6047
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6047
gguguccuga cagccacacc u 21
<210> 6048
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6048
ggugucucag gcacuuaaua a 21
<210> 6049
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6049
gguguggcug ucaggacacc a 21
<210> 6050
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6050
gguuaccuug gccgugagga c 21
<210> 6051
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6051
gguuagccuu ugcccuguca c 21
<210> 6052
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6052
gguuauugcc ucugaaaugc c 21
<210> 6053
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6053
gguucugggc agggacggga c 21
<210> 6054
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6054
gguucuuucu gaaaucgccg u 21
<210> 6055
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6055
gguugaccgg gacuucaaag c 21
<210> 6056
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6056
gguugcugua uuuguucagu g 21
<210> 6057
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6057
gguugggauu uugguuucuu c 21
<210> 6058
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6058
gguuuaaaaa gugacaccca u 21
<210> 6059
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6059
gguuucggag cacguaaaug c 21
<210> 6060
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6060
gguuucuucc uuuccucgug a 21
<210> 6061
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6061
gguuugagcu caggcauuug a 21
<210> 6062
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6062
gguuuggcuu agagauuggu g 21
<210> 6063
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6063
gguuuguacc uuccuuaagc c 21
<210> 6064
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6064
gguuuuugua gagaugggau c 21
<210> 6065
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6065
gguuuuugua gccugaaugu c 21
<210> 6066
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6066
guaaacacgu ugacuccuga g 21
<210> 6067
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6067
guaaaugcgu cccuguacag a 21
<210> 6068
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6068
guaacacggc gauuucagaa a 21
<210> 6069
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6069
guaaccgggu gucucaggca c 21
<210> 6070
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6070
guaagacauu caggcuacaa a 21
<210> 6071
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6071
guaagacccc aucucuuaaa a 21
<210> 6072
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6072
guacaaaccc accucgaaag a 21
<210> 6073
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6073
guacaaagau uauuugcacg a 21
<210> 6074
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6074
guacaacucu gaacugagaa a 21
<210> 6075
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6075
guacacagug uacaacucug a 21
<210> 6076
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6076
guacacugug uacauuuggc a 21
<210> 6077
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6077
guacagauag uggggauuuu u 21
<210> 6078
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6078
guacagggac gcauuuacgu g 21
<210> 6079
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6079
guacauaaag aagaggcauu u 21
<210> 6080
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6080
guacccagcu gauuuuuaac u 21
<210> 6081
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6081
guaccuuccu uaagccagga a 21
<210> 6082
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6082
guagccugaa ugucuuacug u 21
<210> 6083
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6083
guaggggguu auugccucug a 21
<210> 6084
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6084
guaggggucg ggaggauggg c 21
<210> 6085
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6085
guauagaagg uuuuuguagc c 21
<210> 6086
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6086
guaugagugg cuucugggag a 21
<210> 6087
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6087
guauguauga guggcuucug g 21
<210> 6088
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6088
guauguguuu aaaacaugca c 21
<210> 6089
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6089
guauuucuga aauagggucu u 21
<210> 6090
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6090
guauuuguuc agugacuauu c 21
<210> 6091
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6091
gucaaacgau ccagacugga g 21
<210> 6092
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6092
gucaaccugc cccucucugu c 21
<210> 6093
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6093
gucaacgugu uuaccucuuc u 21
<210> 6094
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6094
gucaaugaau gccggggaca g 21
<210> 6095
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6095
gucacaaggg auuggcaauu g 21
<210> 6096
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6096
gucacccccg aaucaugacc c 21
<210> 6097
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6097
gucacccuua auauuuauua a 21
<210> 6098
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6098
gucacggugg agagaaacuc a 21
<210> 6099
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6099
gucacugaac aaauacagca a 21
<210> 6100
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6100
gucacugguc acccuuaaua u 21
<210> 6101
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6101
gucacugucu cuccggacau c 21
<210> 6102
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6102
gucacuuuuu aaaccacugu a 21
<210> 6103
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6103
gucagacucc cgcgugaaga u 21
<210> 6104
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6104
gucaggacac cagccuggug c 21
<210> 6105
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6105
gucaggccca gagaagcaag u 21
<210> 6106
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6106
gucagucugg aggaugacgu g 21
<210> 6107
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6107
gucauccucc agacugacca u 21
<210> 6108
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6108
gucauccugg uccccccggg c 21
<210> 6109
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6109
gucaugauuc gggggugaca g 21
<210> 6110
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6110
guccaguucg ugcaaauaau c 21
<210> 6111
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6111
guccccaggg acaaaacacu g 21
<210> 6112
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6112
guccccccgg gccuguuucu c 21
<210> 6113
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6113
guccccggca uucauugaca c 21
<210> 6114
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6114
guccccguug uauguaugag u 21
<210> 6115
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6115
gucccgguca accugccccu c 21
<210> 6116
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6116
gucccgucaa acgauccaga c 21
<210> 6117
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6117
gucccguccc ugcccagaac c 21
<210> 6118
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6118
gucccguugg ugccaucugc u 21
<210> 6119
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6119
gucccugccc agaacccuuc c 21
<210> 6120
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6120
gucccugggg acaauugcca a 21
<210> 6121
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6121
gucccuguac agauaguggg g 21
<210> 6122
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6122
guccgaagcc uguucugccu c 21
<210> 6123
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6123
guccgcccac cuagugcuuc c 21
<210> 6124
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6124
guccggagag acagugacag c 21
<210> 6125
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6125
guccucacgg ccaagguaac c 21
<210> 6126
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6126
guccugacag ccacaccugg g 21
<210> 6127
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6127
gucggaaaug aucuggcuga a 21
<210> 6128
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6128
gucgggagga ugggcaccag g 21
<210> 6129
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6129
gucgucuuua uguccgccca c 21
<210> 6130
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6130
gucgugagcu augauuaugc c 21
<210> 6131
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6131
gucgugugug uugggauggg a 21
<210> 6132
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6132
gucguugaug gguauguguu u 21
<210> 6133
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6133
gucuagcaag gcuugcauag a 21
<210> 6134
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6134
gucucaggaa ggguucuggg c 21
<210> 6135
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6135
gucucaggca cuuaauaaau a 21
<210> 6136
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6136
gucuccuugc acuuucucag u 21
<210> 6137
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6137
gucucggugc caccacggau u 21
<210> 6138
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6138
gucucuccgg acaucagugc a 21
<210> 6139
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6139
gucugacgga ggcugucacu g 21
<210> 6140
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6140
gucuggagga ugacguggcg u 21
<210> 6141
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6141
gucuggaucg uuugacggga c 21
<210> 6142
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6142
gucuggccaa auucauuuuu u 21
<210> 6143
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6143
gucuucucug ucuuugaaua a 21
<210> 6144
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6144
gucuuuaugu ccgcccaccu a 21
<210> 6145
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6145
gucuuucgag guggguuugu a 21
<210> 6146
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6146
gucuuugaau aaaacaaggc c 21
<210> 6147
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6147
gugaacaucu gccuggaguc c 21
<210> 6148
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6148
gugaagaugu cacaagggau u 21
<210> 6149
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6149
gugaaggaua agagaaacag g 21
<210> 6150
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6150
gugaauaucg agaacugcca u 21
<210> 6151
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6151
gugaaugagu uuggucucgg u 21
<210> 6152
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6152
gugaauggcu uggaggcauu u 21
<210> 6153
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6153
gugacacaau ccucaaacau g 21
<210> 6154
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6154
gugacaccca ucucccagaa g 21
<210> 6155
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6155
gugacagccu ccgucagacu c 21
<210> 6156
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6156
gugacagggc aaaggcuaac c 21
<210> 6157
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6157
gugacaucuu cacgcgggag u 21
<210> 6158
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6158
gugaccagug acucaggcuc u 21
<210> 6159
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6159
gugacuauuc ucggggcccu g 21
<210> 6160
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6160
gugacucagg cucugccucu g 21
<210> 6161
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6161
gugagccacu gcgcccggcc u 21
<210> 6162
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6162
gugagcuaug auuaugccac u 21
<210> 6163
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6163
gugaggacac guggccugca c 21
<210> 6164
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6164
gugaggcacc ugugucuggc c 21
<210> 6165
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6165
gugauaagcc uuucugguuu c 21
<210> 6166
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6166
gugauccagc ucagccuccc a 21
<210> 6167
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6167
gugaucguga auaucgagaa c 21
<210> 6168
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6168
gugcaaacau aacaaaaaau c 21
<210> 6169
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6169
gugcaacagu aacacggcga u 21
<210> 6170
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6170
gugcaacgcu uuuugggaga a 21
<210> 6171
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6171
gugcaaggag accacgggaa u 21
<210> 6172
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6172
gugcaggcca cguguccuca c 21
<210> 6173
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6173
gugcagggaa ccgugauaag c 21
<210> 6174
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6174
gugcaucagc agcccauggc c 21
<210> 6175
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6175
gugcauguuu uaaacacaua c 21
<210> 6176
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6176
gugccaccac ggauucagcc a 21
<210> 6177
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6177
gugccaccgu acccagcuga u 21
<210> 6178
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6178
gugccaucug cuguugugug u 21
<210> 6179
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6179
gugcccaucc ucccgacccc u 21
<210> 6180
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6180
gugcccaugc aauggcuugg g 21
<210> 6181
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6181
gugccugaga cacccgguua c 21
<210> 6182
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6182
gugcuccgaa accagaaagg c 21
<210> 6183
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6183
gugcuuccac uucuaugcaa a 21
<210> 6184
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6184
guggaagcac uaggugggcg g 21
<210> 6185
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6185
guggagagaa acucaaaacu u 21
<210> 6186
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6186
guggagguug cagugagcca u 21
<210> 6187
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6187
guggaugagg cagggccagg g 21
<210> 6188
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6188
guggcaccga gaccaaacuc a 21
<210> 6189
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6189
guggcaucau uuggugaaug a 21
<210> 6190
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6190
guggccugca cccaggugug g 21
<210> 6191
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6191
guggcgugaa caucugccug g 21
<210> 6192
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6192
guggcuguca ggacaccagc c 21
<210> 6193
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6193
guggcuucug ggagaugggu g 21
<210> 6194
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6194
guggcuuuca acacacaaca g 21
<210> 6195
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6195
gugggaggau gguuugagcu c 21
<210> 6196
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6196
gugggcggac auaaagacga c 21
<210> 6197
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6197
guggggauuu uuuguuaugu u 21
<210> 6198
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6198
guggguaggg gucgggagga u 21
<210> 6199
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6199
gugggucaug auucgggggu g 21
<210> 6200
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6200
guggguuugu accuuccuua a 21
<210> 6201
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6201
guggucuccu ugcacuuucu c 21
<210> 6202
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6202
gugguggcac cgagaccaaa c 21
<210> 6203
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6203
gugguuuaaa aagugacacc c 21
<210> 6204
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6204
guguacaacu cugaacugag a 21
<210> 6205
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6205
guguaggggg uuauugccuc u 21
<210> 6206
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6206
gugucaauga augccgggga c 21
<210> 6207
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6207
gugucacggu ggagagaaac u 21
<210> 6208
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6208
gugucacuuu uuaaaccacu g 21
<210> 6209
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6209
gugucauccu gguccccccg g 21
<210> 6210
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6210
guguccucac ggccaaggua a 21
<210> 6211
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6211
guguccugac agccacaccu g 21
<210> 6212
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6212
gugucuggcc aaauucauuu u 21
<210> 6213
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6213
gugucuuucg agguggguuu g 21
<210> 6214
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6214
gugugcaacg cuuuuuggga g 21
<210> 6215
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6215
guguggcugu caggacacca g 21
<210> 6216
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6216
guguguguug ggaugggauc c 21
<210> 6217
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6217
guguguugaa agccacuugc u 21
<210> 6218
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6218
guguguuggg augggauccc a 21
<210> 6219
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6219
guguuacugu ugcacugaug u 21
<210> 6220
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6220
guguugaaag ccacuugcuu c 21
<210> 6221
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6221
guguugggau gggaucccag g 21
<210> 6222
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6222
guguuuaaaa caugcacggu g 21
<210> 6223
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6223
guguuuaccu cuucuaugca a 21
<210> 6224
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6224
guguuuuguc ccuggggaca a 21
<210> 6225
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6225
guuaaaaauc agcuggguac g 21
<210> 6226
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6226
guuaccuugg ccgugaggac a 21
<210> 6227
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6227
guuacuguug cacugauguc c 21
<210> 6228
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6228
guuagccuuu gcccugucac c 21
<210> 6229
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6229
guuauuauuu ugcacuguuu u 21
<210> 6230
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6230
guuauugccu cugaaaugcc u 21
<210> 6231
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6231
guucacgcca cgucauccuc c 21
<210> 6232
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6232
guucagaguu guacacugug u 21
<210> 6233
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6233
guucaggagu uggagaccag g 21
<210> 6234
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6234
guucagugac uauucucggg g 21
<210> 6235
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6235
guucucgaua uucacgauca c 21
<210> 6236
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6236
guucugccuc ccagaugaau a 21
<210> 6237
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6237
guucugggca gggacgggac u 21
<210> 6238
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6238
guucuuucug aaaucgccgu g 21
<210> 6239
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6239
guugaaagcc acuugcuucu c 21
<210> 6240
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6240
guugaccggg acuucaaagc c 21
<210> 6241
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6241
guugacuccu gaguuuaggg g 21
<210> 6242
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6242
guugaugggu auguguuuaa a 21
<210> 6243
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6243
guugcacaca guccaguucg u 21
<210> 6244
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6244
guugcacuga uguccggaga g 21
<210> 6245
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6245
guugcucagg ccuggucucc a 21
<210> 6246
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6246
guugcuguau uuguucagug a 21
<210> 6247
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6247
guuggagacc aggccugagc a 21
<210> 6248
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6248
guugggaugg gaucccaggc c 21
<210> 6249
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6249
guugggauuu ugguuucuuc c 21
<210> 6250
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6250
guuggugcca ucugcuguug u 21
<210> 6251
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6251
guuguacacu guguacauuu g 21
<210> 6252
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6252
guuguaugua ugaguggcuu c 21
<210> 6253
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6253
guuguauuuc ugaaauaggg u 21
<210> 6254
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6254
guuguguguu gaaagccacu u 21
<210> 6255
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6255
guuuaaaaag ugacacccau c 21
<210> 6256
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6256
guuuaaaaca ugcacgguga g 21
<210> 6257
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6257
guuuaccucu ucuaugcaag c 21
<210> 6258
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6258
guuuaggggu uuggcuuaga g 21
<210> 6259
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6259
guuucaacca auauacaaag u 21
<210> 6260
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6260
guuucggagc acguaaaugc g 21
<210> 6261
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6261
guuucucucc accgugacac a 21
<210> 6262
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6262
guuucucuua uccuucacga g 21
<210> 6263
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6263
guuucuuccu uuccucguga a 21
<210> 6264
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6264
guuugacggg acuucagguu c 21
<210> 6265
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6265
guuugagcuc aggcauuuga g 21
<210> 6266
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6266
guuugaggau ugugucacgg u 21
<210> 6267
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6267
guuugcacuu uguauauugg u 21
<210> 6268
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6268
guuuggcuua gagauuggug g 21
<210> 6269
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6269
guuuggucuc ggugccacca c 21
<210> 6270
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6270
guuuguaccu uccuuaagcc a 21
<210> 6271
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6271
guuuuaaaca cauacccauc a 21
<210> 6272
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6272
guuuuauuca aagacagaga a 21
<210> 6273
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6273
guuuucuguc guguguguug g 21
<210> 6274
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6274
guuuugaguu ucucuccacc g 21
<210> 6275
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6275
guuuuguccc uggggacaau u 21
<210> 6276
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6276
guuuuuguag agaugggauc u 21
<210> 6277
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6277
guuuuuguag ccugaauguc u 21
<210> 6278
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6278
uaaaaaauga auuuggccag a 21
<210> 6279
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6279
uaaaaaguga cacccaucuc c 21
<210> 6280
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6280
uaaaaaucag cuggguacgg u 21
<210> 6281
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6281
uaaaacaaag cucuggcagg c 21
<210> 6282
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6282
uaaaacaagg ccggcgaggu c 21
<210> 6283
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6283
uaaaacaugc acggugaggc c 21
<210> 6284
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6284
uaaacacaua cccaucaacg a 21
<210> 6285
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6285
uaaacacguu gacuccugag u 21
<210> 6286
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6286
uaaacucagg agucaacgug u 21
<210> 6287
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6287
uaaagaagag gcauuucaga g 21
<210> 6288
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6288
uaaagacgac aauggcaguu c 21
<210> 6289
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6289
uaaauaaauc cuccagucug g 21
<210> 6290
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6290
uaaauauuaa gggugaccag u 21
<210> 6291
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6291
uaaauccucc agucuggauc g 21
<210> 6292
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6292
uaaaugcguc ccuguacaga u 21
<210> 6293
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6293
uaacaaaaaa uccccacuau c 21
<210> 6294
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6294
uaacacaaau gccaaaugua c 21
<210> 6295
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6295
uaacacggcg auuucagaaa g 21
<210> 6296
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6296
uaacccccua cacagggccc c 21
<210> 6297
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6297
uaaccgggug ucucaggcac u 21
<210> 6298
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6298
uaaccuggcu gucuagcaag g 21
<210> 6299
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6299
uaacuuuuug guuuuuguag a 21
<210> 6300
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6300
uaagacauuc aggcuacaaa a 21
<210> 6301
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6301
uaagagaaac aggcccgggg g 21
<210> 6302
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6302
uaagccaaac cccuaaacuc a 21
<210> 6303
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6303
uaagccagga aagggauuca u 21
<210> 6304
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6304
uaagccuuuc ugguuucgga g 21
<210> 6305
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6305
uaagggugac cagugacuca g 21
<210> 6306
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6306
uaagugccug agacacccgg u 21
<210> 6307
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6307
uaauaaauau uaagggugac c 21
<210> 6308
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6308
uaauauuuau uaagugccug a 21
<210> 6309
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6309
uaaucauagc ucacgacagc c 21
<210> 6310
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6310
uaauugauca caguaagaca u 21
<210> 6311
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6311
uacaaaccca ccucgaaaga c 21
<210> 6312
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6312
uacaaagauu auuugcacga a 21
<210> 6313
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6313
uacaacgggg acaucauucu c 21
<210> 6314
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6314
uacaacucug aacugagaaa g 21
<210> 6315
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6315
uacacagggc cccgagaaua g 21
<210> 6316
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6316
uacacagugu acaacucuga a 21
<210> 6317
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6317
uacacugugu acauuuggca u 21
<210> 6318
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6318
uacagauagu ggggauuuuu u 21
<210> 6319
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6319
uacagcaacc aggguuugca a 21
<210> 6320
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6320
uacaggcgug aggcaccugu g 21
<210> 6321
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6321
uacagggacg cauuuacgug c 21
<210> 6322
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6322
uacagugguu uaaaaaguga c 21
<210> 6323
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6323
uacauaaaga agaggcauuu c 21
<210> 6324
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6324
uacauacaac ggggacauca u 21
<210> 6325
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6325
uacccacuuc cauucccgug g 21
<210> 6326
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6326
uacccagcug auuuuuaacu u 21
<210> 6327
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6327
uacccaucaa cgacaagauu g 21
<210> 6328
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6328
uaccucuucu augcaagccu u 21
<210> 6329
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6329
uaccuuccuu aagccaggaa a 21
<210> 6330
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6330
uaccuuggcc gugaggacac g 21
<210> 6331
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6331
uacgugcucc gaaaccagaa a 21
<210> 6332
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6332
uacuauguug cccaggcugg a 21
<210> 6333
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6333
uacuguugca cugauguccg g 21
<210> 6334
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6334
uagaagaggu aaacacguug a 21
<210> 6335
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6335
uagaagguuu uuguagccug a 21
<210> 6336
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6336
uagaagugga agcacuaggu g 21
<210> 6337
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6337
uagacagcca gguuagccuu u 21
<210> 6338
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6338
uagagauggg aucucgcuuu g 21
<210> 6339
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6339
uagagauugg uggaugaggc a 21
<210> 6340
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6340
uagcaaggcu ugcauagaag a 21
<210> 6341
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6341
uagccugaau gucuuacugu g 21
<210> 6342
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6342
uagccuuugc ccugucaccc c 21
<210> 6343
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6343
uagcucacga cagccucaaa u 21
<210> 6344
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6344
uaggggguua uugccucuga a 21
<210> 6345
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6345
uaggggucgg gaggaugggc a 21
<210> 6346
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6346
uagggguuug gcuuagagau u 21
<210> 6347
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6347
uaggugggcg gacauaaaga c 21
<210> 6348
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6348
uaguaagacc ccaucucuua a 21
<210> 6349
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6349
uagucacuga acaaauacag c 21
<210> 6350
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6350
uagugcuucc acuucuaugc a 21
<210> 6351
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6351
uaguggggau uuuuuguuau g 21
<210> 6352
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6352
uaguuguauu ucugaaauag g 21
<210> 6353
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6353
uauaaaacaa agcucuggca g 21
<210> 6354
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6354
uauacagugg uuuaaaaagu g 21
<210> 6355
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6355
uauagaaggu uuuuguagcc u 21
<210> 6356
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6356
uauauaaaac aaagcucugg c 21
<210> 6357
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6357
uauauauuua uucaucuggg a 21
<210> 6358
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6358
uauauuuauu caucugggag g 21
<210> 6359
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6359
uauccuucac gaggaaagga a 21
<210> 6360
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6360
uaucgagaac ugccauuguc g 21
<210> 6361
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6361
uaugaguggc uucugggaga u 21
<210> 6362
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6362
uaugauuaug ccacugcuuu c 21
<210> 6363
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6363
uaugcaaaug ccuccaagcc a 21
<210> 6364
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6364
uaugcaagcc uugcuagaca g 21
<210> 6365
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6365
uaugccacug cuuuccagcc u 21
<210> 6366
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6366
uauguaugag uggcuucugg g 21
<210> 6367
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6367
uauguccgcc caccuagugc u 21
<210> 6368
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6368
uauguguuua aaacaugcac g 21
<210> 6369
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6369
uauuaagggu gaccagugac u 21
<210> 6370
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6370
uauuaagugc cugagacacc c 21
<210> 6371
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6371
uauuauuuug cacuguuuuc u 21
<210> 6372
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6372
uauucaaaga cagagaagac c 21
<210> 6373
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6373
uauucacgau cacggcuuug a 21
<210> 6374
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6374
uauucaucug ggaggcagaa c 21
<210> 6375
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6375
uauucucggg gcccugugua g 21
<210> 6376
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6376
uauugccucu gaaaugccuc u 21
<210> 6377
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6377
uauuuauuaa gugccugaga c 21
<210> 6378
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6378
uauuuauuca ucugggaggc a 21
<210> 6379
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6379
uauuuauuuu ugcaaacccu g 21
<210> 6380
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6380
uauuucugaa auagggucuu c 21
<210> 6381
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6381
uauuugcacg aacuggacug u 21
<210> 6382
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6382
uauuuguuca gugacuauuc u 21
<210> 6383
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6383
uauuuugcac uguuuucugu c 21
<210> 6384
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6384
uauuuuugca aacccugguu g 21
<210> 6385
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6385
ucaaaacuuc cuggagagaa a 21
<210> 6386
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6386
ucaaacaugg aagaugaaag g 21
<210> 6387
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6387
ucaaacgauc cagacuggag g 21
<210> 6388
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6388
ucaaagacag agaagaccaa a 21
<210> 6389
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6389
ucaaagccgu gaucgugaau a 21
<210> 6390
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6390
ucaaaugccu gagcucaaac c 21
<210> 6391
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6391
ucaacacaca acagcagaug g 21
<210> 6392
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6392
ucaaccugcc ccucucuguc c 21
<210> 6393
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6393
ucaacgacaa gauuggggaa g 21
<210> 6394
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6394
ucaacguguu uaccucuucu a 21
<210> 6395
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6395
ucaagugauc cagcucagcc u 21
<210> 6396
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6396
ucaaugaaug ccggggacag a 21
<210> 6397
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6397
ucacaaggga uuggcaauug u 21
<210> 6398
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6398
ucacaggcac gugccaccgu a 21
<210> 6399
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6399
ucacaguaag acauucaggc u 21
<210> 6400
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6400
ucaccaaaug augccacuuc c 21
<210> 6401
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6401
ucacccccga aucaugaccc a 21
<210> 6402
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6402
ucacccuuaa uauuuauuaa g 21
<210> 6403
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6403
ucaccgugca uguuuuaaac a 21
<210> 6404
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6404
ucacgacagc cucaaaugcc u 21
<210> 6405
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6405
ucacgaggaa aggaagaaac c 21
<210> 6406
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6406
ucacgaucac ggcuuugaag u 21
<210> 6407
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6407
ucacgccacg ucauccucca g 21
<210> 6408
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6408
ucacgcggga gucugacgga g 21
<210> 6409
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6409
ucacggccaa gguaaccggg u 21
<210> 6410
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6410
ucacggcuuu gaagucccgg u 21
<210> 6411
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6411
ucacggugga gagaaacuca a 21
<210> 6412
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6412
ucacugaaca aauacagcaa c 21
<210> 6413
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6413
ucacugucuc uccggacauc a 21
<210> 6414
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6414
ucacuucccc aaucuugucg u 21
<210> 6415
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6415
ucacuuuuua aaccacugua u 21
<210> 6416
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6416
ucagacuccc gcgugaagau g 21
<210> 6417
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6417
ucagaggcaa uaacccccua c 21
<210> 6418
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6418
ucagaguugu acacugugua c 21
<210> 6419
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6419
ucagcagccc auggccucug g 21
<210> 6420
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6420
ucagccagau cauuuccgac g 21
<210> 6421
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6421
ucagccucgc caugccuggc c 21
<210> 6422
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6422
ucagcugggu acgguggcac g 21
<210> 6423
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6423
ucaggaaggg uucugggcag g 21
<210> 6424
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6424
ucaggacacc agccuggugc c 21
<210> 6425
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6425
ucaggaguca acguguuuac c 21
<210> 6426
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6426
ucaggaguug gagaccaggc c 21
<210> 6427
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6427
ucaggcacuu aauaaauauu a 21
<210> 6428
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6428
ucaggcauuu gaggcugucg u 21
<210> 6429
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6429
ucaggcccag agaagcaagu g 21
<210> 6430
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6430
ucaggccugg ucuccaacuc c 21
<210> 6431
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6431
ucaggcuaca aaaaccuucu a 21
<210> 6432
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6432
ucaggcucug ccucugggaa g 21
<210> 6433
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6433
ucagguucuu ucugaaaucg c 21
<210> 6434
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6434
ucagucugga ggaugacgug g 21
<210> 6435
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6435
ucagugacua uucucggggc c 21
<210> 6436
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6436
ucagugcaac aguaacacgg c 21
<210> 6437
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6437
ucaguucaga guuguacacu g 21
<210> 6438
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6438
ucauacauac aacggggaca u 21
<210> 6439
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6439
ucauagcuca cgacagccuc a 21
<210> 6440
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6440
ucauccacca aucucuaagc c 21
<210> 6441
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6441
ucauccucca gacugaccau c 21
<210> 6442
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6442
ucauccuggu ccccccgggc c 21
<210> 6443
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6443
ucaucuggga ggcagaacag g 21
<210> 6444
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6444
ucaucuucca uguuugagga u 21
<210> 6445
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6445
ucaugaccca cccagugucu u 21
<210> 6446
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6446
ucaugauucg ggggugacag g 21
<210> 6447
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6447
ucauggcguc ggaaaugauc u 21
<210> 6448
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6448
ucauucacca aaugaugcca c 21
<210> 6449
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6449
ucauucuccc aaaaagcguu g 21
<210> 6450
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6450
ucauugacac gggcuuuccc u 21
<210> 6451
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6451
ucauuuccga cgccaugaau c 21
<210> 6452
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6452
ucauuuggug aaugaguuug g 21
<210> 6453
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6453
ucauuuuuua agagaugggg u 21
<210> 6454
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6454
uccaacuccu gaacucaagu g 21
<210> 6455
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6455
uccaagccau ucacuucccc a 21
<210> 6456
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6456
uccaccaauc ucuaagccaa a 21
<210> 6457
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6457
uccaccguga cacaauccuc a 21
<210> 6458
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6458
uccacuucua ugcaaaugcc u 21
<210> 6459
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6459
uccaggaagu uuugaguuuc u 21
<210> 6460
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6460
uccaggcaga uguucacgcc a 21
<210> 6461
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6461
uccagucugg aucguuugac g 21
<210> 6462
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6462
uccaguucgu gcaaauaauc u 21
<210> 6463
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6463
uccauguuug aggauugugu c 21
<210> 6464
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6464
uccauucccg uggucuccuu g 21
<210> 6465
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6465
uccauuucuc uccaggaagu u 21
<210> 6466
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6466
ucccaaaaag cguugcacac a 21
<210> 6467
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6467
ucccaacaca cacgacagaa a 21
<210> 6468
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6468
ucccaaccca agccauugca u 21
<210> 6469
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6469
ucccaccuca gccucgccau g 21
<210> 6470
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6470
ucccagaagc cacucauaca u 21
<210> 6471
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6471
ucccagaggc agagccugag u 21
<210> 6472
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6472
ucccaggcca gggaaagccc g 21
<210> 6473
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6473
ucccauccca acacacacga c 21
<210> 6474
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6474
ucccaucucu acaaaaacca a 21
<210> 6475
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6475
uccccaaucu ugucguugau g 21
<210> 6476
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6476
uccccacuau cuguacaggg a 21
<210> 6477
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6477
uccccaggga caaaacacug u 21
<210> 6478
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6478
uccccggcau ucauugacac g 21
<210> 6479
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6479
uccccguugu auguaugagu g 21
<210> 6480
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6480
uccccucccc uuucaucuuc c 21
<210> 6481
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6481
uccccuuuca ucuuccaugu u 21
<210> 6482
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6482
ucccgacccc uacccacuuc c 21
<210> 6483
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6483
ucccgcguga agaugucaca a 21
<210> 6484
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6484
ucccggucaa ccugccccuc u 21
<210> 6485
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6485
ucccgucaaa cgauccagac u 21
<210> 6486
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6486
ucccgucccu gcccagaacc c 21
<210> 6487
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6487
ucccgugguc uccuugcacu u 21
<210> 6488
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6488
ucccguuggu gccaucugcu g 21
<210> 6489
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6489
ucccugccca gaacccuucc u 21
<210> 6490
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6490
ucccuggccu gggaucccau c 21
<210> 6491
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6491
ucccugggga caauugccaa u 21
<210> 6492
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6492
ucccuguaca gauagugggg a 21
<210> 6493
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6493
ucccuuguga caucuucacg c 21
<210> 6494
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6494
ucccuuuccu ggcuuaagga a 21
<210> 6495
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6495
uccgaaacca gaaaggcuua u 21
<210> 6496
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6496
uccgaagccu guucugccuc c 21
<210> 6497
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6497
uccgacgcca ugaaucccuu u 21
<210> 6498
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6498
uccgcccacc uagugcuucc a 21
<210> 6499
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6499
uccggacauc agugcaacag u 21
<210> 6500
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6500
uccggagaga cagugacagc c 21
<210> 6501
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6501
uccgucagac ucccgcguga a 21
<210> 6502
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6502
uccguggugg caccgagacc a 21
<210> 6503
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6503
uccucaaaca uggaagauga a 21
<210> 6504
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6504
uccucacggc caagguaacc g 21
<210> 6505
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6505
uccuccaguc uggaucguuu g 21
<210> 6506
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6506
uccucccacc ucagccucgc c 21
<210> 6507
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6507
uccucccgac cccuacccac u 21
<210> 6508
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6508
uccucgugaa ggauaagaga a 21
<210> 6509
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6509
uccugaacuc aagugaucca g 21
<210> 6510
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6510
uccugacagc cacaccuggg u 21
<210> 6511
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6511
uccugagacc ucgccggccu u 21
<210> 6512
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6512
uccugaguuu agggguuugg c 21
<210> 6513
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6513
uccuggagag aaauggaggu g 21
<210> 6514
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6514
uccuggcuua aggaagguac a 21
<210> 6515
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6515
uccugguccc cccgggccug u 21
<210> 6516
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6516
uccuuaagcc aggaaaggga u 21
<210> 6517
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6517
uccuucacga ggaaaggaag a 21
<210> 6518
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6518
uccuugcacu uucucaguuc a 21
<210> 6519
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6519
uccuuuccuc gugaaggaua a 21
<210> 6520
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6520
ucgaaagaca cugggugggu c 21
<210> 6521
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6521
ucgagaacug ccauugucgu c 21
<210> 6522
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6522
ucgagguggg uuuguaccuu c 21
<210> 6523
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6523
ucgauauuca cgaucacggc u 21
<210> 6524
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6524
ucgaucaugg cucacugcaa c 21
<210> 6525
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6525
ucgccaugcc uggccagagg c 21
<210> 6526
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6526
ucgccggccu uguuuuauuc a 21
<210> 6527
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6527
ucgccguguu acuguugcac u 21
<210> 6528
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6528
ucgcuuuguu gcucaggccu g 21
<210> 6529
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6529
ucggaaauga ucuggcugaa u 21
<210> 6530
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6530
ucggacagug cccaugcaau g 21
<210> 6531
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6531
ucggagcacg uaaaugcguc c 21
<210> 6532
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6532
ucgggaggau gggcaccagg c 21
<210> 6533
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6533
ucggggcccu guguaggggg u 21
<210> 6534
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6534
ucggggguga cagggcaaag g 21
<210> 6535
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6535
ucggugccac cacggauuca g 21
<210> 6536
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6536
ucgucuuuau guccgcccac c 21
<210> 6537
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6537
ucgugaagga uaagagaaac a 21
<210> 6538
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6538
ucgugaauau cgagaacugc c 21
<210> 6539
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6539
ucgugagcua ugauuaugcc a 21
<210> 6540
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6540
ucgugugugu ugggauggga u 21
<210> 6541
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6541
ucguugaugg guauguguuu a 21
<210> 6542
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6542
ucguuugacg ggacuucagg u 21
<210> 6543
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6543
ucuaagccaa accccuaaac u 21
<210> 6544
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6544
ucuagcaagg cuugcauaga a 21
<210> 6545
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6545
ucuauacagu gguuuaaaaa g 21
<210> 6546
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6546
ucuaugcaaa ugccuccaag c 21
<210> 6547
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6547
ucuaugcaag ccuugcuaga c 21
<210> 6548
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6548
ucuauuuauu uuugcaaacc c 21
<210> 6549
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6549
ucucaggaag gguucugggc a 21
<210> 6550
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6550
ucucaggcac uuaauaaaua u 21
<210> 6551
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6551
ucucaguuca gaguuguaca c 21
<210> 6552
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6552
ucuccaccgu gacacaaucc u 21
<210> 6553
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6553
ucuccaggaa guuuugaguu u 21
<210> 6554
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6554
ucucccaaaa agcguugcac a 21
<210> 6555
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6555
ucucccagaa gccacucaua c 21
<210> 6556
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6556
ucuccggaca ucagugcaac a 21
<210> 6557
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6557
ucuccuugca cuuucucagu u 21
<210> 6558
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6558
ucucgauauu cacgaucacg g 21
<210> 6559
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6559
ucucgcuuug uugcucaggc c 21
<210> 6560
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6560
ucucggggcc cuguguaggg g 21
<210> 6561
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6561
ucucggugcc accacggauu c 21
<210> 6562
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6562
ucucuaagcc aaaccccuaa a 21
<210> 6563
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6563
ucucuccacc gugacacaau c 21
<210> 6564
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6564
ucucuccagg aaguuuugag u 21
<210> 6565
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6565
ucucuccgga caucagugca a 21
<210> 6566
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6566
ucucugggcc ugacaucccc u 21
<210> 6567
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6567
ucucuguccc cggcauucau u 21
<210> 6568
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6568
ucucugucuu ugaauaaaac a 21
<210> 6569
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6569
ucucuuaaaa aaugaauuug g 21
<210> 6570
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6570
ucucuuaucc uucacgagga a 21
<210> 6571
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6571
ucugaaauag ggucuucauc u 21
<210> 6572
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6572
ucugaaaucg ccguguuacu g 21
<210> 6573
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6573
ucugaaaugc cucuucuuua u 21
<210> 6574
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6574
ucugaacuga gaaagugcaa g 21
<210> 6575
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6575
ucugacggag gcugucacug u 21
<210> 6576
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6576
ucugccucug ggaaguggca u 21
<210> 6577
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6577
ucugccugga gucccguccc u 21
<210> 6578
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6578
ucugcuguug uguguugaaa g 21
<210> 6579
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6579
ucuggaggau gacguggcgu g 21
<210> 6580
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6580
ucuggaucgu uugacgggac u 21
<210> 6581
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6581
ucuggcaggc aaugcuuugg u 21
<210> 6582
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6582
ucuggccagg cauggcgagg c 21
<210> 6583
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6583
ucuggcugaa uccguggugg c 21
<210> 6584
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6584
ucugggaagu ggcaucauuu g 21
<210> 6585
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6585
ucugggagau gggugucacu u 21
<210> 6586
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6586
ucugggaggc agaacaggcu u 21
<210> 6587
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6587
ucugggcagg gacgggacuc c 21
<210> 6588
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6588
ucugggccug acauccccuc c 21
<210> 6589
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6589
ucugguuucg gagcacguaa a 21
<210> 6590
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6590
ucuguacagg gacgcauuua c 21
<210> 6591
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6591
ucuguccccg gcauucauug a 21
<210> 6592
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6592
ucugucgugu guguugggau g 21
<210> 6593
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6593
ucugucuuug aauaaaacaa g 21
<210> 6594
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6594
ucuuaaaaaa ugaauuuggc c 21
<210> 6595
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6595
ucuuauccuu cacgaggaaa g 21
<210> 6596
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6596
ucuucacgcg ggagucugac g 21
<210> 6597
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6597
ucuuccaugu uugaggauug u 21
<210> 6598
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6598
ucuuccuuuc cucgugaagg a 21
<210> 6599
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6599
ucuucuaugc aagccuugcu a 21
<210> 6600
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6600
ucuucucugu cuuugaauaa a 21
<210> 6601
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6601
ucuugucguu gauggguaug u 21
<210> 6602
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6602
ucuuuauguc cgcccaccua g 21
<210> 6603
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6603
ucuuucgagg uggguuugua c 21
<210> 6604
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6604
ucuuucugaa aucgccgugu u 21
<210> 6605
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6605
ucuuugaaua aaacaaggcc g 21
<210> 6606
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6606
ucuuuguaca uaaagaagag g 21
<210> 6607
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6607
ugaaagccac uugcuucucu g 21
<210> 6608
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6608
ugaaagggga ggggauguca g 21
<210> 6609
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6609
ugaaaucgcc guguuacugu u 21
<210> 6610
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6610
ugaaaugccu cuucuuuaug u 21
<210> 6611
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6611
ugaacaaaua cagcaaccag g 21
<210> 6612
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6612
ugaacaucug ccuggagucc c 21
<210> 6613
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6613
ugaacugaga aagugcaagg a 21
<210> 6614
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6614
ugaagacccu auuucagaaa u 21
<210> 6615
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6615
ugaagauguc acaagggauu g 21
<210> 6616
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6616
ugaaggauaa gagaaacagg c 21
<210> 6617
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6617
ugaagucccg gucaaccugc c 21
<210> 6618
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6618
ugaagucccg ucaaacgauc c 21
<210> 6619
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6619
ugaauaaaac aaggccggcg a 21
<210> 6620
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6620
ugaauaucga gaacugccau u 21
<210> 6621
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6621
ugaaucccuu uccuggcuua a 21
<210> 6622
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6622
ugaauccgug guggcaccga g 21
<210> 6623
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6623
ugaaugaguu uggucucggu g 21
<210> 6624
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6624
ugaaugccgg ggacagagag g 21
<210> 6625
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6625
ugaauggcuu ggaggcauuu g 21
<210> 6626
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6626
ugaauuuggc cagacacagg u 21
<210> 6627
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6627
ugacacaauc cucaaacaug g 21
<210> 6628
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6628
ugacacccau cucccagaag c 21
<210> 6629
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6629
ugacaccucc auuucucucc a 21
<210> 6630
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6630
ugacacgggc uuucccuggc c 21
<210> 6631
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6631
ugacagccac accugggugc a 21
<210> 6632
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6632
ugacagccuc cgucagacuc c 21
<210> 6633
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6633
ugacagggca aaggcuaacc u 21
<210> 6634
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6634
ugacaucccc uccccuuuca u 21
<210> 6635
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6635
ugacaucuuc acgcgggagu c 21
<210> 6636
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6636
ugaccaguga cucaggcucu g 21
<210> 6637
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6637
ugacccaccc agugucuuuc g 21
<210> 6638
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6638
ugaccgggac uucaaagccg u 21
<210> 6639
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6639
ugacggaggc ugucacuguc u 21
<210> 6640
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6640
ugacgggacu ucagguucuu u 21
<210> 6641
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6641
ugacguggcg ugaacaucug c 21
<210> 6642
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6642
ugacuauucu cggggcccug u 21
<210> 6643
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6643
ugacuccuga guuuaggggu u 21
<210> 6644
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6644
ugagaaagug caaggagacc a 21
<210> 6645
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6645
ugagacaccc gguuaccuug g 21
<210> 6646
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6646
ugagaccucg ccggccuugu u 21
<210> 6647
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6647
ugagcaacaa agcgagaucc c 21
<210> 6648
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6648
ugagcuauga uuaugccacu g 21
<210> 6649
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6649
ugagcucagg cauuugaggc u 21
<210> 6650
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6650
ugagcuggau cacuugaguu c 21
<210> 6651
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6651
ugaggacacg uggccugcac c 21
<210> 6652
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6652
ugaggauugu gucacggugg a 21
<210> 6653
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6653
ugaggcaccu gugucuggcc a 21
<210> 6654
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6654
ugaggcaggg ccaggggguc c 21
<210> 6655
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6655
ugaggcuguc gugagcuaug a 21
<210> 6656
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6656
ugagucacug gucacccuua a 21
<210> 6657
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6657
ugaguggcuu cugggagaug g 21
<210> 6658
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6658
ugaguucagg aguuggagac c 21
<210> 6659
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6659
ugaguuuagg gguuuggcuu a 21
<210> 6660
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6660
ugaguuucuc uccaccguga c 21
<210> 6661
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6661
ugaguuuggu cucggugcca c 21
<210> 6662
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6662
ugauaagccu uucugguuuc g 21
<210> 6663
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6663
ugaucacagu aagacauuca g 21
<210> 6664
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6664
ugauccagcu cagccuccca a 21
<210> 6665
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6665
ugaucgugaa uaucgagaac u 21
<210> 6666
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6666
ugaucuggcu gaauccgugg u 21
<210> 6667
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6667
ugaugccacu ucccagaggc a 21
<210> 6668
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6668
ugauggguau guguuuaaaa c 21
<210> 6669
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6669
ugaugucccc guuguaugua u 21
<210> 6670
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6670
ugauguccgg agagacagug a 21
<210> 6671
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6671
ugauuaugcc acugcuuucc a 21
<210> 6672
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6672
ugauucgggg gugacagggc a 21
<210> 6673
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6673
ugcaaacaua acaaaaaauc c 21
<210> 6674
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6674
ugcaaacccu gguugcugua u 21
<210> 6675
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6675
ugcaaaugcc uccaagccau u 21
<210> 6676
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6676
ugcaacagua acacggcgau u 21
<210> 6677
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6677
ugcaacgcuu uuugggagaa u 21
<210> 6678
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6678
ugcaagccuu gcuagacagc c 21
<210> 6679
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6679
ugcaaggaga ccacgggaau g 21
<210> 6680
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6680
ugcaauggcu uggguuggga u 21
<210> 6681
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6681
ugcacacagu ccaguucgug c 21
<210> 6682
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6682
ugcacccagg uguggcuguc a 21
<210> 6683
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6683
ugcacgaacu ggacugugug c 21
<210> 6684
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6684
ugcacgguga ggccgggcgc a 21
<210> 6685
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6685
ugcacugaug uccggagaga c 21
<210> 6686
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6686
ugcacuguuu ucugucgugu g 21
<210> 6687
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6687
ugcacuuucu caguucagag u 21
<210> 6688
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6688
ugcacuuugu auauugguug a 21
<210> 6689
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6689
ugcaggccac guguccucac g 21
<210> 6690
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6690
ugcagggaac cgugauaagc c 21
<210> 6691
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6691
ugcauagaag agguaaacac g 21
<210> 6692
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6692
ugcauagaag uggaagcacu a 21
<210> 6693
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6693
ugcaucagca gcccauggcc u 21
<210> 6694
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6694
ugcaugggca cuguccgaag c 21
<210> 6695
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6695
ugcauggugc aucagcagcc c 21
<210> 6696
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6696
ugcauguuuu aaacacauac c 21
<210> 6697
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6697
ugccaaaugu acacagugua c 21
<210> 6698
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6698
ugccaauccc uugugacauc u 21
<210> 6699
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6699
ugccaccacg gauucagcca g 21
<210> 6700
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6700
ugccaccgua cccagcugau u 21
<210> 6701
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6701
ugccacuucc cagaggcaga g 21
<210> 6702
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6702
ugccaucugc uguugugugu u 21
<210> 6703
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6703
ugccauuguc gucuuuaugu c 21
<210> 6704
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6704
ugcccagaac ccuuccugag a 21
<210> 6705
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6705
ugcccaggcu ggaaagcagu g 21
<210> 6706
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6706
ugcccauccu cccgaccccu a 21
<210> 6707
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6707
ugcccaugca auggcuuggg u 21
<210> 6708
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6708
ugccccucuc uguccccggc a 21
<210> 6709
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6709
ugcccuguca cccccgaauc a 21
<210> 6710
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6710
ugccggggac agagaggggc a 21
<210> 6711
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6711
ugccucaucc accaaucucu a 21
<210> 6712
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6712
ugccuccaag ccauucacuu c 21
<210> 6713
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6713
ugccucugaa augccucuuc u 21
<210> 6714
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6714
ugccucuggg aaguggcauc a 21
<210> 6715
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6715
ugccugagac acccgguuac c 21
<210> 6716
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6716
ugccugagcu caaaccaucc u 21
<210> 6717
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6717
ugccugccag agcuuuguuu u 21
<210> 6718
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6718
ugccuggagu cccgucccug c 21
<210> 6719
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6719
ugccuggcca gaggccaugg g 21
<210> 6720
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6720
ugcgcccggc cucaccgugc a 21
<210> 6721
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6721
ugcgucccug uacagauagu g 21
<210> 6722
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6722
ugcuagacag ccagguuagc c 21
<210> 6723
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6723
ugcucaggcc uggucuccaa c 21
<210> 6724
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6724
ugcuccgaaa ccagaaaggc u 21
<210> 6725
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6725
ugcuguauuu guucagugac u 21
<210> 6726
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6726
ugcuguugug uguugaaagc c 21
<210> 6727
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6727
ugcuuccacu ucuaugcaaa u 21
<210> 6728
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6728
ugcuucucug ggccugacau c 21
<210> 6729
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6729
ugcuuuccag ccugggcaac a 21
<210> 6730
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6730
ugcuuugguc uucucugucu u 21
<210> 6731
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6731
uggaaagcag uggcauaauc a 21
<210> 6732
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6732
uggaagauga aaggggaggg g 21
<210> 6733
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6733
uggaagcacu aggugggcgg a 21
<210> 6734
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6734
uggaaguggg uaggggucgg g 21
<210> 6735
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6735
uggacugugu gcaacgcuuu u 21
<210> 6736
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6736
uggagaccag gccugagcaa c 21
<210> 6737
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6737
uggagagaaa cucaaaacuu c 21
<210> 6738
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6738
uggagagaaa uggagguguc a 21
<210> 6739
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6739
uggaggauga cguggcguga a 21
<210> 6740
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6740
uggaggcauu ugcauagaag u 21
<210> 6741
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6741
uggagguguc auccuggucc c 21
<210> 6742
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6742
uggagguugc agugagccau g 21
<210> 6743
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6743
uggagucccg ucccugccca g 21
<210> 6744
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6744
uggaucguuu gacgggacuu c 21
<210> 6745
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6745
uggaugaggc agggccaggg g 21
<210> 6746
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6746
uggcaauugu ccccagggac a 21
<210> 6747
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6747
uggcaccaac gggacccccu g 21
<210> 6748
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6748
uggcaccgag accaaacuca u 21
<210> 6749
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6749
uggcaggcaa ugcuuugguc u 21
<210> 6750
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6750
uggcaguucu cgauauucac g 21
<210> 6751
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6751
uggcaucauu uggugaauga g 21
<210> 6752
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6752
uggcauuugu guuauuauuu u 21
<210> 6753
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6753
uggccaaauu cauuuuuuaa g 21
<210> 6754
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6754
uggccagaca caggugccuc a 21
<210> 6755
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6755
uggccagagg ccaugggcug c 21
<210> 6756
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6756
uggccaggca uggcgaggcu g 21
<210> 6757
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6757
uggcccugcc ucauccacca a 21
<210> 6758
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6758
uggccgugag gacacguggc c 21
<210> 6759
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6759
uggccucugg ccaggcaugg c 21
<210> 6760
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6760
uggccugcac ccaggugugg c 21
<210> 6761
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6761
uggccuggga ucccauccca a 21
<210> 6762
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6762
uggcgaggcu gaggugggag g 21
<210> 6763
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6763
uggcgucgga aaugaucugg c 21
<210> 6764
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6764
uggcgugaac aucugccugg a 21
<210> 6765
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6765
uggcugaauc cgugguggca c 21
<210> 6766
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6766
uggcugucag gacaccagcc u 21
<210> 6767
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6767
uggcugucua gcaaggcuug c 21
<210> 6768
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6768
uggcuuaagg aagguacaaa c 21
<210> 6769
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6769
uggcuuagag auugguggau g 21
<210> 6770
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6770
uggcuucugg gagaugggug u 21
<210> 6771
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6771
uggcuuggag gcauuugcau a 21
<210> 6772
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6772
uggcuugggu ugggauuuug g 21
<210> 6773
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6773
uggcuuucaa cacacaacag c 21
<210> 6774
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6774
ugggaagugg caucauuugg u 21
<210> 6775
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6775
ugggagaaug auguccccgu u 21
<210> 6776
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6776
ugggagaugg gugucacuuu u 21
<210> 6777
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6777
ugggaggaug guuugagcuc a 21
<210> 6778
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6778
ugggaggcag aacaggcuuc g 21
<210> 6779
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6779
ugggaggcug agcuggauca c 21
<210> 6780
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6780
ugggauccca ggccagggaa a 21
<210> 6781
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6781
ugggauccca ucccaacaca c 21
<210> 6782
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6782
ugggaucucg cuuuguugcu c 21
<210> 6783
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6783
ugggauggga ucccaggcca g 21
<210> 6784
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6784
ugggauuuug guuucuuccu u 21
<210> 6785
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6785
ugggcaccag gcuggugucc u 21
<210> 6786
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6786
ugggcacugu ccgaagccug u 21
<210> 6787
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6787
ugggcaggga cgggacucca g 21
<210> 6788
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6788
ugggccugac auccccuccc c 21
<210> 6789
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6789
ugggcggaca uaaagacgac a 21
<210> 6790
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6790
ugggcugcug augcaccaug c 21
<210> 6791
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6791
uggggaagug aauggcuugg a 21
<210> 6792
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6792
uggggacaau ugccaauccc u 21
<210> 6793
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6793
uggggauuuu uuguuauguu u 21
<210> 6794
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6794
uggguacggu ggcacgugcc u 21
<210> 6795
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6795
uggguagggg ucgggaggau g 21
<210> 6796
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6796
uggguaugug uuuaaaacau g 21
<210> 6797
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6797
ugggucauga uucgggggug a 21
<210> 6798
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6798
ugggugcagg ccacgugucc u 21
<210> 6799
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6799
uggguggguc augauucggg g 21
<210> 6800
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6800
ugggugucac uuuuuaaacc a 21
<210> 6801
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6801
uggguuggga uuuugguuuc u 21
<210> 6802
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6802
uggguuugua ccuuccuuaa g 21
<210> 6803
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6803
uggucacccu uaauauuuau u 21
<210> 6804
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6804
uggucagucu ggaggaugac g 21
<210> 6805
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6805
uggucccccc gggccuguuu c 21
<210> 6806
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6806
uggucuccuu gcacuuucuc a 21
<210> 6807
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6807
uggucucggu gccaccacgg a 21
<210> 6808
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6808
uggucuucuc ugucuuugaa u 21
<210> 6809
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6809
uggugaauga guuuggucuc g 21
<210> 6810
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6810
uggugcauca gcagcccaug g 21
<210> 6811
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6811
uggugccauc ugcuguugug u 21
<210> 6812
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6812
uggugcccau ccucccgacc c 21
<210> 6813
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6813
ugguggauga ggcagggcca g 21
<210> 6814
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6814
ugguggcacc gagaccaaac u 21
<210> 6815
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6815
ugguguccug acagccacac c 21
<210> 6816
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6816
ugguugcugu auuuguucag u 21
<210> 6817
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6817
ugguuuaaaa agugacaccc a 21
<210> 6818
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6818
ugguuucgga gcacguaaau g 21
<210> 6819
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6819
ugguuucuuc cuuuccucgu g 21
<210> 6820
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6820
ugguuugagc ucaggcauuu g 21
<210> 6821
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6821
ugguuuuugu agagauggga u 21
<210> 6822
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6822
uguacaaaga uuauuugcac g 21
<210> 6823
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6823
uguacaacuc ugaacugaga a 21
<210> 6824
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6824
uguacacagu guacaacucu g 21
<210> 6825
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6825
uguacacugu guacauuugg c 21
<210> 6826
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6826
uguacagaua guggggauuu u 21
<210> 6827
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6827
uguacaggga cgcauuuacg u 21
<210> 6828
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6828
uguacauaaa gaagaggcau u 21
<210> 6829
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6829
uguaccuucc uuaagccagg a 21
<210> 6830
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6830
uguagccuga augucuuacu g 21
<210> 6831
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6831
uguagggggu uauugccucu g 21
<210> 6832
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6832
uguauagaag guuuuuguag c 21
<210> 6833
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6833
uguaugagug gcuucuggga g 21
<210> 6834
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6834
uguauguaug aguggcuucu g 21
<210> 6835
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6835
uguauuucug aaauaggguc u 21
<210> 6836
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6836
uguauuuguu cagugacuau u 21
<210> 6837
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6837
ugucaaugaa ugccggggac a 21
<210> 6838
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6838
ugucacaagg gauuggcaau u 21
<210> 6839
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6839
ugucaccccc gaaucaugac c 21
<210> 6840
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6840
ugucacggug gagagaaacu c 21
<210> 6841
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6841
ugucacuguc ucuccggaca u 21
<210> 6842
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6842
ugucaggaca ccagccuggu g 21
<210> 6843
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6843
ugucaggccc agagaagcaa g 21
<210> 6844
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6844
ugucauccug guccccccgg g 21
<210> 6845
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6845
uguccccagg gacaaaacac u 21
<210> 6846
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6846
uguccccggc auucauugac a 21
<210> 6847
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6847
uguccccguu guauguauga g 21
<210> 6848
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6848
ugucccuggg gacaauugcc a 21
<210> 6849
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6849
uguccgaagc cuguucugcc u 21
<210> 6850
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6850
uguccgccca ccuagugcuu c 21
<210> 6851
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6851
uguccggaga gacagugaca g 21
<210> 6852
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6852
uguccucacg gccaagguaa c 21
<210> 6853
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6853
uguccugaca gccacaccug g 21
<210> 6854
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6854
ugucgucuuu auguccgccc a 21
<210> 6855
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6855
ugucgugagc uaugauuaug c 21
<210> 6856
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6856
ugucgugugu guugggaugg g 21
<210> 6857
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6857
ugucguugau ggguaugugu u 21
<210> 6858
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6858
ugucuagcaa ggcuugcaua g 21
<210> 6859
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6859
ugucucuccg gacaucagug c 21
<210> 6860
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6860
ugucuggcca aauucauuuu u 21
<210> 6861
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6861
ugucuuucga gguggguuug u 21
<210> 6862
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6862
ugucuuugaa uaaaacaagg c 21
<210> 6863
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6863
ugugacaucu ucacgcggga g 21
<210> 6864
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6864
ugugcaacgc uuuuugggag a 21
<210> 6865
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6865
uguggcuguc aggacaccag c 21
<210> 6866
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6866
uguguagggg guuauugccu c 21
<210> 6867
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6867
ugugucacgg uggagagaaa c 21
<210> 6868
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6868
ugugucuggc caaauucauu u 21
<210> 6869
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6869
ugugugcaac gcuuuuuggg a 21
<210> 6870
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6870
uguguguuga aagccacuug c 21
<210> 6871
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6871
uguguguugg gaugggaucc c 21
<210> 6872
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6872
uguguugaaa gccacuugcu u 21
<210> 6873
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6873
uguguuggga ugggauccca g 21
<210> 6874
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6874
uguguuuaaa acaugcacgg u 21
<210> 6875
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6875
uguuacuguu gcacugaugu c 21
<210> 6876
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6876
uguucacgcc acgucauccu c 21
<210> 6877
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6877
uguucaguga cuauucucgg g 21
<210> 6878
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6878
uguucugccu cccagaugaa u 21
<210> 6879
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6879
uguugaaagc cacuugcuuc u 21
<210> 6880
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6880
uguugcacug auguccggag a 21
<210> 6881
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6881
uguugcucag gccuggucuc c 21
<210> 6882
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6882
uguugggaug ggaucccagg c 21
<210> 6883
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6883
uguugugugu ugaaagccac u 21
<210> 6884
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6884
uguuuaaaac augcacggug a 21
<210> 6885
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6885
uguuuaccuc uucuaugcaa g 21
<210> 6886
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6886
uguuucucuu auccuucacg a 21
<210> 6887
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6887
uguuugagga uugugucacg g 21
<210> 6888
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6888
uguuuuaaac acauacccau c 21
<210> 6889
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6889
uguuuuauuc aaagacagag a 21
<210> 6890
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6890
uguuuucugu cguguguguu g 21
<210> 6891
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6891
uguuuugucc cuggggacaa u 21
<210> 6892
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6892
uuaaaaaaug aauuuggcca g 21
<210> 6893
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6893
uuaaaaagug acacccaucu c 21
<210> 6894
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6894
uuaaaaauca gcuggguacg g 21
<210> 6895
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6895
uuaaaacaug cacggugagg c 21
<210> 6896
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6896
uuaaacacau acccaucaac g 21
<210> 6897
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6897
uuaagccagg aaagggauuc a 21
<210> 6898
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6898
uuaaggaagg uacaaaccca c 21
<210> 6899
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6899
uuaaggguga ccagugacuc a 21
<210> 6900
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6900
uuaagugccu gagacacccg g 21
<210> 6901
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6901
uuaauugauc acaguaagac a 21
<210> 6902
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6902
uuacaggcgu gaggcaccug u 21
<210> 6903
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6903
uuaccucuuc uaugcaagcc u 21
<210> 6904
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6904
uuaccuuggc cgugaggaca c 21
<210> 6905
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6905
uuacgugcuc cgaaaccaga a 21
<210> 6906
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6906
uuacuauguu gcccaggcug g 21
<210> 6907
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6907
uuacuguugc acugaugucc g 21
<210> 6908
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6908
uuagagauug guggaugagg c 21
<210> 6909
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6909
uuagccuuug cccugucacc c 21
<210> 6910
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6910
uuagggguuu ggcuuagaga u 21
<210> 6911
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6911
uuauauauuu auucaucugg g 21
<210> 6912
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6912
uuauccuuca cgaggaaagg a 21
<210> 6913
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6913
uuaugccacu gcuuuccagc c 21
<210> 6914
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6914
uuauguccgc ccaccuagug c 21
<210> 6915
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6915
uuauuaagug ccugagacac c 21
<210> 6916
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6916
uuauucaaag acagagaaga c 21
<210> 6917
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6917
uuauucaucu gggaggcaga a 21
<210> 6918
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6918
uuauugccuc ugaaaugccu c 21
<210> 6919
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6919
uuauuugcac gaacuggacu g 21
<210> 6920
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6920
uuauuuugca cuguuuucug u 21
<210> 6921
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6921
uuauuuuugc aaacccuggu u 21
<210> 6922
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6922
uucaaagaca gagaagacca a 21
<210> 6923
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6923
uucaaagccg ugaucgugaa u 21
<210> 6924
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6924
uucaacacac aacagcagau g 21
<210> 6925
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6925
uucaccaaau gaugccacuu c 21
<210> 6926
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6926
uucacgagga aaggaagaaa c 21
<210> 6927
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6927
uucacgauca cggcuuugaa g 21
<210> 6928
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6928
uucacgccac gucauccucc a 21
<210> 6929
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6929
uucacgcggg agucugacgg a 21
<210> 6930
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6930
uucacuuccc caaucuuguc g 21
<210> 6931
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6931
uucagaaaga accugaaguc c 21
<210> 6932
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6932
uucagaggca auaacccccu a 21
<210> 6933
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6933
uucagaguug uacacugugu a 21
<210> 6934
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6934
uucagccaga ucauuuccga c 21
<210> 6935
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6935
uucaggaguu ggagaccagg c 21
<210> 6936
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6936
uucagguucu uucugaaauc g 21
<210> 6937
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6937
uucagugacu auucucgggg c 21
<210> 6938
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6938
uucaucuggg aggcagaaca g 21
<210> 6939
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6939
uucaucuucc auguuugagg a 21
<210> 6940
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6940
uucauggcgu cggaaaugau c 21
<210> 6941
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6941
uucauugaca cgggcuuucc c 21
<210> 6942
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6942
uucauuuuuu aagagauggg g 21
<210> 6943
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6943
uuccacuucu augcaaaugc c 21
<210> 6944
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6944
uuccauguuu gaggauugug u 21
<210> 6945
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6945
uuccauuccc guggucuccu u 21
<210> 6946
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6946
uucccagagg cagagccuga g 21
<210> 6947
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6947
uuccccaauc uugucguuga u 21
<210> 6948
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6948
uucccguggu cuccuugcac u 21
<210> 6949
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6949
uucccuggcc ugggauccca u 21
<210> 6950
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6950
uuccgacgcc augaaucccu u 21
<210> 6951
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6951
uuccucguga aggauaagag a 21
<210> 6952
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6952
uuccugagac cucgccggcc u 21
<210> 6953
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6953
uuccuggaga gaaauggagg u 21
<210> 6954
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6954
uuccuggcuu aaggaaggua c 21
<210> 6955
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6955
uuccuuaagc caggaaaggg a 21
<210> 6956
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6956
uuccuuuccu cgugaaggau a 21
<210> 6957
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6957
uucgaggugg guuuguaccu u 21
<210> 6958
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6958
uucggacagu gcccaugcaa u 21
<210> 6959
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6959
uucggagcac guaaaugcgu c 21
<210> 6960
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6960
uucgggggug acagggcaaa g 21
<210> 6961
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6961
uucuaugcaa augccuccaa g 21
<210> 6962
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6962
uucuaugcaa gccuugcuag a 21
<210> 6963
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6963
uucucaguuc agaguuguac a 21
<210> 6964
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6964
uucucccaaa aagcguugca c 21
<210> 6965
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6965
uucucgauau ucacgaucac g 21
<210> 6966
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6966
uucucggggc ccuguguagg g 21
<210> 6967
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6967
uucucuccac cgugacacaa u 21
<210> 6968
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6968
uucucuccag gaaguuuuga g 21
<210> 6969
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6969
uucucugggc cugacauccc c 21
<210> 6970
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6970
uucucugucu uugaauaaaa c 21
<210> 6971
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6971
uucucuuauc cuucacgagg a 21
<210> 6972
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6972
uucugaaaua gggucuucau c 21
<210> 6973
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6973
uucugaaauc gccguguuac u 21
<210> 6974
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6974
uucugccucc cagaugaaua a 21
<210> 6975
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6975
uucugggaga ugggugucac u 21
<210> 6976
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6976
uucugggcag ggacgggacu c 21
<210> 6977
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6977
uucugguuuc ggagcacgua a 21
<210> 6978
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6978
uucugucgug uguguuggga u 21
<210> 6979
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6979
uucuuccuuu ccucgugaag g 21
<210> 6980
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6980
uucuuucuga aaucgccgug u 21
<210> 6981
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6981
uugaaagcca cuugcuucuc u 21
<210> 6982
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6982
uugaaguccc ggucaaccug c 21
<210> 6983
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6983
uugaauaaaa caaggccggc g 21
<210> 6984
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6984
uugacacggg cuuucccugg c 21
<210> 6985
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6985
uugaccggga cuucaaagcc g 21
<210> 6986
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6986
uugacgggac uucagguucu u 21
<210> 6987
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6987
uugacuccug aguuuagggg u 21
<210> 6988
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6988
uugagcucag gcauuugagg c 21
<210> 6989
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6989
uugaggauug ugucacggug g 21
<210> 6990
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6990
uugaggcugu cgugagcuau g 21
<210> 6991
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6991
uugaguucag gaguuggaga c 21
<210> 6992
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6992
uugaguuucu cuccaccgug a 21
<210> 6993
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6993
uugaucacag uaagacauuc a 21
<210> 6994
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6994
uugaugggua uguguuuaaa a 21
<210> 6995
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6995
uugcaaaccc ugguugcugu a 21
<210> 6996
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6996
uugcacacag uccaguucgu g 21
<210> 6997
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6997
uugcacgaac uggacugugu g 21
<210> 6998
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6998
uugcacugau guccggagag a 21
<210> 6999
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 6999
uugcacuguu uucugucgug u 21
<210> 7000
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7000
uugcacuuuc ucaguucaga g 21
<210> 7001
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7001
uugcacuuug uauauugguu g 21
<210> 7002
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7002
uugcauagaa gagguaaaca c 21
<210> 7003
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7003
uugcauagaa guggaagcac u 21
<210> 7004
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7004
uugcaugggc acuguccgaa g 21
<210> 7005
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7005
uugccaaucc cuugugacau c 21
<210> 7006
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7006
uugcccaggc uggaaagcag u 21
<210> 7007
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7007
uugcccuguc acccccgaau c 21
<210> 7008
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7008
uugccucuga aaugccucuu c 21
<210> 7009
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7009
uugccugcca gagcuuuguu u 21
<210> 7010
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7010
uugcuagaca gccagguuag c 21
<210> 7011
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7011
uugcucaggc cuggucucca a 21
<210> 7012
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7012
uugcuguauu uguucaguga c 21
<210> 7013
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7013
uugcuucucu gggccugaca u 21
<210> 7014
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7014
uuggagacca ggccugagca a 21
<210> 7015
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7015
uuggaggcau uugcauagaa g 21
<210> 7016
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7016
uuggcaauug uccccaggga c 21
<210> 7017
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7017
uuggccagac acaggugccu c 21
<210> 7018
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7018
uuggccguga ggacacgugg c 21
<210> 7019
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7019
uuggcuuaga gauuggugga u 21
<210> 7020
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7020
uugggagaau gauguccccg u 21
<210> 7021
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7021
uugggaggcu gagcuggauc a 21
<210> 7022
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7022
uugggauggg aucccaggcc a 21
<210> 7023
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7023
uugggauuuu gguuucuucc u 21
<210> 7024
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7024
uuggggaagu gaauggcuug g 21
<210> 7025
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7025
uuggguuggg auuuugguuu c 21
<210> 7026
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7026
uuggucucgg ugccaccacg g 21
<210> 7027
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7027
uuggucuucu cugucuuuga a 21
<210> 7028
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7028
uuggugaaug aguuuggucu c 21
<210> 7029
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7029
uuggugccau cugcuguugu g 21
<210> 7030
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7030
uugguggaug aggcagggcc a 21
<210> 7031
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7031
uugguuucuu ccuuuccucg u 21
<210> 7032
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7032
uugguuuuug uagagauggg a 21
<210> 7033
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7033
uuguacacug uguacauuug g 21
<210> 7034
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7034
uuguacauaa agaagaggca u 21
<210> 7035
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7035
uuguaccuuc cuuaagccag g 21
<210> 7036
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7036
uuguagccug aaugucuuac u 21
<210> 7037
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7037
uuguauguau gaguggcuuc u 21
<210> 7038
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7038
uuguauuucu gaaauagggu c 21
<210> 7039
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7039
uuguccccag ggacaaaaca c 21
<210> 7040
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7040
uugucccugg ggacaauugc c 21
<210> 7041
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7041
uugucgucuu uauguccgcc c 21
<210> 7042
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7042
uugucguuga uggguaugug u 21
<210> 7043
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7043
uugugacauc uucacgcggg a 21
<210> 7044
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7044
uugugucacg guggagagaa a 21
<210> 7045
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7045
uuguguguug aaagccacuu g 21
<210> 7046
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7046
uuguucagug acuauucucg g 21
<210> 7047
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7047
uuguugcuca ggccuggucu c 21
<210> 7048
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7048
uuguuuuauu caaagacaga g 21
<210> 7049
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7049
uuuaaaaagu gacacccauc u 21
<210> 7050
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7050
uuuaaaacau gcacggugag g 21
<210> 7051
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7051
uuuaaacaca uacccaucaa c 21
<210> 7052
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7052
uuuaccucuu cuaugcaagc c 21
<210> 7053
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7053
uuuacgugcu ccgaaaccag a 21
<210> 7054
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7054
uuuagggguu uggcuuagag a 21
<210> 7055
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7055
uuuauguccg cccaccuagu g 21
<210> 7056
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7056
uuuauuaagu gccugagaca c 21
<210> 7057
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7057
uuuauucaaa gacagagaag a 21
<210> 7058
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7058
uuuauucauc ugggaggcag a 21
<210> 7059
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7059
uuuauuuuug caaacccugg u 21
<210> 7060
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7060
uuucaacaca caacagcaga u 21
<210> 7061
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7061
uuucagaaag aaccugaagu c 21
<210> 7062
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7062
uuucagaggc aauaaccccc u 21
<210> 7063
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7063
uuucaucuuc cauguuugag g 21
<210> 7064
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7064
uuucccuggc cugggauccc a 21
<210> 7065
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7065
uuuccgacgc caugaauccc u 21
<210> 7066
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7066
uuuccucgug aaggauaaga g 21
<210> 7067
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7067
uuuccuggcu uaaggaaggu a 21
<210> 7068
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7068
uuucgaggug gguuuguacc u 21
<210> 7069
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7069
uuucggagca cguaaaugcg u 21
<210> 7070
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7070
uuucucaguu cagaguugua c 21
<210> 7071
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7071
uuucucucca ccgugacaca a 21
<210> 7072
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7072
uuucucucca ggaaguuuug a 21
<210> 7073
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7073
uuucucuuau ccuucacgag g 21
<210> 7074
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7074
uuucugaaau agggucuuca u 21
<210> 7075
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7075
uuucugaaau cgccguguua c 21
<210> 7076
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7076
uuucugguuu cggagcacgu a 21
<210> 7077
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7077
uuucugucgu guguguuggg a 21
<210> 7078
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7078
uuucuuccuu uccucgugaa g 21
<210> 7079
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7079
uuugaagucc cggucaaccu g 21
<210> 7080
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7080
uuugaauaaa acaaggccgg c 21
<210> 7081
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7081
uuugacggga cuucagguuc u 21
<210> 7082
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7082
uuugagcuca ggcauuugag g 21
<210> 7083
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7083
uuugaggauu gugucacggu g 21
<210> 7084
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7084
uuugaggcug ucgugagcua u 21
<210> 7085
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7085
uuugaguuuc ucuccaccgu g 21
<210> 7086
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7086
uuugcaaacc cugguugcug u 21
<210> 7087
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7087
uuugcacgaa cuggacugug u 21
<210> 7088
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7088
uuugcacugu uuucugucgu g 21
<210> 7089
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7089
uuugcauaga aguggaagca c 21
<210> 7090
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7090
uuugcccugu cacccccgaa u 21
<210> 7091
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7091
uuuggccaga cacaggugcc u 21
<210> 7092
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7092
uuuggcuuag agauuggugg a 21
<210> 7093
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7093
uuugggagaa ugaugucccc g 21
<210> 7094
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7094
uuugggaggc ugagcuggau c 21
<210> 7095
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7095
uuuggucucg gugccaccac g 21
<210> 7096
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7096
uuuggugaau gaguuugguc u 21
<210> 7097
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7097
uuugguuucu uccuuuccuc g 21
<210> 7098
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7098
uuugguuuuu guagagaugg g 21
<210> 7099
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7099
uuuguacaua aagaagaggc a 21
<210> 7100
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7100
uuuguaccuu ccuuaagcca g 21
<210> 7101
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7101
uuuguagccu gaaugucuua c 21
<210> 7102
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7102
uuugucccug gggacaauug c 21
<210> 7103
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7103
uuuguucagu gacuauucuc g 21
<210> 7104
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7104
uuuguugcuc aggccugguc u 21
<210> 7105
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7105
uuuuaaacac auacccauca a 21
<210> 7106
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7106
uuuucugucg uguguguugg g 21
<210> 7107
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7107
uuuugaguuu cucuccaccg u 21
<210> 7108
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7108
uuuugcaaac ccugguugcu g 21
<210> 7109
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7109
uuuugcacug uuuucugucg u 21
<210> 7110
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7110
uuuugggaga augauguccc c 21
<210> 7111
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7111
uuuugguuuc uuccuuuccu c 21
<210> 7112
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7112
uuuugguuuu uguagagaug g 21
<210> 7113
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7113
uuuuguagcc ugaaugucuu a 21
<210> 7114
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7114
uuuugucccu ggggacaauu g 21
<210> 7115
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7115
uuuuugcaaa cccugguugc u 21
<210> 7116
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7116
uuuuugggag aaugaugucc c 21
<210> 7117
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7117
uuuuugguuu uuguagagau g 21
<210> 7118
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7118
uuuuuguagc cugaaugucu u 21
<210> 7119
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7119
aaaaaaccau gcauggugca uc 22
<210> 7120
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7120
aaaaaauccc cacuaucugu ac 22
<210> 7121
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7121
aaaaaaugaa uuuggccaga ca 22
<210> 7122
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7122
aaaaaccaug cauggugcau ca 22
<210> 7123
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7123
aaaaagcguu gcacacaguc ca 22
<210> 7124
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7124
aaaaagugac acccaucucc ca 22
<210> 7125
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7125
aaaaaguuaa aaaucagcug gg 22
<210> 7126
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7126
aaaaaucagc uggguacggu gg 22
<210> 7127
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7127
aaaaaucccc acuaucugua ca 22
<210> 7128
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7128
aaaaaugaau uuggccagac ac 22
<210> 7129
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7129
aaaacaaagc ucuggcaggc aa 22
<210> 7130
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7130
aaaacaaggc cggcgagguc uc 22
<210> 7131
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7131
aaaacaugca cggugaggcc gg 22
<210> 7132
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7132
aaaaccaaaa aguuaaaaau ca 22
<210> 7133
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7133
aaaaccaugc auggugcauc ag 22
<210> 7134
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7134
aaaacuuccu ggagagaaau gg 22
<210> 7135
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7135
aaaagcguug cacacagucc ag 22
<210> 7136
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7136
aaaagugaca cccaucuccc ag 22
<210> 7137
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7137
aaaaguuaaa aaucagcugg gu 22
<210> 7138
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7138
aaaauaaaua aauccuccag uc 22
<210> 7139
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7139
aaaaucagcu ggguacggug gc 22
<210> 7140
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7140
aaaaucccaa cccaagccau ug 22
<210> 7141
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7141
aaaaucccca cuaucuguac ag 22
<210> 7142
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7142
aaaaugaauu uggccagaca ca 22
<210> 7143
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7143
aaacaaagcu cuggcaggca au 22
<210> 7144
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7144
aaacaaggcc ggcgaggucu ca 22
<210> 7145
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7145
aaacacauac ccaucaacga ca 22
<210> 7146
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7146
aaacacguug acuccugagu uu 22
<210> 7147
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7147
aaacaggccc ggggggacca gg 22
<210> 7148
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7148
aaacauaaca aaaaaucccc ac 22
<210> 7149
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7149
aaacaugcac ggugaggccg gg 22
<210> 7150
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7150
aaacauggaa gaugaaaggg ga 22
<210> 7151
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7151
aaaccaaaaa guuaaaaauc ag 22
<210> 7152
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7152
aaaccaaaau cccaacccaa gc 22
<210> 7153
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7153
aaaccacugu auagaagguu uu 22
<210> 7154
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7154
aaaccagaaa ggcuuaucac gg 22
<210> 7155
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7155
aaaccauccu cccaccucag cc 22
<210> 7156
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7156
aaaccaugca uggugcauca gc 22
<210> 7157
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7157
aaacccaccu cgaaagacac ug 22
<210> 7158
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7158
aaaccccuaa acucaggagu ca 22
<210> 7159
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7159
aaacccuggu ugcuguauuu gu 22
<210> 7160
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7160
aaacgaucca gacuggagga uu 22
<210> 7161
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7161
aaacucaaaa cuuccuggag ag 22
<210> 7162
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7162
aaacucagga gucaacgugu uu 22
<210> 7163
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7163
aaacucauuc accaaaugau gc 22
<210> 7164
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7164
aaacuuccug gagagaaaug ga 22
<210> 7165
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7165
aaagaaccug aagucccguc aa 22
<210> 7166
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7166
aaagaagagg cauuucagag gc 22
<210> 7167
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7167
aaagacacug ggugggucau ga 22
<210> 7168
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7168
aaagacagag aagaccaaag ca 22
<210> 7169
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7169
aaagacgaca auggcaguuc uc 22
<210> 7170
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7170
aaagauuauu ugcacgaacu gg 22
<210> 7171
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7171
aaagcagugg cauaaucaua gc 22
<210> 7172
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7172
aaagcauugc cugccagagc uu 22
<210> 7173
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7173
aaagccacuu gcuucucugg gc 22
<210> 7174
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7174
aaagcccgug ucaaugaaug cc 22
<210> 7175
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7175
aaagccguga ucgugaauau cg 22
<210> 7176
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7176
aaagcgagau cccaucucua ca 22
<210> 7177
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7177
aaagcguugc acacagucca gu 22
<210> 7178
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7178
aaagcucugg caggcaaugc uu 22
<210> 7179
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7179
aaaggaagaa accaaaaucc ca 22
<210> 7180
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7180
aaaggcuaac cuggcugucu ag 22
<210> 7181
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7181
aaaggcuuau cacgguuccc ug 22
<210> 7182
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7182
aaagggauuc auggcgucgg aa 22
<210> 7183
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7183
aaaggggagg ggaugucagg cc 22
<210> 7184
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7184
aaagugacac ccaucuccca ga 22
<210> 7185
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7185
aaagugcaaa cauaacaaaa aa 22
<210> 7186
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7186
aaagugcaag gagaccacgg ga 22
<210> 7187
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7187
aaaguuaaaa aucagcuggg ua 22
<210> 7188
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7188
aaauaaauaa auccuccagu cu 22
<210> 7189
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7189
aaauaaaucc uccagucugg au 22
<210> 7190
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7190
aaauacagca accaggguuu gc 22
<210> 7191
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7191
aaauauauaa aacaaagcuc ug 22
<210> 7192
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7192
aaauauuaag ggugaccagu ga 22
<210> 7193
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7193
aaaucagcug gguacggugg ca 22
<210> 7194
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7194
aaaucccaac ccaagccauu gc 22
<210> 7195
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7195
aaauccccac uaucuguaca gg 22
<210> 7196
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7196
aaauccucca gucuggaucg uu 22
<210> 7197
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7197
aaaucgccgu guuacuguug ca 22
<210> 7198
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7198
aaaugaauuu ggccagacac ag 22
<210> 7199
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7199
aaaugaucug gcugaauccg ug 22
<210> 7200
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7200
aaaugaugcc acuucccaga gg 22
<210> 7201
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7201
aaaugccaaa uguacacagu gu 22
<210> 7202
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7202
aaaugccucc aagccauuca cu 22
<210> 7203
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7203
aaaugccuga gcucaaacca uc 22
<210> 7204
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7204
aaaugcgucc cuguacagau ag 22
<210> 7205
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7205
aaauggaggu gucauccugg uc 22
<210> 7206
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7206
aaauguacac aguguacaac uc 22
<210> 7207
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7207
aacaaaaaau ccccacuauc ug 22
<210> 7208
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7208
aacaaagcuc uggcaggcaa ug 22
<210> 7209
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7209
aacaaauaca gcaaccaggg uu 22
<210> 7210
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7210
aacaaggccg gcgaggucuc ag 22
<210> 7211
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7211
aacacaaaug ccaaauguac ac 22
<210> 7212
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7212
aacacacaac agcagauggc ac 22
<210> 7213
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7213
aacacacacg acagaaaaca gu 22
<210> 7214
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7214
aacacauacc caucaacgac aa 22
<210> 7215
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7215
aacacggcga uuucagaaag aa 22
<210> 7216
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7216
aacacguuga cuccugaguu ua 22
<210> 7217
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7217
aacagaugaa gacccuauuu ca 22
<210> 7218
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7218
aacagcagau ggcaccaacg gg 22
<210> 7219
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7219
aacaggcccg gggggaccag ga 22
<210> 7220
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7220
aacaggcuuc ggacagugcc ca 22
<210> 7221
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7221
aacaguaaca cggcgauuuc ag 22
<210> 7222
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7222
aacagugcaa aauaauaaca ca 22
<210> 7223
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7223
aacaguuuca accaauauac aa 22
<210> 7224
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7224
aacauaacaa aaaaucccca cu 22
<210> 7225
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7225
aacaucugcc uggagucccg uc 22
<210> 7226
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7226
aacaugcacg gugaggccgg gc 22
<210> 7227
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7227
aacauggaag augaaagggg ag 22
<210> 7228
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7228
aaccaaaaag uuaaaaauca gc 22
<210> 7229
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7229
aaccaaaauc ccaacccaag cc 22
<210> 7230
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7230
aaccacugua uagaagguuu uu 22
<210> 7231
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7231
aaccagaaag gcuuaucacg gu 22
<210> 7232
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7232
aaccauccuc ccaccucagc cu 22
<210> 7233
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7233
aaccaugcau ggugcaucag ca 22
<210> 7234
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7234
aacccaagcc auugcauggg ca 22
<210> 7235
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7235
aacccaccuc gaaagacacu gg 22
<210> 7236
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7236
aacccccuac acagggcccc ga 22
<210> 7237
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7237
aaccccuaaa cucaggaguc aa 22
<210> 7238
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7238
aacccugguu gcuguauuug uu 22
<210> 7239
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7239
aacccuuccu gagaccucgc cg 22
<210> 7240
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7240
aaccgggugu cucaggcacu ua 22
<210> 7241
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7241
aaccgugaua agccuuucug gu 22
<210> 7242
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7242
aaccugaagu cccgucaaac ga 22
<210> 7243
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7243
aaccugcccc ucucuguccc cg 22
<210> 7244
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7244
aaccuggcug ucuagcaagg cu 22
<210> 7245
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7245
aaccuucuau acagugguuu aa 22
<210> 7246
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7246
aacgacaaga uuggggaagu ga 22
<210> 7247
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7247
aacgauccag acuggaggau uu 22
<210> 7248
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7248
aacgcuuuuu gggagaauga ug 22
<210> 7249
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7249
aacgggaccc ccuggcccug cc 22
<210> 7250
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7250
aacggggaca ucauucuccc aa 22
<210> 7251
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7251
aacguguuua ccucuucuau gc 22
<210> 7252
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7252
aacucaaaac uuccuggaga ga 22
<210> 7253
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7253
aacucaagug auccagcuca gc 22
<210> 7254
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7254
aacucaggag ucaacguguu ua 22
<210> 7255
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7255
aacucauuca ccaaaugaug cc 22
<210> 7256
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7256
aacucugaac ugagaaagug ca 22
<210> 7257
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7257
aacugagaaa gugcaaggag ac 22
<210> 7258
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7258
aacugccauu gucgucuuua ug 22
<210> 7259
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7259
aacuggacug ugugcaacgc uu 22
<210> 7260
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7260
aacuuccugg agagaaaugg ag 22
<210> 7261
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7261
aacuuuuugg uuuuuguaga ga 22
<210> 7262
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7262
aagaaaccaa aaucccaacc ca 22
<210> 7263
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7263
aagaaccuga agucccguca aa 22
<210> 7264
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7264
aagaagaggc auuucagagg ca 22
<210> 7265
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7265
aagacacugg gugggucaug au 22
<210> 7266
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7266
aagacagaga agaccaaagc au 22
<210> 7267
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7267
aagacauuca ggcuacaaaa ac 22
<210> 7268
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7268
aagaccaaag cauugccugc ca 22
<210> 7269
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7269
aagacgacaa uggcaguucu cg 22
<210> 7270
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7270
aagagaaaca ggcccggggg ga 22
<210> 7271
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7271
aagaggcauu ucagaggcaa ua 22
<210> 7272
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7272
aagagguaaa cacguugacu cc 22
<210> 7273
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7273
aagaugaaag gggaggggau gu 22
<210> 7274
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7274
aagaugucac aagggauugg ca 22
<210> 7275
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7275
aagauuauuu gcacgaacug ga 22
<210> 7276
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7276
aagauugggg aagugaaugg cu 22
<210> 7277
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7277
aagcaagugg cuuucaacac ac 22
<210> 7278
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7278
aagcacuagg ugggcggaca ua 22
<210> 7279
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7279
aagcaguggc auaaucauag cu 22
<210> 7280
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7280
aagcauugcc ugccagagcu uu 22
<210> 7281
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7281
aagccaaacc ccuaaacuca gg 22
<210> 7282
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7282
aagccacuca uacauacaac gg 22
<210> 7283
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7283
aagccacuug cuucucuggg cc 22
<210> 7284
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7284
aagccaggaa agggauucau gg 22
<210> 7285
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7285
aagccauuca cuuccccaau cu 22
<210> 7286
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7286
aagccauugc augggcacug uc 22
<210> 7287
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7287
aagcccgugu caaugaaugc cg 22
<210> 7288
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7288
aagccgugau cgugaauauc ga 22
<210> 7289
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7289
aagccuguuc ugccucccag au 22
<210> 7290
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7290
aagccuugcu agacagccag gu 22
<210> 7291
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7291
aagccuuucu gguuucggag ca 22
<210> 7292
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7292
aagcgagauc ccaucucuac aa 22
<210> 7293
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7293
aagcguugca cacaguccag uu 22
<210> 7294
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7294
aagcucuggc aggcaaugcu uu 22
<210> 7295
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7295
aaggaagaaa ccaaaauccc aa 22
<210> 7296
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7296
aaggaaggua caaacccacc uc 22
<210> 7297
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7297
aaggagacca cgggaaugga ag 22
<210> 7298
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7298
aaggauaaga gaaacaggcc cg 22
<210> 7299
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7299
aaggccggcg aggucucagg aa 22
<210> 7300
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7300
aaggcuaacc uggcugucua gc 22
<210> 7301
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7301
aaggcuuauc acgguucccu gc 22
<210> 7302
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7302
aaggcuugca uagaagaggu aa 22
<210> 7303
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7303
aagggauuca uggcgucgga aa 22
<210> 7304
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7304
aagggauugg caauuguccc ca 22
<210> 7305
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7305
aaggggaggg gaugucaggc cc 22
<210> 7306
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7306
aagggugacc agugacucag gc 22
<210> 7307
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7307
aaggguucug ggcagggacg gg 22
<210> 7308
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7308
aagguaaccg ggugucucag gc 22
<210> 7309
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7309
aagguacaaa cccaccucga aa 22
<210> 7310
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7310
aagguuuuug uagccugaau gu 22
<210> 7311
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7311
aagucccggu caaccugccc cu 22
<210> 7312
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7312
aagucccguc aaacgaucca ga 22
<210> 7313
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7313
aagugaaugg cuuggaggca uu 22
<210> 7314
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7314
aagugacacc caucucccag aa 22
<210> 7315
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7315
aagugaucca gcucagccuc cc 22
<210> 7316
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7316
aagugcaaac auaacaaaaa au 22
<210> 7317
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7317
aagugcaagg agaccacggg aa 22
<210> 7318
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7318
aagugccuga gacacccggu ua 22
<210> 7319
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7319
aaguggaagc acuagguggg cg 22
<210> 7320
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7320
aaguggcauc auuuggugaa ug 22
<210> 7321
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7321
aaguggcuuu caacacacaa ca 22
<210> 7322
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7322
aaguggguag gggucgggag ga 22
<210> 7323
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7323
aaguuaaaaa ucagcugggu ac 22
<210> 7324
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7324
aaguuuugag uuucucucca cc 22
<210> 7325
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7325
aauaaaacaa ggccggcgag gu 22
<210> 7326
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7326
aauaaauaaa uccuccaguc ug 22
<210> 7327
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7327
aauaaauauu aagggugacc ag 22
<210> 7328
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7328
aauaaauccu ccagucugga uc 22
<210> 7329
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7329
aauaacacaa augccaaaug ua 22
<210> 7330
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7330
aauaaccccc uacacagggc cc 22
<210> 7331
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7331
aauacagcaa ccaggguuug ca 22
<210> 7332
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7332
aauagucacu gaacaaauac ag 22
<210> 7333
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7333
aauauauaaa acaaagcucu gg 22
<210> 7334
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7334
aauaucgaga acugccauug uc 22
<210> 7335
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7335
aauauuaagg gugaccagug ac 22
<210> 7336
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7336
aauauuuauu aagugccuga ga 22
<210> 7337
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7337
aaucagcugg guacgguggc ac 22
<210> 7338
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7338
aaucauagcu cacgacagcc uc 22
<210> 7339
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7339
aaucaugacc cacccagugu cu 22
<210> 7340
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7340
aaucccaacc caagccauug ca 22
<210> 7341
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7341
aauccccacu aucuguacag gg 22
<210> 7342
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7342
aaucccuugu gacaucuuca cg 22
<210> 7343
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7343
aaucccuuuc cuggcuuaag ga 22
<210> 7344
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7344
aauccguggu ggcaccgaga cc 22
<210> 7345
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7345
aauccucaaa cauggaagau ga 22
<210> 7346
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7346
aauccuccag ucuggaucgu uu 22
<210> 7347
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7347
aaucgccgug uuacuguugc ac 22
<210> 7348
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7348
aaucucuaag ccaaaccccu aa 22
<210> 7349
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7349
aaucuugucg uugaugggua ug 22
<210> 7350
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7350
aaugaaugcc ggggacagag ag 22
<210> 7351
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7351
aaugaauuug gccagacaca gg 22
<210> 7352
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7352
aaugaguuug gucucggugc ca 22
<210> 7353
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7353
aaugaucugg cugaauccgu gg 22
<210> 7354
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7354
aaugaugcca cuucccagag gc 22
<210> 7355
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7355
aaugaugucc ccguuguaug ua 22
<210> 7356
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7356
aaugccaaau guacacagug ua 22
<210> 7357
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7357
aaugccgggg acagagaggg gc 22
<210> 7358
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7358
aaugccucca agccauucac uu 22
<210> 7359
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7359
aaugccugag cucaaaccau cc 22
<210> 7360
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7360
aaugcguccc uguacagaua gu 22
<210> 7361
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7361
aaugcuuugg ucuucucugu cu 22
<210> 7362
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7362
aauggaagug gguagggguc gg 22
<210> 7363
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7363
aauggaggug ucauccuggu cc 22
<210> 7364
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7364
aauggcaguu cucgauauuc ac 22
<210> 7365
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7365
aauggcuugg aggcauuugc au 22
<210> 7366
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7366
aauggcuugg guugggauuu ug 22
<210> 7367
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7367
aauguacaca guguacaacu cu 22
<210> 7368
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7368
aauugaucac aguaagacau uc 22
<210> 7369
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7369
aauugccaau cccuugugac au 22
<210> 7370
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7370
aauugucccc agggacaaaa ca 22
<210> 7371
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7371
aauuuggcca gacacaggug cc 22
<210> 7372
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7372
acaaaaaauc cccacuaucu gu 22
<210> 7373
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7373
acaaacccac cucgaaagac ac 22
<210> 7374
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7374
acaaagauua uuugcacgaa cu 22
<210> 7375
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7375
acaaagcucu ggcaggcaau gc 22
<210> 7376
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7376
acaaagugca aacauaacaa aa 22
<210> 7377
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7377
acaaauacag caaccagggu uu 22
<210> 7378
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7378
acaaaugcca aauguacaca gu 22
<210> 7379
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7379
acaacagcag auggcaccaa cg 22
<210> 7380
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7380
acaacgggga caucauucuc cc 22
<210> 7381
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7381
acaacucuga acugagaaag ug 22
<210> 7382
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7382
acaagauugg ggaagugaau gg 22
<210> 7383
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7383
acaaggccgg cgaggucuca gg 22
<210> 7384
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7384
acaagggauu ggcaauuguc cc 22
<210> 7385
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7385
acaauccuca aacauggaag au 22
<210> 7386
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7386
acaauggcag uucucgauau uc 22
<210> 7387
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7387
acaauugcca aucccuugug ac 22
<210> 7388
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7388
acacaaaugc caaauguaca ca 22
<210> 7389
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7389
acacaacagc agauggcacc aa 22
<210> 7390
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7390
acacaauccu caaacaugga ag 22
<210> 7391
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7391
acacacaaca gcagauggca cc 22
<210> 7392
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7392
acacacacga cagaaaacag ug 22
<210> 7393
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7393
acacacgaca gaaaacagug ca 22
<210> 7394
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7394
acacagggcc ccgagaauag uc 22
<210> 7395
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7395
acacaggugc cucacgccug ua 22
<210> 7396
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7396
acacagucca guucgugcaa au 22
<210> 7397
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7397
acacagugua caacucugaa cu 22
<210> 7398
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7398
acacaguguu uugucccugg gg 22
<210> 7399
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7399
acacauaccc aucaacgaca ag 22
<210> 7400
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7400
acaccagccu ggugcccauc cu 22
<210> 7401
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7401
acacccaucu cccagaagcc ac 22
<210> 7402
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7402
acacccgguu accuuggccg ug 22
<210> 7403
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7403
acaccuccau uucucuccag ga 22
<210> 7404
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7404
acaccugggu gcaggccacg ug 22
<210> 7405
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7405
acacgacaga aaacagugca aa 22
<210> 7406
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7406
acacggcgau uucagaaaga ac 22
<210> 7407
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7407
acacgggcuu ucccuggccu gg 22
<210> 7408
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7408
acacguggcc ugcacccagg ug 22
<210> 7409
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7409
acacguugac uccugaguuu ag 22
<210> 7410
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7410
acacugggug ggucaugauu cg 22
<210> 7411
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7411
acacugugua cauuuggcau uu 22
<210> 7412
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7412
acagagaaga ccaaagcauu gc 22
<210> 7413
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7413
acagagaggg gcagguugac cg 22
<210> 7414
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7414
acagauagug gggauuuuuu gu 22
<210> 7415
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7415
acagaugaag acccuauuuc ag 22
<210> 7416
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7416
acagaugguc agucuggagg au 22
<210> 7417
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7417
acagcaacca ggguuugcaa aa 22
<210> 7418
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7418
acagcagaug gcaccaacgg ga 22
<210> 7419
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7419
acagccacac cugggugcag gc 22
<210> 7420
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7420
acagccaggu uagccuuugc cc 22
<210> 7421
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7421
acagccucaa augccugagc uc 22
<210> 7422
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7422
acagccuccg ucagacuccc gc 22
<210> 7423
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7423
acaggcacgu gccaccguac cc 22
<210> 7424
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7424
acaggcccgg ggggaccagg au 22
<210> 7425
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7425
acaggcguga ggcaccugug uc 22
<210> 7426
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7426
acaggcuucg gacagugccc au 22
<210> 7427
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7427
acagggacgc auuuacgugc uc 22
<210> 7428
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7428
acagggcaaa ggcuaaccug gc 22
<210> 7429
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7429
acagggcccc gagaauaguc ac 22
<210> 7430
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7430
acaggugccu cacgccugua au 22
<210> 7431
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7431
acaguaacac ggcgauuuca ga 22
<210> 7432
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7432
acaguaagac auucaggcua ca 22
<210> 7433
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7433
acaguccagu ucgugcaaau aa 22
<210> 7434
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7434
acagugacag ccuccgucag ac 22
<210> 7435
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7435
acagugcaaa auaauaacac aa 22
<210> 7436
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7436
acagugccca ugcaauggcu ug 22
<210> 7437
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7437
acagugguuu aaaaagugac ac 22
<210> 7438
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7438
acaguguaca acucugaacu ga 22
<210> 7439
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7439
acaguguuuu gucccugggg ac 22
<210> 7440
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7440
acaguuucaa ccaauauaca aa 22
<210> 7441
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7441
acauaaagaa gaggcauuuc ag 22
<210> 7442
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7442
acauaaagac gacaauggca gu 22
<210> 7443
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7443
acauaacaaa aaauccccac ua 22
<210> 7444
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7444
acauacaacg gggacaucau uc 22
<210> 7445
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7445
acauacccau caacgacaag au 22
<210> 7446
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7446
acaucagugc aacaguaaca cg 22
<210> 7447
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7447
acaucauucu cccaaaaagc gu 22
<210> 7448
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7448
acauccccuc cccuuucauc uu 22
<210> 7449
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7449
acaucugccu ggagucccgu cc 22
<210> 7450
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7450
acaucuucac gcgggagucu ga 22
<210> 7451
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7451
acaugcacgg ugaggccggg cg 22
<210> 7452
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7452
acauggaaga ugaaagggga gg 22
<210> 7453
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7453
acauucaggc uacaaaaacc uu 22
<210> 7454
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7454
accaaaaagu uaaaaaucag cu 22
<210> 7455
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7455
accaaaaucc caacccaagc ca 22
<210> 7456
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7456
accaaacuca uucaccaaau ga 22
<210> 7457
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7457
accaaagcau ugccugccag ag 22
<210> 7458
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7458
accaaaugau gccacuuccc ag 22
<210> 7459
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7459
accaacggga cccccuggcc cu 22
<210> 7460
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7460
accaaucucu aagccaaacc cc 22
<210> 7461
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7461
accacggauu cagccagauc au 22
<210> 7462
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7462
accacgggaa uggaaguggg ua 22
<210> 7463
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7463
accacuguau agaagguuuu ug 22
<210> 7464
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7464
accagaaagg cuuaucacgg uu 22
<210> 7465
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7465
accagccugg ugcccauccu cc 22
<210> 7466
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7466
accaggauga caccuccauu uc 22
<210> 7467
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7467
accaggccug agcaacaaag cg 22
<210> 7468
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7468
accaggcugg uguccugaca gc 22
<210> 7469
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7469
accagugacu caggcucugc cu 22
<210> 7470
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7470
accauccucc caccucagcc uc 22
<210> 7471
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7471
accaugcaug gugcaucagc ag 22
<210> 7472
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7472
acccaagcca uugcaugggc ac 22
<210> 7473
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7473
acccacccag ugucuuucga gg 22
<210> 7474
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7474
acccaccucg aaagacacug gg 22
<210> 7475
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7475
acccacuucc auucccgugg uc 22
<210> 7476
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7476
acccagcuga uuuuuaacuu uu 22
<210> 7477
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7477
acccaggugu ggcugucagg ac 22
<210> 7478
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7478
acccaguguc uuucgaggug gg 22
<210> 7479
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7479
acccaucaac gacaagauug gg 22
<210> 7480
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7480
acccaucucc cagaagccac uc 22
<210> 7481
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7481
accccaucuc uuaaaaaaug aa 22
<210> 7482
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7482
acccccgaau caugacccac cc 22
<210> 7483
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7483
acccccuaca cagggccccg ag 22
<210> 7484
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7484
acccccuggc ccugccucau cc 22
<210> 7485
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7485
accccuaaac ucaggaguca ac 22
<210> 7486
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7486
accccuaccc acuuccauuc cc 22
<210> 7487
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7487
acccgguuac cuuggccgug ag 22
<210> 7488
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7488
acccugguug cuguauuugu uc 22
<210> 7489
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7489
acccuuaaua uuuauuaagu gc 22
<210> 7490
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7490
acccuuccug agaccucgcc gg 22
<210> 7491
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7491
accgagacca aacucauuca cc 22
<210> 7492
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7492
accgggacuu caaagccgug au 22
<210> 7493
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7493
accggguguc ucaggcacuu aa 22
<210> 7494
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7494
accguaccca gcugauuuuu aa 22
<210> 7495
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7495
accgugacac aauccucaaa ca 22
<210> 7496
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7496
accgugauaa gccuuucugg uu 22
<210> 7497
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7497
accgugcaug uuuuaaacac au 22
<210> 7498
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7498
accuagugcu uccacuucua ug 22
<210> 7499
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7499
accuccauuu cucuccagga ag 22
<210> 7500
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7500
accucgaaag acacugggug gg 22
<210> 7501
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7501
accucgccgg ccuuguuuua uu 22
<210> 7502
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7502
accucuucua ugcaagccuu gc 22
<210> 7503
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7503
accugaaguc ccgucaaacg au 22
<210> 7504
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7504
accugccccu cucugucccc gg 22
<210> 7505
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7505
accuggcugu cuagcaaggc uu 22
<210> 7506
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7506
accugggugc aggccacgug uc 22
<210> 7507
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7507
accugugucu ggccaaauuc au 22
<210> 7508
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7508
accuuccuua agccaggaaa gg 22
<210> 7509
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7509
accuucuaua cagugguuua aa 22
<210> 7510
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7510
accuuggccg ugaggacacg ug 22
<210> 7511
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7511
acgaacugga cugugugcaa cg 22
<210> 7512
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7512
acgacaagau uggggaagug aa 22
<210> 7513
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7513
acgacaaugg caguucucga ua 22
<210> 7514
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7514
acgacagaaa acagugcaaa au 22
<210> 7515
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7515
acgacagccu caaaugccug ag 22
<210> 7516
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7516
acgaggaaag gaagaaacca aa 22
<210> 7517
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7517
acgaucacgg cuuugaaguc cc 22
<210> 7518
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7518
acgauccaga cuggaggauu ua 22
<210> 7519
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7519
acgcauuuac gugcuccgaa ac 22
<210> 7520
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7520
acgccacguc auccuccaga cu 22
<210> 7521
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7521
acgccaugaa ucccuuuccu gg 22
<210> 7522
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7522
acgcgggagu cugacggagg cu 22
<210> 7523
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7523
acgcuuuuug ggagaaugau gu 22
<210> 7524
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7524
acggaggcug ucacugucuc uc 22
<210> 7525
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7525
acggauucag ccagaucauu uc 22
<210> 7526
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7526
acggccaagg uaaccgggug uc 22
<210> 7527
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7527
acggcgauuu cagaaagaac cu 22
<210> 7528
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7528
acggcuuuga agucccgguc aa 22
<210> 7529
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7529
acgggaaugg aaguggguag gg 22
<210> 7530
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7530
acgggacccc cuggcccugc cu 22
<210> 7531
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7531
acgggacucc aggcagaugu uc 22
<210> 7532
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7532
acgggacuuc agguucuuuc ug 22
<210> 7533
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7533
acgggcuuuc ccuggccugg ga 22
<210> 7534
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7534
acggggacau cauucuccca aa 22
<210> 7535
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7535
acggugaggc cgggcgcagu gg 22
<210> 7536
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7536
acgguggaga gaaacucaaa ac 22
<210> 7537
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7537
acguaaaugc gucccuguac ag 22
<210> 7538
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7538
acgucauccu ccagacugac ca 22
<210> 7539
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7539
acgugccacc guacccagcu ga 22
<210> 7540
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7540
acgugcuccg aaaccagaaa gg 22
<210> 7541
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7541
acguggccug cacccaggug ug 22
<210> 7542
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7542
acguggcgug aacaucugcc ug 22
<210> 7543
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7543
acguguccuc acggccaagg ua 22
<210> 7544
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7544
acguguuuac cucuucuaug ca 22
<210> 7545
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7545
acguugacuc cugaguuuag gg 22
<210> 7546
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7546
acuagguggg cggacauaaa ga 22
<210> 7547
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7547
acuaucugua cagggacgca uu 22
<210> 7548
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7548
acuauguugc ccaggcugga aa 22
<210> 7549
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7549
acuauucucg gggcccugug ua 22
<210> 7550
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7550
acucaaaacu uccuggagag aa 22
<210> 7551
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7551
acucaaguga uccagcucag cc 22
<210> 7552
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7552
acucaggagu caacguguuu ac 22
<210> 7553
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7553
acucaggcuc ugccucuggg aa 22
<210> 7554
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7554
acucauacau acaacgggga ca 22
<210> 7555
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7555
acucauucac caaaugaugc ca 22
<210> 7556
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7556
acuccaggca gauguucacg cc 22
<210> 7557
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7557
acucccgcgu gaagauguca ca 22
<210> 7558
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7558
acuccugaac ucaagugauc ca 22
<210> 7559
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7559
acuccugagu uuagggguuu gg 22
<210> 7560
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7560
acucugaacu gagaaagugc aa 22
<210> 7561
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7561
acugagaaag ugcaaggaga cc 22
<210> 7562
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7562
acugaugucc ggagagacag ug 22
<210> 7563
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7563
acugccauug ucgucuuuau gu 22
<210> 7564
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7564
acugcgcccg gccucaccgu gc 22
<210> 7565
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7565
acugcuuucc agccugggca ac 22
<210> 7566
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7566
acuggacugu gugcaacgcu uu 22
<210> 7567
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7567
acuggguggg ucaugauucg gg 22
<210> 7568
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7568
acuggucacc cuuaauauuu au 22
<210> 7569
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7569
acuguauaga agguuuuugu ag 22
<210> 7570
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7570
acuguccgaa gccuguucug cc 22
<210> 7571
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7571
acugucucuc cggacaucag ug 22
<210> 7572
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7572
acuguguaca uuuggcauuu gu 22
<210> 7573
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7573
acugugugca acgcuuuuug gg 22
<210> 7574
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7574
acuguugcac ugauguccgg ag 22
<210> 7575
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7575
acuguuuucu gucgugugug uu 22
<210> 7576
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7576
acuuaauaaa uauuaagggu ga 22
<210> 7577
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7577
acuucaaagc cgugaucgug aa 22
<210> 7578
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7578
acuucagguu cuuucugaaa uc 22
<210> 7579
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7579
acuuccauuc ccguggucuc cu 22
<210> 7580
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7580
acuucccaga ggcagagccu ga 22
<210> 7581
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7581
acuuccccaa ucuugucguu ga 22
<210> 7582
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7582
acuuccugga gagaaaugga gg 22
<210> 7583
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7583
acuucuaugc aaaugccucc aa 22
<210> 7584
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7584
acuugcuucu cugggccuga ca 22
<210> 7585
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7585
acuuucucag uucagaguug ua 22
<210> 7586
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7586
acuuugggag gcugagcugg au 22
<210> 7587
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7587
acuuuuuggu uuuuguagag au 22
<210> 7588
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7588
agaaacaggc ccggggggac ca 22
<210> 7589
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7589
agaaaccaaa aucccaaccc aa 22
<210> 7590
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7590
agaaacucaa aacuuccugg ag 22
<210> 7591
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7591
agaaagaacc ugaagucccg uc 22
<210> 7592
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7592
agaaaggcuu aucacgguuc cc 22
<210> 7593
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7593
agaaagugca aggagaccac gg 22
<210> 7594
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7594
agaaauggag gugucauccu gg 22
<210> 7595
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7595
agaacaggcu ucggacagug cc 22
<210> 7596
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7596
agaacccuuc cugagaccuc gc 22
<210> 7597
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7597
agaaccugaa gucccgucaa ac 22
<210> 7598
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7598
agaacugcca uugucgucuu ua 22
<210> 7599
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7599
agaagaccaa agcauugccu gc 22
<210> 7600
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7600
agaagaggca uuucagaggc aa 22
<210> 7601
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7601
agaagaggua aacacguuga cu 22
<210> 7602
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7602
agaagcaagu ggcuuucaac ac 22
<210> 7603
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7603
agaagccacu cauacauaca ac 22
<210> 7604
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7604
agaagguuuu uguagccuga au 22
<210> 7605
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7605
agaaguggaa gcacuaggug gg 22
<210> 7606
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7606
agaauaguca cugaacaaau ac 22
<210> 7607
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7607
agaaugaugu ccccguugua ug 22
<210> 7608
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7608
agacacaggu gccucacgcc ug 22
<210> 7609
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7609
agacacccgg uuaccuuggc cg 22
<210> 7610
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7610
agacacuggg ugggucauga uu 22
<210> 7611
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7611
agacagagaa gaccaaagca uu 22
<210> 7612
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7612
agacagaugg ucagucugga gg 22
<210> 7613
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7613
agacagccag guuagccuuu gc 22
<210> 7614
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7614
agacagugac agccuccguc ag 22
<210> 7615
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7615
agacauucag gcuacaaaaa cc 22
<210> 7616
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7616
agaccaaacu cauucaccaa au 22
<210> 7617
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7617
agaccaaagc auugccugcc ag 22
<210> 7618
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7618
agaccacggg aauggaagug gg 22
<210> 7619
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7619
agaccaggcc ugagcaacaa ag 22
<210> 7620
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7620
agaccccauc ucuuaaaaaa ug 22
<210> 7621
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7621
agaccucgcc ggccuuguuu ua 22
<210> 7622
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7622
agacgacaau ggcaguucuc ga 22
<210> 7623
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7623
agacucccgc gugaagaugu ca 22
<210> 7624
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7624
agagaaacag gcccgggggg ac 22
<210> 7625
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7625
agagaaacuc aaaacuuccu gg 22
<210> 7626
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7626
agagaaaugg aggugucauc cu 22
<210> 7627
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7627
agagaagacc aaagcauugc cu 22
<210> 7628
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7628
agagaagcaa guggcuuuca ac 22
<210> 7629
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7629
agagacagug acagccuccg uc 22
<210> 7630
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7630
agagaggggc agguugaccg gg 22
<210> 7631
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7631
agagauggga ucucgcuuug uu 22
<210> 7632
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7632
agagauuggu ggaugaggca gg 22
<210> 7633
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7633
agagccugag ucacugguca cc 22
<210> 7634
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7634
agaggcaaua acccccuaca ca 22
<210> 7635
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7635
agaggcagag ccugagucac ug 22
<210> 7636
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7636
agaggcauuu cagaggcaau aa 22
<210> 7637
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7637
agaggccaug ggcugcugau gc 22
<210> 7638
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7638
agaggggcag guugaccggg ac 22
<210> 7639
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7639
agagguaaac acguugacuc cu 22
<210> 7640
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7640
agaguuguac acuguguaca uu 22
<210> 7641
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7641
agauaguggg gauuuuuugu ua 22
<210> 7642
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7642
agaucauuuc cgacgccaug aa 22
<210> 7643
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7643
agaucccauc ucuacaaaaa cc 22
<210> 7644
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7644
agaugaaagg ggaggggaug uc 22
<210> 7645
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7645
agaugaagac ccuauuucag aa 22
<210> 7646
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7646
agauggcacc aacgggaccc cc 22
<210> 7647
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7647
agaugggauc ucgcuuuguu gc 22
<210> 7648
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7648
agaugggugu cacuuuuuaa ac 22
<210> 7649
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7649
agauggucag ucuggaggau ga 22
<210> 7650
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7650
agaugucaca agggauuggc aa 22
<210> 7651
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7651
agauguucac gccacgucau cc 22
<210> 7652
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7652
agauuauuug cacgaacugg ac 22
<210> 7653
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7653
agauugggga agugaauggc uu 22
<210> 7654
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7654
agauuggugg augaggcagg gc 22
<210> 7655
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7655
agcaaccagg guuugcaaaa au 22
<210> 7656
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7656
agcaaggcuu gcauagaaga gg 22
<210> 7657
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7657
agcaaguggc uuucaacaca ca 22
<210> 7658
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7658
agcacguaaa ugcgucccug ua 22
<210> 7659
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7659
agcacuaggu gggcggacau aa 22
<210> 7660
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7660
agcacuuugg gaggcugagc ug 22
<210> 7661
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7661
agcagauggc accaacggga cc 22
<210> 7662
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7662
agcagcccau ggccucuggc ca 22
<210> 7663
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7663
agcaguggca uaaucauagc uc 22
<210> 7664
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7664
agcauugccu gccagagcuu ug 22
<210> 7665
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7665
agccaaaccc cuaaacucag ga 22
<210> 7666
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7666
agccacaccu gggugcaggc ca 22
<210> 7667
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7667
agccacucau acauacaacg gg 22
<210> 7668
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7668
agccacugcg cccggccuca cc 22
<210> 7669
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7669
agccacuugc uucucugggc cu 22
<210> 7670
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7670
agccagauca uuuccgacgc ca 22
<210> 7671
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7671
agccaggaaa gggauucaug gc 22
<210> 7672
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7672
agccagguua gccuuugccc ug 22
<210> 7673
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7673
agccauucac uuccccaauc uu 22
<210> 7674
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7674
agccauugca ugggcacugu cc 22
<210> 7675
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7675
agcccauggc cucuggccag gc 22
<210> 7676
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7676
agcccguguc aaugaaugcc gg 22
<210> 7677
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7677
agccgugauc gugaauaucg ag 22
<210> 7678
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7678
agccucaaau gccugagcuc aa 22
<210> 7679
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7679
agccuccguc agacucccgc gu 22
<210> 7680
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7680
agccucgcca ugccuggcca ga 22
<210> 7681
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7681
agccugaaug ucuuacugug au 22
<210> 7682
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7682
agccugaguc acuggucacc cu 22
<210> 7683
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7683
agccuggugc ccauccuccc ga 22
<210> 7684
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7684
agccuguucu gccucccaga ug 22
<210> 7685
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7685
agccuugcua gacagccagg uu 22
<210> 7686
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7686
agccuuucug guuucggagc ac 22
<210> 7687
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7687
agccuuugcc cugucacccc cg 22
<210> 7688
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7688
agcgagaucc caucucuaca aa 22
<210> 7689
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7689
agcguugcac acaguccagu uc 22
<210> 7690
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7690
agcuaugauu augccacugc uu 22
<210> 7691
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7691
agcucacgac agccucaaau gc 22
<210> 7692
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7692
agcucaggca uuugaggcug uc 22
<210> 7693
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7693
agcucuggca ggcaaugcuu ug 22
<210> 7694
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7694
agcuggauca cuugaguuca gg 22
<210> 7695
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7695
agcuggguac gguggcacgu gc 22
<210> 7696
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7696
aggaaaggaa gaaaccaaaa uc 22
<210> 7697
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7697
aggaaaggga uucauggcgu cg 22
<210> 7698
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7698
aggaagaaac caaaauccca ac 22
<210> 7699
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7699
aggaaggguu cugggcaggg ac 22
<210> 7700
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7700
aggaagguac aaacccaccu cg 22
<210> 7701
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7701
aggaaguuuu gaguuucucu cc 22
<210> 7702
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7702
aggacaccag ccuggugccc au 22
<210> 7703
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7703
aggacacgug gccugcaccc ag 22
<210> 7704
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7704
aggagaccac gggaauggaa gu 22
<210> 7705
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7705
aggagucaac guguuuaccu cu 22
<210> 7706
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7706
aggaguugga gaccaggccu ga 22
<210> 7707
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7707
aggauaagag aaacaggccc gg 22
<210> 7708
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7708
aggaugacac cuccauuucu cu 22
<210> 7709
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7709
aggaugacgu ggcgugaaca uc 22
<210> 7710
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7710
aggaugggca ccaggcuggu gu 22
<210> 7711
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7711
aggaugguuu gagcucaggc au 22
<210> 7712
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7712
aggauugugu cacgguggag ag 22
<210> 7713
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7713
aggcaauaac ccccuacaca gg 22
<210> 7714
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7714
aggcaaugcu uuggucuucu cu 22
<210> 7715
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7715
aggcaccugu gucuggccaa au 22
<210> 7716
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7716
aggcacgugc caccguaccc ag 22
<210> 7717
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7717
aggcacuuaa uaaauauuaa gg 22
<210> 7718
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7718
aggcagaaca ggcuucggac ag 22
<210> 7719
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7719
aggcagagcc ugagucacug gu 22
<210> 7720
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7720
aggcagaugu ucacgccacg uc 22
<210> 7721
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7721
aggcagggcc aggggguccc gu 22
<210> 7722
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7722
aggcauggcg aggcugaggu gg 22
<210> 7723
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7723
aggcauuuca gaggcaauaa cc 22
<210> 7724
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7724
aggcauuuga ggcugucgug ag 22
<210> 7725
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7725
aggcauuugc auagaagugg aa 22
<210> 7726
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7726
aggccacgug uccucacggc ca 22
<210> 7727
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7727
aggccauggg cugcugaugc ac 22
<210> 7728
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7728
aggcccagag aagcaagugg cu 22
<210> 7729
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7729
aggcccgggg ggaccaggau ga 22
<210> 7730
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7730
aggccggcga ggucucagga ag 22
<210> 7731
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7731
aggccugagc aacaaagcga ga 22
<210> 7732
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7732
aggccugguc uccaacuccu ga 22
<210> 7733
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7733
aggcgugagg caccuguguc ug 22
<210> 7734
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7734
aggcuaaccu ggcugucuag ca 22
<210> 7735
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7735
aggcuacaaa aaccuucuau ac 22
<210> 7736
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7736
aggcucugcc ucugggaagu gg 22
<210> 7737
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7737
aggcugagcu ggaucacuug ag 22
<210> 7738
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7738
aggcuggaaa gcaguggcau aa 22
<210> 7739
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7739
aggcuggugu ccugacagcc ac 22
<210> 7740
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7740
aggcugucac ugucucuccg ga 22
<210> 7741
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7741
aggcuuauca cgguucccug ca 22
<210> 7742
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7742
aggcuucgga cagugcccau gc 22
<210> 7743
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7743
aggcuugcau agaagaggua aa 22
<210> 7744
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7744
agggaaagcc cgugucaaug aa 22
<210> 7745
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7745
agggaaccgu gauaagccuu uc 22
<210> 7746
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7746
agggacgcau uuacgugcuc cg 22
<210> 7747
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7747
agggacggga cuccaggcag au 22
<210> 7748
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7748
agggauucau ggcgucggaa au 22
<210> 7749
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7749
agggauuggc aauugucccc ag 22
<210> 7750
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7750
agggcaaagg cuaaccuggc ug 22
<210> 7751
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7751
agggccaggg ggucccguug gu 22
<210> 7752
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7752
agggccccga gaauagucac ug 22
<210> 7753
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7753
aggggagggg augucaggcc ca 22
<210> 7754
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7754
aggggauguc aggcccagag aa 22
<210> 7755
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7755
aggggcaggu ugaccgggac uu 22
<210> 7756
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7756
aggggguccc guuggugcca uc 22
<210> 7757
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7757
aggggguuau ugccucugaa au 22
<210> 7758
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7758
aggggucggg aggaugggca cc 22
<210> 7759
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7759
agggguuugg cuuagagauu gg 22
<210> 7760
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7760
agggugacca gugacucagg cu 22
<210> 7761
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7761
aggguucugg gcagggacgg ga 22
<210> 7762
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7762
agguaaacac guugacuccu ga 22
<210> 7763
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7763
agguaaccgg gugucucagg ca 22
<210> 7764
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7764
agguacaaac ccaccucgaa ag 22
<210> 7765
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7765
aggucucagg aaggguucug gg 22
<210> 7766
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7766
aggugggagg augguuugag cu 22
<210> 7767
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7767
aggugggcgg acauaaagac ga 22
<210> 7768
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7768
agguggguuu guaccuuccu ua 22
<210> 7769
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7769
aggugucauc cugguccccc cg 22
<210> 7770
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7770
agguguggcu gucaggacac ca 22
<210> 7771
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7771
agguuagccu uugcccuguc ac 22
<210> 7772
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7772
agguucuuuc ugaaaucgcc gu 22
<210> 7773
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7773
agguugaccg ggacuucaaa gc 22
<210> 7774
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7774
agguuuuugu agccugaaug uc 22
<210> 7775
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7775
aguaacacgg cgauuucaga aa 22
<210> 7776
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7776
aguaagacau ucaggcuaca aa 22
<210> 7777
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7777
aguaagaccc caucucuuaa aa 22
<210> 7778
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7778
agucaacgug uuuaccucuu cu 22
<210> 7779
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7779
agucacugaa caaauacagc aa 22
<210> 7780
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7780
agucacuggu cacccuuaau au 22
<210> 7781
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7781
aguccaguuc gugcaaauaa uc 22
<210> 7782
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7782
agucccgguc aaccugcccc uc 22
<210> 7783
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7783
agucccguca aacgauccag ac 22
<210> 7784
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7784
agucccgucc cugcccagaa cc 22
<210> 7785
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7785
agucugacgg aggcugucac ug 22
<210> 7786
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7786
agucuggagg augacguggc gu 22
<210> 7787
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7787
agucuggauc guuugacggg ac 22
<210> 7788
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7788
agugaauggc uuggaggcau uu 22
<210> 7789
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7789
agugacaccc aucucccaga ag 22
<210> 7790
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7790
agugacagcc uccgucagac uc 22
<210> 7791
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7791
agugacuauu cucggggccc ug 22
<210> 7792
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7792
agugacucag gcucugccuc ug 22
<210> 7793
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7793
agugauccag cucagccucc ca 22
<210> 7794
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7794
agugcaaaca uaacaaaaaa uc 22
<210> 7795
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7795
agugcaacag uaacacggcg au 22
<210> 7796
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7796
agugcaagga gaccacggga au 22
<210> 7797
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7797
agugcaggga accgugauaa gc 22
<210> 7798
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7798
agugcccaug caauggcuug gg 22
<210> 7799
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7799
agugccugag acacccgguu ac 22
<210> 7800
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7800
agugcuucca cuucuaugca aa 22
<210> 7801
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7801
aguggaagca cuaggugggc gg 22
<210> 7802
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7802
aguggcauca uuuggugaau ga 22
<210> 7803
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7803
aguggcuucu gggagauggg ug 22
<210> 7804
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7804
aguggcuuuc aacacacaac ag 22
<210> 7805
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7805
aguggggauu uuuuguuaug uu 22
<210> 7806
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7806
aguggguagg ggucgggagg au 22
<210> 7807
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7807
agugguuuaa aaagugacac cc 22
<210> 7808
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7808
aguguacaac ucugaacuga ga 22
<210> 7809
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7809
agugucuuuc gagguggguu ug 22
<210> 7810
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7810
aguguuuugu cccuggggac aa 22
<210> 7811
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7811
aguuaaaaau cagcugggua cg 22
<210> 7812
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7812
aguucagagu uguacacugu gu 22
<210> 7813
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7813
aguucaggag uuggagacca gg 22
<210> 7814
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7814
aguucucgau auucacgauc ac 22
<210> 7815
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7815
aguuggagac caggccugag ca 22
<210> 7816
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7816
aguuguacac uguguacauu ug 22
<210> 7817
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7817
aguuguauuu cugaaauagg gu 22
<210> 7818
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7818
aguuuagggg uuuggcuuag ag 22
<210> 7819
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7819
aguuucaacc aauauacaaa gu 22
<210> 7820
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7820
aguuucucuc caccgugaca ca 22
<210> 7821
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7821
aguuuggucu cggugccacc ac 22
<210> 7822
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7822
aguuuugagu uucucuccac cg 22
<210> 7823
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7823
auaaaacaaa gcucuggcag gc 22
<210> 7824
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7824
auaaaacaag gccggcgagg uc 22
<210> 7825
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7825
auaaagaaga ggcauuucag ag 22
<210> 7826
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7826
auaaagacga caauggcagu uc 22
<210> 7827
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7827
auaaauaaau ccuccagucu gg 22
<210> 7828
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7828
auaaauauua agggugacca gu 22
<210> 7829
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7829
auaaauccuc cagucuggau cg 22
<210> 7830
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7830
auaacaaaaa auccccacua uc 22
<210> 7831
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7831
auaacacaaa ugccaaaugu ac 22
<210> 7832
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7832
auaacccccu acacagggcc cc 22
<210> 7833
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7833
auaagagaaa caggcccggg gg 22
<210> 7834
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7834
auaagccuuu cugguuucgg ag 22
<210> 7835
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7835
auaaucauag cucacgacag cc 22
<210> 7836
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7836
auacaacggg gacaucauuc uc 22
<210> 7837
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7837
auacagcaac caggguuugc aa 22
<210> 7838
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7838
auacaguggu uuaaaaagug ac 22
<210> 7839
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7839
auacauacaa cggggacauc au 22
<210> 7840
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7840
auacccauca acgacaagau ug 22
<210> 7841
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7841
auagaagagg uaaacacguu ga 22
<210> 7842
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7842
auagaagguu uuuguagccu ga 22
<210> 7843
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7843
auagaagugg aagcacuagg ug 22
<210> 7844
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7844
auagcucacg acagccucaa au 22
<210> 7845
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7845
auaguaagac cccaucucuu aa 22
<210> 7846
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7846
auagucacug aacaaauaca gc 22
<210> 7847
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7847
auagugggga uuuuuuguua ug 22
<210> 7848
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7848
auaguuguau uucugaaaua gg 22
<210> 7849
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7849
auauaaaaca aagcucuggc ag 22
<210> 7850
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7850
auauauaaaa caaagcucug gc 22
<210> 7851
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7851
auauauuuau ucaucuggga gg 22
<210> 7852
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7852
auaucgagaa cugccauugu cg 22
<210> 7853
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7853
auauuaaggg ugaccaguga cu 22
<210> 7854
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7854
auauucacga ucacggcuuu ga 22
<210> 7855
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7855
auauuuauua agugccugag ac 22
<210> 7856
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7856
auauuuauuc aucugggagg ca 22
<210> 7857
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7857
aucaacgaca agauugggga ag 22
<210> 7858
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7858
aucacaggca cgugccaccg ua 22
<210> 7859
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7859
aucacaguaa gacauucagg cu 22
<210> 7860
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7860
aucacggcuu ugaagucccg gu 22
<210> 7861
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7861
aucagcagcc cauggccucu gg 22
<210> 7862
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7862
aucagcuggg uacgguggca cg 22
<210> 7863
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7863
aucagugcaa caguaacacg gc 22
<210> 7864
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7864
aucauagcuc acgacagccu ca 22
<210> 7865
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7865
aucaugaccc acccaguguc uu 22
<210> 7866
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7866
aucauucucc caaaaagcgu ug 22
<210> 7867
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7867
aucauuuccg acgccaugaa uc 22
<210> 7868
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7868
aucauuuggu gaaugaguuu gg 22
<210> 7869
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7869
auccaccaau cucuaagcca aa 22
<210> 7870
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7870
aucccaacac acacgacaga aa 22
<210> 7871
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7871
aucccaaccc aagccauugc au 22
<210> 7872
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7872
aucccaggcc agggaaagcc cg 22
<210> 7873
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7873
aucccaucuc uacaaaaacc aa 22
<210> 7874
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7874
auccccacua ucuguacagg ga 22
<210> 7875
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7875
auccccuccc cuuucaucuu cc 22
<210> 7876
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7876
aucccuugug acaucuucac gc 22
<210> 7877
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7877
aucccuuucc uggcuuaagg aa 22
<210> 7878
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7878
auccguggug gcaccgagac ca 22
<210> 7879
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7879
auccucaaac auggaagaug aa 22
<210> 7880
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7880
auccuccagu cuggaucguu ug 22
<210> 7881
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7881
auccucccac cucagccucg cc 22
<210> 7882
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7882
auccucccga ccccuaccca cu 22
<210> 7883
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7883
auccuggucc ccccgggccu gu 22
<210> 7884
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7884
auccuucacg aggaaaggaa ga 22
<210> 7885
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7885
aucgagaacu gccauugucg uc 22
<210> 7886
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7886
aucgccgugu uacuguugca cu 22
<210> 7887
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7887
aucgugaaua ucgagaacug cc 22
<210> 7888
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7888
aucguuugac gggacuucag gu 22
<210> 7889
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7889
aucuauuuau uuuugcaaac cc 22
<210> 7890
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7890
aucucccaga agccacucau ac 22
<210> 7891
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7891
aucucgcuuu guugcucagg cc 22
<210> 7892
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7892
aucucuaagc caaaccccua aa 22
<210> 7893
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7893
aucucuuaaa aaaugaauuu gg 22
<210> 7894
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7894
aucugccugg agucccgucc cu 22
<210> 7895
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7895
aucugcuguu guguguugaa ag 22
<210> 7896
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7896
aucuggcuga auccguggug gc 22
<210> 7897
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7897
aucugggagg cagaacaggc uu 22
<210> 7898
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7898
aucuguacag ggacgcauuu ac 22
<210> 7899
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7899
aucuucacgc gggagucuga cg 22
<210> 7900
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7900
aucuuccaug uuugaggauu gu 22
<210> 7901
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7901
aucuugucgu ugauggguau gu 22
<210> 7902
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7902
aucuuuguac auaaagaaga gg 22
<210> 7903
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7903
augaaagggg aggggauguc ag 22
<210> 7904
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7904
augaagaccc uauuucagaa au 22
<210> 7905
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7905
augaaucccu uuccuggcuu aa 22
<210> 7906
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7906
augaaugccg gggacagaga gg 22
<210> 7907
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7907
augaauuugg ccagacacag gu 22
<210> 7908
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7908
augacaccuc cauuucucuc ca 22
<210> 7909
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7909
augacccacc cagugucuuu cg 22
<210> 7910
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7910
augacguggc gugaacaucu gc 22
<210> 7911
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7911
augaggcagg gccagggggu cc 22
<210> 7912
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7912
augaguggcu ucugggagau gg 22
<210> 7913
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7913
augaguuugg ucucggugcc ac 22
<210> 7914
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7914
augaucuggc ugaauccgug gu 22
<210> 7915
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7915
augaugccac uucccagagg ca 22
<210> 7916
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7916
augauguccc cguuguaugu au 22
<210> 7917
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7917
augauuaugc cacugcuuuc ca 22
<210> 7918
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7918
augauucggg ggugacaggg ca 22
<210> 7919
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7919
augcaaaugc cuccaagcca uu 22
<210> 7920
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7920
augcaagccu ugcuagacag cc 22
<210> 7921
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7921
augcaauggc uuggguuggg au 22
<210> 7922
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7922
augcacggug aggccgggcg ca 22
<210> 7923
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7923
augcauggug caucagcagc cc 22
<210> 7924
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7924
augccaaaug uacacagugu ac 22
<210> 7925
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7925
augccacuuc ccagaggcag ag 22
<210> 7926
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7926
augccgggga cagagagggg ca 22
<210> 7927
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7927
augccuccaa gccauucacu uc 22
<210> 7928
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7928
augccugagc ucaaaccauc cu 22
<210> 7929
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7929
augccuggcc agaggccaug gg 22
<210> 7930
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7930
augcgucccu guacagauag ug 22
<210> 7931
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7931
augcuuuggu cuucucuguc uu 22
<210> 7932
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7932
auggaagaug aaaggggagg gg 22
<210> 7933
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7933
auggaagugg guaggggucg gg 22
<210> 7934
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7934
auggaggugu cauccugguc cc 22
<210> 7935
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7935
auggcaccaa cgggaccccc ug 22
<210> 7936
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7936
auggcaguuc ucgauauuca cg 22
<210> 7937
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7937
auggccucug gccaggcaug gc 22
<210> 7938
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7938
auggcgaggc ugagguggga gg 22
<210> 7939
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7939
auggcgucgg aaaugaucug gc 22
<210> 7940
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7940
auggcuugga ggcauuugca ua 22
<210> 7941
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7941
auggcuuggg uugggauuuu gg 22
<210> 7942
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7942
augggauccc aggccaggga aa 22
<210> 7943
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7943
augggaucuc gcuuuguugc uc 22
<210> 7944
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7944
augggcacca ggcugguguc cu 22
<210> 7945
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7945
augggcacug uccgaagccu gu 22
<210> 7946
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7946
augggcugcu gaugcaccau gc 22
<210> 7947
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7947
auggguaugu guuuaaaaca ug 22
<210> 7948
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7948
auggguguca cuuuuuaaac ca 22
<210> 7949
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7949
auggucaguc uggaggauga cg 22
<210> 7950
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7950
auggugcauc agcagcccau gg 22
<210> 7951
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7951
augguuugag cucaggcauu ug 22
<210> 7952
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7952
auguacaaag auuauuugca cg 22
<210> 7953
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7953
auguacacag uguacaacuc ug 22
<210> 7954
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7954
auguaugagu ggcuucuggg ag 22
<210> 7955
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7955
augucacaag ggauuggcaa uu 22
<210> 7956
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7956
augucaggcc cagagaagca ag 22
<210> 7957
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7957
auguccccgu uguauguaug ag 22
<210> 7958
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7958
auguccgccc accuagugcu uc 22
<210> 7959
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7959
auguccggag agacagugac ag 22
<210> 7960
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7960
auguguuuaa aacaugcacg gu 22
<210> 7961
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7961
auguucacgc cacgucaucc uc 22
<210> 7962
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7962
auguugccca ggcuggaaag ca 22
<210> 7963
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7963
auguuugagg auugugucac gg 22
<210> 7964
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7964
auguuuuaaa cacauaccca uc 22
<210> 7965
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7965
auuaagggug accagugacu ca 22
<210> 7966
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7966
auuaagugcc ugagacaccc gg 22
<210> 7967
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7967
auuacaggcg ugaggcaccu gu 22
<210> 7968
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7968
auuaugccac ugcuuuccag cc 22
<210> 7969
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7969
auuauuugca cgaacuggac ug 22
<210> 7970
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7970
auuauuuugc acuguuuucu gu 22
<210> 7971
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7971
auucaaagac agagaagacc aa 22
<210> 7972
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7972
auucaccaaa ugaugccacu uc 22
<210> 7973
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7973
auucacgauc acggcuuuga ag 22
<210> 7974
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7974
auucacuucc ccaaucuugu cg 22
<210> 7975
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7975
auucagccag aucauuuccg ac 22
<210> 7976
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7976
auucaggcua caaaaaccuu cu 22
<210> 7977
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7977
auucaucugg gaggcagaac ag 22
<210> 7978
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7978
auucauggcg ucggaaauga uc 22
<210> 7979
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7979
auucauugac acgggcuuuc cc 22
<210> 7980
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7980
auucauuuuu uaagagaugg gg 22
<210> 7981
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7981
auucccgugg ucuccuugca cu 22
<210> 7982
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7982
auucgggggu gacagggcaa ag 22
<210> 7983
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7983
auucucccaa aaagcguugc ac 22
<210> 7984
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7984
auucucgggg cccuguguag gg 22
<210> 7985
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7985
auugacacgg gcuuucccug gc 22
<210> 7986
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7986
auugaucaca guaagacauu ca 22
<210> 7987
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7987
auugcauggg cacuguccga ag 22
<210> 7988
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7988
auugccaauc ccuugugaca uc 22
<210> 7989
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7989
auugccucug aaaugccucu uc 22
<210> 7990
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7990
auugccugcc agagcuuugu uu 22
<210> 7991
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7991
auuggcaauu guccccaggg ac 22
<210> 7992
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7992
auuggggaag ugaauggcuu gg 22
<210> 7993
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7993
auugguggau gaggcagggc ca 22
<210> 7994
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7994
auugucccca gggacaaaac ac 22
<210> 7995
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7995
auugucgucu uuauguccgc cc 22
<210> 7996
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7996
auugugucac gguggagaga aa 22
<210> 7997
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7997
auuuacgugc uccgaaacca ga 22
<210> 7998
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7998
auuuauuaag ugccugagac ac 22
<210> 7999
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 7999
auuuauucau cugggaggca ga 22
<210> 8000
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8000
auuuauuuuu gcaaacccug gu 22
<210> 8001
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8001
auuucagaaa gaaccugaag uc 22
<210> 8002
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8002
auuucagagg caauaacccc cu 22
<210> 8003
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8003
auuuccgacg ccaugaaucc cu 22
<210> 8004
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8004
auuucucucc aggaaguuuu ga 22
<210> 8005
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8005
auuucugaaa uagggucuuc au 22
<210> 8006
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8006
auuugaggcu gucgugagcu au 22
<210> 8007
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8007
auuugcacga acuggacugu gu 22
<210> 8008
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8008
auuugcauag aaguggaagc ac 22
<210> 8009
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8009
auuuggccag acacaggugc cu 22
<210> 8010
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8010
auuuggugaa ugaguuuggu cu 22
<210> 8011
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8011
auuuguucag ugacuauucu cg 22
<210> 8012
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8012
auuuugcacu guuuucuguc gu 22
<210> 8013
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8013
auuuugguuu cuuccuuucc uc 22
<210> 8014
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8014
auuuuugcaa acccugguug cu 22
<210> 8015
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8015
caaaaaaucc ccacuaucug ua 22
<210> 8016
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8016
caaaaagcgu ugcacacagu cc 22
<210> 8017
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8017
caaaaaguua aaaaucagcu gg 22
<210> 8018
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8018
caaaacuucc uggagagaaa ug 22
<210> 8019
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8019
caaaauccca acccaagcca uu 22
<210> 8020
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8020
caaacauaac aaaaaauccc ca 22
<210> 8021
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8021
caaacaugga agaugaaagg gg 22
<210> 8022
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8022
caaaccaucc ucccaccuca gc 22
<210> 8023
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8023
caaacccacc ucgaaagaca cu 22
<210> 8024
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8024
caaaccccua aacucaggag uc 22
<210> 8025
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8025
caaacccugg uugcuguauu ug 22
<210> 8026
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8026
caaacgaucc agacuggagg au 22
<210> 8027
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8027
caaacucauu caccaaauga ug 22
<210> 8028
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8028
caaagacaga gaagaccaaa gc 22
<210> 8029
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8029
caaagauuau uugcacgaac ug 22
<210> 8030
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8030
caaagcauug ccugccagag cu 22
<210> 8031
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8031
caaagccgug aucgugaaua uc 22
<210> 8032
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8032
caaagcgaga ucccaucucu ac 22
<210> 8033
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8033
caaagcucug gcaggcaaug cu 22
<210> 8034
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8034
caaaggcuaa ccuggcuguc ua 22
<210> 8035
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8035
caaagugcaa acauaacaaa aa 22
<210> 8036
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8036
caaauacagc aaccaggguu ug 22
<210> 8037
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8037
caaaugaugc cacuucccag ag 22
<210> 8038
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8038
caaaugccaa auguacacag ug 22
<210> 8039
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8039
caaaugccuc caagccauuc ac 22
<210> 8040
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8040
caaaugccug agcucaaacc au 22
<210> 8041
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8041
caaauguaca caguguacaa cu 22
<210> 8042
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8042
caaauucauu uuuuaagaga ug 22
<210> 8043
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8043
caacacacaa cagcagaugg ca 22
<210> 8044
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8044
caacacacac gacagaaaac ag 22
<210> 8045
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8045
caacagauga agacccuauu uc 22
<210> 8046
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8046
caacagcaga uggcaccaac gg 22
<210> 8047
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8047
caacaguaac acggcgauuu ca 22
<210> 8048
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8048
caaccaauau acaaagugca aa 22
<210> 8049
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8049
caaccagggu uugcaaaaau aa 22
<210> 8050
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8050
caacccaagc cauugcaugg gc 22
<210> 8051
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8051
caaccugccc cucucugucc cc 22
<210> 8052
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8052
caacgacaag auuggggaag ug 22
<210> 8053
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8053
caacgcuuuu ugggagaaug au 22
<210> 8054
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8054
caacgggacc cccuggcccu gc 22
<210> 8055
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8055
caacggggac aucauucucc ca 22
<210> 8056
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8056
caacguguuu accucuucua ug 22
<210> 8057
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8057
caacuccuga acucaaguga uc 22
<210> 8058
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8058
caacucugaa cugagaaagu gc 22
<210> 8059
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8059
caagauuggg gaagugaaug gc 22
<210> 8060
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8060
caagccauuc acuuccccaa uc 22
<210> 8061
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8061
caagccauug caugggcacu gu 22
<210> 8062
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8062
caagccuugc uagacagcca gg 22
<210> 8063
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8063
caaggagacc acgggaaugg aa 22
<210> 8064
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8064
caaggccggc gaggucucag ga 22
<210> 8065
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8065
caaggcuugc auagaagagg ua 22
<210> 8066
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8066
caagggauug gcaauugucc cc 22
<210> 8067
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8067
caagguaacc gggugucuca gg 22
<210> 8068
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8068
caagugaucc agcucagccu cc 22
<210> 8069
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8069
caaguggcuu ucaacacaca ac 22
<210> 8070
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8070
caauaacccc cuacacaggg cc 22
<210> 8071
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8071
caaucccuug ugacaucuuc ac 22
<210> 8072
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8072
caauccucaa acauggaaga ug 22
<210> 8073
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8073
caaucucuaa gccaaacccc ua 22
<210> 8074
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8074
caaucuuguc guugaugggu au 22
<210> 8075
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8075
caaugaaugc cggggacaga ga 22
<210> 8076
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8076
caaugcuuug gucuucucug uc 22
<210> 8077
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8077
caauggcagu ucucgauauu ca 22
<210> 8078
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8078
caauggcuug gguugggauu uu 22
<210> 8079
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8079
caauugccaa ucccuuguga ca 22
<210> 8080
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8080
caauuguccc cagggacaaa ac 22
<210> 8081
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8081
cacaaaugcc aaauguacac ag 22
<210> 8082
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8082
cacaacagca gauggcacca ac 22
<210> 8083
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8083
cacaagggau uggcaauugu cc 22
<210> 8084
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8084
cacaauccuc aaacauggaa ga 22
<210> 8085
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8085
cacacaacag cagauggcac ca 22
<210> 8086
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8086
cacacacgac agaaaacagu gc 22
<210> 8087
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8087
cacacagucc aguucgugca aa 22
<210> 8088
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8088
cacaccuggg ugcaggccac gu 22
<210> 8089
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8089
cacaggcacg ugccaccgua cc 22
<210> 8090
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8090
cacagggccc cgagaauagu ca 22
<210> 8091
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8091
cacaggugcc ucacgccugu aa 22
<210> 8092
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8092
cacaguaaga cauucaggcu ac 22
<210> 8093
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8093
cacaguccag uucgugcaaa ua 22
<210> 8094
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8094
cacaguguac aacucugaac ug 22
<210> 8095
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8095
cacaguguuu ugucccuggg ga 22
<210> 8096
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8096
cacauaccca ucaacgacaa ga 22
<210> 8097
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8097
caccaaauga ugccacuucc ca 22
<210> 8098
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8098
caccaacggg acccccuggc cc 22
<210> 8099
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8099
caccaaucuc uaagccaaac cc 22
<210> 8100
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8100
caccacggau ucagccagau ca 22
<210> 8101
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8101
caccagccug gugcccaucc uc 22
<210> 8102
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8102
caccaggcug guguccugac ag 22
<210> 8103
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8103
cacccaggug uggcugucag ga 22
<210> 8104
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8104
cacccagugu cuuucgaggu gg 22
<210> 8105
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8105
cacccaucuc ccagaagcca cu 22
<210> 8106
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8106
cacccccgaa ucaugaccca cc 22
<210> 8107
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8107
cacccgguua ccuuggccgu ga 22
<210> 8108
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8108
cacccuuaau auuuauuaag ug 22
<210> 8109
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8109
caccgagacc aaacucauuc ac 22
<210> 8110
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8110
caccguaccc agcugauuuu ua 22
<210> 8111
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8111
caccgugaca caauccucaa ac 22
<210> 8112
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8112
caccgugcau guuuuaaaca ca 22
<210> 8113
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8113
caccuagugc uuccacuucu au 22
<210> 8114
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8114
caccucagcc ucgccaugcc ug 22
<210> 8115
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8115
caccuccauu ucucuccagg aa 22
<210> 8116
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8116
caccucgaaa gacacugggu gg 22
<210> 8117
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8117
caccugggug caggccacgu gu 22
<210> 8118
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8118
cacgaacugg acugugugca ac 22
<210> 8119
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8119
cacgacagaa aacagugcaa aa 22
<210> 8120
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8120
cacgacagcc ucaaaugccu ga 22
<210> 8121
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8121
cacgaggaaa ggaagaaacc aa 22
<210> 8122
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8122
cacgaucacg gcuuugaagu cc 22
<210> 8123
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8123
cacgccacgu cauccuccag ac 22
<210> 8124
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8124
cacggauuca gccagaucau uu 22
<210> 8125
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8125
cacggccaag guaaccgggu gu 22
<210> 8126
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8126
cacggcgauu ucagaaagaa cc 22
<210> 8127
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8127
cacggcuuug aagucccggu ca 22
<210> 8128
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8128
cacgggaaug gaagugggua gg 22
<210> 8129
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8129
cacgggcuuu cccuggccug gg 22
<210> 8130
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8130
cacggugagg ccgggcgcag ug 22
<210> 8131
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8131
cacgguggag agaaacucaa aa 22
<210> 8132
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8132
cacguaaaug cgucccugua ca 22
<210> 8133
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8133
cacgucaucc uccagacuga cc 22
<210> 8134
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8134
cacgugccac cguacccagc ug 22
<210> 8135
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8135
cacguggccu gcacccaggu gu 22
<210> 8136
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8136
cacguguccu cacggccaag gu 22
<210> 8137
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8137
cacguugacu ccugaguuua gg 22
<210> 8138
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8138
cacuaggugg gcggacauaa ag 22
<210> 8139
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8139
cacuaucugu acagggacgc au 22
<210> 8140
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8140
cacucauaca uacaacgggg ac 22
<210> 8141
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8141
cacugaacaa auacagcaac ca 22
<210> 8142
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8142
cacugauguc cggagagaca gu 22
<210> 8143
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8143
cacugcgccc ggccucaccg ug 22
<210> 8144
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8144
cacugcuuuc cagccugggc aa 22
<210> 8145
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8145
cacugggugg gucaugauuc gg 22
<210> 8146
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8146
cacuggucac ccuuaauauu ua 22
<210> 8147
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8147
cacuguauag aagguuuuug ua 22
<210> 8148
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8148
cacuguccga agccuguucu gc 22
<210> 8149
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8149
cacugucucu ccggacauca gu 22
<210> 8150
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8150
cacuguguac auuuggcauu ug 22
<210> 8151
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8151
cacuguuuuc ugucgugugu gu 22
<210> 8152
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8152
cacuuaauaa auauuaaggg ug 22
<210> 8153
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8153
cacuuccauu cccguggucu cc 22
<210> 8154
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8154
cacuucccag aggcagagcc ug 22
<210> 8155
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8155
cacuucccca aucuugucgu ug 22
<210> 8156
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8156
cacuucuaug caaaugccuc ca 22
<210> 8157
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8157
cacuugcuuc ucugggccug ac 22
<210> 8158
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8158
cacuuucuca guucagaguu gu 22
<210> 8159
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8159
cacuuuggga ggcugagcug ga 22
<210> 8160
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8160
cacuuuuuaa accacuguau ag 22
<210> 8161
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8161
cagaaagaac cugaaguccc gu 22
<210> 8162
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8162
cagaaaggcu uaucacgguu cc 22
<210> 8163
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8163
cagaacaggc uucggacagu gc 22
<210> 8164
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8164
cagaacccuu ccugagaccu cg 22
<210> 8165
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8165
cagaagccac ucauacauac aa 22
<210> 8166
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8166
cagacacagg ugccucacgc cu 22
<210> 8167
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8167
cagacucccg cgugaagaug uc 22
<210> 8168
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8168
cagagaagac caaagcauug cc 22
<210> 8169
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8169
cagagaagca aguggcuuuc aa 22
<210> 8170
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8170
cagagagggg cagguugacc gg 22
<210> 8171
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8171
cagagccuga gucacugguc ac 22
<210> 8172
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8172
cagaggcaau aacccccuac ac 22
<210> 8173
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8173
cagaggcaga gccugaguca cu 22
<210> 8174
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8174
cagaggccau gggcugcuga ug 22
<210> 8175
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8175
cagaguugua cacuguguac au 22
<210> 8176
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8176
cagauagugg ggauuuuuug uu 22
<210> 8177
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8177
cagaucauuu ccgacgccau ga 22
<210> 8178
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8178
cagaugaaga cccuauuuca ga 22
<210> 8179
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8179
cagauggcac caacgggacc cc 22
<210> 8180
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8180
cagaugguca gucuggagga ug 22
<210> 8181
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8181
cagauguuca cgccacguca uc 22
<210> 8182
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8182
cagcaaccag gguuugcaaa aa 22
<210> 8183
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8183
cagcacuuug ggaggcugag cu 22
<210> 8184
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8184
cagcagaugg caccaacggg ac 22
<210> 8185
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8185
cagcagccca uggccucugg cc 22
<210> 8186
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8186
cagccacacc ugggugcagg cc 22
<210> 8187
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8187
cagccagauc auuuccgacg cc 22
<210> 8188
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8188
cagccagguu agccuuugcc cu 22
<210> 8189
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8189
cagcccaugg ccucuggcca gg 22
<210> 8190
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8190
cagccucaaa ugccugagcu ca 22
<210> 8191
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8191
cagccuccgu cagacucccg cg 22
<210> 8192
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8192
cagccucgcc augccuggcc ag 22
<210> 8193
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8193
cagccuggug cccauccucc cg 22
<210> 8194
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8194
cagcugggua cgguggcacg ug 22
<210> 8195
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8195
caggaaaggg auucauggcg uc 22
<210> 8196
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8196
caggaagggu ucugggcagg ga 22
<210> 8197
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8197
caggaaguuu ugaguuucuc uc 22
<210> 8198
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8198
caggacacca gccuggugcc ca 22
<210> 8199
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8199
caggagucaa cguguuuacc uc 22
<210> 8200
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8200
caggaguugg agaccaggcc ug 22
<210> 8201
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8201
caggaugaca ccuccauuuc uc 22
<210> 8202
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8202
caggcaaugc uuuggucuuc uc 22
<210> 8203
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8203
caggcacgug ccaccguacc ca 22
<210> 8204
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8204
caggcacuua auaaauauua ag 22
<210> 8205
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8205
caggcagaug uucacgccac gu 22
<210> 8206
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8206
caggcauggc gaggcugagg ug 22
<210> 8207
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8207
caggcauuug aggcugucgu ga 22
<210> 8208
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8208
caggccacgu guccucacgg cc 22
<210> 8209
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8209
caggccaggg aaagcccgug uc 22
<210> 8210
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8210
caggcccaga gaagcaagug gc 22
<210> 8211
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8211
caggcccggg gggaccagga ug 22
<210> 8212
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8212
caggccugag caacaaagcg ag 22
<210> 8213
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8213
caggccuggu cuccaacucc ug 22
<210> 8214
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8214
caggcgugag gcaccugugu cu 22
<210> 8215
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8215
caggcuacaa aaaccuucua ua 22
<210> 8216
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8216
caggcucugc cucugggaag ug 22
<210> 8217
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8217
caggcuggaa agcaguggca ua 22
<210> 8218
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8218
caggcuggug uccugacagc ca 22
<210> 8219
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8219
caggcuucgg acagugccca ug 22
<210> 8220
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8220
cagggaaagc ccgugucaau ga 22
<210> 8221
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8221
cagggaaccg ugauaagccu uu 22
<210> 8222
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8222
cagggacgca uuuacgugcu cc 22
<210> 8223
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8223
cagggacggg acuccaggca ga 22
<210> 8224
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8224
cagggcaaag gcuaaccugg cu 22
<210> 8225
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8225
cagggccagg gggucccguu gg 22
<210> 8226
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8226
cagggccccg agaauaguca cu 22
<210> 8227
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8227
cagggggucc cguuggugcc au 22
<210> 8228
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8228
cagguguggc ugucaggaca cc 22
<210> 8229
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8229
cagguuagcc uuugcccugu ca 22
<210> 8230
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8230
cagguucuuu cugaaaucgc cg 22
<210> 8231
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8231
cagguugacc gggacuucaa ag 22
<210> 8232
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8232
caguaacacg gcgauuucag aa 22
<210> 8233
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8233
caguaagaca uucaggcuac aa 22
<210> 8234
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8234
caguccaguu cgugcaaaua au 22
<210> 8235
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8235
cagucuggag gaugacgugg cg 22
<210> 8236
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8236
cagucuggau cguuugacgg ga 22
<210> 8237
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8237
cagugacagc cuccgucaga cu 22
<210> 8238
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8238
cagugacuau ucucggggcc cu 22
<210> 8239
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8239
cagugacuca ggcucugccu cu 22
<210> 8240
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8240
cagugcaaaa uaauaacaca aa 22
<210> 8241
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8241
cagugcaaca guaacacggc ga 22
<210> 8242
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8242
cagugcaggg aaccgugaua ag 22
<210> 8243
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8243
cagugcccau gcaauggcuu gg 22
<210> 8244
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8244
cagugguuua aaaagugaca cc 22
<210> 8245
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8245
caguguacaa cucugaacug ag 22
<210> 8246
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8246
cagugucuuu cgaggugggu uu 22
<210> 8247
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8247
caguguuuug ucccugggga ca 22
<210> 8248
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8248
caguucagag uuguacacug ug 22
<210> 8249
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8249
caguucgugc aaauaaucuu ug 22
<210> 8250
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8250
caguucucga uauucacgau ca 22
<210> 8251
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8251
caguuucaac caauauacaa ag 22
<210> 8252
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8252
cauaaagaag aggcauuuca ga 22
<210> 8253
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8253
cauaaagacg acaauggcag uu 22
<210> 8254
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8254
cauaacaaaa aauccccacu au 22
<210> 8255
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8255
cauaaucaua gcucacgaca gc 22
<210> 8256
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8256
cauacaacgg ggacaucauu cu 22
<210> 8257
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8257
cauacauaca acggggacau ca 22
<210> 8258
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8258
cauacccauc aacgacaaga uu 22
<210> 8259
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8259
cauagaagag guaaacacgu ug 22
<210> 8260
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8260
cauagaagug gaagcacuag gu 22
<210> 8261
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8261
cauagcucac gacagccuca aa 22
<210> 8262
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8262
caucaacgac aagauugggg aa 22
<210> 8263
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8263
caucagcagc ccauggccuc ug 22
<210> 8264
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8264
caucagugca acaguaacac gg 22
<210> 8265
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8265
caucauucuc ccaaaaagcg uu 22
<210> 8266
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8266
caucauuugg ugaaugaguu ug 22
<210> 8267
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8267
cauccaccaa ucucuaagcc aa 22
<210> 8268
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8268
caucccaaca cacacgacag aa 22
<210> 8269
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8269
cauccccucc ccuuucaucu uc 22
<210> 8270
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8270
cauccuccca ccucagccuc gc 22
<210> 8271
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8271
cauccucccg accccuaccc ac 22
<210> 8272
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8272
cauccugguc cccccgggcc ug 22
<210> 8273
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8273
caucucccag aagccacuca ua 22
<210> 8274
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8274
caucucuuaa aaaaugaauu ug 22
<210> 8275
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8275
caucugccug gagucccguc cc 22
<210> 8276
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8276
caucugcugu uguguguuga aa 22
<210> 8277
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8277
caucugggag gcagaacagg cu 22
<210> 8278
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8278
caucuucacg cgggagucug ac 22
<210> 8279
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8279
caucuuccau guuugaggau ug 22
<210> 8280
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8280
caugaauccc uuuccuggcu ua 22
<210> 8281
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8281
caugacccac ccagugucuu uc 22
<210> 8282
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8282
caugauucgg gggugacagg gc 22
<210> 8283
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8283
caugcaaugg cuuggguugg ga 22
<210> 8284
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8284
caugcacggu gaggccgggc gc 22
<210> 8285
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8285
caugcauggu gcaucagcag cc 22
<210> 8286
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8286
caugccuggc cagaggccau gg 22
<210> 8287
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8287
cauggaagau gaaaggggag gg 22
<210> 8288
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8288
cauggccucu ggccaggcau gg 22
<210> 8289
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8289
cauggcgagg cugagguggg ag 22
<210> 8290
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8290
cauggcgucg gaaaugaucu gg 22
<210> 8291
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8291
caugggcacu guccgaagcc ug 22
<210> 8292
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8292
caugggcugc ugaugcacca ug 22
<210> 8293
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8293
cauggugcau cagcagccca ug 22
<210> 8294
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8294
cauguuugag gauuguguca cg 22
<210> 8295
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8295
cauguuuuaa acacauaccc au 22
<210> 8296
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8296
cauucaccaa augaugccac uu 22
<210> 8297
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8297
cauucacuuc cccaaucuug uc 22
<210> 8298
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8298
cauucaggcu acaaaaaccu uc 22
<210> 8299
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8299
cauucauuga cacgggcuuu cc 22
<210> 8300
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8300
cauucccgug gucuccuugc ac 22
<210> 8301
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8301
cauucuccca aaaagcguug ca 22
<210> 8302
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8302
cauugacacg ggcuuucccu gg 22
<210> 8303
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8303
cauugcaugg gcacuguccg aa 22
<210> 8304
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8304
cauugccugc cagagcuuug uu 22
<210> 8305
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8305
cauugucguc uuuauguccg cc 22
<210> 8306
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8306
cauuuacgug cuccgaaacc ag 22
<210> 8307
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8307
cauuucagag gcaauaaccc cc 22
<210> 8308
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8308
cauuuccgac gccaugaauc cc 22
<210> 8309
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8309
cauuucucuc caggaaguuu ug 22
<210> 8310
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8310
cauuugaggc ugucgugagc ua 22
<210> 8311
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8311
cauuugcaua gaaguggaag ca 22
<210> 8312
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8312
cauuugguga augaguuugg uc 22
<210> 8313
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8313
cauuuuuuaa gagauggggu cu 22
<210> 8314
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8314
ccaaaaagcg uugcacacag uc 22
<210> 8315
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8315
ccaaaaaguu aaaaaucagc ug 22
<210> 8316
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8316
ccaaaauccc aacccaagcc au 22
<210> 8317
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8317
ccaaaccccu aaacucagga gu 22
<210> 8318
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8318
ccaaacucau ucaccaaaug au 22
<210> 8319
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8319
ccaaagcauu gccugccaga gc 22
<210> 8320
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8320
ccaaaugaug ccacuuccca ga 22
<210> 8321
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8321
ccaaauguac acaguguaca ac 22
<210> 8322
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8322
ccaaauucau uuuuuaagag au 22
<210> 8323
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8323
ccaacacaca cgacagaaaa ca 22
<210> 8324
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8324
ccaacccaag ccauugcaug gg 22
<210> 8325
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8325
ccaacgggac ccccuggccc ug 22
<210> 8326
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8326
ccaacuccug aacucaagug au 22
<210> 8327
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8327
ccaagccauu cacuucccca au 22
<210> 8328
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8328
ccaagccauu gcaugggcac ug 22
<210> 8329
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8329
ccaagguaac cgggugucuc ag 22
<210> 8330
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8330
ccaaucccuu gugacaucuu ca 22
<210> 8331
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8331
ccaaucucua agccaaaccc cu 22
<210> 8332
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8332
ccaaucuugu cguugauggg ua 22
<210> 8333
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8333
ccacaccugg gugcaggcca cg 22
<210> 8334
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8334
ccaccaaucu cuaagccaaa cc 22
<210> 8335
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8335
ccaccacgga uucagccaga uc 22
<210> 8336
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8336
ccacccagug ucuuucgagg ug 22
<210> 8337
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8337
ccaccguacc cagcugauuu uu 22
<210> 8338
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8338
ccaccgugac acaauccuca aa 22
<210> 8339
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8339
ccaccuagug cuuccacuuc ua 22
<210> 8340
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8340
ccaccucagc cucgccaugc cu 22
<210> 8341
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8341
ccaccucgaa agacacuggg ug 22
<210> 8342
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8342
ccacggauuc agccagauca uu 22
<210> 8343
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8343
ccacgggaau ggaagugggu ag 22
<210> 8344
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8344
ccacgucauc cuccagacug ac 22
<210> 8345
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8345
ccacgugucc ucacggccaa gg 22
<210> 8346
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8346
ccacuaucug uacagggacg ca 22
<210> 8347
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8347
ccacucauac auacaacggg ga 22
<210> 8348
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8348
ccacugcgcc cggccucacc gu 22
<210> 8349
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8349
ccacuguaua gaagguuuuu gu 22
<210> 8350
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8350
ccacuuccau ucccgugguc uc 22
<210> 8351
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8351
ccacuuccca gaggcagagc cu 22
<210> 8352
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8352
ccacuucuau gcaaaugccu cc 22
<210> 8353
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8353
ccacuugcuu cucugggccu ga 22
<210> 8354
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8354
ccagaaaggc uuaucacggu uc 22
<210> 8355
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8355
ccagaacccu uccugagacc uc 22
<210> 8356
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8356
ccagaagcca cucauacaua ca 22
<210> 8357
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8357
ccagacacag gugccucacg cc 22
<210> 8358
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8358
ccagagaagc aaguggcuuu ca 22
<210> 8359
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8359
ccagaggcag agccugaguc ac 22
<210> 8360
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8360
ccagaggcca ugggcugcug au 22
<210> 8361
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8361
ccagaucauu uccgacgcca ug 22
<210> 8362
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8362
ccagcacuuu gggaggcuga gc 22
<210> 8363
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8363
ccagccuggu gcccauccuc cc 22
<210> 8364
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8364
ccaggaaagg gauucauggc gu 22
<210> 8365
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8365
ccaggaaguu uugaguuucu cu 22
<210> 8366
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8366
ccaggaugac accuccauuu cu 22
<210> 8367
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8367
ccaggcagau guucacgcca cg 22
<210> 8368
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8368
ccaggcaugg cgaggcugag gu 22
<210> 8369
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8369
ccaggccagg gaaagcccgu gu 22
<210> 8370
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8370
ccaggccuga gcaacaaagc ga 22
<210> 8371
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8371
ccaggcugga aagcaguggc au 22
<210> 8372
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8372
ccaggcuggu guccugacag cc 22
<210> 8373
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8373
ccagggaaag cccgugucaa ug 22
<210> 8374
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8374
ccaggggguc ccguuggugc ca 22
<210> 8375
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8375
ccaggugugg cugucaggac ac 22
<210> 8376
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8376
ccagguuagc cuuugcccug uc 22
<210> 8377
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8377
ccagucugga ucguuugacg gg 22
<210> 8378
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8378
ccagugacuc aggcucugcc uc 22
<210> 8379
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8379
ccagugcagg gaaccgugau aa 22
<210> 8380
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8380
ccagugucuu ucgagguggg uu 22
<210> 8381
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8381
ccaguucgug caaauaaucu uu 22
<210> 8382
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8382
ccaucaacga caagauuggg ga 22
<210> 8383
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8383
ccaucccaac acacacgaca ga 22
<210> 8384
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8384
ccauccuccc accucagccu cg 22
<210> 8385
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8385
ccauccuccc gaccccuacc ca 22
<210> 8386
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8386
ccaucuccca gaagccacuc au 22
<210> 8387
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8387
ccaucucuua aaaaaugaau uu 22
<210> 8388
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8388
ccaucugcug uuguguguug aa 22
<210> 8389
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8389
ccaugaaucc cuuuccuggc uu 22
<210> 8390
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8390
ccaugcaaug gcuuggguug gg 22
<210> 8391
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8391
ccaugcaugg ugcaucagca gc 22
<210> 8392
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8392
ccaugccugg ccagaggcca ug 22
<210> 8393
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8393
ccauggccuc uggccaggca ug 22
<210> 8394
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8394
ccaugggcug cugaugcacc au 22
<210> 8395
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8395
ccauguuuga ggauuguguc ac 22
<210> 8396
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8396
ccauucacuu ccccaaucuu gu 22
<210> 8397
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8397
ccauucccgu ggucuccuug ca 22
<210> 8398
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8398
ccauugcaug ggcacugucc ga 22
<210> 8399
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8399
ccauugucgu cuuuaugucc gc 22
<210> 8400
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8400
ccauuucucu ccaggaaguu uu 22
<210> 8401
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8401
cccaaaaagc guugcacaca gu 22
<210> 8402
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8402
cccaacacac acgacagaaa ac 22
<210> 8403
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8403
cccaacccaa gccauugcau gg 22
<210> 8404
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8404
cccaagccau ugcaugggca cu 22
<210> 8405
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8405
cccaaucuug ucguugaugg gu 22
<210> 8406
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8406
cccacccagu gucuuucgag gu 22
<210> 8407
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8407
cccaccuagu gcuuccacuu cu 22
<210> 8408
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8408
cccaccucag ccucgccaug cc 22
<210> 8409
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8409
cccaccucga aagacacugg gu 22
<210> 8410
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8410
cccacuaucu guacagggac gc 22
<210> 8411
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8411
cccacuucca uucccguggu cu 22
<210> 8412
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8412
cccagaaccc uuccugagac cu 22
<210> 8413
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8413
cccagaagcc acucauacau ac 22
<210> 8414
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8414
cccagagaag caaguggcuu uc 22
<210> 8415
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8415
cccagaggca gagccugagu ca 22
<210> 8416
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8416
cccagcugau uuuuaacuuu uu 22
<210> 8417
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8417
cccaggccag ggaaagcccg ug 22
<210> 8418
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8418
cccaggcugg aaagcagugg ca 22
<210> 8419
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8419
cccaggugug gcugucagga ca 22
<210> 8420
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8420
cccagugcag ggaaccguga ua 22
<210> 8421
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8421
cccagugucu uucgaggugg gu 22
<210> 8422
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8422
cccaucaacg acaagauugg gg 22
<210> 8423
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8423
cccaucccaa cacacacgac ag 22
<210> 8424
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8424
cccauccucc cgaccccuac cc 22
<210> 8425
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8425
cccaucuccc agaagccacu ca 22
<210> 8426
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8426
cccaucucua caaaaaccaa aa 22
<210> 8427
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8427
cccaucucuu aaaaaaugaa uu 22
<210> 8428
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8428
cccaugcaau ggcuuggguu gg 22
<210> 8429
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8429
cccauggccu cuggccaggc au 22
<210> 8430
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8430
ccccaaucuu gucguugaug gg 22
<210> 8431
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8431
ccccacuauc uguacaggga cg 22
<210> 8432
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8432
ccccagggac aaaacacugu gu 22
<210> 8433
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8433
ccccagugca gggaaccgug au 22
<210> 8434
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8434
ccccaucucu uaaaaaauga au 22
<210> 8435
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8435
cccccagugc agggaaccgu ga 22
<210> 8436
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8436
ccccccagug cagggaaccg ug 22
<210> 8437
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8437
ccccccgggc cuguuucucu ua 22
<210> 8438
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8438
cccccgaauc augacccacc ca 22
<210> 8439
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8439
cccccgggcc uguuucucuu au 22
<210> 8440
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8440
cccccuacac agggccccga ga 22
<210> 8441
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8441
cccccuggcc cugccucauc ca 22
<210> 8442
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8442
ccccgaauca ugacccaccc ag 22
<210> 8443
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8443
ccccgagaau agucacugaa ca 22
<210> 8444
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8444
ccccggcauu cauugacacg gg 22
<210> 8445
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8445
ccccgggccu guuucucuua uc 22
<210> 8446
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8446
ccccguugua uguaugagug gc 22
<210> 8447
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8447
ccccuaaacu caggagucaa cg 22
<210> 8448
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8448
ccccuacaca gggccccgag aa 22
<210> 8449
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8449
ccccuaccca cuuccauucc cg 22
<210> 8450
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8450
ccccuccccu uucaucuucc au 22
<210> 8451
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8451
ccccucucug uccccggcau uc 22
<210> 8452
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8452
ccccuggccc ugccucaucc ac 22
<210> 8453
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8453
ccccuuucau cuuccauguu ug 22
<210> 8454
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8454
cccgaaucau gacccaccca gu 22
<210> 8455
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8455
cccgaccccu acccacuucc au 22
<210> 8456
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8456
cccgagaaua gucacugaac aa 22
<210> 8457
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8457
cccgcgugaa gaugucacaa gg 22
<210> 8458
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8458
cccggcauuc auugacacgg gc 22
<210> 8459
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8459
cccggccuca ccgugcaugu uu 22
<210> 8460
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8460
cccgggccug uuucucuuau cc 22
<210> 8461
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8461
cccgggggga ccaggaugac ac 22
<210> 8462
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8462
cccggucaac cugccccucu cu 22
<210> 8463
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8463
cccgguuacc uuggccguga gg 22
<210> 8464
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8464
cccgucaaac gauccagacu gg 22
<210> 8465
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8465
cccgucccug cccagaaccc uu 22
<210> 8466
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8466
cccguggucu ccuugcacuu uc 22
<210> 8467
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8467
cccgugucaa ugaaugccgg gg 22
<210> 8468
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8468
cccguuggug ccaucugcug uu 22
<210> 8469
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8469
cccguuguau guaugagugg cu 22
<210> 8470
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8470
cccuaaacuc aggagucaac gu 22
<210> 8471
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8471
cccuacacag ggccccgaga au 22
<210> 8472
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8472
cccuacccac uuccauuccc gu 22
<210> 8473
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8473
cccuccccuu ucaucuucca ug 22
<210> 8474
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8474
cccucucugu ccccggcauu ca 22
<210> 8475
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8475
cccugcccag aacccuuccu ga 22
<210> 8476
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8476
cccugccuca uccaccaauc uc 22
<210> 8477
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8477
cccuggcccu gccucaucca cc 22
<210> 8478
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8478
cccuggccug ggaucccauc cc 22
<210> 8479
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8479
cccuggggac aauugccaau cc 22
<210> 8480
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8480
cccugguugc uguauuuguu ca 22
<210> 8481
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8481
cccuguacag auagugggga uu 22
<210> 8482
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8482
cccugucacc cccgaaucau ga 22
<210> 8483
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8483
cccuguguag gggguuauug cc 22
<210> 8484
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8484
cccuuaauau uuauuaagug cc 22
<210> 8485
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8485
cccuuccuga gaccucgccg gc 22
<210> 8486
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8486
cccuugugac aucuucacgc gg 22
<210> 8487
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8487
cccuuucauc uuccauguuu ga 22
<210> 8488
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8488
cccuuuccug gcuuaaggaa gg 22
<210> 8489
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8489
ccgaaaccag aaaggcuuau ca 22
<210> 8490
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8490
ccgaagccug uucugccucc ca 22
<210> 8491
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8491
ccgaaucaug acccacccag ug 22
<210> 8492
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8492
ccgaccccua cccacuucca uu 22
<210> 8493
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8493
ccgacgccau gaaucccuuu cc 22
<210> 8494
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8494
ccgagaauag ucacugaaca aa 22
<210> 8495
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8495
ccgagaccaa acucauucac ca 22
<210> 8496
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8496
ccgcccaccu agugcuucca cu 22
<210> 8497
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8497
ccgcgugaag augucacaag gg 22
<210> 8498
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8498
ccggacauca gugcaacagu aa 22
<210> 8499
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8499
ccggagagac agugacagcc uc 22
<210> 8500
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8500
ccggcauuca uugacacggg cu 22
<210> 8501
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8501
ccggccucac cgugcauguu uu 22
<210> 8502
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8502
ccggccuugu uuuauucaaa ga 22
<210> 8503
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8503
ccggcgaggu cucaggaagg gu 22
<210> 8504
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8504
ccgggacuuc aaagccguga uc 22
<210> 8505
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8505
ccgggccugu uucucuuauc cu 22
<210> 8506
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8506
ccggggacag agaggggcag gu 22
<210> 8507
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8507
ccggggggac caggaugaca cc 22
<210> 8508
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8508
ccgggugucu caggcacuua au 22
<210> 8509
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8509
ccggucaacc ugccccucuc ug 22
<210> 8510
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8510
ccgguuaccu uggccgugag ga 22
<210> 8511
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8511
ccguacccag cugauuuuua ac 22
<210> 8512
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8512
ccgucaaacg auccagacug ga 22
<210> 8513
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8513
ccgucagacu cccgcgugaa ga 22
<210> 8514
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8514
ccgucccugc ccagaacccu uc 22
<210> 8515
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8515
ccgugacaca auccucaaac au 22
<210> 8516
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8516
ccgugaggac acguggccug ca 22
<210> 8517
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8517
ccgugauaag ccuuucuggu uu 22
<210> 8518
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8518
ccgugaucgu gaauaucgag aa 22
<210> 8519
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8519
ccgugcaugu uuuaaacaca ua 22
<210> 8520
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8520
ccguggucuc cuugcacuuu cu 22
<210> 8521
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8521
ccgugguggc accgagacca aa 22
<210> 8522
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8522
ccgugucaau gaaugccggg ga 22
<210> 8523
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8523
ccguguuacu guugcacuga ug 22
<210> 8524
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8524
ccguuggugc caucugcugu ug 22
<210> 8525
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8525
ccguuguaug uaugaguggc uu 22
<210> 8526
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8526
ccuaaacuca ggagucaacg ug 22
<210> 8527
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8527
ccuacacagg gccccgagaa ua 22
<210> 8528
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8528
ccuacccacu uccauucccg ug 22
<210> 8529
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8529
ccuagugcuu ccacuucuau gc 22
<210> 8530
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8530
ccucaaacau ggaagaugaa ag 22
<210> 8531
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8531
ccucaaaugc cugagcucaa ac 22
<210> 8532
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8532
ccucaccgug cauguuuuaa ac 22
<210> 8533
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8533
ccucacggcc aagguaaccg gg 22
<210> 8534
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8534
ccucagccuc gccaugccug gc 22
<210> 8535
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8535
ccucauccac caaucucuaa gc 22
<210> 8536
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8536
ccuccaagcc auucacuucc cc 22
<210> 8537
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8537
ccuccagucu ggaucguuug ac 22
<210> 8538
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8538
ccuccauuuc ucuccaggaa gu 22
<210> 8539
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8539
ccucccaccu cagccucgcc au 22
<210> 8540
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8540
ccuccccuuu caucuuccau gu 22
<210> 8541
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8541
ccucccgacc ccuacccacu uc 22
<210> 8542
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8542
ccuccgucag acucccgcgu ga 22
<210> 8543
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8543
ccucgaaaga cacugggugg gu 22
<210> 8544
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8544
ccucgccaug ccuggccaga gg 22
<210> 8545
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8545
ccucgccggc cuuguuuuau uc 22
<210> 8546
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8546
ccucgugaag gauaagagaa ac 22
<210> 8547
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8547
ccucucuguc cccggcauuc au 22
<210> 8548
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8548
ccucugaaau gccucuucuu ua 22
<210> 8549
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8549
ccucuggcca ggcauggcga gg 22
<210> 8550
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8550
ccucugggaa guggcaucau uu 22
<210> 8551
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8551
ccucuucuau gcaagccuug cu 22
<210> 8552
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8552
ccugaacuca agugauccag cu 22
<210> 8553
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8553
ccugaagucc cgucaaacga uc 22
<210> 8554
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8554
ccugaauguc uuacugugau ca 22
<210> 8555
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8555
ccugacagcc acaccugggu gc 22
<210> 8556
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8556
ccugacaucc ccuccccuuu ca 22
<210> 8557
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8557
ccugagacac ccgguuaccu ug 22
<210> 8558
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8558
ccugagaccu cgccggccuu gu 22
<210> 8559
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8559
ccugagcaac aaagcgagau cc 22
<210> 8560
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8560
ccugagucac uggucacccu ua 22
<210> 8561
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8561
ccugaguuua gggguuuggc uu 22
<210> 8562
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8562
ccugcaccca gguguggcug uc 22
<210> 8563
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8563
ccugccagag cuuuguuuua ua 22
<210> 8564
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8564
ccugcccaga acccuuccug ag 22
<210> 8565
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8565
ccugccccuc ucuguccccg gc 22
<210> 8566
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8566
ccugccucau ccaccaaucu cu 22
<210> 8567
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8567
ccuggagaga aauggaggug uc 22
<210> 8568
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8568
ccuggagucc cgucccugcc ca 22
<210> 8569
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8569
ccuggccaga ggccaugggc ug 22
<210> 8570
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8570
ccuggcccug ccucauccac ca 22
<210> 8571
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8571
ccuggccugg gaucccaucc ca 22
<210> 8572
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8572
ccuggcuguc uagcaaggcu ug 22
<210> 8573
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8573
ccuggcuuaa ggaagguaca aa 22
<210> 8574
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8574
ccugggaucc caucccaaca ca 22
<210> 8575
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8575
ccuggggaca auugccaauc cc 22
<210> 8576
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8576
ccugggugca ggccacgugu cc 22
<210> 8577
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8577
ccuggucccc ccgggccugu uu 22
<210> 8578
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8578
ccuggugccc auccucccga cc 22
<210> 8579
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8579
ccugguugcu guauuuguuc ag 22
<210> 8580
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8580
ccuguacaga uaguggggau uu 22
<210> 8581
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8581
ccugucaccc ccgaaucaug ac 22
<210> 8582
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8582
ccuguguagg ggguuauugc cu 22
<210> 8583
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8583
ccugugucug gccaaauuca uu 22
<210> 8584
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8584
ccuguucugc cucccagaug aa 22
<210> 8585
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8585
ccuguuucuc uuauccuuca cg 22
<210> 8586
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8586
ccuuaagcca ggaaagggau uc 22
<210> 8587
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8587
ccuuaauauu uauuaagugc cu 22
<210> 8588
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8588
ccuucacgag gaaaggaaga aa 22
<210> 8589
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8589
ccuuccugag accucgccgg cc 22
<210> 8590
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8590
ccuuccuuaa gccaggaaag gg 22
<210> 8591
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8591
ccuucuauac agugguuuaa aa 22
<210> 8592
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8592
ccuugcacuu ucucaguuca ga 22
<210> 8593
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8593
ccuugcuaga cagccagguu ag 22
<210> 8594
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8594
ccuuggccgu gaggacacgu gg 22
<210> 8595
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8595
ccuugugaca ucuucacgcg gg 22
<210> 8596
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8596
ccuuguuuua uucaaagaca ga 22
<210> 8597
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8597
ccuuucaucu uccauguuug ag 22
<210> 8598
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8598
ccuuuccucg ugaaggauaa ga 22
<210> 8599
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8599
ccuuuccugg cuuaaggaag gu 22
<210> 8600
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8600
ccuuucuggu uucggagcac gu 22
<210> 8601
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8601
ccuuugcccu gucacccccg aa 22
<210> 8602
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8602
cgaaaccaga aaggcuuauc ac 22
<210> 8603
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8603
cgaaagacac uggguggguc au 22
<210> 8604
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8604
cgaacuggac ugugugcaac gc 22
<210> 8605
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8605
cgaaucauga cccacccagu gu 22
<210> 8606
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8606
cgacaagauu ggggaaguga au 22
<210> 8607
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8607
cgacaauggc aguucucgau au 22
<210> 8608
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8608
cgacagaaaa cagugcaaaa ua 22
<210> 8609
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8609
cgacagccuc aaaugccuga gc 22
<210> 8610
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8610
cgaccccuac ccacuuccau uc 22
<210> 8611
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8611
cgacgccaug aaucccuuuc cu 22
<210> 8612
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8612
cgagaacugc cauugucguc uu 22
<210> 8613
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8613
cgagaauagu cacugaacaa au 22
<210> 8614
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8614
cgagaccaaa cucauucacc aa 22
<210> 8615
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8615
cgagauccca ucucuacaaa aa 22
<210> 8616
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8616
cgaggaaagg aagaaaccaa aa 22
<210> 8617
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8617
cgaggucuca ggaaggguuc ug 22
<210> 8618
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8618
cgaggugggu uuguaccuuc cu 22
<210> 8619
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8619
cgauauucac gaucacggcu uu 22
<210> 8620
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8620
cgaucacggc uuugaagucc cg 22
<210> 8621
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8621
cgauccagac uggaggauuu au 22
<210> 8622
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8622
cgauuucaga aagaaccuga ag 22
<210> 8623
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8623
cgcauuuacg ugcuccgaaa cc 22
<210> 8624
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8624
cgccacguca uccuccagac ug 22
<210> 8625
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8625
cgccaugaau cccuuuccug gc 22
<210> 8626
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8626
cgccaugccu ggccagaggc ca 22
<210> 8627
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8627
cgcccaccua gugcuuccac uu 22
<210> 8628
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8628
cgcccggccu caccgugcau gu 22
<210> 8629
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8629
cgccggccuu guuuuauuca aa 22
<210> 8630
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8630
cgccguguua cuguugcacu ga 22
<210> 8631
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8631
cgcgggaguc ugacggaggc ug 22
<210> 8632
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8632
cgcgugaaga ugucacaagg ga 22
<210> 8633
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8633
cgcuuuguug cucaggccug gu 22
<210> 8634
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8634
cgcuuuuugg gagaaugaug uc 22
<210> 8635
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8635
cggaaaugau cuggcugaau cc 22
<210> 8636
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8636
cggacagugc ccaugcaaug gc 22
<210> 8637
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8637
cggacauaaa gacgacaaug gc 22
<210> 8638
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8638
cggacaucag ugcaacagua ac 22
<210> 8639
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8639
cggagagaca gugacagccu cc 22
<210> 8640
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8640
cggagcacgu aaaugcgucc cu 22
<210> 8641
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8641
cggaggcugu cacugucucu cc 22
<210> 8642
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8642
cggauucagc cagaucauuu cc 22
<210> 8643
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8643
cggcauucau ugacacgggc uu 22
<210> 8644
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8644
cggccaaggu aaccgggugu cu 22
<210> 8645
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8645
cggccucacc gugcauguuu ua 22
<210> 8646
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8646
cggccuuguu uuauucaaag ac 22
<210> 8647
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8647
cggcgagguc ucaggaaggg uu 22
<210> 8648
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8648
cggcgauuuc agaaagaacc ug 22
<210> 8649
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8649
cggcuuugaa gucccgguca ac 22
<210> 8650
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8650
cgggaaugga aguggguagg gg 22
<210> 8651
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8651
cgggaccccc uggcccugcc uc 22
<210> 8652
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8652
cgggacucca ggcagauguu ca 22
<210> 8653
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8653
cgggacuuca aagccgugau cg 22
<210> 8654
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8654
cgggacuuca gguucuuucu ga 22
<210> 8655
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8655
cgggaggaug ggcaccaggc ug 22
<210> 8656
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8656
cgggagucug acggaggcug uc 22
<210> 8657
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8657
cgggccuguu ucucuuaucc uu 22
<210> 8658
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8658
cgggcuuucc cuggccuggg au 22
<210> 8659
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8659
cggggacaga gaggggcagg uu 22
<210> 8660
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8660
cggggacauc auucucccaa aa 22
<210> 8661
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8661
cggggcccug uguagggggu ua 22
<210> 8662
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8662
cggggggacc aggaugacac cu 22
<210> 8663
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8663
cgggggugac agggcaaagg cu 22
<210> 8664
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8664
cgggugucuc aggcacuuaa ua 22
<210> 8665
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8665
cggucaaccu gccccucucu gu 22
<210> 8666
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8666
cggugaggcc gggcgcagug gc 22
<210> 8667
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8667
cggugccacc acggauucag cc 22
<210> 8668
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8668
cgguggagag aaacucaaaa cu 22
<210> 8669
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8669
cgguuaccuu ggccgugagg ac 22
<210> 8670
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8670
cguaaaugcg ucccuguaca ga 22
<210> 8671
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8671
cguacccagc ugauuuuuaa cu 22
<210> 8672
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8672
cgucaaacga uccagacugg ag 22
<210> 8673
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8673
cgucagacuc ccgcgugaag au 22
<210> 8674
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8674
cgucauccuc cagacugacc au 22
<210> 8675
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8675
cgucccugcc cagaacccuu cc 22
<210> 8676
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8676
cgucccugua cagauagugg gg 22
<210> 8677
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8677
cgucggaaau gaucuggcug aa 22
<210> 8678
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8678
cgucuuuaug uccgcccacc ua 22
<210> 8679
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8679
cgugaacauc ugccuggagu cc 22
<210> 8680
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8680
cgugaagaug ucacaaggga uu 22
<210> 8681
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8681
cgugaaggau aagagaaaca gg 22
<210> 8682
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8682
cgugaauauc gagaacugcc au 22
<210> 8683
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8683
cgugacacaa uccucaaaca ug 22
<210> 8684
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8684
cgugagccac ugcgcccggc cu 22
<210> 8685
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8685
cgugagcuau gauuaugcca cu 22
<210> 8686
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8686
cgugaggaca cguggccugc ac 22
<210> 8687
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8687
cgugaggcac cugugucugg cc 22
<210> 8688
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8688
cgugauaagc cuuucugguu uc 22
<210> 8689
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8689
cgugaucgug aauaucgaga ac 22
<210> 8690
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8690
cgugcauguu uuaaacacau ac 22
<210> 8691
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8691
cgugccaccg uacccagcug au 22
<210> 8692
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8692
cgugcuccga aaccagaaag gc 22
<210> 8693
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8693
cguggccugc acccaggugu gg 22
<210> 8694
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8694
cguggcguga acaucugccu gg 22
<210> 8695
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8695
cguggucucc uugcacuuuc uc 22
<210> 8696
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8696
cgugguggca ccgagaccaa ac 22
<210> 8697
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8697
cgugucaaug aaugccgggg ac 22
<210> 8698
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8698
cguguccuca cggccaaggu aa 22
<210> 8699
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8699
cguguguguu gggaugggau cc 22
<210> 8700
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8700
cguguuacug uugcacugau gu 22
<210> 8701
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8701
cguguuuacc ucuucuaugc aa 22
<210> 8702
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8702
cguugacucc ugaguuuagg gg 22
<210> 8703
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8703
cguugauggg uauguguuua aa 22
<210> 8704
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8704
cguugcacac aguccaguuc gu 22
<210> 8705
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8705
cguuggugcc aucugcuguu gu 22
<210> 8706
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8706
cguuguaugu augaguggcu uc 22
<210> 8707
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8707
cguuugacgg gacuucaggu uc 22
<210> 8708
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8708
cuaaacucag gagucaacgu gu 22
<210> 8709
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8709
cuaaccuggc ugucuagcaa gg 22
<210> 8710
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8710
cuaagccaaa ccccuaaacu ca 22
<210> 8711
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8711
cuacaaaaac cuucuauaca gu 22
<210> 8712
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8712
cuacacaggg ccccgagaau ag 22
<210> 8713
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8713
cuacccacuu ccauucccgu gg 22
<210> 8714
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8714
cuagacagcc agguuagccu uu 22
<210> 8715
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8715
cuagcaaggc uugcauagaa ga 22
<210> 8716
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8716
cuaggugggc ggacauaaag ac 22
<210> 8717
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8717
cuagugcuuc cacuucuaug ca 22
<210> 8718
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8718
cuauacagug guuuaaaaag ug 22
<210> 8719
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8719
cuaucuguac agggacgcau uu 22
<210> 8720
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8720
cuaugauuau gccacugcuu uc 22
<210> 8721
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8721
cuaugcaaau gccuccaagc ca 22
<210> 8722
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8722
cuaugcaagc cuugcuagac ag 22
<210> 8723
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8723
cuauucucgg ggcccugugu ag 22
<210> 8724
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8724
cuauuuauuu uugcaaaccc ug 22
<210> 8725
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8725
cucaaaacuu ccuggagaga aa 22
<210> 8726
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8726
cucaaacaug gaagaugaaa gg 22
<210> 8727
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8727
cucaaaugcc ugagcucaaa cc 22
<210> 8728
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8728
cucaagugau ccagcucagc cu 22
<210> 8729
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8729
cucaccgugc auguuuuaaa ca 22
<210> 8730
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8730
cucacgacag ccucaaaugc cu 22
<210> 8731
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8731
cucacggcca agguaaccgg gu 22
<210> 8732
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8732
cucagccucg ccaugccugg cc 22
<210> 8733
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8733
cucaggaagg guucugggca gg 22
<210> 8734
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8734
cucaggaguc aacguguuua cc 22
<210> 8735
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8735
cucaggcacu uaauaaauau ua 22
<210> 8736
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8736
cucaggcauu ugaggcuguc gu 22
<210> 8737
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8737
cucaggcucu gccucuggga ag 22
<210> 8738
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8738
cucaguucag aguuguacac ug 22
<210> 8739
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8739
cucauacaua caacggggac au 22
<210> 8740
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8740
cucauccacc aaucucuaag cc 22
<210> 8741
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8741
cucauucacc aaaugaugcc ac 22
<210> 8742
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8742
cuccaacucc ugaacucaag ug 22
<210> 8743
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8743
cuccaagcca uucacuuccc ca 22
<210> 8744
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8744
cuccaccgug acacaauccu ca 22
<210> 8745
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8745
cuccaggaag uuuugaguuu cu 22
<210> 8746
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8746
cuccaggcag auguucacgc ca 22
<210> 8747
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8747
cuccagucug gaucguuuga cg 22
<210> 8748
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8748
cuccauuucu cuccaggaag uu 22
<210> 8749
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8749
cucccaaaaa gcguugcaca ca 22
<210> 8750
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8750
cucccaccuc agccucgcca ug 22
<210> 8751
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8751
cucccagaag ccacucauac au 22
<210> 8752
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8752
cuccccuuuc aucuuccaug uu 22
<210> 8753
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8753
cucccgaccc cuacccacuu cc 22
<210> 8754
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8754
cucccgcgug aagaugucac aa 22
<210> 8755
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8755
cuccgaaacc agaaaggcuu au 22
<210> 8756
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8756
cuccggacau cagugcaaca gu 22
<210> 8757
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8757
cuccgucaga cucccgcgug aa 22
<210> 8758
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8758
cuccugaacu caagugaucc ag 22
<210> 8759
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8759
cuccugaguu uagggguuug gc 22
<210> 8760
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8760
cuccuugcac uuucucaguu ca 22
<210> 8761
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8761
cucgaaagac acuggguggg uc 22
<210> 8762
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8762
cucgauauuc acgaucacgg cu 22
<210> 8763
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8763
cucgaucaug gcucacugca ac 22
<210> 8764
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8764
cucgccaugc cuggccagag gc 22
<210> 8765
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8765
cucgccggcc uuguuuuauu ca 22
<210> 8766
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8766
cucgcuuugu ugcucaggcc ug 22
<210> 8767
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8767
cucggggccc uguguagggg gu 22
<210> 8768
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8768
cucggugcca ccacggauuc ag 22
<210> 8769
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8769
cucgugaagg auaagagaaa ca 22
<210> 8770
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8770
cucuaagcca aaccccuaaa cu 22
<210> 8771
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8771
cucuccaccg ugacacaauc cu 22
<210> 8772
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8772
cucuccagga aguuuugagu uu 22
<210> 8773
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8773
cucuccggac aucagugcaa ca 22
<210> 8774
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8774
cucucugucc ccggcauuca uu 22
<210> 8775
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8775
cucugaaaug ccucuucuuu au 22
<210> 8776
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8776
cucugaacug agaaagugca ag 22
<210> 8777
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8777
cucugccucu gggaaguggc au 22
<210> 8778
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8778
cucuggcagg caaugcuuug gu 22
<210> 8779
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8779
cucuggccag gcauggcgag gc 22
<210> 8780
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8780
cucugggaag uggcaucauu ug 22
<210> 8781
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8781
cucugggccu gacauccccu cc 22
<210> 8782
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8782
cucugucccc ggcauucauu ga 22
<210> 8783
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8783
cucugucuuu gaauaaaaca ag 22
<210> 8784
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8784
cucuuaaaaa augaauuugg cc 22
<210> 8785
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8785
cucuuauccu ucacgaggaa ag 22
<210> 8786
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8786
cucuucuaug caagccuugc ua 22
<210> 8787
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8787
cugaaauagg gucuucaucu gu 22
<210> 8788
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8788
cugaaaucgc cguguuacug uu 22
<210> 8789
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8789
cugaaaugcc ucuucuuuau gu 22
<210> 8790
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8790
cugaacaaau acagcaacca gg 22
<210> 8791
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8791
cugaacucaa gugauccagc uc 22
<210> 8792
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8792
cugaacugag aaagugcaag ga 22
<210> 8793
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8793
cugaaguccc gucaaacgau cc 22
<210> 8794
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8794
cugaauccgu gguggcaccg ag 22
<210> 8795
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8795
cugacagcca caccugggug ca 22
<210> 8796
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8796
cugacauccc cuccccuuuc au 22
<210> 8797
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8797
cugacggagg cugucacugu cu 22
<210> 8798
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8798
cugagaaagu gcaaggagac ca 22
<210> 8799
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8799
cugagacacc cgguuaccuu gg 22
<210> 8800
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8800
cugagaccuc gccggccuug uu 22
<210> 8801
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8801
cugagcaaca aagcgagauc cc 22
<210> 8802
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8802
cugagcugga ucacuugagu uc 22
<210> 8803
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8803
cugagucacu ggucacccuu aa 22
<210> 8804
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8804
cugaguuuag ggguuuggcu ua 22
<210> 8805
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8805
cugauguccg gagagacagu ga 22
<210> 8806
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8806
cugcacccag guguggcugu ca 22
<210> 8807
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8807
cugccauugu cgucuuuaug uc 22
<210> 8808
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8808
cugcccagaa cccuuccuga ga 22
<210> 8809
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8809
cugccccucu cuguccccgg ca 22
<210> 8810
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8810
cugccucauc caccaaucuc ua 22
<210> 8811
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8811
cugccuccca gaugaauaaa ua 22
<210> 8812
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8812
cugccucugg gaaguggcau ca 22
<210> 8813
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8813
cugccuggag ucccgucccu gc 22
<210> 8814
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8814
cugcgcccgg ccucaccgug ca 22
<210> 8815
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8815
cugcuguugu guguugaaag cc 22
<210> 8816
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8816
cugcuuucca gccugggcaa ca 22
<210> 8817
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8817
cuggaaagca guggcauaau ca 22
<210> 8818
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8818
cuggacugug ugcaacgcuu uu 22
<210> 8819
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8819
cuggagagaa auggaggugu ca 22
<210> 8820
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8820
cuggaggaug acguggcgug aa 22
<210> 8821
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8821
cuggaguccc gucccugccc ag 22
<210> 8822
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8822
cuggaucacu ugaguucagg ag 22
<210> 8823
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8823
cuggaucguu ugacgggacu uc 22
<210> 8824
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8824
cuggcaggca augcuuuggu cu 22
<210> 8825
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8825
cuggccaaau ucauuuuuua ag 22
<210> 8826
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8826
cuggccagag gccaugggcu gc 22
<210> 8827
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8827
cuggccaggc auggcgaggc ug 22
<210> 8828
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8828
cuggcccugc cucauccacc aa 22
<210> 8829
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8829
cuggccuggg aucccauccc aa 22
<210> 8830
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8830
cuggcugaau ccgugguggc ac 22
<210> 8831
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8831
cuggcugucu agcaaggcuu gc 22
<210> 8832
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8832
cuggcuuaag gaagguacaa ac 22
<210> 8833
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8833
cugggaagug gcaucauuug gu 22
<210> 8834
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8834
cugggagaug ggugucacuu uu 22
<210> 8835
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8835
cugggaggca gaacaggcuu cg 22
<210> 8836
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8836
cugggauccc aucccaacac ac 22
<210> 8837
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8837
cugggauuac aggcgugagg ca 22
<210> 8838
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8838
cugggcaggg acgggacucc ag 22
<210> 8839
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8839
cugggccuga cauccccucc cc 22
<210> 8840
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8840
cuggggacaa uugccaaucc cu 22
<210> 8841
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8841
cuggguacgg uggcacgugc cu 22
<210> 8842
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8842
cugggugcag gccacguguc cu 22
<210> 8843
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8843
cugggugggu caugauucgg gg 22
<210> 8844
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8844
cuggucaccc uuaauauuua uu 22
<210> 8845
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8845
cugguccccc cgggccuguu uc 22
<210> 8846
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8846
cuggugccca uccucccgac cc 22
<210> 8847
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8847
cugguguccu gacagccaca cc 22
<210> 8848
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8848
cugguugcug uauuuguuca gu 22
<210> 8849
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8849
cugguuucgg agcacguaaa ug 22
<210> 8850
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8850
cuguacagau aguggggauu uu 22
<210> 8851
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8851
cuguacaggg acgcauuuac gu 22
<210> 8852
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8852
cuguauagaa gguuuuugua gc 22
<210> 8853
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8853
cuguauuugu ucagugacua uu 22
<210> 8854
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8854
cugucacccc cgaaucauga cc 22
<210> 8855
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8855
cugucacugu cucuccggac au 22
<210> 8856
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8856
cugucaggac accagccugg ug 22
<210> 8857
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8857
cuguccccgg cauucauuga ca 22
<210> 8858
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8858
cuguccgaag ccuguucugc cu 22
<210> 8859
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8859
cugucgugag cuaugauuau gc 22
<210> 8860
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8860
cugucgugug uguugggaug gg 22
<210> 8861
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8861
cugucuagca aggcuugcau ag 22
<210> 8862
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8862
cugucucucc ggacaucagu gc 22
<210> 8863
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8863
cugucuuuga auaaaacaag gc 22
<210> 8864
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8864
cuguguacau uuggcauuug ug 22
<210> 8865
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8865
cuguguaggg gguuauugcc uc 22
<210> 8866
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8866
cugugucugg ccaaauucau uu 22
<210> 8867
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8867
cugugugcaa cgcuuuuugg ga 22
<210> 8868
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8868
cuguucugcc ucccagauga au 22
<210> 8869
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8869
cuguugcacu gauguccgga ga 22
<210> 8870
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8870
cuguugugug uugaaagcca cu 22
<210> 8871
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8871
cuguuucucu uauccuucac ga 22
<210> 8872
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8872
cuguuuucug ucgugugugu ug 22
<210> 8873
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8873
cuuaaaaaau gaauuuggcc ag 22
<210> 8874
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8874
cuuaagccag gaaagggauu ca 22
<210> 8875
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8875
cuuaaggaag guacaaaccc ac 22
<210> 8876
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8876
cuuaauaaau auuaagggug ac 22
<210> 8877
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8877
cuuaauauuu auuaagugcc ug 22
<210> 8878
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8878
cuuacuaugu ugcccaggcu gg 22
<210> 8879
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8879
cuuauccuuc acgaggaaag ga 22
<210> 8880
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8880
cuucaaagcc gugaucguga au 22
<210> 8881
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8881
cuucacgagg aaaggaagaa ac 22
<210> 8882
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8882
cuucacgcgg gagucugacg ga 22
<210> 8883
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8883
cuucagguuc uuucugaaau cg 22
<210> 8884
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8884
cuuccacuuc uaugcaaaug cc 22
<210> 8885
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8885
cuuccauguu ugaggauugu gu 22
<210> 8886
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8886
cuuccauucc cguggucucc uu 22
<210> 8887
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8887
cuucccagag gcagagccug ag 22
<210> 8888
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8888
cuuccccaau cuugucguug au 22
<210> 8889
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8889
cuuccugaga ccucgccggc cu 22
<210> 8890
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8890
cuuccuggag agaaauggag gu 22
<210> 8891
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8891
cuuccuuaag ccaggaaagg ga 22
<210> 8892
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8892
cuuccuuucc ucgugaagga ua 22
<210> 8893
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8893
cuucggacag ugcccaugca au 22
<210> 8894
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8894
cuucuauaca gugguuuaaa aa 22
<210> 8895
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8895
cuucuaugca aaugccucca ag 22
<210> 8896
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8896
cuucuaugca agccuugcua ga 22
<210> 8897
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8897
cuucucuggg ccugacaucc cc 22
<210> 8898
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8898
cuucucuguc uuugaauaaa ac 22
<210> 8899
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8899
cuucugggag auggguguca cu 22
<210> 8900
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8900
cuugaguuca ggaguuggag ac 22
<210> 8901
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8901
cuugcacuuu cucaguucag ag 22
<210> 8902
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8902
cuugcauaga agagguaaac ac 22
<210> 8903
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8903
cuugcuagac agccagguua gc 22
<210> 8904
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8904
cuugcuucuc ugggccugac au 22
<210> 8905
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8905
cuuggaggca uuugcauaga ag 22
<210> 8906
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8906
cuuggccgug aggacacgug gc 22
<210> 8907
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8907
cuuggguugg gauuuugguu uc 22
<210> 8908
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8908
cuugucguug auggguaugu gu 22
<210> 8909
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8909
cuugugacau cuucacgcgg ga 22
<210> 8910
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8910
cuuguuuuau ucaaagacag ag 22
<210> 8911
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8911
cuuuaugucc gcccaccuag ug 22
<210> 8912
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8912
cuuucaacac acaacagcag au 22
<210> 8913
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8913
cuuucaucuu ccauguuuga gg 22
<210> 8914
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8914
cuuucccugg ccugggaucc ca 22
<210> 8915
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8915
cuuuccucgu gaaggauaag ag 22
<210> 8916
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8916
cuuuccuggc uuaaggaagg ua 22
<210> 8917
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8917
cuuucgaggu ggguuuguac cu 22
<210> 8918
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8918
cuuucucagu ucagaguugu ac 22
<210> 8919
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8919
cuuucugaaa ucgccguguu ac 22
<210> 8920
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8920
cuuucugguu ucggagcacg ua 22
<210> 8921
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8921
cuuugaaguc ccggucaacc ug 22
<210> 8922
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8922
cuuugaauaa aacaaggccg gc 22
<210> 8923
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8923
cuuugcccug ucacccccga au 22
<210> 8924
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8924
cuuugggagg cugagcugga uc 22
<210> 8925
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8925
cuuuggucuu cucugucuuu ga 22
<210> 8926
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8926
cuuuguacau aaagaagagg ca 22
<210> 8927
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8927
cuuuguugcu caggccuggu cu 22
<210> 8928
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8928
cuuuuuggga gaaugauguc cc 22
<210> 8929
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8929
cuuuuugguu uuuguagaga ug 22
<210> 8930
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8930
gaaacaggcc cggggggacc ag 22
<210> 8931
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8931
gaaaccaaaa ucccaaccca ag 22
<210> 8932
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8932
gaaaccagaa aggcuuauca cg 22
<210> 8933
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8933
gaaacucaaa acuuccugga ga 22
<210> 8934
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8934
gaaagaaccu gaagucccgu ca 22
<210> 8935
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8935
gaaagacacu ggguggguca ug 22
<210> 8936
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8936
gaaagcagug gcauaaucau ag 22
<210> 8937
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8937
gaaagccacu ugcuucucug gg 22
<210> 8938
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8938
gaaagcccgu gucaaugaau gc 22
<210> 8939
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8939
gaaaggaaga aaccaaaauc cc 22
<210> 8940
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8940
gaaaggcuua ucacgguucc cu 22
<210> 8941
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8941
gaaagggauu cauggcgucg ga 22
<210> 8942
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8942
gaaaggggag gggaugucag gc 22
<210> 8943
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8943
gaaagugcaa ggagaccacg gg 22
<210> 8944
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8944
gaaaucgccg uguuacuguu gc 22
<210> 8945
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8945
gaaaugaucu ggcugaaucc gu 22
<210> 8946
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8946
gaaaugccuc uucuuuaugu ac 22
<210> 8947
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8947
gaaauggagg ugucauccug gu 22
<210> 8948
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8948
gaacaaauac agcaaccagg gu 22
<210> 8949
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8949
gaacaggcuu cggacagugc cc 22
<210> 8950
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8950
gaacaucugc cuggaguccc gu 22
<210> 8951
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8951
gaacccuucc ugagaccucg cc 22
<210> 8952
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8952
gaaccgugau aagccuuucu gg 22
<210> 8953
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8953
gaaccugaag ucccgucaaa cg 22
<210> 8954
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8954
gaacucaagu gauccagcuc ag 22
<210> 8955
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8955
gaacugagaa agugcaagga ga 22
<210> 8956
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8956
gaacugccau ugucgucuuu au 22
<210> 8957
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8957
gaacuggacu gugugcaacg cu 22
<210> 8958
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8958
gaagaaacca aaaucccaac cc 22
<210> 8959
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8959
gaagaccaaa gcauugccug cc 22
<210> 8960
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8960
gaagacccua uuucagaaau ac 22
<210> 8961
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8961
gaagaggcau uucagaggca au 22
<210> 8962
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8962
gaagagguaa acacguugac uc 22
<210> 8963
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8963
gaagaugaaa ggggagggga ug 22
<210> 8964
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8964
gaagauguca caagggauug gc 22
<210> 8965
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8965
gaagcaagug gcuuucaaca ca 22
<210> 8966
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8966
gaagcacuag gugggcggac au 22
<210> 8967
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8967
gaagccacuc auacauacaa cg 22
<210> 8968
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8968
gaagccuguu cugccuccca ga 22
<210> 8969
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8969
gaaggauaag agaaacaggc cc 22
<210> 8970
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8970
gaaggguucu gggcagggac gg 22
<210> 8971
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8971
gaagguacaa acccaccucg aa 22
<210> 8972
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8972
gaagguuuuu guagccugaa ug 22
<210> 8973
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8973
gaagucccgg ucaaccugcc cc 22
<210> 8974
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8974
gaagucccgu caaacgaucc ag 22
<210> 8975
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8975
gaagugaaug gcuuggaggc au 22
<210> 8976
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8976
gaaguggaag cacuaggugg gc 22
<210> 8977
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8977
gaaguggcau cauuugguga au 22
<210> 8978
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8978
gaagugggua ggggucggga gg 22
<210> 8979
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8979
gaaguuuuga guuucucucc ac 22
<210> 8980
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8980
gaauaaaaca aggccggcga gg 22
<210> 8981
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8981
gaauagucac ugaacaaaua ca 22
<210> 8982
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8982
gaauaucgag aacugccauu gu 22
<210> 8983
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8983
gaaucaugac ccacccagug uc 22
<210> 8984
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8984
gaaucccuuu ccuggcuuaa gg 22
<210> 8985
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8985
gaauccgugg uggcaccgag ac 22
<210> 8986
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8986
gaaugaguuu ggucucggug cc 22
<210> 8987
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8987
gaaugauguc cccguuguau gu 22
<210> 8988
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8988
gaaugccggg gacagagagg gg 22
<210> 8989
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8989
gaauggaagu ggguaggggu cg 22
<210> 8990
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8990
gaauggcuug gaggcauuug ca 22
<210> 8991
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8991
gaauuuggcc agacacaggu gc 22
<210> 8992
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8992
gacaagauug gggaagugaa ug 22
<210> 8993
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8993
gacaauggca guucucgaua uu 22
<210> 8994
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8994
gacaauugcc aaucccuugu ga 22
<210> 8995
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8995
gacacaaucc ucaaacaugg aa 22
<210> 8996
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8996
gacacaggug ccucacgccu gu 22
<210> 8997
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8997
gacacagugu uuugucccug gg 22
<210> 8998
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8998
gacaccagcc uggugcccau cc 22
<210> 8999
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 8999
gacacccauc ucccagaagc ca 22
<210> 9000
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9000
gacacccggu uaccuuggcc gu 22
<210> 9001
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9001
gacaccucca uuucucucca gg 22
<210> 9002
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9002
gacacgggcu uucccuggcc ug 22
<210> 9003
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9003
gacacguggc cugcacccag gu 22
<210> 9004
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9004
gacacugggu gggucaugau uc 22
<210> 9005
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9005
gacagaaaac agugcaaaau aa 22
<210> 9006
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9006
gacagagaag accaaagcau ug 22
<210> 9007
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9007
gacagagagg ggcagguuga cc 22
<210> 9008
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9008
gacagauggu cagucuggag ga 22
<210> 9009
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9009
gacagccaca ccugggugca gg 22
<210> 9010
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9010
gacagccagg uuagccuuug cc 22
<210> 9011
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9011
gacagccuca aaugccugag cu 22
<210> 9012
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9012
gacagccucc gucagacucc cg 22
<210> 9013
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9013
gacagggcaa aggcuaaccu gg 22
<210> 9014
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9014
gacagugaca gccuccguca ga 22
<210> 9015
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9015
gacagugccc augcaauggc uu 22
<210> 9016
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9016
gacauaaaga cgacaauggc ag 22
<210> 9017
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9017
gacaucagug caacaguaac ac 22
<210> 9018
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9018
gacaucauuc ucccaaaaag cg 22
<210> 9019
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9019
gacauccccu ccccuuucau cu 22
<210> 9020
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9020
gacaucuuca cgcgggaguc ug 22
<210> 9021
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9021
gacauucagg cuacaaaaac cu 22
<210> 9022
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9022
gaccaaacuc auucaccaaa ug 22
<210> 9023
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9023
gaccaaagca uugccugcca ga 22
<210> 9024
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9024
gaccacggga auggaagugg gu 22
<210> 9025
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9025
gaccaggaug acaccuccau uu 22
<210> 9026
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9026
gaccaggccu gagcaacaaa gc 22
<210> 9027
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9027
gaccagugac ucaggcucug cc 22
<210> 9028
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9028
gacccaccca gugucuuucg ag 22
<210> 9029
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9029
gaccccaucu cuuaaaaaau ga 22
<210> 9030
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9030
gacccccugg cccugccuca uc 22
<210> 9031
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9031
gaccccuacc cacuuccauu cc 22
<210> 9032
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9032
gaccgggacu ucaaagccgu ga 22
<210> 9033
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9033
gaccucgccg gccuuguuuu au 22
<210> 9034
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9034
gacgacaaug gcaguucucg au 22
<210> 9035
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9035
gacgcauuua cgugcuccga aa 22
<210> 9036
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9036
gacgccauga aucccuuucc ug 22
<210> 9037
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9037
gacggaggcu gucacugucu cu 22
<210> 9038
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9038
gacgggacuc caggcagaug uu 22
<210> 9039
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9039
gacgggacuu cagguucuuu cu 22
<210> 9040
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9040
gacguggcgu gaacaucugc cu 22
<210> 9041
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9041
gacuauucuc ggggcccugu gu 22
<210> 9042
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9042
gacucaggcu cugccucugg ga 22
<210> 9043
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9043
gacuccaggc agauguucac gc 22
<210> 9044
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9044
gacucccgcg ugaagauguc ac 22
<210> 9045
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9045
gacuccugag uuuagggguu ug 22
<210> 9046
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9046
gacugugugc aacgcuuuuu gg 22
<210> 9047
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9047
gacuucaaag ccgugaucgu ga 22
<210> 9048
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9048
gacuucaggu ucuuucugaa au 22
<210> 9049
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9049
gagaaacagg cccgggggga cc 22
<210> 9050
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9050
gagaaacuca aaacuuccug ga 22
<210> 9051
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9051
gagaaagugc aaggagacca cg 22
<210> 9052
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9052
gagaaaugga ggugucaucc ug 22
<210> 9053
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9053
gagaacugcc auugucgucu uu 22
<210> 9054
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9054
gagaagacca aagcauugcc ug 22
<210> 9055
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9055
gagaagcaag uggcuuucaa ca 22
<210> 9056
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9056
gagaauaguc acugaacaaa ua 22
<210> 9057
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9057
gagaaugaug uccccguugu au 22
<210> 9058
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9058
gagacacccg guuaccuugg cc 22
<210> 9059
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9059
gagacagaug gucagucugg ag 22
<210> 9060
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9060
gagacaguga cagccuccgu ca 22
<210> 9061
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9061
gagaccaaac ucauucacca aa 22
<210> 9062
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9062
gagaccacgg gaauggaagu gg 22
<210> 9063
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9063
gagaccaggc cugagcaaca aa 22
<210> 9064
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9064
gagaccucgc cggccuuguu uu 22
<210> 9065
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9065
gagagaaacu caaaacuucc ug 22
<210> 9066
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9066
gagagaaaug gaggugucau cc 22
<210> 9067
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9067
gagagacagu gacagccucc gu 22
<210> 9068
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9068
gagaggggca gguugaccgg ga 22
<210> 9069
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9069
gagaucccau cucuacaaaa ac 22
<210> 9070
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9070
gagaugggau cucgcuuugu ug 22
<210> 9071
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9071
gagaugggug ucacuuuuua aa 22
<210> 9072
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9072
gagauuggug gaugaggcag gg 22
<210> 9073
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9073
gagcaacaaa gcgagauccc au 22
<210> 9074
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9074
gagcacguaa augcgucccu gu 22
<210> 9075
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9075
gagccacugc gcccggccuc ac 22
<210> 9076
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9076
gagccugagu cacuggucac cc 22
<210> 9077
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9077
gagcuaugau uaugccacug cu 22
<210> 9078
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9078
gagcucaggc auuugaggcu gu 22
<210> 9079
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9079
gagcuggauc acuugaguuc ag 22
<210> 9080
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9080
gaggaaagga agaaaccaaa au 22
<210> 9081
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9081
gaggacacgu ggccugcacc ca 22
<210> 9082
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9082
gaggaugacg uggcgugaac au 22
<210> 9083
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9083
gaggaugggc accaggcugg ug 22
<210> 9084
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9084
gaggaugguu ugagcucagg ca 22
<210> 9085
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9085
gaggauugug ucacggugga ga 22
<210> 9086
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9086
gaggcaauaa cccccuacac ag 22
<210> 9087
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9087
gaggcaccug ugucuggcca aa 22
<210> 9088
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9088
gaggcagaac aggcuucgga ca 22
<210> 9089
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9089
gaggcagagc cugagucacu gg 22
<210> 9090
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9090
gaggcagggc cagggggucc cg 22
<210> 9091
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9091
gaggcauuuc agaggcaaua ac 22
<210> 9092
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9092
gaggcauuug cauagaagug ga 22
<210> 9093
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9093
gaggccaugg gcugcugaug ca 22
<210> 9094
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9094
gaggcugagc uggaucacuu ga 22
<210> 9095
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9095
gaggcuguca cugucucucc gg 22
<210> 9096
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9096
gaggggaugu caggcccaga ga 22
<210> 9097
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9097
gaggggcagg uugaccggga cu 22
<210> 9098
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9098
gagguaaaca cguugacucc ug 22
<210> 9099
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9099
gaggucucag gaaggguucu gg 22
<210> 9100
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9100
gaggugggag gaugguuuga gc 22
<210> 9101
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9101
gagguggguu uguaccuucc uu 22
<210> 9102
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9102
gaggugucau ccuggucccc cc 22
<210> 9103
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9103
gagucaacgu guuuaccucu uc 22
<210> 9104
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9104
gagucacugg ucacccuuaa ua 22
<210> 9105
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9105
gagucccguc ccugcccaga ac 22
<210> 9106
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9106
gagucugacg gaggcuguca cu 22
<210> 9107
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9107
gaguggcuuc ugggagaugg gu 22
<210> 9108
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9108
gaguucagga guuggagacc ag 22
<210> 9109
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9109
gaguuggaga ccaggccuga gc 22
<210> 9110
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9110
gaguuguaca cuguguacau uu 22
<210> 9111
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9111
gaguuuaggg guuuggcuua ga 22
<210> 9112
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9112
gaguuucucu ccaccgugac ac 22
<210> 9113
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9113
gaguuugguc ucggugccac ca 22
<210> 9114
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9114
gauaagagaa acaggcccgg gg 22
<210> 9115
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9115
gauaagccuu ucugguuucg ga 22
<210> 9116
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9116
gauagugggg auuuuuuguu au 22
<210> 9117
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9117
gauauucacg aucacggcuu ug 22
<210> 9118
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9118
gaucacaggc acgugccacc gu 22
<210> 9119
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9119
gaucacagua agacauucag gc 22
<210> 9120
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9120
gaucacggcu uugaaguccc gg 22
<210> 9121
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9121
gaucauuucc gacgccauga au 22
<210> 9122
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9122
gauccagacu ggaggauuua uu 22
<210> 9123
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9123
gauccagcuc agccucccaa ag 22
<210> 9124
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9124
gaucccaggc cagggaaagc cc 22
<210> 9125
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9125
gaucccaucc caacacacac ga 22
<210> 9126
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9126
gaucccaucu cuacaaaaac ca 22
<210> 9127
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9127
gaucgugaau aucgagaacu gc 22
<210> 9128
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9128
gaucguuuga cgggacuuca gg 22
<210> 9129
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9129
gaucucgcuu uguugcucag gc 22
<210> 9130
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9130
gaucuggcug aauccguggu gg 22
<210> 9131
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9131
gaugaaaggg gaggggaugu ca 22
<210> 9132
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9132
gaugaagacc cuauuucaga aa 22
<210> 9133
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9133
gaugacaccu ccauuucucu cc 22
<210> 9134
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9134
gaugacgugg cgugaacauc ug 22
<210> 9135
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9135
gaugaggcag ggccaggggg uc 22
<210> 9136
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9136
gaugccacuu cccagaggca ga 22
<210> 9137
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9137
gauggcacca acgggacccc cu 22
<210> 9138
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9138
gaugggaucc caggccaggg aa 22
<210> 9139
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9139
gaugggaucu cgcuuuguug cu 22
<210> 9140
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9140
gauggguaug uguuuaaaac au 22
<210> 9141
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9141
gauggguguc acuuuuuaaa cc 22
<210> 9142
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9142
gauggucagu cuggaggaug ac 22
<210> 9143
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9143
gaugguuuga gcucaggcau uu 22
<210> 9144
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9144
gaugucacaa gggauuggca au 22
<210> 9145
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9145
gaugucaggc ccagagaagc aa 22
<210> 9146
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9146
gauguccccg uuguauguau ga 22
<210> 9147
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9147
gauguccgga gagacaguga ca 22
<210> 9148
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9148
gauguucacg ccacgucauc cu 22
<210> 9149
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9149
gauuacaggc gugaggcacc ug 22
<210> 9150
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9150
gauuaugcca cugcuuucca gc 22
<210> 9151
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9151
gauuauuugc acgaacugga cu 22
<210> 9152
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9152
gauucagcca gaucauuucc ga 22
<210> 9153
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9153
gauucauggc gucggaaaug au 22
<210> 9154
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9154
gauucggggg ugacagggca aa 22
<210> 9155
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9155
gauuggcaau uguccccagg ga 22
<210> 9156
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9156
gauuggggaa gugaauggcu ug 22
<210> 9157
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9157
gauuggugga ugaggcaggg cc 22
<210> 9158
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9158
gauuguguca cgguggagag aa 22
<210> 9159
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9159
gauuucagaa agaaccugaa gu 22
<210> 9160
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9160
gauuuugguu ucuuccuuuc cu 22
<210> 9161
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9161
gcaaacauaa caaaaaaucc cc 22
<210> 9162
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9162
gcaaacccug guugcuguau uu 22
<210> 9163
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9163
gcaaaggcua accuggcugu cu 22
<210> 9164
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9164
gcaaaugccu ccaagccauu ca 22
<210> 9165
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9165
gcaacagaug aagacccuau uu 22
<210> 9166
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9166
gcaacaguaa cacggcgauu uc 22
<210> 9167
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9167
gcaaccaggg uuugcaaaaa ua 22
<210> 9168
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9168
gcaacgcuuu uugggagaau ga 22
<210> 9169
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9169
gcaagccuug cuagacagcc ag 22
<210> 9170
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9170
gcaaggagac cacgggaaug ga 22
<210> 9171
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9171
gcaaggcuug cauagaagag gu 22
<210> 9172
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9172
gcaaguggcu uucaacacac aa 22
<210> 9173
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9173
gcaaugcuuu ggucuucucu gu 22
<210> 9174
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9174
gcaauggcuu ggguugggau uu 22
<210> 9175
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9175
gcaauugucc ccagggacaa aa 22
<210> 9176
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9176
gcacacaguc caguucgugc aa 22
<210> 9177
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9177
gcaccaacgg gacccccugg cc 22
<210> 9178
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9178
gcaccaggcu gguguccuga ca 22
<210> 9179
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9179
gcacccaggu guggcuguca gg 22
<210> 9180
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9180
gcaccgagac caaacucauu ca 22
<210> 9181
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9181
gcaccugugu cuggccaaau uc 22
<210> 9182
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9182
gcacgaacug gacugugugc aa 22
<210> 9183
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9183
gcacggugag gccgggcgca gu 22
<210> 9184
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9184
gcacguaaau gcgucccugu ac 22
<210> 9185
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9185
gcacgugcca ccguacccag cu 22
<210> 9186
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9186
gcacuaggug ggcggacaua aa 22
<210> 9187
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9187
gcacugaugu ccggagagac ag 22
<210> 9188
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9188
gcacuguccg aagccuguuc ug 22
<210> 9189
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9189
gcacuguuuu cugucgugug ug 22
<210> 9190
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9190
gcacuuaaua aauauuaagg gu 22
<210> 9191
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9191
gcacuuucuc aguucagagu ug 22
<210> 9192
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9192
gcacuuuggg aggcugagcu gg 22
<210> 9193
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9193
gcacuuugua uauugguuga aa 22
<210> 9194
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9194
gcagaacagg cuucggacag ug 22
<210> 9195
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9195
gcagagccug agucacuggu ca 22
<210> 9196
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9196
gcagauggca ccaacgggac cc 22
<210> 9197
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9197
gcagauguuc acgccacguc au 22
<210> 9198
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9198
gcagcccaug gccucuggcc ag 22
<210> 9199
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9199
gcaggcaaug cuuuggucuu cu 22
<210> 9200
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9200
gcaggccacg uguccucacg gc 22
<210> 9201
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9201
gcagggaacc gugauaagcc uu 22
<210> 9202
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9202
gcagggacgg gacuccaggc ag 22
<210> 9203
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9203
gcagggccag ggggucccgu ug 22
<210> 9204
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9204
gcagguugac cgggacuuca aa 22
<210> 9205
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9205
gcaguggcau aaucauagcu ca 22
<210> 9206
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9206
gcaguucucg auauucacga uc 22
<210> 9207
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9207
gcauaaucau agcucacgac ag 22
<210> 9208
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9208
gcauagaaga gguaaacacg uu 22
<210> 9209
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9209
gcauagaagu ggaagcacua gg 22
<210> 9210
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9210
gcaucagcag cccauggccu cu 22
<210> 9211
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9211
gcaucauuug gugaaugagu uu 22
<210> 9212
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9212
gcauggcgag gcugaggugg ga 22
<210> 9213
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9213
gcaugggcac uguccgaagc cu 22
<210> 9214
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9214
gcauggugca ucagcagccc au 22
<210> 9215
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9215
gcauguuuua aacacauacc ca 22
<210> 9216
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9216
gcauucauug acacgggcuu uc 22
<210> 9217
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9217
gcauugccug ccagagcuuu gu 22
<210> 9218
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9218
gcauuuacgu gcuccgaaac ca 22
<210> 9219
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9219
gcauuucaga ggcaauaacc cc 22
<210> 9220
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9220
gcauuugagg cugucgugag cu 22
<210> 9221
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9221
gcauuugcau agaaguggaa gc 22
<210> 9222
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9222
gccaaacccc uaaacucagg ag 22
<210> 9223
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9223
gccaaaugua cacaguguac aa 22
<210> 9224
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9224
gccaaauuca uuuuuuaaga ga 22
<210> 9225
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9225
gccaagguaa ccgggugucu ca 22
<210> 9226
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9226
gccaaucccu ugugacaucu uc 22
<210> 9227
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9227
gccacaccug ggugcaggcc ac 22
<210> 9228
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9228
gccaccacgg auucagccag au 22
<210> 9229
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9229
gccaccguac ccagcugauu uu 22
<210> 9230
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9230
gccacgucau ccuccagacu ga 22
<210> 9231
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9231
gccacguguc cucacggcca ag 22
<210> 9232
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9232
gccacucaua cauacaacgg gg 22
<210> 9233
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9233
gccacugcgc ccggccucac cg 22
<210> 9234
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9234
gccacuuccc agaggcagag cc 22
<210> 9235
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9235
gccacuugcu ucucugggcc ug 22
<210> 9236
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9236
gccagacaca ggugccucac gc 22
<210> 9237
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9237
gccagaggcc augggcugcu ga 22
<210> 9238
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9238
gccagaucau uuccgacgcc au 22
<210> 9239
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9239
gccaggaaag ggauucaugg cg 22
<210> 9240
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9240
gccaggcaug gcgaggcuga gg 22
<210> 9241
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9241
gccagggaaa gcccguguca au 22
<210> 9242
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9242
gccagggggu cccguuggug cc 22
<210> 9243
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9243
gccagguuag ccuuugcccu gu 22
<210> 9244
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9244
gccaucugcu guuguguguu ga 22
<210> 9245
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9245
gccaugaauc ccuuuccugg cu 22
<210> 9246
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9246
gccaugccug gccagaggcc au 22
<210> 9247
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9247
gccaugggcu gcugaugcac ca 22
<210> 9248
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9248
gccauucacu uccccaaucu ug 22
<210> 9249
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9249
gccauugcau gggcacuguc cg 22
<210> 9250
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9250
gccauugucg ucuuuauguc cg 22
<210> 9251
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9251
gcccaccuag ugcuuccacu uc 22
<210> 9252
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9252
gcccagaacc cuuccugaga cc 22
<210> 9253
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9253
gcccagagaa gcaaguggcu uu 22
<210> 9254
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9254
gcccaggcug gaaagcagug gc 22
<210> 9255
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9255
gcccauccuc ccgaccccua cc 22
<210> 9256
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9256
gcccaugcaa uggcuugggu ug 22
<210> 9257
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9257
gcccauggcc ucuggccagg ca 22
<210> 9258
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9258
gccccgagaa uagucacuga ac 22
<210> 9259
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9259
gccccucucu guccccggca uu 22
<210> 9260
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9260
gcccggccuc accgugcaug uu 22
<210> 9261
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9261
gcccgggggg accaggauga ca 22
<210> 9262
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9262
gcccguguca augaaugccg gg 22
<210> 9263
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9263
gcccugccuc auccaccaau cu 22
<210> 9264
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9264
gcccugucac ccccgaauca ug 22
<210> 9265
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9265
gcccugugua ggggguuauu gc 22
<210> 9266
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9266
gccggccuug uuuuauucaa ag 22
<210> 9267
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9267
gccggcgagg ucucaggaag gg 22
<210> 9268
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9268
gccggggaca gagaggggca gg 22
<210> 9269
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9269
gccgugagga cacguggccu gc 22
<210> 9270
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9270
gccgugaucg ugaauaucga ga 22
<210> 9271
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9271
gccguguuac uguugcacug au 22
<210> 9272
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9272
gccucaaaug ccugagcuca aa 22
<210> 9273
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9273
gccucaccgu gcauguuuua aa 22
<210> 9274
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9274
gccucaucca ccaaucucua ag 22
<210> 9275
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9275
gccuccaagc cauucacuuc cc 22
<210> 9276
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9276
gccucccaga ugaauaaaua ua 22
<210> 9277
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9277
gccuccguca gacucccgcg ug 22
<210> 9278
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9278
gccucgccau gccuggccag ag 22
<210> 9279
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9279
gccucugaaa ugccucuucu uu 22
<210> 9280
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9280
gccucuggcc aggcauggcg ag 22
<210> 9281
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9281
gccucuggga aguggcauca uu 22
<210> 9282
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9282
gccugaaugu cuuacuguga uc 22
<210> 9283
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9283
gccugacauc cccuccccuu uc 22
<210> 9284
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9284
gccugagaca cccgguuacc uu 22
<210> 9285
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9285
gccugagcaa caaagcgaga uc 22
<210> 9286
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9286
gccugagcuc aaaccauccu cc 22
<210> 9287
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9287
gccugaguca cuggucaccc uu 22
<210> 9288
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9288
gccugcaccc agguguggcu gu 22
<210> 9289
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9289
gccugccaga gcuuuguuuu au 22
<210> 9290
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9290
gccuggaguc ccgucccugc cc 22
<210> 9291
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9291
gccuggccag aggccauggg cu 22
<210> 9292
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9292
gccugggauc ccaucccaac ac 22
<210> 9293
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9293
gccuggugcc cauccucccg ac 22
<210> 9294
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9294
gccuguucug ccucccagau ga 22
<210> 9295
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9295
gccuguuucu cuuauccuuc ac 22
<210> 9296
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9296
gccuugcuag acagccaggu ua 22
<210> 9297
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9297
gccuuguuuu auucaaagac ag 22
<210> 9298
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9298
gccuuucugg uuucggagca cg 22
<210> 9299
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9299
gccuuugccc ugucaccccc ga 22
<210> 9300
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9300
gcgagauccc aucucuacaa aa 22
<210> 9301
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9301
gcgaggucuc aggaaggguu cu 22
<210> 9302
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9302
gcgauuucag aaagaaccug aa 22
<210> 9303
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9303
gcgcccggcc ucaccgugca ug 22
<210> 9304
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9304
gcggacauaa agacgacaau gg 22
<210> 9305
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9305
gcgggagucu gacggaggcu gu 22
<210> 9306
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9306
gcgucccugu acagauagug gg 22
<210> 9307
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9307
gcgucggaaa ugaucuggcu ga 22
<210> 9308
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9308
gcgugaacau cugccuggag uc 22
<210> 9309
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9309
gcgugaagau gucacaaggg au 22
<210> 9310
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9310
gcgugagcca cugcgcccgg cc 22
<210> 9311
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9311
gcgugaggca ccugugucug gc 22
<210> 9312
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9312
gcguugcaca caguccaguu cg 22
<210> 9313
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9313
gcuaaccugg cugucuagca ag 22
<210> 9314
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9314
gcuacaaaaa ccuucuauac ag 22
<210> 9315
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9315
gcuagacagc cagguuagcc uu 22
<210> 9316
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9316
gcuaugauua ugccacugcu uu 22
<210> 9317
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9317
gcucacgaca gccucaaaug cc 22
<210> 9318
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9318
gcucaggcau uugaggcugu cg 22
<210> 9319
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9319
gcucaggccu ggucuccaac uc 22
<210> 9320
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9320
gcuccgaaac cagaaaggcu ua 22
<210> 9321
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9321
gcucgaucau ggcucacugc aa 22
<210> 9322
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9322
gcucugccuc ugggaagugg ca 22
<210> 9323
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9323
gcucuggcag gcaaugcuuu gg 22
<210> 9324
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9324
gcugaauccg ugguggcacc ga 22
<210> 9325
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9325
gcugagcugg aucacuugag uu 22
<210> 9326
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9326
gcugcugaug caccaugcau gg 22
<210> 9327
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9327
gcuggaaagc aguggcauaa uc 22
<210> 9328
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9328
gcuggaucac uugaguucag ga 22
<210> 9329
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9329
gcugggauua caggcgugag gc 22
<210> 9330
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9330
gcuggguacg guggcacgug cc 22
<210> 9331
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9331
gcuggugucc ugacagccac ac 22
<210> 9332
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9332
gcuguauuug uucagugacu au 22
<210> 9333
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9333
gcugucacug ucucuccgga ca 22
<210> 9334
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9334
gcugucagga caccagccug gu 22
<210> 9335
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9335
gcugucuagc aaggcuugca ua 22
<210> 9336
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9336
gcuguugugu guugaaagcc ac 22
<210> 9337
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9337
gcuuaaggaa gguacaaacc ca 22
<210> 9338
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9338
gcuuagagau ugguggauga gg 22
<210> 9339
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9339
gcuuaucacg guucccugca cu 22
<210> 9340
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9340
gcuuccacuu cuaugcaaau gc 22
<210> 9341
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9341
gcuucggaca gugcccaugc aa 22
<210> 9342
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9342
gcuucucugg gccugacauc cc 22
<210> 9343
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9343
gcuucuggga gauggguguc ac 22
<210> 9344
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9344
gcuugcauag aagagguaaa ca 22
<210> 9345
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9345
gcuuggaggc auuugcauag aa 22
<210> 9346
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9346
gcuuggguug ggauuuuggu uu 22
<210> 9347
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9347
gcuuucaaca cacaacagca ga 22
<210> 9348
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9348
gcuuuccagc cugggcaaca ua 22
<210> 9349
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9349
gcuuucccug gccugggauc cc 22
<210> 9350
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9350
gcuuugaagu cccggucaac cu 22
<210> 9351
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9351
gcuuuggucu ucucugucuu ug 22
<210> 9352
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9352
gcuuuguugc ucaggccugg uc 22
<210> 9353
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9353
gcuuuuuggg agaaugaugu cc 22
<210> 9354
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9354
ggaaagcagu ggcauaauca ua 22
<210> 9355
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9355
ggaaagcccg ugucaaugaa ug 22
<210> 9356
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9356
ggaaaggaag aaaccaaaau cc 22
<210> 9357
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9357
ggaaagggau ucauggcguc gg 22
<210> 9358
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9358
ggaaaugauc uggcugaauc cg 22
<210> 9359
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9359
ggaaccguga uaagccuuuc ug 22
<210> 9360
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9360
ggaagaaacc aaaaucccaa cc 22
<210> 9361
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9361
ggaagaugaa aggggagggg au 22
<210> 9362
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9362
ggaagcacua ggugggcgga ca 22
<210> 9363
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9363
ggaaggguuc ugggcaggga cg 22
<210> 9364
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9364
ggaagguaca aacccaccuc ga 22
<210> 9365
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9365
ggaagugaau ggcuuggagg ca 22
<210> 9366
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9366
ggaaguggca ucauuuggug aa 22
<210> 9367
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9367
ggaagugggu aggggucggg ag 22
<210> 9368
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9368
ggaaguuuug aguuucucuc ca 22
<210> 9369
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9369
ggaauggaag uggguagggg uc 22
<210> 9370
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9370
ggacaauugc caaucccuug ug 22
<210> 9371
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9371
ggacacagug uuuugucccu gg 22
<210> 9372
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9372
ggacaccagc cuggugccca uc 22
<210> 9373
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9373
ggacacgugg ccugcaccca gg 22
<210> 9374
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9374
ggacagagag gggcagguug ac 22
<210> 9375
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9375
ggacagugcc caugcaaugg cu 22
<210> 9376
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9376
ggacauaaag acgacaaugg ca 22
<210> 9377
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9377
ggacaucagu gcaacaguaa ca 22
<210> 9378
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9378
ggacaucauu cucccaaaaa gc 22
<210> 9379
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9379
ggaccaggau gacaccucca uu 22
<210> 9380
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9380
ggacccccug gcccugccuc au 22
<210> 9381
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9381
ggacgcauuu acgugcuccg aa 22
<210> 9382
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9382
ggacgggacu ccaggcagau gu 22
<210> 9383
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9383
ggacuccagg cagauguuca cg 22
<210> 9384
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9384
ggacugugug caacgcuuuu ug 22
<210> 9385
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9385
ggacuucaaa gccgugaucg ug 22
<210> 9386
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9386
ggacuucagg uucuuucuga aa 22
<210> 9387
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9387
ggagaaugau guccccguug ua 22
<210> 9388
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9388
ggagaccacg ggaauggaag ug 22
<210> 9389
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9389
ggagaccagg ccugagcaac aa 22
<210> 9390
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9390
ggagagaaac ucaaaacuuc cu 22
<210> 9391
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9391
ggagagaaau ggagguguca uc 22
<210> 9392
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9392
ggagagacag ugacagccuc cg 22
<210> 9393
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9393
ggagaugggu gucacuuuuu aa 22
<210> 9394
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9394
ggagcacgua aaugcguccc ug 22
<210> 9395
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9395
ggaggaugac guggcgugaa ca 22
<210> 9396
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9396
ggaggauggg caccaggcug gu 22
<210> 9397
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9397
ggaggauggu uugagcucag gc 22
<210> 9398
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9398
ggaggcagaa caggcuucgg ac 22
<210> 9399
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9399
ggaggcauuu gcauagaagu gg 22
<210> 9400
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9400
ggaggcugag cuggaucacu ug 22
<210> 9401
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9401
ggaggcuguc acugucucuc cg 22
<210> 9402
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9402
ggaggggaug ucaggcccag ag 22
<210> 9403
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9403
ggagguguca uccugguccc cc 22
<210> 9404
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9404
ggagguugca gugagccaug au 22
<210> 9405
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9405
ggagucaacg uguuuaccuc uu 22
<210> 9406
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9406
ggagucccgu cccugcccag aa 22
<210> 9407
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9407
ggagucugac ggaggcuguc ac 22
<210> 9408
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9408
ggaguuggag accaggccug ag 22
<210> 9409
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9409
ggauaagaga aacaggcccg gg 22
<210> 9410
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9410
ggaucacagg cacgugccac cg 22
<210> 9411
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9411
ggaucccagg ccagggaaag cc 22
<210> 9412
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9412
ggaucccauc ccaacacaca cg 22
<210> 9413
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9413
ggaucguuug acgggacuuc ag 22
<210> 9414
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9414
ggaugacacc uccauuucuc uc 22
<210> 9415
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9415
ggaugacgug gcgugaacau cu 22
<210> 9416
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9416
ggaugaggca gggccagggg gu 22
<210> 9417
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9417
ggaugggauc ccaggccagg ga 22
<210> 9418
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9418
ggaugggcac caggcuggug uc 22
<210> 9419
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9419
ggaugguuug agcucaggca uu 22
<210> 9420
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9420
ggaugucagg cccagagaag ca 22
<210> 9421
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9421
ggauuacagg cgugaggcac cu 22
<210> 9422
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9422
ggauucagcc agaucauuuc cg 22
<210> 9423
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9423
ggauucaugg cgucggaaau ga 22
<210> 9424
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9424
ggauuggcaa uuguccccag gg 22
<210> 9425
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9425
ggauuguguc acgguggaga ga 22
<210> 9426
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9426
ggauuuuggu uucuuccuuu cc 22
<210> 9427
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9427
ggcaaaggcu aaccuggcug uc 22
<210> 9428
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9428
ggcaacagau gaagacccua uu 22
<210> 9429
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9429
ggcaauaacc cccuacacag gg 22
<210> 9430
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9430
ggcaaugcuu uggucuucuc ug 22
<210> 9431
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9431
ggcaauuguc cccagggaca aa 22
<210> 9432
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9432
ggcaccaacg ggacccccug gc 22
<210> 9433
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9433
ggcaccaggc ugguguccug ac 22
<210> 9434
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9434
ggcaccgaga ccaaacucau uc 22
<210> 9435
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9435
ggcaccugug ucuggccaaa uu 22
<210> 9436
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9436
ggcacgugcc accguaccca gc 22
<210> 9437
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9437
ggcacugucc gaagccuguu cu 22
<210> 9438
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9438
ggcacuuaau aaauauuaag gg 22
<210> 9439
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9439
ggcagaacag gcuucggaca gu 22
<210> 9440
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9440
ggcagagccu gagucacugg uc 22
<210> 9441
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9441
ggcagauguu cacgccacgu ca 22
<210> 9442
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9442
ggcaggcaau gcuuuggucu uc 22
<210> 9443
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9443
ggcagggacg ggacuccagg ca 22
<210> 9444
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9444
ggcagggcca gggggucccg uu 22
<210> 9445
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9445
ggcagguuga ccgggacuuc aa 22
<210> 9446
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9446
ggcaguucuc gauauucacg au 22
<210> 9447
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9447
ggcauaauca uagcucacga ca 22
<210> 9448
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9448
ggcaucauuu ggugaaugag uu 22
<210> 9449
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9449
ggcauggcga ggcugaggug gg 22
<210> 9450
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9450
ggcauucauu gacacgggcu uu 22
<210> 9451
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9451
ggcauuucag aggcaauaac cc 22
<210> 9452
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9452
ggcauuugag gcugucguga gc 22
<210> 9453
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9453
ggcauuugca uagaagugga ag 22
<210> 9454
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9454
ggcauuugug uuauuauuuu gc 22
<210> 9455
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9455
ggccaaauuc auuuuuuaag ag 22
<210> 9456
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9456
ggccaaggua accggguguc uc 22
<210> 9457
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9457
ggccacgugu ccucacggcc aa 22
<210> 9458
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9458
ggccagacac aggugccuca cg 22
<210> 9459
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9459
ggccagaggc caugggcugc ug 22
<210> 9460
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9460
ggccaggcau ggcgaggcug ag 22
<210> 9461
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9461
ggccagggaa agcccguguc aa 22
<210> 9462
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9462
ggccaggggg ucccguuggu gc 22
<210> 9463
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9463
ggccaugggc ugcugaugca cc 22
<210> 9464
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9464
ggcccagaga agcaaguggc uu 22
<210> 9465
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9465
ggccccgaga auagucacug aa 22
<210> 9466
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9466
ggcccggggg gaccaggaug ac 22
<210> 9467
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9467
ggcccugccu cauccaccaa uc 22
<210> 9468
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9468
ggcccugugu aggggguuau ug 22
<210> 9469
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9469
ggccggcgag gucucaggaa gg 22
<210> 9470
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9470
ggccgugagg acacguggcc ug 22
<210> 9471
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9471
ggccucaccg ugcauguuuu aa 22
<210> 9472
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9472
ggccucuggc caggcauggc ga 22
<210> 9473
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9473
ggccugacau ccccuccccu uu 22
<210> 9474
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9474
ggccugagca acaaagcgag au 22
<210> 9475
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9475
ggccugcacc cagguguggc ug 22
<210> 9476
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9476
ggccugggau cccaucccaa ca 22
<210> 9477
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9477
ggccuggucu ccaacuccug aa 22
<210> 9478
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9478
ggccuguuuc ucuuauccuu ca 22
<210> 9479
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9479
ggccuuguuu uauucaaaga ca 22
<210> 9480
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9480
ggcgaggcug aggugggagg au 22
<210> 9481
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9481
ggcgaggucu caggaagggu uc 22
<210> 9482
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9482
ggcgauuuca gaaagaaccu ga 22
<210> 9483
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9483
ggcggacaua aagacgacaa ug 22
<210> 9484
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9484
ggcgucggaa augaucuggc ug 22
<210> 9485
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9485
ggcgugaaca ucugccugga gu 22
<210> 9486
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9486
ggcgugaggc accugugucu gg 22
<210> 9487
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9487
ggcuaaccug gcugucuagc aa 22
<210> 9488
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9488
ggcuacaaaa accuucuaua ca 22
<210> 9489
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9489
ggcucgauca uggcucacug ca 22
<210> 9490
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9490
ggcucugccu cugggaagug gc 22
<210> 9491
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9491
ggcugaaucc gugguggcac cg 22
<210> 9492
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9492
ggcugagcug gaucacuuga gu 22
<210> 9493
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9493
ggcugcugau gcaccaugca ug 22
<210> 9494
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9494
ggcuggaaag caguggcaua au 22
<210> 9495
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9495
ggcugguguc cugacagcca ca 22
<210> 9496
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9496
ggcugucacu gucucuccgg ac 22
<210> 9497
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9497
ggcugucagg acaccagccu gg 22
<210> 9498
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9498
ggcugucuag caaggcuugc au 22
<210> 9499
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9499
ggcuuaagga agguacaaac cc 22
<210> 9500
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9500
ggcuuagaga uugguggaug ag 22
<210> 9501
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9501
ggcuuaucac gguucccugc ac 22
<210> 9502
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9502
ggcuucggac agugcccaug ca 22
<210> 9503
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9503
ggcuucuggg agaugggugu ca 22
<210> 9504
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9504
ggcuugcaua gaagagguaa ac 22
<210> 9505
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9505
ggcuuggagg cauuugcaua ga 22
<210> 9506
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9506
ggcuuggguu gggauuuugg uu 22
<210> 9507
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9507
ggcuuucaac acacaacagc ag 22
<210> 9508
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9508
ggcuuucccu ggccugggau cc 22
<210> 9509
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9509
ggcuuugaag ucccggucaa cc 22
<210> 9510
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9510
gggaaagccc gugucaauga au 22
<210> 9511
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9511
gggaaccgug auaagccuuu cu 22
<210> 9512
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9512
gggaagugaa uggcuuggag gc 22
<210> 9513
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9513
gggaaguggc aucauuuggu ga 22
<210> 9514
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9514
gggaauggaa guggguaggg gu 22
<210> 9515
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9515
gggacaauug ccaaucccuu gu 22
<210> 9516
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9516
gggacacagu guuuuguccc ug 22
<210> 9517
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9517
gggacagaga ggggcagguu ga 22
<210> 9518
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9518
gggacaucau ucucccaaaa ag 22
<210> 9519
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9519
gggaccagga ugacaccucc au 22
<210> 9520
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9520
gggacccccu ggcccugccu ca 22
<210> 9521
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9521
gggacgcauu uacgugcucc ga 22
<210> 9522
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9522
gggacgggac uccaggcaga ug 22
<210> 9523
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9523
gggacuccag gcagauguuc ac 22
<210> 9524
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9524
gggacuucaa agccgugauc gu 22
<210> 9525
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9525
gggacuucag guucuuucug aa 22
<210> 9526
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9526
gggagaauga uguccccguu gu 22
<210> 9527
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9527
gggagauggg ugucacuuuu ua 22
<210> 9528
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9528
gggaggaugg gcaccaggcu gg 22
<210> 9529
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9529
gggaggaugg uuugagcuca gg 22
<210> 9530
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9530
gggaggcaga acaggcuucg ga 22
<210> 9531
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9531
gggaggcuga gcuggaucac uu 22
<210> 9532
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9532
gggaggggau gucaggccca ga 22
<210> 9533
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9533
gggagucuga cggaggcugu ca 22
<210> 9534
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9534
gggaucacag gcacgugcca cc 22
<210> 9535
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9535
gggaucccag gccagggaaa gc 22
<210> 9536
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9536
gggaucccau cccaacacac ac 22
<210> 9537
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9537
gggaucucgc uuuguugcuc ag 22
<210> 9538
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9538
gggaugggau cccaggccag gg 22
<210> 9539
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9539
gggaugucag gcccagagaa gc 22
<210> 9540
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9540
gggauuacag gcgugaggca cc 22
<210> 9541
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9541
gggauucaug gcgucggaaa ug 22
<210> 9542
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9542
gggauuggca auugucccca gg 22
<210> 9543
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9543
gggauuuugg uuucuuccuu uc 22
<210> 9544
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9544
gggauuuuuu guuauguuug ca 22
<210> 9545
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9545
gggcaaaggc uaaccuggcu gu 22
<210> 9546
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9546
gggcaacaga ugaagacccu au 22
<210> 9547
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9547
gggcaccagg cugguguccu ga 22
<210> 9548
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9548
gggcacuguc cgaagccugu uc 22
<210> 9549
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9549
gggcagggac gggacuccag gc 22
<210> 9550
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9550
gggcagguug accgggacuu ca 22
<210> 9551
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9551
gggccagggg gucccguugg ug 22
<210> 9552
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9552
gggccccgag aauagucacu ga 22
<210> 9553
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9553
gggcccugug uaggggguua uu 22
<210> 9554
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9554
gggccugaca uccccucccc uu 22
<210> 9555
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9555
gggccuguuu cucuuauccu uc 22
<210> 9556
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9556
gggcggacau aaagacgaca au 22
<210> 9557
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9557
gggcugcuga ugcaccaugc au 22
<210> 9558
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9558
gggcuuuccc uggccuggga uc 22
<210> 9559
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9559
ggggaaguga auggcuugga gg 22
<210> 9560
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9560
ggggacaauu gccaaucccu ug 22
<210> 9561
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9561
ggggacacag uguuuugucc cu 22
<210> 9562
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9562
ggggacagag aggggcaggu ug 22
<210> 9563
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9563
ggggacauca uucucccaaa aa 22
<210> 9564
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9564
ggggaccagg augacaccuc ca 22
<210> 9565
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9565
ggggagggga ugucaggccc ag 22
<210> 9566
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9566
ggggauguca ggcccagaga ag 22
<210> 9567
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9567
ggggauuuuu uguuauguuu gc 22
<210> 9568
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9568
ggggcagguu gaccgggacu uc 22
<210> 9569
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9569
ggggcccugu guaggggguu au 22
<210> 9570
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9570
gggggacaca guguuuuguc cc 22
<210> 9571
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9571
gggggaccag gaugacaccu cc 22
<210> 9572
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9572
ggggggacac aguguuuugu cc 22
<210> 9573
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9573
ggggggacca ggaugacacc uc 22
<210> 9574
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9574
gggggucccg uuggugccau cu 22
<210> 9575
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9575
gggggugaca gggcaaaggc ua 22
<210> 9576
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9576
ggggguuauu gccucugaaa ug 22
<210> 9577
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9577
ggggucccgu uggugccauc ug 22
<210> 9578
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9578
ggggucggga ggaugggcac ca 22
<210> 9579
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9579
ggggugacag ggcaaaggcu aa 22
<210> 9580
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9580
gggguuauug ccucugaaau gc 22
<210> 9581
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9581
gggguuuggc uuagagauug gu 22
<210> 9582
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9582
ggguacggug gcacgugccu gu 22
<210> 9583
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9583
ggguaggggu cgggaggaug gg 22
<210> 9584
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9584
ggguaugugu uuaaaacaug ca 22
<210> 9585
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9585
gggucaugau ucggggguga ca 22
<210> 9586
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9586
gggucccguu ggugccaucu gc 22
<210> 9587
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9587
gggucgggag gaugggcacc ag 22
<210> 9588
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9588
gggugacagg gcaaaggcua ac 22
<210> 9589
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9589
gggugaccag ugacucaggc uc 22
<210> 9590
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9590
gggugcaggc cacguguccu ca 22
<210> 9591
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9591
ggguggguca ugauucgggg gu 22
<210> 9592
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9592
gggugucacu uuuuaaacca cu 22
<210> 9593
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9593
gggugucuca ggcacuuaau aa 22
<210> 9594
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9594
ggguuauugc cucugaaaug cc 22
<210> 9595
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9595
ggguucuggg cagggacggg ac 22
<210> 9596
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9596
ggguugggau uuugguuucu uc 22
<210> 9597
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9597
ggguuuggcu uagagauugg ug 22
<210> 9598
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9598
ggguuuguac cuuccuuaag cc 22
<210> 9599
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9599
gguaaacacg uugacuccug ag 22
<210> 9600
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9600
gguaaccggg ugucucaggc ac 22
<210> 9601
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9601
gguacaaacc caccucgaaa ga 22
<210> 9602
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9602
gguagggguc gggaggaugg gc 22
<210> 9603
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9603
gguauguguu uaaaacaugc ac 22
<210> 9604
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9604
ggucaaccug ccccucucug uc 22
<210> 9605
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9605
ggucacccuu aauauuuauu aa 22
<210> 9606
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9606
ggucagucug gaggaugacg ug 22
<210> 9607
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9607
ggucaugauu cgggggugac ag 22
<210> 9608
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9608
gguccccccg ggccuguuuc uc 22
<210> 9609
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9609
ggucccguug gugccaucug cu 22
<210> 9610
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9610
ggucgggagg augggcacca gg 22
<210> 9611
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9611
ggucucagga aggguucugg gc 22
<210> 9612
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9612
ggucuccuug cacuuucuca gu 22
<210> 9613
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9613
ggucucggug ccaccacgga uu 22
<210> 9614
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9614
ggucuucucu gucuuugaau aa 22
<210> 9615
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9615
ggugaaugag uuuggucucg gu 22
<210> 9616
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9616
ggugacaggg caaaggcuaa cc 22
<210> 9617
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9617
ggugaccagu gacucaggcu cu 22
<210> 9618
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9618
ggugcaggcc acguguccuc ac 22
<210> 9619
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9619
ggugcaucag cagcccaugg cc 22
<210> 9620
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9620
ggugccacca cggauucagc ca 22
<210> 9621
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9621
ggugccaucu gcuguugugu gu 22
<210> 9622
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9622
ggugcccauc cucccgaccc cu 22
<210> 9623
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9623
gguggagaga aacucaaaac uu 22
<210> 9624
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9624
gguggagguu gcagugagcc au 22
<210> 9625
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9625
gguggaugag gcagggccag gg 22
<210> 9626
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9626
gguggcaccg agaccaaacu ca 22
<210> 9627
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9627
ggugggagga ugguuugagc uc 22
<210> 9628
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9628
ggugggcgga cauaaagacg ac 22
<210> 9629
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9629
ggugggucau gauucggggg ug 22
<210> 9630
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9630
gguggguuug uaccuuccuu aa 22
<210> 9631
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9631
ggugucacuu uuuaaaccac ug 22
<210> 9632
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9632
ggugucaucc uggucccccc gg 22
<210> 9633
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9633
gguguccuga cagccacacc ug 22
<210> 9634
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9634
ggugucucag gcacuuaaua aa 22
<210> 9635
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9635
gguguggcug ucaggacacc ag 22
<210> 9636
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9636
gguuaccuug gccgugagga ca 22
<210> 9637
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9637
gguuagccuu ugcccuguca cc 22
<210> 9638
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9638
gguuauugcc ucugaaaugc cu 22
<210> 9639
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9639
gguucugggc agggacggga cu 22
<210> 9640
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9640
gguucuuucu gaaaucgccg ug 22
<210> 9641
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9641
gguugaccgg gacuucaaag cc 22
<210> 9642
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9642
gguugcugua uuuguucagu ga 22
<210> 9643
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9643
gguugggauu uugguuucuu cc 22
<210> 9644
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9644
gguuuaaaaa gugacaccca uc 22
<210> 9645
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9645
gguuucggag cacguaaaug cg 22
<210> 9646
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9646
gguuucuucc uuuccucgug aa 22
<210> 9647
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9647
gguuugagcu caggcauuug ag 22
<210> 9648
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9648
gguuuggcuu agagauuggu gg 22
<210> 9649
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9649
gguuuguacc uuccuuaagc ca 22
<210> 9650
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9650
gguuuuugua gagaugggau cu 22
<210> 9651
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9651
gguuuuugua gccugaaugu cu 22
<210> 9652
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9652
guaaacacgu ugacuccuga gu 22
<210> 9653
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9653
guaaaugcgu cccuguacag au 22
<210> 9654
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9654
guaacacggc gauuucagaa ag 22
<210> 9655
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9655
guaaccgggu gucucaggca cu 22
<210> 9656
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9656
guaagacauu caggcuacaa aa 22
<210> 9657
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9657
guaagacccc aucucuuaaa aa 22
<210> 9658
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9658
guacaaaccc accucgaaag ac 22
<210> 9659
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9659
guacaaagau uauuugcacg aa 22
<210> 9660
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9660
guacaacucu gaacugagaa ag 22
<210> 9661
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9661
guacacagug uacaacucug aa 22
<210> 9662
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9662
guacacugug uacauuuggc au 22
<210> 9663
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9663
guacagauag uggggauuuu uu 22
<210> 9664
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9664
guacagggac gcauuuacgu gc 22
<210> 9665
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9665
guacauaaag aagaggcauu uc 22
<210> 9666
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9666
guacccagcu gauuuuuaac uu 22
<210> 9667
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9667
guaccuuccu uaagccagga aa 22
<210> 9668
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9668
guagagaugg gaucucgcuu ug 22
<210> 9669
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9669
guagccugaa ugucuuacug ug 22
<210> 9670
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9670
guaggggguu auugccucug aa 22
<210> 9671
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9671
guaggggucg ggaggauggg ca 22
<210> 9672
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9672
guauagaagg uuuuuguagc cu 22
<210> 9673
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9673
guaugagugg cuucugggag au 22
<210> 9674
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9674
guauguauga guggcuucug gg 22
<210> 9675
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9675
guauguguuu aaaacaugca cg 22
<210> 9676
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9676
guauuucuga aauagggucu uc 22
<210> 9677
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9677
guauuuguuc agugacuauu cu 22
<210> 9678
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9678
gucaaacgau ccagacugga gg 22
<210> 9679
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9679
gucaaccugc cccucucugu cc 22
<210> 9680
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9680
gucaacgugu uuaccucuuc ua 22
<210> 9681
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9681
gucaaugaau gccggggaca ga 22
<210> 9682
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9682
gucacaaggg auuggcaauu gu 22
<210> 9683
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9683
gucacccccg aaucaugacc ca 22
<210> 9684
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9684
gucacccuua auauuuauua ag 22
<210> 9685
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9685
gucacggugg agagaaacuc aa 22
<210> 9686
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9686
gucacugaac aaauacagca ac 22
<210> 9687
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9687
gucacugguc acccuuaaua uu 22
<210> 9688
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9688
gucacugucu cuccggacau ca 22
<210> 9689
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9689
gucacuuuuu aaaccacugu au 22
<210> 9690
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9690
gucagacucc cgcgugaaga ug 22
<210> 9691
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9691
gucaggacac cagccuggug cc 22
<210> 9692
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9692
gucaggccca gagaagcaag ug 22
<210> 9693
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9693
gucagucugg aggaugacgu gg 22
<210> 9694
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9694
gucauccucc agacugacca uc 22
<210> 9695
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9695
gucauccugg uccccccggg cc 22
<210> 9696
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9696
gucaugauuc gggggugaca gg 22
<210> 9697
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9697
guccaguucg ugcaaauaau cu 22
<210> 9698
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9698
guccccaggg acaaaacacu gu 22
<210> 9699
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9699
guccccccgg gccuguuucu cu 22
<210> 9700
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9700
guccccggca uucauugaca cg 22
<210> 9701
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9701
guccccguug uauguaugag ug 22
<210> 9702
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9702
gucccgguca accugccccu cu 22
<210> 9703
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9703
gucccgucaa acgauccaga cu 22
<210> 9704
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9704
gucccguccc ugcccagaac cc 22
<210> 9705
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9705
gucccguugg ugccaucugc ug 22
<210> 9706
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9706
gucccugccc agaacccuuc cu 22
<210> 9707
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9707
gucccugggg acaauugcca au 22
<210> 9708
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9708
gucccuguac agauaguggg ga 22
<210> 9709
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9709
guccgaagcc uguucugccu cc 22
<210> 9710
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9710
guccgcccac cuagugcuuc ca 22
<210> 9711
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9711
guccggagag acagugacag cc 22
<210> 9712
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9712
guccucacgg ccaagguaac cg 22
<210> 9713
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9713
guccugacag ccacaccugg gu 22
<210> 9714
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9714
gucggaaaug aucuggcuga au 22
<210> 9715
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9715
gucgggagga ugggcaccag gc 22
<210> 9716
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9716
gucgucuuua uguccgccca cc 22
<210> 9717
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9717
gucgugagcu augauuaugc ca 22
<210> 9718
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9718
gucgugugug uugggauggg au 22
<210> 9719
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9719
gucguugaug gguauguguu ua 22
<210> 9720
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9720
gucuagcaag gcuugcauag aa 22
<210> 9721
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9721
gucucaggaa ggguucuggg ca 22
<210> 9722
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9722
gucucaggca cuuaauaaau au 22
<210> 9723
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9723
gucuccuugc acuuucucag uu 22
<210> 9724
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9724
gucucggugc caccacggau uc 22
<210> 9725
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9725
gucucuccgg acaucagugc aa 22
<210> 9726
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9726
gucugacgga ggcugucacu gu 22
<210> 9727
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9727
gucuggagga ugacguggcg ug 22
<210> 9728
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9728
gucuggaucg uuugacggga cu 22
<210> 9729
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9729
gucuggccaa auucauuuuu ua 22
<210> 9730
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9730
gucuucucug ucuuugaaua aa 22
<210> 9731
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9731
gucuuuaugu ccgcccaccu ag 22
<210> 9732
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9732
gucuuucgag guggguuugu ac 22
<210> 9733
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9733
gucuuugaau aaaacaaggc cg 22
<210> 9734
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9734
gugaacaucu gccuggaguc cc 22
<210> 9735
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9735
gugaagaugu cacaagggau ug 22
<210> 9736
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9736
gugaaggaua agagaaacag gc 22
<210> 9737
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9737
gugaauaucg agaacugcca uu 22
<210> 9738
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9738
gugaaugagu uuggucucgg ug 22
<210> 9739
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9739
gugaauggcu uggaggcauu ug 22
<210> 9740
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9740
gugacacaau ccucaaacau gg 22
<210> 9741
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9741
gugacaccca ucucccagaa gc 22
<210> 9742
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9742
gugacagccu ccgucagacu cc 22
<210> 9743
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9743
gugacagggc aaaggcuaac cu 22
<210> 9744
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9744
gugacaucuu cacgcgggag uc 22
<210> 9745
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9745
gugaccagug acucaggcuc ug 22
<210> 9746
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9746
gugacuauuc ucggggcccu gu 22
<210> 9747
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9747
gugacucagg cucugccucu gg 22
<210> 9748
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9748
gugagccacu gcgcccggcc uc 22
<210> 9749
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9749
gugagcuaug auuaugccac ug 22
<210> 9750
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9750
gugaggacac guggccugca cc 22
<210> 9751
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9751
gugaggcacc ugugucuggc ca 22
<210> 9752
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9752
gugauaagcc uuucugguuu cg 22
<210> 9753
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9753
gugauccagc ucagccuccc aa 22
<210> 9754
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9754
gugaucguga auaucgagaa cu 22
<210> 9755
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9755
gugcaaacau aacaaaaaau cc 22
<210> 9756
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9756
gugcaacagu aacacggcga uu 22
<210> 9757
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9757
gugcaacgcu uuuugggaga au 22
<210> 9758
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9758
gugcaaggag accacgggaa ug 22
<210> 9759
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9759
gugcaggcca cguguccuca cg 22
<210> 9760
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9760
gugcagggaa ccgugauaag cc 22
<210> 9761
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9761
gugcaucagc agcccauggc cu 22
<210> 9762
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9762
gugcauguuu uaaacacaua cc 22
<210> 9763
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9763
gugccaccac ggauucagcc ag 22
<210> 9764
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9764
gugccaccgu acccagcuga uu 22
<210> 9765
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9765
gugccaucug cuguugugug uu 22
<210> 9766
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9766
gugcccaucc ucccgacccc ua 22
<210> 9767
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9767
gugcccaugc aauggcuugg gu 22
<210> 9768
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9768
gugccugaga cacccgguua cc 22
<210> 9769
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9769
gugcuccgaa accagaaagg cu 22
<210> 9770
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9770
gugcuuccac uucuaugcaa au 22
<210> 9771
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9771
guggaagcac uaggugggcg ga 22
<210> 9772
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9772
guggagagaa acucaaaacu uc 22
<210> 9773
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9773
guggagguug cagugagcca ug 22
<210> 9774
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9774
guggaugagg cagggccagg gg 22
<210> 9775
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9775
guggcaccga gaccaaacuc au 22
<210> 9776
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9776
guggcaucau uuggugaaug ag 22
<210> 9777
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9777
guggccugca cccaggugug gc 22
<210> 9778
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9778
guggcgugaa caucugccug ga 22
<210> 9779
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9779
guggcuguca ggacaccagc cu 22
<210> 9780
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9780
guggcuucug ggagaugggu gu 22
<210> 9781
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9781
guggcuuuca acacacaaca gc 22
<210> 9782
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9782
gugggaggau gguuugagcu ca 22
<210> 9783
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9783
gugggcggac auaaagacga ca 22
<210> 9784
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9784
guggggauuu uuuguuaugu uu 22
<210> 9785
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9785
guggguaggg gucgggagga ug 22
<210> 9786
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9786
gugggucaug auucgggggu ga 22
<210> 9787
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9787
guggguuugu accuuccuua ag 22
<210> 9788
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9788
guggucuccu ugcacuuucu ca 22
<210> 9789
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9789
gugguggcac cgagaccaaa cu 22
<210> 9790
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9790
gugguuuaaa aagugacacc ca 22
<210> 9791
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9791
guguacaacu cugaacugag aa 22
<210> 9792
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9792
guguaggggg uuauugccuc ug 22
<210> 9793
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9793
gugucaauga augccgggga ca 22
<210> 9794
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9794
gugucacggu ggagagaaac uc 22
<210> 9795
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9795
gugucacuuu uuaaaccacu gu 22
<210> 9796
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9796
gugucauccu gguccccccg gg 22
<210> 9797
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9797
guguccucac ggccaaggua ac 22
<210> 9798
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9798
guguccugac agccacaccu gg 22
<210> 9799
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9799
gugucucagg cacuuaauaa au 22
<210> 9800
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9800
gugucuggcc aaauucauuu uu 22
<210> 9801
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9801
gugucuuucg agguggguuu gu 22
<210> 9802
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9802
gugugcaacg cuuuuuggga ga 22
<210> 9803
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9803
guguggcugu caggacacca gc 22
<210> 9804
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9804
guguguguug ggaugggauc cc 22
<210> 9805
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9805
guguguugaa agccacuugc uu 22
<210> 9806
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9806
guguguuggg augggauccc ag 22
<210> 9807
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9807
guguuacugu ugcacugaug uc 22
<210> 9808
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9808
guguuauuau uuugcacugu uu 22
<210> 9809
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9809
guguugaaag ccacuugcuu cu 22
<210> 9810
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9810
guguugggau gggaucccag gc 22
<210> 9811
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9811
guguuuaaaa caugcacggu ga 22
<210> 9812
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9812
guguuuaccu cuucuaugca ag 22
<210> 9813
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9813
guguuuuguc ccuggggaca au 22
<210> 9814
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9814
guuaaaaauc agcuggguac gg 22
<210> 9815
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9815
guuaccuugg ccgugaggac ac 22
<210> 9816
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9816
guuacuguug cacugauguc cg 22
<210> 9817
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9817
guuagccuuu gcccugucac cc 22
<210> 9818
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9818
guuauguuug cacuuuguau au 22
<210> 9819
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9819
guuauuauuu ugcacuguuu uc 22
<210> 9820
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9820
guuauugccu cugaaaugcc uc 22
<210> 9821
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9821
guucacgcca cgucauccuc ca 22
<210> 9822
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9822
guucagaguu guacacugug ua 22
<210> 9823
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9823
guucaggagu uggagaccag gc 22
<210> 9824
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9824
guucagugac uauucucggg gc 22
<210> 9825
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9825
guucucgaua uucacgauca cg 22
<210> 9826
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9826
guucugccuc ccagaugaau aa 22
<210> 9827
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9827
guucugggca gggacgggac uc 22
<210> 9828
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9828
guucuuucug aaaucgccgu gu 22
<210> 9829
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9829
guugaaagcc acuugcuucu cu 22
<210> 9830
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9830
guugaccggg acuucaaagc cg 22
<210> 9831
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9831
guugacuccu gaguuuaggg gu 22
<210> 9832
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9832
guugaugggu auguguuuaa aa 22
<210> 9833
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9833
guugcacaca guccaguucg ug 22
<210> 9834
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9834
guugcacuga uguccggaga ga 22
<210> 9835
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9835
guugcccagg cuggaaagca gu 22
<210> 9836
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9836
guugcucagg ccuggucucc aa 22
<210> 9837
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9837
guugcuguau uuguucagug ac 22
<210> 9838
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9838
guuggagacc aggccugagc aa 22
<210> 9839
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9839
guugggaugg gaucccaggc ca 22
<210> 9840
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9840
guugggauuu ugguuucuuc cu 22
<210> 9841
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9841
guuggugcca ucugcuguug ug 22
<210> 9842
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9842
guuguacacu guguacauuu gg 22
<210> 9843
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9843
guuguaugua ugaguggcuu cu 22
<210> 9844
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9844
guuguauuuc ugaaauaggg uc 22
<210> 9845
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9845
guuguguguu gaaagccacu ug 22
<210> 9846
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9846
guuuaaaaag ugacacccau cu 22
<210> 9847
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9847
guuuaaaaca ugcacgguga gg 22
<210> 9848
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9848
guuuaccucu ucuaugcaag cc 22
<210> 9849
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9849
guuuaggggu uuggcuuaga ga 22
<210> 9850
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9850
guuucaacca auauacaaag ug 22
<210> 9851
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9851
guuucggagc acguaaaugc gu 22
<210> 9852
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9852
guuucucucc accgugacac aa 22
<210> 9853
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9853
guuucucuua uccuucacga gg 22
<210> 9854
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9854
guuucuuccu uuccucguga ag 22
<210> 9855
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9855
guuugacggg acuucagguu cu 22
<210> 9856
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9856
guuugagcuc aggcauuuga gg 22
<210> 9857
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9857
guuugaggau ugugucacgg ug 22
<210> 9858
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9858
guuugcacuu uguauauugg uu 22
<210> 9859
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9859
guuuggcuua gagauuggug ga 22
<210> 9860
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9860
guuuggucuc ggugccacca cg 22
<210> 9861
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9861
guuuguaccu uccuuaagcc ag 22
<210> 9862
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9862
guuuuaaaca cauacccauc aa 22
<210> 9863
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9863
guuuuauaua uuuauucauc ug 22
<210> 9864
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9864
guuuuauuca aagacagaga ag 22
<210> 9865
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9865
guuuucuguc guguguguug gg 22
<210> 9866
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9866
guuuugaguu ucucuccacc gu 22
<210> 9867
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9867
guuuuguccc uggggacaau ug 22
<210> 9868
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9868
guuuuuguag agaugggauc uc 22
<210> 9869
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9869
guuuuuguag ccugaauguc uu 22
<210> 9870
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9870
uaaaaaauga auuuggccag ac 22
<210> 9871
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9871
uaaaaaguga cacccaucuc cc 22
<210> 9872
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9872
uaaaaaucag cuggguacgg ug 22
<210> 9873
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9873
uaaaacaaag cucuggcagg ca 22
<210> 9874
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9874
uaaaacaagg ccggcgaggu cu 22
<210> 9875
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9875
uaaaacaugc acggugaggc cg 22
<210> 9876
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9876
uaaacacaua cccaucaacg ac 22
<210> 9877
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9877
uaaacacguu gacuccugag uu 22
<210> 9878
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9878
uaaaccacug uauagaaggu uu 22
<210> 9879
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9879
uaaacucagg agucaacgug uu 22
<210> 9880
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9880
uaaagaagag gcauuucaga gg 22
<210> 9881
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9881
uaaagacgac aauggcaguu cu 22
<210> 9882
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9882
uaaauaaauc cuccagucug ga 22
<210> 9883
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9883
uaaauauaua aaacaaagcu cu 22
<210> 9884
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9884
uaaauauuaa gggugaccag ug 22
<210> 9885
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9885
uaaauccucc agucuggauc gu 22
<210> 9886
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9886
uaaaugcguc ccuguacaga ua 22
<210> 9887
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9887
uaacaaaaaa uccccacuau cu 22
<210> 9888
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9888
uaacacaaau gccaaaugua ca 22
<210> 9889
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9889
uaacacggcg auuucagaaa ga 22
<210> 9890
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9890
uaacaguuuc aaccaauaua ca 22
<210> 9891
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9891
uaacccccua cacagggccc cg 22
<210> 9892
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9892
uaaccgggug ucucaggcac uu 22
<210> 9893
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9893
uaaccuggcu gucuagcaag gc 22
<210> 9894
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9894
uaacuuuuug guuuuuguag ag 22
<210> 9895
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9895
uaagacauuc aggcuacaaa aa 22
<210> 9896
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9896
uaagagaaac aggcccgggg gg 22
<210> 9897
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9897
uaagccaaac cccuaaacuc ag 22
<210> 9898
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9898
uaagccagga aagggauuca ug 22
<210> 9899
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9899
uaagccuuuc ugguuucgga gc 22
<210> 9900
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9900
uaaggaaggu acaaacccac cu 22
<210> 9901
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9901
uaagggugac cagugacuca gg 22
<210> 9902
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9902
uaagugccug agacacccgg uu 22
<210> 9903
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9903
uaauaaauau uaagggugac ca 22
<210> 9904
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9904
uaauaacaca aaugccaaau gu 22
<210> 9905
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9905
uaauauuuau uaagugccug ag 22
<210> 9906
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9906
uaaucauagc ucacgacagc cu 22
<210> 9907
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9907
uaauugauca caguaagaca uu 22
<210> 9908
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9908
uacaaaccca ccucgaaaga ca 22
<210> 9909
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9909
uacaaagauu auuugcacga ac 22
<210> 9910
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9910
uacaacgggg acaucauucu cc 22
<210> 9911
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9911
uacaacucug aacugagaaa gu 22
<210> 9912
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9912
uacacagggc cccgagaaua gu 22
<210> 9913
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9913
uacacagugu acaacucuga ac 22
<210> 9914
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9914
uacacugugu acauuuggca uu 22
<210> 9915
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9915
uacagauagu ggggauuuuu ug 22
<210> 9916
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9916
uacagcaacc aggguuugca aa 22
<210> 9917
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9917
uacaggcgug aggcaccugu gu 22
<210> 9918
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9918
uacagggacg cauuuacgug cu 22
<210> 9919
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9919
uacagugguu uaaaaaguga ca 22
<210> 9920
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9920
uacauacaac ggggacauca uu 22
<210> 9921
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9921
uacccacuuc cauucccgug gu 22
<210> 9922
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9922
uacccagcug auuuuuaacu uu 22
<210> 9923
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9923
uacccaucaa cgacaagauu gg 22
<210> 9924
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9924
uaccucuucu augcaagccu ug 22
<210> 9925
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9925
uaccuuccuu aagccaggaa ag 22
<210> 9926
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9926
uaccuuggcc gugaggacac gu 22
<210> 9927
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9927
uacgugcucc gaaaccagaa ag 22
<210> 9928
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9928
uacuauguug cccaggcugg aa 22
<210> 9929
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9929
uacuguugca cugauguccg ga 22
<210> 9930
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9930
uagaagaggu aaacacguug ac 22
<210> 9931
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9931
uagaagguuu uuguagccug aa 22
<210> 9932
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9932
uagaagugga agcacuaggu gg 22
<210> 9933
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9933
uagacagcca gguuagccuu ug 22
<210> 9934
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9934
uagagauugg uggaugaggc ag 22
<210> 9935
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9935
uagcaaggcu ugcauagaag ag 22
<210> 9936
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9936
uagccugaau gucuuacugu ga 22
<210> 9937
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9937
uagccuuugc ccugucaccc cc 22
<210> 9938
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9938
uagcucacga cagccucaaa ug 22
<210> 9939
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9939
uaggggguua uugccucuga aa 22
<210> 9940
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9940
uaggggucgg gaggaugggc ac 22
<210> 9941
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9941
uagggguuug gcuuagagau ug 22
<210> 9942
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9942
uaggugggcg gacauaaaga cg 22
<210> 9943
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9943
uaguaagacc ccaucucuua aa 22
<210> 9944
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9944
uagucacuga acaaauacag ca 22
<210> 9945
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9945
uagugcuucc acuucuaugc aa 22
<210> 9946
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9946
uaguggggau uuuuuguuau gu 22
<210> 9947
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9947
uaguuguauu ucugaaauag gg 22
<210> 9948
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9948
uauaaaacaa agcucuggca gg 22
<210> 9949
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9949
uauacagugg uuuaaaaagu ga 22
<210> 9950
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9950
uauagaaggu uuuuguagcc ug 22
<210> 9951
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9951
uauauaaaac aaagcucugg ca 22
<210> 9952
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9952
uauauauuua uucaucuggg ag 22
<210> 9953
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9953
uauauuuauu caucugggag gc 22
<210> 9954
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9954
uauccuucac gaggaaagga ag 22
<210> 9955
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9955
uaucgagaac ugccauuguc gu 22
<210> 9956
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9956
uaucuguaca gggacgcauu ua 22
<210> 9957
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9957
uaugaguggc uucugggaga ug 22
<210> 9958
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9958
uaugauuaug ccacugcuuu cc 22
<210> 9959
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9959
uaugcaaaug ccuccaagcc au 22
<210> 9960
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9960
uaugcaagcc uugcuagaca gc 22
<210> 9961
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9961
uaugccacug cuuuccagcc ug 22
<210> 9962
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9962
uauguacaaa gauuauuugc ac 22
<210> 9963
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9963
uauguaugag uggcuucugg ga 22
<210> 9964
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9964
uauguccgcc caccuagugc uu 22
<210> 9965
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9965
uauguguuua aaacaugcac gg 22
<210> 9966
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9966
uauuaagggu gaccagugac uc 22
<210> 9967
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9967
uauuaagugc cugagacacc cg 22
<210> 9968
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9968
uauuauuuug cacuguuuuc ug 22
<210> 9969
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9969
uauucaaaga cagagaagac ca 22
<210> 9970
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9970
uauucacgau cacggcuuug aa 22
<210> 9971
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9971
uauucaucug ggaggcagaa ca 22
<210> 9972
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9972
uauucucggg gcccugugua gg 22
<210> 9973
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9973
uauugccucu gaaaugccuc uu 22
<210> 9974
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9974
uauuuauuaa gugccugaga ca 22
<210> 9975
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9975
uauuuauuca ucugggaggc ag 22
<210> 9976
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9976
uauuuauuuu ugcaaacccu gg 22
<210> 9977
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9977
uauuucugaa auagggucuu ca 22
<210> 9978
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9978
uauuugcacg aacuggacug ug 22
<210> 9979
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9979
uauuuguuca gugacuauuc uc 22
<210> 9980
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9980
uauuuugcac uguuuucugu cg 22
<210> 9981
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9981
uauuuuugca aacccugguu gc 22
<210> 9982
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9982
ucaaaacuuc cuggagagaa au 22
<210> 9983
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9983
ucaaacaugg aagaugaaag gg 22
<210> 9984
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9984
ucaaacgauc cagacuggag ga 22
<210> 9985
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9985
ucaaagacag agaagaccaa ag 22
<210> 9986
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9986
ucaaagccgu gaucgugaau au 22
<210> 9987
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9987
ucaaaugccu gagcucaaac ca 22
<210> 9988
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9988
ucaacacaca acagcagaug gc 22
<210> 9989
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9989
ucaaccugcc ccucucuguc cc 22
<210> 9990
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9990
ucaacgacaa gauuggggaa gu 22
<210> 9991
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9991
ucaacguguu uaccucuucu au 22
<210> 9992
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9992
ucaagugauc cagcucagcc uc 22
<210> 9993
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9993
ucaaugaaug ccggggacag ag 22
<210> 9994
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9994
ucacaaggga uuggcaauug uc 22
<210> 9995
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9995
ucacaggcac gugccaccgu ac 22
<210> 9996
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9996
ucacaguaag acauucaggc ua 22
<210> 9997
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9997
ucaccaaaug augccacuuc cc 22
<210> 9998
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9998
ucacccccga aucaugaccc ac 22
<210> 9999
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 9999
ucacccuuaa uauuuauuaa gu 22
<210> 10000
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10000
ucaccgugca uguuuuaaac ac 22
<210> 10001
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10001
ucacgacagc cucaaaugcc ug 22
<210> 10002
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10002
ucacgaggaa aggaagaaac ca 22
<210> 10003
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10003
ucacgaucac ggcuuugaag uc 22
<210> 10004
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10004
ucacgccacg ucauccucca ga 22
<210> 10005
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10005
ucacgcggga gucugacgga gg 22
<210> 10006
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10006
ucacggccaa gguaaccggg ug 22
<210> 10007
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10007
ucacggcuuu gaagucccgg uc 22
<210> 10008
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10008
ucacugaaca aauacagcaa cc 22
<210> 10009
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10009
ucacugguca cccuuaauau uu 22
<210> 10010
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10010
ucacugucuc uccggacauc ag 22
<210> 10011
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10011
ucacuucccc aaucuugucg uu 22
<210> 10012
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10012
ucacuuuuua aaccacugua ua 22
<210> 10013
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10013
ucagaaagaa ccugaagucc cg 22
<210> 10014
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10014
ucagacuccc gcgugaagau gu 22
<210> 10015
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10015
ucagaggcaa uaacccccua ca 22
<210> 10016
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10016
ucagaguugu acacugugua ca 22
<210> 10017
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10017
ucagcagccc auggccucug gc 22
<210> 10018
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10018
ucagccagau cauuuccgac gc 22
<210> 10019
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10019
ucagccucgc caugccuggc ca 22
<210> 10020
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10020
ucagcugggu acgguggcac gu 22
<210> 10021
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10021
ucaggacacc agccuggugc cc 22
<210> 10022
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10022
ucaggaguca acguguuuac cu 22
<210> 10023
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10023
ucaggaguug gagaccaggc cu 22
<210> 10024
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10024
ucaggcacuu aauaaauauu aa 22
<210> 10025
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10025
ucaggcauuu gaggcugucg ug 22
<210> 10026
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10026
ucaggcccag agaagcaagu gg 22
<210> 10027
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10027
ucaggccugg ucuccaacuc cu 22
<210> 10028
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10028
ucaggcuaca aaaaccuucu au 22
<210> 10029
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10029
ucaggcucug ccucugggaa gu 22
<210> 10030
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10030
ucagguucuu ucugaaaucg cc 22
<210> 10031
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10031
ucagucugga ggaugacgug gc 22
<210> 10032
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10032
ucagugacua uucucggggc cc 22
<210> 10033
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10033
ucagugcaac aguaacacgg cg 22
<210> 10034
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10034
ucaguucaga guuguacacu gu 22
<210> 10035
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10035
ucauacauac aacggggaca uc 22
<210> 10036
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10036
ucauagcuca cgacagccuc aa 22
<210> 10037
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10037
ucauccacca aucucuaagc ca 22
<210> 10038
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10038
ucauccuggu ccccccgggc cu 22
<210> 10039
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10039
ucaucuggga ggcagaacag gc 22
<210> 10040
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10040
ucaucuucca uguuugagga uu 22
<210> 10041
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10041
ucaugaccca cccagugucu uu 22
<210> 10042
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10042
ucaugauucg ggggugacag gg 22
<210> 10043
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10043
ucauggcguc ggaaaugauc ug 22
<210> 10044
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10044
ucauucacca aaugaugcca cu 22
<210> 10045
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10045
ucauucuccc aaaaagcguu gc 22
<210> 10046
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10046
ucauugacac gggcuuuccc ug 22
<210> 10047
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10047
ucauuuccga cgccaugaau cc 22
<210> 10048
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10048
ucauuuggug aaugaguuug gu 22
<210> 10049
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10049
ucauuuuuua agagaugggg uc 22
<210> 10050
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10050
uccaacuccu gaacucaagu ga 22
<210> 10051
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10051
uccaagccau ucacuucccc aa 22
<210> 10052
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10052
uccaccaauc ucuaagccaa ac 22
<210> 10053
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10053
uccaccguga cacaauccuc aa 22
<210> 10054
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10054
uccacuucua ugcaaaugcc uc 22
<210> 10055
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10055
uccaggaagu uuugaguuuc uc 22
<210> 10056
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10056
uccaggcaga uguucacgcc ac 22
<210> 10057
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10057
uccagucugg aucguuugac gg 22
<210> 10058
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10058
uccaguucgu gcaaauaauc uu 22
<210> 10059
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10059
uccauguuug aggauugugu ca 22
<210> 10060
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10060
uccauucccg uggucuccuu gc 22
<210> 10061
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10061
uccauuucuc uccaggaagu uu 22
<210> 10062
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10062
ucccaaaaag cguugcacac ag 22
<210> 10063
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10063
ucccaacaca cacgacagaa aa 22
<210> 10064
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10064
ucccaaccca agccauugca ug 22
<210> 10065
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10065
ucccaccuca gccucgccau gc 22
<210> 10066
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10066
ucccagaagc cacucauaca ua 22
<210> 10067
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10067
ucccagaggc agagccugag uc 22
<210> 10068
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10068
ucccaggcca gggaaagccc gu 22
<210> 10069
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10069
ucccauccca acacacacga ca 22
<210> 10070
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10070
ucccaucucu acaaaaacca aa 22
<210> 10071
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10071
uccccaaucu ugucguugau gg 22
<210> 10072
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10072
uccccacuau cuguacaggg ac 22
<210> 10073
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10073
uccccaggga caaaacacug ug 22
<210> 10074
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10074
uccccccggg ccuguuucuc uu 22
<210> 10075
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10075
uccccggcau ucauugacac gg 22
<210> 10076
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10076
uccccguugu auguaugagu gg 22
<210> 10077
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10077
uccccucccc uuucaucuuc ca 22
<210> 10078
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10078
uccccuuuca ucuuccaugu uu 22
<210> 10079
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10079
ucccgacccc uacccacuuc ca 22
<210> 10080
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10080
ucccgcguga agaugucaca ag 22
<210> 10081
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10081
ucccggucaa ccugccccuc uc 22
<210> 10082
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10082
ucccgucaaa cgauccagac ug 22
<210> 10083
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10083
ucccgucccu gcccagaacc cu 22
<210> 10084
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10084
ucccgugguc uccuugcacu uu 22
<210> 10085
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10085
ucccguuggu gccaucugcu gu 22
<210> 10086
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10086
ucccugccca gaacccuucc ug 22
<210> 10087
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10087
ucccuggccu gggaucccau cc 22
<210> 10088
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10088
ucccugggga caauugccaa uc 22
<210> 10089
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10089
ucccuguaca gauagugggg au 22
<210> 10090
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10090
ucccuuguga caucuucacg cg 22
<210> 10091
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10091
ucccuuuccu ggcuuaagga ag 22
<210> 10092
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10092
uccgaaacca gaaaggcuua uc 22
<210> 10093
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10093
uccgaagccu guucugccuc cc 22
<210> 10094
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10094
uccgacgcca ugaaucccuu uc 22
<210> 10095
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10095
uccgcccacc uagugcuucc ac 22
<210> 10096
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10096
uccggacauc agugcaacag ua 22
<210> 10097
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10097
uccggagaga cagugacagc cu 22
<210> 10098
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10098
uccgucagac ucccgcguga ag 22
<210> 10099
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10099
uccguggugg caccgagacc aa 22
<210> 10100
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10100
uccucaaaca uggaagauga aa 22
<210> 10101
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10101
uccucacggc caagguaacc gg 22
<210> 10102
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10102
uccuccaguc uggaucguuu ga 22
<210> 10103
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10103
uccucccacc ucagccucgc ca 22
<210> 10104
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10104
uccucccgac cccuacccac uu 22
<210> 10105
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10105
uccucgugaa ggauaagaga aa 22
<210> 10106
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10106
uccugaacuc aagugaucca gc 22
<210> 10107
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10107
uccugacagc cacaccuggg ug 22
<210> 10108
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10108
uccugagacc ucgccggccu ug 22
<210> 10109
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10109
uccugaguuu agggguuugg cu 22
<210> 10110
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10110
uccuggagag aaauggaggu gu 22
<210> 10111
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10111
uccuggcuua aggaagguac aa 22
<210> 10112
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10112
uccugguccc cccgggccug uu 22
<210> 10113
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10113
uccuuaagcc aggaaaggga uu 22
<210> 10114
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10114
uccuucacga ggaaaggaag aa 22
<210> 10115
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10115
uccuugcacu uucucaguuc ag 22
<210> 10116
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10116
uccuuuccuc gugaaggaua ag 22
<210> 10117
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10117
ucgaaagaca cugggugggu ca 22
<210> 10118
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10118
ucgagaacug ccauugucgu cu 22
<210> 10119
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10119
ucgagguggg uuuguaccuu cc 22
<210> 10120
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10120
ucgauauuca cgaucacggc uu 22
<210> 10121
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10121
ucgaucaugg cucacugcaa cc 22
<210> 10122
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10122
ucgccaugcc uggccagagg cc 22
<210> 10123
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10123
ucgccggccu uguuuuauuc aa 22
<210> 10124
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10124
ucgccguguu acuguugcac ug 22
<210> 10125
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10125
ucgcuuuguu gcucaggccu gg 22
<210> 10126
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10126
ucggaaauga ucuggcugaa uc 22
<210> 10127
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10127
ucggacagug cccaugcaau gg 22
<210> 10128
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10128
ucggagcacg uaaaugcguc cc 22
<210> 10129
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10129
ucgggaggau gggcaccagg cu 22
<210> 10130
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10130
ucggggcccu guguaggggg uu 22
<210> 10131
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10131
ucggggguga cagggcaaag gc 22
<210> 10132
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10132
ucggugccac cacggauuca gc 22
<210> 10133
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10133
ucgucuuuau guccgcccac cu 22
<210> 10134
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10134
ucgugaagga uaagagaaac ag 22
<210> 10135
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10135
ucgugaauau cgagaacugc ca 22
<210> 10136
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10136
ucgugagcua ugauuaugcc ac 22
<210> 10137
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10137
ucgugugugu ugggauggga uc 22
<210> 10138
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10138
ucguugaugg guauguguuu aa 22
<210> 10139
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10139
ucguuugacg ggacuucagg uu 22
<210> 10140
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10140
ucuaagccaa accccuaaac uc 22
<210> 10141
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10141
ucuagcaagg cuugcauaga ag 22
<210> 10142
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10142
ucuauacagu gguuuaaaaa gu 22
<210> 10143
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10143
ucuaugcaaa ugccuccaag cc 22
<210> 10144
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10144
ucuaugcaag ccuugcuaga ca 22
<210> 10145
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10145
ucuauuuauu uuugcaaacc cu 22
<210> 10146
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10146
ucucaggaag gguucugggc ag 22
<210> 10147
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10147
ucucaggcac uuaauaaaua uu 22
<210> 10148
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10148
ucucaguuca gaguuguaca cu 22
<210> 10149
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10149
ucuccaccgu gacacaaucc uc 22
<210> 10150
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10150
ucuccaggaa guuuugaguu uc 22
<210> 10151
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10151
ucucccaaaa agcguugcac ac 22
<210> 10152
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10152
ucucccagaa gccacucaua ca 22
<210> 10153
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10153
ucuccggaca ucagugcaac ag 22
<210> 10154
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10154
ucuccuugca cuuucucagu uc 22
<210> 10155
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10155
ucucgauauu cacgaucacg gc 22
<210> 10156
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10156
ucucgcuuug uugcucaggc cu 22
<210> 10157
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10157
ucucggggcc cuguguaggg gg 22
<210> 10158
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10158
ucucggugcc accacggauu ca 22
<210> 10159
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10159
ucucuaagcc aaaccccuaa ac 22
<210> 10160
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10160
ucucuccacc gugacacaau cc 22
<210> 10161
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10161
ucucuccagg aaguuuugag uu 22
<210> 10162
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10162
ucucuccgga caucagugca ac 22
<210> 10163
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10163
ucucugggcc ugacaucccc uc 22
<210> 10164
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10164
ucucuguccc cggcauucau ug 22
<210> 10165
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10165
ucucugucuu ugaauaaaac aa 22
<210> 10166
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10166
ucucuuaaaa aaugaauuug gc 22
<210> 10167
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10167
ucucuuaucc uucacgagga aa 22
<210> 10168
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10168
ucugaaauag ggucuucauc ug 22
<210> 10169
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10169
ucugaaaucg ccguguuacu gu 22
<210> 10170
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10170
ucugaaaugc cucuucuuua ug 22
<210> 10171
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10171
ucugaacuga gaaagugcaa gg 22
<210> 10172
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10172
ucugacggag gcugucacug uc 22
<210> 10173
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10173
ucugccuccc agaugaauaa au 22
<210> 10174
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10174
ucugccucug ggaaguggca uc 22
<210> 10175
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10175
ucugccugga gucccguccc ug 22
<210> 10176
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10176
ucugcuguug uguguugaaa gc 22
<210> 10177
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10177
ucuggaggau gacguggcgu ga 22
<210> 10178
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10178
ucuggaucgu uugacgggac uu 22
<210> 10179
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10179
ucuggcaggc aaugcuuugg uc 22
<210> 10180
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10180
ucuggccaaa uucauuuuuu aa 22
<210> 10181
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10181
ucuggccagg cauggcgagg cu 22
<210> 10182
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10182
ucuggcugaa uccguggugg ca 22
<210> 10183
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10183
ucugggaagu ggcaucauuu gg 22
<210> 10184
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10184
ucugggagau gggugucacu uu 22
<210> 10185
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10185
ucugggaggc agaacaggcu uc 22
<210> 10186
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10186
ucugggcagg gacgggacuc ca 22
<210> 10187
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10187
ucugggccug acauccccuc cc 22
<210> 10188
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10188
ucugguuucg gagcacguaa au 22
<210> 10189
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10189
ucuguacagg gacgcauuua cg 22
<210> 10190
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10190
ucuguccccg gcauucauug ac 22
<210> 10191
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10191
ucugucgugu guguugggau gg 22
<210> 10192
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10192
ucugucuuug aauaaaacaa gg 22
<210> 10193
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10193
ucuuaaaaaa ugaauuuggc ca 22
<210> 10194
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10194
ucuuacuaug uugcccaggc ug 22
<210> 10195
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10195
ucuuauccuu cacgaggaaa gg 22
<210> 10196
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10196
ucuucacgcg ggagucugac gg 22
<210> 10197
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10197
ucuuccaugu uugaggauug ug 22
<210> 10198
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10198
ucuuccuuuc cucgugaagg au 22
<210> 10199
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10199
ucuucuaugc aagccuugcu ag 22
<210> 10200
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10200
ucuucucugu cuuugaauaa aa 22
<210> 10201
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10201
ucuugucguu gauggguaug ug 22
<210> 10202
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10202
ucuuuauguc cgcccaccua gu 22
<210> 10203
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10203
ucuuucgagg uggguuugua cc 22
<210> 10204
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10204
ucuuucugaa aucgccgugu ua 22
<210> 10205
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10205
ucuuugaaua aaacaaggcc gg 22
<210> 10206
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10206
ucuuuguaca uaaagaagag gc 22
<210> 10207
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10207
ugaaagccac uugcuucucu gg 22
<210> 10208
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10208
ugaaagggga ggggauguca gg 22
<210> 10209
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10209
ugaaaucgcc guguuacugu ug 22
<210> 10210
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10210
ugaaaugccu cuucuuuaug ua 22
<210> 10211
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10211
ugaacaaaua cagcaaccag gg 22
<210> 10212
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10212
ugaacaucug ccuggagucc cg 22
<210> 10213
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10213
ugaacucaag ugauccagcu ca 22
<210> 10214
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10214
ugaacugaga aagugcaagg ag 22
<210> 10215
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10215
ugaagacccu auuucagaaa ua 22
<210> 10216
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10216
ugaagauguc acaagggauu gg 22
<210> 10217
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10217
ugaaggauaa gagaaacagg cc 22
<210> 10218
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10218
ugaagucccg gucaaccugc cc 22
<210> 10219
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10219
ugaagucccg ucaaacgauc ca 22
<210> 10220
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10220
ugaauaaaac aaggccggcg ag 22
<210> 10221
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10221
ugaauaucga gaacugccau ug 22
<210> 10222
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10222
ugaaucccuu uccuggcuua ag 22
<210> 10223
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10223
ugaauccgug guggcaccga ga 22
<210> 10224
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10224
ugaaugaguu uggucucggu gc 22
<210> 10225
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10225
ugaaugccgg ggacagagag gg 22
<210> 10226
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10226
ugaauggcuu ggaggcauuu gc 22
<210> 10227
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10227
ugaauuuggc cagacacagg ug 22
<210> 10228
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10228
ugacacaauc cucaaacaug ga 22
<210> 10229
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10229
ugacacccau cucccagaag cc 22
<210> 10230
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10230
ugacaccucc auuucucucc ag 22
<210> 10231
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10231
ugacacgggc uuucccuggc cu 22
<210> 10232
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10232
ugacagccac accugggugc ag 22
<210> 10233
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10233
ugacagccuc cgucagacuc cc 22
<210> 10234
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10234
ugacagggca aaggcuaacc ug 22
<210> 10235
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10235
ugacaucccc uccccuuuca uc 22
<210> 10236
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10236
ugacaucuuc acgcgggagu cu 22
<210> 10237
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10237
ugaccaguga cucaggcucu gc 22
<210> 10238
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10238
ugacccaccc agugucuuuc ga 22
<210> 10239
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10239
ugaccgggac uucaaagccg ug 22
<210> 10240
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10240
ugacggaggc ugucacuguc uc 22
<210> 10241
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10241
ugacgggacu ucagguucuu uc 22
<210> 10242
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10242
ugacguggcg ugaacaucug cc 22
<210> 10243
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10243
ugacuauucu cggggcccug ug 22
<210> 10244
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10244
ugacucaggc ucugccucug gg 22
<210> 10245
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10245
ugacuccuga guuuaggggu uu 22
<210> 10246
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10246
ugagaaagug caaggagacc ac 22
<210> 10247
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10247
ugagacaccc gguuaccuug gc 22
<210> 10248
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10248
ugagaccucg ccggccuugu uu 22
<210> 10249
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10249
ugagcaacaa agcgagaucc ca 22
<210> 10250
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10250
ugagccacug cgcccggccu ca 22
<210> 10251
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10251
ugagcuauga uuaugccacu gc 22
<210> 10252
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10252
ugagcucagg cauuugaggc ug 22
<210> 10253
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10253
ugagcuggau cacuugaguu ca 22
<210> 10254
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10254
ugaggacacg uggccugcac cc 22
<210> 10255
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10255
ugaggauugu gucacggugg ag 22
<210> 10256
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10256
ugaggcaccu gugucuggcc aa 22
<210> 10257
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10257
ugaggcuguc gugagcuaug au 22
<210> 10258
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10258
ugagucacug gucacccuua au 22
<210> 10259
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10259
ugaguggcuu cugggagaug gg 22
<210> 10260
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10260
ugaguucagg aguuggagac ca 22
<210> 10261
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10261
ugaguuuagg gguuuggcuu ag 22
<210> 10262
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10262
ugaguuucuc uccaccguga ca 22
<210> 10263
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10263
ugaguuuggu cucggugcca cc 22
<210> 10264
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10264
ugauaagccu uucugguuuc gg 22
<210> 10265
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10265
ugaucacagu aagacauuca gg 22
<210> 10266
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10266
ugauccagcu cagccuccca aa 22
<210> 10267
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10267
ugaucgugaa uaucgagaac ug 22
<210> 10268
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10268
ugaucuggcu gaauccgugg ug 22
<210> 10269
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10269
ugaugccacu ucccagaggc ag 22
<210> 10270
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10270
ugauggguau guguuuaaaa ca 22
<210> 10271
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10271
ugaugucccc guuguaugua ug 22
<210> 10272
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10272
ugauguccgg agagacagug ac 22
<210> 10273
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10273
ugauuaugcc acugcuuucc ag 22
<210> 10274
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10274
ugauucgggg gugacagggc aa 22
<210> 10275
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10275
ugcaaacaua acaaaaaauc cc 22
<210> 10276
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10276
ugcaaacccu gguugcugua uu 22
<210> 10277
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10277
ugcaaaugcc uccaagccau uc 22
<210> 10278
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10278
ugcaacagua acacggcgau uu 22
<210> 10279
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10279
ugcaacgcuu uuugggagaa ug 22
<210> 10280
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10280
ugcaagccuu gcuagacagc ca 22
<210> 10281
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10281
ugcaaggaga ccacgggaau gg 22
<210> 10282
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10282
ugcaauggcu uggguuggga uu 22
<210> 10283
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10283
ugcacccagg uguggcuguc ag 22
<210> 10284
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10284
ugcacgaacu ggacugugug ca 22
<210> 10285
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10285
ugcacgguga ggccgggcgc ag 22
<210> 10286
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10286
ugcacugaug uccggagaga ca 22
<210> 10287
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10287
ugcacuguuu ucugucgugu gu 22
<210> 10288
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10288
ugcacuuucu caguucagag uu 22
<210> 10289
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10289
ugcacuuugu auauugguug aa 22
<210> 10290
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10290
ugcaggccac guguccucac gg 22
<210> 10291
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10291
ugcagggaac cgugauaagc cu 22
<210> 10292
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10292
ugcauagaag agguaaacac gu 22
<210> 10293
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10293
ugcauagaag uggaagcacu ag 22
<210> 10294
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10294
ugcaucagca gcccauggcc uc 22
<210> 10295
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10295
ugcaugggca cuguccgaag cc 22
<210> 10296
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10296
ugcauggugc aucagcagcc ca 22
<210> 10297
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10297
ugcauguuuu aaacacauac cc 22
<210> 10298
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10298
ugccaaaugu acacagugua ca 22
<210> 10299
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10299
ugccaauccc uugugacauc uu 22
<210> 10300
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10300
ugccaccacg gauucagcca ga 22
<210> 10301
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10301
ugccaccgua cccagcugau uu 22
<210> 10302
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10302
ugccacugcu uuccagccug gg 22
<210> 10303
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10303
ugccacuucc cagaggcaga gc 22
<210> 10304
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10304
ugccaucugc uguugugugu ug 22
<210> 10305
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10305
ugccauuguc gucuuuaugu cc 22
<210> 10306
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10306
ugcccagaac ccuuccugag ac 22
<210> 10307
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10307
ugcccaggcu ggaaagcagu gg 22
<210> 10308
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10308
ugcccauccu cccgaccccu ac 22
<210> 10309
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10309
ugcccaugca auggcuuggg uu 22
<210> 10310
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10310
ugccccucuc uguccccggc au 22
<210> 10311
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10311
ugcccuguca cccccgaauc au 22
<210> 10312
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10312
ugccggggac agagaggggc ag 22
<210> 10313
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10313
ugccucaucc accaaucucu aa 22
<210> 10314
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10314
ugccuccaag ccauucacuu cc 22
<210> 10315
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10315
ugccucugaa augccucuuc uu 22
<210> 10316
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10316
ugccucuggg aaguggcauc au 22
<210> 10317
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10317
ugccugagac acccgguuac cu 22
<210> 10318
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10318
ugccugagcu caaaccaucc uc 22
<210> 10319
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10319
ugccugccag agcuuuguuu ua 22
<210> 10320
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10320
ugccuggagu cccgucccug cc 22
<210> 10321
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10321
ugccuggcca gaggccaugg gc 22
<210> 10322
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10322
ugcgcccggc cucaccgugc au 22
<210> 10323
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10323
ugcgucccug uacagauagu gg 22
<210> 10324
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10324
ugcuagacag ccagguuagc cu 22
<210> 10325
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10325
ugcucaggcc uggucuccaa cu 22
<210> 10326
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10326
ugcuccgaaa ccagaaaggc uu 22
<210> 10327
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10327
ugcuguauuu guucagugac ua 22
<210> 10328
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10328
ugcuguugug uguugaaagc ca 22
<210> 10329
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10329
ugcuuccacu ucuaugcaaa ug 22
<210> 10330
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10330
ugcuucucug ggccugacau cc 22
<210> 10331
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10331
ugcuuuccag ccugggcaac au 22
<210> 10332
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10332
ugcuuugguc uucucugucu uu 22
<210> 10333
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10333
uggaaagcag uggcauaauc au 22
<210> 10334
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10334
uggaagauga aaggggaggg ga 22
<210> 10335
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10335
uggaagcacu aggugggcgg ac 22
<210> 10336
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10336
uggaaguggg uaggggucgg ga 22
<210> 10337
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10337
uggacugugu gcaacgcuuu uu 22
<210> 10338
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10338
uggagaccag gccugagcaa ca 22
<210> 10339
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10339
uggagagaaa cucaaaacuu cc 22
<210> 10340
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10340
uggagagaaa uggagguguc au 22
<210> 10341
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10341
uggaggauga cguggcguga ac 22
<210> 10342
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10342
uggaggcauu ugcauagaag ug 22
<210> 10343
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10343
uggagguguc auccuggucc cc 22
<210> 10344
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10344
uggagguugc agugagccau ga 22
<210> 10345
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10345
uggagucccg ucccugccca ga 22
<210> 10346
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10346
uggaucguuu gacgggacuu ca 22
<210> 10347
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10347
uggaugaggc agggccaggg gg 22
<210> 10348
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10348
uggcaauugu ccccagggac aa 22
<210> 10349
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10349
uggcaccaac gggacccccu gg 22
<210> 10350
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10350
uggcaccgag accaaacuca uu 22
<210> 10351
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10351
uggcaggcaa ugcuuugguc uu 22
<210> 10352
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10352
uggcaguucu cgauauucac ga 22
<210> 10353
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10353
uggcaucauu uggugaauga gu 22
<210> 10354
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10354
uggcauuugu guuauuauuu ug 22
<210> 10355
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10355
uggccaaauu cauuuuuuaa ga 22
<210> 10356
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10356
uggccagaca caggugccuc ac 22
<210> 10357
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10357
uggccagagg ccaugggcug cu 22
<210> 10358
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10358
uggccaggca uggcgaggcu ga 22
<210> 10359
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10359
uggcccugcc ucauccacca au 22
<210> 10360
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10360
uggccgugag gacacguggc cu 22
<210> 10361
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10361
uggccucugg ccaggcaugg cg 22
<210> 10362
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10362
uggccugcac ccaggugugg cu 22
<210> 10363
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10363
uggccuggga ucccauccca ac 22
<210> 10364
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10364
uggcgaggcu gaggugggag ga 22
<210> 10365
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10365
uggcgucgga aaugaucugg cu 22
<210> 10366
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10366
uggcgugaac aucugccugg ag 22
<210> 10367
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10367
uggcugaauc cgugguggca cc 22
<210> 10368
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10368
uggcugucag gacaccagcc ug 22
<210> 10369
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10369
uggcugucua gcaaggcuug ca 22
<210> 10370
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10370
uggcuuaagg aagguacaaa cc 22
<210> 10371
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10371
uggcuuagag auugguggau ga 22
<210> 10372
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10372
uggcuucugg gagaugggug uc 22
<210> 10373
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10373
uggcuuggag gcauuugcau ag 22
<210> 10374
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10374
uggcuugggu ugggauuuug gu 22
<210> 10375
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10375
uggcuuucaa cacacaacag ca 22
<210> 10376
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10376
ugggagaaug auguccccgu ug 22
<210> 10377
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10377
ugggagaugg gugucacuuu uu 22
<210> 10378
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10378
ugggaggaug guuugagcuc ag 22
<210> 10379
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10379
ugggaggcag aacaggcuuc gg 22
<210> 10380
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10380
ugggaggcug agcuggauca cu 22
<210> 10381
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10381
ugggauccca ggccagggaa ag 22
<210> 10382
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10382
ugggauccca ucccaacaca ca 22
<210> 10383
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10383
ugggaucucg cuuuguugcu ca 22
<210> 10384
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10384
ugggauggga ucccaggcca gg 22
<210> 10385
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10385
ugggauuuug guuucuuccu uu 22
<210> 10386
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10386
ugggcaacag augaagaccc ua 22
<210> 10387
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10387
ugggcaccag gcuggugucc ug 22
<210> 10388
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10388
ugggcacugu ccgaagccug uu 22
<210> 10389
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10389
ugggcaggga cgggacucca gg 22
<210> 10390
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10390
ugggccugac auccccuccc cu 22
<210> 10391
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10391
ugggcggaca uaaagacgac aa 22
<210> 10392
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10392
ugggcugcug augcaccaug ca 22
<210> 10393
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10393
uggggaagug aauggcuugg ag 22
<210> 10394
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10394
uggggacaau ugccaauccc uu 22
<210> 10395
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10395
uggggauuuu uuguuauguu ug 22
<210> 10396
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10396
uggguacggu ggcacgugcc ug 22
<210> 10397
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10397
uggguagggg ucgggaggau gg 22
<210> 10398
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10398
uggguaugug uuuaaaacau gc 22
<210> 10399
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10399
ugggucauga uucgggggug ac 22
<210> 10400
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10400
ugggugcagg ccacgugucc uc 22
<210> 10401
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10401
uggguggguc augauucggg gg 22
<210> 10402
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10402
ugggugucac uuuuuaaacc ac 22
<210> 10403
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10403
uggguuggga uuuugguuuc uu 22
<210> 10404
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10404
uggguuugua ccuuccuuaa gc 22
<210> 10405
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10405
uggucacccu uaauauuuau ua 22
<210> 10406
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10406
uggucagucu ggaggaugac gu 22
<210> 10407
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10407
uggucccccc gggccuguuu cu 22
<210> 10408
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10408
uggucuccuu gcacuuucuc ag 22
<210> 10409
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10409
uggucucggu gccaccacgg au 22
<210> 10410
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10410
uggucuucuc ugucuuugaa ua 22
<210> 10411
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10411
uggugaauga guuuggucuc gg 22
<210> 10412
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10412
uggugcauca gcagcccaug gc 22
<210> 10413
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10413
uggugccauc ugcuguugug ug 22
<210> 10414
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10414
uggugcccau ccucccgacc cc 22
<210> 10415
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10415
ugguggauga ggcagggcca gg 22
<210> 10416
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10416
ugguggcacc gagaccaaac uc 22
<210> 10417
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10417
ugguguccug acagccacac cu 22
<210> 10418
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10418
ugguugcugu auuuguucag ug 22
<210> 10419
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10419
ugguuuaaaa agugacaccc au 22
<210> 10420
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10420
ugguuucgga gcacguaaau gc 22
<210> 10421
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10421
ugguuucuuc cuuuccucgu ga 22
<210> 10422
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10422
ugguuugagc ucaggcauuu ga 22
<210> 10423
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10423
ugguuuuugu agagauggga uc 22
<210> 10424
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10424
uguacaaaga uuauuugcac ga 22
<210> 10425
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10425
uguacaacuc ugaacugaga aa 22
<210> 10426
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10426
uguacacagu guacaacucu ga 22
<210> 10427
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10427
uguacacugu guacauuugg ca 22
<210> 10428
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10428
uguacagaua guggggauuu uu 22
<210> 10429
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10429
uguacaggga cgcauuuacg ug 22
<210> 10430
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10430
uguacauaaa gaagaggcau uu 22
<210> 10431
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10431
uguaccuucc uuaagccagg aa 22
<210> 10432
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10432
uguagccuga augucuuacu gu 22
<210> 10433
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10433
uguagggggu uauugccucu ga 22
<210> 10434
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10434
uguauagaag guuuuuguag cc 22
<210> 10435
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10435
uguaugagug gcuucuggga ga 22
<210> 10436
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10436
uguauguaug aguggcuucu gg 22
<210> 10437
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10437
uguauuucug aaauaggguc uu 22
<210> 10438
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10438
uguauuuguu cagugacuau uc 22
<210> 10439
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10439
ugucaaugaa ugccggggac ag 22
<210> 10440
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10440
ugucacaagg gauuggcaau ug 22
<210> 10441
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10441
ugucaccccc gaaucaugac cc 22
<210> 10442
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10442
ugucacggug gagagaaacu ca 22
<210> 10443
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10443
ugucacuguc ucuccggaca uc 22
<210> 10444
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10444
ugucacuuuu uaaaccacug ua 22
<210> 10445
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10445
ugucaggaca ccagccuggu gc 22
<210> 10446
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10446
ugucaggccc agagaagcaa gu 22
<210> 10447
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10447
ugucauccug guccccccgg gc 22
<210> 10448
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10448
uguccccagg gacaaaacac ug 22
<210> 10449
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10449
uguccccggc auucauugac ac 22
<210> 10450
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10450
uguccccguu guauguauga gu 22
<210> 10451
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10451
ugucccuggg gacaauugcc aa 22
<210> 10452
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10452
uguccgaagc cuguucugcc uc 22
<210> 10453
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10453
uguccgccca ccuagugcuu cc 22
<210> 10454
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10454
uguccggaga gacagugaca gc 22
<210> 10455
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10455
uguccucacg gccaagguaa cc 22
<210> 10456
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10456
uguccugaca gccacaccug gg 22
<210> 10457
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10457
ugucgucuuu auguccgccc ac 22
<210> 10458
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10458
ugucgugagc uaugauuaug cc 22
<210> 10459
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10459
ugucgugugu guugggaugg ga 22
<210> 10460
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10460
ugucguugau ggguaugugu uu 22
<210> 10461
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10461
ugucuagcaa ggcuugcaua ga 22
<210> 10462
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10462
ugucucaggc acuuaauaaa ua 22
<210> 10463
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10463
ugucucuccg gacaucagug ca 22
<210> 10464
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10464
ugucuuucga gguggguuug ua 22
<210> 10465
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10465
ugucuuugaa uaaaacaagg cc 22
<210> 10466
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10466
ugugacaucu ucacgcggga gu 22
<210> 10467
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10467
ugugcaacgc uuuuugggag aa 22
<210> 10468
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10468
uguggcuguc aggacaccag cc 22
<210> 10469
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10469
uguguagggg guuauugccu cu 22
<210> 10470
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10470
ugugucacgg uggagagaaa cu 22
<210> 10471
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10471
ugugucuggc caaauucauu uu 22
<210> 10472
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10472
ugugugcaac gcuuuuuggg ag 22
<210> 10473
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10473
uguguguuga aagccacuug cu 22
<210> 10474
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10474
uguguguugg gaugggaucc ca 22
<210> 10475
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10475
uguguugaaa gccacuugcu uc 22
<210> 10476
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10476
uguguuggga ugggauccca gg 22
<210> 10477
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10477
uguguuuaaa acaugcacgg ug 22
<210> 10478
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10478
uguuacuguu gcacugaugu cc 22
<210> 10479
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10479
uguuauuauu uugcacuguu uu 22
<210> 10480
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10480
uguucacgcc acgucauccu cc 22
<210> 10481
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10481
uguucaguga cuauucucgg gg 22
<210> 10482
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10482
uguucugccu cccagaugaa ua 22
<210> 10483
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10483
uguugaaagc cacuugcuuc uc 22
<210> 10484
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10484
uguugcacug auguccggag ag 22
<210> 10485
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10485
uguugcucag gccuggucuc ca 22
<210> 10486
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10486
uguugggaug ggaucccagg cc 22
<210> 10487
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10487
uguugugugu ugaaagccac uu 22
<210> 10488
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10488
uguuuaaaac augcacggug ag 22
<210> 10489
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10489
uguuuaccuc uucuaugcaa gc 22
<210> 10490
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10490
uguuucucuu auccuucacg ag 22
<210> 10491
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10491
uguuugagga uugugucacg gu 22
<210> 10492
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10492
uguuugcacu uuguauauug gu 22
<210> 10493
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10493
uguuuuaaac acauacccau ca 22
<210> 10494
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10494
uguuuuauuc aaagacagag aa 22
<210> 10495
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10495
uguuuucugu cguguguguu gg 22
<210> 10496
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10496
uguuuugucc cuggggacaa uu 22
<210> 10497
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10497
uuaaaaaaug aauuuggcca ga 22
<210> 10498
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10498
uuaaaaagug acacccaucu cc 22
<210> 10499
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10499
uuaaaaauca gcuggguacg gu 22
<210> 10500
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10500
uuaaaacaug cacggugagg cc 22
<210> 10501
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10501
uuaaacacau acccaucaac ga 22
<210> 10502
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10502
uuaacuuuuu gguuuuugua ga 22
<210> 10503
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10503
uuaagccagg aaagggauuc au 22
<210> 10504
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10504
uuaaggaagg uacaaaccca cc 22
<210> 10505
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10505
uuaaggguga ccagugacuc ag 22
<210> 10506
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10506
uuaagugccu gagacacccg gu 22
<210> 10507
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10507
uuaauaaaua uuaaggguga cc 22
<210> 10508
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10508
uuaauauuua uuaagugccu ga 22
<210> 10509
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10509
uuaauugauc acaguaagac au 22
<210> 10510
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10510
uuacaggcgu gaggcaccug ug 22
<210> 10511
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10511
uuaccucuuc uaugcaagcc uu 22
<210> 10512
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10512
uuaccuuggc cgugaggaca cg 22
<210> 10513
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10513
uuacgugcuc cgaaaccaga aa 22
<210> 10514
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10514
uuacuauguu gcccaggcug ga 22
<210> 10515
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10515
uuacuguugc acugaugucc gg 22
<210> 10516
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10516
uuagagauug guggaugagg ca 22
<210> 10517
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10517
uuagccuuug cccugucacc cc 22
<210> 10518
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10518
uuagggguuu ggcuuagaga uu 22
<210> 10519
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10519
uuauauauuu auucaucugg ga 22
<210> 10520
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10520
uuauccuuca cgaggaaagg aa 22
<210> 10521
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10521
uuaugccacu gcuuuccagc cu 22
<210> 10522
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10522
uuauguccgc ccaccuagug cu 22
<210> 10523
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10523
uuauuaagug ccugagacac cc 22
<210> 10524
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10524
uuauuauuuu gcacuguuuu cu 22
<210> 10525
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10525
uuauucaaag acagagaaga cc 22
<210> 10526
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10526
uuauucaucu gggaggcaga ac 22
<210> 10527
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10527
uuauugccuc ugaaaugccu cu 22
<210> 10528
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10528
uuauuugcac gaacuggacu gu 22
<210> 10529
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10529
uuauuuugca cuguuuucug uc 22
<210> 10530
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10530
uuauuuuugc aaacccuggu ug 22
<210> 10531
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10531
uucaaagaca gagaagacca aa 22
<210> 10532
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10532
uucaaagccg ugaucgugaa ua 22
<210> 10533
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10533
uucaacacac aacagcagau gg 22
<210> 10534
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10534
uucaccaaau gaugccacuu cc 22
<210> 10535
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10535
uucacgagga aaggaagaaa cc 22
<210> 10536
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10536
uucacgauca cggcuuugaa gu 22
<210> 10537
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10537
uucacgccac gucauccucc ag 22
<210> 10538
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10538
uucacgcggg agucugacgg ag 22
<210> 10539
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10539
uucacuuccc caaucuuguc gu 22
<210> 10540
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10540
uucagaaaga accugaaguc cc 22
<210> 10541
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10541
uucagaggca auaacccccu ac 22
<210> 10542
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10542
uucagaguug uacacugugu ac 22
<210> 10543
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10543
uucagccaga ucauuuccga cg 22
<210> 10544
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10544
uucaggaguu ggagaccagg cc 22
<210> 10545
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10545
uucaggcuac aaaaaccuuc ua 22
<210> 10546
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10546
uucagguucu uucugaaauc gc 22
<210> 10547
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10547
uucagugacu auucucgggg cc 22
<210> 10548
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10548
uucaucuggg aggcagaaca gg 22
<210> 10549
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10549
uucaucuucc auguuugagg au 22
<210> 10550
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10550
uucauggcgu cggaaaugau cu 22
<210> 10551
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10551
uucauugaca cgggcuuucc cu 22
<210> 10552
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10552
uucauuuuuu aagagauggg gu 22
<210> 10553
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10553
uuccacuucu augcaaaugc cu 22
<210> 10554
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10554
uuccauguuu gaggauugug uc 22
<210> 10555
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10555
uuccauuccc guggucuccu ug 22
<210> 10556
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10556
uucccagagg cagagccuga gu 22
<210> 10557
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10557
uuccccaauc uugucguuga ug 22
<210> 10558
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10558
uucccguggu cuccuugcac uu 22
<210> 10559
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10559
uucccuggcc ugggauccca uc 22
<210> 10560
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10560
uuccgacgcc augaaucccu uu 22
<210> 10561
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10561
uuccucguga aggauaagag aa 22
<210> 10562
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10562
uuccugagac cucgccggcc uu 22
<210> 10563
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10563
uuccuggaga gaaauggagg ug 22
<210> 10564
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10564
uuccuggcuu aaggaaggua ca 22
<210> 10565
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10565
uuccuuaagc caggaaaggg au 22
<210> 10566
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10566
uuccuuuccu cgugaaggau aa 22
<210> 10567
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10567
uucgaggugg guuuguaccu uc 22
<210> 10568
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10568
uucggacagu gcccaugcaa ug 22
<210> 10569
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10569
uucggagcac guaaaugcgu cc 22
<210> 10570
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10570
uucgggggug acagggcaaa gg 22
<210> 10571
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10571
uucuauacag ugguuuaaaa ag 22
<210> 10572
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10572
uucuaugcaa augccuccaa gc 22
<210> 10573
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10573
uucuaugcaa gccuugcuag ac 22
<210> 10574
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10574
uucucaguuc agaguuguac ac 22
<210> 10575
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10575
uucucccaaa aagcguugca ca 22
<210> 10576
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10576
uucucgauau ucacgaucac gg 22
<210> 10577
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10577
uucucggggc ccuguguagg gg 22
<210> 10578
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10578
uucucuccac cgugacacaa uc 22
<210> 10579
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10579
uucucuccag gaaguuuuga gu 22
<210> 10580
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10580
uucucugggc cugacauccc cu 22
<210> 10581
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10581
uucucugucu uugaauaaaa ca 22
<210> 10582
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10582
uucucuuauc cuucacgagg aa 22
<210> 10583
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10583
uucugaaaua gggucuucau cu 22
<210> 10584
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10584
uucugaaauc gccguguuac ug 22
<210> 10585
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10585
uucugccucc cagaugaaua aa 22
<210> 10586
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10586
uucugggaga ugggugucac uu 22
<210> 10587
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10587
uucugggcag ggacgggacu cc 22
<210> 10588
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10588
uucugguuuc ggagcacgua aa 22
<210> 10589
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10589
uucugucgug uguguuggga ug 22
<210> 10590
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10590
uucuuccuuu ccucgugaag ga 22
<210> 10591
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10591
uucuuucuga aaucgccgug uu 22
<210> 10592
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10592
uugaaagcca cuugcuucuc ug 22
<210> 10593
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10593
uugaaguccc ggucaaccug cc 22
<210> 10594
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10594
uugaauaaaa caaggccggc ga 22
<210> 10595
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10595
uugacacggg cuuucccugg cc 22
<210> 10596
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10596
uugaccggga cuucaaagcc gu 22
<210> 10597
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10597
uugacgggac uucagguucu uu 22
<210> 10598
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10598
uugacuccug aguuuagggg uu 22
<210> 10599
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10599
uugagcucag gcauuugagg cu 22
<210> 10600
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10600
uugaggauug ugucacggug ga 22
<210> 10601
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10601
uugaggcugu cgugagcuau ga 22
<210> 10602
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10602
uugaguucag gaguuggaga cc 22
<210> 10603
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10603
uugaguuucu cuccaccgug ac 22
<210> 10604
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10604
uugaucacag uaagacauuc ag 22
<210> 10605
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10605
uugaugggua uguguuuaaa ac 22
<210> 10606
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10606
uugcaaaccc ugguugcugu au 22
<210> 10607
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10607
uugcacacag uccaguucgu gc 22
<210> 10608
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10608
uugcacgaac uggacugugu gc 22
<210> 10609
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10609
uugcacugau guccggagag ac 22
<210> 10610
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10610
uugcacuguu uucugucgug ug 22
<210> 10611
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10611
uugcacuuuc ucaguucaga gu 22
<210> 10612
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10612
uugcacuuug uauauugguu ga 22
<210> 10613
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10613
uugcauagaa gagguaaaca cg 22
<210> 10614
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10614
uugcauagaa guggaagcac ua 22
<210> 10615
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10615
uugcaugggc acuguccgaa gc 22
<210> 10616
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10616
uugccaaucc cuugugacau cu 22
<210> 10617
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10617
uugcccaggc uggaaagcag ug 22
<210> 10618
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10618
uugcccuguc acccccgaau ca 22
<210> 10619
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10619
uugccucuga aaugccucuu cu 22
<210> 10620
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10620
uugccugcca gagcuuuguu uu 22
<210> 10621
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10621
uugcuagaca gccagguuag cc 22
<210> 10622
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10622
uugcucaggc cuggucucca ac 22
<210> 10623
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10623
uugcuguauu uguucaguga cu 22
<210> 10624
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10624
uugcuucucu gggccugaca uc 22
<210> 10625
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10625
uuggagacca ggccugagca ac 22
<210> 10626
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10626
uuggaggcau uugcauagaa gu 22
<210> 10627
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10627
uuggcaauug uccccaggga ca 22
<210> 10628
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10628
uuggcauuug uguuauuauu uu 22
<210> 10629
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10629
uuggccagac acaggugccu ca 22
<210> 10630
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10630
uuggccguga ggacacgugg cc 22
<210> 10631
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10631
uuggcuuaga gauuggugga ug 22
<210> 10632
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10632
uugggagaau gauguccccg uu 22
<210> 10633
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10633
uugggaggcu gagcuggauc ac 22
<210> 10634
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10634
uugggauggg aucccaggcc ag 22
<210> 10635
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10635
uugggauuuu gguuucuucc uu 22
<210> 10636
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10636
uuggggaagu gaauggcuug ga 22
<210> 10637
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10637
uuggguuggg auuuugguuu cu 22
<210> 10638
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10638
uuggucucgg ugccaccacg ga 22
<210> 10639
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10639
uuggucuucu cugucuuuga au 22
<210> 10640
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10640
uuggugaaug aguuuggucu cg 22
<210> 10641
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10641
uuggugccau cugcuguugu gu 22
<210> 10642
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10642
uugguggaug aggcagggcc ag 22
<210> 10643
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10643
uugguuucuu ccuuuccucg ug 22
<210> 10644
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10644
uugguuuuug uagagauggg au 22
<210> 10645
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10645
uuguacacug uguacauuug gc 22
<210> 10646
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10646
uuguacauaa agaagaggca uu 22
<210> 10647
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10647
uuguaccuuc cuuaagccag ga 22
<210> 10648
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10648
uuguagccug aaugucuuac ug 22
<210> 10649
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10649
uuguauguau gaguggcuuc ug 22
<210> 10650
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10650
uuguauuucu gaaauagggu cu 22
<210> 10651
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10651
uuguccccag ggacaaaaca cu 22
<210> 10652
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10652
uugucccugg ggacaauugc ca 22
<210> 10653
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10653
uugucgucuu uauguccgcc ca 22
<210> 10654
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10654
uugucguuga uggguaugug uu 22
<210> 10655
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10655
uugugacauc uucacgcggg ag 22
<210> 10656
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10656
uugugucacg guggagagaa ac 22
<210> 10657
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10657
uuguguguug aaagccacuu gc 22
<210> 10658
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10658
uuguucagug acuauucucg gg 22
<210> 10659
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10659
uuguugcuca ggccuggucu cc 22
<210> 10660
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10660
uuguuuuauu caaagacaga ga 22
<210> 10661
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10661
uuuaaaaagu gacacccauc uc 22
<210> 10662
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10662
uuuaaaacau gcacggugag gc 22
<210> 10663
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10663
uuuaaacaca uacccaucaa cg 22
<210> 10664
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10664
uuuaauugau cacaguaaga ca 22
<210> 10665
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10665
uuuaccucuu cuaugcaagc cu 22
<210> 10666
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10666
uuuacgugcu ccgaaaccag aa 22
<210> 10667
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10667
uuuagggguu uggcuuagag au 22
<210> 10668
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10668
uuuauauauu uauucaucug gg 22
<210> 10669
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10669
uuuauguccg cccaccuagu gc 22
<210> 10670
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10670
uuuauuaagu gccugagaca cc 22
<210> 10671
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10671
uuuauucaaa gacagagaag ac 22
<210> 10672
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10672
uuuauucauc ugggaggcag aa 22
<210> 10673
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10673
uuuauuuuug caaacccugg uu 22
<210> 10674
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10674
uuucaacaca caacagcaga ug 22
<210> 10675
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10675
uuucagaaag aaccugaagu cc 22
<210> 10676
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10676
uuucagaggc aauaaccccc ua 22
<210> 10677
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10677
uuucaucuuc cauguuugag ga 22
<210> 10678
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10678
uuucccuggc cugggauccc au 22
<210> 10679
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10679
uuuccgacgc caugaauccc uu 22
<210> 10680
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10680
uuuccucgug aaggauaaga ga 22
<210> 10681
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10681
uuuccuggcu uaaggaaggu ac 22
<210> 10682
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10682
uuucgaggug gguuuguacc uu 22
<210> 10683
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10683
uuucggagca cguaaaugcg uc 22
<210> 10684
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10684
uuucucaguu cagaguugua ca 22
<210> 10685
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10685
uuucucucca ccgugacaca au 22
<210> 10686
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10686
uuucucucca ggaaguuuug ag 22
<210> 10687
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10687
uuucucuuau ccuucacgag ga 22
<210> 10688
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10688
uuucugaaau agggucuuca uc 22
<210> 10689
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10689
uuucugaaau cgccguguua cu 22
<210> 10690
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10690
uuucugguuu cggagcacgu aa 22
<210> 10691
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10691
uuucugucgu guguguuggg au 22
<210> 10692
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10692
uuucuuccuu uccucgugaa gg 22
<210> 10693
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10693
uuugaagucc cggucaaccu gc 22
<210> 10694
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10694
uuugaauaaa acaaggccgg cg 22
<210> 10695
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10695
uuugacggga cuucagguuc uu 22
<210> 10696
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10696
uuugagcuca ggcauuugag gc 22
<210> 10697
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10697
uuugaggauu gugucacggu gg 22
<210> 10698
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10698
uuugaggcug ucgugagcua ug 22
<210> 10699
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10699
uuugaguuuc ucuccaccgu ga 22
<210> 10700
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10700
uuugcaaacc cugguugcug ua 22
<210> 10701
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10701
uuugcacgaa cuggacugug ug 22
<210> 10702
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10702
uuugcacugu uuucugucgu gu 22
<210> 10703
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10703
uuugcacuuu guauauuggu ug 22
<210> 10704
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10704
uuugcauaga aguggaagca cu 22
<210> 10705
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10705
uuugcccugu cacccccgaa uc 22
<210> 10706
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10706
uuuggccaga cacaggugcc uc 22
<210> 10707
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10707
uuuggcuuag agauuggugg au 22
<210> 10708
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10708
uuugggagaa ugaugucccc gu 22
<210> 10709
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10709
uuugggaggc ugagcuggau ca 22
<210> 10710
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10710
uuuggucucg gugccaccac gg 22
<210> 10711
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10711
uuuggucuuc ucugucuuug aa 22
<210> 10712
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10712
uuuggugaau gaguuugguc uc 22
<210> 10713
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10713
uuugguuucu uccuuuccuc gu 22
<210> 10714
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10714
uuugguuuuu guagagaugg ga 22
<210> 10715
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10715
uuuguacaua aagaagaggc au 22
<210> 10716
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10716
uuuguaccuu ccuuaagcca gg 22
<210> 10717
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10717
uuuguagccu gaaugucuua cu 22
<210> 10718
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10718
uuugucccug gggacaauug cc 22
<210> 10719
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10719
uuuguucagu gacuauucuc gg 22
<210> 10720
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10720
uuuguugcuc aggccugguc uc 22
<210> 10721
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10721
uuuuaaacac auacccauca ac 22
<210> 10722
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10722
uuuuauucaa agacagagaa ga 22
<210> 10723
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10723
uuuucugucg uguguguugg ga 22
<210> 10724
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10724
uuuugaguuu cucuccaccg ug 22
<210> 10725
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10725
uuuugcaaac ccugguugcu gu 22
<210> 10726
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10726
uuuugcacug uuuucugucg ug 22
<210> 10727
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10727
uuuugggaga augauguccc cg 22
<210> 10728
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10728
uuuugguuuc uuccuuuccu cg 22
<210> 10729
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10729
uuuugguuuu uguagagaug gg 22
<210> 10730
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10730
uuuuguagcc ugaaugucuu ac 22
<210> 10731
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10731
uuuugucccu ggggacaauu gc 22
<210> 10732
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10732
uuuuugcaaa cccugguugc ug 22
<210> 10733
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10733
uuuuugggag aaugaugucc cc 22
<210> 10734
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10734
uuuuugguuu uuguagagau gg 22
<210> 10735
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10735
uuuuuguagc cugaaugucu ua 22
<210> 10736
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10736
uaggcuugug ggacacuaca 20
<210> 10737
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10737
gagcaacaca gagcccaggg 20
<210> 10738
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> LDLR targeting guide sequence portion
<400> 10738
gugcguugcu uugagugggu 20
<210> 10739
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> Example guide sequence portion
<400> 10739
aaaaaaaugu acuugguucc 20
<210> 10740
<211> 17
<212> RNA
<213> Artificial Sequence
<220>
<223> 17 nucleotide guide sequence 1
<400> 10740
aaaauguacu ugguucc 17
<210> 10741
<211> 17
<212> RNA
<213> Artificial Sequence
<220>
<223> 17 nucleotide guide sequence 2
<400> 10741
aaaaauguac uugguuc 17
<210> 10742
<211> 17
<212> RNA
<213> Artificial Sequence
<220>
<223> 17 nucleotide guide sequence 3
<400> 10742
aaaaaaugua cuugguu 17
<210> 10743
<211> 17
<212> RNA
<213> Artificial Sequence
<220>
<223> 17 nucleotide guide sequence 4
<400> 10743
aaaaaaaugu acuuggu 17
<210> 10744
<211> 1062
<212> PRT
<213> Artificial Sequence
<220>
<223> OMNI-79 CRISPR Nuclease
<400> 10744
Met Glu Lys Arg Leu Gly Leu Asp Ile Gly Thr Asn Ser Ile Gly Trp
1 5 10 15
Cys Leu Tyr Glu Gly Asp Ser Ile Leu Asp Ile Gly Val Arg Ile Phe
20 25 30
Ser Asp Gly Arg Asp Pro Lys Ser Gly Ala Ser Leu Ala Val Asp Arg
35 40 45
Arg Asn Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Tyr Leu Gly Arg
50 55 60
Arg Ser Ala Leu Ile Lys Ala Leu Lys Ala His Gly Leu Phe Pro Ala
65 70 75 80
Glu Gln Asp Ala Ala Lys Ala Leu Glu Arg Glu Asp Pro Tyr Ser Leu
85 90 95
Arg Val Arg Ala Leu Asp His Arg Leu Asp Pro His Gln Ile Gly Arg
100 105 110
Ala Ile Phe His Leu Asn Gln Arg Arg Gly Phe Arg Ser Asn Arg Lys
115 120 125
Ala Asp Arg Val Leu Gly Asp Gln Glu Ser Gly Leu Ile Ser Thr Ala
130 135 140
Thr Arg Val Leu Asp Glu Ala Met Ala Lys Ser Gly Ala Arg Thr Leu
145 150 155 160
Gly Glu Phe Leu Ala Ser Arg Asp Thr Arg Arg Val Arg Met Arg Pro
165 170 175
Asp Val Lys Gly Tyr Asp Phe Tyr Pro Asn Arg Gln His Tyr Leu Glu
180 185 190
Glu Phe Glu Lys Ile Trp Asp Ala Gln Ser Gln Tyr His Pro Asp Leu
195 200 205
Leu Ser Gln Gln Ala Lys Ser Ala Ile His Arg Ile Ile Phe His Gln
210 215 220
Arg Pro Leu Lys Pro Gln Ala Val Gly Thr Cys Thr Phe Ala Gly Leu
225 230 235 240
His Gly Ile Pro Gly Asp Glu Thr Arg Leu Pro Lys Ala His Pro Leu
245 250 255
Phe Gln Gln Arg Arg Leu Tyr Glu Glu Val Asn Gln Leu Glu Ile Val
260 265 270
Cys Ala Ser Ala Pro Ala Arg Lys Leu Thr Arg Asp Glu Arg Asp Ala
275 280 285
Leu Ile Leu Lys Leu Gln Asp Lys Lys Lys Val Thr Phe Ser Thr Leu
290 295 300
Ala Arg Thr Ile Arg Leu Lys Glu Gly Glu Arg Phe Asn Lys Glu Ser
305 310 315 320
Glu Asn Arg Lys Asp Leu Ala Gly Asp Glu Val Arg Ala Glu Met Ser
325 330 335
Asp Lys Thr Arg Phe Gly Arg Arg Trp Phe His Leu Ser Leu Asp Glu
340 345 350
Gln Trp Ser Val Ile Asp Arg Leu Leu Asn Glu Glu Ser Thr Glu Asp
355 360 365
Leu Leu Ala Trp Leu Glu Lys Glu Trp Ser Leu Pro Ser Asp Val Ala
370 375 380
Glu Ala Val Ala Asn Ala His Leu Pro Asp Gly His Gly Arg Phe Gly
385 390 395 400
Leu Thr Ala Thr Val Arg Leu Leu Glu His Leu Lys Ala Asp Val Val
405 410 415
Thr Tyr Ala Glu Ala Ala Arg Arg Ala Gly Phe His His Ser Asp Phe
420 425 430
Arg Asp Gly Ala Cys Tyr Asp Glu Leu Pro Tyr Tyr Gly Glu Ile Leu
435 440 445
Ser Arg Glu Ile Ala Pro Gly Lys Asp Glu Tyr Gly Asp Pro Leu Glu
450 455 460
Arg Gln Trp Gly Lys Ile Thr Asn Pro Thr Val His Ile Gly Leu Asn
465 470 475 480
Gln Leu Arg Arg Leu Ile Asn Ala Leu Val Arg Arg His Gly Arg Pro
485 490 495
Asp Phe Ile Phe Val Glu Leu Ala Arg Glu Leu Lys Leu Asn Glu Lys
500 505 510
Gln Lys Ala Asp His Lys Arg Arg Ile Lys Gln Thr Thr Asp Ala Ala
515 520 525
Arg Ala Arg Ala Glu Lys Leu Arg Glu Ile Gly Gln Arg Asp Ser Gly
530 535 540
Ser Asn Arg Met Leu Leu Arg Ile Trp Glu Glu Leu Asn Pro Ser Asn
545 550 555 560
Pro Leu Asp Arg Arg Cys Pro Tyr Cys Ala Glu Pro Ile Ser Ile Glu
565 570 575
Met Leu Met Ser Gly Ser Ala Asp Ile Asp His Ile Val Pro Tyr Ser
580 585 590
Arg Cys Leu Asp Asp Ser Ala Ala Asn Lys Val Val Ala His Asn His
595 600 605
Cys Asn Arg Gln Lys Gly Asn Arg Thr Pro Trp Glu Gln Trp Gly Gln
610 615 620
Thr Thr Arg Trp Pro Leu Ile Gln Glu Gln Val Ala Arg Met His Arg
625 630 635 640
Ser Lys Gln Trp Arg Phe Gly Pro Asp Ala Met Glu Arg Val Asp Arg
645 650 655
Asp Gly Gly Phe Ile Ala Arg Gln Leu Thr Asp Thr Gln Tyr Leu Ser
660 665 670
Arg Ile Ala Ala Gln Tyr Leu Ser Ala Leu Tyr Thr Pro Asp Glu Gly
675 680 685
Arg Arg Val Tyr Ala Val Thr Gly Arg Leu Thr Ala Met Leu Arg Arg
690 695 700
Leu Trp Gly Leu Asn Asp Ile Leu Pro Asp His Asn Trp Val Leu Asn
705 710 715 720
Pro His Ser Asn Ala Pro Lys Asn Arg Leu Asp His Arg His His Ala
725 730 735
Ile Asp Ala Ala Val Val Gly Ala Thr Thr Pro Ala Met Ile Gln Gln
740 745 750
Val Ala Arg Ala Ala Ala Arg Ala Glu Glu Gln Asp Leu Asp Arg Leu
755 760 765
Phe Ala Asp Leu Pro Pro Pro Trp Pro Gly Phe Arg Glu Glu Leu Gln
770 775 780
Gly Arg Ile Met Ala Ala Val Val Ser His Lys Pro Asp His Gly Arg
785 790 795 800
Lys Gly Arg Pro Leu Pro Gly Arg Asp Ser Thr Ser Gly Arg Leu His
805 810 815
Asn Asp Thr Ala Tyr Gly Phe Thr Gly Arg Arg Asn Ala Lys Gly Met
820 825 830
Pro Ile Val Val Thr Arg Lys Pro Leu Leu Ala Leu Lys Pro Glu Asp
835 840 845
Leu Thr Asp Pro Glu Arg Ile Pro Asp Pro Ala Leu Gln Gly Ala Leu
850 855 860
Phe Glu Ala Thr Arg Gly Ala Thr Gly Lys Asp Phe Glu Lys Ala Leu
865 870 875 880
Arg Asp Phe Ser Arg Arg Asp Gly Pro Tyr Gln Gly Ile Arg Arg Ile
885 890 895
Arg Leu Thr Glu Ala Leu Asn Val Ile Pro Ile Arg Asp Arg Thr Gly
900 905 910
His Ala Tyr Lys Gly Val Lys Gly Asp Ala Asn Ala Arg Phe Asp Val
915 920 925
Trp Arg Leu Pro Asp Gly Lys Trp Ile Thr Arg Trp Lys Asp Arg Asp
930 935 940
Gly Ile Glu His Ser Gly Ile Val Ser Leu Phe Asp Ala His Gln Pro
945 950 955 960
Ser Gln Val Tyr His Arg Pro His Pro Ala Ala Lys Lys Val Leu Ser
965 970 975
Leu Arg Gln Asn Asp Leu Val Ala Val Glu His Asp Gly Asp Pro Gly
980 985 990
Lys Ile Met Arg Val Val Lys Phe Ser Ala Asn Gly Ser Ile Thr Phe
995 1000 1005
Ala Pro His Asn Glu Ala Gly Pro Leu Lys Thr Arg Asp Thr Asp
1010 1015 1020
Pro Ala Asp Pro Phe Arg Tyr Val Thr Thr Val Ala Ser Gly Leu
1025 1030 1035
Lys Lys Met Arg Ala Arg Gln Val Arg Ile Asp Glu Leu Gly Lys
1040 1045 1050
Val His Asp Pro Gly Pro Arg Glu Asp
1055 1060
<210> 10745
<211> 1062
<212> PRT
<213> Artificial Sequence
<220>
<223> OMNI-79 V5570 CRISPR Nuclease
<400> 10745
Met Glu Lys Arg Leu Gly Leu Asp Ile Gly Thr Asn Ser Leu Gly Trp
1 5 10 15
Cys Leu Tyr Glu Gly Asp Ser Ile Leu Asp Ile Gly Val Arg Ile Phe
20 25 30
Ser Asp Gly Arg Asp Pro Lys Ser Gly Ala Ser Leu Ala Val Asp Arg
35 40 45
Arg Asn Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Tyr Leu Gly Arg
50 55 60
Arg Ser Ala Leu Ile Lys Ala Leu Lys Ala His Gly Leu Phe Pro Ala
65 70 75 80
Glu Gln Asp Ala Ala Lys Ala Leu Glu Arg Glu Asp Pro Tyr Ser Leu
85 90 95
Arg Val Arg Ala Leu Asp His Arg Leu Asp Pro His Gln Ile Gly Arg
100 105 110
Ala Ile Phe His Leu Asn Gln Arg Arg Gly Phe Arg Ser Asn Arg Lys
115 120 125
Ala Asp Arg Val Leu Gly Asp Gln Glu Ser Gly Leu Ile Ser Thr Ala
130 135 140
Thr Arg Val Leu Asp Glu Ala Met Ala Lys Ser Gly Ala Arg Thr Leu
145 150 155 160
Gly Glu Phe Leu Ala Ser Arg Asp Thr Arg Arg Val Arg Met Arg Pro
165 170 175
Asp Val Lys Gly Tyr Asp Phe Tyr Pro Asn Arg Gln His Tyr Leu Glu
180 185 190
Glu Phe Glu Lys Ile Trp Asp Ala Gln Ser Gln Tyr His Pro Asp Leu
195 200 205
Leu Ser Gln Gln Ala Lys Ser Ala Ile His Arg Ile Ile Phe His Gln
210 215 220
Arg Pro Leu Lys Pro Gln Ala Val Gly Thr Cys Thr Phe Ala Gly Leu
225 230 235 240
His Gly Ile Pro Gly Asp Glu Thr Arg Leu Pro Lys Ala His Pro Leu
245 250 255
Phe Gln Gln Arg Arg Leu Tyr Glu Glu Val Asn Gln Leu Glu Ile Val
260 265 270
Cys Ala Ser Ala Pro Ala Arg Lys Leu Thr Arg Asp Glu Arg Asp Ala
275 280 285
Leu Ile Leu Lys Leu Gln Asp Lys Lys Lys Val Thr Phe Ser Thr Leu
290 295 300
Ala Arg Thr Ile Arg Leu Lys Glu Gly Glu Arg Phe Asn Lys Glu Ser
305 310 315 320
Glu Asn Arg Lys Asp Leu Ala Gly Asp Glu Val Arg Ala Glu Met Ser
325 330 335
Asp Lys Thr Arg Phe Gly Arg Arg Trp Phe His Leu Ser Leu Asp Glu
340 345 350
Gln Trp Ser Val Ile Asp Arg Leu Leu Asn Glu Glu Ser Thr Glu Asp
355 360 365
Leu Leu Ala Trp Leu Glu Lys Glu Trp Ser Leu Pro Ser Asp Val Ala
370 375 380
Glu Ala Val Ala Asn Ala His Leu Pro Asp Gly His Gly Arg Phe Gly
385 390 395 400
Leu Thr Ala Thr Val Arg Leu Leu Glu His Leu Lys Ala Asp Val Val
405 410 415
Thr Tyr Ala Glu Ala Ala Arg Arg Ala Gly Phe His His Ser Asp Phe
420 425 430
Arg Asp Gly Ala Cys Tyr Asp Glu Leu Pro Tyr Tyr Gly Glu Ile Leu
435 440 445
Ser Arg Glu Ile Ala Pro Gly Lys Asp Glu Tyr Gly Asp Pro Leu Glu
450 455 460
Arg Gln Trp Gly Lys Ile Thr Asn Pro Thr Val His Ile Gly Leu Asn
465 470 475 480
Gln Leu Arg Arg Leu Ile Asn Ala Leu Val Arg Arg His Gly Arg Pro
485 490 495
Asp Phe Ile Phe Val Glu Leu Ala Arg Glu Leu Lys Leu Asn Glu Lys
500 505 510
Gln Lys Ala Asp His Lys Arg Arg Ile Lys Gln Thr Thr Asp Ala Ala
515 520 525
Arg Ala Arg Ala Glu Lys Leu Arg Glu Ile Gly Gln Arg Asp Ser Gly
530 535 540
Ser Asn Arg Met Leu Leu Arg Ile Trp Glu Glu Leu Asn Pro Ser Asn
545 550 555 560
Pro Leu Asp Arg Arg Cys Pro Tyr Cys Ala Glu Pro Ile Ser Ile Glu
565 570 575
Met Leu Met Ser Gly Ser Ala Asp Ile Asp His Ile Val Pro Tyr Ser
580 585 590
Arg Cys Leu Asp Asp Ser Ala Ala Asn Lys Val Val Ala His Asn His
595 600 605
Cys Asn Arg Gln Lys Gly Asn Arg Thr Pro Trp Glu Gln Trp Gly Gln
610 615 620
Thr Thr Arg Trp Pro Leu Ile Gln Glu Gln Val Ala Arg Met His Arg
625 630 635 640
Ser Lys Gln Trp Arg Phe Gly Pro Asp Ala Met Glu Arg Val Asp Arg
645 650 655
Asp Gly Gly Phe Ile Ala Arg Gln Leu Thr Asp Thr Gln Tyr Leu Ser
660 665 670
Arg Ile Ala Ala Gln Tyr Leu Ser Ala Leu Tyr Thr Pro Asp Glu Gly
675 680 685
Arg Arg Val Tyr Ala Val Thr Gly Arg Leu Thr Ala Met Leu Arg Arg
690 695 700
Leu Trp Gly Leu Asn Asp Ile Leu Pro Asp His Asn Trp Val Leu Asn
705 710 715 720
Pro His Ser Asn Ala Pro Lys Asn Arg Leu Asp His Arg His His Ala
725 730 735
Ile Asp Ala Ala Val Val Gly Ala Thr Thr Pro Ala Met Ile Gln Gln
740 745 750
Val Ala Arg Ala Ala Ala Arg Ala Glu Glu Gln Asp Leu Asp Arg Leu
755 760 765
Phe Ala Asp Leu Pro Pro Pro Trp Pro Gly Phe Arg Glu Glu Leu Gln
770 775 780
Gly Arg Ile Met Ala Ala Val Val Ser His Lys Pro Asp His Gly Arg
785 790 795 800
Lys Gly Arg Pro Leu Pro Gly Arg Asp Ser Thr Ser Gly Arg Leu His
805 810 815
Asn Asp Thr Ala Tyr Gly Phe Thr Gly Arg Arg Asn Ala Lys Gly Met
820 825 830
Pro Ile Val Val Thr Arg Lys Pro Leu Leu Ala Leu Lys Pro Glu Asp
835 840 845
Leu Thr Asp Pro Glu Arg Ile Pro Asp Pro Ala Leu Gln Gly Ala Leu
850 855 860
Phe Glu Ala Thr Arg Gly Ala Thr Gly Lys Asp Phe Glu Lys Ala Leu
865 870 875 880
Arg Asp Phe Ser Arg Arg Asp Gly Pro Tyr Gln Gly Ile Arg Arg Ile
885 890 895
Arg Leu Thr Glu Ala Leu Asn Val Ile Pro Ile Arg Asp Arg Thr Gly
900 905 910
His Ala Tyr Lys Gly Val Lys Gly Asp Ala Asn Ala Arg Phe Asp Val
915 920 925
Trp Arg Leu Pro Asp Gly Lys Trp Ile Thr Arg Trp Lys Asp Arg Asp
930 935 940
Gly Ile Glu His Ser Gly Ile Val Ser Leu Phe Asp Ala His Gln Pro
945 950 955 960
Ser Gln Val Tyr His Arg Pro His Pro Ala Ala Lys Lys Val Leu Ser
965 970 975
Leu Arg Gln Asn Asp Leu Val Ala Val Glu His Asp Gly Asp Pro Gly
980 985 990
Lys Ile Met Arg Val Val Lys Phe Ser Ala Asn Gly Arg Ile Thr Phe
995 1000 1005
Ala Pro His Asn Glu Ala Gly Pro Leu Lys Thr Arg Asp Thr Asp
1010 1015 1020
Pro Ala Asp Pro Phe Arg Tyr Val Thr Thr Val Ala Ser Gly Leu
1025 1030 1035
Lys Lys Met Arg Ala Arg Gln Val Arg Ile Asp Glu Leu Gly Lys
1040 1045 1050
Val His Asp Pro Gly Pro Arg Glu Asp
1055 1060
<210> 10746
<211> 1348
<212> PRT
<213> Artificial Sequence
<220>
<223> OMNI-103 CRISPR Nuclease
<400> 10746
Met Ser Ile Lys Ser Asp Tyr Phe Leu Gly Leu Asp Ile Gly Thr Asp
1 5 10 15
Ser Ile Gly Trp Ala Val Thr Asp Pro Glu Tyr His Ile Leu Arg Arg
20 25 30
Lys Gly Lys Ala Leu Trp Gly Ile Arg Leu Phe Asp Ala Ala Asn Thr
35 40 45
Ala Ala Glu Arg Arg Thr Phe Arg Thr Ser Arg Arg Arg Ile Gln Arg
50 55 60
Arg Arg Gln Arg Ile Arg Leu Leu Gln Glu Leu Phe Ala Glu Glu Met
65 70 75 80
Val Lys Leu Asp Pro Gly Phe Phe Gln Arg Leu Ser Asp Ser Ala Phe
85 90 95
Trp Gln Glu Asp Lys Gln Glu Gln Gln Ile Tyr Ser Leu Phe Thr Cys
100 105 110
Glu Asn Tyr Thr Asp Val Asp Tyr Tyr Arg Glu Tyr Pro Thr Ile Tyr
115 120 125
His Leu Arg Ser Ala Leu Ile Gln Glu Lys Lys Glu Phe Asp Leu Arg
130 135 140
Leu Leu Tyr Leu Ala Leu His His Leu Met Lys His Arg Gly His Phe
145 150 155 160
Leu Phe Asn Gly Ser Ile Asn Asn Val Thr Ser Phe His Thr Thr Phe
165 170 175
Gln Thr Phe Ala Asp Cys Leu Tyr Asp Glu Phe Asp Ile Glu Leu Glu
180 185 190
Cys Asp Ser Glu Asp Arg Phe Ala Glu Ile Leu Lys Asp Lys His Ala
195 200 205
Arg Lys Thr Gly Lys Cys Ser Glu Leu Glu Ile Ile Cys His Ile Glu
210 215 220
Lys Ser Asn Lys Gln Leu Lys Glu Leu Phe Lys Leu Ile Thr Gly Met
225 230 235 240
Lys Ala Ser Leu Ser Val Val Phe Gly Asp Asp Glu Leu Ala Glu Ile
245 250 255
Glu His Asn Lys Ile Ser Phe Ser Glu Ser Ser Tyr Asp Glu Val Arg
260 265 270
Leu Ala Leu Glu Asp Glu Ile Gln Glu Arg Thr Gly Ile Leu Asp Ile
275 280 285
Phe His Ala Val Tyr Ser Trp Ala Ile Leu Ala Asp Ile Leu Glu Gly
290 295 300
Gly Glu Tyr Glu Gly Asn Ser Tyr Leu Ser Val Ala Lys Val Ser Thr
305 310 315 320
Tyr Lys Lys His Gly Asp Asp Leu Arg Leu Leu Arg Thr Leu Val Arg
325 330 335
Glu Tyr Cys Pro Asp His Tyr Lys Ser Phe Phe Ser Val Ser Gly Lys
340 345 350
Glu Asn Tyr Cys Ala Tyr Ala Gly Thr Leu Lys Lys Asn Gly Lys Lys
355 360 365
Gln Pro Ile Lys Arg Cys Ser Gln Glu Asp Phe Tyr Lys Ala Leu Lys
370 375 380
Lys Leu Leu Asn Gln Met Pro Thr Glu Gln Pro Glu Val Lys Asp Ile
385 390 395 400
Phe Ile Glu Ile Glu Asn Gly Thr Phe Leu Pro Leu Gln Val Ser Lys
405 410 415
Asp Asn Gly Val Ile Pro Tyr Gln Val Asn Lys Met Glu Leu Glu Lys
420 425 430
Ile Leu Gln Asn Ala Glu Glu Tyr Leu Pro Phe Leu Lys Asn Ile Asp
435 440 445
Glu Glu Cys Gly Lys Thr Val Ser Lys Lys Ile Ile Asp Leu Phe Glu
450 455 460
Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Thr Ala Lys Gly Glu
465 470 475 480
Asn Cys Trp Met Val Arg Lys Glu Ala Gly Arg Ile Tyr Pro Trp Asn
485 490 495
Phe Asp Glu Lys Val Asp Arg Asp Gln Ser Ala Glu Lys Phe Ile Arg
500 505 510
Arg Met Thr Asn Gln Cys Thr Tyr Leu Ile His Glu Asp Val Val Pro
515 520 525
Lys Asn Ser Leu Leu Tyr Ser Glu Phe Met Val Leu Asn Glu Leu Asn
530 535 540
Asn Val Lys Ile Arg Ser Glu Lys Leu Pro Val Glu Leu Lys Gln Ala
545 550 555 560
Ile Val Leu Asp Leu Phe Lys Lys Gln Lys Gln Ile Thr Gly Lys Lys
565 570 575
Leu Leu Asn Tyr Leu Asn Ala Asn Gly Tyr Asp Val Lys Lys Glu Asp
580 585 590
Leu Ser Gly Phe Asp Gly Asn Phe Lys Ser Ser Leu Ser Ser Tyr Leu
595 600 605
Thr Leu Lys Lys Val Phe Gly Glu Glu Leu Asp Lys Tyr Ser Val Gln
610 615 620
Gln Met Ala Glu Asp Ile Ile Leu Trp Ile Thr Leu Tyr Gly Asp Asp
625 630 635 640
Gln Lys Met Leu Arg Arg Val Ile Arg Lys His Tyr Glu Gln Gln Leu
645 650 655
Ser Glu Glu Gln Ile Leu Ser Leu Ser Lys Leu Lys Phe Gln Gly Trp
660 665 670
Gly Arg Leu Ser Arg Arg Leu Leu Ser Glu Met Glu Gly Val Asp Cys
675 680 685
Glu Thr Gly Glu Cys Met Thr Val Met Gln Gly Leu Arg Asn Thr Gln
690 695 700
Asn Asn Leu Met Gln Leu Leu Ser Gln Gln Phe Ser Phe Met Glu Leu
705 710 715 720
Ile Glu Glu Glu Asn Gly Asn Tyr Tyr Val Asp Glu Ile Thr Tyr Asp
725 730 735
Asn Leu Val Lys Asp Met Val Ile Ser Pro Ser Val Lys Arg Ala Val
740 745 750
Trp Gln Thr Val Gln Ile Val Glu Glu Ile Lys Gly Val Met Gly Cys
755 760 765
Gln Pro Lys Lys Ile Phe Val Glu Met Ala Arg Ser Asp Glu Glu Lys
770 775 780
Lys Arg Thr Val Ser Arg Lys Asp Arg Leu Leu Glu Ala Tyr Asp Ala
785 790 795 800
Ile Lys Asp Glu Ala Arg Gln Trp Gln Glu Glu Leu Gln Lys Tyr Ser
805 810 815
Asp Gly Asp Phe Lys Ala Ile Lys Leu Tyr Leu Tyr Tyr Thr Gln Met
820 825 830
Gly Gln Cys Met Tyr Thr Gly Arg Lys Ile Asp Leu Ser Gln Leu Asn
835 840 845
Asp Ala Thr Val Trp Asp Arg Asp His Ile Tyr Pro Gln Ser Lys Thr
850 855 860
Lys Asp Asp Ser Leu Asp Asn Leu Val Leu Val Asp Arg Ser Val Asn
865 870 875 880
Ala Lys Lys Ser Asp Gly Met Leu Ser Pro Glu Ile Gln Gln Arg Met
885 890 895
Arg Ala Thr Trp Lys Tyr Leu Lys Glu Lys Lys Leu Ile Ser Glu Lys
900 905 910
Lys Tyr Glu Arg Leu Thr Arg Val Ser Pro Leu Thr Asp Glu Glu Leu
915 920 925
Ala Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Ser Lys
930 935 940
Ala Val Ala Thr Leu Leu Lys Arg Val Tyr Asp Glu Ala Glu Ile Val
945 950 955 960
Tyr Val Lys Ala Glu Ala Val Ser Asn Phe Arg Arg Asp Asn Leu Asp
965 970 975
Tyr Ile Lys Val Arg Asp Leu Asn Asp Tyr His His Ala Lys Asp Ala
980 985 990
Tyr Gln Asn Ile Val Val Gly Asn Val Phe His Glu Lys Phe Thr Ser
995 1000 1005
Asn Pro Leu Arg Trp Leu Lys Asn Asn Pro Asn Thr Lys Tyr Ser
1010 1015 1020
Leu Asn Gln Met Phe Asn Phe Asp Leu Glu Lys Asn Gly Val Val
1025 1030 1035
Ile Trp Lys Arg Gly Lys Ala Gly Ser Ile Lys Cys Val Glu Glu
1040 1045 1050
Thr Leu Lys Arg Asn Asp Ile Leu Phe Thr Arg Tyr Ala Phe Cys
1055 1060 1065
Asn Lys Gly Gly Phe Phe Asn Gln Met Leu Thr Ala Ala Pro Glu
1070 1075 1080
Asp Lys Thr Lys Ala Lys Gly Leu Val Pro Ile Lys Lys Gly Met
1085 1090 1095
Glu Thr Trp Lys Tyr Gly Gly Tyr Thr Ser Val Thr Pro Ser His
1100 1105 1110
Phe Met Leu Val Ala Ser Lys Asp Lys Lys Gly Lys Glu Ile Arg
1115 1120 1125
Thr Ile Glu Thr Val Pro Leu Tyr Arg Trp Lys Glu Phe Lys Glu
1130 1135 1140
Asn Pro Asp Ala Leu Leu Gln Tyr Cys Arg Glu Phe Tyr Gly Leu
1145 1150 1155
Lys Glu Pro Lys Val Leu Ile Pro Cys Ile Lys Lys Asn Ala Arg
1160 1165 1170
Leu Val Val Asn Gly Phe Pro Met His Leu Lys Gly Ser Thr Gly
1175 1180 1185
Lys Gln Leu Ile Leu Gln Gly Ala Val Gln Leu Cys Leu Asn Asn
1190 1195 1200
Glu Asn Ile Lys Tyr Leu Lys Lys Val Thr Lys Tyr Leu Glu Tyr
1205 1210 1215
Asn Ala Gln Arg Arg Asp Lys Arg Thr Leu Leu Glu Val Arg Glu
1220 1225 1230
Val Thr Gly Ile Asn Lys Glu Glu Asn Ile Gln Leu Tyr Asp Val
1235 1240 1245
Phe Val Asp Lys Leu Ser Asn Thr Ile Tyr Gln Tyr Arg Pro Ala
1250 1255 1260
Asn Pro Lys Asp Asn Leu Ile Lys Gly Arg Glu Lys Phe Ile Glu
1265 1270 1275
Leu Gly Leu Ala Glu Gln Cys Val Val Leu Gly Glu Val Leu His
1280 1285 1290
Leu Phe Gln Cys Lys Pro Leu Thr Ser Asp Leu Thr Leu Ile Gly
1295 1300 1305
Gly Ser Pro Asn Thr Gly Thr Ile Lys Ile Thr Lys Thr Ile Ser
1310 1315 1320
Asn Cys Asn Val Val Lys Leu Leu Ser Gln Ser Ile Ala Gly Val
1325 1330 1335
Lys Val Arg Glu Ile Asn Leu Leu Ile Ile
1340 1345
<210> 10747
<211> 74
<212> RNA
<213> Artificial Sequence
<220>
<223> OMNI-79 and OMNI-79 V5570 sgRNA scaffold
<400> 10747
guugccgcug gagaaaucca guuguuaaca agcagcuuga cugcaccaaa uaaggcgggg 60
gcugcggccc ucgc 74
<210> 10748
<211> 107
<212> RNA
<213> Artificial Sequence
<220>
<223> OMNI-103 sgRNA scaffold
<400> 10748
guuugagagu aguguaagaa auuacacuac aaguucaaau aaaaauuuau ucaaauccau 60
uugcuacauu guguagaauu uaaagaucug gcaacagauc uuuuuuu 107
<210> 10749
<211> 1370
<212> PRT
<213> Ezakiella peruensis strain M6.X2
<400> 10749
Met Thr Lys Val Lys Asp Tyr Tyr Ile Gly Leu Asp Ile Gly Thr Ser
1 5 10 15
Ser Val Gly Trp Ala Val Thr Asp Glu Ala Tyr Asn Val Leu Lys Phe
20 25 30
Asn Ser Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr
35 40 45
Ala Glu Glu Arg Arg Gly Gln Arg Gly Ala Arg Arg Arg Leu Asp Arg
50 55 60
Lys Lys Glu Arg Leu Ser Leu Leu Gln Asp Phe Phe Ala Glu Glu Val
65 70 75 80
Ala Lys Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu
85 90 95
Tyr Met Glu Asp Lys Asp Gln Lys Leu Lys Ser Lys Tyr Thr Leu Phe
100 105 110
Asn Asp Lys Asp Phe Lys Asp Lys Asn Phe His Lys Lys Tyr Pro Thr
115 120 125
Ile His His Leu Leu Met Asp Leu Ile Glu Asp Asp Ser Lys Lys Asp
130 135 140
Ile Arg Leu Val Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly
145 150 155 160
His Phe Ile Phe Glu Gly Gln Lys Phe Asp Thr Lys Ser Ser Phe Glu
165 170 175
Asn Ser Leu Asn Glu Leu Lys Val His Leu Asn Asp Glu Tyr Gly Leu
180 185 190
Asp Leu Glu Phe Asp Asn Glu Asn Leu Ile Asn Ile Leu Thr Asp Pro
195 200 205
Lys Leu Asn Lys Thr Ala Lys Lys Lys Glu Leu Lys Ser Val Ile Gly
210 215 220
Asp Thr Lys Phe Leu Lys Ala Val Ser Ala Ile Met Ile Gly Ser Ser
225 230 235 240
Gln Lys Leu Val Asp Leu Phe Glu Asn Pro Glu Asp Phe Asp Asp Ser
245 250 255
Ala Ile Lys Ser Val Asp Phe Ser Thr Thr Ser Phe Asp Asp Lys Tyr
260 265 270
Ser Asp Tyr Glu Leu Ala Leu Gly Asp Lys Ile Ala Leu Val Asn Ile
275 280 285
Leu Lys Glu Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Glu
290 295 300
Ala Asp Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Asn Ala Phe Val
305 310 315 320
Lys Lys Tyr Asn Lys His Gly Gln Asp Leu Lys Glu Phe Lys Arg Leu
325 330 335
Val Arg Gln Tyr His Lys Ser Ala Tyr Phe Asp Ile Phe Arg Ser Glu
340 345 350
Lys Val Asn Asp Asn Tyr Val Ser Tyr Thr Lys Ser Ser Ile Ser Asn
355 360 365
Asn Lys Arg Val Lys Ala Asn Lys Phe Thr Asp Gln Glu Ala Phe Tyr
370 375 380
Lys Phe Ala Lys Lys His Leu Glu Thr Ile Lys Tyr Lys Ile Asn Lys
385 390 395 400
Val Asn Gly Ser Lys Ala Asp Leu Glu Leu Ile Asp Gly Met Leu Arg
405 410 415
Asp Met Glu Phe Lys Asn Phe Met Pro Lys Ile Lys Ser Ser Asp Asn
420 425 430
Gly Val Ile Pro Tyr Gln Leu Lys Leu Met Glu Leu Asn Lys Ile Leu
435 440 445
Glu Asn Gln Ser Lys His His Glu Phe Leu Asn Val Ser Asp Glu Tyr
450 455 460
Gly Ser Val Cys Asp Lys Ile Ala Ser Ile Met Glu Phe Arg Ile Pro
465 470 475 480
Tyr Tyr Val Gly Pro Leu Asn Pro Asn Ser Lys Tyr Ala Trp Ile Lys
485 490 495
Lys Gln Lys Asp Ser Glu Ile Thr Pro Trp Asn Phe Lys Asp Val Val
500 505 510
Asp Leu Asp Ser Ser Arg Glu Glu Phe Ile Asp Ser Leu Ile Gly Arg
515 520 525
Cys Thr Tyr Leu Lys Asp Glu Lys Val Leu Pro Lys Ala Ser Leu Leu
530 535 540
Tyr Asn Glu Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn
545 550 555 560
Asp Leu Pro Ile Thr Glu Glu Met Lys Lys Lys Ile Phe Asp Gln Leu
565 570 575
Phe Lys Thr Arg Lys Lys Val Thr Leu Lys Ala Val Ala Asn Leu Leu
580 585 590
Lys Lys Glu Phe Asn Ile Asn Gly Glu Ile Leu Leu Ser Gly Thr Asp
595 600 605
Gly Asp Phe Lys Gln Gly Leu Asn Ser Tyr Asn Asp Phe Lys Ala Ile
610 615 620
Val Gly Asp Lys Val Asp Ser Asp Asp Tyr Arg Asp Lys Ile Glu Glu
625 630 635 640
Ile Ile Lys Leu Ile Val Leu Tyr Gly Asp Asp Lys Ser Tyr Leu Gln
645 650 655
Lys Lys Ile Lys Ala Gly Tyr Gly Lys Tyr Phe Thr Asp Ser Glu Ile
660 665 670
Lys Lys Met Ala Gly Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys
675 680 685
Lys Leu Leu Thr Gly Leu Glu Gly Ala Asn Lys Ile Thr Gly Glu Arg
690 695 700
Gly Ser Ile Ile His Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu
705 710 715 720
Leu Met Ser Ala Ser Phe Thr Phe Thr Glu Glu Ile Gln Lys Leu Asn
725 730 735
Pro Val Asp Asp Arg Lys Leu Ser Tyr Glu Met Val Asp Glu Leu Tyr
740 745 750
Leu Ser Pro Ser Val Lys Arg Met Leu Trp Gln Ser Leu Arg Ile Val
755 760 765
Asp Glu Ile Lys Asn Ile Met Gly Thr Asp Ser Lys Lys Ile Phe Ile
770 775 780
Glu Met Ala Arg Gly Lys Glu Glu Val Lys Ala Arg Lys Glu Ser Arg
785 790 795 800
Lys Asn Gln Leu Leu Lys Phe Tyr Lys Asp Gly Lys Lys Ala Phe Ile
805 810 815
Ser Glu Ile Gly Glu Glu Arg Tyr Ser Tyr Leu Leu Ser Glu Ile Glu
820 825 830
Gly Glu Glu Glu Asn Lys Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr
835 840 845
Thr Gln Leu Gly Arg Cys Met Tyr Ser Leu Glu Pro Ile Asp Ile Ser
850 855 860
Glu Leu Ser Ser Lys Asn Ile Tyr Asp Gln Asp His Ile Tyr Pro Lys
865 870 875 880
Ser Lys Ile Tyr Asp Asp Ser Ile Glu Asn Arg Val Leu Val Lys Lys
885 890 895
Asp Leu Asn Ser Lys Lys Gly Asn Ser Tyr Pro Ile Pro Asp Glu Ile
900 905 910
Leu Asn Lys Asn Cys Tyr Ala Tyr Trp Lys Ile Leu Tyr Asp Lys Gly
915 920 925
Leu Ile Gly Gln Lys Lys Tyr Thr Arg Leu Thr Arg Arg Thr Gly Phe
930 935 940
Thr Asp Asp Glu Leu Val Gln Phe Ile Ser Arg Gln Ile Val Glu Thr
945 950 955 960
Arg Gln Ala Thr Lys Glu Thr Ala Asn Leu Leu Lys Thr Ile Cys Lys
965 970 975
Asn Ser Glu Ile Val Tyr Ser Lys Ala Glu Asn Ala Ser Arg Phe Arg
980 985 990
Gln Glu Phe Asp Ile Val Lys Cys Arg Ala Val Asn Asp Leu His His
995 1000 1005
Met His Asp Ala Tyr Ile Asn Ile Ile Val Gly Asn Val Tyr Asn
1010 1015 1020
Thr Lys Phe Thr Lys Asp Pro Met Asn Phe Val Lys Lys Gln Glu
1025 1030 1035
Lys Ala Arg Ser Tyr Asn Leu Glu Asn Met Phe Lys Tyr Asp Val
1040 1045 1050
Lys Arg Gly Gly Tyr Thr Ala Trp Ile Ala Asp Asp Glu Lys Gly
1055 1060 1065
Thr Val Lys Asn Ala Ser Ile Lys Arg Ile Arg Lys Glu Leu Glu
1070 1075 1080
Gly Thr Asn Tyr Arg Phe Thr Arg Met Asn Tyr Ile Glu Ser Gly
1085 1090 1095
Ala Leu Phe Asn Ala Thr Leu Gln Arg Lys Asn Lys Gly Ser Arg
1100 1105 1110
Pro Leu Lys Asp Lys Gly Pro Lys Ser Ser Ile Glu Lys Tyr Gly
1115 1120 1125
Gly Tyr Thr Asn Ile Asn Lys Ala Cys Phe Ala Val Leu Asp Ile
1130 1135 1140
Lys Ser Lys Asn Lys Ile Glu Arg Lys Leu Met Pro Val Glu Arg
1145 1150 1155
Glu Ile Tyr Ala Lys Gln Lys Asn Asp Lys Lys Leu Ser Asp Glu
1160 1165 1170
Ile Phe Ser Lys Tyr Leu Lys Asp Arg Phe Gly Ile Glu Asp Tyr
1175 1180 1185
Arg Val Val Tyr Pro Val Val Lys Met Arg Thr Leu Leu Lys Ile
1190 1195 1200
Asp Gly Ser Tyr Tyr Phe Ile Thr Gly Gly Ser Asp Lys Thr Leu
1205 1210 1215
Glu Leu Arg Ser Ala Leu Gln Leu Ile Leu Pro Lys Lys Asn Glu
1220 1225 1230
Trp Ala Ile Lys Gln Ile Asp Lys Ser Ser Glu Asn Asp Tyr Leu
1235 1240 1245
Thr Ile Glu Arg Ile Gln Asp Leu Thr Glu Glu Leu Val Tyr Asn
1250 1255 1260
Thr Phe Asp Ile Ile Val Asn Lys Phe Lys Thr Ser Val Phe Lys
1265 1270 1275
Lys Ser Phe Leu Asn Leu Phe Gln Asp Asp Lys Ile Glu Asn Ile
1280 1285 1290
Asp Phe Lys Phe Lys Ser Met Asp Phe Lys Glu Lys Cys Lys Thr
1295 1300 1305
Leu Leu Met Leu Val Lys Ala Ile Arg Ala Ser Gly Val Arg Gln
1310 1315 1320
Asp Leu Lys Ser Ile Asp Leu Lys Ser Asp Tyr Gly Arg Leu Ser
1325 1330 1335
Ser Lys Thr Asn Asn Ile Gly Asn Tyr Gln Glu Phe Lys Ile Ile
1340 1345 1350
Asn Gln Ser Ile Thr Gly Leu Phe Glu Asn Glu Val Asp Leu Leu
1355 1360 1365
Lys Leu
1370
<210> 10750
<211> 112
<212> RNA
<213> Artificial Sequence
<220>
<223> OMNI-50 sgRNA Scaffold
<400> 10750
guuugagagu uauguaagaa auuacaugac gaguucaaau aaaaauuuau ucaaaccgcc 60
uauuuauagg ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu 112
<210> 10751
<211> 18
<212> DNA
<213> Homo sapiens
<400> 10751
gctgtgatgg tggccccg 18
<210> 10752
<211> 6
<212> PRT
<213> Homo sapiens
<400> 10752
Arg Cys Asp Gly Gly Pro
1 5
<210> 10753
<211> 34
<212> DNA
<213> Homo sapiens
<400> 10753
gctggcgctg tgatggtggc cccgactgca agga 34
<210> 10754
<211> 34
<212> DNA
<213> Homo sapiens
<400> 10754
cgaccgcgac actaccaccg gggctgacgt tcct 34
<210> 10755
<211> 16
<212> DNA
<213> Homo sapiens
<400> 10755
agtgaactgg tgtgag 16
<210> 10756
<211> 5
<212> PRT
<213> Homo sapiens
<400> 10756
Val Asn Trp Cys Glu
1 5
<210> 10757
<211> 28
<212> DNA
<213> Homo sapiens
<400> 10757
ccagccaaga ggagtgaact ggtgtgag 28
<210> 10758
<211> 28
<212> DNA
<213> Homo sapiens
<400> 10758
ggtcggttct cctcacttga ccacactc 28
Claims (39)
- 세포에서 LDLR(Low-Density Lipoprotein Receptor) 유전자의 내인성 발현을 증가시키는 방법으로서, 상기 방법은 LDLR 유전자 또는 LDLR 유전자에 의해 코딩된 전사체를 변형시키는 단계를 포함하는 것인 방법.
- 청구항 1에 있어서, 상기 LDLR 유전자는 CRISPR 뉴클레아제, 메가뉴클레아제(meganuclease), TALEN(transcription activator-like effector nuclease), 또는 ZFN(zinc finger nuclease)에 의해 변형되거나, 상기 LDLR 유전자에 의해 코딩된 전사물은 siRNA(small interfering RNA), shRNA(short hairpin RNA) 또는 miRNA(microRNA) 분자에 의해 변형되는 것인 방법.
- 청구항 1 또는 2에 있어서, 상기 LDLR 유전자, 또는 상기 LDLR 유전자에 의해 코딩된 전사체의 의 3' 비번역 영역(UTR)이 변형되는 것인 방법.
- 청구항 3에 있어서, 상기 LDLR 유전자의 3'UTR이 상기 3'UTR 또는 그의 일부의 절제(excision)에 의해 변형되는 것인 방법.
- 청구항 1 내지 4 중 어느 한 항에 있어서, 상기 방법은
적어도 하나의 CRISPR 뉴클레아제, 또는 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 분자; 및
가이드 서열 부분을 포함하는 RNA 분자, 또는 상기 RNA 분자를 코딩하는 DNA 분자를 포함하는 조성물을 상기 세포에게 투여하는 단계를 포함하고,
상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체는 상기 LDLR 유전자의 대립유전자에서 이중가닥 절단을 생성하여, 상기 LDLR 유전자의 발현을 증가시키는 것인 방법. - 청구항 1 내지 5 중 어느 한 항에 있어서, 상기 조성물은 개체의 세포 또는 배양물 중 세포에 도입되는 것인 방법.
- 청구항 1 내지 6 중 어느 한 항에 있어서, 상기 세포가 간세포, 헤파토사이트(hepatocyte) 또는 줄기세포인 것인 방법.
- 청구항 5 내지 7 중 어느 한 항에 있어서, 상기 CRISPR 뉴클레아제 또는 상기 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 분자 및 상기 RNA 분자 또는 상기 RNA 분자를 코딩하는 DNA 분자가 실질적으로 동시에 또는 상이한 시간에 상기 세포에 도입되는 것인 방법.
- 청구항 1 내지 8 중 어느 한 항에 있어서, 상기 세포 중 LDLR 유전자의 miRNA 결합 부위 또는 AUR(AU Rich region)은 삽입 또는 결실 돌연변이에 노출되는 것인 방법.
- 청구항 5 내지 9 중 어느 한 항에 있어서, 상기 RNA 분자의 가이드 서열 부분은 정지 코돈의 하류 적어도 30개 뉴클레오티드 또는 폴리아데닐화 신호의 상류 적어도 30개 뉴클레오티드에 위치한 LDLR 3'UTR 내의 부위를 표적화하는 것인 방법.
- 청구항 5 내지 10 중 어느 한 항에 있어서, 상기 RNA 분자의 가이드 서열 부분이 LDLR 대립유전자 내의 miRNA 결합 부위를 표적화하는 것인 방법.
- 청구항 5 내지 11 중 어느 한 항에 있어서, 상기 RNA 분자의 가이드 서열 부분은 miR-85 또는 miR-148 결합 부위를 표적화하는 것인 방법.
- 청구항 1 내지 12 중 어느 한 항에 있어서, miR 시드 서열(seed sequence)이 상기 LDLR 유전자를 변형시킨 결과로 불활성화되는 것인 방법.
- 청구항 13에 있어서, 상기 miR 시드 서열은 UGGUGCUA 또는 CACUGUG인 것인 방법.
- 청구항 13에 있어서, 상기 miR 시드 서열이 miR-85 또는 miR-148 시드 서열인 것인 방법.
- 청구항 5 내지 15 중 어느 한 항에 있어서, 상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체는 상기 LDLR 유전자의 두 대립유전자 모두에서 이중가닥 절단을 생성하는 것인 방법.
- 청구항 5 내지 16 중 어느 한 항에 있어서, 상기 RNA 분자의 가이드 서열 부분은 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 포함하는 것인 방법.
- 청구항 5 내지 17 중 어느 한 항에 있어서, 상기 세포에 도입되는 조성물은 가이드 서열 부분을 포함하는 제2 RNA 분자, 또는 상기 제2 RNA 분자를 코딩하는 DNA 서열을 추가로 포함하는 것인 방법.
- 청구항 18에 있어서, 상기 제2 RNA 분자의 가이드 서열 부분은 정지 코돈의 하류 적어도 30개 뉴클레오티드 또는 폴리아데닐화 신호의 상류 적어도 30개 뉴클레오티드에 위치한 LDLR 3'UTR 내의 부위를 표적화하는 것인 방법.
- 청구항 18 또는 19에 있어서, 상기 제2 RNA 분자의 가이드 서열 부분은 제1 RNA 분자의 서열 이외의 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 포함하는 것인 방법.
- 청구항 18 내지 20 중 어느 한 항에 있어서, LDLR 3'UTR 또는 그의 일부가 CRISPR 뉴클레아제와 제1 RNA 분자에 의해 형성된 이중가닥 절단 및 CRISPR 뉴클레아제와 제2 RNA 분자에 의해 형성된 이중가닥 절단에 의해 절제되는 것인 방법.
- 청구항 21에 있어서, 내인성 LDLR 폴리아데닐화 신호가 온전하게 유지되는 것인 방법.
- 청구항 5 내지 22 중 어느 한 항에 있어서, 상기 제1 RNA 분자 또는 제2 RNA 분자의 가이드 서열 부분은 완전히 상보적인 LDLR 표적 서열 대비 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하는 것인 방법.
- 청구항 23에 있어서, 상기 가이드 서열 부분은 완전히 상보적인 LDLR 표적 서열에 비해 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 포함하는 것인 방법.
- 청구항 23 또는 24에 있어서, 상기 가이드 서열 부분은 상기 LDLR 유전자의 돌연변이 대립유전자에 대해 더 높은 상보성을 갖는 가이드 서열 부분에 비해 상기 CRISPR 뉴클레아제와 상기 제1 RNA 분자의 복합체에 더 높은 표적화 특이성을 제공하는 것인 방법.
- 청구항 1 내지 25 중 어느 한 항에 있어서, 세포에서 내인성 LDLR 유전자의 발현 증가가 상기 LDLR 유전자의 변형 전 세포에서의 LDLR 전사체 수준 또는 LDLR 단백질 수준 대비 LDLR 전사체 수준 또는 LDLR 단백질 수준의 10% 이상, 25% 이상, 50% 이상, 75% 이상, 100% 이상, 150% 이상, 200% 이상, 250% 이상, 300% 이상, 350% 이상, 400% 이상, 450% 이상, 500% 이상, 550% 이상, 또는 600% 이상 증가로 측정되는 것인 방법.
- 청구항 1 내지 26 중 어느 한 항에 있어서, 내인성 LDLR 유전자의 발현의 증가는 상기 LDLR 유전자의 변형 전 세포의 LDL-C 흡수 대비 LDL-C 흡수의 적어도 10%, 적어도 25%, 적어도 50%, 적어도 75%, 적어도 100%, 적어도 150%, 적어도 200%, 적어도 250%, 적어도 300%, 적어도 350%, 적어도 400%, 적어도 450%, 또는 적어도 500% 증가를 가져오는 것인 방법.
- 서열번호 1 내지 10736 중 어느 하나, 또는 완전히 상보적인 LDLR 표적 서열 대비 1, 2, 3, 4, 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 포함하는 RNA 분자, 또는 상기 RNA 분자를 코딩하는 DNA 분자를 포함하는 조성물.
- 청구항 28에 있어서, CRISPR 뉴클레아제, 또는 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 분자를 추가로 포함하는 것인 조성물.
- 청구항 28 또는 29에 있어서, tracrRNA 분자를 추가로 포함하는 것인 조성물.
- 청구항 28 내지 30 중 어느 한 항에 있어서, 가이드 서열 부분을 포함하는 제2 RNA 분자, 또는 상기 제2 RNA 분자를 코딩하는 DNA 분자를 추가로 포함하는 것인 조성물.
- 청구항 31에 있어서, 상기 제2 RNA의 가이드 서열 부분은 정지 코돈의 하류 적어도 30개 뉴클레오티드 또는 폴리아데닐화 신호의 상류 적어도 30개 뉴클레오티드에 위치한 LDLR 3'UTR 내의 부위를 표적화하는 것인 조성물.
- 청구항 31 또는 32에 있어서, 상기 제2 RNA 분자의 가이드 서열 부분은 상기 제1 RNA 분자의 서열 이외의 서열번호 1 내지 10736 중 어느 하나, 또는 완전히 상보적인 LDLR 표적 서열 대비 1, 2, 3, 4, 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 제1 RNA 분자의 서열 이외의 서열번호 1 내지 10736 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 포함하는 것인 조성물.
- 청구항 1 내지 27 중 어느 한 항의 방법에 의해 변형된 세포, 또는 청구항 28 내지 33 중 어느 한 항의 조성물에 의해 변형된 세포.
- 세포에서 LDLR 대립유전자를 불활성화하는데 사용하기 위한 청구항 28 내지 33 중 어느 한 항의 조성물을 포함하는 약제로서, 상기 약제는 청구항 28 내지 33 중 어느 한 항의 조성물을 상기 세포에 전달하는 것에 의해 투여되는 것인 약제.
- 청구항 28 내지 33 중 어느 한 항의 조성물 또는 청구항 34의 변형된 세포를 고콜레스테롤혈증을 경험하고 있거나, 경험할 위험이 있는 개체에게 전달하는 것을 포함하는, 고콜레스테롤혈증을 치료, 개선, 또는 예방하기 위한, 청구항 28 내지 33 중 어느 한 항의 조성물 또는 청구항 34의 변형된 세포의 용도.
- 고콜레스테롤혈증을 치료, 개선 또는 예방하는데 사용하기 위한, 청구항 28 내지 33 중 어느 한 항의 조성물 또는 청구항 34의 변형된 세포를 포함하는 약제로서, 상기 약제는 청구항 28 내지 33 중 어느 한 항의 조성물, 또는 청구항 34의 변형된 세포를 고콜레스테롤혈증을 경험하고 있거나, 경험할 위험이 있는 개체에게 전달하는 것에 의해 투여되는 것인 약제.
- 청구항 28 내지 33 중 어느 한 항의 조성물 및 상기 조성물을 세포에 전달하기 위한 설명서를 포함하는, 세포에서 LDLR 발현을 증가시키기 위한 키트.
- 청구항 28 내지 33 중 어느 한 항의 조성물 또는 청구항 34의 변형된 세포, 및 고콜레스테롤혈증을 경험하고 있거나 경험할 위험이 있는 개체에게 상기 조성물 또는 변형된 세포를 전달하기 위한 설명서를 포함하는, 개체에서 고콜레스테롤혈증을 치료 또는 예방하기 위한 키트.
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