KR20240010451A - C3 세이프 하버 부위에서의 넉인 전략 - Google Patents
C3 세이프 하버 부위에서의 넉인 전략 Download PDFInfo
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Abstract
본 개시는 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열에 17 내지 50개의 인접 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 그의 조성물, 방법 및 용도를 제공한다. 구체적으로, 본 개시는 세포에서 C3 (complement component 3) 유전자의 대립유전자를 변형시키는 방법으로서, 하나 이상의 뉴클레아제, 및 17 내지 50개의 뉴클레오티드를 갖는 가이드 서열을 포함하는 RNA 분자를 포함하는 조성물을 세포에 도입하는 단계를 포함하는 것인 방법을 제공한다.
Description
본 출원은 2021년 3월 11일에 출원된 미국 가출원 번호 63/159,602의 이익을 주장하고, 상기 출원의 내용은 참조에 의해 본원에 포함된다.
본 출원 전체에서, 괄호 안의 참조를 포함하여 다양한 간행물이 참조된다. 본 출원에서 언급된 모든 간행물의 개시 전체는 본 발명이 속하는 기술 및 본 발명과 함께 사용될 수 있는 기술의 특징에 대한 추가적인 설명을 제공하기 위해 본 출원에 참조에 의해 포함된다.
서열
목록에 대한 참조
본 출원은 본 출원의 일부로 2022년 3월 10일에 제출된 텍스트 파일에 포함된, MS-Windows와 운영 체제 호환성을 갖는 IBM-PC 머신 포맷으로 2022년 2월 28일에 생성되고 크기가 1,526 킬로바이트인 "220310_91702-A-PCT_Sequence_Listing_AWG.txt"로 명명된 파일에 존재하는 뉴클레오티드 서열을 참조에 의해 포함한다.
인간 게놈에는 삽입 및 결실, 반복 서열의 카피 수 차이, 및 단일 염기 다형성(SNP) 등 여러 종류의 DNA 변이가 있다. SNP는 게놈에서 단일 뉴클레오티드(아데닌(A), 티민(T), 시토신(C) 또는 구아닌(G))가 인간 대상자 간에, 또는 개체의 염색체쌍 간에 상이할 때 발생하는 DNA 서열 변이이다. 수년에 걸쳐, 다양한 유형의 DNA 변이가 특성(trait)이나 질병 원인을 정확히 찾아내는 연구에서 마커로서 또는 유전 질환의 잠재적 원인으로서 연구 커뮤니티의 초점이 되어 왔다.
DNA 변이는 또한 세포에서 특정 DNA 부위를 표적화하기 위해 활용될 수도 있다. 예를 들어, 대립유전자-특이적 보체 성분 3(C3) 세이프 하버(safe harbor) 부위는 유해한 중단을 일으키지 않으면서 그 부위에 서열을 도입하도록 표적화될 수 있다. 이러한 표적화 전략은 간 관련 장애를 치료하기 위해 도입된 서열의 C3 프로모터 매개 발현을 가능하게 하기 위해 활용될 수 있다.
발명의 요약
선택적으로 C3 유전자 발현을 넉아웃시키지 않고, C3 프로모터의 제어 하에 유전자 또는 그의 일부의 발현을 가능하게 하는 전략이 본원에 개시된다.
본 개시는 C3 유전자의 2개의 대립유전자를 구별/식별하기 위해 적어도 하나의 자연 발생(natrually occurring) 뉴클레오티드 차이 또는 다형성(예를 들어, 단일 뉴클레오티드 다형성(SNP))을 이용할 수 있다.
본 개시는 또한 C3 (Complement component 3) 유전자의 대립유전자를 세포에서 변형시키는 방법으로서, 상기 방법은
적어도 하나의 CRISPR 뉴클레아제 또는 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 서열; 및
17 내지 50개의 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자, 또는 이를 코딩하는 뉴클레오티드 서열을 포함하는 조성물을 상기 세포에게 투여하는 단계를 포함하고,
상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체가 상기 C3 유전자의 대립유전자의 이중가닥 절단(double strand break)을 생성하는(affect) 것인 방법을 제공한다.
일부 구체예에서, 상기 조성물은 또한 공여체 분자를 포함하고, 상기 공여체 분자로부터의 뉴클레오티드 서열이 이중가닥 절단 부위에 또는 그 부근에 삽입되거나 카피된다. 유사하게, 일부 구체예에서, 상기 조성물은 도입되는 뉴클레오티드 서열의 발현이 상기 C3 유전자의 프로모터에 의해 매개되도록 상기 이중가닥 절단 부위에 도입되는 뉴클레오티드 서열을 포함하는 공여체 분자를 더 포함한다.
본 발명의 구체예에 따르면, 서열번호 1 내지 7,046 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분(guide sequence portion)을 포함하는 제1 RNA 분자가 제공된다. 일부 구체예에서, 상기 조성물은 CRISPR 뉴클레아제를 추가로 포함한다. 일부 구체예에서, 상기 조성물은 공여체 분자를 추가로 포함한다.
본 발명의 구체예에 따르면, 본원에 기술된 방법 중 어느 하나에 의해 변형된 세포가 제공된다. 일부 구체예에서, 상기 세포는 줄기 세포이다. 일부 구체예에서, 상기 세포는 간 세포(liver cell)이다. 일부 구체예에서, 상기 세포는 헤파토사이트(hepatocyte)이다. 일부 구체예에서, 상기 세포는 iPS-유래 헤파토사이트이다.
일부 구체예에서, 본원에 기재된 조성물 중 어느 하나를 세포로 전달하는 것은 시험관내(in vitor), 생체외(ex vivo) 또는 생체내(in vivo)에서 수행된다. 일부 구체예에서, 상기 방법은 생체외에서 수행되고, 상기 세포는 개별 환자로부터 제공/외식된다. 일부 구체예에서, 상기 방법은 변형되거나 편집된 C3 대립유전자를 갖는, 결과적으로 수득된 세포를 개별 환자에게 도입하는 단계(예를 들어, 자가 이식)를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 간 관련 장애(liver-related disorder)를 치료하는 방법으로서, 상기 방법은 간 관련 장애를 개체의 세포에 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 전달하는 단계를 포함하는 것인 방법이 제공된다. 일부 구체예에서, 상기 조성물은 공여체 분자를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 세포에 전달하는 것을 포함하는, 세포에서 C3 대립유전자(allele)를 변형 또는 편집하기 위한, 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물의 용도가 제공된다. 일부 구체예에서, 상기 조성물은 공여체 분자를 추가로 포함한다.
본 발명의 구체예에 따르면, 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는, 세포에서 C3 대립유전자(allele)를 변형 또는 편집하는데 사용하기 위한 약제(medicament)로서, 상기 약제는 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 상기 세포에 전달하는 것에 의해 투여되는 것인 약제가 제공된다. 일부 구체예에서, 상기 약제는 공여체 분자를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 간 관련 장애를 갖거나 가질 위험이 있는 개체의 세포에 전달하는 것을 포함하는, 간 관련 장애를 치료, 개선, 또는 예방하기 위한, 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물의 용도가 제공된다. 일부 구체예에서, 상기 조성물은 공여체 분자를 추가로 포함한다. 일부 구체예에서, 상기 방법은 생체외에서 수행되고, 상기 세포는 개체로부터 제공/외식된다. 일부 구체예에서, 상기 방법은 변형되거나 편집된 C3 대립유전자를 갖는, 결과적으로 수득된 세포를 개체에 도입하는 단계(예를 들어 자가 이식)를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는, 간 관련 장애를 치료, 개선, 또는 예방하는데 사용하기 위한 약제로서, 상기 약제는 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 간 관련 장애를 갖거나 가질 위험이 있는 개체의 세포에 전달하는 것에 의해 투여되는 것인 약제가 제공된다. 일부 구체예에서, 상기 약제는 공여체 분자를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자, CRISPR 뉴클레아제, 및/또는 tracrRNA, 및 상기 RNA 분자, CRISPR 뉴클레아제, 및/또는 tracrRNA를 세포에 전달하기 위한 설명서를 포함하는, 세포에서 C3 대립유전자의 변형 또는 편집을 위한 키트가 제공된다. 일부 구체예에서, 상기 키트는 공여자 분자를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 서열번호 1-7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자, CRISPR 뉴클레아제, 및/또는 tracrRNA, 및 상기 RNA 분자, CRISPR 뉴클레아제, 및/또는 tracrRNA를 간 관련 장애를 갖거나 가질 위험이 있는 개체의 세포에 전달하기 위한 설명서를 포함하는, 개체에서 간 관련 장애의 치료를 위한 키트가 제공된다. 일부 구체예에서, 상기 키트는 공여자 분자를 추가로 포함한다.
다르게 정의되지 않는 한, 본 명세서에 사용된 모든 기술 및/또는 과학 용어는 본 발명이 속하는 기술분야의 통상의 기술자가 일반적으로 이해하는 것과 동일한 의미를 갖는다. 본 명세서에 기술된 것과 유사하거나 균등한 방법 및 재료가 본 발명의 구체예의 실시 또는 테스트에 사용될 수 있지만, 예시적인 방법 및/또는 재료가 하기에 기술된다. 상충되는 경우, 정의를 포함한 본 명세서가 우선할 것이다. 또한, 재료, 방법 및 실시예는 단지 설명하는 것이며, 반드시 한정하는 것으로 의도되지 않는다.
본원에서 앞서 및 다른 곳에 사용되는 바와 같이 용어 "하나("a" 및 "an")"는 열거된 구성요소 중 "하나 이상"을 지칭하는 것으로 이해되어야 한다. 구체적으로 달리 언급되지 않는 한, 단수의 사용은 복수를 포함한다는 것이 통상의 기술자에게 명백할 것이다. 따라서, 용어 "하나" 및 "적어도 하나"는 본 출원에서 호환 적으로 사용된다.
달리 표시되지 않는 한, 본 교시를 더 잘 이해하기 위해 및 교시의 범위를 한정하지 않는 방식으로, 양, 백분율 또는 비율을 표현하는 모든 숫자, 및 본 명세서 및 청구범위에서 사용되는 다른 수치는 모든 경우에 용어 "약"으로 수식되는 것으로 이해되어야 한다. 따라서, 반대로 표시되지 않는 한, 하기 명세서 및 첨부된 청구범위에 제시된 수치 파라미터는 얻고자 하는 원하는 특성에 따라 변할 수 있는 근사치이다. 적어도, 각각의 수치 파라미터는 적어도 보고된 유효 숫자의 수에 비추어 및 반올림 기법을 적용하여 해석되어야 한다.
본 논의에서 달리 언급되지 않는 한, 본 발명의 구체예의 특징 또는 특징들의 특징적인 조건 또는 관계를 수식하는 "실질적으로" 및 "약"과 같은 형용사는 조건 또는 특징이 의도된 적용에 대한 구체예의 작동에 허용 가능한 허용 오차(tolerance) 내에서 정의됨을 의미하는 것으로 이해된다. 달리 나타내지 않는 한, 명세서 및 청구범위에서 단어 "또는"은 배타적인 "또는"이 아닌 포괄적인 "또는"인 것으로 간주되며, 그것이 결합시키는 항목들 중 적어도 하나 또는 임의의 조합을 나타낸다.
본 출원의 설명 및 청구범위에서, 동사 "포함하다(comprise)", "함유하다(include)" 및 "갖다" 각각 및 이들의 활용어는 동사의 목적어 또는 목적어들이 반드시 동사의 주어 또는 주어들의 구성요소, 요소 또는 부분의 완전한 열거가 아니라는 것을 나타내는 데 사용된다. 본원에서 사용되는 다른 용어는 당업계에 잘 알려진 의미로 정의되는 것으로 의도된다.
용어 "상동성 기반 복구(homology-directed repair)" 또는 "HDR"은, 예를 들어 DNA에서 이중-가닥 및 단일-가닥 절단의 복구 동안, 세포 내에서 DNA 손상을 복구하기 위한 메커니즘을 지칭한다. HDR은 뉴클레오티드 서열 상동성을 필요로 하며 이중-가닥 또는 단일 절단이 일어난 서열(예를 들어, DNA 표적 서열)을 복구하기 위해 "핵산 주형"(핵산 주형 또는 공여체 주형은 본 명세서에서 호환적으로 사용됨)을 사용한다. 이는, 예를 들어 핵산 주형으로부터 DNA 표적 서열로 유전 정보의 전달을 초래한다. HDR은 핵산 주형 서열이 DNA 표적 서열과 상이하고 핵산 주형 폴리뉴클레오티드 또는 올리고뉴클레오티드의 일부 또는 전부가 DNA 표적 서열 내로 결합(incorporate)되는 경우, DNA 표적 서열의 변경(예를 들어, 삽입, 결실, 돌연변이)을 초래할 수 있다. 일부 구체예에서, 전체 핵산 주형 폴리뉴클레오티드, 핵산 주형 폴리뉴클레오티드의 일부, 또는 핵산 주형의 카피가 DNA 표적 서열의 부위에서 통합된다.
용어 "핵산 주형(nucleic acid template)" 및 "공여체(donor)"는 게놈 내로 삽입되거나 카피되는 뉴클레오티드 서열을 지칭한다. 핵산 주형은, 표적 핵산에서 부가될 것이거나 변화의 주형이 될 것이거나 표적 서열을 변형하기 위해 사용될 수 있는, 예를 들어 하나 이상의 뉴클레오티드의 뉴클레오티드 서열을 포함한다. 핵산 주형 서열은 임의의 길이, 예를 들어 2 내지 10,000개 뉴클레오티드 길이일 수 있다. 핵산 주형은 단일 가닥 핵산, 이중 가닥 핵산일 수 있다. 일부 구체예에서, 핵산 주형은, 예를 들어 표적 위치의 표적 핵산의 야생형 서열에 상응하는, 예를 들어 하나 이상의 뉴클레오티드의 뉴클레오티드 서열을 포함한다. 일부 구체예에서, 핵산 주형은, 예를 들어 표적 위치의, 표적 핵산의 야생형 서열에 상응하는, 예를 들어 하나 이상의 리보뉴클레오티드의, 뉴클레오티드 서열을 포함한다. 일부 구체예에서, 핵산 주형은 변형된 뉴클레오티드를 포함한다.
외인성 서열("공여체 서열", "공여체 주형" 또는 "공여체"로도 불림)의 삽입이 또한 수행될 수 있다. 예를 들어, 공여체 서열은 목적 위치에서 효율적인 HDR(homology-directed repair)을 가능하게 하기 위해 상동성인 2개 영역에 측접하는(flanking) 비-상동성 영역을 포함할 수 있다. 추가적으로, 공여체 서열은 세포 염색질 중 목적 영역과 상동성이 아닌 서열을 포함하는 벡터 분자를 포함할 수 있다. 공여체 분자는 세포 염색질과 상동성인 수개의 불연속 영역을 포함할 수 있다. 예를 들어, 일반적으로 목적 영역에 존재하지 않는 서열의 표적화된 삽입을 위해, 상기 서열은 공여체 핵산 분자에 존재하고, 목적 영역 내 서열과 상동성인 영역에 측접할 수 있다. 공여체 분자는 임의의 길이, 예를 들어, 수개의 염기, 예를 들어 10-20개 염기 내지 수 킬로베이스 범위의 길이일 수 있다.
공여체 폴리뉴클레오티드는 DNA 또는 RNA, 단일-가닥 및/또는 이중-가닥일 수 있고, 선형 또는 환형 형태로 세포 내에 도입될 수 있다. 예를 들어, 미국 특허 공개 제2010/0047805호; 제2011/0281361호; 제2011/0207221호; 및 제2019/0330620호를 참조한다. 선형 형태로 도입되는 경우, 공여체 서열의 말단은 통상의 기술자에게 알려진 방법에 의해 (예를 들어, 핵산말단 가수분해(exonucleolytic degradation)로부터) 보호될 수 있다. 예를 들어, 하나 이상의 디데옥시뉴클레오티드 잔기가 선형 분자의 3' 말단에 부가되고 및/또는 자가-상보성(self-complementary) 올리고뉴클레오티드가 일 말단 또는 양 말단에 라이게이션된다. 예를 들어, Chang and Wilson, Proc. Natl. Acad. Sci. USA (1987); Nehls et al., Science (1996)을 참조한다. 분해로부터 외인성 폴리뉴클레오티드를 보호하기 위한 추가적인 방법은 말단 아미노기(들)의 부가 및, 예를 들어 포스포로티오에이트, 포스포르아미데이트, 및 O-메틸 리보오스 또는 데옥시리보오스 잔기와 같은 변형된 뉴클레오티드간 연결(internucleotide linkage)의 사용을 포함하나 이에 한정되지 않는다.
공여체 서열은 또한 올리고뉴클레오티드일 수 있고 내인성(endogenous) 서열의 표적화된 변경에 사용될 수 있다. 올리고뉴클레오티드는 벡터 상에서 세포로 도입될 수 있거나, 세포 내에 전기천공될 수 있거나, 당업계에 알려진 기타 방법을 통해 도입될 수 있다. 공여체 폴리뉴클레오티드는 네이키드(naked) 핵산으로서, 리포좀 또는 폴록사머와 같은 작용제(agent)와 복합체화된 핵산으로서 도입될 수 있거나, 바이러스(예를 들어, 아데노바이러스, AAV, 헤르페스바이러스, 레트로바이러스, 렌티바이러스 및 인테그라제 결함 렌티바이러스(IDLV))에 의해 전달될 수 있다.
본원에서 사용된, 용어 "변형된 세포(modified cell)"는 표적 서열과의 혼성화, 즉 온타겟 혼성화의 결과로 RNA 분자와 CRISPR 뉴클레아제의 복합체에 의해 이중가닥 절단이 수행된 세포를 의미한다. 용어 "변형된 세포"는 이중가닥 절단 후, 외인성 서열의 도입을 포함한, 편집 또는 변형이 수행된 세포를 추가로 포함할 수 있다.
본 발명은 본원에 기술된 임의의 방법을 사용하여 수득된 변형된 세포를 제공한다. 일 구체예에서, 이들 변형된 세포 또는 세포들은 자손(progeny) 세포를 생성할 수 있다. 일 구체예에서, 이들 변형된 세포 또는 세포들은 생착(engraftment) 후에 자손 세포를 생성할 수 있다. 비-한정적인 예로서, 변형된 세포는 조혈 줄기 세포(HSC), 또는 동종 세포 이식 또는 자가 세포 이식에 적합한 임의의 세포일 수 있다. 비한정적인 예로서, 변형된 세포는 줄기세포, 간세포, 헤파토사이트 또는 iPS 유래 헤파토사이트일 수 있다.
본 발명은 또한 이들 변형된 세포 및 약학적으로 허용되는 담체를 포함하는 조성물을 제공한다. 또한, 상기 세포를 약학적으로 허용되는 담체와 혼합하는 것을 포함하는, 이를 제조하는 시험관내 또는 생체외 방법이 제공된다.
본원에서 사용된, 용어 "표적화 서열(targeting sequence)" 또는 "표적화 분자"는 특정 표적 서열에 혼성화할 수 있는 뉴클레오티드 서열을 포함하는 뉴클레오티드 서열 또는 분자를 의미하고, 예를 들어, 표적화 서열은 표적화 서열의 길이에 따라 표적화되는 서열에 적어도 부분적으로 상보적인 뉴클레오티드 서열을 갖는다. 표적화 서열 또는 표적화 분자는 단독으로 또는 다른 RNA 분자와 함께 CRISPR 뉴클레아제와 복합체를 형성할 수 있는 표적화 RNA 분자의 일부일 수 있으며, 상기 표적화 서열은 CRISPR 복합체의 표적화 부분(targeting portion)으로 작용한다. 표적화 서열을 갖는 분자가 CRISPR 분자와 동시에 존재하는 경우, 상기 RNA 분자는 단독으로 또는 추가적인 하나 이상의 RNA 분자(예: tracrRNA 분자)와 조합하여 CRISPR 뉴클레아제를 특정 표적 서열로 표적화할 수 있다. 비한정적인 예로서, CRISPR RNA 분자 또는 단일 가이드 RNA 분자의 가이드 서열 부분은 표적화 분자로 작용할 수 있다. 각 가능성은 별개의 구체예를 나타낸다. 표적화 서열은 원하는 서열을 표적화하도록 맞춤 설계될 수 있다.
본원에서 사용된, 용어 "표적(target)"은 표적화된 뉴클레오티드 서열을 갖는 핵산에 대한 표적화 서열 또는 표적화 분자의 우선적인 혼성화를 의미한다. 용어 "표적"은, 표적화된 뉴클레오티드 서열을 갖는 핵산의 우선적인 표적화가 존재하나, 온타겟 혼성화 외에, 의도하지 않은 오프타겟 혼성화가 또한 일어날 수 있도록, 가변 혼성화 효율(variable hybridization efficiency)을 포함하는 것으로 이해된다. RNA 분자가 서열을 표적화하는 경우, RNA 분자와 CRISPR 뉴클레아제 분자의 복합체는 뉴클레아제 활성을 위해 상기 서열을 표적화하는 것으로 이해된다.
RNA 분자의 "가이드 서열 부분(guide sequence portion)"은 특정 표적 DNA 서열에 혼성화할 수 있는 뉴클레오티드 서열을 지칭하고, 예를 들어 가이드 서열 부분은 가이드 서열 부분의 길이를 따라 표적화되는 DNA 서열에 부분적으로 또는 완전히 상보적인 뉴클레오티드 서열을 갖는다. 일부 구체예에서, 상기 가이드 서열 부분은 길이가 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 또는 50개 뉴클레오티드, 또는 길이가 대략 17 내지 50, 17 내지 49, 17 내지 48, 17 내지 47, 17 내지 46, 17 내지 45, 17 내지 44, 17 내지 43, 17 내지 42, 17 내지 41, 17 내지 40, 17 내지 39, 17 내지 38, 17 내지 37, 17 내지 36, 17 내지 35, 17 내지 34, 17 내지 33, 17 내지 31, 17 내지 30, 17 내지 29, 17 내지 28, 17 내지 27, 17 내지 26, 17 내지 25, 17 내지 24, 17 내지 22, 17 내지 21, 18 내지 25, 18 내지 24, 18 내지 23, 18 내지 22, 18 내지 21, 19 내지 25, 19 내지 24, 19 내지 23, 19 내지 22, 19 내지 21, 19 내지 20, 20 내지 22, 18 내지 20, 20 내지 21, 21 내지 22, 또는 17 내지 20개 뉴클레오티드이다. 바람직하게는, 가이드 서열 부분의 전체 길이는 가이드 서열 부분의 길이를 따라 표적화된 DNA 서열에 완전히 상보적이다. 가이드 서열 부분은 CRISPR 뉴클레아제와 복합체를 형성할 수 있는 RNA 분자의 일부일 수 있으며, 상기 가이드 서열 부분은 CRISPR 복합체의 DNA 표적화 부분의 역할을 한다. 가이드 서열 부분을 갖는 RNA 분자가 CRISPR 분자와 동시에, 단독으로 또는 추가의 하나 이상의 RNA 분자(예: tracrRNA 분자)와 조합하여 존재할 때, RNA 분자는 CRISPR 뉴클레아제를 특정 표적 DNA 서열에 표적화할 수 있다. 따라서, CRISPR 복합체는 가이드 서열 부분을 갖는 RNA 분자가 CRISPR 뉴클레아제에 직접 결합하거나, 가이드 서열 부분 및 추가적인 하나 이상의 RNA 분자를 갖는 RNA 분자가 CRISPR 뉴클레아제에 결합함으로써 형성될 수 있다. 각각의 가능성은 별개의 구체예를 나타낸다. 가이드 서열 부분은 원하는 서열을 표적화하도록 맞춤 설계될 수 있다. 따라서, "가이드 서열 부분"을 포함하는 분자는 표적화 분자의 한 유형이다. 일부 구체예에서, 가이드 서열 부분은 본원에 기재된 가이드 서열 부분, 예를 들어 서열번호 1-7,046 중 어느 하나에 기재된 가이드 서열과 동일하거나 1, 2, 3, 4 또는 5개 이하의 뉴클레오티드가 다른 서열을 포함한다. 각 가능성은 별개의 구체예를 나타낸다. 이러한 구체예 중 일부에서, 가이드 서열 부분은 서열번호 1-7,046 중 어느 하나에 기재된 서열과 동일한 서열을 포함한다. 본 출원 전체에 걸쳐, 용어 "가이드 분자", "RNA 가이드 분자", "가이드 RNA 분자", 및 "gRNA 분자"는 가이드 서열 부분을 포함하는 분자와 동의어이다.
본원에서 사용된 용어 "비차별적(non-discriminatory)"은 유전자의 두 대립유전자 모두에 공통적인 특정 DNA 서열을 표적으로 하는 RNA 분자의 가이드 서열 부분을 의미한다. 예를 들어, 비차별적 가이드 서열 부분은 세포에 존재하는 유전자의 대립유전자 둘 다를 표적으로 삼을 수 있다.
본 발명의 구체예에서, RNA 분자는 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함한다.
RNA 분자 및/또는 RNA 분자의 가이드 서열 부분은 변형된 뉴클레오티드를 포함할 수 있다. 뉴클레오티드 또는 폴리뉴클레오티드에 대한 예시적인 변형은 합성일 수 있으며 천연 아데닌, 시토신, 티민, 우라실 또는 구아닌 염기 이외의 염기를 포함하는 뉴클레오티드를 함유하는 폴리뉴클레오티드를 포함할 수 있다. 폴리뉴클레오티드에 대한 변형은 합성, 비천연 뉴클레오시드를 포함하는 폴리뉴클레오티드, 예를 들어, LNA(locked nucleic aicd)를 포함한다. 폴리뉴클레오티드에 대한 변형은 RNA의 안정성을 증가시키거나 감소시키기 위해 활용될 수 있다. 변형된 폴리뉴클레오티드의 예는 1-메틸 슈도-우리딘을 함유하는 mRNA이다. 변형된 폴리뉴클레오티드의 예 및 그의 용도에 대해, 각각 참조에 의해 본원에 포함된, US 특허 8,278,036, PCT 국제 공개 WO/2015/006747, 및 Weissman 및 Kariko(2015)를 참조한다.
본원에서 사용된, 서열번호에 기재된 "연속 뉴클레오티드(contiguous nucleotide)"는 임의의 개재(intervening) 뉴클레오티드 없이 서열번호에 기재된 순서의 뉴클레오티드의 서열의 뉴클레오티드를 의미한다.
본 발명의 구체예에서, 가이드 서열 부분은 길이가 25개 뉴클레오티드일 수 있고, 서열번호 1-7,046 중 어느 하나에 제시된 서열 중 20-22개의 연속 뉴클레오티드를 포함할 수 있다. 본 발명의 구체예에서, 상기 가이드 서열 부분은 길이가 22개 뉴클레오티드 미만일 수 있다. 예를 들어, 본 발명의 구체예에서, 상기 가이드 서열 부분은 길이가 17, 18, 19, 20 또는 21개 뉴클레오티드일 수 있다. 이러한 구체예에서, 상기 가이드 서열 부분은 서열번호 1-7,046 중 어느 하나에 제시된 17-22개의 연속 뉴클레오티드 서열에서 각각 17, 18, 19, 20 또는 21개의 뉴클레오티드로 구성될 수 있다. 예를 들어, 서열번호 7,047에 제시된 17개의 연속 뉴클레오티드의 서열에서 17개의 뉴클레오티드를 갖는 가이드 서열 부분은 하기 뉴클레오티드 서열 중 어느 하나로 구성될 수 있다(연속 서열에서 제외된 뉴클레오티드는 취소선(strike-through)으로 표시됨):
본 발명의 구체예에서, 가이드 서열 부분은 길이가 20개 초과의 뉴클레오티드일 수 있다. 예를 들어, 본 발명의 구체예에서, 가이드 서열 부분은 길이가 21, 22, 23, 24, 25, 26, 27, 28, 29 또는 30개 뉴클레오티드일 수 있다. 이러한 구체예에서, 가이드 서열 부분은 서열번호 1-7,046 중 어느 하나에 제시된 20개, 21개 또는 22개 연속 뉴클레오티드의 서열을 포함하는 17-50개의 뉴클레오티드 및 표적 서열의 3' 말단, 표적 서열의 5' 말단, 또는 둘 다에 인접한 뉴클레오티드 또는 뉴클레오티드 서열에 완전히 상보적인 추가 뉴클레오티드를 포함한다.
본 발명의 구체예에서, CRISPR 뉴클레아제와 가이드 서열 부분을 포함하는 RNA 분자는 표적 DNA 서열에 결합하여 표적 DNA 서열을 절단하는 CRISPR 복합체를 형성한다. CRISPR 뉴클레아제, 예를 들면, Cpf1은 추가 tracrRNA 분자 없이 CRISPR 뉴클레아제 및 RNA 분자를 포함하는 CRISPR 복합체를 형성할 수 있다. 대안적으로, CRISPR 뉴클레아제, 예를 들어 Cas9는 CRISPR 뉴클레아제, RNA 분자 및 tracrRNA 분자 간에 CRISPR 복합체를 형성할 수 있다. 특정 표적 DNA 서열에 혼성화할 수 있는 뉴클레오티드 서열을 포함하는 가이드 서열 부분, 및 CRISPR 뉴클레아제 결합에 참여하는 서열 부분, 예를 들어 tracrRNA 서열 부분은 동일한 RNA 분자 상에 위치할 수 있다. 대안적으로, 가이드 서열 부분은 하나의 RNA 분자에 위치할 수 있고 CRISPR 뉴클레아제 결합에 참여하는 서열 부분, 예를 들어 tracrRNA 부분은 별개의 RNA 분자에 위치할 수 있다. 가이드 서열 부분(예: DNA 표적화 RNA 서열) 및 적어도 하나의 CRISPR 단백질 결합 RNA 서열 부분(예: tracrRNA 서열 부분)을 포함하는 단일 RNA 분자는 CRISPR 뉴클레아제와 복합체를 형성하고 DNA-표적화 분자로 역할을 할 수 있다. 일부 구체예에서, 가이드 서열 부분을 포함하는 DNA-표적화 RNA 부분을 포함하는 제1 RNA 분자와 CRISPR 단백질-결합 RNA 서열을 포함하는 제2 RNA 분자는 염기쌍 형성에 의해 상호작용하여 CRISPR 뉴클레아제를 DNA 표적 부위로 표적화는 RNA 복합체를 형성하거나, 대안적으로 함께 융합되어 CRISPR 뉴클레아제와 복합체를 형성하고 CRISPR 뉴클레아제를 DNA 표적 부위로 표적화하는 RNA 분자를 형성한다.
본 발명의 구체예에서, 가이드 서열 부분을 포함하는 RNA 분자는 tracrRNA 분자의 서열을 추가로 포함할 수 있다. 이러한 구체예는 RNA 분자의 가이드 부분과 트랜스 활성화 crRNA(tracrRNA)의 합성 융합체(synthetic fusion)로 설계될 수 있다. (Jinek et al., 2012 참조). 이러한 구체예에서, RNA 분자는 단일 가이드 RNA(sgRNA) 분자이다. 본 발명의 구체예는 또한 별개의 tracrRNA 분자 및 가이드 서열 부분을 포함하는 별개의 RNA 분자를 활용하여 CRISPR 복합체를 형성할 수 있다. 이러한 구체예에서, tracrRNA 분자는 염기쌍 형성을 통해 RNA 분자와 혼성화할 수 있고, 본원에 기술된 본 발명의 특정 적용에 유리할 수 있다.
용어 "tracr 메이트 서열(tracre mate sequence)"은 염기쌍을 통해 tracrRNA에 혼성화하고 CRISPR 복합체의 형성을 촉진하도록 tracrRNA 분자에 충분히 상보적인 서열을 의미한다. (미국 특허 번호 8,906,616 참조). 본 발명의 구체예에서, RNA 분자는 tracr 메이트 서열을 갖는 부분을 추가로 포함할 수 있다.
본 개시의 목적상 "유전자"는 유전자 산물을 코딩하는 DNA 영역, 및 유전자 산물의 생산을 조절하는 조절 서열이 코딩 및/또는 전사된 서열에 인접한지 여부에 관계없이, 유전자 산물의 생산을 조절하는 모든 DNA 영역을 포함한다. 따라서, 유전자는 프로모터 서열, 종결자(terminator), 번역 조절 서열, 예를 들면, 리보솜 결합 부위 및 내부 리보솜 진입 부위(internal ribosome entry site), 인핸서, 사일런서(silencer), 인슐레이터(insulator), 경계 요소(boundary element), 복제 기원, 매트릭스 부착 부위(matrix attachment site) 및 유전자좌 조절 영역(locus control region)을 포함하나, 반드시 이에 국한되는 것은 아니다.
"진핵" 세포는 진균 세포(예: 효모), 식물 세포, 동물 세포, 포유동물 세포 및 인간 세포를 포함하나, 이에 한정되지 않는다.
본원에서 사용된, 용어 "뉴클레아제"는 핵산의 뉴클레오티드 서브유닛 사이의 포스포디에스테르 결합을 절단할 수 있는 효소를 지칭한다. 뉴클레아제는 천연 공급원으로부터 단리되거나 유래될 수 있다. 천연 공급원은 임의의 살아있는 유기체일 수 있다. 대안적으로, 뉴클레아제는 포스포디에스테르 결합 절단 활성을 유지하는 변형된 또는 합성 단백질일 수 있다. 유전자 변형은 뉴클레아제, 예를 들어 CRISPR 뉴클레아제를 사용하여 달성될 수 있다.
본 발명의 구체예에 따르면, C3 유전자의 대립유전자 또는 그 근처에 위치하는 SNP 위치(REF/SNP 서열)를 포함하는 표적 서열에 완전히 또는 부분적으로 상보적인 뉴클레오티드 서열을 포함하는 가이드 서열 부분(예를 들어 표적화 서열)을 포함하는 RNA 분자가 제공된다. 일부 구체예에서, RNA 분자의 가이드 서열 부분은 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 또는 26개 이상의 뉴클레오티드로 구성된다. 일부 구체예에서, 가이드 서열 부분은 CRISPR 뉴클레아제를 표적 서열에 표적화하고, C3 표적 부위의 500, 400, 300, 200, 100, 50, 25 또는 10개 뉴클레오티드 이내의 이중 가닥 절단 및 단일 가닥 절단으로부터 선택되는, 그와 복합체화된 CRISPR 뉴클레아제에 의한 절단 사건을 제공하도록 구성된다, 일부 구체예에서, RNA 분자는 crRNA 분자 또는 단일-가이드 RNA 분자와 같은 가이드 RNA 분자이다.
본원에서 사용된, 용어 "HSC"는 조혈 줄기 세포 및 조혈 줄기 전구 세포(hematopoietic stem progenitor cell)를 의미한다. 줄기 세포의 비한정적인 예는 골수 세포, 골수 전구 세포, 다능 전구 세포 및 계통 제한 전구 세포(lineage restricted progenitor cell)를 포함한다.
본원에서 사용된, "전구 세포(progenitor cell)"는 줄기 세포로부터 유래되고 유사분열 능력 및 다능성을 유지하는(예를 들어, 세포의 성숙한 계통(mature lineage)의 모든 유형이 아닌 하나 초과의 유형으로 분화하거나 발달할 수 있음) 계통 세포를 의미한다. 본원에서 사용된, "조혈" 또는 "혈액 생성"은 체내에서(예를 들면, 골수에서) 다양한 유형의 혈액 세포(예: 적혈구, 거핵구, 골수 세포(예: 단핵구, 대식세포 및 호중구) 및 림프구) 및 기타 형성된 요소의 형성 및 발생을 의미한다.
본원에서 사용된, 용어 "단일염기 다형성(SNP) 위치"는 종의 일원들 사이, 또는 개체의 쌍을 이루는 염색체들 사이에 단일염기 DNA 서열 변이가 발생하는 위치를 의미한다. 개체의 염색체 쌍에 SNP 위치가 존재하는 경우, 염색체 중 하나에 있는 SNP는 "이형접합성(heterozygous) SNP"이다. 용어 SNP 위치는 특정 변이가 발생하는 특정 핵산 위치를 의미하며 특정 핵산 위치에서 가장 빈번하게 발생하는 염기로부터의 변이를 포함하는 서열("SNP" 또는 대안적 "ALT"라고도 함) 및 특정 핵산 위치에서 가장 빈번하게 발생하는 염기를 포함하는 서열(참조(reference) 또는 "REF"로도 지칭됨)을 포함한다. 따라서, SNP 위치의 서열은 SNP(즉, 집단 내의 컨센서스 참조 서열(consensus reference sequence)에 대한 대안적인 서열 변이체) 또는 참조 서열 자체를 반영할 수 있다.
본 발명의 일부 구체예에 따르면, C3 (Complement component 3) 유전자의 대립유전자를 세포에서 변형시키는 방법으로서, 상기 방법은
적어도 하나의 CRISPR 뉴클레아제 또는 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 서열; 및
17 내지 50개의 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자, 또는 이를 코딩하는 뉴클레오티드 서열을 포함하는 조성물을 상기 세포에게 투여하는 단계를 포함하고,
상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체가 상기 C3 유전자의 대립유전자의 이중 가닥 절단을 생성하는(affect) 것인 방법이 제공된다.
일부 구체예에서, 상기 조성물은 또한 공여체 분자를 포함한다. 일부 구체예에서, 상기 공여체 분자로부터의 뉴클레오티드 서열이 이중가닥 절단 부위에 또는 그 부근에 삽입되거나 카피된다.
일부 구체예에서, 상기 조성물은 도입되는 뉴클레오티드 서열의 발현이 상기 C3 유전자의 프로모터에 의해 매개되도록 상기 이중가닥 절단 부위에 도입되는 뉴클레오티드 서열을 포함하는 공여체 분자를 추가로 포함한다.
일부 구체예에서, 상기 도입되는 서열은 ATP7B, A1AT, G6PC, SERPINA, LDLR, TTR, 오르니틴 트랜스카르바밀라아제, 아르기니노숙신산 합성효소, 아르기나아제, 아르기니노숙시나아제, 카르바모일 포스페이트 합성효소, N-아세틸글루타메이트 합성효소 유전자로부터의 서열이다.
일부 구체예에서, 상기 RNA 분자는 CRISPR 뉴클레아제를 C3 대립유전자의 SNP 위치로 표적화한다.
일부 구체예에서, 상기 SNP 위치는 rs17030, rs199713383 및 rs35473940 중 어느 하나이다.
일부 구체예에서, 제1 RNA 분자의 가이드 서열 부분은 C3 대립유전자의 SNP 위치를 표적으로 하는 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함한다.
일부 구체예에서, 상기 SNP 위치는 이형접합성 SNP를 포함한다.
일부 구체예에서, 상기 SNP 위치는 C3 대립유전자의 엑손 또는 인트론에 존재한다.
일부 구체예에서, 상기 RNA 분자는 C3 대립유전자 둘 모두를 표적화하는 비차별적 가이드 부분을 포함한다.
일부 구체예에서, 상기 RNA 분자는 C3의 인트론 1 또는 C3의 3' 비번역 영역(3' UTR)을 표적으로 하는 비차별적 가이드 부분 중 어느 하나를 표적으로 하는 비차별적 가이드 부분을 포함한다.
일부 구체예에서, 상기 RNA 분자는 19:6677732-6677881 및 19:6719404-6720515 중 어느 하나로부터 선택된 게놈 범위 내에 위치하는 서열을 표적으로 하는 비차별적 가이드 부분을 포함한다.
상기 RNA 분자의 가이드 서열 부분은 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함한다.
일부 구체예에서, 상기 RNA 분자의 가이드 서열 부분은 완전히 상보적인 C3 표적 서열 대비 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함한다.
일부 구체예에서, 상기 RNA 분자의 가이드 서열 부분은 완전히 상보적인 C3 표적 서열 대비 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함한다.
일부 구체예에서, 상기 가이드 서열 부분은 C3 유전자의 대립유전자에 대해 더 높은 상보성을 갖는 가이드 서열 부분에 비해 상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체에 더 높은 표적화 특이성을 제공한다.
본 발명의 구체예에 따르면, 본원에 제시된 구체예 중 어느 하나의 방법에 의해 수득된 변형된 세포가 제공된다.
일부 구체예에 따르면, 상기 세포는 줄기 세포, 간 세포, 헤파토사이트, 또는 iPS 유래 헤파토사이트이다.
본 발명의 구체예에 따르면, 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자가 제공된다.
본 발명의 구체예에 따르면, RNA 분자 및 적어도 하나의 CRISPR 뉴클레아제를 포함하는 조성물이 제공된다.
일부 구체예에서, 상기 RNA 분자는 서열번호 1 내지 7,046 중 어느 하나에 제시된 서열, 또는 완전히 상보적인 C3 표적 서열과 비교해 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1 내지 7,046 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함한다.
일부 구체예에서, 상기 조성물은 공여체 분자를 추가로 포함한다.
일부 구체예에서, 상기 공여체 분자는 ATP7B, A1AT, G6PC, SERPINA, LDLR, TTR, 오르니틴 트랜스카르바밀라아제, 아르기니노숙신산 합성효소, 아르기나아제, 아르기니노숙신산 합성효소, 카르바모일 포스페이트 합성효소, 및 N-아세틸글루타메이트 합성효소 유전자로부터의 서열을 포함한다.
본 발명의 구체예에 따르면, 세포에서 C3 대립유전자를 변형 또는 편집하는 방법으로서, 상기 방법은 본원에 제시된 구체예 중 어느 하나의 조성물을 상기 세포에 전달하는 단계를 포함하는 것인 방법이 제공된다.
본 발명의 구체예에 따르면, 간 관련 장애를 치료하는 방법으로서, 상기 방법은 간 관련 장애를 갖는 개체의 세포에 본원에서 제시된 구체예 중 어느 하나의 조성물을 전달하거나, 또는 변형된 세포를 상기 개체에 전달하는 것을 포함하는 것인 방법이 제공된다.
본 발명의 구체예에 따르면, 본원에 제시된 구체예 중 어느 하나의 조성물을 세포에 전달하는 것을 포함하는, 세포에서 C3 대립유전자를 변형 또는 편집하기 위한 본원에 제시된 조성물 중 어느 하나의 용도가 제공된다.
본 발명의 구체예에 따르면, 세포에서 C3 대립유전자를 변형 또는 편집하는데 사용하기 위해 본원에 제시된 구체예 중 어느 하나의 조성물을 포함하는 약제로서, 상기 약제는 본원에 제시된 구체예 중 어느 하나의 조성물을 상기 세포에 전달하는 것에 의해 투여되는 것인 약제가 제공된다.
본 발명의 구체예에 따르면, 본원에 제시된 구체예 중 어느 하나의 조성물을 간 관련 장애를 갖거나 가질 위험을 갖는 개체의 세포에 전달하거나, 본원에 제시된 방법 중 어느 하나에 의해 변형된 세포를 상기 개체에게 전달하는 것을 포함하는, 간 관련 장애를 치료, 개선, 또는 예방하기 위한, 본원에 제시된 구체예 중 어느 하나의 조성물 또는 변형된 세포의 용도가 제공된다.
본 발명의 구체예에 따르면, 간 관련 장애를 치료, 개선, 또는 예방하는데 사용하기 위한, 본원에 제시된 구체예 중 어느 하나의 조성물을 포함하는 약제로서, 상기 약제는 간 관련 장애를 갖거나 가질 위험이 있는 개체의 세포에 본원에 제시된 구체예 중 어느 하나의 조성물을 전달하는 것에 의해 투여되는 것인 약제가 제공된다.
본 발명의 구체예에 따르면, 본원에 제시된 구체예 중 어느 하나의 RNA 분자, CRISPR 뉴클레아제 및/또는 tracrRNA 분자, 및 상기 RNA 분자; CRISPR 뉴클레아제 및/또는 tracrRNA를 세포에 전달하기 위한 설명서를 포함하는, 세포에서 C3 대립유전자를 변형 또는 편집하기 위한 키트가 제공된다. 일부 구체예에서, 상기 키트는 공여체 분자, 및 공여체 분자를 세포에 전달하기 위한 설명서를 추가로 포함한다.
본 발명의 구체예에 따르면, 본원에 제시된 구체예 중 어느 하나의 RNA 분자, CRISPR 뉴클레아제 및/또는 tracrRNA 분자, 및 상기 RNA 분자; CRISPR 뉴클레아제 및/또는 tracrRNA를 간 관련 장애를 갖거나 또는 가질 위험이 있는 개체의 세포에 전달하기 위한 설명서를 포함하는, 개체에서 간 관련 장애를 치료하기 위한 키트가 제공된다. 일부 구체예에서, 상기 키트는 공여체 분자, 및 상기 공여체 분자를 세포에 전달하기 위한 설명서를 추가로 포함한다.
본 발명의 구체예에 따르면, 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자를 포함하는 유전자 편집 조성물이 제공된다. 일부 구체예에서, 상기 RNA 분자는 CRISPR 뉴클레아제에 결합하는 서열을 갖는 부분을 추가로 포함한다. 일부 구체예에서, CRISPR 뉴클레아제에 결합하는 서열은 tracrRNA 서열이다.
일부 구체예에서, 상기 RNA 분자는 tracr 메이트 서열을 갖는 부분을 추가로 포함한다.
일부 구체예에서, 상기 RNA 분자는 하나 이상의 링커 부분을 추가로 포함할 수 있다.
본 발명의 구체예에 따르면, RNA 분자는 최대 1000, 900, 800, 700, 600, 500, 450, 400, 350, 300, 290, 280, 270, 260, 250, 240, 230, 220, 210, 200, 190, 180, 170, 160, 150, 140, 130, 120, 110 또는 100개의 뉴클레오티드 길이일 수 있다. 각 가능성은 별개의 구체예를 나타낸다. 본 발명의 구체예에서, RNA 분자는 길이가 17개 내지 최대 300개 뉴클레오티드, 100개 내지 최대 300개 뉴클레오티드 길이, 150개 내지 300개 뉴클레오티드 길이, 100개 내지 500개 뉴클레오티드 길이, 100개 내지 400개 뉴클레오티드일 수 있다. 길이, 200개 내지 300개 뉴클레오티드 길이, 100개 내지 200개 뉴클레오티드 길이, 또는 150개 내지 250개 뉴클레오티드 길이일 수 있다. 각 가능성은 별개의 구체예를 나타낸다.
본 발명의 일부 구체예에 따르면, 상기 조성물은 tracrRNA 분자를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 세포에서 C3 대립유전자를 변형 또는 편집하는 방법으로서, 상기 방법은 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17개 내지 50개 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 상기 세포에서 전달하는 단계를 포함하는 것인 방법이 제공된다.. 일부 구체예에서, 상기 조성물은 공여체 분자를 추가로 포함한다.
본 발명의 일부 구체예에 따르면, 장애를 치료하는 방법으로서, 상기 방법은 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17개 내지 50개 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 상기 장애를 갖는 개체의 세포에 전달하는 단계를 포함하는 것인 방법이 제공된다. 일부 구체예에서, 상기 조성물은 공여체 분자를 추가로 포함한다. 일부 구체예에서, 상기 장애는 간 관련 장애이다. 일부 구체예에서, 상기 장애는 리소좀 축적 장애(lysosomal storage disorder)이다.
본 발명의 일부 구체예에 따르면, 개체의 간 세포에서 DNA 표적 부위를 변형시키는 방법으로서, 상기 DNA 표적 부위의 변형은 상기 간 세포가 변형에 의해 코딩된 원하는 단백질을 분비하도록 유도하고, 상기 방법은 상기 개체의 세포에 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17개 내지 50개 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제를 포함하는 조성물을 전달하는 단계를 포함하는 것인 방법이 제공된다. 일부 구체예에서, 조성물은 공여체 분자를 추가로 포함한다.
본 발명의 구체예에 따르면, 적어도 하나의 CRISPR 뉴클레아제 및 RNA 분자 또는 RNA 분자들은 실질적으로 동시에 또는 서로 다른 시간에 개체 및/또는 세포에 전달된다.
일부 구체예에서, tracrRNA 분자는 CRISPR 뉴클레아제 및 RNA 분자 또는 RNA 분자들과 실질적으로 동시에 또는 서로 다른 시간에 개체 및/또는 세포에 전달된다.
본 발명의 구체예에 따르면, 상기 RNA 분자는 엑손의 SNP, 인트론의 SNP, C3 유전자의 첫 번째 코딩 엑손 다음에 오는 첫 번째 인트론의 SNP, 인트론의 두 대립유전자에 공통적인 서열, C3 유전자의 첫 번째 암호화 엑손 다음에 오는 첫 번째 인트론 중 두 대립유전자에 공통된 서열, 프로모터 영역, 개시 코돈, 정지 코돈 또는 비번역 영역(UTR)의 SNP, 또는 2개의 C3 대립유전자 모두에 존재하는 서열을 표적으로 한다.
본 발명의 구체예에 따르면, 상기 RNA 분자는 C3 대립유전자의 엑손과 인트론 사이의 대안적 스플라이싱 신호 서열을 표적으로 한다.
본 발명의 구체예에 따르면, 상기 RNA 분자는 비차별적이며, 2개의 C3 대립유전자 모두에 존재하는 서열을 표적으로 삼는다. 일부 구체예에서, 서열은 C3 대립유전자 모두에 존재한다. 일부 구체예에서, 상기 서열은 C3 유전자의 인트론에 존재한다. 일부 구체예에서, 상기 인트론은 C3 유전자의 첫 번째 코딩 엑손 다음에 오는 첫 번째 인트론이다.
본 개시의 조성물 및 방법은 유전 장애와 같은 장애의 치료, 예방, 개선하거나 또는 진행을 늦추기 위해 활용될 수 있다. 예를 들어, 이러한 장애의 비제한적인 예는 간 관련 장애 또는 리소좀 축적 장애이다.
C3 대립유전자를 변형 또는 편집하기 위한 전술된 전략 중 임의의 하나 또는 이들의 조합이 본 발명의 맥락에서 사용될 수 있다.
일부 구체예에 따르면, 본 개시는 RNA-가이드 DNA 뉴클레아제. 예를 들면, CRISPR 뉴클레아제에 결합하거나 그와 회합하고 및/또는 그를 목적 유전자의 대립유전자 간에 서로 다른 적어도 하나의 뉴클레오티드(예를 들어, SNP)를 포함하는 표적 서열(예를 들어, 다른 C3 대립유전자에는 존재하지 않는 하나의 C3 대립유전자의 서열)로 지시하는 RNA 서열('RNA 분자'로도 지칭됨)을 제공한다.
일부 구체예에서, 상기 방법은 목적 유전자의 적어도 하나의 대립유전자를 비차별적 RNA 분자, 예를 들어 유전자의 대립유전자 둘 다를 표적화할 수 있는 가이드 서열 부분을 포함하는 RNA 분자 및 CRISPR 뉴클레아제, 예를 들면, Cas9 단백질과 접촉시키는 단계를 포함하고, 상기 비차별적 RNA 분자 및 상기 CRISPR 뉴클레아제는 목적 유전자의 적어도 하나의 대립유전자의 뉴클레오티드 서열과 회합하여 적어도 하나의 대립유전자를 변형시키거나 또는 편집한다. 특히, 비차별적 RNA 분자가 세포에 도입되면 이중 대립유전자 절단(biallelic cleavage)이 발생할 수 있지만, 절단 부위에 뉴클레오티드 서열의 삽입은 두 대립유전자 모두가 아닌 단일 대립유전자에서만 발생할 수 있다. 따라서, C3 유전자의 인트론을 표적으로 하는 비차별적 RNA 분자로 이중 대립유전자 절단을 유도하면 하나의 대립유전자로부터 내인성 C3 유전자의 발현이 보존되고 뉴클레오티드 서열, 예를 들어 공여체 분자로부터의 뉴클레오티드 서열이 나머지 대립유전자에 도입될 수 있다. C3 대립유전자에 뉴클레오티드 서열을 도입하면 C3 대립유전자에서 C3 코딩된 유전자 산물의 발현이 중단되거나 또는 중단되지 않을 수 있다.
일부 구체예에서, 상기 방법은 목적 유전자의 대립유전자를 대립유전자 특이적 RNA 분자 및 CRISPR 뉴클레아제, 예를 들면, Cas9 단백질과 접촉시키는 단계를 포함하고, 상기 대립유전자 특이적 RNA 분자 및 CRISPR 뉴클레아제는 상기 목적 유전자의 다른 대립유전자의 뉴클레오티드 서열과 적어도 하나의 뉴클레오티드가 다른 목적 유전자의 대립유전자의 뉴클레오티드 서열과 회합하여, 표적화된 대립유전자를 변형시키거나 편집한다.
일부 구체예에서, 상기 대립유전자 특이적 또는 비차별적 RNA 분자 및 CRISPR 뉴클레아제가 목적 유전자를 코딩하는 세포에 도입된다. 일부 구체예에서, 상기 목적 유전자를 코딩하는 세포는 포유동물 개체에 있다.
일부 구체예에서, 상기 RNA 분자는 집단에서 매우 우세하고 치료 대상 개별 개체의 적어도 하나의 C3 대립유전자에 존재하는 SNP를 표적으로 한다.
일부 구체예에서, 상기 SNP는 목적 유전자의 엑손 내에 있다. 이러한 구체예에서, RNA 분자의 가이드 서열 부분은 목적 유전자의 엑손 서열과 회합하도록 설계된다.
일부 구체예에서, SNP는 목적 유전자의 인트론 또는 엑손 내에 존재한다. 일부 구체예에서, SNP는 인트론과 엑손 사이의 스플라이스 부위(splice site)에 매우 근접해 있다. 일부 구체예에서, 스플라이스 부위에 대한 근접성은 스플라이스 부위의 상류 또는 하류 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 또는 20개 뉴클레오티드이다. 각각의 가능성은 본 발명의 별개의 구체예를 나타낸다. 이러한 구체예에서, RNA 분자의 가이드 서열 부분은 스플라이스 부위를 포함하는 목적 유전자의 서열과 회합하도록 설계될 수 있다.
일부 구체예에서, 개시된 발명의 방법은 장애 또는 질병을 가진 개체를 치료하기 위해 이용된다. 이러한 구체예에서, 상기 방법은 질병 표현형의 개선, 호전 또는 예방을 가져온다. 일부 구체예에서, 상기 질환 또는 장애는 간 관련 장애이다. 일부 구체예에서, 상기 질환 또는 장애는 리소좀 축적 장애이다.
본원에 기술된 조성물의 구체예는 적어도 하나의 CRISPR 뉴클레아제, 가이드 서열 부분을 포함하는 RNA 분자(들), 및 가이드 서열 부분을 포함하는 RNA 분자와 별개일 수 있거나, 또는 그에 부착될 수 있는 tracrRNA 분자를 포함하고, 이들은 개체 또는 세포에서 동시에 효과적이다. 상기 적어도 하나의 CRISPR 뉴클레아제, 가이드 서열 부분을 포함하는 RNA 분자(들) 및 tracrRNA는 실질적으로 동시에 전달될 수 있거나, 상이한 시간에 전달될 수 있으나, 동시에 효과를 가질 수 있다. 예를 들어, 이는 가이드 서열 부분을 포함하는 RNA 분자 및/또는 tracrRNA가 개체 또는 세포에 실질적으로 존재하기 전에, 개체 또는 세포에 CRISPR 뉴클레아제를 전달하는 것을 포함한다.
일부 구체예에서, 상기 세포는 줄기 세포이다. 일부 구체예에서, 상기 세포는 간 세포이다. 일부 구체예에서, 상기 세포는 헤파토사이트이다. 일부 구체예에서, 상기 세포는 iPS 유래 헤파토사이트이다.
간 관련 장애를 치료하기 위한 유전적 C3 세이프
하버
(Safe Harbor) 넉인
일부 구체예에서, 본 발명의 방법은 C3 세이프 하버 부위에서 서열을 넉인(knock-in)하는 데 사용될 수 있고, 넉인 서열의 C3 매개 발현은 장애 또는 질병의 치료에 관련되거나 연관된다.
비한정적 예로서, 넉인 서열의 발현은 간 관련 장애의 치료에 관련되거나 연관될 수 있다. 예를 들어, 넉인 서열은 ATP7B, A1AT, G6PC, SERPINA, LDLR, TTR, 오르니틴 트랜스카르바밀라아제, 아르기니노숙신산 합성효소, 아르기나아제, 아르기니노숙시나아제, 카르바모일 포스페이트 합성효소, 또는 N-아세틸글루타메이트 합성효소 서열, 또는 이의 일부일 수 있다.
또 다른 예에서, 간 세포의 C3 DNA 표적 부위는 간 세포가 변형에 의해 코딩된 단백질 산물을 발현하고 분비하도록 변형된다. 이러한 변형된 간 세포는 예를 들어 리소좀 축적 질환 또는 기타 장애를 치료하는 데 활용될 수 있다. 따라서, 이러한 변형된 세포는 전통적인 효소 대체 요법의 대안으로 작용한다. 비한정적 예로서, 간 세포는 알파 갈락토시다아제 A, 응고 인자 IX, 응고 인자 VII, 리소좀 알파 글루코시다아제, 피브리노겐, 페닐알라닌 4 히드록실라아제, 알칼리 포스파타아제, 글루코실세라미다아제, 베타 갈락토시다아제, 포르포빌리노겐 데아미나아제, 아릴술파타아제 B, 베타 글루쿠로니다아제, 알파 N 아세틸글루코사미니다아제, 리소좀 알파(Lysosomal Alpha), 알파 L-이두로니다아제, 만노시다아제, 포스파티딜콜린 스테롤 아실트랜스퍼라아제, N-술포글루코사민 술포히드롤라아제, 응고 인자 X, N-아세틸갈락토사민-6-술파타아제, 스핑고미엘린 포스포디에스테라아제, A1AT, 이두로네이트-2-술파타아제, 리소좀 알파 글루코시다아제, CDKL5(Cylcin Dependent Kinase Like 5), 프로-LRP1(Prolow Density Liporotein Receptor Related Protein 1), 페닐알라닌 암모니아 리아제, 단백질 글루타민 감마 글루타밀트랜스퍼라아제 K, 또는 리소좀 보호 단백질(Lysosome Protective Protein) 또는 이들의 일부를 발현하도록 변형될 수 있다.
C3 편집 전략은, 선택적으로 편집된 C3 대립유전자를 넉아웃시키지 않으면서, C3 프로모터의 제어 하에 원하는 서열의 발현을 가능하게 하는 전략을 포함한다. 이는 하기 전략에 의해 달성될 수 있다: (1) C3 대립유전자의 첫 번째 인트론, 또는 C3 대립유전자의 첫 번째 코딩 엑손 다음에 오는 첫 번째 인트론의 넉인(knock-in); (2) C3 대립유전자의 첫 번째 인트론, 또는 C3 대립유전자의 첫 번째 코딩 엑손 다음에 오는 첫 번째 인트론의 대립유전자 특이적 넉인; (3) C3 대립유전자의 정지 코돈 교체에 의한 넉인; 또는 (4) C3 대립유전자의 정지 코돈을 대립유전자 특이적 방식으로 교체하는 것에 의한 넉인.
CRISPR
뉴클레아제 및 PAM 인식
일부 구체예에서, 서열 특이적 뉴클레아제는 CRISPR 뉴클레아제 또는 그의 기능적 변이체(functional variant)로부터 선택된다. 일부 구체예에서, 서열 특이적 뉴클레아제는 RNA 가이드 DNA 뉴클레아제(RNA-guided DNA nuclease)이다. 이러한 구체예에서, RNA 가이드 DNA 뉴클레아제(예를 들어, Cpf1)를 가이드하는 RNA 서열은 RNA 가이드 DNA 뉴클레아제에 결합하고 및/또는 이를 C3 유전자의 대립유전자 간에 다른 적어도 하나의 뉴클레오티드를 포함하는 표적 서열(예를 들어, SNP)로 안내한다. 일부 구체예에서, CRISPR 복합체는 tracrRNA를 추가로 포함하지 않다. RNA 가이드 DNA 뉴클레아제가 CRISPR 단백질인 것인 비한정적 예에서, C3 대립유전자 간에 다른 적어도 하나의 뉴클레오티드는 RNA 분자가 혼성화되도록 설계된 영역 내의 결합하는 영역 내의 PAM 부위 내에 및/또는 PAM 부위에 근접할 수 있다. 통상의 기술자는 당업계에 일반적으로 공지된 방법에 의해 RNA 분자가 게놈 내의 선택된 표적에 결합하도록 조작될 수 있다는 것을 인식할 것이다.
본원에서 사용된, 용어 "PAM"은 표적화된 DNA 서열에 근접하게 위치하고 CRISPR 뉴클레아제에 의해 인식되는 표적 DNA의 뉴클레오티드 서열을 지칭한다. PAM 서열은 뉴클레아제 실체(identity)에 따라 다를 수 있다. 또한, 거의 모든 PAM을 표적화할 수 있는 CRISPR 뉴클레아제가 있다. 본 발명의 일부 구체예에서, CRISPR 시스템은 가이드 서열 부분과 표적 인식을 위한 추가적 요건인 프로토스페이서 인접 모티프(PAM) 옆에 있는 DNA 부위인, 표적 DNA 부위 상의 프로토스페이서 사이의 왓슨-크릭(Watson-Crick) 염기쌍 결합을 통해 CRISPR 뉴클레아제를 표적 DNA 부위로 지시하기 위해 가이드 서열 부분을 갖는 하나 이상의 RNA 분자를 이용한다. 그 후, CRISPR 뉴클레아제는 표적 DNA 부위의 절단을 매개하여 프로토스페이서 내에서 이중가닥 절단을 생성한다. 비한정적 예에서, 타입 II CRISPR 시스템은 CRISPR 뉴클레아제, 예를 들면, Cas9을 crRNA의 가이드 서열 부분과 프로토스페이서 인접 모티프(PAM) 옆에 있는 표적 DNA의 프로토스페이서 사이의 Watson-Crick 염기쌍 결합을 통해 표적 DNA로 지시하는 성숙한 crRNA:tracrRNA 복합체를 이용한다. 통상의 기술자는 본 발명의 조작된 RNA 분자 각각이 프로토스페이서 인접 모티프(PAM) 옆의 목적 표적 게놈 DNA 서열, 예를 들어 이용되는 CRISPR 뉴클레아제의 타입에 적합한 서열과 일치하는 PAM과 회합하도록 추가로 설계된다는 것을 이해할 것이다. 이용되는 CRISPR 뉴클레아제의 타입에 적합한 서열과 일치하는 PAM의 비한정적 예는 스트렙토코커스 피오게네스 Cas9 WT(SpCAS9)에 대한, "N"은 임의의 핵염기(nucleobse)인 것인 NGG 또는 NAG; 스태필로코커스 아우레우스(SaCas9)에 대한 NNGRRT; 제주니(Jejuni) Cas9 WT에 대한 NNNVRYM; SpCas9-VQR 변이체에 대한 NGAN 또는 NGNG; SpCas9-VRER 변이체에 대한 NGCG; SpCas9-EQR 변이체에 대한 NGAG; SpCas9-NRRH 변이체에 대한, N은 임의의 핵염기이고, R은 A 또는 G이며, H는 A, C 또는 T인 것인 NRRH; SpCas9-NRTH 변이체에 대한, N은 임의의 핵염기이고, R은 A 또는 G이고 H는 A, C 또는 T인 것인 NRTH; SpCas9-NRCH 변이체에 대한, N은 임의의 핵염기이고, R은 A 또는 G이고 H는 A, C 또는 T인 것인 NRCH; SpCas9의 SpG 변이체에 대한, N은 임의의 핵염기인 것인 NG; SpCas9의 NG 변이체에 대한, N은 임의의 핵염기인 것인 NG, 또는 NA; SpCas9의 SpRY 변이체에 대한, N은 임의의 핵염기이고, R은 A 또는 G이고 Y는 C 또는 T인 것인 NR, NRN 또는 NYN; 스트렙토코커스 카니스 Cas9 변이체(ScCas9)에 대한, N은 임의의 핵염기인 것인 NNG; 스태필로코커스 아우레우스의 SaKKH-Cas9 변이체(SaCas9)에 대한, N은 임의의 핵염기이고, R은 A 또는 G인 것인 NNNRRT; 나이세리아 메닌기티디스 (NmCas9)에 대한, N은 임의의 핵염기인 것인 NNNNGATT; 알리시클로바실러스 액시디필루스 Cas12b(AacCas12b)에 대한, N은 임의의 핵염기인 것인 TTN; 또는 Cpfl에 대한, V는 A, C 또는 G인 것인 TTTV이다. 본 발명의 RNA 분자는 각각 하나 이상의 상이한 CRISPR 뉴클레아제와 함께 복합체를 형성하도록 설계되고, 이용된 CRISPR 뉴클레아제에 대해 각각 하나 이상의 상이한 PAM 서열을 이용하여 목적 폴리뉴클레오티드 서열을 표적화하도록 설계된다.
일부 구체예에서, RNA 가이드 DNA 뉴클레아제, 예를 들면, CRISPR 뉴클레아제는 세포의 게놈의 원하는 위치에서 이중 가닥 또는 단일 가닥 DNA 절단을 유발하는 데 사용될 수 있다. 가장 일반적으로 사용되는 RNA 가이드 DNA 뉴클레아제는 CRISPR 시스템에서 유래되나, 기타 RNA 가이드 DNA 뉴클레아제도 본원에 기재된 게놈 편집 조성물 및 방법에 사용하기 위해 고려된다. 예를 들어, 본원에 참조에 의해 포함된, 미국 특허공개번호 2015/0211023을 참조한다.
본 발명의 실시에 사용될 수 있는 CRISPR 시스템은 매우 다양하다. CRISPR 시스템은 타입 I, 타입 II 또는 타입 III 시스템일 수 있다. 적합한 CRISPR 단백질의 비한정적 예는 Cas3, Cas4, Cas5, Cas5e(또는 CasD), Cas6, Cas6e, Cas6f, Cas7, Cas8al, Cas8a2, Cas8b, Cas8c, Cas9, Cas10, Cas10d, CasF, CasG, CasH, Csyl, Csy2, Csy3, Csel(또는 CasA), Cse2(또는 CasB), Cse3(또는 CasE), Cse4(또는 CasC), Cscl, Csc2, Csa5, Csn2, Csm2, Csm3, Csm4, Csm5, Csm6, Cmrl, Cmr3, Cmr4, Cmr5, Cmr6, Csbl, Csb2, Csb3, Csxl7, Csxl4, Csxl0, Csxl6, CsaX, Csx3, Cszl, Csxl5, Csfl, Csf2, Csf3, Csf4 및 Cul966을 포함한다.
일부 구체예에서, RNA 가이드 DNA 뉴클레아제는 타입 II CRISPR 시스템(예: Cas9)에서 유래된 CRISPR 뉴클레아제이다. CRISPR 뉴클레아제는 스트렙토코커스 피오게네스(Streptococcus pyogenes), 스트렙토코커스 써모필루스(Streptococcus thermophilus), 스트렙토코커스 종(Streptococcus sp .), 스태필로코커스 아우레우스(Staphylococcus aureus), 나이세리아 메닌기티디스(Neisseria meningitidis), 트레포네마 덴티콜라(Treponema denticola), 노카르디옵시스 다손빌레이(Nocardiopsis dassonvillei), 스트렙토마이세스 프리스티나에스피랄리스(Streptomyces pristinaespiralis), 스트렙토마이세스 비리도크로모게네스(Streptomyces viridochromogenes), 스트렙토마이세스 비리도크로모게네스, 스트렙토스포란기움 로세움(Streptosporangium roseum), 스트렙토스포란기움 로세움, 알리시클로바실러스 액시도칼다리우스(Alicyclobacillus acidocaldarius), 바실러스 슈도마이코이데스(Bacillus pseudomycoides), 바실러스 셀레니티레두센스(Bacillus selenitireducens), 엑시구오박테리움 시비리쿰(Exiguobacterium sibiricum), 락토바실러스 델브루엑키(Lactobacillus delbrueckii), 락토바실러스 살리바리우스(Lactobacillus salivarius), 마이크로실라 마리나(Microscilla marina), 부르콜데리알레스 박테리움(Burkholderiales bacterium), 폴라로모나스 나프탈레니보란스(Polaromonas naphthalenivorans), 폴라로모나스 종(Polaromonas sp.), 크로코스파에라 와트소니(Crocosphaera watsonii), 시아노테스 종(Cyanothece sp .), 마이크로시스티스 에어루기노사(Microcystis aeruginosa), 시네코코커스 종(Synechococcus sp .), 아세토할로비움 아라바티쿰(Acetohalobium arabaticum), 암모니펙스 데겐시(Ammonifex degensii), 칼디셀룰로시럽토르 벡시(Caldicelulosiruptor becscii), 칸디다투스 데술포루디스(Candidatus Desulforudis), 클로스트리디움 보툴리눔(Clostridium botulinum), 클로스트리디움 디피실레(Clostridium difjicile), 피네골디아 마그나(Finegoldia magna), 나트라나에어로비우스 써모필루스(Natranaerobius thermophilus), 펠로토마쿨룸 써모프로피오니쿰(Pelotomaculum thermopropionicum), 액시디티오바실러스 칼두스(Acidithiobacillus caldus), 액시디티오바실러스 페로옥시단스(Acidithiobacillus ferrooxidans), 알로크로마티움 비노섬(Allochromatium vinosum), 마리노박터 종(Marinobacter sp.), 니트로소코쿠스 할로필루스(Nitrosococcus halophilus), 니트로소코쿠스 와트소니(Nitrosococcus watsoni), 슈도알테로모나스 할로플랑크티스(Pseudoalteromonas haloplanktis), 크테도노박터 라세미페르(Ktedonobacter racemifer), 메타노할로비움 에베스티가툼(Methanohalobium evestigatum), 아나바에나 바리아빌리스(Anabaena variabilis), 노둘라리아 스푸미게나(Nodularia spumigena), 노스톡 종(Nostoc sp.), 아르트로스피라 막시마(Arthrospira maxima), 아르트로스피라 플라텐시스(Arthrospira platensis), 아르트로스피라 종(Arthrospira sp .), 링비아 종(Lyngbya sp .), 마이크로콜레우스 크토노플라스테스(Microcoleus chthonoplastes), 오실라토리아 종(Oscillatoria sp .), 페트로토가 모빌리스(Petrotoga mobilis), 써모시포 아프리카누스(Thermosipho africanus), 아카리오클로리스 마리나(Acaryocloris marina) 또는 알려진 PAM 서열을 갖는 CRISPR 뉴클레아제를 코딩하는 종으로부터 유래될 수 있다. 배양되지 않은 박테리아에 의해 코딩된 CRISPR 뉴클레아제도 본 발명의 맥락에서 사용될 수 있다. (Burstein et al. Nature, 2017 참조) 공지된 PAM 서열을 갖는 CRISPR 단백질의 변이체, 예를 들어 SpCas9 D1135E 변이체, SpCas9 VQR 변이체, SpCas9 EQR 변이체 또는 SpCas9 VRER 변이체가 또한 본 발명의 맥락에서 사용될 수 있다.
따라서, CRISPR 시스템의 RNA 가이드 DNA 뉴클레아제, 예를 들면, Cas9 단백질 또는 변형된 Cas9 또는 Cas9의 상동체 또는 오르토로그(ortholog), 또는 기타 타입의 CRISPR 시스템에 속하는 기타 RNA 가이드 DNA 뉴클레아제, 예를 들면, Cpf1 및 그의 상동체 및 오르토로그가 본 발명의 조성물에서 사용될 수 있다. 추가적인 CRISPR 뉴클레아제, 예를 들어, 각각 참조에 의해 본원에 포함된, PCT 국제 출원 공개 WO2020/223514 및 WO2020/223553에 기재된 뉴클레아제도 사용될 수 있다.
특정 구체예에서, CRISPR 뉴클레아제는 천연 Cas 단백질의 "기능적 유도체"일 수 있다. 원형(native) 서열 폴리펩티드의 "기능적 유도체"는 원형 서열 폴리펩티드와 공통인 정성적 생물학적 특성을 갖는 화합물이다. "기능적 유도체"는 원형 서열의 단편, 원형 서열 폴리펩티드 및 그의 단편의 유도체를 포함하나, 이에 한정되지 않으나, 단, 이들은 상응하는 원형 서열 폴리펩티드와 공통적인 생물학적 활성을 갖는다. 본원에서 고려되는 생물학적 활성은 DNA 기질을 단편으로 가수분해하는 기능적 유도체의 능력이다. 용어 "유도체(derivative)"는 폴리펩티드의 아미노산 서열 변이체, 공유결합성 변형(covalent modification) 및 이들의 융합을 모두 포함한다. Cas 폴리펩티드 또는 그의 단편의 적합한 유도체는 Cas 단백질 또는 그의 단편의 돌연변이체, 융합체, 공유결합성 변형을 포함하나, 이에 한정되지 않는다. 유도체는 CRISPR 닉카아제(nickase), 촉매적으로 불활성이거나 "데드(dead)" CRISPR 뉴클레아제, 및 CRISPR 뉴클레아제 또는 그의 유도체와 염기 에디터(base editor) 또는 레트로트랜스포존(retrotransposon)과 같은 기타 효소의 융합체를 포함하나, 이에 한정되지 않는다. 예를 들어, Anzalone et al. (2019) 및 PCT 국제출원 PCT/US2020/037560을 참조한다.
Cas 단백질 또는 그의 단편, 및 Cas 단백질 또는 그 단편의 유도체를 포함한, Cas 단백질은 세포로부터 수득될 수 있거나, 화학적으로 합성되거나, 이 두 절차의 조합에 의해 합성될 수 있다. 세포는 자연적으로 Cas 단백질을 생산하는 세포일 수 있거나 자연적으로 Cas 단백질을 생산하고 더 높은 발현 수준으로 내인성 Cas 단백질을 생산하거나, 내인성 Cas와 동일하거나 또는 다른 Cas를 코딩하는 것인 외인성으로 도입된 핵산으로부터 Cas 단백질을 생산하도록 유전적으로 조작된 세포일 수 있다. 일부 경우에, 세포는 자연적으로 Cas 단백질을 생성하지 않고, Cas 단백질을 생성하도록 유전적으로 조작된다.
일부 구체예에서, CRISPR 뉴클레아제는 Cpf1이다. Cpf1은 T가 풍부한 프로토스페이서 인접 모티프를 이용하는 단일 RNA 가이드 엔도뉴클레아제이다. Cpf1은 점착성(staggered) DNA 이중가닥 절단을 통해 DNA를 절단한다. 액시드아미노코커스(Acidaminococcus)와 라크노스피라세애(Lachnospiraceae)의 두 Cpf1 효소는 인간 세포에서 효율적인 게놈 편집 활성을 보이는 것으로 확인되었다. (Zetsche et al., 2015 참조).
따라서 타입 II CRISPR 시스템의 RNA 가이드 DNA 뉴클레아제, 예를 들면, Cas9 단백질 또는 변형된 Cas9 또는 Cas9의 상동체, 오르토로그 또는 변이체, 또는 기타 타입의 CRISPR 시스템에 속하는 기타 RNA 가이드 DNA 뉴클레아제, 예를 들면, Cpf1, 그의 상동체, 오르토로그, 또는 변이체가 본 발명에서 사용될 수 있다.
일부 구체예에서, 가이드 분자는 새롭거나 개선된 특성(예를 들어, 분해로부터의 개선된 안정성, 개선된 혼성화 에너지, 또는 RNA 가이드 DNA 뉴클레아제와의 개선된 결합 특성)을 부여하는 하나 이상의 화학적 변형을 포함한다. 적합한 화학적 변형은 변형된 염기, 변형된 당 모이어티, 또는 변형된 뉴클레오시드간 결합(inter-nucleoside linkage)을 포함하나, 이에 한정되지 않는다. 적합한 화학적 변형의 비한정적 예는: 4-아세틸시티딘, 5-(카르복시히드록시메틸)우리딘, 2'-O-메틸시티딘, 5-카르복시메틸아미노메틸-2-티오우리딘, 5-카르복시메틸아미노메틸우리딘, 디히드로우리딘, 2'-O-메틸슈도우리딘, "베타, D-갈락토실퀘오신(beta, D-galactoqueuosin)", 2'-O-메틸구아노신, 이노신, N6-이소펜테닐아데노신, 1-메틸아데노신, 1-메틸슈도우리딘, 1-메틸구아노신, 1-메틸이노신, "2,2-디메틸구아노신", 2-메틸아데노신, 2-메틸구아노신, 3-메틸시티딘, 5-메틸시티딘, N6-메틸아데노신, 7-메틸구아노신, 5-메틸아미노메틸우리딘, 5-메톡시아미노메틸-2-티오우리딘, "베타, D-만노실퀘오신", 5-메톡시카르보닐메틸-2-티오우리딘, 5-메톡시카르보닐메틸우리딘, 5-메톡시우리딘, 2-메틸티오-N6-이소펜테닐아데노신, N-((9-베타-D-리보푸라노실-2-메틸티오퓨린-6-일)카르바모일)트레오닌, N-((9-베타-D-리보푸라노실퓨린-6-일)N-메틸카르바모일)트레오닌, 우리딘-5-옥시아세트산-메틸에스테르, 우리딘-5-옥시아세트산, 와이부톡소신(wybutoxosine), 퀘오신(queuosin), 2-티오시티딘, 5-메틸-2-티오우리딘, 2-티오우리딘, 4-티오우리딘, 5-메틸우리딘, N-((9-베타-D-리보푸라노실퓨린-6-일)-카르바모일)트레오닌, 2'-O-메틸-5-메틸우리딘, 2'-O-메틸우리딘, 와이부토신(wybutosine), "3-(3-아미노-3-카르복시-프로필)우리딘, (acp3)u", 2'-0-메틸(M), 3'-포스포로티오에이트(MS), 3'-티오PACE(MSP), 슈도우리딘 또는 1-메틸 슈도-우리딘을 포함한다. 각각의 가능성은 본 발명의 별개의 구체예를 나타낸다.
C3 대립유전자를 표적으로 하는 가이드 서열
DNA 부위를 표적화하는데 활용되는 가이드 서열 부분을 포함하는 임의의 주어진 RNA 분자는 RNA 분자의 분해, 제한된 활성, 무활성(no activity) 또는 오프타겟(off-target) 효과를 초래할 수 있다. 따라서, 유전자의 주어진 DNA 부위를 표적화하기 위해서는 적합한 가이드 서열 부분이 필요하다.
본 발명에 의해, 적어도 하나의 C3 대립유전자를 표적화하고, 상기 적어도 하나의 대립유전자에 C3 프로모터의 제어 하에 발현될 뉴클레오티드 서열을 도입하고, 그에 의해 장애 또는 질환을 치료하기 위한 가이드 서열 부분의 신규한 세트가 확인되었다. 바람직하게는, 두 C3 대립유전자 모두를 표적화할 수 있는 비차별적 RNA 분자가 표적화를 위해 사용된다.
그러나, 특정 C3 대립유전자를 표적화할 수 있는 RNA 분자도 고려된다. 예를 들어, RNA 분자의 가이드 서열 부분은 하나의 C3 대립유전자에 존재하는 특정 SNP를 표적화할 수 있다. 특히, 주어진 유전자가 수천 개의 SNP가 포함할 수 있다. 유전자의 각 SNP를 표적화하기 위해 25개의 염기쌍 표적 창(window)을 활용하려면 수십만 개의 가이드 서열이 필요하다.
본 개시는 C3 대립유전자를 특이적으로 표적화할 수 있는 가이드 서열 부분을 제공한다. 일부 구체예에서, C3 대립유전자는 표적화되지만, 나머지 비표적화 C3 대립유전자는 변형되지 않은 상태로 남는다. 본 발명의 일부 가이드 서열은 C3 대립유전자를 특이적으로 구별하도록 설계되고, 그렇게 될 가능성이 높다. 일부 구체예에서, C3 대립유전자 둘 모두가 표적화된다. C3 서열을 표적으로 하는 모든 가능한 가이드 서열 중에서, 본원에 개시된 특정 가이드 서열은 개시된 구체예와 함께 기능하기에 특히 효과적이다.
간략하게, 가이드 서열은 다음과 같은 특성을 가질 수 있다: (1) 일반 집단, 특정 인종 집단 또는 환자 집단에서 출현률(prevalence)이 1% 초과인 SNP/삽입/삭제/인델(indel)로서, 동일한 집단에서 상기 SNP/삽입/결실/인델 이형접합성(heterozygosity) 비율이 1% 초과인 것인 SNP/삽입/삭제/인델을 표적화하고; (2) 유전자의 일부에 근접한 SNP/삽입/결실/인델의 위치, 예를 들어 유전자의 임의의 부분, 예를 들어 프로모터, UTR, 엑손 또는 인트론의 5k 염기 내를 표적화한다. 일부 구체예에서, 일반 집단, 특정 인종 집단 또는 환자 집단에서 상기 SNP/삽입/결실/인델의 출현률은 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% 또는 15% 초과이고, 동일한 집단에서 상기 SNP/삽입/결실/인델 이형접합성 비율은 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% 또는 15%를 초과한다. 각 가능성은 별개의 실시예를 나타내며 자유롭게 조합될 수 있다.
본 발명의 일부 구체예에서, RNA 분자는 C3 유전자에 외인성 뉴클레오티드 서열을 도입하거나 또는 넉인하기 위해 C3 유전자의 부위를 표적화하기 위해 이용된다. 일부 구체예에서, 상기 부위는 SNP 위치이다. 일부 구체예에서, 상기 부위의 위치는 의도된 넉인 부위 근처, 바람직하게는 개시 코돈 또는 정지 코돈 근처, 바람직하게는 개시 코돈 또는 정지 코돈의 150 bp(base pairs) 이내이다. 일부 구체예에서, 상기 부위는 표적화된 C3 대립유전자 또는 대립유전자들의 첫 번째 코딩 엑손 다음에 오는 첫 번째 인트론 내에 위치한다. 일부 구체예에서, 상기 부위는 표적화된 C3 대립유전자의 인트론 1 내에 위치한다.
본 발명의 가이드 서열 부분은 (1) 표적화된 C3 유전자에 대해 이형접합성 SNP를 표적화하고; (2) 상기 유전자의 상류 또는 하류 위치(공통 서열 또는 SNP)를 표적화하며; (3) 일반 집단, 특정 인종 집단, 또는 환자 집단에서 1% 초과의 SNP/삽입/결실/인델 출현률을 갖는 SNP를 표적화하고; (4) 30% 초과 85% 미만의 구아닌-시토신 함량을 가지며; (5) 7개 이상의 티민/우라실, 구아닌, 시토신 또는 아데닌의 반복을 갖지 않고; (6) 동일한 PAM 서열과의 불일치가 전혀 없는 추가적인 표적이 게놈에 존재하지 않는다. 본 발명의 가이드 서열은 전술된 기준을 만족시키고, 표적화된 대립유전자와 그에 상응하는 비-표적화 대립유전자를 구별할 가능성이 가장 높다.
세포로의 전달
본원에 기술된 조성물은 임의의 적합한 수단에 의해 표적 세포에 전달될 수 있다. 본 발명의 조성물은 임의의 포유동물 세포, 바람직하게는 간 세포를 포함한, C3 대립유전자를 포함하고 및/또는 발현하는 임의의 세포에 표적화될 수 있다. 예를 들어, 일 구체예에서, C3 대립유전자를 특이적으로 표적화하는 RNA 분자는 표적 세포로 전달되고, 상기 표적 세포는 HSC, 헤파토사이트, 또는 기타 간 세포이다. 세포로의 전달은 시험관내, 생체외, 생체내에서 수행될 수 있다. 또한, 본원에 기술된 핵산 조성물은 DNA 분자, RNA 분자, 리보핵단백질(ribonucleoprotein: RNP), 핵산 벡터, 또는 이들의 임의의 조합 중 하나 이상으로서 전달될 수 있다.
일부 구체예에서, 본원에 기술된 조성물의 생체내 전달 방법은 렌티바이러스, 아데노-관련 바이러스(AAV) 또는 나노입자에 의한 전달을 포함한다. 일부 구체예에서, 본원에 기술된 조성물의 생체내 전달 방법은 렌티바이러스, 아데노-관련 바이러스(AAV) 또는 나노입자에 의한 전달을 포함한다. 상기 조성물은 RNP 조성물의 형태일 수 있다. 따라서, 전달은 개체, 예를 들어 간 관련 장애를 앓고 있는 개체 내의 간 세포로 생체내에서 이루어질 수 있다.
일부 구체예에서, 본원에 기재된 조성물 중 어느 하나는 생체외 세포에 전달된다. 일부 구체예에서, 상기 세포는 줄기 세포이다. 일부 구체예에서, 상기 세포는 간 세포이다. 일부 구체예에서, 상기 세포는 헤파토사이트(hepatocyte)이다. 일부 구체예에서, 상기 세포는 iPS 유래 헤파토사이트이다. 상기 조성물은 전기천공, 바이러스 형질도입, 나노입자 전달, 리포좀 등을 포함하나, 이에 한정되지 않는 임의의 공지된 생체외 전달 방법에 의해 세포에 전달될 수 있다. 상기 조성물은 RNP 조성물의 형태일 수 있다. 추가적인 상세한 전달 방법이 이 섹션 전반에 걸쳐 설명된다.
일부 구체예에서, 선택적으로 간엽(liver lobe) 또는 헤파토사이트 세포는 예를 들어 생검을 수행하여 개체로부터 수득된다. 그 후, 수득된 세포는 본원에 기술된 조성물의 생체외 전달에 의해 유전적으로 변형될 수 있다. 변형된 세포는 엽 이식 또는 헤파토사이트 이식을 수행함으로써 개체에게 재도입될 수 있다.
일부 구체예에서, 본원에 기술된 조성물의 RNA 분자는 화학적 변형을 포함한다. 적합한 화학적 변형의 비한정적 예는 2'-O-메틸(M), 2'-O-메틸, 3'포스포로티오에이트(MS) 또는 2'-O-메틸, 3'티오PACE(MSP), 슈도우리딘, 및 1-메틸 슈도-우리딘을 포함한다. 각각의 가능성은 본 발명의 별도의 실시예를 나타낸다.
임의의 적합한 바이러스 벡터 시스템이 핵산 조성물, 예를 들면, 본 발명의 RNA 조성물을 전달하는 데 사용될 수 있다. 통상적인 바이러스 및 비-바이러스 기반 유전자 전달 방법이 핵산을 도입하고 조직을 표적화하기 위해 사용될 수 있다. 특정한 구체예에서, 핵산은 생체내(in vivo) 또는 생체외(ex vivo) 유전자 치료법 용도를 위해 투여된다. 비-바이러스 벡터 전달 시스템은 네이키드(naked) 핵산, 및 리포좀 또는 폴록사머와 같은 전달 비히클과 복합체화된 핵산을 포함한다. 유전자 치료법 절차에 대한 검토를 위해, Anderson (1992); Nabel & Felgner (1993); Mitani & Caskey (1993); Dillon (1993); Miller (1992); Van Brunt (1988); Vigne (1995); Kremer & Perricaudet (1995); Haddada et al. (1995); 및 Yu et al., (1994)을 참조한다.
핵산 및/또는 단백질의 비-바이러스 전달의 방법은 전기천공, 리포펙션, 미세주사, 바이올리스틱(biolistic), 입자 총 가속화, 비로좀(virosome), 리포좀, 면역리포좀, 지질 나노입자(LNP), 다중양이온 또는 지질:핵산 접합체, 인공비리온, 및 핵산의 작용체-증강 흡수(agent-enhanced uptake)를 포함하거나, 박테리아 또는 바이러스(예를 들어, 아그로박테리움(Agrobacterium), 리조비움 종 NGR234(Rhizobium sp. NGR234), 시노리조보이움멜릴로티(Sinorhizoboiummeliloti), 메조리조비움 로티(Mesorhizobium loti), 담배 모자이크 바이러스(TMV), 감자 바이러스 X, 콜리플라워 모자이크 바이러스(cauliflower mosaic virus) 및 카싸바 베인 모자이크 바이러스(cassava vein mosaic virus)에 의해 식물 세포로 전달될 수 있다. (예를 들어, Chung et al. (2006)을 참조한다). 예를 들어, Sonitron 2000 시스템(Rich-Mar)을 사용한 초음파천공(sonoporation)이 또한 핵산의 전달에 사용될 수 있다. 단백질 및/또는 핵산의 양이온성-지질 매개 전달이 또한 생체내, 생체외, 또는 시험관내 전달 방법으로서 고려된다. (Zuris et al. (2015);, Coelho et al. (2013); Judge et al. (2006); 및 Basha et al. (2011)을 참조한다).
비-바이러스 벡터, 예를 들면, 트랜스포존-기반 시스템(transposon-based system), 예를 들어 재조합 Sleeping Beauty 트랜스포존 시스템 또는 재조합 PiggyBac 트랜스포존 시스템이 또한 표적 세포로 전달될 수 있고, 표적 세포에서 조성물의 분자의 폴리뉴클레오티드 서열 또는 조성물의 분자를 코딩하는 폴리뉴클레오티드 서열의 전위(transposition)에 이용될 수 있다.
추가적인 예시적 핵산 전달 시스템은 Amaxa® Biosystems(독일 쾰른 소재), Maxcyte, Inc.(미국 메릴랜드주 록빌 소재), BTX Molecular Delivery Systems(미국 매사추세츠주 홀리스턴 소재) 및 Copernicus Therapeutics Inc.,(예를 들어, 미국 특허 제6,008,336호 참조)에 의해 제공되는 것을 포함한다. 리포펙션은, 예를 들어 미국 특허 제5,049,386호, 미국 특허 제4,946,787호; 및 미국 특허 제4,897,355호에 기재되어 있으며, 리포펙션 시약은 상업적으로 판매된다(예를 들어, Transfectam.TM., Lipofectin.TM. 및 Lipofectamine.TM. RNAiMAX). 폴리뉴클레오티드의 효율적인 수용체-인식 리포펙션에 적합한 양이온성 및 중성 지질은 PCT 국제 공개 WO/1991/017424 및 WO/1991/016024에 개시된 것들을 포함한다. 전달은 세포(생체외 투여) 또는 표적 조직(생체내 투여)에 대한 것일 수 있다.
면역지질 복합체와 같은 표적화된 리포좀을 포함한, 지질:핵산 복합체의 제조는 통상의 기술자에게 잘 알려져 있다(예를 들어, Crystal, Science (1995); Blaese et al., (1995); Behr et al., (1994); Remy et al., (1994); Gao 및 Huang(1995); Ahmad 및 Allen(1992); 미국 특허번호 4,186,183; 4,217,344; 4,235,871; 4,261,975; 4,485,054; 4,501,728; 4,774,085; 4,837,028; 및 4,946,787을 참조한다).
추가적인 전달 방법은 전달될 핵산을 EnGeneIC 전달 비히클(EDV) 내로 패키징하는 것의 사용을 포함한다. 이들 EDV는 이중특이적 항체를 사용하여 표적 조직으로 특이적으로 전달되며, 상기 항체의 하나의 암(arm)은 표적 조직에 대한 특이성을 갖고, 나머지 암은 EDV에 대한 특이성을 갖는다. 상기 항체가 EDV를 표적 세포 표면으로 가져간 다음, EDV가 엔도시토시스(endocytosis)에 의해 세포 내로 들어간다. 일단 세포 안에 들어가면, 내용물이 방출된다(MacDiamid et al., 2009 참조).
전달 비히클은 당업계에서 알려진 기타 전달 비히클 중에서, 박테리아, 바람직하게는 비-병원성, 비히클, 나노입자, 엑소좀, 미세소포(microvesicle), 유전자총 전달, 예를 들어 "유전자총"을 통해 세포 내로 발사되는 금 입자로의 조성물의 부착에 의한 전달, 렌티바이러스, AAV, 및 레트로바이러스를 포함하지만 이에 제한되지 않는 바이러스 비히클, 바이러스-유사 입자(VLP), 대형 VLP(LVLP: large virus-like particle), 렌티바이러스-유사 입자, 트랜스포존, 바이러스 벡터, 네이키드 벡터, DNA, 또는 RNA를 포함하나, 이에 한정되지 않는다.
CRISPR 뉴클레아제 및/또는 CRISPR 뉴클레아제를 코딩하는 폴리뉴클레오티드, 및 선택적으로 추가적인 뉴클레오티드 분자 및/또는 추가적인 단백질 또는 펩티드의 전달은 단일 전달 비히클 또는 방법 또는 상이한 전달 비히클 또는 방법의 조합을 이용하여 수행될 수 있다. 예를 들어, CRISPR 뉴클레아제는 LNP를 이용하여 세포에 전달될 수 있고, crRNA 분자 및 tracrRNA 분자는 AAV를 이용하여 세포에 전달될 수 있다. 대안적으로, CRISPR 뉴클레아제는 AAV 입자를 이용하여 세포에 전달될 수 있고, crRNA 분자 및 tracrRNA 분자는 별개의 AAV 입자를 이용하여 세포에 전달될 수 있으며, 이는 크기 제한으로 인해 유리할 수 있다.
핵산의 바이러스 매개 전달을 위한 RNA 또는 DNA 바이러스 기반 시스템의 사용은 신체의 특정 세포에 바이러스를 표적화하고 바이러스 페이로드(viral payload)를 핵으로 수송하기 위한 고도로 진화된 프로세스를 이용한다. 바이러스 벡터는 환자에게 직접 투여될 수 있거나(생체내) 시험관내에서 세포를 치료하는 데 사용될 수 있고 변형된 세포가 환자에게 투여된다(생체외). 통상적인 핵산의 전달을 바이러스 기반 시스템은 유전자 전달을 위한 재조합 레트로바이러스, 렌티바이러스, 아데노바이러스, 아데노-연관 바이러스, 백시니아 바이러스 및 단순 포진 바이러스(herspes simplex virus) 벡터를 포함하나 이에 한정되지 않는다. 본원에 기재된 RNA 조성물의 전달을 위해서 RNA 바이러스가 이용될 수 있다. 추가적으로, 높은 형질도입(transduction) 효율이 다수의 다양한 세포 유형 및 표적 조직에서 관찰되었다. 본 발명의 핵산은 비-통합 렌티바이러스(non-integrating lentivirus)에 의해 전달될 수 있다. 선택적으로, 렌티바이러스를 이용한 RNA 전달이 이용된다. 선택적으로, 렌티바이러스는 뉴클레아제의 mRNA 및 가이드의 RNA를 포함한다. 선택적으로, 렌티바이러스는 뉴클레아제의 mRNA, 가이드의 RNA 및 공여체 주형을 포함한다. 선택적으로, 렌티바이러스는 뉴클레아제 단백질, 가이드 RNA를 포함한다. 선택적으로, 렌티바이러스는 뉴클레아제 단백질, 가이드 RNA, 및/또는 예를 들어, 상동성 기반 복구를 통한, 유전자 편집을 위한 공여체 주형을 포함한다. 선택적으로, 렌티바이러스는 뉴클레아제의 mRNA, DNA-표적화 RNA 및 tracrRNA를 포함한다. 선택적으로, 렌티바이러스는 뉴클레아제의 mRNA, DNA-표적화 RNA 및 tracrRNA, 및 공여체 주형을 포함한다. 선택적으로, 렌티바이러스는 뉴클레아제 단백질, DNA-표적화 RNA 및 tracrRNA를 포함한다. 선택적으로, 렌티바이러스는 뉴클레아제 단백질, DNA-표적화 RNA, 및 tracrRNA, 및, 예를 들어 상동성 기반 복구를 통한, 유전자 편집을 위한 공여체 주형을 포함한다.
전술된 바와 같이, 본원에 기재된 조성물은 비-통합 렌티바이러스 입자 방법, 예를 들어 LentiFlash®시스템을 사용하여 표적 세포로 전달될 수 있다. 이러한 방법은 표적 세포로의 RNA의 전달이 표적 세포 내부에서 본원에 기재된 조성물의 조립(assembly)을 초래하도록, 표적 세포 내로 mRNA 또는 다른 유형의 RNA를 전달하기 위해 이용될 수 있다. 또한 PCT 국제 공개 WO2013/014537, WO2014/016690, WO2016185125, WO2017194902, 및 WO2017194903을 참조한다.
레트로바이러스의 친화성(tropism)은 외래 외피 단백질을 통합하여 표적 세포의 잠재적인 표적 집단을 확장함으로써 변경될 수 있다. 렌티바이러스 벡터는 비-분열(non-dividing) 세포를 형질도입하거나 감염시킬 수 있고 일반적으로 높은 바이러스 역가를 생성할 수 있는 레트로바이러스 벡터이다. 레트로바이러스 유전자 전달 시스템의 선택은 표적 조직에 따라 다르다. 레트로바이러스 벡터는 최대 6-10 kb의 외래 서열의 패키징 능력을 갖는 시스-작용 긴 말단 반복(long terminal repeat: LTR)으로 구성된다. 최소 시스-작용 LTR이 벡터의 복제 및 패키징에 충분하며, 이는 영구적인 이식 유전자(transgene) 발현을 제공하기 위해 치료 유전자를 표적 세포에 통합시키는데 사용된다. 널리 사용되는 레트로바이러스 벡터는 MuLv(murine leukemia virus), GaLV(gibbon ape leukemia virus), SIV(Simian Immunodeficiency virus), HIV(Human Immunodeficiency virus), 및 이들의 조합에 기반한 것들을 포함한다(예를 들어, Buchschacher et al.( 1992), Johann 등(1992), Sommerfelt 등(1990), Wilson 등(1989), Miller 등(1991), PCT 국제 공개 번호. WO/1994/026877A1 참조).
적어도 6개의 바이러스 벡터 접근법이 현재 임상 시험에서 유전자 전달을 위해 이용 가능하며, 이는 형질도입체(transducing agent)를 생성하기 위해 헬퍼 세포주 내로 삽입된 유전자에 의한 결함 벡터(defective vector)의 보완을 포함하는 접근법을 이용한다.
pLASN 및 MFG-S는 임상 시험에서 사용된 레트로바이러스 벡터의 예이다(Dunbar et al., 1995; Kohn et al., 1995; Malech et al., 1997 참조). PA317/pLASN은 유전자 치료법 시험에서 사용된 최초의 치료용 벡터이었다(Blaese et al., 1995). 50% 이상의 형질도입 효율이 MFG-S 패키징된 벡터에서 관찰되었다. (Ellem 등, (1997); Dranoff 등, 1997).
패키징 세포는 숙주 세포를 감염시킬 수 있는 바이러스 입자를 형성하는 데 사용된다. 이러한 세포는 아데노바이러스, AAV를 패키징하는 293 세포, 및 레트로바이러스를 패키징하는 Psi.2 세포 또는 PA317 세포를 포함한다. 유전자 치료법에서 사용되는 바이러스 벡터는 일반적으로 바이러스 입자 내로 핵산 벡터를 패키징하는 생산체 세포주(producer cell line)에 의해 생성된다. 벡터는 전형적으로 패키징 및 숙주 내로의 후속 통합(적용 가능한 경우)을 위해 요구되는 최소 바이러스 서열을 포함하며, 다른 바이러스 서열은 발현될 단백질을 코딩하는 발현 카세트에 의해 대체된다. 결여된(missing) 바이러스 기능은 패키징 세포주에 의해 트랜스로 공급된다. 예를 들어, 유전자 치료법에서 사용되는 AAV 벡터는 전형적으로 패키징 및 숙주 게놈 내로의 통합을 위해 요구되는 AAV 게놈으로부터의 ITR(inverted terminal repeat) 서열만을 보유한다. 바이러스 DNA는 세포주에서 패키징되며, 이는 나머지 AAV 유전자, 즉 rep 및 cap을 코딩하나, ITR 서열은 없는 헬퍼 플라스미드를 포함한다. 상기 세포주는 또한 헬퍼로서 아데노바이러스로 감염된다. 헬퍼 바이러스는 AAV 벡터의 복제 및 헬퍼 플라스미드로부터 AAV 유전자의 발현을 촉진시킨다. 헬퍼 플라스미드는 ITR 서열의 부재로 인해 유의한 양으로 패키징되지 않는다. 아데노바이러스에 의한 오염은, 예를 들어 아데노바이러스가 AAV보다 더 민감한 열 처리에 의해 감소될 수 있다. 추가적으로, AAV는 바큘로바이러스(baculovirus) 시스템을 사용하여 임상 규모로 생산될 수 있다(미국 특허 번호 제7,479,554호 참조).
여러 유전자 치료법 적용에서, 유전자 치료법 벡터는 특정 조직 유형으로 고도의 특이성으로 전달되는 것이 바람직하다. 따라서, 바이러스 벡터는 리간드를 바이러스의 외부 표면 상의 바이러스 코트(viral coat) 단백질과의 융합 단백질로서 발현시킴으로써 주어진 세포 유형에 대해 특이성을 갖도록 변형될 수 있다. 리간드는 목적 세포 유형의 세포 상에 존재하는 것으로 알려진 수용체에 대해 친화도를 갖도록 선택된다. 예를 들어, Han et al. (1995)은 MMLV(Molony murine leukemia virus)가 gp70에 융합된 인간 헤레귤린(heregulin)을 발현하도록 변형될 수 있고, 재조합 바이러스가 인간 표피 성장 인자 수용체를 발현하는 특정 인간 유방암 세포를 감염시킨다는 것을 보고하였다. 이 원리는 다른 바이러스-표적 세포 쌍으로 확장될 수 있고, 여기서 표적 세포는 수용체를 발현하고 바이러스는 세포-표면 수용체에 대한 리간드를 포함하는 융합 단백질을 발현한다. 예를 들어, 사상 파아지(filametous phage)는 실질적으로 임의의 선택된 세포 수용체에 대해 특이적 결합 친화도를 갖는 항체 단편(예를 들어, FAB 또는 Fv)을 표시하도록 조작될 수 있다. 전술된 내용은 주로 바이러스 벡터에 적용되지만, 동일한 원리가 비-바이러스 벡터에 적용될 수 있다. 이러한 벡터는 특정 표적 세포에 의한 흡수에 유리한 특정 흡수 서열을 포함하도록 조작될 수 있다.
유전자 치료법 벡터는 하기 기재된 바와 같이, 전형적으로 전신 투여(예를 들어, 유리체내, 정맥내, 복강내, 근육내, 진피하, 또는 두개내 주입) 또는 국소 적용에 의해, 개별 환자로의 투여에 의해 생체내 전달될 수 있다. 대안적으로, 벡터는 개별 환자로부터 외식된 세포(예를 들어, 림프구, 골수 흡입물, 조직 생검)와 같은 생체외 세포 또는 범용 공여체 조혈 줄기 세포(universal donor hematopoietic stem cell)로 전달될 수 있고, 선택적으로, 벡터를 내포하는 세포에 대한 선택 후에, 환자 내로의 세포의 재이식이 이어질 수 있다. 벡터가 포함된 세포를 선택합니다. 비한정적인 예시적 생체외 접근법은 배양을 위해 환자로부터 조직(예: 말초 혈액, 골수 및 비장)의 채취, 배양된 세포(예: 조혈 줄기 세포)로의 핵산 전달, 및 뒤이은 환자의 표적 조직(예: 골수, 비장)으로의 세포의 이식을 포함할 수 있다. 일부 구체예에서, 줄기 세포 또는 조혈 줄기 세포는 생존력 증강제(viability enhancer)로 추가로 처리될 수 있다.
진단, 연구, 또는 유전자 치료법(예를 들어, 숙주 유기체 내로의 형질감염된 세포의 재주입을 통한 유전자 치료법)을 위한 생체외 세포 형질감염은 통상의 기술자에게 잘 알려져 있다. 바람직한 구체예에서, 세포를 대상 유기체로부터 단리하고, 핵산 조성물로 형질감염시키고, 대상 유기체(예를 들어, 환자) 내로 다시 재주입한다. 생체외 형질감염에 적합한 다양한 세포 유형은 통상의 기술자에게 잘 알려져 있다(예를 들어, 환자로부터 세포를 어떻게 단리하고 배양하는지의 논의에 대해, Freshney, "Culture of Animal Cells, A Manual of Basic Technique and Specialized Applications (6th edition, 2010) 및 그에서 인용된 참조문헌 참조).
적합한 세포는 진핵 세포 및/또는 세포주를 포함하나, 이에 한정되지 않는다. 이러한 세포 또는 이러한 세포로부터 생성된 세포주의 비-한정적 예는 COS, CHO(예를 들어, CHO--S, CHO-K1, CHO-DG44, CHO-DUXB11, CHO-DUKX, CHOK1SV), VERO, MDCK, WI38, V79, B14AF28-G3, BHK, HaK, NSO, SP2/0-Ag14, HeLa, HEK293(예를 들어, HEK293-F, HEK293-H, HEK293-T), 및 perC6 세포, 임의의 식물 세포(분화 또는 미분화), 및 곤충 세포, 예컨대, 스포돕테라푸기페르다(Spodopterafugiperda(Sf)), 또는 진균 세포, 예컨대, 사카로마이세스(Saccharomyces), 피키아(Pichia) 및 스키조사카로마이세스(Schizosaccharomyces)를 포함한다. 특정 구체예에서, 세포주는 CHO-K1, MDCK 또는 HEK293 세포주이다. 추가적으로, 1차 세포가 단리되고, 가이드 뉴클레아제 시스템(guided nuclease system)(예를 들어, CRISPR/Cas)에 의한 처리 후 치료대상 개체 내로의 재도입을 위해 생체외에서 이용될 수 있다. 적합한 1차 세포는 말초혈액 단핵 세포(PBMC), 및 CD4+ T 세포 또는 CD8+ T 세포와 같은 기타 혈액 세포 서브세트를 포함하나, 이에 한정되지 않는다. 적합한 세포는 또한 예로서, 배아 줄기 세포, 유도된 다능성 줄기 세포, 조혈 줄기 세포(CD34+), 신경 줄기 세포 및 중간엽 줄기 세포와 같은 줄기 세포를 포함한다.
일 구체예에서, 줄기 세포는 세포 형질감염 및 유전자 치료법을 위한 생체외 절차에서 사용된다. 줄기 세포를 사용하는 장점은 줄기 세포가 인 비트로에서 다른 세포 유형으로 분화될 수 있거나 골수에서 생착될 포유동물(예컨대, 세포의 공여체) 내로 도입될 수 있다는 것이다. 인 비트로에서 CD34+ 세포를 GM-CSF, IFN-감마 및 TNF-알파와 같은 사이토카인을 사용하여 임상적으로 중요한 면역 세포 유형으로 분화시키는 방법이 알려져 있다(비한정적인 예로서, Inaba et al., 1992 참조).
줄기 세포는 공지된 방법을 이용하여 형질도입 및 분화를 위해 단리된다. 예를 들어, 줄기 세포는 원치 않는 세포, 예컨대, CD4+ 및 CD8+(T 세포), CD45+(panB 세포), GR-1(과립구), 및 Iad(분화 항원 제시 세포)에 결합하는 항체로 골수 세포를 패닝(panning)함으로써 골수 세포로부터 단리된다(비한정적 예로서, Inaba et al., 1992 참조). 변형된 줄기 세포가 또한 일부 구체예에서 사용될 수 있다.
치료용 핵산 조성물을 포함하는 벡터(예를 들어, 레트로바이러스, 리포좀 등)가 또한 생체내에서 세포의 형질도입을 위해 유기체에 직접 투여될 수 있다. 투여는 주사, 주입, 국소 적용(예: 점안액 및 크림) 및 전기천공을 포함하나, 이에 한정되지 않는, 분자를 혈액 또는 조직 세포와의 궁극적 접촉으로 도입하기 위해 일반적으로 사용되는 임의의 경로에 의한다. 이러한 핵산을 투여하는 적합한 방법이 이용 가능하고 통상의 기술자에게 잘 알려져 있으며, 하나 초과의 경로가 특정 조성물을 투여하는 데 이용될 수 있지만, 특정 경로가 종종 또 다른 경로보다 더 즉각적이고 더 효과적인 반응을 제공할 수 있다. 일부 구체예에 따르면, 조성물은 IV 주사를 통해 전달된다.
면역 세포(예를 들어, T-세포) 내로의 이식유전자의 도입에 적합한 벡터는 비-통합 렌티바이러스 벡터를 포함한다. 예를 들어, 미국 특허 공개 제2009/0117617호를 참조한다.
약학적으로 허용 가능한 담체는 부분적으로 투여되는 특정 조성물 및 조성물을 투여하는 데 사용되는 특정 방법에 의해 결정된다. 따라서, 하기에 기재된 바와 같이, 약학적 조성물의 매우 다양한 적합한 제형이 이용 가능하다(예를 들어, Remington's Pharmaceutical Sciences, 17th ed., 1989 참조).
일부 구체예에 따르면, RNA 가이드 DNA 뉴클레아제를 목적 유전자의 대립유전자 간에 다른 적어도 하나의 뉴클레오티드(예를 들어, SNP)를 포함하는 서열다(즉, 다른 C3 대립유전자에는 존재하지 않는 하나의 C3 대립유전자의 서열)에 결합/회합 및/또는 지시하는 RNA 분자가 제공된다. C3 대립유전자 사이의 임의의 서열 차이는 단일 C3 대립유전자를 변형 또는 편집하기 위해 본 발명의 RNA 분자에 의해 표적화될 수 있다.
개시된 조성물 및 방법은 또한 환자의 우성 유전 장애(dominant genetic disorder)를 치료하기 위한 약제의 제조에 사용될 수 있다.
C3 세이프 하버 넉인 방법의 작용 메커니즘
임의의 이론이나 메커니즘에 의해 구속되지 않으면서, 본 발명은 C3 대립유전자 내의 세이프 하버(safe harbor) 부위에 서열을 도입하고 이에 의해 도입된 서열의 발현을 C3 대립유전자의 프로모터에 의해 제어하도록 C3 대립유전자를 가공하기 위해 CRISPR 뉴클레아제를 적용하는데 이용될 수 있다. 도입된 서열의 발현은 이에 따라 간 관련 장애를 예방하거나 치료한다. 특정 가이드 서열이 표적화된 위치 및 사용되는 CRISPR 뉴클레아제의 타입에 근거하여(예를 들어, 요구되는 PAM 서열에 따라) 표 1로부터 선택될 수 있다.
C3 유전자는 염색체 19에 위치하며 보체 성분 3 단백질을 코딩한다. 공여체 분자는 넉인(knock-in)을 통해 원하는 뉴클레오티드 서열을 C3 세이프 하버 부위에 도입하는 데 사용될 수 있다. 따라서, 간 관련 질환을 예방하거나 치료하는 발현 산물을 코딩하는 임의의 서열이 C3 세이프 하버 부위에 도입될 수 있다. 따라서, 공여체 분자에 의해 코딩되는 서열의 비한정적 예는 ATP7B, A1AT, G6PC, SERPINA, LDLR, TTR, OTC - 오르니틴 트랜스카르바밀라아제, ASD - 아르기니노숙신산 합성효소, 아르기나아제, 아르기니노숙시나아제, 카르바모일 포스페이트 합성효소 및 N-아세틸글루타메이트 합성효소, 또는 그의 부분을 포함한다.
한 가지 전략은 C3 유전자의 첫 번째 인트론, 또는 첫 번째 코딩 엑손 다음에 오는 첫 번째 인트론에 뉴클레오티드의 서열을 넉인하는 것이다. 이 전략은 RNA 분자를 이용하여 CRISPR 뉴클레아제를 C3 유전자의 인트론 1에 표적화하여 이중가닥 절단을 매개한다. 절단(break)은 비조절 영역에서 매개되므로, 유전자의 발현에 영향을 미칠 것으로 예상되지 않는다. C3의 넉아웃 없이 서열의 넉인을 위해, 상기 서열은 녹인 공여체 카세트(knock-in donor cassette)에 스플라이싱 수용체(splicing acceptor: SA) 및 스플라이싱 공여체(splicing donor: SD) 요소를 첨가하여, 새로운 엑손(즉, 엑손 2)으로서 삽입된다. 또한, C3 유전자의 발현 중단을 방지하기 위해, 공여체 카세트는 삽입된 유전자의 C-말단에 적어도 하나의 2A 자가 절단(self-cleaving) 펩티드 및/또는 C3의 신호 펩티드를 포함하며, 이는 소포체(ER)에서 절단되어, C3 단백질로부터 삽입된 서열 단백질 발현 산물을 분리할 수 있게 한다.
또 다른 전략은 특정 C3 대립유전자의 첫 번째 인트론에 뉴클레오티드의 서열을 넉인하는 것이다. gnomAD에 따르면, C3 프레임시프트 돌연변이를 가진 건강한 개체들이 있고, 이는 반수체 기능부전(haploinsufficiency)이 문제가 되지 않는다는 것을 시사한다. 따라서, 넉인된 뉴클레오티드의 서열은 번역 종료 신호를 갖는 새로운 새로운 엑손으로 단일 C3 대립유전자에 삽입될 수 있으며, 이에 따라 하나의 C3 대립유전자의 발현만 넉아웃되고, 나머지 C3 대립유전자는 영향을 받지 않은 채 유지된다. C3 대립유전자-특이적 편집 사건은 예를 들어 인트론 1에 위치한 rs199713383과 같은 고빈도(highly frequent) SNP를 표적화하는 것에 의해 달성될 수 있다.
또 다른 전략은 정지 코돈을 교체하여 C3 유전자에 뉴클레오티드 서열을 넉인하는 것이다. 이 경우, 이중대립유전자 절단(biallelic break)은 정지 코돈의 하류 최대 150개 뉴클레오티드의 3'UTR 영역 또는 정지 코돈의 상류이나, 인트론 영역에서 매개된다. 이러한 영역 중 절단의 위치는 C3의 발현에 영향을 미치지 않는다. 넉인된 뉴클레오티드 서열은 정지 코돈 대신 삽입되고 넉인 공여체 카세트는 삽입된 뉴클레오티드 서열의 N-말단에 적어도 하나의 2A 자가-절단 펩티드를 포함하여, C3 단백질로부터 삽입된 서열 단백질 발현 산물의 분리를 가능하게 한다.
또 다른 전략은 정지 코돈을 교체하여 특정 C3 대립유전자에 뉴클레오티드의 서열을 넉인하는 것이다. 이는 C3 대립유전자의 엑손 41에 위치한 rs17030과 같은, 정지 코돈의 상류 150개 뉴클레오티드 내에 위치한 SNP 위치로 CRISPR 뉴클레아제를 표적화하는 RNA 분자를 이용하는 것에 의해 달성될 수 있다.
C3 유전자의 대립유전자를 특이적으로
표적화하는
RNA 가이드 서열의 예
다수의 가이드 서열이 C3 대립유전자를 표적화하도록 설계될 수 있으나, 하기 서열번호 1 내지 7,046으로 식별되는 표 1에 기술된 뉴클레오티드 서열은 구체적으로, 본원에 기재된 방법을 효과적으로 구현하고, 대립유전자들을 효과적으로 구별하기 위해 선택되었다.
표 1은 C3 대립유전자와 회합하여 전술된 구체예에 기재된 바와 같이 사용하도록 설계된 가이드 서열을 보여준다. 각각의 조작된 가이드 분자는 또한 PAM(protospacer adjacent motif), 예를 들어, "N"는 임의의 핵염기인 것인 서열 NGG 또는 NAG와 일치하는 PAM 옆에 있는 목적 표적 게놈 DNA 서열과 회합하도록 설계된다. 가이드 서열은, 예를 들어 SpCas9WT(PAM SEQ: NGG), SpCas9.VQR.1(PAM SEQ: NGAN), SpCas9.VQR.2(PAM SEQ: NGNG), SpCas9.EQR(PAM SEQ: NGAG), SpCas9.VRER(PAM SEQ: NGCG), SaCas9WT(PAM SEQ: NNGRRT), SpRY(PAM SEQ: NRN 또는 NYN), NmCas9WT(PAM SEQ: NNNNGATT), Cpf1(PAM SEQ: TTTV) 또는 JeCas9WT(PAM SEQ: NNNVRYM)를 포함하나, 이에 한정되지 않는 하나 이상의 다른 CRISPR 뉴클레아제와 함께 작동하도록 설계되었다. 본 발명의 RNA 분자는 각각 하나 이상의 상이한 CRISPR 뉴클레아제와 함께 복합체를 형성하도록 설계되었고, 이용된 CRISPR 뉴클레아제 각각에 대해 하나 이상의 상이한 PAM 서열을 이용하여 목적 폴리뉴클레오티드 서열을 표적화하도록 설계되었다.
표 1: 특정한 C3 유전자 표적과 회합하도록 설계된 가이드 서열 부분
표 1의 컬럼 1에 열거된 표시된 위치는 gnomAD v3 데이터베이스 및 UCSC Genome Browser 어셈블리 ID: hg38, 시퀀싱/어셈블리 공급자 ID: Genome Reference Consortium Human GRCh38.p12(GCA_000001405.27)에 근거한다. 어셈블리 일자: 2013년 12월; 2017년 12월 patch release 12.
SNP 세부정보는 열거된 SNP ID 번호 ("rs 번호")로 표시되며, 이는 NCBI 2018 dbSNP(database of Single Nucleotide Polymorphi는)에 근거한다. 표시된 DNA 돌연변이는 NCBI RefSeq 유전자로부터 수득된 Transcript Consequence NM_001256054와 관련된다.
본 발명의 보다 완전한 이해를 촉진하기 위해 실시예가 하기에 제공된다. 하기 실시예는 본 발명의 제조 및 실시의 예시적 방식을 예시한다. 그러나, 본 발명의 범주는 이들 실시예에 개시된 특정 구체예에 제한되지 않으며, 이는 단지 예시 목적을 위한 것이다.
도 1: HeLa 세포에서 C3 유전자의 인트론 1을 표적으로 하는 RNA 가이드 분자의 편집 활성. DNA 형질감염 72시간 후에 세포를 수집하고, 게놈 DNA를 추출하고, 표적 영역을 증폭시키고, 차세대 염기서열 분석(NGS)을 통해 돌연변이를 분석했다. 그래프는 3회의 독립적인 형질감염의 편집 % ± 표준 편차를 나타낸다.
도 2: 각각 C3 유전자의 인트론 1을 표적으로 하는 "g6" 및 "g11" 가이드 분자의 활성. OMNI-79 가이드를 HeLa 세포에 형질감염시켰다. OMNI-50 단백질과 OMNI-50 합성 RNA 가이드 분자를 포함하는 RNP를 HepG2 세포에 전기천공했다. DNA 형질감염 72시간 후 세포를 수집하고, 게놈 DNA를 추출하고, 표적 영역을 증폭시키고 차세대 염기서열 분석(NGS)을 통해 돌연변이를 분석했다. 그래프는 3회의 독립적인 형질감염 또는 2회의 독립적인 RNP 전기천공의 편집 % ± 표준 편차를 나타낸다.
도 3: 대조군 시료 대비 편집된 시료의 C3 mRNA의 상대적 양. 전기천공 후 7일차에 세포를 수집했다. 그 후, RNA를 추출하고 RT-qPCR을 위해 처리했다. 그래프는 2회의 독립적인 RNP 전기천공의 대조군 시료 대비 편집된 시료의 C3 mRNA의 상대적 양 ± 표준 편차를 나타낸다.
도 4: 상동성 기반 복구(HDR)에 의한 C3 내인성 유전자좌로의 GFP 삽입. 엑손 1은 분비되기 전에 절단되는 신호 펩티드를 코딩한다. GFP는 분비될 엑손 1 신호 펩티드와 함께 스플라이싱된다. 개략도에서 "좌측 HA" 및 "우측 HA"는 각각 왼쪽 및 오른쪽 상동성 암(homologous arm)을 나타내고, "SA"는 스플라이스 수용체 부위(splice acceptor site)를 나타내며, "PolyA"는 폴리아데닐화 신호를 나타낸다.
도 5: 유세포 분석법으로 측정한 감염 후 72시간의 GFP 발현. HepG2 세포를 CRISPR 뉴클레아제(OMNI-79 V5570)와 가이드(C3 g11) 또는 GFP 상동성 기반 복구(HDR) 주형을 포함하는, 표시된 AAV 바이러스 입자로 감염시켰다. 구성적 프로모터 하에 GFP를 코딩하는 DNA 분자를 포함하는 AAV를 감염 효율 평가를 위한 양성 대조군으로 사용했다. HDR 주형으로만 감염된 세포에서는 GFP 발현이 검출되지 않았고, 이는 오프타겟 통합(off-target integration)이 없다는 것을 나타낸다. 그래프는 % GFP 양성 세포의 평균 ± 표준 편차(n=3)를 나타낸다.
도 6: 유세포 분석법으로 측정한 감염 후 15일차 HepG2 세포의 GFP 발현. 특히, GFP 양성 세포 집단이 빈도가 증가했다.
도 7: 치료 후 15일차 HepG2 세포에서 GFP 분비의 플레이트 리더 측정. 감염 후 14일차에, 세포 배지를 Opti-MEM®으로 교체하여 자가형광(autofluorescence)을 감소시켰고, 15일차에 세포 배지를 수집하여 GFP 형광을 측정했다. 모든 HDR 양성 조건에서, GFP 형광은 미처리(non-treated: NT) 세포의 백그라운드보다 높았다.
도 8: 처리 후 8일차에 GFP 발현의 유세포 분석법에 의한 검출로 측정된 전기천공 후 편집 후 GFP 통합. HepG2 세포를 OMNI-50 뉴클레아제 및 가이드(C3 g11)를 포함하는 RNP로 전기천공하고, 전기천공 2시간 후 GFP HDR 주형을 포함하는 AAV로 감염시켰다. 구성적 프로모터 하에 GFP를 코딩하는 DNA 분자를 포함하는 AAV를 감염 효율 평가를 위한 양성 대조군으로 사용했다. GFP는 RNP로 전기천공되고 HDR 주형으로 감염된 세포에서 검출되었다. 그래프는 % GFP 양성 세포의 평균 ± 표준 편차(n=2)를 나타낸다.
도 9: 치료 후 8일차 HepG2 세포에서 GFP 분비의 플레이트 리더 측정. 감염 후 7일차에, 세포 배지를 Opti-MEM®으로 교체하여 자가형광을 감소시키고, 8일차에 세포 배지를 수집하여 GFP 형광을 측정했다. 미처리(NT) 시료의 비특이적 형광을 모든 시료로부터 샘플에서 뺐다.
도 2: 각각 C3 유전자의 인트론 1을 표적으로 하는 "g6" 및 "g11" 가이드 분자의 활성. OMNI-79 가이드를 HeLa 세포에 형질감염시켰다. OMNI-50 단백질과 OMNI-50 합성 RNA 가이드 분자를 포함하는 RNP를 HepG2 세포에 전기천공했다. DNA 형질감염 72시간 후 세포를 수집하고, 게놈 DNA를 추출하고, 표적 영역을 증폭시키고 차세대 염기서열 분석(NGS)을 통해 돌연변이를 분석했다. 그래프는 3회의 독립적인 형질감염 또는 2회의 독립적인 RNP 전기천공의 편집 % ± 표준 편차를 나타낸다.
도 3: 대조군 시료 대비 편집된 시료의 C3 mRNA의 상대적 양. 전기천공 후 7일차에 세포를 수집했다. 그 후, RNA를 추출하고 RT-qPCR을 위해 처리했다. 그래프는 2회의 독립적인 RNP 전기천공의 대조군 시료 대비 편집된 시료의 C3 mRNA의 상대적 양 ± 표준 편차를 나타낸다.
도 4: 상동성 기반 복구(HDR)에 의한 C3 내인성 유전자좌로의 GFP 삽입. 엑손 1은 분비되기 전에 절단되는 신호 펩티드를 코딩한다. GFP는 분비될 엑손 1 신호 펩티드와 함께 스플라이싱된다. 개략도에서 "좌측 HA" 및 "우측 HA"는 각각 왼쪽 및 오른쪽 상동성 암(homologous arm)을 나타내고, "SA"는 스플라이스 수용체 부위(splice acceptor site)를 나타내며, "PolyA"는 폴리아데닐화 신호를 나타낸다.
도 5: 유세포 분석법으로 측정한 감염 후 72시간의 GFP 발현. HepG2 세포를 CRISPR 뉴클레아제(OMNI-79 V5570)와 가이드(C3 g11) 또는 GFP 상동성 기반 복구(HDR) 주형을 포함하는, 표시된 AAV 바이러스 입자로 감염시켰다. 구성적 프로모터 하에 GFP를 코딩하는 DNA 분자를 포함하는 AAV를 감염 효율 평가를 위한 양성 대조군으로 사용했다. HDR 주형으로만 감염된 세포에서는 GFP 발현이 검출되지 않았고, 이는 오프타겟 통합(off-target integration)이 없다는 것을 나타낸다. 그래프는 % GFP 양성 세포의 평균 ± 표준 편차(n=3)를 나타낸다.
도 6: 유세포 분석법으로 측정한 감염 후 15일차 HepG2 세포의 GFP 발현. 특히, GFP 양성 세포 집단이 빈도가 증가했다.
도 7: 치료 후 15일차 HepG2 세포에서 GFP 분비의 플레이트 리더 측정. 감염 후 14일차에, 세포 배지를 Opti-MEM®으로 교체하여 자가형광(autofluorescence)을 감소시켰고, 15일차에 세포 배지를 수집하여 GFP 형광을 측정했다. 모든 HDR 양성 조건에서, GFP 형광은 미처리(non-treated: NT) 세포의 백그라운드보다 높았다.
도 8: 처리 후 8일차에 GFP 발현의 유세포 분석법에 의한 검출로 측정된 전기천공 후 편집 후 GFP 통합. HepG2 세포를 OMNI-50 뉴클레아제 및 가이드(C3 g11)를 포함하는 RNP로 전기천공하고, 전기천공 2시간 후 GFP HDR 주형을 포함하는 AAV로 감염시켰다. 구성적 프로모터 하에 GFP를 코딩하는 DNA 분자를 포함하는 AAV를 감염 효율 평가를 위한 양성 대조군으로 사용했다. GFP는 RNP로 전기천공되고 HDR 주형으로 감염된 세포에서 검출되었다. 그래프는 % GFP 양성 세포의 평균 ± 표준 편차(n=2)를 나타낸다.
도 9: 치료 후 8일차 HepG2 세포에서 GFP 분비의 플레이트 리더 측정. 감염 후 7일차에, 세포 배지를 Opti-MEM®으로 교체하여 자가형광을 감소시키고, 8일차에 세포 배지를 수집하여 GFP 형광을 측정했다. 미처리(NT) 시료의 비특이적 형광을 모든 시료로부터 샘플에서 뺐다.
실험적 세부사항
실시예
1: C3 온타겟 활성 분석
서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17-50개의 연속 뉴클레오티드를 포함하는 가이드 서열을 HeLa 세포에서 SpCas9를 사용하여 높은 온타켓 활성에 대해 스크리닝한다. 온타겟 활성은 DNA 모세관 전기영동 분석에 의해 결정한다.
실시예 2: C3-표적화 RNA 가이드 분자의 활성
C3 유전자는 표적 조직에서의 풍부한 발현과 분비를 보장하고 C3 발현을 보존하는 방식으로 새로운 서열의 통합을 수용할 수 있는 능력으로 인해 간 세포에서 표적화할 게놈 세이프 하버 부위로 선택되었다. 삽입 부위는 C3의 첫 번째 엑손에서 코딩되고, 궁극적으로 최종 단백질 산물로부터 절단되는 분비성 펩티드에 근접한 C3의 첫 번째 인트론 내로 조작되었다. OMNI-50 및 OMNI-79 CRISPR 뉴클레아제를 사용한 가이드 스크린을 HeLa 세포에서 수행하였다. 간략하게, OMNI-50 또는 OMNI-79 뉴클레아제 코딩 플라스미드(64ng)를 jetOPTIMUS 시약(Polyplus)을 사용하여 96 웰 플레이트 포맷에서 각 가이드-코딩 DNA 플라스미드(20ng)와 공동 형질감염시켰다. DNA 형질감염 72시간 후 세포를 수집하고 게놈 DNA를 추출하고, 차세대 시퀀싱(NGS) 분석에 사용했다. 도 1의 그래프는 3개의 독립적인 실험의 % 편집의 평균 ± 표준 편차(STDV)을 나타낸다. NGS 분석은 두 뉴클레아제에 대해 8% 내지 86% 범위의 편집을 보여준다. 특히, OMNI-50 RNP 조성물은 일반적으로 DNA-기반 조성물에 비해 증가된 활성을 나타내므로, HeLa 세포의 DNA 스크리닝은 개념 증명(proof of concept)을 위한 더 낮은 컷오프를 갖는다.
CRISPR 뉴클레아제와 HDR 주형은 AAV(아데노-연관 바이러스)에 의해 표적 세포에 전달될 수 있다. OMNI-79 뉴클레아제는 크기가 작기 때문에, 가이드 분자와 함께 AAV에 패키징될 수 있다. HeLa 세포에서의 활성을 테스트하기 위해, 가이드 "g6" 및 "g11"을 OMNI-79 V5570 뉴클레아제와 함께 AAV 벡터에 클로닝했다(도 2). 간략하게, AAV 플라스미드(150ng)를 jetOPTIMUS 시약(Polyplus)을 사용하여 96 웰 플레이트 포맷에서 형질감염시켰다. 형질감염 72시간 후 게놈 DNA를 추출하고 NGS로 분석했다. 도 2의 그래프는 3개의 독립적인 실험의 % 편집의 평균 ± STDV를 나타낸다.
OMNI-50 가이드 "g6" 및 "g11"의 활성은 RNP 전기천공을 통해 HepG2 세포에서 평가하였다. 간략하게, 4 x 105 HepG2 세포를 105 pmole OMNI-50 단백질과 120 pmole sgRNA로 구성된 미리 조립된 RNP와 혼합하고, 그 후, 100 pmole의 전기천공 강화제(electroporation enhancer)(IDT-1075916)와 혼합했다. 그 후, DS-123 프로그램을 적용하여 SF Cell 4D-Nucleofector X Kit S(PBC2-00675, Lonza)를 사용하여 이 혼합물을 세포에 전기천공했다. 전기천공 후 72시간 후에 세포의 일부를 수집하고 게놈 DNA를 추출하여 NGS에 의한 온타겟 활성을 측정했다. NGS 분석에 따르면, 두 가이드 모두 높은 인델(indel) 형성 활성을 보였다(도 2).
C3 발현에 대한 OMNI-50 가이드 조성물 편집의 효과를 평가하기 위해, 전기천공 후 7일차에 HepG2 세포로부터 총 RNA를 추출하고 C3의 mRNA 수준을 qRT-PCR로 측정했다. 결과는 C3 mRNA 수준에 대한 미미한 효과만이 검출되었기 때문에, C3의 보존된 발현을 입증했다(도 3).
C3 유전자좌에서 HDR의 타당성(feasibility)을 검증하기 위해, 500개 뉴클레오티드(서열번호 7054), 800개 뉴클레오티드(서열번호 7053) 및 927개 뉴클레오티드(서열번호 7052)의 상동성 암 길이를 갖는 3개의 구조체를 클로닝했다. 상동성 암은 "g11" 가이드 분자의 절단 부위(cut site)에 배치되었다. 폴리-A 테일을 갖는 GFP를 코딩하는 서열을 HDR 주형의 리포터 유전자로 사용했다. 길이가 32개 뉴클레오티드인 스플라이스 수용체 부위를 GFP 서열의 상류에 추가했다(도 4). 이 경우, 다른 스플라이스 서열을 사용할 수도 있지만, 스플라이스 부위 서열은 pmaxGFP 벡터(Lonza)로부터 가져왔다. 이 특정 HDR 주형 삽입은 poc(proof of concept)으로 사용되었으며 C3 내인성 단백질 발현을 방해한다. "정지(STOP)" 코돈의 사용을 피하고 C3 단백질 발현을 허용하기 위해, P2A 펩티드 서열을 갖는 다른 공여체 주형을 설계할 수 있다.
OMNI-79 V5570 뉴클레아제 및 C3 표적화 "g11" 가이드 분자, 또는 GFP HDR 주형을 AAV DJ 바이러스 입자에 패키징했다. HepG2 세포를 105의 감염 다중도(MOI)로 표시된 AAV 입자 각각으로 감염시켰다. 처리 후 72시간차 및 15일차에 GFP 발현에 대해 유세포 분석법으로 세포를 분석했다(도 5 및 도 6). GFP 분비는 플레이트 판독기로 평가하였다(도 7). 편집 수준은 DNA 추출 후 NGS를 통해 72시간 후에 분석했다. 뉴클레아제와 가이드 분자만으로 감염된 세포는 42.24 ± 4.4%의 편집을 보였다. 편집 수준과 HDR 비율 간에 HDR이 매우 효율적이라는 보여주는 상관관계가 있다.
GFP 형광은 세포 배지에서도 검출되었으며(도 7), 이는 HDR 주형의 올바른 통합 및 스플라이싱을 나타낸다.
유사한 HDR 수준은 또한, 전기천공 및 HDR 주형의 AAV 전달을 이용한, OMNI-50 뉴클레아제 및 C3 표적화 "g11" 가이드에 의한 RNP 편집에서도 입증되었다(도 8, 도 9). 편집 수준은 RNP만 처리된 세포에서 53.6 ± 1.05%였다.
표 2: C3의 인트론 1을 표적으로 하는 22-뉴클레오티드 가이드 서열 부분.
| 가이드 명칭 | 서열 | PAM |
| g2 | GGGUUUAAAGAUUGGCUACUUC (서열번호 6417) | GGG |
| g3 | UACUUCGGGUUCAUGUAUAGUU(서열번호 6617) | UGG |
| g4 | ACUUCGGGUUCAUGUAUAGUUG (서열번호 5403) | GGG |
| g6 | AGGUUUUGGCGUAUGUGGGUUU(서열번호 5493) | GGG |
| g7 | UUUGGCGUAUGUGGGUUUGGGU(서열번호 7030) | AGG |
| g8 | UGGGUUUGGGUAGGUAGAGUUG (서열번호 6873) | AGG |
| g9 | GGGUUUGGGUAGGAGAGUUGA(서열번호 6421) | GGG |
| g10 | GGUAGGUAGAGUUGAGGGGUUC(서열번호 6425) | CGG |
| g11 | GUAGGAGAGUUGAGGGGUGUCC(서열번호 6473) | GGG |
| g13 | GCCAGGCCCAGCUGGCUGAGAG(서열번호 6240) | UGG |
| g15 | AGCUGGCUGAGAGUGGGAGUCA(서열번호 5453) | UGG |
| g23 | GAGGUUUGGACUUUACAAGAUU(서열번호 6176) | UGG |
| g24 | AGGUUUGGACUUUACAAGAUUU(서열번호 5492) | GGG |
| g28 | GUAUUUAUUAGGACUGGGGUGU(서열번호 6481) | UGG |
표 3: OMNI CRISPR 뉴클레아제 서열, PAM 요건, 및 sgRNA 스캐폴드 서열
| OMNI CRISPR 뉴클레아제 및 gRNA | PAM 서열 | sgRNA 스캐폴드 서열 |
| OMNI-79 (서열번호 7055) |
NGR | GUUGCCGCUGGAGAAAUCCAGUUGUUAACAAGCAGCUUGACUGCACCAAAUAAGGCGGGGGGCUGCGGCCCUCGCUUUUUU (서열번호 7058) |
| OMNI-79 V5570 (서열번호 7056) |
NGR | GUUGCCGCUGGAGAAAUCCAGUUGUUAACAAGCAGCUUGACUGCACCAAAUAAGGCGGGGGGCUGCGGCCCUCGCUUUUUU (서열번호 7058) |
| OMNI-50 (서열번호 7057) |
NGG | GUUUGAGAGUUAUGUAAGAAAUUACAUGACGAGUUCAAAUAAAAAUUUAUUCAAACCGCCUAUUUAUAGGCCGCAGAUGUUCUGCAUUAUGCUUGCUAUUGCAAGCUUUUUU (서열번호 7059) |
OMNI-79 CRISPR 뉴클레아제 및 OMNI-50 CRISPR 뉴클레아제는 각각의 내용이 참조에 의해 본원에 포함된, PCT 국제 출원 공개 WO/2021/248016 및 WO/2020/223513을 참조한다.
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<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 26
gcauucgucc uccucgggcc 20
<210> 27
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 27
gcccgaggag gacgaaugcc 20
<210> 28
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 28
ggacacuugg guggagcacu 20
<210> 29
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 29
ggagcacugg cccgaggagg 20
<210> 30
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 30
ggcauucguc cuccucgggc 20
<210> 31
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 31
ggcccgagga ggacgaaugc 20
<210> 32
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 32
ggguggagca cuggcccgag 20
<210> 33
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 33
gguggagcac uggcccgagg 20
<210> 34
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 34
guccuccucg ggccagugcu 20
<210> 35
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 35
gucuuggcau ucguccuccu 20
<210> 36
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 36
guggagcacu ggcccgagga 20
<210> 37
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 37
uccuccucgg gccagugcuc 20
<210> 38
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 38
uccucgggcc agugcuccac 20
<210> 39
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 39
ucgggccagu gcuccaccca 20
<210> 40
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 40
ucguccuccu cgggccagug 20
<210> 41
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 41
ucgucuuggc auucguccuc 20
<210> 42
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 42
uggagcacug gcccgaggag 20
<210> 43
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 43
uggcauucgu ccuccucggg 20
<210> 44
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 44
uggcccgagg aggacgaaug 20
<210> 45
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 45
uggguggagc acuggcccga 20
<210> 46
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 46
uucguccucc ucgggccagu 20
<210> 47
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 47
uucgucuugg cauucguccu 20
<210> 48
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 48
uuggcauucg uccuccucgg 20
<210> 49
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 49
uuggguggag cacuggcccg 20
<210> 50
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 50
aaggacacuu ggguggagca c 21
<210> 51
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 51
acacuugggu ggagcacugg c 21
<210> 52
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 52
acuggcccga ggaggacgaa u 21
<210> 53
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 53
acuugggugg agcacuggcc c 21
<210> 54
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 54
agcacuggcc cgaggaggac g 21
<210> 55
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 55
aggacacuug gguggagcac u 21
<210> 56
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 56
auucguccuc cucgggccag u 21
<210> 57
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 57
cacuggcccg aggaggacga a 21
<210> 58
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 58
cacuugggug gagcacuggc c 21
<210> 59
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 59
cauucguccu ccucgggcca g 21
<210> 60
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 60
cccgaggagg acgaaugcca a 21
<210> 61
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 61
ccgaggagga cgaaugccaa g 21
<210> 62
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 62
ccuccucggg ccagugcucc a 21
<210> 63
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 63
ccucgggcca gugcuccacc c 21
<210> 64
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 64
cgggccagug cuccacccaa g 21
<210> 65
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 65
cguccuccuc gggccagugc u 21
<210> 66
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 66
cgucuuggca uucguccucc u 21
<210> 67
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 67
cuccucgggc cagugcucca c 21
<210> 68
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 68
cucgggccag ugcuccaccc a 21
<210> 69
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 69
cuggcccgag gaggacgaau g 21
<210> 70
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 70
cuucgucuug gcauucgucc u 21
<210> 71
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 71
cuuggcauuc guccuccucg g 21
<210> 72
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 72
cuugggugga gcacuggccc g 21
<210> 73
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 73
gacacuuggg uggagcacug g 21
<210> 74
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 74
gagcacuggc ccgaggagga c 21
<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 75
gcacuggccc gaggaggacg a 21
<210> 76
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 76
gcauucgucc uccucgggcc a 21
<210> 77
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 77
gcccgaggag gacgaaugcc a 21
<210> 78
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 78
ggacacuugg guggagcacu g 21
<210> 79
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 79
ggagcacugg cccgaggagg a 21
<210> 80
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 80
ggcauucguc cuccucgggc c 21
<210> 81
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 81
ggcccgagga ggacgaaugc c 21
<210> 82
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 82
ggguggagca cuggcccgag g 21
<210> 83
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 83
gguggagcac uggcccgagg a 21
<210> 84
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 84
guccuccucg ggccagugcu c 21
<210> 85
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 85
gucuuggcau ucguccuccu c 21
<210> 86
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 86
guggagcacu ggcccgagga g 21
<210> 87
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 87
uccuccucgg gccagugcuc c 21
<210> 88
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 88
uccucgggcc agugcuccac c 21
<210> 89
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 89
ucgggccagu gcuccaccca a 21
<210> 90
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 90
ucguccuccu cgggccagug c 21
<210> 91
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 91
ucgucuuggc auucguccuc c 21
<210> 92
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 92
ucuucgucuu ggcauucguc c 21
<210> 93
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 93
ucuuggcauu cguccuccuc g 21
<210> 94
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 94
uggagcacug gcccgaggag g 21
<210> 95
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 95
uggcauucgu ccuccucggg c 21
<210> 96
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 96
uggcccgagg aggacgaaug c 21
<210> 97
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 97
uggguggagc acuggcccga g 21
<210> 98
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 98
uucguccucc ucgggccagu g 21
<210> 99
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 99
uucgucuugg cauucguccu c 21
<210> 100
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 100
uuggcauucg uccuccucgg g 21
<210> 101
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 101
uuggguggag cacuggcccg a 21
<210> 102
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 102
aaggacacuu ggguggagca cu 22
<210> 103
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 103
acacuugggu ggagcacugg cc 22
<210> 104
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 104
acuggcccga ggaggacgaa ug 22
<210> 105
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 105
acuugggugg agcacuggcc cg 22
<210> 106
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 106
agcacuggcc cgaggaggac ga 22
<210> 107
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 107
aggacacuug gguggagcac ug 22
<210> 108
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 108
auucguccuc cucgggccag ug 22
<210> 109
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 109
cacuggcccg aggaggacga au 22
<210> 110
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 110
cacuugggug gagcacuggc cc 22
<210> 111
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 111
cauucguccu ccucgggcca gu 22
<210> 112
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 112
cccgaggagg acgaaugcca ag 22
<210> 113
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 113
ccgaggagga cgaaugccaa ga 22
<210> 114
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 114
ccuccucggg ccagugcucc ac 22
<210> 115
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 115
ccucgggcca gugcuccacc ca 22
<210> 116
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 116
cgggccagug cuccacccaa gu 22
<210> 117
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 117
cguccuccuc gggccagugc uc 22
<210> 118
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 118
cgucuuggca uucguccucc uc 22
<210> 119
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 119
cuccucgggc cagugcucca cc 22
<210> 120
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 120
cucgggccag ugcuccaccc aa 22
<210> 121
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 121
cucuucgucu uggcauucgu cc 22
<210> 122
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 122
cuggcccgag gaggacgaau gc 22
<210> 123
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 123
cuucgucuug gcauucgucc uc 22
<210> 124
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 124
cuuggcauuc guccuccucg gg 22
<210> 125
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 125
cuugggugga gcacuggccc ga 22
<210> 126
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 126
gaaggacacu uggguggagc ac 22
<210> 127
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 127
gacacuuggg uggagcacug gc 22
<210> 128
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 128
gagcacuggc ccgaggagga cg 22
<210> 129
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 129
gcacuggccc gaggaggacg aa 22
<210> 130
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 130
gcauucgucc uccucgggcc ag 22
<210> 131
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 131
gcccgaggag gacgaaugcc aa 22
<210> 132
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 132
ggacacuugg guggagcacu gg 22
<210> 133
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 133
ggagcacugg cccgaggagg ac 22
<210> 134
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 134
ggcauucguc cuccucgggc ca 22
<210> 135
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 135
ggcccgagga ggacgaaugc ca 22
<210> 136
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 136
ggguggagca cuggcccgag ga 22
<210> 137
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 137
gguggagcac uggcccgagg ag 22
<210> 138
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 138
guccuccucg ggccagugcu cc 22
<210> 139
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 139
gucuuggcau ucguccuccu cg 22
<210> 140
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 140
guggagcacu ggcccgagga gg 22
<210> 141
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 141
uccuccucgg gccagugcuc ca 22
<210> 142
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 142
uccucgggcc agugcuccac cc 22
<210> 143
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 143
ucgggccagu gcuccaccca ag 22
<210> 144
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 144
ucguccuccu cgggccagug cu 22
<210> 145
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 145
ucgucuuggc auucguccuc cu 22
<210> 146
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 146
ucuucgucuu ggcauucguc cu 22
<210> 147
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 147
ucuuggcauu cguccuccuc gg 22
<210> 148
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 148
uggagcacug gcccgaggag ga 22
<210> 149
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 149
uggcauucgu ccuccucggg cc 22
<210> 150
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 150
uggcccgagg aggacgaaug cc 22
<210> 151
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 151
uggguggagc acuggcccga gg 22
<210> 152
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 152
uucguccucc ucgggccagu gc 22
<210> 153
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 153
uucgucuugg cauucguccu cc 22
<210> 154
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 154
uuggcauucg uccuccucgg gc 22
<210> 155
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 155
uuggguggag cacuggcccg ag 22
<210> 156
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 156
acuggccuga ggaggacgaa 20
<210> 157
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 157
agcacuggcc ugaggaggac 20
<210> 158
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 158
auucguccuc cucaggccag 20
<210> 159
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 159
cacuggccug aggaggacga 20
<210> 160
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 160
caggccagug cuccacccaa 20
<210> 161
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 161
cauucguccu ccucaggcca 20
<210> 162
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 162
ccucaggcca gugcuccacc 20
<210> 163
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 163
ccuccucagg ccagugcucc 20
<210> 164
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 164
ccugaggagg acgaaugcca 20
<210> 165
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 165
cguccuccuc aggccagugc 20
<210> 166
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 166
cucaggccag ugcuccaccc 20
<210> 167
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 167
cuccucaggc cagugcucca 20
<210> 168
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 168
cugaggagga cgaaugccaa 20
<210> 169
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 169
cuggccugag gaggacgaau 20
<210> 170
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 170
cuuggcauuc guccuccuca 20
<210> 171
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 171
cuugggugga gcacuggccu 20
<210> 172
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 172
gagcacuggc cugaggagga 20
<210> 173
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 173
gcacuggccu gaggaggacg 20
<210> 174
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 174
gcauucgucc uccucaggcc 20
<210> 175
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 175
gccugaggag gacgaaugcc 20
<210> 176
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 176
ggagcacugg ccugaggagg 20
<210> 177
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 177
ggcauucguc cuccucaggc 20
<210> 178
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 178
ggccugagga ggacgaaugc 20
<210> 179
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 179
ggguggagca cuggccugag 20
<210> 180
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 180
gguggagcac uggccugagg 20
<210> 181
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 181
guccuccuca ggccagugcu 20
<210> 182
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 182
guggagcacu ggccugagga 20
<210> 183
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 183
uccucaggcc agugcuccac 20
<210> 184
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 184
uccuccucag gccagugcuc 20
<210> 185
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 185
ucguccuccu caggccagug 20
<210> 186
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 186
uggagcacug gccugaggag 20
<210> 187
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 187
uggcauucgu ccuccucagg 20
<210> 188
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 188
uggccugagg aggacgaaug 20
<210> 189
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 189
uggguggagc acuggccuga 20
<210> 190
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 190
uucguccucc ucaggccagu 20
<210> 191
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 191
uuggcauucg uccuccucag 20
<210> 192
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 192
uuggguggag cacuggccug 20
<210> 193
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 193
acuggccuga ggaggacgaa u 21
<210> 194
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 194
acuugggugg agcacuggcc u 21
<210> 195
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 195
agcacuggcc ugaggaggac g 21
<210> 196
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 196
auucguccuc cucaggccag u 21
<210> 197
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 197
cacuggccug aggaggacga a 21
<210> 198
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 198
caggccagug cuccacccaa g 21
<210> 199
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 199
cauucguccu ccucaggcca g 21
<210> 200
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 200
ccucaggcca gugcuccacc c 21
<210> 201
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 201
ccuccucagg ccagugcucc a 21
<210> 202
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 202
ccugaggagg acgaaugcca a 21
<210> 203
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 203
cguccuccuc aggccagugc u 21
<210> 204
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 204
cucaggccag ugcuccaccc a 21
<210> 205
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 205
cuccucaggc cagugcucca c 21
<210> 206
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 206
cugaggagga cgaaugccaa g 21
<210> 207
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 207
cuggccugag gaggacgaau g 21
<210> 208
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 208
cuuggcauuc guccuccuca g 21
<210> 209
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 209
cuugggugga gcacuggccu g 21
<210> 210
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 210
gagcacuggc cugaggagga c 21
<210> 211
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 211
gcacuggccu gaggaggacg a 21
<210> 212
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 212
gcauucgucc uccucaggcc a 21
<210> 213
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 213
gccugaggag gacgaaugcc a 21
<210> 214
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 214
ggagcacugg ccugaggagg a 21
<210> 215
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 215
ggcauucguc cuccucaggc c 21
<210> 216
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 216
ggccugagga ggacgaaugc c 21
<210> 217
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 217
ggguggagca cuggccugag g 21
<210> 218
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 218
gguggagcac uggccugagg a 21
<210> 219
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 219
guccuccuca ggccagugcu c 21
<210> 220
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 220
guggagcacu ggccugagga g 21
<210> 221
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 221
ucaggccagu gcuccaccca a 21
<210> 222
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 222
uccucaggcc agugcuccac c 21
<210> 223
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 223
uccuccucag gccagugcuc c 21
<210> 224
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 224
ucguccuccu caggccagug c 21
<210> 225
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 225
ucuuggcauu cguccuccuc a 21
<210> 226
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 226
uggagcacug gccugaggag g 21
<210> 227
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 227
uggcauucgu ccuccucagg c 21
<210> 228
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 228
uggccugagg aggacgaaug c 21
<210> 229
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 229
uggguggagc acuggccuga g 21
<210> 230
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 230
uucguccucc ucaggccagu g 21
<210> 231
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 231
uuggcauucg uccuccucag g 21
<210> 232
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 232
uuggguggag cacuggccug a 21
<210> 233
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 233
acuggccuga ggaggacgaa ug 22
<210> 234
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 234
acuugggugg agcacuggcc ug 22
<210> 235
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 235
agcacuggcc ugaggaggac ga 22
<210> 236
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 236
auucguccuc cucaggccag ug 22
<210> 237
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 237
cacuggccug aggaggacga au 22
<210> 238
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 238
cacuugggug gagcacuggc cu 22
<210> 239
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 239
caggccagug cuccacccaa gu 22
<210> 240
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 240
cauucguccu ccucaggcca gu 22
<210> 241
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 241
ccucaggcca gugcuccacc ca 22
<210> 242
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 242
ccuccucagg ccagugcucc ac 22
<210> 243
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 243
ccugaggagg acgaaugcca ag 22
<210> 244
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 244
cguccuccuc aggccagugc uc 22
<210> 245
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 245
cucaggccag ugcuccaccc aa 22
<210> 246
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 246
cuccucaggc cagugcucca cc 22
<210> 247
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 247
cugaggagga cgaaugccaa ga 22
<210> 248
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 248
cuggccugag gaggacgaau gc 22
<210> 249
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 249
cuuggcauuc guccuccuca gg 22
<210> 250
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 250
cuugggugga gcacuggccu ga 22
<210> 251
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 251
gagcacuggc cugaggagga cg 22
<210> 252
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 252
gcacuggccu gaggaggacg aa 22
<210> 253
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 253
gcauucgucc uccucaggcc ag 22
<210> 254
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 254
gccugaggag gacgaaugcc aa 22
<210> 255
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 255
ggagcacugg ccugaggagg ac 22
<210> 256
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 256
ggcauucguc cuccucaggc ca 22
<210> 257
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 257
ggccugagga ggacgaaugc ca 22
<210> 258
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 258
ggguggagca cuggccugag ga 22
<210> 259
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 259
gguggagcac uggccugagg ag 22
<210> 260
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 260
guccuccuca ggccagugcu cc 22
<210> 261
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 261
gucuuggcau ucguccuccu ca 22
<210> 262
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 262
guggagcacu ggccugagga gg 22
<210> 263
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 263
ucaggccagu gcuccaccca ag 22
<210> 264
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 264
uccucaggcc agugcuccac cc 22
<210> 265
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 265
uccuccucag gccagugcuc ca 22
<210> 266
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 266
ucguccuccu caggccagug cu 22
<210> 267
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 267
ucuuggcauu cguccuccuc ag 22
<210> 268
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 268
uggagcacug gccugaggag ga 22
<210> 269
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 269
uggcauucgu ccuccucagg cc 22
<210> 270
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 270
uggccugagg aggacgaaug cc 22
<210> 271
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 271
uggguggagc acuggccuga gg 22
<210> 272
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 272
uucguccucc ucaggccagu gc 22
<210> 273
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 273
uuggcauucg uccuccucag gc 22
<210> 274
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 274
uuggguggag cacuggccug ag 22
<210> 275
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 275
aaacaccccc aaccgcacca 20
<210> 276
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 276
aaaccuccga gucuccaaac 20
<210> 277
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 277
aaaguccaaa ccuccgaguc 20
<210> 278
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 278
aacaccccca accgcaccau 20
<210> 279
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 279
aaccuccgag ucuccaaaca 20
<210> 280
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 280
aaguccaaac cuccgagucu 20
<210> 281
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 281
accuccgagu cuccaaacac 20
<210> 282
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 282
aguccaaacc uccgagucuc 20
<210> 283
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 283
agucuccaaa cacccccaac 20
<210> 284
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 284
auggugcggu uggggguguu 20
<210> 285
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 285
auugauggug cgguuggggg 20
<210> 286
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 286
caaacacccc caaccgcacc 20
<210> 287
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 287
caaaccuccg agucuccaaa 20
<210> 288
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 288
cauugauggu gcgguugggg 20
<210> 289
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 289
ccaaacaccc ccaaccgcac 20
<210> 290
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 290
ccaaaccucc gagucuccaa 20
<210> 291
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 291
ccgagucucc aaacaccccc 20
<210> 292
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 292
ccuccgaguc uccaaacacc 20
<210> 293
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 293
cgagucucca aacaccccca 20
<210> 294
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 294
cgguuggggg uguuuggaga 20
<210> 295
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 295
cuccaaacac ccccaaccgc 20
<210> 296
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 296
cuccgagucu ccaaacaccc 20
<210> 297
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 297
gagucuccaa acacccccaa 20
<210> 298
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 298
gauggugcgg uugggggugu 20
<210> 299
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 299
gcgguugggg guguuuggag 20
<210> 300
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 300
ggggguguuu ggagacucgg 20
<210> 301
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 301
gggguguuug gagacucgga 20
<210> 302
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 302
ggguguuugg agacucggag 20
<210> 303
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 303
ggugcgguug gggguguuug 20
<210> 304
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 304
gguguuugga gacucggagg 20
<210> 305
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 305
gguugggggu guuuggagac 20
<210> 306
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 306
guccaaaccu ccgagucucc 20
<210> 307
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 307
gucuccaaac acccccaacc 20
<210> 308
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 308
gugcgguugg ggguguuugg 20
<210> 309
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 309
guguuuggag acucggaggu 20
<210> 310
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 310
guugggggug uuuggagacu 20
<210> 311
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 311
guuuggagac ucggagguuu 20
<210> 312
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 312
ucauugaugg ugcgguuggg 20
<210> 313
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 313
uccaaacacc cccaaccgca 20
<210> 314
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 314
uccaaaccuc cgagucucca 20
<210> 315
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 315
uccgagucuc caaacacccc 20
<210> 316
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 316
ucuccaaaca cccccaaccg 20
<210> 317
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 317
ugauggugcg guugggggug 20
<210> 318
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 318
ugcgguuggg gguguuugga 20
<210> 319
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 319
uggggguguu uggagacucg 20
<210> 320
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 320
uggugcgguu ggggguguuu 20
<210> 321
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 321
uguuuggaga cucggagguu 20
<210> 322
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 322
uucauugaug gugcgguugg 20
<210> 323
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 323
uugauggugc gguugggggu 20
<210> 324
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 324
uugggggugu uuggagacuc 20
<210> 325
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 325
aaacaccccc aaccgcacca u 21
<210> 326
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 326
aaaccuccga gucuccaaac a 21
<210> 327
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 327
aaaguccaaa ccuccgaguc u 21
<210> 328
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 328
aacaccccca accgcaccau c 21
<210> 329
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 329
aaccuccgag ucuccaaaca c 21
<210> 330
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 330
aaguccaaac cuccgagucu c 21
<210> 331
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 331
accuccgagu cuccaaacac c 21
<210> 332
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 332
aguccaaacc uccgagucuc c 21
<210> 333
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 333
agucuccaaa cacccccaac c 21
<210> 334
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 334
auggugcggu uggggguguu u 21
<210> 335
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 335
auugauggug cgguuggggg u 21
<210> 336
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 336
caaacacccc caaccgcacc a 21
<210> 337
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 337
caaaccuccg agucuccaaa c 21
<210> 338
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 338
cauugauggu gcgguugggg g 21
<210> 339
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 339
ccaaacaccc ccaaccgcac c 21
<210> 340
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 340
ccaaaccucc gagucuccaa a 21
<210> 341
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 341
ccgagucucc aaacaccccc a 21
<210> 342
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 342
ccuccgaguc uccaaacacc c 21
<210> 343
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 343
cgagucucca aacaccccca a 21
<210> 344
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 344
cgguuggggg uguuuggaga c 21
<210> 345
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 345
cuccaaacac ccccaaccgc a 21
<210> 346
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 346
cuccgagucu ccaaacaccc c 21
<210> 347
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 347
gagucuccaa acacccccaa c 21
<210> 348
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 348
gauggugcgg uugggggugu u 21
<210> 349
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 349
gcgguugggg guguuuggag a 21
<210> 350
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 350
ggggguguuu ggagacucgg a 21
<210> 351
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 351
gggguguuug gagacucgga g 21
<210> 352
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 352
ggguguuugg agacucggag g 21
<210> 353
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 353
ggugcgguug gggguguuug g 21
<210> 354
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 354
gguguuugga gacucggagg u 21
<210> 355
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 355
gguugggggu guuuggagac u 21
<210> 356
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 356
guccaaaccu ccgagucucc a 21
<210> 357
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 357
gucuccaaac acccccaacc g 21
<210> 358
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 358
gugcgguugg ggguguuugg a 21
<210> 359
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 359
guguuuggag acucggaggu u 21
<210> 360
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 360
guucauugau ggugcgguug g 21
<210> 361
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 361
guugggggug uuuggagacu c 21
<210> 362
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 362
guuuggagac ucggagguuu g 21
<210> 363
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 363
uaaaguccaa accuccgagu c 21
<210> 364
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 364
ucauugaugg ugcgguuggg g 21
<210> 365
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 365
uccaaacacc cccaaccgca c 21
<210> 366
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 366
uccaaaccuc cgagucucca a 21
<210> 367
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 367
uccgagucuc caaacacccc c 21
<210> 368
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 368
ucuccaaaca cccccaaccg c 21
<210> 369
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 369
ugauggugcg guugggggug u 21
<210> 370
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 370
ugcgguuggg gguguuugga g 21
<210> 371
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 371
uggggguguu uggagacucg g 21
<210> 372
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 372
uggugcgguu ggggguguuu g 21
<210> 373
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 373
uguuuggaga cucggagguu u 21
<210> 374
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 374
uucauugaug gugcgguugg g 21
<210> 375
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 375
uugauggugc gguugggggu g 21
<210> 376
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 376
uugggggugu uuggagacuc g 21
<210> 377
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 377
aaacaccccc aaccgcacca uc 22
<210> 378
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 378
aaaccuccga gucuccaaac ac 22
<210> 379
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 379
aaaguccaaa ccuccgaguc uc 22
<210> 380
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 380
aacaccccca accgcaccau ca 22
<210> 381
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 381
aaccuccgag ucuccaaaca cc 22
<210> 382
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 382
aaguccaaac cuccgagucu cc 22
<210> 383
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 383
accuccgagu cuccaaacac cc 22
<210> 384
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 384
aguccaaacc uccgagucuc ca 22
<210> 385
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 385
agucuccaaa cacccccaac cg 22
<210> 386
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 386
auggugcggu uggggguguu ug 22
<210> 387
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 387
auugauggug cgguuggggg ug 22
<210> 388
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 388
caaacacccc caaccgcacc au 22
<210> 389
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 389
caaaccuccg agucuccaaa ca 22
<210> 390
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 390
cauugauggu gcgguugggg gu 22
<210> 391
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 391
ccaaacaccc ccaaccgcac ca 22
<210> 392
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 392
ccaaaccucc gagucuccaa ac 22
<210> 393
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 393
ccgagucucc aaacaccccc aa 22
<210> 394
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 394
ccuccgaguc uccaaacacc cc 22
<210> 395
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 395
cgagucucca aacaccccca ac 22
<210> 396
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 396
cgguuggggg uguuuggaga cu 22
<210> 397
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 397
cuccaaacac ccccaaccgc ac 22
<210> 398
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 398
cuccgagucu ccaaacaccc cc 22
<210> 399
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 399
gagucuccaa acacccccaa cc 22
<210> 400
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 400
gauggugcgg uugggggugu uu 22
<210> 401
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 401
gcgguugggg guguuuggag ac 22
<210> 402
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 402
ggggguguuu ggagacucgg ag 22
<210> 403
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 403
gggguguuug gagacucgga gg 22
<210> 404
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 404
ggguguuugg agacucggag gu 22
<210> 405
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 405
ggugcgguug gggguguuug ga 22
<210> 406
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 406
gguguuugga gacucggagg uu 22
<210> 407
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 407
gguugggggu guuuggagac uc 22
<210> 408
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 408
guaaagucca aaccuccgag uc 22
<210> 409
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 409
guccaaaccu ccgagucucc aa 22
<210> 410
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 410
gucuccaaac acccccaacc gc 22
<210> 411
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 411
gugcgguugg ggguguuugg ag 22
<210> 412
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 412
guguuuggag acucggaggu uu 22
<210> 413
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 413
guucauugau ggugcgguug gg 22
<210> 414
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 414
guugggggug uuuggagacu cg 22
<210> 415
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 415
guuuggagac ucggagguuu gg 22
<210> 416
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 416
uaaaguccaa accuccgagu cu 22
<210> 417
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 417
ucauugaugg ugcgguuggg gg 22
<210> 418
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 418
uccaaacacc cccaaccgca cc 22
<210> 419
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 419
uccaaaccuc cgagucucca aa 22
<210> 420
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 420
uccgagucuc caaacacccc ca 22
<210> 421
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 421
ucuccaaaca cccccaaccg ca 22
<210> 422
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 422
ugauggugcg guugggggug uu 22
<210> 423
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 423
ugcgguuggg gguguuugga ga 22
<210> 424
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 424
uggggguguu uggagacucg ga 22
<210> 425
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 425
uggugcgguu ggggguguuu gg 22
<210> 426
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 426
uguucauuga uggugcgguu gg 22
<210> 427
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 427
uguuuggaga cucggagguu ug 22
<210> 428
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 428
uucauugaug gugcgguugg gg 22
<210> 429
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 429
uugauggugc gguugggggu gu 22
<210> 430
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 430
uugggggugu uuggagacuc gg 22
<210> 431
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 431
aaaccuccga gucuccaaau 20
<210> 432
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 432
aaaucacccc caaccgcacc 20
<210> 433
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 433
aaccuccgag ucuccaaauc 20
<210> 434
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 434
aaucaccccc aaccgcacca 20
<210> 435
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 435
accuccgagu cuccaaauca 20
<210> 436
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 436
agucuccaaa ucacccccaa 20
<210> 437
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 437
auggugcggu ugggggugau 20
<210> 438
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 438
auuuggagac ucggagguuu 20
<210> 439
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 439
caaaucaccc ccaaccgcac 20
<210> 440
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 440
ccaaaucacc cccaaccgca 20
<210> 441
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 441
ccgagucucc aaaucacccc 20
<210> 442
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 442
ccuccgaguc uccaaaucac 20
<210> 443
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 443
cgagucucca aaucaccccc 20
<210> 444
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 444
cgguuggggg ugauuuggag 20
<210> 445
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 445
cuccaaauca cccccaaccg 20
<210> 446
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 446
cuccgagucu ccaaaucacc 20
<210> 447
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 447
gagucuccaa aucaccccca 20
<210> 448
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 448
gauggugcgg uuggggguga 20
<210> 449
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 449
gauuuggaga cucggagguu 20
<210> 450
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 450
gcgguugggg gugauuugga 20
<210> 451
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 451
gggggugauu uggagacucg 20
<210> 452
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 452
ggggugauuu ggagacucgg 20
<210> 453
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 453
gggugauuug gagacucgga 20
<210> 454
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 454
ggugauuugg agacucggag 20
<210> 455
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 455
ggugcgguug ggggugauuu 20
<210> 456
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 456
gguugggggu gauuuggaga 20
<210> 457
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 457
gucuccaaau cacccccaac 20
<210> 458
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 458
gugauuugga gacucggagg 20
<210> 459
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 459
gugcgguugg gggugauuug 20
<210> 460
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 460
guugggggug auuuggagac 20
<210> 461
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 461
uccaaaucac ccccaaccgc 20
<210> 462
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 462
uccgagucuc caaaucaccc 20
<210> 463
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 463
ucuccaaauc acccccaacc 20
<210> 464
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 464
ugauuuggag acucggaggu 20
<210> 465
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 465
ugcgguuggg ggugauuugg 20
<210> 466
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 466
ugggggugau uuggagacuc 20
<210> 467
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 467
uggugcgguu gggggugauu 20
<210> 468
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 468
uuggggguga uuuggagacu 20
<210> 469
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 469
aaaccuccga gucuccaaau c 21
<210> 470
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 470
aaaucacccc caaccgcacc a 21
<210> 471
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 471
aaccuccgag ucuccaaauc a 21
<210> 472
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 472
aaucaccccc aaccgcacca u 21
<210> 473
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 473
accuccgagu cuccaaauca c 21
<210> 474
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 474
agucuccaaa ucacccccaa c 21
<210> 475
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 475
auggugcggu ugggggugau u 21
<210> 476
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 476
auuuggagac ucggagguuu g 21
<210> 477
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 477
caaaccuccg agucuccaaa u 21
<210> 478
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 478
caaaucaccc ccaaccgcac c 21
<210> 479
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 479
ccaaaucacc cccaaccgca c 21
<210> 480
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 480
ccgagucucc aaaucacccc c 21
<210> 481
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 481
ccuccgaguc uccaaaucac c 21
<210> 482
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 482
cgagucucca aaucaccccc a 21
<210> 483
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 483
cgguuggggg ugauuuggag a 21
<210> 484
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 484
cuccaaauca cccccaaccg c 21
<210> 485
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 485
cuccgagucu ccaaaucacc c 21
<210> 486
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 486
gagucuccaa aucaccccca a 21
<210> 487
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 487
gauggugcgg uuggggguga u 21
<210> 488
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 488
gauuuggaga cucggagguu u 21
<210> 489
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 489
gcgguugggg gugauuugga g 21
<210> 490
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 490
gggggugauu uggagacucg g 21
<210> 491
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 491
ggggugauuu ggagacucgg a 21
<210> 492
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 492
gggugauuug gagacucgga g 21
<210> 493
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 493
ggugauuugg agacucggag g 21
<210> 494
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 494
ggugcgguug ggggugauuu g 21
<210> 495
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 495
gguugggggu gauuuggaga c 21
<210> 496
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 496
gucuccaaau cacccccaac c 21
<210> 497
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 497
gugauuugga gacucggagg u 21
<210> 498
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 498
gugcgguugg gggugauuug g 21
<210> 499
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 499
guugggggug auuuggagac u 21
<210> 500
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 500
uccaaaucac ccccaaccgc a 21
<210> 501
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 501
uccgagucuc caaaucaccc c 21
<210> 502
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 502
ucuccaaauc acccccaacc g 21
<210> 503
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 503
ugauggugcg guugggggug a 21
<210> 504
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 504
ugauuuggag acucggaggu u 21
<210> 505
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 505
ugcgguuggg ggugauuugg a 21
<210> 506
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 506
ugggggugau uuggagacuc g 21
<210> 507
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 507
uggugcgguu gggggugauu u 21
<210> 508
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 508
uuggggguga uuuggagacu c 21
<210> 509
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 509
aaaccuccga gucuccaaau ca 22
<210> 510
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 510
aaaucacccc caaccgcacc au 22
<210> 511
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 511
aaccuccgag ucuccaaauc ac 22
<210> 512
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 512
aaucaccccc aaccgcacca uc 22
<210> 513
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 513
accuccgagu cuccaaauca cc 22
<210> 514
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 514
agucuccaaa ucacccccaa cc 22
<210> 515
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 515
auggugcggu ugggggugau uu 22
<210> 516
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 516
auuuggagac ucggagguuu gg 22
<210> 517
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 517
caaaccuccg agucuccaaa uc 22
<210> 518
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 518
caaaucaccc ccaaccgcac ca 22
<210> 519
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 519
ccaaaccucc gagucuccaa au 22
<210> 520
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 520
ccaaaucacc cccaaccgca cc 22
<210> 521
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 521
ccgagucucc aaaucacccc ca 22
<210> 522
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 522
ccuccgaguc uccaaaucac cc 22
<210> 523
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 523
cgagucucca aaucaccccc aa 22
<210> 524
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 524
cgguuggggg ugauuuggag ac 22
<210> 525
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 525
cuccaaauca cccccaaccg ca 22
<210> 526
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 526
cuccgagucu ccaaaucacc cc 22
<210> 527
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 527
gagucuccaa aucaccccca ac 22
<210> 528
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 528
gauggugcgg uuggggguga uu 22
<210> 529
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 529
gauuuggaga cucggagguu ug 22
<210> 530
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 530
gcgguugggg gugauuugga ga 22
<210> 531
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 531
gggggugauu uggagacucg ga 22
<210> 532
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 532
ggggugauuu ggagacucgg ag 22
<210> 533
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 533
gggugauuug gagacucgga gg 22
<210> 534
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 534
ggugauuugg agacucggag gu 22
<210> 535
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 535
ggugcgguug ggggugauuu gg 22
<210> 536
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 536
gguugggggu gauuuggaga cu 22
<210> 537
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 537
gucuccaaau cacccccaac cg 22
<210> 538
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 538
gugauuugga gacucggagg uu 22
<210> 539
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 539
gugcgguugg gggugauuug ga 22
<210> 540
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 540
guugggggug auuuggagac uc 22
<210> 541
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 541
uccaaaucac ccccaaccgc ac 22
<210> 542
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 542
uccgagucuc caaaucaccc cc 22
<210> 543
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 543
ucuccaaauc acccccaacc gc 22
<210> 544
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 544
ugauggugcg guugggggug au 22
<210> 545
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 545
ugauuuggag acucggaggu uu 22
<210> 546
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 546
ugcgguuggg ggugauuugg ag 22
<210> 547
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 547
ugggggugau uuggagacuc gg 22
<210> 548
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 548
uggugcgguu gggggugauu ug 22
<210> 549
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 549
uugauggugc gguugggggu ga 22
<210> 550
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 550
uuggggguga uuuggagacu cg 22
<210> 551
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 551
acacccccaa ccgcaccauc 20
<210> 552
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 552
cacccccaac cgcaccauca 20
<210> 553
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 553
guucauugau ggugcgguug 20
<210> 554
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 554
uguucauuga uggugcgguu 20
<210> 555
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 555
acacccccaa ccgcaccauc a 21
<210> 556
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 556
cacccccaac cgcaccauca a 21
<210> 557
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 557
guguucauug auggugcggu u 21
<210> 558
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 558
uguucauuga uggugcgguu g 21
<210> 559
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 559
acacccccaa ccgcaccauc aa 22
<210> 560
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 560
cacccccaac cgcaccauca au 22
<210> 561
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 561
gguguucauu gauggugcgg uu 22
<210> 562
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 562
guguucauug auggugcggu ug 22
<210> 563
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 563
aaacacccca accgcaccau 20
<210> 564
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 564
aacaccccaa ccgcaccauc 20
<210> 565
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 565
acaccccaac cgcaccauca 20
<210> 566
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 566
agucuccaaa caccccaacc 20
<210> 567
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 567
auggugcggu ugggguguuu 20
<210> 568
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 568
auugauggug cgguuggggu 20
<210> 569
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 569
caaacacccc aaccgcacca 20
<210> 570
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 570
caccccaacc gcaccaucaa 20
<210> 571
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 571
ccaaacaccc caaccgcacc 20
<210> 572
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 572
ccgagucucc aaacacccca 20
<210> 573
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 573
cgagucucca aacaccccaa 20
<210> 574
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 574
cgguuggggu guuuggagac 20
<210> 575
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 575
cuccaaacac cccaaccgca 20
<210> 576
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 576
gagucuccaa acaccccaac 20
<210> 577
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 577
gauggugcgg uugggguguu 20
<210> 578
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 578
gcgguugggg uguuuggaga 20
<210> 579
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 579
ggugcgguug ggguguuugg 20
<210> 580
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 580
gguuggggug uuuggagacu 20
<210> 581
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 581
gucuccaaac accccaaccg 20
<210> 582
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 582
gugcgguugg gguguuugga 20
<210> 583
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 583
guguucauug auggugcggu 20
<210> 584
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 584
guuggggugu uuggagacuc 20
<210> 585
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 585
uccaaacacc ccaaccgcac 20
<210> 586
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 586
ucuccaaaca ccccaaccgc 20
<210> 587
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 587
ugauggugcg guuggggugu 20
<210> 588
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 588
ugcgguuggg guguuuggag 20
<210> 589
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 589
ugggguguuu ggagacucgg 20
<210> 590
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 590
uggugcgguu gggguguuug 20
<210> 591
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 591
uugauggugc gguuggggug 20
<210> 592
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 592
uugggguguu uggagacucg 20
<210> 593
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 593
aaacacccca accgcaccau c 21
<210> 594
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 594
aacaccccaa ccgcaccauc a 21
<210> 595
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 595
acaccccaac cgcaccauca a 21
<210> 596
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 596
agucuccaaa caccccaacc g 21
<210> 597
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 597
auggugcggu ugggguguuu g 21
<210> 598
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 598
auugauggug cgguuggggu g 21
<210> 599
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 599
caaacacccc aaccgcacca u 21
<210> 600
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 600
caccccaacc gcaccaucaa u 21
<210> 601
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 601
cauugauggu gcgguugggg u 21
<210> 602
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 602
ccaaacaccc caaccgcacc a 21
<210> 603
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 603
ccgagucucc aaacacccca a 21
<210> 604
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 604
cgagucucca aacaccccaa c 21
<210> 605
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 605
cgguuggggu guuuggagac u 21
<210> 606
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 606
cuccaaacac cccaaccgca c 21
<210> 607
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 607
gagucuccaa acaccccaac c 21
<210> 608
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 608
gauggugcgg uugggguguu u 21
<210> 609
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 609
gcgguugggg uguuuggaga c 21
<210> 610
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 610
ggugcgguug ggguguuugg a 21
<210> 611
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 611
gguguucauu gauggugcgg u 21
<210> 612
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 612
gguuggggug uuuggagacu c 21
<210> 613
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 613
gucuccaaac accccaaccg c 21
<210> 614
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 614
gugcgguugg gguguuugga g 21
<210> 615
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 615
guuggggugu uuggagacuc g 21
<210> 616
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 616
uccaaacacc ccaaccgcac c 21
<210> 617
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 617
uccgagucuc caaacacccc a 21
<210> 618
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 618
ucuccaaaca ccccaaccgc a 21
<210> 619
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 619
ugauggugcg guuggggugu u 21
<210> 620
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 620
ugcgguuggg guguuuggag a 21
<210> 621
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 621
ugggguguuu ggagacucgg a 21
<210> 622
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 622
uggugcgguu gggguguuug g 21
<210> 623
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 623
uugauggugc gguuggggug u 21
<210> 624
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 624
uugggguguu uggagacucg g 21
<210> 625
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 625
aaacacccca accgcaccau ca 22
<210> 626
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 626
aacaccccaa ccgcaccauc aa 22
<210> 627
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 627
acaccccaac cgcaccauca au 22
<210> 628
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 628
agucuccaaa caccccaacc gc 22
<210> 629
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 629
auggugcggu ugggguguuu gg 22
<210> 630
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 630
auugauggug cgguuggggu gu 22
<210> 631
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 631
caaacacccc aaccgcacca uc 22
<210> 632
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 632
caccccaacc gcaccaucaa ug 22
<210> 633
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 633
cauugauggu gcgguugggg ug 22
<210> 634
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 634
ccaaacaccc caaccgcacc au 22
<210> 635
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 635
ccgagucucc aaacacccca ac 22
<210> 636
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 636
cgagucucca aacaccccaa cc 22
<210> 637
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 637
cgguuggggu guuuggagac uc 22
<210> 638
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 638
cuccaaacac cccaaccgca cc 22
<210> 639
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 639
cuccgagucu ccaaacaccc ca 22
<210> 640
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 640
gagucuccaa acaccccaac cg 22
<210> 641
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 641
gauggugcgg uugggguguu ug 22
<210> 642
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 642
gcgguugggg uguuuggaga cu 22
<210> 643
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 643
ggugcgguug ggguguuugg ag 22
<210> 644
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 644
gguuggggug uuuggagacu cg 22
<210> 645
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 645
gucuccaaac accccaaccg ca 22
<210> 646
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 646
gugcgguugg gguguuugga ga 22
<210> 647
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 647
guuggggugu uuggagacuc gg 22
<210> 648
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 648
ucauugaugg ugcgguuggg gu 22
<210> 649
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 649
uccaaacacc ccaaccgcac ca 22
<210> 650
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 650
uccgagucuc caaacacccc aa 22
<210> 651
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 651
ucuccaaaca ccccaaccgc ac 22
<210> 652
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 652
ugauggugcg guuggggugu uu 22
<210> 653
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 653
ugcgguuggg guguuuggag ac 22
<210> 654
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 654
ugggguguuu ggagacucgg ag 22
<210> 655
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 655
uggugcgguu gggguguuug ga 22
<210> 656
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 656
ugguguucau ugauggugcg gu 22
<210> 657
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 657
uugauggugc gguuggggug uu 22
<210> 658
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 658
uugggguguu uggagacucg ga 22
<210> 659
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 659
aaagaacucc agacacguga 20
<210> 660
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 660
aaagcuucag uuauaucuca 20
<210> 661
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 661
aaauccccag ccgccucacc 20
<210> 662
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 662
aacaggugag guuucaagua 20
<210> 663
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 663
aacuccagac acgugagaua 20
<210> 664
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 664
aacugaagcu uuaucuggag 20
<210> 665
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 665
aagaacucca gacacgugag 20
<210> 666
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 666
aagagggaga ggcugaaauc 20
<210> 667
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 667
aagcuucagu uauaucucac 20
<210> 668
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 668
aagcuuuauc uggagugggg 20
<210> 669
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 669
aaguaggaug gagcugagcu 20
<210> 670
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 670
aauccccagc cgccucaccu 20
<210> 671
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 671
acacccccau ucccccacuc 20
<210> 672
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 672
acacgugaga uauaacugaa 20
<210> 673
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 673
acaggugagg uuucaaguag 20
<210> 674
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 674
acccccauuc ccccacucca 20
<210> 675
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 675
accugcagcu cagcuccauc 20
<210> 676
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 676
acgugagaua uaacugaagc 20
<210> 677
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 677
acgugucugg aguucuuugc 20
<210> 678
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 678
acuccagaca cgugagauau 20
<210> 679
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 679
acuccagaua aagcuucagu 20
<210> 680
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 680
acugaagcuu uaucuggagu 20
<210> 681
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 681
acuugaaacc ucaccuguuc 20
<210> 682
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 682
agaacuccag acacgugaga 20
<210> 683
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 683
agacacguga gauauaacug 20
<210> 684
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 684
agaggcugaa auccccagcc 20
<210> 685
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 685
agagggagag gcugaaaucc 20
<210> 686
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 686
agauaaagcu ucaguuauau 20
<210> 687
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 687
agauauaacu gaagcuuuau 20
<210> 688
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 688
agccgccuca ccugcagcuc 20
<210> 689
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 689
agccucuccc ucuuggcaaa 20
<210> 690
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 690
agcucagcuc cauccuacuu 20
<210> 691
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 691
agcuccaucc uacuugaaac 20
<210> 692
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 692
agcugagcug caggugaggc 20
<210> 693
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 693
agcugcaggu gaggcggcug 20
<210> 694
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 694
agcuucaguu auaucucacg 20
<210> 695
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 695
agcuuuaucu ggaguggggg 20
<210> 696
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 696
aggauggagc ugagcugcag 20
<210> 697
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 697
aggcggcugg ggauuucagc 20
<210> 698
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 698
aggcugaaau ccccagccgc 20
<210> 699
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 699
agggagaggc ugaaaucccc 20
<210> 700
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 700
aggugaggcg gcuggggauu 20
<210> 701
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 701
aggugagguu ucaaguagga 20
<210> 702
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 702
agguuucaag uaggauggag 20
<210> 703
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 703
aguaggaugg agcugagcug 20
<210> 704
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 704
aguuauaucu cacgugucug 20
<210> 705
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 705
aguucuuugc caagagggag 20
<210> 706
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 706
auaaagcuuc aguuauaucu 20
<210> 707
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 707
auaacugaag cuuuaucugg 20
<210> 708
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 708
auauaacuga agcuuuaucu 20
<210> 709
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 709
auaucucacg ugucuggagu 20
<210> 710
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 710
auccccagcc gccucaccug 20
<210> 711
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 711
auccuacuug aaaccucacc 20
<210> 712
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 712
aucucacgug ucuggaguuc 20
<210> 713
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 713
aucuggagug ggggaauggg 20
<210> 714
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 714
augcgguggg aacaggugag 20
<210> 715
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 715
auggagcuga gcugcaggug 20
<210> 716
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 716
auucccccac uccagauaaa 20
<210> 717
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 717
auuucagccu cucccucuug 20
<210> 718
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 718
caaagaacuc cagacacgug 20
<210> 719
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 719
caagagggag aggcugaaau 20
<210> 720
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 720
caaguaggau ggagcugagc 20
<210> 721
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 721
cacaccccca uucccccacu 20
<210> 722
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 722
cacccccauu cccccacucc 20
<210> 723
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 723
caccugcagc ucagcuccau 20
<210> 724
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 724
cacgugagau auaacugaag 20
<210> 725
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 725
cacgugucug gaguucuuug 20
<210> 726
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 726
cacuccagau aaagcuucag 20
<210> 727
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 727
cagacacgug agauauaacu 20
<210> 728
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 728
cagauaaagc uucaguuaua 20
<210> 729
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 729
cagccgccuc accugcagcu 20
<210> 730
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 730
cagccucucc cucuuggcaa 20
<210> 731
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 731
cagcucagcu ccauccuacu 20
<210> 732
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 732
cagcuccauc cuacuugaaa 20
<210> 733
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 733
caggugaggc ggcuggggau 20
<210> 734
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 734
caggugaggu uucaaguagg 20
<210> 735
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 735
caguuauauc ucacgugucu 20
<210> 736
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 736
cauccuacuu gaaaccucac 20
<210> 737
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 737
cauuccccca cuccagauaa 20
<210> 738
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 738
ccaagaggga gaggcugaaa 20
<210> 739
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 739
ccacaccccc auucccccac 20
<210> 740
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 740
ccacuccaga uaaagcuuca 20
<210> 741
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 741
ccagacacgu gagauauaac 20
<210> 742
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 742
ccagauaaag cuucaguuau 20
<210> 743
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 743
ccagccgccu caccugcagc 20
<210> 744
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 744
ccauccuacu ugaaaccuca 20
<210> 745
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 745
ccauuccccc acuccagaua 20
<210> 746
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 746
cccacuccag auaaagcuuc 20
<210> 747
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 747
cccagccgcc ucaccugcag 20
<210> 748
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 748
cccauucccc cacuccagau 20
<210> 749
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 749
ccccacucca gauaaagcuu 20
<210> 750
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 750
ccccagccgc cucaccugca 20
<210> 751
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 751
ccccauuccc ccacuccaga 20
<210> 752
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 752
cccccacucc agauaaagcu 20
<210> 753
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 753
cccccauucc cccacuccag 20
<210> 754
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 754
cccucuuggc aaagaacucc 20
<210> 755
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 755
ccgccucacc ugcagcucag 20
<210> 756
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 756
ccuacuugaa accucaccug 20
<210> 757
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 757
ccucaccugc agcucagcuc 20
<210> 758
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 758
ccucucccuc uuggcaaaga 20
<210> 759
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 759
ccucuuggca aagaacucca 20
<210> 760
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 760
ccugcagcuc agcuccaucc 20
<210> 761
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 761
cgccucaccu gcagcucagc 20
<210> 762
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 762
cggcugggga uuucagccuc 20
<210> 763
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 763
cggugggaac aggugagguu 20
<210> 764
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 764
cgugagauau aacugaagcu 20
<210> 765
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 765
cgugucugga guucuuugcc 20
<210> 766
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 766
cuacuugaaa ccucaccugu 20
<210> 767
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 767
cucaccugca gcucagcucc 20
<210> 768
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 768
cucacguguc uggaguucuu 20
<210> 769
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 769
cucagcucca uccuacuuga 20
<210> 770
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 770
cuccagacac gugagauaua 20
<210> 771
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 771
cuccagauaa agcuucaguu 20
<210> 772
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 772
cuccauccua cuugaaaccu 20
<210> 773
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 773
cucccucuug gcaaagaacu 20
<210> 774
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 774
cucucccucu uggcaaagaa 20
<210> 775
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 775
cucuuggcaa agaacuccag 20
<210> 776
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 776
cugaaauccc cagccgccuc 20
<210> 777
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 777
cugaagcuuu aucuggagug 20
<210> 778
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 778
cugagcugca ggugaggcgg 20
<210> 779
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 779
cugcagcuca gcuccauccu 20
<210> 780
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 780
cugcagguga ggcggcuggg 20
<210> 781
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 781
cuggaguucu uugccaagag 20
<210> 782
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 782
cuggggauuu cagccucucc 20
<210> 783
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 783
cuucaguuau aucucacgug 20
<210> 784
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 784
cuugaaaccu caccuguucc 20
<210> 785
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 785
cuuggcaaag aacuccagac 20
<210> 786
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 786
cuuuaucugg agugggggaa 20
<210> 787
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 787
cuuugccaag agggagaggc 20
<210> 788
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 788
gaaaucccca gccgccucac 20
<210> 789
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 789
gaacagguga gguuucaagu 20
<210> 790
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 790
gaacuccaga cacgugagau 20
<210> 791
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 791
gaagcuuuau cuggaguggg 20
<210> 792
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 792
gacacgugag auauaacuga 20
<210> 793
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 793
gagaggcuga aauccccagc 20
<210> 794
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 794
gagauauaac ugaagcuuua 20
<210> 795
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 795
gagcugagcu gcaggugagg 20
<210> 796
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 796
gagcugcagg ugaggcggcu 20
<210> 797
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 797
gaggcggcug gggauuucag 20
<210> 798
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 798
gaggcugaaa uccccagccg 20
<210> 799
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 799
gagggagagg cugaaauccc 20
<210> 800
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 800
gagguuucaa guaggaugga 20
<210> 801
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 801
gaguucuuug ccaagaggga 20
<210> 802
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 802
gauaaagcuu caguuauauc 20
<210> 803
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 803
gauauaacug aagcuuuauc 20
<210> 804
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 804
gauggagcug agcugcaggu 20
<210> 805
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 805
gauuucagcc ucucccucuu 20
<210> 806
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 806
gcaaagaacu ccagacacgu 20
<210> 807
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 807
gcagcucagc uccauccuac 20
<210> 808
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 808
gcaggugagg cggcugggga 20
<210> 809
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 809
gccaagaggg agaggcugaa 20
<210> 810
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 810
gccgccucac cugcagcuca 20
<210> 811
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 811
gccucaccug cagcucagcu 20
<210> 812
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 812
gccucucccu cuuggcaaag 20
<210> 813
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 813
gcggcugggg auuucagccu 20
<210> 814
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 814
gcggugggaa caggugaggu 20
<210> 815
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 815
gcucagcucc auccuacuug 20
<210> 816
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 816
gcuccauccu acuugaaacc 20
<210> 817
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 817
gcugaaaucc ccagccgccu 20
<210> 818
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 818
gcugagcugc aggugaggcg 20
<210> 819
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 819
gcugcaggug aggcggcugg 20
<210> 820
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 820
gcuggggauu ucagccucuc 20
<210> 821
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 821
gcuucaguua uaucucacgu 20
<210> 822
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 822
gcuuuaucug gaguggggga 20
<210> 823
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 823
ggaacaggug agguuucaag 20
<210> 824
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 824
ggagaggcug aaauccccag 20
<210> 825
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 825
ggagcugagc ugcaggugag 20
<210> 826
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 826
ggaguucuuu gccaagaggg 20
<210> 827
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 827
ggauggagcu gagcugcagg 20
<210> 828
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 828
ggauuucagc cucucccucu 20
<210> 829
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 829
ggcaaagaac uccagacacg 20
<210> 830
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 830
ggcggcuggg gauuucagcc 20
<210> 831
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 831
ggcugaaauc cccagccgcc 20
<210> 832
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 832
ggcuggggau uucagccucu 20
<210> 833
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 833
gggaacaggu gagguuucaa 20
<210> 834
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 834
gggagaggcu gaaaucccca 20
<210> 835
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 835
gggauuucag ccucucccuc 20
<210> 836
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 836
ggggauuuca gccucucccu 20
<210> 837
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 837
ggugaggcgg cuggggauuu 20
<210> 838
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 838
ggugagguuu caaguaggau 20
<210> 839
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 839
ggugggaaca ggugagguuu 20
<210> 840
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 840
gguuucaagu aggauggagc 20
<210> 841
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 841
guaggaugga gcugagcugc 20
<210> 842
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 842
gucuggaguu cuuugccaag 20
<210> 843
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 843
gugagauaua acugaagcuu 20
<210> 844
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 844
gugaggcggc uggggauuuc 20
<210> 845
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 845
gugagguuuc aaguaggaug 20
<210> 846
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 846
gugggaacag gugagguuuc 20
<210> 847
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 847
gugucuggag uucuuugcca 20
<210> 848
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 848
guuauaucuc acgugucugg 20
<210> 849
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 849
guucuuugcc aagagggaga 20
<210> 850
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 850
guuucaagua ggauggagcu 20
<210> 851
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 851
uaaagcuuca guuauaucuc 20
<210> 852
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 852
uaacugaagc uuuaucugga 20
<210> 853
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 853
uacuugaaac cucaccuguu 20
<210> 854
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 854
uaggauggag cugagcugca 20
<210> 855
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 855
uauaacugaa gcuuuaucug 20
<210> 856
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 856
uauaucucac gugucuggag 20
<210> 857
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 857
uaucucacgu gucuggaguu 20
<210> 858
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 858
uaucuggagu gggggaaugg 20
<210> 859
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 859
ucaaguagga uggagcugag 20
<210> 860
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 860
ucaccugcag cucagcucca 20
<210> 861
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 861
ucacgugucu ggaguucuuu 20
<210> 862
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 862
ucagccucuc ccucuuggca 20
<210> 863
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 863
ucagcuccau ccuacuugaa 20
<210> 864
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 864
ucaguuauau cucacguguc 20
<210> 865
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 865
uccagacacg ugagauauaa 20
<210> 866
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 866
uccagauaaa gcuucaguua 20
<210> 867
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 867
uccauccuac uugaaaccuc 20
<210> 868
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 868
uccccagccg ccucaccugc 20
<210> 869
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 869
ucccccacuc cagauaaagc 20
<210> 870
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 870
ucccucuugg caaagaacuc 20
<210> 871
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 871
uccuacuuga aaccucaccu 20
<210> 872
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 872
ucucacgugu cuggaguucu 20
<210> 873
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 873
ucucccucuu ggcaaagaac 20
<210> 874
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 874
ucuggagugg gggaaugggg 20
<210> 875
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 875
ucuggaguuc uuugccaaga 20
<210> 876
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 876
ucuuggcaaa gaacuccaga 20
<210> 877
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 877
ucuuugccaa gagggagagg 20
<210> 878
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 878
ugaaaccuca ccuguuccca 20
<210> 879
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 879
ugaaaucccc agccgccuca 20
<210> 880
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 880
ugaagcuuua ucuggagugg 20
<210> 881
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 881
ugagauauaa cugaagcuuu 20
<210> 882
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 882
ugagcugcag gugaggcggc 20
<210> 883
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 883
ugaggcggcu ggggauuuca 20
<210> 884
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 884
ugagguuuca aguaggaugg 20
<210> 885
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 885
ugcagcucag cuccauccua 20
<210> 886
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 886
ugcaggugag gcggcugggg 20
<210> 887
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 887
ugccaagagg gagaggcuga 20
<210> 888
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 888
ugcgguggga acaggugagg 20
<210> 889
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 889
uggagcugag cugcagguga 20
<210> 890
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 890
uggaguucuu ugccaagagg 20
<210> 891
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 891
uggcaaagaa cuccagacac 20
<210> 892
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 892
ugggaacagg ugagguuuca 20
<210> 893
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 893
uggggauuuc agccucuccc 20
<210> 894
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 894
ugucuggagu ucuuugccaa 20
<210> 895
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 895
uuauaucuca cgugucugga 20
<210> 896
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 896
uuaucuggag ugggggaaug 20
<210> 897
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 897
uucaaguagg auggagcuga 20
<210> 898
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 898
uucagccucu cccucuuggc 20
<210> 899
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 899
uucaguuaua ucucacgugu 20
<210> 900
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 900
uucccccacu ccagauaaag 20
<210> 901
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 901
uucuuugcca agagggagag 20
<210> 902
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 902
uugaaaccuc accuguuccc 20
<210> 903
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 903
uugccaagag ggagaggcug 20
<210> 904
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 904
uuggcaaaga acuccagaca 20
<210> 905
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 905
uuuaucugga gugggggaau 20
<210> 906
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 906
uuucaaguag gauggagcug 20
<210> 907
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 907
uuucagccuc ucccucuugg 20
<210> 908
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 908
uuugccaaga gggagaggcu 20
<210> 909
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 909
aaagaacucc agacacguga g 21
<210> 910
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 910
aaagcuucag uuauaucuca c 21
<210> 911
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 911
aaauccccag ccgccucacc u 21
<210> 912
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 912
aacaggugag guuucaagua g 21
<210> 913
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 913
aacuccagac acgugagaua u 21
<210> 914
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 914
aacugaagcu uuaucuggag u 21
<210> 915
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 915
aagaacucca gacacgugag a 21
<210> 916
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 916
aagagggaga ggcugaaauc c 21
<210> 917
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 917
aagcuucagu uauaucucac g 21
<210> 918
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 918
aagcuuuauc uggagugggg g 21
<210> 919
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 919
aaguaggaug gagcugagcu g 21
<210> 920
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 920
aauccccagc cgccucaccu g 21
<210> 921
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 921
acacccccau ucccccacuc c 21
<210> 922
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 922
acacgugaga uauaacugaa g 21
<210> 923
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 923
acaggugagg uuucaaguag g 21
<210> 924
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 924
acccccauuc ccccacucca g 21
<210> 925
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 925
accugcagcu cagcuccauc c 21
<210> 926
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 926
acgugagaua uaacugaagc u 21
<210> 927
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 927
acgugucugg aguucuuugc c 21
<210> 928
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 928
acuccagaca cgugagauau a 21
<210> 929
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 929
acuccagaua aagcuucagu u 21
<210> 930
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 930
acugaagcuu uaucuggagu g 21
<210> 931
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 931
acuugaaacc ucaccuguuc c 21
<210> 932
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 932
agaacuccag acacgugaga u 21
<210> 933
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 933
agacacguga gauauaacug a 21
<210> 934
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 934
agaggcugaa auccccagcc g 21
<210> 935
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 935
agagggagag gcugaaaucc c 21
<210> 936
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 936
agauaaagcu ucaguuauau c 21
<210> 937
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 937
agauauaacu gaagcuuuau c 21
<210> 938
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 938
agccgccuca ccugcagcuc a 21
<210> 939
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 939
agccucuccc ucuuggcaaa g 21
<210> 940
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 940
agcucagcuc cauccuacuu g 21
<210> 941
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 941
agcuccaucc uacuugaaac c 21
<210> 942
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 942
agcugagcug caggugaggc g 21
<210> 943
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 943
agcugcaggu gaggcggcug g 21
<210> 944
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 944
agcuucaguu auaucucacg u 21
<210> 945
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 945
agcuuuaucu ggaguggggg a 21
<210> 946
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 946
aggauggagc ugagcugcag g 21
<210> 947
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 947
aggcggcugg ggauuucagc c 21
<210> 948
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 948
aggcugaaau ccccagccgc c 21
<210> 949
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 949
agggagaggc ugaaaucccc a 21
<210> 950
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 950
aggugaggcg gcuggggauu u 21
<210> 951
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 951
aggugagguu ucaaguagga u 21
<210> 952
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 952
agguuucaag uaggauggag c 21
<210> 953
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 953
aguaggaugg agcugagcug c 21
<210> 954
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 954
aguuauaucu cacgugucug g 21
<210> 955
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 955
aguucuuugc caagagggag a 21
<210> 956
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 956
auaaagcuuc aguuauaucu c 21
<210> 957
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 957
auaacugaag cuuuaucugg a 21
<210> 958
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 958
auauaacuga agcuuuaucu g 21
<210> 959
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 959
auaucucacg ugucuggagu u 21
<210> 960
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 960
auccccagcc gccucaccug c 21
<210> 961
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 961
auccuacuug aaaccucacc u 21
<210> 962
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 962
aucucacgug ucuggaguuc u 21
<210> 963
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 963
aucuggagug ggggaauggg g 21
<210> 964
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 964
augcgguggg aacaggugag g 21
<210> 965
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 965
auggagcuga gcugcaggug a 21
<210> 966
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 966
auucccccac uccagauaaa g 21
<210> 967
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 967
auuucagccu cucccucuug g 21
<210> 968
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 968
caaagaacuc cagacacgug a 21
<210> 969
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 969
caagagggag aggcugaaau c 21
<210> 970
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 970
caaguaggau ggagcugagc u 21
<210> 971
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 971
cacaccccca uucccccacu c 21
<210> 972
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 972
cacccccauu cccccacucc a 21
<210> 973
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 973
caccugcagc ucagcuccau c 21
<210> 974
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 974
cacgugagau auaacugaag c 21
<210> 975
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 975
cacgugucug gaguucuuug c 21
<210> 976
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 976
cacuccagau aaagcuucag u 21
<210> 977
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 977
cagacacgug agauauaacu g 21
<210> 978
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 978
cagauaaagc uucaguuaua u 21
<210> 979
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 979
cagccgccuc accugcagcu c 21
<210> 980
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 980
cagccucucc cucuuggcaa a 21
<210> 981
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 981
cagcucagcu ccauccuacu u 21
<210> 982
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 982
cagcuccauc cuacuugaaa c 21
<210> 983
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 983
caggugaggc ggcuggggau u 21
<210> 984
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 984
caggugaggu uucaaguagg a 21
<210> 985
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 985
caguuauauc ucacgugucu g 21
<210> 986
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 986
cauccuacuu gaaaccucac c 21
<210> 987
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 987
cauuccccca cuccagauaa a 21
<210> 988
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 988
ccaagaggga gaggcugaaa u 21
<210> 989
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 989
ccacaccccc auucccccac u 21
<210> 990
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 990
ccacuccaga uaaagcuuca g 21
<210> 991
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 991
ccagacacgu gagauauaac u 21
<210> 992
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 992
ccagauaaag cuucaguuau a 21
<210> 993
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 993
ccagccgccu caccugcagc u 21
<210> 994
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 994
ccauccuacu ugaaaccuca c 21
<210> 995
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 995
ccauuccccc acuccagaua a 21
<210> 996
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 996
cccacuccag auaaagcuuc a 21
<210> 997
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 997
cccagccgcc ucaccugcag c 21
<210> 998
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 998
cccauucccc cacuccagau a 21
<210> 999
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 999
ccccacucca gauaaagcuu c 21
<210> 1000
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1000
ccccagccgc cucaccugca g 21
<210> 1001
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1001
ccccauuccc ccacuccaga u 21
<210> 1002
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1002
cccccacucc agauaaagcu u 21
<210> 1003
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1003
cccccauucc cccacuccag a 21
<210> 1004
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1004
cccucuuggc aaagaacucc a 21
<210> 1005
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1005
ccgccucacc ugcagcucag c 21
<210> 1006
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1006
ccuacuugaa accucaccug u 21
<210> 1007
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1007
ccucaccugc agcucagcuc c 21
<210> 1008
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1008
ccucucccuc uuggcaaaga a 21
<210> 1009
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1009
ccucuuggca aagaacucca g 21
<210> 1010
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1010
ccugcagcuc agcuccaucc u 21
<210> 1011
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1011
cgccucaccu gcagcucagc u 21
<210> 1012
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1012
cggcugggga uuucagccuc u 21
<210> 1013
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1013
cggugggaac aggugagguu u 21
<210> 1014
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1014
cgugagauau aacugaagcu u 21
<210> 1015
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1015
cgugucugga guucuuugcc a 21
<210> 1016
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1016
cuacuugaaa ccucaccugu u 21
<210> 1017
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1017
cucaccugca gcucagcucc a 21
<210> 1018
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1018
cucacguguc uggaguucuu u 21
<210> 1019
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1019
cucagcucca uccuacuuga a 21
<210> 1020
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1020
cuccagacac gugagauaua a 21
<210> 1021
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1021
cuccagauaa agcuucaguu a 21
<210> 1022
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1022
cuccauccua cuugaaaccu c 21
<210> 1023
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1023
cucccucuug gcaaagaacu c 21
<210> 1024
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1024
cucucccucu uggcaaagaa c 21
<210> 1025
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1025
cucuuggcaa agaacuccag a 21
<210> 1026
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1026
cugaaauccc cagccgccuc a 21
<210> 1027
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1027
cugaagcuuu aucuggagug g 21
<210> 1028
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1028
cugagcugca ggugaggcgg c 21
<210> 1029
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1029
cugcagcuca gcuccauccu a 21
<210> 1030
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1030
cugcagguga ggcggcuggg g 21
<210> 1031
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1031
cuggaguucu uugccaagag g 21
<210> 1032
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1032
cuggggauuu cagccucucc c 21
<210> 1033
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1033
cuucaguuau aucucacgug u 21
<210> 1034
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1034
cuugaaaccu caccuguucc c 21
<210> 1035
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1035
cuuggcaaag aacuccagac a 21
<210> 1036
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1036
cuuuaucugg agugggggaa u 21
<210> 1037
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1037
cuuugccaag agggagaggc u 21
<210> 1038
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1038
gaaaucccca gccgccucac c 21
<210> 1039
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1039
gaacagguga gguuucaagu a 21
<210> 1040
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1040
gaacuccaga cacgugagau a 21
<210> 1041
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1041
gaagcuuuau cuggaguggg g 21
<210> 1042
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1042
gacacgugag auauaacuga a 21
<210> 1043
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1043
gagaggcuga aauccccagc c 21
<210> 1044
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1044
gagauauaac ugaagcuuua u 21
<210> 1045
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1045
gagcugagcu gcaggugagg c 21
<210> 1046
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1046
gagcugcagg ugaggcggcu g 21
<210> 1047
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1047
gaggcggcug gggauuucag c 21
<210> 1048
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1048
gaggcugaaa uccccagccg c 21
<210> 1049
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1049
gagggagagg cugaaauccc c 21
<210> 1050
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1050
gagguuucaa guaggaugga g 21
<210> 1051
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1051
gaguucuuug ccaagaggga g 21
<210> 1052
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1052
gauaaagcuu caguuauauc u 21
<210> 1053
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1053
gauauaacug aagcuuuauc u 21
<210> 1054
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1054
gauggagcug agcugcaggu g 21
<210> 1055
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1055
gauuucagcc ucucccucuu g 21
<210> 1056
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1056
gcaaagaacu ccagacacgu g 21
<210> 1057
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1057
gcagcucagc uccauccuac u 21
<210> 1058
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1058
gcaggugagg cggcugggga u 21
<210> 1059
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1059
gccaagaggg agaggcugaa a 21
<210> 1060
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1060
gccgccucac cugcagcuca g 21
<210> 1061
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1061
gccucaccug cagcucagcu c 21
<210> 1062
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1062
gccucucccu cuuggcaaag a 21
<210> 1063
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1063
gcggcugggg auuucagccu c 21
<210> 1064
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1064
gcggugggaa caggugaggu u 21
<210> 1065
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1065
gcucagcucc auccuacuug a 21
<210> 1066
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1066
gcuccauccu acuugaaacc u 21
<210> 1067
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1067
gcugaaaucc ccagccgccu c 21
<210> 1068
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1068
gcugagcugc aggugaggcg g 21
<210> 1069
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1069
gcugcaggug aggcggcugg g 21
<210> 1070
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1070
gcuggggauu ucagccucuc c 21
<210> 1071
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1071
gcuucaguua uaucucacgu g 21
<210> 1072
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1072
gcuuuaucug gaguggggga a 21
<210> 1073
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1073
ggaacaggug agguuucaag u 21
<210> 1074
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1074
ggagaggcug aaauccccag c 21
<210> 1075
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1075
ggagcugagc ugcaggugag g 21
<210> 1076
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1076
ggaguucuuu gccaagaggg a 21
<210> 1077
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1077
ggauggagcu gagcugcagg u 21
<210> 1078
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1078
ggauuucagc cucucccucu u 21
<210> 1079
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1079
ggcaaagaac uccagacacg u 21
<210> 1080
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1080
ggcggcuggg gauuucagcc u 21
<210> 1081
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1081
ggcugaaauc cccagccgcc u 21
<210> 1082
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1082
ggcuggggau uucagccucu c 21
<210> 1083
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1083
gggaacaggu gagguuucaa g 21
<210> 1084
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1084
gggagaggcu gaaaucccca g 21
<210> 1085
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1085
gggauuucag ccucucccuc u 21
<210> 1086
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1086
ggggauuuca gccucucccu c 21
<210> 1087
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1087
ggugaggcgg cuggggauuu c 21
<210> 1088
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1088
ggugagguuu caaguaggau g 21
<210> 1089
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1089
ggugggaaca ggugagguuu c 21
<210> 1090
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1090
gguuucaagu aggauggagc u 21
<210> 1091
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1091
guaggaugga gcugagcugc a 21
<210> 1092
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1092
gucuggaguu cuuugccaag a 21
<210> 1093
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1093
gugagauaua acugaagcuu u 21
<210> 1094
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1094
gugaggcggc uggggauuuc a 21
<210> 1095
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1095
gugagguuuc aaguaggaug g 21
<210> 1096
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1096
gugggaacag gugagguuuc a 21
<210> 1097
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1097
gugucuggag uucuuugcca a 21
<210> 1098
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1098
guuauaucuc acgugucugg a 21
<210> 1099
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1099
guucuuugcc aagagggaga g 21
<210> 1100
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1100
guuucaagua ggauggagcu g 21
<210> 1101
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1101
uaaagcuuca guuauaucuc a 21
<210> 1102
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1102
uaacugaagc uuuaucugga g 21
<210> 1103
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1103
uacuugaaac cucaccuguu c 21
<210> 1104
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1104
uaggauggag cugagcugca g 21
<210> 1105
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1105
uauaacugaa gcuuuaucug g 21
<210> 1106
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1106
uauaucucac gugucuggag u 21
<210> 1107
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1107
uaucucacgu gucuggaguu c 21
<210> 1108
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1108
uaucuggagu gggggaaugg g 21
<210> 1109
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1109
ucaaguagga uggagcugag c 21
<210> 1110
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1110
ucaccugcag cucagcucca u 21
<210> 1111
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1111
ucacgugucu ggaguucuuu g 21
<210> 1112
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1112
ucagccucuc ccucuuggca a 21
<210> 1113
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1113
ucagcuccau ccuacuugaa a 21
<210> 1114
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1114
ucaguuauau cucacguguc u 21
<210> 1115
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1115
uccagacacg ugagauauaa c 21
<210> 1116
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1116
uccagauaaa gcuucaguua u 21
<210> 1117
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1117
uccauccuac uugaaaccuc a 21
<210> 1118
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1118
uccccagccg ccucaccugc a 21
<210> 1119
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1119
ucccccacuc cagauaaagc u 21
<210> 1120
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1120
ucccucuugg caaagaacuc c 21
<210> 1121
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1121
uccuacuuga aaccucaccu g 21
<210> 1122
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1122
ucucacgugu cuggaguucu u 21
<210> 1123
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1123
ucucccucuu ggcaaagaac u 21
<210> 1124
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1124
ucuggaguuc uuugccaaga g 21
<210> 1125
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1125
ucuuggcaaa gaacuccaga c 21
<210> 1126
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1126
ucuuugccaa gagggagagg c 21
<210> 1127
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1127
ugaaaucccc agccgccuca c 21
<210> 1128
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1128
ugaagcuuua ucuggagugg g 21
<210> 1129
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1129
ugagauauaa cugaagcuuu a 21
<210> 1130
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1130
ugagcugcag gugaggcggc u 21
<210> 1131
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1131
ugaggcggcu ggggauuuca g 21
<210> 1132
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1132
ugagguuuca aguaggaugg a 21
<210> 1133
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1133
ugcagcucag cuccauccua c 21
<210> 1134
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1134
ugcaggugag gcggcugggg a 21
<210> 1135
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1135
ugccaagagg gagaggcuga a 21
<210> 1136
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1136
ugcgguggga acaggugagg u 21
<210> 1137
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1137
uggagcugag cugcagguga g 21
<210> 1138
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1138
uggaguucuu ugccaagagg g 21
<210> 1139
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1139
uggcaaagaa cuccagacac g 21
<210> 1140
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1140
ugggaacagg ugagguuuca a 21
<210> 1141
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1141
uggggauuuc agccucuccc u 21
<210> 1142
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1142
ugucuggagu ucuuugccaa g 21
<210> 1143
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1143
uuauaucuca cgugucugga g 21
<210> 1144
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1144
uuaucuggag ugggggaaug g 21
<210> 1145
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1145
uucaaguagg auggagcuga g 21
<210> 1146
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1146
uucagccucu cccucuuggc a 21
<210> 1147
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1147
uucaguuaua ucucacgugu c 21
<210> 1148
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1148
uucccccacu ccagauaaag c 21
<210> 1149
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1149
uucuuugcca agagggagag g 21
<210> 1150
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1150
uugaaaccuc accuguuccc a 21
<210> 1151
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1151
uugccaagag ggagaggcug a 21
<210> 1152
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1152
uuggcaaaga acuccagaca c 21
<210> 1153
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1153
uuuaucugga gugggggaau g 21
<210> 1154
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1154
uuucaaguag gauggagcug a 21
<210> 1155
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1155
uuucagccuc ucccucuugg c 21
<210> 1156
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1156
uuugccaaga gggagaggcu g 21
<210> 1157
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1157
aaagaacucc agacacguga ga 22
<210> 1158
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1158
aaagcuucag uuauaucuca cg 22
<210> 1159
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1159
aaauccccag ccgccucacc ug 22
<210> 1160
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1160
aacaggugag guuucaagua gg 22
<210> 1161
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1161
aacuccagac acgugagaua ua 22
<210> 1162
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1162
aacugaagcu uuaucuggag ug 22
<210> 1163
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1163
aagaacucca gacacgugag au 22
<210> 1164
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1164
aagagggaga ggcugaaauc cc 22
<210> 1165
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1165
aagcuucagu uauaucucac gu 22
<210> 1166
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1166
aagcuuuauc uggagugggg ga 22
<210> 1167
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1167
aaguaggaug gagcugagcu gc 22
<210> 1168
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1168
aauccccagc cgccucaccu gc 22
<210> 1169
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1169
acacccccau ucccccacuc ca 22
<210> 1170
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1170
acacgugaga uauaacugaa gc 22
<210> 1171
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1171
acaggugagg uuucaaguag ga 22
<210> 1172
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1172
acccccauuc ccccacucca ga 22
<210> 1173
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1173
accugcagcu cagcuccauc cu 22
<210> 1174
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1174
acgugagaua uaacugaagc uu 22
<210> 1175
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1175
acgugucugg aguucuuugc ca 22
<210> 1176
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1176
acuccagaca cgugagauau aa 22
<210> 1177
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1177
acuccagaua aagcuucagu ua 22
<210> 1178
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1178
acugaagcuu uaucuggagu gg 22
<210> 1179
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1179
acuugaaacc ucaccuguuc cc 22
<210> 1180
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1180
agaacuccag acacgugaga ua 22
<210> 1181
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1181
agacacguga gauauaacug aa 22
<210> 1182
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1182
agaggcugaa auccccagcc gc 22
<210> 1183
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1183
agagggagag gcugaaaucc cc 22
<210> 1184
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1184
agauaaagcu ucaguuauau cu 22
<210> 1185
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1185
agauauaacu gaagcuuuau cu 22
<210> 1186
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1186
agccgccuca ccugcagcuc ag 22
<210> 1187
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1187
agccucuccc ucuuggcaaa ga 22
<210> 1188
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1188
agcucagcuc cauccuacuu ga 22
<210> 1189
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1189
agcuccaucc uacuugaaac cu 22
<210> 1190
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1190
agcugagcug caggugaggc gg 22
<210> 1191
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1191
agcugcaggu gaggcggcug gg 22
<210> 1192
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1192
agcuucaguu auaucucacg ug 22
<210> 1193
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1193
agcuuuaucu ggaguggggg aa 22
<210> 1194
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1194
aggauggagc ugagcugcag gu 22
<210> 1195
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1195
aggcggcugg ggauuucagc cu 22
<210> 1196
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1196
aggcugaaau ccccagccgc cu 22
<210> 1197
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1197
agggagaggc ugaaaucccc ag 22
<210> 1198
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1198
aggugaggcg gcuggggauu uc 22
<210> 1199
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1199
aggugagguu ucaaguagga ug 22
<210> 1200
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1200
agguuucaag uaggauggag cu 22
<210> 1201
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1201
aguaggaugg agcugagcug ca 22
<210> 1202
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1202
aguuauaucu cacgugucug ga 22
<210> 1203
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1203
aguucuuugc caagagggag ag 22
<210> 1204
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1204
auaaagcuuc aguuauaucu ca 22
<210> 1205
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1205
auaacugaag cuuuaucugg ag 22
<210> 1206
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1206
auauaacuga agcuuuaucu gg 22
<210> 1207
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1207
auaucucacg ugucuggagu uc 22
<210> 1208
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1208
auccccagcc gccucaccug ca 22
<210> 1209
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1209
auccuacuug aaaccucacc ug 22
<210> 1210
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1210
aucucacgug ucuggaguuc uu 22
<210> 1211
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1211
augcgguggg aacaggugag gu 22
<210> 1212
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1212
auggagcuga gcugcaggug ag 22
<210> 1213
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1213
auucccccac uccagauaaa gc 22
<210> 1214
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1214
auuucagccu cucccucuug gc 22
<210> 1215
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1215
caaagaacuc cagacacgug ag 22
<210> 1216
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1216
caagagggag aggcugaaau cc 22
<210> 1217
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1217
caaguaggau ggagcugagc ug 22
<210> 1218
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1218
cacaccccca uucccccacu cc 22
<210> 1219
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1219
cacccccauu cccccacucc ag 22
<210> 1220
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1220
caccugcagc ucagcuccau cc 22
<210> 1221
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1221
cacgugagau auaacugaag cu 22
<210> 1222
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1222
cacgugucug gaguucuuug cc 22
<210> 1223
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1223
cacuccagau aaagcuucag uu 22
<210> 1224
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1224
cagacacgug agauauaacu ga 22
<210> 1225
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1225
cagauaaagc uucaguuaua uc 22
<210> 1226
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1226
cagccgccuc accugcagcu ca 22
<210> 1227
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1227
cagccucucc cucuuggcaa ag 22
<210> 1228
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1228
cagcucagcu ccauccuacu ug 22
<210> 1229
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1229
cagcuccauc cuacuugaaa cc 22
<210> 1230
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1230
caggugaggc ggcuggggau uu 22
<210> 1231
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1231
caggugaggu uucaaguagg au 22
<210> 1232
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1232
caguuauauc ucacgugucu gg 22
<210> 1233
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1233
cauccuacuu gaaaccucac cu 22
<210> 1234
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1234
cauuccccca cuccagauaa ag 22
<210> 1235
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1235
ccaagaggga gaggcugaaa uc 22
<210> 1236
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1236
ccacaccccc auucccccac uc 22
<210> 1237
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1237
ccacuccaga uaaagcuuca gu 22
<210> 1238
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1238
ccagacacgu gagauauaac ug 22
<210> 1239
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1239
ccagauaaag cuucaguuau au 22
<210> 1240
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1240
ccagccgccu caccugcagc uc 22
<210> 1241
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1241
ccauccuacu ugaaaccuca cc 22
<210> 1242
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1242
ccauuccccc acuccagaua aa 22
<210> 1243
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1243
cccacuccag auaaagcuuc ag 22
<210> 1244
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1244
cccagccgcc ucaccugcag cu 22
<210> 1245
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1245
cccauucccc cacuccagau aa 22
<210> 1246
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1246
ccccacucca gauaaagcuu ca 22
<210> 1247
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1247
ccccagccgc cucaccugca gc 22
<210> 1248
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1248
ccccauuccc ccacuccaga ua 22
<210> 1249
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1249
cccccacucc agauaaagcu uc 22
<210> 1250
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1250
cccccauucc cccacuccag au 22
<210> 1251
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1251
cccucuuggc aaagaacucc ag 22
<210> 1252
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1252
ccgccucacc ugcagcucag cu 22
<210> 1253
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1253
ccuacuugaa accucaccug uu 22
<210> 1254
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1254
ccucaccugc agcucagcuc ca 22
<210> 1255
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1255
ccucucccuc uuggcaaaga ac 22
<210> 1256
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1256
ccucuuggca aagaacucca ga 22
<210> 1257
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1257
ccugcagcuc agcuccaucc ua 22
<210> 1258
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1258
cgccucaccu gcagcucagc uc 22
<210> 1259
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1259
cggcugggga uuucagccuc uc 22
<210> 1260
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1260
cggugggaac aggugagguu uc 22
<210> 1261
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1261
cgugagauau aacugaagcu uu 22
<210> 1262
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1262
cgugucugga guucuuugcc aa 22
<210> 1263
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1263
cuacuugaaa ccucaccugu uc 22
<210> 1264
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1264
cucaccugca gcucagcucc au 22
<210> 1265
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1265
cucacguguc uggaguucuu ug 22
<210> 1266
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1266
cucagcucca uccuacuuga aa 22
<210> 1267
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1267
cuccagacac gugagauaua ac 22
<210> 1268
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1268
cuccagauaa agcuucaguu au 22
<210> 1269
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1269
cuccauccua cuugaaaccu ca 22
<210> 1270
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1270
cucccucuug gcaaagaacu cc 22
<210> 1271
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1271
cucucccucu uggcaaagaa cu 22
<210> 1272
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1272
cucuuggcaa agaacuccag ac 22
<210> 1273
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1273
cugaaauccc cagccgccuc ac 22
<210> 1274
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1274
cugaagcuuu aucuggagug gg 22
<210> 1275
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1275
cugagcugca ggugaggcgg cu 22
<210> 1276
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1276
cugcagcuca gcuccauccu ac 22
<210> 1277
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1277
cugcagguga ggcggcuggg ga 22
<210> 1278
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1278
cuggaguucu uugccaagag gg 22
<210> 1279
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1279
cuggggauuu cagccucucc cu 22
<210> 1280
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1280
cuucaguuau aucucacgug uc 22
<210> 1281
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1281
cuugaaaccu caccuguucc ca 22
<210> 1282
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1282
cuuggcaaag aacuccagac ac 22
<210> 1283
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1283
cuuuaucugg agugggggaa ug 22
<210> 1284
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1284
cuuugccaag agggagaggc ug 22
<210> 1285
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1285
gaaaucccca gccgccucac cu 22
<210> 1286
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1286
gaacagguga gguuucaagu ag 22
<210> 1287
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1287
gaacuccaga cacgugagau au 22
<210> 1288
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1288
gaagcuuuau cuggaguggg gg 22
<210> 1289
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1289
gacacgugag auauaacuga ag 22
<210> 1290
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1290
gagaggcuga aauccccagc cg 22
<210> 1291
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1291
gagauauaac ugaagcuuua uc 22
<210> 1292
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1292
gagcugagcu gcaggugagg cg 22
<210> 1293
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1293
gagcugcagg ugaggcggcu gg 22
<210> 1294
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1294
gaggcggcug gggauuucag cc 22
<210> 1295
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1295
gaggcugaaa uccccagccg cc 22
<210> 1296
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1296
gagggagagg cugaaauccc ca 22
<210> 1297
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1297
gagguuucaa guaggaugga gc 22
<210> 1298
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1298
gaguucuuug ccaagaggga ga 22
<210> 1299
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1299
gauaaagcuu caguuauauc uc 22
<210> 1300
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1300
gauauaacug aagcuuuauc ug 22
<210> 1301
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1301
gauggagcug agcugcaggu ga 22
<210> 1302
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1302
gauuucagcc ucucccucuu gg 22
<210> 1303
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1303
gcaaagaacu ccagacacgu ga 22
<210> 1304
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1304
gcagcucagc uccauccuac uu 22
<210> 1305
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1305
gcaggugagg cggcugggga uu 22
<210> 1306
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1306
gccaagaggg agaggcugaa au 22
<210> 1307
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1307
gccgccucac cugcagcuca gc 22
<210> 1308
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1308
gccucaccug cagcucagcu cc 22
<210> 1309
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1309
gccucucccu cuuggcaaag aa 22
<210> 1310
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1310
gcggcugggg auuucagccu cu 22
<210> 1311
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1311
gcggugggaa caggugaggu uu 22
<210> 1312
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1312
gcucagcucc auccuacuug aa 22
<210> 1313
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1313
gcuccauccu acuugaaacc uc 22
<210> 1314
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1314
gcugaaaucc ccagccgccu ca 22
<210> 1315
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1315
gcugagcugc aggugaggcg gc 22
<210> 1316
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1316
gcugcaggug aggcggcugg gg 22
<210> 1317
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1317
gcuggggauu ucagccucuc cc 22
<210> 1318
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1318
gcuucaguua uaucucacgu gu 22
<210> 1319
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1319
gcuuuaucug gaguggggga au 22
<210> 1320
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1320
ggaacaggug agguuucaag ua 22
<210> 1321
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1321
ggagaggcug aaauccccag cc 22
<210> 1322
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1322
ggagcugagc ugcaggugag gc 22
<210> 1323
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1323
ggaguucuuu gccaagaggg ag 22
<210> 1324
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1324
ggauggagcu gagcugcagg ug 22
<210> 1325
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1325
ggauuucagc cucucccucu ug 22
<210> 1326
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1326
ggcaaagaac uccagacacg ug 22
<210> 1327
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1327
ggcggcuggg gauuucagcc uc 22
<210> 1328
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1328
ggcugaaauc cccagccgcc uc 22
<210> 1329
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1329
ggcuggggau uucagccucu cc 22
<210> 1330
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1330
gggaacaggu gagguuucaa gu 22
<210> 1331
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1331
gggagaggcu gaaaucccca gc 22
<210> 1332
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1332
gggauuucag ccucucccuc uu 22
<210> 1333
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1333
ggggauuuca gccucucccu cu 22
<210> 1334
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1334
ggugaggcgg cuggggauuu ca 22
<210> 1335
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1335
ggugagguuu caaguaggau gg 22
<210> 1336
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1336
ggugggaaca ggugagguuu ca 22
<210> 1337
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1337
gguuucaagu aggauggagc ug 22
<210> 1338
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1338
guaggaugga gcugagcugc ag 22
<210> 1339
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1339
gucuggaguu cuuugccaag ag 22
<210> 1340
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1340
gugagauaua acugaagcuu ua 22
<210> 1341
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1341
gugaggcggc uggggauuuc ag 22
<210> 1342
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1342
gugagguuuc aaguaggaug ga 22
<210> 1343
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1343
gugggaacag gugagguuuc aa 22
<210> 1344
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1344
gugucuggag uucuuugcca ag 22
<210> 1345
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1345
guuauaucuc acgugucugg ag 22
<210> 1346
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1346
guucuuugcc aagagggaga gg 22
<210> 1347
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1347
guuucaagua ggauggagcu ga 22
<210> 1348
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1348
uaaagcuuca guuauaucuc ac 22
<210> 1349
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1349
uaacugaagc uuuaucugga gu 22
<210> 1350
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1350
uacuugaaac cucaccuguu cc 22
<210> 1351
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1351
uaggauggag cugagcugca gg 22
<210> 1352
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1352
uauaacugaa gcuuuaucug ga 22
<210> 1353
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1353
uauaucucac gugucuggag uu 22
<210> 1354
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1354
uaucucacgu gucuggaguu cu 22
<210> 1355
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1355
uaucuggagu gggggaaugg gg 22
<210> 1356
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1356
ucaaguagga uggagcugag cu 22
<210> 1357
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1357
ucaccugcag cucagcucca uc 22
<210> 1358
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1358
ucacgugucu ggaguucuuu gc 22
<210> 1359
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1359
ucagccucuc ccucuuggca aa 22
<210> 1360
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1360
ucagcuccau ccuacuugaa ac 22
<210> 1361
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1361
ucaguuauau cucacguguc ug 22
<210> 1362
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1362
uccagacacg ugagauauaa cu 22
<210> 1363
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1363
uccagauaaa gcuucaguua ua 22
<210> 1364
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1364
uccauccuac uugaaaccuc ac 22
<210> 1365
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1365
uccccagccg ccucaccugc ag 22
<210> 1366
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1366
ucccccacuc cagauaaagc uu 22
<210> 1367
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1367
ucccucuugg caaagaacuc ca 22
<210> 1368
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1368
uccuacuuga aaccucaccu gu 22
<210> 1369
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1369
ucucacgugu cuggaguucu uu 22
<210> 1370
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1370
ucucccucuu ggcaaagaac uc 22
<210> 1371
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1371
ucuggaguuc uuugccaaga gg 22
<210> 1372
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1372
ucuuggcaaa gaacuccaga ca 22
<210> 1373
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1373
ucuuugccaa gagggagagg cu 22
<210> 1374
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1374
ugaaaucccc agccgccuca cc 22
<210> 1375
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1375
ugaagcuuua ucuggagugg gg 22
<210> 1376
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1376
ugagauauaa cugaagcuuu au 22
<210> 1377
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1377
ugagcugcag gugaggcggc ug 22
<210> 1378
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1378
ugaggcggcu ggggauuuca gc 22
<210> 1379
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1379
ugagguuuca aguaggaugg ag 22
<210> 1380
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1380
ugcagcucag cuccauccua cu 22
<210> 1381
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1381
ugcaggugag gcggcugggg au 22
<210> 1382
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1382
ugccaagagg gagaggcuga aa 22
<210> 1383
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1383
ugcgguggga acaggugagg uu 22
<210> 1384
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1384
uggagcugag cugcagguga gg 22
<210> 1385
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1385
uggaguucuu ugccaagagg ga 22
<210> 1386
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1386
uggcaaagaa cuccagacac gu 22
<210> 1387
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1387
ugggaacagg ugagguuuca ag 22
<210> 1388
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1388
uggggauuuc agccucuccc uc 22
<210> 1389
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1389
ugucuggagu ucuuugccaa ga 22
<210> 1390
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1390
uuauaucuca cgugucugga gu 22
<210> 1391
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1391
uuaucuggag ugggggaaug gg 22
<210> 1392
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1392
uucaaguagg auggagcuga gc 22
<210> 1393
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1393
uucagccucu cccucuuggc aa 22
<210> 1394
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1394
uucaguuaua ucucacgugu cu 22
<210> 1395
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1395
uucccccacu ccagauaaag cu 22
<210> 1396
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1396
uucuuugcca agagggagag gc 22
<210> 1397
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1397
uugccaagag ggagaggcug aa 22
<210> 1398
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1398
uuggcaaaga acuccagaca cg 22
<210> 1399
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1399
uuuaucugga gugggggaau gg 22
<210> 1400
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1400
uuucaaguag gauggagcug ag 22
<210> 1401
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1401
uuucagccuc ucccucuugg ca 22
<210> 1402
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1402
uuugccaaga gggagaggcu ga 22
<210> 1403
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1403
aaaaccucua aaccucaaau 20
<210> 1404
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1404
aaaauugcaa guccccaagc 20
<210> 1405
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1405
aaacacccaa acucucaggc 20
<210> 1406
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1406
aaacacccaa augcacccug 20
<210> 1407
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1407
aaacacccaa cccauaaaca 20
<210> 1408
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1408
aaacacucaa acucccggac 20
<210> 1409
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1409
aaacacucca aauauguaaa 20
<210> 1410
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1410
aaacagggcu gguucugggg 20
<210> 1411
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1411
aaacauccca aacuccaauu 20
<210> 1412
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1412
aaaccaacag augaccucaa 20
<210> 1413
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1413
aaacccacac augccccaaa 20
<210> 1414
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1414
aaacccacac ugaaaauugc 20
<210> 1415
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1415
aaacccacau acgccaaaac 20
<210> 1416
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1416
aaacccagcc uaaaccucca 20
<210> 1417
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1417
aaacccuaaa ccucuaccuc 20
<210> 1418
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1418
aaacccugaa ccuuccaacc 20
<210> 1419
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1419
aaaccucaaa ucuuagagca 20
<210> 1420
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1420
aaaccuccaa caccccaguc 20
<210> 1421
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1421
aaaccucuaa accucaaauc 20
<210> 1422
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1422
aaaccucuac cucucuaaac 20
<210> 1423
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1423
aaacucacag gcagcccaaa 20
<210> 1424
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1424
aaacuccaau uccaccauac 20
<210> 1425
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1425
aaacuccaau uccacgauac 20
<210> 1426
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1426
aaacuccaau uccaugauac 20
<210> 1427
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1427
aaacucccaa aucuuguaaa 20
<210> 1428
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1428
aaacucccgg acacccucaa 20
<210> 1429
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1429
aaacucucag gcagcccaaa 20
<210> 1430
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1430
aaagauuggc uacuucgggu 20
<210> 1431
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1431
aaagccuggg caacgagggg 20
<210> 1432
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1432
aaaggccagg cccagcuggc 20
<210> 1433
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1433
aaauacaauc aauuccaaau 20
<210> 1434
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1434
aaauauguaa acacucaaac 20
<210> 1435
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1435
aaaucuuaga gcaccccaaa 20
<210> 1436
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1436
aaaucuugua aaguccaaac 20
<210> 1437
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1437
aaaugcaccc ugaauucuac 20
<210> 1438
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1438
aaaugcccca acuauacaug 20
<210> 1439
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1439
aaauguauau aaacuccaau 20
<210> 1440
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1440
aaaugucugc uuccacccca 20
<210> 1441
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1441
aaauugcaag uccccaagcu 20
<210> 1442
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1442
aacaccacau acacccuaaa 20
<210> 1443
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1443
aacacccaaa cucucaggca 20
<210> 1444
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1444
aacacccaaa ugcacccuga 20
<210> 1445
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1445
aacacccaac ccauaaacac 20
<210> 1446
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1446
aacaccccag uccuaauaaa 20
<210> 1447
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1447
aacacucaaa cucccggaca 20
<210> 1448
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1448
aacacuccaa auauguaaac 20
<210> 1449
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1449
aacagaugac cucaauucua 20
<210> 1450
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1450
aacagggcug guucuggggu 20
<210> 1451
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1451
aacaucccaa acuccaauuc 20
<210> 1452
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1452
aaccaacaga ugaccucaau 20
<210> 1453
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1453
aaccacaugg gcaggacagc 20
<210> 1454
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1454
aaccagcccu guuugugggu 20
<210> 1455
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1455
aaccagcguc agcaacuccu 20
<210> 1456
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1456
aacccacaca ugccccaaac 20
<210> 1457
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1457
aacccacacu gaaaauugca 20
<210> 1458
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1458
aacccacaua cgccaaaacc 20
<210> 1459
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1459
aacccagccu aaaccuccaa 20
<210> 1460
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1460
aacccauaaa cacccaaacu 20
<210> 1461
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1461
aaccccugaa uccacaaaca 20
<210> 1462
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1462
aacccgaagu agccaaucuu 20
<210> 1463
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1463
aacccuaaac cucuaccucu 20
<210> 1464
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1464
aacccugaac cuuccaacca 20
<210> 1465
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1465
aaccgcacca ucaaugaaca 20
<210> 1466
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1466
aaccucaaau cuuagagcac 20
<210> 1467
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1467
aaccuccaac accccagucc 20
<210> 1468
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1468
aaccucuaaa ccucaaaucu 20
<210> 1469
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1469
aaccucuacc ucucuaaaca 20
<210> 1470
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1470
aaccugcuaa ccccugaauc 20
<210> 1471
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1471
aaccuuccaa ccagcgucag 20
<210> 1472
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1472
aacgaggggg ccacacaucc 20
<210> 1473
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1473
aacuauacau gaacccgaag 20
<210> 1474
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1474
aacucacagg cagcccaaau 20
<210> 1475
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1475
aacuccaauu ccaccauacc 20
<210> 1476
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1476
aacuccaauu ccacgauacc 20
<210> 1477
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1477
aacuccaauu ccaugauacc 20
<210> 1478
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1478
aacucccaaa ucuuguaaag 20
<210> 1479
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1479
aacucccgga cacccucaac 20
<210> 1480
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1480
aacuccucca agucucugga 20
<210> 1481
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1481
aacucuaccu acccaaaccc 20
<210> 1482
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1482
aacucucagg cagcccaaau 20
<210> 1483
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1483
aagauaaugg cauuggcaag 20
<210> 1484
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1484
aagauuggcu acuucggguu 20
<210> 1485
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1485
aagauuugag guuuagaggu 20
<210> 1486
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1486
aagauuuggg aguuugcagc 20
<210> 1487
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1487
aagcagacau uugggggucc 20
<210> 1488
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1488
aagcccacuc ccgugcccca 20
<210> 1489
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1489
aagccugggc aacgaggggg 20
<210> 1490
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1490
aagcugcaaa cucccaaauc 20
<210> 1491
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1491
aaggccaggc ccagcuggcu 20
<210> 1492
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1492
aagguucagg guuugguggg 20
<210> 1493
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1493
aaguagccaa ucuuuaaacc 20
<210> 1494
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1494
aaguccagag acuuggagga 20
<210> 1495
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1495
aaguccccaa gcugcaaacu 20
<210> 1496
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1496
aagucucugg acuuccagac 20
<210> 1497
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1497
aagugcgccg gcagucacug 20
<210> 1498
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1498
aauacaauca auuccaaaug 20
<210> 1499
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1499
aauauauaua aucauuccca 20
<210> 1500
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1500
aauauguaaa cacucaaacu 20
<210> 1501
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1501
aaucaauucc aaaugcccca 20
<210> 1502
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1502
aaucauuccc aaccugcuaa 20
<210> 1503
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1503
aauccacaaa cacccaaaug 20
<210> 1504
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1504
aauccaggua ucauggaauu 20
<210> 1505
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1505
aauccaggua ucguggaauu 20
<210> 1506
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1506
aauccaggua ugguggaauu 20
<210> 1507
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1507
aaucgccuaa acccacacau 20
<210> 1508
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1508
aaucuuagag caccccaaac 20
<210> 1509
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1509
aaucuuguaa aguccaaacc 20
<210> 1510
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1510
aaucuuuaaa cccacacuga 20
<210> 1511
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1511
aaugaacacc acauacaccc 20
<210> 1512
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1512
aaugacaagc ccacucccgu 20
<210> 1513
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1513
aaugauuaua uauauuuggg 20
<210> 1514
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1514
aaugcacccu gaauucuaca 20
<210> 1515
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1515
aaugccauua ucuucucugg 20
<210> 1516
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1516
aaugccccaa cuauacauga 20
<210> 1517
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1517
aauggcauug gcaagugcgc 20
<210> 1518
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1518
aauguauaua aacuccaauu 20
<210> 1519
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1519
aaugucugcu uccaccccag 20
<210> 1520
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1520
aauucagggu gcauuugggu 20
<210> 1521
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1521
aauuccaaau gccccaacua 20
<210> 1522
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1522
aauuccacca uaccuggauu 20
<210> 1523
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1523
aauuccacga uaccuggauu 20
<210> 1524
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1524
aauuccauga uaccuggauu 20
<210> 1525
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1525
aauucuacag ggaccuggac 20
<210> 1526
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1526
aauucuagaa acaucccaaa 20
<210> 1527
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1527
aauugagguc aucuguuggu 20
<210> 1528
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1528
aauugauugu auuuauuagg 20
<210> 1529
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1529
aauugcaagu ccccaagcug 20
<210> 1530
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1530
aauuggaguu ugggauguuu 20
<210> 1531
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1531
aauuuucagu guggguuuaa 20
<210> 1532
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1532
acaaacaccc aaaugcaccc 20
<210> 1533
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1533
acaaacaccc aacccauaaa 20
<210> 1534
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1534
acaaacaggg cugguucugg 20
<210> 1535
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1535
acaagauuug ggaguuugca 20
<210> 1536
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1536
acaagcccac ucccgugccc 20
<210> 1537
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1537
acaaucaauu ccaaaugccc 20
<210> 1538
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1538
acaaucgccu aaacccacac 20
<210> 1539
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1539
acacagccug ccaggcgcug 20
<210> 1540
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1540
acacauccca ccaaacccug 20
<210> 1541
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1541
acacaugccc caaacccuaa 20
<210> 1542
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1542
acaccacaua cacccuaaac 20
<210> 1543
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1543
acacccaaac ucucaggcag 20
<210> 1544
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1544
acacccaaau gcacccugaa 20
<210> 1545
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1545
acacccaacc cauaaacacc 20
<210> 1546
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1546
acaccccagu ccuaauaaau 20
<210> 1547
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1547
acacccuaaa ccaacagaug 20
<210> 1548
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1548
acacccucaa cucuaccuac 20
<210> 1549
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1549
acacucaaac ucccggacac 20
<210> 1550
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1550
acacuccaaa uauguaaaca 20
<210> 1551
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1551
acacugaaaa uugcaagucc 20
<210> 1552
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1552
acagaugacc ucaauucuag 20
<210> 1553
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1553
acagcagcca ccaugacucc 20
<210> 1554
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1554
acagccugcc aggcgcugac 20
<210> 1555
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1555
acaggcagcc caaauauaua 20
<210> 1556
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1556
acaggcagcc caaauguaua 20
<210> 1557
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1557
acagggaccu ggacccccaa 20
<210> 1558
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1558
acagggcugg uucuggggug 20
<210> 1559
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1559
acauacaccc uaaaccaaca 20
<210> 1560
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1560
acauacgcca aaaccucuaa 20
<210> 1561
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1561
acauauuugg aguguuuaga 20
<210> 1562
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1562
acaucccaaa cuccaauucc 20
<210> 1563
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1563
acaucccacc aaacccugaa 20
<210> 1564
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1564
acauccgugg aaugacaagc 20
<210> 1565
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1565
acaugaaccc gaaguagcca 20
<210> 1566
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1566
acaugcccca aacccuaaac 20
<210> 1567
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1567
acaugggcag gacagcagcc 20
<210> 1568
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1568
acauuugggc ugccugagag 20
<210> 1569
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1569
acauuugggc ugccugugag 20
<210> 1570
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1570
acauuugggg guccaggucc 20
<210> 1571
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1571
accaaacccu gaaccuucca 20
<210> 1572
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1572
accaacagau gaccucaauu 20
<210> 1573
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1573
accacauaca cccuaaacca 20
<210> 1574
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1574
accacauggg caggacagca 20
<210> 1575
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1575
accagaggcu ggggcacaca 20
<210> 1576
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1576
accagcccug uuugugggua 20
<210> 1577
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1577
accagcguca gcaacuccuc 20
<210> 1578
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1578
accauaccug gauuccacaa 20
<210> 1579
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1579
accaucaaug aacaccacau 20
<210> 1580
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1580
accaugacuc ccacucucag 20
<210> 1581
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1581
acccaaaccc acauacgcca 20
<210> 1582
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1582
acccaaacuc acaggcagcc 20
<210> 1583
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1583
acccaaacuc ucaggcagcc 20
<210> 1584
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1584
acccaaaugc acccugaauu 20
<210> 1585
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1585
acccaaccca uaaacaccca 20
<210> 1586
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1586
acccacaaac agggcugguu 20
<210> 1587
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1587
acccacaauc gccuaaaccc 20
<210> 1588
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1588
acccacacau gccccaaacc 20
<210> 1589
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1589
acccacacug aaaauugcaa 20
<210> 1590
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1590
acccacauac gccaaaaccu 20
<210> 1591
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1591
acccagccua aaccuccaac 20
<210> 1592
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1592
acccauaaac acccaaacuc 20
<210> 1593
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1593
accccaaacc cagccuaaac 20
<210> 1594
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1594
accccagaac cagcccuguu 20
<210> 1595
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1595
accccagucc uaauaaauac 20
<210> 1596
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1596
acccccaaau gucugcuucc 20
<210> 1597
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1597
acccccaacc gcaccaucaa 20
<210> 1598
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1598
accccugaau ccacaaacac 20
<210> 1599
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1599
acccgaagua gccaaucuuu 20
<210> 1600
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1600
acccuaaacc aacagaugac 20
<210> 1601
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1601
acccuaaacc ucuaccucuc 20
<210> 1602
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1602
acccucaacu cuaccuaccc 20
<210> 1603
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1603
acccugaacc uuccaaccag 20
<210> 1604
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1604
acccugaauu cuacagggac 20
<210> 1605
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1605
accgcaccau caaugaacac 20
<210> 1606
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1606
accgucucaa ccacaugggc 20
<210> 1607
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1607
accuacccaa acccacauac 20
<210> 1608
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1608
accucaaauc uuagagcacc 20
<210> 1609
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1609
accucaauuc uagaaacauc 20
<210> 1610
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1610
accuccaaca ccccaguccu 20
<210> 1611
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1611
accucuaaac cucaaaucuu 20
<210> 1612
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1612
accucuaccu cucuaaacac 20
<210> 1613
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1613
accucucuaa acacuccaaa 20
<210> 1614
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1614
accugcuaac cccugaaucc 20
<210> 1615
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1615
accuggaccc ccaaaugucu 20
<210> 1616
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1616
accuggauuc cacaaacacc 20
<210> 1617
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1617
accuuccaac cagcgucagc 20
<210> 1618
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1618
acgagggggc cacacauccc 20
<210> 1619
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1619
acgauaccug gauuccacaa 20
<210> 1620
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1620
acgccaaaac cucuaaaccu 20
<210> 1621
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1621
acgccagucc ucacuggagu 20
<210> 1622
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1622
acgcugguug gaagguucag 20
<210> 1623
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1623
acggauguga gacgccaguc 20
<210> 1624
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1624
acgggagugg gcuugucauu 20
<210> 1625
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1625
acgguggcag ugcccagaga 20
<210> 1626
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1626
acuauacaug aacccgaagu 20
<210> 1627
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1627
acucaaacuc ccggacaccc 20
<210> 1628
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1628
acucacaggc agcccaaaua 20
<210> 1629
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1629
acucacaggc agcccaaaug 20
<210> 1630
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1630
acuccaaaua uguaaacacu 20
<210> 1631
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1631
acuccaauuc caccauaccu 20
<210> 1632
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1632
acuccaauuc cacgauaccu 20
<210> 1633
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1633
acuccaauuc caugauaccu 20
<210> 1634
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1634
acuccaguga ggacuggcgu 20
<210> 1635
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1635
acucccaaau cuuguaaagu 20
<210> 1636
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1636
acucccacuc ucagccagcu 20
<210> 1637
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1637
acucccggac acccucaacu 20
<210> 1638
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1638
acuccuccaa gucucuggac 20
<210> 1639
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1639
acucggaggu uuggacuuua 20
<210> 1640
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1640
acucuaccca caaacagggc 20
<210> 1641
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1641
acucuaccua cccaaaccca 20
<210> 1642
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1642
acucucagcc agcugggccu 20
<210> 1643
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1643
acucucaggc agcccaaaug 20
<210> 1644
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1644
acugaaaauu gcaagucccc 20
<210> 1645
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1645
acugccaccg ucucaaccac 20
<210> 1646
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1646
acugccggcg cacuugccaa 20
<210> 1647
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1647
acuggaguca gcgccuggca 20
<210> 1648
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1648
acuggauccu cuccaggacc 20
<210> 1649
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1649
acuggcgucu cacauccgug 20
<210> 1650
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1650
acuggggugu uggagguuua 20
<210> 1651
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1651
acuuccagac ccacaaucgc 20
<210> 1652
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1652
acuucggguu cauguauagu 20
<210> 1653
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1653
acuugcaauu uucagugugg 20
<210> 1654
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1654
acuugccaau gccauuaucu 20
<210> 1655
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1655
acuuggagga guugcugacg 20
<210> 1656
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1656
acuuuacaag auuugggagu 20
<210> 1657
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1657
agaaacaucc caaacuccaa 20
<210> 1658
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1658
agaaccagcc cuguuugugg 20
<210> 1659
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1659
agaagauaau ggcauuggca 20
<210> 1660
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1660
agaauucagg gugcauuugg 20
<210> 1661
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1661
agaauugagg ucaucuguug 20
<210> 1662
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1662
agacauuugg ggguccaggu 20
<210> 1663
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1663
agacccacaa ucgccuaaac 20
<210> 1664
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1664
agacgccagu ccucacugga 20
<210> 1665
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1665
agacgguggc agugcccaga 20
<210> 1666
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1666
agacucggag guuuggacuu 20
<210> 1667
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1667
agacuuggag gaguugcuga 20
<210> 1668
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1668
agagaagaua auggcauugg 20
<210> 1669
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1669
agagacuugg aggaguugcu 20
<210> 1670
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1670
agagagguag agguuuaggg 20
<210> 1671
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1671
agagcacccc aaacccagcc 20
<210> 1672
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1672
agaggaucca gugacugccg 20
<210> 1673
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1673
agaggcuggg gcacacagcc 20
<210> 1674
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1674
agagguagag guuuaggguu 20
<210> 1675
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1675
agagguuuag gguuuggggc 20
<210> 1676
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1676
agagguuuug gcguaugugg 20
<210> 1677
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1677
agagugggag ucaugguggc 20
<210> 1678
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1678
agaguugagg guguccggga 20
<210> 1679
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1679
agaguuuggg uguuuauggg 20
<210> 1680
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1680
agauaauggc auuggcaagu 20
<210> 1681
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1681
agaugaccuc aauucuagaa 20
<210> 1682
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1682
agauuggcua cuucggguuc 20
<210> 1683
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1683
agauuugagg uuuagagguu 20
<210> 1684
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1684
agauuuggga guuugcagcu 20
<210> 1685
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1685
agcaacuccu ccaagucucu 20
<210> 1686
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1686
agcaccccaa acccagccua 20
<210> 1687
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1687
agcagacauu ugggggucca 20
<210> 1688
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1688
agcagccacc augacuccca 20
<210> 1689
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1689
agcagguugg gaaugauuau 20
<210> 1690
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1690
agccaaucuu uaaacccaca 20
<210> 1691
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1691
agccaccaug acucccacuc 20
<210> 1692
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1692
agccagcugg gccuggccuu 20
<210> 1693
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1693
agcccaaaua uauauaauca 20
<210> 1694
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1694
agcccacucc cgugccccac 20
<210> 1695
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1695
agcccuguuu guggguagag 20
<210> 1696
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1696
agccuaaacc uccaacaccc 20
<210> 1697
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1697
agccucuggu ccuggagagg 20
<210> 1698
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1698
agccugccag gcgcugacuc 20
<210> 1699
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1699
agccugggca acgagggggc 20
<210> 1700
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1700
agcgccuggc aggcugugug 20
<210> 1701
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1701
agcgucagca acuccuccaa 20
<210> 1702
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1702
agcugcaaac ucccaaaucu 20
<210> 1703
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1703
agcuggcuga gagugggagu 20
<210> 1704
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1704
agcugggccu ggccuuugaa 20
<210> 1705
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1705
agcuugggga cuugcaauuu 20
<210> 1706
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1706
aggacagcag ccaccaugac 20
<210> 1707
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1707
aggaccagag gcuggggcac 20
<210> 1708
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1708
aggacuggcg ucucacaucc 20
<210> 1709
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1709
aggacugggg uguuggaggu 20
<210> 1710
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1710
aggaguugcu gacgcugguu 20
<210> 1711
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1711
aggauccagu gacugccggc 20
<210> 1712
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1712
aggcagccca aauauauaua 20
<210> 1713
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1713
aggccaggcc cagcuggcug 20
<210> 1714
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1714
aggcccagcu ggcugagagu 20
<210> 1715
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1715
aggcgauugu gggucuggaa 20
<210> 1716
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1716
aggcgcugac uccagugagg 20
<210> 1717
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1717
aggcuggggc acacagccug 20
<210> 1718
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1718
aggcuggguu uggggugcuc 20
<210> 1719
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1719
aggcugugug ccccagccuc 20
<210> 1720
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1720
aggcuuucaa aggccaggcc 20
<210> 1721
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1721
agggaccugg acccccaaau 20
<210> 1722
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1722
agggcugguu cuggggugga 20
<210> 1723
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1723
agggggccac acaucccacc 20
<210> 1724
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1724
agggguuagc agguugggaa 20
<210> 1725
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1725
agggugcauu uggguguuug 20
<210> 1726
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1726
aggguguaug ugguguucau 20
<210> 1727
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1727
aggguguccg ggaguuugag 20
<210> 1728
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1728
aggguuuggg gcaugugugg 20
<210> 1729
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1729
aggguuuggu gggaugugug 20
<210> 1730
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1730
agguagaggu uuaggguuug 20
<210> 1731
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1731
agguagaguu gagggugucc 20
<210> 1732
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1732
agguaucaug gaauuggagu 20
<210> 1733
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1733
agguaucgug gaauuggagu 20
<210> 1734
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1734
agguauggug gaauuggagu 20
<210> 1735
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1735
aggucaucug uugguuuagg 20
<210> 1736
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1736
aggucccugu agaauucagg 20
<210> 1737
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1737
agguucaggg uuugguggga 20
<210> 1738
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1738
agguuuagag guuuuggcgu 20
<210> 1739
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1739
agguuuaggc uggguuuggg 20
<210> 1740
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1740
agguuuaggg uuuggggcau 20
<210> 1741
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1741
agguuuggac uuuacaagau 20
<210> 1742
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1742
agguuuuggc guaugugggu 20
<210> 1743
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1743
aguagccaau cuuuaaaccc 20
<210> 1744
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1744
agucacugga uccucuccag 20
<210> 1745
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1745
agucagcgcc uggcaggcug 20
<210> 1746
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1746
agucauggug gcugcugucc 20
<210> 1747
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1747
aguccagaga cuuggaggag 20
<210> 1748
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1748
aguccccaag cugcaaacuc 20
<210> 1749
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1749
aguccucacu ggagucagcg 20
<210> 1750
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1750
agucucugga cuuccagacc 20
<210> 1751
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1751
agugacugcc ggcgcacuug 20
<210> 1752
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1752
agugaggacu ggcgucucac 20
<210> 1753
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1753
agugcccaga gaagauaaug 20
<210> 1754
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1754
agugcgccgg cagucacugg 20
<210> 1755
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1755
agugggaguc augguggcug 20
<210> 1756
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1756
agugggcuug ucauuccacg 20
<210> 1757
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1757
aguggggcac gggagugggc 20
<210> 1758
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1758
agugguuaug acucuaccca 20
<210> 1759
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1759
aguguggguu uaaagauugg 20
<210> 1760
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1760
aguguuuaca uauuuggagu 20
<210> 1761
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1761
aguguuuaga gagguagagg 20
<210> 1762
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1762
aguugagggu guccgggagu 20
<210> 1763
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1763
aguugcugac gcugguugga 20
<210> 1764
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1764
aguuggggca uuuggaauug 20
<210> 1765
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1765
aguuuauaua cauuugggcu 20
<210> 1766
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1766
aguuugagug uuuacauauu 20
<210> 1767
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1767
aguuugcagc uuggggacuu 20
<210> 1768
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1768
aguuugggau guuucuagaa 20
<210> 1769
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1769
aguuugggug uuuauggguu 20
<210> 1770
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1770
auaaacaccc aaacucucag 20
<210> 1771
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1771
auaaacucca auuccacgau 20
<210> 1772
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1772
auaaacucca auuccaugau 20
<210> 1773
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1773
auaaauacaa ucaauuccaa 20
<210> 1774
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1774
auaaucauuc ccaaccugcu 20
<210> 1775
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1775
auaauggcau uggcaagugc 20
<210> 1776
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1776
auacaaucaa uuccaaaugc 20
<210> 1777
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1777
auacacccua aaccaacaga 20
<210> 1778
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1778
auacaugaac ccgaaguagc 20
<210> 1779
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1779
auacauuugg gcugccugag 20
<210> 1780
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1780
auacauuugg gcugccugug 20
<210> 1781
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1781
auacgccaaa accucuaaac 20
<210> 1782
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1782
auaguugggg cauuuggaau 20
<210> 1783
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1783
auauaaacuc caauuccacg 20
<210> 1784
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1784
auauaaacuc caauuccaug 20
<210> 1785
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1785
auauaaucau ucccaaccug 20
<210> 1786
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1786
auauacauuu gggcugccug 20
<210> 1787
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1787
auauauaauc auucccaacc 20
<210> 1788
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1788
auauauauaa ucauucccaa 20
<210> 1789
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1789
auauauauuu gggcugccug 20
<210> 1790
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1790
auauauuugg gcugccugug 20
<210> 1791
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1791
auauguaaac acucaaacuc 20
<210> 1792
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1792
auauuuggag uguuuagaga 20
<210> 1793
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1793
auauuugggc ugccugugag 20
<210> 1794
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1794
aucaaugaac accacauaca 20
<210> 1795
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1795
aucaauucca aaugccccaa 20
<210> 1796
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1796
aucauuccca accugcuaac 20
<210> 1797
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1797
auccacaaac acccaaaugc 20
<210> 1798
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1798
auccagguau cauggaauug 20
<210> 1799
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1799
auccagguau cguggaauug 20
<210> 1800
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1800
auccagguau gguggaauug 20
<210> 1801
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1801
auccagugac ugccggcgca 20
<210> 1802
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1802
aucccaaacu ccaauuccac 20
<210> 1803
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1803
aucccaccaa acccugaacc 20
<210> 1804
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1804
auccguggaa ugacaagccc 20
<210> 1805
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1805
auccucucca ggaccagagg 20
<210> 1806
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1806
aucgccuaaa cccacacaug 20
<210> 1807
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1807
aucguggaau uggaguuuau 20
<210> 1808
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1808
aucuguuggu uuagggugua 20
<210> 1809
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1809
aucuuagagc accccaaacc 20
<210> 1810
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1810
aucuucucug ggcacugcca 20
<210> 1811
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1811
aucuuguaaa guccaaaccu 20
<210> 1812
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1812
aucuuuaaac ccacacugaa 20
<210> 1813
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1813
augaacacca cauacacccu 20
<210> 1814
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1814
augaacccga aguagccaau 20
<210> 1815
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1815
augacaagcc cacucccgug 20
<210> 1816
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1816
augaccucaa uucuagaaac 20
<210> 1817
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1817
augacuccca cucucagcca 20
<210> 1818
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1818
augacucuac ccacaaacag 20
<210> 1819
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1819
augauaccug gauuccacaa 20
<210> 1820
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1820
augauuauau auauuugggc 20
<210> 1821
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1821
augcacccug aauucuacag 20
<210> 1822
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1822
augccauuau cuucucuggg 20
<210> 1823
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1823
augccccaaa cccuaaaccu 20
<210> 1824
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1824
augccccaac uauacaugaa 20
<210> 1825
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1825
auggcauugg caagugcgcc 20
<210> 1826
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1826
augggcagga cagcagccac 20
<210> 1827
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1827
auggguuggg uguuugugga 20
<210> 1828
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1828
augguggaau uggaguuugg 20
<210> 1829
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1829
augguggcug cuguccugcc 20
<210> 1830
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1830
auguaaacac ucaaacuccc 20
<210> 1831
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1831
auguauaguu ggggcauuug 20
<210> 1832
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1832
auguauauaa acuccaauuc 20
<210> 1833
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1833
augucugcuu ccaccccaga 20
<210> 1834
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1834
augugagacg ccaguccuca 20
<210> 1835
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1835
auguggguuu ggguagguag 20
<210> 1836
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1836
augugguguu cauugauggu 20
<210> 1837
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1837
augugguuga gacgguggca 20
<210> 1838
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1838
auguguggcc cccucguugc 20
<210> 1839
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1839
augugugggu uuaggcgauu 20
<210> 1840
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1840
auguuucuag aauugagguc 20
<210> 1841
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1841
auuaggacug ggguguugga 20
<210> 1842
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1842
auuauauaua uuugggcugc 20
<210> 1843
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1843
auuaucuucu cugggcacug 20
<210> 1844
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1844
auucaggggu uagcagguug 20
<210> 1845
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1845
auucagggug cauuugggug 20
<210> 1846
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1846
auuccaaaug ccccaacuau 20
<210> 1847
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1847
auuccacaaa cacccaaccc 20
<210> 1848
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1848
auuccaccau accuggauuc 20
<210> 1849
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1849
auuccacgau accuggauuc 20
<210> 1850
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1850
auuccacgga ugugagacgc 20
<210> 1851
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1851
auuccaugau accuggauuc 20
<210> 1852
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1852
auucccaacc ugcuaacccc 20
<210> 1853
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1853
auucuacagg gaccuggacc 20
<210> 1854
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1854
auucuagaaa caucccaaac 20
<210> 1855
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1855
auugagguca ucuguugguu 20
<210> 1856
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1856
auugauugua uuuauuagga 20
<210> 1857
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1857
auugcaaguc cccaagcugc 20
<210> 1858
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1858
auuggaguuu gggauguuuc 20
<210> 1859
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1859
auuggcaagu gcgccggcag 20
<210> 1860
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1860
auuggcuacu ucggguucau 20
<210> 1861
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1861
auuguauuua uuaggacugg 20
<210> 1862
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1862
auuguggguc uggaagucca 20
<210> 1863
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1863
auuuauuagg acuggggugu 20
<210> 1864
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1864
auuugagguu uagagguuuu 20
<210> 1865
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1865
auuuggagug uuuagagagg 20
<210> 1866
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1866
auuugggagu uugcagcuug 20
<210> 1867
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1867
auuugggcug ccugagaguu 20
<210> 1868
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1868
auuugggggu ccaggucccu 20
<210> 1869
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1869
auuugggugu uuguggauuc 20
<210> 1870
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1870
auuuucagug uggguuuaaa 20
<210> 1871
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1871
caaaaccucu aaaccucaaa 20
<210> 1872
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1872
caaacaccca aaugcacccu 20
<210> 1873
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1873
caaacaccca acccauaaac 20
<210> 1874
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1874
caaacagggc ugguucuggg 20
<210> 1875
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1875
caaacccaca uacgccaaaa 20
<210> 1876
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1876
caaacccagc cuaaaccucc 20
<210> 1877
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1877
caaacccuaa accucuaccu 20
<210> 1878
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1878
caaacccuga accuuccaac 20
<210> 1879
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1879
caaacucaca ggcagcccaa 20
<210> 1880
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1880
caaacuccaa uuccaccaua 20
<210> 1881
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1881
caaacuccca aaucuuguaa 20
<210> 1882
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1882
caaacucccg gacacccuca 20
<210> 1883
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1883
caaacucuca ggcagcccaa 20
<210> 1884
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1884
caaaggccag gcccagcugg 20
<210> 1885
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1885
caaauaugua aacacucaaa 20
<210> 1886
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1886
caaaucuuag agcaccccaa 20
<210> 1887
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1887
caaaucuugu aaaguccaaa 20
<210> 1888
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1888
caaaugcacc cugaauucua 20
<210> 1889
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1889
caaaugcccc aacuauacau 20
<210> 1890
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1890
caaauguaua uaaacuccaa 20
<210> 1891
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1891
caaaugucug cuuccacccc 20
<210> 1892
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1892
caacacccca guccuaauaa 20
<210> 1893
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1893
caacagauga ccucaauucu 20
<210> 1894
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1894
caaccacaug ggcaggacag 20
<210> 1895
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1895
caaccagcgu cagcaacucc 20
<210> 1896
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1896
caacccauaa acacccaaac 20
<210> 1897
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1897
caaccgcacc aucaaugaac 20
<210> 1898
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1898
caaccugcua accccugaau 20
<210> 1899
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1899
caacgagggg gccacacauc 20
<210> 1900
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1900
caacuauaca ugaacccgaa 20
<210> 1901
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1901
caacuccucc aagucucugg 20
<210> 1902
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1902
caacucuacc uacccaaacc 20
<210> 1903
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1903
caagauuugg gaguuugcag 20
<210> 1904
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1904
caagcccacu cccgugcccc 20
<210> 1905
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1905
caagcugcaa acucccaaau 20
<210> 1906
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1906
caagucccca agcugcaaac 20
<210> 1907
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1907
caagucucug gacuuccaga 20
<210> 1908
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1908
caagugcgcc ggcagucacu 20
<210> 1909
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1909
caaucaauuc caaaugcccc 20
<210> 1910
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1910
caaucgccua aacccacaca 20
<210> 1911
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1911
caaucuuuaa acccacacug 20
<210> 1912
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1912
caaugaacac cacauacacc 20
<210> 1913
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1913
caaugccauu aucuucucug 20
<210> 1914
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1914
caauuccaaa ugccccaacu 20
<210> 1915
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1915
caauuccacc auaccuggau 20
<210> 1916
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1916
caauuccacg auaccuggau 20
<210> 1917
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1917
caauuccaug auaccuggau 20
<210> 1918
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1918
caauucuaga aacaucccaa 20
<210> 1919
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1919
caauuuucag uguggguuua 20
<210> 1920
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1920
cacaaacacc caaaugcacc 20
<210> 1921
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1921
cacaaacacc caacccauaa 20
<210> 1922
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1922
cacaaacagg gcugguucug 20
<210> 1923
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1923
cacaaucgcc uaaacccaca 20
<210> 1924
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1924
cacacagccu gccaggcgcu 20
<210> 1925
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1925
cacacauccc accaaacccu 20
<210> 1926
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1926
cacacaugcc ccaaacccua 20
<210> 1927
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1927
cacacugaaa auugcaaguc 20
<210> 1928
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1928
cacagccugc caggcgcuga 20
<210> 1929
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1929
cacaggcagc ccaaauauau 20
<210> 1930
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1930
cacaggcagc ccaaauguau 20
<210> 1931
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1931
cacauacacc cuaaaccaac 20
<210> 1932
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1932
cacauacgcc aaaaccucua 20
<210> 1933
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1933
cacaucccac caaacccuga 20
<210> 1934
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1934
cacauccgug gaaugacaag 20
<210> 1935
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1935
cacaugcccc aaacccuaaa 20
<210> 1936
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1936
cacaugggca ggacagcagc 20
<210> 1937
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1937
caccaaaccc ugaaccuucc 20
<210> 1938
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1938
caccacauac acccuaaacc 20
<210> 1939
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1939
caccauaccu ggauuccaca 20
<210> 1940
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1940
caccaucaau gaacaccaca 20
<210> 1941
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1941
caccaugacu cccacucuca 20
<210> 1942
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1942
cacccaaacu cucaggcagc 20
<210> 1943
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1943
cacccaaaug cacccugaau 20
<210> 1944
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1944
cacccaaccc auaaacaccc 20
<210> 1945
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1945
caccccaaac ccagccuaaa 20
<210> 1946
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1946
caccccagaa ccagcccugu 20
<210> 1947
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1947
caccccaguc cuaauaaaua 20
<210> 1948
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1948
cacccuaaac caacagauga 20
<210> 1949
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1949
cacccucaac ucuaccuacc 20
<210> 1950
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1950
cacccugaau ucuacaggga 20
<210> 1951
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1951
caccgucuca accacauggg 20
<210> 1952
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1952
cacgauaccu ggauuccaca 20
<210> 1953
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1953
cacggaugug agacgccagu 20
<210> 1954
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1954
cacgggagug ggcuugucau 20
<210> 1955
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1955
cacucaaacu cccggacacc 20
<210> 1956
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1956
cacuccaaau auguaaacac 20
<210> 1957
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1957
cacucucagc cagcugggcc 20
<210> 1958
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1958
cacugaaaau ugcaaguccc 20
<210> 1959
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1959
cacugccacc gucucaacca 20
<210> 1960
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1960
cacuggaguc agcgccuggc 20
<210> 1961
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1961
cacuggaucc ucuccaggac 20
<210> 1962
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1962
cacuugccaa ugccauuauc 20
<210> 1963
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1963
cagaaccagc ccuguuugug 20
<210> 1964
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1964
cagacauuug gggguccagg 20
<210> 1965
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1965
cagacccaca aucgccuaaa 20
<210> 1966
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1966
cagagaagau aauggcauug 20
<210> 1967
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1967
cagagacuug gaggaguugc 20
<210> 1968
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1968
cagaggcugg ggcacacagc 20
<210> 1969
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1969
cagaugaccu caauucuaga 20
<210> 1970
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1970
cagcaacucc uccaagucuc 20
<210> 1971
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1971
cagcagccac caugacuccc 20
<210> 1972
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1972
cagccaccau gacucccacu 20
<210> 1973
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1973
cagccagcug ggccuggccu 20
<210> 1974
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1974
cagcccaaau auauauaauc 20
<210> 1975
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1975
cagcccuguu uguggguaga 20
<210> 1976
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1976
cagccuaaac cuccaacacc 20
<210> 1977
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1977
cagccucugg uccuggagag 20
<210> 1978
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1978
cagccugcca ggcgcugacu 20
<210> 1979
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1979
cagcgccugg caggcugugu 20
<210> 1980
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1980
cagcgucagc aacuccucca 20
<210> 1981
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1981
cagcuggcug agagugggag 20
<210> 1982
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1982
cagcugggcc uggccuuuga 20
<210> 1983
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1983
cagcuugggg acuugcaauu 20
<210> 1984
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1984
caggacagca gccaccauga 20
<210> 1985
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1985
caggaccaga ggcuggggca 20
<210> 1986
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1986
caggcagccc aaauauauau 20
<210> 1987
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1987
caggcccagc uggcugagag 20
<210> 1988
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1988
caggcgcuga cuccagugag 20
<210> 1989
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1989
caggcugugu gccccagccu 20
<210> 1990
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1990
caggcuuuca aaggccaggc 20
<210> 1991
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1991
cagggaccug gacccccaaa 20
<210> 1992
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1992
cagggcuggu ucuggggugg 20
<210> 1993
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1993
cagggguuag cagguuggga 20
<210> 1994
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1994
cagggugcau uuggguguuu 20
<210> 1995
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1995
caggguuugg ugggaugugu 20
<210> 1996
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1996
cagguaucau ggaauuggag 20
<210> 1997
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1997
cagguaucgu ggaauuggag 20
<210> 1998
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1998
cagguauggu ggaauuggag 20
<210> 1999
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 1999
caggucccug uagaauucag 20
<210> 2000
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2000
cagucacugg auccucucca 20
<210> 2001
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2001
caguccuaau aaauacaauc 20
<210> 2002
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2002
caguccucac uggagucagc 20
<210> 2003
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2003
cagugacugc cggcgcacuu 20
<210> 2004
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2004
cagugaggac uggcgucuca 20
<210> 2005
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2005
cagugcccag agaagauaau 20
<210> 2006
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2006
cagugugggu uuaaagauug 20
<210> 2007
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2007
cauaaacacc caaacucuca 20
<210> 2008
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2008
cauacacccu aaaccaacag 20
<210> 2009
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2009
cauaccugga uuccacaaac 20
<210> 2010
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2010
cauacgccaa aaccucuaaa 20
<210> 2011
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2011
cauauuugga guguuuagag 20
<210> 2012
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2012
caucaaugaa caccacauac 20
<210> 2013
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2013
caucccaaac uccaauucca 20
<210> 2014
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2014
caucccacca aacccugaac 20
<210> 2015
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2015
cauccgugga augacaagcc 20
<210> 2016
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2016
caucuguugg uuuagggugu 20
<210> 2017
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2017
caugaacccg aaguagccaa 20
<210> 2018
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2018
caugacuccc acucucagcc 20
<210> 2019
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2019
caugauaccu ggauuccaca 20
<210> 2020
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2020
caugccccaa acccuaaacc 20
<210> 2021
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2021
caugggcagg acagcagcca 20
<210> 2022
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2022
caugguggcu gcuguccugc 20
<210> 2023
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2023
cauguauagu uggggcauuu 20
<210> 2024
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2024
caugugguug agacgguggc 20
<210> 2025
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2025
cauguguggg uuuaggcgau 20
<210> 2026
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2026
cauuaucuuc ucugggcacu 20
<210> 2027
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2027
cauuccacgg augugagacg 20
<210> 2028
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2028
cauucccaac cugcuaaccc 20
<210> 2029
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2029
cauuggcaag ugcgccggca 20
<210> 2030
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2030
cauuugggcu gccugagagu 20
<210> 2031
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2031
cauuugggcu gccugugagu 20
<210> 2032
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2032
cauuuggggg uccagguccc 20
<210> 2033
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2033
cauuugggug uuuguggauu 20
<210> 2034
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2034
ccaaaaccuc uaaaccucaa 20
<210> 2035
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2035
ccaaacccac auacgccaaa 20
<210> 2036
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2036
ccaaacccag ccuaaaccuc 20
<210> 2037
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2037
ccaaacccua aaccucuacc 20
<210> 2038
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2038
ccaaacccug aaccuuccaa 20
<210> 2039
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2039
ccaaacucac aggcagccca 20
<210> 2040
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2040
ccaaacucca auuccaccau 20
<210> 2041
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2041
ccaaacucuc aggcagccca 20
<210> 2042
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2042
ccaaauauau auaaucauuc 20
<210> 2043
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2043
ccaaauaugu aaacacucaa 20
<210> 2044
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2044
ccaaaucuug uaaaguccaa 20
<210> 2045
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2045
ccaaaugcac ccugaauucu 20
<210> 2046
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2046
ccaaaugccc caacuauaca 20
<210> 2047
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2047
ccaacacccc aguccuaaua 20
<210> 2048
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2048
ccaacagaug accucaauuc 20
<210> 2049
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2049
ccaaccagcg ucagcaacuc 20
<210> 2050
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2050
ccaacccaua aacacccaaa 20
<210> 2051
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2051
ccaaccgcac caucaaugaa 20
<210> 2052
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2052
ccaaccugcu aaccccugaa 20
<210> 2053
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2053
ccaacuauac augaacccga 20
<210> 2054
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2054
ccaagcugca aacucccaaa 20
<210> 2055
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2055
ccaagucucu ggacuuccag 20
<210> 2056
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2056
ccaaucuuua aacccacacu 20
<210> 2057
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2057
ccaaugccau uaucuucucu 20
<210> 2058
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2058
ccaauuccac cauaccugga 20
<210> 2059
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2059
ccaauuccac gauaccugga 20
<210> 2060
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2060
ccaauuccau gauaccugga 20
<210> 2061
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2061
ccacaaacac ccaaaugcac 20
<210> 2062
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2062
ccacaaacac ccaacccaua 20
<210> 2063
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2063
ccacaaacag ggcugguucu 20
<210> 2064
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2064
ccacaaucgc cuaaacccac 20
<210> 2065
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2065
ccacacaucc caccaaaccc 20
<210> 2066
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2066
ccacacaugc cccaaacccu 20
<210> 2067
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2067
ccacacugaa aauugcaagu 20
<210> 2068
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2068
ccacauacac ccuaaaccaa 20
<210> 2069
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2069
ccacauacgc caaaaccucu 20
<210> 2070
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2070
ccacaugggc aggacagcag 20
<210> 2071
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2071
ccaccaaacc cugaaccuuc 20
<210> 2072
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2072
ccaccauacc uggauuccac 20
<210> 2073
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2073
ccaccaugac ucccacucuc 20
<210> 2074
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2074
ccaccccaga accagcccug 20
<210> 2075
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2075
ccaccgucuc aaccacaugg 20
<210> 2076
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2076
ccacgauacc uggauuccac 20
<210> 2077
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2077
ccacggaugu gagacgccag 20
<210> 2078
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2078
ccacucucag ccagcugggc 20
<210> 2079
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2079
ccagaaccag cccuguuugu 20
<210> 2080
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2080
ccagacccac aaucgccuaa 20
<210> 2081
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2081
ccagagaaga uaauggcauu 20
<210> 2082
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2082
ccagagacuu ggaggaguug 20
<210> 2083
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2083
ccagaggcug gggcacacag 20
<210> 2084
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2084
ccagcccugu uuguggguag 20
<210> 2085
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2085
ccagccuaaa ccuccaacac 20
<210> 2086
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2086
ccagccucug guccuggaga 20
<210> 2087
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2087
ccagcgucag caacuccucc 20
<210> 2088
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2088
ccagcuggcu gagaguggga 20
<210> 2089
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2089
ccagcugggc cuggccuuug 20
<210> 2090
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2090
ccaggaccag aggcuggggc 20
<210> 2091
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2091
ccaggcccag cuggcugaga 20
<210> 2092
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2092
ccaggcgcug acuccaguga 20
<210> 2093
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2093
ccaggcuuuc aaaggccagg 20
<210> 2094
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2094
ccagguauca uggaauugga 20
<210> 2095
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2095
ccagguaucg uggaauugga 20
<210> 2096
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2096
ccagguaugg uggaauugga 20
<210> 2097
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2097
ccaggucccu guagaauuca 20
<210> 2098
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2098
ccaguccuaa uaaauacaau 20
<210> 2099
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2099
ccaguccuca cuggagucag 20
<210> 2100
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2100
ccagugacug ccggcgcacu 20
<210> 2101
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2101
ccagugagga cuggcgucuc 20
<210> 2102
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2102
ccauaaacac ccaaacucuc 20
<210> 2103
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2103
ccauaccugg auuccacaaa 20
<210> 2104
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2104
ccaucaauga acaccacaua 20
<210> 2105
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2105
ccaugacucc cacucucagc 20
<210> 2106
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2106
ccaugauacc uggauuccac 20
<210> 2107
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2107
ccaugugguu gagacggugg 20
<210> 2108
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2108
ccauuaucuu cucugggcac 20
<210> 2109
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2109
cccaaaccca cauacgccaa 20
<210> 2110
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2110
cccaaaccca gccuaaaccu 20
<210> 2111
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2111
cccaaacccu aaaccucuac 20
<210> 2112
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2112
cccaaacuca caggcagccc 20
<210> 2113
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2113
cccaaacucc aauuccacca 20
<210> 2114
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2114
cccaaacucu caggcagccc 20
<210> 2115
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2115
cccaaauaua uauaaucauu 20
<210> 2116
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2116
cccaaaucuu guaaagucca 20
<210> 2117
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2117
cccaaaugca cccugaauuc 20
<210> 2118
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2118
cccaaauguc ugcuuccacc 20
<210> 2119
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2119
cccaacccau aaacacccaa 20
<210> 2120
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2120
cccaaccgca ccaucaauga 20
<210> 2121
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2121
cccaaccugc uaaccccuga 20
<210> 2122
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2122
cccaacuaua caugaacccg 20
<210> 2123
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2123
cccaagcugc aaacucccaa 20
<210> 2124
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2124
cccacaaaca gggcugguuc 20
<210> 2125
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2125
cccacaaucg ccuaaaccca 20
<210> 2126
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2126
cccacacaug ccccaaaccc 20
<210> 2127
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2127
cccacacuga aaauugcaag 20
<210> 2128
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2128
cccacauacg ccaaaaccuc 20
<210> 2129
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2129
cccaccaaac ccugaaccuu 20
<210> 2130
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2130
cccacucccg ugccccacuc 20
<210> 2131
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2131
cccacucuca gccagcuggg 20
<210> 2132
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2132
cccagaacca gcccuguuug 20
<210> 2133
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2133
cccagagaag auaauggcau 20
<210> 2134
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2134
cccagccuaa accuccaaca 20
<210> 2135
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2135
cccagccucu gguccuggag 20
<210> 2136
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2136
cccagcuggc ugagaguggg 20
<210> 2137
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2137
cccaggcuuu caaaggccag 20
<210> 2138
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2138
cccaguccua auaaauacaa 20
<210> 2139
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2139
cccauaaaca cccaaacucu 20
<210> 2140
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2140
cccauguggu ugagacggug 20
<210> 2141
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2141
ccccaaaccc agccuaaacc 20
<210> 2142
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2142
ccccaaaccc uaaaccucua 20
<210> 2143
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2143
ccccaaaugu cugcuuccac 20
<210> 2144
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2144
ccccaaccgc accaucaaug 20
<210> 2145
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2145
ccccaacuau acaugaaccc 20
<210> 2146
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2146
ccccaagcug caaacuccca 20
<210> 2147
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2147
ccccagaacc agcccuguuu 20
<210> 2148
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2148
ccccagccuc ugguccugga 20
<210> 2149
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2149
ccccaguccu aauaaauaca 20
<210> 2150
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2150
cccccaaaug ucugcuucca 20
<210> 2151
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2151
cccccaaccg caccaucaau 20
<210> 2152
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2152
cccccucguu gcccaggcuu 20
<210> 2153
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2153
ccccucguug cccaggcuuu 20
<210> 2154
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2154
ccccugaauc cacaaacacc 20
<210> 2155
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2155
cccgaaguag ccaaucuuua 20
<210> 2156
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2156
cccggacacc cucaacucua 20
<210> 2157
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2157
cccuaaacca acagaugacc 20
<210> 2158
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2158
cccuaaaccu cuaccucucu 20
<210> 2159
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2159
cccucaacuc uaccuaccca 20
<210> 2160
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2160
cccucguugc ccaggcuuuc 20
<210> 2161
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2161
cccugaaccu uccaaccagc 20
<210> 2162
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2162
cccugaaucc acaaacaccc 20
<210> 2163
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2163
cccugaauuc uacagggacc 20
<210> 2164
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2164
cccuguagaa uucagggugc 20
<210> 2165
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2165
cccuguuugu ggguagaguc 20
<210> 2166
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2166
ccgaaguagc caaucuuuaa 20
<210> 2167
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2167
ccgcaccauc aaugaacacc 20
<210> 2168
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2168
ccggacaccc ucaacucuac 20
<210> 2169
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2169
ccggcaguca cuggauccuc 20
<210> 2170
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2170
ccggcgcacu ugccaaugcc 20
<210> 2171
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2171
ccgggaguuu gaguguuuac 20
<210> 2172
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2172
ccgucucaac cacaugggca 20
<210> 2173
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2173
ccguggaaug acaagcccac 20
<210> 2174
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2174
ccuaaaccaa cagaugaccu 20
<210> 2175
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2175
ccuaaaccca cacaugcccc 20
<210> 2176
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2176
ccuaaaccuc caacacccca 20
<210> 2177
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2177
ccuaaaccuc uaccucucua 20
<210> 2178
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2178
ccuacccaaa cccacauacg 20
<210> 2179
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2179
ccucaaaucu uagagcaccc 20
<210> 2180
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2180
ccucaacucu accuacccaa 20
<210> 2181
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2181
ccucaauucu agaaacaucc 20
<210> 2182
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2182
ccucacugga gucagcgccu 20
<210> 2183
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2183
ccuccaacac cccaguccua 20
<210> 2184
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2184
ccuccaaguc ucuggacuuc 20
<210> 2185
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2185
ccucguugcc caggcuuuca 20
<210> 2186
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2186
ccucuaaacc ucaaaucuua 20
<210> 2187
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2187
ccucuaccuc ucuaaacacu 20
<210> 2188
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2188
ccucuccagg accagaggcu 20
<210> 2189
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2189
ccucucuaaa cacuccaaau 20
<210> 2190
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2190
ccucuggucc uggagaggau 20
<210> 2191
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2191
ccugaaccuu ccaaccagcg 20
<210> 2192
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2192
ccugaaucca caaacaccca 20
<210> 2193
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2193
ccugaauucu acagggaccu 20
<210> 2194
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2194
ccugagaguu uggguguuua 20
<210> 2195
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2195
ccugccaggc gcugacucca 20
<210> 2196
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2196
ccugcccaug ugguugagac 20
<210> 2197
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2197
ccugcuaacc ccugaaucca 20
<210> 2198
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2198
ccuggacccc caaaugucug 20
<210> 2199
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2199
ccuggagagg auccagugac 20
<210> 2200
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2200
ccuggauucc acaaacaccc 20
<210> 2201
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2201
ccuggcaggc ugugugcccc 20
<210> 2202
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2202
ccuggccuuu gaaagccugg 20
<210> 2203
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2203
ccugggcaac gagggggcca 20
<210> 2204
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2204
ccuguagaau ucagggugca 20
<210> 2205
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2205
ccuguuugug gguagaguca 20
<210> 2206
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2206
ccuuccaacc agcgucagca 20
<210> 2207
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2207
ccuuugaaag ccugggcaac 20
<210> 2208
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2208
cgaaguagcc aaucuuuaaa 20
<210> 2209
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2209
cgagggggcc acacauccca 20
<210> 2210
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2210
cgauaccugg auuccacaaa 20
<210> 2211
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2211
cgauuguggg ucuggaaguc 20
<210> 2212
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2212
cgcaccauca augaacacca 20
<210> 2213
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2213
cgcacuugcc aaugccauua 20
<210> 2214
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2214
cgccaaaacc ucuaaaccuc 20
<210> 2215
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2215
cgccaguccu cacuggaguc 20
<210> 2216
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2216
cgccggcagu cacuggaucc 20
<210> 2217
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2217
cgccuaaacc cacacaugcc 20
<210> 2218
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2218
cgccuggcag gcugugugcc 20
<210> 2219
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2219
cgcugacucc agugaggacu 20
<210> 2220
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2220
cgcugguugg aagguucagg 20
<210> 2221
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2221
cggacacccu caacucuacc 20
<210> 2222
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2222
cggagguuug gacuuuacaa 20
<210> 2223
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2223
cggagugggg cacgggagug 20
<210> 2224
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2224
cggaugugag acgccagucc 20
<210> 2225
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2225
cggcagucac uggauccucu 20
<210> 2226
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2226
cggcgcacuu gccaaugcca 20
<210> 2227
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2227
cgggaguggg cuugucauuc 20
<210> 2228
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2228
cgggaguuug aguguuuaca 20
<210> 2229
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2229
cggguucaug uauaguuggg 20
<210> 2230
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2230
cgguggcagu gcccagagaa 20
<210> 2231
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2231
cguauguggg uuuggguagg 20
<210> 2232
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2232
cgucagcaac uccuccaagu 20
<210> 2233
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2233
cgucucaacc acaugggcag 20
<210> 2234
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2234
cgucucacau ccguggaaug 20
<210> 2235
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2235
cguggaauga caagcccacu 20
<210> 2236
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2236
cguggaauug gaguuuauau 20
<210> 2237
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2237
cguugcccag gcuuucaaag 20
<210> 2238
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2238
cuaaacacuc caaauaugua 20
<210> 2239
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2239
cuaaaccaac agaugaccuc 20
<210> 2240
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2240
cuaaacccac acaugcccca 20
<210> 2241
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2241
cuaaaccuca aaucuuagag 20
<210> 2242
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2242
cuaaaccucc aacaccccag 20
<210> 2243
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2243
cuaaaccucu accucucuaa 20
<210> 2244
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2244
cuaaccccug aauccacaaa 20
<210> 2245
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2245
cuaagauuug agguuuagag 20
<210> 2246
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2246
cuacagggac cuggaccccc 20
<210> 2247
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2247
cuacccaaac ccacauacgc 20
<210> 2248
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2248
cuacccacaa acagggcugg 20
<210> 2249
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2249
cuaccuaccc aaacccacau 20
<210> 2250
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2250
cuaccucucu aaacacucca 20
<210> 2251
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2251
cuacuucggg uucauguaua 20
<210> 2252
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2252
cuagaaacau cccaaacucc 20
<210> 2253
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2253
cuagaauuga ggucaucugu 20
<210> 2254
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2254
cuauacauga acccgaagua 20
<210> 2255
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2255
cucaaacucc cggacacccu 20
<210> 2256
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2256
cucaaaucuu agagcacccc 20
<210> 2257
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2257
cucaaccaca ugggcaggac 20
<210> 2258
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2258
cucaacucua ccuacccaaa 20
<210> 2259
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2259
cucaauucua gaaacauccc 20
<210> 2260
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2260
cucacaggca gcccaaauau 20
<210> 2261
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2261
cucacaggca gcccaaaugu 20
<210> 2262
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2262
cucacauccg uggaaugaca 20
<210> 2263
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2263
cucacuggag ucagcgccug 20
<210> 2264
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2264
cucagccagc ugggccuggc 20
<210> 2265
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2265
cucaggcagc ccaaauguau 20
<210> 2266
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2266
cuccaaauau guaaacacuc 20
<210> 2267
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2267
cuccaacacc ccaguccuaa 20
<210> 2268
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2268
cuccaagucu cuggacuucc 20
<210> 2269
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2269
cuccaauucc accauaccug 20
<210> 2270
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2270
cuccaauucc acgauaccug 20
<210> 2271
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2271
cuccaauucc augauaccug 20
<210> 2272
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2272
cuccaggacc agaggcuggg 20
<210> 2273
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2273
cuccagugag gacuggcguc 20
<210> 2274
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2274
cucccaaauc uuguaaaguc 20
<210> 2275
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2275
cucccacucu cagccagcug 20
<210> 2276
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2276
cucccggaca cccucaacuc 20
<210> 2277
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2277
cuccuccaag ucucuggacu 20
<210> 2278
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2278
cucggagguu uggacuuuac 20
<210> 2279
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2279
cucguugccc aggcuuucaa 20
<210> 2280
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2280
cucuaaacac uccaaauaug 20
<210> 2281
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2281
cucuaaaccu caaaucuuag 20
<210> 2282
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2282
cucuaagauu ugagguuuag 20
<210> 2283
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2283
cucuacccac aaacagggcu 20
<210> 2284
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2284
cucuaccuac ccaaacccac 20
<210> 2285
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2285
cucuaccucu cuaaacacuc 20
<210> 2286
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2286
cucucagcca gcugggccug 20
<210> 2287
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2287
cucucaggca gcccaaaugu 20
<210> 2288
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2288
cucuccagga ccagaggcug 20
<210> 2289
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2289
cucucuaaac acuccaaaua 20
<210> 2290
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2290
cucuggacuu ccagacccac 20
<210> 2291
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2291
cucugggcac ugccaccguc 20
<210> 2292
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2292
cucugguccu ggagaggauc 20
<210> 2293
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2293
cugaaaauug caagucccca 20
<210> 2294
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2294
cugaaccuuc caaccagcgu 20
<210> 2295
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2295
cugaauccac aaacacccaa 20
<210> 2296
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2296
cugaauucua cagggaccug 20
<210> 2297
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2297
cugacgcugg uuggaagguu 20
<210> 2298
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2298
cugacuccag ugaggacugg 20
<210> 2299
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2299
cugagagugg gagucauggu 20
<210> 2300
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2300
cugagaguuu ggguguuuau 20
<210> 2301
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2301
cugcaaacuc ccaaaucuug 20
<210> 2302
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2302
cugccaccgu cucaaccaca 20
<210> 2303
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2303
cugccaggcg cugacuccag 20
<210> 2304
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2304
cugcccaugu gguugagacg 20
<210> 2305
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2305
cugccggcgc acuugccaau 20
<210> 2306
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2306
cugccugaga guuugggugu 20
<210> 2307
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2307
cugcuaaccc cugaauccac 20
<210> 2308
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2308
cugcuguccu gcccaugugg 20
<210> 2309
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2309
cugcuuccac cccagaacca 20
<210> 2310
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2310
cuggaagucc agagacuugg 20
<210> 2311
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2311
cuggaccccc aaaugucugc 20
<210> 2312
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2312
cuggacuucc agacccacaa 20
<210> 2313
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2313
cuggagagga uccagugacu 20
<210> 2314
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2314
cuggagucag cgccuggcag 20
<210> 2315
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2315
cuggauccuc uccaggacca 20
<210> 2316
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2316
cuggauucca caaacaccca 20
<210> 2317
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2317
cuggcaggcu gugugcccca 20
<210> 2318
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2318
cuggccuuug aaagccuggg 20
<210> 2319
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2319
cuggcgucuc acauccgugg 20
<210> 2320
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2320
cuggcugaga gugggaguca 20
<210> 2321
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2321
cugggcaacg agggggccac 20
<210> 2322
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2322
cugggcacug ccaccgucuc 20
<210> 2323
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2323
cugggccugg ccuuugaaag 20
<210> 2324
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2324
cuggggcaca cagccugcca 20
<210> 2325
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2325
cuggggugga agcagacauu 20
<210> 2326
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2326
cugggguguu ggagguuuag 20
<210> 2327
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2327
cuggguuugg ggugcucuaa 20
<210> 2328
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2328
cugguccugg agaggaucca 20
<210> 2329
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2329
cugguucugg gguggaagca 20
<210> 2330
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2330
cugguuggaa gguucagggu 20
<210> 2331
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2331
cuguagaauu cagggugcau 20
<210> 2332
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2332
cuguccugcc caugugguug 20
<210> 2333
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2333
cugucggagu ggggcacggg 20
<210> 2334
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2334
cugugugccc cagccucugg 20
<210> 2335
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2335
cuguugguuu aggguguaug 20
<210> 2336
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2336
cuguuugugg guagagucau 20
<210> 2337
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2337
cuuagagcac cccaaaccca 20
<210> 2338
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2338
cuuccaacca gcgucagcaa 20
<210> 2339
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2339
cuuccacccc agaaccagcc 20
<210> 2340
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2340
cuuccagacc cacaaucgcc 20
<210> 2341
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2341
cuucggguuc auguauaguu 20
<210> 2342
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2342
cuucucuggg cacugccacc 20
<210> 2343
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2343
cuugcaauuu ucaguguggg 20
<210> 2344
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2344
cuugccaaug ccauuaucuu 20
<210> 2345
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2345
cuuggaggag uugcugacgc 20
<210> 2346
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2346
cuuggggacu ugcaauuuuc 20
<210> 2347
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2347
cuuguaaagu ccaaaccucc 20
<210> 2348
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2348
cuugucauuc cacggaugug 20
<210> 2349
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2349
cuuuaaaccc acacugaaaa 20
<210> 2350
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2350
cuuuacaaga uuugggaguu 20
<210> 2351
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2351
cuuucaaagg ccaggcccag 20
<210> 2352
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2352
cuuugaaagc cugggcaacg 20
<210> 2353
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2353
gaaaauugca aguccccaag 20
<210> 2354
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2354
gaaacauccc aaacuccaau 20
<210> 2355
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2355
gaaagccugg gcaacgaggg 20
<210> 2356
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2356
gaacaccaca uacacccuaa 20
<210> 2357
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2357
gaaccagccc uguuuguggg 20
<210> 2358
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2358
gaacccgaag uagccaaucu 20
<210> 2359
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2359
gaaccuucca accagcguca 20
<210> 2360
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2360
gaagauaaug gcauuggcaa 20
<210> 2361
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2361
gaagcagaca uuuggggguc 20
<210> 2362
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2362
gaagguucag gguuuggugg 20
<210> 2363
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2363
gaaguagcca aucuuuaaac 20
<210> 2364
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2364
gaaguccaga gacuuggagg 20
<210> 2365
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2365
gaauccacaa acacccaaau 20
<210> 2366
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2366
gaauccaggu aucauggaau 20
<210> 2367
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2367
gaauccaggu aucguggaau 20
<210> 2368
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2368
gaauccaggu augguggaau 20
<210> 2369
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2369
gaaugacaag cccacucccg 20
<210> 2370
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2370
gaaugauuau auauauuugg 20
<210> 2371
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2371
gaauucaggg ugcauuuggg 20
<210> 2372
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2372
gaauucuaca gggaccugga 20
<210> 2373
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2373
gaauugaggu caucuguugg 20
<210> 2374
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2374
gaauugauug uauuuauuag 20
<210> 2375
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2375
gaauuggagu uugggauguu 20
<210> 2376
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2376
gacaagccca cucccgugcc 20
<210> 2377
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2377
gacacccuca acucuaccua 20
<210> 2378
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2378
gacagcagcc accaugacuc 20
<210> 2379
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2379
gacauuuggg gguccagguc 20
<210> 2380
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2380
gaccagaggc uggggcacac 20
<210> 2381
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2381
gacccacaau cgccuaaacc 20
<210> 2382
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2382
gacccccaaa ugucugcuuc 20
<210> 2383
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2383
gaccucaauu cuagaaacau 20
<210> 2384
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2384
gaccuggacc cccaaauguc 20
<210> 2385
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2385
gacgccaguc cucacuggag 20
<210> 2386
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2386
gacgcugguu ggaagguuca 20
<210> 2387
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2387
gacgguggca gugcccagag 20
<210> 2388
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2388
gacuccagug aggacuggcg 20
<210> 2389
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2389
gacucccacu cucagccagc 20
<210> 2390
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2390
gacucggagg uuuggacuuu 20
<210> 2391
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2391
gacucuaccc acaaacaggg 20
<210> 2392
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2392
gacugccggc gcacuugcca 20
<210> 2393
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2393
gacuggcguc ucacauccgu 20
<210> 2394
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2394
gacuggggug uuggagguuu 20
<210> 2395
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2395
gacuuccaga cccacaaucg 20
<210> 2396
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2396
gacuugcaau uuucagugug 20
<210> 2397
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2397
gacuuggagg aguugcugac 20
<210> 2398
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2398
gacuuuacaa gauuugggag 20
<210> 2399
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2399
gagaagauaa uggcauuggc 20
<210> 2400
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2400
gagacgccag uccucacugg 20
<210> 2401
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2401
gagacggugg cagugcccag 20
<210> 2402
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2402
gagacucgga gguuuggacu 20
<210> 2403
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2403
gagacuugga ggaguugcug 20
<210> 2404
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2404
gagaggaucc agugacugcc 20
<210> 2405
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2405
gagagguaga gguuuagggu 20
<210> 2406
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2406
gagaguggga gucauggugg 20
<210> 2407
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2407
gagaguuugg guguuuaugg 20
<210> 2408
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2408
gagcacccca aacccagccu 20
<210> 2409
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2409
gaggacuggc gucucacauc 20
<210> 2410
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2410
gaggaguugc ugacgcuggu 20
<210> 2411
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2411
gaggauccag ugacugccgg 20
<210> 2412
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2412
gaggcugggg cacacagccu 20
<210> 2413
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2413
gagggggcca cacaucccac 20
<210> 2414
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2414
gagggugucc gggaguuuga 20
<210> 2415
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2415
gagguagagg uuuaggguuu 20
<210> 2416
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2416
gaggucaucu guugguuuag 20
<210> 2417
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2417
gagguuuaga gguuuuggcg 20
<210> 2418
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2418
gagguuuagg cuggguuugg 20
<210> 2419
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2419
gagguuuagg guuuggggca 20
<210> 2420
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2420
gagguuugga cuuuacaaga 20
<210> 2421
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2421
gagguuuugg cguauguggg 20
<210> 2422
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2422
gagucagcgc cuggcaggcu 20
<210> 2423
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2423
gagucauggu ggcugcuguc 20
<210> 2424
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2424
gagugggagu caugguggcu 20
<210> 2425
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2425
gagugggcuu gucauuccac 20
<210> 2426
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2426
gaguggggca cgggaguggg 20
<210> 2427
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2427
gagugguuau gacucuaccc 20
<210> 2428
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2428
gaguguuuac auauuuggag 20
<210> 2429
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2429
gaguguuuag agagguagag 20
<210> 2430
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2430
gaguugaggg uguccgggag 20
<210> 2431
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2431
gaguugcuga cgcugguugg 20
<210> 2432
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2432
gaguuugagu guuuacauau 20
<210> 2433
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2433
gaguuugcag cuuggggacu 20
<210> 2434
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2434
gaguuuggga uguuucuaga 20
<210> 2435
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2435
gauaauggca uuggcaagug 20
<210> 2436
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2436
gauccaguga cugccggcgc 20
<210> 2437
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2437
gauccucucc aggaccagag 20
<210> 2438
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2438
gaugaccuca auucuagaaa 20
<210> 2439
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2439
gaugugagac gccaguccuc 20
<210> 2440
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2440
gauguguggc ccccucguug 20
<210> 2441
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2441
gauguuucua gaauugaggu 20
<210> 2442
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2442
gauuauauau auuugggcug 20
<210> 2443
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2443
gauucagggg uuagcagguu 20
<210> 2444
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2444
gauuccacaa acacccaacc 20
<210> 2445
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2445
gauuggcuac uucggguuca 20
<210> 2446
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2446
gauuguauuu auuaggacug 20
<210> 2447
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2447
gauugugggu cuggaagucc 20
<210> 2448
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2448
gauuugaggu uuagagguuu 20
<210> 2449
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2449
gauuugggag uuugcagcuu 20
<210> 2450
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2450
gcaaacuccc aaaucuugua 20
<210> 2451
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2451
gcaacgaggg ggccacacau 20
<210> 2452
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2452
gcaacuccuc caagucucug 20
<210> 2453
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2453
gcaagucccc aagcugcaaa 20
<210> 2454
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2454
gcaagugcgc cggcagucac 20
<210> 2455
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2455
gcaauuuuca guguggguuu 20
<210> 2456
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2456
gcacacagcc ugccaggcgc 20
<210> 2457
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2457
gcaccaucaa ugaacaccac 20
<210> 2458
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2458
gcaccccaaa cccagccuaa 20
<210> 2459
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2459
gcacccugaa uucuacaggg 20
<210> 2460
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2460
gcacgggagu gggcuuguca 20
<210> 2461
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2461
gcacugccac cgucucaacc 20
<210> 2462
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2462
gcacuugcca augccauuau 20
<210> 2463
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2463
gcagacauuu ggggguccag 20
<210> 2464
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2464
gcagccacca ugacucccac 20
<210> 2465
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2465
gcagcccaaa uauauauaau 20
<210> 2466
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2466
gcagcuuggg gacuugcaau 20
<210> 2467
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2467
gcaggacagc agccaccaug 20
<210> 2468
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2468
gcaggcugug ugccccagcc 20
<210> 2469
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2469
gcagguuggg aaugauuaua 20
<210> 2470
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2470
gcagucacug gauccucucc 20
<210> 2471
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2471
gcagugccca gagaagauaa 20
<210> 2472
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2472
gcaugugugg guuuaggcga 20
<210> 2473
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2473
gcauuggcaa gugcgccggc 20
<210> 2474
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2474
gcauuugggu guuuguggau 20
<210> 2475
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2475
gccaaaaccu cuaaaccuca 20
<210> 2476
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2476
gccaaucuuu aaacccacac 20
<210> 2477
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2477
gccaaugcca uuaucuucuc 20
<210> 2478
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2478
gccacacauc ccaccaaacc 20
<210> 2479
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2479
gccaccauga cucccacucu 20
<210> 2480
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2480
gccaccgucu caaccacaug 20
<210> 2481
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2481
gccagcuggg ccuggccuuu 20
<210> 2482
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2482
gccaggccca gcuggcugag 20
<210> 2483
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2483
gccaggcgcu gacuccagug 20
<210> 2484
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2484
gccaguccuc acuggaguca 20
<210> 2485
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2485
gccauuaucu ucucugggca 20
<210> 2486
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2486
gcccaaauau auauaaucau 20
<210> 2487
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2487
gcccacuccc gugccccacu 20
<210> 2488
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2488
gcccagagaa gauaauggca 20
<210> 2489
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2489
gcccagcugg cugagagugg 20
<210> 2490
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2490
gcccaggcuu ucaaaggcca 20
<210> 2491
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2491
gcccaugugg uugagacggu 20
<210> 2492
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2492
gccccaaacc cuaaaccucu 20
<210> 2493
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2493
gccccaacua uacaugaacc 20
<210> 2494
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2494
gccccagccu cugguccugg 20
<210> 2495
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2495
gcccccucgu ugcccaggcu 20
<210> 2496
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2496
gcccuguuug uggguagagu 20
<210> 2497
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2497
gccggcaguc acuggauccu 20
<210> 2498
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2498
gccggcgcac uugccaaugc 20
<210> 2499
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2499
gccuaaaccc acacaugccc 20
<210> 2500
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2500
gccuaaaccu ccaacacccc 20
<210> 2501
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2501
gccucugguc cuggagagga 20
<210> 2502
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2502
gccugagagu uuggguguuu 20
<210> 2503
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2503
gccugccagg cgcugacucc 20
<210> 2504
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2504
gccuggcagg cugugugccc 20
<210> 2505
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2505
gccuggccuu ugaaagccug 20
<210> 2506
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2506
gccugggcaa cgagggggcc 20
<210> 2507
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2507
gccuuugaaa gccugggcaa 20
<210> 2508
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2508
gcgauugugg gucuggaagu 20
<210> 2509
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2509
gcgcacuugc caaugccauu 20
<210> 2510
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2510
gcgccggcag ucacuggauc 20
<210> 2511
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2511
gcgccuggca ggcugugugc 20
<210> 2512
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2512
gcgcugacuc cagugaggac 20
<210> 2513
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2513
gcguaugugg guuuggguag 20
<210> 2514
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2514
gcgucagcaa cuccuccaag 20
<210> 2515
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2515
gcgucucaca uccguggaau 20
<210> 2516
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2516
gcuaaccccu gaauccacaa 20
<210> 2517
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2517
gcuacuucgg guucauguau 20
<210> 2518
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2518
gcucuaagau uugagguuua 20
<210> 2519
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2519
gcugacgcug guuggaaggu 20
<210> 2520
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2520
gcugacucca gugaggacug 20
<210> 2521
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2521
gcugagagug ggagucaugg 20
<210> 2522
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2522
gcugcaaacu cccaaaucuu 20
<210> 2523
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2523
gcugccugag aguuugggug 20
<210> 2524
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2524
gcugcugucc ugcccaugug 20
<210> 2525
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2525
gcuggcugag agugggaguc 20
<210> 2526
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2526
gcugggccug gccuuugaaa 20
<210> 2527
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2527
gcuggggcac acagccugcc 20
<210> 2528
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2528
gcuggguuug gggugcucua 20
<210> 2529
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2529
gcugguucug ggguggaagc 20
<210> 2530
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2530
gcugguugga agguucaggg 20
<210> 2531
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2531
gcuguccugc ccaugugguu 20
<210> 2532
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2532
gcugugugcc ccagccucug 20
<210> 2533
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2533
gcuuccaccc cagaaccagc 20
<210> 2534
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2534
gcuuggggac uugcaauuuu 20
<210> 2535
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2535
gcuugucauu ccacggaugu 20
<210> 2536
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2536
gcuuucaaag gccaggccca 20
<210> 2537
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2537
ggaagcagac auuugggggu 20
<210> 2538
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2538
ggaagguuca ggguuuggug 20
<210> 2539
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2539
ggaaguccag agacuuggag 20
<210> 2540
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2540
ggaauccagg uaucauggaa 20
<210> 2541
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2541
ggaauccagg uaucguggaa 20
<210> 2542
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2542
ggaauccagg uaugguggaa 20
<210> 2543
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2543
ggaaugacaa gcccacuccc 20
<210> 2544
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2544
ggaaugauua uauauauuug 20
<210> 2545
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2545
ggaauugauu guauuuauua 20
<210> 2546
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2546
ggaauuggag uuugggaugu 20
<210> 2547
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2547
ggacacccuc aacucuaccu 20
<210> 2548
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2548
ggacagcagc caccaugacu 20
<210> 2549
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2549
ggaccagagg cuggggcaca 20
<210> 2550
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2550
ggacccccaa augucugcuu 20
<210> 2551
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2551
ggaccuggac ccccaaaugu 20
<210> 2552
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2552
ggacuggcgu cucacauccg 20
<210> 2553
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2553
ggacuggggu guuggagguu 20
<210> 2554
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2554
ggacuuccag acccacaauc 20
<210> 2555
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2555
ggacuugcaa uuuucagugu 20
<210> 2556
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2556
ggacuuuaca agauuuggga 20
<210> 2557
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2557
ggagacucgg agguuuggac 20
<210> 2558
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2558
ggagaggauc cagugacugc 20
<210> 2559
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2559
ggaggaguug cugacgcugg 20
<210> 2560
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2560
ggagguuuag gcuggguuug 20
<210> 2561
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2561
ggagguuugg acuuuacaag 20
<210> 2562
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2562
ggagucagcg ccuggcaggc 20
<210> 2563
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2563
ggagucaugg uggcugcugu 20
<210> 2564
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2564
ggagugggcu ugucauucca 20
<210> 2565
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2565
ggaguggggc acgggagugg 20
<210> 2566
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2566
ggaguguuua gagagguaga 20
<210> 2567
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2567
ggaguugcug acgcugguug 20
<210> 2568
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2568
ggaguuugag uguuuacaua 20
<210> 2569
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2569
ggaguuugca gcuuggggac 20
<210> 2570
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2570
ggaguuuggg auguuucuag 20
<210> 2571
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2571
ggauccagug acugccggcg 20
<210> 2572
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2572
ggauccucuc caggaccaga 20
<210> 2573
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2573
ggaugugaga cgccaguccu 20
<210> 2574
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2574
ggaugugugg cccccucguu 20
<210> 2575
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2575
ggauguuucu agaauugagg 20
<210> 2576
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2576
ggauucaggg guuagcaggu 20
<210> 2577
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2577
ggauuccaca aacacccaac 20
<210> 2578
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2578
ggcaacgagg gggccacaca 20
<210> 2579
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2579
ggcaagugcg ccggcaguca 20
<210> 2580
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2580
ggcacacagc cugccaggcg 20
<210> 2581
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2581
ggcacgggag ugggcuuguc 20
<210> 2582
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2582
ggcacugcca ccgucucaac 20
<210> 2583
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2583
ggcagcccaa auauauauaa 20
<210> 2584
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2584
ggcaggacag cagccaccau 20
<210> 2585
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2585
ggcaggcugu gugccccagc 20
<210> 2586
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2586
ggcagucacu ggauccucuc 20
<210> 2587
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2587
ggcaugugug gguuuaggcg 20
<210> 2588
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2588
ggcauuggca agugcgccgg 20
<210> 2589
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2589
ggccacacau cccaccaaac 20
<210> 2590
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2590
ggccaggccc agcuggcuga 20
<210> 2591
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2591
ggcccagcug gcugagagug 20
<210> 2592
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2592
ggcccccucg uugcccaggc 20
<210> 2593
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2593
ggccuggccu uugaaagccu 20
<210> 2594
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2594
ggccuuugaa agccugggca 20
<210> 2595
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2595
ggcgauugug ggucuggaag 20
<210> 2596
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2596
ggcgcacuug ccaaugccau 20
<210> 2597
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2597
ggcgcugacu ccagugagga 20
<210> 2598
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2598
ggcguaugug gguuugggua 20
<210> 2599
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2599
ggcgucucac auccguggaa 20
<210> 2600
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2600
ggcuacuucg gguucaugua 20
<210> 2601
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2601
ggcugccuga gaguuugggu 20
<210> 2602
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2602
ggcugcuguc cugcccaugu 20
<210> 2603
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2603
ggcuggggca cacagccugc 20
<210> 2604
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2604
ggcuggguuu ggggugcucu 20
<210> 2605
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2605
ggcugguucu gggguggaag 20
<210> 2606
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2606
ggcugugugc cccagccucu 20
<210> 2607
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2607
ggcuugucau uccacggaug 20
<210> 2608
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2608
ggcuuucaaa ggccaggccc 20
<210> 2609
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2609
gggaaugauu auauauauuu 20
<210> 2610
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2610
gggaccugga cccccaaaug 20
<210> 2611
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2611
gggacuugca auuuucagug 20
<210> 2612
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2612
gggagucaug guggcugcug 20
<210> 2613
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2613
gggagugggc uugucauucc 20
<210> 2614
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2614
gggaguuuga guguuuacau 20
<210> 2615
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2615
gggaguuugc agcuugggga 20
<210> 2616
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2616
gggaugugug gcccccucgu 20
<210> 2617
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2617
gggauguuuc uagaauugag 20
<210> 2618
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2618
gggcaacgag ggggccacac 20
<210> 2619
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2619
gggcacacag ccugccaggc 20
<210> 2620
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2620
gggcacggga gugggcuugu 20
<210> 2621
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2621
gggcacugcc accgucucaa 20
<210> 2622
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2622
gggcaggaca gcagccacca 20
<210> 2623
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2623
gggcaugugu ggguuuaggc 20
<210> 2624
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2624
gggcauuugg aauugauugu 20
<210> 2625
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2625
gggccacaca ucccaccaaa 20
<210> 2626
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2626
gggccuggcc uuugaaagcc 20
<210> 2627
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2627
gggcugccug agaguuuggg 20
<210> 2628
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2628
gggcugguuc ugggguggaa 20
<210> 2629
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2629
gggcuuguca uuccacggau 20
<210> 2630
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2630
ggggacuugc aauuuucagu 20
<210> 2631
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2631
ggggcacaca gccugccagg 20
<210> 2632
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2632
ggggcacggg agugggcuug 20
<210> 2633
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2633
ggggcaugug uggguuuagg 20
<210> 2634
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2634
ggggcauuug gaauugauug 20
<210> 2635
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2635
ggggccacac aucccaccaa 20
<210> 2636
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2636
gggggccaca caucccacca 20
<210> 2637
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2637
ggggguccag gucccuguag 20
<210> 2638
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2638
gggguccagg ucccuguaga 20
<210> 2639
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2639
ggggugcucu aagauuugag 20
<210> 2640
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2640
gggguggaag cagacauuug 20
<210> 2641
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2641
gggguguugg agguuuaggc 20
<210> 2642
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2642
gggguuagca gguugggaau 20
<210> 2643
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2643
ggguagguag aguugagggu 20
<210> 2644
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2644
ggguccaggu cccuguagaa 20
<210> 2645
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2645
gggucuggaa guccagagac 20
<210> 2646
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2646
gggugcauuu ggguguuugu 20
<210> 2647
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2647
gggugcucua agauuugagg 20
<210> 2648
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2648
ggguggaagc agacauuugg 20
<210> 2649
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2649
ggguguaugu gguguucauu 20
<210> 2650
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2650
ggguguccgg gaguuugagu 20
<210> 2651
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2651
ggguguugga gguuuaggcu 20
<210> 2652
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2652
ggguguuuau ggguugggug 20
<210> 2653
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2653
ggguguuugu ggaauccagg 20
<210> 2654
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2654
ggguguuugu ggauucaggg 20
<210> 2655
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2655
ggguuagcag guugggaaug 20
<210> 2656
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2656
ggguucaugu auaguugggg 20
<210> 2657
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2657
ggguugggug uuuguggaau 20
<210> 2658
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2658
ggguuuaaag auuggcuacu 20
<210> 2659
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2659
ggguuuaggc gauugugggu 20
<210> 2660
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2660
ggguuugggg cauguguggg 20
<210> 2661
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2661
ggguuugggg ugcucuaaga 20
<210> 2662
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2662
ggguuugggu agguagaguu 20
<210> 2663
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2663
ggguuuggug ggaugugugg 20
<210> 2664
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2664
gguagagguu uaggguuugg 20
<210> 2665
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2665
gguagaguug aggguguccg 20
<210> 2666
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2666
gguagguaga guugagggug 20
<210> 2667
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2667
gguaucaugg aauuggaguu 20
<210> 2668
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2668
gguaucgugg aauuggaguu 20
<210> 2669
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2669
gguauggugg aauuggaguu 20
<210> 2670
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2670
ggucaucugu ugguuuaggg 20
<210> 2671
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2671
gguccagguc ccuguagaau 20
<210> 2672
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2672
ggucccugua gaauucaggg 20
<210> 2673
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2673
gguccuggag aggauccagu 20
<210> 2674
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2674
ggucuggaag uccagagacu 20
<210> 2675
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2675
ggugcauuug gguguuugug 20
<210> 2676
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2676
ggugcucuaa gauuugaggu 20
<210> 2677
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2677
gguggaagca gacauuuggg 20
<210> 2678
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2678
gguggaauug gaguuuggga 20
<210> 2679
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2679
gguggcagug cccagagaag 20
<210> 2680
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2680
gguggcugcu guccugccca 20
<210> 2681
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2681
ggugggaugu guggcccccu 20
<210> 2682
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2682
gguguaugug guguucauug 20
<210> 2683
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2683
gguguccggg aguuugagug 20
<210> 2684
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2684
gguguucauu gauggugcgg 20
<210> 2685
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2685
gguguuggag guuuaggcug 20
<210> 2686
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2686
gguguuuaug gguugggugu 20
<210> 2687
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2687
gguguuugug gaauccaggu 20
<210> 2688
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2688
gguguuugug gauucagggg 20
<210> 2689
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2689
gguuagcagg uugggaauga 20
<210> 2690
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2690
gguuaugacu cuacccacaa 20
<210> 2691
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2691
gguucagggu uuggugggau 20
<210> 2692
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2692
gguucaugua uaguuggggc 20
<210> 2693
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2693
gguucugggg uggaagcaga 20
<210> 2694
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2694
gguugagacg guggcagugc 20
<210> 2695
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2695
gguuggaagg uucaggguuu 20
<210> 2696
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2696
gguugggaau gauuauauau 20
<210> 2697
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2697
gguuuaaaga uuggcuacuu 20
<210> 2698
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2698
gguuuagagg uuuuggcgua 20
<210> 2699
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2699
gguuuaggcg auuguggguc 20
<210> 2700
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2700
gguuuaggcu ggguuugggg 20
<210> 2701
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2701
gguuuagggu guauguggug 20
<210> 2702
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2702
gguuuagggu uuggggcaug 20
<210> 2703
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2703
gguuuggacu uuacaagauu 20
<210> 2704
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2704
gguuuggggc augugugggu 20
<210> 2705
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2705
gguuuggggu gcucuaagau 20
<210> 2706
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2706
gguuugggua gguagaguug 20
<210> 2707
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2707
gguuuggugg gauguguggc 20
<210> 2708
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2708
gguuuuggcg uauguggguu 20
<210> 2709
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2709
guaaacacuc aaacucccgg 20
<210> 2710
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2710
guaaagucca aaccuccgag 20
<210> 2711
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2711
guagaauuca gggugcauuu 20
<210> 2712
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2712
guagagguuu aggguuuggg 20
<210> 2713
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2713
guagaguuga ggguguccgg 20
<210> 2714
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2714
guagccaauc uuuaaaccca 20
<210> 2715
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2715
guagguagag uugagggugu 20
<210> 2716
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2716
guauaguugg ggcauuugga 20
<210> 2717
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2717
guauauaaac uccaauucca 20
<210> 2718
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2718
guaucaugga auuggaguuu 20
<210> 2719
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2719
guaucgugga auuggaguuu 20
<210> 2720
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2720
guauggugga auuggaguuu 20
<210> 2721
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2721
guaugugggu uuggguaggu 20
<210> 2722
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2722
guauguggug uucauugaug 20
<210> 2723
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2723
guauuuauua ggacuggggu 20
<210> 2724
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2724
gucacuggau ccucuccagg 20
<210> 2725
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2725
gucagcaacu ccuccaaguc 20
<210> 2726
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2726
gucagcgccu ggcaggcugu 20
<210> 2727
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2727
gucaucuguu gguuuagggu 20
<210> 2728
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2728
gucauggugg cugcuguccu 20
<210> 2729
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2729
gucauuccac ggaugugaga 20
<210> 2730
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2730
guccagagac uuggaggagu 20
<210> 2731
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2731
guccaggucc cuguagaauu 20
<210> 2732
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2732
guccccaagc ugcaaacucc 20
<210> 2733
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2733
gucccuguag aauucagggu 20
<210> 2734
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2734
guccgggagu uugaguguuu 20
<210> 2735
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2735
guccucacug gagucagcgc 20
<210> 2736
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2736
guccugccca ugugguugag 20
<210> 2737
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2737
guccuggaga ggauccagug 20
<210> 2738
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2738
gucggagugg ggcacgggag 20
<210> 2739
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2739
gucucaacca caugggcagg 20
<210> 2740
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2740
gucucacauc cguggaauga 20
<210> 2741
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2741
gucucuggac uuccagaccc 20
<210> 2742
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2742
gucugcuucc accccagaac 20
<210> 2743
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2743
gucuggaagu ccagagacuu 20
<210> 2744
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2744
gugacugccg gcgcacuugc 20
<210> 2745
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2745
gugagacgcc aguccucacu 20
<210> 2746
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2746
gugaggacug gcgucucaca 20
<210> 2747
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2747
gugagugguu augacucuac 20
<210> 2748
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2748
gugcauuugg guguuugugg 20
<210> 2749
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2749
gugcccagag aagauaaugg 20
<210> 2750
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2750
gugccccagc cucugguccu 20
<210> 2751
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2751
gugcgccggc agucacugga 20
<210> 2752
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2752
gugcucuaag auuugagguu 20
<210> 2753
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2753
guggaagcag acauuugggg 20
<210> 2754
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2754
guggaaucca gguaucaugg 20
<210> 2755
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2755
guggaaucca gguaucgugg 20
<210> 2756
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2756
guggaaucca gguauggugg 20
<210> 2757
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2757
guggaaugac aagcccacuc 20
<210> 2758
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2758
guggaauugg aguuuauaua 20
<210> 2759
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2759
guggaauugg aguuugggau 20
<210> 2760
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2760
guggauucag ggguuagcag 20
<210> 2761
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2761
guggcagugc ccagagaaga 20
<210> 2762
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2762
guggcccccu cguugcccag 20
<210> 2763
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2763
guggcugcug uccugcccau 20
<210> 2764
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2764
gugggaguca ugguggcugc 20
<210> 2765
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2765
gugggaugug uggcccccuc 20
<210> 2766
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2766
gugggcuugu cauuccacgg 20
<210> 2767
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2767
guggggcacg ggagugggcu 20
<210> 2768
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2768
gugggucugg aaguccagag 20
<210> 2769
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2769
guggguuuaa agauuggcua 20
<210> 2770
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2770
guggguuuag gcgauugugg 20
<210> 2771
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2771
guggguuugg guagguagag 20
<210> 2772
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2772
gugguguuca uugauggugc 20
<210> 2773
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2773
gugguuauga cucuacccac 20
<210> 2774
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2774
gugguugaga cgguggcagu 20
<210> 2775
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2775
guguaugugg uguucauuga 20
<210> 2776
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2776
guguccggga guuugagugu 20
<210> 2777
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2777
gugugcccca gccucugguc 20
<210> 2778
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2778
guguggcccc cucguugccc 20
<210> 2779
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2779
guguggguuu aaagauuggc 20
<210> 2780
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2780
guguggguuu aggcgauugu 20
<210> 2781
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2781
guguuggagg uuuaggcugg 20
<210> 2782
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2782
guguuuacau auuuggagug 20
<210> 2783
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2783
guguuuagag agguagaggu 20
<210> 2784
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2784
guguuuaugg guuggguguu 20
<210> 2785
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2785
guguuugugg aauccaggua 20
<210> 2786
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2786
guguuugugg auucaggggu 20
<210> 2787
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2787
guuagcaggu ugggaaugau 20
<210> 2788
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2788
guuaugacuc uacccacaaa 20
<210> 2789
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2789
guucaggguu uggugggaug 20
<210> 2790
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2790
guucauguau aguuggggca 20
<210> 2791
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2791
guucuggggu ggaagcagac 20
<210> 2792
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2792
guugagacgg uggcagugcc 20
<210> 2793
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2793
guugagggug uccgggaguu 20
<210> 2794
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2794
guugcccagg cuuucaaagg 20
<210> 2795
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2795
guugcugacg cugguuggaa 20
<210> 2796
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2796
guuggaaggu ucaggguuug 20
<210> 2797
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2797
guuggagguu uaggcugggu 20
<210> 2798
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2798
guugggaaug auuauauaua 20
<210> 2799
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2799
guuggggcau uuggaauuga 20
<210> 2800
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2800
guugguuuag gguguaugug 20
<210> 2801
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2801
guuuaaagau uggcuacuuc 20
<210> 2802
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2802
guuuacauau uuggaguguu 20
<210> 2803
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2803
guuuagagag guagagguuu 20
<210> 2804
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2804
guuuagaggu uuuggcguau 20
<210> 2805
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2805
guuuaggcga uugugggucu 20
<210> 2806
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2806
guuuaggcug gguuuggggu 20
<210> 2807
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2807
guuuagggug uauguggugu 20
<210> 2808
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2808
guuuaggguu uggggcaugu 20
<210> 2809
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2809
guuuauauac auuugggcug 20
<210> 2810
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2810
guuuaugggu uggguguuug 20
<210> 2811
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2811
guuucuagaa uugaggucau 20
<210> 2812
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2812
guuugagugu uuacauauuu 20
<210> 2813
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2813
guuugcagcu uggggacuug 20
<210> 2814
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2814
guuuggacuu uacaagauuu 20
<210> 2815
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2815
guuugggaug uuucuagaau 20
<210> 2816
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2816
guuuggggca uguguggguu 20
<210> 2817
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2817
guuuggggug cucuaagauu 20
<210> 2818
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2818
guuuggguag guagaguuga 20
<210> 2819
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2819
guuugggugu uuauggguug 20
<210> 2820
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2820
guuugguggg auguguggcc 20
<210> 2821
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2821
guuuguggaa uccagguauc 20
<210> 2822
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2822
guuuguggaa uccagguaug 20
<210> 2823
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2823
guuuguggau ucagggguua 20
<210> 2824
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2824
guuugugggu agagucauaa 20
<210> 2825
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2825
guuuuggcgu auguggguuu 20
<210> 2826
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2826
uaaacaccca aacucucagg 20
<210> 2827
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2827
uaaacacuca aacucccgga 20
<210> 2828
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2828
uaaacacucc aaauauguaa 20
<210> 2829
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2829
uaaaccaaca gaugaccuca 20
<210> 2830
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2830
uaaacccaca caugccccaa 20
<210> 2831
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2831
uaaacccaca cugaaaauug 20
<210> 2832
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2832
uaaaccucaa aucuuagagc 20
<210> 2833
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2833
uaaaccucca acaccccagu 20
<210> 2834
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2834
uaaaccucua ccucucuaaa 20
<210> 2835
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2835
uaaacuccaa uuccacgaua 20
<210> 2836
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2836
uaaacuccaa uuccaugaua 20
<210> 2837
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2837
uaaagauugg cuacuucggg 20
<210> 2838
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2838
uaaaguccaa accuccgagu 20
<210> 2839
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2839
uaaauacaau caauuccaaa 20
<210> 2840
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2840
uaaccccuga auccacaaac 20
<210> 2841
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2841
uaagauuuga gguuuagagg 20
<210> 2842
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2842
uaaucauucc caaccugcua 20
<210> 2843
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2843
uaauggcauu ggcaagugcg 20
<210> 2844
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2844
uacaagauuu gggaguuugc 20
<210> 2845
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2845
uacaaucaau uccaaaugcc 20
<210> 2846
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2846
uacacccuaa accaacagau 20
<210> 2847
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2847
uacagggacc uggaccccca 20
<210> 2848
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2848
uacauauuug gaguguuuag 20
<210> 2849
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2849
uacaugaacc cgaaguagcc 20
<210> 2850
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2850
uacauuuggg cugccugaga 20
<210> 2851
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2851
uacauuuggg cugccuguga 20
<210> 2852
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2852
uacccaaacc cacauacgcc 20
<210> 2853
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2853
uacccacaaa cagggcuggu 20
<210> 2854
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2854
uaccuaccca aacccacaua 20
<210> 2855
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2855
uaccucucua aacacuccaa 20
<210> 2856
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2856
uacgccaaaa ccucuaaacc 20
<210> 2857
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2857
uacuucgggu ucauguauag 20
<210> 2858
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2858
uagaaacauc ccaaacucca 20
<210> 2859
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2859
uagaauucag ggugcauuug 20
<210> 2860
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2860
uagaauugag gucaucuguu 20
<210> 2861
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2861
uagagaggua gagguuuagg 20
<210> 2862
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2862
uagagcaccc caaacccagc 20
<210> 2863
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2863
uagagguuua ggguuugggg 20
<210> 2864
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2864
uagagguuuu ggcguaugug 20
<210> 2865
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2865
uagaguugag gguguccggg 20
<210> 2866
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2866
uagcagguug ggaaugauua 20
<210> 2867
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2867
uagccaaucu uuaaacccac 20
<210> 2868
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2868
uaggacuggg guguuggagg 20
<210> 2869
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2869
uaggcgauug ugggucugga 20
<210> 2870
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2870
uaggcugggu uuggggugcu 20
<210> 2871
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2871
uaggguguau gugguguuca 20
<210> 2872
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2872
uaggguuugg ggcaugugug 20
<210> 2873
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2873
uagguagagu ugaggguguc 20
<210> 2874
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2874
uaguuggggc auuuggaauu 20
<210> 2875
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2875
uauaaacucc aauuccacga 20
<210> 2876
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2876
uauaaacucc aauuccauga 20
<210> 2877
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2877
uauaaucauu cccaaccugc 20
<210> 2878
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2878
uauacaugaa cccgaaguag 20
<210> 2879
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2879
uauacauuug ggcugccuga 20
<210> 2880
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2880
uauacauuug ggcugccugu 20
<210> 2881
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2881
uauaguuggg gcauuuggaa 20
<210> 2882
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2882
uauauaaacu ccaauuccac 20
<210> 2883
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2883
uauauaaacu ccaauuccau 20
<210> 2884
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2884
uauauaauca uucccaaccu 20
<210> 2885
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2885
uauauacauu ugggcugccu 20
<210> 2886
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2886
uauauauaau cauucccaac 20
<210> 2887
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2887
uauauauauu ugggcugccu 20
<210> 2888
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2888
uauauauuug ggcugccugu 20
<210> 2889
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2889
uauauuuggg cugccuguga 20
<210> 2890
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2890
uaucguggaa uuggaguuua 20
<210> 2891
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2891
uaucuucucu gggcacugcc 20
<210> 2892
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2892
uaugacucua cccacaaaca 20
<210> 2893
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2893
uauggguugg guguuugugg 20
<210> 2894
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2894
uaugguggaa uuggaguuug 20
<210> 2895
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2895
uauguaaaca cucaaacucc 20
<210> 2896
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2896
uauguggguu uggguaggua 20
<210> 2897
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2897
uauguggugu ucauugaugg 20
<210> 2898
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2898
uauuaggacu gggguguugg 20
<210> 2899
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2899
uauuuauuag gacuggggug 20
<210> 2900
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2900
uauuuggagu guuuagagag 20
<210> 2901
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2901
uauuugggcu gccugugagu 20
<210> 2902
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2902
ucaaacuccc ggacacccuc 20
<210> 2903
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2903
ucaaaggcca ggcccagcug 20
<210> 2904
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2904
ucaaaucuua gagcacccca 20
<210> 2905
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2905
ucaaccacau gggcaggaca 20
<210> 2906
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2906
ucaacucuac cuacccaaac 20
<210> 2907
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2907
ucaaugaaca ccacauacac 20
<210> 2908
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2908
ucaauuccaa augccccaac 20
<210> 2909
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2909
ucaauucuag aaacauccca 20
<210> 2910
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2910
ucacaggcag cccaaauaua 20
<210> 2911
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2911
ucacaggcag cccaaaugua 20
<210> 2912
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2912
ucacauccgu ggaaugacaa 20
<210> 2913
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2913
ucacuggagu cagcgccugg 20
<210> 2914
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2914
ucacuggauc cucuccagga 20
<210> 2915
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2915
ucagcaacuc cuccaagucu 20
<210> 2916
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2916
ucagccagcu gggccuggcc 20
<210> 2917
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2917
ucagcgccug gcaggcugug 20
<210> 2918
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2918
ucaggcagcc caaauguaua 20
<210> 2919
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2919
ucagggguua gcagguuggg 20
<210> 2920
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2920
ucagggugca uuuggguguu 20
<210> 2921
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2921
ucaggguuug gugggaugug 20
<210> 2922
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2922
ucaguguggg uuuaaagauu 20
<210> 2923
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2923
ucaucuguug guuuagggug 20
<210> 2924
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2924
ucaugguggc ugcuguccug 20
<210> 2925
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2925
ucauguauag uuggggcauu 20
<210> 2926
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2926
ucauuccacg gaugugagac 20
<210> 2927
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2927
ucauucccaa ccugcuaacc 20
<210> 2928
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2928
uccaaauaug uaaacacuca 20
<210> 2929
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2929
uccaaaugcc ccaacuauac 20
<210> 2930
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2930
uccaacaccc caguccuaau 20
<210> 2931
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2931
uccaaccagc gucagcaacu 20
<210> 2932
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2932
uccaagucuc uggacuucca 20
<210> 2933
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2933
uccaauucca ccauaccugg 20
<210> 2934
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2934
uccaauucca cgauaccugg 20
<210> 2935
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2935
uccaauucca ugauaccugg 20
<210> 2936
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2936
uccacaaaca cccaaaugca 20
<210> 2937
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2937
uccacaaaca cccaacccau 20
<210> 2938
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2938
uccaccauac cuggauucca 20
<210> 2939
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2939
uccaccccag aaccagcccu 20
<210> 2940
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2940
uccacgauac cuggauucca 20
<210> 2941
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2941
uccacggaug ugagacgcca 20
<210> 2942
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2942
uccagaccca caaucgccua 20
<210> 2943
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2943
uccagagacu uggaggaguu 20
<210> 2944
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2944
uccaggacca gaggcugggg 20
<210> 2945
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2945
uccagguauc auggaauugg 20
<210> 2946
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2946
uccagguauc guggaauugg 20
<210> 2947
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2947
uccagguaug guggaauugg 20
<210> 2948
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2948
uccagguccc uguagaauuc 20
<210> 2949
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2949
uccagugacu gccggcgcac 20
<210> 2950
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2950
uccagugagg acuggcgucu 20
<210> 2951
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2951
uccaugauac cuggauucca 20
<210> 2952
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2952
ucccaaacuc caauuccacc 20
<210> 2953
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2953
ucccaaaucu uguaaagucc 20
<210> 2954
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2954
ucccaaccug cuaaccccug 20
<210> 2955
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2955
ucccaccaaa cccugaaccu 20
<210> 2956
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2956
ucccacucuc agccagcugg 20
<210> 2957
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2957
uccccaagcu gcaaacuccc 20
<210> 2958
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2958
ucccggacac ccucaacucu 20
<210> 2959
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2959
ucccuguaga auucagggug 20
<210> 2960
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2960
uccgggaguu ugaguguuua 20
<210> 2961
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2961
uccguggaau gacaagccca 20
<210> 2962
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2962
uccucacugg agucagcgcc 20
<210> 2963
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2963
uccuccaagu cucuggacuu 20
<210> 2964
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2964
uccucuccag gaccagaggc 20
<210> 2965
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2965
uccugcccau gugguugaga 20
<210> 2966
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2966
uccuggagag gauccaguga 20
<210> 2967
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2967
ucgccuaaac ccacacaugc 20
<210> 2968
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2968
ucggagguuu ggacuuuaca 20
<210> 2969
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2969
ucggaguggg gcacgggagu 20
<210> 2970
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2970
ucggguucau guauaguugg 20
<210> 2971
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2971
ucguggaauu ggaguuuaua 20
<210> 2972
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2972
ucguugccca ggcuuucaaa 20
<210> 2973
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2973
ucuaaacacu ccaaauaugu 20
<210> 2974
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2974
ucuaaaccuc aaaucuuaga 20
<210> 2975
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2975
ucuaagauuu gagguuuaga 20
<210> 2976
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2976
ucuacaggga ccuggacccc 20
<210> 2977
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2977
ucuacccaca aacagggcug 20
<210> 2978
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2978
ucuaccuacc caaacccaca 20
<210> 2979
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2979
ucuaccucuc uaaacacucc 20
<210> 2980
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2980
ucuagaaaca ucccaaacuc 20
<210> 2981
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2981
ucuagaauug aggucaucug 20
<210> 2982
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2982
ucucaaccac augggcagga 20
<210> 2983
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2983
ucucacaucc guggaaugac 20
<210> 2984
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2984
ucucagccag cugggccugg 20
<210> 2985
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2985
ucucaggcag cccaaaugua 20
<210> 2986
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2986
ucuccaggac cagaggcugg 20
<210> 2987
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2987
ucucuaaaca cuccaaauau 20
<210> 2988
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2988
ucucuggacu uccagaccca 20
<210> 2989
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2989
ucucugggca cugccaccgu 20
<210> 2990
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2990
ucugcuucca ccccagaacc 20
<210> 2991
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2991
ucuggaaguc cagagacuug 20
<210> 2992
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2992
ucuggacuuc cagacccaca 20
<210> 2993
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2993
ucugggcacu gccaccgucu 20
<210> 2994
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2994
ucuggggugg aagcagacau 20
<210> 2995
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2995
ucugguccug gagaggaucc 20
<210> 2996
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2996
ucuguugguu uaggguguau 20
<210> 2997
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2997
ucuuagagca ccccaaaccc 20
<210> 2998
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2998
ucuucucugg gcacugccac 20
<210> 2999
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 2999
ucuuguaaag uccaaaccuc 20
<210> 3000
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3000
ucuuuaaacc cacacugaaa 20
<210> 3001
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3001
ugaaaauugc aaguccccaa 20
<210> 3002
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3002
ugaaagccug ggcaacgagg 20
<210> 3003
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3003
ugaacaccac auacacccua 20
<210> 3004
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3004
ugaacccgaa guagccaauc 20
<210> 3005
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3005
ugaaccuucc aaccagcguc 20
<210> 3006
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3006
ugaauccaca aacacccaaa 20
<210> 3007
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3007
ugaauucuac agggaccugg 20
<210> 3008
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3008
ugacaagccc acucccgugc 20
<210> 3009
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3009
ugaccucaau ucuagaaaca 20
<210> 3010
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3010
ugacgcuggu uggaagguuc 20
<210> 3011
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3011
ugacuccagu gaggacuggc 20
<210> 3012
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3012
ugacucccac ucucagccag 20
<210> 3013
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3013
ugacucuacc cacaaacagg 20
<210> 3014
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3014
ugacugccgg cgcacuugcc 20
<210> 3015
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3015
ugagacgcca guccucacug 20
<210> 3016
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3016
ugagacggug gcagugccca 20
<210> 3017
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3017
ugagaguggg agucauggug 20
<210> 3018
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3018
ugagaguuug gguguuuaug 20
<210> 3019
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3019
ugaggacugg cgucucacau 20
<210> 3020
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3020
ugaggguguc cgggaguuug 20
<210> 3021
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3021
ugaggucauc uguugguuua 20
<210> 3022
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3022
ugagguuuag agguuuuggc 20
<210> 3023
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3023
ugagugguua ugacucuacc 20
<210> 3024
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3024
ugaguguuua cauauuugga 20
<210> 3025
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3025
ugauaccugg auuccacaaa 20
<210> 3026
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3026
ugauuauaua uauuugggcu 20
<210> 3027
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3027
ugauuguauu uauuaggacu 20
<210> 3028
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3028
ugcaaacucc caaaucuugu 20
<210> 3029
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3029
ugcaaguccc caagcugcaa 20
<210> 3030
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3030
ugcaauuuuc aguguggguu 20
<210> 3031
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3031
ugcacccuga auucuacagg 20
<210> 3032
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3032
ugcagcuugg ggacuugcaa 20
<210> 3033
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3033
ugcauuuggg uguuugugga 20
<210> 3034
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3034
ugccaaugcc auuaucuucu 20
<210> 3035
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3035
ugccaccguc ucaaccacau 20
<210> 3036
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3036
ugccaggcgc ugacuccagu 20
<210> 3037
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3037
ugccauuauc uucucugggc 20
<210> 3038
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3038
ugcccagaga agauaauggc 20
<210> 3039
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3039
ugcccaggcu uucaaaggcc 20
<210> 3040
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3040
ugcccaugug guugagacgg 20
<210> 3041
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3041
ugccccaaac ccuaaaccuc 20
<210> 3042
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3042
ugccccaacu auacaugaac 20
<210> 3043
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3043
ugccccagcc ucugguccug 20
<210> 3044
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3044
ugccggcgca cuugccaaug 20
<210> 3045
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3045
ugccugagag uuuggguguu 20
<210> 3046
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3046
ugcgccggca gucacuggau 20
<210> 3047
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3047
ugcuaacccc ugaauccaca 20
<210> 3048
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3048
ugcucuaaga uuugagguuu 20
<210> 3049
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3049
ugcugacgcu gguuggaagg 20
<210> 3050
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3050
ugcuguccug cccauguggu 20
<210> 3051
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3051
ugcuuccacc ccagaaccag 20
<210> 3052
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3052
uggaagcaga cauuuggggg 20
<210> 3053
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3053
uggaagguuc aggguuuggu 20
<210> 3054
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3054
uggaagucca gagacuugga 20
<210> 3055
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3055
uggaauccag guaucaugga 20
<210> 3056
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3056
uggaauccag guaucgugga 20
<210> 3057
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3057
uggaauccag guauggugga 20
<210> 3058
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3058
uggaaugaca agcccacucc 20
<210> 3059
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3059
uggaauugga guuugggaug 20
<210> 3060
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3060
uggaccccca aaugucugcu 20
<210> 3061
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3061
uggacuucca gacccacaau 20
<210> 3062
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3062
uggacuuuac aagauuuggg 20
<210> 3063
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3063
uggagacucg gagguuugga 20
<210> 3064
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3064
uggagaggau ccagugacug 20
<210> 3065
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3065
uggaggaguu gcugacgcug 20
<210> 3066
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3066
uggagguuua ggcuggguuu 20
<210> 3067
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3067
uggagucagc gccuggcagg 20
<210> 3068
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3068
uggaguguuu agagagguag 20
<210> 3069
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3069
uggaguuugg gauguuucua 20
<210> 3070
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3070
uggauccucu ccaggaccag 20
<210> 3071
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3071
uggauucagg gguuagcagg 20
<210> 3072
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3072
uggauuccac aaacacccaa 20
<210> 3073
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3073
uggcaagugc gccggcaguc 20
<210> 3074
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3074
uggcaggcug ugugccccag 20
<210> 3075
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3075
uggcagugcc cagagaagau 20
<210> 3076
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3076
uggcauuggc aagugcgccg 20
<210> 3077
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3077
uggcccccuc guugcccagg 20
<210> 3078
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3078
uggccuuuga aagccugggc 20
<210> 3079
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3079
uggcguaugu ggguuugggu 20
<210> 3080
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3080
uggcgucuca cauccgugga 20
<210> 3081
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3081
uggcuacuuc ggguucaugu 20
<210> 3082
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3082
uggcugagag ugggagucau 20
<210> 3083
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3083
uggcugcugu ccugcccaug 20
<210> 3084
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3084
ugggaaugau uauauauauu 20
<210> 3085
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3085
ugggagucau gguggcugcu 20
<210> 3086
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3086
ugggaguuug cagcuugggg 20
<210> 3087
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3087
ugggaugugu ggcccccucg 20
<210> 3088
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3088
ugggauguuu cuagaauuga 20
<210> 3089
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3089
ugggcaacga gggggccaca 20
<210> 3090
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3090
ugggcacugc caccgucuca 20
<210> 3091
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3091
ugggcaggac agcagccacc 20
<210> 3092
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3092
ugggccuggc cuuugaaagc 20
<210> 3093
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3093
ugggcugccu gagaguuugg 20
<210> 3094
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3094
ugggcuuguc auuccacgga 20
<210> 3095
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3095
uggggacuug caauuuucag 20
<210> 3096
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3096
uggggcacac agccugccag 20
<210> 3097
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3097
uggggcacgg gagugggcuu 20
<210> 3098
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3098
uggggcaugu guggguuuag 20
<210> 3099
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3099
uggggcauuu ggaauugauu 20
<210> 3100
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3100
ugggggucca ggucccugua 20
<210> 3101
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3101
uggggugcuc uaagauuuga 20
<210> 3102
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3102
ugggguggaa gcagacauuu 20
<210> 3103
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3103
ugggguguug gagguuuagg 20
<210> 3104
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3104
uggguaggua gaguugaggg 20
<210> 3105
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3105
ugggucugga aguccagaga 20
<210> 3106
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3106
uggguguuua uggguugggu 20
<210> 3107
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3107
uggguguuug uggaauccag 20
<210> 3108
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3108
uggguguuug uggauucagg 20
<210> 3109
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3109
uggguugggu guuuguggaa 20
<210> 3110
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3110
uggguuuaaa gauuggcuac 20
<210> 3111
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3111
uggguuuagg cgauuguggg 20
<210> 3112
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3112
uggguuuggg gugcucuaag 20
<210> 3113
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3113
uggguuuggg uagguagagu 20
<210> 3114
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3114
ugguccugga gaggauccag 20
<210> 3115
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3115
ugguggaauu ggaguuuggg 20
<210> 3116
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3116
ugguggcugc uguccugccc 20
<210> 3117
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3117
uggugggaug uguggccccc 20
<210> 3118
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3118
ugguguucau ugauggugcg 20
<210> 3119
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3119
ugguuaugac ucuacccaca 20
<210> 3120
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3120
ugguucuggg guggaagcag 20
<210> 3121
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3121
ugguugagac gguggcagug 20
<210> 3122
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3122
ugguuggaag guucaggguu 20
<210> 3123
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3123
ugguuuaggg uguauguggu 20
<210> 3124
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3124
uguaaacacu caaacucccg 20
<210> 3125
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3125
uguaaagucc aaaccuccga 20
<210> 3126
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3126
uguagaauuc agggugcauu 20
<210> 3127
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3127
uguauaguug gggcauuugg 20
<210> 3128
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3128
uguauauaaa cuccaauucc 20
<210> 3129
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3129
uguauguggu guucauugau 20
<210> 3130
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3130
uguauuuauu aggacugggg 20
<210> 3131
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3131
ugucauucca cggaugugag 20
<210> 3132
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3132
uguccgggag uuugaguguu 20
<210> 3133
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3133
uguccugccc augugguuga 20
<210> 3134
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3134
ugucggagug gggcacggga 20
<210> 3135
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3135
ugucugcuuc caccccagaa 20
<210> 3136
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3136
ugugagacgc caguccucac 20
<210> 3137
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3137
ugugccccag ccucuggucc 20
<210> 3138
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3138
uguggaaucc agguaucaug 20
<210> 3139
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3139
uguggaaucc agguaucgug 20
<210> 3140
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3140
uguggaaucc agguauggug 20
<210> 3141
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3141
uguggauuca gggguuagca 20
<210> 3142
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3142
uguggccccc ucguugccca 20
<210> 3143
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3143
ugugggucug gaaguccaga 20
<210> 3144
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3144
uguggguuua aagauuggcu 20
<210> 3145
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3145
uguggguuua ggcgauugug 20
<210> 3146
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3146
uguggguuug gguagguaga 20
<210> 3147
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3147
ugugguguuc auugauggug 20
<210> 3148
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3148
ugugguugag acgguggcag 20
<210> 3149
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3149
ugugugcccc agccucuggu 20
<210> 3150
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3150
uguguggccc ccucguugcc 20
<210> 3151
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3151
uguguggguu uaggcgauug 20
<210> 3152
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3152
uguuggaggu uuaggcuggg 20
<210> 3153
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3153
uguugguuua ggguguaugu 20
<210> 3154
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3154
uguuuacaua uuuggagugu 20
<210> 3155
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3155
uguuuagaga gguagagguu 20
<210> 3156
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3156
uguuuauggg uuggguguuu 20
<210> 3157
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3157
uguuucuaga auugagguca 20
<210> 3158
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3158
uguuugugga auccagguau 20
<210> 3159
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3159
uguuugugga uucagggguu 20
<210> 3160
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3160
uguuuguggg uagagucaua 20
<210> 3161
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3161
uuaaacccac acugaaaauu 20
<210> 3162
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3162
uuaaagauug gcuacuucgg 20
<210> 3163
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3163
uuacaagauu ugggaguuug 20
<210> 3164
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3164
uuacauauuu ggaguguuua 20
<210> 3165
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3165
uuagagaggu agagguuuag 20
<210> 3166
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3166
uuagagcacc ccaaacccag 20
<210> 3167
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3167
uuagagguuu uggcguaugu 20
<210> 3168
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3168
uuagcagguu gggaaugauu 20
<210> 3169
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3169
uuaggacugg gguguuggag 20
<210> 3170
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3170
uuaggcgauu gugggucugg 20
<210> 3171
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3171
uuaggcuggg uuuggggugc 20
<210> 3172
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3172
uuagggugua ugugguguuc 20
<210> 3173
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3173
uuaggguuug gggcaugugu 20
<210> 3174
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3174
uuauauacau uugggcugcc 20
<210> 3175
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3175
uuauauauau uugggcugcc 20
<210> 3176
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3176
uuaucuucuc ugggcacugc 20
<210> 3177
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3177
uuaugacucu acccacaaac 20
<210> 3178
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3178
uuauggguug gguguuugug 20
<210> 3179
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3179
uuauuaggac ugggguguug 20
<210> 3180
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3180
uucaaaggcc aggcccagcu 20
<210> 3181
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3181
uucagggguu agcagguugg 20
<210> 3182
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3182
uucagggugc auuugggugu 20
<210> 3183
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3183
uucaggguuu ggugggaugu 20
<210> 3184
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3184
uucagugugg guuuaaagau 20
<210> 3185
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3185
uucauguaua guuggggcau 20
<210> 3186
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3186
uuccaaaugc cccaacuaua 20
<210> 3187
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3187
uuccaaccag cgucagcaac 20
<210> 3188
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3188
uuccacaaac acccaaccca 20
<210> 3189
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3189
uuccaccaua ccuggauucc 20
<210> 3190
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3190
uuccacccca gaaccagccc 20
<210> 3191
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3191
uuccacgaua ccuggauucc 20
<210> 3192
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3192
uuccacggau gugagacgcc 20
<210> 3193
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3193
uuccagaccc acaaucgccu 20
<210> 3194
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3194
uuccaugaua ccuggauucc 20
<210> 3195
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3195
uucccaaccu gcuaaccccu 20
<210> 3196
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3196
uucggguuca uguauaguug 20
<210> 3197
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3197
uucuacaggg accuggaccc 20
<210> 3198
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3198
uucuagaaac aucccaaacu 20
<210> 3199
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3199
uucuagaauu gaggucaucu 20
<210> 3200
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3200
uucucugggc acugccaccg 20
<210> 3201
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3201
uucuggggug gaagcagaca 20
<210> 3202
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3202
uugaaagccu gggcaacgag 20
<210> 3203
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3203
uugagacggu ggcagugccc 20
<210> 3204
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3204
uugagggugu ccgggaguuu 20
<210> 3205
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3205
uugaggucau cuguugguuu 20
<210> 3206
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3206
uugagguuua gagguuuugg 20
<210> 3207
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3207
uugaguguuu acauauuugg 20
<210> 3208
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3208
uugauuguau uuauuaggac 20
<210> 3209
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3209
uugcaagucc ccaagcugca 20
<210> 3210
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3210
uugcaauuuu cagugugggu 20
<210> 3211
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3211
uugcagcuug gggacuugca 20
<210> 3212
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3212
uugccaaugc cauuaucuuc 20
<210> 3213
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3213
uugcccaggc uuucaaaggc 20
<210> 3214
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3214
uugcugacgc ugguuggaag 20
<210> 3215
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3215
uuggaagguu caggguuugg 20
<210> 3216
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3216
uuggacuuua caagauuugg 20
<210> 3217
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3217
uuggagacuc ggagguuugg 20
<210> 3218
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3218
uuggaggagu ugcugacgcu 20
<210> 3219
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3219
uuggagguuu aggcuggguu 20
<210> 3220
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3220
uuggaguguu uagagaggua 20
<210> 3221
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3221
uuggaguuug ggauguuucu 20
<210> 3222
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3222
uuggcaagug cgccggcagu 20
<210> 3223
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3223
uuggcguaug uggguuuggg 20
<210> 3224
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3224
uuggcuacuu cggguucaug 20
<210> 3225
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3225
uugggaauga uuauauauau 20
<210> 3226
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3226
uugggaguuu gcagcuuggg 20
<210> 3227
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3227
uugggauguu ucuagaauug 20
<210> 3228
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3228
uugggcugcc ugagaguuug 20
<210> 3229
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3229
uuggggacuu gcaauuuuca 20
<210> 3230
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3230
uuggggcaug uguggguuua 20
<210> 3231
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3231
uuggggcauu uggaauugau 20
<210> 3232
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3232
uugggggucc aggucccugu 20
<210> 3233
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3233
uuggggugcu cuaagauuug 20
<210> 3234
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3234
uuggguaggu agaguugagg 20
<210> 3235
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3235
uuggguguuu auggguuggg 20
<210> 3236
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3236
uuggguguuu guggaaucca 20
<210> 3237
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3237
uuggguguuu guggauucag 20
<210> 3238
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3238
uuggugggau guguggcccc 20
<210> 3239
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3239
uugguuuagg guguaugugg 20
<210> 3240
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3240
uuguaaaguc caaaccuccg 20
<210> 3241
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3241
uuguauuuau uaggacuggg 20
<210> 3242
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3242
uugucauucc acggauguga 20
<210> 3243
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3243
uuguggaauc cagguaucau 20
<210> 3244
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3244
uuguggaauc cagguaucgu 20
<210> 3245
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3245
uuguggaauc cagguauggu 20
<210> 3246
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3246
uuguggauuc agggguuagc 20
<210> 3247
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3247
uuguggguag agucauaacc 20
<210> 3248
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3248
uugugggucu ggaaguccag 20
<210> 3249
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3249
uuuaaaccca cacugaaaau 20
<210> 3250
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3250
uuuaaagauu ggcuacuucg 20
<210> 3251
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3251
uuuacaagau uugggaguuu 20
<210> 3252
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3252
uuuacauauu uggaguguuu 20
<210> 3253
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3253
uuuagagagg uagagguuua 20
<210> 3254
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3254
uuuagagguu uuggcguaug 20
<210> 3255
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3255
uuuaggcgau ugugggucug 20
<210> 3256
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3256
uuuaggcugg guuuggggug 20
<210> 3257
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3257
uuuagggugu augugguguu 20
<210> 3258
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3258
uuuaggguuu ggggcaugug 20
<210> 3259
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3259
uuuauauaca uuugggcugc 20
<210> 3260
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3260
uuuauggguu ggguguuugu 20
<210> 3261
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3261
uuuauuagga cugggguguu 20
<210> 3262
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3262
uuucaaaggc caggcccagc 20
<210> 3263
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3263
uuucagugug gguuuaaaga 20
<210> 3264
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3264
uuucuagaau ugaggucauc 20
<210> 3265
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3265
uuugaaagcc ugggcaacga 20
<210> 3266
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3266
uuugagguuu agagguuuug 20
<210> 3267
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3267
uuugaguguu uacauauuug 20
<210> 3268
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3268
uuugcagcuu ggggacuugc 20
<210> 3269
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3269
uuuggacuuu acaagauuug 20
<210> 3270
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3270
uuuggagacu cggagguuug 20
<210> 3271
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3271
uuuggagugu uuagagaggu 20
<210> 3272
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3272
uuuggcguau guggguuugg 20
<210> 3273
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3273
uuugggaguu ugcagcuugg 20
<210> 3274
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3274
uuugggaugu uucuagaauu 20
<210> 3275
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3275
uuugggcugc cugagaguuu 20
<210> 3276
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3276
uuuggggcau guguggguuu 20
<210> 3277
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3277
uuuggggguc caggucccug 20
<210> 3278
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3278
uuuggggugc ucuaagauuu 20
<210> 3279
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3279
uuuggguagg uagaguugag 20
<210> 3280
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3280
uuuggguguu uauggguugg 20
<210> 3281
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3281
uuuggguguu uguggauuca 20
<210> 3282
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3282
uuugguggga uguguggccc 20
<210> 3283
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3283
uuuguggaau ccagguauca 20
<210> 3284
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3284
uuuguggaau ccagguaucg 20
<210> 3285
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3285
uuuguggaau ccagguaugg 20
<210> 3286
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3286
uuuguggauu cagggguuag 20
<210> 3287
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3287
uuugugggua gagucauaac 20
<210> 3288
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3288
uuuucagugu ggguuuaaag 20
<210> 3289
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3289
uuuuggcgua uguggguuug 20
<210> 3290
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3290
aaaaccucua aaccucaaau c 21
<210> 3291
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3291
aaaauugcaa guccccaagc u 21
<210> 3292
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3292
aaacacccaa acucucaggc a 21
<210> 3293
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3293
aaacacccaa augcacccug a 21
<210> 3294
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3294
aaacacccaa cccauaaaca c 21
<210> 3295
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3295
aaacacucaa acucccggac a 21
<210> 3296
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3296
aaacagggcu gguucugggg u 21
<210> 3297
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3297
aaacauccca aacuccaauu c 21
<210> 3298
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3298
aaaccaacag augaccucaa u 21
<210> 3299
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3299
aaacccacac augccccaaa c 21
<210> 3300
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3300
aaacccacac ugaaaauugc a 21
<210> 3301
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3301
aaacccacau acgccaaaac c 21
<210> 3302
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3302
aaacccagcc uaaaccucca a 21
<210> 3303
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3303
aaacccuaaa ccucuaccuc u 21
<210> 3304
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3304
aaacccugaa ccuuccaacc a 21
<210> 3305
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3305
aaaccucaaa ucuuagagca c 21
<210> 3306
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3306
aaaccuccaa caccccaguc c 21
<210> 3307
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3307
aaaccucuaa accucaaauc u 21
<210> 3308
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3308
aaaccucuac cucucuaaac a 21
<210> 3309
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3309
aaacucacag gcagcccaaa u 21
<210> 3310
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3310
aaacuccaau uccaccauac c 21
<210> 3311
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3311
aaacuccaau uccacgauac c 21
<210> 3312
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3312
aaacuccaau uccaugauac c 21
<210> 3313
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3313
aaacucccaa aucuuguaaa g 21
<210> 3314
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3314
aaacucccgg acacccucaa c 21
<210> 3315
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3315
aaacucucag gcagcccaaa u 21
<210> 3316
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3316
aaagauuggc uacuucgggu u 21
<210> 3317
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3317
aaagccuggg caacgagggg g 21
<210> 3318
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3318
aaaggccagg cccagcuggc u 21
<210> 3319
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3319
aaauacaauc aauuccaaau g 21
<210> 3320
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3320
aaauauguaa acacucaaac u 21
<210> 3321
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3321
aaaucuuaga gcaccccaaa c 21
<210> 3322
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3322
aaaucuugua aaguccaaac c 21
<210> 3323
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3323
aaaugcaccc ugaauucuac a 21
<210> 3324
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3324
aaaugcccca acuauacaug a 21
<210> 3325
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3325
aaaugucugc uuccacccca g 21
<210> 3326
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3326
aaauugcaag uccccaagcu g 21
<210> 3327
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3327
aacaccacau acacccuaaa c 21
<210> 3328
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3328
aacacccaaa cucucaggca g 21
<210> 3329
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3329
aacacccaaa ugcacccuga a 21
<210> 3330
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3330
aacacccaac ccauaaacac c 21
<210> 3331
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3331
aacaccccag uccuaauaaa u 21
<210> 3332
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3332
aacacucaaa cucccggaca c 21
<210> 3333
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3333
aacagaugac cucaauucua g 21
<210> 3334
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3334
aacagggcug guucuggggu g 21
<210> 3335
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3335
aacaucccaa acuccaauuc c 21
<210> 3336
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3336
aaccaacaga ugaccucaau u 21
<210> 3337
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3337
aaccacaugg gcaggacagc a 21
<210> 3338
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3338
aaccagcccu guuugugggu a 21
<210> 3339
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3339
aaccagcguc agcaacuccu c 21
<210> 3340
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3340
aacccacaca ugccccaaac c 21
<210> 3341
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3341
aacccacacu gaaaauugca a 21
<210> 3342
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3342
aacccacaua cgccaaaacc u 21
<210> 3343
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3343
aacccagccu aaaccuccaa c 21
<210> 3344
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3344
aacccauaaa cacccaaacu c 21
<210> 3345
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3345
aaccccugaa uccacaaaca c 21
<210> 3346
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3346
aacccgaagu agccaaucuu u 21
<210> 3347
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3347
aacccuaaac cucuaccucu c 21
<210> 3348
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3348
aacccugaac cuuccaacca g 21
<210> 3349
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3349
aaccgcacca ucaaugaaca c 21
<210> 3350
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3350
aaccucaaau cuuagagcac c 21
<210> 3351
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3351
aaccuccaac accccagucc u 21
<210> 3352
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3352
aaccucuaaa ccucaaaucu u 21
<210> 3353
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3353
aaccucuacc ucucuaaaca c 21
<210> 3354
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3354
aaccugcuaa ccccugaauc c 21
<210> 3355
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3355
aaccuuccaa ccagcgucag c 21
<210> 3356
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3356
aacgaggggg ccacacaucc c 21
<210> 3357
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3357
aacuauacau gaacccgaag u 21
<210> 3358
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3358
aacucacagg cagcccaaau a 21
<210> 3359
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3359
aacucacagg cagcccaaau g 21
<210> 3360
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3360
aacuccaauu ccaccauacc u 21
<210> 3361
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3361
aacuccaauu ccacgauacc u 21
<210> 3362
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3362
aacuccaauu ccaugauacc u 21
<210> 3363
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3363
aacucccaaa ucuuguaaag u 21
<210> 3364
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3364
aacucccgga cacccucaac u 21
<210> 3365
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3365
aacuccucca agucucugga c 21
<210> 3366
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3366
aacucuaccu acccaaaccc a 21
<210> 3367
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3367
aacucucagg cagcccaaau g 21
<210> 3368
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3368
aagauaaugg cauuggcaag u 21
<210> 3369
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3369
aagauuggcu acuucggguu c 21
<210> 3370
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3370
aagauuugag guuuagaggu u 21
<210> 3371
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3371
aagauuuggg aguuugcagc u 21
<210> 3372
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3372
aagcagacau uugggggucc a 21
<210> 3373
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3373
aagcccacuc ccgugcccca c 21
<210> 3374
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3374
aagccugggc aacgaggggg c 21
<210> 3375
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3375
aagcugcaaa cucccaaauc u 21
<210> 3376
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3376
aaggccaggc ccagcuggcu g 21
<210> 3377
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3377
aagguucagg guuugguggg a 21
<210> 3378
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3378
aaguagccaa ucuuuaaacc c 21
<210> 3379
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3379
aaguccagag acuuggagga g 21
<210> 3380
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3380
aaguccccaa gcugcaaacu c 21
<210> 3381
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3381
aagucucugg acuuccagac c 21
<210> 3382
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3382
aagugcgccg gcagucacug g 21
<210> 3383
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3383
aauacaauca auuccaaaug c 21
<210> 3384
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3384
aauauguaaa cacucaaacu c 21
<210> 3385
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3385
aaucaauucc aaaugcccca a 21
<210> 3386
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3386
aaucauuccc aaccugcuaa c 21
<210> 3387
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3387
aauccacaaa cacccaaaug c 21
<210> 3388
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3388
aauccaggua ucauggaauu g 21
<210> 3389
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3389
aauccaggua ucguggaauu g 21
<210> 3390
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3390
aauccaggua ugguggaauu g 21
<210> 3391
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3391
aaucgccuaa acccacacau g 21
<210> 3392
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3392
aaucuuagag caccccaaac c 21
<210> 3393
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3393
aaucuuguaa aguccaaacc u 21
<210> 3394
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3394
aaucuuuaaa cccacacuga a 21
<210> 3395
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3395
aaugaacacc acauacaccc u 21
<210> 3396
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3396
aaugacaagc ccacucccgu g 21
<210> 3397
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3397
aaugauuaua uauauuuggg c 21
<210> 3398
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3398
aaugcacccu gaauucuaca g 21
<210> 3399
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3399
aaugccauua ucuucucugg g 21
<210> 3400
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3400
aaugccccaa cuauacauga a 21
<210> 3401
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3401
aauggcauug gcaagugcgc c 21
<210> 3402
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3402
aaugucugcu uccaccccag a 21
<210> 3403
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3403
aauucagggu gcauuugggu g 21
<210> 3404
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3404
aauuccaaau gccccaacua u 21
<210> 3405
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3405
aauuccacca uaccuggauu c 21
<210> 3406
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3406
aauuccacga uaccuggauu c 21
<210> 3407
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3407
aauuccauga uaccuggauu c 21
<210> 3408
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3408
aauucuacag ggaccuggac c 21
<210> 3409
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3409
aauucuagaa acaucccaaa c 21
<210> 3410
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3410
aauugagguc aucuguuggu u 21
<210> 3411
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3411
aauugauugu auuuauuagg a 21
<210> 3412
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3412
aauugcaagu ccccaagcug c 21
<210> 3413
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3413
aauuggaguu ugggauguuu c 21
<210> 3414
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3414
aauuuucagu guggguuuaa a 21
<210> 3415
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3415
acaaacaccc aaaugcaccc u 21
<210> 3416
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3416
acaaacaccc aacccauaaa c 21
<210> 3417
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3417
acaaacaggg cugguucugg g 21
<210> 3418
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3418
acaagauuug ggaguuugca g 21
<210> 3419
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3419
acaagcccac ucccgugccc c 21
<210> 3420
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3420
acaaucaauu ccaaaugccc c 21
<210> 3421
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3421
acaaucgccu aaacccacac a 21
<210> 3422
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3422
acacagccug ccaggcgcug a 21
<210> 3423
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3423
acacauccca ccaaacccug a 21
<210> 3424
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3424
acacaugccc caaacccuaa a 21
<210> 3425
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3425
acaccacaua cacccuaaac c 21
<210> 3426
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3426
acacccaaac ucucaggcag c 21
<210> 3427
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3427
acacccaacc cauaaacacc c 21
<210> 3428
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3428
acaccccagu ccuaauaaau a 21
<210> 3429
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3429
acacccuaaa ccaacagaug a 21
<210> 3430
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3430
acacccucaa cucuaccuac c 21
<210> 3431
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3431
acacucaaac ucccggacac c 21
<210> 3432
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3432
acacuccaaa uauguaaaca c 21
<210> 3433
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3433
acacugaaaa uugcaagucc c 21
<210> 3434
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3434
acagaugacc ucaauucuag a 21
<210> 3435
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3435
acagcagcca ccaugacucc c 21
<210> 3436
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3436
acagccugcc aggcgcugac u 21
<210> 3437
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3437
acaggcagcc caaauauaua u 21
<210> 3438
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3438
acaggcagcc caaauguaua u 21
<210> 3439
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3439
acagggaccu ggacccccaa a 21
<210> 3440
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3440
acagggcugg uucuggggug g 21
<210> 3441
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3441
acauacaccc uaaaccaaca g 21
<210> 3442
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3442
acauacgcca aaaccucuaa a 21
<210> 3443
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3443
acauauuugg aguguuuaga g 21
<210> 3444
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3444
acaucccaaa cuccaauucc a 21
<210> 3445
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3445
acaucccacc aaacccugaa c 21
<210> 3446
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3446
acauccgugg aaugacaagc c 21
<210> 3447
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3447
acaugaaccc gaaguagcca a 21
<210> 3448
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3448
acaugcccca aacccuaaac c 21
<210> 3449
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3449
acaugggcag gacagcagcc a 21
<210> 3450
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3450
acauuugggc ugccugagag u 21
<210> 3451
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3451
acauuugggc ugccugugag u 21
<210> 3452
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3452
acauuugggg guccaggucc c 21
<210> 3453
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3453
accaaacccu gaaccuucca a 21
<210> 3454
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3454
accaacagau gaccucaauu c 21
<210> 3455
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3455
accacauaca cccuaaacca a 21
<210> 3456
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3456
accacauggg caggacagca g 21
<210> 3457
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3457
accagaggcu ggggcacaca g 21
<210> 3458
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3458
accagcccug uuugugggua g 21
<210> 3459
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3459
accagcguca gcaacuccuc c 21
<210> 3460
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3460
accauaccug gauuccacaa a 21
<210> 3461
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3461
accaucaaug aacaccacau a 21
<210> 3462
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3462
accaugacuc ccacucucag c 21
<210> 3463
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3463
acccaaaccc acauacgcca a 21
<210> 3464
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3464
acccaaacuc acaggcagcc c 21
<210> 3465
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3465
acccaaacuc ucaggcagcc c 21
<210> 3466
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3466
acccaaaugc acccugaauu c 21
<210> 3467
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3467
acccaaccca uaaacaccca a 21
<210> 3468
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3468
acccacaaac agggcugguu c 21
<210> 3469
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3469
acccacaauc gccuaaaccc a 21
<210> 3470
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3470
acccacacau gccccaaacc c 21
<210> 3471
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3471
acccacacug aaaauugcaa g 21
<210> 3472
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3472
acccacauac gccaaaaccu c 21
<210> 3473
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3473
acccagccua aaccuccaac a 21
<210> 3474
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3474
acccauaaac acccaaacuc u 21
<210> 3475
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3475
accccaaacc cagccuaaac c 21
<210> 3476
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3476
accccagaac cagcccuguu u 21
<210> 3477
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3477
accccagucc uaauaaauac a 21
<210> 3478
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3478
acccccaaau gucugcuucc a 21
<210> 3479
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3479
acccccaacc gcaccaucaa u 21
<210> 3480
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3480
accccugaau ccacaaacac c 21
<210> 3481
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3481
acccgaagua gccaaucuuu a 21
<210> 3482
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3482
acccuaaacc aacagaugac c 21
<210> 3483
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3483
acccuaaacc ucuaccucuc u 21
<210> 3484
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3484
acccucaacu cuaccuaccc a 21
<210> 3485
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3485
acccugaacc uuccaaccag c 21
<210> 3486
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3486
acccugaauu cuacagggac c 21
<210> 3487
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3487
accgcaccau caaugaacac c 21
<210> 3488
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3488
accgucucaa ccacaugggc a 21
<210> 3489
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3489
accuacccaa acccacauac g 21
<210> 3490
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3490
accucaaauc uuagagcacc c 21
<210> 3491
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3491
accucaauuc uagaaacauc c 21
<210> 3492
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3492
accuccaaca ccccaguccu a 21
<210> 3493
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3493
accucuaaac cucaaaucuu a 21
<210> 3494
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3494
accucuaccu cucuaaacac u 21
<210> 3495
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3495
accucucuaa acacuccaaa u 21
<210> 3496
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3496
accugcuaac cccugaaucc a 21
<210> 3497
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3497
accuggaccc ccaaaugucu g 21
<210> 3498
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3498
accuggauuc cacaaacacc c 21
<210> 3499
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3499
accuuccaac cagcgucagc a 21
<210> 3500
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3500
acgagggggc cacacauccc a 21
<210> 3501
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3501
acgauaccug gauuccacaa a 21
<210> 3502
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3502
acgccaaaac cucuaaaccu c 21
<210> 3503
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3503
acgccagucc ucacuggagu c 21
<210> 3504
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3504
acgcugguug gaagguucag g 21
<210> 3505
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3505
acggauguga gacgccaguc c 21
<210> 3506
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3506
acgggagugg gcuugucauu c 21
<210> 3507
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3507
acgguggcag ugcccagaga a 21
<210> 3508
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3508
acuauacaug aacccgaagu a 21
<210> 3509
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3509
acucaaacuc ccggacaccc u 21
<210> 3510
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3510
acucacaggc agcccaaaua u 21
<210> 3511
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3511
acucacaggc agcccaaaug u 21
<210> 3512
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3512
acuccaaaua uguaaacacu c 21
<210> 3513
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3513
acuccaauuc caccauaccu g 21
<210> 3514
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3514
acuccaauuc cacgauaccu g 21
<210> 3515
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3515
acuccaauuc caugauaccu g 21
<210> 3516
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3516
acuccaguga ggacuggcgu c 21
<210> 3517
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3517
acucccaaau cuuguaaagu c 21
<210> 3518
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3518
acucccacuc ucagccagcu g 21
<210> 3519
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3519
acucccggac acccucaacu c 21
<210> 3520
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3520
acuccuccaa gucucuggac u 21
<210> 3521
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3521
acucggaggu uuggacuuua c 21
<210> 3522
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3522
acucuaccca caaacagggc u 21
<210> 3523
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3523
acucuaccua cccaaaccca c 21
<210> 3524
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3524
acucucagcc agcugggccu g 21
<210> 3525
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3525
acucucaggc agcccaaaug u 21
<210> 3526
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3526
acugaaaauu gcaagucccc a 21
<210> 3527
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3527
acugccaccg ucucaaccac a 21
<210> 3528
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3528
acugccggcg cacuugccaa u 21
<210> 3529
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3529
acuggaguca gcgccuggca g 21
<210> 3530
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3530
acuggauccu cuccaggacc a 21
<210> 3531
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3531
acuggcgucu cacauccgug g 21
<210> 3532
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3532
acuggggugu uggagguuua g 21
<210> 3533
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3533
acuuccagac ccacaaucgc c 21
<210> 3534
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3534
acuucggguu cauguauagu u 21
<210> 3535
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3535
acuugcaauu uucagugugg g 21
<210> 3536
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3536
acuugccaau gccauuaucu u 21
<210> 3537
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3537
acuuggagga guugcugacg c 21
<210> 3538
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3538
acuuuacaag auuugggagu u 21
<210> 3539
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3539
agaaacaucc caaacuccaa u 21
<210> 3540
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3540
agaaccagcc cuguuugugg g 21
<210> 3541
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3541
agaagauaau ggcauuggca a 21
<210> 3542
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3542
agaauucagg gugcauuugg g 21
<210> 3543
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3543
agaauugagg ucaucuguug g 21
<210> 3544
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3544
agacauuugg ggguccaggu c 21
<210> 3545
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3545
agacccacaa ucgccuaaac c 21
<210> 3546
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3546
agacgccagu ccucacugga g 21
<210> 3547
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3547
agacgguggc agugcccaga g 21
<210> 3548
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3548
agacucggag guuuggacuu u 21
<210> 3549
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3549
agacuuggag gaguugcuga c 21
<210> 3550
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3550
agagaagaua auggcauugg c 21
<210> 3551
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3551
agagacuugg aggaguugcu g 21
<210> 3552
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3552
agagagguag agguuuaggg u 21
<210> 3553
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3553
agagcacccc aaacccagcc u 21
<210> 3554
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3554
agaggaucca gugacugccg g 21
<210> 3555
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3555
agaggcuggg gcacacagcc u 21
<210> 3556
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3556
agagguagag guuuaggguu u 21
<210> 3557
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3557
agagguuuag gguuuggggc a 21
<210> 3558
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3558
agagguuuug gcguaugugg g 21
<210> 3559
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3559
agagugggag ucaugguggc u 21
<210> 3560
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3560
agaguugagg guguccggga g 21
<210> 3561
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3561
agaguuuggg uguuuauggg u 21
<210> 3562
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3562
agauaauggc auuggcaagu g 21
<210> 3563
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3563
agaugaccuc aauucuagaa a 21
<210> 3564
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3564
agauuggcua cuucggguuc a 21
<210> 3565
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3565
agauuugagg uuuagagguu u 21
<210> 3566
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3566
agauuuggga guuugcagcu u 21
<210> 3567
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3567
agcaacuccu ccaagucucu g 21
<210> 3568
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3568
agcaccccaa acccagccua a 21
<210> 3569
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3569
agcagacauu ugggggucca g 21
<210> 3570
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3570
agcagccacc augacuccca c 21
<210> 3571
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3571
agccaaucuu uaaacccaca c 21
<210> 3572
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3572
agccaccaug acucccacuc u 21
<210> 3573
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3573
agccagcugg gccuggccuu u 21
<210> 3574
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3574
agcccacucc cgugccccac u 21
<210> 3575
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3575
agcccuguuu guggguagag u 21
<210> 3576
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3576
agccuaaacc uccaacaccc c 21
<210> 3577
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3577
agccucuggu ccuggagagg a 21
<210> 3578
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3578
agccugccag gcgcugacuc c 21
<210> 3579
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3579
agccugggca acgagggggc c 21
<210> 3580
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3580
agcgccuggc aggcugugug c 21
<210> 3581
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3581
agcgucagca acuccuccaa g 21
<210> 3582
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3582
agcugcaaac ucccaaaucu u 21
<210> 3583
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3583
agcuggcuga gagugggagu c 21
<210> 3584
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3584
agcugggccu ggccuuugaa a 21
<210> 3585
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3585
agcuugggga cuugcaauuu u 21
<210> 3586
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3586
aggacagcag ccaccaugac u 21
<210> 3587
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3587
aggaccagag gcuggggcac a 21
<210> 3588
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3588
aggacuggcg ucucacaucc g 21
<210> 3589
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3589
aggacugggg uguuggaggu u 21
<210> 3590
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3590
aggaguugcu gacgcugguu g 21
<210> 3591
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3591
aggauccagu gacugccggc g 21
<210> 3592
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3592
aggcagccca aauauauaua a 21
<210> 3593
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3593
aggccaggcc cagcuggcug a 21
<210> 3594
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3594
aggcccagcu ggcugagagu g 21
<210> 3595
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3595
aggcgauugu gggucuggaa g 21
<210> 3596
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3596
aggcgcugac uccagugagg a 21
<210> 3597
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3597
aggcuggggc acacagccug c 21
<210> 3598
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3598
aggcuggguu uggggugcuc u 21
<210> 3599
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3599
aggcugugug ccccagccuc u 21
<210> 3600
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3600
aggcuuucaa aggccaggcc c 21
<210> 3601
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3601
agggaccugg acccccaaau g 21
<210> 3602
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3602
agggcugguu cuggggugga a 21
<210> 3603
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3603
agggggccac acaucccacc a 21
<210> 3604
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3604
agggguuagc agguugggaa u 21
<210> 3605
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3605
agggugcauu uggguguuug u 21
<210> 3606
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3606
aggguguaug ugguguucau u 21
<210> 3607
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3607
aggguguccg ggaguuugag u 21
<210> 3608
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3608
aggguuuggg gcaugugugg g 21
<210> 3609
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3609
aggguuuggu gggaugugug g 21
<210> 3610
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3610
agguagaggu uuaggguuug g 21
<210> 3611
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3611
agguagaguu gagggugucc g 21
<210> 3612
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3612
agguaucgug gaauuggagu u 21
<210> 3613
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3613
agguauggug gaauuggagu u 21
<210> 3614
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3614
aggucaucug uugguuuagg g 21
<210> 3615
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3615
aggucccugu agaauucagg g 21
<210> 3616
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3616
agguucaggg uuugguggga u 21
<210> 3617
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3617
agguuuagag guuuuggcgu a 21
<210> 3618
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3618
agguuuaggc uggguuuggg g 21
<210> 3619
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3619
agguuuaggg uuuggggcau g 21
<210> 3620
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3620
agguuuggac uuuacaagau u 21
<210> 3621
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3621
agguuuuggc guaugugggu u 21
<210> 3622
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3622
aguagccaau cuuuaaaccc a 21
<210> 3623
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3623
agucacugga uccucuccag g 21
<210> 3624
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3624
agucagcgcc uggcaggcug u 21
<210> 3625
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3625
agucauggug gcugcugucc u 21
<210> 3626
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3626
aguccagaga cuuggaggag u 21
<210> 3627
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3627
aguccccaag cugcaaacuc c 21
<210> 3628
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3628
aguccucacu ggagucagcg c 21
<210> 3629
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3629
agucucugga cuuccagacc c 21
<210> 3630
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3630
agugacugcc ggcgcacuug c 21
<210> 3631
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3631
agugaggacu ggcgucucac a 21
<210> 3632
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3632
agugcccaga gaagauaaug g 21
<210> 3633
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3633
agugcgccgg cagucacugg a 21
<210> 3634
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3634
agugggaguc augguggcug c 21
<210> 3635
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3635
agugggcuug ucauuccacg g 21
<210> 3636
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3636
aguggggcac gggagugggc u 21
<210> 3637
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3637
agugguuaug acucuaccca c 21
<210> 3638
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3638
aguguggguu uaaagauugg c 21
<210> 3639
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3639
aguguuuaga gagguagagg u 21
<210> 3640
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3640
aguugagggu guccgggagu u 21
<210> 3641
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3641
aguugcugac gcugguugga a 21
<210> 3642
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3642
aguuggggca uuuggaauug a 21
<210> 3643
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3643
aguuuauaua cauuugggcu g 21
<210> 3644
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3644
aguuugagug uuuacauauu u 21
<210> 3645
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3645
aguuugcagc uuggggacuu g 21
<210> 3646
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3646
aguuugggau guuucuagaa u 21
<210> 3647
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3647
aguuugggug uuuauggguu g 21
<210> 3648
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3648
auaaacaccc aaacucucag g 21
<210> 3649
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3649
auaaacucca auuccacgau a 21
<210> 3650
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3650
auaaacucca auuccaugau a 21
<210> 3651
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3651
auaaauacaa ucaauuccaa a 21
<210> 3652
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3652
auaaucauuc ccaaccugcu a 21
<210> 3653
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3653
auaauggcau uggcaagugc g 21
<210> 3654
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3654
auacaaucaa uuccaaaugc c 21
<210> 3655
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3655
auacacccua aaccaacaga u 21
<210> 3656
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3656
auacaugaac ccgaaguagc c 21
<210> 3657
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3657
auacauuugg gcugccugag a 21
<210> 3658
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3658
auacauuugg gcugccugug a 21
<210> 3659
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3659
auacgccaaa accucuaaac c 21
<210> 3660
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3660
auaguugggg cauuuggaau u 21
<210> 3661
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3661
auauaaacuc caauuccacg a 21
<210> 3662
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3662
auauaaacuc caauuccaug a 21
<210> 3663
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3663
auauaaucau ucccaaccug c 21
<210> 3664
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3664
auauacauuu gggcugccug a 21
<210> 3665
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3665
auauacauuu gggcugccug u 21
<210> 3666
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3666
auauauaauc auucccaacc u 21
<210> 3667
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3667
auauauauuu gggcugccug u 21
<210> 3668
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3668
auauauuugg gcugccugug a 21
<210> 3669
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3669
auauguaaac acucaaacuc c 21
<210> 3670
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3670
auauuuggag uguuuagaga g 21
<210> 3671
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3671
auauuugggc ugccugugag u 21
<210> 3672
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3672
aucaaugaac accacauaca c 21
<210> 3673
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3673
aucaauucca aaugccccaa c 21
<210> 3674
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3674
aucauuccca accugcuaac c 21
<210> 3675
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3675
auccacaaac acccaaaugc a 21
<210> 3676
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3676
auccagguau cauggaauug g 21
<210> 3677
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3677
auccagguau cguggaauug g 21
<210> 3678
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3678
auccagguau gguggaauug g 21
<210> 3679
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3679
auccagugac ugccggcgca c 21
<210> 3680
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3680
aucccaaacu ccaauuccac c 21
<210> 3681
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3681
aucccaccaa acccugaacc u 21
<210> 3682
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3682
auccguggaa ugacaagccc a 21
<210> 3683
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3683
auccucucca ggaccagagg c 21
<210> 3684
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3684
aucgccuaaa cccacacaug c 21
<210> 3685
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3685
aucuguuggu uuagggugua u 21
<210> 3686
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3686
aucuuagagc accccaaacc c 21
<210> 3687
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3687
aucuucucug ggcacugcca c 21
<210> 3688
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3688
aucuuguaaa guccaaaccu c 21
<210> 3689
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3689
aucuuuaaac ccacacugaa a 21
<210> 3690
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3690
augaacacca cauacacccu a 21
<210> 3691
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3691
augaacccga aguagccaau c 21
<210> 3692
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3692
augacaagcc cacucccgug c 21
<210> 3693
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3693
augaccucaa uucuagaaac a 21
<210> 3694
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3694
augacuccca cucucagcca g 21
<210> 3695
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3695
augacucuac ccacaaacag g 21
<210> 3696
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3696
augauaccug gauuccacaa a 21
<210> 3697
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3697
augauuauau auauuugggc u 21
<210> 3698
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3698
augcacccug aauucuacag g 21
<210> 3699
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3699
augccauuau cuucucuggg c 21
<210> 3700
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3700
augccccaaa cccuaaaccu c 21
<210> 3701
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3701
augccccaac uauacaugaa c 21
<210> 3702
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3702
auggcauugg caagugcgcc g 21
<210> 3703
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3703
augggcagga cagcagccac c 21
<210> 3704
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3704
auggguuggg uguuugugga a 21
<210> 3705
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3705
augguggaau uggaguuugg g 21
<210> 3706
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3706
augguggcug cuguccugcc c 21
<210> 3707
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3707
auguaaacac ucaaacuccc g 21
<210> 3708
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3708
auguauaguu ggggcauuug g 21
<210> 3709
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3709
augucugcuu ccaccccaga a 21
<210> 3710
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3710
augugagacg ccaguccuca c 21
<210> 3711
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3711
auguggguuu ggguagguag a 21
<210> 3712
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3712
augugguguu cauugauggu g 21
<210> 3713
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3713
augugguuga gacgguggca g 21
<210> 3714
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3714
auguguggcc cccucguugc c 21
<210> 3715
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3715
augugugggu uuaggcgauu g 21
<210> 3716
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3716
auguuucuag aauugagguc a 21
<210> 3717
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3717
auuaggacug ggguguugga g 21
<210> 3718
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3718
auuauauaua uuugggcugc c 21
<210> 3719
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3719
auuaucuucu cugggcacug c 21
<210> 3720
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3720
auucaggggu uagcagguug g 21
<210> 3721
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3721
auucagggug cauuugggug u 21
<210> 3722
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3722
auuccaaaug ccccaacuau a 21
<210> 3723
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3723
auuccacaaa cacccaaccc a 21
<210> 3724
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3724
auuccaccau accuggauuc c 21
<210> 3725
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3725
auuccacgau accuggauuc c 21
<210> 3726
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3726
auuccacgga ugugagacgc c 21
<210> 3727
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3727
auuccaugau accuggauuc c 21
<210> 3728
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3728
auucccaacc ugcuaacccc u 21
<210> 3729
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3729
auucuacagg gaccuggacc c 21
<210> 3730
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3730
auucuagaaa caucccaaac u 21
<210> 3731
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3731
auugagguca ucuguugguu u 21
<210> 3732
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3732
auugauugua uuuauuagga c 21
<210> 3733
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3733
auugcaaguc cccaagcugc a 21
<210> 3734
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3734
auuggaguuu gggauguuuc u 21
<210> 3735
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3735
auuggcaagu gcgccggcag u 21
<210> 3736
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3736
auuggcuacu ucggguucau g 21
<210> 3737
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3737
auuguauuua uuaggacugg g 21
<210> 3738
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3738
auuguggguc uggaagucca g 21
<210> 3739
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3739
auuuauuagg acuggggugu u 21
<210> 3740
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3740
auuugagguu uagagguuuu g 21
<210> 3741
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3741
auuuggagug uuuagagagg u 21
<210> 3742
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3742
auuugggagu uugcagcuug g 21
<210> 3743
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3743
auuugggcug ccugagaguu u 21
<210> 3744
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3744
auuugggggu ccaggucccu g 21
<210> 3745
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3745
auuugggugu uuguggauuc a 21
<210> 3746
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3746
auuuucagug uggguuuaaa g 21
<210> 3747
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3747
caaaaccucu aaaccucaaa u 21
<210> 3748
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3748
caaacaccca aaugcacccu g 21
<210> 3749
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3749
caaacaccca acccauaaac a 21
<210> 3750
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3750
caaacagggc ugguucuggg g 21
<210> 3751
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3751
caaacccaca uacgccaaaa c 21
<210> 3752
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3752
caaacccagc cuaaaccucc a 21
<210> 3753
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3753
caaacccuaa accucuaccu c 21
<210> 3754
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3754
caaacccuga accuuccaac c 21
<210> 3755
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3755
caaacucaca ggcagcccaa a 21
<210> 3756
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3756
caaacuccaa uuccaccaua c 21
<210> 3757
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3757
caaacuccca aaucuuguaa a 21
<210> 3758
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3758
caaacucccg gacacccuca a 21
<210> 3759
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3759
caaacucuca ggcagcccaa a 21
<210> 3760
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3760
caaaggccag gcccagcugg c 21
<210> 3761
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3761
caaauaugua aacacucaaa c 21
<210> 3762
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3762
caaaucuuag agcaccccaa a 21
<210> 3763
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3763
caaaucuugu aaaguccaaa c 21
<210> 3764
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3764
caaaugcacc cugaauucua c 21
<210> 3765
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3765
caaaugcccc aacuauacau g 21
<210> 3766
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3766
caaauguaua uaaacuccaa u 21
<210> 3767
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3767
caaaugucug cuuccacccc a 21
<210> 3768
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3768
caacacccca guccuaauaa a 21
<210> 3769
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3769
caacagauga ccucaauucu a 21
<210> 3770
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3770
caaccacaug ggcaggacag c 21
<210> 3771
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3771
caaccagcgu cagcaacucc u 21
<210> 3772
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3772
caacccauaa acacccaaac u 21
<210> 3773
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3773
caaccgcacc aucaaugaac a 21
<210> 3774
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3774
caaccugcua accccugaau c 21
<210> 3775
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3775
caacgagggg gccacacauc c 21
<210> 3776
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3776
caacuauaca ugaacccgaa g 21
<210> 3777
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3777
caacuccucc aagucucugg a 21
<210> 3778
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3778
caacucuacc uacccaaacc c 21
<210> 3779
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3779
caagauuugg gaguuugcag c 21
<210> 3780
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3780
caagcccacu cccgugcccc a 21
<210> 3781
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3781
caagcugcaa acucccaaau c 21
<210> 3782
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3782
caagucccca agcugcaaac u 21
<210> 3783
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3783
caagucucug gacuuccaga c 21
<210> 3784
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3784
caagugcgcc ggcagucacu g 21
<210> 3785
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3785
caaucaauuc caaaugcccc a 21
<210> 3786
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3786
caaucgccua aacccacaca u 21
<210> 3787
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3787
caaucuuuaa acccacacug a 21
<210> 3788
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3788
caaugaacac cacauacacc c 21
<210> 3789
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3789
caaugccauu aucuucucug g 21
<210> 3790
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3790
caauuccaaa ugccccaacu a 21
<210> 3791
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3791
caauuccacc auaccuggau u 21
<210> 3792
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3792
caauuccacg auaccuggau u 21
<210> 3793
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3793
caauuccaug auaccuggau u 21
<210> 3794
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3794
caauucuaga aacaucccaa a 21
<210> 3795
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3795
caauuuucag uguggguuua a 21
<210> 3796
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3796
cacaaacacc caaaugcacc c 21
<210> 3797
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3797
cacaaacacc caacccauaa a 21
<210> 3798
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3798
cacaaacagg gcugguucug g 21
<210> 3799
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3799
cacaaucgcc uaaacccaca c 21
<210> 3800
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3800
cacacagccu gccaggcgcu g 21
<210> 3801
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3801
cacacauccc accaaacccu g 21
<210> 3802
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3802
cacacaugcc ccaaacccua a 21
<210> 3803
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3803
cacacugaaa auugcaaguc c 21
<210> 3804
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3804
cacagccugc caggcgcuga c 21
<210> 3805
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3805
cacaggcagc ccaaauauau a 21
<210> 3806
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3806
cacaggcagc ccaaauguau a 21
<210> 3807
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3807
cacauacacc cuaaaccaac a 21
<210> 3808
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3808
cacauacgcc aaaaccucua a 21
<210> 3809
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3809
cacaucccac caaacccuga a 21
<210> 3810
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3810
cacauccgug gaaugacaag c 21
<210> 3811
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3811
cacaugcccc aaacccuaaa c 21
<210> 3812
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3812
cacaugggca ggacagcagc c 21
<210> 3813
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3813
caccaaaccc ugaaccuucc a 21
<210> 3814
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3814
caccacauac acccuaaacc a 21
<210> 3815
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3815
caccauaccu ggauuccaca a 21
<210> 3816
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3816
caccaucaau gaacaccaca u 21
<210> 3817
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3817
caccaugacu cccacucuca g 21
<210> 3818
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3818
cacccaaacu cacaggcagc c 21
<210> 3819
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3819
cacccaaacu cucaggcagc c 21
<210> 3820
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3820
cacccaaaug cacccugaau u 21
<210> 3821
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3821
cacccaaccc auaaacaccc a 21
<210> 3822
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3822
caccccaaac ccagccuaaa c 21
<210> 3823
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3823
caccccagaa ccagcccugu u 21
<210> 3824
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3824
caccccaguc cuaauaaaua c 21
<210> 3825
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3825
cacccuaaac caacagauga c 21
<210> 3826
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3826
cacccucaac ucuaccuacc c 21
<210> 3827
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3827
cacccugaau ucuacaggga c 21
<210> 3828
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3828
caccgucuca accacauggg c 21
<210> 3829
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3829
cacgauaccu ggauuccaca a 21
<210> 3830
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3830
cacggaugug agacgccagu c 21
<210> 3831
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3831
cacgggagug ggcuugucau u 21
<210> 3832
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3832
cacucaaacu cccggacacc c 21
<210> 3833
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3833
cacuccaaau auguaaacac u 21
<210> 3834
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3834
cacucucagc cagcugggcc u 21
<210> 3835
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3835
cacugaaaau ugcaaguccc c 21
<210> 3836
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3836
cacugccacc gucucaacca c 21
<210> 3837
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3837
cacuggaguc agcgccuggc a 21
<210> 3838
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3838
cacuggaucc ucuccaggac c 21
<210> 3839
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3839
cacuugccaa ugccauuauc u 21
<210> 3840
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3840
cagaaccagc ccuguuugug g 21
<210> 3841
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3841
cagacauuug gggguccagg u 21
<210> 3842
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3842
cagacccaca aucgccuaaa c 21
<210> 3843
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3843
cagagaagau aauggcauug g 21
<210> 3844
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3844
cagagacuug gaggaguugc u 21
<210> 3845
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3845
cagaggcugg ggcacacagc c 21
<210> 3846
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3846
cagaugaccu caauucuaga a 21
<210> 3847
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3847
cagcaacucc uccaagucuc u 21
<210> 3848
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3848
cagcagccac caugacuccc a 21
<210> 3849
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3849
cagccaccau gacucccacu c 21
<210> 3850
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3850
cagccagcug ggccuggccu u 21
<210> 3851
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3851
cagcccaaau auauauaauc a 21
<210> 3852
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3852
cagcccuguu uguggguaga g 21
<210> 3853
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3853
cagccuaaac cuccaacacc c 21
<210> 3854
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3854
cagccucugg uccuggagag g 21
<210> 3855
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3855
cagccugcca ggcgcugacu c 21
<210> 3856
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3856
cagcgccugg caggcugugu g 21
<210> 3857
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3857
cagcgucagc aacuccucca a 21
<210> 3858
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3858
cagcuggcug agagugggag u 21
<210> 3859
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3859
cagcugggcc uggccuuuga a 21
<210> 3860
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3860
cagcuugggg acuugcaauu u 21
<210> 3861
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3861
caggacagca gccaccauga c 21
<210> 3862
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3862
caggaccaga ggcuggggca c 21
<210> 3863
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3863
caggcagccc aaauauauau a 21
<210> 3864
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3864
caggcccagc uggcugagag u 21
<210> 3865
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3865
caggcgcuga cuccagugag g 21
<210> 3866
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3866
caggcugugu gccccagccu c 21
<210> 3867
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3867
caggcuuuca aaggccaggc c 21
<210> 3868
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3868
cagggaccug gacccccaaa u 21
<210> 3869
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3869
cagggcuggu ucuggggugg a 21
<210> 3870
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3870
cagggguuag cagguuggga a 21
<210> 3871
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3871
cagggugcau uuggguguuu g 21
<210> 3872
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3872
caggguuugg ugggaugugu g 21
<210> 3873
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3873
cagguaucau ggaauuggag u 21
<210> 3874
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3874
cagguaucgu ggaauuggag u 21
<210> 3875
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3875
cagguauggu ggaauuggag u 21
<210> 3876
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3876
caggucccug uagaauucag g 21
<210> 3877
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3877
cagucacugg auccucucca g 21
<210> 3878
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3878
caguccucac uggagucagc g 21
<210> 3879
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3879
cagugacugc cggcgcacuu g 21
<210> 3880
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3880
cagugaggac uggcgucuca c 21
<210> 3881
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3881
cagugcccag agaagauaau g 21
<210> 3882
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3882
cagugugggu uuaaagauug g 21
<210> 3883
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3883
cauaaacacc caaacucuca g 21
<210> 3884
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3884
cauacacccu aaaccaacag a 21
<210> 3885
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3885
cauaccugga uuccacaaac a 21
<210> 3886
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3886
cauacgccaa aaccucuaaa c 21
<210> 3887
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3887
cauauuugga guguuuagag a 21
<210> 3888
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3888
caucaaugaa caccacauac a 21
<210> 3889
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3889
caucccaaac uccaauucca c 21
<210> 3890
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3890
caucccacca aacccugaac c 21
<210> 3891
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3891
cauccgugga augacaagcc c 21
<210> 3892
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3892
caucuguugg uuuagggugu a 21
<210> 3893
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3893
caugaacccg aaguagccaa u 21
<210> 3894
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3894
caugacuccc acucucagcc a 21
<210> 3895
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3895
caugauaccu ggauuccaca a 21
<210> 3896
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3896
caugccccaa acccuaaacc u 21
<210> 3897
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3897
caugggcagg acagcagcca c 21
<210> 3898
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3898
caugguggcu gcuguccugc c 21
<210> 3899
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3899
cauguauagu uggggcauuu g 21
<210> 3900
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3900
caugugguug agacgguggc a 21
<210> 3901
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3901
cauguguggg uuuaggcgau u 21
<210> 3902
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3902
cauuaucuuc ucugggcacu g 21
<210> 3903
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3903
cauuccacgg augugagacg c 21
<210> 3904
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3904
cauucccaac cugcuaaccc c 21
<210> 3905
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3905
cauuggcaag ugcgccggca g 21
<210> 3906
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3906
cauuugggcu gccugagagu u 21
<210> 3907
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3907
cauuugggcu gccugugagu u 21
<210> 3908
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3908
cauuuggggg uccagguccc u 21
<210> 3909
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3909
cauuugggug uuuguggauu c 21
<210> 3910
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3910
ccaaaaccuc uaaaccucaa a 21
<210> 3911
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3911
ccaaacccac auacgccaaa a 21
<210> 3912
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3912
ccaaacccag ccuaaaccuc c 21
<210> 3913
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3913
ccaaacccua aaccucuacc u 21
<210> 3914
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3914
ccaaacccug aaccuuccaa c 21
<210> 3915
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3915
ccaaacucac aggcagccca a 21
<210> 3916
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3916
ccaaacucca auuccaccau a 21
<210> 3917
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3917
ccaaacucuc aggcagccca a 21
<210> 3918
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3918
ccaaauaugu aaacacucaa a 21
<210> 3919
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3919
ccaaaucuug uaaaguccaa a 21
<210> 3920
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3920
ccaaaugcac ccugaauucu a 21
<210> 3921
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3921
ccaaaugccc caacuauaca u 21
<210> 3922
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3922
ccaaauguau auaaacucca a 21
<210> 3923
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3923
ccaaaugucu gcuuccaccc c 21
<210> 3924
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3924
ccaacacccc aguccuaaua a 21
<210> 3925
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3925
ccaacagaug accucaauuc u 21
<210> 3926
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3926
ccaaccagcg ucagcaacuc c 21
<210> 3927
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3927
ccaacccaua aacacccaaa c 21
<210> 3928
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3928
ccaaccgcac caucaaugaa c 21
<210> 3929
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3929
ccaaccugcu aaccccugaa u 21
<210> 3930
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3930
ccaacuauac augaacccga a 21
<210> 3931
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3931
ccaagcugca aacucccaaa u 21
<210> 3932
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3932
ccaagucucu ggacuuccag a 21
<210> 3933
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3933
ccaaucuuua aacccacacu g 21
<210> 3934
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3934
ccaaugccau uaucuucucu g 21
<210> 3935
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3935
ccaauuccac cauaccugga u 21
<210> 3936
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3936
ccaauuccac gauaccugga u 21
<210> 3937
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3937
ccaauuccau gauaccugga u 21
<210> 3938
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3938
ccacaaacac ccaaaugcac c 21
<210> 3939
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3939
ccacaaacac ccaacccaua a 21
<210> 3940
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3940
ccacaaacag ggcugguucu g 21
<210> 3941
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3941
ccacaaucgc cuaaacccac a 21
<210> 3942
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3942
ccacacaucc caccaaaccc u 21
<210> 3943
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3943
ccacacaugc cccaaacccu a 21
<210> 3944
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3944
ccacacugaa aauugcaagu c 21
<210> 3945
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3945
ccacauacac ccuaaaccaa c 21
<210> 3946
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3946
ccacauacgc caaaaccucu a 21
<210> 3947
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3947
ccacaugggc aggacagcag c 21
<210> 3948
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3948
ccaccaaacc cugaaccuuc c 21
<210> 3949
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3949
ccaccauacc uggauuccac a 21
<210> 3950
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3950
ccaccaugac ucccacucuc a 21
<210> 3951
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3951
ccaccccaga accagcccug u 21
<210> 3952
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3952
ccaccgucuc aaccacaugg g 21
<210> 3953
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3953
ccacgauacc uggauuccac a 21
<210> 3954
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3954
ccacggaugu gagacgccag u 21
<210> 3955
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3955
ccacucucag ccagcugggc c 21
<210> 3956
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3956
ccagaaccag cccuguuugu g 21
<210> 3957
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3957
ccagacccac aaucgccuaa a 21
<210> 3958
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3958
ccagagaaga uaauggcauu g 21
<210> 3959
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3959
ccagagacuu ggaggaguug c 21
<210> 3960
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3960
ccagaggcug gggcacacag c 21
<210> 3961
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3961
ccagcccugu uuguggguag a 21
<210> 3962
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3962
ccagccuaaa ccuccaacac c 21
<210> 3963
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3963
ccagccucug guccuggaga g 21
<210> 3964
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3964
ccagcgucag caacuccucc a 21
<210> 3965
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3965
ccagcuggcu gagaguggga g 21
<210> 3966
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3966
ccagcugggc cuggccuuug a 21
<210> 3967
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3967
ccaggaccag aggcuggggc a 21
<210> 3968
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3968
ccaggcccag cuggcugaga g 21
<210> 3969
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3969
ccaggcgcug acuccaguga g 21
<210> 3970
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3970
ccaggcuuuc aaaggccagg c 21
<210> 3971
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3971
ccagguauca uggaauugga g 21
<210> 3972
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3972
ccagguaucg uggaauugga g 21
<210> 3973
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3973
ccagguaugg uggaauugga g 21
<210> 3974
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3974
ccaggucccu guagaauuca g 21
<210> 3975
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3975
ccaguccuaa uaaauacaau c 21
<210> 3976
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3976
ccaguccuca cuggagucag c 21
<210> 3977
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3977
ccagugacug ccggcgcacu u 21
<210> 3978
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3978
ccagugagga cuggcgucuc a 21
<210> 3979
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3979
ccauaaacac ccaaacucuc a 21
<210> 3980
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3980
ccauaccugg auuccacaaa c 21
<210> 3981
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3981
ccaucaauga acaccacaua c 21
<210> 3982
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3982
ccaugacucc cacucucagc c 21
<210> 3983
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3983
ccaugauacc uggauuccac a 21
<210> 3984
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3984
ccaugugguu gagacggugg c 21
<210> 3985
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3985
ccauuaucuu cucugggcac u 21
<210> 3986
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3986
cccaaaccca cauacgccaa a 21
<210> 3987
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3987
cccaaaccca gccuaaaccu c 21
<210> 3988
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3988
cccaaacccu aaaccucuac c 21
<210> 3989
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3989
cccaaacuca caggcagccc a 21
<210> 3990
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3990
cccaaacucc aauuccacca u 21
<210> 3991
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3991
cccaaacucu caggcagccc a 21
<210> 3992
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3992
cccaaauaua uauaaucauu c 21
<210> 3993
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3993
cccaaaucuu guaaagucca a 21
<210> 3994
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3994
cccaaaugca cccugaauuc u 21
<210> 3995
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3995
cccaaauguc ugcuuccacc c 21
<210> 3996
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3996
cccaacccau aaacacccaa a 21
<210> 3997
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3997
cccaaccgca ccaucaauga a 21
<210> 3998
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3998
cccaaccugc uaaccccuga a 21
<210> 3999
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 3999
cccaacuaua caugaacccg a 21
<210> 4000
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4000
cccaagcugc aaacucccaa a 21
<210> 4001
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4001
cccacaaaca gggcugguuc u 21
<210> 4002
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4002
cccacaaucg ccuaaaccca c 21
<210> 4003
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4003
cccacacaug ccccaaaccc u 21
<210> 4004
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4004
cccacacuga aaauugcaag u 21
<210> 4005
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4005
cccacauacg ccaaaaccuc u 21
<210> 4006
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4006
cccaccaaac ccugaaccuu c 21
<210> 4007
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4007
cccacucuca gccagcuggg c 21
<210> 4008
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4008
cccagaacca gcccuguuug u 21
<210> 4009
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4009
cccagagaag auaauggcau u 21
<210> 4010
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4010
cccagccuaa accuccaaca c 21
<210> 4011
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4011
cccagccucu gguccuggag a 21
<210> 4012
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4012
cccagcuggc ugagaguggg a 21
<210> 4013
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4013
cccaggcuuu caaaggccag g 21
<210> 4014
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4014
cccaguccua auaaauacaa u 21
<210> 4015
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4015
cccauaaaca cccaaacucu c 21
<210> 4016
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4016
cccauguggu ugagacggug g 21
<210> 4017
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4017
ccccaaaccc agccuaaacc u 21
<210> 4018
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4018
ccccaaaccc uaaaccucua c 21
<210> 4019
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4019
ccccaaaugu cugcuuccac c 21
<210> 4020
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4020
ccccaaccgc accaucaaug a 21
<210> 4021
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4021
ccccaacuau acaugaaccc g 21
<210> 4022
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4022
ccccaagcug caaacuccca a 21
<210> 4023
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4023
ccccagaacc agcccuguuu g 21
<210> 4024
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4024
ccccagccuc ugguccugga g 21
<210> 4025
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4025
ccccaguccu aauaaauaca a 21
<210> 4026
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4026
cccccaaaug ucugcuucca c 21
<210> 4027
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4027
cccccaaccg caccaucaau g 21
<210> 4028
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4028
cccccucguu gcccaggcuu u 21
<210> 4029
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4029
ccccucguug cccaggcuuu c 21
<210> 4030
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4030
ccccugaauc cacaaacacc c 21
<210> 4031
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4031
cccgaaguag ccaaucuuua a 21
<210> 4032
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4032
cccggacacc cucaacucua c 21
<210> 4033
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4033
cccuaaacca acagaugacc u 21
<210> 4034
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4034
cccuaaaccu cuaccucucu a 21
<210> 4035
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4035
cccucaacuc uaccuaccca a 21
<210> 4036
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4036
cccucguugc ccaggcuuuc a 21
<210> 4037
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4037
cccugaaccu uccaaccagc g 21
<210> 4038
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4038
cccugaaucc acaaacaccc a 21
<210> 4039
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4039
cccugaauuc uacagggacc u 21
<210> 4040
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4040
cccuguagaa uucagggugc a 21
<210> 4041
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4041
cccuguuugu ggguagaguc a 21
<210> 4042
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4042
ccgaaguagc caaucuuuaa a 21
<210> 4043
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4043
ccgcaccauc aaugaacacc a 21
<210> 4044
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4044
ccggacaccc ucaacucuac c 21
<210> 4045
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4045
ccggcaguca cuggauccuc u 21
<210> 4046
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4046
ccggcgcacu ugccaaugcc a 21
<210> 4047
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4047
ccgggaguuu gaguguuuac a 21
<210> 4048
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4048
ccgucucaac cacaugggca g 21
<210> 4049
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4049
ccguggaaug acaagcccac u 21
<210> 4050
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4050
ccuaaaccaa cagaugaccu c 21
<210> 4051
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4051
ccuaaaccca cacaugcccc a 21
<210> 4052
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4052
ccuaaaccuc caacacccca g 21
<210> 4053
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4053
ccuaaaccuc uaccucucua a 21
<210> 4054
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4054
ccuacccaaa cccacauacg c 21
<210> 4055
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4055
ccucaaaucu uagagcaccc c 21
<210> 4056
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4056
ccucaacucu accuacccaa a 21
<210> 4057
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4057
ccucaauucu agaaacaucc c 21
<210> 4058
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4058
ccucacugga gucagcgccu g 21
<210> 4059
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4059
ccuccaacac cccaguccua a 21
<210> 4060
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4060
ccuccaaguc ucuggacuuc c 21
<210> 4061
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4061
ccucguugcc caggcuuuca a 21
<210> 4062
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4062
ccucuaaacc ucaaaucuua g 21
<210> 4063
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4063
ccucuaccuc ucuaaacacu c 21
<210> 4064
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4064
ccucuccagg accagaggcu g 21
<210> 4065
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4065
ccucucuaaa cacuccaaau a 21
<210> 4066
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4066
ccucuggucc uggagaggau c 21
<210> 4067
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4067
ccugaaccuu ccaaccagcg u 21
<210> 4068
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4068
ccugaaucca caaacaccca a 21
<210> 4069
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4069
ccugaauucu acagggaccu g 21
<210> 4070
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4070
ccugagaguu uggguguuua u 21
<210> 4071
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4071
ccugccaggc gcugacucca g 21
<210> 4072
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4072
ccugcccaug ugguugagac g 21
<210> 4073
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4073
ccugcuaacc ccugaaucca c 21
<210> 4074
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4074
ccuggacccc caaaugucug c 21
<210> 4075
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4075
ccuggagagg auccagugac u 21
<210> 4076
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4076
ccuggauucc acaaacaccc a 21
<210> 4077
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4077
ccuggcaggc ugugugcccc a 21
<210> 4078
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4078
ccuggccuuu gaaagccugg g 21
<210> 4079
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4079
ccugggcaac gagggggcca c 21
<210> 4080
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4080
ccuguagaau ucagggugca u 21
<210> 4081
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4081
ccuguuugug gguagaguca u 21
<210> 4082
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4082
ccuuccaacc agcgucagca a 21
<210> 4083
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4083
ccuuugaaag ccugggcaac g 21
<210> 4084
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4084
cgaaguagcc aaucuuuaaa c 21
<210> 4085
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4085
cgagggggcc acacauccca c 21
<210> 4086
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4086
cgauaccugg auuccacaaa c 21
<210> 4087
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4087
cgauuguggg ucuggaaguc c 21
<210> 4088
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4088
cgcaccauca augaacacca c 21
<210> 4089
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4089
cgcacuugcc aaugccauua u 21
<210> 4090
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4090
cgccaaaacc ucuaaaccuc a 21
<210> 4091
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4091
cgccaguccu cacuggaguc a 21
<210> 4092
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4092
cgccggcagu cacuggaucc u 21
<210> 4093
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4093
cgccuaaacc cacacaugcc c 21
<210> 4094
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4094
cgccuggcag gcugugugcc c 21
<210> 4095
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4095
cgcugacucc agugaggacu g 21
<210> 4096
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4096
cgcugguugg aagguucagg g 21
<210> 4097
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4097
cggacacccu caacucuacc u 21
<210> 4098
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4098
cggagguuug gacuuuacaa g 21
<210> 4099
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4099
cggagugggg cacgggagug g 21
<210> 4100
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4100
cggaugugag acgccagucc u 21
<210> 4101
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4101
cggcagucac uggauccucu c 21
<210> 4102
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4102
cggcgcacuu gccaaugcca u 21
<210> 4103
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4103
cgggaguggg cuugucauuc c 21
<210> 4104
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4104
cgggaguuug aguguuuaca u 21
<210> 4105
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4105
cggguucaug uauaguuggg g 21
<210> 4106
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4106
cgguggcagu gcccagagaa g 21
<210> 4107
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4107
cguauguggg uuuggguagg u 21
<210> 4108
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4108
cgucagcaac uccuccaagu c 21
<210> 4109
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4109
cgucucaacc acaugggcag g 21
<210> 4110
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4110
cgucucacau ccguggaaug a 21
<210> 4111
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4111
cguggaauga caagcccacu c 21
<210> 4112
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4112
cguggaauug gaguuuauau a 21
<210> 4113
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4113
cguugcccag gcuuucaaag g 21
<210> 4114
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4114
cuaaacacuc caaauaugua a 21
<210> 4115
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4115
cuaaaccaac agaugaccuc a 21
<210> 4116
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4116
cuaaacccac acaugcccca a 21
<210> 4117
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4117
cuaaaccuca aaucuuagag c 21
<210> 4118
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4118
cuaaaccucc aacaccccag u 21
<210> 4119
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4119
cuaaaccucu accucucuaa a 21
<210> 4120
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4120
cuaaccccug aauccacaaa c 21
<210> 4121
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4121
cuaagauuug agguuuagag g 21
<210> 4122
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4122
cuacagggac cuggaccccc a 21
<210> 4123
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4123
cuacccaaac ccacauacgc c 21
<210> 4124
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4124
cuacccacaa acagggcugg u 21
<210> 4125
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4125
cuaccuaccc aaacccacau a 21
<210> 4126
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4126
cuaccucucu aaacacucca a 21
<210> 4127
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4127
cuacuucggg uucauguaua g 21
<210> 4128
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4128
cuagaaacau cccaaacucc a 21
<210> 4129
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4129
cuagaauuga ggucaucugu u 21
<210> 4130
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4130
cuauacauga acccgaagua g 21
<210> 4131
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4131
cucaaacucc cggacacccu c 21
<210> 4132
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4132
cucaaaucuu agagcacccc a 21
<210> 4133
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4133
cucaaccaca ugggcaggac a 21
<210> 4134
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4134
cucaacucua ccuacccaaa c 21
<210> 4135
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4135
cucaauucua gaaacauccc a 21
<210> 4136
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4136
cucacaggca gcccaaauau a 21
<210> 4137
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4137
cucacaggca gcccaaaugu a 21
<210> 4138
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4138
cucacauccg uggaaugaca a 21
<210> 4139
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4139
cucacuggag ucagcgccug g 21
<210> 4140
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4140
cucagccagc ugggccuggc c 21
<210> 4141
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4141
cucaggcagc ccaaauguau a 21
<210> 4142
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4142
cuccaaauau guaaacacuc a 21
<210> 4143
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4143
cuccaacacc ccaguccuaa u 21
<210> 4144
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4144
cuccaagucu cuggacuucc a 21
<210> 4145
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4145
cuccaauucc accauaccug g 21
<210> 4146
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4146
cuccaauucc acgauaccug g 21
<210> 4147
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4147
cuccaauucc augauaccug g 21
<210> 4148
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4148
cuccaggacc agaggcuggg g 21
<210> 4149
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4149
cuccagugag gacuggcguc u 21
<210> 4150
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4150
cucccaaauc uuguaaaguc c 21
<210> 4151
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4151
cucccacucu cagccagcug g 21
<210> 4152
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4152
cucccggaca cccucaacuc u 21
<210> 4153
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4153
cuccuccaag ucucuggacu u 21
<210> 4154
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4154
cucggagguu uggacuuuac a 21
<210> 4155
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4155
cucguugccc aggcuuucaa a 21
<210> 4156
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4156
cucuaaacac uccaaauaug u 21
<210> 4157
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4157
cucuaaaccu caaaucuuag a 21
<210> 4158
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4158
cucuaagauu ugagguuuag a 21
<210> 4159
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4159
cucuacccac aaacagggcu g 21
<210> 4160
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4160
cucuaccuac ccaaacccac a 21
<210> 4161
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4161
cucuaccucu cuaaacacuc c 21
<210> 4162
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4162
cucucagcca gcugggccug g 21
<210> 4163
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4163
cucucaggca gcccaaaugu a 21
<210> 4164
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4164
cucuccagga ccagaggcug g 21
<210> 4165
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4165
cucucuaaac acuccaaaua u 21
<210> 4166
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4166
cucuggacuu ccagacccac a 21
<210> 4167
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4167
cucugggcac ugccaccguc u 21
<210> 4168
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4168
cucugguccu ggagaggauc c 21
<210> 4169
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4169
cugaaaauug caagucccca a 21
<210> 4170
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4170
cugaaccuuc caaccagcgu c 21
<210> 4171
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4171
cugaauccac aaacacccaa a 21
<210> 4172
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4172
cugaauucua cagggaccug g 21
<210> 4173
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4173
cugacgcugg uuggaagguu c 21
<210> 4174
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4174
cugacuccag ugaggacugg c 21
<210> 4175
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4175
cugagagugg gagucauggu g 21
<210> 4176
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4176
cugagaguuu ggguguuuau g 21
<210> 4177
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4177
cugcaaacuc ccaaaucuug u 21
<210> 4178
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4178
cugccaccgu cucaaccaca u 21
<210> 4179
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4179
cugccaggcg cugacuccag u 21
<210> 4180
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4180
cugcccaugu gguugagacg g 21
<210> 4181
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4181
cugccggcgc acuugccaau g 21
<210> 4182
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4182
cugccugaga guuugggugu u 21
<210> 4183
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4183
cugcuaaccc cugaauccac a 21
<210> 4184
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4184
cugcuguccu gcccaugugg u 21
<210> 4185
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4185
cugcuuccac cccagaacca g 21
<210> 4186
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4186
cuggaagucc agagacuugg a 21
<210> 4187
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4187
cuggaccccc aaaugucugc u 21
<210> 4188
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4188
cuggacuucc agacccacaa u 21
<210> 4189
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4189
cuggagagga uccagugacu g 21
<210> 4190
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4190
cuggagucag cgccuggcag g 21
<210> 4191
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4191
cuggauccuc uccaggacca g 21
<210> 4192
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4192
cuggauucca caaacaccca a 21
<210> 4193
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4193
cuggcaggcu gugugcccca g 21
<210> 4194
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4194
cuggccuuug aaagccuggg c 21
<210> 4195
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4195
cuggcgucuc acauccgugg a 21
<210> 4196
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4196
cuggcugaga gugggaguca u 21
<210> 4197
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4197
cugggcaacg agggggccac a 21
<210> 4198
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4198
cugggcacug ccaccgucuc a 21
<210> 4199
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4199
cugggccugg ccuuugaaag c 21
<210> 4200
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4200
cuggggcaca cagccugcca g 21
<210> 4201
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4201
cuggggugga agcagacauu u 21
<210> 4202
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4202
cugggguguu ggagguuuag g 21
<210> 4203
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4203
cuggguuugg ggugcucuaa g 21
<210> 4204
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4204
cugguccugg agaggaucca g 21
<210> 4205
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4205
cugguucugg gguggaagca g 21
<210> 4206
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4206
cugguuggaa gguucagggu u 21
<210> 4207
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4207
cuguagaauu cagggugcau u 21
<210> 4208
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4208
cuguccugcc caugugguug a 21
<210> 4209
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4209
cugucggagu ggggcacggg a 21
<210> 4210
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4210
cugugugccc cagccucugg u 21
<210> 4211
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4211
cuguugguuu aggguguaug u 21
<210> 4212
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4212
cuguuugugg guagagucau a 21
<210> 4213
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4213
cuuagagcac cccaaaccca g 21
<210> 4214
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4214
cuuccaacca gcgucagcaa c 21
<210> 4215
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4215
cuuccacccc agaaccagcc c 21
<210> 4216
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4216
cuuccagacc cacaaucgcc u 21
<210> 4217
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4217
cuucggguuc auguauaguu g 21
<210> 4218
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4218
cuucucuggg cacugccacc g 21
<210> 4219
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4219
cuugcaauuu ucaguguggg u 21
<210> 4220
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4220
cuugccaaug ccauuaucuu c 21
<210> 4221
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4221
cuuggaggag uugcugacgc u 21
<210> 4222
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4222
cuuggggacu ugcaauuuuc a 21
<210> 4223
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4223
cuuguaaagu ccaaaccucc g 21
<210> 4224
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4224
cuugucauuc cacggaugug a 21
<210> 4225
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4225
cuuuaaaccc acacugaaaa u 21
<210> 4226
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4226
cuuuacaaga uuugggaguu u 21
<210> 4227
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4227
cuuucaaagg ccaggcccag c 21
<210> 4228
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4228
cuuugaaagc cugggcaacg a 21
<210> 4229
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4229
gaaaauugca aguccccaag c 21
<210> 4230
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4230
gaaacauccc aaacuccaau u 21
<210> 4231
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4231
gaaagccugg gcaacgaggg g 21
<210> 4232
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4232
gaacaccaca uacacccuaa a 21
<210> 4233
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4233
gaaccagccc uguuuguggg u 21
<210> 4234
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4234
gaacccgaag uagccaaucu u 21
<210> 4235
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4235
gaaccuucca accagcguca g 21
<210> 4236
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4236
gaagauaaug gcauuggcaa g 21
<210> 4237
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4237
gaagcagaca uuuggggguc c 21
<210> 4238
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4238
gaagguucag gguuuggugg g 21
<210> 4239
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4239
gaaguagcca aucuuuaaac c 21
<210> 4240
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4240
gaaguccaga gacuuggagg a 21
<210> 4241
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4241
gaauccacaa acacccaaau g 21
<210> 4242
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4242
gaauccaggu aucauggaau u 21
<210> 4243
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4243
gaauccaggu aucguggaau u 21
<210> 4244
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4244
gaauccaggu augguggaau u 21
<210> 4245
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4245
gaaugacaag cccacucccg u 21
<210> 4246
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4246
gaaugauuau auauauuugg g 21
<210> 4247
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4247
gaauucaggg ugcauuuggg u 21
<210> 4248
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4248
gaauucuaca gggaccugga c 21
<210> 4249
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4249
gaauugaggu caucuguugg u 21
<210> 4250
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4250
gaauugauug uauuuauuag g 21
<210> 4251
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4251
gaauuggagu uugggauguu u 21
<210> 4252
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4252
gacaagccca cucccgugcc c 21
<210> 4253
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4253
gacacccuca acucuaccua c 21
<210> 4254
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4254
gacagcagcc accaugacuc c 21
<210> 4255
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4255
gacauuuggg gguccagguc c 21
<210> 4256
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4256
gaccagaggc uggggcacac a 21
<210> 4257
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4257
gacccacaau cgccuaaacc c 21
<210> 4258
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4258
gacccccaaa ugucugcuuc c 21
<210> 4259
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4259
gaccucaauu cuagaaacau c 21
<210> 4260
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4260
gaccuggacc cccaaauguc u 21
<210> 4261
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4261
gacgccaguc cucacuggag u 21
<210> 4262
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4262
gacgcugguu ggaagguuca g 21
<210> 4263
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4263
gacgguggca gugcccagag a 21
<210> 4264
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4264
gacuccagug aggacuggcg u 21
<210> 4265
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4265
gacucccacu cucagccagc u 21
<210> 4266
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4266
gacucggagg uuuggacuuu a 21
<210> 4267
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4267
gacucuaccc acaaacaggg c 21
<210> 4268
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4268
gacugccggc gcacuugcca a 21
<210> 4269
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4269
gacuggcguc ucacauccgu g 21
<210> 4270
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4270
gacuggggug uuggagguuu a 21
<210> 4271
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4271
gacuuccaga cccacaaucg c 21
<210> 4272
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4272
gacuugcaau uuucagugug g 21
<210> 4273
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4273
gacuuggagg aguugcugac g 21
<210> 4274
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4274
gacuuuacaa gauuugggag u 21
<210> 4275
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4275
gagaagauaa uggcauuggc a 21
<210> 4276
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4276
gagacgccag uccucacugg a 21
<210> 4277
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4277
gagacggugg cagugcccag a 21
<210> 4278
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4278
gagacucgga gguuuggacu u 21
<210> 4279
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4279
gagacuugga ggaguugcug a 21
<210> 4280
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4280
gagaggaucc agugacugcc g 21
<210> 4281
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4281
gagagguaga gguuuagggu u 21
<210> 4282
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4282
gagaguggga gucauggugg c 21
<210> 4283
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4283
gagaguuugg guguuuaugg g 21
<210> 4284
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4284
gagcacccca aacccagccu a 21
<210> 4285
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4285
gaggacuggc gucucacauc c 21
<210> 4286
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4286
gaggaguugc ugacgcuggu u 21
<210> 4287
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4287
gaggauccag ugacugccgg c 21
<210> 4288
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4288
gaggcugggg cacacagccu g 21
<210> 4289
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4289
gagggggcca cacaucccac c 21
<210> 4290
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4290
gagggugucc gggaguuuga g 21
<210> 4291
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4291
gagguagagg uuuaggguuu g 21
<210> 4292
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4292
gaggucaucu guugguuuag g 21
<210> 4293
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4293
gagguuuaga gguuuuggcg u 21
<210> 4294
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4294
gagguuuagg cuggguuugg g 21
<210> 4295
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4295
gagguuuagg guuuggggca u 21
<210> 4296
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4296
gagguuugga cuuuacaaga u 21
<210> 4297
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4297
gagguuuugg cguauguggg u 21
<210> 4298
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4298
gagucagcgc cuggcaggcu g 21
<210> 4299
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4299
gagucauggu ggcugcuguc c 21
<210> 4300
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4300
gagugggagu caugguggcu g 21
<210> 4301
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4301
gagugggcuu gucauuccac g 21
<210> 4302
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4302
gaguggggca cgggaguggg c 21
<210> 4303
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4303
gagugguuau gacucuaccc a 21
<210> 4304
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4304
gaguguuuac auauuuggag u 21
<210> 4305
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4305
gaguguuuag agagguagag g 21
<210> 4306
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4306
gaguugaggg uguccgggag u 21
<210> 4307
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4307
gaguugcuga cgcugguugg a 21
<210> 4308
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4308
gaguuuauau acauuugggc u 21
<210> 4309
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4309
gaguuugagu guuuacauau u 21
<210> 4310
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4310
gaguuugcag cuuggggacu u 21
<210> 4311
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4311
gaguuuggga uguuucuaga a 21
<210> 4312
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4312
gaguuugggu guuuaugggu u 21
<210> 4313
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4313
gauaauggca uuggcaagug c 21
<210> 4314
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4314
gauccaguga cugccggcgc a 21
<210> 4315
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4315
gauccucucc aggaccagag g 21
<210> 4316
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4316
gaugaccuca auucuagaaa c 21
<210> 4317
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4317
gaugugagac gccaguccuc a 21
<210> 4318
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4318
gauguguggc ccccucguug c 21
<210> 4319
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4319
gauguuucua gaauugaggu c 21
<210> 4320
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4320
gauuauauau auuugggcug c 21
<210> 4321
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4321
gauucagggg uuagcagguu g 21
<210> 4322
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4322
gauuccacaa acacccaacc c 21
<210> 4323
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4323
gauuggcuac uucggguuca u 21
<210> 4324
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4324
gauuguauuu auuaggacug g 21
<210> 4325
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4325
gauugugggu cuggaagucc a 21
<210> 4326
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4326
gauuugaggu uuagagguuu u 21
<210> 4327
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4327
gauuugggag uuugcagcuu g 21
<210> 4328
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4328
gcaaacuccc aaaucuugua a 21
<210> 4329
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4329
gcaacgaggg ggccacacau c 21
<210> 4330
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4330
gcaacuccuc caagucucug g 21
<210> 4331
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4331
gcaagucccc aagcugcaaa c 21
<210> 4332
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4332
gcaagugcgc cggcagucac u 21
<210> 4333
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4333
gcaauuuuca guguggguuu a 21
<210> 4334
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4334
gcacacagcc ugccaggcgc u 21
<210> 4335
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4335
gcaccaucaa ugaacaccac a 21
<210> 4336
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4336
gcaccccaaa cccagccuaa a 21
<210> 4337
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4337
gcacccugaa uucuacaggg a 21
<210> 4338
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4338
gcacgggagu gggcuuguca u 21
<210> 4339
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4339
gcacugccac cgucucaacc a 21
<210> 4340
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4340
gcagacauuu ggggguccag g 21
<210> 4341
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4341
gcagccacca ugacucccac u 21
<210> 4342
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4342
gcagcccaaa uauauauaau c 21
<210> 4343
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4343
gcagcuuggg gacuugcaau u 21
<210> 4344
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4344
gcaggacagc agccaccaug a 21
<210> 4345
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4345
gcaggcugug ugccccagcc u 21
<210> 4346
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4346
gcagucacug gauccucucc a 21
<210> 4347
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4347
gcagugccca gagaagauaa u 21
<210> 4348
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4348
gcaugugugg guuuaggcga u 21
<210> 4349
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4349
gcauuggcaa gugcgccggc a 21
<210> 4350
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4350
gcauuugggu guuuguggau u 21
<210> 4351
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4351
gccaaaaccu cuaaaccuca a 21
<210> 4352
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4352
gccaaucuuu aaacccacac u 21
<210> 4353
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4353
gccaaugcca uuaucuucuc u 21
<210> 4354
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4354
gccacacauc ccaccaaacc c 21
<210> 4355
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4355
gccaccauga cucccacucu c 21
<210> 4356
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4356
gccaccgucu caaccacaug g 21
<210> 4357
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4357
gccagcuggg ccuggccuuu g 21
<210> 4358
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4358
gccaggccca gcuggcugag a 21
<210> 4359
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4359
gccaggcgcu gacuccagug a 21
<210> 4360
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4360
gccaguccuc acuggaguca g 21
<210> 4361
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4361
gccauuaucu ucucugggca c 21
<210> 4362
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4362
gcccaaauau auauaaucau u 21
<210> 4363
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4363
gcccacuccc gugccccacu c 21
<210> 4364
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4364
gcccagagaa gauaauggca u 21
<210> 4365
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4365
gcccagcugg cugagagugg g 21
<210> 4366
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4366
gcccaggcuu ucaaaggcca g 21
<210> 4367
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4367
gcccaugugg uugagacggu g 21
<210> 4368
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4368
gccccaaacc cuaaaccucu a 21
<210> 4369
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4369
gccccaacua uacaugaacc c 21
<210> 4370
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4370
gccccagccu cugguccugg a 21
<210> 4371
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4371
gcccccucgu ugcccaggcu u 21
<210> 4372
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4372
gcccuguuug uggguagagu c 21
<210> 4373
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4373
gccggcaguc acuggauccu c 21
<210> 4374
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4374
gccggcgcac uugccaaugc c 21
<210> 4375
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4375
gccuaaaccc acacaugccc c 21
<210> 4376
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4376
gccuaaaccu ccaacacccc a 21
<210> 4377
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4377
gccucugguc cuggagagga u 21
<210> 4378
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4378
gccugagagu uuggguguuu a 21
<210> 4379
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4379
gccugccagg cgcugacucc a 21
<210> 4380
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4380
gccuggcagg cugugugccc c 21
<210> 4381
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4381
gccuggccuu ugaaagccug g 21
<210> 4382
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4382
gccugggcaa cgagggggcc a 21
<210> 4383
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4383
gccuuugaaa gccugggcaa c 21
<210> 4384
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4384
gcgauugugg gucuggaagu c 21
<210> 4385
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4385
gcgcacuugc caaugccauu a 21
<210> 4386
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4386
gcgccggcag ucacuggauc c 21
<210> 4387
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4387
gcgccuggca ggcugugugc c 21
<210> 4388
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4388
gcgcugacuc cagugaggac u 21
<210> 4389
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4389
gcguaugugg guuuggguag g 21
<210> 4390
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4390
gcgucagcaa cuccuccaag u 21
<210> 4391
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4391
gcgucucaca uccguggaau g 21
<210> 4392
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4392
gcuaaccccu gaauccacaa a 21
<210> 4393
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4393
gcuacuucgg guucauguau a 21
<210> 4394
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4394
gcucuaagau uugagguuua g 21
<210> 4395
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4395
gcugacgcug guuggaaggu u 21
<210> 4396
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4396
gcugacucca gugaggacug g 21
<210> 4397
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4397
gcugagagug ggagucaugg u 21
<210> 4398
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4398
gcugcaaacu cccaaaucuu g 21
<210> 4399
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4399
gcugccugag aguuugggug u 21
<210> 4400
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4400
gcugcugucc ugcccaugug g 21
<210> 4401
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4401
gcuggcugag agugggaguc a 21
<210> 4402
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4402
gcugggccug gccuuugaaa g 21
<210> 4403
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4403
gcuggggcac acagccugcc a 21
<210> 4404
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4404
gcuggguuug gggugcucua a 21
<210> 4405
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4405
gcugguucug ggguggaagc a 21
<210> 4406
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4406
gcugguugga agguucaggg u 21
<210> 4407
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4407
gcuguccugc ccaugugguu g 21
<210> 4408
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4408
gcugugugcc ccagccucug g 21
<210> 4409
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4409
gcuuccaccc cagaaccagc c 21
<210> 4410
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4410
gcuuggggac uugcaauuuu c 21
<210> 4411
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4411
gcuugucauu ccacggaugu g 21
<210> 4412
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4412
gcuuucaaag gccaggccca g 21
<210> 4413
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4413
ggaagcagac auuugggggu c 21
<210> 4414
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4414
ggaagguuca ggguuuggug g 21
<210> 4415
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4415
ggaaguccag agacuuggag g 21
<210> 4416
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4416
ggaauccagg uaucauggaa u 21
<210> 4417
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4417
ggaauccagg uaucguggaa u 21
<210> 4418
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4418
ggaauccagg uaugguggaa u 21
<210> 4419
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4419
ggaaugacaa gcccacuccc g 21
<210> 4420
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4420
ggaaugauua uauauauuug g 21
<210> 4421
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4421
ggaauugauu guauuuauua g 21
<210> 4422
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4422
ggaauuggag uuugggaugu u 21
<210> 4423
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4423
ggacacccuc aacucuaccu a 21
<210> 4424
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4424
ggacagcagc caccaugacu c 21
<210> 4425
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4425
ggaccagagg cuggggcaca c 21
<210> 4426
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4426
ggacccccaa augucugcuu c 21
<210> 4427
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4427
ggaccuggac ccccaaaugu c 21
<210> 4428
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4428
ggacuggcgu cucacauccg u 21
<210> 4429
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4429
ggacuggggu guuggagguu u 21
<210> 4430
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4430
ggacuuccag acccacaauc g 21
<210> 4431
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4431
ggacuugcaa uuuucagugu g 21
<210> 4432
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4432
ggacuuuaca agauuuggga g 21
<210> 4433
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4433
ggagacucgg agguuuggac u 21
<210> 4434
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4434
ggagaggauc cagugacugc c 21
<210> 4435
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4435
ggaggaguug cugacgcugg u 21
<210> 4436
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4436
ggagguuuag gcuggguuug g 21
<210> 4437
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4437
ggagguuugg acuuuacaag a 21
<210> 4438
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4438
ggagucagcg ccuggcaggc u 21
<210> 4439
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4439
ggagucaugg uggcugcugu c 21
<210> 4440
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4440
ggagugggcu ugucauucca c 21
<210> 4441
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4441
ggaguggggc acgggagugg g 21
<210> 4442
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4442
ggaguguuua gagagguaga g 21
<210> 4443
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4443
ggaguugcug acgcugguug g 21
<210> 4444
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4444
ggaguuugag uguuuacaua u 21
<210> 4445
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4445
ggaguuugca gcuuggggac u 21
<210> 4446
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4446
ggaguuuggg auguuucuag a 21
<210> 4447
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4447
ggauccagug acugccggcg c 21
<210> 4448
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4448
ggauccucuc caggaccaga g 21
<210> 4449
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4449
ggaugugaga cgccaguccu c 21
<210> 4450
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4450
ggaugugugg cccccucguu g 21
<210> 4451
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4451
ggauguuucu agaauugagg u 21
<210> 4452
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4452
ggauucaggg guuagcaggu u 21
<210> 4453
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4453
ggauuccaca aacacccaac c 21
<210> 4454
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4454
ggcaacgagg gggccacaca u 21
<210> 4455
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4455
ggcaagugcg ccggcaguca c 21
<210> 4456
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4456
ggcacacagc cugccaggcg c 21
<210> 4457
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4457
ggcacgggag ugggcuuguc a 21
<210> 4458
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4458
ggcacugcca ccgucucaac c 21
<210> 4459
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4459
ggcagcccaa auauauauaa u 21
<210> 4460
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4460
ggcaggacag cagccaccau g 21
<210> 4461
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4461
ggcaggcugu gugccccagc c 21
<210> 4462
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4462
ggcagucacu ggauccucuc c 21
<210> 4463
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4463
ggcagugccc agagaagaua a 21
<210> 4464
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4464
ggcaugugug gguuuaggcg a 21
<210> 4465
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4465
ggcauuggca agugcgccgg c 21
<210> 4466
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4466
ggccacacau cccaccaaac c 21
<210> 4467
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4467
ggccaggccc agcuggcuga g 21
<210> 4468
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4468
ggcccagcug gcugagagug g 21
<210> 4469
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4469
ggcccccucg uugcccaggc u 21
<210> 4470
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4470
ggccuggccu uugaaagccu g 21
<210> 4471
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4471
ggccuuugaa agccugggca a 21
<210> 4472
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4472
ggcgauugug ggucuggaag u 21
<210> 4473
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4473
ggcgcacuug ccaaugccau u 21
<210> 4474
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4474
ggcgcugacu ccagugagga c 21
<210> 4475
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4475
ggcguaugug gguuugggua g 21
<210> 4476
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4476
ggcgucucac auccguggaa u 21
<210> 4477
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4477
ggcuacuucg gguucaugua u 21
<210> 4478
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4478
ggcugagagu gggagucaug g 21
<210> 4479
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4479
ggcugccuga gaguuugggu g 21
<210> 4480
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4480
ggcugcuguc cugcccaugu g 21
<210> 4481
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4481
ggcuggggca cacagccugc c 21
<210> 4482
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4482
ggcuggguuu ggggugcucu a 21
<210> 4483
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4483
ggcugguucu gggguggaag c 21
<210> 4484
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4484
ggcugugugc cccagccucu g 21
<210> 4485
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4485
ggcuugucau uccacggaug u 21
<210> 4486
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4486
ggcuuucaaa ggccaggccc a 21
<210> 4487
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4487
gggaaugauu auauauauuu g 21
<210> 4488
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4488
gggaccugga cccccaaaug u 21
<210> 4489
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4489
gggacuugca auuuucagug u 21
<210> 4490
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4490
gggagucaug guggcugcug u 21
<210> 4491
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4491
gggagugggc uugucauucc a 21
<210> 4492
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4492
gggaguuuga guguuuacau a 21
<210> 4493
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4493
gggaguuugc agcuugggga c 21
<210> 4494
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4494
gggaugugug gcccccucgu u 21
<210> 4495
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4495
gggauguuuc uagaauugag g 21
<210> 4496
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4496
gggcaacgag ggggccacac a 21
<210> 4497
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4497
gggcacacag ccugccaggc g 21
<210> 4498
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4498
gggcacggga gugggcuugu c 21
<210> 4499
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4499
gggcacugcc accgucucaa c 21
<210> 4500
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4500
gggcaggaca gcagccacca u 21
<210> 4501
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4501
gggcaugugu ggguuuaggc g 21
<210> 4502
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4502
gggccacaca ucccaccaaa c 21
<210> 4503
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4503
gggccuggcc uuugaaagcc u 21
<210> 4504
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4504
gggcugccug agaguuuggg u 21
<210> 4505
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4505
gggcugguuc ugggguggaa g 21
<210> 4506
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4506
gggcuuguca uuccacggau g 21
<210> 4507
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4507
ggggacuugc aauuuucagu g 21
<210> 4508
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4508
ggggcacaca gccugccagg c 21
<210> 4509
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4509
ggggcacggg agugggcuug u 21
<210> 4510
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4510
ggggcaugug uggguuuagg c 21
<210> 4511
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4511
ggggcauuug gaauugauug u 21
<210> 4512
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4512
ggggccacac aucccaccaa a 21
<210> 4513
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4513
gggggccaca caucccacca a 21
<210> 4514
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4514
ggggguccag gucccuguag a 21
<210> 4515
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4515
gggguccagg ucccuguaga a 21
<210> 4516
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4516
ggggugcucu aagauuugag g 21
<210> 4517
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4517
gggguggaag cagacauuug g 21
<210> 4518
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4518
gggguguugg agguuuaggc u 21
<210> 4519
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4519
gggguuagca gguugggaau g 21
<210> 4520
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4520
ggguagguag aguugagggu g 21
<210> 4521
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4521
ggguccaggu cccuguagaa u 21
<210> 4522
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4522
gggucuggaa guccagagac u 21
<210> 4523
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4523
gggugcauuu ggguguuugu g 21
<210> 4524
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4524
gggugcucua agauuugagg u 21
<210> 4525
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4525
ggguggaagc agacauuugg g 21
<210> 4526
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4526
ggguguaugu gguguucauu g 21
<210> 4527
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4527
ggguguccgg gaguuugagu g 21
<210> 4528
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4528
ggguguugga gguuuaggcu g 21
<210> 4529
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4529
ggguguuuau ggguugggug u 21
<210> 4530
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4530
ggguguuugu ggaauccagg u 21
<210> 4531
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4531
ggguguuugu ggauucaggg g 21
<210> 4532
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4532
ggguuagcag guugggaaug a 21
<210> 4533
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4533
ggguucaugu auaguugggg c 21
<210> 4534
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4534
ggguugggug uuuguggaau c 21
<210> 4535
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4535
ggguuuaaag auuggcuacu u 21
<210> 4536
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4536
ggguuuaggc gauugugggu c 21
<210> 4537
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4537
ggguuugggg cauguguggg u 21
<210> 4538
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4538
ggguuugggg ugcucuaaga u 21
<210> 4539
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4539
ggguuugggu agguagaguu g 21
<210> 4540
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4540
ggguuuggug ggaugugugg c 21
<210> 4541
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4541
gguagagguu uaggguuugg g 21
<210> 4542
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4542
gguagaguug aggguguccg g 21
<210> 4543
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4543
gguagguaga guugagggug u 21
<210> 4544
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4544
gguaucaugg aauuggaguu u 21
<210> 4545
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4545
gguaucgugg aauuggaguu u 21
<210> 4546
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4546
gguauggugg aauuggaguu u 21
<210> 4547
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4547
ggucaucugu ugguuuaggg u 21
<210> 4548
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4548
gguccagguc ccuguagaau u 21
<210> 4549
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4549
ggucccugua gaauucaggg u 21
<210> 4550
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4550
gguccuggag aggauccagu g 21
<210> 4551
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4551
ggucuggaag uccagagacu u 21
<210> 4552
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4552
ggugcauuug gguguuugug g 21
<210> 4553
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4553
ggugcucuaa gauuugaggu u 21
<210> 4554
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4554
gguggaagca gacauuuggg g 21
<210> 4555
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4555
gguggaauug gaguuuggga u 21
<210> 4556
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4556
gguggcagug cccagagaag a 21
<210> 4557
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4557
gguggcugcu guccugccca u 21
<210> 4558
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4558
ggugggaugu guggcccccu c 21
<210> 4559
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4559
gguguaugug guguucauug a 21
<210> 4560
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4560
gguguccggg aguuugagug u 21
<210> 4561
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4561
gguguuggag guuuaggcug g 21
<210> 4562
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4562
gguguuuaug gguugggugu u 21
<210> 4563
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4563
gguguuugug gaauccaggu a 21
<210> 4564
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4564
gguguuugug gauucagggg u 21
<210> 4565
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4565
gguuagcagg uugggaauga u 21
<210> 4566
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4566
gguuaugacu cuacccacaa a 21
<210> 4567
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4567
gguucagggu uuggugggau g 21
<210> 4568
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4568
gguucaugua uaguuggggc a 21
<210> 4569
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4569
gguucugggg uggaagcaga c 21
<210> 4570
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4570
gguugagacg guggcagugc c 21
<210> 4571
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4571
gguuggaagg uucaggguuu g 21
<210> 4572
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4572
gguugggaau gauuauauau a 21
<210> 4573
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4573
gguuuaaaga uuggcuacuu c 21
<210> 4574
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4574
gguuuagagg uuuuggcgua u 21
<210> 4575
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4575
gguuuaggcg auuguggguc u 21
<210> 4576
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4576
gguuuaggcu ggguuugggg u 21
<210> 4577
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4577
gguuuagggu guauguggug u 21
<210> 4578
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4578
gguuuagggu uuggggcaug u 21
<210> 4579
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4579
gguuuggacu uuacaagauu u 21
<210> 4580
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4580
gguuuggggc augugugggu u 21
<210> 4581
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4581
gguuuggggu gcucuaagau u 21
<210> 4582
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4582
gguuugggua gguagaguug a 21
<210> 4583
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4583
gguuuggugg gauguguggc c 21
<210> 4584
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4584
gguuuuggcg uauguggguu u 21
<210> 4585
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4585
guaaacacuc aaacucccgg a 21
<210> 4586
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4586
guaaagucca aaccuccgag u 21
<210> 4587
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4587
guagaauuca gggugcauuu g 21
<210> 4588
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4588
guagagguuu aggguuuggg g 21
<210> 4589
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4589
guagaguuga ggguguccgg g 21
<210> 4590
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4590
guagccaauc uuuaaaccca c 21
<210> 4591
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4591
guagguagag uugagggugu c 21
<210> 4592
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4592
guauaguugg ggcauuugga a 21
<210> 4593
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4593
guauauaaac uccaauucca c 21
<210> 4594
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4594
guauauaaac uccaauucca u 21
<210> 4595
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4595
guaucgugga auuggaguuu a 21
<210> 4596
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4596
guauggugga auuggaguuu g 21
<210> 4597
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4597
guaugugggu uuggguaggu a 21
<210> 4598
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4598
guauguggug uucauugaug g 21
<210> 4599
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4599
guauuuauua ggacuggggu g 21
<210> 4600
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4600
gucacuggau ccucuccagg a 21
<210> 4601
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4601
gucagcaacu ccuccaaguc u 21
<210> 4602
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4602
gucagcgccu ggcaggcugu g 21
<210> 4603
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4603
gucaucuguu gguuuagggu g 21
<210> 4604
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4604
gucauggugg cugcuguccu g 21
<210> 4605
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4605
gucauuccac ggaugugaga c 21
<210> 4606
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4606
guccagagac uuggaggagu u 21
<210> 4607
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4607
guccaggucc cuguagaauu c 21
<210> 4608
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4608
guccccaagc ugcaaacucc c 21
<210> 4609
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4609
gucccuguag aauucagggu g 21
<210> 4610
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4610
guccgggagu uugaguguuu a 21
<210> 4611
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4611
guccucacug gagucagcgc c 21
<210> 4612
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4612
guccugccca ugugguugag a 21
<210> 4613
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4613
guccuggaga ggauccagug a 21
<210> 4614
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4614
gucggagugg ggcacgggag u 21
<210> 4615
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4615
gucucaacca caugggcagg a 21
<210> 4616
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4616
gucucacauc cguggaauga c 21
<210> 4617
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4617
gucucuggac uuccagaccc a 21
<210> 4618
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4618
gucugcuucc accccagaac c 21
<210> 4619
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4619
gucuggaagu ccagagacuu g 21
<210> 4620
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4620
gugacugccg gcgcacuugc c 21
<210> 4621
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4621
gugagacgcc aguccucacu g 21
<210> 4622
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4622
gugaggacug gcgucucaca u 21
<210> 4623
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4623
gugagugguu augacucuac c 21
<210> 4624
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4624
gugcauuugg guguuugugg a 21
<210> 4625
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4625
gugcccagag aagauaaugg c 21
<210> 4626
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4626
gugccccagc cucugguccu g 21
<210> 4627
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4627
gugcgccggc agucacugga u 21
<210> 4628
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4628
gugcucuaag auuugagguu u 21
<210> 4629
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4629
guggaagcag acauuugggg g 21
<210> 4630
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4630
guggaaucca gguaucaugg a 21
<210> 4631
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4631
guggaaucca gguaucgugg a 21
<210> 4632
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4632
guggaaucca gguauggugg a 21
<210> 4633
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4633
guggaaugac aagcccacuc c 21
<210> 4634
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4634
guggaauugg aguuuauaua c 21
<210> 4635
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4635
guggaauugg aguuugggau g 21
<210> 4636
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4636
guggauucag ggguuagcag g 21
<210> 4637
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4637
guggcagugc ccagagaaga u 21
<210> 4638
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4638
guggcccccu cguugcccag g 21
<210> 4639
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4639
guggcugcug uccugcccau g 21
<210> 4640
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4640
gugggaguca ugguggcugc u 21
<210> 4641
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4641
gugggaugug uggcccccuc g 21
<210> 4642
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4642
gugggcuugu cauuccacgg a 21
<210> 4643
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4643
guggggcacg ggagugggcu u 21
<210> 4644
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4644
gugggucugg aaguccagag a 21
<210> 4645
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4645
guggguuuaa agauuggcua c 21
<210> 4646
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4646
guggguuuag gcgauugugg g 21
<210> 4647
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4647
guggguuugg guagguagag u 21
<210> 4648
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4648
gugguguuca uugauggugc g 21
<210> 4649
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4649
gugguuauga cucuacccac a 21
<210> 4650
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4650
gugguugaga cgguggcagu g 21
<210> 4651
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4651
guguaugugg uguucauuga u 21
<210> 4652
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4652
guguccggga guuugagugu u 21
<210> 4653
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4653
gugugcccca gccucugguc c 21
<210> 4654
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4654
guguggcccc cucguugccc a 21
<210> 4655
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4655
guguggguuu aaagauuggc u 21
<210> 4656
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4656
guguggguuu aggcgauugu g 21
<210> 4657
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4657
guguuggagg uuuaggcugg g 21
<210> 4658
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4658
guguuuacau auuuggagug u 21
<210> 4659
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4659
guguuuagag agguagaggu u 21
<210> 4660
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4660
guguuuaugg guuggguguu u 21
<210> 4661
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4661
guguuugugg aauccaggua u 21
<210> 4662
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4662
guguuugugg auucaggggu u 21
<210> 4663
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4663
guuagcaggu ugggaaugau u 21
<210> 4664
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4664
guuaugacuc uacccacaaa c 21
<210> 4665
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4665
guucaggguu uggugggaug u 21
<210> 4666
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4666
guucauguau aguuggggca u 21
<210> 4667
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4667
guucuggggu ggaagcagac a 21
<210> 4668
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4668
guugagacgg uggcagugcc c 21
<210> 4669
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4669
guugagggug uccgggaguu u 21
<210> 4670
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4670
guugcccagg cuuucaaagg c 21
<210> 4671
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4671
guugcugacg cugguuggaa g 21
<210> 4672
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4672
guuggaaggu ucaggguuug g 21
<210> 4673
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4673
guuggagguu uaggcugggu u 21
<210> 4674
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4674
guugggaaug auuauauaua u 21
<210> 4675
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4675
guuggggcau uuggaauuga u 21
<210> 4676
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4676
guuggguguu uguggaaucc a 21
<210> 4677
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4677
guugguuuag gguguaugug g 21
<210> 4678
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4678
guuuaaagau uggcuacuuc g 21
<210> 4679
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4679
guuuacauau uuggaguguu u 21
<210> 4680
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4680
guuuagagag guagagguuu a 21
<210> 4681
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4681
guuuagaggu uuuggcguau g 21
<210> 4682
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4682
guuuaggcga uugugggucu g 21
<210> 4683
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4683
guuuaggcug gguuuggggu g 21
<210> 4684
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4684
guuuagggug uauguggugu u 21
<210> 4685
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4685
guuuaggguu uggggcaugu g 21
<210> 4686
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4686
guuuauauac auuugggcug c 21
<210> 4687
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4687
guuuaugggu uggguguuug u 21
<210> 4688
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4688
guuucuagaa uugaggucau c 21
<210> 4689
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4689
guuugagugu uuacauauuu g 21
<210> 4690
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4690
guuugcagcu uggggacuug c 21
<210> 4691
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4691
guuuggacuu uacaagauuu g 21
<210> 4692
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4692
guuugggaug uuucuagaau u 21
<210> 4693
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4693
guuuggggca uguguggguu u 21
<210> 4694
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4694
guuuggggug cucuaagauu u 21
<210> 4695
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4695
guuuggguag guagaguuga g 21
<210> 4696
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4696
guuugggugu uuauggguug g 21
<210> 4697
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4697
guuugguggg auguguggcc c 21
<210> 4698
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4698
guuuguggaa uccagguauc a 21
<210> 4699
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4699
guuuguggaa uccagguauc g 21
<210> 4700
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4700
guuuguggaa uccagguaug g 21
<210> 4701
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4701
guuuguggau ucagggguua g 21
<210> 4702
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4702
guuugugggu agagucauaa c 21
<210> 4703
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4703
guuuuggcgu auguggguuu g 21
<210> 4704
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4704
uaaacaccca aacucucagg c 21
<210> 4705
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4705
uaaacacuca aacucccgga c 21
<210> 4706
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4706
uaaaccaaca gaugaccuca a 21
<210> 4707
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4707
uaaacccaca caugccccaa a 21
<210> 4708
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4708
uaaacccaca cugaaaauug c 21
<210> 4709
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4709
uaaaccucaa aucuuagagc a 21
<210> 4710
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4710
uaaaccucca acaccccagu c 21
<210> 4711
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4711
uaaaccucua ccucucuaaa c 21
<210> 4712
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4712
uaaacuccaa uuccacgaua c 21
<210> 4713
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4713
uaaacuccaa uuccaugaua c 21
<210> 4714
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4714
uaaagauugg cuacuucggg u 21
<210> 4715
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4715
uaaauacaau caauuccaaa u 21
<210> 4716
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4716
uaaccccuga auccacaaac a 21
<210> 4717
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4717
uaagauuuga gguuuagagg u 21
<210> 4718
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4718
uaaucauucc caaccugcua a 21
<210> 4719
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4719
uaauggcauu ggcaagugcg c 21
<210> 4720
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4720
uacaagauuu gggaguuugc a 21
<210> 4721
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4721
uacaaucaau uccaaaugcc c 21
<210> 4722
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4722
uacacccuaa accaacagau g 21
<210> 4723
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4723
uacagggacc uggaccccca a 21
<210> 4724
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4724
uacauauuug gaguguuuag a 21
<210> 4725
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4725
uacaugaacc cgaaguagcc a 21
<210> 4726
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4726
uacauuuggg cugccugaga g 21
<210> 4727
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4727
uacauuuggg cugccuguga g 21
<210> 4728
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4728
uacccaaacc cacauacgcc a 21
<210> 4729
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4729
uacccacaaa cagggcuggu u 21
<210> 4730
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4730
uaccuaccca aacccacaua c 21
<210> 4731
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4731
uaccucucua aacacuccaa a 21
<210> 4732
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4732
uaccuggauu ccacaaacac c 21
<210> 4733
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4733
uacgccaaaa ccucuaaacc u 21
<210> 4734
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4734
uacuucgggu ucauguauag u 21
<210> 4735
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4735
uagaaacauc ccaaacucca a 21
<210> 4736
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4736
uagaauucag ggugcauuug g 21
<210> 4737
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4737
uagaauugag gucaucuguu g 21
<210> 4738
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4738
uagagaggua gagguuuagg g 21
<210> 4739
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4739
uagagcaccc caaacccagc c 21
<210> 4740
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4740
uagagguuua ggguuugggg c 21
<210> 4741
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4741
uagagguuuu ggcguaugug g 21
<210> 4742
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4742
uagaguugag gguguccggg a 21
<210> 4743
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4743
uagccaaucu uuaaacccac a 21
<210> 4744
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4744
uaggacuggg guguuggagg u 21
<210> 4745
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4745
uaggcgauug ugggucugga a 21
<210> 4746
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4746
uaggcugggu uuggggugcu c 21
<210> 4747
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4747
uaggguguau gugguguuca u 21
<210> 4748
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4748
uaggguuugg ggcaugugug g 21
<210> 4749
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4749
uagguagagu ugaggguguc c 21
<210> 4750
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4750
uaguuggggc auuuggaauu g 21
<210> 4751
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4751
uauaaacucc aauuccacga u 21
<210> 4752
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4752
uauaaacucc aauuccauga u 21
<210> 4753
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4753
uauaaucauu cccaaccugc u 21
<210> 4754
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4754
uauacaugaa cccgaaguag c 21
<210> 4755
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4755
uauacauuug ggcugccuga g 21
<210> 4756
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4756
uauacauuug ggcugccugu g 21
<210> 4757
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4757
uauaguuggg gcauuuggaa u 21
<210> 4758
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4758
uauauaaacu ccaauuccac g 21
<210> 4759
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4759
uauauaauca uucccaaccu g 21
<210> 4760
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4760
uauauacauu ugggcugccu g 21
<210> 4761
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4761
uauauauauu ugggcugccu g 21
<210> 4762
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4762
uauauauuug ggcugccugu g 21
<210> 4763
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4763
uauauuuggg cugccuguga g 21
<210> 4764
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4764
uaucuucucu gggcacugcc a 21
<210> 4765
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4765
uaugacucua cccacaaaca g 21
<210> 4766
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4766
uauggguugg guguuugugg a 21
<210> 4767
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4767
uaugguggaa uuggaguuug g 21
<210> 4768
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4768
uauguaaaca cucaaacucc c 21
<210> 4769
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4769
uauguggguu uggguaggua g 21
<210> 4770
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4770
uauguggugu ucauugaugg u 21
<210> 4771
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4771
uauuaggacu gggguguugg a 21
<210> 4772
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4772
uauuuauuag gacuggggug u 21
<210> 4773
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4773
uauuuggagu guuuagagag g 21
<210> 4774
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4774
uauuugggcu gccugugagu u 21
<210> 4775
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4775
ucaaacuccc ggacacccuc a 21
<210> 4776
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4776
ucaaaggcca ggcccagcug g 21
<210> 4777
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4777
ucaaaucuua gagcacccca a 21
<210> 4778
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4778
ucaaccacau gggcaggaca g 21
<210> 4779
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4779
ucaacucuac cuacccaaac c 21
<210> 4780
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4780
ucaaugaaca ccacauacac c 21
<210> 4781
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4781
ucaauuccaa augccccaac u 21
<210> 4782
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4782
ucaauucuag aaacauccca a 21
<210> 4783
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4783
ucacaggcag cccaaauaua u 21
<210> 4784
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4784
ucacaggcag cccaaaugua u 21
<210> 4785
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4785
ucacauccgu ggaaugacaa g 21
<210> 4786
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4786
ucacuggagu cagcgccugg c 21
<210> 4787
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4787
ucacuggauc cucuccagga c 21
<210> 4788
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4788
ucagcaacuc cuccaagucu c 21
<210> 4789
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4789
ucagccagcu gggccuggcc u 21
<210> 4790
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4790
ucagcgccug gcaggcugug u 21
<210> 4791
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4791
ucaggcagcc caaauguaua u 21
<210> 4792
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4792
ucagggguua gcagguuggg a 21
<210> 4793
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4793
ucagggugca uuuggguguu u 21
<210> 4794
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4794
ucaggguuug gugggaugug u 21
<210> 4795
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4795
ucaguguggg uuuaaagauu g 21
<210> 4796
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4796
ucaucuguug guuuagggug u 21
<210> 4797
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4797
ucaugguggc ugcuguccug c 21
<210> 4798
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4798
ucauguauag uuggggcauu u 21
<210> 4799
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4799
ucauuccacg gaugugagac g 21
<210> 4800
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4800
ucauucccaa ccugcuaacc c 21
<210> 4801
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4801
uccaaauaug uaaacacuca a 21
<210> 4802
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4802
uccaaaugcc ccaacuauac a 21
<210> 4803
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4803
uccaacaccc caguccuaau a 21
<210> 4804
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4804
uccaaccagc gucagcaacu c 21
<210> 4805
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4805
uccaagucuc uggacuucca g 21
<210> 4806
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4806
uccaauucca ccauaccugg a 21
<210> 4807
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4807
uccaauucca cgauaccugg a 21
<210> 4808
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4808
uccaauucca ugauaccugg a 21
<210> 4809
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4809
uccacaaaca cccaaaugca c 21
<210> 4810
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4810
uccacaaaca cccaacccau a 21
<210> 4811
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4811
uccaccauac cuggauucca c 21
<210> 4812
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4812
uccaccccag aaccagcccu g 21
<210> 4813
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4813
uccacgauac cuggauucca c 21
<210> 4814
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4814
uccacggaug ugagacgcca g 21
<210> 4815
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4815
uccagaccca caaucgccua a 21
<210> 4816
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4816
uccagagacu uggaggaguu g 21
<210> 4817
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4817
uccaggacca gaggcugggg c 21
<210> 4818
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4818
uccagguauc auggaauugg a 21
<210> 4819
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4819
uccagguauc guggaauugg a 21
<210> 4820
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4820
uccagguaug guggaauugg a 21
<210> 4821
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4821
uccagguccc uguagaauuc a 21
<210> 4822
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4822
uccagugacu gccggcgcac u 21
<210> 4823
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4823
uccagugagg acuggcgucu c 21
<210> 4824
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4824
uccaugauac cuggauucca c 21
<210> 4825
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4825
ucccaaacuc caauuccacc a 21
<210> 4826
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4826
ucccaaaucu uguaaagucc a 21
<210> 4827
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4827
ucccaaccug cuaaccccug a 21
<210> 4828
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4828
ucccaccaaa cccugaaccu u 21
<210> 4829
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4829
ucccacucuc agccagcugg g 21
<210> 4830
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4830
uccccaagcu gcaaacuccc a 21
<210> 4831
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4831
ucccggacac ccucaacucu a 21
<210> 4832
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4832
ucccuguaga auucagggug c 21
<210> 4833
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4833
uccgggaguu ugaguguuua c 21
<210> 4834
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4834
uccguggaau gacaagccca c 21
<210> 4835
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4835
uccucacugg agucagcgcc u 21
<210> 4836
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4836
uccuccaagu cucuggacuu c 21
<210> 4837
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4837
uccucuccag gaccagaggc u 21
<210> 4838
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4838
uccugcccau gugguugaga c 21
<210> 4839
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4839
uccuggagag gauccaguga c 21
<210> 4840
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4840
ucgccuaaac ccacacaugc c 21
<210> 4841
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4841
ucggagguuu ggacuuuaca a 21
<210> 4842
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4842
ucggaguggg gcacgggagu g 21
<210> 4843
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4843
ucggguucau guauaguugg g 21
<210> 4844
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4844
ucguugccca ggcuuucaaa g 21
<210> 4845
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4845
ucuaaaccuc aaaucuuaga g 21
<210> 4846
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4846
ucuaagauuu gagguuuaga g 21
<210> 4847
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4847
ucuacaggga ccuggacccc c 21
<210> 4848
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4848
ucuacccaca aacagggcug g 21
<210> 4849
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4849
ucuaccuacc caaacccaca u 21
<210> 4850
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4850
ucuaccucuc uaaacacucc a 21
<210> 4851
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4851
ucuagaaaca ucccaaacuc c 21
<210> 4852
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4852
ucuagaauug aggucaucug u 21
<210> 4853
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4853
ucucaaccac augggcagga c 21
<210> 4854
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4854
ucucacaucc guggaaugac a 21
<210> 4855
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4855
ucucagccag cugggccugg c 21
<210> 4856
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4856
ucucaggcag cccaaaugua u 21
<210> 4857
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4857
ucuccaggac cagaggcugg g 21
<210> 4858
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4858
ucucuggacu uccagaccca c 21
<210> 4859
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4859
ucucugggca cugccaccgu c 21
<210> 4860
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4860
ucugcuucca ccccagaacc a 21
<210> 4861
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4861
ucuggaaguc cagagacuug g 21
<210> 4862
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4862
ucuggacuuc cagacccaca a 21
<210> 4863
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4863
ucugggcacu gccaccgucu c 21
<210> 4864
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4864
ucuggggugg aagcagacau u 21
<210> 4865
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4865
ucugguccug gagaggaucc a 21
<210> 4866
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4866
ucuguugguu uaggguguau g 21
<210> 4867
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4867
ucuuagagca ccccaaaccc a 21
<210> 4868
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4868
ucuucucugg gcacugccac c 21
<210> 4869
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4869
ucuuguaaag uccaaaccuc c 21
<210> 4870
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4870
ucuuuaaacc cacacugaaa a 21
<210> 4871
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4871
ugaaaauugc aaguccccaa g 21
<210> 4872
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4872
ugaaagccug ggcaacgagg g 21
<210> 4873
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4873
ugaacaccac auacacccua a 21
<210> 4874
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4874
ugaacccgaa guagccaauc u 21
<210> 4875
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4875
ugaaccuucc aaccagcguc a 21
<210> 4876
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4876
ugaauccaca aacacccaaa u 21
<210> 4877
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4877
ugaauucuac agggaccugg a 21
<210> 4878
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4878
ugacaagccc acucccgugc c 21
<210> 4879
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4879
ugaccucaau ucuagaaaca u 21
<210> 4880
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4880
ugacgcuggu uggaagguuc a 21
<210> 4881
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4881
ugacuccagu gaggacuggc g 21
<210> 4882
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4882
ugacucccac ucucagccag c 21
<210> 4883
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4883
ugacucuacc cacaaacagg g 21
<210> 4884
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4884
ugacugccgg cgcacuugcc a 21
<210> 4885
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4885
ugagacgcca guccucacug g 21
<210> 4886
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4886
ugagacggug gcagugccca g 21
<210> 4887
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4887
ugagaguggg agucauggug g 21
<210> 4888
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4888
ugagaguuug gguguuuaug g 21
<210> 4889
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4889
ugaggacugg cgucucacau c 21
<210> 4890
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4890
ugaggguguc cgggaguuug a 21
<210> 4891
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4891
ugaggucauc uguugguuua g 21
<210> 4892
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4892
ugagguuuag agguuuuggc g 21
<210> 4893
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4893
ugagugguua ugacucuacc c 21
<210> 4894
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4894
ugauaccugg auuccacaaa c 21
<210> 4895
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4895
ugauuauaua uauuugggcu g 21
<210> 4896
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4896
ugauuguauu uauuaggacu g 21
<210> 4897
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4897
ugcaaacucc caaaucuugu a 21
<210> 4898
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4898
ugcaaguccc caagcugcaa a 21
<210> 4899
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4899
ugcaauuuuc aguguggguu u 21
<210> 4900
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4900
ugcacccuga auucuacagg g 21
<210> 4901
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4901
ugcagcuugg ggacuugcaa u 21
<210> 4902
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4902
ugcauuuggg uguuugugga u 21
<210> 4903
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4903
ugccaaugcc auuaucuucu c 21
<210> 4904
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4904
ugccaccguc ucaaccacau g 21
<210> 4905
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4905
ugccaggcgc ugacuccagu g 21
<210> 4906
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4906
ugccauuauc uucucugggc a 21
<210> 4907
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4907
ugcccagaga agauaauggc a 21
<210> 4908
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4908
ugcccaggcu uucaaaggcc a 21
<210> 4909
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4909
ugcccaugug guugagacgg u 21
<210> 4910
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4910
ugccccaaac ccuaaaccuc u 21
<210> 4911
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4911
ugccccaacu auacaugaac c 21
<210> 4912
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4912
ugccccagcc ucugguccug g 21
<210> 4913
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4913
ugccggcgca cuugccaaug c 21
<210> 4914
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4914
ugccugagag uuuggguguu u 21
<210> 4915
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4915
ugcgccggca gucacuggau c 21
<210> 4916
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4916
ugcuaacccc ugaauccaca a 21
<210> 4917
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4917
ugcucuaaga uuugagguuu a 21
<210> 4918
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4918
ugcugacgcu gguuggaagg u 21
<210> 4919
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4919
ugcuguccug cccauguggu u 21
<210> 4920
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4920
ugcuuccacc ccagaaccag c 21
<210> 4921
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4921
uggaagcaga cauuuggggg u 21
<210> 4922
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4922
uggaagguuc aggguuuggu g 21
<210> 4923
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4923
uggaagucca gagacuugga g 21
<210> 4924
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4924
uggaauccag guaucaugga a 21
<210> 4925
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4925
uggaauccag guaucgugga a 21
<210> 4926
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4926
uggaauccag guauggugga a 21
<210> 4927
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4927
uggaaugaca agcccacucc c 21
<210> 4928
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4928
uggaauugga guuugggaug u 21
<210> 4929
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4929
uggaccccca aaugucugcu u 21
<210> 4930
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4930
uggacuucca gacccacaau c 21
<210> 4931
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4931
uggacuuuac aagauuuggg a 21
<210> 4932
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4932
uggagacucg gagguuugga c 21
<210> 4933
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4933
uggagaggau ccagugacug c 21
<210> 4934
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4934
uggaggaguu gcugacgcug g 21
<210> 4935
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4935
uggagguuua ggcuggguuu g 21
<210> 4936
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4936
uggagucagc gccuggcagg c 21
<210> 4937
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4937
uggaguguuu agagagguag a 21
<210> 4938
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4938
uggaguuugg gauguuucua g 21
<210> 4939
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4939
uggauccucu ccaggaccag a 21
<210> 4940
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4940
uggauucagg gguuagcagg u 21
<210> 4941
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4941
uggauuccac aaacacccaa c 21
<210> 4942
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4942
uggcaagugc gccggcaguc a 21
<210> 4943
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4943
uggcaggcug ugugccccag c 21
<210> 4944
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4944
uggcagugcc cagagaagau a 21
<210> 4945
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4945
uggcauuggc aagugcgccg g 21
<210> 4946
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4946
uggcccccuc guugcccagg c 21
<210> 4947
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4947
uggccuuuga aagccugggc a 21
<210> 4948
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4948
uggcguaugu ggguuugggu a 21
<210> 4949
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4949
uggcgucuca cauccgugga a 21
<210> 4950
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4950
uggcuacuuc ggguucaugu a 21
<210> 4951
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4951
uggcugagag ugggagucau g 21
<210> 4952
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4952
uggcugcugu ccugcccaug u 21
<210> 4953
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4953
ugggaaugau uauauauauu u 21
<210> 4954
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4954
ugggagucau gguggcugcu g 21
<210> 4955
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4955
ugggaguuug cagcuugggg a 21
<210> 4956
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4956
ugggaugugu ggcccccucg u 21
<210> 4957
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4957
ugggauguuu cuagaauuga g 21
<210> 4958
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4958
ugggcaacga gggggccaca c 21
<210> 4959
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4959
ugggcacugc caccgucuca a 21
<210> 4960
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4960
ugggcaggac agcagccacc a 21
<210> 4961
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4961
ugggccuggc cuuugaaagc c 21
<210> 4962
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4962
ugggcugccu gagaguuugg g 21
<210> 4963
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4963
ugggcuuguc auuccacgga u 21
<210> 4964
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4964
uggggacuug caauuuucag u 21
<210> 4965
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4965
uggggcacac agccugccag g 21
<210> 4966
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4966
uggggcacgg gagugggcuu g 21
<210> 4967
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4967
uggggcaugu guggguuuag g 21
<210> 4968
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4968
uggggcauuu ggaauugauu g 21
<210> 4969
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4969
ugggggucca ggucccugua g 21
<210> 4970
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4970
uggggugcuc uaagauuuga g 21
<210> 4971
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4971
ugggguggaa gcagacauuu g 21
<210> 4972
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4972
ugggguguug gagguuuagg c 21
<210> 4973
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4973
uggguaggua gaguugaggg u 21
<210> 4974
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4974
ugggucugga aguccagaga c 21
<210> 4975
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4975
uggguguuua uggguugggu g 21
<210> 4976
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4976
uggguguuug uggaauccag g 21
<210> 4977
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4977
uggguguuug uggauucagg g 21
<210> 4978
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4978
uggguugggu guuuguggaa u 21
<210> 4979
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4979
uggguuuaaa gauuggcuac u 21
<210> 4980
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4980
uggguuuagg cgauuguggg u 21
<210> 4981
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4981
uggguuuggg gugcucuaag a 21
<210> 4982
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4982
uggguuuggg uagguagagu u 21
<210> 4983
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4983
ugguccugga gaggauccag u 21
<210> 4984
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4984
ugguggaauu ggaguuuggg a 21
<210> 4985
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4985
ugguggcugc uguccugccc a 21
<210> 4986
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4986
uggugggaug uguggccccc u 21
<210> 4987
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4987
ugguguucau ugauggugcg g 21
<210> 4988
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4988
ugguuaugac ucuacccaca a 21
<210> 4989
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4989
ugguucuggg guggaagcag a 21
<210> 4990
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4990
ugguugagac gguggcagug c 21
<210> 4991
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4991
ugguuggaag guucaggguu u 21
<210> 4992
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4992
ugguuuaggg uguauguggu g 21
<210> 4993
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4993
uguaaacacu caaacucccg g 21
<210> 4994
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4994
uguaaagucc aaaccuccga g 21
<210> 4995
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4995
uguagaauuc agggugcauu u 21
<210> 4996
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4996
uguauaguug gggcauuugg a 21
<210> 4997
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4997
uguauauaaa cuccaauucc a 21
<210> 4998
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4998
uguauguggu guucauugau g 21
<210> 4999
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 4999
uguauuuauu aggacugggg u 21
<210> 5000
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5000
ugucauucca cggaugugag a 21
<210> 5001
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5001
uguccgggag uuugaguguu u 21
<210> 5002
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5002
uguccugccc augugguuga g 21
<210> 5003
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5003
ugucggagug gggcacggga g 21
<210> 5004
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5004
ugucugcuuc caccccagaa c 21
<210> 5005
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5005
ugugagacgc caguccucac u 21
<210> 5006
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5006
ugugccccag ccucuggucc u 21
<210> 5007
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5007
uguggaaucc agguaucaug g 21
<210> 5008
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5008
uguggaaucc agguaucgug g 21
<210> 5009
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5009
uguggaaucc agguauggug g 21
<210> 5010
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5010
uguggauuca gggguuagca g 21
<210> 5011
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5011
uguggccccc ucguugccca g 21
<210> 5012
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5012
ugugggucug gaaguccaga g 21
<210> 5013
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5013
uguggguuua aagauuggcu a 21
<210> 5014
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5014
uguggguuua ggcgauugug g 21
<210> 5015
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5015
uguggguuug gguagguaga g 21
<210> 5016
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5016
ugugguguuc auugauggug c 21
<210> 5017
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5017
ugugguugag acgguggcag u 21
<210> 5018
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5018
ugugugcccc agccucuggu c 21
<210> 5019
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5019
uguguggccc ccucguugcc c 21
<210> 5020
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5020
uguguggguu uaggcgauug u 21
<210> 5021
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5021
uguuggaggu uuaggcuggg u 21
<210> 5022
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5022
uguugguuua ggguguaugu g 21
<210> 5023
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5023
uguuuagaga gguagagguu u 21
<210> 5024
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5024
uguuuauggg uuggguguuu g 21
<210> 5025
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5025
uguuucuaga auugagguca u 21
<210> 5026
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5026
uguuugugga auccagguau c 21
<210> 5027
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5027
uguuugugga auccagguau g 21
<210> 5028
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5028
uguuugugga uucagggguu a 21
<210> 5029
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5029
uguuuguggg uagagucaua a 21
<210> 5030
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5030
uuaaacccac acugaaaauu g 21
<210> 5031
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5031
uuaaagauug gcuacuucgg g 21
<210> 5032
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5032
uuacaagauu ugggaguuug c 21
<210> 5033
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5033
uuacauauuu ggaguguuua g 21
<210> 5034
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5034
uuagagaggu agagguuuag g 21
<210> 5035
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5035
uuagagcacc ccaaacccag c 21
<210> 5036
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5036
uuagagguuu uggcguaugu g 21
<210> 5037
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5037
uuaggacugg gguguuggag g 21
<210> 5038
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5038
uuaggcgauu gugggucugg a 21
<210> 5039
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5039
uuaggcuggg uuuggggugc u 21
<210> 5040
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5040
uuagggugua ugugguguuc a 21
<210> 5041
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5041
uuaggguuug gggcaugugu g 21
<210> 5042
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5042
uuauauacau uugggcugcc u 21
<210> 5043
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5043
uuauauauau uugggcugcc u 21
<210> 5044
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5044
uuaucuucuc ugggcacugc c 21
<210> 5045
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5045
uuaugacucu acccacaaac a 21
<210> 5046
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5046
uuauggguug gguguuugug g 21
<210> 5047
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5047
uuauuaggac ugggguguug g 21
<210> 5048
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5048
uucaaaggcc aggcccagcu g 21
<210> 5049
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5049
uucagggguu agcagguugg g 21
<210> 5050
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5050
uucagggugc auuugggugu u 21
<210> 5051
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5051
uucaggguuu ggugggaugu g 21
<210> 5052
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5052
uucagugugg guuuaaagau u 21
<210> 5053
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5053
uucauguaua guuggggcau u 21
<210> 5054
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5054
uuccaaaugc cccaacuaua c 21
<210> 5055
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5055
uuccaaccag cgucagcaac u 21
<210> 5056
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5056
uuccacaaac acccaaccca u 21
<210> 5057
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5057
uuccaccaua ccuggauucc a 21
<210> 5058
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5058
uuccacccca gaaccagccc u 21
<210> 5059
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5059
uuccacgaua ccuggauucc a 21
<210> 5060
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5060
uuccacggau gugagacgcc a 21
<210> 5061
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5061
uuccagaccc acaaucgccu a 21
<210> 5062
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5062
uuccaugaua ccuggauucc a 21
<210> 5063
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5063
uucccaaccu gcuaaccccu g 21
<210> 5064
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5064
uucggguuca uguauaguug g 21
<210> 5065
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5065
uucuacaggg accuggaccc c 21
<210> 5066
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5066
uucuagaaac aucccaaacu c 21
<210> 5067
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5067
uucuagaauu gaggucaucu g 21
<210> 5068
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5068
uucucugggc acugccaccg u 21
<210> 5069
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5069
uucuggggug gaagcagaca u 21
<210> 5070
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5070
uugaaagccu gggcaacgag g 21
<210> 5071
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5071
uugagacggu ggcagugccc a 21
<210> 5072
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5072
uugagggugu ccgggaguuu g 21
<210> 5073
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5073
uugaggucau cuguugguuu a 21
<210> 5074
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5074
uugagguuua gagguuuugg c 21
<210> 5075
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5075
uugauuguau uuauuaggac u 21
<210> 5076
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5076
uugcaagucc ccaagcugca a 21
<210> 5077
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5077
uugcaauuuu cagugugggu u 21
<210> 5078
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5078
uugcagcuug gggacuugca a 21
<210> 5079
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5079
uugccaaugc cauuaucuuc u 21
<210> 5080
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5080
uugcccaggc uuucaaaggc c 21
<210> 5081
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5081
uugcugacgc ugguuggaag g 21
<210> 5082
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5082
uuggaagguu caggguuugg u 21
<210> 5083
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5083
uuggacuuua caagauuugg g 21
<210> 5084
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5084
uuggagacuc ggagguuugg a 21
<210> 5085
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5085
uuggaggagu ugcugacgcu g 21
<210> 5086
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5086
uuggagguuu aggcuggguu u 21
<210> 5087
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5087
uuggaguguu uagagaggua g 21
<210> 5088
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5088
uuggaguuug ggauguuucu a 21
<210> 5089
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5089
uuggcaagug cgccggcagu c 21
<210> 5090
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5090
uuggcguaug uggguuuggg u 21
<210> 5091
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5091
uuggcuacuu cggguucaug u 21
<210> 5092
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5092
uugggaguuu gcagcuuggg g 21
<210> 5093
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5093
uugggauguu ucuagaauug a 21
<210> 5094
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5094
uugggcugcc ugagaguuug g 21
<210> 5095
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5095
uuggggacuu gcaauuuuca g 21
<210> 5096
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5096
uuggggcaug uguggguuua g 21
<210> 5097
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5097
uuggggcauu uggaauugau u 21
<210> 5098
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5098
uugggggucc aggucccugu a 21
<210> 5099
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5099
uuggggugcu cuaagauuug a 21
<210> 5100
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5100
uuggguaggu agaguugagg g 21
<210> 5101
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5101
uuggguguuu auggguuggg u 21
<210> 5102
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5102
uuggguguuu guggaaucca g 21
<210> 5103
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5103
uuggguguuu guggauucag g 21
<210> 5104
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5104
uuggugggau guguggcccc c 21
<210> 5105
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5105
uugguuuagg guguaugugg u 21
<210> 5106
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5106
uuguaaaguc caaaccuccg a 21
<210> 5107
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5107
uuguauuuau uaggacuggg g 21
<210> 5108
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5108
uugucauucc acggauguga g 21
<210> 5109
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5109
uuguggaauc cagguaucau g 21
<210> 5110
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5110
uuguggaauc cagguaucgu g 21
<210> 5111
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5111
uuguggaauc cagguauggu g 21
<210> 5112
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5112
uuguggauuc agggguuagc a 21
<210> 5113
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5113
uugugggucu ggaaguccag a 21
<210> 5114
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5114
uuuaaaccca cacugaaaau u 21
<210> 5115
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5115
uuuaaagauu ggcuacuucg g 21
<210> 5116
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5116
uuuacaagau uugggaguuu g 21
<210> 5117
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5117
uuuacauauu uggaguguuu a 21
<210> 5118
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5118
uuuagagagg uagagguuua g 21
<210> 5119
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5119
uuuagagguu uuggcguaug u 21
<210> 5120
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5120
uuuaggcgau ugugggucug g 21
<210> 5121
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5121
uuuaggcugg guuuggggug c 21
<210> 5122
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5122
uuuagggugu augugguguu c 21
<210> 5123
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5123
uuuaggguuu ggggcaugug u 21
<210> 5124
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5124
uuuauauaca uuugggcugc c 21
<210> 5125
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5125
uuuauggguu ggguguuugu g 21
<210> 5126
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5126
uuuauuagga cugggguguu g 21
<210> 5127
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5127
uuucaaaggc caggcccagc u 21
<210> 5128
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5128
uuucagugug gguuuaaaga u 21
<210> 5129
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5129
uuucuagaau ugaggucauc u 21
<210> 5130
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5130
uuugaaagcc ugggcaacga g 21
<210> 5131
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5131
uuugagguuu agagguuuug g 21
<210> 5132
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5132
uuugcagcuu ggggacuugc a 21
<210> 5133
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5133
uuuggacuuu acaagauuug g 21
<210> 5134
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5134
uuuggagacu cggagguuug g 21
<210> 5135
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5135
uuuggagugu uuagagaggu a 21
<210> 5136
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5136
uuuggcguau guggguuugg g 21
<210> 5137
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5137
uuugggaguu ugcagcuugg g 21
<210> 5138
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5138
uuugggaugu uucuagaauu g 21
<210> 5139
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5139
uuugggcugc cugagaguuu g 21
<210> 5140
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5140
uuuggggcau guguggguuu a 21
<210> 5141
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5141
uuuggggguc caggucccug u 21
<210> 5142
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5142
uuuggggugc ucuaagauuu g 21
<210> 5143
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5143
uuuggguagg uagaguugag g 21
<210> 5144
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5144
uuuggguguu uauggguugg g 21
<210> 5145
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5145
uuuggguguu uguggauuca g 21
<210> 5146
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5146
uuugguggga uguguggccc c 21
<210> 5147
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5147
uuuguggaau ccagguauca u 21
<210> 5148
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5148
uuuguggaau ccagguaucg u 21
<210> 5149
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5149
uuuguggaau ccagguaugg u 21
<210> 5150
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5150
uuuguggauu cagggguuag c 21
<210> 5151
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5151
uuugugggua gagucauaac c 21
<210> 5152
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5152
uuuucagugu ggguuuaaag a 21
<210> 5153
<211> 21
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5153
uuuuggcgua uguggguuug g 21
<210> 5154
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5154
aaaaccucua aaccucaaau cu 22
<210> 5155
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5155
aaaauugcaa guccccaagc ug 22
<210> 5156
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5156
aaacacccaa acucucaggc ag 22
<210> 5157
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5157
aaacacccaa augcacccug aa 22
<210> 5158
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5158
aaacacccaa cccauaaaca cc 22
<210> 5159
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5159
aaacacucaa acucccggac ac 22
<210> 5160
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5160
aaacagggcu gguucugggg ug 22
<210> 5161
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5161
aaacauccca aacuccaauu cc 22
<210> 5162
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5162
aaaccaacag augaccucaa uu 22
<210> 5163
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5163
aaacccacac augccccaaa cc 22
<210> 5164
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5164
aaacccacac ugaaaauugc aa 22
<210> 5165
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5165
aaacccacau acgccaaaac cu 22
<210> 5166
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5166
aaacccagcc uaaaccucca ac 22
<210> 5167
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5167
aaacccuaaa ccucuaccuc uc 22
<210> 5168
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5168
aaacccugaa ccuuccaacc ag 22
<210> 5169
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5169
aaaccucaaa ucuuagagca cc 22
<210> 5170
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5170
aaaccuccaa caccccaguc cu 22
<210> 5171
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5171
aaaccucuaa accucaaauc uu 22
<210> 5172
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5172
aaaccucuac cucucuaaac ac 22
<210> 5173
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5173
aaacucacag gcagcccaaa ua 22
<210> 5174
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5174
aaacucacag gcagcccaaa ug 22
<210> 5175
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5175
aaacuccaau uccaccauac cu 22
<210> 5176
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5176
aaacuccaau uccacgauac cu 22
<210> 5177
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5177
aaacuccaau uccaugauac cu 22
<210> 5178
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5178
aaacucccaa aucuuguaaa gu 22
<210> 5179
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5179
aaacucccgg acacccucaa cu 22
<210> 5180
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5180
aaacucucag gcagcccaaa ug 22
<210> 5181
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5181
aaagauuggc uacuucgggu uc 22
<210> 5182
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5182
aaagccuggg caacgagggg gc 22
<210> 5183
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5183
aaaggccagg cccagcuggc ug 22
<210> 5184
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5184
aaauacaauc aauuccaaau gc 22
<210> 5185
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5185
aaauauguaa acacucaaac uc 22
<210> 5186
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5186
aaaucuuaga gcaccccaaa cc 22
<210> 5187
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5187
aaaucuugua aaguccaaac cu 22
<210> 5188
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5188
aaaugcaccc ugaauucuac ag 22
<210> 5189
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5189
aaaugcccca acuauacaug aa 22
<210> 5190
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5190
aaaugucugc uuccacccca ga 22
<210> 5191
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5191
aaauugcaag uccccaagcu gc 22
<210> 5192
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5192
aacaccacau acacccuaaa cc 22
<210> 5193
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5193
aacacccaaa cucucaggca gc 22
<210> 5194
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5194
aacacccaaa ugcacccuga au 22
<210> 5195
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5195
aacacccaac ccauaaacac cc 22
<210> 5196
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5196
aacaccccag uccuaauaaa ua 22
<210> 5197
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5197
aacacucaaa cucccggaca cc 22
<210> 5198
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5198
aacacuccaa auauguaaac ac 22
<210> 5199
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5199
aacagaugac cucaauucua ga 22
<210> 5200
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5200
aacagggcug guucuggggu gg 22
<210> 5201
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5201
aacaucccaa acuccaauuc ca 22
<210> 5202
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5202
aaccaacaga ugaccucaau uc 22
<210> 5203
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5203
aaccacaugg gcaggacagc ag 22
<210> 5204
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5204
aaccagcccu guuugugggu ag 22
<210> 5205
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5205
aaccagcguc agcaacuccu cc 22
<210> 5206
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5206
aacccacaca ugccccaaac cc 22
<210> 5207
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5207
aacccacacu gaaaauugca ag 22
<210> 5208
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5208
aacccacaua cgccaaaacc uc 22
<210> 5209
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5209
aacccagccu aaaccuccaa ca 22
<210> 5210
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5210
aacccauaaa cacccaaacu cu 22
<210> 5211
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5211
aaccccugaa uccacaaaca cc 22
<210> 5212
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5212
aacccgaagu agccaaucuu ua 22
<210> 5213
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5213
aacccuaaac cucuaccucu cu 22
<210> 5214
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5214
aacccugaac cuuccaacca gc 22
<210> 5215
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5215
aaccgcacca ucaaugaaca cc 22
<210> 5216
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5216
aaccucaaau cuuagagcac cc 22
<210> 5217
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5217
aaccuccaac accccagucc ua 22
<210> 5218
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5218
aaccucuaaa ccucaaaucu ua 22
<210> 5219
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5219
aaccucuacc ucucuaaaca cu 22
<210> 5220
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5220
aaccugcuaa ccccugaauc ca 22
<210> 5221
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5221
aaccuuccaa ccagcgucag ca 22
<210> 5222
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5222
aacgaggggg ccacacaucc ca 22
<210> 5223
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5223
aacuauacau gaacccgaag ua 22
<210> 5224
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5224
aacucacagg cagcccaaau au 22
<210> 5225
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5225
aacucacagg cagcccaaau gu 22
<210> 5226
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5226
aacuccaauu ccaccauacc ug 22
<210> 5227
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5227
aacuccaauu ccacgauacc ug 22
<210> 5228
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5228
aacuccaauu ccaugauacc ug 22
<210> 5229
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5229
aacucccaaa ucuuguaaag uc 22
<210> 5230
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5230
aacucccgga cacccucaac uc 22
<210> 5231
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5231
aacuccucca agucucugga cu 22
<210> 5232
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5232
aacucuaccu acccaaaccc ac 22
<210> 5233
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5233
aacucucagg cagcccaaau gu 22
<210> 5234
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5234
aagauaaugg cauuggcaag ug 22
<210> 5235
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5235
aagauuggcu acuucggguu ca 22
<210> 5236
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5236
aagauuugag guuuagaggu uu 22
<210> 5237
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5237
aagauuuggg aguuugcagc uu 22
<210> 5238
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5238
aagcagacau uugggggucc ag 22
<210> 5239
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5239
aagcccacuc ccgugcccca cu 22
<210> 5240
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5240
aagccugggc aacgaggggg cc 22
<210> 5241
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5241
aagcugcaaa cucccaaauc uu 22
<210> 5242
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5242
aaggccaggc ccagcuggcu ga 22
<210> 5243
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5243
aagguucagg guuugguggg au 22
<210> 5244
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5244
aaguagccaa ucuuuaaacc ca 22
<210> 5245
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5245
aaguccagag acuuggagga gu 22
<210> 5246
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5246
aaguccccaa gcugcaaacu cc 22
<210> 5247
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5247
aagucucugg acuuccagac cc 22
<210> 5248
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5248
aagugcgccg gcagucacug ga 22
<210> 5249
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5249
aauaaauaca aucaauucca aa 22
<210> 5250
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5250
aauacaauca auuccaaaug cc 22
<210> 5251
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5251
aauauguaaa cacucaaacu cc 22
<210> 5252
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5252
aaucaauucc aaaugcccca ac 22
<210> 5253
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5253
aaucauuccc aaccugcuaa cc 22
<210> 5254
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5254
aauccacaaa cacccaaaug ca 22
<210> 5255
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5255
aauccaggua ucauggaauu gg 22
<210> 5256
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5256
aauccaggua ucguggaauu gg 22
<210> 5257
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5257
aauccaggua ugguggaauu gg 22
<210> 5258
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5258
aaucgccuaa acccacacau gc 22
<210> 5259
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5259
aaucuuagag caccccaaac cc 22
<210> 5260
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5260
aaucuuguaa aguccaaacc uc 22
<210> 5261
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5261
aaucuuuaaa cccacacuga aa 22
<210> 5262
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5262
aaugaacacc acauacaccc ua 22
<210> 5263
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5263
aaugacaagc ccacucccgu gc 22
<210> 5264
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5264
aaugauuaua uauauuuggg cu 22
<210> 5265
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5265
aaugcacccu gaauucuaca gg 22
<210> 5266
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5266
aaugccauua ucuucucugg gc 22
<210> 5267
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5267
aaugccccaa cuauacauga ac 22
<210> 5268
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5268
aauggcauug gcaagugcgc cg 22
<210> 5269
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5269
aaugucugcu uccaccccag aa 22
<210> 5270
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5270
aauucagggu gcauuugggu gu 22
<210> 5271
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5271
aauuccaaau gccccaacua ua 22
<210> 5272
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5272
aauuccacca uaccuggauu cc 22
<210> 5273
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5273
aauuccacga uaccuggauu cc 22
<210> 5274
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5274
aauuccauga uaccuggauu cc 22
<210> 5275
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5275
aauucuacag ggaccuggac cc 22
<210> 5276
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5276
aauucuagaa acaucccaaa cu 22
<210> 5277
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5277
aauugagguc aucuguuggu uu 22
<210> 5278
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5278
aauugauugu auuuauuagg ac 22
<210> 5279
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5279
aauugcaagu ccccaagcug ca 22
<210> 5280
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5280
aauuggaguu ugggauguuu cu 22
<210> 5281
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5281
aauuuucagu guggguuuaa ag 22
<210> 5282
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5282
acaaacaccc aaaugcaccc ug 22
<210> 5283
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5283
acaaacaccc aacccauaaa ca 22
<210> 5284
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5284
acaaacaggg cugguucugg gg 22
<210> 5285
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5285
acaagauuug ggaguuugca gc 22
<210> 5286
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5286
acaagcccac ucccgugccc ca 22
<210> 5287
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5287
acaaucaauu ccaaaugccc ca 22
<210> 5288
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5288
acaaucgccu aaacccacac au 22
<210> 5289
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5289
acacagccug ccaggcgcug ac 22
<210> 5290
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5290
acacauccca ccaaacccug aa 22
<210> 5291
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5291
acacaugccc caaacccuaa ac 22
<210> 5292
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5292
acaccacaua cacccuaaac ca 22
<210> 5293
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5293
acacccaaac ucacaggcag cc 22
<210> 5294
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5294
acacccaaac ucucaggcag cc 22
<210> 5295
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5295
acacccaaau gcacccugaa uu 22
<210> 5296
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5296
acacccaacc cauaaacacc ca 22
<210> 5297
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5297
acaccccagu ccuaauaaau ac 22
<210> 5298
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5298
acacccuaaa ccaacagaug ac 22
<210> 5299
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5299
acacccucaa cucuaccuac cc 22
<210> 5300
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5300
acacucaaac ucccggacac cc 22
<210> 5301
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5301
acacuccaaa uauguaaaca cu 22
<210> 5302
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5302
acacugaaaa uugcaagucc cc 22
<210> 5303
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5303
acagaugacc ucaauucuag aa 22
<210> 5304
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5304
acagcagcca ccaugacucc ca 22
<210> 5305
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5305
acagccugcc aggcgcugac uc 22
<210> 5306
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5306
acaggcagcc caaauauaua ua 22
<210> 5307
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5307
acaggcagcc caaauguaua ua 22
<210> 5308
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5308
acagggaccu ggacccccaa au 22
<210> 5309
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5309
acagggcugg uucuggggug ga 22
<210> 5310
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5310
acauacaccc uaaaccaaca ga 22
<210> 5311
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5311
acauacgcca aaaccucuaa ac 22
<210> 5312
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5312
acauauuugg aguguuuaga ga 22
<210> 5313
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5313
acaucccaaa cuccaauucc ac 22
<210> 5314
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5314
acaucccacc aaacccugaa cc 22
<210> 5315
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5315
acauccgugg aaugacaagc cc 22
<210> 5316
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5316
acaugaaccc gaaguagcca au 22
<210> 5317
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5317
acaugcccca aacccuaaac cu 22
<210> 5318
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5318
acaugggcag gacagcagcc ac 22
<210> 5319
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5319
acauuugggc ugccugagag uu 22
<210> 5320
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5320
acauuugggc ugccugugag uu 22
<210> 5321
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5321
acauuugggg guccaggucc cu 22
<210> 5322
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5322
accaaacccu gaaccuucca ac 22
<210> 5323
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5323
accaacagau gaccucaauu cu 22
<210> 5324
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5324
accacauaca cccuaaacca ac 22
<210> 5325
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5325
accacauggg caggacagca gc 22
<210> 5326
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5326
accagaggcu ggggcacaca gc 22
<210> 5327
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5327
accagcccug uuugugggua ga 22
<210> 5328
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5328
accagcguca gcaacuccuc ca 22
<210> 5329
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5329
accauaccug gauuccacaa ac 22
<210> 5330
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5330
accaucaaug aacaccacau ac 22
<210> 5331
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5331
accaugacuc ccacucucag cc 22
<210> 5332
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5332
acccaaaccc acauacgcca aa 22
<210> 5333
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5333
acccaaacuc acaggcagcc ca 22
<210> 5334
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5334
acccaaacuc ucaggcagcc ca 22
<210> 5335
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5335
acccaaaugc acccugaauu cu 22
<210> 5336
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5336
acccaaccca uaaacaccca aa 22
<210> 5337
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5337
acccacaaac agggcugguu cu 22
<210> 5338
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5338
acccacaauc gccuaaaccc ac 22
<210> 5339
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5339
acccacacau gccccaaacc cu 22
<210> 5340
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5340
acccacacug aaaauugcaa gu 22
<210> 5341
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5341
acccacauac gccaaaaccu cu 22
<210> 5342
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5342
acccagccua aaccuccaac ac 22
<210> 5343
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5343
acccauaaac acccaaacuc uc 22
<210> 5344
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5344
accccaaacc cagccuaaac cu 22
<210> 5345
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5345
accccagaac cagcccuguu ug 22
<210> 5346
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5346
accccagucc uaauaaauac aa 22
<210> 5347
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5347
acccccaaau gucugcuucc ac 22
<210> 5348
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5348
acccccaacc gcaccaucaa ug 22
<210> 5349
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5349
accccugaau ccacaaacac cc 22
<210> 5350
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5350
acccgaagua gccaaucuuu aa 22
<210> 5351
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5351
acccuaaacc aacagaugac cu 22
<210> 5352
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5352
acccuaaacc ucuaccucuc ua 22
<210> 5353
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5353
acccucaacu cuaccuaccc aa 22
<210> 5354
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5354
acccugaacc uuccaaccag cg 22
<210> 5355
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5355
acccugaauu cuacagggac cu 22
<210> 5356
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5356
accgcaccau caaugaacac ca 22
<210> 5357
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5357
accgucucaa ccacaugggc ag 22
<210> 5358
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5358
accuacccaa acccacauac gc 22
<210> 5359
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5359
accucaaauc uuagagcacc cc 22
<210> 5360
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5360
accucaauuc uagaaacauc cc 22
<210> 5361
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5361
accuccaaca ccccaguccu aa 22
<210> 5362
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5362
accucuaaac cucaaaucuu ag 22
<210> 5363
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5363
accucuaccu cucuaaacac uc 22
<210> 5364
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5364
accucucuaa acacuccaaa ua 22
<210> 5365
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5365
accugcuaac cccugaaucc ac 22
<210> 5366
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5366
accuggaccc ccaaaugucu gc 22
<210> 5367
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5367
accuggauuc cacaaacacc ca 22
<210> 5368
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5368
accuuccaac cagcgucagc aa 22
<210> 5369
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5369
acgagggggc cacacauccc ac 22
<210> 5370
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5370
acgauaccug gauuccacaa ac 22
<210> 5371
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5371
acgccaaaac cucuaaaccu ca 22
<210> 5372
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5372
acgccagucc ucacuggagu ca 22
<210> 5373
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5373
acgcugguug gaagguucag gg 22
<210> 5374
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5374
acggauguga gacgccaguc cu 22
<210> 5375
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5375
acgggagugg gcuugucauu cc 22
<210> 5376
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5376
acgguggcag ugcccagaga ag 22
<210> 5377
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5377
acuauacaug aacccgaagu ag 22
<210> 5378
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5378
acucaaacuc ccggacaccc uc 22
<210> 5379
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5379
acucacaggc agcccaaaua ua 22
<210> 5380
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5380
acucacaggc agcccaaaug ua 22
<210> 5381
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5381
acuccaaaua uguaaacacu ca 22
<210> 5382
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5382
acuccaauuc caccauaccu gg 22
<210> 5383
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5383
acuccaauuc cacgauaccu gg 22
<210> 5384
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5384
acuccaauuc caugauaccu gg 22
<210> 5385
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5385
acuccaguga ggacuggcgu cu 22
<210> 5386
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5386
acucccaaau cuuguaaagu cc 22
<210> 5387
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5387
acucccacuc ucagccagcu gg 22
<210> 5388
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5388
acucccggac acccucaacu cu 22
<210> 5389
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5389
acuccuccaa gucucuggac uu 22
<210> 5390
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5390
acucggaggu uuggacuuua ca 22
<210> 5391
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5391
acucuaccca caaacagggc ug 22
<210> 5392
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5392
acucuaccua cccaaaccca ca 22
<210> 5393
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5393
acucucagcc agcugggccu gg 22
<210> 5394
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5394
acucucaggc agcccaaaug ua 22
<210> 5395
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5395
acugaaaauu gcaagucccc aa 22
<210> 5396
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5396
acugccaccg ucucaaccac au 22
<210> 5397
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5397
acugccggcg cacuugccaa ug 22
<210> 5398
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5398
acuggaguca gcgccuggca gg 22
<210> 5399
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5399
acuggauccu cuccaggacc ag 22
<210> 5400
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5400
acuggcgucu cacauccgug ga 22
<210> 5401
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5401
acuggggugu uggagguuua gg 22
<210> 5402
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5402
acuuccagac ccacaaucgc cu 22
<210> 5403
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5403
acuucggguu cauguauagu ug 22
<210> 5404
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5404
acuugcaauu uucagugugg gu 22
<210> 5405
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5405
acuugccaau gccauuaucu uc 22
<210> 5406
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5406
acuuggagga guugcugacg cu 22
<210> 5407
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5407
acuuuacaag auuugggagu uu 22
<210> 5408
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5408
agaaacaucc caaacuccaa uu 22
<210> 5409
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5409
agaaccagcc cuguuugugg gu 22
<210> 5410
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5410
agaagauaau ggcauuggca ag 22
<210> 5411
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5411
agaauucagg gugcauuugg gu 22
<210> 5412
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5412
agaauugagg ucaucuguug gu 22
<210> 5413
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5413
agacauuugg ggguccaggu cc 22
<210> 5414
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5414
agacccacaa ucgccuaaac cc 22
<210> 5415
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5415
agacgccagu ccucacugga gu 22
<210> 5416
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5416
agacgguggc agugcccaga ga 22
<210> 5417
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5417
agacucggag guuuggacuu ua 22
<210> 5418
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5418
agacuuggag gaguugcuga cg 22
<210> 5419
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5419
agagaagaua auggcauugg ca 22
<210> 5420
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5420
agagacuugg aggaguugcu ga 22
<210> 5421
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5421
agagagguag agguuuaggg uu 22
<210> 5422
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5422
agagcacccc aaacccagcc ua 22
<210> 5423
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5423
agaggaucca gugacugccg gc 22
<210> 5424
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5424
agaggcuggg gcacacagcc ug 22
<210> 5425
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5425
agagguagag guuuaggguu ug 22
<210> 5426
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5426
agagguuuag gguuuggggc au 22
<210> 5427
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5427
agagguuuug gcguaugugg gu 22
<210> 5428
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5428
agagugggag ucaugguggc ug 22
<210> 5429
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5429
agaguugagg guguccggga gu 22
<210> 5430
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5430
agaguuuggg uguuuauggg uu 22
<210> 5431
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5431
agauaauggc auuggcaagu gc 22
<210> 5432
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5432
agaugaccuc aauucuagaa ac 22
<210> 5433
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5433
agauuggcua cuucggguuc au 22
<210> 5434
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5434
agauuugagg uuuagagguu uu 22
<210> 5435
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5435
agauuuggga guuugcagcu ug 22
<210> 5436
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5436
agcaacuccu ccaagucucu gg 22
<210> 5437
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5437
agcaccccaa acccagccua aa 22
<210> 5438
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5438
agcagacauu ugggggucca gg 22
<210> 5439
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5439
agcagccacc augacuccca cu 22
<210> 5440
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5440
agccaaucuu uaaacccaca cu 22
<210> 5441
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5441
agccaccaug acucccacuc uc 22
<210> 5442
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5442
agccagcugg gccuggccuu ug 22
<210> 5443
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5443
agcccaaaua uauauaauca uu 22
<210> 5444
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5444
agcccacucc cgugccccac uc 22
<210> 5445
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5445
agcccuguuu guggguagag uc 22
<210> 5446
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5446
agccuaaacc uccaacaccc ca 22
<210> 5447
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5447
agccucuggu ccuggagagg au 22
<210> 5448
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5448
agccugccag gcgcugacuc ca 22
<210> 5449
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5449
agccugggca acgagggggc ca 22
<210> 5450
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5450
agcgccuggc aggcugugug cc 22
<210> 5451
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5451
agcgucagca acuccuccaa gu 22
<210> 5452
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5452
agcugcaaac ucccaaaucu ug 22
<210> 5453
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5453
agcuggcuga gagugggagu ca 22
<210> 5454
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5454
agcugggccu ggccuuugaa ag 22
<210> 5455
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5455
agcuugggga cuugcaauuu uc 22
<210> 5456
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5456
aggacagcag ccaccaugac uc 22
<210> 5457
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5457
aggaccagag gcuggggcac ac 22
<210> 5458
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5458
aggacuggcg ucucacaucc gu 22
<210> 5459
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5459
aggacugggg uguuggaggu uu 22
<210> 5460
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5460
aggaguugcu gacgcugguu gg 22
<210> 5461
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5461
aggauccagu gacugccggc gc 22
<210> 5462
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5462
aggcagccca aauauauaua au 22
<210> 5463
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5463
aggccaggcc cagcuggcug ag 22
<210> 5464
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5464
aggcccagcu ggcugagagu gg 22
<210> 5465
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5465
aggcgauugu gggucuggaa gu 22
<210> 5466
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5466
aggcgcugac uccagugagg ac 22
<210> 5467
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5467
aggcuggggc acacagccug cc 22
<210> 5468
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5468
aggcuggguu uggggugcuc ua 22
<210> 5469
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5469
aggcugugug ccccagccuc ug 22
<210> 5470
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5470
aggcuuucaa aggccaggcc ca 22
<210> 5471
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5471
agggaccugg acccccaaau gu 22
<210> 5472
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5472
agggcugguu cuggggugga ag 22
<210> 5473
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5473
agggggccac acaucccacc aa 22
<210> 5474
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5474
agggguuagc agguugggaa ug 22
<210> 5475
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5475
agggugcauu uggguguuug ug 22
<210> 5476
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5476
aggguguaug ugguguucau ug 22
<210> 5477
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5477
aggguguccg ggaguuugag ug 22
<210> 5478
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5478
aggguuuggg gcaugugugg gu 22
<210> 5479
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5479
aggguuuggu gggaugugug gc 22
<210> 5480
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5480
agguagaggu uuaggguuug gg 22
<210> 5481
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5481
agguagaguu gagggugucc gg 22
<210> 5482
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5482
agguaucaug gaauuggagu uu 22
<210> 5483
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5483
agguaucgug gaauuggagu uu 22
<210> 5484
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5484
agguauggug gaauuggagu uu 22
<210> 5485
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5485
aggucaucug uugguuuagg gu 22
<210> 5486
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5486
aggucccugu agaauucagg gu 22
<210> 5487
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5487
agguucaggg uuugguggga ug 22
<210> 5488
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5488
agguugggaa ugauuauaua ua 22
<210> 5489
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5489
agguuuagag guuuuggcgu au 22
<210> 5490
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5490
agguuuaggc uggguuuggg gu 22
<210> 5491
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5491
agguuuaggg uuuggggcau gu 22
<210> 5492
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5492
agguuuggac uuuacaagau uu 22
<210> 5493
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5493
agguuuuggc guaugugggu uu 22
<210> 5494
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5494
aguagccaau cuuuaaaccc ac 22
<210> 5495
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5495
agucacugga uccucuccag ga 22
<210> 5496
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5496
agucagcgcc uggcaggcug ug 22
<210> 5497
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5497
agucauggug gcugcugucc ug 22
<210> 5498
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5498
aguccagaga cuuggaggag uu 22
<210> 5499
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5499
aguccccaag cugcaaacuc cc 22
<210> 5500
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5500
aguccucacu ggagucagcg cc 22
<210> 5501
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5501
agucucugga cuuccagacc ca 22
<210> 5502
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5502
agugacugcc ggcgcacuug cc 22
<210> 5503
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5503
agugaggacu ggcgucucac au 22
<210> 5504
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5504
agugcccaga gaagauaaug gc 22
<210> 5505
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5505
agugcgccgg cagucacugg au 22
<210> 5506
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5506
agugggaguc augguggcug cu 22
<210> 5507
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5507
agugggcuug ucauuccacg ga 22
<210> 5508
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5508
aguggggcac gggagugggc uu 22
<210> 5509
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5509
agugguuaug acucuaccca ca 22
<210> 5510
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5510
aguguggguu uaaagauugg cu 22
<210> 5511
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5511
aguguuuaca uauuuggagu gu 22
<210> 5512
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5512
aguguuuaga gagguagagg uu 22
<210> 5513
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5513
aguugagggu guccgggagu uu 22
<210> 5514
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5514
aguugcugac gcugguugga ag 22
<210> 5515
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5515
aguuggggca uuuggaauug au 22
<210> 5516
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5516
aguuuauaua cauuugggcu gc 22
<210> 5517
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5517
aguuugagug uuuacauauu ug 22
<210> 5518
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5518
aguuugcagc uuggggacuu gc 22
<210> 5519
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5519
aguuugggau guuucuagaa uu 22
<210> 5520
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5520
aguuugggug uuuauggguu gg 22
<210> 5521
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5521
auaaacaccc aaacucucag gc 22
<210> 5522
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5522
auaaacucca auuccacgau ac 22
<210> 5523
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5523
auaaacucca auuccaugau ac 22
<210> 5524
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5524
auaaauacaa ucaauuccaa au 22
<210> 5525
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5525
auaaucauuc ccaaccugcu aa 22
<210> 5526
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5526
auaauggcau uggcaagugc gc 22
<210> 5527
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5527
auacaaucaa uuccaaaugc cc 22
<210> 5528
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5528
auacacccua aaccaacaga ug 22
<210> 5529
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5529
auacaugaac ccgaaguagc ca 22
<210> 5530
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5530
auacauuugg gcugccugag ag 22
<210> 5531
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5531
auacauuugg gcugccugug ag 22
<210> 5532
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5532
auaccuggau uccacaaaca cc 22
<210> 5533
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5533
auacgccaaa accucuaaac cu 22
<210> 5534
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5534
auaguugggg cauuuggaau ug 22
<210> 5535
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5535
auauaaacuc caauuccacg au 22
<210> 5536
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5536
auauaaacuc caauuccaug au 22
<210> 5537
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5537
auauaaucau ucccaaccug cu 22
<210> 5538
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5538
auauacauuu gggcugccug ag 22
<210> 5539
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5539
auauacauuu gggcugccug ug 22
<210> 5540
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5540
auauauaauc auucccaacc ug 22
<210> 5541
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5541
auauauauuu gggcugccug ug 22
<210> 5542
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5542
auauauuugg gcugccugug ag 22
<210> 5543
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5543
auauguaaac acucaaacuc cc 22
<210> 5544
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5544
auauuuggag uguuuagaga gg 22
<210> 5545
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5545
auauuugggc ugccugugag uu 22
<210> 5546
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5546
aucaaugaac accacauaca cc 22
<210> 5547
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5547
aucaauucca aaugccccaa cu 22
<210> 5548
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5548
aucauuccca accugcuaac cc 22
<210> 5549
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5549
auccacaaac acccaaaugc ac 22
<210> 5550
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5550
auccagguau cauggaauug ga 22
<210> 5551
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5551
auccagguau cguggaauug ga 22
<210> 5552
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5552
auccagguau gguggaauug ga 22
<210> 5553
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5553
auccagugac ugccggcgca cu 22
<210> 5554
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5554
aucccaaacu ccaauuccac ca 22
<210> 5555
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5555
aucccaccaa acccugaacc uu 22
<210> 5556
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5556
auccguggaa ugacaagccc ac 22
<210> 5557
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5557
auccucucca ggaccagagg cu 22
<210> 5558
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5558
aucgccuaaa cccacacaug cc 22
<210> 5559
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5559
aucuguuggu uuagggugua ug 22
<210> 5560
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5560
aucuuagagc accccaaacc ca 22
<210> 5561
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5561
aucuucucug ggcacugcca cc 22
<210> 5562
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5562
aucuuguaaa guccaaaccu cc 22
<210> 5563
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5563
aucuuuaaac ccacacugaa aa 22
<210> 5564
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5564
augaacacca cauacacccu aa 22
<210> 5565
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5565
augaacccga aguagccaau cu 22
<210> 5566
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5566
augacaagcc cacucccgug cc 22
<210> 5567
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5567
augaccucaa uucuagaaac au 22
<210> 5568
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5568
augacuccca cucucagcca gc 22
<210> 5569
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5569
augacucuac ccacaaacag gg 22
<210> 5570
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5570
augauaccug gauuccacaa ac 22
<210> 5571
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5571
augauuauau auauuugggc ug 22
<210> 5572
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5572
augcacccug aauucuacag gg 22
<210> 5573
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5573
augccauuau cuucucuggg ca 22
<210> 5574
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5574
augccccaaa cccuaaaccu cu 22
<210> 5575
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5575
augccccaac uauacaugaa cc 22
<210> 5576
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5576
auggaauugg aguuuauaua ca 22
<210> 5577
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5577
auggcauugg caagugcgcc gg 22
<210> 5578
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5578
augggcagga cagcagccac ca 22
<210> 5579
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5579
auggguuggg uguuugugga au 22
<210> 5580
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5580
augguggaau uggaguuugg ga 22
<210> 5581
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5581
augguggcug cuguccugcc ca 22
<210> 5582
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5582
auguaaacac ucaaacuccc gg 22
<210> 5583
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5583
auguauaguu ggggcauuug ga 22
<210> 5584
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5584
auguauauaa acuccaauuc ca 22
<210> 5585
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5585
augucugcuu ccaccccaga ac 22
<210> 5586
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5586
augugagacg ccaguccuca cu 22
<210> 5587
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5587
auguggguuu ggguagguag ag 22
<210> 5588
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5588
augugguguu cauugauggu gc 22
<210> 5589
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5589
augugguuga gacgguggca gu 22
<210> 5590
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5590
auguguggcc cccucguugc cc 22
<210> 5591
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5591
augugugggu uuaggcgauu gu 22
<210> 5592
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5592
auguuucuag aauugagguc au 22
<210> 5593
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5593
auuaggacug ggguguugga gg 22
<210> 5594
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5594
auuauauaua uuugggcugc cu 22
<210> 5595
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5595
auuaucuucu cugggcacug cc 22
<210> 5596
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5596
auucaggggu uagcagguug gg 22
<210> 5597
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5597
auucagggug cauuugggug uu 22
<210> 5598
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5598
auuccaaaug ccccaacuau ac 22
<210> 5599
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5599
auuccacaaa cacccaaccc au 22
<210> 5600
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5600
auuccaccau accuggauuc ca 22
<210> 5601
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5601
auuccacgau accuggauuc ca 22
<210> 5602
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5602
auuccacgga ugugagacgc ca 22
<210> 5603
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5603
auuccaugau accuggauuc ca 22
<210> 5604
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5604
auucccaacc ugcuaacccc ug 22
<210> 5605
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5605
auucuacagg gaccuggacc cc 22
<210> 5606
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5606
auucuagaaa caucccaaac uc 22
<210> 5607
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5607
auugagguca ucuguugguu ua 22
<210> 5608
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5608
auugauugua uuuauuagga cu 22
<210> 5609
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5609
auugcaaguc cccaagcugc aa 22
<210> 5610
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5610
auuggaguuu gggauguuuc ua 22
<210> 5611
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5611
auuggcaagu gcgccggcag uc 22
<210> 5612
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5612
auuggcuacu ucggguucau gu 22
<210> 5613
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5613
auuguauuua uuaggacugg gg 22
<210> 5614
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5614
auuguggguc uggaagucca ga 22
<210> 5615
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5615
auuuauuagg acuggggugu ug 22
<210> 5616
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5616
auuugagguu uagagguuuu gg 22
<210> 5617
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5617
auuuggagug uuuagagagg ua 22
<210> 5618
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5618
auuugggagu uugcagcuug gg 22
<210> 5619
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5619
auuugggcug ccugagaguu ug 22
<210> 5620
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5620
auuugggggu ccaggucccu gu 22
<210> 5621
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5621
auuugggugu uuguggauuc ag 22
<210> 5622
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5622
auuuucagug uggguuuaaa ga 22
<210> 5623
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5623
caaaaccucu aaaccucaaa uc 22
<210> 5624
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5624
caaacaccca aaugcacccu ga 22
<210> 5625
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5625
caaacaccca acccauaaac ac 22
<210> 5626
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5626
caaacagggc ugguucuggg gu 22
<210> 5627
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5627
caaacccaca uacgccaaaa cc 22
<210> 5628
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5628
caaacccagc cuaaaccucc aa 22
<210> 5629
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5629
caaacccuaa accucuaccu cu 22
<210> 5630
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5630
caaacccuga accuuccaac ca 22
<210> 5631
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5631
caaacucaca ggcagcccaa au 22
<210> 5632
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5632
caaacuccaa uuccaccaua cc 22
<210> 5633
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5633
caaacuccca aaucuuguaa ag 22
<210> 5634
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5634
caaacucccg gacacccuca ac 22
<210> 5635
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5635
caaacucuca ggcagcccaa au 22
<210> 5636
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5636
caaaggccag gcccagcugg cu 22
<210> 5637
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5637
caaauauaua uaaucauucc ca 22
<210> 5638
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5638
caaauaugua aacacucaaa cu 22
<210> 5639
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5639
caaaucuuag agcaccccaa ac 22
<210> 5640
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5640
caaaucuugu aaaguccaaa cc 22
<210> 5641
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5641
caaaugcacc cugaauucua ca 22
<210> 5642
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5642
caaaugcccc aacuauacau ga 22
<210> 5643
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5643
caaauguaua uaaacuccaa uu 22
<210> 5644
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5644
caaaugucug cuuccacccc ag 22
<210> 5645
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5645
caacacccca guccuaauaa au 22
<210> 5646
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5646
caacagauga ccucaauucu ag 22
<210> 5647
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5647
caaccacaug ggcaggacag ca 22
<210> 5648
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5648
caaccagcgu cagcaacucc uc 22
<210> 5649
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5649
caacccauaa acacccaaac uc 22
<210> 5650
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5650
caaccgcacc aucaaugaac ac 22
<210> 5651
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5651
caaccugcua accccugaau cc 22
<210> 5652
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5652
caacgagggg gccacacauc cc 22
<210> 5653
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5653
caacuauaca ugaacccgaa gu 22
<210> 5654
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5654
caacuccucc aagucucugg ac 22
<210> 5655
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5655
caacucuacc uacccaaacc ca 22
<210> 5656
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5656
caagauuugg gaguuugcag cu 22
<210> 5657
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5657
caagcccacu cccgugcccc ac 22
<210> 5658
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5658
caagcugcaa acucccaaau cu 22
<210> 5659
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5659
caagucccca agcugcaaac uc 22
<210> 5660
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5660
caagucucug gacuuccaga cc 22
<210> 5661
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5661
caagugcgcc ggcagucacu gg 22
<210> 5662
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5662
caaucaauuc caaaugcccc aa 22
<210> 5663
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5663
caaucgccua aacccacaca ug 22
<210> 5664
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5664
caaucuuuaa acccacacug aa 22
<210> 5665
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5665
caaugaacac cacauacacc cu 22
<210> 5666
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5666
caaugccauu aucuucucug gg 22
<210> 5667
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5667
caauuccaaa ugccccaacu au 22
<210> 5668
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5668
caauuccacc auaccuggau uc 22
<210> 5669
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5669
caauuccacg auaccuggau uc 22
<210> 5670
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5670
caauuccaug auaccuggau uc 22
<210> 5671
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5671
caauucuaga aacaucccaa ac 22
<210> 5672
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5672
caauuuucag uguggguuua aa 22
<210> 5673
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5673
cacaaacacc caaaugcacc cu 22
<210> 5674
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5674
cacaaacacc caacccauaa ac 22
<210> 5675
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5675
cacaaacagg gcugguucug gg 22
<210> 5676
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5676
cacaaucgcc uaaacccaca ca 22
<210> 5677
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5677
cacacagccu gccaggcgcu ga 22
<210> 5678
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5678
cacacauccc accaaacccu ga 22
<210> 5679
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5679
cacacaugcc ccaaacccua aa 22
<210> 5680
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5680
cacacugaaa auugcaaguc cc 22
<210> 5681
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5681
cacagccugc caggcgcuga cu 22
<210> 5682
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5682
cacaggcagc ccaaauauau au 22
<210> 5683
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5683
cacaggcagc ccaaauguau au 22
<210> 5684
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5684
cacauacacc cuaaaccaac ag 22
<210> 5685
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5685
cacauacgcc aaaaccucua aa 22
<210> 5686
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5686
cacaucccac caaacccuga ac 22
<210> 5687
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5687
cacauccgug gaaugacaag cc 22
<210> 5688
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5688
cacaugcccc aaacccuaaa cc 22
<210> 5689
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5689
cacaugggca ggacagcagc ca 22
<210> 5690
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5690
caccaaaccc ugaaccuucc aa 22
<210> 5691
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5691
caccacauac acccuaaacc aa 22
<210> 5692
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5692
caccauaccu ggauuccaca aa 22
<210> 5693
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5693
caccaucaau gaacaccaca ua 22
<210> 5694
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5694
caccaugacu cccacucuca gc 22
<210> 5695
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5695
cacccaaacu cacaggcagc cc 22
<210> 5696
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5696
cacccaaacu cucaggcagc cc 22
<210> 5697
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5697
cacccaaaug cacccugaau uc 22
<210> 5698
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5698
cacccaaccc auaaacaccc aa 22
<210> 5699
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5699
caccccaaac ccagccuaaa cc 22
<210> 5700
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5700
caccccagaa ccagcccugu uu 22
<210> 5701
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5701
caccccaguc cuaauaaaua ca 22
<210> 5702
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5702
cacccuaaac caacagauga cc 22
<210> 5703
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5703
cacccucaac ucuaccuacc ca 22
<210> 5704
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5704
cacccugaau ucuacaggga cc 22
<210> 5705
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5705
caccgucuca accacauggg ca 22
<210> 5706
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5706
cacgauaccu ggauuccaca aa 22
<210> 5707
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5707
cacggaugug agacgccagu cc 22
<210> 5708
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5708
cacgggagug ggcuugucau uc 22
<210> 5709
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5709
cacucaaacu cccggacacc cu 22
<210> 5710
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5710
cacuccaaau auguaaacac uc 22
<210> 5711
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5711
cacucucagc cagcugggcc ug 22
<210> 5712
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5712
cacugaaaau ugcaaguccc ca 22
<210> 5713
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5713
cacugccacc gucucaacca ca 22
<210> 5714
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5714
cacuggaguc agcgccuggc ag 22
<210> 5715
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5715
cacuggaucc ucuccaggac ca 22
<210> 5716
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5716
cacuugccaa ugccauuauc uu 22
<210> 5717
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5717
cagaaccagc ccuguuugug gg 22
<210> 5718
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5718
cagacauuug gggguccagg uc 22
<210> 5719
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5719
cagacccaca aucgccuaaa cc 22
<210> 5720
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5720
cagagaagau aauggcauug gc 22
<210> 5721
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5721
cagagacuug gaggaguugc ug 22
<210> 5722
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5722
cagaggcugg ggcacacagc cu 22
<210> 5723
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5723
cagaugaccu caauucuaga aa 22
<210> 5724
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5724
cagcaacucc uccaagucuc ug 22
<210> 5725
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5725
cagcagccac caugacuccc ac 22
<210> 5726
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5726
cagccaccau gacucccacu cu 22
<210> 5727
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5727
cagccagcug ggccuggccu uu 22
<210> 5728
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5728
cagcccaaau auauauaauc au 22
<210> 5729
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5729
cagcccuguu uguggguaga gu 22
<210> 5730
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5730
cagccuaaac cuccaacacc cc 22
<210> 5731
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5731
cagccucugg uccuggagag ga 22
<210> 5732
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5732
cagccugcca ggcgcugacu cc 22
<210> 5733
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5733
cagcgccugg caggcugugu gc 22
<210> 5734
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5734
cagcgucagc aacuccucca ag 22
<210> 5735
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5735
cagcuggcug agagugggag uc 22
<210> 5736
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5736
cagcugggcc uggccuuuga aa 22
<210> 5737
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5737
cagcuugggg acuugcaauu uu 22
<210> 5738
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5738
caggacagca gccaccauga cu 22
<210> 5739
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5739
caggaccaga ggcuggggca ca 22
<210> 5740
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5740
caggcagccc aaauauauau aa 22
<210> 5741
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5741
caggcccagc uggcugagag ug 22
<210> 5742
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5742
caggcgcuga cuccagugag ga 22
<210> 5743
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5743
caggcugugu gccccagccu cu 22
<210> 5744
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5744
caggcuuuca aaggccaggc cc 22
<210> 5745
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5745
cagggaccug gacccccaaa ug 22
<210> 5746
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5746
cagggcuggu ucuggggugg aa 22
<210> 5747
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5747
cagggguuag cagguuggga au 22
<210> 5748
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5748
cagggugcau uuggguguuu gu 22
<210> 5749
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5749
caggguuugg ugggaugugu gg 22
<210> 5750
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5750
cagguaucau ggaauuggag uu 22
<210> 5751
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5751
cagguaucgu ggaauuggag uu 22
<210> 5752
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5752
cagguauggu ggaauuggag uu 22
<210> 5753
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5753
caggucccug uagaauucag gg 22
<210> 5754
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5754
cagguuggga augauuauau au 22
<210> 5755
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5755
cagucacugg auccucucca gg 22
<210> 5756
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5756
caguccucac uggagucagc gc 22
<210> 5757
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5757
cagugacugc cggcgcacuu gc 22
<210> 5758
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5758
cagugaggac uggcgucuca ca 22
<210> 5759
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5759
cagugcccag agaagauaau gg 22
<210> 5760
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5760
cagugugggu uuaaagauug gc 22
<210> 5761
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5761
cauaaacacc caaacucuca gg 22
<210> 5762
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5762
cauacacccu aaaccaacag au 22
<210> 5763
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5763
cauaccugga uuccacaaac ac 22
<210> 5764
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5764
cauacgccaa aaccucuaaa cc 22
<210> 5765
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5765
cauauuugga guguuuagag ag 22
<210> 5766
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5766
caucaaugaa caccacauac ac 22
<210> 5767
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5767
caucccaaac uccaauucca cc 22
<210> 5768
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5768
caucccacca aacccugaac cu 22
<210> 5769
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5769
cauccgugga augacaagcc ca 22
<210> 5770
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5770
caucuguugg uuuagggugu au 22
<210> 5771
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5771
caugaacccg aaguagccaa uc 22
<210> 5772
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5772
caugacuccc acucucagcc ag 22
<210> 5773
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5773
caugauaccu ggauuccaca aa 22
<210> 5774
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5774
caugccccaa acccuaaacc uc 22
<210> 5775
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5775
cauggaauug gaguuuauau ac 22
<210> 5776
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5776
caugggcagg acagcagcca cc 22
<210> 5777
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5777
caugguggcu gcuguccugc cc 22
<210> 5778
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5778
cauguauagu uggggcauuu gg 22
<210> 5779
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5779
caugugguug agacgguggc ag 22
<210> 5780
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5780
cauguguggg uuuaggcgau ug 22
<210> 5781
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5781
cauuaucuuc ucugggcacu gc 22
<210> 5782
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5782
cauuccacgg augugagacg cc 22
<210> 5783
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5783
cauucccaac cugcuaaccc cu 22
<210> 5784
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5784
cauuggcaag ugcgccggca gu 22
<210> 5785
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5785
cauuugggcu gccugagagu uu 22
<210> 5786
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5786
cauuugggcu gccugugagu uu 22
<210> 5787
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5787
cauuuggggg uccagguccc ug 22
<210> 5788
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5788
cauuugggug uuuguggauu ca 22
<210> 5789
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5789
ccaaaaccuc uaaaccucaa au 22
<210> 5790
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5790
ccaaacccac auacgccaaa ac 22
<210> 5791
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5791
ccaaacccag ccuaaaccuc ca 22
<210> 5792
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5792
ccaaacccua aaccucuacc uc 22
<210> 5793
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5793
ccaaacccug aaccuuccaa cc 22
<210> 5794
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5794
ccaaacucac aggcagccca aa 22
<210> 5795
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5795
ccaaacucca auuccaccau ac 22
<210> 5796
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5796
ccaaacucuc aggcagccca aa 22
<210> 5797
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5797
ccaaauauau auaaucauuc cc 22
<210> 5798
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5798
ccaaauaugu aaacacucaa ac 22
<210> 5799
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5799
ccaaaucuug uaaaguccaa ac 22
<210> 5800
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5800
ccaaaugcac ccugaauucu ac 22
<210> 5801
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5801
ccaaaugccc caacuauaca ug 22
<210> 5802
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5802
ccaaauguau auaaacucca au 22
<210> 5803
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5803
ccaaaugucu gcuuccaccc ca 22
<210> 5804
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5804
ccaacacccc aguccuaaua aa 22
<210> 5805
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5805
ccaacagaug accucaauuc ua 22
<210> 5806
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5806
ccaaccagcg ucagcaacuc cu 22
<210> 5807
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5807
ccaacccaua aacacccaaa cu 22
<210> 5808
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5808
ccaaccgcac caucaaugaa ca 22
<210> 5809
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5809
ccaaccugcu aaccccugaa uc 22
<210> 5810
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5810
ccaacuauac augaacccga ag 22
<210> 5811
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5811
ccaagcugca aacucccaaa uc 22
<210> 5812
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5812
ccaagucucu ggacuuccag ac 22
<210> 5813
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5813
ccaaucuuua aacccacacu ga 22
<210> 5814
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5814
ccaaugccau uaucuucucu gg 22
<210> 5815
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5815
ccaauuccac cauaccugga uu 22
<210> 5816
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5816
ccaauuccac gauaccugga uu 22
<210> 5817
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5817
ccaauuccau gauaccugga uu 22
<210> 5818
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5818
ccacaaacac ccaaaugcac cc 22
<210> 5819
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5819
ccacaaacac ccaacccaua aa 22
<210> 5820
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5820
ccacaaacag ggcugguucu gg 22
<210> 5821
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5821
ccacaaucgc cuaaacccac ac 22
<210> 5822
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5822
ccacacaucc caccaaaccc ug 22
<210> 5823
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5823
ccacacaugc cccaaacccu aa 22
<210> 5824
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5824
ccacacugaa aauugcaagu cc 22
<210> 5825
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5825
ccacauacac ccuaaaccaa ca 22
<210> 5826
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5826
ccacauacgc caaaaccucu aa 22
<210> 5827
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5827
ccacaugggc aggacagcag cc 22
<210> 5828
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5828
ccaccaaacc cugaaccuuc ca 22
<210> 5829
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5829
ccaccauacc uggauuccac aa 22
<210> 5830
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5830
ccaccaugac ucccacucuc ag 22
<210> 5831
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5831
ccaccccaga accagcccug uu 22
<210> 5832
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5832
ccaccgucuc aaccacaugg gc 22
<210> 5833
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5833
ccacgauacc uggauuccac aa 22
<210> 5834
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5834
ccacggaugu gagacgccag uc 22
<210> 5835
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5835
ccacucucag ccagcugggc cu 22
<210> 5836
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5836
ccagaaccag cccuguuugu gg 22
<210> 5837
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5837
ccagacccac aaucgccuaa ac 22
<210> 5838
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5838
ccagagaaga uaauggcauu gg 22
<210> 5839
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5839
ccagagacuu ggaggaguug cu 22
<210> 5840
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5840
ccagaggcug gggcacacag cc 22
<210> 5841
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5841
ccagcccugu uuguggguag ag 22
<210> 5842
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5842
ccagccuaaa ccuccaacac cc 22
<210> 5843
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5843
ccagccucug guccuggaga gg 22
<210> 5844
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5844
ccagcgucag caacuccucc aa 22
<210> 5845
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5845
ccagcuggcu gagaguggga gu 22
<210> 5846
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5846
ccagcugggc cuggccuuug aa 22
<210> 5847
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5847
ccaggaccag aggcuggggc ac 22
<210> 5848
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5848
ccaggcccag cuggcugaga gu 22
<210> 5849
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5849
ccaggcgcug acuccaguga gg 22
<210> 5850
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5850
ccaggcuuuc aaaggccagg cc 22
<210> 5851
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5851
ccagguauca uggaauugga gu 22
<210> 5852
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5852
ccagguaucg uggaauugga gu 22
<210> 5853
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5853
ccagguaugg uggaauugga gu 22
<210> 5854
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5854
ccaggucccu guagaauuca gg 22
<210> 5855
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5855
ccaguccuaa uaaauacaau ca 22
<210> 5856
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5856
ccaguccuca cuggagucag cg 22
<210> 5857
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5857
ccagugacug ccggcgcacu ug 22
<210> 5858
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5858
ccagugagga cuggcgucuc ac 22
<210> 5859
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5859
ccauaaacac ccaaacucuc ag 22
<210> 5860
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5860
ccauaccugg auuccacaaa ca 22
<210> 5861
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5861
ccaucaauga acaccacaua ca 22
<210> 5862
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5862
ccaugacucc cacucucagc ca 22
<210> 5863
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5863
ccaugauacc uggauuccac aa 22
<210> 5864
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5864
ccaugugguu gagacggugg ca 22
<210> 5865
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5865
ccauuaucuu cucugggcac ug 22
<210> 5866
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5866
cccaaaccca cauacgccaa aa 22
<210> 5867
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5867
cccaaaccca gccuaaaccu cc 22
<210> 5868
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5868
cccaaacccu aaaccucuac cu 22
<210> 5869
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5869
cccaaacuca caggcagccc aa 22
<210> 5870
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5870
cccaaacucc aauuccacca ua 22
<210> 5871
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5871
cccaaacucu caggcagccc aa 22
<210> 5872
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5872
cccaaauaua uauaaucauu cc 22
<210> 5873
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5873
cccaaaucuu guaaagucca aa 22
<210> 5874
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5874
cccaaaugca cccugaauuc ua 22
<210> 5875
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5875
cccaaaugua uauaaacucc aa 22
<210> 5876
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5876
cccaaauguc ugcuuccacc cc 22
<210> 5877
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5877
cccaacccau aaacacccaa ac 22
<210> 5878
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5878
cccaaccgca ccaucaauga ac 22
<210> 5879
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5879
cccaaccugc uaaccccuga au 22
<210> 5880
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5880
cccaacuaua caugaacccg aa 22
<210> 5881
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5881
cccaagcugc aaacucccaa au 22
<210> 5882
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5882
cccacaaaca gggcugguuc ug 22
<210> 5883
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5883
cccacaaucg ccuaaaccca ca 22
<210> 5884
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5884
cccacacaug ccccaaaccc ua 22
<210> 5885
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5885
cccacacuga aaauugcaag uc 22
<210> 5886
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5886
cccacauacg ccaaaaccuc ua 22
<210> 5887
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5887
cccaccaaac ccugaaccuu cc 22
<210> 5888
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5888
cccacucuca gccagcuggg cc 22
<210> 5889
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5889
cccagaacca gcccuguuug ug 22
<210> 5890
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5890
cccagagaag auaauggcau ug 22
<210> 5891
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5891
cccagccuaa accuccaaca cc 22
<210> 5892
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5892
cccagccucu gguccuggag ag 22
<210> 5893
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5893
cccagcuggc ugagaguggg ag 22
<210> 5894
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5894
cccaggcuuu caaaggccag gc 22
<210> 5895
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5895
cccaguccua auaaauacaa uc 22
<210> 5896
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5896
cccauaaaca cccaaacucu ca 22
<210> 5897
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5897
cccauguggu ugagacggug gc 22
<210> 5898
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5898
ccccaaaccc agccuaaacc uc 22
<210> 5899
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5899
ccccaaaccc uaaaccucua cc 22
<210> 5900
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5900
ccccaaaugu cugcuuccac cc 22
<210> 5901
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5901
ccccaaccgc accaucaaug aa 22
<210> 5902
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5902
ccccaacuau acaugaaccc ga 22
<210> 5903
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5903
ccccaagcug caaacuccca aa 22
<210> 5904
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5904
ccccagaacc agcccuguuu gu 22
<210> 5905
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5905
ccccagccuc ugguccugga ga 22
<210> 5906
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5906
ccccaguccu aauaaauaca au 22
<210> 5907
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5907
cccccaaaug ucugcuucca cc 22
<210> 5908
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5908
cccccaaccg caccaucaau ga 22
<210> 5909
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5909
cccccucguu gcccaggcuu uc 22
<210> 5910
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5910
ccccucguug cccaggcuuu ca 22
<210> 5911
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5911
ccccugaauc cacaaacacc ca 22
<210> 5912
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5912
cccgaaguag ccaaucuuua aa 22
<210> 5913
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5913
cccggacacc cucaacucua cc 22
<210> 5914
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5914
cccuaaacca acagaugacc uc 22
<210> 5915
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5915
cccuaaaccu cuaccucucu aa 22
<210> 5916
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5916
cccucaacuc uaccuaccca aa 22
<210> 5917
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5917
cccucguugc ccaggcuuuc aa 22
<210> 5918
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5918
cccugaaccu uccaaccagc gu 22
<210> 5919
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5919
cccugaaucc acaaacaccc aa 22
<210> 5920
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5920
cccugaauuc uacagggacc ug 22
<210> 5921
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5921
cccuguagaa uucagggugc au 22
<210> 5922
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5922
cccuguuugu ggguagaguc au 22
<210> 5923
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5923
ccgaaguagc caaucuuuaa ac 22
<210> 5924
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5924
ccgcaccauc aaugaacacc ac 22
<210> 5925
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5925
ccggacaccc ucaacucuac cu 22
<210> 5926
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5926
ccggcaguca cuggauccuc uc 22
<210> 5927
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5927
ccggcgcacu ugccaaugcc au 22
<210> 5928
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5928
ccgggaguuu gaguguuuac au 22
<210> 5929
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5929
ccgucucaac cacaugggca gg 22
<210> 5930
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5930
ccguggaaug acaagcccac uc 22
<210> 5931
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5931
ccuaaaccaa cagaugaccu ca 22
<210> 5932
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5932
ccuaaaccca cacaugcccc aa 22
<210> 5933
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5933
ccuaaaccuc caacacccca gu 22
<210> 5934
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5934
ccuaaaccuc uaccucucua aa 22
<210> 5935
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5935
ccuacccaaa cccacauacg cc 22
<210> 5936
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5936
ccucaaaucu uagagcaccc ca 22
<210> 5937
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5937
ccucaacucu accuacccaa ac 22
<210> 5938
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5938
ccucaauucu agaaacaucc ca 22
<210> 5939
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5939
ccucacugga gucagcgccu gg 22
<210> 5940
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5940
ccuccaacac cccaguccua au 22
<210> 5941
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5941
ccuccaaguc ucuggacuuc ca 22
<210> 5942
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5942
ccucguugcc caggcuuuca aa 22
<210> 5943
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5943
ccucuaaacc ucaaaucuua ga 22
<210> 5944
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5944
ccucuaccuc ucuaaacacu cc 22
<210> 5945
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5945
ccucuccagg accagaggcu gg 22
<210> 5946
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5946
ccucucuaaa cacuccaaau au 22
<210> 5947
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5947
ccucuggucc uggagaggau cc 22
<210> 5948
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5948
ccugaaccuu ccaaccagcg uc 22
<210> 5949
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5949
ccugaaucca caaacaccca aa 22
<210> 5950
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5950
ccugaauucu acagggaccu gg 22
<210> 5951
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5951
ccugagaguu uggguguuua ug 22
<210> 5952
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5952
ccugccaggc gcugacucca gu 22
<210> 5953
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5953
ccugcccaug ugguugagac gg 22
<210> 5954
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5954
ccugcuaacc ccugaaucca ca 22
<210> 5955
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5955
ccuggacccc caaaugucug cu 22
<210> 5956
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5956
ccuggagagg auccagugac ug 22
<210> 5957
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5957
ccuggauucc acaaacaccc aa 22
<210> 5958
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5958
ccuggcaggc ugugugcccc ag 22
<210> 5959
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5959
ccuggccuuu gaaagccugg gc 22
<210> 5960
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5960
ccugggcaac gagggggcca ca 22
<210> 5961
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5961
ccuguagaau ucagggugca uu 22
<210> 5962
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5962
ccuguuugug gguagaguca ua 22
<210> 5963
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5963
ccuuccaacc agcgucagca ac 22
<210> 5964
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5964
ccuuugaaag ccugggcaac ga 22
<210> 5965
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5965
cgaaguagcc aaucuuuaaa cc 22
<210> 5966
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5966
cgagggggcc acacauccca cc 22
<210> 5967
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5967
cgauaccugg auuccacaaa ca 22
<210> 5968
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5968
cgauuguggg ucuggaaguc ca 22
<210> 5969
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5969
cgcaccauca augaacacca ca 22
<210> 5970
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5970
cgcacuugcc aaugccauua uc 22
<210> 5971
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5971
cgccaaaacc ucuaaaccuc aa 22
<210> 5972
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5972
cgccaguccu cacuggaguc ag 22
<210> 5973
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5973
cgccggcagu cacuggaucc uc 22
<210> 5974
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5974
cgccuaaacc cacacaugcc cc 22
<210> 5975
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5975
cgccuggcag gcugugugcc cc 22
<210> 5976
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5976
cgcugacucc agugaggacu gg 22
<210> 5977
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5977
cgcugguugg aagguucagg gu 22
<210> 5978
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5978
cggacacccu caacucuacc ua 22
<210> 5979
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5979
cggagguuug gacuuuacaa ga 22
<210> 5980
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5980
cggagugggg cacgggagug gg 22
<210> 5981
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5981
cggaugugag acgccagucc uc 22
<210> 5982
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5982
cggcagucac uggauccucu cc 22
<210> 5983
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5983
cggcgcacuu gccaaugcca uu 22
<210> 5984
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5984
cgggaguggg cuugucauuc ca 22
<210> 5985
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5985
cgggaguuug aguguuuaca ua 22
<210> 5986
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5986
cggguucaug uauaguuggg gc 22
<210> 5987
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5987
cgguggcagu gcccagagaa ga 22
<210> 5988
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5988
cguauguggg uuuggguagg ua 22
<210> 5989
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5989
cgucagcaac uccuccaagu cu 22
<210> 5990
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5990
cgucucaacc acaugggcag ga 22
<210> 5991
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5991
cguggaauga caagcccacu cc 22
<210> 5992
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5992
cguggaauug gaguuuauau ac 22
<210> 5993
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5993
cguugcccag gcuuucaaag gc 22
<210> 5994
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5994
cuaaacacuc caaauaugua aa 22
<210> 5995
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5995
cuaaaccaac agaugaccuc aa 22
<210> 5996
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5996
cuaaacccac acaugcccca aa 22
<210> 5997
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5997
cuaaaccuca aaucuuagag ca 22
<210> 5998
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5998
cuaaaccucc aacaccccag uc 22
<210> 5999
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 5999
cuaaaccucu accucucuaa ac 22
<210> 6000
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6000
cuaaccccug aauccacaaa ca 22
<210> 6001
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6001
cuaagauuug agguuuagag gu 22
<210> 6002
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6002
cuacagggac cuggaccccc aa 22
<210> 6003
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6003
cuacccaaac ccacauacgc ca 22
<210> 6004
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6004
cuacccacaa acagggcugg uu 22
<210> 6005
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6005
cuaccuaccc aaacccacau ac 22
<210> 6006
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6006
cuaccucucu aaacacucca aa 22
<210> 6007
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6007
cuacuucggg uucauguaua gu 22
<210> 6008
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6008
cuagaaacau cccaaacucc aa 22
<210> 6009
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6009
cuagaauuga ggucaucugu ug 22
<210> 6010
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6010
cuauacauga acccgaagua gc 22
<210> 6011
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6011
cucaaacucc cggacacccu ca 22
<210> 6012
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6012
cucaaaucuu agagcacccc aa 22
<210> 6013
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6013
cucaaccaca ugggcaggac ag 22
<210> 6014
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6014
cucaacucua ccuacccaaa cc 22
<210> 6015
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6015
cucaauucua gaaacauccc aa 22
<210> 6016
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6016
cucacaggca gcccaaauau au 22
<210> 6017
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6017
cucacaggca gcccaaaugu au 22
<210> 6018
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6018
cucacauccg uggaaugaca ag 22
<210> 6019
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6019
cucacuggag ucagcgccug gc 22
<210> 6020
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6020
cucagccagc ugggccuggc cu 22
<210> 6021
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6021
cucaggcagc ccaaauguau au 22
<210> 6022
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6022
cuccaaauau guaaacacuc aa 22
<210> 6023
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6023
cuccaacacc ccaguccuaa ua 22
<210> 6024
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6024
cuccaagucu cuggacuucc ag 22
<210> 6025
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6025
cuccaauucc accauaccug ga 22
<210> 6026
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6026
cuccaauucc acgauaccug ga 22
<210> 6027
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6027
cuccaauucc augauaccug ga 22
<210> 6028
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6028
cuccaggacc agaggcuggg gc 22
<210> 6029
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6029
cuccagugag gacuggcguc uc 22
<210> 6030
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6030
cucccaaauc uuguaaaguc ca 22
<210> 6031
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6031
cucccacucu cagccagcug gg 22
<210> 6032
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6032
cucccggaca cccucaacuc ua 22
<210> 6033
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6033
cuccuccaag ucucuggacu uc 22
<210> 6034
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6034
cucggagguu uggacuuuac aa 22
<210> 6035
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6035
cucguugccc aggcuuucaa ag 22
<210> 6036
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6036
cucuaaacac uccaaauaug ua 22
<210> 6037
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6037
cucuaaaccu caaaucuuag ag 22
<210> 6038
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6038
cucuaagauu ugagguuuag ag 22
<210> 6039
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6039
cucuacccac aaacagggcu gg 22
<210> 6040
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6040
cucuaccuac ccaaacccac au 22
<210> 6041
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6041
cucuaccucu cuaaacacuc ca 22
<210> 6042
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6042
cucucagcca gcugggccug gc 22
<210> 6043
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6043
cucucaggca gcccaaaugu au 22
<210> 6044
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6044
cucuccagga ccagaggcug gg 22
<210> 6045
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6045
cucucuaaac acuccaaaua ug 22
<210> 6046
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6046
cucuggacuu ccagacccac aa 22
<210> 6047
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6047
cucugggcac ugccaccguc uc 22
<210> 6048
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6048
cucugguccu ggagaggauc ca 22
<210> 6049
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6049
cugaaaauug caagucccca ag 22
<210> 6050
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6050
cugaaccuuc caaccagcgu ca 22
<210> 6051
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6051
cugaauccac aaacacccaa au 22
<210> 6052
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6052
cugaauucua cagggaccug ga 22
<210> 6053
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6053
cugacgcugg uuggaagguu ca 22
<210> 6054
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6054
cugacuccag ugaggacugg cg 22
<210> 6055
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6055
cugagagugg gagucauggu gg 22
<210> 6056
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6056
cugagaguuu ggguguuuau gg 22
<210> 6057
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6057
cugcaaacuc ccaaaucuug ua 22
<210> 6058
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6058
cugccaccgu cucaaccaca ug 22
<210> 6059
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6059
cugccaggcg cugacuccag ug 22
<210> 6060
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6060
cugcccaugu gguugagacg gu 22
<210> 6061
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6061
cugccggcgc acuugccaau gc 22
<210> 6062
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6062
cugccugaga guuugggugu uu 22
<210> 6063
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6063
cugcuaaccc cugaauccac aa 22
<210> 6064
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6064
cugcuguccu gcccaugugg uu 22
<210> 6065
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6065
cugcuuccac cccagaacca gc 22
<210> 6066
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6066
cuggaagucc agagacuugg ag 22
<210> 6067
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6067
cuggaccccc aaaugucugc uu 22
<210> 6068
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6068
cuggacuucc agacccacaa uc 22
<210> 6069
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6069
cuggagagga uccagugacu gc 22
<210> 6070
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6070
cuggagucag cgccuggcag gc 22
<210> 6071
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6071
cuggauccuc uccaggacca ga 22
<210> 6072
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6072
cuggauucca caaacaccca ac 22
<210> 6073
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6073
cuggcaggcu gugugcccca gc 22
<210> 6074
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6074
cuggccuuug aaagccuggg ca 22
<210> 6075
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6075
cuggcgucuc acauccgugg aa 22
<210> 6076
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6076
cuggcugaga gugggaguca ug 22
<210> 6077
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6077
cugggcaacg agggggccac ac 22
<210> 6078
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6078
cugggcacug ccaccgucuc aa 22
<210> 6079
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6079
cugggccugg ccuuugaaag cc 22
<210> 6080
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6080
cuggggcaca cagccugcca gg 22
<210> 6081
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6081
cuggggugga agcagacauu ug 22
<210> 6082
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6082
cugggguguu ggagguuuag gc 22
<210> 6083
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6083
cuggguuugg ggugcucuaa ga 22
<210> 6084
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6084
cugguccugg agaggaucca gu 22
<210> 6085
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6085
cugguucugg gguggaagca ga 22
<210> 6086
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6086
cugguuggaa gguucagggu uu 22
<210> 6087
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6087
cuguagaauu cagggugcau uu 22
<210> 6088
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6088
cuguccugcc caugugguug ag 22
<210> 6089
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6089
cugucggagu ggggcacggg ag 22
<210> 6090
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6090
cugugugccc cagccucugg uc 22
<210> 6091
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6091
cuguugguuu aggguguaug ug 22
<210> 6092
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6092
cuguuugugg guagagucau aa 22
<210> 6093
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6093
cuuagagcac cccaaaccca gc 22
<210> 6094
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6094
cuuccaacca gcgucagcaa cu 22
<210> 6095
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6095
cuuccacccc agaaccagcc cu 22
<210> 6096
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6096
cuuccagacc cacaaucgcc ua 22
<210> 6097
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6097
cuucggguuc auguauaguu gg 22
<210> 6098
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6098
cuucucuggg cacugccacc gu 22
<210> 6099
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6099
cuugcaauuu ucaguguggg uu 22
<210> 6100
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6100
cuugccaaug ccauuaucuu cu 22
<210> 6101
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6101
cuuggaggag uugcugacgc ug 22
<210> 6102
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6102
cuuggggacu ugcaauuuuc ag 22
<210> 6103
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6103
cuuguaaagu ccaaaccucc ga 22
<210> 6104
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6104
cuugucauuc cacggaugug ag 22
<210> 6105
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6105
cuuuaaaccc acacugaaaa uu 22
<210> 6106
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6106
cuuuacaaga uuugggaguu ug 22
<210> 6107
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6107
cuuucaaagg ccaggcccag cu 22
<210> 6108
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6108
cuuugaaagc cugggcaacg ag 22
<210> 6109
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6109
gaaaauugca aguccccaag cu 22
<210> 6110
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6110
gaaacauccc aaacuccaau uc 22
<210> 6111
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6111
gaaagccugg gcaacgaggg gg 22
<210> 6112
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6112
gaacaccaca uacacccuaa ac 22
<210> 6113
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6113
gaaccagccc uguuuguggg ua 22
<210> 6114
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6114
gaacccgaag uagccaaucu uu 22
<210> 6115
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6115
gaaccuucca accagcguca gc 22
<210> 6116
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6116
gaagauaaug gcauuggcaa gu 22
<210> 6117
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6117
gaagcagaca uuuggggguc ca 22
<210> 6118
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6118
gaagguucag gguuuggugg ga 22
<210> 6119
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6119
gaaguagcca aucuuuaaac cc 22
<210> 6120
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6120
gaaguccaga gacuuggagg ag 22
<210> 6121
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6121
gaauccacaa acacccaaau gc 22
<210> 6122
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6122
gaauccaggu aucauggaau ug 22
<210> 6123
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6123
gaauccaggu aucguggaau ug 22
<210> 6124
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6124
gaauccaggu augguggaau ug 22
<210> 6125
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6125
gaaugacaag cccacucccg ug 22
<210> 6126
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6126
gaaugauuau auauauuugg gc 22
<210> 6127
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6127
gaauucaggg ugcauuuggg ug 22
<210> 6128
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6128
gaauucuaca gggaccugga cc 22
<210> 6129
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6129
gaauugaggu caucuguugg uu 22
<210> 6130
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6130
gaauugauug uauuuauuag ga 22
<210> 6131
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6131
gaauuggagu uugggauguu uc 22
<210> 6132
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6132
gacaagccca cucccgugcc cc 22
<210> 6133
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6133
gacacccuca acucuaccua cc 22
<210> 6134
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6134
gacagcagcc accaugacuc cc 22
<210> 6135
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6135
gacauuuggg gguccagguc cc 22
<210> 6136
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6136
gaccagaggc uggggcacac ag 22
<210> 6137
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6137
gacccacaau cgccuaaacc ca 22
<210> 6138
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6138
gacccccaaa ugucugcuuc ca 22
<210> 6139
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6139
gaccucaauu cuagaaacau cc 22
<210> 6140
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6140
gaccuggacc cccaaauguc ug 22
<210> 6141
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6141
gacgccaguc cucacuggag uc 22
<210> 6142
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6142
gacgcugguu ggaagguuca gg 22
<210> 6143
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6143
gacgguggca gugcccagag aa 22
<210> 6144
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6144
gacuccagug aggacuggcg uc 22
<210> 6145
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6145
gacucccacu cucagccagc ug 22
<210> 6146
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6146
gacucggagg uuuggacuuu ac 22
<210> 6147
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6147
gacucuaccc acaaacaggg cu 22
<210> 6148
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6148
gacugccggc gcacuugcca au 22
<210> 6149
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6149
gacuggcguc ucacauccgu gg 22
<210> 6150
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6150
gacuggggug uuggagguuu ag 22
<210> 6151
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6151
gacuuccaga cccacaaucg cc 22
<210> 6152
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6152
gacuugcaau uuucagugug gg 22
<210> 6153
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6153
gacuuggagg aguugcugac gc 22
<210> 6154
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6154
gacuuuacaa gauuugggag uu 22
<210> 6155
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6155
gagaagauaa uggcauuggc aa 22
<210> 6156
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6156
gagacgccag uccucacugg ag 22
<210> 6157
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6157
gagacggugg cagugcccag ag 22
<210> 6158
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6158
gagacucgga gguuuggacu uu 22
<210> 6159
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6159
gagacuugga ggaguugcug ac 22
<210> 6160
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6160
gagaggaucc agugacugcc gg 22
<210> 6161
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6161
gagagguaga gguuuagggu uu 22
<210> 6162
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6162
gagaguggga gucauggugg cu 22
<210> 6163
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6163
gagaguuugg guguuuaugg gu 22
<210> 6164
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6164
gagcacccca aacccagccu aa 22
<210> 6165
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6165
gaggacuggc gucucacauc cg 22
<210> 6166
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6166
gaggaguugc ugacgcuggu ug 22
<210> 6167
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6167
gaggauccag ugacugccgg cg 22
<210> 6168
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6168
gaggcugggg cacacagccu gc 22
<210> 6169
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6169
gagggggcca cacaucccac ca 22
<210> 6170
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6170
gagggugucc gggaguuuga gu 22
<210> 6171
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6171
gagguagagg uuuaggguuu gg 22
<210> 6172
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6172
gaggucaucu guugguuuag gg 22
<210> 6173
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6173
gagguuuaga gguuuuggcg ua 22
<210> 6174
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6174
gagguuuagg cuggguuugg gg 22
<210> 6175
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6175
gagguuuagg guuuggggca ug 22
<210> 6176
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6176
gagguuugga cuuuacaaga uu 22
<210> 6177
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6177
gagguuuugg cguauguggg uu 22
<210> 6178
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6178
gagucagcgc cuggcaggcu gu 22
<210> 6179
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6179
gagucauggu ggcugcuguc cu 22
<210> 6180
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6180
gagugggagu caugguggcu gc 22
<210> 6181
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6181
gagugggcuu gucauuccac gg 22
<210> 6182
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6182
gaguggggca cgggaguggg cu 22
<210> 6183
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6183
gagugguuau gacucuaccc ac 22
<210> 6184
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6184
gaguguuuac auauuuggag ug 22
<210> 6185
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6185
gaguguuuag agagguagag gu 22
<210> 6186
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6186
gaguugaggg uguccgggag uu 22
<210> 6187
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6187
gaguugcuga cgcugguugg aa 22
<210> 6188
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6188
gaguuuauau acauuugggc ug 22
<210> 6189
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6189
gaguuugagu guuuacauau uu 22
<210> 6190
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6190
gaguuugcag cuuggggacu ug 22
<210> 6191
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6191
gaguuuggga uguuucuaga au 22
<210> 6192
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6192
gaguuugggu guuuaugggu ug 22
<210> 6193
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6193
gauaauggca uuggcaagug cg 22
<210> 6194
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6194
gauccaguga cugccggcgc ac 22
<210> 6195
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6195
gauccucucc aggaccagag gc 22
<210> 6196
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6196
gaugaccuca auucuagaaa ca 22
<210> 6197
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6197
gaugugagac gccaguccuc ac 22
<210> 6198
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6198
gauguguggc ccccucguug cc 22
<210> 6199
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6199
gauguuucua gaauugaggu ca 22
<210> 6200
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6200
gauuauauau auuugggcug cc 22
<210> 6201
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6201
gauucagggg uuagcagguu gg 22
<210> 6202
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6202
gauuccacaa acacccaacc ca 22
<210> 6203
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6203
gauuggcuac uucggguuca ug 22
<210> 6204
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6204
gauuguauuu auuaggacug gg 22
<210> 6205
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6205
gauugugggu cuggaagucc ag 22
<210> 6206
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6206
gauuugaggu uuagagguuu ug 22
<210> 6207
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6207
gauuugggag uuugcagcuu gg 22
<210> 6208
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6208
gcaaacuccc aaaucuugua aa 22
<210> 6209
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6209
gcaacgaggg ggccacacau cc 22
<210> 6210
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6210
gcaacuccuc caagucucug ga 22
<210> 6211
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6211
gcaagucccc aagcugcaaa cu 22
<210> 6212
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6212
gcaagugcgc cggcagucac ug 22
<210> 6213
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6213
gcaauuuuca guguggguuu aa 22
<210> 6214
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6214
gcacacagcc ugccaggcgc ug 22
<210> 6215
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6215
gcaccaucaa ugaacaccac au 22
<210> 6216
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6216
gcaccccaaa cccagccuaa ac 22
<210> 6217
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6217
gcacccugaa uucuacaggg ac 22
<210> 6218
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6218
gcacgggagu gggcuuguca uu 22
<210> 6219
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6219
gcacugccac cgucucaacc ac 22
<210> 6220
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6220
gcacuugcca augccauuau cu 22
<210> 6221
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6221
gcagacauuu ggggguccag gu 22
<210> 6222
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6222
gcagccacca ugacucccac uc 22
<210> 6223
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6223
gcagcccaaa uauauauaau ca 22
<210> 6224
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6224
gcagcuuggg gacuugcaau uu 22
<210> 6225
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6225
gcaggacagc agccaccaug ac 22
<210> 6226
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6226
gcaggcugug ugccccagcc uc 22
<210> 6227
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6227
gcagguuggg aaugauuaua ua 22
<210> 6228
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6228
gcagucacug gauccucucc ag 22
<210> 6229
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6229
gcagugccca gagaagauaa ug 22
<210> 6230
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6230
gcaugugugg guuuaggcga uu 22
<210> 6231
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6231
gcauuggcaa gugcgccggc ag 22
<210> 6232
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6232
gcauuugggu guuuguggau uc 22
<210> 6233
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6233
gccaaaaccu cuaaaccuca aa 22
<210> 6234
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6234
gccaaucuuu aaacccacac ug 22
<210> 6235
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6235
gccaaugcca uuaucuucuc ug 22
<210> 6236
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6236
gccacacauc ccaccaaacc cu 22
<210> 6237
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6237
gccaccauga cucccacucu ca 22
<210> 6238
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6238
gccaccgucu caaccacaug gg 22
<210> 6239
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6239
gccagcuggg ccuggccuuu ga 22
<210> 6240
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6240
gccaggccca gcuggcugag ag 22
<210> 6241
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6241
gccaggcgcu gacuccagug ag 22
<210> 6242
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6242
gccaguccuc acuggaguca gc 22
<210> 6243
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6243
gccauuaucu ucucugggca cu 22
<210> 6244
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6244
gcccaaauau auauaaucau uc 22
<210> 6245
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6245
gcccagagaa gauaauggca uu 22
<210> 6246
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6246
gcccagcugg cugagagugg ga 22
<210> 6247
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6247
gcccaggcuu ucaaaggcca gg 22
<210> 6248
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6248
gcccaugugg uugagacggu gg 22
<210> 6249
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6249
gccccaaacc cuaaaccucu ac 22
<210> 6250
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6250
gccccaacua uacaugaacc cg 22
<210> 6251
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6251
gccccagccu cugguccugg ag 22
<210> 6252
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6252
gcccccucgu ugcccaggcu uu 22
<210> 6253
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6253
gcccuguuug uggguagagu ca 22
<210> 6254
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6254
gccggcaguc acuggauccu cu 22
<210> 6255
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6255
gccggcgcac uugccaaugc ca 22
<210> 6256
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6256
gccuaaaccc acacaugccc ca 22
<210> 6257
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6257
gccuaaaccu ccaacacccc ag 22
<210> 6258
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6258
gccucugguc cuggagagga uc 22
<210> 6259
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6259
gccugagagu uuggguguuu au 22
<210> 6260
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6260
gccugccagg cgcugacucc ag 22
<210> 6261
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6261
gccuggcagg cugugugccc ca 22
<210> 6262
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6262
gccuggccuu ugaaagccug gg 22
<210> 6263
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6263
gccugggcaa cgagggggcc ac 22
<210> 6264
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6264
gccuuugaaa gccugggcaa cg 22
<210> 6265
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6265
gcgauugugg gucuggaagu cc 22
<210> 6266
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6266
gcgcacuugc caaugccauu au 22
<210> 6267
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6267
gcgccggcag ucacuggauc cu 22
<210> 6268
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6268
gcgccuggca ggcugugugc cc 22
<210> 6269
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6269
gcgcugacuc cagugaggac ug 22
<210> 6270
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6270
gcguaugugg guuuggguag gu 22
<210> 6271
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6271
gcgucagcaa cuccuccaag uc 22
<210> 6272
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6272
gcgucucaca uccguggaau ga 22
<210> 6273
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6273
gcuaaccccu gaauccacaa ac 22
<210> 6274
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6274
gcuacuucgg guucauguau ag 22
<210> 6275
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6275
gcucuaagau uugagguuua ga 22
<210> 6276
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6276
gcugacgcug guuggaaggu uc 22
<210> 6277
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6277
gcugacucca gugaggacug gc 22
<210> 6278
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6278
gcugagagug ggagucaugg ug 22
<210> 6279
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6279
gcugcaaacu cccaaaucuu gu 22
<210> 6280
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6280
gcugccugag aguuugggug uu 22
<210> 6281
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6281
gcugcugucc ugcccaugug gu 22
<210> 6282
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6282
gcuggcugag agugggaguc au 22
<210> 6283
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6283
gcugggccug gccuuugaaa gc 22
<210> 6284
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6284
gcuggggcac acagccugcc ag 22
<210> 6285
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6285
gcuggguuug gggugcucua ag 22
<210> 6286
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6286
gcugguucug ggguggaagc ag 22
<210> 6287
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6287
gcugguugga agguucaggg uu 22
<210> 6288
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6288
gcuguccugc ccaugugguu ga 22
<210> 6289
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6289
gcugugugcc ccagccucug gu 22
<210> 6290
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6290
gcuuccaccc cagaaccagc cc 22
<210> 6291
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6291
gcuuggggac uugcaauuuu ca 22
<210> 6292
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6292
gcuugucauu ccacggaugu ga 22
<210> 6293
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6293
gcuuucaaag gccaggccca gc 22
<210> 6294
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6294
ggaagcagac auuugggggu cc 22
<210> 6295
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6295
ggaagguuca ggguuuggug gg 22
<210> 6296
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6296
ggaaguccag agacuuggag ga 22
<210> 6297
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6297
ggaauccagg uaucauggaa uu 22
<210> 6298
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6298
ggaauccagg uaucguggaa uu 22
<210> 6299
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6299
ggaauccagg uaugguggaa uu 22
<210> 6300
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6300
ggaaugacaa gcccacuccc gu 22
<210> 6301
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6301
ggaaugauua uauauauuug gg 22
<210> 6302
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6302
ggaauugauu guauuuauua gg 22
<210> 6303
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6303
ggaauuggag uuugggaugu uu 22
<210> 6304
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6304
ggacacccuc aacucuaccu ac 22
<210> 6305
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6305
ggacagcagc caccaugacu cc 22
<210> 6306
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6306
ggaccagagg cuggggcaca ca 22
<210> 6307
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6307
ggacccccaa augucugcuu cc 22
<210> 6308
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6308
ggaccuggac ccccaaaugu cu 22
<210> 6309
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6309
ggacuggcgu cucacauccg ug 22
<210> 6310
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6310
ggacuggggu guuggagguu ua 22
<210> 6311
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6311
ggacuuccag acccacaauc gc 22
<210> 6312
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6312
ggacuugcaa uuuucagugu gg 22
<210> 6313
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6313
ggacuuuaca agauuuggga gu 22
<210> 6314
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6314
ggagacucgg agguuuggac uu 22
<210> 6315
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6315
ggagaggauc cagugacugc cg 22
<210> 6316
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6316
ggaggaguug cugacgcugg uu 22
<210> 6317
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6317
ggagguuuag gcuggguuug gg 22
<210> 6318
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6318
ggagguuugg acuuuacaag au 22
<210> 6319
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6319
ggagucagcg ccuggcaggc ug 22
<210> 6320
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6320
ggagucaugg uggcugcugu cc 22
<210> 6321
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6321
ggagugggcu ugucauucca cg 22
<210> 6322
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6322
ggaguggggc acgggagugg gc 22
<210> 6323
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6323
ggaguguuua gagagguaga gg 22
<210> 6324
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6324
ggaguugcug acgcugguug ga 22
<210> 6325
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6325
ggaguuuaua uacauuuggg cu 22
<210> 6326
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6326
ggaguuugag uguuuacaua uu 22
<210> 6327
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6327
ggaguuugca gcuuggggac uu 22
<210> 6328
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6328
ggaguuuggg auguuucuag aa 22
<210> 6329
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6329
ggauccagug acugccggcg ca 22
<210> 6330
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6330
ggauccucuc caggaccaga gg 22
<210> 6331
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6331
ggaugugaga cgccaguccu ca 22
<210> 6332
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6332
ggaugugugg cccccucguu gc 22
<210> 6333
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6333
ggauguuucu agaauugagg uc 22
<210> 6334
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6334
ggauucaggg guuagcaggu ug 22
<210> 6335
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6335
ggauuccaca aacacccaac cc 22
<210> 6336
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6336
ggcaacgagg gggccacaca uc 22
<210> 6337
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6337
ggcaagugcg ccggcaguca cu 22
<210> 6338
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6338
ggcacacagc cugccaggcg cu 22
<210> 6339
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6339
ggcacgggag ugggcuuguc au 22
<210> 6340
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6340
ggcacugcca ccgucucaac ca 22
<210> 6341
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6341
ggcagcccaa auauauauaa uc 22
<210> 6342
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6342
ggcaggacag cagccaccau ga 22
<210> 6343
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6343
ggcaggcugu gugccccagc cu 22
<210> 6344
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6344
ggcagucacu ggauccucuc ca 22
<210> 6345
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6345
ggcagugccc agagaagaua au 22
<210> 6346
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6346
ggcaugugug gguuuaggcg au 22
<210> 6347
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6347
ggcauuggca agugcgccgg ca 22
<210> 6348
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6348
ggccacacau cccaccaaac cc 22
<210> 6349
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6349
ggccaggccc agcuggcuga ga 22
<210> 6350
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6350
ggcccagcug gcugagagug gg 22
<210> 6351
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6351
ggcccccucg uugcccaggc uu 22
<210> 6352
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6352
ggccuggccu uugaaagccu gg 22
<210> 6353
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6353
ggccuuugaa agccugggca ac 22
<210> 6354
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6354
ggcgauugug ggucuggaag uc 22
<210> 6355
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6355
ggcgcacuug ccaaugccau ua 22
<210> 6356
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6356
ggcgcugacu ccagugagga cu 22
<210> 6357
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6357
ggcguaugug gguuugggua gg 22
<210> 6358
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6358
ggcgucucac auccguggaa ug 22
<210> 6359
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6359
ggcuacuucg gguucaugua ua 22
<210> 6360
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6360
ggcugagagu gggagucaug gu 22
<210> 6361
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6361
ggcugccuga gaguuugggu gu 22
<210> 6362
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6362
ggcugcuguc cugcccaugu gg 22
<210> 6363
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6363
ggcuggggca cacagccugc ca 22
<210> 6364
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6364
ggcuggguuu ggggugcucu aa 22
<210> 6365
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6365
ggcugguucu gggguggaag ca 22
<210> 6366
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6366
ggcugugugc cccagccucu gg 22
<210> 6367
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6367
ggcuugucau uccacggaug ug 22
<210> 6368
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6368
ggcuuucaaa ggccaggccc ag 22
<210> 6369
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6369
gggaaugauu auauauauuu gg 22
<210> 6370
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6370
gggaccugga cccccaaaug uc 22
<210> 6371
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6371
gggacuugca auuuucagug ug 22
<210> 6372
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6372
gggagucaug guggcugcug uc 22
<210> 6373
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6373
gggagugggc uugucauucc ac 22
<210> 6374
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6374
gggaguuuga guguuuacau au 22
<210> 6375
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6375
gggaguuugc agcuugggga cu 22
<210> 6376
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6376
gggaugugug gcccccucgu ug 22
<210> 6377
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6377
gggauguuuc uagaauugag gu 22
<210> 6378
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6378
gggcaacgag ggggccacac au 22
<210> 6379
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6379
gggcacacag ccugccaggc gc 22
<210> 6380
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6380
gggcacggga gugggcuugu ca 22
<210> 6381
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6381
gggcacugcc accgucucaa cc 22
<210> 6382
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6382
gggcaggaca gcagccacca ug 22
<210> 6383
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6383
gggcaugugu ggguuuaggc ga 22
<210> 6384
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6384
gggccacaca ucccaccaaa cc 22
<210> 6385
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6385
gggccuggcc uuugaaagcc ug 22
<210> 6386
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6386
gggcugccug agaguuuggg ug 22
<210> 6387
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6387
gggcugguuc ugggguggaa gc 22
<210> 6388
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6388
gggcuuguca uuccacggau gu 22
<210> 6389
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6389
ggggacuugc aauuuucagu gu 22
<210> 6390
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6390
ggggcacaca gccugccagg cg 22
<210> 6391
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6391
ggggcacggg agugggcuug uc 22
<210> 6392
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6392
ggggcaugug uggguuuagg cg 22
<210> 6393
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6393
ggggcauuug gaauugauug ua 22
<210> 6394
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6394
ggggccacac aucccaccaa ac 22
<210> 6395
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6395
gggggccaca caucccacca aa 22
<210> 6396
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6396
ggggguccag gucccuguag aa 22
<210> 6397
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6397
gggguccagg ucccuguaga au 22
<210> 6398
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6398
ggggugcucu aagauuugag gu 22
<210> 6399
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6399
gggguggaag cagacauuug gg 22
<210> 6400
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6400
gggguguugg agguuuaggc ug 22
<210> 6401
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6401
gggguuagca gguugggaau ga 22
<210> 6402
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6402
ggguagguag aguugagggu gu 22
<210> 6403
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6403
ggguccaggu cccuguagaa uu 22
<210> 6404
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6404
gggucuggaa guccagagac uu 22
<210> 6405
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6405
gggugcauuu ggguguuugu gg 22
<210> 6406
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6406
gggugcucua agauuugagg uu 22
<210> 6407
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6407
ggguggaagc agacauuugg gg 22
<210> 6408
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6408
ggguguaugu gguguucauu ga 22
<210> 6409
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6409
ggguguccgg gaguuugagu gu 22
<210> 6410
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6410
ggguguugga gguuuaggcu gg 22
<210> 6411
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6411
ggguguuuau ggguugggug uu 22
<210> 6412
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6412
ggguguuugu ggaauccagg ua 22
<210> 6413
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6413
ggguguuugu ggauucaggg gu 22
<210> 6414
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6414
ggguuagcag guugggaaug au 22
<210> 6415
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6415
ggguucaugu auaguugggg ca 22
<210> 6416
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6416
ggguugggug uuuguggaau cc 22
<210> 6417
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6417
ggguuuaaag auuggcuacu uc 22
<210> 6418
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6418
ggguuuaggc gauugugggu cu 22
<210> 6419
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6419
ggguuugggg cauguguggg uu 22
<210> 6420
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6420
ggguuugggg ugcucuaaga uu 22
<210> 6421
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6421
ggguuugggu agguagaguu ga 22
<210> 6422
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6422
ggguuuggug ggaugugugg cc 22
<210> 6423
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6423
gguagagguu uaggguuugg gg 22
<210> 6424
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6424
gguagaguug aggguguccg gg 22
<210> 6425
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6425
gguagguaga guugagggug uc 22
<210> 6426
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6426
gguaucaugg aauuggaguu ua 22
<210> 6427
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6427
gguaucgugg aauuggaguu ua 22
<210> 6428
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6428
gguauggugg aauuggaguu ug 22
<210> 6429
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6429
ggucaucugu ugguuuaggg ug 22
<210> 6430
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6430
gguccagguc ccuguagaau uc 22
<210> 6431
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6431
ggucccugua gaauucaggg ug 22
<210> 6432
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6432
gguccuggag aggauccagu ga 22
<210> 6433
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6433
ggucuggaag uccagagacu ug 22
<210> 6434
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6434
ggugcauuug gguguuugug ga 22
<210> 6435
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6435
ggugcucuaa gauuugaggu uu 22
<210> 6436
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6436
gguggaagca gacauuuggg gg 22
<210> 6437
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6437
gguggaauug gaguuuggga ug 22
<210> 6438
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6438
gguggcagug cccagagaag au 22
<210> 6439
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6439
gguggcugcu guccugccca ug 22
<210> 6440
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6440
ggugggaugu guggcccccu cg 22
<210> 6441
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6441
gguguaugug guguucauug au 22
<210> 6442
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6442
gguguccggg aguuugagug uu 22
<210> 6443
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6443
gguguuggag guuuaggcug gg 22
<210> 6444
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6444
gguguuuaug gguugggugu uu 22
<210> 6445
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6445
gguguuugug gaauccaggu au 22
<210> 6446
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6446
gguguuugug gauucagggg uu 22
<210> 6447
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6447
gguuagcagg uugggaauga uu 22
<210> 6448
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6448
gguuaugacu cuacccacaa ac 22
<210> 6449
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6449
gguucagggu uuggugggau gu 22
<210> 6450
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6450
gguucaugua uaguuggggc au 22
<210> 6451
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6451
gguucugggg uggaagcaga ca 22
<210> 6452
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6452
gguugagacg guggcagugc cc 22
<210> 6453
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6453
gguuggaagg uucaggguuu gg 22
<210> 6454
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6454
gguugggaau gauuauauau au 22
<210> 6455
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6455
gguugggugu uuguggaauc ca 22
<210> 6456
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6456
gguuuaaaga uuggcuacuu cg 22
<210> 6457
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6457
gguuuagagg uuuuggcgua ug 22
<210> 6458
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6458
gguuuaggcg auuguggguc ug 22
<210> 6459
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6459
gguuuaggcu ggguuugggg ug 22
<210> 6460
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6460
gguuuagggu guauguggug uu 22
<210> 6461
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6461
gguuuagggu uuggggcaug ug 22
<210> 6462
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6462
gguuuggacu uuacaagauu ug 22
<210> 6463
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6463
gguuuggggc augugugggu uu 22
<210> 6464
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6464
gguuuggggu gcucuaagau uu 22
<210> 6465
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6465
gguuugggua gguagaguug ag 22
<210> 6466
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6466
gguuuggugg gauguguggc cc 22
<210> 6467
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6467
gguuuuggcg uauguggguu ug 22
<210> 6468
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6468
guaaacacuc aaacucccgg ac 22
<210> 6469
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6469
guagaauuca gggugcauuu gg 22
<210> 6470
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6470
guagagguuu aggguuuggg gc 22
<210> 6471
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6471
guagaguuga ggguguccgg ga 22
<210> 6472
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6472
guagccaauc uuuaaaccca ca 22
<210> 6473
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6473
guagguagag uugagggugu cc 22
<210> 6474
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6474
guauaguugg ggcauuugga au 22
<210> 6475
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6475
guauauaaac uccaauucca cg 22
<210> 6476
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6476
guauauaaac uccaauucca ug 22
<210> 6477
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6477
guaucgugga auuggaguuu au 22
<210> 6478
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6478
guauggugga auuggaguuu gg 22
<210> 6479
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6479
guaugugggu uuggguaggu ag 22
<210> 6480
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6480
guauguggug uucauugaug gu 22
<210> 6481
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6481
guauuuauua ggacuggggu gu 22
<210> 6482
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6482
gucacuggau ccucuccagg ac 22
<210> 6483
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6483
gucagcaacu ccuccaaguc uc 22
<210> 6484
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6484
gucagcgccu ggcaggcugu gu 22
<210> 6485
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6485
gucaucuguu gguuuagggu gu 22
<210> 6486
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6486
gucauggugg cugcuguccu gc 22
<210> 6487
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6487
gucauuccac ggaugugaga cg 22
<210> 6488
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6488
guccagagac uuggaggagu ug 22
<210> 6489
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6489
guccaggucc cuguagaauu ca 22
<210> 6490
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6490
guccccaagc ugcaaacucc ca 22
<210> 6491
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6491
gucccuguag aauucagggu gc 22
<210> 6492
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6492
guccgggagu uugaguguuu ac 22
<210> 6493
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6493
guccucacug gagucagcgc cu 22
<210> 6494
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6494
guccugccca ugugguugag ac 22
<210> 6495
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6495
guccuggaga ggauccagug ac 22
<210> 6496
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6496
gucggagugg ggcacgggag ug 22
<210> 6497
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6497
gucucaacca caugggcagg ac 22
<210> 6498
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6498
gucucacauc cguggaauga ca 22
<210> 6499
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6499
gucucuggac uuccagaccc ac 22
<210> 6500
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6500
gucugcuucc accccagaac ca 22
<210> 6501
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6501
gucuggaagu ccagagacuu gg 22
<210> 6502
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6502
gugacugccg gcgcacuugc ca 22
<210> 6503
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6503
gugagacgcc aguccucacu gg 22
<210> 6504
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6504
gugaggacug gcgucucaca uc 22
<210> 6505
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6505
gugagugguu augacucuac cc 22
<210> 6506
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6506
gugcauuugg guguuugugg au 22
<210> 6507
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6507
gugcccagag aagauaaugg ca 22
<210> 6508
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6508
gugccccagc cucugguccu gg 22
<210> 6509
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6509
gugcgccggc agucacugga uc 22
<210> 6510
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6510
gugcucuaag auuugagguu ua 22
<210> 6511
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6511
guggaagcag acauuugggg gu 22
<210> 6512
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6512
guggaaucca gguaucaugg aa 22
<210> 6513
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6513
guggaaucca gguaucgugg aa 22
<210> 6514
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6514
guggaaucca gguauggugg aa 22
<210> 6515
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6515
guggaaugac aagcccacuc cc 22
<210> 6516
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6516
guggaauugg aguuuauaua ca 22
<210> 6517
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6517
guggaauugg aguuugggau gu 22
<210> 6518
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6518
guggauucag ggguuagcag gu 22
<210> 6519
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6519
guggcagugc ccagagaaga ua 22
<210> 6520
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6520
guggcccccu cguugcccag gc 22
<210> 6521
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6521
guggcugcug uccugcccau gu 22
<210> 6522
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6522
gugggaguca ugguggcugc ug 22
<210> 6523
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6523
gugggaugug uggcccccuc gu 22
<210> 6524
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6524
gugggcuugu cauuccacgg au 22
<210> 6525
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6525
guggggcacg ggagugggcu ug 22
<210> 6526
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6526
gugggucugg aaguccagag ac 22
<210> 6527
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6527
guggguuuaa agauuggcua cu 22
<210> 6528
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6528
guggguuuag gcgauugugg gu 22
<210> 6529
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6529
guggguuugg guagguagag uu 22
<210> 6530
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6530
gugguguuca uugauggugc gg 22
<210> 6531
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6531
gugguuauga cucuacccac aa 22
<210> 6532
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6532
gugguugaga cgguggcagu gc 22
<210> 6533
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6533
guguaugugg uguucauuga ug 22
<210> 6534
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6534
guguccggga guuugagugu uu 22
<210> 6535
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6535
gugugcccca gccucugguc cu 22
<210> 6536
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6536
guguggcccc cucguugccc ag 22
<210> 6537
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6537
guguggguuu aaagauuggc ua 22
<210> 6538
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6538
guguggguuu aggcgauugu gg 22
<210> 6539
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6539
guguuggagg uuuaggcugg gu 22
<210> 6540
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6540
guguuuacau auuuggagug uu 22
<210> 6541
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6541
guguuuagag agguagaggu uu 22
<210> 6542
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6542
guguuuaugg guuggguguu ug 22
<210> 6543
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6543
guguuugugg aauccaggua uc 22
<210> 6544
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6544
guguuugugg aauccaggua ug 22
<210> 6545
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6545
guguuugugg auucaggggu ua 22
<210> 6546
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6546
guuagcaggu ugggaaugau ua 22
<210> 6547
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6547
guuaugacuc uacccacaaa ca 22
<210> 6548
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6548
guucaggguu uggugggaug ug 22
<210> 6549
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6549
guucauguau aguuggggca uu 22
<210> 6550
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6550
guucuggggu ggaagcagac au 22
<210> 6551
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6551
guugagacgg uggcagugcc ca 22
<210> 6552
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6552
guugagggug uccgggaguu ug 22
<210> 6553
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6553
guugcccagg cuuucaaagg cc 22
<210> 6554
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6554
guugcugacg cugguuggaa gg 22
<210> 6555
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6555
guuggaaggu ucaggguuug gu 22
<210> 6556
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6556
guuggagguu uaggcugggu uu 22
<210> 6557
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6557
guugggaaug auuauauaua uu 22
<210> 6558
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6558
guuggggcau uuggaauuga uu 22
<210> 6559
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6559
guuggguguu uguggaaucc ag 22
<210> 6560
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6560
guugguuuag gguguaugug gu 22
<210> 6561
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6561
guuuaaagau uggcuacuuc gg 22
<210> 6562
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6562
guuuacauau uuggaguguu ua 22
<210> 6563
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6563
guuuagagag guagagguuu ag 22
<210> 6564
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6564
guuuagaggu uuuggcguau gu 22
<210> 6565
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6565
guuuaggcga uugugggucu gg 22
<210> 6566
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6566
guuuaggcug gguuuggggu gc 22
<210> 6567
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6567
guuuagggug uauguggugu uc 22
<210> 6568
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6568
guuuaggguu uggggcaugu gu 22
<210> 6569
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6569
guuuauauac auuugggcug cc 22
<210> 6570
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6570
guuuaugggu uggguguuug ug 22
<210> 6571
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6571
guuucuagaa uugaggucau cu 22
<210> 6572
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6572
guuugagugu uuacauauuu gg 22
<210> 6573
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6573
guuugcagcu uggggacuug ca 22
<210> 6574
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6574
guuuggacuu uacaagauuu gg 22
<210> 6575
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6575
guuugggaug uuucuagaau ug 22
<210> 6576
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6576
guuuggggca uguguggguu ua 22
<210> 6577
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6577
guuuggggug cucuaagauu ug 22
<210> 6578
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6578
guuuggguag guagaguuga gg 22
<210> 6579
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6579
guuugggugu uuauggguug gg 22
<210> 6580
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6580
guuugguggg auguguggcc cc 22
<210> 6581
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6581
guuuguggaa uccagguauc au 22
<210> 6582
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6582
guuuguggaa uccagguauc gu 22
<210> 6583
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6583
guuuguggaa uccagguaug gu 22
<210> 6584
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6584
guuuguggau ucagggguua gc 22
<210> 6585
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6585
guuugugggu agagucauaa cc 22
<210> 6586
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6586
guuuuggcgu auguggguuu gg 22
<210> 6587
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6587
uaaacaccca aacucucagg ca 22
<210> 6588
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6588
uaaacacuca aacucccgga ca 22
<210> 6589
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6589
uaaaccaaca gaugaccuca au 22
<210> 6590
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6590
uaaacccaca caugccccaa ac 22
<210> 6591
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6591
uaaacccaca cugaaaauug ca 22
<210> 6592
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6592
uaaaccucaa aucuuagagc ac 22
<210> 6593
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6593
uaaaccucca acaccccagu cc 22
<210> 6594
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6594
uaaaccucua ccucucuaaa ca 22
<210> 6595
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6595
uaaacuccaa uuccacgaua cc 22
<210> 6596
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6596
uaaacuccaa uuccaugaua cc 22
<210> 6597
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6597
uaaagauugg cuacuucggg uu 22
<210> 6598
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6598
uaaauacaau caauuccaaa ug 22
<210> 6599
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6599
uaaccccuga auccacaaac ac 22
<210> 6600
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6600
uaagauuuga gguuuagagg uu 22
<210> 6601
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6601
uaaucauucc caaccugcua ac 22
<210> 6602
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6602
uaauggcauu ggcaagugcg cc 22
<210> 6603
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6603
uacaagauuu gggaguuugc ag 22
<210> 6604
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6604
uacaaucaau uccaaaugcc cc 22
<210> 6605
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6605
uacacccuaa accaacagau ga 22
<210> 6606
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6606
uacagggacc uggaccccca aa 22
<210> 6607
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6607
uacauauuug gaguguuuag ag 22
<210> 6608
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6608
uacaugaacc cgaaguagcc aa 22
<210> 6609
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6609
uacauuuggg cugccugaga gu 22
<210> 6610
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6610
uacauuuggg cugccuguga gu 22
<210> 6611
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6611
uacccaaacc cacauacgcc aa 22
<210> 6612
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6612
uacccacaaa cagggcuggu uc 22
<210> 6613
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6613
uaccuaccca aacccacaua cg 22
<210> 6614
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6614
uaccucucua aacacuccaa au 22
<210> 6615
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6615
uaccuggauu ccacaaacac cc 22
<210> 6616
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6616
uacgccaaaa ccucuaaacc uc 22
<210> 6617
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6617
uacuucgggu ucauguauag uu 22
<210> 6618
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6618
uagaaacauc ccaaacucca au 22
<210> 6619
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6619
uagaauucag ggugcauuug gg 22
<210> 6620
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6620
uagaauugag gucaucuguu gg 22
<210> 6621
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6621
uagagaggua gagguuuagg gu 22
<210> 6622
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6622
uagagcaccc caaacccagc cu 22
<210> 6623
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6623
uagagguuua ggguuugggg ca 22
<210> 6624
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6624
uagagguuuu ggcguaugug gg 22
<210> 6625
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6625
uagaguugag gguguccggg ag 22
<210> 6626
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6626
uagccaaucu uuaaacccac ac 22
<210> 6627
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6627
uaggacuggg guguuggagg uu 22
<210> 6628
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6628
uaggcgauug ugggucugga ag 22
<210> 6629
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6629
uaggcugggu uuggggugcu cu 22
<210> 6630
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6630
uaggguguau gugguguuca uu 22
<210> 6631
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6631
uaggguuugg ggcaugugug gg 22
<210> 6632
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6632
uagguagagu ugaggguguc cg 22
<210> 6633
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6633
uaguuggggc auuuggaauu ga 22
<210> 6634
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6634
uauaaacucc aauuccacga ua 22
<210> 6635
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6635
uauaaacucc aauuccauga ua 22
<210> 6636
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6636
uauaaucauu cccaaccugc ua 22
<210> 6637
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6637
uauacaugaa cccgaaguag cc 22
<210> 6638
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6638
uauacauuug ggcugccuga ga 22
<210> 6639
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6639
uauacauuug ggcugccugu ga 22
<210> 6640
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6640
uauaguuggg gcauuuggaa uu 22
<210> 6641
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6641
uauauaaacu ccaauuccac ga 22
<210> 6642
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6642
uauauaaacu ccaauuccau ga 22
<210> 6643
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6643
uauauaauca uucccaaccu gc 22
<210> 6644
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6644
uauauacauu ugggcugccu ga 22
<210> 6645
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6645
uauauacauu ugggcugccu gu 22
<210> 6646
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6646
uauauauaau cauucccaac cu 22
<210> 6647
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6647
uauauauauu ugggcugccu gu 22
<210> 6648
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6648
uauauauuug ggcugccugu ga 22
<210> 6649
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6649
uauauuuggg cugccuguga gu 22
<210> 6650
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6650
uaucuucucu gggcacugcc ac 22
<210> 6651
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6651
uaugacucua cccacaaaca gg 22
<210> 6652
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6652
uauggguugg guguuugugg aa 22
<210> 6653
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6653
uaugguggaa uuggaguuug gg 22
<210> 6654
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6654
uauguaaaca cucaaacucc cg 22
<210> 6655
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6655
uauguggguu uggguaggua ga 22
<210> 6656
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6656
uauguggugu ucauugaugg ug 22
<210> 6657
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6657
uauuaggacu gggguguugg ag 22
<210> 6658
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6658
uauuuauuag gacuggggug uu 22
<210> 6659
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6659
uauuuggagu guuuagagag gu 22
<210> 6660
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6660
uauuugggcu gccugugagu uu 22
<210> 6661
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6661
ucaaacuccc ggacacccuc aa 22
<210> 6662
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6662
ucaaaggcca ggcccagcug gc 22
<210> 6663
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6663
ucaaaucuua gagcacccca aa 22
<210> 6664
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6664
ucaaccacau gggcaggaca gc 22
<210> 6665
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6665
ucaacucuac cuacccaaac cc 22
<210> 6666
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6666
ucaaugaaca ccacauacac cc 22
<210> 6667
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6667
ucaauuccaa augccccaac ua 22
<210> 6668
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6668
ucaauucuag aaacauccca aa 22
<210> 6669
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6669
ucacaggcag cccaaauaua ua 22
<210> 6670
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6670
ucacaggcag cccaaaugua ua 22
<210> 6671
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6671
ucacauccgu ggaaugacaa gc 22
<210> 6672
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6672
ucacuggagu cagcgccugg ca 22
<210> 6673
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6673
ucacuggauc cucuccagga cc 22
<210> 6674
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6674
ucagcaacuc cuccaagucu cu 22
<210> 6675
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6675
ucagccagcu gggccuggcc uu 22
<210> 6676
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6676
ucagcgccug gcaggcugug ug 22
<210> 6677
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6677
ucaggcagcc caaauguaua ua 22
<210> 6678
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6678
ucagggguua gcagguuggg aa 22
<210> 6679
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6679
ucagggugca uuuggguguu ug 22
<210> 6680
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6680
ucaggguuug gugggaugug ug 22
<210> 6681
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6681
ucaguguggg uuuaaagauu gg 22
<210> 6682
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6682
ucaucuguug guuuagggug ua 22
<210> 6683
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6683
ucaugguggc ugcuguccug cc 22
<210> 6684
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6684
ucauguauag uuggggcauu ug 22
<210> 6685
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6685
ucauuccacg gaugugagac gc 22
<210> 6686
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6686
ucauucccaa ccugcuaacc cc 22
<210> 6687
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6687
uccaaauaug uaaacacuca aa 22
<210> 6688
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6688
uccaaaugcc ccaacuauac au 22
<210> 6689
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6689
uccaacaccc caguccuaau aa 22
<210> 6690
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6690
uccaaccagc gucagcaacu cc 22
<210> 6691
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6691
uccaagucuc uggacuucca ga 22
<210> 6692
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6692
uccaauucca ccauaccugg au 22
<210> 6693
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6693
uccaauucca cgauaccugg au 22
<210> 6694
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6694
uccaauucca ugauaccugg au 22
<210> 6695
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6695
uccacaaaca cccaaaugca cc 22
<210> 6696
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6696
uccacaaaca cccaacccau aa 22
<210> 6697
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6697
uccaccauac cuggauucca ca 22
<210> 6698
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6698
uccaccccag aaccagcccu gu 22
<210> 6699
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6699
uccacgauac cuggauucca ca 22
<210> 6700
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6700
uccacggaug ugagacgcca gu 22
<210> 6701
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6701
uccagaccca caaucgccua aa 22
<210> 6702
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6702
uccagagacu uggaggaguu gc 22
<210> 6703
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6703
uccaggacca gaggcugggg ca 22
<210> 6704
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6704
uccagguauc auggaauugg ag 22
<210> 6705
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6705
uccagguauc guggaauugg ag 22
<210> 6706
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6706
uccagguaug guggaauugg ag 22
<210> 6707
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6707
uccagguccc uguagaauuc ag 22
<210> 6708
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6708
uccagugacu gccggcgcac uu 22
<210> 6709
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6709
uccagugagg acuggcgucu ca 22
<210> 6710
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6710
uccaugauac cuggauucca ca 22
<210> 6711
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6711
ucccaaacuc caauuccacc au 22
<210> 6712
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6712
ucccaaaucu uguaaagucc aa 22
<210> 6713
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6713
ucccaaccug cuaaccccug aa 22
<210> 6714
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6714
ucccaccaaa cccugaaccu uc 22
<210> 6715
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6715
ucccacucuc agccagcugg gc 22
<210> 6716
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6716
uccccaagcu gcaaacuccc aa 22
<210> 6717
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6717
ucccggacac ccucaacucu ac 22
<210> 6718
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6718
ucccuguaga auucagggug ca 22
<210> 6719
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6719
uccgggaguu ugaguguuua ca 22
<210> 6720
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6720
uccguggaau gacaagccca cu 22
<210> 6721
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6721
uccucacugg agucagcgcc ug 22
<210> 6722
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6722
uccuccaagu cucuggacuu cc 22
<210> 6723
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6723
uccucuccag gaccagaggc ug 22
<210> 6724
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6724
uccugcccau gugguugaga cg 22
<210> 6725
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6725
uccuggagag gauccaguga cu 22
<210> 6726
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6726
ucgccuaaac ccacacaugc cc 22
<210> 6727
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6727
ucggagguuu ggacuuuaca ag 22
<210> 6728
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6728
ucggaguggg gcacgggagu gg 22
<210> 6729
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6729
ucggguucau guauaguugg gg 22
<210> 6730
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6730
ucguggaauu ggaguuuaua ua 22
<210> 6731
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6731
ucguugccca ggcuuucaaa gg 22
<210> 6732
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6732
ucuaaacacu ccaaauaugu aa 22
<210> 6733
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6733
ucuaaaccuc aaaucuuaga gc 22
<210> 6734
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6734
ucuaagauuu gagguuuaga gg 22
<210> 6735
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6735
ucuacaggga ccuggacccc ca 22
<210> 6736
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6736
ucuacccaca aacagggcug gu 22
<210> 6737
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6737
ucuaccuacc caaacccaca ua 22
<210> 6738
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6738
ucuaccucuc uaaacacucc aa 22
<210> 6739
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6739
ucuagaaaca ucccaaacuc ca 22
<210> 6740
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6740
ucuagaauug aggucaucug uu 22
<210> 6741
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6741
ucucaaccac augggcagga ca 22
<210> 6742
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6742
ucucacaucc guggaaugac aa 22
<210> 6743
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6743
ucucagccag cugggccugg cc 22
<210> 6744
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6744
ucucaggcag cccaaaugua ua 22
<210> 6745
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6745
ucuccaggac cagaggcugg gg 22
<210> 6746
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6746
ucucuaaaca cuccaaauau gu 22
<210> 6747
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6747
ucucuggacu uccagaccca ca 22
<210> 6748
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6748
ucucugggca cugccaccgu cu 22
<210> 6749
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6749
ucugcuucca ccccagaacc ag 22
<210> 6750
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6750
ucuggaaguc cagagacuug ga 22
<210> 6751
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6751
ucuggacuuc cagacccaca au 22
<210> 6752
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6752
ucugggcacu gccaccgucu ca 22
<210> 6753
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6753
ucuggggugg aagcagacau uu 22
<210> 6754
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6754
ucugguccug gagaggaucc ag 22
<210> 6755
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6755
ucuguugguu uaggguguau gu 22
<210> 6756
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6756
ucuuagagca ccccaaaccc ag 22
<210> 6757
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6757
ucuucucugg gcacugccac cg 22
<210> 6758
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6758
ucuuguaaag uccaaaccuc cg 22
<210> 6759
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6759
ucuuuaaacc cacacugaaa au 22
<210> 6760
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6760
ugaaaauugc aaguccccaa gc 22
<210> 6761
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6761
ugaaagccug ggcaacgagg gg 22
<210> 6762
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6762
ugaacaccac auacacccua aa 22
<210> 6763
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6763
ugaacccgaa guagccaauc uu 22
<210> 6764
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6764
ugaaccuucc aaccagcguc ag 22
<210> 6765
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6765
ugaauccaca aacacccaaa ug 22
<210> 6766
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6766
ugaauucuac agggaccugg ac 22
<210> 6767
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6767
ugacaagccc acucccgugc cc 22
<210> 6768
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6768
ugaccucaau ucuagaaaca uc 22
<210> 6769
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6769
ugacgcuggu uggaagguuc ag 22
<210> 6770
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6770
ugacuccagu gaggacuggc gu 22
<210> 6771
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6771
ugacucccac ucucagccag cu 22
<210> 6772
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6772
ugacucuacc cacaaacagg gc 22
<210> 6773
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6773
ugacugccgg cgcacuugcc aa 22
<210> 6774
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6774
ugagacgcca guccucacug ga 22
<210> 6775
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6775
ugagacggug gcagugccca ga 22
<210> 6776
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6776
ugagaguggg agucauggug gc 22
<210> 6777
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6777
ugagaguuug gguguuuaug gg 22
<210> 6778
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6778
ugaggacugg cgucucacau cc 22
<210> 6779
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6779
ugaggguguc cgggaguuug ag 22
<210> 6780
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6780
ugaggucauc uguugguuua gg 22
<210> 6781
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6781
ugagguuuag agguuuuggc gu 22
<210> 6782
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6782
ugagugguua ugacucuacc ca 22
<210> 6783
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6783
ugaguguuua cauauuugga gu 22
<210> 6784
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6784
ugauaccugg auuccacaaa ca 22
<210> 6785
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6785
ugauuauaua uauuugggcu gc 22
<210> 6786
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6786
ugauuguauu uauuaggacu gg 22
<210> 6787
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6787
ugcaaacucc caaaucuugu aa 22
<210> 6788
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6788
ugcaaguccc caagcugcaa ac 22
<210> 6789
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6789
ugcaauuuuc aguguggguu ua 22
<210> 6790
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6790
ugcacccuga auucuacagg ga 22
<210> 6791
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6791
ugcagcuugg ggacuugcaa uu 22
<210> 6792
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6792
ugcauuuggg uguuugugga uu 22
<210> 6793
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6793
ugccaaugcc auuaucuucu cu 22
<210> 6794
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6794
ugccaccguc ucaaccacau gg 22
<210> 6795
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6795
ugccaggcgc ugacuccagu ga 22
<210> 6796
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6796
ugccauuauc uucucugggc ac 22
<210> 6797
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6797
ugcccagaga agauaauggc au 22
<210> 6798
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6798
ugcccaggcu uucaaaggcc ag 22
<210> 6799
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6799
ugcccaugug guugagacgg ug 22
<210> 6800
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6800
ugccccaaac ccuaaaccuc ua 22
<210> 6801
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6801
ugccccaacu auacaugaac cc 22
<210> 6802
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6802
ugccccagcc ucugguccug ga 22
<210> 6803
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6803
ugccggcgca cuugccaaug cc 22
<210> 6804
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6804
ugccugagag uuuggguguu ua 22
<210> 6805
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6805
ugcgccggca gucacuggau cc 22
<210> 6806
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6806
ugcuaacccc ugaauccaca aa 22
<210> 6807
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6807
ugcucuaaga uuugagguuu ag 22
<210> 6808
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6808
ugcugacgcu gguuggaagg uu 22
<210> 6809
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6809
ugcuguccug cccauguggu ug 22
<210> 6810
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6810
ugcuuccacc ccagaaccag cc 22
<210> 6811
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6811
uggaagcaga cauuuggggg uc 22
<210> 6812
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6812
uggaagguuc aggguuuggu gg 22
<210> 6813
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6813
uggaagucca gagacuugga gg 22
<210> 6814
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6814
uggaauccag guaucaugga au 22
<210> 6815
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6815
uggaauccag guaucgugga au 22
<210> 6816
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6816
uggaauccag guauggugga au 22
<210> 6817
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6817
uggaaugaca agcccacucc cg 22
<210> 6818
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6818
uggaauugau uguauuuauu ag 22
<210> 6819
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6819
uggaauugga guuugggaug uu 22
<210> 6820
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6820
uggaccccca aaugucugcu uc 22
<210> 6821
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6821
uggacuucca gacccacaau cg 22
<210> 6822
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6822
uggacuuuac aagauuuggg ag 22
<210> 6823
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6823
uggagacucg gagguuugga cu 22
<210> 6824
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6824
uggagaggau ccagugacug cc 22
<210> 6825
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6825
uggaggaguu gcugacgcug gu 22
<210> 6826
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6826
uggagguuua ggcuggguuu gg 22
<210> 6827
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6827
uggagucagc gccuggcagg cu 22
<210> 6828
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6828
uggaguguuu agagagguag ag 22
<210> 6829
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6829
uggaguuugg gauguuucua ga 22
<210> 6830
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6830
uggauccucu ccaggaccag ag 22
<210> 6831
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6831
uggauucagg gguuagcagg uu 22
<210> 6832
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6832
uggauuccac aaacacccaa cc 22
<210> 6833
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6833
uggcaagugc gccggcaguc ac 22
<210> 6834
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6834
uggcaggcug ugugccccag cc 22
<210> 6835
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6835
uggcagugcc cagagaagau aa 22
<210> 6836
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6836
uggcauuggc aagugcgccg gc 22
<210> 6837
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6837
uggcccccuc guugcccagg cu 22
<210> 6838
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6838
uggccuuuga aagccugggc aa 22
<210> 6839
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6839
uggcguaugu ggguuugggu ag 22
<210> 6840
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6840
uggcgucuca cauccgugga au 22
<210> 6841
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6841
uggcuacuuc ggguucaugu au 22
<210> 6842
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6842
uggcugagag ugggagucau gg 22
<210> 6843
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6843
uggcugcugu ccugcccaug ug 22
<210> 6844
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6844
ugggaaugau uauauauauu ug 22
<210> 6845
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6845
ugggagucau gguggcugcu gu 22
<210> 6846
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6846
ugggaguuug cagcuugggg ac 22
<210> 6847
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6847
ugggaugugu ggcccccucg uu 22
<210> 6848
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6848
ugggauguuu cuagaauuga gg 22
<210> 6849
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6849
ugggcaacga gggggccaca ca 22
<210> 6850
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6850
ugggcacugc caccgucuca ac 22
<210> 6851
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6851
ugggcaggac agcagccacc au 22
<210> 6852
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6852
ugggccuggc cuuugaaagc cu 22
<210> 6853
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6853
ugggcugccu gagaguuugg gu 22
<210> 6854
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6854
ugggcuuguc auuccacgga ug 22
<210> 6855
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6855
uggggacuug caauuuucag ug 22
<210> 6856
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6856
uggggcacac agccugccag gc 22
<210> 6857
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6857
uggggcacgg gagugggcuu gu 22
<210> 6858
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6858
uggggcaugu guggguuuag gc 22
<210> 6859
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6859
uggggcauuu ggaauugauu gu 22
<210> 6860
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6860
ugggggucca ggucccugua ga 22
<210> 6861
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6861
uggggugcuc uaagauuuga gg 22
<210> 6862
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6862
ugggguggaa gcagacauuu gg 22
<210> 6863
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6863
ugggguguug gagguuuagg cu 22
<210> 6864
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6864
uggguaggua gaguugaggg ug 22
<210> 6865
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6865
ugggucugga aguccagaga cu 22
<210> 6866
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6866
uggguguuua uggguugggu gu 22
<210> 6867
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6867
uggguguuug uggaauccag gu 22
<210> 6868
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6868
uggguguuug uggauucagg gg 22
<210> 6869
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6869
uggguugggu guuuguggaa uc 22
<210> 6870
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6870
uggguuuaaa gauuggcuac uu 22
<210> 6871
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6871
uggguuuagg cgauuguggg uc 22
<210> 6872
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6872
uggguuuggg gugcucuaag au 22
<210> 6873
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6873
uggguuuggg uagguagagu ug 22
<210> 6874
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6874
ugguccugga gaggauccag ug 22
<210> 6875
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6875
ugguggaauu ggaguuuggg au 22
<210> 6876
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6876
ugguggcugc uguccugccc au 22
<210> 6877
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6877
uggugggaug uguggccccc uc 22
<210> 6878
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6878
ugguuaugac ucuacccaca aa 22
<210> 6879
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6879
ugguucuggg guggaagcag ac 22
<210> 6880
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6880
ugguugagac gguggcagug cc 22
<210> 6881
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6881
ugguuggaag guucaggguu ug 22
<210> 6882
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6882
ugguuuaggg uguauguggu gu 22
<210> 6883
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6883
uguaaacacu caaacucccg ga 22
<210> 6884
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6884
uguaaagucc aaaccuccga gu 22
<210> 6885
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6885
uguagaauuc agggugcauu ug 22
<210> 6886
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6886
uguauaguug gggcauuugg aa 22
<210> 6887
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6887
uguauauaaa cuccaauucc ac 22
<210> 6888
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6888
uguauauaaa cuccaauucc au 22
<210> 6889
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6889
uguauguggu guucauugau gg 22
<210> 6890
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6890
uguauuuauu aggacugggg ug 22
<210> 6891
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6891
ugucauucca cggaugugag ac 22
<210> 6892
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6892
uguccgggag uuugaguguu ua 22
<210> 6893
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6893
uguccugccc augugguuga ga 22
<210> 6894
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6894
ugucggagug gggcacggga gu 22
<210> 6895
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6895
ugucugcuuc caccccagaa cc 22
<210> 6896
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6896
ugugagacgc caguccucac ug 22
<210> 6897
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6897
ugugccccag ccucuggucc ug 22
<210> 6898
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6898
uguggaaucc agguaucaug ga 22
<210> 6899
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6899
uguggaaucc agguaucgug ga 22
<210> 6900
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6900
uguggaaucc agguauggug ga 22
<210> 6901
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6901
uguggauuca gggguuagca gg 22
<210> 6902
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6902
uguggccccc ucguugccca gg 22
<210> 6903
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6903
ugugggucug gaaguccaga ga 22
<210> 6904
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6904
uguggguuua aagauuggcu ac 22
<210> 6905
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6905
uguggguuua ggcgauugug gg 22
<210> 6906
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6906
uguggguuug gguagguaga gu 22
<210> 6907
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6907
ugugguguuc auugauggug cg 22
<210> 6908
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6908
ugugguugag acgguggcag ug 22
<210> 6909
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6909
ugugugcccc agccucuggu cc 22
<210> 6910
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6910
uguguggccc ccucguugcc ca 22
<210> 6911
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6911
uguguggguu uaggcgauug ug 22
<210> 6912
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6912
uguuggaggu uuaggcuggg uu 22
<210> 6913
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6913
uguugguuua ggguguaugu gg 22
<210> 6914
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6914
uguuuacaua uuuggagugu uu 22
<210> 6915
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6915
uguuuagaga gguagagguu ua 22
<210> 6916
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6916
uguuuauggg uuggguguuu gu 22
<210> 6917
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6917
uguuucuaga auugagguca uc 22
<210> 6918
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6918
uguuugugga auccagguau ca 22
<210> 6919
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6919
uguuugugga auccagguau cg 22
<210> 6920
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6920
uguuugugga auccagguau gg 22
<210> 6921
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6921
uguuugugga uucagggguu ag 22
<210> 6922
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6922
uguuuguggg uagagucaua ac 22
<210> 6923
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6923
uuaaacccac acugaaaauu gc 22
<210> 6924
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6924
uuaaagauug gcuacuucgg gu 22
<210> 6925
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6925
uuacaagauu ugggaguuug ca 22
<210> 6926
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6926
uuacauauuu ggaguguuua ga 22
<210> 6927
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6927
uuagagaggu agagguuuag gg 22
<210> 6928
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6928
uuagagcacc ccaaacccag cc 22
<210> 6929
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6929
uuagagguuu uggcguaugu gg 22
<210> 6930
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6930
uuaggacugg gguguuggag gu 22
<210> 6931
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6931
uuaggcgauu gugggucugg aa 22
<210> 6932
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6932
uuaggcuggg uuuggggugc uc 22
<210> 6933
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6933
uuagggugua ugugguguuc au 22
<210> 6934
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6934
uuaggguuug gggcaugugu gg 22
<210> 6935
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6935
uuauauacau uugggcugcc ug 22
<210> 6936
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6936
uuauauauau uugggcugcc ug 22
<210> 6937
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6937
uuaucuucuc ugggcacugc ca 22
<210> 6938
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6938
uuaugacucu acccacaaac ag 22
<210> 6939
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6939
uuauggguug gguguuugug ga 22
<210> 6940
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6940
uuauuaggac ugggguguug ga 22
<210> 6941
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6941
uucaaaggcc aggcccagcu gg 22
<210> 6942
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6942
uucagggguu agcagguugg ga 22
<210> 6943
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6943
uucagggugc auuugggugu uu 22
<210> 6944
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6944
uucaggguuu ggugggaugu gu 22
<210> 6945
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6945
uucagugugg guuuaaagau ug 22
<210> 6946
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6946
uucauguaua guuggggcau uu 22
<210> 6947
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6947
uuccaaaugc cccaacuaua ca 22
<210> 6948
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6948
uuccaaccag cgucagcaac uc 22
<210> 6949
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6949
uuccacaaac acccaaccca ua 22
<210> 6950
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6950
uuccaccaua ccuggauucc ac 22
<210> 6951
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6951
uuccacccca gaaccagccc ug 22
<210> 6952
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6952
uuccacgaua ccuggauucc ac 22
<210> 6953
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6953
uuccacggau gugagacgcc ag 22
<210> 6954
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6954
uuccagaccc acaaucgccu aa 22
<210> 6955
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6955
uuccaugaua ccuggauucc ac 22
<210> 6956
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6956
uucccaaccu gcuaaccccu ga 22
<210> 6957
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6957
uucggguuca uguauaguug gg 22
<210> 6958
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6958
uucuacaggg accuggaccc cc 22
<210> 6959
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6959
uucuagaaac aucccaaacu cc 22
<210> 6960
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6960
uucuagaauu gaggucaucu gu 22
<210> 6961
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6961
uucucugggc acugccaccg uc 22
<210> 6962
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6962
uucuggggug gaagcagaca uu 22
<210> 6963
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6963
uugaaagccu gggcaacgag gg 22
<210> 6964
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6964
uugagacggu ggcagugccc ag 22
<210> 6965
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6965
uugagggugu ccgggaguuu ga 22
<210> 6966
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6966
uugaggucau cuguugguuu ag 22
<210> 6967
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6967
uugagguuua gagguuuugg cg 22
<210> 6968
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6968
uugauuguau uuauuaggac ug 22
<210> 6969
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6969
uugcaagucc ccaagcugca aa 22
<210> 6970
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6970
uugcaauuuu cagugugggu uu 22
<210> 6971
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6971
uugcagcuug gggacuugca au 22
<210> 6972
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6972
uugccaaugc cauuaucuuc uc 22
<210> 6973
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6973
uugcccaggc uuucaaaggc ca 22
<210> 6974
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6974
uugcugacgc ugguuggaag gu 22
<210> 6975
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6975
uuggaagguu caggguuugg ug 22
<210> 6976
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6976
uuggacuuua caagauuugg ga 22
<210> 6977
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6977
uuggagacuc ggagguuugg ac 22
<210> 6978
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6978
uuggaggagu ugcugacgcu gg 22
<210> 6979
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6979
uuggagguuu aggcuggguu ug 22
<210> 6980
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6980
uuggaguguu uagagaggua ga 22
<210> 6981
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6981
uuggaguuug ggauguuucu ag 22
<210> 6982
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6982
uuggcaagug cgccggcagu ca 22
<210> 6983
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6983
uuggcguaug uggguuuggg ua 22
<210> 6984
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6984
uuggcuacuu cggguucaug ua 22
<210> 6985
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6985
uugggaauga uuauauauau uu 22
<210> 6986
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6986
uugggaguuu gcagcuuggg ga 22
<210> 6987
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6987
uugggauguu ucuagaauug ag 22
<210> 6988
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6988
uugggcugcc ugagaguuug gg 22
<210> 6989
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6989
uuggggacuu gcaauuuuca gu 22
<210> 6990
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6990
uuggggcaug uguggguuua gg 22
<210> 6991
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6991
uuggggcauu uggaauugau ug 22
<210> 6992
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6992
uugggggucc aggucccugu ag 22
<210> 6993
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6993
uuggggugcu cuaagauuug ag 22
<210> 6994
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6994
uuggguaggu agaguugagg gu 22
<210> 6995
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6995
uuggguguuu auggguuggg ug 22
<210> 6996
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6996
uuggguguuu guggaaucca gg 22
<210> 6997
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6997
uuggguguuu guggauucag gg 22
<210> 6998
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6998
uuggugggau guguggcccc cu 22
<210> 6999
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 6999
uugguuuagg guguaugugg ug 22
<210> 7000
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7000
uuguaaaguc caaaccuccg ag 22
<210> 7001
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7001
uuguauuuau uaggacuggg gu 22
<210> 7002
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7002
uugucauucc acggauguga ga 22
<210> 7003
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7003
uuguggaauc cagguaucau gg 22
<210> 7004
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7004
uuguggaauc cagguaucgu gg 22
<210> 7005
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7005
uuguggaauc cagguauggu gg 22
<210> 7006
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7006
uuguggauuc agggguuagc ag 22
<210> 7007
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7007
uugugggucu ggaaguccag ag 22
<210> 7008
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7008
uuuaaaccca cacugaaaau ug 22
<210> 7009
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7009
uuuaaagauu ggcuacuucg gg 22
<210> 7010
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7010
uuuacaagau uugggaguuu gc 22
<210> 7011
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7011
uuuacauauu uggaguguuu ag 22
<210> 7012
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7012
uuuagagagg uagagguuua gg 22
<210> 7013
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7013
uuuagagguu uuggcguaug ug 22
<210> 7014
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7014
uuuaggcgau ugugggucug ga 22
<210> 7015
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7015
uuuaggcugg guuuggggug cu 22
<210> 7016
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7016
uuuagggugu augugguguu ca 22
<210> 7017
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7017
uuuaggguuu ggggcaugug ug 22
<210> 7018
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7018
uuuauauaca uuugggcugc cu 22
<210> 7019
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7019
uuuauggguu ggguguuugu gg 22
<210> 7020
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7020
uuuauuagga cugggguguu gg 22
<210> 7021
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7021
uuucaaaggc caggcccagc ug 22
<210> 7022
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7022
uuucagugug gguuuaaaga uu 22
<210> 7023
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7023
uuucuagaau ugaggucauc ug 22
<210> 7024
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7024
uuugaaagcc ugggcaacga gg 22
<210> 7025
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7025
uuugagguuu agagguuuug gc 22
<210> 7026
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7026
uuugcagcuu ggggacuugc aa 22
<210> 7027
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7027
uuuggacuuu acaagauuug gg 22
<210> 7028
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7028
uuuggagacu cggagguuug ga 22
<210> 7029
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7029
uuuggagugu uuagagaggu ag 22
<210> 7030
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7030
uuuggcguau guggguuugg gu 22
<210> 7031
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7031
uuugggaguu ugcagcuugg gg 22
<210> 7032
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7032
uuugggaugu uucuagaauu ga 22
<210> 7033
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7033
uuugggcugc cugagaguuu gg 22
<210> 7034
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7034
uuuggggcau guguggguuu ag 22
<210> 7035
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7035
uuuggggguc caggucccug ua 22
<210> 7036
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7036
uuuggggugc ucuaagauuu ga 22
<210> 7037
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7037
uuuggguagg uagaguugag gg 22
<210> 7038
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7038
uuuggguguu uauggguugg gu 22
<210> 7039
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7039
uuuggguguu uguggauuca gg 22
<210> 7040
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7040
uuugguggga uguguggccc cc 22
<210> 7041
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7041
uuuguggaau ccagguauca ug 22
<210> 7042
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7042
uuuguggaau ccagguaucg ug 22
<210> 7043
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7043
uuuguggaau ccagguaugg ug 22
<210> 7044
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7044
uuuguggauu cagggguuag ca 22
<210> 7045
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7045
uuuucagugu ggguuuaaag au 22
<210> 7046
<211> 22
<212> RNA
<213> Artificial Sequence
<220>
<223> C3-targeting RNA guide sequence portion
<400> 7046
uuuuggcgua uguggguuug gg 22
<210> 7047
<211> 20
<212> RNA
<213> Artificial Sequence
<220>
<223> Example RNA guide sequence portion
<400> 7047
aaaaaaaugu acuugguucc 20
<210> 7048
<211> 17
<212> RNA
<213> Artificial Sequence
<220>
<223> 17 nucleotide guide sequence 1
<400> 7048
aaaauguacu ugguucc 17
<210> 7049
<211> 17
<212> RNA
<213> Artificial Sequence
<220>
<223> 17 nucleotide guide sequence 2
<400> 7049
aaaaauguac uugguuc 17
<210> 7050
<211> 17
<212> RNA
<213> Artificial Sequence
<220>
<223> 17 nucleotide guide sequence 3
<400> 7050
aaaaaaugua cuugguu 17
<210> 7051
<211> 17
<212> RNA
<213> Artificial Sequence
<220>
<223> 17 nucleotide guide sequence 4
<400> 7051
aaaaaaaugu acuuggu 17
<210> 7052
<211> 2980
<212> DNA
<213> Artificial Sequence
<220>
<223> 927-nucleotide homology arm HDR template
<400> 7052
tggggcagcc ccaaaagggg agaggccatg gggagaaggg ggggctgagt gggggaaagg 60
caggagccag ataaaaagcc agctccagca ggcgctgctc actcctcccc atcctctccc 120
tctgtccctc tgtccctctg accctgcact gtcccagcac catgggaccc acctcaggtc 180
ccagcctgct gctcctgcta ctaacccacc tccccctggc tctggggagt cccatgtgag 240
tggttatgac tctacccaca aacagggctg gttctggggt ggaagcagac atttgggggt 300
ccaggtccct gtagaattca gggtgcattt gggtgtttgt ggattcaggg gttagcaggt 360
tgggaatgat tatatatatt tgggctgcct gtgagtttgg gtgtttgtgg ttgggtgttt 420
gtggaatcca ggtatcatgg aattggagtt tatatacatt tgggctgcct gtgagtttgg 480
gtgtttgtgg ttgggtgttt gtggaatcca ggtatcgtgg aattggagtt tatatacatt 540
tgggctgcct gagagtttgg gtgtttatgg gttgggtgtt tgtggaatcc aggtatggtg 600
gaattggagt ttgggatgtt tctagaattg aggtcatctg ttggtttagg gtgtatgtgg 660
tgttcattga tggtgcggtt gggggtgttt ggagactcgg aggtttggac tttacaagat 720
ttgggagttt gcagcttggg gacttgcaat tttcagtgtg ggtttaaaga ttggctactt 780
cgggttcatg tatagttggg gcatttggaa ttgattgtat ttattaggac tggggtgttg 840
gaggtttagg ctgggtttgg ggtgctctaa gatttgaggt ttagaggttt tggcgtatgt 900
gggtttgggt aggtagagtt gagggtgtac tgacatccac tttgcctttc tctccacagg 960
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac 1020
ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac 1080
ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc 1140
ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag 1200
cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc 1260
ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg 1320
gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac 1380
aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac 1440
ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc 1500
gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac 1560
tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc 1620
ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaaggga 1680
tcctacccat acgatgttcc agattacgcg tagtcgagtc tagagggccc gtttaaaccc 1740
gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg 1800
tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa 1860
ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca 1920
gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg 1980
tccgggagtt tgagtgttta catatttgga gtgtttagag aggtagaggt ttagggtttg 2040
gggcatgtgt gggtttaggc gattgtgggt ctggaagtcc agagacttgg aggagttgct 2100
gacgctggtt ggaaggttca gggtttggtg ggatgtgtgg ccccctcgtt gcccaggctt 2160
tcaaaggcca ggcccagctg gctgagagtg ggagtcatgg tggctgctgt cctgcccatg 2220
tggttgagac ggtggcagtg cccagagaag ataatggcat tggcaagtgc gccggcagtc 2280
actggatcct ctccaggacc agaggctggg gcacacagcc tgccaggcgc tgactccagt 2340
gaggactggc gtctcacatc cgtggaatga caagcccact cccgtgcccc actccgacag 2400
gtactctatc atcaccccca acatcttgcg gctggagagc gaggagacca tggtgctgga 2460
ggcccacgac gcgcaagggg atgttccagt cactgttact gtccacgact tcccaggcaa 2520
aaaactagtg ctgtccagtg agaagactgt gctgacccct gccaccaacc acatgggcaa 2580
cgtcaccttc acggtgagtg cagactggcg caggacccgg ctgacaccca cagccacgcc 2640
cactcccccc ctcctcctga gcccctcccc ttctgtcttc tccctttcta agccctgccc 2700
ttccctgaga ctccacccct tcggagtcgc ctctccttct aagcccctcc cttctctgag 2760
actccacccc ttctgagtct cctcccctta taagcccctc ccttttctga gacccccccc 2820
caccccttct gaatctcctc cccttctaag ccctgacctt ccctgagacc ccaccccttc 2880
tgagactcct ccccttctga gtccctccct tccctgagac cccacccctt ctgaggttcc 2940
tccccttctc tgagactcca ccccttctga gtctcctccc 2980
<210> 7053
<211> 2653
<212> DNA
<213> Artificial Sequence
<220>
<223> 800-nucleotide homology arm HDR template
<400> 7053
ctctgtccct ctgaccctgc actgtcccag caccatggga cccacctcag gtcccagcct 60
gctgctcctg ctactaaccc acctccccct ggctctgggg agtcccatgt gagtggttat 120
gactctaccc acaaacaggg ctggttctgg ggtggaagca gacatttggg ggtccaggtc 180
cctgtagaat tcagggtgca tttgggtgtt tgtggattca ggggttagca ggttgggaat 240
gattatatat atttgggctg cctgtgagtt tgggtgtttg tggttgggtg tttgtggaat 300
ccaggtatca tggaattgga gtttatatac atttgggctg cctgtgagtt tgggtgtttg 360
tggttgggtg tttgtggaat ccaggtatcg tggaattgga gtttatatac atttgggctg 420
cctgagagtt tgggtgttta tgggttgggt gtttgtggaa tccaggtatg gtggaattgg 480
agtttgggat gtttctagaa ttgaggtcat ctgttggttt agggtgtatg tggtgttcat 540
tgatggtgcg gttgggggtg tttggagact cggaggtttg gactttacaa gatttgggag 600
tttgcagctt ggggacttgc aattttcagt gtgggtttaa agattggcta cttcgggttc 660
atgtatagtt ggggcatttg gaattgattg tatttattag gactggggtg ttggaggttt 720
aggctgggtt tggggtgctc taagatttga ggtttagagg ttttggcgta tgtgggtttg 780
ggtaggtaga gttgagggtg tactgacatc cactttgcct ttctctccac aggatggtga 840
gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg 900
taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc 960
tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga 1020
ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg 1080
acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg 1140
acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc 1200
gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg 1260
agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca 1320
aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact 1380
accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga 1440
gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg 1500
agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag ggatcctacc 1560
catacgatgt tccagattac gcgtagtcga gtctagaggg cccgtttaaa cccgctgatc 1620
agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc 1680
cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc 1740
gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg 1800
ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggtccggga 1860
gtttgagtgt ttacatattt ggagtgttta gagaggtaga ggtttagggt ttggggcatg 1920
tgtgggttta ggcgattgtg ggtctggaag tccagagact tggaggagtt gctgacgctg 1980
gttggaaggt tcagggtttg gtgggatgtg tggccccctc gttgcccagg ctttcaaagg 2040
ccaggcccag ctggctgaga gtgggagtca tggtggctgc tgtcctgccc atgtggttga 2100
gacggtggca gtgcccagag aagataatgg cattggcaag tgcgccggca gtcactggat 2160
cctctccagg accagaggct ggggcacaca gcctgccagg cgctgactcc agtgaggact 2220
ggcgtctcac atccgtggaa tgacaagccc actcccgtgc cccactccga caggtactct 2280
atcatcaccc ccaacatctt gcggctggag agcgaggaga ccatggtgct ggaggcccac 2340
gacgcgcaag gggatgttcc agtcactgtt actgtccacg acttcccagg caaaaaacta 2400
gtgctgtcca gtgagaagac tgtgctgacc cctgccacca accacatggg caacgtcacc 2460
ttcacggtga gtgcagactg gcgcaggacc cggctgacac ccacagccac gcccactccc 2520
cccctcctcc tgagcccctc cccttctgtc ttctcccttt ctaagccctg cccttccctg 2580
agactccacc ccttcggagt cgcctctcct tctaagcccc tcccttctct gagactccac 2640
cccttctgag tct 2653
<210> 7054
<211> 2053
<212> DNA
<213> Artificial Sequence
<220>
<223> 500-nucleotide homology arm HDR template
<400> 7054
ccaggtatca tggaattgga gtttatatac atttgggctg cctgtgagtt tgggtgtttg 60
tggttgggtg tttgtggaat ccaggtatcg tggaattgga gtttatatac atttgggctg 120
cctgagagtt tgggtgttta tgggttgggt gtttgtggaa tccaggtatg gtggaattgg 180
agtttgggat gtttctagaa ttgaggtcat ctgttggttt agggtgtatg tggtgttcat 240
tgatggtgcg gttgggggtg tttggagact cggaggtttg gactttacaa gatttgggag 300
tttgcagctt ggggacttgc aattttcagt gtgggtttaa agattggcta cttcgggttc 360
atgtatagtt ggggcatttg gaattgattg tatttattag gactggggtg ttggaggttt 420
aggctgggtt tggggtgctc taagatttga ggtttagagg ttttggcgta tgtgggtttg 480
ggtaggtaga gttgagggtg tactgacatc cactttgcct ttctctccac aggatggtga 540
gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg 600
taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc 660
tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga 720
ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg 780
acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg 840
acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc 900
gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg 960
agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca 1020
aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact 1080
accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga 1140
gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg 1200
agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag ggatcctacc 1260
catacgatgt tccagattac gcgtagtcga gtctagaggg cccgtttaaa cccgctgatc 1320
agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc 1380
cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc 1440
gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg 1500
ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggtccggga 1560
gtttgagtgt ttacatattt ggagtgttta gagaggtaga ggtttagggt ttggggcatg 1620
tgtgggttta ggcgattgtg ggtctggaag tccagagact tggaggagtt gctgacgctg 1680
gttggaaggt tcagggtttg gtgggatgtg tggccccctc gttgcccagg ctttcaaagg 1740
ccaggcccag ctggctgaga gtgggagtca tggtggctgc tgtcctgccc atgtggttga 1800
gacggtggca gtgcccagag aagataatgg cattggcaag tgcgccggca gtcactggat 1860
cctctccagg accagaggct ggggcacaca gcctgccagg cgctgactcc agtgaggact 1920
ggcgtctcac atccgtggaa tgacaagccc actcccgtgc cccactccga caggtactct 1980
atcatcaccc ccaacatctt gcggctggag agcgaggaga ccatggtgct ggaggcccac 2040
gacgcgcaag ggg 2053
<210> 7055
<211> 1062
<212> PRT
<213> Unknown
<220>
<223> OMNI-79 CRISPR Nuclease
<400> 7055
Met Glu Lys Arg Leu Gly Leu Asp Ile Gly Thr Asn Ser Ile Gly Trp
1 5 10 15
Cys Leu Tyr Glu Gly Asp Ser Ile Leu Asp Ile Gly Val Arg Ile Phe
20 25 30
Ser Asp Gly Arg Asp Pro Lys Ser Gly Ala Ser Leu Ala Val Asp Arg
35 40 45
Arg Asn Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Tyr Leu Gly Arg
50 55 60
Arg Ser Ala Leu Ile Lys Ala Leu Lys Ala His Gly Leu Phe Pro Ala
65 70 75 80
Glu Gln Asp Ala Ala Lys Ala Leu Glu Arg Glu Asp Pro Tyr Ser Leu
85 90 95
Arg Val Arg Ala Leu Asp His Arg Leu Asp Pro His Gln Ile Gly Arg
100 105 110
Ala Ile Phe His Leu Asn Gln Arg Arg Gly Phe Arg Ser Asn Arg Lys
115 120 125
Ala Asp Arg Val Leu Gly Asp Gln Glu Ser Gly Leu Ile Ser Thr Ala
130 135 140
Thr Arg Val Leu Asp Glu Ala Met Ala Lys Ser Gly Ala Arg Thr Leu
145 150 155 160
Gly Glu Phe Leu Ala Ser Arg Asp Thr Arg Arg Val Arg Met Arg Pro
165 170 175
Asp Val Lys Gly Tyr Asp Phe Tyr Pro Asn Arg Gln His Tyr Leu Glu
180 185 190
Glu Phe Glu Lys Ile Trp Asp Ala Gln Ser Gln Tyr His Pro Asp Leu
195 200 205
Leu Ser Gln Gln Ala Lys Ser Ala Ile His Arg Ile Ile Phe His Gln
210 215 220
Arg Pro Leu Lys Pro Gln Ala Val Gly Thr Cys Thr Phe Ala Gly Leu
225 230 235 240
His Gly Ile Pro Gly Asp Glu Thr Arg Leu Pro Lys Ala His Pro Leu
245 250 255
Phe Gln Gln Arg Arg Leu Tyr Glu Glu Val Asn Gln Leu Glu Ile Val
260 265 270
Cys Ala Ser Ala Pro Ala Arg Lys Leu Thr Arg Asp Glu Arg Asp Ala
275 280 285
Leu Ile Leu Lys Leu Gln Asp Lys Lys Lys Val Thr Phe Ser Thr Leu
290 295 300
Ala Arg Thr Ile Arg Leu Lys Glu Gly Glu Arg Phe Asn Lys Glu Ser
305 310 315 320
Glu Asn Arg Lys Asp Leu Ala Gly Asp Glu Val Arg Ala Glu Met Ser
325 330 335
Asp Lys Thr Arg Phe Gly Arg Arg Trp Phe His Leu Ser Leu Asp Glu
340 345 350
Gln Trp Ser Val Ile Asp Arg Leu Leu Asn Glu Glu Ser Thr Glu Asp
355 360 365
Leu Leu Ala Trp Leu Glu Lys Glu Trp Ser Leu Pro Ser Asp Val Ala
370 375 380
Glu Ala Val Ala Asn Ala His Leu Pro Asp Gly His Gly Arg Phe Gly
385 390 395 400
Leu Thr Ala Thr Val Arg Leu Leu Glu His Leu Lys Ala Asp Val Val
405 410 415
Thr Tyr Ala Glu Ala Ala Arg Arg Ala Gly Phe His His Ser Asp Phe
420 425 430
Arg Asp Gly Ala Cys Tyr Asp Glu Leu Pro Tyr Tyr Gly Glu Ile Leu
435 440 445
Ser Arg Glu Ile Ala Pro Gly Lys Asp Glu Tyr Gly Asp Pro Leu Glu
450 455 460
Arg Gln Trp Gly Lys Ile Thr Asn Pro Thr Val His Ile Gly Leu Asn
465 470 475 480
Gln Leu Arg Arg Leu Ile Asn Ala Leu Val Arg Arg His Gly Arg Pro
485 490 495
Asp Phe Ile Phe Val Glu Leu Ala Arg Glu Leu Lys Leu Asn Glu Lys
500 505 510
Gln Lys Ala Asp His Lys Arg Arg Ile Lys Gln Thr Thr Asp Ala Ala
515 520 525
Arg Ala Arg Ala Glu Lys Leu Arg Glu Ile Gly Gln Arg Asp Ser Gly
530 535 540
Ser Asn Arg Met Leu Leu Arg Ile Trp Glu Glu Leu Asn Pro Ser Asn
545 550 555 560
Pro Leu Asp Arg Arg Cys Pro Tyr Cys Ala Glu Pro Ile Ser Ile Glu
565 570 575
Met Leu Met Ser Gly Ser Ala Asp Ile Asp His Ile Val Pro Tyr Ser
580 585 590
Arg Cys Leu Asp Asp Ser Ala Ala Asn Lys Val Val Ala His Asn His
595 600 605
Cys Asn Arg Gln Lys Gly Asn Arg Thr Pro Trp Glu Gln Trp Gly Gln
610 615 620
Thr Thr Arg Trp Pro Leu Ile Gln Glu Gln Val Ala Arg Met His Arg
625 630 635 640
Ser Lys Gln Trp Arg Phe Gly Pro Asp Ala Met Glu Arg Val Asp Arg
645 650 655
Asp Gly Gly Phe Ile Ala Arg Gln Leu Thr Asp Thr Gln Tyr Leu Ser
660 665 670
Arg Ile Ala Ala Gln Tyr Leu Ser Ala Leu Tyr Thr Pro Asp Glu Gly
675 680 685
Arg Arg Val Tyr Ala Val Thr Gly Arg Leu Thr Ala Met Leu Arg Arg
690 695 700
Leu Trp Gly Leu Asn Asp Ile Leu Pro Asp His Asn Trp Val Leu Asn
705 710 715 720
Pro His Ser Asn Ala Pro Lys Asn Arg Leu Asp His Arg His His Ala
725 730 735
Ile Asp Ala Ala Val Val Gly Ala Thr Thr Pro Ala Met Ile Gln Gln
740 745 750
Val Ala Arg Ala Ala Ala Arg Ala Glu Glu Gln Asp Leu Asp Arg Leu
755 760 765
Phe Ala Asp Leu Pro Pro Pro Trp Pro Gly Phe Arg Glu Glu Leu Gln
770 775 780
Gly Arg Ile Met Ala Ala Val Val Ser His Lys Pro Asp His Gly Arg
785 790 795 800
Lys Gly Arg Pro Leu Pro Gly Arg Asp Ser Thr Ser Gly Arg Leu His
805 810 815
Asn Asp Thr Ala Tyr Gly Phe Thr Gly Arg Arg Asn Ala Lys Gly Met
820 825 830
Pro Ile Val Val Thr Arg Lys Pro Leu Leu Ala Leu Lys Pro Glu Asp
835 840 845
Leu Thr Asp Pro Glu Arg Ile Pro Asp Pro Ala Leu Gln Gly Ala Leu
850 855 860
Phe Glu Ala Thr Arg Gly Ala Thr Gly Lys Asp Phe Glu Lys Ala Leu
865 870 875 880
Arg Asp Phe Ser Arg Arg Asp Gly Pro Tyr Gln Gly Ile Arg Arg Ile
885 890 895
Arg Leu Thr Glu Ala Leu Asn Val Ile Pro Ile Arg Asp Arg Thr Gly
900 905 910
His Ala Tyr Lys Gly Val Lys Gly Asp Ala Asn Ala Arg Phe Asp Val
915 920 925
Trp Arg Leu Pro Asp Gly Lys Trp Ile Thr Arg Trp Lys Asp Arg Asp
930 935 940
Gly Ile Glu His Ser Gly Ile Val Ser Leu Phe Asp Ala His Gln Pro
945 950 955 960
Ser Gln Val Tyr His Arg Pro His Pro Ala Ala Lys Lys Val Leu Ser
965 970 975
Leu Arg Gln Asn Asp Leu Val Ala Val Glu His Asp Gly Asp Pro Gly
980 985 990
Lys Ile Met Arg Val Val Lys Phe Ser Ala Asn Gly Ser Ile Thr Phe
995 1000 1005
Ala Pro His Asn Glu Ala Gly Pro Leu Lys Thr Arg Asp Thr Asp
1010 1015 1020
Pro Ala Asp Pro Phe Arg Tyr Val Thr Thr Val Ala Ser Gly Leu
1025 1030 1035
Lys Lys Met Arg Ala Arg Gln Val Arg Ile Asp Glu Leu Gly Lys
1040 1045 1050
Val His Asp Pro Gly Pro Arg Glu Asp
1055 1060
<210> 7056
<211> 1062
<212> PRT
<213> Artificial Sequence
<220>
<223> OMNI-79 V5570 CRISPR Nuclease
<400> 7056
Met Glu Lys Arg Leu Gly Leu Asp Ile Gly Thr Asn Ser Leu Gly Trp
1 5 10 15
Cys Leu Tyr Glu Gly Asp Ser Ile Leu Asp Ile Gly Val Arg Ile Phe
20 25 30
Ser Asp Gly Arg Asp Pro Lys Ser Gly Ala Ser Leu Ala Val Asp Arg
35 40 45
Arg Asn Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Tyr Leu Gly Arg
50 55 60
Arg Ser Ala Leu Ile Lys Ala Leu Lys Ala His Gly Leu Phe Pro Ala
65 70 75 80
Glu Gln Asp Ala Ala Lys Ala Leu Glu Arg Glu Asp Pro Tyr Ser Leu
85 90 95
Arg Val Arg Ala Leu Asp His Arg Leu Asp Pro His Gln Ile Gly Arg
100 105 110
Ala Ile Phe His Leu Asn Gln Arg Arg Gly Phe Arg Ser Asn Arg Lys
115 120 125
Ala Asp Arg Val Leu Gly Asp Gln Glu Ser Gly Leu Ile Ser Thr Ala
130 135 140
Thr Arg Val Leu Asp Glu Ala Met Ala Lys Ser Gly Ala Arg Thr Leu
145 150 155 160
Gly Glu Phe Leu Ala Ser Arg Asp Thr Arg Arg Val Arg Met Arg Pro
165 170 175
Asp Val Lys Gly Tyr Asp Phe Tyr Pro Asn Arg Gln His Tyr Leu Glu
180 185 190
Glu Phe Glu Lys Ile Trp Asp Ala Gln Ser Gln Tyr His Pro Asp Leu
195 200 205
Leu Ser Gln Gln Ala Lys Ser Ala Ile His Arg Ile Ile Phe His Gln
210 215 220
Arg Pro Leu Lys Pro Gln Ala Val Gly Thr Cys Thr Phe Ala Gly Leu
225 230 235 240
His Gly Ile Pro Gly Asp Glu Thr Arg Leu Pro Lys Ala His Pro Leu
245 250 255
Phe Gln Gln Arg Arg Leu Tyr Glu Glu Val Asn Gln Leu Glu Ile Val
260 265 270
Cys Ala Ser Ala Pro Ala Arg Lys Leu Thr Arg Asp Glu Arg Asp Ala
275 280 285
Leu Ile Leu Lys Leu Gln Asp Lys Lys Lys Val Thr Phe Ser Thr Leu
290 295 300
Ala Arg Thr Ile Arg Leu Lys Glu Gly Glu Arg Phe Asn Lys Glu Ser
305 310 315 320
Glu Asn Arg Lys Asp Leu Ala Gly Asp Glu Val Arg Ala Glu Met Ser
325 330 335
Asp Lys Thr Arg Phe Gly Arg Arg Trp Phe His Leu Ser Leu Asp Glu
340 345 350
Gln Trp Ser Val Ile Asp Arg Leu Leu Asn Glu Glu Ser Thr Glu Asp
355 360 365
Leu Leu Ala Trp Leu Glu Lys Glu Trp Ser Leu Pro Ser Asp Val Ala
370 375 380
Glu Ala Val Ala Asn Ala His Leu Pro Asp Gly His Gly Arg Phe Gly
385 390 395 400
Leu Thr Ala Thr Val Arg Leu Leu Glu His Leu Lys Ala Asp Val Val
405 410 415
Thr Tyr Ala Glu Ala Ala Arg Arg Ala Gly Phe His His Ser Asp Phe
420 425 430
Arg Asp Gly Ala Cys Tyr Asp Glu Leu Pro Tyr Tyr Gly Glu Ile Leu
435 440 445
Ser Arg Glu Ile Ala Pro Gly Lys Asp Glu Tyr Gly Asp Pro Leu Glu
450 455 460
Arg Gln Trp Gly Lys Ile Thr Asn Pro Thr Val His Ile Gly Leu Asn
465 470 475 480
Gln Leu Arg Arg Leu Ile Asn Ala Leu Val Arg Arg His Gly Arg Pro
485 490 495
Asp Phe Ile Phe Val Glu Leu Ala Arg Glu Leu Lys Leu Asn Glu Lys
500 505 510
Gln Lys Ala Asp His Lys Arg Arg Ile Lys Gln Thr Thr Asp Ala Ala
515 520 525
Arg Ala Arg Ala Glu Lys Leu Arg Glu Ile Gly Gln Arg Asp Ser Gly
530 535 540
Ser Asn Arg Met Leu Leu Arg Ile Trp Glu Glu Leu Asn Pro Ser Asn
545 550 555 560
Pro Leu Asp Arg Arg Cys Pro Tyr Cys Ala Glu Pro Ile Ser Ile Glu
565 570 575
Met Leu Met Ser Gly Ser Ala Asp Ile Asp His Ile Val Pro Tyr Ser
580 585 590
Arg Cys Leu Asp Asp Ser Ala Ala Asn Lys Val Val Ala His Asn His
595 600 605
Cys Asn Arg Gln Lys Gly Asn Arg Thr Pro Trp Glu Gln Trp Gly Gln
610 615 620
Thr Thr Arg Trp Pro Leu Ile Gln Glu Gln Val Ala Arg Met His Arg
625 630 635 640
Ser Lys Gln Trp Arg Phe Gly Pro Asp Ala Met Glu Arg Val Asp Arg
645 650 655
Asp Gly Gly Phe Ile Ala Arg Gln Leu Thr Asp Thr Gln Tyr Leu Ser
660 665 670
Arg Ile Ala Ala Gln Tyr Leu Ser Ala Leu Tyr Thr Pro Asp Glu Gly
675 680 685
Arg Arg Val Tyr Ala Val Thr Gly Arg Leu Thr Ala Met Leu Arg Arg
690 695 700
Leu Trp Gly Leu Asn Asp Ile Leu Pro Asp His Asn Trp Val Leu Asn
705 710 715 720
Pro His Ser Asn Ala Pro Lys Asn Arg Leu Asp His Arg His His Ala
725 730 735
Ile Asp Ala Ala Val Val Gly Ala Thr Thr Pro Ala Met Ile Gln Gln
740 745 750
Val Ala Arg Ala Ala Ala Arg Ala Glu Glu Gln Asp Leu Asp Arg Leu
755 760 765
Phe Ala Asp Leu Pro Pro Pro Trp Pro Gly Phe Arg Glu Glu Leu Gln
770 775 780
Gly Arg Ile Met Ala Ala Val Val Ser His Lys Pro Asp His Gly Arg
785 790 795 800
Lys Gly Arg Pro Leu Pro Gly Arg Asp Ser Thr Ser Gly Arg Leu His
805 810 815
Asn Asp Thr Ala Tyr Gly Phe Thr Gly Arg Arg Asn Ala Lys Gly Met
820 825 830
Pro Ile Val Val Thr Arg Lys Pro Leu Leu Ala Leu Lys Pro Glu Asp
835 840 845
Leu Thr Asp Pro Glu Arg Ile Pro Asp Pro Ala Leu Gln Gly Ala Leu
850 855 860
Phe Glu Ala Thr Arg Gly Ala Thr Gly Lys Asp Phe Glu Lys Ala Leu
865 870 875 880
Arg Asp Phe Ser Arg Arg Asp Gly Pro Tyr Gln Gly Ile Arg Arg Ile
885 890 895
Arg Leu Thr Glu Ala Leu Asn Val Ile Pro Ile Arg Asp Arg Thr Gly
900 905 910
His Ala Tyr Lys Gly Val Lys Gly Asp Ala Asn Ala Arg Phe Asp Val
915 920 925
Trp Arg Leu Pro Asp Gly Lys Trp Ile Thr Arg Trp Lys Asp Arg Asp
930 935 940
Gly Ile Glu His Ser Gly Ile Val Ser Leu Phe Asp Ala His Gln Pro
945 950 955 960
Ser Gln Val Tyr His Arg Pro His Pro Ala Ala Lys Lys Val Leu Ser
965 970 975
Leu Arg Gln Asn Asp Leu Val Ala Val Glu His Asp Gly Asp Pro Gly
980 985 990
Lys Ile Met Arg Val Val Lys Phe Ser Ala Asn Gly Arg Ile Thr Phe
995 1000 1005
Ala Pro His Asn Glu Ala Gly Pro Leu Lys Thr Arg Asp Thr Asp
1010 1015 1020
Pro Ala Asp Pro Phe Arg Tyr Val Thr Thr Val Ala Ser Gly Leu
1025 1030 1035
Lys Lys Met Arg Ala Arg Gln Val Arg Ile Asp Glu Leu Gly Lys
1040 1045 1050
Val His Asp Pro Gly Pro Arg Glu Asp
1055 1060
<210> 7057
<211> 1370
<212> PRT
<213> Ezakiella peruensis strain M6.X2
<400> 7057
Met Thr Lys Val Lys Asp Tyr Tyr Ile Gly Leu Asp Ile Gly Thr Ser
1 5 10 15
Ser Val Gly Trp Ala Val Thr Asp Glu Ala Tyr Asn Val Leu Lys Phe
20 25 30
Asn Ser Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr
35 40 45
Ala Glu Glu Arg Arg Gly Gln Arg Gly Ala Arg Arg Arg Leu Asp Arg
50 55 60
Lys Lys Glu Arg Leu Ser Leu Leu Gln Asp Phe Phe Ala Glu Glu Val
65 70 75 80
Ala Lys Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu
85 90 95
Tyr Met Glu Asp Lys Asp Gln Lys Leu Lys Ser Lys Tyr Thr Leu Phe
100 105 110
Asn Asp Lys Asp Phe Lys Asp Lys Asn Phe His Lys Lys Tyr Pro Thr
115 120 125
Ile His His Leu Leu Met Asp Leu Ile Glu Asp Asp Ser Lys Lys Asp
130 135 140
Ile Arg Leu Val Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly
145 150 155 160
His Phe Ile Phe Glu Gly Gln Lys Phe Asp Thr Lys Ser Ser Phe Glu
165 170 175
Asn Ser Leu Asn Glu Leu Lys Val His Leu Asn Asp Glu Tyr Gly Leu
180 185 190
Asp Leu Glu Phe Asp Asn Glu Asn Leu Ile Asn Ile Leu Thr Asp Pro
195 200 205
Lys Leu Asn Lys Thr Ala Lys Lys Lys Glu Leu Lys Ser Val Ile Gly
210 215 220
Asp Thr Lys Phe Leu Lys Ala Val Ser Ala Ile Met Ile Gly Ser Ser
225 230 235 240
Gln Lys Leu Val Asp Leu Phe Glu Asn Pro Glu Asp Phe Asp Asp Ser
245 250 255
Ala Ile Lys Ser Val Asp Phe Ser Thr Thr Ser Phe Asp Asp Lys Tyr
260 265 270
Ser Asp Tyr Glu Leu Ala Leu Gly Asp Lys Ile Ala Leu Val Asn Ile
275 280 285
Leu Lys Glu Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Glu
290 295 300
Ala Asp Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Asn Ala Phe Val
305 310 315 320
Lys Lys Tyr Asn Lys His Gly Gln Asp Leu Lys Glu Phe Lys Arg Leu
325 330 335
Val Arg Gln Tyr His Lys Ser Ala Tyr Phe Asp Ile Phe Arg Ser Glu
340 345 350
Lys Val Asn Asp Asn Tyr Val Ser Tyr Thr Lys Ser Ser Ile Ser Asn
355 360 365
Asn Lys Arg Val Lys Ala Asn Lys Phe Thr Asp Gln Glu Ala Phe Tyr
370 375 380
Lys Phe Ala Lys Lys His Leu Glu Thr Ile Lys Tyr Lys Ile Asn Lys
385 390 395 400
Val Asn Gly Ser Lys Ala Asp Leu Glu Leu Ile Asp Gly Met Leu Arg
405 410 415
Asp Met Glu Phe Lys Asn Phe Met Pro Lys Ile Lys Ser Ser Asp Asn
420 425 430
Gly Val Ile Pro Tyr Gln Leu Lys Leu Met Glu Leu Asn Lys Ile Leu
435 440 445
Glu Asn Gln Ser Lys His His Glu Phe Leu Asn Val Ser Asp Glu Tyr
450 455 460
Gly Ser Val Cys Asp Lys Ile Ala Ser Ile Met Glu Phe Arg Ile Pro
465 470 475 480
Tyr Tyr Val Gly Pro Leu Asn Pro Asn Ser Lys Tyr Ala Trp Ile Lys
485 490 495
Lys Gln Lys Asp Ser Glu Ile Thr Pro Trp Asn Phe Lys Asp Val Val
500 505 510
Asp Leu Asp Ser Ser Arg Glu Glu Phe Ile Asp Ser Leu Ile Gly Arg
515 520 525
Cys Thr Tyr Leu Lys Asp Glu Lys Val Leu Pro Lys Ala Ser Leu Leu
530 535 540
Tyr Asn Glu Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn
545 550 555 560
Asp Leu Pro Ile Thr Glu Glu Met Lys Lys Lys Ile Phe Asp Gln Leu
565 570 575
Phe Lys Thr Arg Lys Lys Val Thr Leu Lys Ala Val Ala Asn Leu Leu
580 585 590
Lys Lys Glu Phe Asn Ile Asn Gly Glu Ile Leu Leu Ser Gly Thr Asp
595 600 605
Gly Asp Phe Lys Gln Gly Leu Asn Ser Tyr Asn Asp Phe Lys Ala Ile
610 615 620
Val Gly Asp Lys Val Asp Ser Asp Asp Tyr Arg Asp Lys Ile Glu Glu
625 630 635 640
Ile Ile Lys Leu Ile Val Leu Tyr Gly Asp Asp Lys Ser Tyr Leu Gln
645 650 655
Lys Lys Ile Lys Ala Gly Tyr Gly Lys Tyr Phe Thr Asp Ser Glu Ile
660 665 670
Lys Lys Met Ala Gly Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys
675 680 685
Lys Leu Leu Thr Gly Leu Glu Gly Ala Asn Lys Ile Thr Gly Glu Arg
690 695 700
Gly Ser Ile Ile His Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu
705 710 715 720
Leu Met Ser Ala Ser Phe Thr Phe Thr Glu Glu Ile Gln Lys Leu Asn
725 730 735
Pro Val Asp Asp Arg Lys Leu Ser Tyr Glu Met Val Asp Glu Leu Tyr
740 745 750
Leu Ser Pro Ser Val Lys Arg Met Leu Trp Gln Ser Leu Arg Ile Val
755 760 765
Asp Glu Ile Lys Asn Ile Met Gly Thr Asp Ser Lys Lys Ile Phe Ile
770 775 780
Glu Met Ala Arg Gly Lys Glu Glu Val Lys Ala Arg Lys Glu Ser Arg
785 790 795 800
Lys Asn Gln Leu Leu Lys Phe Tyr Lys Asp Gly Lys Lys Ala Phe Ile
805 810 815
Ser Glu Ile Gly Glu Glu Arg Tyr Ser Tyr Leu Leu Ser Glu Ile Glu
820 825 830
Gly Glu Glu Glu Asn Lys Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr
835 840 845
Thr Gln Leu Gly Arg Cys Met Tyr Ser Leu Glu Pro Ile Asp Ile Ser
850 855 860
Glu Leu Ser Ser Lys Asn Ile Tyr Asp Gln Asp His Ile Tyr Pro Lys
865 870 875 880
Ser Lys Ile Tyr Asp Asp Ser Ile Glu Asn Arg Val Leu Val Lys Lys
885 890 895
Asp Leu Asn Ser Lys Lys Gly Asn Ser Tyr Pro Ile Pro Asp Glu Ile
900 905 910
Leu Asn Lys Asn Cys Tyr Ala Tyr Trp Lys Ile Leu Tyr Asp Lys Gly
915 920 925
Leu Ile Gly Gln Lys Lys Tyr Thr Arg Leu Thr Arg Arg Thr Gly Phe
930 935 940
Thr Asp Asp Glu Leu Val Gln Phe Ile Ser Arg Gln Ile Val Glu Thr
945 950 955 960
Arg Gln Ala Thr Lys Glu Thr Ala Asn Leu Leu Lys Thr Ile Cys Lys
965 970 975
Asn Ser Glu Ile Val Tyr Ser Lys Ala Glu Asn Ala Ser Arg Phe Arg
980 985 990
Gln Glu Phe Asp Ile Val Lys Cys Arg Ala Val Asn Asp Leu His His
995 1000 1005
Met His Asp Ala Tyr Ile Asn Ile Ile Val Gly Asn Val Tyr Asn
1010 1015 1020
Thr Lys Phe Thr Lys Asp Pro Met Asn Phe Val Lys Lys Gln Glu
1025 1030 1035
Lys Ala Arg Ser Tyr Asn Leu Glu Asn Met Phe Lys Tyr Asp Val
1040 1045 1050
Lys Arg Gly Gly Tyr Thr Ala Trp Ile Ala Asp Asp Glu Lys Gly
1055 1060 1065
Thr Val Lys Asn Ala Ser Ile Lys Arg Ile Arg Lys Glu Leu Glu
1070 1075 1080
Gly Thr Asn Tyr Arg Phe Thr Arg Met Asn Tyr Ile Glu Ser Gly
1085 1090 1095
Ala Leu Phe Asn Ala Thr Leu Gln Arg Lys Asn Lys Gly Ser Arg
1100 1105 1110
Pro Leu Lys Asp Lys Gly Pro Lys Ser Ser Ile Glu Lys Tyr Gly
1115 1120 1125
Gly Tyr Thr Asn Ile Asn Lys Ala Cys Phe Ala Val Leu Asp Ile
1130 1135 1140
Lys Ser Lys Asn Lys Ile Glu Arg Lys Leu Met Pro Val Glu Arg
1145 1150 1155
Glu Ile Tyr Ala Lys Gln Lys Asn Asp Lys Lys Leu Ser Asp Glu
1160 1165 1170
Ile Phe Ser Lys Tyr Leu Lys Asp Arg Phe Gly Ile Glu Asp Tyr
1175 1180 1185
Arg Val Val Tyr Pro Val Val Lys Met Arg Thr Leu Leu Lys Ile
1190 1195 1200
Asp Gly Ser Tyr Tyr Phe Ile Thr Gly Gly Ser Asp Lys Thr Leu
1205 1210 1215
Glu Leu Arg Ser Ala Leu Gln Leu Ile Leu Pro Lys Lys Asn Glu
1220 1225 1230
Trp Ala Ile Lys Gln Ile Asp Lys Ser Ser Glu Asn Asp Tyr Leu
1235 1240 1245
Thr Ile Glu Arg Ile Gln Asp Leu Thr Glu Glu Leu Val Tyr Asn
1250 1255 1260
Thr Phe Asp Ile Ile Val Asn Lys Phe Lys Thr Ser Val Phe Lys
1265 1270 1275
Lys Ser Phe Leu Asn Leu Phe Gln Asp Asp Lys Ile Glu Asn Ile
1280 1285 1290
Asp Phe Lys Phe Lys Ser Met Asp Phe Lys Glu Lys Cys Lys Thr
1295 1300 1305
Leu Leu Met Leu Val Lys Ala Ile Arg Ala Ser Gly Val Arg Gln
1310 1315 1320
Asp Leu Lys Ser Ile Asp Leu Lys Ser Asp Tyr Gly Arg Leu Ser
1325 1330 1335
Ser Lys Thr Asn Asn Ile Gly Asn Tyr Gln Glu Phe Lys Ile Ile
1340 1345 1350
Asn Gln Ser Ile Thr Gly Leu Phe Glu Asn Glu Val Asp Leu Leu
1355 1360 1365
Lys Leu
1370
<210> 7058
<211> 80
<212> RNA
<213> Artificial Sequence
<220>
<223> OMNI-79 sgRNA Scaffold
<400> 7058
guugccgcug gagaaaucca guuguuaaca agcagcuuga cugcaccaaa uaaggcgggg 60
gcugcggccc ucgcuuuuuu 80
<210> 7059
<211> 112
<212> RNA
<213> Artificial Sequence
<220>
<223> OMNI-50 sgRNA Scaffold
<400> 7059
guuugagagu uauguaagaa auuacaugac gaguucaaau aaaaauuuau ucaaaccgcc 60
uauuuauagg ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu 112
Claims (26)
- C3 (Complement component 3) 유전자의 대립유전자를 세포에서 변형시키는 방법으로서, 상기 방법은
적어도 하나의 CRISPR 뉴클레아제 또는 CRISPR 뉴클레아제를 코딩하는 뉴클레오티드 서열; 및
17 내지 50개의 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자, 또는 이를 코딩하는 뉴클레오티드 서열을 포함하는 조성물을 상기 세포에 투여하는 단계를 포함하고,
상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체가 상기 C3 유전자의 대립유전자의 이중가닥 절단을 생성하는 것인 방법. - 청구항 1에 있어서, 상기 조성물은 도입되는 뉴클레오티드 서열의 발현이 상기 C3 유전자의 프로모터에 의해 매개되도록 상기 이중가닥 절단 부위에 도입되는 뉴클레오티드 서열을 포함하는 공여체 분자를 더 포함하는 것인 방법.
- 청구항 2에 있어서, 상기 도입되는 서열은 ATP7B, A1AT, G6PC, SERPINA, LDLR, TTR, 오르니틴 트랜스카르바밀라아제, 아르기니노숙신산 합성효소, 아르기나아제, 아르기니노숙시나아제, 카르바모일 포스페이트 합성효소, N-아세틸글루타메이트 합성효소, 알파 갈락토시다아제 A, 응고 인자 IX, 응고 인자 VII, 리소좀 알파 글루코시다아제, 피브리노겐, 페닐알라닌 4 히드록실라아제, 알칼리 포스파타아제, 글루코실세라미다아제, 베타 갈락토시다아제, 포르포빌리노겐 데아미나아제, 아릴술파타아제 B, 베타 글루쿠로니다아제, 알파 N 아세틸글루코사미니다아제, 리소좀 알파(Lysosomal Alpha), 알파 L-이두로니다아제, 만노시다아제, 포스파티딜콜린 스테롤 아실트랜스퍼라아제, N-술포글루코사민 술포히드롤라아제, 응고 인자 X, N-아세틸갈락토사민-6-술파타아제, 스핑고미엘린 포스포디에스테라아제, A1AT, 이두로네이트-2-술파타아제, 리소좀 알파 글루코시다아제, CDKL5(Cylcin Dependent Kinase Like 5), 프로-LRP1(Prolow Density Liporotein Receptor Related Protein 1), 페닐알라닌 암모니아 리아제, 단백질 글루타민 감마 글루타밀트랜스퍼라아제 K, 또는 리소좀 보호 단백질(Lysosome Protective Protein) 코딩 유전자로부터의 서열인 것인 방법.
- 청구항 1 내지 3 중 어느 한 항에 있어서, 상기 RNA 분자의 가이드 서열 부분은 상기 CRISPR 뉴클레아제를 C3 대립유전자의 SNP 위치로 표적화하는 것인 방법.
- 청구항 4에 있어서, 상기 SNP 위치는 rs17030, rs199713383, 및 rs35473940 중 어느 하나인 것인 방법.
- 청구항 1 내지 5 중 어느 한 항에 있어서, 상기 RNA 분자의 가이드 서열 부분은 C3 대립유전자의 SNP 위치를 표적으로 하는 서열번호 1 내지 7,046 중 어느 하나에 기재된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 포함하는 것인 방법.
- 청구항 4 내지 6 중 어느 한 항에 있어서, 상기 SNP 위치는 이형접합성 SNP를 포함하는 것인 방법.
- 청구항 1 내지 3 중 어느 한 항에 있어서, 상기 RNA 분자는 C3의 인트론 1 또는 C3의 3' 비번역 영역(3' UTR)을 표적으로 하는 비차별적 가이드 서열 부분을 포함하는 것인 방법.
- 청구항 1 내지 3 중 어느 한 항에 있어서, 상기 RNA 분자는 19:6677732-6677881 및 19:6719404-6720515 중 어느 하나로부터 선택된 게놈 범위 내에 위치하는 서열을 표적으로 하는 비차별적 가이드 부분을 포함하는 것인 방법.
- 청구항 1에 있어서, 상기 RNA 분자의 가이드 서열 부분은 서열번호 1 내지 7,046 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 포함하는 것인 방법.
- 청구항 1에 있어서, 상기 RNA 분자의 가이드 서열 부분은 완전 상보적인 C3 표적 서열 대비 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하는 것인 방법.
- 청구항 1에 있어서, 상기 RNA 분자의 가이드 서열 부분은 완전 상보적인 C3 표적 서열 대비 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1 내지 7,046 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 포함하는 것인 방법.
- 청구항 11 또는 12에 있어서, 상기 가이드 서열 부분은 상기 C3 유전자의 대립유전자에 대해 더 높은 상보성을 갖는 가이드 서열 부분에 비해 상기 CRISPR 뉴클레아제와 상기 RNA 분자의 복합체에 대한 더 높은 표적화 특이성을 제공하는 것인 방법.
- 청구항 1 내지 13 중 어느 한 항의 방법에 의해 수득된 변형된 세포.
- 청구항 14에 있어서, 상기 변형된 세포는 줄기세포, 간세포(liver cell), 헤파토사이트(hepatocyte) 또는 iPS-유래 헤파토사이트인 것인 방법.
- 서열번호 1 내지 7,046, 또는 완전 상보적인 C3 표적 서열 대비 1, 2, 3, 4 또는 5개의 뉴클레오티드 불일치를 포함하도록 변형된 서열번호 1 내지 7,046 중 어느 하나에 제시된 서열의 뉴클레오티드를 포함하는 17 내지 50개의 연속 뉴클레오티드를 갖는 가이드 서열 부분을 포함하는 RNA 분자.
- 청구항 16의 RNA 분자 및 적어도 하나의 CRISPR 뉴클레아제를 포함하는 조성물.
- 청구항 17에 있어서, 공여체 분자를 추가로 포함하는 것인 조성물.
- 청구항 18에 있어서, 상기 공여체 분자는 ATP7B, A1AT, G6PC, SERPINA, LDLR, TTR, 오르니틴 트랜스카르바밀라아제, 아르기니노숙신산 합성효소, 아르기나아제, 아르기니노숙시나아제, 카르바모일 포스페이트 합성효소, N-아세틸글루타메이트 합성효소, 알파 갈락토시다아제 A, 응고 인자 IX, 응고 인자 VII, 리소좀 알파 글루코시다아제, 피브리노겐, 페닐알라닌 4 히드록실라아제, 알칼리 포스파타아제, 글루코실세라미다아제, 베타 갈락토시다아제, 포르포빌리노겐 데아미나아제, 아릴술파타아제 B, 베타 글루쿠로니다아제, 알파 N 아세틸글루코사미니다아제, 리소좀 알파(Lysosomal Alpha), 알파 L-이두로니다아제, 만노시다아제, 포스파티딜콜린 스테롤 아실트랜스퍼라아제, N-술포글루코사민 술포히드롤라아제, 응고 인자 X, N-아세틸갈락토사민-6-술파타아제, 스핑고미엘린 포스포디에스테라아제, A1AT, 이두로네이트-2-술파타아제, 리소좀 알파 글루코시다아제, CDKL5(Cylcin Dependent Kinase Like 5), 프로-LRP1(Prolow Density Liporotein Receptor Related Protein 1), 페닐알라닌 암모니아 리아제, 단백질 글루타민 감마 글루타밀트랜스퍼라아제 K, 또는 리소좀 보호 단백질 코딩 유전자로부터의 서열을 포함하는 것인 조성물.
- 청구항 17 내지 19 중 어느 한 항의 조성물을 세포에 전달하는 단계를 포함하는, 세포에서 C3 대립유전자를 변형시키는 방법.
- 청구항 17 내지 19 중 어느 한 항의 조성물을 장애를 갖는 개체의 세포에 전달하거나, 청구항 14 내지 15의 변형된 세포를 상기 개체에 전달하는 단계를 포함하는, 장애를 치료하는 방법.
- 세포에서 C3 대립유전자를 변형시키는데 사용하기 위한 청구항 17 내지 19 중 어느 한 항의 조성물을 포함하는 약제로서, 상기 약제는 청구항 17 내지 19 중 어느 한 항의 조성물을 상기 세포에 전달하는 것에 의해 투여되는 것인 약제.
- 장애를 갖거나 가질 위험이 있는 개체의 세포에 청구항 17 내지 19항 중 어느 한 항의 조성물을 조성물을 전달하거나, 청구항 14 내지 15의 변형된 세포를 상기 개체에게 전달하는 것을 포함하는, 장애를 치료하거나, 개선하거나, 예방하기 위한, 청구항 17 내지 19 중 어느 한 항의 조성물 또는 청구항 14 내지 15의 변형된 세포의 용도.
- 장애를 치료하거나, 개선하거나, 예방하는데 사용하기 위한, 청구항 17 내지 19 중 어느 한 항의 조성물 또는 청구항 14 내지 15의 변형된 세포를 포함하는 약제로서, 상기 약제는 상기 장애를 갖거나 가질 위험이 있는 개체의 세포에 청구항 17 내지 19 중 어느 한 항의 조성물을 전달하거나, 상기 개체에 청구항 14 내지 15의 변형된 세포를 전달하는 것에 의해 투여되는 것인 약제.
- 청구항 21, 23, 또는 24에 있어서, 상기 장애는 간 관련 장애 또는 리소좀 축적 장애인 것인 방법, 용도, 또는 약제.
- 청구항 24에 있어서, 상기 약제는 효소 대체 요법인 것인 약제.
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