KR20240008187A - device for nasal or oral spray for inhibiting virus infection - Google Patents

Abstract

The present invention relates to a spray device, which contains natural nitrite ions (NO2-) produced by microbial fermentation and consists only of a moisturizing stabilizer (HPMC). When reacted with this donor solution, nitrogen oxide is produced by a reduction reaction. It is a two-liquid type nasal that is divided into triggers to quickly generate nitric oxide, stored separately in a two-liquid form, extruded and sprayed, and then the nitric oxide donor solution and the reducing solution can quickly chemically react to generate nitric oxide. Or, it relates to an injection device for oral spray liquid.
Moreover, the present invention improves the performance of the product by fundamentally blocking the chemical reaction of the acidic liquid and the alkaline liquid stored separately from each other during the storage process in the container, and does not leave any residual liquid in the pouch due to the naturally formed reduced pressure state. The usability of raw materials has been increased, and the nasal or oral spray liquid contained in a small spray container is convenient to carry and use, so it can be used at any time before or during use of multiple facilities, minimizing the spread of viruses. Furthermore, it relates to a two-component nasal or oral spray device that has the advantage of being effective not only in preventing colds but also in rhinitis, sinusitis, and inflammatory diseases by supplying a sufficient amount of nitric oxide into the nasal cavity.

Description

Two-component nasal or oral spray device for inhibiting respiratory virus infection {device for nasal or oral spray for inhibiting virus infection}

The present invention relates to a spray device, and more specifically to a two-component nasal or oral spray device that generates nitric oxide to suppress respiratory viral infections.

Specifically, the present invention contains natural nitrite ions (NO2-) produced by microbial fermentation and rapidly generates nitric oxide through a reduction reaction when reacting with the nitric oxide donor functional solution composed only of a moisturizing stabilizer (HPMC). A two-liquid type for suppressing respiratory virus infections that is divided into triggers and stored separately in two-liquid form, and is configured to generate nitric oxide through a rapid chemical reaction between the nitric oxide donor solution and the reducing solution after extrusion spraying. It relates to a nasal or oral spray device.

Diseases that are transmitted through the respiratory tract are transmitted by the virus moving through the air or droplets. Recently, COVID-19, which caused a pandemic, has gradually stabilized and is showing signs of turning into an endemic disease, leading to a large number of people. While biopharmaceutical companies are actively developing 'spray-type' (nebulized) products as simple coronavirus prevention and treatment products, domestic biotech companies are also developing nasal spray Corona prevention and treatment products that are sprayed into the nose. It is being developed in the form of a device.

Previous research and development in response to corona infection was approached as a treatment, but recently, research on its use for preventive purposes is actively underway, and the technology field that is attracting particular attention is a liquid nasal spray that is sprayed into the nose. Research results have been published showing that the viral receptor angiotensin-converting enzyme 2 (ACE2) is distributed mainly in nasal epithelial cells (Non-patent Document 1).

When nasal spray liquid is sprayed into the nasal area (intranasal cavity), gaseous nitric oxide generated around nasal epithelial cells interferes with the binding of the viral spike protein to ACE2 located in the epithelial cell membrane, or super Research has shown that it blocks and inhibits replication of the coronavirus by destroying the DNA of the infectious virus by creating a powerful active nitrogen species called peroxynitrite (ONOO-) combined with oxide (O2-) (Non-patent Document 2).

Since nitric oxide gas inhalation has already been approved as a treatment for the pulmonary artery, many coronavirus treatment hospitals have achieved the result of shortening the treatment period by administering nitric oxide gas to severely ill patients without separate clinical trials. However, it exists as a gas. Complex and huge treatment equipment, which includes a storage container for storing nitric oxide and an electronic control device that finely adjusts it according to the patient's condition, can only be used in large hospitals such as general hospitals, leading to an explosive increase in the number of coronavirus cases. There was a lot of distance between applying it to patients.

Currently, companies developing spray preventive and therapeutic agents in Korea include Genewon Life Science, Salvacion, and SK Bioscience. Genewon Life Science is developing quinine, the main ingredient in 'GLS-1200', which is already on the market as a chronic sinusitis treatment, to protect the nasal mucosa. It was developed as a drug re-creation method using the principle of stimulating the release of nitric oxide, and is currently undergoing phase 2 clinical trials in the United States for the purpose of preventing coronavirus infection.

Salvacion is designed as a mechanism to fundamentally block virus invasion into the human body by fundamentally blocking the binding of the virus to the angiotensin-converting enzyme II (ACE2) receptor by forming a physical protective film over the multiple ciliary layer in the nasal cavity. has proven its safety and effectiveness through clinical trials and has applied for emergency use approval in the U.S. and Europe, and is preparing to apply for sales approval to the Ministry of Food and Drug Safety in Korea. This product is a spray that is sprayed twice daily and is approved by Omicron. It is said to be effective against . They announced that they are in the process of securing protein design technology that can respond to viruses that may arise in the future.

PCT/US2020/027748 was written as a patent on the structural design features of a two-component nasal spray container, but the concentration range and chemical environment are significantly different from the above prior art, even though it is a two-component type claimed in some prior art, and the most important Not only is it not possible to present the chemical conditions of the mixed solution when discharged into the nasal cavity, but the size of the storage container for storing nitric oxide existing as a gas and the equipment for finely controlling it to suit the patient's condition makes it difficult for the general public to easily use it as a portable device. The device or device cannot be presented.

In addition, in relation to the nasal spray device, Korean Patent No. 10-1725713 states that in the nasal spray device for a chemical solution containing a catechin component, a space is formed inside to store a chemical solution containing the catechin component, and the stored chemical solution is rapidly injected. A storage container configured to prevent temperature change, a pump unit configured to discharge the chemical solution from the storage container when a pressing operation is performed, and allow external air to flow in when the pressing operation is released, and a flow path through which air flows into the storage container. A nasal spray device for a medicinal liquid containing a catechin component, including a filter unit disposed to filter incoming air, and a discharge unit provided on the outside of the pump unit and configured to spray the medicinal liquid discharged from the storage container to the outside. It is starting,

Korean Patent No. 10-1809598 discloses a container body with an open top to accommodate liquid inside, and a container body that is coupled to the upper part of the container body and sprays the liquid contained in the container body to the outside by pressing on the upper part. In the spray including an installed pump and a coupling means for connecting the container body and the pump, the container body includes an inner chamber provided with a storage space for accommodating liquid, and surrounds the side and bottom surfaces of the inner chamber and is located inside. Including an external chamber provided with a space, wherein the space blocks heat transmitted from the outside to the storage space to stably store the liquid, and the external chamber includes a sealing means to maintain a vacuum state in the space, The sealing means includes an opening and closing hole provided on the bottom of the external chamber; On the inside, there is a stopper made of synthetic resin or rubber material that has elasticity so that the air in the space can be discharged to the outside and the needle of the syringe can be inserted to create a vacuum state in the space, and that prevents air from flowing in and out, and the opening and closing hole is provided. It is composed of a cover for shielding, and the space portion is provided with a plurality of partition walls at equal intervals radially connected from the side outer peripheral surface of the inner chamber to the inner peripheral surface of the outer wall of the outer chamber to stably support the inner chamber and the outer chamber. A spray equipped with a characterized dual chamber is disclosed.

However, these prior technologies are one-liquid technologies that use simple therapeutic or preventive medicinal solutions, and there are limitations in generating nitric oxide through the chemical reaction of two liquids, and do not present the chemical conditions of the mixed solution when discharged into the nasal cavity. Not only that, but due to the size of the storage container for storing nitric oxide and the equipment to control it, it is not possible to propose a device or device that the general public can easily use as a portable device when necessary.

Patent Document 1: Republic of Korea Patent No. 10-1725713 (2017.04.04) Patent Document 2: Republic of Korea Patent No. 10-1809598 (December 11, 2017) Patent Document 3: PCT/US2020/027748

Non-patent Document 1: Ji Hoon Ahn, JungMo Kim, Seon Pyo Hong et al., Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19, The Journal of Clinical Investigation, Jul. 2021, 131(13):e148517. Non-patent Document 2: Ji HoonAhn, JungMoKim, et al., Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19, The Journal of Clinical Investigation, 2021, 131(13)

The present invention was developed to solve the problems of the prior art as described above, and its purpose is to provide a spray device that is easy to carry and can be used at any time.

In particular, the purpose of the present invention is to provide a spray device that can locally produce a large amount of nitric oxide whenever and wherever necessary, thereby providing antiviral and anti-inflammatory effects to the relevant area.

In more detail, the present invention ejects a nitrogen oxide donor (NO Doner) containing nitrite ions (Nitrite, NO2-), a nitrogen oxide precursor, and this aqueous solution and a reducing agent (NO Trigger) together in the spraying step, thereby instantaneously generating NO. In order to use the gas locally, furthermore, in order to prevent nitrite ions from being oxidized even during long-term storage, the donor and reducing agents are stored separately, and the active ingredient solution is 100% stored so that no residue remains at the bottom of the storage container. It can be used efficiently, and the nitrite ion of the reducing agent is stabilized even during long-term storage and the chemical composition and pH environment of the sprayed mixture are clearly maintained, effectively making it a composition for nasal or oral spray, which is a preventive agent for suppressing respiratory virus infections. The purpose is to provide a two-component nasal or oral spray device that can be used.

The two-component nasal or oral spray device according to the present invention for solving the above object is a spray device that sprays a solution in the form of droplets into the nasal cavity or oral cavity, and a space for storing the nitric oxide reduction solution is formed inside, A storage container in which a space for storing the nitric oxide donor solution is formed separately; A pump unit that discharges or blocks the solution stored in each of the two storage containers by pressure according to the pressing operation; A discharge unit including a pressurizing unit that operates the pump unit, a discharge port that discharges the solution pressurized by the pump unit that operates by driving the pressurizing unit to the outside, and a guide pipe that guides the discharged solution to be sprayed into the nasal cavity. It is characterized by

It is preferable that at least one of the storage containers for storing the nitrogen oxide donor solution and the nitrogen oxide reduction solution use a polymer synthetic resin material having chemical resistance and moisture resistance characteristics. Specifically, polyvinyl chloride (PVC) in the form of a film. , polyethylene (PE), polypropylene (PP), (PC), polyethylene terephthalate (PET), nylon (NY), etc. may be preferable.

More specifically, considering marketability, it is preferable to use an aluminum pouch with vinyl coated on the innermost layer.

In the case of pure aluminum pouches, corrosion does not occur in the nitrogen oxide reducing solution in an acidic environment, but the passivation layer of Al ₂ O ₃ and Al ₃ O ₄ formed on the outermost layer of aluminum gradually dissolves in the nitrogen oxide donor solution in an alkaline environment. Because.

Since the gist of the present invention is to use a flexible, airtight storage method for the discharge pump with chemical and moisture resistance characteristics, the specific material will not be specified, but for detailed explanation, aluminum with a vinyl layer with excellent marketability is used. I will explain the use of the pouch with an example.

The nitrogen oxide donor solution and the reducing solution are preferably designed to be stored separately, sprayed through the discharge port, and then mixed to produce nitrogen oxide gas.

It is preferable that the external storage solution stored outside the pouch is stored at a ratio of 1:1.01 to 1.20 compared to the storage solution stored in the aluminum pouch.

The pump unit preferably stores air introduced from the outside into the outer space of the pouch in proportion to the chemical liquid discharged from the chemical liquid flow path.

The pump unit includes a body part that is separately composed of a nitrogen oxide reduction fluid flow path and a nitrogen oxide donor fluid flow path, and is coupled to the storage container; A cylinder unit provided inside the body unit and supporting a pumping operation for discharging the chemical solution; An opening/closing valve that discharges the nitrogen oxide donor solution and the reducing solution but blocks the backflow of the chemical solution and gas, wherein the chemical solution is sprayed to the outside through the discharge part by a pressing operation of the cylinder unit, and the pressing operation of the cylinder unit is released. In this state, it is desirable that the flow path is blocked by an on-off valve.

The cylinder part preferably includes a cylinder connected to each flow path of the nitrogen oxide donor solution and the reducing solution, a piston that reciprocates inside the cylinder, and a spring that elastically supports the piston.

The discharge portion includes a protrusion and a vortex portion, wherein the protrusion is formed to have a relatively narrow inner diameter compared to the flow path, and the vortex portion preferably includes a blade extending at an angle to the direction of extension of the flow path so that the chemical liquid passes through and forms a vortex. do.

The two-component nasal or oral spray device according to the present invention is easy to carry and has the effect of producing a large amount of nitric oxide locally whenever and wherever needed, thereby providing antiviral and anti-inflammatory effects to the relevant area.

Furthermore, the present invention discharges a nitrogen oxide donor (NO Doner) containing nitrite ions (Nitrite, NO ₂ -), which is a nitrogen oxide precursor, together with this aqueous solution and a reducing agent (NO Trigger) in the spraying step, thereby instantly generating NO gas. It has the effect of allowing it to be used locally.

In particular, the present invention stores the donor and reducing agents separately, thereby preventing nitrite ions from being oxidized even during long-term storage, and not only enables 100% efficient use of the active ingredient solution so that no residue remains at the bottom of the storage container. The nitrite ion of the reducing agent is stabilized even when stored for a long time, and the chemical composition and pH environment of the sprayed mixture are clearly maintained, allowing effective use of the composition for nasal or oral spray, which is a preventive agent for suppressing respiratory viral infections. .

1 is a partial exploded perspective view of a two-component nasal or oral spray device according to the present invention.
Figure 2 is an exploded perspective view of another example of a two-component nasal or oral spray device according to the present invention.
3 is a cross-sectional view of an example of a two-component nasal or oral spray device according to the present invention.
Figure 4 is a cross-sectional view of another example of a two-component nasal or oral spray device according to the present invention.
Figure 5 is a cross-sectional view of the discharge part constituting the two-component nasal or oral spray device according to the present invention

Since the present invention can be implemented with various changes, specific embodiments will be illustrated in the drawings and explained through detailed description. However, this is not intended to limit the present invention to specific embodiments, and should be understood to include all changes, equivalents, and substitutes included in the spirit and technical scope of the present invention.

While describing each drawing, similar reference numerals are used for similar components. In describing the present invention, if it is determined that a detailed description of related known technologies may obscure the gist of the present invention, the detailed description will be omitted.

The present invention is a device that generates nitric oxide to suppress respiratory viral infections and is easy to carry and can be used at any time. As a nitric oxide gas donor, only natural nitrite ions made by microbial fermentation are used as a nitric oxide donor, and as a reducing agent, It is a food raw material that is harmless to the human body and contains an acidity regulator rich in hydrogen ions (H+). The two types are used interchangeably, but these two ingredients are thoroughly separated from each other and stored separately to prevent mutual chemical reactions from occurring when stored in the container. In addition, a reduced pressure condition corresponding to the volume expelled from the storage container is created, so that naturally, there is no air layer in the stored liquid in the storage container (especially the pouch), making it possible to use the entire amount without leaving any residue of the stored liquid.

In addition, one embodiment of the composition used by the two-component nasal or oral spray device according to the present invention converts nitrate, which is abundant in plants, into nitrite by inoculating and fermenting nitrate-reducing bacteria such as Bacillus amiliquipations and Bacillus subtilis. Afterwards, the concentrated fermentation broth is alkalized, hydroxypropyl methylcellulose (HPMC), which has moisturizing and stabilizing effects, is added, and citric acid or ascorbic acid as an acidity regulator is stored separately in an isolated space, and then spray extruded. Spray into the nasal cavity with a droplet spray solution at a 1:1 ratio.

In addition, in a more specific embodiment of the composition for a nasal or oral spray device according to the present invention, a nitric oxide donor (hereinafter referred to as a nitric oxide donor solution) is prepared as a first liquid, and on the other hand, nitrite ions are converted into nitric oxide (NO) gas. In order to reduce and vaporize an acidic solution (nitric oxide reducing solution) with a high hydrogen ion concentration and pH 2.0 to 6.0, the nitrogen oxide donor solution and the reduced solution are stored in a separate space as a second solution. When spraying, the nitrogen oxide donor solution and the reduced solution are 1:1. It is sprayed at the same weight ratio of 1, and when the two liquids are combined, the nitrite ion concentration is sprayed in the range of 500~10,000 ppm and pH 4.0~6.9, generating nitric oxide that can relieve harmful bacteria, viruses, and inflammation in the nasal cavity for a certain period of time. It has a composition that can be

Here, if the pH condition of the nitric oxide reducing solution is strongly acidic, pH 2 or less, the pH of the nitric oxide donating solution becomes too low and the production of nitric oxide increases in a short period of time, resulting in a large amount being released into the air through respiration, shortening the duration of the effect. In addition, strong acids are limited because they can cause damage to nasal cells. In the case of weakly acidic or alkaline pH of 6 or higher, the neutral or alkaline state is maintained when it meets the nitric oxide donor solution in the pH range of 7.0 to 10.0, ultimately resulting in nitrous acid. Since hydrogen ions required for ion reduction are not supplied, it becomes difficult to produce nitric oxide gas, making it difficult to expect its original efficacy.

Hereinafter, an example of a two-component nasal or oral spray device according to the present invention will be described in detail.

The two-component nasal or oral spray device according to the present invention is a spray device that sprays a solution in the form of droplets into the nasal cavity or oral cavity. As shown in Figures 1 to 4, a space is formed inside to store the nitric oxide reduction solution. A storage container (10) in which a space for storing the nitric oxide donor solution is formed separately; A pump unit (20) that discharges or blocks the solution stored in each of the two storage containers by pressure according to the pressing operation; A discharge unit (30) including a pressurizing unit that operates the pump unit, a discharge port that discharges the solution pressurized by the pump unit that operates by driving the pressurizing unit to the outside, and a guide pipe that guides the discharged solution to be sprayed into the nasal cavity. Includes.

The storage container 10 is formed to have a separate space to separately store the nitrogen oxide reduced solution and the nitrogen oxide donor solution, so that the nitrogen oxide reduced solution and the nitrogen oxide donor solution are mixed before being sprayed and converted into nitrogen gas. made it possible to prevent it.

That is, the spray device of the present invention allows the separately stored nitrogen oxide reduction solution and nitrogen oxide donor solution to react with each other to form nitrogen gas after being sprayed.

To this end, it is desirable to store the storage container 10 in a sealed package in a 100% vacuum state to prevent any movement of each chemical liquid between gases.

As described above, if it has a structure that can separately store the nitric oxide reducing solution and the nitric oxide donating solution, it can be modified into any form, but preferably, at least one aluminum pouch can be used as shown in Figure 2. .

That is, all storage containers can be manufactured in the form of pouches as shown in Figures 1 and 3, or only one can be manufactured in the form of a pouch as shown in Figures 2 and 4 and the other can be made of a normal storage container. You can.

Of course, when both storage containers are manufactured in the form of a pouch as shown in Figures 1 and 3, the pouch-shaped storage container is deformed in the process of operating the pump unit to discharge the chemical solution, thereby facilitating the operation of the pump unit. This may not be possible, and in order to solve this disadvantage, an external container (10p) can be additionally installed as shown in FIGS. 1 and 2, and this external container (10p) is configured as shown in FIGS. 2 and 4. If possible, it may be identical and similar to the main storage container (10).

When the storage container is manufactured in the form of a pouch, the pouch shrinks during the process of spraying the stored chemical solution, thereby depressurizing the inside of the pouch, which has the advantage of generating nitric oxide gas by using 100% of the entire amount without leaving any residual liquid in the pouch. .

When using only one type of chemical liquid storage container among the above storage containers as a pouch, the chemical liquid stored inside the pouch is sealed by the pouch and does not evaporate, but the liquid stored outside the pouch may partially evaporate over time. This can be done, and when the external storage solution evaporates, the amount decreases compared to the internal storage solution, so even though the internal storage solution remains, the spray cannot be used due to the lack of the external storage solution.

Accordingly, it is desirable to store the amount of externally stored chemical solution at 1.01 to 1.20 times the amount of internally stored chemical solution stored in the pouch.

In addition, as mentioned above, when using only one pouch among the storage containers and using general storage containers for the rest, or installing an external container outside the two pouches, if the chemical liquid inside the pouch is discharged by the operation of the pump unit, this discharge amount is increased. By allowing air to flow in proportionally only to the outside of the pouch container, all of the chemical solution inside the pouch could be discharged.

The storage container may be formed of various materials and shapes according to required conditions and design specifications, and the present invention is not limited or limited by the material and form of the storage container. Preferably, the storage container may be made of non-toxic synthetic resin, and may also be made of a transparent, translucent or opaque material depending on the required conditions.

The outer container has an opening in the same direction as the pouch, which is the inner container, and is made of a material with strong impact resistance, but may be configured with a double partition.

The pouch (inner container) in which each chemical liquid is stored is spaced apart from the outer container at a predetermined interval, and an insulating space can be formed between the inner and outer walls of the outer container, and the insulating space contains air to improve insulation performance and reduce external shock. can be protected from

Meanwhile, a damping member may be inserted into the insulating space of the external container, and this damping member may be configured to reduce the temperature of the chemical liquid stored inside from rapidly changing in response to external temperature changes.

The damping member may be used by mixing at least one material such as Styrofoam, stone, plastic, or glass wool.

Since the damping member increases the insulation performance of the storage container, it can reduce the rapid temperature change of the chemical solution contained inside the storage container even when a rapid external temperature change occurs, thereby preventing the deterioration of the nitric oxide reducing solution and the nitrogen oxide donating solution. The possibility of this happening can be reduced.

As mentioned above By separating the containers in which each chemical liquid is stored into pouches, airtightness is maintained, preventing direct contact between chemical liquids as well as contact between gases that can occur at high temperatures in the summer. The liquid stored in the pouch has the advantage that a vacuum condition is naturally formed due to the negative pressure load applied each time it is discharged, so there is almost no liquid residue.

The pouch is preferably an aluminum pouch made of aluminum.

The external container may be coupled to the storage container and serve as a cover member. That is, the cover member may be combined with the storage container so as to entirely cover the pump portion at the top of the storage container. This cover member can prevent contamination and damage to the pump unit. The cover member may be made of a transparent or opaque material, and the present invention is not restricted or limited by the shape and structure of the cover member.

The storage container 10 is configured so that the flow paths constituting the pump unit 20 are fitted and combined, and each flow path has the same diameter and pressure.

The pump unit 20 is a means for spraying the chemical liquid stored in each storage container in the form of droplets. When the pressing operation is performed, the chemical liquid is discharged from the storage container, and when the pressing operation is released, external air flows in. The air cannot enter the pouch, which is the inner container, and flows into the outer container in an amount equal to the amount of chemical discharge.

The pump unit 20 may be provided in various structures depending on required conditions and design specifications. For example, it may be configured to include a dispenser that pumps and sprays a chemical solution by pressing the pump unit. In this case, Accordingly, the pump unit may be configured to spray the chemical solution in an automatic or semi-automatic manner.

The pump unit 20 is composed of separate chemical liquid passages, a nitrogen oxide reduction liquid flow channel and a nitrogen oxide donor liquid flow channel.

As shown, the pump unit 20 includes a body unit 21, a cylinder unit 22, and an opening/closing valve 23. Of course, a chemical liquid passage 10w is formed in the pump unit.

The chemical liquid passage 10w is a passage through which the chemical liquid stored in each chemical liquid storage container is discharged to the outside as the pump unit is operated, and is divided into a nitric oxide reduced liquid flow channel and a nitrogen oxide donor liquid flow channel depending on the type of solution stored in the storage container. are installed separately, and are spaced apart from each other even inside the pump unit.

That is, inside the pump unit, the chemical liquid flow paths are separated from each other according to the type of chemical liquid, and the chemical liquid flow paths, the nitric oxide reduced liquid flow channel and the nitrogen oxide donor liquid flow channel, respectively form different flow paths. In particular, the air inflow path and the chemical liquid flow path are formed so as not to interfere with each other, so that the air inflow path and the chemical liquid discharge path as well as the chemical liquid flow path do not overlap each other.

In addition, the pump part is formed to allow external air to flow in, preventing pressure inside the storage container from being applied as a certain amount of air flows into the external container when the chemical solution is discharged.

The body portion 21 forms the external body of the pump unit and has a tubular shape, and has a chemical liquid flow path formed therein. A piston and a spring, which will be described later, are installed in the middle of this chemical liquid flow passage.

In addition, the body part protects the components installed inside the pump part from forces applied from the outside, while a cylinder is formed and the chemical solution is drawn in by the action of a piston installed inside the cylinder.

That is, in the middle of the body part, a cylinder part 22 is integrally formed to support the pumping operation of discharging the chemical solution, and as shown in Figures 3 and 4, this cylinder part 22 contains nitrogen oxide. It includes a cylinder (22c) connected to each flow path of the donor liquid and the reducing liquid, a piston (22p) that reciprocates inside the cylinder, and a spring (22s) that elastically supports the piston.

The cylinder 22c may be a piston reciprocating movement section of the cylinder constituting the body portion or may be installed inside this portion.

The end of the piston 22p is coupled to the discharge part 30, and the pressurizing part 30h constituting the discharge part 30 is coupled to the discharging part, and the piston operates by pressing the pressurizing part to form a storage container. The chemical solution is discharged to the discharge part.

The on-off valve 23 is arranged to open and close each chemical fluid passage connected to the upper part of the cylinder, and its structure and characteristics can be changed in various ways depending on required conditions and design specifications.

The opening/closing valve is provided to be interlocked with the pressurizing part, so that it moves in a straight line when the pressurizing part is pressed, and can selectively open and close the chemical liquid flow path. That is, when the pressurizing part is pressed, the opening/closing valve opens the chemical liquid flow path, and when the pressing operation of the pressurizing part is released, the opening/closing valve blocks the chemical liquid flow path. In other words, when the body part is not pressed, the on-off valve is basically placed in a state of blocking the chemical liquid flow path. At this time, when the body part is pressed down, the on-off valve opens and the stored chemical liquid moves toward the discharge part and then goes out. It is sprayed.

The opening/closing valve may be implemented in various modifications, but one example may be in the form of a ball as shown.

The spring 22s is configured to apply a restoring force to return the piston to its original position as the pressure applied to the pressing portion is released. That is, the spring elastically supports the piston, and the pressing part coupled to the end of the piston is supported so that it can be elastically pressed by the spring, so that when the pressing operation of the pressing part by the user is released, the elastic member The pressing portion may be returned to its initial position by elastic force.

The pressurizing part 30h is a part that is pressed by the user, and may have a handle protruding outward parallel to the bottom of the storage container to facilitate pressurization by the user. When the pressurizing part is pressed, each chemical fluid passage is opened. , the chemical liquid filled by the user's pressing operation can be discharged through the chemical liquid flow path, and when the pressing operation is released, the chemical liquid flow path can be blocked by the opening and closing valve.

When the pressurizing part is not pressed, the chemical fluid flow path may be blocked by the opening/closing valve, thereby preventing external air or contaminants from flowing into the internal storage container through the chemical fluid flow path.

The discharge unit 30 serves to spray the chemical liquid pumped by the pump unit to the outside, and sprays the chemical liquid in the form of droplets.

The discharge part is provided on the outside of the pump unit 20 and is configured to spray the chemical liquid discharged from the storage container to the outside. It is connected to each chemical liquid flow path, and as the pressurizing part is pressurized, the chemical liquid flows out and is discharged to the outside. .

Inside the discharge part, separate channels are formed for the nitric oxide reducing solution and the nitric oxide donating solution to flow, and the discharged chemical solution is not clumped together and is sprayed to the outside in the form of a scattered mist, which is sprayed inside the nasal cavity. The medicinal solution can be easily applied to the mucous membrane inside the nasal cavity.

The protrusion 31 is formed to have a relatively narrow inner diameter compared to the flow path, and the vortex portion 32 includes a blade that extends at an angle to the extension direction of the flow path so that the chemical solution passes through it and forms a vortex.

The discharge unit 30 will be described in detail with reference to FIG. 5 .

As described above, the discharge portion 30 includes at least a protrusion 31 and a vortex portion 32.

The chemical liquid passing through the internal flow path of the discharge part 30 passes through the protrusion 31 and the vortex part 32 and is atomized into finer particles.

The protrusion 31 is formed to protrude from the inner surface of the flow path so that the inner diameter of the flow path becomes narrower. That is, as shown in FIG. 5, the protrusion 31 has a semicircular shape in the longitudinal direction of the flow path from the inner surface of the flow path and protrudes toward the center of the flow path, and its inner diameter is larger than the inner diameter of the flow path into which the chemical liquid flows. It becomes narrow.

As the chemical solution passes through the protrusion 31, it causes rapid changes in speed and pressure. Specifically, since the inner diameter of the protrusion 31 is narrower than the inner diameter of the flow path through which the chemical solution flows ahead of the protrusion 31, the pressure increases and the speed increases due to the Bernoulli effect. During this process, the chemical solution is primarily atomized.

The vortex portion 32 is formed in a flow path through which the chemical liquid flows, and is disposed at the rear of the protrusion 31 so that the chemical liquid can pass through the vortex portion 32 after passing through the protrusion 31 .

The vortex portion 32 includes a wing-shaped blade 32b and a central axis formed integrally with the inner end of the blade 32b. The blade 32b not only extends long in the direction in which the flow path extends, but also extends in the radial direction of the flow path from the central axis and is integrally formed and fixed to the inner surface of the flow path.

The blade 32b is formed in the shape of a wing, and is configured so that the passing chemical solution forms a vortex. Specifically, as the blade 32b extends in the longitudinal direction of the flow path, it bends and extends along the circumferential direction of the flow path. That is, the blade 32b is disposed and extended at an angle with respect to the direction in which the flow path extends.

In more detail, so that the chemical liquid flows along the flow path to form a vortex, the blade 32b is not formed in a straight line as it moves toward the end of the discharge part 30, but in the same direction as the flow path, rather than in the flow direction. It is formed while moving in the circumferential direction of the flow path as it progresses, and the chemical liquid passing through the blade (32b) rotates in a spiral direction along the surface of the blade (32b) to form a vortex.

In addition, the chemical liquid passing through the vortex portion 32 not only forms a vortex, but also passes through the protrusion 31 as described above, and an atomization phenomenon occurs in which the particle size becomes smaller due to the faster flow rate. That is, the chemical liquid passes through the vortex portion 32, forms a vortex, and is atomized secondarily.

Additionally, the discharge unit may further include a nozzle unit 33.

The nozzle portion 33 is formed at the outlet of the discharge portion and is a passage through which the chemical liquid is finally discharged to the outside of the discharge portion 30. The nozzle portion 33 has a larger diameter inside the discharge portion 30 than the end of the discharge portion 30. It is formed small. That is, the diameter of the starting part of the nozzle part 33 based on the flow of the chemical liquid is smaller than the diameter of the ending part of the nozzle part 33.

As shown in FIG. 5, the nozzle portion 33 gradually becomes wider in diameter toward the end of the discharge portion 30. That is, the diameter of the starting part of the nozzle part 33 is very narrow, and the diameter of the nozzle part 33 gradually widens along the extending direction of the nozzle part 33, so the chemical liquid passing through the nozzle part 33 is governed by Bernoulli's law. is released to the outside at a rapid rate. As it passes through the inside of the small-diameter nozzle part 33 and proceeds toward the end of the large-diameter nozzle part 33, the chemical liquid is atomized three times.

In this way, the chemical liquid passes through the protrusion part 31, the vortex part 32, and the nozzle part 33 and goes through a three-stage atomization process. In this process, the chemical solution becomes a fine mist with a particle size of approximately 3 to 10 μm.

Therefore, the nasal or oral spray device for suppressing respiratory virus infection according to an embodiment of the present invention sprays the chemical solution in the size of fine particles through about three atomization processes. Therefore, the chemical solution atomized into fine-sized particles sprayed onto the nasal mucosa can be applied to the nasal mucosa more quickly, and when the nitric oxide reducing solution and the nitric oxide donating solution come in contact with the air, they produce nitric oxide through a mutual chemical reaction for a certain period of time. is produced, and the medicinal effects of nitric oxide can appear more quickly, continuously, and effectively.

The spray device of the present invention configured as described above is provided with a fixing part 11 for coupling the pump part, the discharge part, and the external container to each other, as shown.

As shown in Figures 1 to 4, the fixing part 11 includes a discharge coupling part 11o to which the discharge part is coupled, a pump coupling groove 11p to which the pump part is coupled, and a container coupling part to which the external container is coupled ( Includes 11c).

That is, the pump part is installed through the pump coupling groove (11p), and the end of the piston at one end of the pump part is coupled to the discharge body (30b) constituting the discharge part, so that the pressurizing part (30h) is formed on one side of the discharge body. When pressed, the piston operates.

As shown in Figures 3 and 4, the discharge coupling portion 11o is installed to surround a portion of the outer circumference of the discharge portion.

As shown in Figures 3 and 4, an external container is coupled to the container coupling portion 11c to protect the pump unit installed inside the external container.

The discharge part 30 has a flow path as described above, and the discharge body 30b is integrally formed at the end of the discharge part facing the fixing part.

As shown, the discharge body (30b) has a receiving space formed inside, and a pump coupling plate (30p) is formed in this receiving space, and the pump coupling plate has a hole into which the piston end of each pump is inserted and coupled. This is formed.

The space between the pump coupling plate installed in the space inside the discharge main body and the discharge main body becomes a space where the nitrogen oxide reducing solution and the nitrogen oxide donor solution discharged from the two pump units are mixed.

That is, as shown in Figures 3 and 4, the space between the discharge body and the pump body serves as a mixing space, and the mixed liquid mixed in this space passes through the discharge part and is discharged in an atomized state.

10: Storage container
11: Fixing part
11o: Discharge coupling portion 11p: Pump coupling groove
11c: container joint
20: Pump part
20w: Chemical fluid flow path
21: body part
22: cylinder part 22c: cylinder
22p: Piston 22s: Spring
23: Open/close valve
30: discharge part
30b: Discharge body 30h: Pressurizing part
30p: Pump coupling plate
31: protrusion
32: vortex portion 32b: blade
33: nozzle part

Claims (8)

In a spray device that sprays a solution in the form of droplets into the nasal cavity or oral cavity,
A storage container in which a space for storing the nitric oxide reducing solution is formed and a space for storing the nitric oxide donor solution is formed separately;
A pump unit that discharges or blocks the solution stored in each of the two storage containers by pressure according to the pressing operation;
A discharge unit including a pressurizing unit that operates the pump unit, a discharge port that discharges the solution pressurized by the pump unit that operates by driving the pressurizing unit to the outside, and a guide pipe that guides the discharged solution to be sprayed into the nasal cavity. Features a two-part nasal or oral spray device. According to paragraph 1,
A two-component nasal or oral spray device, wherein at least one of the storage containers for storing the nitric oxide donor solution and the nitric oxide reduced solution is an aluminum pouch. According to paragraph 1,
A two-component nasal or oral spray device characterized in that the nitric oxide donor solution and the reducing solution are stored separately, sprayed through an outlet, and then mixed to produce nitric oxide gas. According to paragraph 2,
A two-component nasal or oral spray device characterized in that the external storage solution stored outside the pouch is stored at a ratio of 1:1.01 to 1.20 compared to the storage solution stored in the aluminum pouch. According to paragraph 1,
The pump unit is a two-component nasal or oral spray device characterized in that air introduced from the outside is stored in the outer space of the pouch in proportion to the chemical liquid discharged from the chemical liquid flow path. According to paragraph 1,
The pump unit is composed of a chemical fluid flow path, a nitrogen oxide reduction fluid flow path, and a nitrogen oxide donor fluid flow path, respectively.
A body portion coupled to the storage container;
A cylinder unit provided inside the body unit and supporting a pumping operation for discharging the chemical solution;
Includes an opening/closing valve that discharges the nitric oxide donor solution and reducing solution but blocks the backflow of the chemical solution and gas;
By pressing the cylinder part, the chemical liquid is sprayed to the outside through the discharge part,
A two-component nasal or oral spray device, characterized in that the flow path is blocked by an on-off valve in a state in which the pressing operation of the cylinder portion is released. According to clause 6,
A two-component nasal cavity or Oral spray device. According to paragraph 1,
The discharge portion includes a protrusion and a vortex portion, wherein the protrusion is formed to have a relatively narrow inner diameter compared to the flow path, and the vortex portion includes a blade extending at an angle to the extending direction of the flow path so that the chemical solution passes through and forms a vortex. A two-component nasal or oral spray device.