KR20240004618A - Ruvc 도메인을 갖는 효소 - Google Patents
Ruvc 도메인을 갖는 효소 Download PDFInfo
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- Enzymes And Modification Thereof (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163182438P | 2021-04-30 | 2021-04-30 | |
| US63/182,438 | 2021-04-30 | ||
| PCT/US2022/027124 WO2022232638A2 (en) | 2021-04-30 | 2022-04-29 | Enzymes with ruvc domains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240004618A true KR20240004618A (ko) | 2024-01-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020237040583A Pending KR20240004618A (ko) | 2021-04-30 | 2022-04-29 | Ruvc 도메인을 갖는 효소 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240110167A1 (https=) |
| EP (1) | EP4330386A4 (https=) |
| JP (1) | JP2024517607A (https=) |
| KR (1) | KR20240004618A (https=) |
| CN (1) | CN117203332A (https=) |
| AU (1) | AU2022264921A1 (https=) |
| BR (1) | BR112023022270A2 (https=) |
| CA (1) | CA3214222A1 (https=) |
| MX (1) | MX2023012606A (https=) |
| WO (1) | WO2022232638A2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3225082A1 (en) | 2021-08-27 | 2023-03-02 | Brian C. Thomas | Enzymes with ruvc domains |
| MX2024006257A (es) | 2021-11-24 | 2024-07-29 | Metagenomi Inc | Sistemas de endonucleasas. |
| AU2024339645A1 (en) * | 2023-09-13 | 2026-04-23 | Metagenomi Therapeutics, Inc. | Engineered and chimeric nucleases |
| WO2025106934A1 (en) * | 2023-11-16 | 2025-05-22 | Metagenomi, Inc. | Enzymes with ruvc domains |
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| CA2894684A1 (en) * | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes |
| US9234213B2 (en) * | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| AU2018240515B2 (en) * | 2017-03-24 | 2024-07-25 | CureVac SE | Nucleic acids encoding CRISPR-associated proteins and uses thereof |
| KR20200124702A (ko) * | 2018-02-23 | 2020-11-03 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 신규한 cas9 오르소로그 |
| AU2020223370B2 (en) * | 2019-02-14 | 2023-04-20 | Metagenomi Therapeutics, Inc. | Enzymes with RuvC domains |
| US10913941B2 (en) * | 2019-02-14 | 2021-02-09 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
-
2022
- 2022-04-29 WO PCT/US2022/027124 patent/WO2022232638A2/en not_active Ceased
- 2022-04-29 AU AU2022264921A patent/AU2022264921A1/en active Pending
- 2022-04-29 CA CA3214222A patent/CA3214222A1/en active Pending
- 2022-04-29 MX MX2023012606A patent/MX2023012606A/es unknown
- 2022-04-29 JP JP2023562936A patent/JP2024517607A/ja active Pending
- 2022-04-29 CN CN202280030364.7A patent/CN117203332A/zh active Pending
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- 2022-04-29 BR BR112023022270A patent/BR112023022270A2/pt unknown
- 2022-04-29 KR KR1020237040583A patent/KR20240004618A/ko active Pending
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2023
- 2023-10-17 US US18/488,520 patent/US20240110167A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024517607A (ja) | 2024-04-23 |
| BR112023022270A2 (pt) | 2024-01-23 |
| US20240110167A1 (en) | 2024-04-04 |
| AU2022264921A1 (en) | 2023-11-23 |
| MX2023012606A (es) | 2023-11-03 |
| EP4330386A4 (en) | 2025-05-14 |
| WO2022232638A2 (en) | 2022-11-03 |
| EP4330386A2 (en) | 2024-03-06 |
| WO2022232638A3 (en) | 2022-12-01 |
| CN117203332A (zh) | 2023-12-08 |
| CA3214222A1 (en) | 2022-11-03 |
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