KR20230170732A - 케토헥소키나제 (khk)를 억제하기 위한 조성물 및 방법 - Google Patents
케토헥소키나제 (khk)를 억제하기 위한 조성물 및 방법 Download PDFInfo
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| PCT/EP2022/059663 WO2022218941A2 (en) | 2021-04-12 | 2022-04-11 | Compositions and methods for inhibiting ketohexokinase (khk) |
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| TW202430192A (zh) | 2022-10-11 | 2024-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療nash之劑量方案 |
| TW202430191A (zh) | 2022-10-11 | 2024-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療伴有晚期纖維化及/或硬化之nash的方法 |
| WO2024175062A1 (zh) * | 2023-02-23 | 2024-08-29 | 大睿生物医药科技(上海)有限公司 | 调控KHK基因活性的dsRNA分子 |
| WO2024260379A1 (zh) * | 2023-06-20 | 2024-12-26 | 施能康医药科技(苏州)有限公司 | 靶向已酮糖激酶的核酸及其用途 |
| CN117925620B (zh) * | 2024-01-30 | 2024-09-03 | 大连医科大学 | 一种果糖激酶khk的小干扰和短发夹rna序列组合及其应用 |
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| US5977343A (en) | 1992-05-14 | 1999-11-02 | Ribozyme Pharmaceuticals, Inc. | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
| US5804683A (en) | 1992-05-14 | 1998-09-08 | Ribozyme Pharmaceuticals, Inc. | Deprotection of RNA with alkylamine |
| ATE227342T1 (de) | 1993-09-02 | 2002-11-15 | Ribozyme Pharm Inc | Enzymatische nukleiksaüre die nicht-nukleotide enthaltet |
| US5889136A (en) | 1995-06-09 | 1999-03-30 | The Regents Of The University Of Colorado | Orthoester protecting groups in RNA synthesis |
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| ES2336887T5 (es) | 2000-03-30 | 2019-03-06 | Whitehead Inst Biomedical Res | Mediadores de interferencia por ARN específicos de secuencias de ARN |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20050159378A1 (en) | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| WO2003040395A2 (en) | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| WO2007030167A1 (en) | 2005-09-02 | 2007-03-15 | Nastech Pharmaceutical Company Inc. | Modification of double-stranded ribonucleic acid molecules |
| DK2341943T3 (en) | 2008-09-22 | 2019-02-25 | Dicerna Pharmaceuticals Inc | COMPOSITIONS AND METHODS OF SPECIFIC INHIBITION OF DSRNA REPRINT WITH MODIFICATIONS |
| KR101728655B1 (ko) | 2008-12-18 | 2017-04-19 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| WO2011005860A2 (en) | 2009-07-07 | 2011-01-13 | Alnylam Pharmaceuticals, Inc. | 5' phosphate mimics |
| WO2011133871A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | 5'-end derivatives |
| AU2012328680A1 (en) | 2011-10-25 | 2014-05-01 | Ionis Pharmaceuticals, Inc. | Antisense modulation of GCCR expression |
| CN113057959B (zh) * | 2014-02-11 | 2024-07-16 | 阿尔尼拉姆医药品有限公司 | 己酮糖激酶（KHK）iRNA组合物及其使用方法 |
| AU2015330670B2 (en) * | 2014-10-10 | 2022-01-06 | Novo Nordisk Health Care Ag | Therapeutic inhibition of lactate dehydrogenase and agents therefor |
| DK3569711T3 (da) * | 2014-12-15 | 2021-02-22 | Dicerna Pharmaceuticals Inc | Ligandmodificerede dobbeltstrengede nukleinsyrer |
| HUE059718T2 (hu) | 2016-09-02 | 2022-12-28 | Dicerna Pharmaceuticals Inc | 4'-foszfát analógok és azokat tartalmazó oligonukleotidok |
| US20210332367A1 (en) * | 2018-09-18 | 2021-10-28 | Alnylam Pharmaceuticals, Inc. | KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| AU2020358016A1 (en) * | 2019-10-02 | 2022-04-21 | Dicerna Pharmaceuticals, Inc. | Chemical modifications of small interfering RNA with minimal fluorine content |
| BR112022017822A2 (pt) * | 2020-03-06 | 2022-11-08 | Alnylam Pharmaceuticals Inc | Composições de irna de cetoexocinase (khk) e métodos de uso das mesmas |
| AU2022226098A1 (en) * | 2021-02-26 | 2023-08-24 | Alnylam Pharmaceuticals, Inc. | KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
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2022
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| TW202305135A (zh) | 2023-02-01 |
| AU2022256742A1 (en) | 2023-09-07 |
| CR20230482A (es) | 2023-12-07 |
| JOP20230250A1 (ar) | 2023-10-12 |
| DOP2023000223A (es) | 2023-11-15 |
| ECSP23076906A (es) | 2023-11-30 |
| CL2023003017A1 (es) | 2024-05-03 |
| WO2022218941A2 (en) | 2022-10-20 |
| EP4323518A2 (en) | 2024-02-21 |
| BR112023017367A2 (pt) | 2023-12-12 |
| PH12023552830A1 (en) | 2024-05-20 |
| US20220340909A1 (en) | 2022-10-27 |
| CA3214439A1 (en) | 2022-10-20 |
| US20250092403A1 (en) | 2025-03-20 |
| PE20250400A1 (es) | 2025-02-11 |
| WO2022218941A3 (en) | 2023-02-23 |
| CN117120612A (zh) | 2023-11-24 |
| JP2024516356A (ja) | 2024-04-15 |
| IL307315A (en) | 2023-11-01 |
| MX2023012048A (es) | 2023-10-23 |
| CO2023013465A2 (es) | 2023-10-30 |
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