KR20230167019A - 이식편 대 숙주 질환의 치료를 위한 조성물 및 방법 - Google Patents

이식편 대 숙주 질환의 치료를 위한 조성물 및 방법 Download PDF

Info

Publication number
KR20230167019A
KR20230167019A KR1020237029222A KR20237029222A KR20230167019A KR 20230167019 A KR20230167019 A KR 20230167019A KR 1020237029222 A KR1020237029222 A KR 1020237029222A KR 20237029222 A KR20237029222 A KR 20237029222A KR 20230167019 A KR20230167019 A KR 20230167019A
Authority
KR
South Korea
Prior art keywords
subject
administered
gvhd
apraglutide
afraglutide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237029222A
Other languages
English (en)
Korean (ko)
Inventor
바이오레타 디미트리아도우
나데르 엔. 유세프
Original Assignee
벡티브바이오 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 벡티브바이오 에이지 filed Critical 벡티브바이오 에이지
Publication of KR20230167019A publication Critical patent/KR20230167019A/ko
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020237029222A 2021-01-28 2022-01-28 이식편 대 숙주 질환의 치료를 위한 조성물 및 방법 Pending KR20230167019A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163142905P 2021-01-28 2021-01-28
US63/142,905 2021-01-28
US202163248074P 2021-09-24 2021-09-24
US63/248,074 2021-09-24
PCT/US2022/014349 WO2022165204A1 (en) 2021-01-28 2022-01-28 Compositions and methods for the treatment of graft versus host disease

Publications (1)

Publication Number Publication Date
KR20230167019A true KR20230167019A (ko) 2023-12-07

Family

ID=80461100

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237029222A Pending KR20230167019A (ko) 2021-01-28 2022-01-28 이식편 대 숙주 질환의 치료를 위한 조성물 및 방법

Country Status (11)

Country Link
US (3) US20220233645A1 (https=)
EP (2) EP4635509A1 (https=)
JP (1) JP2024507324A (https=)
KR (1) KR20230167019A (https=)
AU (1) AU2022212119A1 (https=)
BR (1) BR112023014978A2 (https=)
CA (1) CA3206093A1 (https=)
ES (1) ES3044110T3 (https=)
IL (1) IL304675A (https=)
MX (1) MX2023008793A (https=)
WO (1) WO2022165204A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025208047A1 (en) * 2024-03-28 2025-10-02 Vectivbio Ag Glucagon-like peptide 2 (glp-2) analogs for the treatment of graft versus host disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8421271B2 (en) * 2009-08-31 2013-04-16 General Electric Company Apparatus for transferring energy using onboard power electronics and method of manufacturing same
EP2314616A1 (en) 2009-10-23 2011-04-27 Ferring B.V. Peptidic GLP-2 agonists
EP3924369A1 (en) * 2019-02-11 2021-12-22 OPKO Biologics Ltd. Long-acting glp-2 analogs
KR20230038187A (ko) 2020-06-09 2023-03-17 벡티브바이오 에이지 아프라글루타이드의 제조, 제형화 및 투여

Also Published As

Publication number Publication date
IL304675A (en) 2023-09-01
JP2024507324A (ja) 2024-02-19
ES3044110T3 (en) 2025-11-26
AU2022212119A1 (en) 2023-08-10
AU2022212119A9 (en) 2024-05-16
EP4635509A1 (en) 2025-10-22
BR112023014978A2 (pt) 2023-11-07
EP4284410A1 (en) 2023-12-06
CA3206093A1 (en) 2022-08-04
EP4284410B1 (en) 2025-07-02
WO2022165204A1 (en) 2022-08-04
US20240123036A1 (en) 2024-04-18
US20220233645A1 (en) 2022-07-28
US20240285730A1 (en) 2024-08-29
MX2023008793A (es) 2024-02-15

Similar Documents

Publication Publication Date Title
JP7445893B2 (ja) ヒトにおける固形腫瘍の処置のためのC.novyi
CA3089391A1 (en) Composition and method for reducing chemotherapy-induced neutropenia via the administration of plinabulin and a g-csf agent
JP2020517696A5 (https=)
CN105722852A (zh) 用于治疗口腔粘膜炎的新型肽和类似物
US20240285730A1 (en) Compositions and methods for the treatment of graft versus host disease
Martin et al. Evaluation of oral beclomethasone dipropionate for prevention of acute graft-versus-host disease
US20080199478A1 (en) Combinations of Immunosupressive Agents for the Treatment or Prevention of Graft Rejections
CN117460523A (zh) 用于治疗移植物抗宿主病的组合物和方法
HK40102861A (en) Apraglutide for use in the treatment of gastrointestinal graft versus host disease
HK40102861B (en) Apraglutide for use in the treatment of gastrointestinal graft versus host disease
EA051756B1 (ru) Композиции и способы лечения болезни "трансплантат против хозяина"
WO2025208047A1 (en) Glucagon-like peptide 2 (glp-2) analogs for the treatment of graft versus host disease
US10154989B2 (en) Methods of managing graft versus host disease (GvHD) using indole carboxyaldehydes or derivatives thereof
CN105916517A (zh) 用于治疗或缓解高龄或晚期癌症患者的药物组合物
TWI798243B (zh) 治療癌症的方法
WO2025130826A1 (en) Compositions and methods for treating cancer
Han et al. Artesunate synergized dexamethasone in protecting intestinal barrier against acute graft-versus-host disease in a murine model
Raida et al. Allogeneic stem cell transplantation after fludarabine, melphalan and thymoglobulin followed by early withdrawal of prophylactic immunosuppression could be an effective approach to patients with acute lymphoblastic leukemia
Karmali et al. Combinatorial treatment with carboxyamidotriazole-orotate and temozolomide in sc-implanted human LOX IMVI melanoma xenografts
WO2025032079A1 (en) Combination of a mps1 inhibitor and an antibody drug conjugate
Raida et al. Allogeneic stem cell transplantation after fludarabine, melphalan and thymoglobulin followed by early withdrawal of prophylactic immunosuppression in patients with acute lymphoblastic leukemia-update of single center study
JP4838497B2 (ja) 肝移植後の拒絶反応の予防または治療用医薬組成物
NZ787735B2 (en) Rubidium and/or zinc compounds for treating parkinson's and other neurodegenerative diseases
CA3154497A1 (en) Combination therapy for treating a hematological malignancy
Martella et al. A pilot study of a day one and eight every three weeks administration of docetaxel in metastatic cancer patients

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20230828

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250122

Comment text: Request for Examination of Application