KR20230158917A - 한국인 친족 관계 확인을 위한 482개의 snp 패널 및 이의 용도 - Google Patents
한국인 친족 관계 확인을 위한 482개의 snp 패널 및 이의 용도 Download PDFInfo
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Abstract
본 발명은 한국인 친족관계 확인용 482개의 SNP 패널에 대한 정보와 이의 용도에 관한 것이다.
본 발명의 한국인 친족관계 확인용 482개의 SNP 패널을 이용하면, 대조 가능한 직계, 즉 부모의 DNA를 얻을 수 없는 경우에도 최소한의 법의학적 SNP 마커 수로 한국인 집단에서 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 하나인 first degree relative 관계일 가능성이 있는 개체와 first degree relative 관계가 아닐 가능성이 있는 개체에 대한 정보를 제공하는 데에 유용하게 사용할 수 있다.
본 발명의 한국인 친족관계 확인용 482개의 SNP 패널을 이용하면, 대조 가능한 직계, 즉 부모의 DNA를 얻을 수 없는 경우에도 최소한의 법의학적 SNP 마커 수로 한국인 집단에서 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 하나인 first degree relative 관계일 가능성이 있는 개체와 first degree relative 관계가 아닐 가능성이 있는 개체에 대한 정보를 제공하는 데에 유용하게 사용할 수 있다.
Description
본 발명은 한국인 친족 관계 확인을 위한 SNP 패널 및 이의 용도에 관한 것이다.
STR(short tandem repeats)은 HLA(human leukocyte antigen, 백혈구세포의 막단백질)의 유전자에서 시작된 개념으로, 유전자에서 1개 내지 6개의 염기가 하나의 모티프(motif)를 구성하여 그 모티프가 반복되는 것을 의미한다. 이는 세대를 거쳐 유전되며, 비교적 다형의 정도가 높아 유전 질병의 판단에 사용하거나 법과학에서는 미합중국 연방수사(FBI)의 CODIS(Combined DNA Index System)에서 꾸준히 유지 및 관리되고 있으며, 개인 식별, 가족관계 확인에 사용할 수 있는 유전자 마커이다.
이러한 STR을 이용한 개인식별이나 가족관계 확인 방법은 여러 모티프가 이루는 전체 유전자의 크기를 모세관 전기 영동(capillary electrophoresis) 방식으로 측정하여 모티프의 반복 개수를 예측하는 방식이다. 그러나, 이러한 방법은 증폭된 개인 유전자 내의 변이(variants, mutation)가 있을 경우 부정확한 결과를 초래할 수 있으며, DNA 수득율이 낮고 훼손이 심한 시료에서 유전자의 길이가 300 bp 이상인 경우 감정이 불가한 경우도 있다.
이러한 제한점은 이미 범 국가적 유전체 연구가 이루어진 2000년대 초반부터 학계에 다수 보고된 바 있으며, 한계를 극복할 수 있는 다양한 기술이 제안되고 있다. 특히, DNA 염기서열분석(DNA sequencing) 방법이 발전하면서 차세대 염기서열분석(next generation sequencing, NGS) 방식을 이용하여 더 많은 수의 유전자 변이에 대한 법과학수사에 세계적으로 점진적인 도입과 적용이 이루어지고 있다.
또한, 현재 국내에서 불상변사자 및 실종아동분석은 A-STR을 기준으로 불상변사자군과 불상변사자 보호자군, 실종아동군과 실종아동보호자의 일대일 비교 및 상호검색으로 친자 확인(1촌)만 가능하고, 그 이상의 관계는 일대일 특정인 간 비교만 가능 하며, 일대 다수의 검색이 불가능하다. 한국인의 유전체를 분석하여 2촌 이상의 친족관계 확인할 수 있는 최소한의 법과학적 SNPs 마커를 개발이 필요하다.
Kim J, Weber JA, Jho S, Jang J, Jun J, Cho YS, Kim HM, Kim H, Kim Y, Chung O, Kim CG, Lee H, Kim BC, Han K, Koh I, Chae KS, Lee S, Edwards JS, Bhak J. KoVariome: Korean National Standard Reference Variome database of whole genomes with comprehensive SNV, indel, CNV, and SV analyses. Sci Rep. 2018 Apr 4;8(1):5677.
본 발명자들은 한국인 집단에서 친족 관계를 확인할 수 있는 최소한의 법의학적 SNP 마커를 개발하고자 예의 연구 노력하였다. 그 결과, 한국 표준 참조 변이체(KoVariome) 데이터베이스에 개시된 서로 관련이 없는 한국인 88명의 약 8천 4백만 개의 SNP로부터 한국인 집단에서 친족관계 확인을 위한 918개의 SNP 마커 및 482개의 SNP 마커를 발굴하였으며, 이를 이용해 1촌 내지 4촌 관계에 있는 한국인 집단에서 본인을 기준으로 부모, 자식, 형제, 자매, 남매 중 하나인 first degree relative 관계인 개체와 first degree relative 관계가 아닌 개체를 명확하게 구분하였고, 부모의 DNA 정보가 없는 경우에도 본인을 기준으로 형제, 자매, 남매 중 하나의 관계인 개체와 이들 관계가 아닌 개체를 구별할 수 있음을 규명함으로써, 한국인 친족관계 확인용 SNP 패널을 완성하였다.
따라서, 본 발명의 목적은 한국인 친족관계 확인용 SNP 패널을 제공하는 것이다.
본 발명의 다른 목적은 상술한 SNP 패널을 포함하는 한국인 친족관계 확인용 조성물 또는 키트를 제공하는 것이다.
본 발명의 또 다른 목적은 상술한 SNP의 염기 종류를 확인하는 단계를 포함하는 한국인 친족관계 확인 방법을 제공하는 것이다.
본 발명의 일 양태에 따르면, 본 발명은 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 단일염기다형성(single nucleotide polymorphism, SNP)을 증폭 또는 검출하는 제제를 포함하는, 한국인 친족관계 확인용 조성물을 제공한다.
본 발명자들은 한국인 집단에서 친족 관계를 확인할 수 있는 최소한의 법의학적 SNP 마커를 개발하고자 예의 연구 노력하였다. 그 결과, 한국 표준 참조 변이체(KoVariome) 데이터베이스에 개시된 서로 관련이 없는 한국인 88명의 약 8천 4백만 개의 SNP로부터 한국인 집단에서 친족관계 확인을 위한 918개의 SNP 마커 및 482개의 SNP 마커를 발굴하였으며, 이를 이용해 1촌 내지 4촌 관계에 있는 한국인 집단에서 본인을 기준으로 부모, 자식, 형제, 자매, 남매 중 하나인 first degree relative 관계인 개체와 first degree relative 관계가 아닌 개체를 명확하게 구분하였고, 부모의 DNA 정보가 없는 경우에도 본인을 기준으로 형제, 자매, 남매 중 하나의 관계인 개체와 이들 관계가 아닌 개체를 구별할 수 있음을 규명하였다.
따라서, 본 발명에 따른 한국인 친족관계 확인용 조성물은, 종래의 감정에 사용하는 STR 기법으로는 해결할 수 없었던 경우인, 부모의 정보가 없는 형제, 자매, 또는 남매의 관계를 확인하는 경우, 개인 CODIS-23좌위 내의 변이가 있는 경우, 분석 대상 시료의 백골화나 부패로 인해 DNA 단편화가 심한 경우, 및 대상 시료와 유가족의 유전적 거리가 먼 경우에도 활용될 수 있다. 또한, 기존의 STR 기법과는 다르게 NGS기법을 이용하여 여러 시료에서 염색체상의 다수의 SNP를 한꺼번에 확인할 수 있으므로, 대형 재난에서 발생할 수 있는 다수 사상자의 신원 파악 등에 대비에도 큰 역할을 할 것으로 기대된다.
구체적으로, STR 마커를 이용하는 경우에는 유전자 좌위에 있는 80 bp 내지 400 bp 크기의 모티프가 완전하게 복제되어야만 해당 유전자 좌위의 정확한 대립유전자 유형(allele type)을 확인할 수 있는 반면에, 본 발명에 따른 한국인 친족관계 확인용 조성물을 이용하는 경우에는 각 SNP 마커에 대한 단일 염기만을 확인하면 되므로, 분석 대상의 시료가 백골화 상태이거나 부패가 심하여 시료의 DNA 단편화가 심한 경우에도, 친족관계 확인이 가능하다.
또한, 개인 CODIS-23좌위 내 변이가 있는 경우에는 생물학적으로 서로 가족 관계임이 확실함에도 불구하고 부모 세대와 다른 대립유전자 유형을 갖는 것으로 다수 보고된 바가 있어, CODIS-23좌위에서 STR 기법을 이용한 친족관계 감정에는 한계가 있지만, 본 발명에 따른 918개 SNP 패널 및 482개 SNP 패널은 반복 영역에 있는 SNP 유전자 좌위를 제외하고 선별하였으므로 개인 CODIS-23좌위 내 변이가 있는 경우에도 친족관계 확인이 가능하다.
특히, 종래의 STR 마커 또는 약 105개 내지 106개의 SNP를 이용한 친족 테스트와 비교하여 본 발명의 한국인 친족관계 확인용 조성물은 918개 및/또는 482개의 SNP 마커만을 이용하여도 한국인 집단에서 본인을 기준으로 first degree relative 관계인 개체와 first degree relative 관계가 아닌 개체를 명확하게 구분할 수 있다는 점에서 법의학 사용에 실용적이다.
본 명세서에서는 용어, "염기서열분석", "시퀀싱(sequencing)" 및 "유전체 해독"은 서로 차이가 없으며 본 명세서에서 혼용된다.
본 명세서에서, 용어 “단일염기다형성(single nucleotide polymorphism, SNP)"은 유전체 특정 위치의 단일 염기에서의 변이를 의미한다. 상기 SNP는 여러 개체의 유전체의 동일 위치에서 특정 단일 염기가 다른 염기로 변이된 것을 포괄하는 의미이다.
본 명세서에서, 용어 “패널 (panel)”은 특이적인 마커 세트를 의미한다.
본 명세서에서, 용어 “SNP 패널”은 특이적인 SNP 마커 세트를 의미한다.
본 명세서에서, 용어 “WGS(Whole genome sequencing)”는 세포 또는 유기체의 모든 유전 물질의 총합인 유전체(genome)에서 염기의 정확한 순서를 결정하는 방법을 의미한다(JAMA. 2014;311(10):1035-1045).
본 발명의 일 구현예에 있어서, 상기 조성물은 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 50개, 100개, 150개, 200개, 250개, 300개, 350개, 400개, 450개, 또는 482개의 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함한다.
본 발명의 다른 일 구현예에 있어서, 상기 조성물은 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함한다.
본 발명의 일 구현예에 있어서, 상기 조성물은 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 추가적으로 포함한다.
본 발명의 다른 일 구현예에 있어서, 상기 조성물은 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 100개, 200개, 300개, 400개, 500개, 600개, 700개, 800개, 900개, 또는 918개의 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 추가적으로 포함한다.
본 발명의 또 다른 일 구현예에 있어서, 상기 조성물은 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 추가적으로 포함한다.
상기 SNP는 GRCh37/hg19 또는 GRCh38/hg38과 같은 인간 참조 유전체(reference genome)로부터 추출된 것일 수 있다.
본 명세서에서, 용어 “참조 유전체(reference genome)"는 염기서열분석이 완료되어 공공 데이터베이스로 구축되어 있는 표준 염기서열을 의미한다.
본 발명의 일 구현예에 있어서, 상기 SNP는 유전체 기능 요소(genome functional element) 영역 내, 또는 이의 100 kbp (kilo base pair) 업스트림(upstream) 또는 100 kbp 다운스트림(upstream) 사이에 위치하지 않는다.
본 발명의 일 구체예에 있어서, 상기 유전체 기능 요소는 엑손(exon) 또는 코딩 서열(coding sequence)이다. 즉, 본 발명의 SNP는 엑손 또는 코딩 서열에 위치하지 않는다.
본 발명의 다른 일 구체예에 있어서, 상기 SNP는 엑손 또는 코딩 서열 내, 또는 이의 100 kbp 업스트림 및 100 kbp 다운스트림 사이에 위치하지 않는다.
본 발명의 일 구현예에 있어서, 상기 SNP는 하디-바인베르크 평형(Hardy-Weinberg equilibrium, HWE) 테스트에 대한 p value가 0.05 이상이다. 본 발명의 다른 일 구현예에 있어서, 상기 SNP는 하디-바인베르크 평형(Hardy-Weinberg equilibrium, HWE) 테스트에 대한 p value가 0.05 초과이다.
본 발명의 일 구현예에 있어서, 상기 SNP는 한국 표준 참조 변이체 데이터베이스(Korea National Standard Reference Variome database)인 코베리옴(KoVariome)에서 추출된 것이나, 반드시 이에 제한되는 것은 아니다. 코베리움에 대한 세부 사항은 Kim J. et al. (KoVariome: Korean National Standard Reference Variome database of whole genomes with comprehensive SNV, indel, CNV, and SV analyses. Sci Rep. 2018 Apr 4;8(1):5677)에 개시되어 있다.
본 발명의 일 구현예에 있어서, 상기 SNP에 대한 한국인 집단 대립유전자 빈도는 0.3 내지 0.7이다. 본 발명의 다른 일 구현예에 있어서, 상기 SNP에 대한 한국인 집단 대립유전자 빈도는 0.4 내지 0.6이다.
본 발명의 일 구체예에 있어서, 상기 SNP는 한국 표준 참조 변이체 데이터베이스(Korea National Standard Reference Variome database)인 코베리옴(KoVariome)에서 한국인 집단 대립유전자 빈도가 0.4 내지 0.6인 SNP를 추출한 것이다.
본 명세서에서, 용어 “대립유전자 빈도(variant allele frequency, VAF)"는 유전체 특정 유전자좌(loci)에 대립유전자(allele)가 나타나는 빈도를 의미한다. 본 발명의 목적상 용어 대립유전자 빈도는 한국인 집단에서 유전체 특정 유전자좌에 대립유전자가 나타나는 빈도를 의미한다.
본 발명의 일 구현예에 있어서, 상기 SNP는 연관 비평형(linkage disequilibrium, LD)에 위치하지 않는다. 본 발명의 다른 일 구현예에 있어서, 상기 SNP는 HaploReg v4.1 데이터베이스(Ward, L. D., & Kellis, M. (2016). HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease. Nucleic Acids Res., 44(D1), D877-D881. http://compbio.mit.edu/HaploReg)를 이용하여 연관 비평형에 위치한 SNP를 제외한 것이다. 본 발명의 일 구체예에 있어서, 상기 HaploReg v4.1 데이터베이스를 이용하여 연관 비평형에 위치한 SNP를 제외하는 것은 r2 값이 0.2 이상인 SNP를 제거하는 것이다.
본 발명의 일 구현예에 있어서, 상기 SNP는 당업계에 공지된 유전체의 반복 영역(repeat region)에 위치하지 않는다. 본 발명의 다른 일 구현예에 있어서, 상기 SNP는 www.repeatmasker.org/species/hg.html에 개시된 반복 영역에 위치한 SNP를 제외한 것이다.
본 발명의 일 구현예에 있어서, 상기 제제는 프라이머, 프로브, 또는 이들의 조합이다.
본 명세서에서, 용어 “프라이머(primer)"는 핵산 가닥(템플레이트)에 상보적인 프라이머 연장 산물의 합성이 유도되는 조건 하에서, 즉, 뉴클레오타이드와 DNA 중합효소와 같은 중합제의 존재 시, 그리고 적합한 온도와 pH에서 합성의 개시점으로 작용할 수 있는 올리고뉴클레오타이드를 의미한다
본 명세서에서, 용어 “프로브(probe)"는 타겟 핵산 서열에 실질적으로 상보적인 부위 또는 부위들을 포함하는 단일-가닥 핵산 분자를 의미한다. 상기 프로브에는 형광성 물질 및/또는 퀀처가 표지되어 있을 수 있다.
본 발명에 이용될 수 있는 형광성 리포터 분자 및 퀀처 분자는 당업계에 공지되어 있는 어떠한 것도 이용할 수 있으며, 그 예는 다음과 같다(괄호의 숫자는 나노미터 단위로 표시한 발광 최대 파장이다): Cy2TM(506), YOPROTM-1(509), YOYOTM-1(509), Calcein(517), FITC(518), FluorXTM(519), AlexaTM(520), rhodamine 110(520), 5-FAM(522), Oregon GreenTM500(522), Oregon GreenTM488(524), RiboGreenTM(525), RhodamineGreenTM(527), Rhodamine 123(529), Magnesium GreenTM(531), Calcium GreenTM(533), TO-PROTM-1(533), TOTO1(533), JOE(548), BODIPY530/550(550), Dil(565), BODIPY TMR(568), BODIPY558/568(568), BODIPY564/570(570), Cy3TM(570), AlexaTM546(570), TRITC(572), Magnesium OrangeTM(575), Phycoerythrin R&B(575), Rhodamine Phalloidin(575), Calcium OrangeTM(576), Pyronin Y(580), RhodamineB(580), TAMRA(582), Rhodamine RedTM(590), Cy3.5TM(596), ROX(608), Calcium CrimsonTM(615), AlexaTM594(615), Texas Red(615), Nile Red(628), YO-PROTM-3(631), YOYOTM-3(631), Rphycocyanin(642), CPhycocyanin(648), TO-PROTM-3(660), TOTO3(660), DiD DilC(5)(665), Cy5TM(670), Thiadicarbocyanine(671), Cy5.5(694), HEX(556), TET(536), VIC(546), BHQ-1(534), BHQ-2(579), BHQ-3(672), BiosearchBlue(447), CAL Fluor Gold 540(544), CAL Fluor Orange 560(559), CAL Fluor Red 590(591), CAL FluorRed 610(610), CAL Fluor Red 635(637), FAM(520), Fluorescein(520), Fluorescein-C3(520), Pulsar 650(566), Quasar 570(667), Quasar 670(705), Quasar 705(610) 및 TxR(592).
적합한 리포터-퀀처 쌍(pairs)은 많은 문헌에 개시되어 있다: Pesce et al., editors, FLUORESCENCE SPECTROSCOPY(Marcel Dekker, New York, 1971); White et al., FLUORESCENCE ANALYSIS: A PRACTICAL APPROACH(Marcel Dekker, New York, 1970); Berlman, HANDBOOK OF FLUORESCENCE SPECTRA OF AROMATIC MOLECULES, 2nd EDITION (Academic Press, New York, 1971); Griffiths, COLOUR AND CONSTITUTION OF ORGANIC MOLECULES(Academic Press, New York, 1976); Bishop, editor, INDICATORS(Pergamon Press, Oxford, 1972); Haugland, HANDBOOK OF FLUORESCENT PROBES AND RESEARCH CHEMICALS(Molecular Probes, Eugene, 1992); Pringsheim, FLUORESCENCE AND PHOSPHORESCENCE(Interscience Publishers, New York, 1949); Haugland, R. P., HANDBOOK OF FLUORESCENT PROBES AND RESEARCH CHEMICALS, Sixth Edition, Molecular Probes, Eugene, Oreg., 1996; U.S. Pat. Nos. 3,996,345 and 4,351,760.
상기 "타겟 핵산", "타겟 핵산 서열" 또는 "타겟 서열"은 검출하고자 하는 핵산 서열을 의미하며, 혼성화, 어닐링, 또는 증폭 조건 하에서 프라이머 또는 프로브와 어닐링 또는 혼성화된다.
보다 구체적으로는 프로브 및 프라이머는 단일-가닥 데옥시리보뉴클레오타이드 분자이다. 본 발명에서 이용되는 프로브 또는 프라이머는 자연(naturally occurring) dNMP(즉, dAMP, dGMP, dCMP 및 dTMP), 변형 뉴클레오타이드 또는 비-자연 뉴클레오타이드를 포함할 수 있다. 또한, 프로브 또는 프라이머는 리보뉴클레오타이드를 포함할 수 있다.
프라이머는 중합제의 존재하에서 연장 산물의 합성을 프라이밍 시킬 수 있을 정도로 충분히 길어야 한다. 프라이머의 정확한 길이는 예컨대, 온도, 응용분야 및 프라이머의 소스(source)를 포함한 복수의 요소에 따라 결정된다.
본 명세서에서 사용되는 용어 "어닐링" 또는 "프라이밍"은 템플레이트 핵산에 올리고데옥시뉴클레오타이드 또는 핵산이 병치(apposition)되는 것을 의미하며, 상기 병치는 중합효소가 뉴클레오타이드를 중합시켜 템플레이트 핵산 또는 그의 일부분에 상보적인 핵산 분자를 형성하게 한다.
본 발명에 이용되는 프라이머는 주형의 한 부위에 혼성화 또는 어닐링되어, 이중쇄 구조를 형성한다. 이러한 이중쇄 구조를 형성하는 데 적합한 핵산 혼성화의 조건은 Joseph Sambrook, 등, Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.(2001) 및 Haymes, B. D., 등, Nucleic Acid Hybridization, A Practical Approach, IRL Press, Washington, D.C. (1985)에 개시되어 있다.
본 명세서에서, 용어 “혼성화(hybridization)"는 상보적인 단일 가닥 핵산들이 이중-가닥 핵산을 형성하는 것을 의미한다. 혼성화는 완전히 일치하거나 일부 미스매치로 실질적으로 일치하는 2개의 핵산 가닥 사이에서 일어날 수 있다. 혼성화를 위한 상보성은 혼성화 조건, 특히 온도에 따라 달라질 수 있다. 본 명세서에서, 용어 "어닐링"과 "혼성화"는 차이가 없으며 본 명세서에서 혼용된다.
본 발명의 일 구현예에 있어서, 상기 프라이머 또는 프로브에 의해 상기 SNP가 증폭되거나 검출된다.
상기 프라이머 및/또는 프로브를 사용하여 본 발명에 따른 SNP를 포함하는 뉴클레오타이드 서열을 증폭하거나 검출할 수 있다.
상기 증폭은 유전자 증폭에 의해 실시된다.
본 발명의 일 구현예에 있어서, 상기 유전자 증폭은 중합효소연쇄반응 (polymerase chain reaction, PCR) 방식에 의해 실시된다.
본 발명의 일 구현예에 있어서, 상기 중합효소연쇄반응은 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 선택되는 적어도 1개, 적어도 10개, 적어도 50개, 적어도 100개, 적어도 150개, 적어도 200개, 적어도 250개, 적어도 300개, 적어도 350개, 적어도 400개, 적어도 450개, 또는 482개의 서열에서 101번째 염기에 위치한 SNP를 동시에 증폭하거나 검출한다.
본 발명의 다른 일 구현예에 있어서, 상기 중합효소연쇄반응은 표 1 및 표 2의 서열번호 1 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 선택되는 적어도 1개, 적어도 10개, 적어도 100개, 적어도 200개, 적어도 300개, 적어도 400개, 적어도 500개, 적어도 600개, 적어도 700개, 적어도 800개, 적어도 900개, 적어도 1000개, 적어도 1100개, 적어도 1200개, 적어도 1300개, 또는 1400개의 서열에서 101번째 염기에 위치한 SNP를 동시에 증폭하거나 검출한다.
상기 검출은 멀티플렉스 검출일 수 있다. 상기 "멀티플렉스 검출" 또는 "멀티플렉싱 검출"은 반응 용기(예컨대, 반응 튜브)에서 복수의 타겟 핵산서열을 동시적으로 검출하는 것을 의미한다
상기 중합효소연쇄반응(PCR)은 가장 잘 알려진 핵산 증폭 방법으로, 그의 많은 변형과 응용들이 개발되어 있다. 예를 들어, PCR의 특이성 또는 민감성을 증진시키기 위해 전통적인 PCR 절차를 변형시켜 터치다운(touchdown) PCR, 핫 스타트(hot start) PCR, 네스티드(nested) PCR 및 부스터(booster) PCR이 개발되었다. 또한, 실시간 (real-time) PCR, 분별 디스플레이 PCR(differential display PCR: DD-PCR), cDNA 말단의 신속 증폭(rapid amplification of cDNA ends: RACE), 멀티플렉스 PCR, 인버스 중합효소 연쇄반응(inverse polymerase chain reaction: IPCR), 벡토레트(vectorette) PCR, TAIL-PCR(thermal asymmetric interlaced PCR)및 멀티플렉스 PCR이 특정한 응용을 위해 개발되었다. PCR에 대한 자세한 내용은 McPherson, M.J., 및 Moller, S.G. PCR. BIOS Scientific Publishers, Springer-Verlag New York Berlin Heidelberg, N.Y. (2000)에 기재되어 있으며, 그의 교시사항은 본 명세서에 참조로 삽입된다.
본 명세서에서, 용어 “멀티플렉스 PCR(multiplex PCR)"은 반응 용기에서 중합효소 연쇄 반응 (polymerase chain reaction)에 의하여 복수의 타겟이 동시적으로 증폭되는 것을 의미한다.
상기 중합효소연쇄반응에는 다양한 DNA 중합효소가 이용될 수 있으며, E. coli DNA 중합효소 I의 '클레나우' 단편, 열안정성 DNA 중합효소 및 박테리오파아지 T7 DNA 중합효소를 포함한다. 구체적으로는, 중합효소는 다양한 박테리아 종으로부터 얻을 수 있는 열안정성 DNA 중합효소이고, 이는 Thermus aquaticus(Taq), Thermus thermophilus(Tth), Thermus filiformis, Thermis flavus, Thermococcus literalis, 및 Pyrococcus furiosus(Pfu)를 포함한다.
본 발명의 일 구현예에 있어서, 상기 조성물은 Taq DNA 중합효소 또는 Pfu DNA 중합효소를 포함한다.
상기 PCR에 의한 산물은 RCA(rolling circle replication)에 의해 복제될 수 있다.
상기 PCR에 의한 산물을 이용하여 DNA 나노 볼 염기서열분석(DNA nanoball sequencing)을 수행할 수 있다.
본 명세서에서, 용어 “DNA 나노 볼 염기서열분석(DNA nanoball sequencing)"은 RCA(rolling circle replication)를 이용하여 DNA 단편을 증폭시켜 DNA 카피가 긴 가닥으로 연결되어 압축된 DNA 연쇄체(DNA concatemer)를 형성함으로써 전체 유전체 염기서열을 분석하는 대용량 염기서열 분석법을 의미한다.
본 발명의 일 구현예에 있어서, 상기 SNP를 증폭 또는 검출하는 제제는 시퀀싱(sequencing)을 위한 프라이머(primer), 올리고머(oligomer), 어댑터(adaptor), 바코드 서열(barcode), 또는 인덱스 서열(index sequence)일 수 있다.
본 발명의 일 구체예에 있어서, 상기 시퀀싱을 위한 프라이머, 올리고머, 어댑터, 바코드 서열, 또는 인덱스 서열은 상술한 서열번호 919 내지 서열번호 1400 및/또는 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열에서 101번째 염기에 위치한 SNP를 포함하는 적어도 10개의 연속된 뉴클레오타이드 또는 이의 상보적인 뉴클레오타이드 서열을 포함할 수 있다.
상기 시퀀싱을 위한 어댑터(adaptor)는 시퀀싱용 플로우 셀(flow cell)을 코팅하는 서열에 상보적으로 설계될 수 있다. 시료내 DNA는 상기 플로우 셀에 부착된 다음 합성되고 이의 서열이 결정될 수 있다.
시퀀싱을 위한 바코드 서열(barcode), 또는 인덱스 서열(index sequence)은 다수의 시료내 DNA 또는 이들로부터 수득한 DNA 라이브러리를 멀티플렉싱하는 데에 사용될 수 있다. 시료내 DNA 또는 이들로부터 수득한 DNA 라이브러리를 바코드 서열 또는 인덱스 서열로 인덱싱하면 다수의 시료 또는 이들로부터 수득한 DNA 라이브러리를 풀링(pooling)하여 한꺼번에 시퀀싱을 실시할 수 있다. 상술한 인덱싱은 싱글 인덱싱 또는 듀얼 인덱싱의 방식으로 적용될 수 있다.
본 발명에 따른 표 2 및/또는 표 1의 서열번호 919 내지 서열번호 1400 및/또는 서열번호 1 내지 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서, 또는 이들 서열 모두에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함하는, 한국인 친족관계 확인용 조성물은 당업계에 공지된 시퀀싱 플랫폼, 예컨대 Illumina®, Thermo Fisher Scientific Ion TorrentTM, Helicos Biosciences tSMS(true Single Molecule Sequencing), PacBio SMRTTM(Single-molecule real time), GridIONTM, MinIONTM 등에서 사용될 수 있으나, 반드시 이에 제한되는 것은 아니다.
본 명세서에서, 용어 "First degree relative"는 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 하나를 의미한다. 본 명세서에서 용어 "First degree relative"는 first-d-r로 약칭될 수 있다.
본 명세서에서, 용어 "Second degree relative"는 본인을 기준으로 이모, 삼촌, 고모, 할아버지, 할머니, 부모 한쪽이 다른 형제, 자매 및 남매 중 하나를 의미한다. 본 명세서에서 용어 "Second degree relative"는 second-d-r로 약칭될 수 있다.
본 명세서에서, 용어 "Third degree relative"는 본인을 기준으로 친사촌(First cousin)인 관계를 의미한다. 본 명세서에서 용어 "Third degree relative"는 third-d-r로 약칭될 수 있다.
본 발명의 일 구현예에 있어서, 상기 친족관계는 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나이다. 즉, 상기 친족관계는 대상을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나이다. 본 발명에 따른 한국인 친족관계 확인용 조성물을 이용하는 경우 부모, 자식, 형제, 자매 및 남매 중 어느 하나인 First-d-r 인 개체를 First-d-r 가 아닌 개체로부터 구별할 수 있다. 즉, 본 발명에 따른 조성물은 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 관계인 개체를 이들 관계가 아닌 개체로부터 구별할 수 있다.
본 발명의 다른 일 구현예에 있어서, 상기 친족관계는 형제, 자매 및 남매 중 어느 하나이다. 본 발명에 따른 한국인 친족관계 확인용 조성물을 이용하는 경우 형제, 자매 및 남매 중 어느 하나인 First-d-r 인 개체를 First-d-r 가 아닌 개체로부터 구별할 수 있다. 즉, 본 발명에 따른 조성물은 부모의 DNA 정보 없이도, 본인을 기준으로 형제, 자매 및 남매 중 어느 하나의 관계인 개체를 이들 관계가 아닌 개체로부터 구별할 수 있다.
본 발명의 다른 일 구현예에 있어서, 상기 친족관계는 한국 촌수 기준으로 2촌 이내 관계, 즉 부모-자식 관계, 일란성 쌍둥이 관계, 또는 친형제(full sibling) 관계이다. 본 발명에 따른 한국인 친족관계 확인용 조성물을 이용하는 경우 2촌 이내 관계인 개체를 2촌 이내 관계가 아닌 개체로부터 구별할 수 있다.
본 발명의 일 구현예에 있어서, 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함하는, 한국인 친족관계 확인용 조성물은 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 관계인 개체를 이들 관계가 아닌 개체로부터 구별할 수 있다.
본 발명의 다른 일 구현예에 있어서, 표 1 및 표 2의 서열번호 1 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함하는, 한국인 친족관계 확인용 조성물은 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 관계인 개체를 이들 관계가 아닌 개체로부터 구별할 수 있다.
본 발명의 또 다른 일 구현예에 있어서, 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함하는, 한국인 친족관계 확인용 조성물은 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 관계인 개체를 이들 관계가 아닌 개체로부터 구별할 수 있다.
본 발명의 다른 일 양태에 따르면, 본 발명은 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 포함하는 적어도 10개의 연속적인 뉴클레오타이드를 포함하는 폴리뉴클레오타이드, 또는 이의 상보적인 폴리뉴클레오타이드를 포함하는, 한국인 친족관계 확인용 마커 조성물을 제공한다.
본 발명의 일 구현예에 있어서, 상기 마커 조성물은 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 포함하는 적어도 10개의 연속적인 뉴클레오타이드를 포함하는 폴리뉴클레오타이드, 또는 이의 상보적인 폴리뉴클레오타이드를 추가적으로 포함한다.
본 발명의 다른 일 구현예에 있어서, 상기 마커 조성물은 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열에서 101번째 염기에 위치한 SNP를 포함하는 적어도 10개의 연속적인 뉴클레오타이드를 포함하는 폴리뉴클레오타이드, 또는 이의 상보적인 폴리뉴클레오타이드를 포함한다.
본 발명의 다른 일 구현예에 있어서, 상기 마커 조성물은 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열에서 101번째 염기에 위치한 SNP를 포함하는 적어도 10개의 연속적인 뉴클레오타이드를 포함하는 폴리뉴클레오타이드, 또는 이의 상보적인 폴리뉴클레오타이드를 추가적으로 포함한다.
상기 한국인 친족관계 확인용 마커 조성물은 상술한 다른 일 양태에 따른 한국인 친족관계 확인용 조성물이 포함하는 제제에 의해 증폭되거나 검출되는 SNP를 포함하므로, 이의 중복되는 내용은 본 명세서의 복잡성을 고려하여 생략한다.
본 발명의 다른 일 양태에 따르면, 본 발명은 상술한 한국인 친족관계 확인용 조성물을 포함하는 한국인 친족관계 확인용 키트를 제공한다.
본 발명의 일 구현예에 있어서, 상기 키트는 마이크로어레이(microarray)이다. 상기 키트는 염기서열분석(sequencing)에 사용될 수 있다.
상기 마이크로어레이는 상술한 SNP를 포함하는 폴리뉴클레오타이드, 또는 이의 상보적인 폴리뉴클레오타이드가 기판 표면 상의 구분된 영역에 고밀도로 배열된 형태일 수 있다. 구체적으로 상기 마이크로어레이는 표 2 및/또는 표 1의 서열번호 919 내지 서열번호 1400 및/또는 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 포함하는 적어도 10개의 연속된 뉴클레오타이드 서열, 또는 이의 상보적인 뉴클레오타이드 서열을 포함하는 폴리뉴클레오타이드가 고밀도로 배열된 형태일 수 있다.
상기 플로우 셀은 나노 단위의 지름을 갖는 웰(well)을 가진 글라스일 수 있다. 상기 웰에는 상술한 한국인 친족관계 확인용 조성물 내 SNP를 검출하거나 증폭할 수 있는 DNA 프로브를 포함하거나, 또는 상술한 SNP와 혼성화되는 프라이머가 부착되어 있다.
상기 키트는 상술한 SNP를 검출하거나 증폭하는 데에 필요한 시약, 예를 들어 dNTP, Taq DNA 중합효소, Φ29 DNA 중합효소와 같은 DNA 중합효소, 증류수, Tris-HCl, KCl(potassium chloride), MgCl2(magnesium chloride) 등을 추가적으로 포함할 수 있으나, 반드시 이에 제한되는 것은 아니다.
또한, 상기 키트는 상술한 SNP를 검출하거나 증폭하는 데에 필요한 장비, 예를 들어, 열순환기(thermocycler), PCR 장비, 염기서열분석기기(sequencer) 등을 추가적으로 포함할 수 있으나, 반드시 이에 제한되는 것은 아니다.
게다가, 상기 키트의 웰에 부착된 프라이머는 시료 중 SNP 또는 SNP에 연결된 어댑터와 혼성화되고, 그 혼성화 결과로부터 친족관계를 확인할 수 있다. 상기 키트는 시료 중 SNP 또는 SNP에 연결된 어댑터와 프라이머가 혼성화되는 데에 필요한 시약, 예를 들어, SNP를 포함하는 DNA 단편을 평활 말단으로 수선하기 위한 T4 DNA 중합효소, 클레나우 단편, T4 폴리뉴클레오타이드 인산화효소, A-테일링을 위한 dATP, SNP를 포함하는 DNA 단편에 어댑터를 라이게이션하기 위한 DNA 연결효소, 어댑터가 라이게이션된 DNA 단편을 증폭할 수 있는 인덱스 프라이머(index primer) 등을 추가적으로 포함할 수 있다.
상기 한국인 친족관계 확인용 키트는 상술한 다른 일 양태에 따른 한국인 친족관계 확인용 조성물을 포함하므로, 이의 중복되는 내용은 본 명세서의 복잡성을 고려하여 생략한다.
본 발명의 또 다른 일 양태에 따르면, 본 발명은 친족관계를 확인하고자 하는 2인 이상의 대상으로부터 분리된 시료에 대하여, 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP의 염기 종류를 확인하는 단계를 포함하는 한국인 친족관계 확인 방법을 제공한다.
SNP 위치에서 염기 종류, 즉 뉴클레오타이드 종류를 결정하는 방법은 당업계에서 공지되어 있는 방법, 예를 들어, 공지된 핵산의 염기서열분석 방법(sequencing method), 생어 염기서열분석(Sanger sequencing), 막삼-길버트 염기서열분석(Maxam-Gilbert Sequencing), 모세관 전기 영동 및 단편 분석법(Capillary electrophoresis and fragment analysis), 차세대 염기서열분석(next-generation sequencing, NGS) 방법 등이 사용될 수 있으나, 반드시 이에 제한되는 것은 아니다. 바람직하게는, SNP 위치에서 염기 종류는 차세대 염기서열분석(NGS)에 의해 결정되며, 관련 세부 사항은 기존 문헌(Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet. 2010 Jan;11(1):31-46.; Børsting C, Morling N. Next generation sequencing and its applications in forensic genetics. Forensic Sci Int Genet. 2015 Sep;18:78-89.; 및 Alvarez-Cubero MJ et al. Next generation sequencing: an application in forensic sciences? Ann Hum Biol. 2017 Nov;44(7):581-592.)을 참조할 수 있다.
또한, SNP 위치를 중심으로 20 bp 업스트림 및 20 bp 다운스트림 사이에 위치한 SNP를 포함하는 10 bp 내지 25 bp의 SNP 연접 서열(flanking sequence)에 상보적인 프로브 또는 프라이머를 대상 SNP를 포함하는 DNA 단편과 혼성화시키고, 혼성화 결과를 분석함으로써, SNP 위치의 뉴클레오타이드 종류를 결정할 수 있다.
본 발명의 일 구현예에 있어서, 상기 방법은 상기 친족관계를 확인하고자 하는 2인 이상의 대상으로부터 분리된 시료에 대하여, 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP의 염기 종류를 확인하는 단계를 추가적으로 포함한다.
본 발명의 일 구현예에 있어서, 상기 친족관계는 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나이다. 즉, 본 발명을 이용하는 경우 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계인 개체를 이들 관계가 아닌 개체로부터 구별할 수 있다.
본 발명의 다른 일 구현예에 있어서, 상기 친족관계는 본인을 기준으로 형제, 자매 및 남매 중 어느 하나이다. 즉, 본 발명을 이용하는 경우 형제, 자매 및 남매 중 어느 하나의 친족관계인 개체를 이들 관계가 아닌 개체로부터 구별할 수 있다. 본 발명에 따른 방법은 부모의 DNA 정보가 없는 경우에도 형제, 자매 및 남매 중 어느 하나의 친족관계인 개체를 이들 관계가 아닌 개체로부터 구별할 수 있다.
본 발명의 일 구현예에 있어서, 상기 SNP의 염기 종류를 확인하는 단계는 프라이머, 프로브, 또는 이들의 조합을 이용하여 SNP를 증폭 또는 검출하는 단계이다.
본 발명의 다른 일 구현예에 있어서, 상기 SNP의 염기 종류를 확인하는 단계는 시퀀싱용 올리고머 또는 프라이머를 이용하여 SNP를 증폭 또는 검출하는 단계이다.
본 발명의 일 구체예에 있어서, 상기 방법은 상기 SNP의 염기 종류를 확인하는 단계 이후 각 시료의 각 SNP 염기 종류를 서로 쌍으로(pairwise) 비교하는 단계를 추가적으로 포함한다.
본 발명의 일 구체예에 있어서, 상기 각 시료의 각 SNP 염기 종류를 서로 쌍으로(pairwise) 비교하는 단계는 당업계에 공지된 혈연관계 계수(kinship coefficient) 또는 근연도(coefficient of relatedness)를 계산하는 단계를 포함한다.
본 발명의 일 구체예에 있어서, 상기 혈연관계 계수 또는 근연도는 IBS(identity by state) scoring, IBD(identical by descent) scoring, 또는 우도비(likelihood ratio, LR)에 의해 계산될 수 있다. SNP 데이터로부터 IBD, IBS 및/또는 LR을 측정하고/계산하고 이로부터 혈연관계 계수 또는 근연도를 계산하는 방법은 여러 문헌(Frudakis T et al. A classifier for the SNP-based inference of ancestry. J Forensic Sci. 2003 Jul;48(4):771-82. Erratum in: J Forensic Sci. 2004 Sep;49(5):1145-6.; Stevens EL et al. Inference of relationships in population data using identity-by-descent and identity-by-state. PLoS Genet. 2011 Sep;7(9):e1002287.; Browning BL, Browning SR. A fast, powerful method for detecting identity by descent. Am J Hum Genet. 2011 Feb 11;88(2):173-82.; Zheng X et al. A high-performance computing toolset for relatedness and principal component analysis of SNP data. Bioinformatics. 2012 Dec 15;28(24):3326-8.; 및 Browning BL, Browning SR. Improving the accuracy and efficiency of identity-by-descent detection in population data. Genetics. 2013 Jun;194(2):459-71)에 개시된 내용을 참조할 수 있다.
본 발명에 따른 일 실시예에 기재된 바와 같이, Pedersen et al. 2020 (Somalier: rapid relatedness estimation for cancer and germline studies using efficient genome sketches. Genome medicine, 12(1), 1-9.)에 개시된 Somalier 프로그램을 이용하여 본 발명의 918개 및/또는 482개의 SNP 패널로부터 혈연관계 계수 또는 근연도 값을 추출할 수 있으나, 반드시 이에 제한되는 것은 아니며, 당업계에 공지된 SNP 데이터로부터 혈연관계 계수 또는 근연도 값을 구하는 방법이라면 본 발명에 적용될 수 있다.
본 발명의 일 구체예에 있어서, 상기 각 시료의 각 SNP 염기 종류를 서로 쌍으로(pairwise) 비교하는 단계는 다음 단계를 포함한다:
(a) i) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 동일한 경우 IBS 점수 2 (Identity by state 2)로 지정하거나, ii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 하나만 동일한 경우 IBS 점수 1로 지정하거나, 또는 iii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 상이한 경우 IBS 점수 0으로 지정하는 단계; 및
(b) 쌍으로 비교한 모든 상기 SNP에 대한 IBS 점수의 평균을 구하는 단계.
본 발명의 일 구체예에 있어서, 상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.310 내지 0.700인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계일 가능성이 있다는 정보를 제공하거나; 또는
상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.310 미만인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계가 아닐 가능성이 있다는 정보를 제공한다.
본 발명의 다른 일 구체예에 있어서, 상기 평균 IBS 점수가 0.340 내지 0.700인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계일 가능성이 있다는 정보를 제공하거나; 또는
상기 평균 IBS 점수가 0.340 미만인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계가 아닐 가능성이 있다는 정보를 제공한다.
상기 친족관계를 확인하고자 하는 대상은 2인일 수 있다. 상기 친족관계를 확인하고자 하는 대상은 2인 이상일 수 있다.
본 발명의 일 구현예에 있어서, 상기 친족관계를 확인하고자 하는 대상은 적어도 2인, 적어도 10인, 적어도 20인, 적어도 40인, 적어도 50인, 또는 적어도 100인이다. 본 발명의 다른 일 구현예에 있어서, 상기 친족관계를 확인하고자 하는 대상은 2인 내지 10인, 2인 내지 20인, 2인 내지 40인, 2인 내지 50인, 또는 2인 내지 100인이나, 반드시 이에 제한되는 것은 아니며, 이러한 기재는 친족관계를 확인하고자 하는 대상의 수를 제한하려는 의도가 아님을 당업자라면 이해할 것이다. 친족관계를 확인하고자 하는 대상에는 실종자, 불상 변사자, 부모가 생존해 있지 않은 상황에서의 신원 미상자, 전사자, 대형 재난에 의한 사상자, 사건 피해자, 유해, 이들의 유가족, 또는 이들의 후보 유가족이 포함되며, 필요에 따라 위에서 언급된 대상의 수보다 많은 수의 대상이 친족관계 확인 대상자가 될 수 있다.
또한, 사용하는 시퀀싱 플랫폼(sequencing platform)의 성능, 시퀀싱의 최종 아웃풋(Gb, giga base) 크기, 분석 대상 시료의 품질, 순도, DNA 수득률 등에 따라 친족관계를 확인하고자 하는 대상의 수가 결정될 수 있다. 상기 시퀀싱의 최종 아웃풋(Gb)은 사용자가 선택하는 앰플리콘(amplicon)의 수, 앰플리콘의 사이즈, 커버리지(coverage)에 따라 결정될 수 있다. 예를 들어, 시퀀싱의 최종 아웃풋이 약 1 Gb인 경우 친족관계를 확인하고자 하는 대상이 최소 10개체일 수 있으나, 반드시 이에 제한되는 것은 아니다. 다른 예를 들어, 한 개체로부터 얻은 혈액 시료에서 분리한 DNA의 순도 및 이의 수득율이 양호한 경우, 사용자는 시퀀싱의 최종 아웃풋을 작게 선택함으로써, 상기 개체와의 친족관계를 분석하고자 하는 대상의 개체 수를 증가시킬 수 있으며, 개체의 인덱싱(indexing) 조합을 선택하여 시퀀싱을 진행할 수 있다. 친족관계 확인의 목적이나 분석 대상 시료의 순도 및 수득율에 따라, 시퀀싱 최종 아웃풋 크기를 선택하거나, 적절한 성능의 시퀀싱 장비를 선택하거나, 또는 시퀀싱 실행 시간(running time)을 조절함으로써, 시퀀싱 품질을 조절할 수 있고, 결국 분석 가능한 개체의 수를 조절할 수 있다.
상기 대상은 인간이다. 상기 대상은 한국인이다. 상기 대상은 한반도의 원주민이나 거주자일 수 있고, 한반도 거주자가 아닌 한국인의 혈통을 가진 사람일 수 있다. 상기 대상은 실종자, 불상 변사자, 부모가 생존해 있지 않은 상황에서의 신원 미상자, 전사자, 대형 재난에 의한 사상자, 사건 피해자, 유해, 이들의 유가족, 또는 이들의 후보 유가족 등일 수 있으나, 반드시 이에 제한되는 것은 아니다.
상기 시료는 대상으로부터 분리된 세포, 조직(tissue), 기관(organ), 또는 체액(bodily fluid)일 수 있다. 상기 시료는 자연 상태에 방치된 것이거나, 오래된 유골과 같은 유해 시료이거나, 법의학 현장에서 수득한 시료이거나, 미라화된 조직과 같은 고고학적 시료이거나, 냉장 또는 냉동 보관된 것이거나, 포르말린과 같은 고정제로 고정된 것이거나, 파라핀으로 포매된 것이거나, 보존제가 처리된 것일 수 있다. 상기 시료에는 구강 스왑(swab), 질 스왑(vaginal swab), 직장 스왑(rectal swab), 타액, 땀, 소변, 분변, 점액, 정액, 혈액, 혈장, 혈청, 혈흔, 뇌척수액, 복수, 양수, 눈물, 분비물, 뼈, 등이 포함되나, 반드시 이에 한정되는 것은 아니다.
본 발명의 구체적인 일 구현예에 있어서, 상기 한국인 친족관계 확인 방법은 다음 단계를 포함한다:
1) 친족관계를 확인하고자 하는 적어도 2인의 한국인에서 DNA를 분리하는 단계;
2) 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열 또는 모든 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함하는 한국인 친족관계 확인용 조성물을 이용하여, 상기 분리한 DNA에서 SNP의 염기 종류를 확인하는 단계;
3) 다음 단계를 포함하는 각 시료의 각 SNP 염기 종류를 서로 쌍으로(pairwise) 비교하는 단계; 및
(a) i) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 동일한 경우 IBS 점수 2 (Identity by state 2)로 지정하거나, ii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 하나만 동일한 경우 IBS 점수 1로 지정하거나, 또는 iii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 상이한 경우 IBS 점수 0으로 지정하는 단계; 및
(b) 쌍으로 비교한 모든 상기 SNP에 대한 IBS 점수의 평균을 구하는 단계;
4) 상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.310 내지 0.700인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계일 가능성이 있다는 정보를 제공하거나; 또는
상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.310 미만인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계가 아닐 가능성이 있다는 정보를 제공하는 단계.
본 발명의 구체적인 다른 일 구현예에 있어서, 상기 한국인 친족관계 확인 방법은 다음 단계를 포함한다:
1) 친족관계를 확인하고자 하는 적어도 2인의 한국인에서 DNA를 분리하는 단계;
2) 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 전부 및 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함하는 한국인 친족관계 확인용 조성물을 이용하여, 상기 분리한 DNA에서 SNP의 염기 종류를 확인하는 단계;
3) 다음 단계를 포함하는 각 시료의 각 SNP 염기 종류를 서로 쌍으로(pairwise) 비교하는 단계; 및
(a) i) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 동일한 경우 IBS 점수 2 (Identity by state 2)로 지정하거나, ii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 하나만 동일한 경우 IBS 점수 1로 지정하거나, 또는 iii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 상이한 경우 IBS 점수 0으로 지정하는 단계; 및
(b) 쌍으로 비교한 모든 상기 SNP에 대한 IBS 점수의 평균을 구하는 단계;
4) 상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.310 내지 0.700인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매, 남매 중 어느 하나의 친족관계일 가능성이 있다는 정보를 제공하거나; 또는
상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.310 미만인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매, 남매 중 어느 하나의 친족관계가 아닐 가능성이 있다는 정보를 제공하는 단계.
본 발명의 구체적인 또 다른 일 구현예에 있어서, 상기 한국인 친족관계 확인 방법은 다음 단계를 포함한다:
1) 친족관계를 확인하고자 하는 적어도 2인의 한국인에서 DNA를 분리하는 단계;
2) 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 전부 및 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 전부에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 포함하는 한국인 친족관계 확인용 조성물을 이용하여, 상기 분리한 DNA에서 SNP의 염기 종류를 확인하는 단계;
3) 다음 단계를 포함하는 각 시료의 각 SNP 염기 종류를 서로 쌍으로(pairwise) 비교하는 단계; 및
(a) i) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 동일한 경우 IBS 점수 2 (Identity by state 2)로 지정하거나, ii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 하나만 동일한 경우 IBS 점수 1로 지정하거나, 또는 iii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 상이한 경우 IBS 점수 0으로 지정하는 단계; 및
(b) 쌍으로 비교한 모든 상기 SNP에 대한 IBS 점수의 평균을 구하는 단계;
4) 상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.300 내지 0.700인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매, 남매 중 어느 하나의 친족관계라는 정보를 제공하거나; 또는
상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.300 미만인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매, 남매 중 어느 하나의 친족관계가 아니라는 정보를 제공하는 단계.
본 발명의 또 다른 일 구현예에 있어서, 상기 한국인 친족관계 확인 방법은 다음 단계를 포함한다:
1) 친족관계를 확인하고자 하는 적어도 2인의 한국인에서 DNA를 분리하는 단계;
2) 상기 DNA에서 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열에서 101번째 염기에 위치한 SNP의 염기 종류를 확인하는 단계;
3) 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열에서 101번째 염기에 위치한 SNP 정보가 입력된 컴퓨터로 판독 가능한 매체에 상기 SNP의 염기 종류에 대한 데이터를 입력하는 단계;
4) 상기 컴퓨터로 판독 가능한 매체를 이용하여 두 명의 한국인 사이에서 평균 IBS 점수를 산출하는 단계;
5) 상기 평균 IBS 점수가 0.310 내지 0.700인 경우 두 명의 한국인이 서로 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계일 가능성이 있다는 정보를 제공하거나, 또는 상기 평균 IBS 점수가 0.310 미만인 경우 두 명의 한국인이 서로 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계가 아닐 가능성이 있다는 정보를 제공하는 단계.
상기 컴퓨터로 판독 가능한 매체는 온라인에서 접근 가능한 PLINK (http://zzz.bwh.harvard.edu/plink/)(Purcell et al. 2007), KING(Kinship-based Inference for Gwas)(https://www.kingrelatedness.com/) 등일 수 있으나, 반드시 이에 제한되는 것은 아니며, 입력된 SNP 패널 정보 및 DNA 시퀀싱 데이터로부터 혈연관계 계수 또는 근연도를 계산할 수 있는 것이라면, 제한없이 사용될 수 있다. 또한, 상기 컴퓨터로 판독 가능한 매체는 Somalier 프로그램(Pedersen et al. 2020)일 수 있다.
상기 컴퓨터로 판독 가능한 매체에 입력된 SNP 정보는 SNP가 위치하는 염색체 번호, 염색체상의 위치(position), dbSNP rs 번호와 같은 SNP의 고유 식별번호, SNP 위치에서 참조 유전체에 나타나는 참조 대립유전자(reference allele), SNP 위치에서 나타나는 선택적 대립유전자(alternative allele) 등이 포함될 수 있으나, 반드시 이에 제한되는 것은 아니다.
본 명세서에서, 용어 "참조 대립유전자(reference allele; ref. allele)"는 참조 유전체(reference genome)의 해당 좌위에서 발견되는 염기를 의미한다. 참조 대립유전자가 반드시 주요한 대립유전자임을 의미하는 것은 아니다.
본 명세서에서, 용어 "선택적 대립유전자(alternative allele; alt. allele)"는 해당 좌위에서 발견되는 위에서 정의한 참조 대립유전자와 상이한 종류의 임의의 염기를 의미한다.
상기 컴퓨터로 판독 가능한 매체는 입력된 918개 및/또는 482개 SNP 정보를 기반으로, 친족관계를 확인하고자 하는 적어도 2인의 한국인에서 분리한 DNA 시퀀싱 데이터를 쌍으로(pairwise) 비교하여, 즉 각 SNP 위치에서 염기 종류를 쌍으로 비교하여, IBS(identity by state), IBD(identical by descent), 또는 우도비(likelihood ratio, LR) 값을 산출한다. 상기 산출된 IBS, IBD, 또는 우도비 값으로부터 평균을 구하여 혈연관계 계수 또는 근연도 값을 추출한다.
본 발명의 한국인 친족관계 확인 방법을 단계별로 설명한다.
대상으로부터 분리된 시료에서 핵산을 분리하는 단계
상기 한국인 친족관계 확인 방법은 대상으로부터 분리된 시료에서 핵산을 분리하는 단계를 추가적으로 포함할 수 있다. 시료에서 핵산을 분리하는 방법은 당업계에 잘 알려진 방법, 예를 들어, Acid guanidinium thiocyanate-phenol-chloroform 추출 방법, PCI(phenol-chloroform-isoamyl alcohol) 용액을 이용한 추출 방법 등을 사용할 수 있으나, 반드시 이에 제한되는 것은 아니며, 관련 세부사항은 Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.(2001) 및 Haymes, B. D., 등, Nucleic Acid Hybridization, A Practical Approach, IRL Press, Washington, D.C. (1985)에 상세히 개시되어 있다. 대상으로부터 분리된 시료에서 핵산을 분리하기 위해 상업적으로 이용 가능한 핵산 추출 키트, 핵산 정제 키트 등이 사용될 수 있다. 상기 핵산은 정제 또는 품질관리(quality control) 과정을 추가적으로 또는 반복적으로 거칠 수 있다.
구체적으로, 대상으로부터 분리한 시료에서 유전체 DNA(genomic DNA)를 추출 및 정제하고, 품질 관리(quality control, QC)를 거친다. 상업적으로 이용 가능한 분광광도계(Spectrometer)나 형광계(Fluorometer), 예컨대 Thermo Scientific사의 NanoDrop, Qubit 등을 이용하여 추출한 DNA가 이중 가닥 DNA(double strand DNA)인지 확인하고, 추후 염기서열분석에 적절한 농도인지 확인하며, A260/280 비율 및 A260/230 비율을 조사해 DNA의 순도(purity)를 확인하고, 전기 영동을 통해 DNA가 분해(degradation)되었는지 여부 등 DNA 품질(quality)을 확인한다. 염기서열분석하는 데에 적합한 QC 기준을 통과한 DNA를 다음 라이브러리 제작에 사용한다. 당업계에 공지된 DNA 추출, 정제, QC 방법이라면 본 발명에서 제한없이 사용될 수 있다.
표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP의 염기 종류를 확인하는 단계
상기 SNP의 염기 종류를 확인하는 단계는 당업계에 공지된 DNA 증폭 방법, DNA 검출 방법, 염기서열분석(sequencing) 방법 등이라면 제한없이 사용될 수 있다. 염기서열분석 방법 중에서도 차세대 염기서열분석(NGS) 방법을 이용하는 것이 바람직하다.
이하, 상기 SNP의 염기 종류를 확인을 위한 염기서열분석 방법을 단계별로 설명한다.
(1) DNA 단편화
상술한 QC 기준을 통과한 DNA를 단편화(fermentation)한다. DNA 단편화는 당업계에 공지된 물리적 방법이나 효소를 이용한 화학적 방법으로 수행될 수 있다. 예를 들어, 전단력(shear force)을 가하여 DNA의 인산다이에스터 결합(phosphodiester linkages)을 끊는 물리적 방법으로는 음향 전단(acoustic shearing), 초음파 처리(sonication), 분무(nebulization), 유체 역학적 전단(hydrodynamic shearing) 등이 있고, 상업적으로 이용 가능한 Covaris사에서 제공하는 Adaptive Focused Acoustic® 기술, Diagenode사에서 제공하는 Bioruptor® DNA 전단 기술, DigiLab사에서 제공하는 HydroShear Plus Hydrodynamic DNA 전단 장비 등을 사용할 수 있으나, 반드시 이에 제한되는 것은 아니다.
또한, 효소 분해를 이용한 DNA 단편화에는 핵산내부가수분해효소(endonuclease) 및 절단효소(nicking enzyme)를 사용하여 DNA의 두 가닥을 자르거나 각 가닥에 틈(nick)을 발생시켜 이중 가닥 절단(double strand break)을 생성하는 방법 등이 있다. 효소 분해 시간을 조절하여 DNA 크기를 조절할 수 있다.
상술한 물리적 전단 및 효소 분해를 통한 DNA 단편화뿐만 아니라, 트랜스포존(transposon)을 이용한 DNA 단편화 방법 또한 사용될 수 있다(Adey A. et al., Genome Biol. 2010;11(12):R119.).
DNA 단편화 후 전기 영동을 통해 300 bp 내지 500 bp 크기의 DNA를 선택한다. DNA 단편화 후 QC를 추가적으로 수행할 수 있다.
(2) 말단 수선(End Repair) 및 A-테일링(A-Tailing)
위에서 수득한 단편화된 DNA의 손상된 말단, 즉 5' overhang 및 3'overhang을 T4 DNA 중합효소, 클레나우 단편 등을 이용하여 평활 말단(blunt end)으로 수선한다. 그 다음 평활 말단의 5' 말단을 T4 폴리뉴클레오타이드 인산화효소로 인산화하고, 3' 말단을 클레나우 단편 또는 Taq DNA 중합효소로 아데닐화, 즉 A-테일링한다. A-테일링은 추후 어댑터를 DNA에 연결하기 위해 필요하다.
(3) 어댑터 라이게이션(Adaptor ligation)
위에서 수득한 DNA 단편의 양 말단에 어댑터(adaptor)를 라이게이션하여 추후 염기서열분석에서 플로우 셀(flow cell)상의 올리고뉴클레오타이드가 어댑터를 인식할 수 있게 한다. 어댑터는 추후 DNA 증폭을 위해 프라이머가 어닐링되는 올리고뉴클레오타이드 쌍이다. DNA 단편에 결합되지 않은 어댑터나 어댑터 다이머(dimer)를 제거하기 위해 정제(clean-up) 과정을 추가적으로 수행할 수 있다.
(4) 라이브러리 제작 및 증폭
품질이 좋고 수득률이 높은 라이브러리를 제작하기 위해서는 가능한 적은 양부터 많은 양 까지의 DNA를 이용해서 DNA를 증폭하여야 하며, 적은 양의 DNA를 이용하였을 때도 수득률이 높은 라이브러리를 제작하여야 한다. PCR 오류가 추후 염기서열분석에서 오류를 발생시키므로, 가능한 적은 사이클(cycle)의 PCR을 수행하는 것이 바람직하고, 서열내 GC 함량(content)이나 AT 함량에 상관없이 균일성(uniformity)이 높은 PCR을 수행하기 위해 활성과 정확도(fidelity)가 높은 중합효소(polymerase)를 사용하여야 한다. 라이브러리 증폭은 어댑터에 결합하는 인덱스 프라이머(index primer)를 이용하여 수행될 수 있으며, 인덱스 프라이머는 싱글(single) 또는 듀얼(dual)일 수 있다.
위에서 어댑터를 라이게이션한 DNA의 라이브러리를 생성하기 위해 PCR을 이용하거나 이용하지 않고 수행될 수 있다. PCR을 이용하지 않는 DNA 라이브러리 증폭은 GC 함량 및 AT 함량이 높은 라이브러리를 생성하는데 주로 사용되는데 이는 많은 DNA 양이 요구되므로, 일반적으로 시료가 소량이거나 분해된(degraded) 핵산에서 라이브러리를 생성하기 위해서는 PCR을 이용하여 증폭한다. 그러나, 일반적인 PCR은 GC 편향(bias)을 일으키고, 이는 드 노보 유전체 조립(de novo sequencing)과 SNP 발견을 저해한다.
따라서, 본 발명자들은 이러한 PCR 오류 발생을 낮추기 위해 RCA(rolling circular amplicon)를 기반으로 하는 DNA 증폭 방법을 사용하였으나, 당업계에 공지된 증폭 오류 발생률이 낮은 DNA 증폭 방법이라면 제한되지 않고 사용될 수 있다.
구체적으로, RCA는 원형 DNA 또는 RNA를 빠르게 합성할 수 있는 단방향성(unidirectional) 핵산 복제 방법으로 이중 가닥 원형 DNA에서 틈(nick)이 있는 가닥에서 복제가 시작된다. 틈이 없는 가닥을 주형 가닥(template strand)으로 하여, 복제 결과 틈이 있는 단일-가닥 DNA를 분리하면서 연속적인 DNA 합성이 이루어지면, 긴 선형 단일-가닥의 연속적인 DNA 연쇄체(concatemer)가 생산된다.
RCA 기반 PCR을 위해, 위에서 어댑터를 라이게이션한 선형의 이중 가닥 DNA를 추가적으로 PCR로 증폭할 수 있다. PCR 증폭 후 QC를 추가적으로 수행할 수 있다.
본 발명의 일 실시예에서는 MGI사가 제공하는 상술한 RCA를 기반으로 하는 DNB(DNA nano ball, DNB) 염기서열분석 세트인 DNBSEQ-T7을 사용하였으나, 반드시 이에 제한되는 것은 아니며, 상업적으로 이용 가능한 염기서열분석 플랫폼, 예컨대 일루미나(illumine®) Nova-Seq, Thermo Fisher Scientific Ion TorrentTM, Helicos Biosciences tSMS(true Single Molecule Sequencing), PacBio SMRTTM(Single-molecule real time), GridIONTM, MinIONTM 등이라면 사용할 수 있음을 당업자라면 이해할 것이다.
위에서 수득한 선형의 이중 가닥 DNA인 PCR 산물을 선형의 단일 가닥 DNA로 열-변성시키고, DNA 연결효소(ligase)로 연결시켜 원형의 단일 가닥 DNA를 생성한다. 원형의 단일 가닥 DNA에 대한 QC를 추가적으로 수행할 수 있다. 제조사의 지시사항에 따라 수득한 원형의 단일 가닥 DNA에 DNA 나노 볼(DNB)을 제작을 위한 프라이머를 첨가한 후, RCA 반응을 수행한다. 수득한 DNB를 풀링(pooling)하고, 활성화 부위 당 오직 하나의 DNB(DNA nanoball)만 결합하는 MGI사의 고밀도 패턴화 나노어레이 플로우 셀을 이용하여 DNB 염기서열분석을 수행하였다.
(4) 염기서열분석
염기서열분석(sequencing, 시퀀싱, 유전체 해독)은 당업계에 공지된 방법으로 수행될 수 있으며, 도 9에 나타낸 WGS (whole genome sequencing) 분석 파이프라인 모식도와 같이 주요 단계를 거쳐 수행될 수 있다.
1) 염기서열 생성
염기서열분석 결과, DNA 단편에서 염기 서열이 식별되어 리드(read) 단위로 생성된다. 리드별로 각 염기에 대응하는 품질 지표인 프레드 품질 점수가 함께 생성되고, 이는 염기 서열 정보와 함께 FastQ 파일에 저장된다.
본 명세서에서, 용어 "프레드 품질 점수(Phred quality score)"는 각 염기(base)별 신뢰성을 표시한 품질 지표로, 한 개의 염기에서 오류가 발생할 확률을 예측한 값을 의미한다. 프레드 품질 점수는 염기서열분석 데이터에서 각 서열을 얼마나 정확하게 읽었는지 판단하는 기준으로 사용한다. 높은 점수를 나타낼수록 염기서열 검출(calling)이 더 정확할 가능성이 크다.
프레드 품질 점수(Q)는 다음의 식 1로부터 계산될 수 있다.
[식 1]
예를 들어, 한 개의 염기에서 오류가 발생할 확률이, 1/1000 및 1/10000이라면 프레드 품질 점수(Q)는 각각 Q30 및 Q40이다.
본 명세서에서, 용어 “리드(read)"는 염기서열분석 라이브러리에 포함된 DNA 또는 cDNA 단편에서 생성한 분석량에 대한 염기쌍 정보를 의미한다. 상기 리드는 염기서열분석 결과로 출력된 데이터, 시퀀스 또는 염기서열 조각을 포함한다.
본 명세서에서, 용어 “FastQ 파일"은 각 리드별 식별번호와 염기서열, 리드에 상응하는 품질 지표를 포함하는 파일을 의미한다.
다음으로, FastQ 파일의 품질을 평가한다. FastQ 파일의 품질을 평가할 수 있는 프로그램에는 FastQC, PRINSEQ, Trimmomatic 등이 있다.
본 발명의 일 실시예에서는 FastQC 프로그램을 이용하여 각 염기당 품질을 확인하여 문제 여부를 확인하였다. 또한, Cutadapt 프로그램(DOI:10.14806/ej.17.1.200.)을 이용하여 염기서열분석 리드에서 어댑터 서열을 제거하였으며, FastP를 이용하여 품질을 필터하기 위해 FastQ 데이터를 전-처리하였다. 서열 정렬 과정으로 넘어가기 전에 FastQC 프로그램을 이용하여 각 염기당 품질을 추가적으로 확인할 수 있다.
2) 서열 정렬
생성된 리드의 염기서열과 인간 참조 유전체의 염기서열을 정렬한다. 인간 참조 유전체는 GRCh 38 또는 GRCh 37을 사용할 수 있고, 이는 공공 데이터베이스에 개시되어 있다(GRCh 38, USCS version Hg19, https://hgdownload.cse.ucsc.edu/goldenPath/hg19/bigZips/; 및 GRCh 37, USCS version Hg38, https://hgdownload.cse.ucsc.edu/goldenPath/hg38/bigZips/). 서열을 정렬하여 해당 DNA 단편의 유전체상 원래 위치를 추정할 수 있다. BWA-MEM (Heng Li, 2013) 프로그램을 이용하여 참조 유전체에 대한 유사성에 기반하여 리드를 배열한다. 그 결과는 BAM 파일로 저장된다.
3) 중복 서열 제거
서열 정렬 후, PCR 중복 서열로 판단되는 리드를 Picard 프로그램을 이용하여 태그를 붙여 표시한다. 그 결과는 BAM 파일로 저장된다.
4) 염기 품질 점수 재교정(base quality score recalibration, BQSR)
GATK4 프로그램을 이용하여, 염기서열분석 장비가 계산한 각 염기의 품질 점수에 대해 기계학습 방법을 사용하여 오류 패턴을 감지하고 보정한다. 그 결과는 BAM 파일로 저장된다.
5) 품질 평가
서열 정렬 후 BAM 파일의 품질 평가를 수행하여, 염기서열분석을 수행한 개체의 진위 여부, 샘플링 및 라이브러리 제작의 이상 여부를 간접적으로 판단한다. 품질 평가에는 커버리지 깊이(depth of coverage), 평균 커버리지 깊이(mean depth of coverage), 중복 비율(duplication rate) 등이 있다. 커버리지 깊이는 목표 지점에 리드가 맵핑된 수를 의미한다. 중복 비율은 염기서열분석 중 PCR 과정에서 생기는 같은 DNA 단편인 PCR 중복 리드의 비율을 의미한다.
6) 변이 검출(variant calling)
참조 유전체와 생성된 서열 간의 차이점을 검출하여 변이를 검출한다. GATK4 프로그램에 BAM 파일을 입력하면 검출된 변이는 VCF 파일 포맷으로 저장된다. 본 명세서에서, 용어 “VCF(variant cell format) 파일"은 참조 유전체와 비교하여 상이하다고 판단된 변이와 그 빈도를 표시하는 표준 형식의 파일 포맷을 의미한다.
VCF 파일에는 변이가 위치한 염색체(chromosome), 염색체상 변이의 위치(position), dbSNP rs 번호와 같은 변이의 고유 식별번호, 변이 위치에서 참조 유전체에 나타나는 염기(REF), 선택적 대립 유전자(ALT, alternate allele, 즉 변이된 염기), 품질 점수, 변이에 표시된 필터명, 변이에 대한 추가적인 정보, 샘플 유전자형의 포맷 등의 정보가 포함되어 있다.
(5) 혈연관계 계수(kinship coefficient) 또는 근연도(coefficient of relatedness)의 추출
본 발명자들은 Somalier 프로그램(Pedersen et al. 2020)을 이용하여 기 추출된 BAM 파일로부터 918개 및/또는 482개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 계산하였다.
918개 및/또는 482개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 계산하는 방법은 당업계에 공지되어 있으며, 예를 들어, 다음과 같이 수행될 수 있다:
(a) i) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 동일한 경우 IBS 점수 2 (Identity by state 2)로 지정하거나, ii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 하나만 동일한 경우 IBS 점수 1로 지정하거나, 또는 iii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 상이한 경우 IBS 점수 0으로 지정하는 단계; 및
(b) 쌍으로 비교한 모든 상기 SNP에 대한 IBS 점수의 평균을 구하는 단계.
본 발명의 일 구현예에 있어서, 482개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 도출한 결과, 친족관계를 확인하고자 하는 두 개체 사이의 평균 IBS 점수가 0.310 내지 0.700의 버퍼(buffer) 영역에 위치하는 경우 두 개체가 서로 first degree relative 관계일 가능성이 있다는 정보를 제공하거나, 또는 두 개체 사이의 IBS 값이 0.310 미만인 경우 두 개체가 서로 first degree relative 관계가 아닐 가능성이 있다는 정보를 제공한다.
본 발명의 다른 일 구현예에 있어서, 482개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 도출한 결과, 친족관계를 확인하고자 하는 두 개체 사이의 평균 IBS 점수가 0.340 내지 0.700의 버퍼 영역에 위치하는 경우 두 개체가 서로 first degree relative 관계일 가능성이 있다는 정보를 제공하거나, 또는 두 개체 사이의 IBS 값이 0.340 미만인 경우 두 개체가 서로 first degree relative 관계가 아닐 가능성이 있다는 정보를 제공한다.
본 발명의 또 다른 일 구현예에 있어서, 482개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 도출한 결과, 친족관계를 확인하고자 하는 두 개체 사이의 평균 IBS 점수가 0.340 내지 0.620의 버퍼 영역에 위치하는 경우 두 개체는 서로 first-d-r 관계일 가능성이 있다는 정보를 제공하고, 두 개체 사이의 평균 IBS 점수가 0.175 내지 0.309의 버퍼 영역에 위치하는 경우 두 개체는 서로 second-d-r 관계일 가능성이 있다는 정보를 제공하며, 두 개체 사이의 평균 IBS 점수가 -0.277 내지 0.175의 버퍼 영역에 위치하는 경우 두 개체가 서로 관계가 없거나(unrelated) 또는 비친족 관계일 가능성이 있다는 정보를 제공한다.
본 발명의 여전히 다른 일 구현예에 있어서, 482개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 도출한 결과, 친족관계를 확인하고자 하는 두 개체 사이의 평균 IBS 점수가 0.378 내지 0.667의 버퍼 영역에 위치하는 경우 두 개체는 서로 first-d-r 관계일 가능성이 있다는 정보를 제공하고, 두 개체 사이의 평균 IBS 점수가 0.087 내지 0.414의 버퍼 영역에 위치하는 경우 두 개체는 서로 second-d-r 관계일 가능성이 있다는 정보를 제공하며, 두 개체 사이의 평균 IBS 점수가 0.270 이하의 영역(음의 IBS 값을 포함함)에 위치하는 경우 두 개체가 서로 관계가 없을 가능성이 있거나(unrelated) 또는 비친족 관계일 가능성이 있다는 정보를 제공한다.
본 발명에 따른 482개 SNP 마커를 이용하는 경우, first-d-r 관계에 있는 두 개체의 평균 IBS 점수와 second-d-r 관계에 있는 두 개체의 평균 IBS 점수가 위치하는 두 버퍼 영역이 서로 일부 겹치므로, 본인을 기준으로 first-d-r 관계인 개체와 second-d-r 관계인 개체를 구별하기에는 다소 제한적이나, 본인을 기준으로 first-d-r 관계에 있는 개체와 first-d-r 관계에 있지 않은 개체를 구별하는 데에는 유용하게 사용될 수 있다. 법과학 분야에서 두 개체가 가족관계라는 가능성을 배제할 수 없다는 증거는 유의한 의미를 가지며, 482개만의 최소한의 SNP를 서로 비교함으로써 남으로부터 first-d-r 관계에 있는 개체, 남으로부터 first-d-r 관계에 있을 가능성이 있는 개체, 또는 남으로부터 first-d-r 관계에 있을 가능성이 높은 개체를 구별할 수 있어 비용면에서 경제적이고, 친족관계 확인을 위한 시간을 단축시킬 수 있으므로, 본 발명에 따른 482개 SNP 마커는 법과학, 법의학, 또는 과학수사 분야에서 실용적이다.
본 발명의 일 구현예에 있어서, 918개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 도출한 결과, 친족관계를 확인하고자 하는 두 개체 사이의 평균 IBS 점수가 0.300 내지 0.700의 버퍼(buffer) 영역에 위치하는 경우 두 개체가 서로 first degree relative 관계라는 정보를 제공하거나, 또는 두 개체 사이의 IBS 값이 0.300 미만인 경우 두 개체가 서로 first degree relative 관계가 아니라는 정보를 제공한다.
본 발명의 다른 일 구현예에 있어서, 918개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 도출한 결과, 친족관계를 확인하고자 하는 두 개체 사이의 평균 IBS 점수가 0.380 내지 0.700의 버퍼 영역에 위치하는 경우 두 개체가 서로 first degree relative 관계라는 정보를 제공하거나, 또는 두 개체 사이의 IBS 값이 0.380 미만인 경우 두 개체가 서로 first degree relative 관계가 아니라는 정보를 제공한다.
본 발명의 또 다른 일 구현예에 있어서, 918개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 도출한 결과, 친족관계를 확인하고자 하는 두 개체 사이의 평균 IBS 점수가 0.382 내지 0.574의 버퍼 영역에 위치하는 경우 두 개체는 서로 first degree relative 관계라는 정보를 제공하고, 두 개체 사이의 평균 IBS 점수가 0.166 내지 0.299의 버퍼 영역에 위치하는 경우 두 개체는 서로 second degree relative 관계라는 정보를 제공하며, 두 개체 사이의 평균 IBS 점수가 -0.193 내지 0.144의 버퍼 영역에 위치하는 경우 두 개체가 서로 관계가 없거나(unrelated) 또는 비친족 관계라는 정보를 제공한다.
본 발명의 여전히 다른 일 구현예에 있어서, 918개 SNP 마커에 대한 변이로부터 두 개체 사이의 평균 IBS 점수를 도출한 결과, 친족관계를 확인하고자 하는 두 개체 사이의 평균 IBS 점수가 0.413 내지 0.635의 버퍼 영역에 위치하는 경우 두 개체는 서로 first degree relative 관계는 정보를 제공하고, 두 개체 사이의 평균 IBS 점수가 0.087 내지 0.378의 버퍼 영역에 위치하는 경우 두 개체는 second degree relative 관계는 정보를 제공하며, 두 개체 사이의 평균 IBS 점수가 0.273 이하의 영역(음의 IBS 값을 포함함)에 위치하는 경우 두 개체가 서로 관계가 없거나(unrelated) 또는 비친족 관계는 정보를 제공한다.
본 발명에 따른 918개 SNP 마커를 이용하는 경우, 종래 방법보다 적은 수의 SNP를 확인하여도, 심지어는 부모의 정보가 없는 경우에도, first degree relative 관계에 있는 두 개체의 평균 IBS 점수와 second degree relative 관계에 있는 두 개체의 평균 IBS 점수가 위치하는 버퍼 영역이 확연히 구분되므로, 즉 두 버퍼 영역이 서로 겹치지 않고 구별되므로, 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 하나인 first-d-r 관계인 개체와 first-d-r 관계가 아닌 개체를 명확하게 구별할 수 있다.
상술한 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 482개의 SNP 마커에 추가적으로 표 1의 서열번호 1 내지 서열번호 918에 나타낸 918개의 SNP 마커를 사용하는 경우, 친족관계 확인 분석의 정확도가 증가할 것으로 판단된다.
상기 한국인 친족관계를 확인 방법은 상술한 다른 일 양태에 따른 한국인 친족관계 확인용 조성물에 포함된 표 2의 서열번호 919 내지 서열번호 1400 및/또는 표 1의 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열에서 101번째 염기에 위치한 SNP 중 적어도 하나를 증폭 또는 검출하는 제제를 이용함으로써 실시되므로, 이의 중복되는 내용은 본 명세서의 복잡성을 고려하여 생략한다.
본 발명의 여전히 다른 일 양태에 따르면, 본 발명은 인간 유전체 데이터베이스에서 다음 중 적어도 하나의 특징을 나타내는 SNP를 추출하는 단계를 포함하는 친족관계 확인을 위한 SNP 마커 발굴 방법을 제공한다:
- 하디-바인베르크 평형(Hardy-Weinberg equilibrium, HWE)에서 p 값이 0.05 이상인 SNP;
- 유전자 영역 내 또는 유전자 영역의 100 kbp 업스트림 또는 다운스트림에 존재하지 않는 SNP;
- 대립유전자 빈도가 0.4 내지 0.6인 SNP;
- 연관 비평형에 존재하지 않는 SNP; 및
- 유전체 반복 영역에 존재하지 않는 SNP.
본 발명의 일 구현예에 있어서, 상기 인간 유전체 데이터베이스는 참조 유전체(reference genome)일 수 있다. 본 발명의 일 구체예에 있어서, 상기 참조 유전체는 염기서열분석이 완료되어 공공 데이터베이스로 구축되어 있는 표준 염기서열이다. 상기 참조 유전체는 GRCh37/hg19 또는 GRCh38/hg38일 수 있다.
본 발명의 다른 일 구현예에 있어서, 상기 인간 유전체 데이터베이스는 NCBI(National Center for Biotechnology Information)에서 제공하는 오픈 데이터베이스인 dbSNP(Single Nucleotide Polymorphism database)이다.
본 발명의 또 다른 일 구현예에 있어서, 상기 인간 유전체 데이터베이스는 한국인 참조 유전체일 수 있다. 상기 한국인 참조 유전체는 397명의 한국인 전장 유전체 염기서열(Whole genome sequence, WGS)(YJ et al., 2015), 한국인 200명의 전장 염기서열(Lee et al., 2017, 심혈관 질환 염기서열분석 연구), 또는 한국 표준 참조 변이체 데이터베이스(Korea National Standard Reference Variome database)인 코베리옴(KoVariome)에서 얻은 변이체(variome)이다.
당업자라면 본 발명에 따른 친족관계 확인을 위한 SNP 마커 발굴 방법을 참조하여 각 집단에 특이적인 친족관계 확인용 SNP 패널을 발굴할 수 있음을 이해할 것이다.
본 발명의 여전히 다른 일 구현예에 있어서, 상기 인간 유전체 데이터베이스는 각 집단(population), 예컨대, 유럽, 아프리카, 아프리카계 미국인, 아시아인, 동아시아인, 기타 아시아인, 라틴 아메리카, 남아시아인 등에 대한 참조 유전체(reference genome)일 수 있다.
예를 들어, 상기 인간 유전체 데이터베이스는 ALFA (Allele Frequency Aggregator), 일본인 참조 유전체 8.3KJPN, 세계 참조 유전체 (1000G, 1000 Genomes Project), 에스토니아인 참조 유전체 Estonian, 영국 브리스톨 주 출생 집단의 참조 유전체 ALSPAC (The Avon Longitudinal Study of Parents and Children), 영국 쌍둥이 참조 유전체TWINSUK, 한국인 참조 유전체 KOREAN, HGDP Stanford (The Human Genome Diversity Project), 햅맵 프로젝트 (HapMap), GoNL (Genome of the Netherlands), 스웨덴 참조유전체 NorthernSweden, SGDP PRJ (Simons Genome Diversity Project), 카타르 참조 유전체 QGP (Qatar Genome Program), 베트남 참조 유전체 Vietnamese, 고대 사르디니아인 참조 유전체 Ancient Sardinia, 덴마크 참조 유전체 GENOME DK, 또는 시베리아인 참조 유전체 Siberian일 수 있으나, 반드시 이에 제한되는 것은 아니다.
본 발명의 일 구현예에 있어서, 상기 하디-바인베르크 평형(Hardy-Weinberg equilibrium, HWE)은 NCBI의 dbGaP (database of Genotypes and Phenotypes)에 기탁된 GWAS (Genome-wide Association Study)에서 추출된 데이터 세트이다.
본 발명의 일 구현예에 있어서, 상기 대립유전자 빈도는 한국인 대립유전자 빈도일 수 있다. 본 발명의 일 구체예에 있어서, 상기 한국인 대립유전자 빈도는 코베리옴(KoVariome) 데이터베이스로부터 추출된 것이다.
본 발명의 일 구현예에 있어서, 상기 유전자 영역은 엑손(exon) 또는 코딩 서열(coding sequence)이다.
본 발명의 일 구현예에 있어서, 상기 연관 비평형에 존재하지 않는 SNP는 HaploReg v4.1 데이터베이스로부터 추출된 것이다. 본 발명의 일 구체예에 있어서, 상기 연관 비평형에 존재하지 않는 SNP는 상기 HaploReg v4.1 데이터베이스로부터 r2 값이 0.2 미만인 SNP가 추출된 것이다.
본 발명의 일 구현예에 있어서, 상기 유전체 반복 영역은 www.repeatmasker.org/species/hg.html에 개시된 영역이다.
상기 친족관계 확인을 위한 SNP 마커 발굴 방법의 결과로 상술한 다른 일 양태에 따른 한국인 친족관계 확인용 조성물을 도출하였으므로, 이의 중복되는 내용은 본 명세서의 복잡성을 고려하여 생략한다.
본 발명의 특징 및 이점을 요약하면 다음과 같다:
(a) 본 발명은 표 2의 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 단일염기다형성(single nucleotide polymorphism, SNP)을 증폭 또는 검출하는 제제를 포함하는 한국인 친족관계 확인용 조성물을 제공한다.
(b) 본 발명은 상술한 한국인 친족관계 확인용 조성물을 포함하는 한국인 친족관계 확인용 키트를 제공한다.
(c) 본 발명은 한국인 친족관계 확인 방법을 제공한다.
(d) 본 발명은 친족관계 확인을 위한 SNP 마커 발굴 방법을 제공한다.
(e) 본 발명의 한국인 친족관계 확인용 조성물을 이용하면, 대조 가능한 직계의 DNA를 얻을 수 없는 경우에도 최소한의 법의학적 SNP 마커 수로 한국인 집단에서 본인을 기준으로 first degree relative 관계일 가능성이 있는 개체와 first degree relative 관계가 아닐 가능성이 있는 개체를 명확하게 구분하는 데에 유용하게 사용할 수 있다.
도 1은 918개의 친족관계 확인용 SNP 마커를 발굴하기 위한 순서도를 나타낸다.
도 2는 482개의 친족관계 확인용 SNP 마커를 발굴하기 위한 순서도를 나타낸다.
도 3은 본 발명에 따른 918개 및 482개의 SNP 마커 위치를 표기한 염색체 개략도를 나타낸다.
도 4는 샘플 ID, NFS_202100101 내지 NFS_202100116에 대한 라이브러리 제작 QC 결과를 나타낸다.
도 5는 샘플 ID, NFS_202100117 내지 NFS_202100302에 대한 라이브러리 제작 QC 결과를 나타낸다.
도 6은 샘플 ID, NFS_202100303 내지 NFS_202100406에 대한 라이브러리 제작 QC 결과를 나타낸다.
도 7은 샘플 ID, NFS_202100407 내지 NFS_202100408에 대한 라이브러리 제작 QC 결과를 나타낸다.
도 8a 내지 8m은 50개체 염기서열분석 데이터의 염기 품질(base quality) 그래프를 나타낸다.
도 9는 WGS 분석 파이프라인 모식도를 나타낸다.
도 10은 918개의 SNP 마커를 이용한 40개체 IBS 테스트 결과 근연도 값 비교 매트릭스(matrix, 행렬)를 나타낸다.
도 11은 918개의 SNP 마커를 이용한 40개체 IBS 테스트 결과 근연도 값의 그룹별 비교 그래프를 나타낸다.
도 12는 918개의 SNP 마커를 이용한 50개체 IBS 테스트 결과 근연도 값 비교 매트릭스를 나타낸다.
도 13은 918개의 SNP 마커를 이용한 50개체 IBS 테스트 결과 근연도 값의 그룹별 비교 그래프를 나타낸다.
도 14는 482개의 SNP 마커를 이용한 40개체 IBS 테스트 결과 근연도 값 비교 매트릭스를 나타낸다.
도 15는 482개의 SNP 마커를 이용한 40개체 IBS 테스트 결과 근연도 값의 그룹별 비교 그래프를 나타낸다.
도 16은 482개의 SNP 마커를 이용한 50개체 IBS 테스트 결과 근연도 값 비교 매트릭스를 나타낸다.
도 17은 482개의 SNP 마커를 이용한 50개체 IBS 테스트 결과 근연도 값의 그룹별 비교 그래프를 나타낸다.
도 2는 482개의 친족관계 확인용 SNP 마커를 발굴하기 위한 순서도를 나타낸다.
도 3은 본 발명에 따른 918개 및 482개의 SNP 마커 위치를 표기한 염색체 개략도를 나타낸다.
도 4는 샘플 ID, NFS_202100101 내지 NFS_202100116에 대한 라이브러리 제작 QC 결과를 나타낸다.
도 5는 샘플 ID, NFS_202100117 내지 NFS_202100302에 대한 라이브러리 제작 QC 결과를 나타낸다.
도 6은 샘플 ID, NFS_202100303 내지 NFS_202100406에 대한 라이브러리 제작 QC 결과를 나타낸다.
도 7은 샘플 ID, NFS_202100407 내지 NFS_202100408에 대한 라이브러리 제작 QC 결과를 나타낸다.
도 8a 내지 8m은 50개체 염기서열분석 데이터의 염기 품질(base quality) 그래프를 나타낸다.
도 9는 WGS 분석 파이프라인 모식도를 나타낸다.
도 10은 918개의 SNP 마커를 이용한 40개체 IBS 테스트 결과 근연도 값 비교 매트릭스(matrix, 행렬)를 나타낸다.
도 11은 918개의 SNP 마커를 이용한 40개체 IBS 테스트 결과 근연도 값의 그룹별 비교 그래프를 나타낸다.
도 12는 918개의 SNP 마커를 이용한 50개체 IBS 테스트 결과 근연도 값 비교 매트릭스를 나타낸다.
도 13은 918개의 SNP 마커를 이용한 50개체 IBS 테스트 결과 근연도 값의 그룹별 비교 그래프를 나타낸다.
도 14는 482개의 SNP 마커를 이용한 40개체 IBS 테스트 결과 근연도 값 비교 매트릭스를 나타낸다.
도 15는 482개의 SNP 마커를 이용한 40개체 IBS 테스트 결과 근연도 값의 그룹별 비교 그래프를 나타낸다.
도 16은 482개의 SNP 마커를 이용한 50개체 IBS 테스트 결과 근연도 값 비교 매트릭스를 나타낸다.
도 17은 482개의 SNP 마커를 이용한 50개체 IBS 테스트 결과 근연도 값의 그룹별 비교 그래프를 나타낸다.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당업계에서 통상의 지식을 가진 자에 있어서 자명할 것이다.
실시예
본 명세서 전체에 걸쳐, 특정 물질의 농도를 나타내기 위하여 사용되는 "%"는 별도의 언급이 없는 경우, 고체/고체는 (중량/중량) %, 고체/액체는 (중량/부피) %, 그리고 액체/액체는 (부피/부피) %이다.
실시예 1. 본 발명의 친족관계 분석 방법 개요
법의학적으로 STR과 같은 마커를 기반으로 하는 친족 테스트가 현재 널리 사용되고 있다. 비록 약 105개 내지 106개의 SNP를 사용하면 더 높은 수준의 관련성을 추정할 수 있지만, 유전체 전체의 유전형 분석 및 SNP 분석은 법의학 사용에 비실용적일 수 있다. 따라서, 친족 분석을 위한 STR 분석 결과에 대한 보완적 분석을 위하여, 소량으로 관련성을 추정할 수 있는 SNP 마커를 발굴하는 것은 가치가 있다. 본 발명에서는 친족관계에 대한 정확한 분석을 위해 WGS를 원칙으로 관련성을 추정할 수 있는 SNP 마커를 추출하고 분석을 실시하였다.
유전적 관련성 확인에 필요한 최소한의 SNP를 발굴하여 향후 친족관계 확인에 필요한 SNP 패널을 생성하기 위해, 한국 표준 참조 변이체(KoVariome) 데이터베이스에 개시된 서로 관련이 없는 한국인 88명의 약 8천 4백만 개의 SNP로부터 한국인 집단에서 친족관계 확인을 위한 918개의 SNP 마커 및 482개의 SNP 마커를 발굴하였다.
본 발명자들은 발굴한 918개의 SNP 마커 및 482개의 SNP 마커를 이용해 한국인 친족관계를 확인하기 위해서, First degree relative, Second degree relative 및 Third degree relative 관계에 있는 90 개체의 한국인 집단에서 구강 스왑 또는 타액을 수집하였다. 상기 샘플로부터 DNA를 추출하고 염기서열분석(sequencing)을 수행하였다. 염기서열분석 장비인 Nova-Seq (Illumina사)을 이용해40개체의 WGS (Whole genome sequencing) 데이터를 생산하였다. Nova-Seq으로 생산된 40개체의 WGS 데이터와 50개체의 샘플을 ㈜클리노믹스(Clinomics Inc.)에 제공하여, DNBSEQ-T7(MGI사)를 이용한 48개체의 WGS 데이터 및 Nova-Seq을 이용한 2개체의 WGS 데이터를 수득하였다.
상술한 i) Nova-Seq으로부터 생산된 40개체의 WGS 데이터, 및 ii) DNBSEQ-T7으로부터 생산된 48개체의 WGS 데이터와 Nova-Seq으로 생산된 2개체의 WGS 데이터에서, 두 개체씩 쌍으로(pairwise) 비교하여 평균 IBS(Identity by state) 점수를 도출한 다음, First degree relative, Second degree relative, Third degree relative 및 unrelated(비친족 또는 관계없음) 그룹으로 나누고 평균 IBS 값을 비교함으로써, 본 발명의 SNP 마커를 이용한 한국인 친족관계 예측 분석을 수행하였다.
실시예 2. 한국인 친족관계 확인을 위한 SNP 마커 발굴 방법
상술하였듯이, 본 발명자들은 한국 표준 참조 변이체(KoVariome) 데이터베이스에 개시된 서로 관련이 없는, 즉 서로 친족관계가 아닌, 한국인 88명의 약 8천 4백만 개의 SNP로부터 한국인 친족관계 확인을 위한 SNP 마커를 발굴하였다(Kim J et al. Sci Rep. 2018).
2-1: 918개의 SNP 마커 발굴
친족 관계 확인을 위한 후보 SNP 마커를 선택하는 과정은 도 1에 나타낸 모식도의 순서대로 수행하였다.
2-1-1: 하디-바인베르크 평형에서 유전자좌 선택
먼저, SNP의 하디-바인베르크 평형(Hardy-Weinberg equilibrium, HWE)은 NCBI (National Center for Biotechnology Information)의 dbGaP (database of Genotypes and Phenotypes)에 기탁된 GWAS (Genome-wide Association Study)에서 추출되었다. SNP는 적어도 하나의 데이터 세트에서 HWE 테스트에 대한 p value가 0.05 보다 높은 것으로 추출되었다. 그 결과, 1,856,032개의 SNP를 추출하였다.
2-1-2: 유전자 영역 내 또는 근처 SNP 제외
그 후, SNP의 집단 빈도(population frequency)에 대한 선택 압력(selection pressure)의 잠재적인 영향을 피하기 위하여, 유전자 영역의 100 kbp 이내에 존재하는 SNP는 제거되었다. 질병의 유전 연구에는 표현형(phenotype)이 중요하므로, 엑손(exon) 연구가 이루어져야 하지만, 법과학수사에서의 유전적 특징의 연구는 특정 단백질을 지정하는 유전자일 경우 인권 침해의 소지가 있어, 연구나 감정 적용에서 배제되었다. 그 결과, 72,701개의 SNP를 추출하였다.
2-1-3: 코베리옴의 이형접합자를 사용한 SNP 유전자좌 추출
또한, 상술한 한국 표준 참조 변이체 데이터베이스(Korea National Standard Reference Variome database)인 코베리옴(KoVariome)에서 한국인 대립유전자 빈도가 약 0.5 (0.3 내지 0.7) 부근에 위치한 SNP를 추출하였다. 균형을 이룬 대립유전자 빈도는 임의의 2개의 관련이 없는 샘플에서 SNP가 서로 다를 확률을 극대화한다. 그 결과, 22,176개의 SNP를 추출하였다.
2-1-4: 연관 비평형에서 SNP 유전자좌 제외
연관 비평형(linkage disequilibrium, LD)에서 SNP를 제외하기 위해, HaploReg v4.1 데이터베이스를 이용하여 추출된 SNP의 r2 값이 0.2 이상인 SNP를 제거하였다(Ward & Kellis, 2016. 참조). 후보 SNP는 r2 값이 0.2 이상인 SNP 중에서 가장 왼쪽을 기반으로 하여 선택되었다. 그 결과, 1,516개의 SNP를 추출하였다.
2-1-5: 반복 영역에서 SNP 유전자좌 제외
마지막으로, 알려진 반복 영역(repeat region)에 존재하는 SNP를 제거하였다. 반복 영역의 SNP는 www.repeatmasker.org/species/hg.html에서 다운로드하였다 (hg38 - Dec 2013 - RepeatMasker open - 4.0.5 - Repeat Library 20140131). 최종적으로 918개의 SNP 패널을 발굴하였다.
한국인 친족 관계 확인을 위해 선별된 918개의 SNP는 아래 표 1에 나타내었으며, 101번째 염기에 각 SNP를 포함하는 201개의 뉴클레오타이드로 이루어진 서열을 서열번호 1 내지 서열번호 918에 각각 나타내었다. SNP의 염색체상 위치(position)는 인간 참조 유전체 GRCh38(Genome Reference Consortium Human Build 38; hg38)을 기준으로 나타내었고, 각 SNP는 101번째 염기 [n]에 참조 대립유전자(reference allele; ref. allele) 또는 선택적 대립유전자(alternative allele; alt. allele)가 위치할 수 있다. 또한, NCBI(National Center for Biotechnology Information)에서 제공하는 오픈 데이터베이스인 dbSNP(Single Nucleotide Polymorphism database)의 참조 SNP 클러스터 ID 숫자인 rs 번호(reference SNP cluster ID numbers; rs#)도 함께 기재하였다.
| 서열번호 | 염색체 번호 | 위치 (position) (GRCh38) |
Ref. Allele |
Alt. Allele B |
dbSNP rs# |
서열번호 | 염색체 번호 | 위치 (position) (GRCh38) |
Ref. Allele |
Alt. Allele B |
dbSNP rs# |
| 1 | 1 | 4281783 | C | T | rs1390136 | 460 | 3 | 5858280 | C | T | rs722615 |
| 2 | 1 | 4307966 | A | G | rs1817913 | 461 | 3 | 22484685 | A | T | rs6769828 |
| 3 | 1 | 4308891 | C | T | rs351617 | 462 | 3 | 22549447 | G | A | rs1463223 |
| 4 | 1 | 5193376 | G | A | rs12041491 | 463 | 3 | 26506852 | C | G | rs9820211 |
| 5 | 1 | 29598423 | T | C | rs915409 | 464 | 3 | 26836475 | C | T | rs7623573 |
| 6 | 1 | 30525732 | A | G | rs10915147 | 465 | 3 | 26837096 | A | C | rs11129244 |
| 7 | 1 | 34379235 | G | A | rs705197 | 466 | 3 | 26864096 | C | A | rs4443123 |
| 8 | 1 | 34478162 | G | A | rs10914958 | 467 | 3 | 26974564 | T | C | rs12487330 |
| 9 | 1 | 60258050 | A | C | rs1156177 | 468 | 3 | 26974902 | T | C | rs17019072 |
| 10 | 1 | 60410474 | T | C | rs7529292 | 469 | 3 | 30110652 | C | T | rs1032921 |
| 11 | 1 | 79651949 | A | G | rs4650425 | 470 | 3 | 30122198 | A | G | rs11715853 |
| 12 | 1 | 79767596 | C | T | rs3927739 | 471 | 3 | 30996454 | A | C | rs4624599 |
| 13 | 1 | 79771567 | T | G | rs12119501 | 472 | 3 | 35984485 | G | T | rs11129681 |
| 14 | 1 | 79783314 | A | C | rs12030273 | 473 | 3 | 61450901 | C | T | rs9872718 |
| 15 | 1 | 80890585 | A | G | rs12145866 | 474 | 3 | 74622030 | C | T | rs9840407 |
| 16 | 1 | 82095875 | T | G | rs962249 | 475 | 3 | 74787877 | C | G | rs1358345 |
| 17 | 1 | 82100386 | A | T | rs11163422 | 476 | 3 | 77912353 | G | T | rs11927310 |
| 18 | 1 | 83274975 | C | T | rs2538251 | 477 | 3 | 78402487 | A | G | rs9837024 |
| 19 | 1 | 83277034 | C | G | rs17101590 | 478 | 3 | 80320585 | C | T | rs7617987 |
| 20 | 1 | 83288496 | A | G | rs12120283 | 479 | 3 | 82565752 | C | A | rs13079811 |
| 21 | 1 | 91128933 | T | A | rs240510 | 480 | 3 | 95272414 | C | T | rs17384029 |
| 22 | 1 | 91139976 | G | A | rs653759 | 481 | 3 | 103369823 | G | A | rs4074892 |
| 23 | 1 | 91152839 | A | G | rs347026 | 482 | 3 | 103739235 | T | C | rs1379623 |
| 24 | 1 | 96123116 | T | G | rs2154010 | 483 | 3 | 104172135 | G | A | rs1104964 |
| 25 | 1 | 96931655 | C | T | rs17115963 | 484 | 3 | 104334184 | T | C | rs9809062 |
| 26 | 1 | 98376273 | T | C | rs7525553 | 485 | 3 | 105163092 | A | G | rs6770943 |
| 27 | 1 | 98462715 | A | G | rs4950129 | 486 | 3 | 105262407 | A | G | rs952365 |
| 28 | 1 | 104328360 | T | G | rs11809638 | 487 | 3 | 105972718 | G | T | rs13062596 |
| 29 | 1 | 104444439 | G | A | rs7520815 | 488 | 3 | 105976728 | T | C | rs2655033 |
| 30 | 1 | 104651212 | A | T | rs11184241 | 489 | 3 | 110087876 | G | T | rs13060275 |
| 31 | 1 | 106257917 | C | T | rs4301658 | 490 | 3 | 110389488 | C | T | rs2712965 |
| 32 | 1 | 118365750 | G | T | rs17038218 | 491 | 3 | 117241720 | G | A | rs12487249 |
| 33 | 1 | 165081809 | A | G | rs1494413 | 492 | 3 | 117296552 | T | C | rs11716697 |
| 34 | 1 | 187896223 | C | T | rs10912208 | 493 | 3 | 117358372 | A | G | rs1398641 |
| 35 | 1 | 187903620 | T | G | rs11591211 | 494 | 3 | 117437585 | A | C | rs3971401 |
| 36 | 1 | 188351784 | A | T | rs4282763 | 495 | 3 | 117438449 | A | G | rs16826930 |
| 37 | 1 | 188393167 | A | G | rs12039277 | 496 | 3 | 135739142 | T | C | rs1447600 |
| 38 | 1 | 189253831 | C | T | rs6700979 | 497 | 3 | 144290458 | G | A | rs6770845 |
| 39 | 1 | 191333287 | A | G | rs1246707 | 498 | 3 | 144558491 | T | C | rs2717389 |
| 40 | 1 | 195186500 | A | T | rs681013 | 499 | 3 | 144953465 | G | A | rs6779715 |
| 41 | 1 | 195189835 | A | T | rs4111374 | 500 | 3 | 145220841 | G | A | rs1348658 |
| 42 | 1 | 195600484 | C | T | rs10494727 | 501 | 3 | 146732481 | T | C | rs16858832 |
| 43 | 1 | 195863867 | A | G | rs7542834 | 502 | 3 | 147699834 | C | A | rs12639104 |
| 44 | 1 | 195885507 | G | A | rs921516 | 503 | 3 | 147705722 | A | G | rs2319306 |
| 45 | 1 | 199544437 | G | A | rs12045830 | 504 | 3 | 147713968 | T | C | rs9653947 |
| 46 | 1 | 199613744 | C | A | rs9628679 | 505 | 3 | 152945842 | A | G | rs2043854 |
| 47 | 1 | 208378428 | G | A | rs11119057 | 506 | 3 | 162705247 | C | T | rs7433221 |
| 48 | 1 | 208463524 | T | C | rs993324 | 507 | 3 | 162884798 | C | T | rs9823850 |
| 49 | 1 | 208855095 | T | C | rs12043779 | 508 | 3 | 176215977 | A | G | rs9848455 |
| 50 | 1 | 220997968 | G | A | rs2484696 | 509 | 3 | 182265049 | A | G | rs1542695 |
| 51 | 10 | 1847907 | C | A | rs17157139 | 510 | 3 | 187552363 | G | A | rs7645149 |
| 52 | 10 | 9140785 | G | A | rs12243321 | 511 | 3 | 189451891 | C | G | rs3896089 |
| 53 | 10 | 9417332 | T | C | rs12783041 | 512 | 3 | 189498378 | T | C | rs2600846 |
| 54 | 10 | 9559927 | T | A | rs7920503 | 513 | 3 | 191833690 | G | C | rs2138537 |
| 55 | 10 | 10563087 | C | T | rs2147291 | 514 | 3 | 193032457 | A | G | rs9831317 |
| 56 | 10 | 10596873 | C | T | rs972186 | 515 | 3 | 193040906 | G | A | rs6789557 |
| 57 | 10 | 10602864 | A | G | rs7089232 | 516 | 3 | 193041642 | A | G | rs9851295 |
| 58 | 10 | 10610702 | G | A | rs4749972 | 517 | 4 | 10917246 | G | T | rs16875484 |
| 59 | 10 | 29041960 | C | G | rs1335701 | 518 | 4 | 10959364 | G | T | rs11726335 |
| 60 | 10 | 29081550 | T | A | rs9664566 | 519 | 4 | 10959669 | G | A | rs7682428 |
| 61 | 10 | 29160200 | A | C | rs511991 | 520 | 4 | 11048220 | G | A | rs1110365 |
| 62 | 10 | 53190596 | A | G | rs2384170 | 521 | 4 | 11049711 | C | T | rs9291486 |
| 63 | 10 | 55847166 | A | G | rs1338788 | 522 | 4 | 11189846 | G | T | rs6835872 |
| 64 | 10 | 56745375 | A | G | rs7924028 | 523 | 4 | 11214614 | C | T | rs10009253 |
| 65 | 10 | 56867670 | A | G | rs11005565 | 524 | 4 | 13174346 | A | T | rs16888303 |
| 66 | 10 | 57408260 | A | G | rs11005792 | 525 | 4 | 18314369 | A | G | rs4140904 |
| 67 | 10 | 81367131 | C | A | rs649207 | 526 | 4 | 24008164 | T | G | rs624456 |
| 68 | 10 | 81404894 | C | A | rs7073999 | 527 | 4 | 24136516 | C | T | rs7663527 |
| 69 | 10 | 81406583 | A | G | rs2183174 | 528 | 4 | 24224295 | A | G | rs6820131 |
| 70 | 10 | 81545981 | A | G | rs17638653 | 529 | 4 | 24282415 | T | C | rs7663025 |
| 71 | 10 | 83169451 | G | T | rs11197616 | 530 | 4 | 24300108 | T | G | rs7664742 |
| 72 | 10 | 83560360 | C | T | rs11199196 | 531 | 4 | 27693271 | T | G | rs1031311 |
| 73 | 10 | 84662987 | A | G | rs11599612 | 532 | 4 | 28092597 | G | T | rs28539715 |
| 74 | 10 | 84705330 | C | G | rs2505778 | 533 | 4 | 30132426 | A | G | rs2571494 |
| 75 | 10 | 84828122 | G | A | rs7901050 | 534 | 4 | 30155271 | A | C | rs6824691 |
| 76 | 10 | 105411136 | G | A | rs12356045 | 535 | 4 | 30166358 | C | T | rs11930738 |
| 77 | 10 | 106306479 | T | A | rs821676 | 536 | 4 | 30387552 | T | A | rs41445348 |
| 78 | 10 | 120209055 | G | C | rs914483 | 537 | 4 | 30452690 | A | T | rs6833068 |
| 79 | 10 | 120248718 | C | T | rs12243526 | 538 | 4 | 32456905 | C | G | rs11935790 |
| 80 | 10 | 121292896 | A | C | rs12220387 | 539 | 4 | 34840072 | T | A | rs1467099 |
| 81 | 10 | 124231226 | G | A | rs28564851 | 540 | 4 | 35071923 | G | A | rs4859335 |
| 82 | 10 | 128420777 | C | T | rs1416722 | 541 | 4 | 35134580 | G | A | rs7684845 |
| 83 | 10 | 128487399 | C | T | rs1984218 | 542 | 4 | 35148038 | C | A | rs1023933 |
| 84 | 10 | 128520194 | C | T | rs11016297 | 543 | 4 | 35151566 | G | A | rs6852760 |
| 85 | 10 | 128523624 | C | T | rs11016304 | 544 | 4 | 35222908 | C | T | rs7691687 |
| 86 | 10 | 128549487 | G | C | rs10741157 | 545 | 4 | 35332851 | T | C | rs1530242 |
| 87 | 10 | 128549508 | T | C | rs4750710 | 546 | 4 | 35702700 | A | G | rs1035712 |
| 88 | 10 | 128554967 | A | G | rs7898393 | 547 | 4 | 45154996 | T | C | rs7654230 |
| 89 | 10 | 128685050 | A | G | rs12253697 | 548 | 4 | 45173787 | T | C | rs16858082 |
| 90 | 10 | 128712175 | A | G | rs7893266 | 549 | 4 | 45793878 | G | A | rs1492839 |
| 91 | 10 | 128745696 | A | G | rs7910094 | 550 | 4 | 45802030 | C | T | rs1389034 |
| 92 | 10 | 128749437 | C | G | rs11016458 | 551 | 4 | 57970497 | T | C | rs269829 |
| 93 | 10 | 128779321 | C | T | rs10829492 | 552 | 4 | 58289243 | C | T | rs17603347 |
| 94 | 10 | 129123978 | A | G | rs10741181 | 553 | 4 | 59294093 | C | A | rs7440334 |
| 95 | 10 | 129133073 | C | T | rs2123420 | 554 | 4 | 62963684 | T | G | rs2660605 |
| 96 | 10 | 129135480 | T | C | rs914570 | 555 | 4 | 62979085 | A | G | rs13123702 |
| 97 | 10 | 129149574 | A | G | rs10128422 | 556 | 4 | 66533925 | C | T | rs1995913 |
| 98 | 10 | 130792707 | A | G | rs7917491 | 557 | 4 | 66736552 | T | C | rs10005193 |
| 99 | 10 | 130804395 | C | T | rs12570660 | 558 | 4 | 66760731 | G | C | rs1947248 |
| 100 | 10 | 131519607 | G | A | rs10765078 | 559 | 4 | 67195915 | G | A | rs6815091 |
| 101 | 10 | 131562136 | T | C | rs10765092 | 560 | 4 | 67204598 | C | A | rs6841066 |
| 102 | 10 | 131660805 | A | C | rs4545466 | 561 | 4 | 71926132 | T | C | rs1520499 |
| 103 | 11 | 15354206 | C | T | rs11023541 | 562 | 4 | 72698088 | T | C | rs9291177 |
| 104 | 11 | 15354744 | C | G | rs7122143 | 563 | 4 | 85368167 | A | G | rs403870 |
| 105 | 11 | 24088370 | G | A | rs1317014 | 564 | 4 | 91762989 | G | A | rs6811317 |
| 106 | 11 | 24111009 | T | C | rs7121343 | 565 | 4 | 93939277 | C | T | rs2578139 |
| 107 | 11 | 36852864 | C | G | rs10501163 | 566 | 4 | 93962222 | T | C | rs1898636 |
| 108 | 11 | 37095265 | G | A | rs746517 | 567 | 4 | 95976372 | C | T | rs6823094 |
| 109 | 11 | 37124101 | T | C | rs2704917 | 568 | 4 | 95989085 | A | C | rs263075 |
| 110 | 11 | 37228417 | G | A | rs4756376 | 569 | 4 | 95995607 | G | A | rs7689809 |
| 111 | 11 | 39725355 | T | C | rs11035428 | 570 | 4 | 96040740 | C | T | rs1567957 |
| 112 | 11 | 39975331 | G | A | rs6485169 | 571 | 4 | 114368048 | A | G | rs4989308 |
| 113 | 11 | 79716863 | G | A | rs717100 | 572 | 4 | 114392159 | G | T | rs1962495 |
| 114 | 11 | 79772010 | T | G | rs2663205 | 573 | 4 | 115244948 | C | T | rs1112531 |
| 115 | 11 | 80091064 | C | A | rs570008 | 574 | 4 | 124823148 | G | A | rs1506556 |
| 116 | 11 | 95335790 | C | T | rs7125428 | 575 | 4 | 125019845 | C | G | rs2390770 |
| 117 | 11 | 97429250 | T | C | rs4755065 | 576 | 4 | 125019955 | T | C | rs1391392 |
| 118 | 11 | 97761882 | T | G | rs1828511 | 577 | 4 | 126260508 | T | C | rs10857112 |
| 119 | 11 | 98792099 | A | G | rs2169376 | 578 | 4 | 126320991 | C | A | rs2391038 |
| 120 | 11 | 113581871 | T | C | rs12365214 | 579 | 4 | 130605780 | C | T | rs7664241 |
| 121 | 11 | 114998713 | T | C | rs4489780 | 580 | 4 | 130700347 | C | G | rs41331449 |
| 122 | 11 | 116164654 | C | T | rs2844282 | 581 | 4 | 133370732 | T | C | rs6818278 |
| 123 | 11 | 116165087 | A | G | rs1783221 | 582 | 4 | 133763089 | G | T | rs17609744 |
| 124 | 11 | 116179554 | G | A | rs1783235 | 583 | 4 | 141890740 | C | T | rs1500842 |
| 125 | 11 | 116248195 | T | G | rs1009746 | 584 | 4 | 155008953 | G | A | rs6820565 |
| 126 | 11 | 116344392 | G | T | rs11601506 | 585 | 4 | 156246739 | C | T | rs7700147 |
| 127 | 11 | 116394352 | A | G | rs537538 | 586 | 4 | 159894529 | C | T | rs7672637 |
| 128 | 11 | 127812099 | T | C | rs1157862 | 587 | 4 | 159902822 | G | A | rs6849301 |
| 129 | 11 | 128346944 | C | T | rs4937324 | 588 | 4 | 160020695 | C | G | rs2711281 |
| 130 | 11 | 133651877 | A | G | rs10791302 | 589 | 4 | 160367917 | C | T | rs3846242 |
| 131 | 11 | 133661760 | C | T | rs11223548 | 590 | 4 | 160693235 | T | C | rs17359785 |
| 132 | 12 | 28684011 | T | C | rs7312487 | 591 | 4 | 160982953 | A | G | rs4260487 |
| 133 | 12 | 29968780 | T | C | rs16935137 | 592 | 4 | 164488143 | T | C | rs6834683 |
| 134 | 12 | 29972734 | C | G | rs1909174 | 593 | 4 | 166626278 | G | A | rs7673076 |
| 135 | 12 | 33096898 | A | G | rs1392331 | 594 | 4 | 167510453 | T | C | rs10517942 |
| 136 | 12 | 33234373 | G | A | rs7312915 | 595 | 4 | 176433799 | A | G | rs2122336 |
| 137 | 12 | 33252392 | T | C | rs7299903 | 596 | 4 | 178510860 | A | G | rs2614604 |
| 138 | 12 | 61052965 | T | C | rs1395540 | 597 | 4 | 178520937 | C | T | rs2715538 |
| 139 | 12 | 61054396 | G | C | rs7974374 | 598 | 4 | 178787228 | C | G | rs2044699 |
| 140 | 12 | 61338759 | A | G | rs2176199 | 599 | 4 | 178808271 | C | A | rs4862165 |
| 141 | 12 | 72881620 | G | A | rs6582124 | 600 | 4 | 179202114 | G | A | rs10028580 |
| 142 | 12 | 83277649 | T | C | rs7485422 | 601 | 4 | 179249214 | C | G | rs7435849 |
| 143 | 12 | 83464158 | C | T | rs11115877 | 602 | 4 | 179626828 | C | T | rs17775338 |
| 144 | 12 | 87368810 | G | A | rs7968713 | 603 | 4 | 179634825 | C | T | rs6834985 |
| 145 | 12 | 87537289 | C | T | rs11104542 | 604 | 4 | 179752080 | T | C | rs2100685 |
| 146 | 12 | 90407150 | G | A | rs7969733 | 605 | 4 | 180218268 | C | T | rs17068958 |
| 147 | 12 | 102625209 | T | C | rs7298152 | 606 | 4 | 180281999 | G | A | rs17069057 |
| 148 | 12 | 108015068 | C | G | rs1896061 | 607 | 4 | 180301728 | C | T | rs13109268 |
| 149 | 12 | 115466253 | T | C | rs721219 | 608 | 4 | 180367017 | T | C | rs2309249 |
| 150 | 13 | 22403650 | T | C | rs9510177 | 609 | 4 | 180391684 | G | A | rs6811892 |
| 151 | 13 | 22458981 | A | G | rs292476 | 610 | 4 | 180392768 | C | T | rs11734423 |
| 152 | 13 | 22460138 | A | T | rs2048148 | 611 | 4 | 180432579 | A | G | rs2309341 |
| 153 | 13 | 34804128 | C | T | rs9572437 | 612 | 4 | 180444072 | C | T | rs2727430 |
| 154 | 13 | 37323438 | G | A | rs2209245 | 613 | 4 | 180861463 | C | T | rs12644875 |
| 155 | 13 | 46999481 | A | G | rs12583882 | 614 | 4 | 180862831 | T | C | rs17070257 |
| 156 | 13 | 48872502 | T | C | rs9596029 | 615 | 4 | 181370290 | A | G | rs17246459 |
| 157 | 13 | 55282927 | C | T | rs9537053 | 616 | 5 | 2370332 | G | C | rs11949075 |
| 158 | 13 | 55704977 | A | G | rs8001026 | 617 | 5 | 2371828 | G | A | rs10036994 |
| 159 | 13 | 55748392 | G | T | rs1413111 | 618 | 5 | 2378722 | T | C | rs465850 |
| 160 | 13 | 55755583 | G | A | rs9597255 | 619 | 5 | 2398516 | A | C | rs650640 |
| 161 | 13 | 57831590 | G | C | rs9563541 | 620 | 5 | 2403330 | G | A | rs10059366 |
| 162 | 13 | 58631984 | A | G | rs9563622 | 621 | 5 | 2448046 | A | G | rs6555108 |
| 163 | 13 | 58880034 | G | A | rs17055603 | 622 | 5 | 2462244 | C | A | rs12655007 |
| 164 | 13 | 59364835 | A | G | rs1409254 | 623 | 5 | 2466470 | C | T | rs315918 |
| 165 | 13 | 61533404 | A | G | rs9563933 | 624 | 5 | 2468261 | C | A | rs924134 |
| 166 | 13 | 64197296 | A | C | rs4144113 | 625 | 5 | 2491471 | A | T | rs462437 |
| 167 | 13 | 65074363 | G | A | rs4306391 | 626 | 5 | 2491562 | T | C | rs16869827 |
| 168 | 13 | 65411117 | G | C | rs9571399 | 627 | 5 | 2493166 | A | C | rs2453814 |
| 169 | 13 | 66074646 | C | T | rs9540627 | 628 | 5 | 3068876 | A | T | rs2447672 |
| 170 | 13 | 68145856 | G | T | rs11148761 | 629 | 5 | 3756952 | T | C | rs13361372 |
| 171 | 13 | 68445189 | A | T | rs9564463 | 630 | 5 | 3779477 | A | G | rs6882956 |
| 172 | 13 | 70298257 | T | C | rs10161640 | 631 | 5 | 3799719 | G | A | rs4702464 |
| 173 | 13 | 70698715 | C | T | rs17087430 | 632 | 5 | 3856335 | C | T | rs12153260 |
| 174 | 13 | 72328053 | T | C | rs490599 | 633 | 5 | 4286823 | G | C | rs9313074 |
| 175 | 13 | 74682207 | C | T | rs9543745 | 634 | 5 | 5799874 | T | A | rs7703147 |
| 176 | 13 | 74703629 | C | T | rs1327740 | 635 | 5 | 5828535 | T | C | rs188684 |
| 177 | 13 | 74707684 | A | G | rs2104615 | 636 | 5 | 5887319 | G | T | rs1174922 |
| 178 | 13 | 74999239 | G | A | rs974510 | 637 | 5 | 5891765 | T | C | rs1174930 |
| 179 | 13 | 76281273 | C | T | rs2174452 | 638 | 5 | 12017153 | A | G | rs4544819 |
| 180 | 13 | 80235685 | A | C | rs17072502 | 639 | 5 | 12054151 | T | G | rs6862695 |
| 181 | 13 | 80472630 | T | C | rs944751 | 640 | 5 | 12060558 | T | C | rs10462685 |
| 182 | 13 | 81402764 | C | T | rs1334384 | 641 | 5 | 13358322 | C | T | rs4398634 |
| 183 | 13 | 81791630 | T | C | rs12429667 | 642 | 5 | 18337358 | T | G | rs10942113 |
| 184 | 13 | 82013133 | C | T | rs17174633 | 643 | 5 | 19337298 | T | C | rs2063564 |
| 185 | 13 | 82378443 | A | T | rs9601891 | 644 | 5 | 23155971 | G | T | rs310912 |
| 186 | 13 | 83398350 | T | C | rs4074473 | 645 | 5 | 23790902 | C | T | rs12186540 |
| 187 | 13 | 83766892 | A | G | rs1331944 | 646 | 5 | 25554641 | T | G | rs6885503 |
| 188 | 13 | 86564329 | A | C | rs9284259 | 647 | 5 | 26125530 | A | G | rs1330660 |
| 189 | 13 | 87992497 | G | T | rs11619659 | 648 | 5 | 26139251 | G | A | rs13154516 |
| 190 | 13 | 88341210 | A | C | rs1993354 | 649 | 5 | 26192988 | A | G | rs1411586 |
| 191 | 13 | 90657178 | T | C | rs12430684 | 650 | 5 | 26231825 | A | G | rs4604153 |
| 192 | 13 | 103175477 | G | A | rs2765584 | 651 | 5 | 26238085 | C | T | rs9293229 |
| 193 | 13 | 103179406 | T | C | rs9518946 | 652 | 5 | 27598430 | T | G | rs4235543 |
| 194 | 13 | 103722188 | G | T | rs4459430 | 653 | 5 | 27810333 | T | A | rs6864726 |
| 195 | 13 | 103730905 | G | A | rs1274749 | 654 | 5 | 27853422 | T | C | rs4128292 |
| 196 | 13 | 103944701 | A | G | rs2259614 | 655 | 5 | 28428784 | A | G | rs4867546 |
| 197 | 13 | 104007140 | C | T | rs1849445 | 656 | 5 | 30084498 | T | C | rs4867249 |
| 198 | 13 | 104245414 | A | G | rs9586450 | 657 | 5 | 30843732 | A | G | rs2066930 |
| 199 | 13 | 104335370 | A | G | rs1330527 | 658 | 5 | 30883945 | T | C | rs1921092 |
| 200 | 13 | 104357291 | G | C | rs9519304 | 659 | 5 | 30919759 | C | T | rs13356028 |
| 201 | 13 | 104358144 | A | G | rs9514252 | 660 | 5 | 34474631 | A | G | rs6451130 |
| 202 | 13 | 104511073 | C | T | rs7981507 | 661 | 5 | 44185810 | G | A | rs4293927 |
| 203 | 13 | 104598394 | G | T | rs2164080 | 662 | 5 | 50265025 | C | T | rs1328254 |
| 204 | 13 | 104623579 | C | T | rs7337127 | 663 | 5 | 51769467 | A | G | rs4391124 |
| 205 | 13 | 104630753 | A | C | rs496815 | 664 | 5 | 52383332 | A | C | rs4865730 |
| 206 | 13 | 104675786 | G | A | rs773350 | 665 | 5 | 52404601 | A | C | rs12521835 |
| 207 | 13 | 104680105 | G | T | rs773312 | 666 | 5 | 58277369 | A | G | rs37525 |
| 208 | 13 | 104916959 | G | A | rs7320561 | 667 | 5 | 62029131 | A | G | rs1833868 |
| 209 | 13 | 104947926 | C | T | rs9555118 | 668 | 5 | 62879988 | A | G | rs1402912 |
| 210 | 13 | 104986744 | T | C | rs9519543 | 669 | 5 | 62887158 | T | C | rs2222395 |
| 211 | 13 | 104987191 | T | C | rs9634456 | 670 | 5 | 63126263 | C | T | rs10039523 |
| 212 | 13 | 104987592 | T | A | rs9300980 | 671 | 5 | 63788359 | G | A | rs1478493 |
| 213 | 13 | 104989927 | C | A | rs9300981 | 672 | 5 | 63818580 | A | G | rs1478490 |
| 214 | 13 | 105211762 | A | G | rs3015350 | 673 | 5 | 68668261 | T | C | rs255257 |
| 215 | 13 | 105276911 | C | T | rs7989487 | 674 | 5 | 71949983 | T | C | rs1217744 |
| 216 | 13 | 105285190 | T | C | rs9519641 | 675 | 5 | 84682678 | G | A | rs6866089 |
| 217 | 13 | 105288707 | G | C | rs9301014 | 676 | 5 | 84707871 | T | G | rs10076429 |
| 218 | 13 | 108059883 | C | T | rs1325389 | 677 | 5 | 84722872 | C | T | rs4489064 |
| 219 | 13 | 111448590 | T | C | rs9560075 | 678 | 5 | 84722873 | A | G | rs4256345 |
| 220 | 14 | 26334093 | C | A | rs1956509 | 679 | 5 | 84823969 | G | T | rs7709606 |
| 221 | 14 | 27951885 | A | G | rs11624431 | 680 | 5 | 85956586 | C | A | rs12652144 |
| 222 | 14 | 27997327 | A | G | rs1888385 | 681 | 5 | 89788656 | T | C | rs819355 |
| 223 | 14 | 27997820 | C | T | rs2251721 | 682 | 5 | 91945393 | G | T | rs825388 |
| 224 | 14 | 27997930 | A | G | rs2775279 | 683 | 5 | 99701395 | G | T | rs7717666 |
| 225 | 14 | 27998525 | A | G | rs6575994 | 684 | 5 | 100260665 | G | A | rs326100 |
| 226 | 14 | 28018102 | T | C | rs1013379 | 685 | 5 | 101683566 | A | G | rs12654056 |
| 227 | 14 | 38497401 | A | G | rs11628255 | 686 | 5 | 103682011 | T | C | rs1152176 |
| 228 | 14 | 43762866 | T | C | rs1957280 | 687 | 5 | 103689757 | T | C | rs9632474 |
| 229 | 14 | 48944485 | G | A | rs2352906 | 688 | 5 | 103705903 | C | T | rs3906355 |
| 230 | 14 | 49189123 | G | A | rs8011197 | 689 | 5 | 103750446 | G | A | rs2161495 |
| 231 | 14 | 62252583 | A | T | rs1399523 | 690 | 5 | 105528850 | A | G | rs4128686 |
| 232 | 14 | 80077778 | A | G | rs1181353 | 691 | 5 | 106050008 | T | G | rs960931 |
| 233 | 14 | 82132173 | T | A | rs17116374 | 692 | 5 | 106649102 | T | G | rs6876851 |
| 234 | 14 | 82531231 | T | C | rs12435137 | 693 | 5 | 110030010 | A | G | rs2168308 |
| 235 | 14 | 83170173 | G | C | rs7152994 | 694 | 5 | 110033459 | G | T | rs4957850 |
| 236 | 14 | 83481552 | A | G | rs4243668 | 695 | 5 | 110088850 | T | C | rs10515411 |
| 237 | 14 | 83533399 | G | A | rs1241925 | 696 | 5 | 110161259 | T | G | rs4460176 |
| 238 | 14 | 83628044 | T | C | rs7144922 | 697 | 5 | 113890004 | T | C | rs1482377 |
| 239 | 14 | 84285197 | T | C | rs8019836 | 698 | 5 | 117146494 | T | C | rs7710231 |
| 240 | 14 | 84844447 | G | A | rs1483065 | 699 | 5 | 119788359 | C | A | rs2973940 |
| 241 | 14 | 85755382 | C | T | rs8009268 | 700 | 5 | 120894485 | T | C | rs9327172 |
| 242 | 14 | 86629516 | G | A | rs4899905 | 701 | 5 | 121469167 | A | G | rs6874603 |
| 243 | 15 | 37595807 | A | T | rs8023501 | 702 | 5 | 123742189 | C | T | rs17150698 |
| 244 | 15 | 37671684 | T | C | rs16965448 | 703 | 5 | 123801665 | T | C | rs407364 |
| 245 | 15 | 37795999 | A | G | rs4924192 | 704 | 5 | 123803526 | A | G | rs154293 |
| 246 | 15 | 46206243 | G | A | rs1897841 | 705 | 5 | 123868698 | T | G | rs330676 |
| 247 | 15 | 53233218 | C | T | rs10163018 | 706 | 5 | 129274581 | G | C | rs10064168 |
| 248 | 15 | 87152512 | A | G | rs11632375 | 707 | 5 | 129292101 | A | C | rs252668 |
| 249 | 15 | 87154857 | G | A | rs10152178 | 708 | 5 | 129292600 | C | G | rs252670 |
| 250 | 15 | 96948385 | T | C | rs1468626 | 709 | 5 | 136623362 | T | C | rs10051626 |
| 251 | 15 | 96973890 | C | T | rs11630458 | 710 | 5 | 143979881 | G | A | rs160870 |
| 252 | 16 | 17667817 | T | C | rs8053673 | 711 | 5 | 153341040 | G | A | rs11167629 |
| 253 | 16 | 25585119 | G | A | rs205163 | 712 | 5 | 161046366 | G | A | rs4921175 |
| 254 | 16 | 26938339 | G | T | rs9806926 | 713 | 5 | 161092424 | G | C | rs1387612 |
| 255 | 16 | 26946375 | T | C | rs11074811 | 714 | 5 | 161092556 | G | A | rs1387611 |
| 256 | 16 | 26950631 | G | A | rs12447485 | 715 | 5 | 162282821 | A | G | rs17060201 |
| 257 | 16 | 26963686 | T | G | rs4238945 | 716 | 5 | 163990363 | T | G | rs6860898 |
| 258 | 16 | 52816487 | A | G | rs16951610 | 717 | 5 | 166256592 | G | A | rs13163863 |
| 259 | 16 | 55149989 | C | T | rs1463632 | 718 | 5 | 166520830 | G | A | rs2961857 |
| 260 | 16 | 60154373 | T | C | rs929854 | 719 | 5 | 166639250 | T | G | rs347993 |
| 261 | 16 | 60757487 | T | G | rs11076411 | 720 | 5 | 171612618 | G | A | rs2879407 |
| 262 | 16 | 61270284 | G | T | rs16963190 | 721 | 5 | 175097385 | A | G | rs12109464 |
| 263 | 16 | 62702897 | C | T | rs4131140 | 722 | 5 | 175131495 | A | G | rs2248804 |
| 264 | 16 | 64047131 | T | C | rs16966908 | 723 | 5 | 175175435 | C | A | rs13169756 |
| 265 | 16 | 64842774 | G | T | rs1005822 | 724 | 5 | 175180838 | A | G | rs695221 |
| 266 | 16 | 66040422 | G | T | rs11075616 | 725 | 6 | 9398662 | C | T | rs214444 |
| 267 | 16 | 66061838 | G | A | rs7184941 | 726 | 6 | 15765518 | G | T | rs413080 |
| 268 | 16 | 75962058 | A | G | rs1498059 | 727 | 6 | 23229496 | G | C | rs13208665 |
| 269 | 16 | 82311978 | T | C | rs2906802 | 728 | 6 | 23506262 | A | G | rs199108 |
| 270 | 17 | 10990482 | A | C | rs7219444 | 729 | 6 | 40101697 | G | T | rs3008841 |
| 271 | 17 | 10995136 | A | G | rs758112 | 730 | 6 | 48314914 | T | G | rs614819 |
| 272 | 17 | 14595973 | C | G | rs8074338 | 731 | 6 | 48447416 | G | A | rs9395354 |
| 273 | 17 | 14604697 | T | A | rs11078260 | 732 | 6 | 50290485 | C | T | rs1361504 |
| 274 | 17 | 52642873 | C | T | rs2452236 | 733 | 6 | 51015810 | G | A | rs9357680 |
| 275 | 17 | 65356847 | G | A | rs6504297 | 734 | 6 | 51258411 | A | T | rs2465049 |
| 276 | 17 | 70471938 | G | C | rs4080890 | 735 | 6 | 51260442 | C | T | rs2465034 |
| 277 | 17 | 70883284 | A | G | rs17223678 | 736 | 6 | 61063311 | T | C | rs3863232 |
| 278 | 17 | 71399303 | G | A | rs917345 | 737 | 6 | 66291673 | A | C | rs2188585 |
| 279 | 17 | 71399807 | C | T | rs8071270 | 738 | 6 | 66320742 | G | T | rs6455096 |
| 280 | 18 | 4564126 | A | G | rs8095810 | 739 | 6 | 66837013 | A | G | rs4395708 |
| 281 | 18 | 4615729 | C | T | rs4372777 | 740 | 6 | 67314965 | C | T | rs9363740 |
| 282 | 18 | 25458254 | T | G | rs4800216 | 741 | 6 | 69490352 | G | A | rs1831196 |
| 283 | 18 | 25541579 | T | G | rs1627290 | 742 | 6 | 76194419 | A | G | rs4467744 |
| 284 | 18 | 28283384 | C | T | rs1548755 | 743 | 6 | 78709713 | A | G | rs10485127 |
| 285 | 18 | 29775114 | T | A | rs9635913 | 744 | 6 | 80660369 | G | A | rs2061044 |
| 286 | 18 | 29823325 | A | G | rs16947191 | 745 | 6 | 82770749 | A | G | rs4111785 |
| 287 | 18 | 29858338 | G | A | rs12960708 | 746 | 6 | 86541476 | A | G | rs952571 |
| 288 | 18 | 29923528 | T | C | rs12607637 | 747 | 6 | 90688053 | T | A | rs8180550 |
| 289 | 18 | 30517355 | G | T | rs41379044 | 748 | 6 | 90781546 | G | C | rs1145757 |
| 290 | 18 | 34330004 | A | G | rs12968586 | 749 | 6 | 90808976 | T | C | rs4707649 |
| 291 | 18 | 38092452 | C | A | rs9966896 | 750 | 6 | 90811724 | G | C | rs1394248 |
| 292 | 18 | 38127720 | C | T | rs4800001 | 751 | 6 | 90929095 | A | G | rs1016075 |
| 293 | 18 | 38380962 | C | T | rs958801 | 752 | 6 | 90929121 | A | T | rs1016074 |
| 294 | 18 | 38387518 | T | C | rs1511939 | 753 | 6 | 90929604 | C | T | rs1145807 |
| 295 | 18 | 38464762 | C | T | rs991045 | 754 | 6 | 90988142 | T | G | rs9353772 |
| 296 | 18 | 38465748 | C | T | rs10502693 | 755 | 6 | 91083391 | C | T | rs10944520 |
| 297 | 18 | 38474197 | C | T | rs5000343 | 756 | 6 | 91130011 | A | G | rs9362831 |
| 298 | 18 | 38474263 | C | T | rs2217109 | 757 | 6 | 91132198 | G | A | rs4128787 |
| 299 | 18 | 38482221 | T | A | rs9959302 | 758 | 6 | 91134791 | C | T | rs9345098 |
| 300 | 18 | 38483159 | C | T | rs12962345 | 759 | 6 | 94548200 | A | G | rs2208173 |
| 301 | 18 | 38795294 | G | T | rs9946289 | 760 | 6 | 94712496 | T | G | rs6911710 |
| 302 | 18 | 40350048 | T | A | rs16973135 | 761 | 6 | 95388320 | G | A | rs2890370 |
| 303 | 18 | 40375825 | A | C | rs2862365 | 762 | 6 | 98512999 | G | A | rs150394 |
| 304 | 18 | 40437661 | C | A | rs16973361 | 763 | 6 | 99749409 | G | A | rs7742890 |
| 305 | 18 | 40907143 | A | G | rs974309 | 764 | 6 | 102190424 | G | C | rs6902587 |
| 306 | 18 | 40944295 | C | A | rs1869282 | 765 | 6 | 102580272 | T | C | rs7758751 |
| 307 | 18 | 43386920 | C | T | rs684289 | 766 | 6 | 102853749 | C | T | rs1431222 |
| 308 | 18 | 51950685 | A | G | rs2953258 | 767 | 6 | 103705995 | A | T | rs4945935 |
| 309 | 18 | 53731968 | T | C | rs3906453 | 768 | 6 | 104288295 | G | A | rs201204 |
| 310 | 18 | 56327706 | C | T | rs12150697 | 769 | 6 | 112723118 | C | T | rs6920975 |
| 311 | 18 | 56382009 | T | C | rs216568 | 770 | 6 | 115749483 | T | C | rs9320547 |
| 312 | 18 | 61155719 | C | G | rs10513926 | 771 | 6 | 119496835 | T | C | rs9374799 |
| 313 | 18 | 64524418 | T | C | rs8092218 | 772 | 6 | 119563003 | G | A | rs1499564 |
| 314 | 18 | 64540623 | A | T | rs4531842 | 773 | 6 | 120117704 | G | T | rs1475164 |
| 315 | 18 | 65288133 | C | T | rs1505996 | 774 | 6 | 120188045 | T | C | rs155162 |
| 316 | 18 | 67255462 | A | G | rs11875127 | 775 | 6 | 121961831 | A | G | rs1521216 |
| 317 | 18 | 70783769 | A | G | rs17083161 | 776 | 6 | 122050973 | C | A | rs9372675 |
| 318 | 18 | 70826008 | A | T | rs12606536 | 777 | 6 | 137328957 | C | T | rs1145965 |
| 319 | 18 | 71340217 | A | G | rs1244840 | 778 | 6 | 137367252 | C | T | rs12212642 |
| 320 | 18 | 71373343 | T | C | rs334428 | 779 | 6 | 140320875 | T | C | rs12055615 |
| 321 | 18 | 72206367 | A | C | rs10871696 | 780 | 6 | 141121688 | A | G | rs4385332 |
| 322 | 18 | 72240489 | G | T | rs7232482 | 781 | 6 | 141132008 | T | C | rs7738388 |
| 323 | 18 | 72289278 | A | T | rs4530251 | 782 | 6 | 141848344 | C | T | rs9389952 |
| 324 | 18 | 72291789 | C | G | rs4891990 | 783 | 6 | 144959017 | G | A | rs9390266 |
| 325 | 18 | 72301864 | C | G | rs7230444 | 784 | 6 | 145049586 | T | C | rs2153143 |
| 326 | 18 | 72351642 | C | A | rs9949765 | 785 | 6 | 153788411 | A | G | rs12213446 |
| 327 | 18 | 72431957 | T | C | rs12456190 | 786 | 6 | 155755673 | C | T | rs2353784 |
| 328 | 18 | 72982202 | A | G | rs9951195 | 787 | 6 | 164449032 | A | G | rs9347854 |
| 329 | 18 | 73037239 | C | T | rs8093852 | 788 | 6 | 164553942 | A | G | rs9459136 |
| 330 | 18 | 73565234 | C | T | rs4892113 | 789 | 6 | 164564773 | G | A | rs4709863 |
| 331 | 18 | 73580087 | T | C | rs9967039 | 790 | 6 | 164642176 | G | T | rs8180617 |
| 332 | 18 | 77751986 | A | G | rs8090827 | 791 | 7 | 9344656 | T | A | rs12531647 |
| 333 | 18 | 77763393 | C | T | rs2727057 | 792 | 7 | 9348488 | A | G | rs17161591 |
| 334 | 18 | 78242654 | A | C | rs4458091 | 793 | 7 | 9494494 | T | C | rs2350850 |
| 335 | 18 | 78253589 | C | T | rs7239178 | 794 | 7 | 10342422 | T | C | rs6415296 |
| 336 | 18 | 78306845 | T | C | rs612097 | 795 | 7 | 19248756 | T | C | rs17140993 |
| 337 | 18 | 78650533 | A | G | rs2016252 | 796 | 7 | 41233817 | A | G | rs2051870 |
| 338 | 18 | 78671563 | G | A | rs4798975 | 797 | 7 | 41274867 | C | T | rs417916 |
| 339 | 18 | 78675166 | G | A | rs12605652 | 798 | 7 | 41275609 | T | A | rs452475 |
| 340 | 2 | 2433302 | A | G | rs7577250 | 799 | 7 | 41377410 | T | G | rs12701888 |
| 341 | 2 | 2522406 | G | A | rs10865530 | 800 | 7 | 41377669 | C | T | rs10267966 |
| 342 | 2 | 2529716 | C | G | rs11676482 | 801 | 7 | 41379974 | C | T | rs273085 |
| 343 | 2 | 2536520 | A | C | rs2037148 | 802 | 7 | 41470579 | T | A | rs273146 |
| 344 | 2 | 4242754 | A | G | rs17018897 | 803 | 7 | 42388980 | C | T | rs12530988 |
| 345 | 2 | 4246747 | T | G | rs1105752 | 804 | 7 | 42456896 | A | C | rs1123227 |
| 346 | 2 | 4281788 | G | A | rs6760082 | 805 | 7 | 42457429 | T | C | rs12673844 |
| 347 | 2 | 4359522 | C | A | rs2314218 | 806 | 7 | 49029150 | T | C | rs12718319 |
| 348 | 2 | 5414407 | G | A | rs12466470 | 807 | 7 | 49114242 | G | T | rs4486140 |
| 349 | 2 | 6106273 | G | A | rs6719357 | 808 | 7 | 49360186 | G | A | rs10227315 |
| 350 | 2 | 22649032 | G | A | rs1484679 | 809 | 7 | 51967064 | T | C | rs453828 |
| 351 | 2 | 35826675 | C | A | rs4109145 | 810 | 7 | 52372127 | G | A | rs3735071 |
| 352 | 2 | 36140420 | A | G | rs10174078 | 811 | 7 | 52720540 | T | C | rs9690428 |
| 353 | 2 | 40868073 | G | A | rs1379026 | 812 | 7 | 52726918 | T | C | rs1528995 |
| 354 | 2 | 41259375 | A | G | rs1991080 | 813 | 7 | 54080254 | A | G | rs12540328 |
| 355 | 2 | 41420114 | A | G | rs17027678 | 814 | 7 | 61089312 | G | A | rs13247259 |
| 356 | 2 | 41569117 | A | G | rs1975062 | 815 | 7 | 67472597 | G | C | rs11978872 |
| 357 | 2 | 41601181 | G | A | rs12989506 | 816 | 7 | 67901460 | G | T | rs10240492 |
| 358 | 2 | 53132207 | C | A | rs1900247 | 817 | 7 | 68477082 | T | A | rs6944505 |
| 359 | 2 | 53266121 | G | C | rs195611 | 818 | 7 | 68851831 | T | A | rs17670760 |
| 360 | 2 | 60213064 | G | C | rs11125832 | 819 | 7 | 71008019 | C | T | rs1525293 |
| 361 | 2 | 80980289 | G | A | rs10520291 | 820 | 7 | 81075164 | C | T | rs17154740 |
| 362 | 2 | 81766792 | A | G | rs1221175 | 821 | 7 | 83765933 | A | G | rs10249800 |
| 363 | 2 | 82114606 | C | T | rs1402774 | 822 | 7 | 83848354 | C | T | rs10487868 |
| 364 | 2 | 83323948 | G | C | rs6745924 | 823 | 7 | 84687890 | G | A | rs4278108 |
| 365 | 2 | 104271947 | A | C | rs12992682 | 824 | 7 | 86322767 | G | A | rs6977312 |
| 366 | 2 | 116040546 | G | A | rs1842420 | 825 | 7 | 97307465 | G | A | rs2394621 |
| 367 | 2 | 117641566 | A | C | rs2048819 | 826 | 7 | 109098880 | A | G | rs7806371 |
| 368 | 2 | 118461803 | G | T | rs7566562 | 827 | 7 | 113314158 | G | A | rs10240906 |
| 369 | 2 | 118535500 | C | T | rs11674141 | 828 | 7 | 113596455 | T | A | rs2462671 |
| 370 | 2 | 118641592 | C | G | rs1349459 | 829 | 7 | 113653136 | A | G | rs6962827 |
| 371 | 2 | 123177446 | G | A | rs6734319 | 830 | 7 | 114796071 | T | C | rs4366023 |
| 372 | 2 | 128684458 | T | C | rs28608534 | 831 | 7 | 115334141 | T | A | rs7777244 |
| 373 | 2 | 128718773 | C | T | rs6431023 | 832 | 7 | 126066219 | C | T | rs6958891 |
| 374 | 2 | 128745702 | T | G | rs10168422 | 833 | 7 | 145433787 | A | G | rs850398 |
| 375 | 2 | 128783968 | C | T | rs12473285 | 834 | 7 | 153040171 | T | C | rs6464300 |
| 376 | 2 | 133698922 | G | A | rs6430444 | 835 | 7 | 153245595 | C | T | rs1882828 |
| 377 | 2 | 133825743 | T | C | rs6430460 | 836 | 8 | 5242887 | G | C | rs6558984 |
| 378 | 2 | 133866705 | T | C | rs4603824 | 837 | 8 | 20800719 | C | T | rs7000415 |
| 379 | 2 | 133900169 | C | A | rs1446732 | 838 | 8 | 34451965 | A | G | rs958085 |
| 380 | 2 | 136648001 | C | T | rs1823084 | 839 | 8 | 34666892 | G | A | rs7464104 |
| 381 | 2 | 137816741 | A | G | rs7581781 | 840 | 8 | 34666961 | T | C | rs4455823 |
| 382 | 2 | 139076454 | A | T | rs10445695 | 841 | 8 | 41137620 | C | T | rs4736795 |
| 383 | 2 | 142244191 | T | C | rs12463449 | 842 | 8 | 41139405 | A | G | rs13273599 |
| 384 | 2 | 142660801 | C | A | rs2126000 | 843 | 8 | 41139982 | G | C | rs4736924 |
| 385 | 2 | 146043609 | A | G | rs10803514 | 844 | 8 | 51115453 | A | G | rs7824553 |
| 386 | 2 | 147032717 | A | G | rs16826756 | 845 | 8 | 59239001 | C | T | rs4237030 |
| 387 | 2 | 147254218 | T | G | rs2890872 | 846 | 8 | 77126826 | C | T | rs10095813 |
| 388 | 2 | 147600976 | C | T | rs12612855 | 847 | 8 | 77639021 | T | C | rs748 |
| 389 | 2 | 150752251 | A | G | rs10497071 | 848 | 8 | 83525360 | C | A | rs4418335 |
| 390 | 2 | 150876465 | A | G | rs12618428 | 849 | 8 | 88994211 | G | A | rs1994441 |
| 391 | 2 | 152992091 | T | C | rs16831993 | 850 | 8 | 97462688 | A | G | rs6995779 |
| 392 | 2 | 155831263 | T | C | rs1829525 | 851 | 8 | 97507691 | G | A | rs11784202 |
| 393 | 2 | 155909118 | T | C | rs16839725 | 852 | 8 | 106874764 | T | C | rs7827343 |
| 394 | 2 | 162971605 | T | C | rs1345959 | 853 | 8 | 107748427 | A | G | rs7005234 |
| 395 | 2 | 162974977 | G | T | rs7599823 | 854 | 8 | 110219023 | T | C | rs2350886 |
| 396 | 2 | 163441348 | C | A | rs7574166 | 855 | 8 | 113719319 | C | T | rs1377226 |
| 397 | 2 | 166720864 | G | A | rs11887539 | 856 | 8 | 113778550 | T | C | rs7000988 |
| 398 | 2 | 175564852 | A | G | rs9287985 | 857 | 8 | 115236105 | A | T | rs2980415 |
| 399 | 2 | 180107615 | A | G | rs2056785 | 858 | 8 | 115237679 | G | A | rs12677395 |
| 400 | 2 | 180132415 | G | A | rs12464448 | 859 | 8 | 117650318 | T | C | rs1508569 |
| 401 | 2 | 180133957 | T | C | rs7606018 | 860 | 8 | 121223780 | C | T | rs12542986 |
| 402 | 2 | 183714705 | T | C | rs13422535 | 861 | 8 | 122302054 | C | T | rs7012904 |
| 403 | 2 | 184485875 | G | A | rs1992514 | 862 | 8 | 131608452 | A | G | rs277037 |
| 404 | 2 | 185061558 | G | C | rs17584976 | 863 | 8 | 137215832 | A | C | rs4909357 |
| 405 | 2 | 191526144 | G | A | rs11889710 | 864 | 8 | 139229983 | C | T | rs12543243 |
| 406 | 2 | 192322055 | C | T | rs4853669 | 865 | 8 | 139285847 | C | G | rs7829324 |
| 407 | 2 | 192400180 | T | C | rs33957851 | 866 | 8 | 139324635 | C | A | rs4736071 |
| 408 | 2 | 192468221 | A | G | rs1385350 | 867 | 8 | 139342742 | C | T | rs4736253 |
| 409 | 2 | 192517040 | A | G | rs11886140 | 868 | 8 | 139345969 | A | G | rs6980509 |
| 410 | 2 | 192877352 | T | C | rs2218495 | 869 | 9 | 1436134 | T | C | rs876977 |
| 411 | 2 | 193379097 | G | T | rs4420715 | 870 | 9 | 1654460 | T | C | rs771901 |
| 412 | 2 | 195131352 | T | C | rs13383422 | 871 | 9 | 8090484 | T | C | rs12237393 |
| 413 | 2 | 195170744 | G | A | rs7583521 | 872 | 9 | 11129139 | T | C | rs10809353 |
| 414 | 2 | 220956193 | A | G | rs11682003 | 873 | 9 | 12402842 | A | G | rs2773858 |
| 415 | 2 | 221060913 | G | A | rs4672993 | 874 | 9 | 20096360 | C | T | rs10757118 |
| 416 | 2 | 221818216 | A | C | rs2551201 | 875 | 9 | 20178682 | C | T | rs1413254 |
| 417 | 2 | 225188804 | G | A | rs12694656 | 876 | 9 | 24298510 | A | C | rs6475790 |
| 418 | 2 | 225217439 | A | G | rs6736537 | 877 | 9 | 24707196 | C | T | rs16908722 |
| 419 | 2 | 225250729 | G | A | rs7571208 | 878 | 9 | 24717138 | T | A | rs16908747 |
| 420 | 2 | 226546643 | A | C | rs962171 | 879 | 9 | 24750181 | T | G | rs7849050 |
| 421 | 2 | 235303360 | A | G | rs1367876 | 880 | 9 | 24769580 | A | C | rs4319187 |
| 422 | 2 | 235336266 | C | G | rs6414039 | 881 | 9 | 25212651 | G | A | rs1412517 |
| 423 | 2 | 235392731 | G | A | rs10201495 | 882 | 9 | 25297842 | C | A | rs1156347 |
| 424 | 20 | 6956198 | C | T | rs6077109 | 883 | 9 | 26222210 | G | A | rs1369203 |
| 425 | 20 | 7472688 | T | C | rs4813827 | 884 | 9 | 26333944 | T | C | rs1336466 |
| 426 | 20 | 12030641 | T | G | rs13037930 | 885 | 9 | 26359487 | C | T | rs915508 |
| 427 | 20 | 12030723 | A | G | rs6109233 | 886 | 9 | 26457172 | T | C | rs1328425 |
| 428 | 20 | 12030940 | A | G | rs2327592 | 887 | 9 | 27723715 | G | A | rs2026147 |
| 429 | 20 | 12044061 | A | G | rs1997810 | 888 | 9 | 27724118 | G | A | rs13286192 |
| 430 | 20 | 12488857 | C | A | rs8182799 | 889 | 9 | 29022154 | C | T | rs10968887 |
| 431 | 20 | 12675520 | T | C | rs6134626 | 890 | 9 | 29434259 | T | A | rs1888817 |
| 432 | 20 | 12744370 | C | G | rs6041591 | 891 | 9 | 31837336 | A | G | rs10511887 |
| 433 | 20 | 24783547 | C | T | rs226665 | 892 | 9 | 31873013 | G | A | rs943926 |
| 434 | 20 | 39449471 | C | T | rs16988070 | 893 | 9 | 31895375 | A | G | rs10970585 |
| 435 | 20 | 40241479 | T | C | rs1980593 | 894 | 9 | 38250852 | G | A | rs12337623 |
| 436 | 20 | 40242000 | G | C | rs2870432 | 895 | 9 | 73280787 | T | C | rs10125086 |
| 437 | 20 | 40284166 | G | A | rs16988918 | 896 | 9 | 74109040 | A | G | rs10869324 |
| 438 | 20 | 40354288 | T | C | rs10485671 | 897 | 9 | 74172675 | A | G | rs966266 |
| 439 | 20 | 41821595 | A | T | rs6093527 | 898 | 9 | 78467599 | C | T | rs12351660 |
| 440 | 20 | 51252774 | A | G | rs1007126 | 899 | 9 | 78863824 | C | A | rs6559423 |
| 441 | 20 | 54960007 | T | G | rs928165 | 900 | 9 | 78893663 | G | A | rs4877311 |
| 442 | 20 | 55178061 | T | C | rs11086494 | 901 | 9 | 78900517 | C | T | rs1347815 |
| 443 | 20 | 55266878 | C | T | rs6069223 | 902 | 9 | 80144393 | G | A | rs10512097 |
| 444 | 20 | 56887842 | G | A | rs4810051 | 903 | 9 | 80223270 | C | A | rs617941 |
| 445 | 21 | 16974047 | G | C | rs8134480 | 904 | 9 | 80972229 | G | T | rs10780476 |
| 446 | 21 | 17089525 | C | T | rs2223079 | 905 | 9 | 81175482 | C | T | rs2777678 |
| 447 | 21 | 20005235 | T | C | rs2825938 | 906 | 9 | 103799644 | A | C | rs988692 |
| 448 | 21 | 22699093 | T | G | rs1513732 | 907 | 9 | 103801174 | G | T | rs7046401 |
| 449 | 21 | 23592329 | A | T | rs975592 | 908 | 9 | 108510416 | C | A | rs28615905 |
| 450 | 21 | 24647980 | G | T | rs2829220 | 909 | 9 | 118200004 | A | G | rs12551731 |
| 451 | 21 | 24662659 | G | C | rs2829240 | 910 | 9 | 118248454 | G | A | rs2149010 |
| 452 | 21 | 24737242 | G | A | rs2829310 | 911 | 9 | 118315750 | A | G | rs10124323 |
| 453 | 21 | 27247990 | C | G | rs2830800 | 912 | 9 | 118319036 | C | T | rs7047454 |
| 454 | 21 | 27251036 | A | G | rs2830802 | 913 | 9 | 118559223 | A | G | rs7036491 |
| 455 | 22 | 34348079 | T | C | rs204276 | 914 | 9 | 118563946 | G | A | rs4294251 |
| 456 | 3 | 5556979 | T | C | rs1430005 | 915 | 9 | 118870424 | T | C | rs4145935 |
| 457 | 3 | 5584074 | G | A | rs6765805 | 916 | 9 | 119680227 | A | G | rs6415829 |
| 458 | 3 | 5678174 | G | A | rs1545506 | 917 | 9 | 120076996 | G | A | rs7870808 |
| 459 | 3 | 5760199 | G | A | rs1836577 | 918 | 9 | 124137173 | G | A | rs2638384 |
2-2: 482개의 SNP 마커 발굴
위에서 추출한 918개의 SNP 마커의 개수를 더 줄이기 위하여, 한국인 집단에서 대립유전자 빈도가 약 0.4 내지 0.6 사이에 존재하는 SNP만을 추출한 것을 제외하고는 상술한 실시예 2-1과 동일한 방법으로, 도 2에 나타낸 모식도의 순서대로, SNP 마커를 발굴하였다. 그 결과 최종적으로 482개의 SNP마커를 발굴하였다. 상술한 실시예 2-1에서 발굴한 918개의 SNP와 본 실시예 2-2에서 발굴한 482개의 SNP는 서로 상이하다.
보다 상세하게는, 도 2에 나타낸 바와 같이, HWE에서 유전자좌 선택 결과 1,856,032개의 SNP, 유전자 영역 내 또는 근처 SNP 제외 결과 72,701개의 SNP, 코베리옴의 이형접합자를 사용한 SNP 유전자좌 제외 결과 11,662개의 SNP, 연관 비평형에서 SNP 유전자좌 제외 결과 1,227개의 SNP, 및 반복 영역에서 SNP 유전자좌 제외 결과 최종 482개의 SNP 패널을 발굴하였다.
한국인 친족 관계 확인을 위해 선별된 482개의 SNP는 아래 표 2에 나타내었으며, 101번째 염기에 각 SNP를 포함하는 201개의 뉴클레오타이드로 이루어진 서열을 서열번호 919 내지 서열번호 1400에 각각 나타내었다. SNP의 염색체상 위치는 인간 참조 유전체 GRCh38(hg38)을 기준으로 나타내었고, 각 SNP는 101번째 염기[n]에 참조 대립유전자(reference allele; ref. allele) 또는 선택적 대립유전자(alternative allele; alt. allele)가 위치할 수 있다. 또한, NCBI에서 제공하는 오픈 데이터베이스인 dbSNP의 참조 SNP 클러스터 ID 숫자인 rs 번호(rs#)도 함께 기재하였다.
| 서열번호 | 염색체 번호 | 위치 (position) (GRCh38) |
Ref. Allele |
Alt. Allele B |
dbSNP rs# |
서열번호 | 염색체 번호 | 위치 (position) (GRCh38) |
Ref. Allele |
Alt. Allele B |
dbSNP rs# |
| 919 | 1 | 29604465 | C | T | rs10914306 | 1160 | 3 | 87428480 | C | T | rs6551480 |
| 920 | 1 | 30527344 | G | A | rs385109 | 1161 | 3 | 88701707 | T | C | rs6551361 |
| 921 | 1 | 30587633 | A | C | rs472061 | 1162 | 3 | 88734991 | G | A | rs1384774 |
| 922 | 1 | 34488255 | T | G | rs4653045 | 1163 | 3 | 89728859 | T | C | rs13062221 |
| 923 | 1 | 34522675 | A | T | rs7556065 | 1164 | 3 | 90368610 | T | C | rs9799286 |
| 924 | 1 | 79684353 | A | T | rs1479739 | 1165 | 3 | 94247621 | G | A | rs1584929 |
| 925 | 1 | 79770134 | T | C | rs12022561 | 1166 | 3 | 94404708 | T | C | rs6810199 |
| 926 | 1 | 80793258 | C | T | rs2147084 | 1167 | 3 | 95327126 | C | T | rs1607490 |
| 927 | 1 | 98389610 | G | A | rs728656 | 1168 | 3 | 104192865 | G | C | rs7610885 |
| 928 | 1 | 98527441 | G | A | rs1081415 | 1169 | 3 | 104308959 | T | C | rs55714502 |
| 929 | 1 | 101495586 | T | G | rs4907942 | 1170 | 3 | 104338639 | A | G | rs7620614 |
| 930 | 1 | 101509262 | T | C | rs187823 | 1171 | 3 | 104863022 | G | A | rs13061652 |
| 931 | 1 | 102097084 | C | A | rs6684718 | 1172 | 3 | 104885661 | A | T | rs12632614 |
| 932 | 1 | 102489787 | A | G | rs1934710 | 1173 | 3 | 105174140 | A | G | rs16850936 |
| 933 | 1 | 104435454 | C | T | rs994637 | 1174 | 3 | 110255073 | T | C | rs10934026 |
| 934 | 1 | 104460389 | A | C | rs7417401 | 1175 | 3 | 135551769 | T | C | rs9289494 |
| 935 | 1 | 105132509 | C | A | rs6700492 | 1176 | 3 | 135742813 | G | A | rs9851816 |
| 936 | 1 | 105135344 | T | C | rs4399210 | 1177 | 3 | 144663747 | A | C | rs1178938 |
| 937 | 1 | 105175009 | A | G | rs4847034 | 1178 | 3 | 144730082 | C | T | rs6440266 |
| 938 | 1 | 106256205 | G | C | rs10881377 | 1179 | 3 | 145181942 | G | C | rs7633246 |
| 939 | 1 | 106648863 | A | G | rs10785799 | 1180 | 3 | 145237602 | A | G | rs6778538 |
| 940 | 1 | 118369123 | T | C | rs7541204 | 1181 | 3 | 145269689 | C | T | rs1596717 |
| 941 | 1 | 118450338 | G | A | rs2798449 | 1182 | 3 | 152954990 | G | T | rs6785504 |
| 942 | 1 | 163617565 | G | T | rs10917813 | 1183 | 3 | 161929653 | A | C | rs11711859 |
| 943 | 1 | 164034133 | G | A | rs2346420 | 1184 | 3 | 162149732 | A | T | rs1397231 |
| 944 | 1 | 187817530 | G | T | rs2430184 | 1185 | 3 | 162803551 | G | A | rs13098441 |
| 945 | 1 | 187853414 | G | C | rs2430147 | 1186 | 3 | 163845479 | A | C | rs1492782 |
| 946 | 1 | 191496601 | G | C | rs1338033 | 1187 | 3 | 189501341 | G | A | rs2014894 |
| 947 | 1 | 191560373 | T | A | rs1113634 | 1188 | 3 | 189508343 | C | A | rs16864459 |
| 948 | 1 | 195163463 | C | T | rs598224 | 1189 | 3 | 191019468 | G | A | rs9864904 |
| 949 | 1 | 195871676 | A | G | rs4256795 | 1190 | 3 | 191757874 | A | G | rs709110 |
| 950 | 1 | 208472915 | T | C | rs12024584 | 1191 | 3 | 191771515 | T | A | rs1066624 |
| 951 | 1 | 208868883 | G | A | rs6692199 | 1192 | 3 | 191772184 | T | C | rs1083670 |
| 952 | 1 | 214768252 | G | A | rs12022703 | 1193 | 3 | 194947038 | C | T | rs2082377 |
| 953 | 1 | 217238392 | G | A | rs7542498 | 1194 | 4 | 10855090 | G | A | rs9991940 |
| 954 | 1 | 218654513 | T | C | rs1481345 | 1195 | 4 | 10915291 | T | C | rs12511310 |
| 955 | 1 | 218688412 | T | A | rs1383759 | 1196 | 4 | 11051913 | A | G | rs6846243 |
| 956 | 1 | 218765222 | C | T | rs9431104 | 1197 | 4 | 12020898 | T | G | rs6448854 |
| 957 | 1 | 221010746 | T | C | rs1360887 | 1198 | 4 | 18123104 | T | C | rs6854314 |
| 958 | 1 | 238648216 | G | A | rs12729311 | 1199 | 4 | 24281377 | A | G | rs6448255 |
| 959 | 10 | 9564609 | C | T | rs1324884 | 1200 | 4 | 24294211 | G | A | rs4697450 |
| 960 | 10 | 9595693 | T | A | rs11256268 | 1201 | 4 | 24380505 | G | C | rs2007816 |
| 961 | 10 | 20655689 | G | T | rs11012237 | 1202 | 4 | 27718168 | A | G | rs1992981 |
| 962 | 10 | 29068578 | A | G | rs12767581 | 1203 | 4 | 30201580 | C | T | rs2613184 |
| 963 | 10 | 29085839 | C | T | rs517770 | 1204 | 4 | 30477251 | G | A | rs4692459 |
| 964 | 10 | 29103651 | C | T | rs540804 | 1205 | 4 | 30567961 | G | A | rs10014617 |
| 965 | 10 | 57615107 | C | T | rs4463781 | 1206 | 4 | 31742430 | G | A | rs1157893 |
| 966 | 10 | 61227405 | G | A | rs10821875 | 1207 | 4 | 31783076 | T | G | rs988466 |
| 967 | 10 | 81366347 | C | T | rs561182 | 1208 | 4 | 32850196 | A | G | rs7438388 |
| 968 | 10 | 81574714 | A | G | rs11190474 | 1209 | 4 | 34866074 | G | A | rs7670648 |
| 969 | 10 | 83556706 | T | A | rs7081137 | 1210 | 4 | 35194064 | C | G | rs2170284 |
| 970 | 10 | 84834585 | G | A | rs2991926 | 1211 | 4 | 35256888 | T | C | rs4541530 |
| 971 | 10 | 109054770 | T | C | rs723483 | 1212 | 4 | 35347626 | G | C | rs13112950 |
| 972 | 10 | 125292604 | A | G | rs3851566 | 1213 | 4 | 35713140 | C | T | rs13126959 |
| 973 | 10 | 128431579 | T | G | rs12782052 | 1214 | 4 | 36755075 | T | C | rs12650943 |
| 974 | 10 | 128549205 | A | G | rs12413518 | 1215 | 4 | 45636830 | T | C | rs2061231 |
| 975 | 10 | 128800718 | G | A | rs12783941 | 1216 | 4 | 45792876 | C | T | rs1389037 |
| 976 | 11 | 26825763 | C | T | rs1375971 | 1217 | 4 | 59362799 | G | A | rs1119950 |
| 977 | 11 | 36877200 | C | T | rs7120395 | 1218 | 4 | 60139678 | G | T | rs1345046 |
| 978 | 11 | 36977052 | A | G | rs11033894 | 1219 | 4 | 60499876 | G | A | rs10780045 |
| 979 | 11 | 39379076 | A | G | rs994587 | 1220 | 4 | 60509271 | C | T | rs2340729 |
| 980 | 11 | 39677236 | T | C | rs11035405 | 1221 | 4 | 63631834 | G | C | rs1456847 |
| 981 | 11 | 42834470 | C | T | rs7118693 | 1222 | 4 | 63670114 | G | A | rs13103808 |
| 982 | 11 | 42835318 | C | T | rs6485361 | 1223 | 4 | 64064605 | A | G | rs1449188 |
| 983 | 11 | 48744042 | A | C | rs10769445 | 1224 | 4 | 66735444 | G | A | rs11937537 |
| 984 | 11 | 91521201 | G | A | rs4753336 | 1225 | 4 | 67048906 | C | A | rs1425663 |
| 985 | 11 | 98834858 | C | T | rs7925701 | 1226 | 4 | 91768524 | G | C | rs7435103 |
| 986 | 11 | 100459226 | C | T | rs11224242 | 1227 | 4 | 95982514 | T | C | rs973852 |
| 987 | 11 | 113586326 | T | C | rs10750026 | 1228 | 4 | 114389243 | G | C | rs6838486 |
| 988 | 11 | 114823551 | C | T | rs12279327 | 1229 | 4 | 124944164 | A | C | rs1021631 |
| 989 | 11 | 114990330 | G | A | rs7944043 | 1230 | 4 | 129489522 | A | C | rs643541 |
| 990 | 11 | 116057018 | T | A | rs11826183 | 1231 | 4 | 130103316 | T | C | rs1873868 |
| 991 | 11 | 116126245 | C | T | rs489357 | 1232 | 4 | 130198459 | G | T | rs10001806 |
| 992 | 11 | 116134453 | T | C | rs576425 | 1233 | 4 | 133431748 | A | G | rs1032439 |
| 993 | 11 | 127508316 | G | T | rs10790898 | 1234 | 4 | 133676682 | C | T | rs2713266 |
| 994 | 11 | 127522266 | G | C | rs17187 | 1235 | 4 | 136672250 | T | C | rs12512934 |
| 995 | 11 | 127787176 | A | G | rs10790919 | 1236 | 4 | 141842417 | G | A | rs2099884 |
| 996 | 12 | 29886091 | G | A | rs12302114 | 1237 | 4 | 155047285 | C | T | rs17032387 |
| 997 | 12 | 37727134 | A | G | rs1663281 | 1238 | 4 | 156146376 | T | C | rs6419277 |
| 998 | 12 | 69101047 | T | G | rs7397436 | 1239 | 4 | 156199668 | T | C | rs6536157 |
| 999 | 12 | 72873355 | C | T | rs7962306 | 1240 | 4 | 156208487 | A | G | rs10029573 |
| 1000 | 12 | 74909600 | A | C | rs6582255 | 1241 | 4 | 159982164 | C | T | rs4627809 |
| 1001 | 12 | 82112924 | C | G | rs12829083 | 1242 | 4 | 160103006 | G | A | rs1612279 |
| 1002 | 12 | 82115234 | G | A | rs7968088 | 1243 | 4 | 160138722 | T | C | rs13128591 |
| 1003 | 12 | 84558692 | T | A | rs10779106 | 1244 | 4 | 160385012 | A | G | rs6835941 |
| 1004 | 12 | 87493362 | G | A | rs1603406 | 1245 | 4 | 178968553 | A | T | rs1982408 |
| 1005 | 13 | 23033352 | C | A | rs9552805 | 1246 | 4 | 179566153 | T | G | rs2610997 |
| 1006 | 13 | 31588766 | A | G | rs202451 | 1247 | 4 | 179661345 | C | T | rs12509486 |
| 1007 | 13 | 34807654 | T | G | rs13378363 | 1248 | 4 | 179714973 | C | T | rs4425420 |
| 1008 | 13 | 37370702 | G | A | rs9594199 | 1249 | 4 | 179738934 | C | T | rs2383397 |
| 1009 | 13 | 47110259 | G | C | rs9567787 | 1250 | 4 | 180861421 | T | C | rs12648100 |
| 1010 | 13 | 55866632 | T | C | rs2645931 | 1251 | 4 | 180874878 | G | A | rs2140198 |
| 1011 | 13 | 56726154 | A | G | rs812612 | 1252 | 4 | 181383720 | G | T | rs4522908 |
| 1012 | 13 | 56990794 | T | C | rs7995965 | 1253 | 5 | 2364512 | T | C | rs316598 |
| 1013 | 13 | 56991225 | A | G | rs7995278 | 1254 | 5 | 2453263 | A | G | rs1908159 |
| 1014 | 13 | 64671768 | G | T | rs359365 | 1255 | 5 | 3702962 | A | C | rs1039460 |
| 1015 | 13 | 64768896 | C | T | rs9540214 | 1256 | 5 | 3717886 | T | G | rs1502635 |
| 1016 | 13 | 69512112 | T | C | rs9572181 | 1257 | 5 | 18396275 | A | C | rs4866100 |
| 1017 | 13 | 70307833 | T | C | rs9592695 | 1258 | 5 | 19344111 | A | G | rs16886123 |
| 1018 | 13 | 72216211 | A | G | rs488071 | 1259 | 5 | 23115159 | A | C | rs2937021 |
| 1019 | 13 | 84680934 | T | C | rs4284530 | 1260 | 5 | 23155563 | T | G | rs7736091 |
| 1020 | 13 | 86567392 | T | C | rs8000086 | 1261 | 5 | 26114387 | A | G | rs7721783 |
| 1021 | 13 | 103176202 | G | A | rs7990727 | 1262 | 5 | 26195022 | C | T | rs4701263 |
| 1022 | 13 | 103176464 | C | T | rs1750410 | 1263 | 5 | 26250139 | G | A | rs6892024 |
| 1023 | 13 | 103176493 | G | A | rs1730643 | 1264 | 5 | 26263490 | A | T | rs4521437 |
| 1024 | 13 | 103226212 | A | G | rs6491731 | 1265 | 5 | 27705900 | A | G | rs11748760 |
| 1025 | 13 | 103545411 | A | G | rs2390905 | 1266 | 5 | 27766133 | C | T | rs12659895 |
| 1026 | 13 | 103617386 | T | C | rs996758 | 1267 | 5 | 30946767 | T | G | rs1276178 |
| 1027 | 13 | 103720841 | T | C | rs2065391 | 1268 | 5 | 34486721 | G | A | rs10051815 |
| 1028 | 13 | 104362873 | G | A | rs1590919 | 1269 | 5 | 46128373 | C | T | rs11486611 |
| 1029 | 13 | 104522717 | A | C | rs9300939 | 1270 | 5 | 46359219 | C | T | rs4975929 |
| 1030 | 13 | 105067040 | T | C | rs9519577 | 1271 | 5 | 46385222 | T | A | rs12515999 |
| 1031 | 13 | 105235992 | G | A | rs3015358 | 1272 | 5 | 50161448 | T | C | rs8188203 |
| 1032 | 14 | 43833881 | G | C | rs941943 | 1273 | 5 | 50192402 | G | A | rs7293378 |
| 1033 | 14 | 62322229 | G | T | rs8012287 | 1274 | 5 | 50246086 | G | A | rs11738711 |
| 1034 | 14 | 82897096 | A | G | rs6574729 | 1275 | 5 | 52409393 | G | A | rs10060810 |
| 1035 | 14 | 83205008 | G | A | rs8013139 | 1276 | 5 | 63411710 | G | A | rs4235499 |
| 1036 | 14 | 83376648 | T | G | rs229807 | 1277 | 5 | 63688050 | G | T | rs13157106 |
| 1037 | 14 | 84313150 | C | T | rs10148642 | 1278 | 5 | 63747610 | T | C | rs260995 |
| 1038 | 14 | 86616242 | C | T | rs6574903 | 1279 | 5 | 63779327 | C | T | rs1472695 |
| 1039 | 15 | 37678161 | G | A | rs8038727 | 1280 | 5 | 63784827 | T | G | rs7706163 |
| 1040 | 15 | 53255483 | G | A | rs4776123 | 1281 | 5 | 71859118 | A | G | rs6878538 |
| 1041 | 15 | 96954277 | T | G | rs6496198 | 1282 | 5 | 84623964 | T | C | rs11960020 |
| 1042 | 15 | 96977000 | T | C | rs12900387 | 1283 | 5 | 84708783 | C | T | rs10462415 |
| 1043 | 16 | 17642369 | T | C | rs9923864 | 1284 | 5 | 84861350 | G | A | rs13165966 |
| 1044 | 16 | 26929850 | G | A | rs11074808 | 1285 | 5 | 84865035 | T | C | rs1500619 |
| 1045 | 16 | 26938513 | T | C | rs4787393 | 1286 | 5 | 99256157 | T | C | rs1116078 |
| 1046 | 16 | 26949195 | C | G | rs9929685 | 1287 | 5 | 103665396 | T | C | rs11952040 |
| 1047 | 16 | 48961634 | G | C | rs12598934 | 1288 | 5 | 110023280 | T | C | rs2925117 |
| 1048 | 16 | 51903322 | T | C | rs2386959 | 1289 | 5 | 119791509 | A | C | rs12521697 |
| 1049 | 16 | 59318853 | T | A | rs2081227 | 1290 | 5 | 119809068 | C | T | rs6595196 |
| 1050 | 16 | 60193214 | G | T | rs12598588 | 1291 | 5 | 120900842 | T | C | rs6888945 |
| 1051 | 16 | 61421425 | G | C | rs4784117 | 1292 | 5 | 123788539 | C | A | rs29614 |
| 1052 | 16 | 79387940 | G | T | rs12444602 | 1293 | 5 | 123801176 | C | A | rs257142 |
| 1053 | 16 | 79927433 | A | G | rs4889046 | 1294 | 5 | 123872869 | T | C | rs330683 |
| 1054 | 16 | 82321149 | G | A | rs2967364 | 1295 | 5 | 123905854 | C | T | rs12189340 |
| 1055 | 17 | 10982759 | C | G | rs4522450 | 1296 | 5 | 144035178 | C | T | rs316056 |
| 1056 | 17 | 11025731 | C | T | rs7211507 | 1297 | 5 | 144660842 | T | G | rs10075043 |
| 1057 | 17 | 14523242 | C | G | rs11078254 | 1298 | 5 | 153366050 | T | A | rs300340 |
| 1058 | 17 | 52262307 | G | C | rs1486751 | 1299 | 5 | 169401286 | A | C | rs6555860 |
| 1059 | 17 | 52270460 | C | G | rs7220900 | 1300 | 5 | 169414353 | G | A | rs12522101 |
| 1060 | 17 | 65347054 | T | C | rs6504295 | 1301 | 5 | 171558836 | T | C | rs7720865 |
| 1061 | 17 | 70885429 | T | C | rs2367119 | 1302 | 5 | 175157145 | C | T | rs12189524 |
| 1062 | 18 | 4571090 | C | A | rs7230421 | 1303 | 5 | 175184337 | T | C | rs4336372 |
| 1063 | 18 | 28348700 | C | T | rs7237664 | 1304 | 6 | 9411740 | A | C | rs2327167 |
| 1064 | 18 | 30562573 | T | C | rs2617892 | 1305 | 6 | 9492485 | A | C | rs12200413 |
| 1065 | 18 | 38440132 | C | T | rs7241992 | 1306 | 6 | 9495536 | C | T | rs6905187 |
| 1066 | 18 | 38461161 | T | C | rs7232769 | 1307 | 6 | 15789879 | G | T | rs220923 |
| 1067 | 18 | 38482597 | G | A | rs9947632 | 1308 | 6 | 15819154 | C | T | rs382182 |
| 1068 | 18 | 38525993 | C | T | rs12965155 | 1309 | 6 | 15820194 | C | T | rs522264 |
| 1069 | 18 | 41139108 | C | T | rs17696192 | 1310 | 6 | 61473996 | C | T | rs9360231 |
| 1070 | 18 | 43634254 | C | T | rs12455868 | 1311 | 6 | 62712100 | A | G | rs2843106 |
| 1071 | 18 | 56461832 | C | T | rs374277 | 1312 | 6 | 62858698 | A | G | rs12524104 |
| 1072 | 18 | 61158634 | T | G | rs242717 | 1313 | 6 | 62955241 | G | A | rs4710390 |
| 1073 | 18 | 66722766 | A | G | rs11659281 | 1314 | 6 | 66333590 | A | G | rs12530173 |
| 1074 | 18 | 72232917 | G | A | rs8084367 | 1315 | 6 | 66554684 | T | C | rs7752244 |
| 1075 | 18 | 72383000 | A | G | rs7505475 | 1316 | 6 | 66857061 | C | A | rs4593347 |
| 1076 | 18 | 73006310 | A | C | rs11151820 | 1317 | 6 | 66995841 | A | G | rs9453960 |
| 1077 | 18 | 73024567 | C | T | rs1114342 | 1318 | 6 | 76229150 | T | C | rs994107 |
| 1078 | 19 | 24338821 | G | A | rs3976345 | 1319 | 6 | 77204307 | G | A | rs12206214 |
| 1079 | 2 | 4375557 | C | G | rs12052610 | 1320 | 6 | 78038636 | G | A | rs9343715 |
| 1080 | 2 | 5054916 | A | G | rs6714934 | 1321 | 6 | 78342170 | T | C | rs818268 |
| 1081 | 2 | 5135113 | T | C | rs1453760 | 1322 | 6 | 90853774 | A | C | rs994916 |
| 1082 | 2 | 5205599 | A | G | rs4462764 | 1323 | 6 | 90952546 | C | T | rs12664234 |
| 1083 | 2 | 5431227 | A | G | rs13412303 | 1324 | 6 | 94642318 | C | T | rs2493950 |
| 1084 | 2 | 35575230 | C | T | rs11678496 | 1325 | 6 | 94748599 | G | A | rs794672 |
| 1085 | 2 | 35897209 | C | T | rs1524144 | 1326 | 6 | 94876989 | C | T | rs197899 |
| 1086 | 2 | 35897322 | G | T | rs1524145 | 1327 | 6 | 95779949 | C | T | rs4840033 |
| 1087 | 2 | 35909964 | C | T | rs12712470 | 1328 | 6 | 103139928 | C | T | rs9373682 |
| 1088 | 2 | 36152577 | G | A | rs1167454 | 1329 | 6 | 112725403 | C | T | rs9384841 |
| 1089 | 2 | 40879880 | G | A | rs982428 | 1330 | 6 | 114645435 | G | A | rs9481463 |
| 1090 | 2 | 49709726 | A | G | rs1914778 | 1331 | 6 | 115107468 | G | A | rs9488534 |
| 1091 | 2 | 53281551 | T | G | rs11678259 | 1332 | 6 | 115816330 | T | A | rs4113207 |
| 1092 | 2 | 56532828 | G | C | rs1304898 | 1333 | 6 | 117161819 | G | A | rs9400981 |
| 1093 | 2 | 57645567 | C | T | rs2612313 | 1334 | 6 | 137357692 | C | T | rs9373188 |
| 1094 | 2 | 75355062 | T | C | rs4853141 | 1335 | 6 | 137380770 | T | G | rs6913805 |
| 1095 | 2 | 78710839 | G | A | rs1993146 | 1336 | 6 | 145001237 | A | G | rs946317 |
| 1096 | 2 | 81057349 | C | A | rs7597163 | 1337 | 6 | 145040854 | A | C | rs1104835 |
| 1097 | 2 | 81807528 | C | G | rs4852629 | 1338 | 6 | 145045960 | C | A | rs9376894 |
| 1098 | 2 | 83395037 | C | T | rs2043015 | 1339 | 6 | 145081204 | A | G | rs495269 |
| 1099 | 2 | 83761345 | T | G | rs1115900 | 1340 | 6 | 145196271 | C | A | rs4896780 |
| 1100 | 2 | 117299195 | T | C | rs1377407 | 1341 | 6 | 153542928 | G | T | rs1674729 |
| 1101 | 2 | 118347401 | G | A | rs4276037 | 1342 | 6 | 153547060 | A | C | rs567878 |
| 1102 | 2 | 123584690 | G | A | rs6709442 | 1343 | 6 | 155760373 | C | T | rs11156041 |
| 1103 | 2 | 125967099 | T | G | rs6719448 | 1344 | 6 | 164563082 | C | G | rs2019943 |
| 1104 | 2 | 129702523 | T | G | rs4662980 | 1345 | 7 | 4371578 | G | A | rs10488360 |
| 1105 | 2 | 133703450 | A | G | rs4305321 | 1346 | 7 | 4393607 | A | G | rs6959971 |
| 1106 | 2 | 133753999 | G | A | rs1900351 | 1347 | 7 | 9293438 | C | G | rs4720832 |
| 1107 | 2 | 133771383 | T | C | rs746838 | 1348 | 7 | 9294891 | T | A | rs4472411 |
| 1108 | 2 | 133826291 | G | C | rs4954082 | 1349 | 7 | 9369330 | A | G | rs7780856 |
| 1109 | 2 | 133868385 | T | C | rs10173030 | 1350 | 7 | 24017376 | A | C | rs10233834 |
| 1110 | 2 | 133893655 | G | A | rs12464286 | 1351 | 7 | 24028724 | T | C | rs11764999 |
| 1111 | 2 | 133896773 | T | G | rs1838883 | 1352 | 7 | 24030332 | A | G | rs719158 |
| 1112 | 2 | 137827035 | C | T | rs733196 | 1353 | 7 | 41266574 | G | A | rs6943312 |
| 1113 | 2 | 142309589 | A | G | rs6429959 | 1354 | 7 | 41373358 | G | T | rs10251186 |
| 1114 | 2 | 146295728 | G | T | rs2381913 | 1355 | 7 | 41472141 | A | G | rs273148 |
| 1115 | 2 | 146707627 | G | A | rs10184858 | 1356 | 7 | 52603462 | A | G | rs10241795 |
| 1116 | 2 | 150761094 | G | A | rs11893757 | 1357 | 7 | 62559778 | A | G | rs2123573 |
| 1117 | 2 | 153030496 | T | C | rs12618138 | 1358 | 7 | 67485831 | G | A | rs6953207 |
| 1118 | 2 | 160616670 | G | C | rs13024212 | 1359 | 7 | 67908536 | T | A | rs4236217 |
| 1119 | 2 | 180292263 | C | T | rs3845718 | 1360 | 7 | 89645203 | T | C | rs2888705 |
| 1120 | 2 | 191570538 | G | A | rs4640333 | 1361 | 7 | 109106133 | T | C | rs2691991 |
| 1121 | 2 | 192471682 | T | C | rs1601323 | 1362 | 7 | 118715021 | G | A | rs6967747 |
| 1122 | 2 | 192941098 | T | C | rs765278 | 1363 | 7 | 125751591 | A | G | rs1419607 |
| 1123 | 2 | 193464423 | T | C | rs764142 | 1364 | 7 | 126201859 | C | G | rs562415 |
| 1124 | 2 | 195136595 | A | G | rs938065 | 1365 | 7 | 145451172 | C | T | rs850362 |
| 1125 | 2 | 220959282 | T | C | rs13021771 | 1366 | 7 | 145929887 | G | A | rs4314573 |
| 1126 | 2 | 220987575 | A | G | rs2034747 | 1367 | 7 | 153596114 | G | A | rs4266558 |
| 1127 | 2 | 221759957 | A | G | rs1364386 | 1368 | 8 | 59287402 | G | C | rs4737540 |
| 1128 | 2 | 225864180 | C | T | rs13013295 | 1369 | 8 | 75675676 | T | G | rs724436 |
| 1129 | 2 | 226293522 | A | G | rs1515113 | 1370 | 8 | 92250654 | A | G | rs1444506 |
| 1130 | 2 | 226466009 | A | T | rs6724846 | 1371 | 8 | 97459973 | C | T | rs499177 |
| 1131 | 2 | 235295103 | T | G | rs11901273 | 1372 | 8 | 114054058 | C | G | rs10087835 |
| 1132 | 20 | 6891490 | C | G | rs6054584 | 1373 | 8 | 115087403 | T | A | rs309618 |
| 1133 | 20 | 12711853 | A | G | rs6033500 | 1374 | 8 | 115158348 | G | A | rs7836816 |
| 1134 | 20 | 40229271 | G | C | rs6028968 | 1375 | 8 | 115242924 | A | G | rs11996430 |
| 1135 | 20 | 40515646 | T | A | rs6129620 | 1376 | 8 | 116507424 | C | T | rs4128874 |
| 1136 | 20 | 41854780 | T | C | rs2211350 | 1377 | 8 | 121489749 | T | C | rs4870766 |
| 1137 | 20 | 41886176 | T | C | rs7265011 | 1378 | 8 | 137210744 | C | T | rs4481636 |
| 1138 | 20 | 54373070 | C | T | rs6023167 | 1379 | 8 | 137216529 | T | C | rs4546699 |
| 1139 | 20 | 54963579 | A | G | rs2870375 | 1380 | 9 | 8172467 | A | G | rs7861009 |
| 1140 | 20 | 60916617 | A | C | rs2426956 | 1381 | 9 | 8176622 | T | C | rs10733543 |
| 1141 | 21 | 20045854 | A | G | rs8126652 | 1382 | 9 | 12439164 | C | G | rs1576657 |
| 1142 | 21 | 23594494 | T | C | rs12626525 | 1383 | 9 | 24722712 | G | C | rs1888992 |
| 1143 | 21 | 26731325 | A | G | rs2187226 | 1384 | 9 | 25222108 | G | C | rs10966800 |
| 1144 | 3 | 5358553 | G | C | rs4685910 | 1385 | 9 | 25275215 | A | G | rs10812209 |
| 1145 | 3 | 5378490 | A | G | rs7649517 | 1386 | 9 | 26414782 | T | C | rs1855980 |
| 1146 | 3 | 5457906 | C | G | rs7649155 | 1387 | 9 | 27720612 | A | T | rs997638 |
| 1147 | 3 | 5465019 | A | G | rs6775400 | 1388 | 9 | 28988968 | T | C | rs10968861 |
| 1148 | 3 | 5534813 | A | G | rs6774182 | 1389 | 9 | 29466037 | G | A | rs2147432 |
| 1149 | 3 | 5686597 | A | C | rs4685973 | 1390 | 9 | 30078751 | C | G | rs2002954 |
| 1150 | 3 | 5710199 | G | A | rs6799738 | 1391 | 9 | 31847260 | T | C | rs10970554 |
| 1151 | 3 | 5782842 | A | G | rs1435352 | 1392 | 9 | 74000474 | A | T | rs2933020 |
| 1152 | 3 | 16071585 | C | A | rs11711890 | 1393 | 9 | 78848212 | A | G | rs10780262 |
| 1153 | 3 | 26501472 | A | C | rs7637842 | 1394 | 9 | 80987559 | G | T | rs10780480 |
| 1154 | 3 | 26862402 | C | T | rs11711747 | 1395 | 9 | 101894652 | T | C | rs823923 |
| 1155 | 3 | 30169615 | T | C | rs2371997 | 1396 | 9 | 118932967 | G | T | rs4631540 |
| 1156 | 3 | 31025960 | C | T | rs294314 | 1397 | 9 | 119675443 | G | C | rs1860670 |
| 1157 | 3 | 35043475 | T | C | rs713144 | 1398 | 9 | 119771210 | G | T | rs2781115 |
| 1158 | 3 | 67111680 | C | T | rs7632236 | 1399 | 9 | 120113376 | T | A | rs1335219 |
| 1159 | 3 | 84204191 | G | A | rs6780104 | 1400 | 9 | 124147208 | T | A | rs10986245 |
상술한 실시예 2에서 서로 관련이 없는 88명의 한국인으로부터 발굴한 918개의 SNP 패널 및 482개의 SNP 패널을 이용하여, 이하의 실시예에서 한국 촌수 기준으로 1촌 내지 4촌 관계에 있는 한국인 집단에서 친족관계를 분석하였다.
후술될 실시예 3에서는 1촌 내지 4촌 관계에 있는 한국인 집단에서 수득한 시료에서 유전체를 추출하고 정제하여 양질의 DNA를 수득하였고, 실시예 4에서는 양질의 DNA로부터 염기서열분석을 위한 NGS 라이브러리를 제작한 후, 실시예 5에서는 수득한 NGS 라이브러리를 이용하여 염기서열분석을 수행하였다. 실시예 6에서 염기서열분석으로 생산된 데이터로부터 유전체 정렬 결과 파일을 추출하였고, 실시예 7에서는 실시예 2에서 수득한 SNP 마커 정보를 기반으로 하여 실시예 6에서 수득한 유전체 정렬 결과 파일로부터 IBS(identity by state) 테스트 분석을 수행하고 혈연관계 계수를 도출함으로써 친족관계를 확인하는 분석을 수행하였다.
실시예 3. 샘플링, DNA의 추출, 정제 및 품질 관리 방법
유전체 분석은 i) 구강 시료에서 추출한 gDNA(genomic DNA)를 PCR(polymerase chain reaction)로 증폭하는 과정, 및 ii) 증폭한 DNA를 NGS(next generation sequencing) 분석을 통하여 유전체를 해독(염기서열분석)하는 과정으로 나누어 수행하였다. 추출된 gDNA는 DNA QC(quality control, 품질 관리) 과정을 거친 후, NGS 라이브러리(library)를 구축하였으며, NGS 서열을 충분히 확보하는 것을 목표로 하였다.
3-1: 구강 시료 수집
본 발명에서는 대형 재난이나 오랜 시간이 지나 대조 가능한 직계가 사망하여 현재 기법으로는 감정이 불가하거나(즉, 부모의 DNA 정보가 없는 경우), 유가족의 유전적 거리가 먼 경우에도 친족 관계 예측이 가능한 SNP 마커를 도출하기 위하여, IRB(Institutional Review Board) 승인하, 한국 촌수를 기준으로 1촌 내지 4촌의 친족관계에 있는 한국인 90명의 구강 시료(타액 또는 스왑)를 채취하였다.
한국인 90개체(individual) 중 40개체는 서로 형제, 자매 및 남매로 구성된 한국 촌수 기준 2촌 관계인 가족 당 2명씩 20 가족인 총 40개체이고, 상기 40개체 중에서 8개체는 4개체씩 모계유전형인 Second degree relative 관계로, 상세하게는 서로 모-자-녀-이모 관계 또는 모-자매-이모 관계이다. 상술한 한국인 90개체 중 50개체는 서로 한국 촌수 기준 1촌 내지 4촌 관계이다.
3-2: gDNA 추출
상술한 실시예 3-1에서 수득한 시료로부터 DNeasy® Blood & Tissue Kit (Qiagen사, 미국)를 사용하여 제조사의 지시사항에 따라 다음과 같이 gDNA를 추출하였으나, 시료로부터 DNA를 추출하는 방법이 반드시 이에 제한되는 것은 아니며, gDNA를 추출하는 당업계에 공지된 방법이라면 제한없이 사용될 수 있음을 당업자라면 이해할 것이다.
구체적으로, 타액 1 ml에 PBS (phosphate buffered saline) 4 ml을 첨가한 후, 1,800 x g에서 5분 동안 원심분리(centrifugation)하였다. 원심분리 후 상층액(supernatant)을 제거하고, 펠렛(pellet)에 180 μl의 PBS를 첨가한 다음 펠렛을 풀어주고, 20 μl의 프로테아제 K (protease K) 및 200 μl의 버퍼 AL (lysis buffer)를 첨가한 후, 볼텍스(vortex)로 충분히 혼합하였다. 그 다음, 56℃에서 10분 동안 인큐베이션(incubation)하고, 200 μl의 에탄올(96% v/v 내지 100% v/v 농도)을 첨가한 후 충분히 혼합하였다.
DNA를 컬럼에 결합시킴으로써 혼합물로부터 DNA를 분리하기 위해, 혼합물을 키트(kit)에서 제공하는 컬럼(DNeasy Mini spin column)에 첨가한 다음, 6,000 x g에서 1분 동안 원심분리하고, 컬럼을 통과한 액체(flow-through)를 제거하였다.
세척을 위해, 컬럼에 500 μl의 버퍼 AW1 (wash buffer)를 첨가한 후 6,000 x g에서 1분 동안 원심분리한 후, 컬럼을 통과한 액체를 제거하였다. 또한, 컬럼에 500 μl의 버퍼 AW2 (wash buffer)를 첨가한 후 20,000 x g에서 3분 동안 원심분리한 후, 컬럼을 통과한 액체를 제거하였다.
컬럼으로부터 DNA를 용리(elution)하기 위해, 컬럼을 새로운 1.5 ml 튜브에 넣은 후, 200 μl의 버퍼 AE (elution buffer)를 컬럼에 직접 첨가하고, 상온에서 1분 동안 인큐베이션하였다. 그 다음, 6,000 x g에서 1분 동안 원심분리함으로써, gDNA를 수득하였다.
3-3: DNA 정제
고품질의 DNA 확보를 위해, AMPure XP bead(Beckman Coulter사)를 이용하여 제조사의 지시사항에 따라 다음과 같이 DNA 클린업(Cleanup)을 진행하였으나, DNA를 정제하는 방법이 반드시 이에 제한되는 것은 아니며, 당업계에 공지된 DNA를 정제하는 방법이라면 제한없이 사용될 수 있음을 당업자라면 이해할 것이다.
실험 최소 30분 전에 자성 비드(bead)를 상온에서 인큐베이션한 후 충분히 섞고 사용하였다. 상기 실시예 3-2에서 수득한 gDNA 부피에 대해 1.8배 부피의 비드를 gDNA에 첨가하고 파이펫팅(pipetting)으로 충분히 혼합하였다. 그 다음, 상온에서 5분 동안 인큐베이션하여, DNA와 비드가 결합하게 하였다.
약하게 원심분리 후, 샘플 튜브(tube)를 자성 분리 랙(magnetic separation rack)에 장착하고 2분 내지 5분 동안 두어 자성 비드 및 DNA 복합체를 혼합물로부터 분리시켰다. 상층액이 투명해지면 상층액을 제거하였다.
세척을 위해, 자성 분리 랙에 샘플 튜브를 장착한 채로 80% v/v 에탄올 200 μl를 튜브에 첨가한 다음 30초 후에 에탄올을 제거하는 과정을 총 2회 반복하였다. 그 다음, 튜브의 뚜껑을 열고 샘플에 금(crack)이 생기기 전까지 에탄올 건조(ethanol dry)하였다.
샘플 튜브를 자성 분리 랙에서 꺼내, 멸균 3차 증류수를 첨가하여 원하는 농도로 DNA를 용리(elution)하였다. 자성 비드로부터 DNA를 분리시키기 위해, 상온에서 5분 동안 인큐베이션한 후 자성 분리 랙에 다시 장착하였다. 상층액이 투명해지면, 새로운 튜브에 상층액을 회수함으로써, 정제된 DNA를 수득하였다.
3-4: DNA QC
상기 실시예 3-3에서 수득한 정제된 DNA에 대해 Thermo Fisher Scientific사의 형광계(Qubit 4 Fluorometer)와 분광광도기(Spectrophotometer)를 이용하여 QC(Quality control, 품질 관리)를 수행하였고, 그 결과 양질의 DNA가 추출되었음을 확인하였다.
실시예 4. 유전체 분석을 위한 NGS 라이브러리 제작
WGS(whole genome sequencing) 진행을 위해, 상기 실시예 4에서 QC(Quality control) 기준을 통과한 양질의 gDNA샘플을 이용하여 리이브러리(library)를 제작하였다.
4-1: DNA 단편화 및 크기 선택
상기 실시예 3에서 QC 기준을 통과한 양질의 DNA를 100 bp 내지 1000 bp로 단편화(fragmentation)하고, 비드(Bead)를 사용해 Paired-End 150 라이브러리 제작이 가능하도록 300 bp 내지 500 bp의 크기 선택(size selection)을 진행하였다. 샘플 QC를 위한 자동화 전기 영동 도구인 Agilent사의 2100 Bioanalyzer로 선택된 gDNA의 크기(size)를 확인하였다. 또한, 다른 핵산이나 단백질로부터 이중-가닥 DNA를 고감도(high sensitivity)로 구별할 수 있는 dsDNA 정량을 위한 키트인 QubitTM dsDNA HS Assay kit(Thermo Fisher Scientific사)로 농도를 측정하였다.
4-2: 말단 수선(End Repair) 및 A-테일링(A-Tailing)
상기 실시예 4-1에서 선택된 300 bp 내지 500 bp 크기의 DNA 단편을 평활 말단(blunt end)으로 수선(repair)하였고, 3'말단에 dATP(deoxyadenosine triphosphate)를 붙이는 A-테일링을 수행하였다.
4-3: 어댑터 라이게이션(Adapter Ligation)
상기 실시예 4-2의 DNA 단편 끝에 dTTP (deoxythymidine triphosphate)가 테일링(tailing)된 어댑터(adapter)를 라이게이션(ligation, 결찰)하고, 플로우 셀(flow cell)에 처리하여 혼성화(hybridization)시켰다.
4-4: 라이브러리 QC
제작된 라이브러리(library)에 대해 Agilent사의 2100 Bioanalyzer system을 이용하여 품질(Quality)을 확인하였다. 총 50개체, 샘플 NFS_202100101 내지 NFS_202100116, 샘플 NFS_202100117 내지 NFS_202100302, 샘플 NFS_202100303 내지 NFS_202100406, 및 샘플 NFS_202100407 내지 NFS_202100408에 대한 라이브러리 제작 QC 결과는 Electronic ladder의 결과와 함께 각각 도 4 내지 도 7에 나타내었다.
4-5: PCR 증폭
어댑터(Adapter)와 라이게이션(ligation)된 생성물(product)을 PCR로 증폭하였다. 최종 PCR 산물의 크기를 Agilent 2100 Bioanalyzer 확인하였고, QubitTM dsDNA HS Assay kit로 농도를 측정한 후, 1 pmol (picomole) PCR 산물에 해당하는 나노 그램 단위의 양(Mass, ng)을 계산하였다.
4-6: 단일 가닥 원형화(Single Strand Circularization)
1 pmol의 PCR 산물을 열-변성(heat-denature)시켜 생겨난 단일-가닥 분자(single-strand molecule)를 DNA 연결효소(DNA ligase)로 라이게이션(ligation)시키고 남아 있는 선형 분자(linear molecule)는 핵산외부가수분해효소(exonuclease)로 분해(digest)시켰다. 단일 가닥 원형화 후 QC를 수행하였고, 그 결과 양질의 핵산을 수득하였음을 확인하였다.
실시예 5. NGS 플랫폼을 이용한 NGS 염기서열분석 데이터 생산 방법
상기 실시예 4-6의 단일 가닥 원형화 후, 다음과 같이 DNB(DNA nanoball)를 제작하고, 활성화 부위 당 오직 하나의 DNB만 결합하는, MGI Tech사의 고밀도 패턴화 나노어레이 플로우 셀(High density patterned nanoarray Flow cells)을 이용하여, DNB 염기서열분석을 진행하였다.
5-1: DNA 나노 볼(DNA nano ball) 제작
상기 실시예 4로부터 수득한, 40 fmol(femtomole)의 단일-가닥 원형 DNA 라이브러리(single-strand circular DNA library)와 프라이머(primer)를 혼성화(hybridization)시켰다. DNB Enzyme (Phi29, Φ29 DNA polymerase)을 이용한 RCA (Rolling Circle Amplification)를 15분간 수행한 후, QubitTM ssDNA Assay kit로 라이브러리 농도를 측정하였다.
5-2: DNB 풀링(Pooling) 계산
풀링(Pooling)할 샘플들의 농도 역수(concentration reciprocal)의 합계, 이들의 평균값 및 400/평균값인 Parameter B를 계산하여, 각 샘플들의 풀링 부피(pooling volume)를 확정하였다.
5-3: DNB 로딩 준비
MGI Tech사의 DNB Rapid Reagent kit에 있는 DNB Load Buffer I과 III를 이용해 DNB loading Mix를 준비하였다.
5-4: 플로우 셀 준비 및 DNB 로딩
MGI Tech사의 MGIDL-7에 플로우 셀(flow cell)과 DNB 로더(loader)의 바코드(barcode)를 인식시켜서 장착하였다. 상기 실시예 5-3에서 준비된 DNB loading Mix를 DNB 튜브 구멍에 넣은 후, 플로우 셀 로딩(Flow cell loading)을 시작하였다.
5-5: 염기서열분석
염기서열분석 카트리지(Sequencing Cartridge)와 세척 카트리지(Washing cartridge)를 염기서열분석 장비인 DNBSEQ-T7(MGI사)에 장착하고 DNB 로딩이 완료된 플로우(flow)를 인식시켜 염기서열분석(sequencing)을 진행하였다.
5-6: 염기서열분석 결과
아래 표 3에 나타낸 바와 같이, 50개체에서 추출한 DNA로부터 약 509억 개의 리드(read)(개체 별 평균: 10.18억 개의 리드)로부터 7,631 Gbp (giga base pairs, one billion nucleotides)(개체 별 평균: 152.6 Gbp)의 서열을 확보하였다.
아래 표 4에 나타낸 프레드 품질 점수(Phred quality score)와 같이, 생산된 50개체의 품질 점수 30 이상 비율(Q30)이 모두 80% 이상을 충족하여 고품질의 염기서열분석 데이터를 생산하였음을 확인하였다. 프레드 품질 점수는 각 염기 별 신뢰성을 표시한 품질 지표로, 각 서열을 얼마나 정확하게 읽었는지 판단하는 기준이다.
| Sample ID | Raw reads | ||||
|
Total
reads |
Total
bases (Gb) |
Q20 rate (%) | Q30 rate (%) |
Average
depth (x) |
|
| NFS_202100101 | 723,482,150 | 108.5 | 96.23 | 88.88 | 35.09 |
| NFS_202100102 | 796,923,086 | 119.5 | 95.47 | 86.25 | 38.65 |
| NFS_202100103 | 787,668,392 | 118.2 | 96.08 | 87.89 | 38.20 |
| NFS_202100104 | 682,420,690 | 102.4 | 96.16 | 88.56 | 33.10 |
| NFS_202100105 | 811,409,290 | 121.7 | 96.04 | 87.84 | 39.35 |
| NFS_202100106 | 818,285,838 | 122.7 | 96.10 | 87.98 | 39.69 |
| NFS_202100107 | 886,499,748 | 133.0 | 96.09 | 88.26 | 43.00 |
| NFS_202100108 | 848,005,100 | 127.2 | 96.25 | 88.59 | 41.13 |
| NFS_202100109 | 788,801,938 | 118.3 | 96.05 | 88.89 | 38.26 |
| NFS_202100110 | 936,842,428 | 140.5 | 96.26 | 88.66 | 45.44 |
| NFS_202100111 | 1,019,239,770 | 152.9 | 96.30 | 88.84 | 49.43 |
| NFS_202100112 | 893,577,410 | 134.0 | 95.51 | 86.53 | 43.34 |
| NFS_202100113 | 754,109,606 | 113.1 | 96.01 | 88.75 | 36.57 |
| NFS_202100114 | 965,425,112 | 144.8 | 96.12 | 88.32 | 46.82 |
| NFS_202100115 | 1,020,370,606 | 153.1 | 96.09 | 88.31 | 49.49 |
| NFS_202100116 | 892,958,634 | 133.9 | 96.03 | 88.12 | 43.31 |
| NFS_202100117 | 1,238,895,246 | 185.8 | 96.43 | 89.53 | 60.09 |
| NFS_202100118 | 1,060,983,826 | 159.1 | 96.19 | 89.07 | 51.46 |
| NFS_202100119 | 968,180,426 | 145.2 | 96.21 | 89.07 | 46.96 |
| NFS_202100120 | 790,678,754 | 118.6 | 95.68 | 88.38 | 38.35 |
| NFS_202100121 | 1,130,400,008 | 169.6 | 95.78 | 88.61 | 54.82 |
| NFS_202100201 | 813,812,158 | 122.1 | 95.95 | 89.22 | 39.47 |
| NFS_202100202 | 818,128,832 | 122.7 | 95.74 | 88.76 | 39.68 |
| NFS_202100203 | 823,461,120 | 123.5 | 95.95 | 89.33 | 39.94 |
| NFS_202100204 | 812,313,488 | 121.8 | 95.99 | 89.41 | 39.40 |
| NFS_202100205 | 1,000,703,726 | 150.1 | 96.05 | 89.24 | 48.53 |
| NFS_202100206 | 1,135,314,014 | 170.3 | 96.21 | 89.84 | 55.06 |
| NFS_202100207 | 1,142,387,172 | 171.4 | 96.07 | 89.35 | 55.41 |
| NFS_202100208 | 1,247,857,738 | 187.2 | 96.24 | 89.65 | 60.52 |
| NFS_202100209 | 1,233,019,906 | 185.0 | 96.33 | 89.69 | 59.80 |
| NFS_202100301 | 985,247,144 | 147.8 | 95.79 | 88.77 | 47.78 |
| NFS_202100302 | 865,518,204 | 129.8 | 96.04 | 89.57 | 41.98 |
| NFS_202100303 | 873,348,834 | 131.0 | 96.02 | 88.92 | 42.36 |
| NFS_202100304 | 1,053,161,592 | 158.0 | 95.95 | 88.85 | 51.08 |
| NFS_202100305 | 1,186,293,470 | 177.9 | 95.89 | 88.75 | 57.54 |
| NFS_202100306 | 1,492,126,138 | 223.8 | 96.05 | 89.06 | 72.37 |
| NFS_202100307 | 851,576,702 | 127.7 | 95.94 | 88.79 | 41.30 |
| NFS_202100308 | 980,949,832 | 147.1 | 95.14 | 86.81 | 47.58 |
| NFS_202100309 | 1,090,140,206 | 163.5 | 95.89 | 88.71 | 52.87 |
| NFS_202100310 | 1,135,750,584 | 170.4 | 95.93 | 88.47 | 55.08 |
| NFS_202100311 | 995,794,578 | 149.4 | 96.00 | 88.81 | 48.30 |
| NFS_202100312 | 922,069,014 | 138.3 | 96.05 | 89.05 | 44.72 |
| NFS_202100401 | 1,176,096,778 | 176.4 | 96.14 | 89.25 | 57.04 |
| NFS_202100402 | 1,068,813,494 | 160.3 | 95.99 | 88.86 | 51.84 |
| NFS_202100403 | 1,427,382,264 | 214.1 | 96.50 | 89.88 | 69.23 |
| NFS_202100404 | 1,240,363,992 | 186.1 | 96.99 | 91.16 | 60.16 |
| NFS_202100405 | 1,020,022,412 | 153.0 | 96.87 | 90.78 | 49.47 |
| NFS_202100406 | 1,688,541,332 | 253.3 | 97.30 | 92.01 | 81.89 |
| NFS_202100407 | 1,401,333,380 | 210.2 | 97.28 | 91.70 | 67.96 |
| NFS_202100408 | 1,579,637,052 | 236.9 | 97.23 | 91.75 | 76.61 |
| Phred quality score | 시퀀싱 오류 확률 |
| Q10 | 10% |
| Q20 | 1% |
| Q30 | 0.1% |
| Q40 | 0.01% |
고품질의 염기서열분석 데이터를 생산하였을 뿐만 아니라, 인간의 참조 유전체(reference genome)(약 3.09 Gbp) 기준 커버리지 깊이가 평균 49.35 배수(x)에 해당하는 서열을 생산하였다. 이는 각 샘플의 개체 별로 전체 유전체를 약 49번 읽은(리드한) 효과를 나타낸다. NGS 데이터를 이용한 정확한 유전체 분석을 위해서는 전체 유전체의 30배수 이상의 데이터가 필요한데, 본 발명에서 생산된 NGS 데이터의 경우 최소 33.09 배수 및 최대 81.89배수의 데이터가 생산되었다는 점에서 본 발명에 따른 NGS 데이터의 정확성을 확인할 수 있었다. 커버리지 깊이(depth of coverage)는 유전체 특정 영역에서 각 염기 위치별 평균 리드 수를 의미하고, 일반적으로 x 단위를 사용한다.
실시예 6. 유전체 분석
6-1: 염기서열분석 원시 데이터 품질 관리(Sequencing raw data QC)
DNBSEQ-T7으로 생산된 원시 데이터(Raw data)의 품질 관리를 위해 FastQC (Andrews, 2010) 프로그램을 통해 염기 품질(base quality) 분포를 분석하고 그 결과는 도 8a 내지 8m에 나타내었다.
어댑터 트리밍(adapter trimming) 및 품질 필터(quality filter) 분석을 수행함으로써, NGS로 생산된 염기서열분석 데이터의 어댑터 오염(adapter contamination) 서열과 저품질(low quality) 영역의 제거를 통해 고품질의 염기서열분석 데이터를 얻었다. 어댑터 트리밍과 품질 필터 분석 후, 클린 데이터(clean data)를 기준으로 하여 커버리지 깊이가 평균 49.1 배수(x)로 분석되었다. 그 결과는 아래 표 5에 나타내었다.
| Sample ID | Clean reads |
Clean read
depth(X) |
||
|
Total
bases (Gb) |
Q20 rate (%) | Q30 rate (%) | ||
| NFS_202100101 | 107.7 | 96.69 | 90.10 | 34.84 |
| NFS_202100102 | 119.1 | 96.64 | 89.75 | 38.51 |
| NFS_202100103 | 117.4 | 96.80 | 90.33 | 37.97 |
| NFS_202100104 | 101.7 | 96.72 | 90.10 | 32.87 |
| NFS_202100105 | 121.1 | 96.79 | 90.31 | 39.15 |
| NFS_202100106 | 122.1 | 96.67 | 89.94 | 39.49 |
| NFS_202100107 | 132.6 | 96.79 | 90.22 | 42.86 |
| NFS_202100108 | 126.7 | 96.08 | 88.36 | 40.97 |
| NFS_202100109 | 117.9 | 96.81 | 90.36 | 38.11 |
| NFS_202100110 | 140.1 | 96.78 | 90.24 | 45.30 |
| NFS_202100111 | 152.4 | 96.94 | 90.72 | 49.28 |
| NFS_202100112 | 133.7 | 96.84 | 90.39 | 43.23 |
| NFS_202100113 | 112.7 | 96.65 | 89.96 | 36.43 |
| NFS_202100114 | 144.5 | 96.76 | 90.23 | 46.72 |
| NFS_202100115 | 152.5 | 96.63 | 89.84 | 49.30 |
| NFS_202100116 | 133.4 | 96.69 | 89.88 | 43.13 |
| NFS_202100117 | 185.0 | 96.72 | 90.11 | 59.83 |
| NFS_202100118 | 158.6 | 95.98 | 88.18 | 51.28 |
| NFS_202100119 | 144.5 | 96.34 | 89.52 | 46.71 |
| NFS_202100120 | 118.4 | 95.82 | 87.94 | 38.28 |
| NFS_202100121 | 168.7 | 96.48 | 89.95 | 54.56 |
| NFS_202100201 | 121.7 | 96.47 | 90.00 | 39.33 |
| NFS_202100202 | 122.2 | 96.12 | 88.91 | 39.51 |
| NFS_202100203 | 123.2 | 96.26 | 89.24 | 39.82 |
| NFS_202100204 | 121.2 | 96.36 | 89.59 | 39.18 |
| NFS_202100205 | 149.4 | 95.54 | 87.17 | 48.32 |
| NFS_202100206 | 169.4 | 96.32 | 89.48 | 54.77 |
| NFS_202100207 | 170.3 | 96.34 | 89.50 | 55.05 |
| NFS_202100208 | 186.4 | 96.34 | 89.62 | 60.26 |
| NFS_202100209 | 184.2 | 95.56 | 87.58 | 59.56 |
| NFS_202100301 | 147.1 | 96.83 | 90.94 | 47.55 |
| NFS_202100302 | 129.3 | 96.75 | 90.67 | 41.79 |
| NFS_202100303 | 130.7 | 96.86 | 91.07 | 42.26 |
| NFS_202100304 | 157.4 | 96.72 | 90.67 | 50.89 |
| NFS_202100305 | 177.1 | 95.57 | 87.43 | 57.27 |
| NFS_202100306 | 223.2 | 96.64 | 90.46 | 72.18 |
| NFS_202100307 | 127.4 | 97.20 | 92.23 | 41.18 |
| NFS_202100308 | 146.5 | 96.83 | 91.21 | 47.37 |
| NFS_202100309 | 162.7 | 96.67 | 90.40 | 52.62 |
| NFS_202100310 | 169.8 | 96.26 | 89.16 | 54.92 |
| NFS_202100311 | 148.9 | 96.91 | 91.20 | 48.14 |
| NFS_202100312 | 137.5 | 96.75 | 90.75 | 44.46 |
| NFS_202100401 | 175.4 | 96.71 | 90.63 | 56.71 |
| NFS_202100402 | 159.6 | 96.93 | 91.24 | 51.60 |
| NFS_202100403 | 213.5 | 96.49 | 89.98 | 69.04 |
| NFS_202100404 | 185.6 | 96.68 | 90.58 | 60.01 |
| NFS_202100405 | 152.7 | 96.83 | 90.92 | 49.36 |
| NFS_202100406 | 252.6 | 96.82 | 90.92 | 81.69 |
| NFS_202100407 | 209.6 | 96.78 | 90.82 | 67.77 |
| NFS_202100408 | 236.4 | 96.56 | 90.21 | 76.44 |
이에 더하여, 기존에 Nova-Seq (Illumina사)으로 생산되었던 40개체의 데이터 또한 고품질의 염기서열분석 데이터를 추출하였다. 그 결과는 아래 표 6에 나타내었다.
| Sample ID | Clean reads |
Clean read
depth(X) |
||
|
Total
bases (Gb) |
Q20 rate (%) | Q30 rate (%) | ||
| 01-1 | 141.5 | 98.10 | 94.34 | 45.76 |
| 01-2 | 126.0 | 98.17 | 94.52 | 40.75 |
| 02-1 | 112.0 | 98.26 | 94.85 | 36.23 |
| 02-2 | 112.0 | 98.22 | 94.73 | 36.22 |
| 03-1 | 112.6 | 98.12 | 94.48 | 36.42 |
| 03-2 | 111.4 | 98.22 | 94.78 | 36.02 |
| 04-1 | 113.8 | 98.28 | 94.87 | 36.78 |
| 04-2 | 113.9 | 98.21 | 94.72 | 36.83 |
| 05-1 | 114.6 | 98.10 | 94.43 | 37.04 |
| 05-2 | 112.5 | 98.16 | 94.52 | 36.39 |
| 06-1 | 113.1 | 98.06 | 94.31 | 36.58 |
| 06-2 | 122.2 | 98.22 | 94.77 | 39.50 |
| 07-1 | 116.5 | 98.22 | 94.76 | 37.65 |
| 07-2 | 111.8 | 98.25 | 94.91 | 36.14 |
| 08-1 | 113.8 | 98.30 | 94.90 | 36.81 |
| 08-2 | 170.7 | 97.32 | 92.55 | 55.20 |
| 09-1 | 114.4 | 98.30 | 94.89 | 36.98 |
| 09-2 | 114.9 | 98.19 | 94.67 | 37.14 |
| 10-1 | 114.4 | 98.14 | 94.51 | 36.99 |
| 10-2 | 113.8 | 98.21 | 94.69 | 36.81 |
| 11-1 | 120.3 | 98.17 | 94.63 | 38.90 |
| 11-2 | 114.9 | 98.26 | 94.88 | 37.16 |
| 12-1 | 142.1 | 98.25 | 94.81 | 45.93 |
| 12-2 | 111.7 | 98.19 | 94.71 | 36.11 |
| 13-1 | 113.1 | 98.29 | 94.90 | 36.58 |
| 13-2 | 112.8 | 98.23 | 94.75 | 36.48 |
| 14-1 | 113.0 | 98.18 | 94.65 | 36.55 |
| 14-2 | 112.0 | 98.23 | 94.77 | 36.22 |
| 15-1 | 116.0 | 98.21 | 94.74 | 37.52 |
| 15-2 | 112.9 | 98.05 | 94.36 | 36.50 |
| 16-1 | 113.0 | 97.95 | 94.05 | 36.54 |
| 16-2 | 113.0 | 98.25 | 94.85 | 36.52 |
| 17-1 | 114.1 | 98.25 | 94.78 | 36.88 |
| 17-2 | 132.3 | 96.89 | 91.42 | 42.78 |
| 18-1 | 116.4 | 98.21 | 94.73 | 37.64 |
| 18-2 | 112.1 | 98.25 | 94.85 | 36.24 |
| 19-1 | 115.1 | 98.15 | 94.55 | 37.23 |
| 19-2 | 114.0 | 98.15 | 94.59 | 36.87 |
| 20-1 | 112.5 | 98.09 | 94.38 | 36.36 |
| 20-2 | 112.7 | 98.27 | 94.87 | 36.44 |
6-2: 서열 정렬(Sequence alignment)
품질 관리(Quality control) 후 클린 리드(clean read)을 이용하여 인간의 참조 유전체 (hg38, GRCh38) 서열(reference genome (hg38) sequence)에 BWA(Burrows-Wheeler Alignment)(Li H, 2013) 프로그램을 이용하여 서열 정렬을 수행하였다. 그 결과는 아래 표 7에 나타내었다.
표 7에 나타낸 바와 같이, 평균 74.8%의 정렬 비율(alignment rate)을 나타냈고, 평균 6.49%의 중복 비율(duplicate rate)을 보였다. 정렬 비율과 중복 비율의 결과를 토대로, 염기서열분석을 수행한 50개체의 진위 여부, 그리고 샘플링 및 라이브러리 제작의 이상 여부를 간접적으로 판단할 수 있다.
본 발명에서 염기서열분석을 수행한 50개체의 경우 대부분 정렬 비율이 낮은 편에 속하여, 해당 샘플에 대해서는 추가 실험이 진행되었으며, 이를 합하여 최종 통계를 계산하였다. 이 중에서 2개의 샘플(NFS_202100203및 NFS_202100204)은 이전 Nova-Seq으로 생산된 데이터를 활용하기로 하였으므로 2개 샘플에 대해서는 추가 생산하지 않았다.
| Sample ID |
Alignment
rate (%) |
Properly
aligned rate (%) |
Duplicates
rate (%) |
| NFS_202100101 | 83.82 | 82.03 | 5.15 |
| NFS_202100102 | 92.79 | 91.38 | 3.58 |
| NFS_202100103 | 84.42 | 82.83 | 5.31 |
| NFS_202100104 | 93.54 | 91.58 | 6.41 |
| NFS_202100105 | 64.39 | 63.15 | 4.84 |
| NFS_202100106 | 86.56 | 84.75 | 6.48 |
| NFS_202100107 | 80.34 | 78.79 | 4.14 |
| NFS_202100108 | 68.34 | 66.48 | 12.82 |
| NFS_202100109 | 85.1 | 83.17 | 8.17 |
| NFS_202100110 | 79.87 | 78.02 | 8.45 |
| NFS_202100111 | 68.17 | 66.31 | 8.47 |
| NFS_202100112 | 67.15 | 65.87 | 3.87 |
| NFS_202100113 | 81.03 | 78.95 | 8.58 |
| NFS_202100114 | 71.23 | 69.92 | 3.73 |
| NFS_202100115 | 66.38 | 65.17 | 4.16 |
| NFS_202100116 | 72.97 | 71.56 | 3.60 |
| NFS_202100117 | 73.23 | 72.06 | 4.54 |
| NFS_202100118 | 75.80 | 74.34 | 6.10 |
| NFS_202100119 | 86.62 | 84.82 | 4.09 |
| NFS_202100120 | 90.07 | 88.54 | 3.99 |
| NFS_202100121 | 72.54 | 71.33 | 5.04 |
| NFS_202100201 | 84.45 | 82.74 | 4.06 |
| NFS_202100202 | 83.33 | 81.5 | 7.81 |
| NFS_202100203 | 61.13 | 59.57 | 4.77 |
| NFS_202100204 | 85.27 | 83.48 | 6.11 |
| NFS_202100205 | 76.09 | 74.64 | 12.13 |
| NFS_202100206 | 70.05 | 68.8 | 34.29 |
| NFS_202100207 | 71.50 | 70.24 | 12.38 |
| NFS_202100208 | 69.22 | 68.21 | 6.68 |
| NFS_202100209 | 71.86 | 70.68 | 7.28 |
| NFS_202100301 | 74.35 | 73.18 | 4.96 |
| NFS_202100302 | 80.05 | 78.35 | 5.43 |
| NFS_202100303 | 71.02 | 69.59 | 4.97 |
| NFS_202100304 | 70.27 | 68.51 | 6.94 |
| NFS_202100305 | 69.33 | 67.87 | 5.84 |
| NFS_202100306 | 54.22 | 53.52 | 2.77 |
| NFS_202100307 | 70.49 | 69.13 | 5.56 |
| NFS_202100308 | 77.34 | 75.99 | 3.70 |
| NFS_202100309 | 84.70 | 83.34 | 4.47 |
| NFS_202100310 | 77.55 | 76.13 | 3.60 |
| NFS_202100311 | 77.23 | 76.04 | 4.30 |
| NFS_202100312 | 77.53 | 76.14 | 5.19 |
| NFS_202100401 | 57.71 | 56.41 | 5.99 |
| NFS_202100402 | 72.57 | 71.08 | 7.42 |
| NFS_202100403 | 73.26 | 71.93 | 3.22 |
| NFS_202100404 | 67.34 | 65.42 | 3.53 |
| NFS_202100405 | 73.33 | 70.59 | 4.94 |
| NFS_202100406 | 35.16 | 34.55 | 4.81 |
| NFS_202100407 | 55.87 | 54.67 | 5.43 |
| NFS_202100408 | 51.43 | 50.64 | 3.38 |
이에 더하여, 아래 표 8에 나타낸 바와 같이, 기존에 Nova-Seq으로 생산되었던 40개체의 데이터는 평균 95.5%의 정렬 비율을 보였고, 평균 10.9%의 중복 비율을 나타내었다.
| Sample ID |
Alignment
rate (%) |
Properly
aligned rate (%) |
Duplicates
rate (%) |
| 01-1 | 82.08 | 80.45 | 11.24 |
| 01-2 | 86.74 | 85.17 | 10.6 |
| 02-1 | 98.1 | 95.82 | 10.22 |
| 02-2 | 99.68 | 97.53 | 11.21 |
| 03-1 | 96.14 | 93.86 | 11.58 |
| 03-2 | 98.62 | 94.71 | 10.62 |
| 04-1 | 97.54 | 95.52 | 11.46 |
| 04-2 | 97.98 | 96.01 | 10.47 |
| 05-1 | 93.36 | 91.26 | 10.68 |
| 05-2 | 95.85 | 94.03 | 12.06 |
| 06-1 | 99.01 | 96.89 | 10.84 |
| 06-2 | 91.99 | 87.09 | 10.35 |
| 07-1 | 98.66 | 96.04 | 11.54 |
| 07-2 | 99.53 | 95.3 | 11.36 |
| 08-1 | 91.07 | 89.35 | 11.23 |
| 08-2 | 66.66 | 64.42 | 9.99 |
| 09-1 | 94.55 | 92.96 | 11.09 |
| 09-2 | 99.23 | 96.88 | 10.38 |
| 10-1 | 99.33 | 97.28 | 11.23 |
| 10-2 | 99.17 | 97.41 | 10.56 |
| 11-1 | 99.81 | 97.85 | 12.9 |
| 11-2 | 99.7 | 97.33 | 10.37 |
| 12-1 | 81.8 | 79.61 | 10.58 |
| 12-2 | 98.01 | 95.4 | 10.03 |
| 13-1 | 97.14 | 95.5 | 11.41 |
| 13-2 | 99.43 | 97.44 | 10.25 |
| 14-1 | 99.65 | 97.38 | 11.8 |
| 14-2 | 99.66 | 97.7 | 10.73 |
| 15-1 | 97.98 | 95.56 | 10.76 |
| 15-2 | 99.66 | 96.96 | 10.7 |
| 16-1 | 98.23 | 96.1 | 10.63 |
| 16-2 | 96.29 | 93.35 | 10.74 |
| 17-1 | 91.78 | 89.81 | 11.09 |
| 17-2 | 93.57 | 91.49 | 8.97 |
| 18-1 | 98.7 | 96.66 | 12.6 |
| 18-2 | 99.25 | 96.7 | 10.1 |
| 19-1 | 93.81 | 91.88 | 10.8 |
| 19-2 | 96.12 | 93.68 | 11.05 |
| 20-1 | 98.11 | 96.42 | 11.17 |
| 20-2 | 95.13 | 92.78 | 11.06 |
6-3: BAM (Binary sequence Alignment/Map) 파일 추출
인간의 참조 유전체 서열에 정렬한 결과 파일(BAM format, Binary sequence Alignment/Map format)을 이용하기 위하여, i) Nova-Seq으로 생산된 40개체 및 ii) DNBSEQ-T7으로 생산된 48개체 및 Nova-Seq으로 생산된 2개체를 도 9에 나타낸 파이프라인 모식도의 순서대로 분석하였다.
BAM 파일은 SAM 파일의 바이너리(이진법) 버전의 파일로, 리드의 참조 유전체 정렬 결과를 포함하는 파일 포맷이다. SAM 파일(SAM file, Sequence Alignment/Map format File)은 서열이 참조 유전체(reference genome)의 특정 위치에 맵핑된 정보를 포함하는, 탭으로 구분된 텍스트 형태의 파일로 header와 alignment 파트로 구성되는 파일이다. Header 파트는 버전, 정렬 유무, 길이 등의 정보를 포함하며, alignment 파트는 서열 정보와 그에 대한 품질 등의 정보를 포함한다. 맵핑(mapping)은 정렬(alignment)과 같은 의미로 사용하며, 참조 유전체와 비교하여 해당 리드의 유전체상 원래 위치를 추정하는 단계를 의미한다.
실시예 7. 친족관계 확인 분석
상술한 실시예 2의 SNP 패널을 이용하여, 상술한 실시예 6에서 염기서열분석 결과 수득한 BAM 파일로부터 친족관계 예측 분석을 수행하였다. 실시예 2에서 기술하였듯이, 본 발명자들은 서로 관계가 없는 88 개체의 한국인으로부터 생성한 한국 표준 참조 변이체인 KoVariome에서 918개 및 482개 SNP 마커를 추출하였다. 이러한 SNP 마커가 서로 1촌 내지 4촌 관계에 있는, 즉 서로 친족관계인 90 개체의 한국인에서 한국인 친족관계 예측에 유용한지 다음과 같이 확인하였다.
아래 표 9에 나타낸 바와 같이, first degree relative (first-d-r)은 본인을 기준으로 부모, 형제, 자매, 남매 및 자식 중 하나의 요건을 충족하는 경우이고, second degree relative (second-d-r)은 본인을 기준으로 이모, 삼촌, 고모, 할아버지, 할머니, 부모 한쪽이 다른 형제, 자매, 및 남매 중 하나의 요건을 충족하는 경우이며, third degree relative (third-d-r)는 본인을 기준으로 친사촌 관계인 경우이고, 관계없음(unrelated)은 상술한 first-d-r, second-d-r, 및 third-d-r에 속하는 관계가 아닌 경우이다.
| 구분 | 관계 |
| First degree relative | 부모, 형제, 자매, 남매, 자식 중 하나 |
| Second degree relatives | 이모, 삼촌, 고모, 할아버지, 할머니, 부모 한쪽이 다른 형제, 자매, 또는 남매 중 하나 |
| Third degree relatives | 친사촌 (First cousins) |
| 관계없음(Unrelated) | - |
IBS(Identity by state) 테스트를 이용하여, 먼저 i) Nova-Seq으로 생산되었던 40개체의 친족 관계를 확인하였고, 그 다음에는, ii) DNBSEQ-T7으로 생산된 48개체와 Nova-Seq으로 생산된 2개체의 친족 관계를 확인하였다.
아래 표 10에 나타낸 바와 같이, IBS 테스트는 각 샘플들이 친족 관계에 있는지 측정할 수 있는 분석 방법으로, 인간 기준으로 IBS 테스트 결과 평균 IBS 점수가 1이면 동일 개체 혹은 일란성 쌍둥이, 0.5이면 부모 자식의 관계 또는 형제 간의 관계, 0.25이면 3촌 이내 관계, 0.125이면 4촌 이내 관계로 판단할 수 있다(Anderson C. A. et al., 2010, Nat Protoc.).
| 한국 촌수 기준 | 관계 | 평균 IBS 점수 |
| - | 동일 개체 | 1.0 |
| - | 일란성 쌍둥이 | 1.0 (0.5) |
| 1촌 | 부모-자식 | 0.5 (0.25) |
| 2촌 | 친형제 (Full siblings) | 0.5 |
| 3촌 | 배다른 형제 (Half siblings) | 0.25 |
| 4촌 | 친사촌 (First cousins) | 0.125 |
| - | 관계없음 (Unrelated) | 0 |
7-1: IBS 테스트
IBS 테스트는, 염기서열분석 데이터로부터 관련성(relatedness)을 빠르게 평가할 수 있는 도구인, Somalier 프로그램(Pedersen et al. 2020)을 이용하여 상술한 실시예 6에서 기 추출된 BAM 파일인, i) Nova-Seq으로 생산된 40개체의 데이터, 또는 ii) DNBSEQ-T7으로부터 생산된 48개체 및 Nova-Seq으로 생산된 2개체의 데이터로부터 a) 상술한 실시예 2-1에 따른 918개의 SNP 패널의 변이, 또는 b) 상술한 실시예 2-2에 따른 482개의 SNP 패널의 변이에 대해 계산되었다.
Somalier 프로그램을 이용한 IBS 테스트에 의한 근연도 값 계산 방법은 Pedersen et al. 2020에 상세히 개시되어 있다. Somalier 프로그램은 각 샘플의 서열이 정렬된 BAM 파일 또는 VCF(variant call format) 파일로부터 직접 수득한 변이 정보를 추출하고 비교하여, 샘플 사이에서 쌍방 관계를 평가한다. 정렬된 서열들은 특정 위치에서 쌍방 관계가 평가되는데, 해당 특정 위치의 정렬된 염기는 주어진 참조(reference) 염기와 조사하고자 하는 변이의 선택적(alternate) 염기, 즉 참조 염기와 상이한 염기에 대해 확인한다.
간략하게, 두 대상을 쌍으로(pairwise) 비교해 두 대립유전자에서 해당 SNP 염기 종류가 모두 동일한 경우 IBS 점수 2 (Identity by state 2)로 지정하고, 해당 SNP 염기 종류가 하나만 동일한 경우 IBS 점수 1로 지정하고, 해당 SNP 염기 종류가 모두 상이한 경우 IBS 점수 0으로 지정하였다. 그 다음으로, 쌍으로 비교한 모든 SNP에 대한 IBS 평균을 산출하였다.
일반적으로, 이러한 IBS 테스트 결과 평균 IBS 점수가 약 1이면 동일 개체 혹은 일란성 쌍둥이, 약 0.5이면 부모 자식의 관계 또는 형제 간의 관계인 2촌 이하의 first-d-r, 약 0.25이면 3촌 관계인 second-d-r, 약 0.125이면 4촌 관계인 third-d-r, 약 0 부근의 값이면 서로 관계없음 또는 친족관계 아님(unrelated)으로 판단한다.
본 발명에 따른 한국인 친족관계 확인을 위한 918개 SNP 마커 및 482개 SNP 마커를 각각 이용해, 실제 한국 촌수 기준 1촌 내지 4촌 관계에 있는 한국인 집단에서 두 대상 사이의 평균 IBS 점수를 산출하고, first-d-r, second-d-r 및 unrelated 그룹으로 나누거나, 또는 first-d-r, second-d-r, third-d-r 및 unrelated 그룹으로 나누어, 친족관계인 개체를 친족관계가 아닌 개체로부터 구별할 수 있는지 여부를 후술될 실시예에서 확인하였다.
7-2: 918개의 SNP 패널을 이용한 IBS 테스트 분석
7-2-1: Nova-Seq으로 생산된 40개체에 대한 친족관계 분석
상술한 실시예 7-1에 나타낸 바와 같이 IBS 테스트는, 염기서열분석 데이터로부터 관련성(relatedness)을 빠르게 평가할 수 있는 도구인, Somalier 프로그램 (Pedersen et al. 2020)을 이용하여 기 추출된 BAM 파일로부터 상술한 실시예 2-1에 따른 918개의 SNP 마커의 변이에 대하여 계산되었다. 918개의 SNP 마커를 이용한 Nova-Seq으로 생산된 40개체의 IBS 테스트 결과 근연도 값을 비교 매트릭스로 도 10에 나타내었다.
아래 표 11에는 두 개체 사이의 평균 IBS 점수와 실제 친족관계를 나타내었고, 도 11에는 First-d-r, Second-d-r 및 나머지(other) 그룹으로 나누어 그룹별로 평균 IBS 점수를 나타내었다. 그 결과, First degree relative의 평균 IBS 점수는 0.501 (0.382 내지 0.574)이며, Second degree relative의 평균 IBS 점수는 0.226 (0.166 내지 0.299)이었다. 그리고 관련이 없는 개체(unrelated, other)에 대한 평균 IBS 점수는 -0.014 (-0.193 내지 0.144)이었다.
본 발명자들은 First-d-r의 평균 IBS 점수가 위치한 버퍼(buffer) 영역인 0.382 내지 0.574와 Second-d-r의 평균 IBS 점수가 위치한 버퍼 영역인 0.166 내지 0.299가 서로 겹치지 않는다는 데이터로부터, 총 40명의 한국인 가족관계에 상술한 실시예 2-1에 따른 918개의 SNP 패널을 적용하였을 때, First-d-r와 First-d-r아닌 남을 명확하게 구분할 뿐만 아니라, First-d-r와 Second-d-r를 서로 구별할 수 있음을 확인할 수 있었다.
| 샘플 1 | 샘플 2 | IBS | Degree |
| 01-1 | 01-2 | 0.50 | First |
| 01-1 | 02-1 | 0.17 | Second |
| 01-1 | 02-2 | 0.51 | First |
| 01-2 | 02-1 | 0.18 | Second |
| 01-2 | 02-2 | 0.50 | First |
| 02-1 | 02-2 | 0.45 | First |
| 03-1 | 03-2 | 0.38 | First |
| 04-1 | 04-2 | 0.55 | First |
| 05-1 | 05-2 | 0.53 | First |
| 06-1 | 06-2 | 0.53 | First |
| 07-1 | 07-2 | 0.57 | First |
| 08-1 | 08-2 | 0.49 | First |
| 09-1 | 09-2 | 0.44 | First |
| 10-1 | 10-2 | 0.53 | First |
| 11-1 | 11-2 | 0.57 | First |
| 11-1 | 14-1 | 0.52 | First |
| 11-1 | 14-2 | 0.52 | First |
| 11-2 | 14-1 | 0.30 | Second |
| 11-2 | 14-2 | 0.26 | Second |
| 12-1 | 12-2 | 0.50 | First |
| 13-1 | 13-2 | 0.57 | First |
| 14-1 | 14-2 | 0.54 | First |
| 15-1 | 15-2 | 0.48 | First |
| 16-1 | 16-2 | 0.47 | First |
| 17-1 | 17-2 | 0.47 | First |
| 18-1 | 18-2 | 0.57 | First |
| 19-1 | 19-2 | 0.39 | First |
| 20-1 | 20-2 | 0.43 | First |
7-2-2: DNBSEQ-T7으로 생산된 48개체 및 Nova-Seq으로 생산된 2개체에 대한 친족관계 분석
그 다음, DNBSEQ-T7으로부터 생산된 48개체의 데이터와 Nova-Seq으로 생산된 2개체의 데이터를 이용하여 IBS값을 계산하였다. 918개의 SNP 패널을 이용한 50개체의 IBS 테스트에 의한 근연도 값을 비교 매트릭스로 도 12에 나타내었다.
아래 표 12 내지 표 14에는 각각 First-d-r, Second-d-r 및 Third-d-r 관계에 있는 두 개체 사이의 IBS 점수를 나타내었고, 도 13에는 First-d-r, Second-d-r, Third-d-r 및 나머지(other) 그룹별 평균 IBS 점수를 나타내었다. 그 결과, First-d-r의 평균 IBS 점수는 0.508 (0.413 내지 0.635)이었고, Second-d-r의 평균 IBS 점수는 0.253 (0.087 내지 0.378)이었으며, Third-d-r의 평균 IBS 점수는 0.136 (-0.024 내지 0.273)이었다. 마지막으로 서로 관련이 없는 두 개체(Unrelated, other) 사이에서 평균 IBS 점수는 0.025 (-0.187 내지 0.263)이었다.
본 발명자들은 First-d-r의 IBS 점수가 위치한 버퍼 영역인 0.413 내지 0.635와 Second-d-r의 IBS 점수가 위치한 버퍼 영역인 0.087 내지 0.378가 서로 겹치지 않는다는 데이터로부터, 총 50명의 한국인 가족관계에 상술한 실시예 2-1에 따른 918개의 SNP 패널을 적용하였을 때, First-d-r와 First-d-r가 아닌 남을 명확하게 구분이 가능할 뿐만 아니라, First-d-r와 Second-d-r를 서로 구별할 수 있음을 확인할 수 있었다.
| Degree | 샘플 1 | 샘플 2 | IBS | 샘플 1 | 샘플 2 | IBS |
| First degree relative | NFS_202100101 | NFS_202100103 | 0.535 | NFS_202100121 | NFS_202100120 | 0.531 |
| NFS_202100101 | NFS_202100107 | 0.499 | NFS_202100203 | NFS_202100201 | 0.475 | |
| NFS_202100101 | NFS_202100112 | 0.52 | NFS_202100203 | NFS_202100202 | 0.47 | |
| NFS_202100101 | NFS_202100116 | 0.508 | NFS_202100204 | NFS_202100203 | 0.527 | |
| NFS_202100102 | NFS_202100103 | 0.528 | NFS_202100204 | NFS_202100201 | 0.529 | |
| NFS_202100102 | NFS_202100107 | 0.47 | NFS_202100204 | NFS_202100202 | 0.508 | |
| NFS_202100102 | NFS_202100112 | 0.501 | NFS_202100205 | NFS_202100207 | 0.512 | |
| NFS_202100102 | NFS_202100116 | 0.485 | NFS_202100205 | NFS_202100202 | 0.527 | |
| NFS_202100103 | NFS_202100105 | 0.492 | NFS_202100206 | NFS_202100207 | 0.46 | |
| NFS_202100103 | NFS_202100106 | 0.492 | NFS_202100207 | NFS_202100209 | 0.527 | |
| NFS_202100103 | NFS_202100107 | 0.413 | NFS_202100208 | NFS_202100209 | 0.515 | |
| NFS_202100103 | NFS_202100112 | 0.635 | NFS_202100301 | NFS_202100304 | 0.513 | |
| NFS_202100103 | NFS_202100116 | 0.456 | NFS_202100301 | NFS_202100305 | 0.549 | |
| NFS_202100104 | NFS_202100105 | 0.515 | NFS_202100301 | NFS_202100303 | 0.527 | |
| NFS_202100104 | NFS_202100106 | 0.475 | NFS_202100302 | NFS_202100303 | 0.511 | |
| NFS_202100105 | NFS_202100106 | 0.43 | NFS_202100302 | NFS_202100307 | 0.506 | |
| NFS_202100107 | NFS_202100109 | 0.462 | NFS_202100304 | NFS_202100305 | 0.541 | |
| NFS_202100107 | NFS_202100110 | 0.496 | NFS_202100304 | NFS_202100302 | 0.511 | |
| NFS_202100107 | NFS_202100111 | 0.525 | NFS_202100304 | NFS_202100303 | 0.527 | |
| NFS_202100107 | NFS_202100112 | 0.446 | NFS_202100305 | NFS_202100302 | 0.526 | |
| NFS_202100107 | NFS_202100116 | 0.558 | NFS_202100305 | NFS_202100303 | 0.527 | |
| NFS_202100108 | NFS_202100109 | 0.5 | NFS_202100306 | NFS_202100310 | 0.552 | |
| NFS_202100108 | NFS_202100110 | 0.518 | NFS_202100308 | NFS_202100306 | 0.519 | |
| NFS_202100108 | NFS_202100111 | 0.523 | NFS_202100308 | NFS_202100310 | 0.548 | |
| NFS_202100109 | NFS_202100110 | 0.513 | NFS_202100308 | NFS_202100307 | 0.51 | |
| NFS_202100109 | NFS_202100111 | 0.483 | NFS_202100309 | NFS_202100312 | 0.534 | |
| NFS_202100110 | NFS_202100111 | 0.585 | NFS_202100310 | NFS_202100307 | 0.506 | |
| NFS_202100112 | NFS_202100114 | 0.526 | NFS_202100311 | NFS_202100309 | 0.526 | |
| NFS_202100112 | NFS_202100115 | 0.527 | NFS_202100311 | NFS_202100312 | 0.569 | |
| NFS_202100112 | NFS_202100116 | 0.449 | NFS_202100311 | NFS_202100310 | 0.563 | |
| NFS_202100113 | NFS_202100114 | 0.513 | NFS_202100312 | NFS_202100310 | 0.54 | |
| NFS_202100113 | NFS_202100115 | 0.518 | NFS_202100401 | NFS_202100403 | 0.521 | |
| NFS_202100114 | NFS_202100115 | 0.549 | NFS_202100401 | NFS_202100404 | 0.531 | |
| NFS_202100118 | NFS_202100117 | 0.455 | NFS_202100402 | NFS_202100403 | 0.478 | |
| NFS_202100118 | NFS_202100116 | 0.49 | NFS_202100402 | NFS_202100404 | 0.467 | |
| NFS_202100119 | NFS_202100121 | 0.446 | NFS_202100403 | NFS_202100404 | 0.442 | |
| NFS_202100119 | NFS_202100101 | 0.476 | NFS_202100405 | NFS_202100401 | 0.599 | |
| NFS_202100119 | NFS_202100102 | 0.452 | NFS_202100405 | NFS_202100407 | 0.522 | |
| NFS_202100119 | NFS_202100103 | 0.495 | NFS_202100405 | NFS_202100408 | 0.519 | |
| NFS_202100119 | NFS_202100107 | 0.453 | NFS_202100406 | NFS_202100407 | 0.482 | |
| NFS_202100119 | NFS_202100112 | 0.489 | NFS_202100406 | NFS_202100408 | 0.52 | |
| NFS_202100119 | NFS_202100116 | 0.485 | NFS_202100407 | NFS_202100408 | 0.521 |
| Degree | 샘플 1 | 샘플 2 | IBS | 샘플 1 | 샘플 2 | IBS |
| Second degree relative | NFS_202100101 | NFS_202100105 | 0.206 | NFS_202100118 | NFS_202100102 | 0.306 |
| NFS_202100101 | NFS_202100106 | 0.23 | NFS_202100118 | NFS_202100103 | 0.225 | |
| NFS_202100101 | NFS_202100109 | 0.249 | NFS_202100118 | NFS_202100107 | 0.272 | |
| NFS_202100101 | NFS_202100110 | 0.326 | NFS_202100118 | NFS_202100112 | 0.161 | |
| NFS_202100101 | NFS_202100111 | 0.302 | NFS_202100119 | NFS_202100105 | 0.087 | |
| NFS_202100101 | NFS_202100114 | 0.279 | NFS_202100119 | NFS_202100106 | 0.21 | |
| NFS_202100101 | NFS_202100115 | 0.309 | NFS_202100119 | NFS_202100109 | 0.168 | |
| NFS_202100102 | NFS_202100105 | 0.289 | NFS_202100119 | NFS_202100110 | 0.2 | |
| NFS_202100102 | NFS_202100106 | 0.271 | NFS_202100119 | NFS_202100111 | 0.237 | |
| NFS_202100102 | NFS_202100109 | 0.208 | NFS_202100119 | NFS_202100114 | 0.158 | |
| NFS_202100102 | NFS_202100110 | 0.216 | NFS_202100119 | NFS_202100115 | 0.212 | |
| NFS_202100102 | NFS_202100111 | 0.245 | NFS_202100121 | NFS_202100101 | 0.292 | |
| NFS_202100102 | NFS_202100114 | 0.183 | NFS_202100121 | NFS_202100102 | 0.223 | |
| NFS_202100102 | NFS_202100115 | 0.232 | NFS_202100121 | NFS_202100103 | 0.288 | |
| NFS_202100103 | NFS_202100109 | 0.122 | NFS_202100121 | NFS_202100107 | 0.223 | |
| NFS_202100103 | NFS_202100110 | 0.281 | NFS_202100121 | NFS_202100112 | 0.286 | |
| NFS_202100103 | NFS_202100111 | 0.259 | NFS_202100121 | NFS_202100116 | 0.238 | |
| NFS_202100103 | NFS_202100114 | 0.303 | NFS_202100203 | NFS_202100205 | 0.214 | |
| NFS_202100103 | NFS_202100115 | 0.367 | NFS_202100204 | NFS_202100205 | 0.272 | |
| NFS_202100105 | NFS_202100107 | 0.154 | NFS_202100205 | NFS_202100209 | 0.372 | |
| NFS_202100105 | NFS_202100112 | 0.33 | NFS_202100206 | NFS_202100209 | 0.199 | |
| NFS_202100105 | NFS_202100116 | 0.175 | NFS_202100207 | NFS_202100202 | 0.279 | |
| NFS_202100106 | NFS_202100107 | 0.177 | NFS_202100303 | NFS_202100307 | 0.297 | |
| NFS_202100106 | NFS_202100112 | 0.354 | NFS_202100304 | NFS_202100307 | 0.256 | |
| NFS_202100106 | NFS_202100116 | 0.216 | NFS_202100305 | NFS_202100307 | 0.301 | |
| NFS_202100107 | NFS_202100114 | 0.217 | NFS_202100308 | NFS_202100312 | 0.343 | |
| NFS_202100107 | NFS_202100115 | 0.265 | NFS_202100308 | NFS_202100302 | 0.27 | |
| NFS_202100109 | NFS_202100112 | 0.232 | NFS_202100310 | NFS_202100302 | 0.304 | |
| NFS_202100109 | NFS_202100116 | 0.272 | NFS_202100311 | NFS_202100308 | 0.32 | |
| NFS_202100110 | NFS_202100112 | 0.237 | NFS_202100311 | NFS_202100306 | 0.304 | |
| NFS_202100110 | NFS_202100116 | 0.309 | NFS_202100311 | NFS_202100307 | 0.251 | |
| NFS_202100111 | NFS_202100112 | 0.254 | NFS_202100312 | NFS_202100306 | 0.378 | |
| NFS_202100111 | NFS_202100116 | 0.333 | NFS_202100312 | NFS_202100307 | 0.211 | |
| NFS_202100114 | NFS_202100116 | 0.205 | NFS_202100401 | NFS_202100407 | 0.331 | |
| NFS_202100115 | NFS_202100116 | 0.233 | NFS_202100401 | NFS_202100408 | 0.324 | |
| NFS_202100118 | NFS_202100119 | 0.155 | NFS_202100405 | NFS_202100403 | 0.289 | |
| NFS_202100118 | NFS_202100101 | 0.194 | NFS_202100405 | NFS_202100404 | 0.267 |
| Degree | 샘플 1 | 샘플 2 | IBS | 샘플 1 | 샘플 2 | IBS |
| Third degree relative | NFS_202100105 | NFS_202100109 | 0.014 | NFS_202100118 | NFS_202100115 | 0.103 |
| NFS_202100105 | NFS_202100110 | 0.093 | NFS_202100121 | NFS_202100105 | 0.072 | |
| NFS_202100105 | NFS_202100111 | 0.083 | NFS_202100121 | NFS_202100106 | 0.108 | |
| NFS_202100105 | NFS_202100114 | 0.15 | NFS_202100121 | NFS_202100109 | 0.143 | |
| NFS_202100105 | NFS_202100115 | 0.175 | NFS_202100121 | NFS_202100110 | 0.131 | |
| NFS_202100106 | NFS_202100109 | -0.024 | NFS_202100121 | NFS_202100111 | 0.137 | |
| NFS_202100106 | NFS_202100110 | 0.144 | NFS_202100121 | NFS_202100114 | 0.154 | |
| NFS_202100106 | NFS_202100111 | 0.12 | NFS_202100121 | NFS_202100115 | 0.169 | |
| NFS_202100106 | NFS_202100114 | 0.143 | NFS_202100203 | NFS_202100207 | 0.119 | |
| NFS_202100106 | NFS_202100115 | 0.164 | NFS_202100204 | NFS_202100207 | 0.112 | |
| NFS_202100109 | NFS_202100114 | 0.103 | NFS_202100209 | NFS_202100202 | 0.232 | |
| NFS_202100109 | NFS_202100115 | 0.114 | NFS_202100304 | NFS_202100308 | 0.151 | |
| NFS_202100110 | NFS_202100114 | 0.101 | NFS_202100304 | NFS_202100310 | 0.162 | |
| NFS_202100110 | NFS_202100115 | 0.164 | NFS_202100305 | NFS_202100310 | 0.273 | |
| NFS_202100111 | NFS_202100114 | 0.173 | NFS_202100308 | NFS_202100305 | 0.247 | |
| NFS_202100111 | NFS_202100115 | 0.208 | NFS_202100308 | NFS_202100303 | 0.225 | |
| NFS_202100118 | NFS_202100121 | 0.077 | NFS_202100310 | NFS_202100303 | 0.215 | |
| NFS_202100118 | NFS_202100105 | 0.069 | NFS_202100311 | NFS_202100302 | 0.167 | |
| NFS_202100118 | NFS_202100106 | 0.086 | NFS_202100312 | NFS_202100302 | 0.149 | |
| NFS_202100118 | NFS_202100109 | 0.153 | NFS_202100403 | NFS_202100407 | 0.184 | |
| NFS_202100118 | NFS_202100110 | 0.18 | NFS_202100403 | NFS_202100408 | 0.192 | |
| NFS_202100118 | NFS_202100111 | 0.206 | NFS_202100404 | NFS_202100407 | 0.09 | |
| NFS_202100118 | NFS_202100114 | 0.06 | NFS_202100404 | NFS_202100408 | 0.095 | |
| NFS_202100118 | NFS_202100114 | 0.06 | NFS_202100118 | NFS_202100115 | 0.103 |
7-3: 482개의 SNP 패널을 이용한 IBS 테스트 분석
7-3-1: Nova-Seq으로 생산된 40개체에 대한 친족관계 분석
IBS 테스트는 Somalier 프로그램을 이용하여 Nova-Seq으로 생산된 40개체의 BAM 파일로부터 상술한 실시예 2-2에 따른 482개의 SNP 패널의 변이에 대하여 계산되었다. 482개의 SNP 패널을 이용한 40개체 IBS 테스트에 의한 IBS 점수를 비교 매트릭스로 도 14에 나타내었다.
아래 표 15에는 두 개체 사이의 평균 IBS 점수와 실제 친족관계를 나타내었고, 도 15에는 First-d-r, Second-d-r 및 나머지(other) 그룹으로 나누어 그룹별로 평균 IBS 점수를 나타내었다. 그 결과, First-d-r의 평균 IBS 점수는 0.496 (0.340 내지 0.620)이었고, Second-d-r의 평균 IBS 점수는 0.233 (0.175 내지 0.309)이었다. 그리고 서로 관련이 없는 두 개체(unrelated, other) 사이에서 평균 IBS 점수는 -0.02 (-0.277 내지 0.175)이었다.
본 발명자들은 First-d-r의 근연도 값이 위치한 버퍼 영역인 0.340 내지 0.620와 Second-d-r의 근연도 값이 위치한 버퍼 영역인 0.175 내지 0.309가 서로 겹치지 않는다는 데이터로부터, 총 40명의 한국인 가족관계에 상술한 실시예 2-2에 따른 482개의 SNP 패널을 적용하였을 때, first degree relative 및 남을 명확하게 구분이 가능함을 확인하였다.
| 샘플 1 | 샘플 2 | IBS | Degree |
| 01-1 | 01-2 | 0.58 | First |
| 01-1 | 02-1 | 0.17 | Second |
| 01-1 | 02-2 | 0.52 | First |
| 01-2 | 02-1 | 0.2 | Second |
| 01-2 | 02-2 | 0.55 | First |
| 02-1 | 02-2 | 0.35 | First |
| 03-1 | 03-2 | 0.44 | First |
| 04-1 | 04-2 | 0.6 | First |
| 05-1 | 05-2 | 0.53 | First |
| 06-1 | 06-2 | 0.53 | First |
| 07-1 | 07-2 | 0.62 | First |
| 08-1 | 08-2 | 0.47 | First |
| 09-1 | 09-2 | 0.45 | First |
| 10-1 | 10-2 | 0.49 | First |
| 11-1 | 11-2 | 0.59 | First |
| 11-1 | 14-1 | 0.47 | First |
| 11-1 | 14-2 | 0.51 | First |
| 11-2 | 14-1 | 0.25 | Second |
| 11-2 | 14-2 | 0.31 | Second |
| 12-1 | 12-2 | 0.47 | First |
| 13-1 | 13-2 | 0.51 | First |
| 14-1 | 14-2 | 0.57 | First |
| 15-1 | 15-2 | 0.44 | First |
| 16-1 | 16-2 | 0.48 | First |
| 17-1 | 17-2 | 0.48 | First |
| 18-1 | 18-2 | 0.5 | First |
| 19-1 | 19-2 | 0.34 | First |
| 20-1 | 20-2 | 0.41 | First |
7-3-2: DNBSEQ-T7으로 생산된 48개체 및 Nova-Seq으로 생산된 2개체에 대한 친족관계 분석
그 다음으로, DNBSEQ-T7으로부터 생산된 48개체 데이터와 Nova-Seq으로 생산된 2개체의 데이터를 이용하여 IBS 테스트에 의한 IBS 점수를 계산하였다. 482개의 SNP 마커를 이용한 50개체 IBS 테스트에 의한 IBS 점수를 비교 매트릭스로 도 16에 나타내었다.
아래 표 16 내지 표 19에는 각각 First-d-r, Second-d-r 및 Third-d-r 관계에 있는 두 개체 사이의 IBS 점수를 나타내었고, 도 17에는 First-d-r, Second-d-r, Third-d-r 및 나머지(other) 그룹별 평균 IBS 점수를 나타내었다. 그 결과, First-d-r의 평균 IBS 점수는 0.509 (0.378 내지 0.667)이었고, Second-d-r의 평균 IBS 점수는 0.280 (0.087 내지 0.414)이었으며, 그리고 Third-d-r의 평균 IBS 점수는 0.139 (-0.096 내지 0.270)이었다. 마지막으로 서로 관련이 없는 개체(Unrelated, other) 사이에서 평균 IBS 점수는 0.020 (-0.335 내지 0.285)이었다.
본 발명자들은 First-d-r의 IBS 점수가 위치한 버퍼 영역인 0.378 내지 0.667와 Second-d-r의 IBS 점수가 위치한 버퍼 영역인 0.087 내지 0.414가 서로 일부 겹치나, 총 50명의 한국인 가족관계에 상술한 실시예 2-2에 따른 482개의 SNP 패널을 이용하는 경우, 본인을 기준으로 First-d-r 관계인 개체, First-d-r 관계에 있을 가능성이 있는 개체, 또는 First-d-r 관계에 있을 가능성이 높은 개체를 남으로부터, 즉 First-d-r 관계가 아닌 개체, First-d-r 관계에 있을 가능성이 없는 개체, 또는 First-d-r 관계에 있을 가능성이 낮은 개체로부터 구분할 수 있는 정보를 얻는 데에 유용함을 확인하였다.
| Degree | 샘플 1 | 샘플 2 | IBS | 샘플 1 | 샘플 2 | IBS |
| First degree relative | NFS_202100101 | NFS_202100103 | 0.494 | NFS_202100121 | NFS_202100120 | 0.523 |
| NFS_202100101 | NFS_202100107 | 0.518 | NFS_202100203 | NFS_202100201 | 0.516 | |
| NFS_202100101 | NFS_202100112 | 0.541 | NFS_202100203 | NFS_202100202 | 0.495 | |
| NFS_202100101 | NFS_202100116 | 0.491 | NFS_202100204 | NFS_202100203 | 0.493 | |
| NFS_202100102 | NFS_202100103 | 0.514 | NFS_202100204 | NFS_202100201 | 0.46 | |
| NFS_202100102 | NFS_202100107 | 0.536 | NFS_202100204 | NFS_202100202 | 0.522 | |
| NFS_202100102 | NFS_202100112 | 0.494 | NFS_202100205 | NFS_202100207 | 0.573 | |
| NFS_202100102 | NFS_202100116 | 0.426 | NFS_202100205 | NFS_202100202 | 0.526 | |
| NFS_202100103 | NFS_202100105 | 0.532 | NFS_202100206 | NFS_202100207 | 0.449 | |
| NFS_202100103 | NFS_202100106 | 0.459 | NFS_202100207 | NFS_202100209 | 0.509 | |
| NFS_202100103 | NFS_202100107 | 0.552 | NFS_202100208 | NFS_202100209 | 0.53 | |
| NFS_202100103 | NFS_202100112 | 0.667 | NFS_202100301 | NFS_202100304 | 0.499 | |
| NFS_202100103 | NFS_202100116 | 0.421 | NFS_202100301 | NFS_202100305 | 0.525 | |
| NFS_202100104 | NFS_202100105 | 0.457 | NFS_202100301 | NFS_202100303 | 0.461 | |
| NFS_202100104 | NFS_202100106 | 0.465 | NFS_202100302 | NFS_202100303 | 0.496 | |
| NFS_202100105 | NFS_202100106 | 0.509 | NFS_202100302 | NFS_202100307 | 0.592 | |
| NFS_202100107 | NFS_202100109 | 0.503 | NFS_202100304 | NFS_202100305 | 0.54 | |
| NFS_202100107 | NFS_202100110 | 0.525 | NFS_202100304 | NFS_202100302 | 0.535 | |
| NFS_202100107 | NFS_202100111 | 0.561 | NFS_202100304 | NFS_202100303 | 0.464 | |
| NFS_202100107 | NFS_202100112 | 0.476 | NFS_202100305 | NFS_202100302 | 0.523 | |
| NFS_202100107 | NFS_202100116 | 0.592 | NFS_202100305 | NFS_202100303 | 0.472 | |
| NFS_202100108 | NFS_202100109 | 0.497 | NFS_202100306 | NFS_202100310 | 0.482 | |
| NFS_202100108 | NFS_202100110 | 0.508 | NFS_202100308 | NFS_202100306 | 0.462 | |
| NFS_202100108 | NFS_202100111 | 0.537 | NFS_202100308 | NFS_202100310 | 0.437 | |
| NFS_202100109 | NFS_202100110 | 0.398 | NFS_202100308 | NFS_202100307 | 0.437 | |
| NFS_202100109 | NFS_202100111 | 0.443 | NFS_202100309 | NFS_202100312 | 0.573 | |
| NFS_202100110 | NFS_202100111 | 0.513 | NFS_202100310 | NFS_202100307 | 0.526 | |
| NFS_202100112 | NFS_202100114 | 0.551 | NFS_202100311 | NFS_202100309 | 0.59 | |
| NFS_202100112 | NFS_202100115 | 0.522 | NFS_202100311 | NFS_202100312 | 0.554 | |
| NFS_202100112 | NFS_202100116 | 0.44 | NFS_202100311 | NFS_202100310 | 0.496 | |
| NFS_202100113 | NFS_202100114 | 0.516 | NFS_202100312 | NFS_202100310 | 0.538 | |
| NFS_202100113 | NFS_202100115 | 0.513 | NFS_202100401 | NFS_202100403 | 0.479 | |
| NFS_202100114 | NFS_202100115 | 0.571 | NFS_202100401 | NFS_202100404 | 0.551 | |
| NFS_202100118 | NFS_202100117 | 0.513 | NFS_202100402 | NFS_202100403 | 0.545 | |
| NFS_202100118 | NFS_202100116 | 0.506 | NFS_202100402 | NFS_202100404 | 0.525 | |
| NFS_202100119 | NFS_202100121 | 0.495 | NFS_202100403 | NFS_202100404 | 0.378 | |
| NFS_202100119 | NFS_202100101 | 0.49 | NFS_202100405 | NFS_202100401 | 0.619 | |
| NFS_202100119 | NFS_202100102 | 0.519 | NFS_202100405 | NFS_202100407 | 0.494 | |
| NFS_202100119 | NFS_202100103 | 0.556 | NFS_202100405 | NFS_202100408 | 0.495 | |
| NFS_202100119 | NFS_202100107 | 0.563 | NFS_202100406 | NFS_202100407 | 0.469 | |
| NFS_202100119 | NFS_202100112 | 0.572 | NFS_202100406 | NFS_202100408 | 0.443 | |
| NFS_202100119 | NFS_202100116 | 0.526 | NFS_202100407 | NFS_202100408 | 0.453 |
| 차수 | 샘플 1 | 샘플 2 | IBS | 샘플 1 | 샘플 2 | IBS |
| Second degree relative | NFS_202100204 | NFS_202100205 | 0.385 | NFS_202100207 | NFS_202100202 | 0.292 |
| NFS_202100203 | NFS_202100205 | 0.356 | NFS_202100101 | NFS_202100105 | 0.278 | |
| NFS_202100205 | NFS_202100209 | 0.33 | NFS_202100101 | NFS_202100106 | 0.211 | |
| NFS_202100405 | NFS_202100403 | 0.237 | NFS_202100101 | NFS_202100109 | 0.148 | |
| NFS_202100405 | NFS_202100404 | 0.284 | NFS_202100101 | NFS_202100110 | 0.156 | |
| NFS_202100118 | NFS_202100119 | 0.302 | NFS_202100101 | NFS_202100111 | 0.202 | |
| NFS_202100118 | NFS_202100101 | 0.216 | NFS_202100101 | NFS_202100114 | 0.313 | |
| NFS_202100118 | NFS_202100102 | 0.36 | NFS_202100101 | NFS_202100115 | 0.333 | |
| NFS_202100118 | NFS_202100103 | 0.274 | NFS_202100102 | NFS_202100105 | 0.347 | |
| NFS_202100118 | NFS_202100107 | 0.393 | NFS_202100102 | NFS_202100106 | 0.183 | |
| NFS_202100118 | NFS_202100112 | 0.291 | NFS_202100102 | NFS_202100109 | 0.113 | |
| NFS_202100311 | NFS_202100308 | 0.167 | NFS_202100102 | NFS_202100110 | 0.178 | |
| NFS_202100311 | NFS_202100306 | 0.342 | NFS_202100102 | NFS_202100111 | 0.274 | |
| NFS_202100311 | NFS_202100307 | 0.256 | NFS_202100102 | NFS_202100114 | 0.273 | |
| NFS_202100304 | NFS_202100307 | 0.3 | NFS_202100102 | NFS_202100115 | 0.239 | |
| NFS_202100308 | NFS_202100312 | 0.248 | NFS_202100103 | NFS_202100109 | 0.144 | |
| NFS_202100308 | NFS_202100302 | 0.216 | NFS_202100103 | NFS_202100110 | 0.242 | |
| NFS_202100312 | NFS_202100306 | 0.372 | NFS_202100103 | NFS_202100111 | 0.295 | |
| NFS_202100312 | NFS_202100307 | 0.266 | NFS_202100103 | NFS_202100114 | 0.397 | |
| NFS_202100401 | NFS_202100407 | 0.294 | NFS_202100103 | NFS_202100115 | 0.355 | |
| NFS_202100401 | NFS_202100408 | 0.341 | NFS_202100105 | NFS_202100107 | 0.394 | |
| NFS_202100305 | NFS_202100307 | 0.414 | NFS_202100105 | NFS_202100112 | 0.384 | |
| NFS_202100310 | NFS_202100302 | 0.301 | NFS_202100105 | NFS_202100116 | 0.284 | |
| NFS_202100119 | NFS_202100105 | 0.356 | NFS_202100106 | NFS_202100107 | 0.297 | |
| NFS_202100119 | NFS_202100106 | 0.305 | NFS_202100106 | NFS_202100112 | 0.327 | |
| NFS_202100119 | NFS_202100109 | 0.169 | NFS_202100106 | NFS_202100116 | 0.231 | |
| NFS_202100119 | NFS_202100110 | 0.215 | NFS_202100107 | NFS_202100114 | 0.355 | |
| NFS_202100119 | NFS_202100111 | 0.351 | NFS_202100107 | NFS_202100115 | 0.376 | |
| NFS_202100119 | NFS_202100114 | 0.303 | NFS_202100109 | NFS_202100112 | 0.087 | |
| NFS_202100119 | NFS_202100115 | 0.363 | NFS_202100109 | NFS_202100116 | 0.23 | |
| NFS_202100121 | NFS_202100101 | 0.232 | NFS_202100110 | NFS_202100112 | 0.121 | |
| NFS_202100121 | NFS_202100102 | 0.29 | NFS_202100110 | NFS_202100116 | 0.245 | |
| NFS_202100121 | NFS_202100103 | 0.334 | NFS_202100111 | NFS_202100112 | 0.177 | |
| NFS_202100121 | NFS_202100107 | 0.376 | NFS_202100111 | NFS_202100116 | 0.292 | |
| NFS_202100121 | NFS_202100112 | 0.343 | NFS_202100114 | NFS_202100116 | 0.308 | |
| NFS_202100121 | NFS_202100116 | 0.273 | NFS_202100115 | NFS_202100116 | 0.286 | |
| NFS_202100206 | NFS_202100209 | 0.185 | NFS_202100303 | NFS_202100307 | 0.296 |
| 차수 | 샘플 1 | 샘플 2 | IBS | 샘플 1 | 샘플 2 | IBS |
| Third degree relative | NFS_202100204 | NFS_202100207 | 0.199 | NFS_202100121 | NFS_202100106 | 0.076 |
| NFS_202100203 | NFS_202100207 | 0.257 | NFS_202100121 | NFS_202100109 | 0.044 | |
| NFS_202100118 | NFS_202100121 | 0.227 | NFS_202100121 | NFS_202100110 | 0.03 | |
| NFS_202100118 | NFS_202100105 | 0.169 | NFS_202100121 | NFS_202100111 | 0.136 | |
| NFS_202100118 | NFS_202100106 | 0.11 | NFS_202100121 | NFS_202100114 | 0.226 | |
| NFS_202100118 | NFS_202100109 | 0.153 | NFS_202100121 | NFS_202100115 | 0.269 | |
| NFS_202100118 | NFS_202100110 | 0.154 | NFS_202100209 | NFS_202100202 | 0.092 | |
| NFS_202100118 | NFS_202100111 | 0.202 | NFS_202100105 | NFS_202100109 | 0.044 | |
| NFS_202100118 | NFS_202100114 | 0.236 | NFS_202100105 | NFS_202100110 | 0.149 | |
| NFS_202100118 | NFS_202100115 | 0.226 | NFS_202100105 | NFS_202100111 | 0.2 | |
| NFS_202100311 | NFS_202100302 | 0.169 | NFS_202100105 | NFS_202100114 | 0.27 | |
| NFS_202100304 | NFS_202100308 | 0.104 | NFS_202100105 | NFS_202100115 | 0.231 | |
| NFS_202100304 | NFS_202100310 | 0.19 | NFS_202100106 | NFS_202100109 | -0.096 | |
| NFS_202100308 | NFS_202100305 | 0.114 | NFS_202100106 | NFS_202100110 | 0.096 | |
| NFS_202100308 | NFS_202100303 | 0.063 | NFS_202100106 | NFS_202100111 | 0.124 | |
| NFS_202100312 | NFS_202100302 | 0.155 | NFS_202100106 | NFS_202100114 | 0.179 | |
| NFS_202100403 | NFS_202100407 | 0.054 | NFS_202100106 | NFS_202100115 | 0.205 | |
| NFS_202100403 | NFS_202100408 | 0.039 | NFS_202100109 | NFS_202100114 | 0.043 | |
| NFS_202100404 | NFS_202100407 | 0.01 | NFS_202100109 | NFS_202100115 | 0.019 | |
| NFS_202100404 | NFS_202100408 | 0.062 | NFS_202100110 | NFS_202100114 | 0.125 | |
| NFS_202100305 | NFS_202100310 | 0.179 | NFS_202100110 | NFS_202100115 | 0.071 | |
| NFS_202100310 | NFS_202100303 | 0.221 | NFS_202100111 | NFS_202100114 | 0.151 | |
| NFS_202100121 | NFS_202100105 | 0.232 | NFS_202100111 | NFS_202100115 | 0.163 | |
| NFS_202100204 | NFS_202100207 | 0.199 | NFS_202100121 | NFS_202100106 | 0.076 |
결론
서로 관련이 없는 88명의 한국인 SNP로부터 발굴한 본 발명에 따른 918개 및 482개 SNP 패널을 이용하는 경우, 한국인 촌수 기준 1촌 내지 4촌의 친족 관계에 있는 한국인 집단에서 두 개체 사이의 각 SNP에서 각 염기 종류를 쌍으로(pairwise) 비교하는 IBS 테스트를 통해 평균IBS 점수를 산출하고, 산출된 평균 IBS 점수로부터 본인을 기준으로 First-d-r와 First-d-r가 아닌 개체를 명확하게 구별할 수 있음을 확인하였다.
아래 표 19에 요약한 바와 같이, 상업적으로 이용 가능한 시퀀싱 플랫폼인 Nova-Seq으로 생산된 40개체의 WGS 데이터에 대하여 본 발명의 실시예 2-1에 따른 918개의 SNP 패널을 사용하였을 때 First-d-r의 평균 IBS 점수는 0.501로 나타났으며, Second-d-r의 평균 IBS 점수는 0.226으로 확인되었다. 마커 세트, 즉 패널을 달리하여, 본 발명의 실시예 2-2에 따른 482개의 SNP 패널을 사용하였을 때에는 First-d-r의 평균 IBS 점수는 0.496이었으며, Second-d-r의 평균 IBS 점수는 0.233으로 확인되었다.
| Nova-Seq으로 생산된 40개체 | 918개의 SNP 패널 | 482개의 SNP 패널 |
| First degree relative의 IBS 테스트에 의한 근연도 평균 값 (버퍼 영역) |
0.501 (0.382 내지 0.574) |
0.496 (0.340 내지 0.620) |
| Second degree relative의 IBS 테스트에 의한 근연도 평균 값 (버퍼 영역) |
0.226 (0.166 내지 0.299) |
0.233 (0.175 내지 0.309) |
| Unrelated의 IBS 테스트에 의한 근연도 평균 값 (버퍼 영역) |
-0.014 (-0.193 내지 0.144) |
-0.02 (-0.277 내지 0.175) |
또한, 아래 표 20에 요약한 바와 같이, 상업적으로 이용 가능한 시퀀싱 플랫폼인 DNBSEQ-T7으로 생산된 48개체의 WGS 데이터와 Nova-Seq으로 생산된 2개체의 WGS 데이터에 대하여 실시예 2-1에 따른 918개의 SNP 패널을 사용하였을 때 First-d-r의 평균 IBS점수는 0.508로 나타났으며, Second-d-r의 평균 IBS 점수는 0.253으로 확인되었다. 마커 세트, 즉 패널을 달리하여, 본 발명의 실시예 2-2에 따른 482개의 SNP 패널을 사용하였을 때에는 First-d-r의 평균 IBS 점수는 0.509이었으며, Second-d-r의 평균 IBS 점수는 0.280으로 확인되었다.
| DNBSEQ-T7으로 생산된 48개체 및 Nova-Seq으로 생산된 2개체 | 918개의 SNP 패널 | 482개의 SNP 패널 |
| First degree relative의 IBS 테스트에 의한 근연도 평균 값 (버퍼 영역) |
0.508 (0.413 내지 0.635) |
0.509 (0.378 내지 0.667) |
| Second degree relative의 IBS 테스트에 의한 근연도 평균 값 (버퍼 영역) |
0.253 (0.087 내지 0.378) |
0.280 (0.087 내지 0.414) |
| Third degree relative의 IBS 테스트에 의한 근연도 평균 값 (버퍼 영역) |
0.136 (-0.024 내지 0.273) |
0.139 (-0.096 내지 0.270) |
| Unrelated의 IBS 테스트에 의한 근연도 평균 값 (버퍼 영역) |
0.025 (-0.187 내지 0.263) |
0.020 (-0.335 내지 0.285) |
보다 중요하게는, 본 발명에 따른 918개 SNP 마커를 이용하는 경우, 종래 방법보다 적은 수의 SNP를 확인하여도, 심지어는 부모의 정보가 없는 경우에도, first degree relative 관계에 있는 두 개체의 평균 IBS 점수와 second degree relative 관계에 있는 두 개체의 평균 IBS 점수가 위치하는 버퍼 영역이 확연히 구분되므로, 즉 두 버퍼 영역이 서로 겹치지 않고 구별되므로, 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 하나인 first-d-r 관계인 개체와 first-d-r 관계가 아닌 개체를 명확하게 구별할 수 있다.
또한, 본 발명에 따른 482개 SNP 마커를 이용하는 경우, first-d-r 관계에 있는 두 개체의 평균 IBS 점수와 second-d-r 관계에 있는 두 개체의 평균 IBS 점수가 위치하는 두 버퍼 영역이 서로 일부 겹치므로, 본인을 기준으로 first-d-r 관계인 개체와 second-d-r 관계인 개체를 구별하기에는 다소 제한적이나, 본인을 기준으로 first-d-r 관계에 있는 개체와 first-d-r 관계에 있지 않은 개체를 구별하는 데에는 유용하게 사용될 수 있다. 법과학 분야에서 두 개체가 가족관계라는 가능성을 배제할 수 없다는 증거는 유의한 의미를 가지며, 482개만의 최소한의 SNP를 서로 비교함으로써 남으로부터 first-d-r 관계에 있는 개체, 남으로부터 first-d-r 관계에 있을 가능성이 있는 개체, 또는 남으로부터 first-d-r 관계에 있을 가능성이 높은 개체를 구별할 수 있어 비용면에서 경제적이고, 친족관계 확인을 위한 시간을 단축시킬 수 있으므로, 본 발명에 따른 482개 SNP 마커는 법과학, 법의학, 또는 과학수사 분야에서 실용적이다.
결론적으로 본 발명에서 선별된 친족 관계 예측을 위한 두 가지의 SNP 패널은 First-d-r과 관련이 없는 개체(unrelated)와의 구별에 유용한 것으로 보인다. 918개 SNP 패널은 First-d-r와 Second-d-r를 서로 구별할 수 있을 것으로 기대된다. 그러나, 482개 SNP 패널은 First-d-r와 Second-d-r의 구별은 어려우며, 두 가지 패널 모두 Third-d-r를 관련이 없는 개체로부터 구별하는 데에는 적용이 어려울 것으로 판단되고, 이러한 제한점은 918개 SNP 마커 전체 및 482개 SNP 마커 전체를 동시에 사용하거나, 918개 SNP 마커 전체에 482개 SNP 마커 일부를 동시에 사용하거나, 또는 482개 SNP 마커 전체에 918개 SNP 마커 일부를 동시에 사용하는 등의 SNP 마커 수 증가를 통해 해결할 수 있을 것으로 판단된다.
본 발명에 개시된 SNP 마커 전체 또는 그 일부를 한국인 친족관계 확인을 위해 사용하는 경우 First-d-r인 개체를 First-d-r가 아닌 개체로부터 명확하게 구별할 수 있음을 당업자라면 이해할 것이다.
따라서, 본 발명은 한국인의 유전적 특징을 파악하여 만든 적어도 두 가지의 SNP 패널을 제공하며, 918개의 SNP 및/또는 482개의 SNP 패널을 비교하여 모집단 내의 유전적 거리를 측정(measure)하고 예측(estimate)할 수 있으므로, 법과학수사에 유용하게 적용될 수 있을 것으로 기대된다.
또한, 본 발명에 따른 SNP 패널은 많은 개체수의 원시 데이터를 한꺼번에 처리할 수 있으므로, 대형 재난이나 오랜 시간이 지나 대조 가능한 직계가 사망하여 현재 기법으로는 감정이 불가하고, 유가족의 유전적 거리가 먼 경우에도 예측이 가능하므로, 과거사 해결에 도움될 것으로 기대된다.
참고문헌
Anderson, C. A., Pettersson, F. H., Clarke, G. M., Cardon, L. R., Morris, A. P., & Zondervan, K. T. (2010). Data quality control in genetic case-control association studies. Nature protocols, 5(9), 1564-1573.
Andrews, S. (2010). FastQC: a quality control tool for high throughput sequence data. Cambridge, UK: Babraham Institute.
Fan H, Chu JY. (2007). A brief review of short tandem repeat mutation. Genomics Proteomics Bioinformatics. Feb;5(1):7-14.
Li, H. (2013). Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. arXiv preprint arXiv:1303.3997.
Ward, L. D., & Kellis, M. (2016). HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease. Nucleic acids research, 44(D1), D877-D881.
Pedersen, B. S., Bhetariya, P. J., Brown, J., Kravitz, S. N., Marth, G., Jensen, R. L., ... & Quinlan, A. R. (2020). Somalier: rapid relatedness estimation for cancer and germline studies using efficient genome sketches. Genome medicine, 12(1), 1-9.
<110> Republic of Korea(National Forensic Service Director Ministry of Interior and Safety)
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gattttaccc acattatgat cagtgaaatc atagatgttg ncatgcctta gaaattaatg 120
ggacatgccc aattaataaa agcaggatgg aacatttaag aagaggctaa gaactggcac 180
tctatctaca ctctaggtaa a 201
<210> 27
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 27
ataaatgaat ggatctcttt ttttatgtaa aacccaaata attaagaaag aaacaaaata 60
aacatggtat gttgttttat tttcttagtt ttagcaattc ntatttttct ttatacctta 120
attctgtgaa tgggagtaaa tgggcactgt tgcttcccaa atactcataa ggataaaata 180
aatacagcaa agatagtcaa a 201
<210> 28
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 28
agataaattg gagtggagat aactcaaaaa ggaaattgta ctcatgagag aaagcatata 60
taaaacaaca ttgaagcctt taaagcacta tagaaactaa nttttgttgt gattctaata 120
taaaataatt ttactaatct ttaaatttaa atttatctta gtccagtgtt tcagccttgg 180
cactatcaac aatttgggtc t 201
<210> 29
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 29
agttctttat tgcttgatgt ctaaatgtct aacatctccc aaagcattgt ttttgtaaca 60
tgtctggatt ttgctgtagt tattgtttca gactgattta ncaactatta agcctaactt 120
taaattcata attttattta attatttcta actatgtctg gtgaccctaa ttatcaaagg 180
aattccaagt ttctgctggt g 201
<210> 30
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 30
atattagaga gagaaggcaa aaacagaaca gaacaaaaca aaacgcacct attgagctct 60
ggttcaaaga atgtcatgca tgctgaagga gaacatctcc ncatctgaga aatttacttt 120
gctagttagt aatgtaaatg agtcttaagc tattgcatca atgtaccatg gaggctagat 180
tctcatgaga agaaacacta a 201
<210> 31
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 31
aaaaggcatt ttatagaata atacattaaa atatataaat ataatataca tgtatacaat 60
ccttatataa actattatga tcccttaact ttactgtaga ncacatagct gaggcaatta 120
gaatgaaatg aggtataagt attggaaaaa gggcaaaatt gcatactttc aaatttcatt 180
atatattagt aaatttggag g 201
<210> 32
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 32
agatgtggtc tcactatgtt gcccaggctg gacttgaact cccggcctcc aagggatcct 60
cttatctcag ccttttagta gctagaatta cagatgcaga naatttaccc atcagtatgg 120
aggctcccct actgtggtac catcatattt tagatttctc gtccattctc cattgcctta 180
gatcattaaa actgcatcct t 201
<210> 33
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 33
acaccatttt agagccacca tatcagccct agattattta tctcgtaact ttatgtcaaa 60
agtgaaaaag aagcctaagt ttaattaagt cactataatc naatcaaact gctggtgccc 120
actcacagtg agcagtttca ttctctgagg aattcaggct ctttccgtca ttctagccca 180
cattttagtc actgacatgt t 201
<210> 34
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 34
aattatacag tcaggagaca atggggaata tttttgaagt gctggggaaa acaaacaaac 60
aaatggtttt ccaacagttg ttctcttttt ccccactgcc ngatgtgctt tgcttagcct 120
caaagaggtt ttctatagga agaagttttt attaacattc tggtgttatt acttacctta 180
tgaaattata gaaacatcgt a 201
<210> 35
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 35
ttaacaatcc tagatacttt taggtttatc atagactcac agaagtttaa acctagacag 60
ctaaataggt tcttatatat tgtctcctat aaccacatac nacacatgga gatagagatg 120
ttcaaagggg ctttgtaaga ctgctgggtg acaggactac aatctgggtc tcaattacca 180
gttctttggc catcctatta g 201
<210> 36
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 36
tgaagttttc agtccagatt tgtagtgagt gttaaattta ataatttttg aaagagtgag 60
aaattgcagc aaaaggagca agataattat ctggaaacat naaacaatct gtgtttctta 120
cttttgttat gcaatgtaag tactcttgga aatgcaatct gaggatactg taacaatttt 180
taaaataaga aaggaggata g 201
<210> 37
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 37
gcgccaggcc agtttttttt acctcctaaa atatacctgg gctttatata tataggtgat 60
atttatatgt aactatgtat tactacagta agatatttgt ncaattgact attttcataa 120
aagttttaga taatcagaaa ttgatcatat aatgcaataa cagtaaatat attccctcca 180
cacctccgtc ccccccgcac c 201
<210> 38
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 38
aacagaagga ggggggcgga ggcctgtgtt tacagatgag atttaactgc tgtaccaggc 60
gtggagactg agaccccgca accctgtggc gcctcagtcc ntcaataaca gtattgagtg 120
gtcaggttac aataaaccag agaggaaagg tccgcttgca cttttttttt tttttttaga 180
cacccctccc atccagggtg a 201
<210> 39
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 39
gatttgccag acattacaag ataagtaagt gtcaaaacga agaatcaaac agaaactcag 60
ctagcattcc tggactttct aacttctgga tcatacttac ntgtgtttta tgaacaatta 120
accctattta aggatatctt cattaaacaa ctgcaaggta ttcttcctgt aatttttttt 180
aaatgtggtt ttcaaaagaa t 201
<210> 40
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 40
aaacagaaaa tcagaggtga gtatattgca gtggatgtcg taagtcagca aagatgagcc 60
cattatcaca attgtgcgct agatttgatt tatggtttaa ngacactaca atgtgtacac 120
cttaaatcca aaaatggtac agcattcctt cttacatccc caccaccact accatttctt 180
gcactgaata tatctgaatt a 201
<210> 41
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 41
cagaatggta aagtttagtt tgtattatcc agtgttccaa gccttttcat tagccttaga 60
ttaaactcaa acttctgtgg aaagatacac tccagagaca ncctagtgat ataactttcc 120
aaaatctata agtgttggat aaattcattc atttatccaa cagctatttt tcaatgccta 180
ctatcaatct agtactgctc t 201
<210> 42
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 42
tctgtctttc atagaatttt atacccagat actttagtta cattgtaaag aacctccccc 60
atcctcatca tatgcaacat tttttacaaa taatttgtct ntccgcttcg cctgaactaa 120
aatattggat ctcttctgag atcactcttt cttctatgtc atctatagaa ggttgctaat 180
tttcctgtag cccatggccc t 201
<210> 43
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 43
agatttaccc agtgccagga agagcccacc tgtttgtatg gctggctgta actgaatgct 60
cagtgaggtc tgttttcttg ggataactct gtagaaacca nacaatacct cagcgttgca 120
aacgggagct cttcacagat gctttttgtt ctcctgtcac tgattttcag atgaatatgc 180
aaataataac aactataaag t 201
<210> 44
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 44
attttcattt gcactgaagt caacttagag gcttgtctct ctggatttat atcctctgtc 60
ttttattttt ccctttttct tcagtgtttt acctggttgt ncttcctctt tattttttcc 120
tttatctaat catttcttac agaaatagcc ttactaccaa tggcatcctt aaattagcta 180
ctatatatga aaatatttaa c 201
<210> 45
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 45
acacacacac acacacacac acacacacac acacacacac acacagacac acacctggtt 60
cagatgttta gaatcattag gagaaggaag catcattgga nattaacctc taatttctac 120
agcaggcaga gaatattgtt acagctgtaa ccctatggat aggactatga aaaaaacttg 180
agaacccaac tcaggaatta t 201
<210> 46
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 46
tagcttgata tggctgtcaa tgccagggga aaaggacatt cgcttctggt ttgtggtcct 60
ctcttccttt gtgttccttt ttttatgttc acttaaaaac ngtcttccaa ttgtaaaagt 120
tcttaccatc tacttaacaa tattttggcc tatgaaggta attttgaaaa catttgacat 180
agcccatata caatttttga a 201
<210> 47
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 47
aggcatcaca tactctaaaa gaaggagaag ccccaagtaa ctgatgaaag tgtgtggccc 60
agggtctgtc acgctcagct gctcagtgat catttctgtc ngttttctcg aagtggtgga 120
atatgctggt gcctcttgtc agggaagggg catcacccaa ggctgcaggc caggaagaaa 180
aagaatcaga actctgggtg g 201
<210> 48
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 48
tctgtctttc atagaatttt atacccagat actttagtta cattgtaaag aacctccccc 60
atcctcatca tatgcaacat tttttacaaa taatttgtct ntccgcttcg cctgaactaa 120
aatattggat ctcttctgag atcactcttt cttctatgtc atctatagaa ggttgctaat 180
tttcctgtag cccatggccc t 201
<210> 49
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 49
gaagatagaa gtgggaatag tgaaagataa agagacacat agagggaagg cagctaatgc 60
ttttatttga agatatgcag ttcccttcta catgtaagtc ncttctctga aaatttcatt 120
tctgttctgt tttcattgct gaaactcttt taagcaatgc cttacttgtg agctagcccc 180
aacatatctc ctgcacatat t 201
<210> 50
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 50
tcagatctta gtgcttgtca gctaaaagta aaccatagtt tagcttcacc taatttccca 60
ataagcgttg cagtatatca tgaaacagaa atgaaattaa ntgctcagga atttctcatg 120
caccaaccgc aggctgcagc aggtgctcct cccctcccag cctgcctctg gagagttccc 180
ttgtggaggt tgttatgact t 201
<210> 51
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 51
gtgaaggagc atccagcccc accctgtcca taacgggaga ttggcgtgct tcccttcgca 60
ggggtggaga gagctgcacc ccttaatccc tggaatggga ngacataaga gtcaagaaga 120
acgtcaatat cgttaaagga aaaggaaata taaatttcga attcatcttc tgacggaaat 180
gaaggcagtt ttctaagttt c 201
<210> 52
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 52
gaagactctg aaaatgttgt gttcattcct tgagattggc ggaatgccca tttaacaagt 60
ggttttttct ccccctctct ctttgagaag attctgcctc ntgacctgat tagattagtg 120
catttggaaa caaagcttat tcaggtctgg taatttagaa aaaaaaaata atagaatagc 180
taaactctaa tagtataaaa t 201
<210> 53
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 53
agtgagatga gcttttgcat ttactgacag tatcaagtaa atctgtaaag ctgaaaattt 60
tgagaaattt tgaatatgac caaagataat tgtagaaaaa ntgtcaaccc catacatgat 120
tctagcacta agcttagcaa acataaattt taaactttct tccaaactgg aaaatatatg 180
gttaagaggt ttttacattc a 201
<210> 54
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 54
atcgcatgaa cataataact tcaagacaat caagacaagg tgctgatctt ctgtggatgc 60
ctccctggga ggtgagtatt ctgaagacta aagcccacac nggtgaaact gattttggta 120
tgaggtgagg cagggcacac agtggattca gatctttaaa agcagacagt gcagaactgg 180
tatgacttca gtttggtaga a 201
<210> 55
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 55
ggtccttcct cctccccacc ttctcttttc ttttattaaa acctctggag aatgacatgg 60
ttgccatgta aatgttcagg aagtggcttc catcctagcc ncgtgaatgc cataggatct 120
ctggaggaga gggaagagtc agatagaagt cttgaagcca tctggggaga aagaaaggct 180
taccttccca aatttcagcc c 201
<210> 56
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 56
tccacctttt tctcttttca agttgaaaca cagctctgaa atctgtggga gtggcatgga 60
atttggggat gtgggttttc acccttgctg tgaatggaga nagattcttc ctgtactaac 120
tcccacttct cctcagactc ttcttcctga catttcttcc tcctccaccc agaaagctat 180
ggtggttcct caagggtcac t 201
<210> 57
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 57
gtttttagaa atgcatgtat gctcaccatg tgccacagaa cttgagagca acaggagccg 60
gtcttctgtt ttcaacaact tgtcatgaat gagccacaaa ntcggtaaat catgggtgta 120
taattcacat atacctttgt ctgtcttttc ctaactggca ttcgttgagg gatttggagt 180
tgtctctaaa acatgcgact g 201
<210> 58
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 58
attggaagtc agaagtttaa agaaagcggg ttttctttaa ttcaactgca gttaactcac 60
aggaaactgt ccttccatgc taataaatgc ttttgtctct ntgatgccca aaaagtcaac 120
aatggattca gcacagtcaa taaaaatagt caaacttgtt attgactagg tataaagcaa 180
acaacttaat tggctcattg t 201
<210> 59
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 59
gattgtgcac atgctaaagg gaggggcggg agcagcagtg cgggagatgg catgtcacac 60
acagtcataa taatcgagct acatctagcc agataacgct ntctttgctt acaaatctag 120
gaaataagcc agaaacttac caaagaatag gagtgattac tgatactgac taactaaaaa 180
aatgtctcct tcctcttcgt t 201
<210> 60
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 60
ccctcgtgct gcagtgagct gtgaagttgc agagttctca ggcacaccca ctttccctgg 60
tgtaggcccc tgtaaatgtt actattacca gtaacgacta ncccttcaga gttgggggac 120
tttcagacat ggtatctcac ctgagcccca cctcacggcc ttccagccag tgcaaaccaa 180
caacctcctc cattctcaca t 201
<210> 61
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 61
gtagaaggct tcacagttct gttaaagtgg ccctcactga ggtgttgtgc taggaagaaa 60
agaccttggg cataacaaag ccacatccca gacagcctgc ngcacactcc tgttgccaga 120
gctggtgact cactatgact atccttgtgg tttctgctgg gcagctgggc tgggccattt 180
aatgttcatc attaattact g 201
<210> 62
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 62
tttccctcta tttttcatgt ctttatgtga ttaattatga gaaaattttt ttatatcttt 60
cttgagattt ataatttttt cttccatggt gtttgattta ntgatgaaac tttttattaa 120
gttttgttaa atttcaaaaa attaattttt atttttagtt tatattttta aactgtattc 180
attactttga tagtatttta c 201
<210> 63
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 63
attccaaggt tgtgcataat taaatgatgg caaatgggtt ctgaattatt gtttagtaac 60
aactaaaaaa gtgaaaacat aaagttggaa taaacatgaa ntaaatgctg gatccaaaag 120
ttggagaatg ggcctggcga ggtggctcac gcctgtaatc tcagcacgtc gggaggccga 180
ggcgggcagc acgaggtcag g 201
<210> 64
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 64
tggcccacta agtcagtgtg taatgtggaa caagtaaaag cttaggttaa gcaagtgaaa 60
gtgtgaggtc aatgaagaaa cagcctgttt ctgtctcatt ngtaacttat ctaaagaaac 120
aagcaaattt tcctgagaga tcccaggtaa tcaataaata aacataacta aaagaacaaa 180
taagtaaaat aaaaaatgtt a 201
<210> 65
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 65
aacagctact ggcagaagaa gttcttatgt gactatatta taaaatacat actgcttttt 60
aattggcaac aagtcctttg ctgtgacctg ttggaaaaaa ncactctata tgggaagggg 120
aacaaaatta tcaggaaaaa catttaatct caggaaataa cacattcaaa aacgtttact 180
taaataaatt atgtaactat t 201
<210> 66
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 66
gatgttagga tgatggcaaa gctaaatgtg atgtatttat atagtgagga tacctcttaa 60
aatttataat gtgtcagtca gtacactgga tgccttatat nttgtaattc atttagatgt 120
tttactaccc cagtgataaa tttcatcctc atagaggtta tctgtcaaag tcacacagtc 180
attacctgga aaaatctgag a 201
<210> 67
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 67
ctggggattt gtagcacatg tgttacaaac acttcttgcc tcttgcccaa aacacagtac 60
aaatccaaag tgtgccttat atcactcatt catgcagcca ntaactacat tattgatttt 120
tttgactcaa aagacatgca actattaatg ttcatctacc aattataatc aaagaaagaa 180
atgtcaggaa ggatagagaa g 201
<210> 68
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 68
gttaatcctt atgtttaatg cttccattca tcaaggagtt aggttaggct tgagaaaagc 60
atgtctaaaa gaaagagctt tttagccatc agtaagaaca nctttgaaga tcctgaatca 120
ctgtacaaga gggactcctg gacaccaaac tttcattcct cctgttttac atattttatt 180
cttataaatg aaacaacatc a 201
<210> 69
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 69
attggtccat catttcttat tcctgtgtgt ccttgagcaa tttgagcacc agggttactt 60
gagctctgga aaaagaatgg aatgatatcc cacagctgga nagaaggttc agcggcgcct 120
gcagtgactt tctcctctgg ctcctcggct gtccttctcg tgagtggctc tcttggttgc 180
tctagagctc cttcttcctc c 201
<210> 70
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 70
atcaaaattg aaaccaatct agcacaactg agcaagtttc ataggataga taggaattga 60
catagatctt ggtgaaaaat gatttcaata tgaaaaaata naaatgtgtc tataataaca 120
cagaaaggat ttaagatatt taaaatagag aaaaggaact gagcactaac tcttccaagg 180
cactgagatg caattcgcaa t 201
<210> 71
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 71
taaaccttgc ctacaaccct tgaagctgtg caaaatttga ctaatgagac agctaaatgg 60
gcaccaggac cttgtaagtc ctccgctgcc aaatgatgtg naattactgg ctctaggagc 120
ataagcttcc tcagaacctt gaagaaaggc tgcctgtgct ccaggaggca gagaagcagg 180
atgaacgtgt gcttttaacc a 201
<210> 72
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 72
ctctagggtc agctgaatct gggtgaaatt gtaacttttg caatttgata tttcagtggt 60
ttggactaga gccagacagg ttatttttcc aaataggcca ngtccaggta gttcctgata 120
ttttaagcat catgatgaga gtgtcaagta atatgttaca tcctagactt aaaaatctca 180
ataactgcag agcagatgtg a 201
<210> 73
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 73
tgggaatgga agtctggttg caggaagttg agagttgaat gagatgctgt gcagactgag 60
ttaggccaca ctttgtagaa gttctagtga aaagagaaga ngaatcttac tagagggaac 120
acaacaccag ggttttattc ttggggtggg ggaggaggaa aataacatac ctatttatag 180
aatgagtaca gaagcttggt g 201
<210> 74
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 74
aagtgcagag agagcacaca ggctgtgcag tgatgttctg gagtcggaac tgaggccagg 60
gagaggcaga agtgagagtt tcattataga caattgggct nagaagaccc tgaataaatc 120
ttattttaca tcactttgca ggcacacttt acattgttgg ctctgcactt cacagcctca 180
aaatgggatt cgatccaggg a 201
<210> 75
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 75
tggaattttg aggctgaccc atgcttttca tcactttcag tccgccttcc ttaaaattgg 60
aggcaacaga aggaggagtc aattttcagc acaatcatac nctgaccaca tggcctcctg 120
gctcccatct ctaccttttc cactgggggt tcaactcctc agtgtggtag ttcattaagg 180
gggtagcaca gtgcctgaca c 201
<210> 76
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 76
atcagtattg cctagttcca taaaggaaat actaatagtg ggaaatctat gtaggtactc 60
acaagccatc gaataggaat ttgtaaaaat gtggacccac nttctggtga tactccttga 120
tccctcagat tggtgattgg gtggttttca taacccacaa agaacttcat gttcaaccaa 180
aagaggtgcc tgcttttctg g 201
<210> 77
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 77
accccaatca gggcatcagc tgtgccacca tcttgtgata ctttagttaa ttggttgacc 60
attctttttc cccaaaatga attgcctcta ataagcaaga ngggctgaag gcagttttta 120
aactatcaaa aagtgatttt cagtcactat aagtgttttg ctttagaatt taagaaaccc 180
ttccctgctg gcattaatat a 201
<210> 78
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 78
gccgaagtag aattgcgtat taagccagtg tctccatcca ggtaagaaag aaagtgggtt 60
ccatccttgc ttcccctgag tagcatgaga ccagtctcta ncatggtgta aagtcccaca 120
gcactaggac cagcgattcc actccatcag cattcaattc atctcttcac cagcttcatt 180
aatgctcccc tgctagggtg t 201
<210> 79
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 79
ataagactga agactgttgg cgctgtagca tgtgctttct ggagttactt aggttcctga 60
catctgtctg taggggagcc agcagcaccc tgtggcgctc nggctctgaa gagttgctga 120
cctcagggcc tttgattaga gaggtccttg caaagggaag atgtccactc tgcttggact 180
acctagctaa aatacttcat a 201
<210> 80
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 80
actgatacat atacttcaac aaatacacat gcacagttat gtgtacaccc acaaagaaac 60
attcacccat gcagagagac acacactcac ccacccataa ngacacatat agccacacca 120
aacatgcaca cgcagacact tgtgtgcaca ctgatacata catttcccca gtcatgctca 180
cacacatagg cacaggttca t 201
<210> 81
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 81
tacacggtat tccgcaccat attccacacg gtattttgca caatattcca catggtattt 60
gacgaggtat gcccactgac tctgcacagg tcttgaatat ngtagtggcc tggattatcc 120
tgcagtgatc attcactccc gttcctccac ccccgctcag gcccatgcac tttcctgccc 180
catttatatt gggcttggcc a 201
<210> 82
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 82
caagatgaga tttgggtggg gacacagagc caaaccacat cacctaatat tgctgaatgt 60
gggcaatata gaaatgtttg gtagctttag gccaggttta nacaagttgt atcaaagccc 120
agttgccaag tctctgacgg ccaggtggtg tttgcacaca cggaaagatt tggcaggcaa 180
acagcacaag acacgttgaa c 201
<210> 83
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 83
ctctctgatg ggggcctgca ggcagcaaaa gccattagga gcaatttgtt gtcaccaggc 60
aggcctgctc cccctaaact gttatcaatg agcttgtcaa ngcaaggcct aaccgccttt 120
gttcttttca tctgtttttc cctcagaggc ctctccggac cctatggcct tctcagagga 180
gctgcaacag gctgttgtac a 201
<210> 84
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 84
ccatgctctg ttgcctgggt ctctagtttg tgacctgatg tctgtcactg aggcatctcc 60
tggggtttcc ccttctgaga agggggctgt tggcaccatc naacaaaagg caatgtgatc 120
tttcagaggc cctggtgcac gaagctggcc ctcctgcctt catgccatct ttaggtgtgt 180
ccagcctgaa tatgtagctt a 201
<210> 85
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 85
cacagggcct ggtactggac acaaaggaag aaactgaaaa agtacttatt ctagagaaag 60
cattcagact gtgggcccac ttgcttcaat gacaggcaag natgaagtcc tccattgcgt 120
gtcgtgattc ctaacctcaa agaaaggttg acttttggag ctcaatgtta aaggctaagt 180
agatttgaga atccagatgg g 201
<210> 86
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 86
ggctgtgtgc caataaaact ttatttacaa agacagaggg ccagattcga tgtgcacact 60
gtcatttgct aactcctgat ttagtacgtt attcctacta ntaccacccc cacctcctag 120
ataccagttt ggaaactgtt ttgccagggg ccctgggcta gtcttggtca gcataaatcc 180
tgctgcctgg ggcattttaa c 201
<210> 87
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 87
tatttacaaa gacagagggc cagattcgat gtgcacactg tcatttgcta actcctgatt 60
tagtacgtta ttcctactag taccaccccc acctcctaga naccagtttg gaaactgttt 120
tgccaggggc cctgggctag tcttggtcag cataaatcct gctgcctggg gcattttaac 180
tgttcgcaga gatcaaggtc c 201
<210> 88
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 88
gttcatgacc aagggttaag ttgctcattt tgacaaaaga gggaagccat tgtatgtgtg 60
gctggtgggg tgggggcaca cacctgcacc tgctatccag naaccccaga ctgatggatt 120
tttattttgg aagcattgca tcaaccagga gagaagacca cttgggggag tgggaccctg 180
agccgaggtg atccttggcc a 201
<210> 89
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 89
ctctcagcac cgtcctccca gctgggatat ctcagtgtcc ctgtcttcca agaccaggtg 60
gtggaaacgg gaaattgcgt tgcattgatt attttcagcg naagagtttg caatttccat 120
ctagcatggg aaacattttt ttcatgctct ttaaggaaaa gacaagattt atgacagatc 180
agaattatta ttattattat t 201
<210> 90
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 90
ttgatgaact tgattcctct gcttccgcct gagaggcctg gagccaggat tgagagaacc 60
agctgagaaa ggcagaatca accagtagga gcaaatggca ngattttgtt gttggaccgg 120
gagggaggaa gcagaaagag aagaggcaag agtggaggct caaaccatag tttgggaggc 180
ctgggtctga gctgtgagaa t 201
<210> 91
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 91
cccactcacg gccttctgct cctggtgaaa ttagcaacag aagatgcaag aggagggagg 60
caaagggctc tcccaagagg gggagaatta ttgcaaagga ngaaggaaca ggctgaacag 120
acccagggaa caagccagca catgagcgtg tgccactgga gatggtcctg ataggggaga 180
agggggcagg atgtacaagt c 201
<210> 92
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 92
tcacaatcca cccagtgccc acactgatcc ccatgtggaa gctggggacc cagcattagg 60
tgacctccat tgatggcatc atgtgtatgg aggtgacatg ntgccttatt ggtctccagg 120
gtcctgggct ctctggctga ctcttgagcc acctattgag ccaaattcag ggtaagccag 180
ttctatagaa tagaatcttc c 201
<210> 93
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 93
tcttgtcctc tggttccagt tactcatggt actcctccaa ccccatgagg cctggctcgt 60
gtattaataa ctattgtaga aaagtgtcca agtctcttac nttctctggt ttctgtttta 120
gagatgatac aaggaaatat aacactctgg atcacttcat cttacccaaa gcaagaacat 180
cttaaaggat ttagatactg a 201
<210> 94
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 94
gagaaggagg cctatgcgga gaggaaatct atatgtgtgg gccaagggat ggccagggtg 60
ctaatgtcag cattgcactt ctaggactaa gctttggttc nctgacagga tggaggagct 120
gaaactaaca cttatagatt caggctgaga ctctggggcc aggctaaaat ttgtccaagt 180
cagtggtggt tcatggttcc c 201
<210> 95
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 95
tgccgggctg cgtgcagagc atcatactta ggatcaaatt attgccccca aagagtcgtt 60
tttcttcacc cctggtggca tgcttcttgg aagcggggag ngaaggggtt cctgcagtga 120
ctaacaaaat agattatgga gacagccact tatcttattt gtcatctcgc caaagaaagg 180
ctgctctgat gttccaaaaa a 201
<210> 96
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 96
actcacggag tccaactgta taactatgag attaaattag ccatttatgg atttcagaaa 60
gaaaggagac taaaatgttt tatagtgtag ttaaaaaaaa ncattgaatg agtccctcat 120
gttgaacatt tcctcatgtc agaagcaggg tggatgacac agaaaccata aatccaattg 180
ataagtgtta aaatcacttt a 201
<210> 97
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 97
ccagcaatga taaccagtta gctcacgaac aaaggaagaa cagtggctcc ttacccctgt 60
gccggtgcat acagactcta tgggcaacca cattctcctg naatccctac ttcactttcc 120
ttctttttca ctagactctg agccaactgc cagttgtatt atggtttcag agcccagcac 180
agagcatgtc acccaaataa t 201
<210> 98
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 98
gctttgctgc tttgctctgt gggagccgcg aagggaaggc tccagggcct gagtgaaggg 60
tgcggaatgg cccatgaggg gtcccatggg gagtccacaa ngggtgctcc ggccaggctc 120
ctgtaggagg cagggtctgg gctgagcagg tttcaggaga gggaggggag tgtgaacagc 180
aggtcccact tagagctttc t 201
<210> 99
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 99
cgttctctcc tgggttgctt ttcgtagact tgcaagagaa acaacaggtg ctcttagtct 60
cctttggatc cagaaagtca ccagaaggat ctcctctata nggtcgcaaa ggactcagga 120
caaggcagat gcattttaaa aatactcccg acagtgaggc cagggaggga gtggggtgca 180
ggtgggggct ggtgactgtg a 201
<210> 100
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 100
tcccaaaagt ttataagtgt aataaatgtc tagtgaaatc tttgactttg taagcaatga 60
taaatttaca gataagtgac agcccctgca gaggcaaagc nctgctgtga atccccagat 120
aactgtcatt tatttatgtt tctaaatgtt caagtaaaag cctgcatttt caacagcatc 180
tgtaatgacc tcagagcttc a 201
<210> 101
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 101
gctactaatg gtgaagtgca aagcagctgt gcatgcacag aaaggggcat gaagaggcag 60
cctccacagt gtgaataaac acacctgtgt tcaaagacca ngccctgaca gcgcccggca 120
ggtgcaatgc aagtctttct ctgatattca ttcacggtct tggaatagtt tttgttgtgc 180
ataattttaa tagcatacat t 201
<210> 102
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 102
attccaggta aaggcgcatg cgaagaccct gagaccagag gaagaagcca cgaccagcag 60
caacctcagg accagggcgg agggaagccc caggggaaat naggcagaag aaaggcagga 120
aattcattta tgtggaagaa gaagctaagg ggtgctagtg gaccaggaag aaggaaagca 180
tcatccaacc acagagaatc a 201
<210> 103
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 103
ttctaattat tggctatgcg atattggaca tgttagtaga accctatgaa ttccagtttt 60
atcatttgaa agttaagcat ttcttgagta actttatatg ncaatatcct gaagtagcac 120
acagtatagc tcttcacagg ttagtagaaa ggtctttgtt aaaaggctct taccctaacc 180
attgctttgt tacaaacgga t 201
<210> 104
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 104
ttactttctc tgggtgaagt aacagggcag tgaaaccaac atgagagtgc aaactctcag 60
aagacaattt taccacccat atatctattg attcatttag nctttattaa ataaatattt 120
actgaatgac tactatgtac aaagaactgt gctaagtgat aggaatcagc aggtgacaaa 180
acagaagaaa cacctgtctg c 201
<210> 105
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 105
cactagacgt agaattctaa aatggctgtc taaaatttta ttactattta caaccaatat 60
actatttatt ttgcattttc taagtcctga atgaactatc nttaattatt tttaggtagt 120
taatttttcc attaaaacat aagtggtgtt ttagaacctc tatgggaaaa ttattactaa 180
actacaatgc actagttcca a 201
<210> 106
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 106
agccatttaa caaaaatatt ttacaggttt agaaaatgtt tgggaaaggc cactaacaaa 60
actatcacgg agcataagca tatttgtaaa caaagctaac ntttgatttt gaatatgcca 120
aatttaactt ttaaagagaa atgttgactt ttcacttctg ttcactacag ctttcattat 180
caatgcattt ttctacccgc t 201
<210> 107
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 107
gattttctga ataaccgtat gtaataccaa gagtcactat aattagaatt ctgcaatgta 60
acacagtgga agaaatgatg aattacccat ttcaaatctg ntatcccatt gccatttcat 120
caaatacata gatgaataat tagtcatcat aaattcactt cagagtattt attgagcacc 180
tatttggtgc ttgggtctgt g 201
<210> 108
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 108
aacacattca ttaagtatgt tttaaagctt ttggaagtga cccagaacca agtgggtatg 60
gtcaaaagga agtagtcaca aaggaaaaaa gaatatctca natttattga ggcactcact 120
gaggacgtgg taaagctata tattacagat ctgatgtggt tgttctggta ggaacgaggt 180
ctgaggcatt ctcccatagt t 201
<210> 109
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 109
ttttgtggga ggtgacagag atgtgcaaca gcaggtatgg aaacttctag gactgaggtg 60
agaggcaagt gggtgggatg aaaccaaagg agtcatagag ntgtgtttgt aaagctaaaa 120
agtagggtcc gaagagtttc ttcaaggaga aagaatctgc aactggtggc ctgccacaag 180
ctaagtaggg atgcaggggc t 201
<210> 110
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 110
ataaattatc ttgattggca taaacacaca ttcactctcc acttctgaga aggagaaggc 60
tgagaagaag cttcttccct tattagtggc tgaatggaaa ngaactgatt ttatagaatt 120
agaattctgc ctgtagggaa catggagaga tagagaaaat agatttgtgt gtttgtattg 180
ggggttttgg cctacttggt a 201
<210> 111
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 111
aaagcatctc tatgggtaac aggaccatta gactaagttc aagcaataga atctccagcc 60
tgactctaaa acctctagca tgattcttct gctttttcta ngcttatcag ccagttagag 120
gcaaatgatc cagaatcaat gtcagacgta caagaagaaa gaaccatgct tttctgaatg 180
agtcagtgtt aacagtccag a 201
<210> 112
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 112
tgtcatttgt aattaaaatg agggctttgg ctgttgtttg aggataaaaa tgcagcaccc 60
atcttttcaa aataacttaa ttatggagat catatggggg nttaactgag ttttgaggac 120
attcttttag agaataaaat gacaagaatg aaatattgca gatgtacaga tagtaaaaaa 180
aaaaaatcca tggaaacaaa t 201
<210> 113
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 113
aagacaaaat gggggaaaaa tgtggaagga agattgggga aagaggaggc aaatgcagag 60
ggcaagacag taagggaaca ttctccttgt tacacaatac ncagaacctg ccacagtttt 120
aaagtatcta gatagaagga ctctgtcctg gaaagtcttg ccttcccctt ggggttggga 180
tttctaatgc tcccaaggtg a 201
<210> 114
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 114
acaaatcact atgttagttg aggtctgaaa aattgtctgt attagccaaa tgtcaataaa 60
ccaaactaaa atgacaaaaa tttccagaca tatacacaag naagttctgg tgataatgca 120
atggaagcta taaatatcag ataaatccta aagatctctt attcatgagt tttcaggtat 180
tctattgcca caggtcatta a 201
<210> 115
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 115
cctaattgtg ccaccccaga tccccaggac aggggatcag cacctctatt cctgttcttc 60
agcatcatgt atttaattat tttgtgttta tttgttctgc ntgaaggacc gggcaaaaca 120
atttgtactc ccagaaaaac ttaaaagtac agaagttttc taatcaggtc tcacatggat 180
gctatgaaaa caacagaagc t 201
<210> 116
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 116
gctggtctca aattcctggc ctcaagtaat ttgcccacct gggcctcctg aagtgctgtg 60
attacaggtg tgagccacca cgccctgcca gtgaagactt nttgagagga atggacatcc 120
tttctacttc ccagggcgtc ccctgagacc cagaggccca tgttttaagg aaataaagac 180
ataagtctgg tggactctat t 201
<210> 117
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 117
cgagttttaa tctgttcaga attattctta aacagcactg cctaatccta aaagtgtcaa 60
aatcctcctt gcaaggtgat attggtacag cagagaaagg ntgacaaatg acaaaatgaa 120
catatgattt cgaagtatta gtatataaat tccagacatc tgcttggaga aaaatcaatt 180
agtgctcatt aagcatttaa a 201
<210> 118
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 118
attgttgttg ttttattcct gctcttaaaa accttggaag tatcagaatg agctgtctag 60
gatgaaagtt aaatttccca gccctagaga gaatcatgct ngctctttca atgcatttca 120
tgagtcctag aaaaattgct actattattt acaattttcg attttttttc cactggtaag 180
atattgagtt agctggcaga a 201
<210> 119
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 119
tctattatat ttatatatag attaatattt aacttttccc tagcttataa cattaaaatt 60
tactgtaatc tttaaatgtt tctactaatt tctcatatca ntgcgatgta tatcctgaca 120
tctatgtcac tgaatctgaa ttttactaac tcccaaaaat tattgccatc tatttttgta 180
tttaagacct ctaaatgtaa t 201
<210> 120
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 120
cctatctcaa cttctcagct ctttcttaga gcattcatta gccaaataac catgttgcta 60
cttgacagac tttagattgc agcttcatgg aagcctgaaa ngtctcaggg acaggccaaa 120
ccagagagca agtgttacac aatcgctcca gctaaatcgg acagtcttct ctttccacca 180
tgtgatggtt aatactgagt g 201
<210> 121
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 121
ctctctggct ctcaaactcc tgttcataat cactgcactc tactgcctct cactgcactc 60
tgcctaacag agacaccaca tactgactgg gcacaacagt nggagtctta gggggtttaa 120
atggattcat ttctttagaa actctttatc aaggaccata gtaggcactg gggatagaga 180
aataaatcag gcagaaaagt c 201
<210> 122
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 122
ctcgccccca ataccacttg gaagagaagg atttctgcaa gagagaagat cctgtttatt 60
cgagcagaaa tgtgccgtag ggtccagctg ctgtcttgta nagttgtgga cgtctaacca 120
aatccttctt ggggccttca gcttctttca gctcatccac tcatcgcaaa gatgggaagt 180
gattcccctc actccttccc c 201
<210> 123
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 123
tagcacagag aagatgctgc cctctctccc aaggccacct gttcttcctc cctgtgcagt 60
gcctgcctcc gtccccactg agcatccagt gatgcccttt nctaagaacc tgggatgggt 120
gagtcagaag gggcagctgg tatctggtct ttgactcacc ggaagcatcc ctgacctgct 180
gaatggaaaa gtctcagctt a 201
<210> 124
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 124
aaaatgtgcc ccttcttgct ctccagctgg ctctgcccag atatcttcaa ggagacctga 60
aatgaccagc tgaaggctat ggttcagaaa tgagtcagcc ngggtggtgg tggccctagt 120
gggaaagctg acagcataag tgcaggaatg gcagcaggca gtggagctgg caagacataa 180
ggtggggctg ctgagcagag c 201
<210> 125
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 125
tttctctcat tccaagcccc taattgcctc taggcattca gagaagcagc cctggctcca 60
ccttacttga agaatcagca catgaacaaa atcagggctt nctgcttttt cattctggga 120
catgactgga aaagtggagt ggaggtttcc cttcccttct aaaaatatgt gcgcatacac 180
tggcacactc acatgcatca c 201
<210> 126
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 126
aaaagggttg atattattct gcctgccaaa atgagtctaa acgtgtaact catagcctgc 60
acaagtcaca cctccagtac actagtttgc aagtccttat ngtcttcatt cattcatgcg 120
ggagtctggg ctttaggaac cagccttggt ctgggagtcg ttttcccgcc tcccctacaa 180
tgtttatttt atttaatgga t 201
<210> 127
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 127
tttgatcttt agatccagcc attagatgtc cagttcagga caaaacgtgg gtaacagagc 60
aaggaaaaag atcccctttt cacctctgct accaagctca nagaggttgc tatcagatag 120
gatttgaatg aaaaatcatg tgatggtcct gggtttagtt aggcttttac tgactccatt 180
catcccgcaa caccccgtga c 201
<210> 128
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 128
gtttattaaa atgtgagaaa agtttcttga ctgctttcat ttaagtattg aaaatatatg 60
ataattatcc aatgcttcaa tattttaaga cattaaatct ncagtatgtt gatgattaag 120
tatatggcct ctggtattta tattttcagg tgaagagcag aattgcatct aaatcagggt 180
gaaaagtcct ttccagcaat a 201
<210> 129
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 129
tccatagtta agtaccccag agctaggctg aaatccagtg ttggattgtt tccaacttat 60
agtagggaac cgccaatgac atgaaagagc attaccttac nggactgatt catattctac 120
ttccagtcat agtacaaatg atcacatgtc cacacccaca tgtgctctga taagtagtca 180
attgagagga gtgagtcagg g 201
<210> 130
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 130
acaggccttt ctacatgctg gatttcatat cttgttaagc agatgtattg atccaatttt 60
tgtggtcagc tcaatggtac aggaactaga agaacgtgct ngaaagcata ttaaacacaa 120
gagcctcctc cagaaatggt gatgcctttc atagtaatct aaggggtaag aaaggaaaag 180
gatggataag taagctcact c 201
<210> 131
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 131
tctcagcttc aggctcacac caagtctccc ataagaagcc aatctgctca tgatctctct 60
tcatgatggg attgctattt cttcatttta taatattaca ngaccctcta atttaaaagt 120
tgctcccatc tatagggcct catgtcattg gattcagaca gaagctttgt aaaagaattt 180
tcagtgtctc tagtttacag t 201
<210> 132
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 132
aaggaatgca gagttcaagc tcttctttca ccatttgtaa tttactgagc cagctactta 60
acttttcttg ccttgattca atttctgaag agactaaaaa ngtttttcct aactaaatga 120
tgtgagctga acagatgtct ttctgtccca gtttttatgg caaactcatt tttccgcaat 180
tttttattgc caattttagt a 201
<210> 133
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 133
ataatgacaa tttttagaat aattattcat tctgatggga taaaagcatt tataggctaa 60
aaataaaaac caattttatt gccttaccaa tattagttta ntaaatttca aattttaaaa 120
gagaaccctt taaagttttt tatttttgtt tctgaagctt taaactcaaa atacatttta 180
gagaacactt tattgttact t 201
<210> 134
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 134
gagtggctga aggaaaagga ataagttagg agtcatagaa ataatctcta atccactgag 60
aattttaatc ttttaaatta aagcattaga aaacttaaag ncttaatata cacaactccg 120
gtaatttaag gtgctcttta tttgtaccta gtaccatttc cttaatcaca actagtaaaa 180
ttagcaggca agggcactgt t 201
<210> 135
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 135
cagaccctgc agagaggtgc tcataaaata tgttttgaat aatgaatatc actcatatag 60
gtttattgag tgtttacaag attcccagcc tgggttaagc nttttgcagc ttgtgtttaa 120
aatataaata cctttcagtc aaaatttatt ttatgtggtg ctacagcaga tatatacctt 180
gctttagaaa ataaataaat t 201
<210> 136
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 136
aacttctatt tcttccaaac tacataaact ctgcacttcc tttcctagga caaatacaat 60
atgagagggt atagtgctgg cgttgttgca ggcccactca ntagcccaat aaaacgtgcc 120
ctaattttca gctaattttg tttcttttgc aatgttcttc aatggagcat tttaaggttt 180
ttccctctta taatctggca t 201
<210> 137
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 137
ttaggtcaac aagtagatgc aaaacaaagg catatcttga tcagctttta catttatcat 60
atataaaaca ttaaaataga gaaaacttct agcacagagc ngcaattcat gttgttggtc 120
aagctggata ctgcatagtg gtgtcacttg cattgaccat tctgtgaatg gtggtccctg 180
gagctacata ttgtggtggc c 201
<210> 138
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 138
atactgtatt actcaccatt aaaaatattt taatgttctt gtgcagttat aaggtaactg 60
tatactaagt gtagaagcat gtggattcac atttctatca nagacatttt gtgaacctaa 120
ttaatttggg aatctattag ctttacccta gggtaattaa ttatgcaaac aagaaggtac 180
acagaaacac tggtatcact a 201
<210> 139
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 139
caatgctatt gcaacaatgc ctgaaaaaga gtaacatgga aaatgtccaa tggtcttcag 60
ctgttgttgt tgctactggg attcatctct atgtggtttt natctaaatt agtgtttcct 120
aaataatata gagataatga aactcaaaga tgtgatcaga cttattaact tccaaccttg 180
gcaagaaagt aaagtcatgt c 201
<210> 140
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 140
ggaacttttt agcagcagaa tcccatgctc ttatggcaat taatatgttg tccatgatgt 60
tgtgcatggc ccagtattga agtaactttt tatgaagaaa nagtttgctc tgctcatttg 120
acccacagag tagaaaggaa taggaggggg agtgagaaaa agggaatatg agataaacca 180
aaaatacatt cggaacaaaa a 201
<210> 141
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 141
tcctttcagt gcttcctatg gaccaaacca acatgggaat caaggagcac agaagtctga 60
gaaacacaat ttgtagtgaa ggagtgagga aaagatctga nggcaaaatg acaaataggc 120
tcatacccta aatctaacaa agaaacacat ggaaactgca cgtttatgca tgactactga 180
gcgagaacaa gataattgaa t 201
<210> 142
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 142
gtaatgaatt ttcattaaga aaacatatta actcttgctt ggcatagttc ttccctggta 60
ggattgcagc aaatcagagc tttttatggg tggtcttttg nggggagaat caaacccaat 120
aaaatatttg gatacttttc cagagagaaa aaaaataaat ctcaagatgt atgatattca 180
tctactgtgt tatatggcag t 201
<210> 143
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 143
tcggcttaga tacttaggat tcacattcaa gaatgatact gatggaatca aacaaaaagg 60
ggccagtact ttctgagcta attgtttaga actagatttt ngctccagct gcaataaatt 120
ggaagatgga tgatgtgagc atttgtaatt tgtaatttaa aacttcgcga accatgaaac 180
tttctggaga ctttggtcag t 201
<210> 144
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 144
aacctaattc ctagacccat ttgactttaa atctattaat catgtgttca tttatttaaa 60
gtaacctgga ctatataaga ggctaaagat gaagggatat naaatatgga ttttaaagat 120
aacaatcatc gtctcagtct atctaaatgg gcttctataa ttcccaaact aattataata 180
ttgaatactt ctttccttat t 201
<210> 145
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 145
tttttatctt atactcaagt atttcctcct caatgagttt aatattgctt tctatgccta 60
aaacctccta aatacctgtc attcacctta atgattccag ntcattcttt atgtatcatc 120
tgtatgtact tttttttcag ggaagtcaat ctgagcatac cttcacccta ctctatcctc 180
atctcactac agcctgtgtc t 201
<210> 146
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 146
ctcattagaa agttgccatt ggtcaataac gtttgtggag ctcactaaag gaaggagaat 60
tataacggaa caatgtgaac catccacttt atcatgatgg natacttata tctaagtaga 120
gtatatcaga gttaatcctt tcatctgttc acttgagtag aaaacagtat tttccaaaat 180
atttcttagc atttattttc a 201
<210> 147
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 147
gaaaatctca taattcccat tctacccaca ttcatttgtg cccctaccaa actatgtggt 60
gattgtccac atacagacta gactttttga aatgatgcta nagcctgcca tattctctgt 120
ttcatggaat cagatgtaaa tttaactttc aacctgtatt acatgttcaa atgaatttgg 180
atttggaggt tttatttaac a 201
<210> 148
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 148
actttgtacc ctgagatacc ttgctgtaga atctgctgtc ttgatacttt tcttctgaag 60
atccctggtt tggatggaga tcattaccat cttagattta nagtccgatt atcttattat 120
ttttaagtcc tgcctgtaaa atgggctaat aaatgtatat gtcacagggg gaatttaaga 180
attaaatatg ataatgtgga a 201
<210> 149
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 149
caccagctta aagaggaaat ggagagtgtg tttgcgtgtt ttctgccatg aaataggcat 60
cctgagacaa tctcttcata actgatgtag cccagccctc ngtactgaaa ttgctggact 120
cacacgaggc ccagatgtgg tttaaagagc atgtggggga aatttccgta ggagcaacac 180
agatctctct attcagagtt t 201
<210> 150
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 150
cttcccccat ttctccactt tctcagctcc ttcctttccc aaggagtttg caataagaag 60
acctgttaag tttcaaaatc acccaattta ccctctggtc nttattggaa gcttttcttc 120
atttccaact agaagcacag atcttctgta gatacaggta ctgtttgagc ttccagacac 180
ttcacagttc acaagcagtg g 201
<210> 151
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 151
gatgggagtt tctgagcaga ggtggcatgc ccatggtacc ctcctgctta tgtggttacc 60
tgtgtcccaa ggtgggtcag cctgtgttca ggatctcaca nagtctctca tgaaaatagt 120
tgtgggcttc agactcattc tttgctccca aatcaaagtt taacacaaat catgggctct 180
tgtgtggctc tggcatggtt c 201
<210> 152
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 152
aaatatcatc ctaccattct ctgacttaaa aggctgcact aactttgcat tttcctggag 60
ttaaatctca tctcagactg tggcttatga tgtcttgctt nttctcctaa acttgcctca 120
gcttaccctt tcattcccat actctatcct ctatcctcac tacactgatc tttgcagagt 180
cttgaccaac gtttcctgac t 201
<210> 153
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 153
acttctcata atttggattt agaaataatt aatcatgaca aactaggaaa aaagttgata 60
tttaactctc acaggtcctc aatgcagtgt aatctacaca nctttgagaa gaaatgtcta 120
gtcatggact gtccttgctt gcaagattga tttagcgaag gctgtaaaat ttctcccaat 180
aaggccaata aagatataaa a 201
<210> 154
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 154
ctcagcctcc caaagtgctg ggattacagg agtgagccac tgcatccagc aagttcaaaa 60
tatatttctg atcaatgata aactagaata aacttgagtg nacagatagg tatttgaata 120
aaaagattct ggctatacgt cttttaaata atacatttat ggttatgtta attcacagga 180
cctggtttta ttagggaact a 201
<210> 155
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 155
atcccctaaa ttgatgcagc tcaacattac attaatgata agtggataat ttactgtaga 60
tttggcgggg aactggagtg tgagtgaggc caaccttgca ntgttcccat tctgcatctc 120
ttcctccttc ctgttaggta actgatggct ccttacaaat ctcctctact gaatagagca 180
gtaaaactct catttctaag t 201
<210> 156
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 156
tgtacatgtg caggtcacag gggatatgat ggcttagctt gggctcagag gcctgacaaa 60
cccctctgac tattgactgc tttcctttct agaaaccctt naccctttac tatatcgtgt 120
acctctatcc ctgggctgga cttctggtcc attccctgga ctcctgttcc tctgcctgac 180
acttcaaatg ttggtgcttg t 201
<210> 157
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 157
caatcaggtt ttctcaggtg ataggcatgt tattgtaaag atactcagga aagcaagaaa 60
gcacaggaaa ttggctcagt cagttgcaaa gtcagaatag nggaaaatca tttttgctca 120
ggctacagtc aaaattctaa ataccccaac aaaaattcta gctattggct gtgttttgat 180
tcaccttacc tcttctccaa c 201
<210> 158
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 158
gagcttctta agtatatgca tggggttaaa aaaaacaaaa gcagacaggg cacataacaa 60
aaacacgtct ttgacatttc tattgcagga aataaaggag nagtgcttca gtcagccaac 120
ttttaaaagg tgaaacccag gtcatcagtg aaagtaaaac agcaatgcct caaataagaa 180
aatatacccc ttaataaact g 201
<210> 159
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 159
ggacctctat tatttcccac aaaagaaggt tacatgagat tactccaagc atctgaagtt 60
ctaaaataaa aatactgttt ttcttaatgg atcaatgcag nattaaatgc ctgtgttttg 120
cataagtgaa tgataaacaa tagtgcttgc actttcctaa agttttagag ggcttcttag 180
aaatagtatc tgccaaatct a 201
<210> 160
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 160
tgtatacatt caataaataa tgcaaaaaac actatttgag cttgaagtga ataaataatg 60
ttgggtttga gttattttgg taaatttcaa gtgatttttg nttggtggtt tgtcagcatg 120
tttttagttg agttaatatt cccagaggac tacagcagct taaggaggaa tgaattaaaa 180
agaaaacata ttattctagg a 201
<210> 161
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 161
tattgaatat taggaccttt ttatattttg tgtgcacatt ttacactaga gccttctcat 60
acactctaat gaaagatgga ctgcaaaatt ataattgatt ngttagtagg ttggtgaacc 120
tccagcataa atctctatct ttctctctct ccgtctctct ctctctctct ctctctctct 180
ctctctctct ctctctctat a 201
<210> 162
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 162
ctagagactg tctttttgtt ggccctatat tccgttggtt ttcatatctg ttctacctta 60
gtttctatct acattttaca tgcatgttcc cttttgcccc ngagtttgag gaatctggat 120
tctcttcttc ttctgtgtca tggcttttaa taccccatca tcaagtactt tatgtacaac 180
tagcctttga gacactcaat a 201
<210> 163
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 163
cattccctgc ttcaagttgt aattttctga acaaataact ttaaatgtca ttgtccctgt 60
attctatact actacagcaa gtttgaggat gtgctagttc naaatacata tagagggtac 120
attaaaattg gttttcattt atatgcattt aaataatatt aaagtactgc ttaatttggg 180
tgaagtaaat tattctctca t 201
<210> 164
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 164
ttgttatcga tgtaacaact gtgtgaatga caatgtttaa gtgctaaaat atttgcaaaa 60
gggaatcgga atctgctgtt tcttccaagt cattaaagca nagccggata gttgaaacaa 120
aacagaatca tgcgtagttg gcaaactgaa cagaaaataa catccacaca gcatgccctt 180
ctgccatgta ctgtgctcat t 201
<210> 165
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 165
gtacaaaggg gcaatgactg tattagaaat gaaaggaaga attaaaccta tattgaagtg 60
aatggggaaa actggagcat aaataaaata ctgagaaatt ncagttaact cagttgtact 120
tcctaccaag gtggggatat tactcccaga gcagcacatc aagaaaagct tgaacttcag 180
acttgacctt ttcatcttca a 201
<210> 166
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 166
ataaattaaa gtttaaaaag ttcattgaag agcattaact aggagtaggt acttggaaag 60
tactatcagt agtcagtcac actggagaaa aagtgtgcaa nagtagtacc agagcagtaa 120
gtgctgagca tgtgtgtggg ctctgtactt acacaataaa acatgcacat acaaattttt 180
cctactaaaa tgatgacaaa a 201
<210> 167
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 167
tgagcaaatc tcagacacca taccaaagca atgggtagta atagccagta attggttaga 60
atttggcaca tctctccacg tcttatttct cggagaccaa ncatatcata ttttttagat 120
aaatggaagg aaaaaaaaaa agaaaatctt gcccctttct tattttcgtc gaagaagtca 180
cgtgacagcc ttggtttcct t 201
<210> 168
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 168
attgatgata gtaatattgt cttacctctg ctaatgtttt aaagtttgat gacatgttgt 60
gcaaccttct ttccagtaca tttgatctca tttgacattt ntcacggttc caaacttgaa 120
ggaactaaaa ctaagaggtt agtggacttg cctaaggtcc cccaatccat ttagtttggg 180
acttagtatt aaatctatac t 201
<210> 169
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 169
gccatgatca tcctgtcctg ctttcatcta aggcatgcag ccggtctggc tctgattaga 60
tgccctgaca gtagacactc ttctcctcac gatgaaatac nggcatattt agcttagaga 120
atcagtgaga gaaatgtagt taccatactt ttctttctgg ttggataaac tttactctca 180
ttccaaaaga gaaatcgtca g 201
<210> 170
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 170
tcatctccaa tctccatgta atcacctatc atcacttcgg acataaaaca tctgcaacct 60
tagataaagg taaccacatg aacattggca tagatgaaat ngaaaagcca aaggaattga 120
cggaaataga aatatacagg tgtttctctg agggcacctc aaatggtact aagagggtgt 180
atagtccact aatttaagag a 201
<210> 171
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 171
gagaagtagt actacatgat tccacttata tgaagtatca aaagtagcca tactcacaga 60
aatagggctt tcttttttaa tgaaagataa gtggaagata ntctagaaga aaagttgtat 120
aataggttta ctgatgaagc acaaccctgt gatagaaaaa gcataaaggg cttgggaaaa 180
aaagcataaa acgtatggat a 201
<210> 172
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 172
ttgatcctcc gctctgtaga acaaaatttt atttgttgat ttagatagtt tgcaaggtct 60
catctttcct ttgtttctct gcttcagttc tcccattata ntgcgagtgc tagatatgaa 120
atcatattat ataaacaaac aataatagga caaaaggtct tcacagaaca tagttttatg 180
gttttataga tcttctacta a 201
<210> 173
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 173
tttgatgcat acatgggatg ttttcagtgc tgaaaacaat agctattctt attagtagta 60
ttagtattaa attaaaacaa gaggaaggtt attttcaaaa ngatgcttca ctacaaatga 120
agagtctgag agcacgattg tacagaggta aatgaagaaa tggcattgtc tctgcgtata 180
aatgaaagaa gaggagcatg a 201
<210> 174
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 174
ctggaaatta cataataaaa gagaaaaact gtaaaggcgt tatagttgga gggatcaggg 60
gttggtaact tgaatgggat ttgtcattgt gtctgatcaa nagagaaatt attttcttac 120
ttagcacatg aacttaaaac tcttccccta gctgcatcag aagagatagc acaaagaaca 180
aaaagtgaag ttgcattaaa g 201
<210> 175
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 175
atgagccttt gctcccctgg cagttcttgc agtgttgctg gcttcagggt ttgctactat 60
tgtgtttcca gctggcatga ctgcaggcgt cttgctttca ngagctttta ccccatccat 120
acattaagaa tgggacacac tgtaccccaa atcactaaca ccaggaaaaa tgccaatttc 180
aacatttaaa cagtttcata c 201
<210> 176
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 176
ttcttttctt cttactcagt aatcagataa aggcatccag cttcacccac aatttcttca 60
aatacattga aaatggagtt aaatattttc acaggtaagt nactttataa atcaatagat 120
gagactactg taactatatt actagttctt ttgacataaa tattaaaggg ccatctttaa 180
acatatgctc attttttatc c 201
<210> 177
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 177
tttcagctaa aaagaggctg ggaaagaatg gctggctaac acagctgaat cttttccctc 60
caaaaataga tgtagtctca tacatttcct gaaaaataaa ntggactgta ttagtctgtt 120
cttgcactgc tgtaaagaaa tacctgaagc tggtaattca taaagaaaag aggtttaatt 180
ggtccacagt tccacagact g 201
<210> 178
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 178
gggagattat atttattgtg tggcataacg ctgactataa tgaagacaag actttctccc 60
tagtgttcat tttgtgtgtt aaatgtttta atcattttga ncataagggc tttccttcat 120
tattattgca atgcagggaa ggtctaaggt tgtgtttctt atacaatcaa tgataagagc 180
aatttacatt tagaaaatga t 201
<210> 179
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 179
atgtgcattt tatagtctct catgcagcaa aaacccaagt gaaatagcta tctacacttt 60
gtagattcat taaatgcatt ggatacacaa cgaaattgag nttcttattt atggtttcct 120
tcaataaatg tggttttaaa aattccttgt ttgtgaataa tttaagttca ctgaaaggag 180
tttgacgggt tatttaaatt g 201
<210> 180
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 180
ttttcctatc ctaatttagc agccccagtg agggttttga agtctcaagg gaggggttta 60
gaatgttctc ttttttctcc tgctgatgct tttttattgc naggtggatg gtgtttattt 120
tgcacagcta acaagtgagt tcaaagcaat acgttgctct tgaacttttg ccagattccc 180
aaagctgaaa gctcccctgc g 201
<210> 181
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 181
gaaaagaaaa aaaatttttt tttaatttgt cgtgtgcttt aaagatactc ctagtttatt 60
cttccaaact agaagataat gcagtcataa aattgaatac ntgttacctt atgatacaag 120
agcattgaga atggctacag aaatatacaa gtgttgcatt cccaaatgga atcgagcaga 180
caaaaaaaca gcaattcagg a 201
<210> 182
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 182
agacccttac agatcctttt tcatatcctt cttaattctt taaactatct catcaatatc 60
agcctttccc acctttcctt acttcccatg ataattagga naatatattg ctcatcagct 120
aatgctctga taattacaat tatctcctat aattacacta gagcatcatg taattataga 180
ccaagtatag tggaagcata t 201
<210> 183
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 183
tttttaatca gatacctgac ttcagcctca tggaactttt tattactttc tacttgtact 60
ctgtttgcct gcatgtctac tagctaattt cctctggttt ntcacagcat cactgtagta 120
atgtagaaaa tttggatgca gaggttccaa atggcaatta aaaaaattgt atactttgtt 180
ctattgtatt tttttaaaag t 201
<210> 184
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 184
atctttataa acttctacac tattcactca tggctgctct attaacattt tttttctatt 60
tctgtgaatt taaaatagaa tgctttgaca cattggtgta ncattgtgaa cgaagtacat 120
cacaaagttt ctgtttctgg ctaagatgga gtacgtagga agataattac cctcccacct 180
gaagcaacaa aaaatggata a 201
<210> 185
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 185
aggtcacaat tttaaccatg ttttcctagt attttgtctc cctagctatc tacttatttt 60
tttttagagt aaaaatcaga tttggtcaca gtaaattgtt ngtaaggtat atgggttata 120
tttaataaat gttcaaatta atacatggat tttatttaga ttattaactt ctaaaaatgc 180
ccaagtatat taaaagaaac a 201
<210> 186
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 186
aataagttgt gcaacttcct gtgtttactt actgttttga cacatctgca caaaatagaa 60
accaagtaat catctttagt ttttttattc ttgaatcttg ngaggttctg aattatttcc 120
ttcttcatga taaatttaat tcagaaactt attgtaactc acttaggttt attagagtag 180
cctcccatat ttatctccat t 201
<210> 187
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 187
ttattttaaa tatagttatg ataaaaattc aaaaaaattg aaatctttaa tcagctaagt 60
atagatcaat gatgagctgt taaggaatta ctgatcaaat ntaagtttgg aaatgtgtta 120
ataattttac tttattattt tgaatttggc attgtactaa cattatggaa atgcttacat 180
tcattatagg tcatgtggta t 201
<210> 188
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 188
agcaataaaa gtttattaag gtgaaaagct atgtaaatca caaaattatt tacatttctg 60
aatatgtaaa agtaataatc ataaacaagt aatgttgata ntgcatcaca aaattattta 120
catttctgaa tatgtaaaag taataatcat aaacaagtaa tgttgataat gctttattca 180
tcttgtccat ggttaaacaa t 201
<210> 189
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 189
actagaattt gccaactaat aacatatttt caagttatag actagtttgg atatcatata 60
ttttagtttt taaagctcca aatttagcag acatacaaac nataaacttt gttactaatc 120
acagatatgc tctttctcat aaaccattaa taaaagtcaa ggcttaagga gcattataat 180
tttcagaggc ttagttgaaa a 201
<210> 190
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 190
atccaataaa ttacagaagc tcaaccatag aatgcactgc cttcttaaat actatattat 60
taaaagtgca cagtgaaaaa caccttgata cttgatgaga ngttagagtt gagagttgaa 120
aacttgttaa gcttggacta gataatgtca tgagtttatt aaacagtcta gttgctttga 180
ttttattcat cagattattt g 201
<210> 191
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 191
aagaaaatct cagacaaatt taagtagaat caaccagact atcatcaata accagactat 60
tcaataatgt aatttaggtt tgggcaatat ccatagccca natcattaac attgatttca 120
atgtcaaaca ttatgtacat acacactctc ctattggtgt cataaataac ctataaaagc 180
ttggagatct ttgcatagaa g 201
<210> 192
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 192
cctcagagga agaggttggg attttgaggc tgcttgcgtg attgtaattg ctgttacagt 60
aatgtttatg ttcttgtaga tatttttatt ttcactcagc nagataaagg gggaggtgat 120
tgacttttat taaggttaat atggaggctg gcttccgtct tttaacctca ctcttttcca 180
ttttccactt tgcttttttc t 201
<210> 193
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 193
taattaggaa cttaaagagg aagaacatat ggttttgaac atataactta gcagtgtcct 60
agacctctgg cccagctgag gttttcccag gagtaagaac ngagagagag tcggggctag 120
aacagagagt ggccaattaa cctaaaggga atctccagag ggacctagca gagagaaata 180
gcagatggta ttcatttgtg a 201
<210> 194
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 194
ttacaatttt ccaattgttt caaggttcag ttatttatcc atccaaatgt attttaacaa 60
aagatataaa ataaaatatc aaattattat ttttccttca natgactatc cacttttcca 120
atttgttgaa taatacatgt tttccattga ttttatgtca tcttttttac attctgcaca 180
ttcctctctc tttcaactct t 201
<210> 195
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 195
aaatatgggc actcttctgg aataagactt aaaagtcaaa cataagcttt tagacatgtg 60
atttgcaccc tttgttagaa ggggattcta attaaaaaat nagtaagttt ggcatttcaa 120
taacgctgaa aatacaaaca atggcaaagc aaaagaaggc atggtaagta aagaaaggca 180
cagacaacat gaagatactg a 201
<210> 196
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 196
ttttgtttgt aaattgtcca gtctctggtg taacttcatc agcagcatga aaatggacca 60
atacaacttc atttacattt ttataattgt gctttaatat ngagtcttgg ccaagtgtag 120
tgcaaagatt tcttatactt aatgtctttt tgtttttgct taaactttgt ataaatttca 180
ttatgtaaag ctgatttaag t 201
<210> 197
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 197
ggcttctgta ggacagcaac ccccctgagg agttttcttc tctaaattca tcctgccttg 60
aactttacac acacatataa gctccattta cgggaggatt ncagagttaa ttaaacgctg 120
aatttgtttc tttagaaatc gcatatgcct cggggttaag gaatagcgtt tcagcaacca 180
cgttaattta ggattaagca t 201
<210> 198
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 198
atatcatatc ttcccactgt agtcaggatc tattgctgtc aagtttttgc tttatttttt 60
gccaataatg gattatatat ttaaaagaat attggaagaa ngtttgaaaa aacaagttta 120
gaaaacaaaa atcagtgaaa catgaatcta ctatattaca tgaatctact atgttaaagg 180
ttaggaattg agttttaatt a 201
<210> 199
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 199
cttggcctcc caaattgttg ggattatagc atgagccacc acacctggcc gagagtggtg 60
atctttaatg tccacttggt ggaagaaaga aaatggaagc nagaactgag tgggaggaaa 120
cgaaaccgtt aaacctcttg ctttagctcc ttgagagaca agatggacag gcagagatgt 180
tgtagtggac tcaccgctac t 201
<210> 200
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 200
ggaagagagg ctatgaaact cagatgttaa tgtttttcct gtcacactag atttcatttt 60
tcaagtcttt gtaacacggc cttcttaaat tgccaagttg ntatctgtct gcctcccgtg 120
ccaaaatact gagccctgag aagtcagggc cttacctcat gcaaaaacac cgtgttgcat 180
tcctgcgttt ctccgtggca g 201
<210> 201
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 201
attgggtcta aaacggacgg ttctcctgtt aattgctgtt ttattctatc tgtgcaatcc 60
cttggctatt gtggctatca cagagcggct ttaagcacag ncatatggat ccacttacga 120
ggcttcacac taaatttgtt cagtgcttga tcttccatct ctctaatggc actttttttt 180
tgtcaccaac acattcatgg c 201
<210> 202
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 202
tccaaaaaac cagaggaaca atacgattgg ttttcctcaa ctggtgaacc ttcatgagca 60
cacacggaca ttgtagatgt gaaaagcctg aagtcaaaaa ngcccagcca tgctgatact 120
cctgggtagc ctggtgaaaa atatcttgtt attttctttt acctttttgc ttgataatga 180
tttagaaata aatttacttt a 201
<210> 203
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 203
ggggtgtggg gggtggagaa ggcaacaaga atcatattat agtccagtta aaaaatatat 60
atgtatagat ttttataaca aaagacagtt tcaaaataaa ntagtgactt taagaaatgt 120
gtagagtcta cttattaaat taggaggaaa acaaaattga tgttagtttg aattttaaat 180
gccttgtttc acctctaaag t 201
<210> 204
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 204
ataatctgta gttgtggaga ttaagctaag taattcatat ggtgtaacta gtacacagaa 60
aactaaacaa ttttttcctt aaatatctaa atgatgcatg ntaactggtg gaatcaaggg 120
attaaaagat agccattgag gttctatcac agcaaggtcc tattttggga cgtatgttgg 180
atccagatgt atattctact a 201
<210> 205
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 205
ttacttacac ataaaatatt tatatttgct aaatgaaaat tataattacc tctaattcaa 60
ccattcagac aaataaaata atatggaaga aactcagttc naactttcta tataacagaa 120
aagaaaaaaa caagacttac tgtgcactca ctctttatga cagactttta acatttaata 180
tatttcgaag catttcttct t 201
<210> 206
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 206
gacattcctt aaagagtggt agcttcttat aaccatgggg tgggggaaag ccacacatta 60
aggacagtgc agtgtgacta aaagaagaga ctggagcatt naacaattgc tttagcactg 120
aacacatcag cctggggctc attatagcct gcaaaaaaat tacttgttta acatacactt 180
tgttaatttc tgttacatga g 201
<210> 207
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 207
atttttaggc tcacaaaaac agacaaaata tttcagaaca ctgctgtctt taaatgaacc 60
cagtgctaca cctacaccaa tactgtctca ttttctcacc ngtactggag tcctgtggct 120
tctgtaacat attaccatga agtctgtggc ttaaatcaac aggaattgtt ctctcgtcca 180
gaaggccaat caatctcact g 201
<210> 208
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 208
tgttcagaaa agcaaacaaa aagtcaaaca tctgtggctc tagatgataa tttagaaccc 60
ttctactttc tgaattgtgt aatattttaa atcccaaatg ncttcagtat tactccaaag 120
attgctgcta ttacacagta tccaaagcta atgttaatac ttctgaatag agagattaaa 180
aacaatatct gaagacccaa g 201
<210> 209
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 209
tgcattgaat tgttttgatt tgatgctttg caaccccagt gttactgggg tacacaatga 60
atattgtcta ctaacacata tatatgcaag tattcacctc nattgcttca ttttggagac 120
tttttcagaa gtaaatagaa tatggattct ttaccccaaa ctaaaactta ctgaaataac 180
tttgagagtt gtaataaaat t 201
<210> 210
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 210
agatgtataa tacatgttgg taaagaaaac tgtaagtttg aattctagat ccagatttgt 60
cccatacaag ttctatatac ttggacaaat ctcccaatac ntcggttagc ttttctttat 120
tttttttttt ttttttttga gacggagtct cactctgtcg gccaggctgg agtgcagtag 180
taagatctca gctcactgca a 201
<210> 211
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 211
taaatctgat ttgatctata acatttagta acacactggg cttcttatga taaggtggca 60
tcatttagaa gtaaaccaga aacaaggaca aatagaaaaa ngtagtgtag aaaatgatgt 120
aacagtaatt tgaatgcctt taaaaaaaga tagcaatgag agttacaact ggccacagtt 180
gtgcaaaaat tagtggtgaa a 201
<210> 212
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 212
ttatatattt tatatattgc cagttttatt gttagtagta tattttattg ttagaattaa 60
tttataatta ttattgtgtt aacttaaagt tgcctggaaa naagtaatag aagtatattg 120
tagaagtata tggtcttgct tccaattagt gggataaaat ggtgagtgca tatgaactaa 180
gatgacattg cactgtgtca g 201
<210> 213
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 213
ccctgtttag atacatattg caaggcaggg cacaaaagga tgatggtggt gggcttaaga 60
gatgtaagta atagagcata agaatctata gcataaaaga naatgatgtg aattaacact 120
gcagcatcgc tcaaaatatt taagagtgtt aagcaaaact aaaattggcc agaggctgcg 180
gctatacctt atatcctaca t 201
<210> 214
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 214
tttattcctc acttactgtg ccctcatgct cgtctcataa aacaagacag caataaggtc 60
gcaaagtttc tctcccaaag gccatactca tggttcctct ngacctcttc atagaatacc 120
agaacataga agctgtacac ctgctgcaac tgcccatatg cttctgtgcc agatgcagct 180
tgctggaagt tcatgcatgc a 201
<210> 215
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 215
atggtgtaag ttgaagagct cttctaatac acactttctt tgtttgtggt tctaaaaaga 60
gttgagctca gtacggaaag ctcattacat tcactataaa naagcagcct tgttctaaga 120
tattcctgct gggtaatcat cattgtgaat atatgtacat ctaagttctt ggttagcttt 180
ttttccacac ccaccccctc c 201
<210> 216
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 216
tgggccccac ctgaggttta tggaatcaga atctctgaga gcttagaaat ctgcattccg 60
caagccgctg ggcgatttga tatgtatctc accttttatt nttttctaaa ctgatcgttc 120
tccttcattt tcatcaaaca cccattaaat attttcatca aaaccatcat gctctcaacg 180
caagacattt gcacttttgg t 201
<210> 217
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 217
aattttatta gtagcaatag tagcattctc tgaactttaa cgtatctttg aaatttagat 60
tgacccaaag ttgaataatt tagttaagca actagtctga nagaaacatt ttattggctt 120
caaattttta gttgggtaaa ataaagaatc accgtatgct atatccagaa agcattaatg 180
ttgtcatttc atgaatgcaa c 201
<210> 218
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 218
aatagagcac cttttttttc ttgaaacatt tttgtttcaa ttttcaatta ctcatgtcaa 60
agcctgaaaa tattccctaa tagaattaaa atatatctgt ngaaatgttc atggatttta 120
attaaagact gctgttgtac ctttaggtaa agaaaatata atgatgactt agacaaaatg 180
actaaacatt cttaaattaa t 201
<210> 219
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 219
gggttttgtg tgatgtgggc aggaagcctg actttcaggg aacgggtggg atgtggtgtc 60
ttgatgtcca ggggaccgaa gtgtggccgc atggtctctt nggctcagag cagaactgac 120
aaccccattt gcctgatggg gaaactgagg cccagaggga atgatgtggt gtgcaacagg 180
tcccatggag accaggagcc c 201
<210> 220
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 220
cagatttgct ttcttcttgt gggaaacctt ctgcttgggg atacctgacg attaactata 60
catacatagc atatatatac atgtatgtac ctgtcaccag natttcttac cataaatgag 120
cttcctatca ttctgaaata tccaaagatg cctgaaacat tcttcaaaaa atttcataaa 180
ttgagtaaga ataggaacta t 201
<210> 221
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 221
caattgattt gtcagagtta tctaggtctc ttggacaaca accaacaaca atgacccact 60
acaacttcac ctcatgtatc ttgaacttta gggatatagc nccatttaaa gagactaacc 120
tctcttggtt cttgtcagtg aaactgggaa gaagaatttg gaggtatcca agaaaggtgt 180
cttatctaag gaaaaattag t 201
<210> 222
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 222
ctatcaagat aatggtagta atgaaaaccc caagaagaga caggtctaga aaactagcaa 60
cagtcatttt aagagttctg cctacatgta agatataaaa ntgatgtaag tggctatacc 120
ttctctagtt tctgcctttt atttctacaa tgttcattaa taaaagtgcc tgatccaact 180
gataaatcag aaaacacctc t 201
<210> 223
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 223
catatcttag taaccagtaa ttagaataga agtttgcatc attcttttta aaaatatgtg 60
gaatgagtta cttctttgtt ctgttgttta aaacttgctc nggtgatgtt aaagaatttc 120
tcctctccac cctggcactc atagtgcctt gactaatctt cccagtcagc agcaggagtc 180
ctaaggcaaa gtcaggcaga t 201
<210> 224
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 224
aaagaatttc tcctctccac cctggcactc atagtgcctt gactaatctt cccagtcagc 60
agcaggagtc ctaaggcaaa gtcaggcaga tgcgggaagg nacactcatg atcgctgatg 120
aggcctccta ggaaccacaa atctgttatg gggggatttg atgctgctta tcaagtatct 180
agtgagaata aatgactggc t 201
<210> 225
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 225
ttgtttacag taagataatt tgttttaaca cagaagatat ataaaagaag tcagaaagac 60
taagataatt tctgtcacta ggggcagaaa gttatcagga ncatggcaga gataaatcta 120
ggaatgcaaa aagaaaggtt acgatggaaa tggaaacaat aagctttgag aagttcaggg 180
gcattttgaa gacagtatta c 201
<210> 226
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 226
catggcacac atttacctat gtaacaaaac tgcaaatcct acacatgtac cccagaactt 60
aaaatgaaag ttgatatatt tcttttaaaa aagctctttt ntcacatgaa aagaaattac 120
tctgattcgt tcatctgttt aactatgtaa tggggtaccc agactttgtg tctttctgat 180
gtggctgttc ttaatgtttg a 201
<210> 227
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 227
ctttcattcc agacaattgt actaaaagct gagccactgc tatatgaaat catctgctaa 60
gtcatttcta ctgtgccaaa attttagact gagctaattt nagataaaca tagctctttc 120
acagatactc tctatagaaa gttgtttttg tctctttctt cttttacttt ttactttctt 180
cccttccctt ccctttattt g 201
<210> 228
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 228
cagcctctgt ctacaaatcc cctgaaactt tacagttgtc aattatcaac agtcatctta 60
catatgttcc tataaactct atatatttct aaaactttca ntcttcaatt gttattttta 120
ccaatagcct aatgataaaa tattctgtca catatcttga aagctgcaag agctttaaaa 180
ctgccatatc agtaatgtta c 201
<210> 229
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 229
ccctaagtcc aaaattccct ttcaataaaa aggggaaagt tgggttcttg gcccacatgt 60
atcctcaata cattgccaaa tcattctagc tttcgaatga nttacctgat gcttacaaaa 120
tatgaaatct ttctgagcct tctcaaatca aaatggaaag aaaaatactt cagattgaag 180
atttcaaatg cgagatctga a 201
<210> 230
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 230
acctaaagaa tcacagtcag caaacaaact gtgtcactaa ctctctgggg cctcgtttgt 60
gattctttag aaacccagac taccttcaca ccacagtgcc ntgtattctt cactgacaga 120
cttggaatta tcactaacca ctcagatatt ttttagctct cactcatccc ccaacacaca 180
cacacacaca cacacacaca c 201
<210> 231
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 231
aaattgctta ttgttcccag tgtcctggat acacctgcag atgtgcagtg acacagccag 60
cgtgaaaaaa ctgtaaagca catcatgtgt gtcttttggg nctccctctc ccttacagca 120
gtcatctttt tctgcctcct aggactcctc tcccttctct ttgtaccagt ctggatcatt 180
ttcttattct tccccatgga c 201
<210> 232
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 232
aaattatggt ggttagcttt tgtctgacaa aatggaaacg gagtgaatgc aaaatatttg 60
gaatatagtt tgtaggtaga aacaaaggaa taagagtcaa natggtttaa ttcagggcca 120
tgttgtatct cttatcggcc ttctgcactt ttgctttcat ggctctttcc accatgaaaa 180
caatattaag aactgtattt c 201
<210> 233
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 233
taggaaagtt accttcaaga gaaagtggat taactcaggg atcaactgag agctaagttg 60
taggatgaca tgaggctaag cctcaagatc tcataagtgg ntctcatttt ttgaaagttg 120
tatctatcca gaggttaaac acattgtcat tggtcacagt ggtgcagtgg aagaacaaaa 180
ttggtactga aataaaaata t 201
<210> 234
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 234
catgtctgtg tttggcagaa ataagacgca gctaactgac acaaagccgc ctttatgaca 60
agggtgcttc catttttcct aattgcatag atgttccctt naccttcgac cttataaata 120
tgtaaagcgt tatggacgct gattccctct actggaatat tgccgtttct aaactttgag 180
ataatgagtt ttgaggggag g 201
<210> 235
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 235
atttctagtt ctagatccct gaggaatcgc cacactgact tccacaagag attctggtat 60
gtggtgttcc aaagaccttt atttccaggc caatgcctaa ntctatggcc ttactaagca 120
ccatgttgtt agcttatcct tagtgtgaat tctttgaagt tcctttgcat ttacccagct 180
aattcatgcc tgcatgcctt t 201
<210> 236
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 236
ttttaaagag atctttttga atgctgtttt actttttatt tacaatgtaa tcttcatttc 60
attttataaa gtgaaaccta attttaaagt atcttttgtc naggaacatg ttggtgttta 120
gaattagctc tatattaaaa cttgtctgca catttgcatg ccatgcaata ttctggattc 180
cacttccttt atcaggaaga c 201
<210> 237
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 237
aaatgaggaa cgtagactac ttctgccccc ctacccctgg atctgactac atattggttt 60
tgtccccagt tcttctattt gggggataaa atgaaattac ngtttcacat actatataac 120
taccatagag ctaccacatg aatacattgt gaacccactt tttggctgat ttgttcagaa 180
gtgaggacct agtcttagaa g 201
<210> 238
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 238
tagatttaca gtatgtgaag acaataaaaa taggtgaggc tgaattaagc taatactcta 60
acttacttgg aatgagtatt actaacctac actttactaa ngaatattgc atgtctataa 120
ctagggtcat caataataag acaatgatac atttttttaa attaagttct ggggtacatg 180
tgcagaacat gcaggtttgt t 201
<210> 239
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 239
tataatgcat attatactaa ttataataca acttctaaac atgacagaat acatgtgcct 60
taaattaact tcatttgaat ttagggagag taggatgata ncttcaaatt tatattttct 120
ttaaaagtag acttctccca attcttgtta tttatccact caaatgaata tgtttctcta 180
aggtaatcga agtgtcaagg a 201
<210> 240
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 240
taataaaaat gataattgtg ctgttagtgg ttttattaat gtcattgaag ttagagcagg 60
gagatgaatt actttatgga gaaagaagat aacacataag naccacgtag ataaaatgac 120
cctaggatta aggccttaga agaatgacat ttccaaatgt gagcctggtt ttacacagta 180
tcaagatact tgactggaaa c 201
<210> 241
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 241
tcacaagatt ctatgtgata tgcttggcat agcatgtttt tagtatcagc ccttctttcc 60
ccacatatcc catgatttcc agaatctctg cattttctag ngaccctact tgtcttatgg 120
aatctgagta ttccttcttg ccttgccttt tacatatatt ggtgtgtttc atcttttaac 180
tataactccc tctgtgtttc a 201
<210> 242
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 242
tattgttgta aaacatttca ctgtagtcat atatcagact ttaaaaaaga tgcctctaat 60
atttactctt ttaagataac ctttggttta ggttttccat ncataccctt aatagaaaag 120
aaagtttaat tctagttgta aatcaatatg taaatgttaa tattaattta tttagaattt 180
tatcagttct tcaagtatta a 201
<210> 243
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 243
acgaatgctt tatgcaacag caaagcactt ctaatcctgc tgcttttgtg tgaaactatg 60
cagaaagatt gcctggcacg tgtggaatat aagacagatt nttttaatac agcatggcag 120
tcagaagcat tcattttgtt tagtctgtgt ggtatttggg ggacattccc atcagggagg 180
cactgtttga atgcatattg t 201
<210> 244
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 244
agaaaaaaaa aagtagcagg tctgtggaat ttttcctgag atgcatcaaa gggatagaag 60
tacagttcca gttgttttcc tgtgccctcc tttaattacc nagtttctgt gatgtcacaa 120
tctagtttgg aataacctta tcaacttcct gactctttct tcttctatcc tattttcccc 180
ttgtctcaaa gaagaaaact g 201
<210> 245
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 245
tgtctcatat aagcttgaat gtttaacccc cacagagctg cattttaggt atacgtttgc 60
acagcctatt gtcatatttg ctgcaaactg aactaggttc ncttttcaac agtaaaggaa 120
atgccaatca gaatttgtaa atgccatgtg cccagtgaaa ctacctctca tatgatacag 180
acacagaatt catgatttta a 201
<210> 246
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 246
tccatacagg gatttttttt tttttttctg aggcttctta agaacaacat tgcccttaaa 60
tgtgtggatg agtcttttaa tgctgatgcg gtctatgctt ngagaccagg ctcatcatac 120
ataatacagg gcttccgtac aataaagatg aataaatgag ttaaaacaga ttttaatttg 180
ttaaatataa acatataatt a 201
<210> 247
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 247
ttgcatttcc cttctcgctt tacctttagc ctgagtctat agcatgaatt tcacagcctc 60
taatcttcac cagaggccag gagttttgtt ggggtggaga nggtgtgata ctgaacatag 120
tgtcttagca caaattagct gatctgtgtc ccagctcctg acttgctctc acatgtacac 180
ttattgttca gttataatcc t 201
<210> 248
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 248
gagaccccaa ttacagctct ctccattgtt caattccctc tcaggaacct aattactttt 60
ctgctaacag gactttgcca gcaatattga cactgatacc ngctataaga agtatagtgg 120
aagaaactgt ggaggcaggc atcctgggtc ttggctttgc aatctggtct tggcaaatcc 180
aatagatttt tctgagccac t 201
<210> 249
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 249
cagagtagtg cagattcttc ttggctgctg aatttttctt caagcattct tggaatctat 60
taccaattcc tgttctttag aacccagtaa ggggaaagtg nctcaatgca gactatattt 120
tcttgacctc atcttttctc tgccattaag gtgaactaaa ggaagcaaca caatttcatg 180
tttagtcacc acagagtcag a 201
<210> 250
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 250
tggcttttta ataactagct tagtagttag ccgaaaaatc ttagttttta aaaatacaaa 60
aaaaaaaaaa aaaaaaaaag agacagtctg atagtttatt ngtttttcca tacactctta 120
attgaaactc agtagcagcc taagataaag caacacatcc gatgaattaa aatgtttcac 180
agaatcttta ttacttagcg t 201
<210> 251
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 251
tggaagattg gcgctctgcc tcttcagcct caccccatac gtgacaagga cccttgatat 60
ctcttgttag gatttaatct acccttagct atcagaacaa ncctgttctc aagagaaact 120
ctagaagctt tggttcaaga attcagcaac tgggactctg accttgtgtc ttggttctag 180
taacgaggtg attgccttcc t 201
<210> 252
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 252
cgccttgtgt ctgccagggc tgtgttgctt tcctggtcct ccttcatttg tggggaggag 60
gtttatagga tgtttggaaa tattgttcca tcatctttgt nctccaactc agctcttacc 120
agaggcccct gtaaaacaaa tctttacttt tcagctagat aagttggtgc tttatttcct 180
acttggacaa tatctaatca t 201
<210> 253
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 253
tgacctcagg tgatccaccc acctcagcct ccccaaatgc tgggattaca ggcatgagcc 60
accttgcccg gcctcttcct tgaattttga gtgaccctgc ntgtccctga atgtctaatc 120
ttcattgatt tctatctgta aatggggatt tattattgtg cttctgaacc cttgtggttt 180
ctttttaatt aggataaatg a 201
<210> 254
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 254
attatagctg catagtattc catggtgtat atgtgccaca tttttactag ctcaggattc 60
acggcaagcc catttcattc atttgcctgc atggttccaa nccctagtta gtttgttatg 120
gcaacagagc agtcattctt gctgttagcc actatttgtg gtttcctcct tcaaaagact 180
aagttcattg aacttcccaa c 201
<210> 255
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 255
gggcgttttc ccagagtcac taggaaaata gctttgtgcc atctgcacct gtcatgtcga 60
ggaccaagac tctaaaaact ggccaagcaa ctacaaatgc ngcagacagg caagaggagg 120
agacccaagc tccgtgctct ctgctatccc aggttcactc agccagcacc atctatatgc 180
tgatgattcc tgtatttaag t 201
<210> 256
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 256
atggattctg ccctgaagaa attcagtgtg gttgggagat aaagcatgca tgtaattgac 60
atgcacgtaa aaggagggta gaaagttgta aattccacaa ngaaagcata gctcatgtgc 120
tatgggcccc gatatgacat taatgtttag caagtattca tttacacaca gacctgcaca 180
tttctcacga ggagagtatg c 201
<210> 257
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 257
agatgttagg gctttgatca gagagattat gccaatgacc atgtacagca gtctcagctt 60
tggacaaatt aatggctgtg tgtctcagat caggagacca nggtcccaga tggagctgtt 120
aggggctcta tttccccttc cgaggagtgc ctacctctcc actgtgttct ctccctgagg 180
gatcaaatat gttttagtgg c 201
<210> 258
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 258
taagcatagc aaagaaaaga aacacatcat atccccttct aatagacatg ggacttggaa 60
ttcattcata aagagaattc caaatctcat gtatgagccc nttttgttaa gcaatagacg 120
tttaatatga tttcattttt ttttcattct ttcatttggc atttgctaag aaattcttcc 180
acgtgtttta cattctctat g 201
<210> 259
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 259
tcatgtttat atatttccct tgttaaacaa agccatttcc tcatagtttg agagtattta 60
taaattccca ccttgagttc aaattaatga agtacaatga ngggtggatt tcagacagtg 120
caagctggtt tgacctcaat ggtgatagaa aacatctgaa tttaattctg tccctgtcta 180
ccctattctt ccctctttct c 201
<210> 260
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 260
gtctccattt tgagtattta tattgaagcc ccattgtata gcacccctgg aagggactct 60
tgctatcttt ggcccacaac ccataggata gaggcactag nactgagagg aatgagctga 120
gcaggctacc attgactaaa taggtctcta tggcattttt catagtaatc tgccttagtg 180
aagatgccat gggcaataca a 201
<210> 261
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 261
tctctcaaat ataatttttc caatatattc tgtataagca aataaataac aaatgacaca 60
gagaataaag atccacttgt ccttaaaaaa catagggggg naagcagatt tgtgaaggct 120
gctaatgatt gtggtcactt gcctgcaaat cataatggcc aaggtcagaa gtgaaataac 180
ttccaaagtg gtaacctgga g 201
<210> 262
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 262
gtgagtacaa ctttgttctg tttttcaaga ttgtttagct cttctggata aaatattcta 60
gtcttaacag ctattgatta tttcctttat gtgaatagat nggtgggaga tagatgcata 120
agacatgttc atctaccgaa tacatgcaaa tctaccttac tcagtcccca cacatatgcg 180
gttccagcga ggttgtaagt t 201
<210> 263
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 263
aacatttaaa aatcatatct tcacattagg atatcaccta acctaaaaac ttgccaagaa 60
actacctaat ttaagactat atattgagtt atttgagata nttgtttaca taatagtcta 120
tgtttcttta ctgaagcttc ctttgcctaa attgattagt ttatgactac tctaaaaaat 180
ctatattatc tctagattta t 201
<210> 264
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 264
aaaaatgaat aaaggaacat gaatggaagg atactagaaa gagaactatg tttaaactat 60
tcttaattgt aatttaatgg ccgatatgtt ttgtggggag nggaggatag ataaatatgg 120
tatctgtaaa tactattgaa atgaattgtg tattattcaa agacatatta aaatacttgc 180
gttggttcct ttggaaataa a 201
<210> 265
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 265
ttttctgata gacaggttat tacaatcaag tcaagaaatg attgcatatt taaacgtgtg 60
attatatcat aattcatatg ctgaatatat gaattactaa ntaggacaac tccaatgctt 120
aggacataac acatacaccc gagtaatatc tttttgtttc acatctttct aatgaattcc 180
ttcccactaa attattaaat c 201
<210> 266
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 266
agcctggggg ccaggatcct ttcctccccc attagtcctc attgtgaaca gggaccattc 60
cctcctggcc ctggaagtag cctctggagg cccagcaata ncctgatgca aaggcaagag 120
cagctctctc ccctgggcaa cattcttcat gcactattag gatcccaatt caaccccttc 180
cactatgagc agcacaagag c 201
<210> 267
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 267
ggatgctctc gtaaaaaggg tttgtaaata atttagcacc cccaagtagt agattctaag 60
tggcaaacag cctgctgaga ggagggctgt agaggcccca nggaaaagag aactcaggac 120
aaccagcttc acaagagcag ggaccatggc tgctggtcac caccataccc ccagcacctg 180
cacagttctt ggaccatggc a 201
<210> 268
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 268
aaagtccaca tttcagcgtg gctgacagtg tactcggggt atggtccctg tatctctctt 60
gagtctcatt tttcattatt atcaaatgct aattatcaaa ntgctcatgc tttaatttgg 120
acttgtgttt ttggtatacc ttcctttact aggcttgata ggaagctcat ggttcattga 180
aggcaacaac aaaacccaaa c 201
<210> 269
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 269
accaccatta ccaacaccaa caacaataac aaaacaactt ttgaagtgcc cagagtagaa 60
aaacacatag ataacacaca gattataact ctgagccata ngtggcaacg aatttattct 120
ctcattgaat cctcacaacc taattaggta ggcactaccc ttatcactat tttacaaatg 180
acaaagccaa gtcccagaga a 201
<210> 270
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 270
agactgtttc ttcatttttg caataggaaa aaacttcctc tatttttttt ttcaatattt 60
ctctcctaat gtttctgctt tggctcagag agaatggaga nccctgcttc ctttactcat 120
cttgggcagg gccaggtgag gggactttgt ctctttgctg acttcactca ccagcttctc 180
acaaaggcaa gaggaattgc t 201
<210> 271
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 271
aagaagctca aggtgatagc caagccctcc ttccaaacag gaagaacagg tgcaagagtt 60
tgaggtgaca ccagagagaa ctgtgtgcct ggctgcgcat nagattgtgg gattatcaag 120
aaaagttgga aagcgggaga tgaaaaggct aaactcaaag gcttttctca aggaaggatg 180
gtcttgtttg tgtcacagtg c 201
<210> 272
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 272
ctccagggac tgcggagtag gggtgaagag agaggcctgg agatggagtg gggcatggca 60
ctcagtgatg ggggacgggg tcggggatgc gaaatagtgg ntgttgcaat agctcatgga 120
gttcccaatg cgggtcagtc ttctggttat gggtcactct tgaccaccca gggtgctact 180
tgtgactgac tccctaatgc a 201
<210> 273
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 273
atagctgtat gtgaacacac atacaggttg tgtgtgtgtg tgtgtgtgtg tgtgtgtttt 60
atgtgtatac acagattttt ttttctagtt ttaacaaaca ngaggtcatg ctgtagacaa 120
tactctgcag tttgctctct tcagatcgaa cacatggttc tgaaacacaa atcacatcat 180
ctctgtcctg gctataacca t 201
<210> 274
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 274
gcaaatcatt cagcttttcc tcagtgcata acttacataa ttatttattg aaatagtgat 60
aaatgagtct gaaatattga tattctgcaa taaatggtca nttttaatta tgttcaaatg 120
gatgctttgc ctgatagaat tctgtcatat taataaatgt tgcagagaaa acacattcct 180
tatactaacg aagggacaac a 201
<210> 275
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 275
caccatggag accgagagct cctcagtggc agccacttcc cagccaggga cccaggggca 60
cagttccact gtgttggtgg atttccagac atttccaagg nagggttctt ttgccacctt 120
ctcgctcttg cagcttgctg ggagtgagag cagcacgtga gtaggggtct gtgtagggtt 180
cacatccacc agcccctgac t 201
<210> 276
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 276
ctaatcctct ccctcctccc ctcatctgcc ctctgaatgg ccctggtatg attttaaaat 60
ttcattattt ccttcttacc tgccactttc caagactttc ntaacatctt ttcttgatac 120
tttgaaatcc ctatgattct ttaaggtcca attacctcca tgaaactttt cttaaaattt 180
caaaccaaca gctgtgtctt c 201
<210> 277
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 277
tgatggaatg aggtttccaa gggtgcagtg taatggttag aaggtgcggc agccagggtg 60
agtggggtag agatggagcc tgctgaaagg gattatgcac ntgagaaaaa gtaaacaact 120
aaaggagagc agaaataatc aaaagcagag tgtgtcaggc ttatgactca aagcagtagc 180
catgaaagtt gttcggctga a 201
<210> 278
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 278
cagctgtggc agaatgcttt ttcgacaggg agaaaatggt cagatgtcat ctatttgctt 60
gaaagaaaag aaaatacatc tcttagcatc cagcgaaaat nataatgctt aaaaaaaaaa 120
gaaaattgca aatccattct agctttgatt cattagagag ttcacagcca agagagagaa 180
atgaaactct agctgaggtt a 201
<210> 279
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 279
tagtgccaat tatctcacct agagccacaa gtgatagttt ttatgacctt ttataaaagt 60
ttagagttga aataacatga aaaatctaac ccagtttccc ngtttttcta atggtttctt 120
agataatata attaaatgat gactatgcaa atggacagtt attctgtgat gcttcagaag 180
gaagtattta aataaacaag c 201
<210> 280
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 280
agagcaccct gagaaagtat aatagatgag gcaggtacat ggaggtagca ttcactttga 60
cattagtagc aggtcattaa taaggagaag gctgaagcta ncaactgtgc tcaacgtacc 120
accttgcaag ggaagtgatt attgacttgt gctacacaaa tattttaaga cagcagaaaa 180
atgcatttat ctcctataat t 201
<210> 281
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 281
ctactaagaa aatacccaag ctctctcttt ttaagaaaca aacaaaatta tattgtttgt 60
tactgagttt tattattcaa tgccagaaag ttggtggaca nttaaaaaaa tcagtatact 120
ttagtaaaat taatatattt gaatagaatc tcatttaatt ctactcctaa aaaatttagc 180
tattttcatt caaaattaat t 201
<210> 282
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 282
gaccttaaag ttggtaacta cccttagatg acctttcacc cttagccttg ccacaagttc 60
tccagccaat ggcattgagg agggggagat gggattggtt ntattaatca gcagctgtca 120
cagaattagc agaatccaga ggaaaccctg agcatgcctc agaacccaag gagaccctgc 180
aggttaaaca tgcacttggt g 201
<210> 283
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 283
tggggaaatg cagagagaag aggagattgc caagagctat atagaaattg tgtgtgtgtg 60
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt naacttatga tgctagaaga 120
gaaatgataa tcctatcccc aaagctgcca ggaatttcca atgcataacc cattatacac 180
cactaacatc acatgggaca g 201
<210> 284
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 284
gtctcactgt agaaagactt gatcgcatat tgaaattgac tgtctatggc aagtgtcaaa 60
aaatataaaa ataatatcat agcttccttt gtacctcaaa ntaagtagct tcatattcct 120
ttgctcatgc aacccaatca tatttgggaa gctgcagatg aaaagcatac tgactttttc 180
ctttaatttt tagtgaattc a 201
<210> 285
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 285
acctgaccag gatgtttaag gtaagaatat tcaataaaga taggtggtgc ttacaagtaa 60
agcagtgtat tggaaagata ataggcagtt ttgattgtca natagcagta ctattttaat 120
gagttgagca aagggataaa ctatgtttaa taactatggg tttaattgaa ttaaacactg 180
gagcatttac ctcaatgaga t 201
<210> 286
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 286
ttgtttttat gaatcatctg tcatagaatc tgatgatata taatacttag tcctttaaag 60
gctaatagca tttctgtgat ggactttata tgtttcaaag nctttcacat gtattgaaac 120
agcatcttga tatagacaag aaagactagg gagatgaaat ggtcctgagt caaccaatac 180
agaaacagaa acaacggcta c 201
<210> 287
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 287
tcaactatga agccacctcc catattaaaa accccaagat gccacttgtt ctccccttta 60
atgaaatcta cccgatgctc ccccataggt tttagtttga ntatcagact tattctttcc 120
tcaagcttct ttcatccagt caaacaataa gacacttaaa tttccagcag tatattttat 180
aattgcaagg cttctgcgga a 201
<210> 288
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 288
agaagatctc tggccagtat actcagaaag ttataagcaa gtgttacatt catcacatta 60
tatgataact attgtcacta aatacttgat agctatttca naatcatggt cagccctgca 120
ctgtgtaata atgaaacaaa tgttaacaaa atggtgaata cattttctca tatagcatat 180
aaatggattt tgcatttaat a 201
<210> 289
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 289
tggtaaatgc aaaatgtcct gtttcagatg ctttatttat actccttcta ataacagcta 60
ccttgagatt gattaagctc caaatactag ttaggatatt ngtttaactg ccataataaa 120
aagcaaatta ataattaggt ataatagaat ttatttttgt gtgtgtaata ggtaatgtaa 180
gcaatccaag catgacacag t 201
<210> 290
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 290
ggcacaaacc actgtttcat ttttttattt tgtcgtactg gaggttatat tcacctgcaa 60
atgaggtaca aagagccaaa atctttaatc agaatcaaag ntctgtgctt actagttacc 120
tttgtactga caaggagttt cacacaaata gaactgcaat aatgtttatt ttcctggcag 180
ccaaaaccat aatgctctta c 201
<210> 291
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 291
aagacaatgt gatttagata agtaatataa tagcgcaaag gaggagcacc cacctgtgac 60
aagggtaatc agagaagggt ttggataaga agtgatatac ngaaagtgat acctacaaac 120
atctcgggaa ggtagatggc tatttctcaa atgggaaaga aggtaaacat ttcagcatta 180
aggaatcatg tagttgagca t 201
<210> 292
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 292
actaacactg agaaggcaat gcaaaccctt ggcatttttt gtcttagtga aggttctact 60
ctaagccatg gttcccatgt agatctccta agtctgactt ntccagtaat tttttctgtt 120
tctctgaatc tttaagtcac agttttgaaa acaaaggcta acctgattaa gccttccaaa 180
cttaatctgc cttgcttgct t 201
<210> 293
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 293
aatacatgct tatgaggtaa ttaatatccc catattcagg taagaaaccg tggtatcgtg 60
agcttaacgt cttgttgagg ggtacatgga gagttttttg ncttcttggt atctggtagg 120
tagtaattgt cagccagcat agtgatggga aagaacatat ccaatgcatt ctattgtgga 180
ggaactattt atatagcatt g 201
<210> 294
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 294
gttgactgat ggtggaggaa ccccaaaata ctttgttgcc ttctacaaaa actagtatag 60
tcagtagggc aaaaatcatt acctctgctc tttatttttt nccaaatatg gagtgtgtat 120
catgtgttaa gtaaaagaaa tacaaatatg gaattgtcta ctgttgtatc ttctgcatga 180
gaataacgct tggcccatca t 201
<210> 295
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 295
taaattgtta tgatgtggcc aggtttcttt gctctctcta caatacctat ttggtattca 60
ggacattttg attgactgat tatcatatac actatccttt nttatagcca tcagagaaat 120
agtcttaagg agatatcttg catttatgtg gcattttaac ctttgtatta acgtgtatta 180
tcatagtaca ttctcaggat a 201
<210> 296
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 296
attttcatct tttatggtaa ttcatgtagt cattcactgt tttcaaagtt gtttcttcta 60
gattatctca ctatgtccta aaataatact tatgaatgtt ngtccagctg gctactttaa 120
tttccatccc ttagagtcag tggtgacctg gctgtcaatt ggtacaggtc tgtccagttc 180
ctgtcctgga tctgcccagt t 201
<210> 297
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 297
acatacatcc atcttctgga attcttctgg tttactcaaa tactcataac cttcattaac 60
taaaatccct cctctgagaa attacttctc agaaatgtga ngtatctgtt cctttctcag 120
acttccattt aacttttaag cattcatttt cactaattat ttaacaccca gattgtgcca 180
tctttaatat cagggattat g 201
<210> 298
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 298
ccctcctctg agaaattact tctcagaaat gtgacgtatc tgttcctttc tcagacttcc 60
atttaacttt taagcattca ttttcactaa ttatttaaca nccagattgt gccatcttta 120
atatcaggga ttatgtatat tacttctata tttatataat tacaatttgc attcaagtat 180
ttttgatgct ttgattatat c 201
<210> 299
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 299
agtactactc agtctgagca tgcttatgtt taataccttt ttatggaagc aaatttgctt 60
tgggtaataa cagaatatag ttctgttatg tggtttgcta nctttccctc aaccaaggac 120
agattttcaa aatctcactg agaaaaataa agcttgtaag gagttagggg aggaatgtgt 180
aatcgaggtt tctctgaatt t 201
<210> 300
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 300
acatacttag ggattatcag caaactcttt tcccaaacct ttgatatatt taaatgaaat 60
aaaaccccta ggtggctttg aaaacagcat ctttggcgca ngcttttatc tggagacatt 120
tccccaaata ttttttaaaa tgtgcatgca tgtactgtgg ggagacgggg agaaaatgaa 180
cctcattgaa ctgcaattca t 201
<210> 301
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 301
ctaggtgcct tggaaaattc tgtcaatatt agtgttagtt tggagaactg tcttcagaaa 60
tataagacaa cagtgatagg aaaccaattt gtgacctcca naagtcattc catctggttt 120
gtggaggatt atgagattaa cactacttgt tagtgctatc attaataatt atgcctctgt 180
atatgtgtgc agaaatttag g 201
<210> 302
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 302
actaatatta attgaatgtg agttcattga gttttatttc ttattttaaa gttctcttgg 60
tgggcgcatg ccatggtgca cagagaatga tggatggaaa ngatgaaatt gttaataaac 120
cctcagaccc ctatggccca ctgggcccac agagtatgca ggtttgattt tttttttctt 180
tggttccagc caccaccacc c 201
<210> 303
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 303
gccaagcctg atgaatggtc caattctatc aattaatatt tttgaatact aatttttttt 60
aactgaagac aattgactga tgaaagattt agctgattta ntttggctga gtacttcagt 120
tgtgtatgta gattgttgtg gttttcaaag accaaatatg tcagggaaac atctttaaat 180
agtagaaata cactggatgc t 201
<210> 304
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 304
atcctctaga gggtgacaaa agacgagata tatagctatc ctcaatttga acatatggct 60
tggcattgct tatagtgacc ttgtgttagc tcttagccag ntttgcctgg ccagccagcc 120
agctattctt gacttcacta tggtcatcag ggcctaatgt ctccttaatg ataaccttgt 180
ctcattcctg tcatgttaat g 201
<210> 305
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 305
ttctgttctt ttcatattat caacattttt ataatctgca ttttttcata ttgaaagaaa 60
ataaatttat ttaaaaagag aaatggggaa atactaaaat naaaacattt taattgattg 120
ttattaataa caacattatc taggaacagt aaaaattatg aaaggacaaa aaatagctga 180
agaggtaaat caatttagaa a 201
<210> 306
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 306
ctgagcagtt aactcctaag tatgagtaaa acaaggtgaa tatacagaac ccagatccag 60
acatgtggtg gagtcatttt aaagaagaaa atcctgtctt ntgggcaagg tatagacacc 120
cagaactccc cagagcccca gggtttttct tttgttagga gaaaagtatg tttctggttt 180
aatctctcta attaaatagc a 201
<210> 307
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 307
attttgaaga cgaaaagcat tactggatta aaacaaacaa gtaacaatca agatataatg 60
acaatcttct aaacaatatc attatgaatc tgaggaataa ntggtcaaaa taacaacaga 120
aaaaaaataa acttattgga aacaaagaga aaaataagtt ccaagaattt tactgcatta 180
gcaatggggg aataagagac a 201
<210> 308
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 308
tttaaataac ttgctcaagg ttatacggtt aaggaacggt tgagcagaat ttttacccgg 60
attagaatgt agaaagtttc caagagcaag agaccatcac ntatcctaat agtaagaaaa 120
aattaaagaa aaatttaaaa attataattt ttggccaggc atggtggctc acacctgtaa 180
tcccaggact ttgggaggcc g 201
<210> 309
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 309
atatctcaaa ggtaacaaat ttaggctgca aaactgcatg aggtcaagct ggtgtttcca 60
gatgttcact catgatattt tccccttcat ctcagtccca nattttgtgc tagctgattt 120
ctcctgcagt agtcctactt gagtgtggca gagattattt ctggatcact gttatgcaca 180
ctttagtttt atgaagtaaa g 201
<210> 310
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 310
atttgctgca gtgaaggagc cagtttttcc ataaatggct aacaggaatt tgatgaagtg 60
tttgcaacat taaatgtgtt gtgggtcacg ttgtaactta nattgttccc cagcctccac 120
ttttccttgt ttcctaacca acctccatcc cgccccacat gccacattca tccaggcctt 180
caataggtct gctgtcagtt c 201
<210> 311
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 311
catatacatg tatgcataca aaatatggaa aaagtctaaa aggacaaata tgtatctggc 60
ccatatatat atataagagt acaagagaca atgccaactt ncagagattt aggaaactca 120
aaatcattat gctaagtaaa agaatccaaa cataaaaaac tttataatat attattttac 180
ttatttgaaa atttagaaaa g 201
<210> 312
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 312
aacattcttg tgtgtttcta tctttttttt cttttaatgt aacaggagtt acagaaaagc 60
tctgtttacc ttctttcttt tatgaaatca tggcaatgac nttagggcaa aaatattgga 120
attcattgct ggaggactgc ttgagatggc atgattgatt agtacaccgt ccaccctcta 180
tctcttttca gatcacatct a 201
<210> 313
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 313
gttattgaag tagaatctct caaacatatt agtttcagat gatttcactc tcaaaaaatt 60
atttgatatg gaaaggggta aatattgtga tcgttaatga ngttcaagaa tttgagacta 120
gacaagattt tggaaccaaa ggaaaatatt aaaatatcct tgtttagttt taaaataagt 180
aatctgtcag agaaataact t 201
<210> 314
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 314
ctgatgctag caaagatctt aatattctta tggctggtga tttaacatga gattgaataa 60
aaaggatcac agcctctaac tttaagttca ttattaagac nccctgatct tcaccacttt 120
agagattttt tttttgttgc tagagtcacc agctttgtct tttcaaataa aaacttctcc 180
catttatgtt ctatgacttc t 201
<210> 315
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 315
tttttgatgt gatcttgtga tctagacact gttcctgact tatcgtctca gtcctcccta 60
taaattgagt ccacactgtt cctgttggaa agacattcat ntatatcaaa tgaacacttc 120
aataagatgt tcccatttca ttttcagctg atttaaacca gcagctgggc tccaatttgc 180
aagttgaatt tgcctgctct a 201
<210> 316
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 316
gaagtagtta atggcttgaa agctaagaag aggtataaag aaatggcata caagacaaag 60
tgggaagttt catgattcaa ggagagtaaa actaatgttg natttttgga gtatgtttcc 120
agtagtcaaa aagacttgtt acctaattat ttcctttttc ttcaagaagt aggaaataag 180
gtcgtttgtc ctttattcaa c 201
<210> 317
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 317
tctagaatta ttgctgcaaa gatccggtta tcctcacagg gagtgagtga aaaaaagtgg 60
gaagaaacta acttaattct aagaaatgag aggattacag ntcccagaag ataatcaagt 120
gcttcaagac agttgattaa gccaaattat atgtggtaga gaaagatttg tggagcagtt 180
tcagaatata tacacatgtc t 201
<210> 318
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 318
atctggccat tatccatttg cgtattcagg ttcccatacc tgctgtccat cattttctca 60
cattctggaa aaacacatgc cttcacttct gcgataccac naccctcttg ggcatactta 120
tgatcctttt ttaccttctc cttcatgggg gaatcctttc tctgcctatt aatttaattt 180
tgctgttagc caaatggctc a 201
<210> 319
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 319
gtacttcctt aaaaatcctg aaagtaaaca agaaaaatgg ccatctcagg ttaaaatata 60
tataagaaaa atgggctgtg aagacacagt ttagctctca naaataatgg agacattctt 120
gactgttgct tatttgatta aggtggtgat gatagaaatt attttaagaa tattaataat 180
aagaagatga tggtgataaa g 201
<210> 320
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 320
aaaaaaaata cctgacatca cgtgaatttt acttgtattt gttcaacaga gtaactagat 60
ttgagcctct catttctaaa ggaagaggac aggtttttga ngaacatcct taaaaaatct 120
gacatgactc tatgaataaa cagctacatc gaggctataa ttattagggg agatacagaa 180
tcgggaagaa gtcacgcact g 201
<210> 321
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 321
aaacagcaca agataaaagt gatcattttg cacctgctgc tttccaggtg cctttaactt 60
aaatagccaa catgccagag tactatattt taaccccatc ncatctgtgt acatttcttt 120
gcaccacaac aataaaatcc tccgttactg ccaataagtt tggttctgga gttgttttca 180
ggagctcaag caccttaagg t 201
<210> 322
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 322
ttacaaggat gtgtgtgttg aatcctttcc agagctcatt gccaagagta aattttgctt 60
cttttcagga catggaatgt ctttcaataa aagctatgca ngataagtta actccttttt 120
aatattggca tcaaggaagc aaataaatta atcatattta gaaataaatg tcatttatta 180
tttttgtata gttgttaatt t 201
<210> 323
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 323
atgtgcatag ctgctatctg gtacttatat ttactaccct tccacttgat aaaattatct 60
tatatcaccc tcacgctaca gcaaagcctg ttaaatcaac ncaccctttt gtaaagtatt 120
ttgggggttc agaagcaaat gttggcttct ttaaagtaga aaagaagcag tgagaacagc 180
ataaagaatt agggacaaaa g 201
<210> 324
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 324
cacctcttac tcgtcactgt cttgtacagg ataaatggca aaccactcaa catgttatat 60
gaatcccttc tactcccccg gaatcaactc tagccctttt ntgcctgcag tttgtacatc 120
atctagttgt agtccagaca cctcacaaca tttggtgtat ttgtggctag gatgaccatc 180
ctatccactc ttctctcata t 201
<210> 325
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 325
tgaaaatcac ttagcctaaa aagtaatttc tcctgacagt gatttgttta ggatttctaa 60
atagcattga tttagccacc ttctctatag gaatatttga ntttcacaga aagacttagt 120
tgtagatata gaatgttgct aaaatatgaa actatattag ctcgttttcg aattgctgat 180
aaaggcatat ccaagtatgg g 201
<210> 326
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 326
agaggcagac catattagcc tggccaggtt accactggaa gacaaaaaag ctctctttaa 60
aggtggtttc tgcaccctgg ctaacgctat ctattgcaaa nggatcaaag cagcagtgtc 120
catcgtgctg cattcggtat tctgagatcc attctcttgt cttgtcctca ctcccccagt 180
tgctgatgat gtaggggatg g 201
<210> 327
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 327
gaaaaatgta acattaacag actagaggtt aaaataaaaa atagaaacac caaaaataag 60
gagggacaca cacatttaaa atatggtagt taaaattaaa ngtattggat ttttatttta 120
ggttaacttt aaaagtttaa cacaaggtcc cagaaagtga gactcagaga gagaggaaag 180
agtgcttgtt cgtggacaca g 201
<210> 328
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 328
acttcagtga agaaagagaa gtaaacgcta acatttgtta aaaataatta aaattatttt 60
cttatatgta aaatacatta tgctatgtta gattgtgttc ntatatattt tttgcataat 120
gatatgagaa aaactccttt atcatctcct gctatttact tgttctttta gacacagaag 180
ctgtaatagc tatgatagtg g 201
<210> 329
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 329
atgccattct gtaaacatgg tatgattgta ttaatcctct gcaaaaacag gaaaaggcat 60
gcatggtagg aaatgttccc ctgagtattt ttgctattgt ngatagtttc cctttagttg 120
tatcccaaaa agtagagaga gaaacaaact ctcgtgaacc atcacttagc ttcatcatct 180
atcaatattt tgccatattt c 201
<210> 330
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 330
aatcatgaac acaatgatcc tatcttttct gattatttgg taaaccagta aataatcatc 60
acttgttatt tgtttaccat aaaaatctgt cttccaagac ntactcagtc tccagtgcag 120
aggcctgaga agcaacacat gaaataatca tccgggtgac ccttattgtt gggcacgttt 180
gagataagta ccattctaca c 201
<210> 331
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 331
atacctgtaa gttttgcata gaaaattcag agtatcatat tattcaatcc attcattgaa 60
tgagcttata ttgaattcct actttgaaca aggttctgct nagggacaag tcattgtcct 120
tataaaggct taagtaaaag acattggctc agaaactgta tgttgtctag gaaccgtgac 180
ccactgactc acttttcttt t 201
<210> 332
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 332
atgggcttaa agaggcctca ggaaccagag aatgtgaatt cagcatcttg cacaaaaatc 60
tgcaattaaa tgtttggtgc agatcctcca taatatctac ncaatgaatg cttaaaaatg 120
ctcaacaaac tagatgtgaa tctttggaga ggtcaatgtg gacaaatatg taaattgcca 180
gggagcagga atgttgtctg a 201
<210> 333
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 333
tttagtcttc acttaaaatc aaagaaacat tacctagcta aaaatatcag tccagtcagc 60
cataaatatg caaatacgta tgtgtgtgta tgtgtgcata natgactcaa atacacacat 120
gtatgactct ataaacacct gcacatttat taacattaat tactttctaa catctgaagg 180
ttttattaaa aattagaatt a 201
<210> 334
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 334
aacatcacta aaggaattca gtttggggat ttctttccat ttaagtattt aaaatttgtt 60
ctttaatgta gcttcttctc cagcccctta aaattaacca natcacagaa tgatttctga 120
aaataaggtg gtaccaaaat ctgaaattta aaaacacaat ttcattgttg aaaaattcag 180
cactgtgatt gtgcctgctt t 201
<210> 335
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 335
acaggaaaaa tgtgatttcc acaagtgatc ctagcttttc acactttatc cattcttttc 60
cttttgataa aatccacagg aaagatctca aatttccaca ntgatgcaat cagaaaataa 120
aatgttaaaa tgttaaatac acaaagtaaa aagtcaatgc acatgaaatc aaaaattata 180
tttatgaacg caagttgttt t 201
<210> 336
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 336
aagtaaaaaa taaaatcaaa atagaatgca aaggaaaaat tatgtcttcc ttggaaggga 60
gaacatcaca cattaatgaa ggaaaatgca aagattccag ngtgcacagc agggtaaacc 120
atagcaatgg gggaaaagag gatgtcagag gttagagctg tgagccattg attctcacaa 180
ttacaataac agtagcagtt t 201
<210> 337
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 337
gcctgggtcc acgcgatgct gatgctgtgg ctggggcttg agaacaggag tctcgctgtg 60
gtcccggcgg gctcttactt aaaggaaata tatgtgcacc naagaacatg ctatgctttt 120
attctttcat aaaggtacca ccaaaatagc ccaaagcatg agaatttaga accctatctg 180
ctccacatgg ctgttcagga a 201
<210> 338
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 338
ccacacccct tccacactca ggcagcctgg cttcaggtgt ttctgagagg agatccaggc 60
tgagtgtgtt cagggcatcc tcagagaccg cacggctctc ngggtggggg cagctggctt 120
tttggaccca ggaagttgaa cccaaagtta cactggcctc gaaatgaagg aacagcacat 180
aaatagctca ttaagaaggt c 201
<210> 339
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 339
ttttccatct tccttatctc aaggttttgt gggaggttgg agtttttttt ttttccggat 60
gggggaagtg ggggtgtacc actcagacca ggaaaacacc nagatacctg cctgggtttg 120
cagagccgtc tcacaagacc tgagtgttcc ccaaaaatca aaagtctgtg tccttagagg 180
ctgcaaactc ctcacttcac t 201
<210> 340
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 340
atgtatgaaa aagtctactc tattttacct tctagccttt gtgtgcatat ctgtcattac 60
cagggttccc aagtcagaag gtcgatcatc ctgtctttaa naactgctaa tcattctgtg 120
agtgtgtgtg tgtgtgtgtg tgtgcgtgca catgcatctc tctcaacaaa ccttatgtag 180
gctctgaagc ctcaatctag g 201
<210> 341
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 341
ctatcccttc acccattcac ctgcccaccc atttgttctt ccatcagtct tgtactaaga 60
agcatttaaa tacccagctg tgtgtcaccc gttacgaaga nctcaaagtt gaatagaaca 120
aatcatgaaa cctctcagtc cccttgttct tcatctgtag aaaaaaagct ttgattggta 180
agctctaagg ccacttttag c 201
<210> 342
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 342
gtttctgggg ctgctctgct ggcagcaggg gtgagaggtg gagtccttca ggagggacca 60
agaagggcag gccatggagg ggccgccttt gtcatcaata ntttggttgg gatgaggtca 120
ggatgggaga gtgaggacca tccgttctca ttttgttctg ttcaccaacc ctaacttcac 180
atgcactgtt cttgcagagt g 201
<210> 343
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 343
gaaattatta cattggttcc tcccccaggt gattcctaat caaaccagag ccttagaagc 60
accgacgttt tagagccagc ctctgtcgtc cctgacttgg nggacttttg ctctttcatc 120
tgaagcgcgt ctttcctctg gtgtatttgc aaaagtgccc tttgattcct tttgtctcat 180
tttctttgaa tgaatgtgct g 201
<210> 344
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 344
tataaaacac ctaacatagt acatgaaaca cagagatttt cagtgaatgg cacctgtcat 60
tattgattac atgtgcaatg agaagtgtta gatttttgcc ntctcaaaga aacccatggt 120
ctacctaatg cttgtcaaaa tcagaaaatt gtgctactac tcagatagaa ttggtaaagc 180
ctgctaagac ctcaccgttg g 201
<210> 345
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 345
ggtgcgagga ggagtttctg gttgcaacga acaaggctcc ccctacacca gcattctatc 60
tctcggcccc aagttcagct gcagcagata attttacgat ntgttgcccc aaacctctgg 120
acaagtttaa gttctgatgg gaaactgcag ccagagatgc acagggagaa cttagcttgg 180
ggaaaattga ccttaagtgc a 201
<210> 346
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 346
actttcccgt gatatgtagt atccctaaat gctccagaaa cgtgtaagat tgtttgcttt 60
agaatacact ttattggtca aatttttgag aaatcgagtc ntaacaatgt tgtggtttct 120
ctcatttttc cagcaatacc aacattggcc agtatacgat gttaacgtgt atgcttaatg 180
agccagtggc ttcatttata t 201
<210> 347
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 347
caatttatta acaatttgct gtatggatac attttttcat taatagctct atgttcagtg 60
taatgttaaa cttattaata ccatttacgt tttggttgga natgaaaaca agtctttgat 120
attttatttc cagtgtgcta aaggcaatac aattactgaa aaatattttt attctcagta 180
atgtgattca ggagaatatg c 201
<210> 348
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 348
cagtctccct tatttttgct gtgtaatctc tgcagcatgg tcatcaatca tgatgcattg 60
ggacaatgca tggggcaatc atgccatgtc accatccaca naggagctgc tgtgataaac 120
cctaagctga tgtttcccca ggtagctcat aaaatacact tatccatcat cttataacat 180
cgtaatggac acttgtgaag a 201
<210> 349
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 349
atgctatata aactcaagat ggtattagaa aggatgataa tttattgagg gatttttttc 60
accaatggat ctcagcccta attagaccca ctatctggac nctgttcaat acattcccag 120
aaacgtgtag atcaatctag atcagcatac gtgagcagat tctacaaatc agagcaaccc 180
tttctcataa gaatttacgt c 201
<210> 350
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 350
atgctgtagg acacctatca gaccccaggg aaatgatgta gcacacagga gtcatcccag 60
ttcacataga cagaacaatg ttactctgga agatcagtgt ntgaaaattg tggatgcttt 120
agtcttagca ctcttcatac gacagcccat cctttgcata acatgtaaga gccatttcaa 180
ttcagccatt ctctctcatg c 201
<210> 351
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 351
aagcattaaa aaattgcatt aagaattgcc tttccctccc caccagaaga atggaggaga 60
aataacattt attgaatatc taacacataa tagggtgtta nggcacttct acttgtaatg 120
tctacatttg tttgtcatat ctcatttata tctcatttaa ttctagatga atttctcata 180
tattttccat taggtacttc t 201
<210> 352
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 352
actattcctg tcaaatgtac aaaaagcaca tgtttactga ctgtaagtct gtacaaatat 60
ttttaattca tgaagagtag catgtaaata tcacacctat ncaatactat tttaccaaag 120
tatgcaatta gtgagaatcc tagtatgcta ttgtgtgctt tgcaagacag acatcttgga 180
atttgaaagt aacaaccagc t 201
<210> 353
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 353
tccatgattt atgcttaatt ttgtaatgaa atatttacat catgatctca agcagtaatt 60
taattgtaca ttcagtaccg tgtgggattc cggagcaggc natgtgcttg ctcattatct 120
ctagtgatct gtttgtgtgt gggctgtgta cctatgcttc atcccgtcat ttgtccagca 180
tccttgtatt ttctattttc t 201
<210> 354
<211> 201
<212> DNA
<213> Homo sapiens
<400> 354
gtctggaatt tcccagtaac ctcaggaaat ttaatggttt tttttaacag gattaagtgc 60
agacacggca ttcacctaaa tataaaattt agatttaaca nctgttcaaa agtggggtca 120
cagaaagtaa atgctatcca ttttgtaata atatgacaaa aatttttcag aagaaggggg 180
aggcaaataa ggataagaat a 201
<210> 355
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 355
accttcttaa gtttccttaa atagtgatgt aagatattcc acagaaaacc gacaaaatgc 60
atctaactta gcaaagaata cagatctgca atccaacctc ntttatcatt gagcacttgg 120
aagcacaggg caattatttt taaagctata tcaaaactct tcgtgagaaa agcaaccatt 180
gttttagagg tggaattgta a 201
<210> 356
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 356
tatcagaaaa aaaatcagtc atgtggaaca gtgcacagcc tcaaatttta gatatgaatt 60
ctgaatctta attcagaaag cctgatactc atataactcc nactgtgtaa actttctgac 120
cttcagatga agcctcacta atgttttaca cttattcgag aaagcactgg aaagagaaac 180
agtgtagact tgcttccccg a 201
<210> 357
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 357
agaataatca caatttagga gaagctcttc ataaatacag aaaaatcagc tagaagttaa 60
tacactgcca tggaaaatgg catgcatttt gaggtcagac ngaattattt tgaaagtgta 120
tttctgcgtc tctttttttg cctgtttgaa tatgatttat taagcagctc atttttactc 180
actacatttt gaaagtttta t 201
<210> 358
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 358
ggagtataaa agatacactg cttaaaattc ggaccacaat atattaatca agctgaataa 60
gatttactta gaagtcaaag gcacataaaa actaactggg ntatagttta attgttgatt 120
tgtatatttt atgttaaagt atatcttaaa gaaatcaaat attcttaatt tacccagtga 180
cattaaaatg aaaaatactg t 201
<210> 359
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 359
caaaggcagg gccctcccaa gtaagcggtc ctgtgaggac atactgctaa atacctacca 60
gccttgctgc acaaagagca gcttgtcatc tgtctcctca ngggatgtcc acaaagaaaa 120
cacattcaca tcctggcatt gaaagttctc agcaattgtc ctaaagtggc ggcctccaag 180
ggacaagctt ctgcctatat a 201
<210> 360
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 360
cttcttctag agaaagccac tctatttgga aatgtcagat aaaaatacat gtacgttata 60
aggctatcac ctattttcag cgatgttttt tcaagctctc ncttttcctt tctttctttc 120
tttttcctcc ttctgtttgc tgttcccagt agcttctggg agcttcctca cccaagagga 180
ccaggctcat cagatcacaa a 201
<210> 361
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 361
tgacattcaa ggtgattcat atcagatcag taaagagatc acaattttat gctaaaggga 60
aaagttccta atgttagagg atttttgaga atgaactgag ntgacagttg tagaggtagc 120
tgggtccctt tgggggtata agaatcattc cagaatttat aaattgcagg gcataagcag 180
tcagatattc tgtctgcgcc t 201
<210> 362
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 362
tgacattcaa ggtgattcat atcagatcag taaagagatc acaattttat gctaaaggga 60
aaagttccta atgttagagg atttttgaga atgaactgag ntgacagttg tagaggtagc 120
tgggtccctt tgggggtata agaatcattc cagaatttat aaattgcagg gcataagcag 180
tcagatattc tgtctgcgcc t 201
<210> 363
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 363
aggatttggt taaaactgtt taagtggagt atgcaattgg tatagattag ggaaaataag 60
aaaattatgc ttttccttgc ctgtgttcct ctagctaact ngggttttag gcagaaaaga 120
agctaatggt tgccatatcc tggacagtga tttgctactg ccattccttc ttgggcacgt 180
caaaaatgct caagtctttc t 201
<210> 364
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 364
ggattcaata atttgcttgg acttaaccgg aaaattcagt caagagggtc taaactaaaa 60
aaaaaaaaaa gtggtatatt aaaatttggc cagcactcct naatattgat gaaacacctg 120
agtgggcagt ataggtaaaa ggggtcatag actatgagat aatttgtaca cttcatgggg 180
cttgataata tgcatgactg t 201
<210> 365
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 365
ttatgtaaca tcaggcaaat tatttagatt gtctggatat gttcattcag acaaatagag 60
agacagagaa aactaaatga aatggcacag tttgcaaatc ntgtttcctg tttgaggatt 120
atttgtcaga ttgactattg atacatatat catggaaaaa agtatgtaaa atggctgttg 180
caaataatgg tttaaaataa a 201
<210> 366
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 366
gctaagcagc cagttttagg gattagtggc tttgtggagg agatgagcac gaagaaagaa 60
gacagtataa ggtaagggaa ccaagaaaaa tcgactgaac nattataatc tcagcccaat 120
tactctttgt tgactgtgga atcctgacga aatgtgtgtt agccagatgt tagtgatcat 180
gcaaaacact gaaagtggtc a 201
<210> 367
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 367
tgactgataa ccattaacac cctaaatcac agtggtttat ggtattaaac ccagcaaaga 60
acaaggacct aagagagtca cctgacaaat ttccatgaga ngagagataa ggaacattat 120
gggccttgta gcaaagtctt tatttagagt actccagcat ggagagctgc tcagccaagg 180
gatgggtatg aagagcccag g 201
<210> 368
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 368
caaaagcagg aatatatagg taagtcctta atatgataaa atatagaaga aacgttcgtt 60
tctaattatg agaaacacaa cagaaagtct taaaaaaatg ngattagata aatgtcgtgt 120
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatac caaaccaaaa gtgagaatca 180
tgcttagtgg caaatagtag a 201
<210> 369
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 369
tttgtgcaaa gccctcagct cagagcccat gggacatagg tagggtgggc tcagtcatgt 60
ctgccactgg tatcagactt cacttggaga tttggagccc nggttcagta gggcaggagg 120
agggtgtggg agctctgtgg cctgagattt ctatctttac ctctttcctt cacctacaca 180
ttccatcctg cagtgggtag c 201
<210> 370
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 370
cccccctgac aaaaaaaaaa gcttgtggac agaacccacc catggaagag cagagctagg 60
accctgataa aaaccatgcc tgtaactgaa actactacta nacttcttat taagggagat 120
tataaaattg tagattattt taagaaactg tttatgccaa tttgagtcag gtttttgctt 180
tgtttttttt ctttttaacc t 201
<210> 371
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 371
attcctttcc tctctgtaga tattgcttgt ccccatgact catattgaag gctagaatgc 60
tggttagtgc ttcatccggt ctgcagcatt tgcaaatgag naaaataatc ccaaagagca 120
acttgtccaa ttatatcagc atatcattga aaggtaaatg tgattattat gtttttggta 180
taatgtataa agtacagcag c 201
<210> 372
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 372
agatcgtgcc actgcactcc agcctgggtg acagagcgaa actccatctc aatgaaaaaa 60
aagaaaaatt catgcatttg gtgaaaagcc tgacccaatt ngtttaggca aaaagactca 120
cctccctgtg cctcctgggg taggtggggc tccaacaaag ttaccaggct ctgttgttag 180
gtttacactt ctcagggccc c 201
<210> 373
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 373
gcagagacag ctcatgacag ggactaagga gaaactttga aatttatcct gataaccagt 60
ggaggatttt gagtgaagct aaaagacttg atcaaattag ngctttagga aaacaaaacc 120
tttgttggct ttccattaaa tatggcagca tcaacacccc aacaaaactc tccttccttt 180
tctatctcct ctacacgaac a 201
<210> 374
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 374
caaaagctga tattttgaca ataatagttc aacttcttgg ttctgatgaa aacaaaaaga 60
aattctaagg actaataatc ttctttataa atgagataag nggcagacta tagatacagg 120
ggagatttaa aaactttcaa acatgtaaat ctttatagat ttacttgaaa ataatataat 180
agataaacag ttttccagga a 201
<210> 375
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 375
gtatctccct aaagagtcaa cagaggctga atggaccact gcttttctta agtcaatgcc 60
cagtgtcttc cccgggccac gggggttttt gtgctttgtg ntgaaagcta ttgctgagtc 120
ctattcaggg tggaggctca gtcctggcca gtggcctggg cagaagttga ggttctttaa 180
ctcctcagac gcccttgagg a 201
<210> 376
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 376
taaaatgtcc atcttactat ggatgatggg cacaaacttg gaagtcattg atctaatcta 60
gcctcaggct tctaatgagt aacactataa gtgttctcag ngaaaaataa attaataagt 120
atataagtag agtgtacata tcactttacg tttgtgactg cgaaatcttg gggcttaagg 180
aatgatttga cgttattata t 201
<210> 377
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 377
ttcctcagtg attgtgggag aaagggatgt tgtgtttaat ctcggggtct tcatttattg 60
tacttctctg gaagaggtag gccatttaga aacacccaaa nggatatgga ggaggcaggg 120
agctgtgttg aagctctaat caactatgtg actttacttg gaaataaggt ctttaaagag 180
gtaactgagg ttaaatgaga t 201
<210> 378
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 378
accactgctt tgtcccttga tgggaccaat actgccaatg ggattagagg tgggtgagcg 60
tcagggctac ctgaccatca caccagattg ctttgtttcc ntaaaaccag cagtcgtcca 120
gtgccgatag aaaacagagc aataaaacaa gtcaaatgac tgactccact tacccacatc 180
ctttttctcc ctctttgtcc a 201
<210> 379
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 379
tgcttcttgt tgtttgccca taccaagtgc atgaccacta agactttgaa tttgctctaa 60
ccctaccggg accagtcttt ctcttcacct ccacgttgaa nttgctgtcc tttttttttt 120
ctttttttgc ctggaacatt ctttccatct ccacatgcta ccttctcatc aatcaggtct 180
aggcttgact ttcaccactt c 201
<210> 380
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 380
tggacaactg ctttttttct gcctccatgt gatccaccac aggaagattc ccattgttgt 60
gtctcacctc atagatcaga tcctcattca tgtgggcaca ngccttgttc aagtccaagt 120
ttattattcc tcttggataa tgagatctga actgctatct tctccctact tccaggacag 180
aggcccacag ttgggtagcc t 201
<210> 381
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 381
ttgcccaagc tcgtctacag ttccagggct caagcaatct gcgcacctca gcctcccaaa 60
gtgtagctct aatgtagcct tcttcaggct ttttctttct nttatgattt gcatgttaat 120
gtggtcccat tcactttcca aaatgtccta ttttctgaga tgcttggcct attcttagta 180
ttattaagga tgtatttcat t 201
<210> 382
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 382
atcagtggag aaacataact aggttagcaa ttcccatgtg tataggtagg acaaaacaaa 60
atccaaattc atgtcttttt ttgtgagtga ggcaaaaagt ntcatattta gagaacagac 120
accatcatct gcctcatctt tgacttagat atattaataa tattaataat aataatgact 180
cacattgagt gctctccata t 201
<210> 383
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 383
tatataccta aggttgatga attttattgc atataaatta taatacaatc aacttgaatt 60
ttttaagaaa tatgttacat aaataagaaa gtaaggatta nctgttatct caccactcag 120
agatattttc tggcaaaata tttttctagc catttttttt tggtttatgt acatgcagga 180
actttgtcta acacaagtgg a 201
<210> 384
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 384
agcctcatgt ttaataagat tactggacaa gaaaataagg aaagtactgt aatataatgc 60
atcctgatca cagcaaaaac aacaaaaaaa tgatggtggc ntaacaatat ttagataagt 120
ctatctatca atcttagtag taaacacaga atctaattct ggatattttt taaagaaaaa 180
aatgtaaagg ataactttaa a 201
<210> 385
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 385
tctttaatga tacttgaatt tctcctgttc atgtaataca atcattcaca gaaaatgaga 60
gcagtgaaaa ctgccatgac attttatact gagcattatg nttgcaggaa ttctgtttac 120
tgatagctgt gtggaaaata gaacccatct aatagtaagg ccaaagagat attttaaatt 180
cttgattaaa ttaaacctcc t 201
<210> 386
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 386
tcttgtcttc atcttcatac tgacctgagc ttagcagctc atcttttgtc tgattctact 60
gatttttgta aagttcaaat taggtccaat tgctacataa ntacataatc attacataat 120
ttggattgga atcattctag ttgaaagtgc tggccagaca cagcatgtgg ttgaatacct 180
tctcgtctgt ctactaacat a 201
<210> 387
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 387
tcattaaatg tttcttttta tttgtttatt ttctgtttat atttttaaaa ctctcacatt 60
tccaaccaaa ttctgtccca gctttgaagc aagagtcctg nactttacta aggcattttt 120
tctgctaaac aagaaacaaa atgtgttcaa tgaaataaag acacaagtgt gctttataat 180
atattaagga ctctgcagat t 201
<210> 388
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 388
gaaaccaagc ttgaagaaac aagcaatctg ggtctgagtt acaggtcctt cacccataat 60
gtattcattt aggctcggtt gtctcctttg aaaaatgagg ngataggagg cagtggacta 120
aaagggtttt tgtactgtag tatgtcgtca cctgagctta tttttaaggc tggcacgggg 180
agtagaacac agaaccatgt g 201
<210> 389
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 389
ataatgtcaa ttagattaag ttcacatttt gttaacccta cctgtaccct cctcctacgc 60
cactaccact caggggctaa tcattttggg tttttacagc ntttgagcca ggtagcatag 120
gggatagacc aatgtttcaa acagctttgg ctcatgtttg gattcaactt tcatgggtcc 180
taaaacctaa acacctcaag a 201
<210> 390
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 390
tactgggcca ctgaccagac tgagatccta tggattccag ctgcctattt gctttaacga 60
aaacacagct gctcttactt tttaatccct ctttactgtc ntcatttatc taagtcagtg 120
aattcatatt ttctcctttc aattgtatta tttaggagga taggttagcc atttctatta 180
ttcagggtgt taaccttcac c 201
<210> 391
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 391
tttttaaaaa ccaaattaca ccttgtggtg cagactgggt taaaaaaatt ccaaatgtca 60
acatgattct aatatgtgat gctatagggc ttatttttcc ngagtttaaa aaattatatt 120
ttctgtgctt ggcatccaca ctgtgctcta gggaaccaca ttatatctgt gtacttcact 180
gatcttcttt gtggaactac a 201
<210> 392
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 392
aggcacatac tgagaagaga atatacacct cactacttaa gtttcgcctg acttcttttt 60
ttaaataatg tcatagcaaa atgatttctc tatcttgatt naaaaccagg aaaagaaaaa 120
aaaatctcca gcaagcaaat ctgtccagtg agatgcacta ccagcataag ttcacagacc 180
agttctgtag ttatagattg c 201
<210> 393
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 393
gagttcttaa ataggccacc aagaccacca ccaccacccc attccccggc tgaatggctt 60
tgtatacatt atttatataa ggataatgct agtttttttc ngagagtaga aaaatgggat 120
taatgtgaag atcaacactg aagctatttt catgagctcc tggtatatat aaaccacgtt 180
tatggcaatt actttagaaa t 201
<210> 394
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 394
agtcaccaca gttgttcagg agcagctcaa taacacaatt agtgcagctt tgtttttgaa 60
tattatataa taagttggag aggctaagtg atattttcca nagacttcag catttgttca 120
ataacttacg aaaattctat ttggtctcac taagtgaaat agaagaaaaa tatttttacc 180
ttcaaatttt agctttgttt a 201
<210> 395
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 395
ttgctagtgt gttttggtgg ttgtgtcttg ttttcccctc cacttctgac ttgctgctct 60
ttaagtttgg gttgccagaa gagacaggtg gtgcatgaag nttacttaaa acagtgccaa 120
ttttagctct gcagcaaaca tgggtcaaat caagtggaaa ctgatgttag gatgggagag 180
aagttgagag ttagaaatgg g 201
<210> 396
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 396
ataactggaa attccagatg aatttaggaa aaactagaag caactaagaa atctcagaac 60
caatgtgaaa tgtcaccttt tcaaagtgaa atgttttatt nggatgctgg aagatttcat 120
gctcaatggt caggcaggga tgcttttggt gaaatgaaag tccaaggaga caaaatagac 180
ttaggattgg ttttataaag g 201
<210> 397
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 397
atggtttagg ggatgagagt gtatgaatag attttataca gctccatttt ttgagttata 60
tatccattga aagagaactt gctctgtaaa atccctgtaa ncaatgaact gtttatttta 120
gaatgagact ctagggaata atctcataag aaacacatct tgcttttgta gaaaacccaa 180
gaggatagta ttcattaagc a 201
<210> 398
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 398
ttcttttggt tacactttaa cattatttca attatggtca gtgtaaaagt agattcaaaa 60
gggtaaaaaa tacagcttaa atgtctgcaa gaccttgttc ntaacattca tatgtcaaaa 120
actgtatctc cctatagttt gagtaacacg ttaacctact taccaccctg agttttccca 180
gacgcaagga ttttttagat t 201
<210> 399
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 399
atggttttct tcaaacaaga cataagataa actttgagaa taaaaaaatt cttgagaaaa 60
attgctaaca gacatgttaa aaggtcttta gaagtgtcag naaaattgag aaatgtccag 120
aaaatagagc aaaagtaaaa acagacagga ctttgagaat ttttatgttc agaaagactg 180
tcaatggagt gtgaagattt a 201
<210> 400
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 400
aactctaaaa ttgctttcaa aataacaatt tattccgaat tgtttttctt gttaataagt 60
ttttttgatg cttataaaaa tattttatga taaatgttga naagggtaca tttctagtgt 120
gacttcttca tgatttgtta ctcttccacc ccaataagaa attaaactct aatttcctaa 180
taatctctat cagctcttta t 201
<210> 401
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 401
gtttttactg taccctcaca tactgtgtct gtgtgcacag tgactggcac tgtttgcctc 60
tctgcagatt gactcatgag gggtggaggt cctatacaca ngatggaatg tgtgccaagg 120
ctcaatctcc atcgtccaga tttggttgtt aaatgactca acaaaattat ttacccatat 180
attggaccct atgctatgtt c 201
<210> 402
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 402
catctatttt ttaggaaaag aatatgacat tattatacaa ttataattaa gatggatata 60
aatgaactcc tgaattcttt atgtcattca ctgcaagcca ncacttactt gacacaatgg 120
cccaattttt ttattaatta aacaatgtgc ttgctaacag gatgggagac agttttcatc 180
atgatatttc taggatggct g 201
<210> 403
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 403
cttgtagttg tgtagactgt ccttacatga aagcaaagct taggctgaac acctgcctca 60
agtataagca aaagtttgca ttattttatt cgagtggaaa ntttaccgtc tttgccattt 120
actttttgga gacaccagaa gagaaatatt tattacatgt aagaagaaaa ttttgtctgg 180
caaaatggtc tttactagca c 201
<210> 404
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 404
cagtttggaa gctctatatg atgacattta atgccaaaca attgagttat aaaacaaaaa 60
taaaaatatt ttaggaaatt aaaatgagtg cttttgtaag nctgtattat ccaagagaaa 120
aagaatgaac aaaataagtt acctgatgat tgaaataaag tagctattgg tttagtggac 180
atagtaaaaa agaaattaag a 201
<210> 405
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 405
cttatgtaac caaataccat ctgtacccca ataacctatg gaaaaaaatt tttcagaaaa 60
aaaaatgaaa gctccctcaa ggattcagag caactagatt ntggaaacac aagttaaaaa 120
ccttgaaatc caggcctgaa agagtgaggt caagggacag agtggggaga gagcaaaggt 180
gtcccctgca acaccaccac c 201
<210> 406
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 406
tttattgacg atacatggag ttaatgaatt tctacaacaa ttaagaatag cataatcttt 60
ttatagtctt actcttaata tgtgattttt ccaatgaaac natttaatta ttatttcatt 120
tatattaatt ttatttgtat ttaggtataa tgtacaattt atttatagac tctaagccta 180
agaaatacta caatatctga a 201
<210> 407
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 407
ctctggattg catatgcctt cacagagtca tattgtatcc gggacatttt tagcatcttc 60
tttggtggat tttgtcctta caggagaagg atgctgaacc ntcagatatc aggccagcat 120
tcccaaaaga aagaaggaag aatggtgaaa ggcaaaggat caaagaaata ggtttgtaac 180
ttttttaaga gctttccttg a 201
<210> 408
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 408
gctcactgca gcttccaacc ctcttgcctt agccttccaa gtacgtggga ctacaggctt 60
gagccactgt ttccagctag catatggttt tctaaccaat ntttaacttc agtttaatgt 120
tgtaaaccat actaaattca gagtattctt aatgcaatgg gaaatattaa tctactaatc 180
aatacccagc ttccctgcca t 201
<210> 409
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 409
atatggtttg actattgtcc cttagtatat tcaatatttc aggcacttgc taagaacttt 60
gaggtggggg aaaatgataa gttgaaaaga gcaggaggga natatgttaa ttgtagctca 120
acatacctga ctttaacaaa ttaaattata tatgttagtt ttatgattgt ctccagaaaa 180
tttcaacagt ttttatgtga g 201
<210> 410
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 410
atgaatgtag tttatacaat gagctccacg acgcgaactc caaggttagg cagtgcaggg 60
cctgagcaga tctttcacca caggaacaaa cattttttct ntctcagtag gtaaaacagg 120
gccctgtctg ctgggcagct cacttccaat agggagaaaa gagaggaagg gccctgaaca 180
cacatgctaa ttctccccct t 201
<210> 411
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 411
ttacttatat ttctaagaat caagagataa aagttggaaa agccagattt ttgaaataat 60
ttgcatattt ctctacgatc ttgtattcat catatgcaga ngtattagct atccatcatt 120
ctccaaagat ctgcacacat ttaagtcgat gcacttttaa ttttactact gtgaattcaa 180
actatccttt tgaatgctac t 201
<210> 412
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 412
ttgttgcagg agctcaccat gtagcagtaa tccctttgta agaacaagga agccatgcac 60
ctccagctgt gatagaaata ggattggaga agagttcctc ngccagctca ccttttcatt 120
gttagcatgc catttattat aataaattac tttaagaggc acattttaca gtatcacttc 180
tgcttgtttt acttgatctt c 201
<210> 413
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 413
ttcctgtgcc ataaaaatgt atggatttca ttgttttaat atgccatatt tctgagaaac 60
acagtgtact taggttccta gaacagaaat gatcattagt ntgagtctaa tttagttccc 120
tgctaaaggt gataaaggca gctcatttat tcttcctagt aaagaagtcc ttttattgtt 180
tcaaagtctt ctcatgatct t 201
<210> 414
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 414
ttcctcacag ctctgagacc aacagggatg ccatcttggc tcctaaaaga aggaaaagct 60
gtgattctat ttcagaatct tttgctgaaa cttgctcaaa ncagtctcca tttgtaaaat 120
gtcattaaaa taatcttgtt tgcattaaat aatgatatca gaaagagcat agctattcat 180
agtacaggct tcaggtataa t 201
<210> 415
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 415
tgaatgtgac gatcttttac tatgttgtag caaagagttc agatctaaag ataaaacttc 60
ttcaagacaa aaaaccagtg tcctgactgc aaaagagagg nagaatctgc ttccagctac 120
taaacaaaag agaggaagtc ccagttctgt tttattaaaa gactttttat ccacaaaata 180
ctgcagaatt aatataaatg g 201
<210> 416
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 416
ccacacactg ttctaacagt actactctta ggcctaggca cccctgtggg gcaaagcatg 60
tgtggggcaa gcggccgtgc cctatcagag cctgcacaaa ncctcctcaa atccagcacc 120
acccctgcct tcttgcccat cctccagacc ttgctactct ctccccaaat gaccctaagc 180
cactttcagt tccagcatgg c 201
<210> 417
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 417
attgaattga attagatcta ccccctcttg atcttggcat ttttcaaagt catgaataaa 60
gcactttgct ggggcagaat gagatttctg ctttccaaac ntgacttgtg aagggctaga 120
agacaacatg ccaggattaa catcatattt aagaagtcta cttattattg ttcgcatttc 180
ctgtgtcatg gatttagcag t 201
<210> 418
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 418
tcccatgact atttgtgggc aagttaactt ttttccaggt tttattttaa tgaaaggatc 60
ccatcctggc tttctgatac caaattttat cccatcgctg ncatcaaaac tccagttctt 120
ggatttatat atggttcaaa gaccttggca ggtagccaca gggtttcaaa tattaccttt 180
aagtctgtgg gttttctttt t 201
<210> 419
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 419
acatgaacta cctgtgtatg ggtccttgtt caggagtcaa gaaagaggca catgcagatt 60
atctttgctg gtggcattct gttgcatgga catatcggga natgagggag cagggaaggt 120
tgtctcagca gtcaagaact tactctagtc tcagtttttc taggactgga ctatgcaaga 180
agtctattaa ggaacacaaa a 201
<210> 420
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 420
ctaaaatggc atgcacataa aatattatta agaataaaag atgagaaaag gcttctggac 60
ttgaatttga ggagacagat catcactgac tttcaaataa natttcagtc aaatggtgtc 120
tttctccatg cctattttgc ttttagtacc acagaaaatc tgcattgcac catatcaaaa 180
gaacaaaaga ataactgatt c 201
<210> 421
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 421
gacccttgtg aagtgccata gacgtggatt ggacaggaca accactgccc agccccagcc 60
aaacttcaat tctaatgtga gataaaaact aagcaggtga ncaggctcac accgggggtc 120
agacaaaggg tgcagagttt tgaagaaaat gggggctaag atgggggatt atacgcagca 180
cccatttctc tggaagcctc t 201
<210> 422
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 422
ctaaatagtc agttctggaa atgactccag tggccatgaa atttagactt gagcaaggct 60
catcaaggct gtgttttacg agaggatcag aggatctgag nctggcatca gcacatgagc 120
atggctgggc aatgttcccc ttttgtactc cctgcttgaa gatacagtga agtagtctgt 180
gctttagcga cagagaaaac a 201
<210> 423
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 423
gttaacactt tgaaacgcag tacagtggtt tgaccatcag cagcaatgtc agctgtgacc 60
atcggggtga gagatggtag cagattcaga gacaagatta ncccaaaatg ggaagaatgg 120
gattttcgag aaggtgcctg gcaaggctgg tccgccaaag gctcttcttt ttgtttgttt 180
gtttgtttgt tgttattgtt g 201
<210> 424
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 424
caggtggcaa aaagaaagga gaaactggaa agagagaatg tgtgtgtgag tggagagttg 60
aacttctttt tcttgtgctg gcttatcaca tctgtccatt nctcaggctg caaaactcac 120
cagagttaac agagaagcct tctcttaggc aagttccctc aagttacgta agatagagca 180
aagcttttta tttacttccc c 201
<210> 425
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 425
gctctataaa acaccttcta ccagataatc cacatttact cactagtaaa taattatttt 60
cccatgttta ttaatcaagg gtatttaatt ttccattagg ngaatacagc taatattacc 120
ggaagaggtt gatggaactg cagtactaat gaagaaagcc tgacccatta gcttttatgt 180
ctcgctataa acaactacat t 201
<210> 426
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 426
tttactagct gctgaatgca gtaaggttgc tagcaacaga gcagaaagag ctaggctgtt 60
tgctaatgca cttgggctgt actgtaacta cgcaaggcag ngctagtggc ggtggagtca 120
ataaacatgc agttctctgg ctttgagggt tatttgtttt actgagccaa tatgtttttt 180
ctagttaaca tttttctgta g 201
<210> 427
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 427
tgtaactacg caaggcagtg ctagtggcgg tggagtcaat aaacatgcag ttctctggct 60
ttgagggtta tttgttttac tgagccaata tgttttttct ngttaacatt tttctgtagt 120
gttttcgcct gtgtgtgaaa ggcttgtaaa tacacttgaa ggtgctgggg aaggaaaagg 180
tattgccaac ttcatattgg t 201
<210> 428
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 428
atctgcttct ttccccgtga aacccaaaca tgcggagctt gcatgtcttt tgagatatgg 60
cagaactgaa cttaaaacct gggctttttc gggtgtgagg ncccttatct ttagtagccc 120
ccaaataact cttaaaatgg ccggaaaatc taatttcttc ttattatgac ctaccccagt 180
tttgtcacat gttttatgtt t 201
<210> 429
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 429
acaaacttat ggggtcatgc agggatggag agcaggttat attattttta gagatctgac 60
aattctgatt tataaagaaa accttaaata atctagttca ntttagatag gaaattcctg 120
gggtaagttg gggtaaggat atatgtcttc ctttatttcc tcggctctat ccaacggctt 180
gtgggatcca tttgcctcca t 201
<210> 430
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 430
aagtagcatc tgtacacact tcattttaat tgaatttggt gttcaaatag aaaataaaag 60
tgagttctat caaaagacat gaactcttag tctatatgag ncccaaaata aggctaatgc 120
ccttttcact gtttactata tgttttgagg ctatttaaaa acaggcgata ttatttctta 180
tctatgcaaa tggaacagta g 201
<210> 431
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 431
ccaggaaagg ccattggggc ccaccctgtt gagtgcagtg ggaggagaga caagcaggca 60
aagctagtat tcattcccct acaccagggg atggccaacg ntgtcctaga ctgtaagggt 120
gataatacct gtaacatcta ttcccagggt agtgggaaaa ttaggggtgc cattgttcaa 180
attatgagtg ccattgttca a 201
<210> 432
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 432
gaaaaccttc cctgtctttt cctgtcagtc aaatattcct gccaatttcc attattggaa 60
ggcagtagca catttacagt caagacactt ccctatgctt nttttagcaa ttctgtggca 120
catgtttgga atttacattt ttcgtatctc cgactttata gaagctcacc aaggaaatac 180
aaggtgccca aatagctgtc a 201
<210> 433
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 433
attatggtta atgaaatctc tggtgccaag agaaacagag taaaatgcac ttaaggcata 60
tagccaactc cagccccagc agctgacttc ccgccatcca nacaggccac ctctggcaga 120
aggaccagcc tgaacaaaat cccactactg agtctggttc cccctagccc tccagttctc 180
tcagcctcac acctcctttc c 201
<210> 434
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 434
ttaaagaact tgaaccctgt gggaaaagca ctgcaggaga agtgtaagta ttgggtgatg 60
gttgaggtca gccaagcaca gcatcatggt atcaggaaat nagcaactga gacttcacat 120
gctaagactg catgacaaaa tgagaagata gatggcccat gtttggtggt gaagggggtg 180
aagttagtgt ttataataca a 201
<210> 435
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 435
gcctttcagc tcctaccaat agagaagaag agattttgag ggccacaact gacgtagagg 60
aaaagtggtc tctgggcagg ggggtctttc caataaggct nggaaaacag ggtttcaccc 120
acacacacca tgttgtaaaa aggtgccatg ttttgcttct ctgtttccca accctacccc 180
atccccagcc atctttcgtt g 201
<210> 436
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 436
gctgaggctg ggagcttaca tcttcattaa cccacagaaa cggctctgga ataaaatgct 60
ggggtgggcg ctccttaacg tcaacatctg tgaggacgag nccccctcct tctaactccg 120
tgtgccacac tttgcccctt gctggctctg gtgctgagga agttggaaaa acaggaagga 180
aaagagcaga tcaatttcat a 201
<210> 437
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 437
gaaagaagaa ctaggtcagg gcaggcaagg acagatgccc taatgtcttg ggtgaggcca 60
cctcctggaa actagaaacc cgagtgttgg gtgcccaaat nttaaaacac aagagctccc 120
gttaaataac tctgactaga cagatgtgag tcaataggtc aaaaaggatc aagagccata 180
gagttgaata tactcagagc c 201
<210> 438
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 438
ggagtgagct accagcctgt atcaaatgtg ccctatttat ttggcaagtt ctgctgataa 60
acaaccttgt ccgctctctc ctgctgagga attcctgata ngaactgtca aacatccaca 120
tccttcctgt aatccacctc ctgtgtgaag cagagatttc ttctggaagt aaagccaacc 180
ttgccatctc ggctgccagg t 201
<210> 439
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 439
tctaataaat ctttacctat aactgccttg gtaaattcct ttacatcccg tgacactggc 60
tccggatcct tgctatcctt gacaaaagca acttcttaga nattatcaaa cacagagatt 120
aatagacata cataccctga ctacagtacc aatgcagagg aaaaggtgga ataaggattt 180
aaccctgctg caaaatacaa g 201
<210> 440
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 440
tctaataaat ctttacctat aactgccttg gtaaattcct ttacatcccg tgacactggc 60
tccggatcct tgctatcctt gacaaaagca acttcttaga nattatcaaa cacagagatt 120
aatagacata cataccctga ctacagtacc aatgcagagg aaaaggtgga ataaggattt 180
aaccctgctg caaaatacaa g 201
<210> 441
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 441
caggtgaatt cactgcccaa cctaagcact accacaccat gaatgctagt ctgttctcca 60
gcactccttc ctagttccat tctgtttctc tctgatttgt nagtttatta cttttatatt 120
taaaaaaaag tatttctacc acatacgcat gtatccttaa ataacatttg tttagtcact 180
tcaattttgt ttagtattca g 201
<210> 442
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 442
aatggccaga gagactgttg gagttttaaa aatatccctt tagaccaact tgtgcatgaa 60
acgaactgga agaacaaaga aaacaaagct ttggtaaatg ngaaaccccc tcaacctctc 120
tactactcag gtatggtttt aaaatgtcat actggaaaca gctcaagaac aaaggctgcc 180
tctacccaag taaaagaagt g 201
<210> 443
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 443
cacatcacca gaatcagatc atacagatgc attatcagta ggtcatggct tcatgcagac 60
cctgattcca ttttcagttc tgatttttgc ttgtgttcat natgattcct tcccgaactc 120
accagtacag aactcagacc ttctctatgt ttagctctac ctgagtgatg ggctgaaatg 180
atctcagtgg gactctgggc a 201
<210> 444
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 444
aaagcctata gaaaagagaa atcaatggcc acaccaagaa tttggtctaa ctgggtataa 60
atggagccat ttacctaaac atgagtgaag tgcagggtga ntgtgccgtc ggtggaactt 120
attgaattat tttattataa ggattgtggc agaacagtaa agatgttggc cacgctcctt 180
caagtctcaa gctcactgga t 201
<210> 445
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 445
acgttttgaa aatacatgta tgttgatatt tatatattta atacattgct ccatagtatt 60
atctaatttt ctaccagaac cacctggaaa tatgcactct naaagcatac ggaaaccgaa 120
taagtgagaa ggaaaatcaa ttcagtgtca cctaatcttt cactataaag agtaaagtga 180
gttatattta atatacaata t 201
<210> 446
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 446
aggaatcttg ccaaacctgt tctataaaca gtgaagagtc acatttgcca gctctaggcc 60
tttaaatatc cttcccttga tatggataaa atgtttttaa ngttgtccta tggagatgaa 120
taggaatgat gaaattatct gcagatttag catcaatttg caaaaacaaa gtattggaat 180
gtttttgctg gtcatgtatc c 201
<210> 447
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 447
aaacttgcta cacatgtttt aaaggacttc aactcctttt ggctgaaaat tctggaagaa 60
agaaattatt ggcataacca tgaccatcca gaaaacgttg ntgatgcaat ggctcatgca 120
atttggaata ttttctagtg gtccctgttg actaatttga tcttactaag taattcaata 180
ccacttgaac atattgtagt g 201
<210> 448
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 448
gttataagat ggttttataa ttttacattt ttattttata ctatttctta tatttattta 60
tgaagggata attcttctgc cttcagttta gtttaaacct ngttttgctt atgacatata 120
atacagtgtt atctctaaat gatttactga tttgtctttt taaaaatatt tctaaccttt 180
atataagaaa caaaaataaa t 201
<210> 449
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 449
taaccccagt tttatagttt aacattttct ttttctaccc tattccgtgg ggactggatt 60
ctctaactat tcattaatta tcaactctac taacaagcaa ngcttttcaa agtttagctt 120
ggttcttata atagtctgtt cttgtcttgc tataaagaaa tacctagact gggtaattca 180
taaagaaaat aggtttgatt g 201
<210> 450
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 450
atgctgaagg gctctaattt cttccttgat taaacttttg ctatgataat aatgaaaaat 60
tattttaatt atgagaaaac ttcatccaca aggatttgat ntctttctta ttgtgatctt 120
tattgcctct ctggatcact ccaacacgtt tttgccatgt cctagttaaa tgttttcttt 180
tcctgaaatg gaaattaacg t 201
<210> 451
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 451
aattatgtta gaccttgagg tttaaaaatg agtgagataa ccccacaatg aatgtcatcc 60
agaaaggcca aacatataat agattgcata ttaacgaatg natgttaagt gaaaagatac 120
aaatatgccc tcacatgaga ctgcataggg gaggtgttag cagcagtgaa tccatacagg 180
tatgcagcaa ctcaattata g 201
<210> 452
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 452
aaaaaaaaag aaaagaagaa aaaacagaag cagttttaag gcctgaggaa taaatacaaa 60
gacagtgtaa gaaagaagct gaagtttccc atggcttagg ngaattaaat gcattgtgtt 120
agggggctac atgtttatgc ttactccacc ccaaattcat ttatttaaat cttaactcct 180
gctctgatgg tagtaggcag t 201
<210> 453
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 453
aaccaagaga ggtcatcaat tttgtgagct tagctatgac ttagtgactt agttcacaaa 60
gtgaaagtac tgaaaaaaaa aaaagccttc agaagcgaga ncaacattgt catctagtcc 120
tataccttga tactgaatct tattataata cagttgacca ttgaacaaca tggggttgac 180
ctacacaagt tcacttacac a 201
<210> 454
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 454
ggtgaaacct tgattctatc ctacagaaag aggaactatt aaatattttt gaaaaataaa 60
aatgtaacag gacaaaaatg gtggataaaa atcaatgggt ngtaatgtgg atcacaggtt 120
acataaaaga gaggacctaa atgaagtgat tttaaaaata aacagctctt tgtgccttat 180
ttatattttt tcaagtcaaa a 201
<210> 455
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 455
gtgtgtgtgt atttgcatat gggcaactgc atatgaatgt gtacctgcat caaaattaat 60
tcctaacact gccataatct aagcagtaat tttactacta ngttttgcat cttgttgctt 120
ccacttccag actctctctt ttgcttgttt catgctagac taatcaactg ggaggggaga 180
aaggatgaaa gatgtggtat c 201
<210> 456
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 456
tctagtcctc cactcgtttg aacagtcatg catgatgctg ttaggagacc tggagatgca 60
gagtattgaa gtccagaata aaattggaag taatattgcc nttgctccaa aatacaggtt 120
gaaaaattca agaaaactca cagcattcta ctcattaata ttgctaataa cttctcatct 180
atttcgtatc ctacttcaga a 201
<210> 457
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 457
gtgcctttgg ggagctcaga ttgtcaagag atgggttaac taagcagttg atcccgtgtg 60
gcagttgtca cagtggtggg aaagatggag cagtatctta ngatctgaga aacaccacct 120
cagtgcggct agggggcagg atgtgtcaag gaagtttagt caagtatgga aatgcgacac 180
aaaggtcagg aaaagataaa g 201
<210> 458
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 458
tctgtctaag cacacaaaga atgctcagga aagacactgg taccctgaga atggccagga 60
atgagggctt gaacacagaa agactttaga gtttacactc ntagctaaag tctctcctaa 120
ccatgagtgc ctctctactg ctctcccagc actgtattta tggacagaag agctgtgctc 180
tctcctaagg ataatcagga t 201
<210> 459
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 459
caggctatca cctgtgaatc ttcacactgg gaaggttttc ctacccagtt ttaatggctg 60
ttttcagaac tattgacatt taccaagtca agggcaatct ntcttttaaa gaagtgccaa 120
aatagccttg cacttgggtc ccaaacgtgc tgggaaggtg gattaacgtt ataggaggag 180
aggaggcaca gaaagtagag g 201
<210> 460
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 460
gtgcacttta cacactttaa tgtgtgtatc ttgtacctca ataagataaa aaatatgtaa 60
tgctccagtt ttcattggtt tggccaaagt acctcatctg ncttactact gcatatagaa 120
atccaagtgc tctacaaata taaagcattt atattcgtta cctatattgc cagtgtgaag 180
taaaagattg gacagttatt t 201
<210> 461
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 461
caataactca gggcctcagg gacactgagg taattaacac ttgacagtgt gacaattcct 60
gcagaggtgt aattgcagcc ctctcatttt cagcattgca ngatccctaa ttggagatta 120
tgggcagtgg tttctggacc attctcctct cccctcttaa agtgagcaca ctttcttatc 180
agtgatttta gcagatgtcc t 201
<210> 462
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 462
aatgtgtata gcatggtttg ttattggaaa gcacattgcc atattgtgca cattttagga 60
aattgataag ttcacaggta aaagacaata acttcttccc ntttaaaaag taggaaatag 120
ctttccaatt agcaaattgc ctaaaatgtg ggcaaaacat ctgattttta aaaacagatt 180
acagatatta ggtaacagat g 201
<210> 463
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 463
gcaccggata atagctaatt tcttcatttt tatttgccta tttgtttcaa attatgttga 60
gtggtgtcaa aacaggatat tgtttgggca aacacagaag ncagttcatc tgctgctctt 120
cgtgagttcc ttgccctgct ctctctgctt gtggagatca gtgtccggtt atctacacac 180
atcatggcag gttgcttatg a 201
<210> 464
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 464
atgtttataa gctagtcttt ctgaagacaa aaacactaag caagaaggct tacagtaaga 60
aaaaacacat ttatttattc attgaataag tagcatgcac ngttccaaat agtagagatg 120
taaatcccct cactttaaat ggaacttaga ttttagtggg ggtcagggag gtgctggtgg 180
tggaggtgct ggagacacac a 201
<210> 465
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 465
cttttataag atcaccatga ctccatgtgt gaagaataga ttacagtgat ggcactgtaa 60
tttggtctat attttatgac atgtgacata gagtaaaaca nactaatcag ataaaacaag 120
gccaaaataa ctggaattat tcaaacgtta tgtcgtcaca ccaactggag aaagaaaaat 180
cacaaaaaaa gctggttgaa a 201
<210> 466
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 466
aagaggaggt gctaatggtc ccccaatatt caaggagact aaatctatga aacttcaatt 60
attaccataa ataggaccta gcattacctc tggactaatg ntacgtggaa gagttctaat 120
tactcataca tgttagataa ctaaaaacat atacatcaac agtgattatg tctatatttt 180
ctgaaatttc tacaatgagt t 201
<210> 467
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 467
ccttctcagt ctatccctgc ccacactcac ttccagaagc aatgactatt ccgatgtttc 60
tttactacca taaatgtggg ttgttgagtt ttgaaattac ngtatttata tcaagaatcg 120
gtagaatgag gtcctaacac tcaattacca atttggttct ggtttgcttc tgtagcttgt 180
tgcttctctg ttgcactgac a 201
<210> 468
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 468
caaaaaaaga gtatgagcct atctgcaggg tttttttggg gggtaaaaca gaggaagaaa 60
aaaactacca tcactaaggt ttaaaatctg gttttctcaa ntacaccctg agttcttatt 120
caacatacaa gttaatcctg tgtggctgag aacacagttg gagaagttag caaaatatac 180
tttggagtca gataaggttg t 201
<210> 469
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 469
agcaggactt ttgaatggat taaatgagaa aatatatgaa aaaactctag gtactataaa 60
acactacata aaattgtgag ttattgaaat ttttatgatg ngaagtacct tcaatgaaca 120
agattactga ggagttttca aatagttgtc taaggcttct ctgctctgtg gttagagctt 180
tgggggaagg aaggttaatt c 201
<210> 470
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 470
ttcatgcata gctgctaata gacatgaggg gcaagcacta tttttaaaaa atcacatttc 60
aggagcctca tgtgggtcat aaaacacata ttcaccttgc ntgcttccct ctgtcttcta 120
cattcaatag cacgaacata tttttgttac tctaactata aaaatgtatg tggatggttg 180
cacactgaag ttttagttta t 201
<210> 471
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 471
gcaggagatt ggaatttata tggaaaaaat ctgagttaaa gagtcttatg aagggagatc 60
tgggaaacat tctgttcatg gtgtacatac aaattgaagt nggagaaact ggtggagaac 120
attttcagaa aattccttct ttcaatgaat gtcactgaaa agagcatgaa ggttgagtgc 180
agctttgtcc cgggattcct g 201
<210> 472
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 472
gaaactttcc aagattacac agcaaacaaa ctgaggagca caagattcaa ataggccact 60
gtttttggtc aacagattgg tttagaaact gtttattgtt natttctctt agacatagtt 120
ttcactcaca ataactctgt ggtattcatg gtctttgatt ttccttttat tcatttatgt 180
ggaaattctg gcctctattt c 201
<210> 473
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 473
ctcccagtct ggttttcctc tagacaaaga ggctgcctgg ttcaacatgc ctgacagcat 60
ggttttacaa tcgtgtactt gattttcact ggcatagtca nacccataag ttctcaagct 120
cagagacttg gttcaaccat tcttttgaca gcccaccagc cacttaacat tccattattt 180
ttcctctggc acacaaactt c 201
<210> 474
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 474
tctaaaattc tttcttgtca tttatttgga ttactgattt ttgaattttc ttttcatttt 60
tgtcaaaatc atgaaagaag agattttcct cattggaaca natactttat tatgctaaaa 120
tattcctttg gagaaaccga tcactagaat cctttagtga ttctgagatt tcactgcaca 180
ttagaatcac ctggaggact t 201
<210> 475
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 475
gatattgaga tggcatttga ttagcaaaat tgtaaagtta aggtgaattc atgatccgca 60
cttaaaaatt aagatgaaaa acagatttta aaaaatgctt nctgtgtaat ggattatctc 120
aggatttggc aataacttga tatatgagac agatattgta ataattaacc ccacacaaat 180
tgaggcaatg ggcattctga g 201
<210> 476
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 476
tctgaaaatg ggaaccattt ccctcatctt tgccctgcag acacctagag atgcacatgt 60
aaatgcgtca ctccttatac acatgaaaca cgttcagtac nagcaaacag ggggaggcat 120
ctctggcaaa aacaagccct aattctccat gagtttccac ctttttttcc gtttctcttg 180
ttcttatcct ccttgtcact t 201
<210> 477
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 477
caaaatttat actataaaaa ttacaatgat taacagacag ataccatcaa tacactaata 60
cataaaacat caggaattga tacaatgtct tcatataatg ntaccacaat ctaacacaaa 120
agacctggtg ataaacaata agataatttc ttaatttttt ataataggta attacatgct 180
tgatatatat gatacctgat g 201
<210> 478
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 478
tttaacgcgg gaaaatttta cattgttgta taagacatgc ttataaattc acatgaaaac 60
ttaatactac aacttaataa gtggtgggtt tttatatacc naattgagga aatgcagtgt 120
attgtaacct atacagccct atcacaataa aattgggagc caaatggcct ttgttacaat 180
gttgattgcc tgaatttatt t 201
<210> 479
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 479
tcggaaaggc tagtaacaga gttattcatt ttttccttgt tttccttcac cactcattgt 60
tggggaaaag agaacctctg aacttaatat tacagtaagc nagtttcccc agatcacaac 120
gtaatgatgg ttaatagcaa atgctcacct attagaaagt gaccaagtga atatacactg 180
gtataataaa ctatatgtat a 201
<210> 480
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 480
ggttttaaat aaaacattta ttttaaacat ttcgtggaaa atccaatttt gatgttatgg 60
cactgacacc tagatatgtg cagctattcc ataccaaatg ntttcttccc gaatgtcaac 120
atgtcctgtg tttgtaaaag tattatttaa tataactaaa ataaaaccat catttcaaac 180
aatgaactct gagaatgcgt g 201
<210> 481
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 481
caataaaatg aagtgtgcct gtaaagggct tgagaattac atgaacacag gtcaaagaaa 60
atggaaatct ttagaaacag atgagaataa gtgggtagat nttgctatgg cttaattggt 120
tgtctcttct aaaactcatg ttaaaattca gctgtctttg taacagtgtt aaaaagtggg 180
acctcgaagg ggtgattagg c 201
<210> 482
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 482
agaagtgacc cactaatttg tatcttaagc aagaaaaatt gtttcaggcc aactgagatt 60
taattcctct atgatgcata ttcttttggt aaatagttca ncatcttgta actgtcaact 120
atttgtatgt tatatattag ctattttgac agcaactata gttctctaca taattctttt 180
tttttttaat tttttttttg t 201
<210> 483
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 483
tagcagcaac acatcacgat gccctggcta aaagctgtgt ccaactcctt atcttgtcct 60
tgctgccccc acccaggcta ttgttgcaca agtcaaggaa naataagatg ctggctcagc 120
cttagcacct tgccactgcc caccacattc agaaggccat tagagtcagg cagtgagtgg 180
gacaggtgcc taggtgggag t 201
<210> 484
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 484
atgtttagtt cttgctcata ttacatgtct cttacaggtc tatagctcta aaaatttcta 60
agtagcaccc aggataaagg cagtgccttt acctggtatt naaaggtaat gtagcaaaga 120
gaaagaaaat ataactcaga gatataccca gaaagtggaa caagttactt ttattcacat 180
tttatagaat aaaacaagtt g 201
<210> 485
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 485
aactgttgtt ttatttgcct tagtcccatc ttaaaaccag ctcaaaaatt tcactttttc 60
ccttgttgag ttctccccac attcccattg cttttcccca nttggttttt attctcactt 120
tcacctctac ttctgtacta cttaatctta ggctcaaagt caaggtctta aaaaaaaaat 180
ctgagttcac tggactaaac t 201
<210> 486
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 486
atcttttttt aatggaataa gattttggtg gaggtcaata caggctcaca ctgcagtgaa 60
atctctagaa tatcacaaca cacacaacac agtaaaataa nactaaaatt ctcaaaaatc 120
tccattcaaa tccacatgat caaaactgaa aacactgata acattaggat agaaatgtgg 180
caagacgtat cttcaaagta a 201
<210> 487
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 487
tatgggaact acaattcaag atgagatatg agtggggaca cagccaaacc atatcagatc 60
tctatacaag ggaaatattc tgcaggatga gaaatgccaa ngaataaaaa atgaaactag 120
tagtaatgta gatatttatg tccttaacaa tttttctatt ttaaaaggct caaagaaata 180
ttaaagatag gtagacattt c 201
<210> 488
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 488
ttcagtcagt gagttaaaaa aattagcaca aatgcccagt aggaacatta gacactgaat 60
gaatataagc cttgcaattt tcaatatctt cttatctaat ntgatagtat cttttcatcc 120
actggtggtt ggcataaatc tcagactata acttgggcat aaaagaggaa tccctttatt 180
ttctattacc atttaatttc t 201
<210> 489
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 489
agtaatgtaa tttagaacag gcttgaaaga atgttctcct ggtacatcat accaaactgt 60
cttttcaata aaaaagacat atggcattaa ttataagatg nttatgtgaa aggtacatgt 120
taattttcat atgaaagaac ctgcataaaa tagttttatg actactatca tcattattat 180
aatgcctcca agatactccc c 201
<210> 490
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 490
tctgtttgga gtattttcaa taaaatacca cctccaattc tctcaaaagt aattaaaaga 60
aaggtagaaa agtacttgta cctactcgaa taacattttt ngtgtcactt tataagctcg 120
tttctacatg tttttctgct ttatgtttag atgcaaaatc ttgactcttt acaagtttac 180
cattttaggg tcttctcatt g 201
<210> 491
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 491
ttcttccttt tggggagaca gagtagacat gaggaactag aagtcaatct catgagtcta 60
tgacttagtc ccttctccat gtcatcttct tatccaaatc nggcaactgc atctaacaag 120
tgacagaaaa cactcacaga agaggtagtc accgagtaaa tcatttaatc actccaagct 180
ttgatttctt cagttaaaaa a 201
<210> 492
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 492
acacaatttc tgtgaatcca tgctctgatg atttccccca tctacagact ttcagcatgt 60
ccttcaagac ttatgatgta ataagaataa agcaggaaga ntaagaacaa aaattgtgct 120
ggaaagaaat ctatgagaaa tgaatttcag gttttctgga gagttctgat tgaatgactg 180
cactatatta ttagagtagt t 201
<210> 493
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 493
ctgaacctcc caggaagata cgtctctatt attctgagaa ggctattatt gaaattagtt 60
aagaaaacca cttatctccc tattatttaa aaatctgtca ntgtaaagat ggatggcatt 120
actcagaatc agaaaatttg aattccaaca cttgattatg aaacttggta gctgtggggg 180
gcggggcaaa gatggctgac t 201
<210> 494
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 494
gggtgcactc tctgcacgtt acggtcacac agttcagagg aaattctatg ctatcttgca 60
tctgcacctc tatgtccatc ttctctttct cgacttaaga naatcagctt cctggacccc 120
ctttacctcc attcaccttt cacaactttc actcgttttg tgagacagtt caattatcac 180
tttcaggatt gtgtctgttt c 201
<210> 495
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 495
agtttttgtg taaaataatt ttttcaaatt tcagaaaaaa atatgcttat gaaagaagct 60
ttagaatgca acctgcactg ttcatgacca aacatgtatc ngtatagagg gcatgagagc 120
agaaataaac agaaataaat attcacctcc acagggtagc cctaaggatc ctatgcccag 180
ataactagct tgtgagttat t 201
<210> 496
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 496
tatttatttc tgtaaaaact cgttcaaacc catattacta ttgaggggtg ggtaaggggg 60
ctatgttaag actgcatgtc attggccacc cactcctccg nctgattcag gattggacgt 120
ccagcccaag gagcaccaag ctttaactgg ccaggaattt atacatgttt ctcaatcaat 180
aatttattcc agaagacaca g 201
<210> 497
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 497
atctttaatg ctaatgaagg tacgtccata ataagttttg ctgatcaaaa ttaattttac 60
acatagagga aataagaggc aaagcaatct ttattaaatg ncagagaatt aaatcctttg 120
aatgatgtta cagaggctgc caaggtagca tgagcaatca ctaagttgta tgattattgg 180
tttcttgggc aagaggagtg t 201
<210> 498
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 498
aaaatttctt ataaggcaca gcaaattcat atttaaagaa acaaaatagc agcttttctc 60
tctttaacat aaatttaatg tggagaccct tccttatgtt ncaaatgctg attatgggaa 120
acattgttta ttccagatga ggtagtgtga tgttatttca tccatcagag agacagcagg 180
cccctttcag agctctagga t 201
<210> 499
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 499
aaaaaaaagc agagattagt cctcattagc atgtaaaggc aattctttca acttctcaac 60
agaaaactca agaacaactc tcgatttatg gattggaact ntggatgttg gatgtgagaa 120
gactgacaaa gaacacaggg atctgatatg agagaaaaat ctgttaactt gccaatcttc 180
ccctatcttc tgtgatgctg t 201
<210> 500
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 500
gagccagaga taaactgcta cagtccagct attatgtatg gactgccttg aggttttgta 60
tgtgggttca atgtgtgtgt atgactggga ttcatctgcc naagtcatta ctagccataa 120
ataaacagga aaaaactgtt tacttactcc tctgatttcc agtcagaatt atgatgctgt 180
atcattttcc tgtgcactaa t 201
<210> 501
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 501
tggatatcca tccaggttct ctctgagtca accttgtgct ctaccttcac ggaagcattt 60
agttttcaca caggacagga aaacaaatga gtctgtgttt ntaaaggtgt agcaatagaa 120
ataaatctgt cctcgggcaa atatccctta tccttttctg tgacgtgctc ttctgtgggt 180
ttgcctgtac ttgcctttta t 201
<210> 502
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 502
tgaactattg acccactaat atatcaagag attatgttat gactaacata tatccaaagt 60
tcaatttaac tctttcttta ctggccaata ttgcagtaaa ntttctagga ctaaatcctt 120
tacttctttt tcaaggactg gttagcttta gatgttatat gaaaagtagc aaatgcataa 180
atgtctgaac attgtttata c 201
<210> 503
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 503
cagaaccaga tctaaaatct gcaccctgag gctgcaaaaa ctcagtttcc gttttgttgc 60
tacaggaaaa cagcacaagg gaagtactgg caagaagtga nactggtcag tgcatctgcc 120
atccctgggt gctgtcttgg tgagacccca tcagtcctct ccaccttgtg cactgatgct 180
gaagactccc ccctgaccag a 201
<210> 504
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 504
catgcaggaa aaagttgtga ttagttaatc tatggttctg ttcttaaaat agcaacccct 60
caagaactct attttgggaa gtgcaggcta aatagtcaag ncctggagaa agcacaacat 120
gcattagatt tcttattacc agatcttctg cattgttgct aagtgttact gtcccttaaa 180
ctgaaaaatg ttttaatgat t 201
<210> 505
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 505
ccgcaagtcc aacaacagct gtgtctgaca gaagttaagt gatttgccaa aaataaaaaa 60
ctgagaagtg acaagttaag aaacaaagac cacaagggtt ntggttaaga agtgacaact 120
taagaaacaa agaccctagg ttaatcaacc tagggttgat taacaagctt tgattaagca 180
cttactgcat gcaaagcagt g 201
<210> 506
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 506
tgctgaaaac agaaagggtg tgtctgccat gccaatccca gggaatgcat tcttttctag 60
gcagctgtcc tttctctaat ccagcgctcg tttctccaag nctatatctc tcaggttatc 120
atcaaggctt cgttcatgtt cacttaatcg cacagtgcct tcatggattt catgctcaat 180
taccatttgc taaattcttt a 201
<210> 507
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 507
agctcactag tctctgcaag gaatgttgag acagggaaaa aagtgtgtgg gtctgtatct 60
aaacaaacat atatattttt tacacttcga ctatattccc ntttctggtt ctgtctctga 120
atacaaatat atttagagat atattcatag agacatatta gtatatatgt atctaatatg 180
taaaatgatg caatttaaat t 201
<210> 508
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 508
tacccattag tgtatatcct gtaaggagta aggacgccat tctaagggtc taaaaagtga 60
gactgagcga taaggagatg tcatgaagat gtgacttgac ntgtgggttg aattactaac 120
aatggcctga agatacattt tgatatatat tatatgtgaa ttatatgtga tatatatata 180
atatatatta tatgatatat a 201
<210> 509
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 509
gatgcttaaa cagccccagt tctcaccaag aaacaccaag gcccccatgg ccacctccct 60
gttgtgtaca agctgggagg caagctattg agattcttct ncctggtaac cgctgcactg 120
gccaacttgg ctaaactagt tctagtgtag atgcatctga gatatgacat tcaaagagaa 180
ggcttgaaat acagacattc t 201
<210> 510
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 510
caaacttgta tgcctctttt tcatttaata gtgatcccaa gaaaaatgtt agtattcttt 60
cttttacaca taaggaacca tatataggta gtaagaatac nattcaggat tccaaaatcc 120
atgatctttt catgtcttga ctcagctggc attgagctgg gagtacagag atgggtgcat 180
gtcactatga gagtgtttag a 201
<210> 511
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 511
acagtgagtg gtatacagtg atttctccaa aaatgtttcc taaaaagttg tggagctgcc 60
tgtccttaca ttttgtagca attgccagat cattggctct nacagatctt gttcactttt 120
taatataata tgaaatatct gtttatagtc atttaatttc tatcaaacat taatgaaatg 180
tattactaaa agaaaatgac t 201
<210> 512
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 512
ggcagggtct ggggactact agaatatgcc actggaaaat cctaaattat ctccccatgg 60
aacactgctg gctgaagtac acacaacttg tattttcttc ngcagtagca cagatgcatc 120
tgcctatttg cccagctgct tgcagttgga agaagctaag tctacatcga gagaaacacg 180
gctattttct gcagctaagt c 201
<210> 513
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 513
acacaccact gaattaggtg actctggtgg cacctcaaag caggtcccct cctcaagtag 60
gttgtcactg cagatggacc tgaggacatt tttataagat ngtttcgggc tatcagcaag 120
actcctttcc tagcactttt tttcatcaca actgccacac tgttgatgta gatttcatgt 180
actctgttct tgtacaatgt a 201
<210> 514
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 514
gaaatctctg aagggaaaga aatgtataga agacattcat caatatccct tgattgcatt 60
tattgtttgt ggtagcagaa tccaacagtc tacaactgac nttatctgac agactcctat 120
gccctctgca catgcaattg atgcaaagta aaaactgcct ttatgttcaa aataaaataa 180
atcacctaag atgttcagat t 201
<210> 515
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 515
gaaaaatatg accagatttg taattttatc cagaatctct gcagctagaa ggtgttcagt 60
taatgcacat gtttgaatat ggtaatgtgg attaacatgt nggagacaca gagacaatcc 120
aacaaaaaca ttaatcagat ccaaaatgta catctctgct tcaaacacca gacaacaata 180
aaggcatttt aaaaggctcc a 201
<210> 516
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 516
gcagatgcat acttaaacct taacacaagt gaacctgcat tatgctttaa cacaaatgaa 60
gagtgaacca ttatttcatg cattgacaaa tactaaacac ntcggccatg cactcagcag 120
caatgtgtgg agtcttttgt ctgatcacat catatcacag ctttgtatta cagtatgtga 180
ctaacacatc tttctttctg g 201
<210> 517
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 517
aatggatgat tacagatgcc catgcagaag aatggagaga aatgggtatt aggaaaattt 60
cccatttgga cattgatgtg atagatgtat tactaaaaag ncatggcagt agtgatgggc 120
atggctaaaa gcaacataaa aatacttagt aattgctcaa ttgcaaagag ctgttgcaaa 180
agataagaat acatggtttt a 201
<210> 518
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 518
gtgctttcta cttttgcaaa tgtcctgttc tgtggagagc tgcataaacc aaatagctga 60
catgaaaaat aacttagggg aaaaggagac atatactacg ngcccagtga agcagggaga 120
aacttagggg ccatggaatt tcgagtaaga ctcacagact cacagagagg ggaaaggggt 180
ggggggtaat tcaggtcttg t 201
<210> 519
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 519
tatggctgag cattgggaca ctcattggga tcttttatgc taaaggattc taataggtga 60
tcagcaaagt gaataaccaa gcccagagaa gcaacagggg naaagaatgc tgtgaggagt 120
ctgtaagcaa atgtgcagtg gcaggaattt gcctatgaaa gtcaaggagg aggagggaag 180
ccagcaagag tggaggaaag a 201
<210> 520
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 520
tttatgcaaa attttttaaa ggagcagtta gcatgatcct ggcaggtgaa gtgaaggcat 60
gaggtgggag ttggaggaaa gtgactgata gatgaacatc nactataaag gaggcaacaa 120
aatgcttgaa tttgagaagt gtgctttgta tacatggaat gaggtctaga cataagtatt 180
ttatgatgct tcccagtaaa t 201
<210> 521
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 521
cccatagccc tttgagatta attttttagc catttctttc agattcaact gtgctttatt 60
gttcagatta agcactaaat cctgtttcct ttgatccaaa ntgactccta ttcatcagaa 120
ttctggtcct ccatccccca ggcttcatca tgtagaactt ctctcagttt ggtttgaaac 180
ccagatccta ttatcccaaa c 201
<210> 522
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 522
actgtttgcg accccacaaa ttgaaaagtg actgaggaac tatcaacaaa gagaagatat 60
caccagcaaa atttgcagct ggaaggaggc tttaaaatgt nacactttgc agactcactc 120
atctcttcat taatggcctg ggaaagggag gaaatagccc tttaatgcaa tctttgaatg 180
acatacaatt ggaagatgtc a 201
<210> 523
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 523
agccggaagc actcttagca gatccagact gtgaatgtag gtgtatcaca ggtattggaa 60
gaagagagat gctaggggca cattcagaat tctatggtga ntggagaaaa aggactggct 120
ctgagctagg tcccaaaata aaaatagtag aaacaactca atacgtacac tggaaaagtg 180
aaaattcaga tagcctgcaa g 201
<210> 524
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 524
cctcttcgga cagcgttcaa ctctcccagc cgcacttctt ccctgaatgc tttttaatct 60
ggcatgatcc acaaataaag gaaattgtgg ttttcacatc ntgatggagg ttatttttcc 120
actgtgaata ataaaagcag agtatcccat ttgtagcttc gaaaggttcc cattccaacc 180
cgcattattt attcctcagg c 201
<210> 525
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 525
ggtttcacag ttcttagaga ttcattcatt tattaactca ttcagacctt tagacacaat 60
tccttacatg tctatgccag atactgaaga tagaatggca nataccctat cctatccgcc 120
agtgaggatc ttgctatctg gtgatcattc tgggtaagag ttctttcttc agagaaggaa 180
atcaggcagc cagtcctgga t 201
<210> 526
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 526
tgaacaaagc acgacagaga agggagactg ggaatgcaca aggagaggaa gagaacacag 60
cccacacggt ctgccagatc tcgcccagct gggaagctat ntgaccagcc tggactctgt 120
cctctgaact ctccagcact gagtcaacct attgtacccc tggcttgatc ctcattagat 180
gcactgaaga tctcgcaacc a 201
<210> 527
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 527
tgaggctgga gtgttaagat aggcaagctc taagttactc aaccctctcc gaaagtcacg 60
atcagaggtg aagagccaca agaatagcgc ttggaaatgc ngcaattggg aagtcatcta 120
ccaaacatcc tcaggagagg ggtcgccttc agcagaagca cagcaacaaa acagagcacg 180
aaatgtggag tcagagaaga g 201
<210> 528
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 528
tagattatgg aacccatgca gactgcacgc ctactgtcac attggaccaa aagagaattg 60
ggatccatag aaagagggag aatggagata agacgttaag nataagacag gtactcaaaa 120
atgggaaagg ggtcagtagg ttgctgagga gatgggaaat aaagagagct ctggaaggag 180
aaaaagttaa tgagaaacaa a 201
<210> 529
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 529
gctccacttc tccatcttgt caataacagc gtctatttct gcacacaaag aaacttgttt 60
aataaagcag atataactct ttaggggttg gagtgtgtgg nttttgttgc ccccaaatca 120
gctgcataac aaaaagaaag gctggtattt taggtgacga gtgaaaaatg ggtcaggcag 180
ctctctgatt tcataggaac c 201
<210> 530
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 530
gcttttactt aattcatcat ttccaatctg ctgagggtcc catgccttgg ggctttctta 60
aaggtcaggt ctgattaggt gggaacagca agaagcaaaa ntgaggactc tggctttcct 120
gccttcgtta tctactccag tgtcctttac agaaaccgtt tacattcatt atttgtgtct 180
tcctcacatt ttgttcaatt t 201
<210> 531
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 531
aatgtgtgtc tctgagaaag ttgcttaatt ctgagtaatg gtttacttag ctttaaagtg 60
agggaggcta cttgtgaagt ttgaaatgac aaatgtgtct ntatcagtta tctgaaaaaa 120
aatggacatt accatctcag cttttggcag ctagcatgag gttggagaag gtgggttgga 180
taagcaatca gccctatcgc c 201
<210> 532
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 532
aaacaaggac aagtcttaaa gttttaagac tctaagtatt tgaactttaa acaagcctta 60
aaagttctaa gtattaggtc aagtgaaaca ataccagttt ncccaaagca tgaagagaag 120
gaaacgagac catctctaat aagaaagtga taagttggaa gaatggacag agacactgat 180
aaagatgatt cattttcttg a 201
<210> 533
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 533
tagtttcttt cctcatttat gtaatatatc ttttattaac tatttacttt gggtagtctg 60
gcctacaact gtttgacttg gtgggctttg attaacattc ntatgaccaa acagaaccag 120
tgttgaaagt gtgtgatgga atagcattcc aggtgatcga gctaaattgt gagaagctag 180
acgtgttaaa catgaaaggg a 201
<210> 534
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 534
ttcagtctag tgaagttcac caaaaaggct ttccacaatt attcagaaac tcattctaga 60
tctcttttta ctctttattg tgaactgagt ctctgagacc ntattccaat cataattcca 120
acccttagct taattaactg atgttaaata tatccatatg gaattaaatg actgtctcta 180
tgctgctata acaaaatact c 201
<210> 535
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 535
cagatacata caataatatt caaaatactt ataaggtctc actgaagcaa gattcatgga 60
ccttcactta ctaatccttg aaatagaagg tttaaaaata ntgagagcag gccgggcgtg 120
gtgactcatg cctgtaatcc cagcactttg ggaggccaag gcgggcggat cacctgaggt 180
caggagttca agaccagcct g 201
<210> 536
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 536
tccataacaa taggtagtac atttgtgagt tctaattctt taaatgctca atgtttctgc 60
aggttttacg gtgccattga agaggacttt tcacgtggga ntcctggata attatgacaa 120
tatgtttgct ataatctttt tttttttttt tttttttgag acaaggtctt actctgtttt 180
ccagcctgga atgcagtgac a 201
<210> 537
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 537
aagtttgatg taactcagca ccttctttct tttcccaaag tataataatg tagccaaatg 60
tttaatacat taatgttttg aagaatctcg gtttcacata ntgcagctta ttgccttcta 120
ctatttcttt cttctccata tcatcccgtc cagattacca acagaagctc catttctaaa 180
aatttgtctc cctatcatgc a 201
<210> 538
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 538
tccagaatca tgagcaaatg aatttctgtt tatcatgaat tacccagtct gtggtatcct 60
gttatagtag cacagaccaa actaaggtag taagagtgta ntaatacttt tccatattta 120
ctgaatccta acactccttt gttacttccc cttttgcaaa atgacctctc ccactttacg 180
aaacaaaggc attcccctta c 201
<210> 539
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 539
ctaactctga ctatagaaag agactgaaga ggagctcttt catatatata tatatgttaa 60
gtatctttta aaatgtatac cctagttctg ataactggac ntgttgactg cttaaatgct 120
ataaatgacc aatttctaag tagtcttagg atctaatatg ctgtaatgat gcctaatttt 180
ttcttcagaa aatttactga a 201
<210> 540
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 540
ttgctttttt ccttaaagtc ttagatggtt tataaaatct aaatatttta ataaacatga 60
atgcacataa ataatgcttg tacacatgta tatgcatgtc naaattagca ataaattaag 120
gatataaata attagaatga aatttaggac gaggttaaaa tctcatacat tggaattata 180
tgcttagagg accagtataa t 201
<210> 541
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 541
aacacataag aggaatggaa gaagaggaga gactattatt gtttttcaac ataaaatttg 60
atatcaaagc caaacataat tttcttgcaa aatttgatcc ngaatttaca gttatgtgaa 120
tttaagcaca gacatagtta ccaggatgct ctttatagca ctgtttcaat atattaaaac 180
atttacagca atagaaaaga t 201
<210> 542
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 542
gaggagctaa tagaggagca aggataaaca aggtatggga ttccagaagg ttgtcaaact 60
ggtacgaaaa ttcaagtttc ttaatttctg gtctaataca nacagatggg atagagatag 120
gaataggaag gggtttatgg agggaaatag gagaatatgg aggggatagg gagaggaata 180
tggaggggga cagaaaaagg g 201
<210> 543
<211> 201
<212> DNA
<213> Homo sapiens
<400> 543
gtcaatgtct tggtgttttt caatgaaaat aatttctaag tattaataaa ttatatattt 60
tttgcaattg cttagaaata taatgagtgc atggatacat ntatgaaatg gaaaaataaa 120
ttttattttg tgcagttaca gctaagctat cttattaata cagcataaat cagtaacagt 180
tataacatta caaatgttta a 201
<210> 544
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 544
gtgtctctcc cacaacatga gggaattatg ggggctataa ttcaagaaga gatttgggtg 60
gggacacagg aaaaccatat catatgtcct actaaaatgc ngtggtatct gaaattcttt 120
gttatatatt ctgcttcaga caactttgga tatattcctt ttttttaacc acattctact 180
ctattcactt tcaacataga g 201
<210> 545
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 545
aaaacatatc tgcaagataa tattctggat tatggtgccc aggacaatgc cccccatcta 60
tgtgacttat ttaccccaaa tagagtttta taaccactaa naaaactctg tcattgttca 120
tggaaaatat gcatgaaaat ttaattgatc aatacccaaa atgaagtgct ttaggtacaa 180
tgcaatgttg catgtattac t 201
<210> 546
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 546
actcaaattc ctagattggt tacagcctgg aattaaatca ccaatgtgat cacggaaatg 60
caaacactac ctgaacatta tgcaagcccc cagaggagca nctttttttt ggtaaatcct 120
gtacattgct ttcagtaagt tacaaatcct gtgccatgtt tatgcaaaca cagcagatgg 180
ctatacaaat gaattatatg t 201
<210> 547
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 547
gaggactgct gatgggatcc ttgcaaacct tttcctgtca aaattaagat tacaatttta 60
ctgcctgcat ggggtgaaga taaagggctc atgcttcctt nactaatgct agacgttcag 120
aaacagtttg aggtatacgt ttatattttt ggccaaagta ttgacaattc tttgtaattt 180
ctataaagca gaatgtgttc a 201
<210> 548
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 548
gtgctctgtt cactgatttt ctgatttgga aacaagtttt cttgggcagg aaaaggatgc 60
ttcagaggac atgatacttt agagaagctc cttcagcttt ngtagcccat ttgcgaacaa 120
cataacacat tgggatactg tatttcatca attctaaata tattttccca ctactacctg 180
gcagtatacc tatatttctt a 201
<210> 549
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 549
gataaatgtc tgtttaaaac atccattctc tctgtaatta taaatacttc tgtgataacc 60
ctcatcaatt ttaggacacc acatgaaaca tccttggtct nctttactga ttattccctc 120
agttcccatc cttcgttcct taaatttagc agcctgtcat ggaccctgat atcttcttaa 180
atagctattt tgagcactga c 201
<210> 550
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 550
caggcagtgt agacaccata taaaaggttt attctaattc taccctcttt ctcttatcga 60
attgctattt ttcacttaac ttatctatat cctgtaattg nccactagag atggaatatt 120
ccccaactta caatgggact aagacccaat aaacccattg taagttgaaa acatagtaag 180
ttgaaaatgc atttaatata c 201
<210> 551
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 551
gaattgtcac gagtttcggg accaccaagg atttaatagg gaaccaaacc atcagataac 60
aaagagatgg caatgaatga atgactgtct aagtaactaa ntccttcacg tattcccatg 120
ccattctaca ggcccaaaaa tcttttacaa aattgcctat aattcagtat gtctgaaggc 180
attgctcaag atttttcatc g 201
<210> 552
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 552
ttattgttac tatctttttt atctaataaa attgtggtca aaaataaatg caacaccatc 60
tgtacaatga ttgatctagc atgtgtttat ttacttgggg ntccaacaac aggaattatt 120
taaatgtaag ttaggaataa agggagttag tacttacttc ctagcaaaaa caaattctgt 180
taattttagg atggctatat c 201
<210> 553
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 553
tcagtgaaaa atcaactaat tgagctaata gtagttaggc aactcctttt ctcccctgat 60
tcatttcata ctcccagaac caattacaat aatgaggaat nagatggaac tgggaaggtg 120
tgagtgcata aaatgttagc gtttctatta tgggattttc ttactatgcc tgtcctatac 180
ccattctctt tagtaagacc c 201
<210> 554
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 554
tgattgtcaa aaatgcatag tagtatgctc caaggatcaa tcttgttgta ccctgaaaag 60
aatagtacca atattggctt cttgtacaga tactattcat ntattgcaca atgattcatc 120
aataacaggt gatatcatat ttatggaata tttatgttgc ttaagttgga ttctcttttt 180
aatgacacag aggtggtaaa t 201
<210> 555
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 555
gacaaattag ttgtgtttgt gtcttttatg aaaaatgtaa taaatttccc agaactctta 60
ttcaggagaa ttcccagaag tccattcaga gttagttcct ntatgcaacg cttggtgtaa 120
agatataaca cctaaggcct agccacgccg aagaattggt gcaggggctg accgcaggga 180
gtgacagaga cttggactga g 201
<210> 556
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 556
caagcttcgt ttatttacat cacatgtaaa atgagcataa taatccaatc taattcattg 60
agttggatga ggattacaaa gaatttatta tggtaactgg nccagtttga cttccataaa 120
aattagtttt tattatgaga atgctaattt atagatggat attaagacta aataacaaac 180
ttggaaatgt atatgaaggc t 201
<210> 557
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 557
agccacttag ctggtaagcg gcaaaaacag gatttaaatc atgtttatct cattctaaat 60
ttaaagagac ttaagggctg gtcagctgca tattaagctc naggtatgtg ccttgctttc 120
ttcatctatt gaatgggaat aaaataacac atcacagaat tgctttgaag actacgtaag 180
gtagagcagg aaaagtggta a 201
<210> 558
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 558
tgcatagaat gactaccatg tgcaagacac atcattacaa ataaaagatt tccttgtctt 60
caactttaag atatcttgtg actaaaactt tccacaatta naatctatgt tttcaacatt 120
caataattag ctatagttat tccaaaacta tttctagaac ttgccatatt gaagctttaa 180
agttcaaatg aagtatttga a 201
<210> 559
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 559
ctctgatagc agacttaagg gtgacattta ttttatttaa aaaaatcatt ttgaacaaag 60
atttacttcc tctctttacc accacttccc catcacttaa ntcaattaca ttctgtctcc 120
aaaaaaatca gaaatctttc actagttcta accgaatcta aagacgtcct cctattctaa 180
atgtgtttat tttaatcagt c 201
<210> 560
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 560
aatttcacac tagagattat tttacataga gtatagttct aattttgtga gttctaacaa 60
catagaatag aatcccttaa tgcctttaat cacttaatcc ntgtgacacc cccacttcca 120
ggaatatctg attacctcca tgatttatgt cttcttgcaa agcttaacca cagtagctgg 180
cacttcctca tctggcctca g 201
<210> 561
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 561
atttctttgt ctctagttta aaagaaatac aaggcagaaa cacttagaag ttctcctcaa 60
tttcctgctt ggataatgag tttcttcacc tagggaaata ntcatttaga aaacttaaga 120
atagaagaaa gagaactgtg atcgaggaac aataagaaat aaaacttcaa agattatttt 180
gatgcctgct attttattac t 201
<210> 562
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 562
aattgtaact gcattctact ttgtttattc tttactttca aaattatcca tttcactatg 60
gtatttataa acatattcct tttaatagcc aacggcaaca ntaccttgag agagagaatt 120
aggaaacatt ctctttgtca gagctcaaaa tgatatcctg cagagtgaaa gagcactttt 180
atacaatata aatacttaac t 201
<210> 563
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 563
ttcacaggcc attaatttta aattatcagc ataccatggt atcttggggt gaaattccct 60
gggctccttc agtgtaagtt ataagtaggt tcagttgtat ntaacagaaa ctccctaata 120
acagttaacg gatacatgca taaagggtca gcagttgtga actgatatga ttctgttttc 180
agaaacccag gcttttactc t 201
<210> 564
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 564
taatgttacc ctaagtgaaa agaaaagcaa gaacccaaat gtttccccca ctcaaatcct 60
gtaccaaaat acacaaatat aaattatttt ttcctaaaac ntctttcagt gaaccgcagt 120
tcagttcaag gtaaagacta cctagcaata caaaaatgag catatacagt ttatttccta 180
attcatcctg ttacatgttt t 201
<210> 565
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 565
aaaatttaac aaatatctac actgaactct attatcgagt ataaattacc ttcttatagt 60
gcattccaag gtacaactat ctactgaggt ttctgaggac ncttaattat attttgactt 120
atctatatgt tgtatcattt acatacaaaa ttatattttg atagaacatt acttgtttat 180
tatttatgag gttttgctac a 201
<210> 566
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 566
aagccctaga gtcagcattt taaataagcg cctttggtga cctttatgca ctttcatgtt 60
tatacacttc tttggcactt ttatccaaag ccgtggaaac nccaaagaca tctatcaaga 120
acttgttctt catatggcaa ccatatggta ttgcgatctt tcttgtctaa atttacagat 180
ttaccattac agactcaaaa t 201
<210> 567
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 567
ccttttctcc ccctcttcag cactcctttg cttcttttac agataacact ttacagattg 60
gcttttcaga tagtgggatg tagtcaacac tgacactttt natgatcgat caaaccagtt 120
tcctttgttg ctcactggcg acagggttag tgattttgct cacatcactg tcagacacag 180
cattattgaa gttttaaaaa a 201
<210> 568
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 568
taatctgact gatgtttctc tgaaggcata cagtcaaaat cgaaggctac aaaccataat 60
ttgattttta gtaaaggtaa agatttggta agtactatac ngaaatactt aacatacttc 120
atttcacctg caaaaatggg tatgttttgt ttatactcta cctatgtcta tgcaatgcta 180
tagttgaatt aaattttgca a 201
<210> 569
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 569
atcatgagcc atgggtggat tatatcatac acaaatattt ggtcaaaaca cacccatctc 60
aaattatcct ggagacctta atctaagaaa gtaagataaa ntctctttcc ccaaacctac 120
agaatactac tttaggtatt ctgagtcttc tactttttaa atgaaacata ggaaggtaaa 180
aatatttttt aaaataaagc c 201
<210> 570
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 570
agtaagagct caggggctgg ttctgtgccc acccctcttc atccttgggt aaatgttctc 60
cttgcctcct tgagattcca atctagaaca gttagggtga nttactctca taaggaacat 120
tctcaaaagg agtctaggtg attttatcat tggctaatat attaaaaaat atgtgtgtgc 180
ttatgaattc atatcaaata a 201
<210> 571
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 571
agggaacgaa attgtttcct tccctatact agctaaatat tgggatatgc cattaccaaa 60
tgttacaata atggcttaca tttcactgtg taccttagca ntagaggaaa aagaagagaa 120
aaggaaaatc atagtttttt tttttttttt tttttttttt tttaaatgga gtctccctct 180
gttgcccagg ctggagtgta g 201
<210> 572
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 572
ggatagactt taatgaaata ataataaaaa aacactccca tatttctacc cctttgtaga 60
cacaaaagca aagtaacagt ctgttatttc agtttccctg nctaacttga tcatatgatc 120
atgaactttt attctctcct ttcctcaaca ggcgcaaaaa tgctattaat agaataatat 180
gggacagaaa agtggatgct a 201
<210> 573
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 573
cacactttgg aatttggagg atgagttgtg gagaataaaa aaaaaagtgg tgggaagaaa 60
acatttactt gtctgtgttt attctctgct gggtcttagt nggcaaagct acctttgtag 120
taggtcctct tttcttttat ccttctttgt tgttctttca aacaaaattt ggagatgtta 180
cccactttgt cccagtttct g 201
<210> 574
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 574
gtcacttctg cccatattcc attggccaaa ggatatgata ttgtctagcc caatatcaat 60
tgaatgggaa agtattcttt tcccatgtag gtggtttagt nggaatgaaa ttttgctgag 120
cagttactat cttccacaag tagccaatta gccttctaaa caggccaaat gagctgatat 180
catcatgctg ttaatttaat a 201
<210> 575
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 575
tgattttgta tttaaacatg ctaaacacaa tattttaatc agacagtgtc aacaattttt 60
agataaattg agaaattaat aaaatgcata tgctactggg ngtgcttata gtataaaaat 120
aaagatagaa gttttaaaaa gcatagaaca aacaccaata tttatttcac tatttaaaaa 180
atactgactg tatgatgatg a 201
<210> 576
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 576
gtataaaaat aaagatagaa gttttaaaaa gcatagaaca aacaccaata tttatttcac 60
tatttaaaaa atactgactg tatgatgatg ataatgataa naacagtttt ctacagatac 120
cacatttctg aggataagca atgttaaaag aaaaacttta gatcaattaa atttaacaga 180
atttaattga gcaaaaaagg a 201
<210> 577
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 577
ttgccccatg atatttataa ttaaattaca ttgtatattt tggtataatt gggttactgg 60
ttgagttttg taaaacaaat agaataaata ttgcttatta nagtttatca cacagtccaa 120
ataacagcga attcacatac tacattatgt agataatgga acaactaatt catgtggtct 180
acaactgact ttgtactacc a 201
<210> 578
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 578
aaatattcat gctataaaat taattattaa ctgcgttatt taatgagaat acacaacttg 60
tattttcctt tagattttca aagtactaaa actctatcta ngcaggtaag ctttaatttg 120
aaaaagcttt agtgtttata ttaactgctg ttcacttctc tgcctttatt gccactgcca 180
aattggtaga acaagttaaa a 201
<210> 579
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 579
actttatctg aaaaggtctt tgccgcatga atttgagaaa gagaattaat cctgcatagt 60
cgactgtagc ttattatttt tcactgtagt tagtgagaaa nttagtcaaa cacaatttta 120
atgagagctc tttcctaagc tttgcctctg ttttatacag gtagttttta aaattcttca 180
caaatgtaac ctggccctac t 201
<210> 580
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 580
catctattca atcagttgag ggacttacaa ttttattttt ggtttataga gaacacatca 60
aatgaacctg tagaaccact tggcaaagtg atatataacc ntaagaaaga tagccaaatt 120
cacaattaaa agatgaaaca attctggata aaattaaaca caacacatga agcaatgtta 180
aattgtatat taataaactc c 201
<210> 581
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 581
cttgagtctc aaggcattca agagttgggc aaagcacagt catttacata ggttacatca 60
taaatgtgct ccctggaagg ataaaccaca taggcactgc nttcaacata gacaatgtat 120
aacttttgtc ttccagtcaa atagttctag ttacagtatc aaattataaa acatctactg 180
tatcttttat ttgaattttc t 201
<210> 582
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 582
gcttttctgc atatgtttta accttcaaaa aataagatga gaagctcatt taaaaatcac 60
ttctaaaaat gcaaaaggaa aaatttcata gcagacgaca ntgcatttta atccttttca 120
taagtccagt gattaatggg tctataagat acattatgga gacctcacat atagctgagg 180
ggaaattaat ggataaagaa t 201
<210> 583
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 583
gaattttttt ttcccctgag tgtaaatgga atatcaaacg agcacatttt aaacatacag 60
gattttggca attgtgaagt tttgttctgg atgctcttgt ncttaaatta tattataatc 120
atattagtaa agtgagccag tttgtactca ataccatact ttattctttc ttgccagtcc 180
ttactaaatt cagcctacga a 201
<210> 584
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 584
ggctgaatgc tgagattgag aaagtgcagc agctcccacc ttagggaaac cacatcccag 60
ggttcttcac gcctgtgctg ctgccgtggg tcagtttgat ngtttttaaa cttctaccct 120
ggcactccac ctgttttagt taatgtatat atttggctgt aagttccatg aacccttcct 180
taaagatggc ttagcctcgg g 201
<210> 585
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 585
aaagtccagc acaagtggat acagggtata tgtgagctca tatcttcaac tttagggggc 60
aatataaaat aacaagaatt tgatgatttt aaaatgttga ngaagacttc tggaggtatg 120
gcagaaaaac atctgattta gtataatccc ttttaactaa aaatttatgt gctatgggac 180
aaaataaagg agaataaata a 201
<210> 586
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 586
ataattaaat tttaaaactc tggttaagac aattgttttg atgtctcctg agaggaattt 60
ttgccaaggt tttcctaata ctggcttctc actttttgtt ntcactccta atagtctaca 120
ttctaaaaaa aggagacttt tttttttttg agattgagtc ttgctctgtt gtccaggctg 180
gagtacagta gtgcaacctc g 201
<210> 587
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 587
aaatatctga tgggaaatga aaagccatta tggctacctg gtagcaagtc caattacaaa 60
tgactccaga gccctctgca atgtgacctg actctaaatc ntcctttagg attgtcatcc 120
agtctgctgg ccctctgctt tctgcctact cacatgtaat tgggaaatgg aaggtactta 180
tctatcttgt tgatggcact g 201
<210> 588
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 588
tgagacagag ttgtagtgga catttttggt tttatttatt ttatcacctg tcattcattc 60
attttatgtt aactgtacct ctcttgcctt gtggggaaac naatcccatt tttcagtctt 120
gatccataca tgctcatgga gttgtcatcc ctccatctgg aatctccctc tagaagtctc 180
ctgtgtctgg gtctagctaa a 201
<210> 589
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 589
ccaacagaat attatgttgt tctactttga caataggaat tttattactt cgtgcatata 60
caactacagt ataaatgtgc ttcttcatta tagaacagta nttcttttta atcttattga 120
aaacatatct taaagtccat ctaatctgat cttgtttctt ccattcgcat ttgttcacac 180
cagaaactta agtctcacta g 201
<210> 590
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 590
acgtttcttt ctttcttcat aagcaactat ttgggccata atagattgga atgctgaaac 60
aataaaatat gcccaacact aaaaaaagaa tgaaatatct ngaaatacag ctaactaaag 120
tgccattttt acatttttat caaatcgtac caaagatata gacgatctcc attatttttt 180
attttattta ttttttttga g 201
<210> 591
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 591
attttttctg tcatattatc cacaaggaag tcattacttg ctaatgctca gagtggagta 60
acctagtccc agaattctgt gttatggttt gttttctggg nctactcatg gtaaaaagaa 120
gtgcattagt aacgtcaatt ctgcagaaca aaagccactg taagtattta atacaggttg 180
aacagataac gtaaggtgca g 201
<210> 592
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 592
gatactaaca gttctggcac aaaatagatg ctcaaaaagt atttctcgat caaacaaaaa 60
tatgttgttt taatgtagtg acttgtacct gtgcagcatt nccagtgatt tgtttatagt 120
aggccctgca tgtaatatac gatgttcctg ttggcatttt gtcattgcct ttcttaataa 180
cttcagactt actttgcaac a 201
<210> 593
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 593
ttctgtatta taagactgca tatatttgtg caatataagc cagtggtctc agccatattt 60
agaagaacgt gcattgtttg catttggcaa tgtctgaaac nagacttaac cacaataagt 120
ccaagtgact atccttgagc tcatagtaca ttactttatt tactgcaggt ttataaatac 180
attgatatag gttagattag g 201
<210> 594
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 594
ccatgatgta aaaacaaaca aacaaaaaaa cttcctgtgg aatagtagtg atagtactac 60
atggtatcag acatggtatt attccatatt attgagagag nttcaggtat tattgatgac 120
cattttttcc taggcagcaa ccaattattc ctgctgtgtc ttcttgagga agtcagcaac 180
tagccttgca tatccaatgg g 201
<210> 595
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 595
agttttaaga gtcatgacaa ctttttcttt ttaacacaat ttctcttaga atcattaaag 60
tcaattgcta ataattgcat tggcattgtg ataacttgag ntgtaaccaa ggaaaagcat 120
gttcaatatg ggttactaat tacactaata acaatttatg caaattagtg actaatttta 180
cattagcata gtggtaatca c 201
<210> 596
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 596
cctgtgttat atccaatact aactcagatg aactaaaata ctcaaatgtc tcttaacctc 60
tacgttactc tggcttccca gggagatgac agtattttag nggcacctgc tagcatcaac 120
attaaagtca tgtaattatg tttttctttt ctttttttaa atttatacat atatatattt 180
attatatttt aagttctagg g 201
<210> 597
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 597
tccctcctgt tctccatcag tgtccttatc ttacattata ccatattcga cctgtcaaga 60
tatttcaata tttcccacat taacaacaaa gatatgtaaa ngacgatatt acactgtcaa 120
atcccctaaa catccctgtg tttcatttac aaattctcga gtcagtttgc cgatgaatta 180
acatttacaa ttatagttcc t 201
<210> 598
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 598
aaacagaaaa gaacttctaa agatgtaaat ttaatatgtt ttctaagtat tttattattc 60
actaaattaa attcatgcct ttaagtttct ctctgaaaac ncccatcttt ctttctttgc 120
ttcactgaac accctacagc ttcccaaagg gaaaaataaa taaaggctct aataatgagt 180
agtttcccaa ggcacatctt g 201
<210> 599
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 599
atccccaagt tccactatga tcatcatata aatctttaga tgccatttca acttcacttt 60
tctagatcat tttagataac tatgtttcta aagcagaata nattactact tcctcatttc 120
cattaactgt tttgcaagat tttcaggtta aaatacaaag gcatgaactc ggctcactgc 180
agtctctgcc tcccaggctc a 201
<210> 600
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 600
tgatgattaa atttttggta tactatgaat tttagatttc agaatttcaa ctgaggaatt 60
gtgaaacatt ttaacatgct tatgacacac aaacttatac nggcatatgt ctatatttta 120
atattcagac tttgtatagc cttatattca aggtgtcttt ttttggaagc gacttatgtt 180
tcctgtttaa tgctcagtct g 201
<210> 601
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 601
caagcaaaaa agcaacttag taggaattgg cattctagtc ataaggagtc tgtccatcct 60
ttctgaattc cttttcttca tttattccct acaatccaca nttcaccaac gtcatttcct 120
gtcgtgtgat tctgtggtgt ctggataaac tatattacag tttctggaga aagagtctcc 180
tgtttacaca tcttcgtatc a 201
<210> 602
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 602
accaattaac acatccacca gtttggagct cccacccatt taaatggtct gatattctcc 60
caggattcct ctctctatgt ggttcctcca gcagcctttg ngctaggtca taatctgtca 120
tcaccactgg gcctagctct gcatcctctc caggctgttc tccttttgcc cccttaatgg 180
aagttcccct gcagctccct t 201
<210> 603
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 603
aaatgtgttg agattacatt tgttataagt taaagttaaa gttatcttag aagtatatat 60
atatacacac atatatatat gttaatcatt aacaacactt naaagagatg acagtgatag 120
taacatgccc ttgaatttcg ttaaggtata tcttagattt aaccaagaca cactagttta 180
caggagctgg aaaatatatt c 201
<210> 604
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 604
ggcttccagc tccgtccacg tgtctgcaaa ggatgtgatc ttgttctttt ttggaagatt 60
ttcattttta tttaaaaagt tgcctgatct cactgtgttt nggtctgatt tgtttacata 120
tgtgcagcag aaggtgctgg ttgacatact ttgtaatacg gtcagcaaat caaaagtcac 180
atagtgttaa ataactaaga c 201
<210> 605
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 605
ttctaccttt gaattctcct atcctcctct aattgctacc agcatatttt ccaaggaact 60
tcttaaaagt gtattttcaa gacacctttc tatatgcctc naaccagaat tacattcctt 120
ttcttttgtg cccttatagc atactgtgta tatttatcat atgatgttgc ttttgtcgtt 180
gttgttgttt gtaacttgct t 201
<210> 606
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 606
atgtcaagaa acagccttag ggcattacag aggatattat ccatgccctt ttaagtagta 60
gacagatgct gtattcagag agaggatttt tatgattatc nttcacacag cccaggtgat 120
tggtcaaggc cataaaggag tctgcaatcc ttggagaact tttggagtca ctttaaccat 180
aacgtaatgt attgcaacag t 201
<210> 607
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 607
ttttgttagc ttctgaaatt cttaatccat ttcaaagctt ttaaaagtta tataaatata 60
tatcttcctg attgcaattt ggagaacaca attatttact ngaccttcat tcaaggacca 120
aattcagagg gaagcatcgc tgatttcagt gcttgagata ctgaaaacag tgagaatatg 180
gtatctgccc tacctaaaag a 201
<210> 608
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 608
ataatgagag cagtgtattc attatgattt ctggggaata gtttcattag agaattgaga 60
aattattgct tttacccagt cactgctcta ccaaaaataa ntgcatttct ccacttatct 120
tcacatctcc atgaagtttt ctattatgtt ttaaagtgaa tgaaatgtgg catcacacca 180
agatattcat catggtgttc t 201
<210> 609
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 609
aaactacttt ttctttcaga taatcaaaat taatttttaa aaacctgtgg aaattatcat 60
acttctaaat gaatcaatca gttaactggt tacttatctg natttatatg tcaaaatcag 120
caaatagaaa attttaacat cttcgatctc ttggcttctg tcttggttca gtctgctcta 180
acaaagtaca atactgggtg g 201
<210> 610
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 610
gattacaggc gtgagccacc acaccaggcc tacttatcta tttctactca ctactgcttc 60
cactgtaaag tctgtgtgaa ttattttcaa atctgttctc ntctaactag gatccagatc 120
atacttctac cagctttggt agaagctacc catttccaac tattgaaagc ctctttgatt 180
agcagctcct taggaaaatg c 201
<210> 611
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 611
tttgtactat aaatttgaat actttgtttt tcttcaaaaa tggagcaatg tctgcaaaga 60
ctgtggatct atatctgacc accaagctcc aattgataat ncggatattg attttgtgag 120
gctttcctat tagtctagaa atgaggaatt gatgccttca gtcatagtat gataagaaaa 180
acataggcaa caagaaattt c 201
<210> 612
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 612
gactcatgac tgtgttttcc caggatatgc tgcattgata acaggggaaa gaattgtctc 60
acttttgtca ctaaatataa ccagataatt taatagaggc ngaggatgag tagtctacag 120
ccgtgatgtc tcaaaggcag ataactgttt gcagaggggc acctcttgag attgggcatc 180
atgaaagggg aggtaagtaa t 201
<210> 613
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 613
cgaatataaa tacatgtgtg tatttgcata tacacatgtg cacatacacg tacacatata 60
tataagcaaa atcatgttgt tttaggaccc ccaaatagga ngctttgaat acacaaagaa 120
ttttatttat ctctgtagta ttctaatttt ctttttatgt ctaaatcctc tgcctcagtt 180
tgttttaatt atgtcattta c 201
<210> 614
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 614
caaagtcttt acttgcactt gtcacatttc aaattctcaa atgtcacatc tcaaattctc 60
aataggctac ctgatcggtt ggcacggatg tcacgacgga ncagaccaga caacacaatt 120
ctagattgtt agagccctca tgaaagaata cagttttgaa tcacaaaatt aaacacacag 180
ctaagtgtat ttttacatgt a 201
<210> 615
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 615
atatcctttc agtaatctca cgcccaagta gaagactgta caaacaaata actgagtgag 60
atcatgcata tttttaaatt tcagtttcca agttgtaaaa ntaaagcaga aatcacggca 120
taaacttctg aacagtactt ttcttaggct ttctatcttt ttctaacaaa ctttgagatt 180
ttttttctcc tttcagttat t 201
<210> 616
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 616
gtgtctttta caatgatcat tactcagatt ctgtgtttct ggtaccgttt aaaggatggc 60
tggccatttt tccaggcagt cagattcggt gcctcagcct ntcttcactc agtcgtcctg 120
cgtgttccca ggaaggactt gatctttatt acaacgtcca caagccaaga gcacccaccg 180
tctatttcag tgacgcatgg g 201
<210> 617
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 617
ctaggagccc gattacgtaa tttaccatcc aggtcggacg ttgggagtgt gaacaggtgc 60
tgtgcatgcc gctgggacac aggtagatgc cagcgctgcc ngggaacagg agcgcgaggc 120
cacccccaca ctgagctgtt tcgtgagctt gtcagccttc actctcgtcc acttggatgg 180
ccttagacgc agttccaacc a 201
<210> 618
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 618
ggccggtggg tgacactcca caccccacct ccttctgagg gtaatgcctg agaaggagag 60
gaacaggggc tctagtctgt cgtttgattt ttcagaatcc ntaagagtag cggaagaact 120
gcatatggaa agtgcctgct gagaaaatgc aatgacttca ggtgtgttag agaatggcca 180
ggctttccaa gcagcctcca t 201
<210> 619
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 619
gcctgatgtt tcacatctga caaaactccc aagattggga tgcttcgcag cctctccacg 60
gtgccaaaaa atgagggagg tggtgtagct caaggcctag nttctaacgc accacacgtg 120
tgtatccacc acagaaatgc agctgccctg gagctggctt acaggcttga cactaagcta 180
gtccttacat tgaagggatg t 201
<210> 620
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 620
agtgggtcac cttttaaatc cacaggggaa cacacttcat ccctgcaagc cctgagaaga 60
aagaacatct gtgcatcttc ccagagcctt cataagtccc nagtgtgtcc cagtgatttt 120
tttaaacaag tttaatatga agaaatacta ttacaaacaa acaactatta gaaacaaaag 180
tttgggcttc attgagacat t 201
<210> 621
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 621
cgaaatggtg aagctttgga gagattttgc ggggaatgca ctggagaacc atgaagatgt 60
ggaaacaaac aaacaaacaa aaaaccgctt ttgcatcttc ngacatctca cttgtcatca 120
ccagcacagt gccatgcatg agtgacccat tgcagggaaa caaaccagag atctcccatg 180
aatgtctccg gaaacacaaa g 201
<210> 622
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 622
gggtcacccg ggtagagcga gagggctagt gttaccacct cgaggacaga ggagaggtga 60
ggattcaggc ccagcgggag ctggggtcaa ggagaggctg ncatgcaaat gactccatca 120
ccttcagtcg gcacctgggg cctggcctcc tcccttcccc caggcccaac ctgggcaggt 180
tagagaagaa aacggaaagg a 201
<210> 623
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 623
caacctcttg ggaggcagag ttcctaaaag tgtgggagat ttaaccagat cctcctataa 60
taacaatctg tcaagcaatg cactttaaat ccatttaaag ntatctttga gtaagaggtg 120
tctcctttaa atactgtaat acccataacg ctctcacaaa agctctattc atcgtcctga 180
caatgctata atgtttgtgt t 201
<210> 624
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 624
ttgtgcccta gaatgaagcg ggtgtgcttt tgtgaagcgt ctctgttttg cgtgttaatt 60
ctctgaatgc atgtgggtgt gtggggccca ccaggccttc nagtacagaa gaaacataag 120
ttctcacact ctcattcagt cccctagatg cagaactccc tagaaatgac ttagaataaa 180
cattcccaca ttatcaacaa t 201
<210> 625
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 625
ggactttatc tttaggatgg tagacgaggt ctcagaatgc caggagcact caccgtggac 60
tgtatcttta ggatggtaga cgaggtctca gaatgccagg ngcactcacc cgtgaatggc 120
caccacatgt tcttctgttg aattttgctt ctgtgccctt aggaatgagg ggcatgaagt 180
cttgcagagt ttgcaggaaa g 201
<210> 626
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 626
aatgccagga gcactcaccc gtgaatggcc accacatgtt cttctgttga attttgcttc 60
tgtgccctta ggaatgaggg gcatgaagtc ttgcagagtt ngcaggaaag gtcgtcacga 120
agagggtagc aatttaccat ctgctgtctt tatctgtatg ttccatacct tctccatcta 180
acacaaatcg gcagattcca a 201
<210> 627
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 627
aggatggctg agcactctgt tcggagaaag agccctcttc tcagagcccg gctgacagag 60
ggtgatggtg aggccaccat gccggctggg atcctaattg nccggagact atgggtggtg 120
atatgatgag gggtctgaga ggtcagccct tcacaaatgc ctggacccct acaattcagt 180
ttaaaggtga aataacattt c 201
<210> 628
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 628
cagtttgttg tgaaagtttc ttttcagcta atctttttta ttaaagtatt ttcaaggtcc 60
tatgtgatga aattcttcca gggaacattt gtcttttttt natgtcctgt catctatcaa 120
gcaagccctt tccctctttg catggaattc ctcattgtgt gtagtgttaa aggacatgat 180
gtcctttgcc ctccccagtg g 201
<210> 629
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 629
atactggctt gttttttaat aggtatgcct tgctaacaca agttttatta cagtcaactt 60
tgaagcacac cataggcttg tcaaatgttt tgcctagtta naacgaagaa aaataaatta 120
atttttaaat aaatctcgga agaagctcac ttttaagcaa aaacagaaga aaaagaaaca 180
ccactctttg aaacatatta c 201
<210> 630
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 630
ccctctttgc tcctggtggt tcacagagaa ggtactggac acacatttta aatataagct 60
tttactacgt ctctcttgtc tgcttatgaa gacaccagcc ntggttcgtt agatgcgtgg 120
gagccaccat ttctgtagtg gagttccacc gcgccttttc aggaggaggg ctggcccgga 180
gtggggagcc acagcagccc c 201
<210> 631
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 631
aggaactggc agggaaccac aaatgggagg ctgagagctg agcaagcatc tccatcctgg 60
agaaacatta tgatgtgcct ggccagagtg gaagggttac ngagttgaga ctttaggaag 120
cctgtgaccc ggtggtgcag ccctgcacca tgcgcaacac tgagtactgt atcttcagag 180
gaaagacaac catgacccag c 201
<210> 632
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 632
tggcccaggc acatctagct aaccccagaa tgagtcaaga atgaacaagc ataataggtt 60
tcatccccag acaagtctct ctgacttcta gaaaaggagc nggggacttg cagaaaaggc 120
gctcagggca tttcccctgg gcaggaggga gagaagcaga gggcaggagt gaagtctccg 180
ccaacacatg ctactgacaa a 201
<210> 633
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 633
tgagccaagt agacttacag tatggtccct gttctccctt tacactttgc tttaagttgc 60
atggtggtgt gcaaaaatcc cttcaggagg gttttttttc nagctgatca agttcagtta 120
acccttcaag ccccatttaa aatcttctca cattatcttc taattccact ttaacattgg 180
ccaatcattt tcccgtgggt t 201
<210> 634
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 634
aaatggacaa tccaagtcca ggccaaacag aaactagaaa agttgcctca agccctaggt 60
cctacaaata cctttcactg tggaggtggt tttctttagg naccttgcta atatggaaat 120
atatttcaaa gtcagtcgac cctgaatggg ttttcaaggc tcctaaatga ttatgtaaat 180
tttagataaa cacagttaat g 201
<210> 635
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 635
gcagccacag tgtcccctgc tgccatcagc aaggcctgcc ttctgcatct gagccttgct 60
ctagactttt ctgtctggaa cctcactatc ccacctggcc nccttctcat gactgctcct 120
tgaagccttt attttcgcaa ctaaatgctt cctcctcatc ctctcccagc cagaattccc 180
ccaccatcca tcgtcctcat g 201
<210> 636
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 636
cctttacccc tgccgtcccg ggacctcccc gtttgagaac caatcactga gctgagcggc 60
gacgctggct tcccaccgac cacttcgatt tcaccggaat nctcgagtgg ggctacagtt 120
ccacctgcag ccctgagagc tctcacctgc cctcgaggac gggtcctgtg ggcccggtgg 180
actcccaaag cggcgcgctt c 201
<210> 637
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 637
ttaaggattg aatgtgatgt atctttgtca gaaagatcat attgattaac agggcacaag 60
aaattatgca tatatgatga agtgccagct tcctacctga nttggtctga tcttgagggc 120
aggaagatgc acacagtgta atatttctcc agactgtgat tcagtgtgga ttcctaggcg 180
gtcctaagga gcacagccag g 201
<210> 638
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 638
tagccagggc aacgtaaagg gttcttttca tccttttaca cttgtggcag cctttgtcac 60
acatcgcctc attacgttca ctctgacctg ttctacacct naaacccgga actgctgcca 120
gtctccacaa tggctctccc acccacagct ccctcttgct cgttggcttt gacacagggc 180
atctgtccct tggtcctaca c 201
<210> 639
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 639
tttgttttgt agatacaggg tctcactttg ttgcccaatc tcgtctcaaa ctccctggcc 60
tcaagtgatc ctcttgcctc agcctctcaa aattacaggg ntggcagata tgttaccatg 120
gctggcctga aatagatcta aagatgagtg cttgagtgta ttttcccagc actcattctg 180
taacagcatc tagatgaaaa a 201
<210> 640
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 640
tgtgtgacag tgtacataaa ctcatatgta aaagtatgta cacttaagtt taataaatct 60
gataattata aataatacat acatgtaatt gagaaagaaa ntatggaagt tctcttgttt 120
cctaggaaat aaaaaataaa gcaggtattt tatataatat ttcagagttt agactttgga 180
ttatgtcaat ggtttttgtt t 201
<210> 641
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 641
ttatattttg aatgcccttg aataaattat tatgtggggt cccaggcatt ttgccaggtt 60
tgagatgttt caccatattt cttggtaatt tggaaataca naactttgta tccaactctt 120
aaacaggctc cttgttgccc aaggtcagta tatttattgg tatgaccaag gctgagaaga 180
cacatttcct ctatttcagg c 201
<210> 642
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 642
attttatcaa aaagtggtta aattttgaat atttgttaaa atgaacccaa aatatatagt 60
gatgcttgac ataatttaaa ataaaatatt aagttgatag ntatgctact ttaaaaattg 120
tgtaattttg aaattctatt gtatgtcact tcatggaaat tatttttgct ccaaatatat 180
tttgaaatat gcagtcttac a 201
<210> 643
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 643
tacacttata tagaattagt tttgatgact tatcctgaac aaattttaag tatacatgaa 60
taatttttag gtcatggatt tggtatgaca tttattacat ngtaccttcc tataggcaga 120
ttatatctct acattcatca tatgtgtttg ccatttgatt gtcgcatgcg atgaaactgg 180
aacagacttc atgccatccc t 201
<210> 644
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 644
aattttgtat attgaataat attgagactc aaactgaaag gaatataata taccttcaaa 60
agatccaaag gtaatatatt tctaaatttg gataaagtag ntgctacaga catataataa 120
ttttttcaat tttgtcagag aaaataaggt aaaaaatcct atgttttatc ttgaactatg 180
agaaacacaa agattttctc t 201
<210> 645
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 645
tacactagtg tttattccat aaggacagaa tcatgcatat tcaatctgaa ttaaataagg 60
tatgcaaggg aaaatatgac agtatagtaa atgagtgtac naaaatcaac atctaagttt 120
agagttcaat aaaaaatgta attatattgg tctgctatga tttatgattt actcttgctg 180
tttattgctc agcaattgat t 201
<210> 646
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 646
gcgtaagaat caattgggat gagagtttaa aacaaatttc tgggcctatt taattaaact 60
taagtttgat tgaatagatt taaagaaaga tacaggaaaa nactttttgt tttaacaaac 120
tattcacatg atttcgaagc aggcattaaa tacgggacca tttggaagat gcagcaacac 180
aggtgcagat tctctgcagt t 201
<210> 647
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 647
tcactatagc aggttaaatg tcattttcat aaaataaaaa gtaaaaataa aagtctttac 60
aaaagtttgc agtcatttaa gttggtcatt aacccaacca ntgccatcta tggcataata 120
tctaaaatca acgatgtact aacctgctta tttttttctg tgaatccatg acaaaaatta 180
ttcaccaggt ccattaacca t 201
<210> 648
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 648
ataagtagca atctggagac caccatagtt cagaagttaa gtccagaggc atactttgag 60
acaagagaat ttccaagaca gcggcaggga cataaaccca nataatccag tgtatgtttt 120
taaatatcca catgaataaa agaatagtgt atgactgttc tatttgttca catatagggt 180
tattattgga atacactgat a 201
<210> 649
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 649
ttttcagtat ttggagaaat ttgcatatgg catttttttt tttctgaaag gtagtgagga 60
ataagtgggt ggattgtgtt aggcacgaca tctcatccca ntggtgacat tttttgacac 120
tcattgggca aagcatgtat agacaaaacc caaggatgtt tttataaagg actctaagat 180
ctggttgagg tagggttgga g 201
<210> 650
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 650
gtactttcag aaattagtta tatttttgca tgttcatgga catactcata aatctaactg 60
gacttctttt ttaagaagtg aaacaaagtc tgaattctcc nttgtcatgt aggcctcagt 120
tccaggagct gtcctgtaag tttcttgaga aaaggtgctc ccaacctgta cgtgggacct 180
ctcgacagct gcctcatagc c 201
<210> 651
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 651
ttatttatct ttttattttc tttaatactt ttcaggattc cttttcaatg attattgttt 60
attattgaat ttatgtatgg atttatatca ttgaatttat ngtttttgga taatgtgagg 120
ttcgtgtcta caattttttt ccaatctaga attgactcgt tctaatatta tttatcaaat 180
agtagatttg cctttttcct t 201
<210> 652
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 652
caagacaggt atttatacct catgtcactt aaaataccac taattacata taacagttgt 60
aaaaatacta tgtttccaaa tggtaggcat atttgaaaat naagatactt aaaaattaaa 120
ctttatagcc atatttagaa tcacaaatta aggcatgcct tgatgtaatc tttgcagatg 180
aaagggaatg agtttttggg c 201
<210> 653
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 653
tattggagtg ctgggttaaa tttcagttct taatgtgcaa agaaatgaat gggaaatgat 60
gtaatgtgag tgaataaaga tacttatttt taaatgagac ntaaaagcag ctggagtgtg 120
atatttcatt aactcacgca tgcgcttgtg tttgtgtgtg tgtgtatgct tcacgtttgt 180
ttgctttaca atatggggca t 201
<210> 654
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 654
aggtatgtct ttaatgtcag tgtaagagca ggctaatgca gtgtgtatct atatgtgttt 60
gcatgtgtgt gtatatatct ctatgtactc agcataaata ngttggttta acattttata 120
tacataagta aagtagtact tattagtgaa aataatgcaa gttaactgag aatgaaaatt 180
atttcatagg ggtttctata g 201
<210> 655
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 655
gcctaaaaaa gagtgatatg gatggatatg tggagagaac acaaaatgtg agaatttttg 60
tgtcttgtgt aatgcttatc cagagctatc cacaccaaaa ngttttcaac aactaaaaag 120
aacagtaatc ctatgaccac aaacattttg ccataataac cgagataaag gaagtgcagg 180
cgcccaccaa catggattct c 201
<210> 656
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 656
acttgtatag agaagggaaa ctttcttcaa cttactcaaa ctaagcaaat ggaacatcag 60
ctaaacaggg cacttcaggg atataagccc aaaactaata ntatgctggc ttcttgaaga 120
taagataaag tgcatttttt gccttaggaa aagaagcaca tcatttcaaa taacacggat 180
tattgattaa tagttcaggt a 201
<210> 657
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 657
gattacaaat tgctgtgtta aaaagatact gagacgctca gggggaaaat aattaaatgc 60
cgactaacta aattaattct cccacatccc aagctgttct ntctccctta tgcctttccc 120
tctgccatca ctgatgatca cgtacgtatc tgttagaacc tgcttctata atgaattcaa 180
gttacaatga attcaggttt g 201
<210> 658
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 658
acgatggttg gtcctgctca gcatgaagtg aagaaagagg gatggagaag gcatggccaa 60
cacagtgctc cataacattc aaaaatgtat tgttgatctt ntctccatcg ttatccaatc 120
tacagatcct tattctcacc actctttgta ttgctcttac actttcatgc tacagcaaat 180
gcatattcta ctcttttgtc c 201
<210> 659
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 659
ggagcactga tgatgtgaca gattctgtgt gagaaagcat tgagaatgaa agggtgagca 60
ggagttacta aaagaaagag gttagcatga gatggggttg ngattcagaa tgaaaagcaa 120
atacagaacc atcccctcac acccctcccc cagcagtaag atacagtaca ttgacactaa 180
aaaactatac ctcactccag g 201
<210> 660
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 660
gttttagaac tgtttgtagg ctgtagaatc tctcatatct gcattatatt atgtactata 60
tttctgctat attgaatttc tccggagaag agcaaaatac ngaataccaa acctctcaaa 120
gctgtgtgca agtgctgtta catagtatga ccactagatg gagatcgtgt ccaggtggct 180
aaaacttagg cttccttgac c 201
<210> 661
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 661
ttatttttaa aaatcagctt tgagattaac aattagatat caaaattatt ctaaaagtat 60
atttaaaaca tacttatatt tgtacatcag atttgcttat nctcactttt atagccagca 120
aatagttccc ccaaagacta aaccaattta ggtcaatttg gtaaaaaaaa aaaattatgg 180
atttactttt ggcaaatttc t 201
<210> 662
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 662
atgttggatt ttatcacttt ctggtaagcc acgtgttaaa gatgaccaat tatgagaact 60
aagtgaatgt gtgttaaaag cagaaaagcc agctgtttga ngctcaatgg atccagtctc 120
aatttccaat ggactcaaat aagcaggcta gctcaactaa cacatctaga aaaatgcagg 180
agagagaagg aaggaaaaaa c 201
<210> 663
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 663
aacataaaaa caatttttga aattgcaaga cattggaatt tttttacttt aatggtaaaa 60
taagtaaaat atcataatta taatgtgctc tacttttaag ntagaaaaac tgattataat 120
gagcaatatc tctttcaaaa attttacagg gatttatata ataaaaccat tttaatgatg 180
cgagatgcac atattcagtt t 201
<210> 664
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 664
gaatatgaca aatctttctc cactatatgg aaataagtat atgtgtttgt gtttgttcat 60
atacacacac agatacatgt gtgtatatac ataatacata natttcttat tgtgttatga 120
attatatttt atgaaaatta aaacaaccta ttcctgataa atacctcttt ctaaaatgat 180
gcatattttc aagctgcaga a 201
<210> 665
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 665
ttcttagaaa gtaatttttc tgaatggcaa gggttgggat gatgggtagt cctttactct 60
ttctcttgga cgacattaat tcttataaaa ataatgtgac ntagaaagct gtttatttta 120
aaacctgttt tttagttttg ctctggcaat aggactccaa tatttaccta gagaatgaat 180
caagagcatt tgtctgtctt t 201
<210> 666
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 666
cttcctggtt tctgtggtcc cgatagaact ctctctctcc atactgaaaa agaattccag 60
atggcttcat gatggcaaag aagccagtga gaactcaccc nttatttcat tgtataactg 120
atggagctga agattataaa caaatgttgc attacagtat ctgaaagggc cttagttgtg 180
aagaacagaa atcagttcta a 201
<210> 667
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 667
agcaagagaa agactacagt gattagcaac ttttcacgta cctgtggatt ctcccaagac 60
aagcccatcc ccatccccaa gaataattgc tttcaagctc ntcatggtct cccttctttc 120
ttccagaaag atgccttggg attatgtctc ctttttccca gacaaacttt taaaacataa 180
tcaaaatata actaggtttt a 201
<210> 668
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 668
ccaattattt tgggctctgg attgtcaggc gggagacctg agttactcac tttgtgtttt 60
cactgcttcc ctggttttaa aaggtcattg tgacaagagc natagaagga gcttgttcaa 120
gatgctgatt cctggccacc acgccctgtg cttctggtgc agtaggtctt cagtaggaca 180
cagggacttg catctttagc c 201
<210> 669
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 669
ccaggcccgt gataggattg tgtttcttgg ccacgttgtg gttgagtggg ttctggctaa 60
tgagttgtga aaagtgatgc atgtcacatt tagctgttga ngtgagacca ttggaattcc 120
tttcatcctc tgcaaagtga cctgcaatgt aagagatggt ggctccttta tcagcctgag 180
ttcctcagtg atgatgataa g 201
<210> 670
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 670
ttaatctaaa tacaaaaaat tggcagactt ttccaattac ctggaacaaa tgaaggaaaa 60
acctactgaa gcatggccaa agtgctcaga tgctttagtg nggtatgtta atttgctagg 120
gctgctgtaa taaggtagta cagactgggg agcttaaaca actgaaatgt atttgttcac 180
agttctggag aatagaagtc c 201
<210> 671
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 671
cagctttagc tgcaataaag tggtattggt ctctatctga cccctacaca tatttttcaa 60
ttagtctagt gtgttatcat cgtctttaaa ccataaggac nctttagctc aaatgagcct 120
tctatgtgga aagagtggct aattaagctc acgtgtgcca ttaattcctt ggtttgaatg 180
agtacataag tttccttcta g 201
<210> 672
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 672
gaaatgttaa ggcttttgaa ttctagggtt tgagttcaat gttctcaaaa tatgttgatc 60
atcaaatcca acttccaggg actttggact tttgtgaaag nctaaataat gtcttttaaa 120
aagcaaaatg taggctgggt gcagtggctc atgcctgtaa tcccagcact ttgggaggcc 180
gaggtgggag gatcaccaga a 201
<210> 673
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 673
ctatgcttgc gtatagatag ggaggaacaa aaggaacaaa ctagaaagga tcaaagatac 60
taactttagg gaaactgacc ttccttcata aaggaaaagg nttgcctgca tctcctaccc 120
agttctttgc agaattcaaa agggctccta ttgctggacc ttagtacagg tcagtgagat 180
aaatcattca ttgattacct g 201
<210> 674
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 674
tctgaagcac actctgtatc tgcccttaca gctgcctgcc tggctgcacc aggcagtgat 60
ggaggggccc tgaagtctaa ttcacacaat gctctggaac nctcttatta aggccactag 120
atggagggag tggactcagg gatcatcggc agtgcccaat taatagtgtg catggtggaa 180
tggtgtcaat tagtaatact t 201
<210> 675
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 675
aaaagtttaa agccagaatc tctatctcct tcactaaaat atttagtatt tcatgtattg 60
tggcaggact catgtgttaa gtcataaaaa cacccatgaa nttaagactg gaagcctggg 120
ttataaccaa gtaagcactt aagattgtca tgctaaccaa tggtctgagt actgctgcta 180
ataatgttta ttaggcaatc a 201
<210> 676
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 676
aatagtaaaa gagccaataa aatataaagg aacctgcatt ttagtactgg aatttttttt 60
tatttggatt gaaaaatgtg tggaaaatgt tgtctacttt nttacaccat ttcctgatag 120
attacatcaa tgcttcctag tgatgtaccc tactgtgaaa acaaaacaaa acataagcaa 180
aaaaaacttt cactaagatt c 201
<210> 677
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 677
gctcctctca actgcattct gagagtaggc ctgtttgaac agaatgcaaa ggaaaaaatg 60
tccatatgaa tcgccagggc agtcttgctg atttaagttc natagcaggt cctgaaacaa 120
ctccaaaact caacttcaat acctcttacc tgcagtttga aaagagatca actgggagac 180
atgtctgcct atggccccag a 201
<210> 678
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 678
ctcctctcaa ctgcattctg agagtaggcc tgtttgaaca gaatgcaaag gaaaaaatgt 60
ccatatgaat cgccagggca gtcttgctga tttaagttcc ntagcaggtc ctgaaacaac 120
tccaaaactc aacttcaata cctcttacct gcagtttgaa aagagatcaa ctgggagaca 180
tgtctgccta tggccccaga g 201
<210> 679
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 679
tggtccactg tttagcttgg aaagattata ttgtgagaag gatggcaaaa tatatataaa 60
attaggggaa gtttctttct aaaggcctct gtatttctgg nttaagtcta attgttcttg 120
catatctaag agcatgttta caatgtccat ttgtcattca gcagcaacta agaacaatat 180
ttatgtaggt ttacttagaa c 201
<210> 680
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 680
tatggttttt atttctttgt ttcctttatc tcagatattt ttgtgtctgc tgaatgtcta 60
agggagtgtt ctatggaaaa caggactaat aaatctccaa ntaatcccaa ttgttccaag 120
gactaatgat tgactatcca tttaacagat gacccatttg tgcaaaggca attaatcaac 180
ttttcatcga gtcttataca a 201
<210> 681
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 681
gatgctaaga atgtatgcaa acttgttaaa actatctttt attaaaaata aggacatttt 60
caaaattacc cacctttttt ctcctctact cacctccaaa nttctgttag cactactgga 120
atttttgatc taaggactca taattaagta atcatttttt attttatgtg gtttttcttc 180
taaaatttat ttttctatta a 201
<210> 682
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 682
attaattttt ttgataatca tgcaggaata tttgctcttg aatcatatat gaagtatatc 60
tttgacaaca caggccacca aaatttaatt agtgactgaa nagtgttgaa taaatatgtt 120
tgttctacaa acggaaaaca attttttatg tctaaagctt taatggaatt gtcacgaaat 180
ataattcatt ttttttcaaa c 201
<210> 683
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 683
tggttatcat gctttttgct acaagcgcat tttgtagttt taatcaaaaa cagttgtttt 60
gcaatgctca tttatcttat tgttctttgt tttttaaata ntgtctttgg ctgatttctt 120
aatatttaag tagctaattc acagtcacct ttctttttct tttactgatt tcatggtgtt 180
tccgtgctgt aattgtagag g 201
<210> 684
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 684
tgtatataac aaagcaactt atttttgttt gttgatttta tatcctgtaa catttctgaa 60
ttcatttatt agttatataa ttttttgtga aaggatttct ntttcttcac tcacagaaat 120
aatttgtctc tcacagttac tgctcaaaga ctgattatag gccacccact caattggctt 180
ttcctccaat atactgaatt g 201
<210> 685
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 685
gtcaaggttg tgctgatgac tgcctgtgca tgtcccttac tatgtgatca atgataccca 60
agactattca tattctactt ataccatttg tgggaacagg ntggaaagtt ttatgtagat 120
aatgttaaga agtttgttgt tgttgttgtt aattttcttc tgtctaatct gagaactcgt 180
tacccagtaa tctctcagga a 201
<210> 686
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 686
gattcaaaga gttgtttttg aagacacttt agcttcccaa gttgggcaga tggcctaaat 60
cacctcttca tcaggagcct tatgtcagtg tcaactttga nttatctgag ctttatttaa 120
gaaggtagca ttttctttcc acttgagtat tctcattgag ccttcaaatt taaacagtaa 180
aaccaatgga tgtgtctttt a 201
<210> 687
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 687
ccccaaagta gagactttat tggtgcagta aatcattttc aggactactg aatttcttcc 60
ttcatttctc catgataaag cagtacttcc tatttagcca nggttttcaa caccaaaaag 120
caattccagt atttattttt aggaactctg taaattctgc agatatcaag gaaaagatgg 180
tggtgtgtgc ctcttaaaag a 201
<210> 688
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 688
tttgcatatt ttatcatgtt tacagcacat ttaatcctca aatatctagg gataaacttg 60
aaactttata tttgaatgat taaagaaatg gagaaagggt ngtgacttcc ttactatagc 120
taatagtttt aatagtatct atcatttaat gagtaattgt aatatatcag gaattctgct 180
acttgattta tatatatcat c 201
<210> 689
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 689
tattttaatt actgtatgct agacttctat atctctttgt cattattgat ttttttttca 60
tttggctttt atttggtacc aactaaatgg aatattttct nagaagcgaa atacttctag 120
atcattgcag tctttaacaa tacaagcaat attcaaccag ggatttataa tcagagattc 180
ctttgaattt cttaattctg t 201
<210> 690
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 690
agttaaagac cgtgtctttg agctctgaat ttctttcttc tactgttaat tctattgctg 60
agactttcta gagaactttg catttctata agtgtgtcca ntgttatctg tcttctgggt 120
ccagtcacca agcaagtcta ctggctctgg gctggtactg ggggttatcc tgcacagagt 180
catgtgatgt gaaccatcta t 201
<210> 691
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 691
gaggaaaatt acccataaat gcagaaattc aaggcattta tggagaaaat gaatgtgaaa 60
taaaacacag agagaattcg tggagcaagt ttgtggtaga ntgaaagcaa atgaggcaaa 120
tgtagcacat gaagccataa tcatgagttc tcaggactgt aggtagcagg gaaggtctac 180
taaacaagtc taaacattga a 201
<210> 692
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 692
ctaagagcgt gtctttattc tttgttacaa aaatctaaag taaaagggaa aaatctcttt 60
aatggctgct gtaactacat tgcttttctt ttatgattgt ngtcacagaa aatgtaaaag 120
actttttttc ttaagacaat tcttttcatt gttaaataac atttatattc tactagcctt 180
ctagaaggaa aaatgcacag c 201
<210> 693
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 693
aatctgggag agcaaaagca tttattgcct caatattttt gcctgaattg ggttatattt 60
tctcaaacct acttttatct ttcagcctta tgattactct ntaagaaacc aaacatctgt 120
agacttacct tcatatacaa acttcaattt aactgccact agcaatgcct ccatatttca 180
aaaaaggagc tcttcttctg g 201
<210> 694
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 694
gcctcccaaa gtgctgggat tacaggcatg agccactgca tctgccttgt tttgtaagct 60
ttagacactc ctgtgctaca gcagcttcca tatgaggctg ngtttcatgt gtataagtta 120
ctagctcaga aaatccaaag ctaaattcct ggttgcatag tattctagta aatgtatatt 180
ttatgattta tttaaccaac t 201
<210> 695
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 695
gtcattgttc attgttaagg acattcacct tttcatggct ttgttctgtt agatgaaagt 60
gtttctagat ttggcattta tctaacatag catcataggg ngaatggaaa tgctgacagt 120
actttatagg aaatgaactg ctaccaacta tggcttgcca ggccctctag taggtaattt 180
acatacatga acacaaactt g 201
<210> 696
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 696
ttacctatgt ctgaaatata ggaagtactc aataaatgtt tggggaaaga agagaaggaa 60
aagaagaaag aaaaggaagt gtgctctttg ttagttttcc naaaaatgcc tcaagctaat 120
taatgcaagg gaattcaaaa taaaggtcag actggaggtg aagcaaaatc tgtatgtgtc 180
atctgtggga atcaagtctg g 201
<210> 697
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 697
cttgtcatta ctctactttc cctgcttttt tatacaccac agatggctgg ctgcatattc 60
tcttcctttt ggccttgcca atgtgggatt tctaaaacaa ntgatcatgt ttcatagcat 120
gttcataata atcattaaaa tatcactttc ctttactctc cattctacat gtagctgaga 180
taaatgctat ttaacctatg c 201
<210> 698
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 698
ttataccaat tttgtaatta tttatttctt tatggtatga ggctattgtg atcctgcctg 60
gagaatgatt atgacattga agaagttatg ctttgacata nctaaacctc cttacagtat 120
cctttctttt tgctgcctca ctgtcatgtc caagaacctc ataaagctca taaagaatgc 180
taaatgcagc tttactcaga c 201
<210> 699
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 699
agataaatac agcatggatt tttatataaa tatttgttag aaaggcaaat tttagtgcct 60
aatctgagaa attttagtaa aagaattaca ttataaatta nattaaaggt caacttcatc 120
tgggaacttt gtcagagaat aggacaaagg gccacccact ttgacttgag tcagaaattt 180
ctaagttaca atgaaatagc t 201
<210> 700
<211> 201
<212> DNA
<213> Homo sapiens
<400> 700
aactccaacc aagagtttgt gggaggcata tcccattaag gtgacattta agatggcagt 60
tttattttga ggaatctctc tgttttgtcc agatcaatgt ntttaacttg cacagaattt 120
gggaataagg caacgcctag ttgggggaga catatagaga agaagagaaa agtgagagga 180
gcgtcaaagg cctattgtag g 201
<210> 701
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 701
ttgacattaa atcacataat attcagactt gtaaaaacta acaggcatat tatgcatggt 60
cttttagtaa ttatatattt ctaagcacaa ctacaactac naaccttcaa atccaagaga 120
taaacactta tttatagtac aattttttgc ttttcttttc tctcgccatc accccagcag 180
tacagacaaa cccatcatgt a 201
<210> 702
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 702
ttcagaaaat tcttatcctt ttcctatata tgatattttc tcacttctgt tttaaagttt 60
gtgtaatctt ttttctttgt tgcattcacc aaacttttac ntattttgcc ttttcaaatc 120
atacattttg acattttcaa agagtgtgag tatttttagt gaagtttagg gagtgagagg 180
gctaaagaga gaagacaaca t 201
<210> 703
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 703
atttatcttt tgaaccttat tctctcagca ttctcagatt gctcattctt atggtctata 60
taatcatgaa ccctactcta gggcagtgaa agagttatac nattagaatg acctgggaac 120
tttttctaac tagacatgcc tgccttcact tcctgcctcc catatagaaa accccctatc 180
ctagttccaa taggtatgag a 201
<210> 704
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 704
tgaacctaga aaagaaacct gcccccatct cacaaaccac agagcccatg actgccaggc 60
ttgcatgcca agataattgt ttgtctgtct gtagctgctt ncagtagccc aggtggtaat 120
actactcaga cctggaggtc agaacttccc ctccaggtgt gttacagaat ccttgacata 180
aacagcagct cagtacaaga a 201
<210> 705
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 705
tttgttctaa gctctgccag tattttgtca catgatcttt catacaccag ttaacatcca 60
cttgggaatt gagtgctttt tgagctccta aacagggaat natgtttttc ccattagaaa 120
attattttat gaaaatattt ctaagttcct gaattagaag gatagatttt ttaaaatgtt 180
ctatgcaaga ttatgtctag a 201
<210> 706
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 706
gaggtaaaac ttgaaagaac ataaaagtat tgaaaagatc aggtcttgtc tgatccatta 60
cccatattca tataaataaa taaatagcaa aatcagcaca ntcaacaatt tcaaagatgg 120
tttatttcaa gaataaaaat tttaatgtta cttaaggtat ctcaatttat aaagagagat 180
gtaaaactcc tgttcatttt a 201
<210> 707
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 707
cagtgtttaa attttaccta attctaccac cttatggaac attatttctt atgacattgt 60
taaaaagcag aaacaaacaa gacgaaattt aaaaaaaaaa ncccaagaca aaatggcatc 120
aactaattcc tgcattttat ttttgcagaa atggatctaa ataaattaat tttttatgat 180
ggactaacag gtaaagtgca g 201
<210> 708
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 708
agggtagttt tgtaatttct taattattgt gtcaaagata aaatgaagaa agagtgatta 60
tcatgattag aattgttcag gaaagactca actgtttgca naagacttag cgatacaact 120
tacaattcaa ccaacagtta aggttttcga caggaaaaaa aaaattctgt tctccagtac 180
tggagacaca aatgtgagaa a 201
<210> 709
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 709
tcaggctgtg gcttctttct cagctcttaa aaagactgta atctgtctca cagttgtact 60
gcctgattgt tagttggctc tattcaccct acctagatgg naactaaccc tttcctgaca 120
ctttgaaaat tctttcattc ccttggtttt agttacctct ctcgcacgca caccatcatt 180
attctactgt tctttattta t 201
<210> 710
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 710
taggcctcag tttctgcata cagcatctta tttaatgacc acaataaccc tataatcttg 60
gatctgtctt ctccactcat actcaactga gacaatccaa ncgctttact tattctcaat 120
ttaaagtcat acttactagc ctaactgcct ccccttccat ttgcaaaaat gtgcaagttt 180
acgccatagg gttgcaataa a 201
<210> 711
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 711
gaaggatagg gtgtattcaa tattagtaaa gtgctaaaga gaaacatgac tctgaaggcc 60
tctgggcttt gaaacagtaa atatatgtgt gctttttttg nagcaagggt ccttaggttc 120
taagtattct gtaacacaaa atttttttat aaactattta actagacatt aaggatggca 180
ggaataggac agactaaaaa a 201
<210> 712
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 712
cttatggtac ctgaaataga tcttaagctg ggcaaatcaa gacaactgaa gaactttcta 60
ctctagtctt cttactccct ttatcctcaa agggtattac nttagcagga atcaaagagg 120
gtctcctgct gttggcaaaa ctctgggagg tagaaagaaa agaaatggca agcccaagac 180
caatctccct gctcagagga g 201
<210> 713
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 713
tctaacactt ccccttctct cccattttac agatgtaaag taaacttcac ttcccagaga 60
agtgaagagg tgagtccaag gcagtacact cttaagattt ntggatcaat ccatccctgt 120
tttgtttacc aaccaccatt aaacacacaa aagttttatc aaggcacaaa taggatatca 180
aaacaattca agacttcagc a 201
<210> 714
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 714
ccaccattaa acacacaaaa gttttatcaa ggcacaaata ggatatcaaa acaattcaag 60
acttcagcat cttctgagag ccgagcactt gagtacccac ntggtgatgg ggaaaagtaa 120
ggagaaaaca ccatatgggc accatcctga ttatgaaact ggcccaattg tctcacagaa 180
ctaatgtttt tggtttcttt t 201
<210> 715
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 715
tagaagacct ttttcacctt cgcccctctt cggctcctcc tcgccctcct ccttttccaa 60
tcagcctgcc tggtgacatc cgagctgagg gatgaatagt nagcaaggag ttcaccagca 120
aacccttttc aacagtaatg aggcatttgt gataatcgag tgatgaaatg taaatgggca 180
gtaatgagca caattacatc c 201
<210> 716
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 716
aaacatacaa gcttagaatt ggctcaagtt tattttataa taattgaata gtcacagtta 60
gaggcacctg tgacctgaaa atgctggttg aatggtattt ncgtatttac agagcagata 120
ccatagctaa agtgtatttt accagcatta tcaaatattg gattcaaagt ctcttttaat 180
acatttctga taaaaatata t 201
<210> 717
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 717
aggaatagca gatgaggctt gtgtgcttct agcaagaccg catgagagaa ggtggtaatt 60
tatctctcct tctttatgct gcagagataa agaagaactg naattaatcc actcaagcat 120
atgaggaaga gaaaacttag tttcacaagt aatcaaatta ttatactgtc ttgtaccagt 180
acatcacagg aaacaaattt c 201
<210> 718
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 718
acaatacctt aggaaaggag gcaaagaatg taaaaaccac attaatccat tgcacaatgt 60
tttttaaaaa agaaagaaaa aaaggtatta ctctaagtcc ngctttatta ccatcacaat 120
caatagaaac aaatttgtag tcacagttca ccttaagtga cactaactaa aaagaaaatg 180
gtgtgtaatt aatgtgtaat t 201
<210> 719
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 719
tccttggtgt cacctcccag gctccagggg agcacccact gctcttttcc atctcacttt 60
actcagaata ggtgctcagc ccttttaagt actgcgtaag ngtctccgcc cagctggctc 120
tcagacccag ttgctggctt gcatgcacat ggcctgctac agatttcctg cagccacagg 180
aatggctcct ggtaccttct c 201
<210> 720
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 720
agttttgtgg tgagggctaa gaagggagag taataggagg tggagaagga ggagccaggc 60
aggtaaatga aaaaggaaac gggttccttc tccgtgaaac ngagctagac gagcagctga 120
ttccagaggt tgtgacgatt ctacagaaat gcatggttgg ggttctcagc ccagcgacct 180
ccacggctct tgcctgtcag c 201
<210> 721
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 721
gtgataatgc ctgtgtcatt gtgtttttat gataattaaa tgagttaaat ataaacagtt 60
ttagaaaaat gttgggcaaa gaggaaaaca tttggtgaac ntttttatct cgcttcatca 120
tacctgttgc tgttggctcc taggggcaaa ccttgagtta agccccacta tccctatttc 180
tggatatttt aaatcatgtg a 201
<210> 722
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 722
acaatcagat cttccgatgg gtgggaggaa ggtgggagag tcagatgaag accacttgtg 60
tccaaattct ccaggagctg actggcctga aaaccacatg naaccttctc ggtaaatttc 120
ctcacagcgt ctggaaagcc gcgggcagcg aaatacacct caggtctgac ctcccactgg 180
ctgatgatcc gcaagattcc a 201
<210> 723
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 723
tttaattatt gcttgtgtca tttgtcttct actagcccct gtggacccag tcccctgttc 60
ctgcactctg ccctaagccc tggaagttga caaaaagaac naaaacctct ccccttgcct 120
ttgcttcgtg gttgagtttg gccatcgagg agctctggtg gagatgtgaa gaagggagag 180
taaggtcaag gtattcattc t 201
<210> 724
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 724
gactcttgat gtgaagacgg ttctagggcc atataaacag agtttttgat ctaccaggaa 60
tagttggtag actgggcact tatagccatg attgaatgtc ntagcttgca gagcctgttt 120
gattgcggaa acagaaactc agctcatgcc ggcttatggt ctgacatcag actcagctgt 180
atccagagct caaactcacc a 201
<210> 725
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 725
tagaagacct ttttcacctt cgcccctctt cggctcctcc tcgccctcct ccttttccaa 60
tcagcctgcc tggtgacatc cgagctgagg gatgaatagt nagcaaggag ttcaccagca 120
aacccttttc aacagtaatg aggcatttgt gataatcgag tgatgaaatg taaatgggca 180
gtaatgagca caattacatc c 201
<210> 726
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 726
ccttacctta ttaagtaggg taagtattaa gtaataagta atttttcacc cagctagaac 60
tgggagagaa tgtgtgcact attgtatggc cccagaccac nttggcactg accgttctct 120
ttcttcccat tccattcccc atgattgatc ctgttgggtg taaaatacat aaggaacaaa 180
aagctgctga atctgggggg a 201
<210> 727
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 727
atctaagact attcgagctt attgtgctgg ttacctagtt ctataaagga ttatgagttg 60
cccagttatc attttcctaa atgtctatca ataaatggag nccgagaaag agttcttttg 120
gggcagaaag aatgctatag ccacatgtaa atatccaaga aaccatggaa gctgcaatgc 180
acattctagt tttaatataa a 201
<210> 728
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 728
actgatctaa ttttgtaaag tggataaact ccagagggat gtgatagatg ttgttcatta 60
cacataggta ggtttgggca aaaatcattg attttgaaat nccaagattt ttttcctggt 120
accccaagga agtcttctag aaccaataga aaacttgtag acagaaatac aagtaaaaga 180
gtccacccat ttgtatgcag a 201
<210> 729
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 729
tttattgcaa taccattttc ctggtgagtc agttgcttgt gcagtgggca ggaagaacct 60
gttgggtgat cacaattaca gtatacccta acgtgaaata naagcactct agtaggataa 120
ccatatttca ctttagtttt cacctctgtt ctcatgcagc tgaggatttg ttggttgtag 180
tttgaggtag tggtcccagg c 201
<210> 730
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 730
tatttgttta aacaataaaa tgacaaccca tatgtcaaga tgatcacacc acaagaggaa 60
tgcagcgagc tgacagttga aattacataa tttaaatgag natctgattc caaaacagtg 120
tatgagaaca aagtgatttc tttaaaataa tttataataa acactaaggt ttgaacgtct 180
aatggtccaa aatattcaaa a 201
<210> 731
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 731
attatcctct atttttatta aagcctcaga ttattaacat tgcccatgat gtgtcattgt 60
ccaatgagat aaaccgtgtt tatatcttac ccaattcttt ntaaggtaca ttccacctag 120
aatgactcat ttttttcttt tgtgttattt cccctcttaa tgcgtttgca tataacacta 180
ccttacgtaa atcacatgct a 201
<210> 732
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 732
tgtaaaaacc tatacatcca tctccatggt ttttatagct cccaccatgc tgaccaccat 60
atcactggca acactataat tcagggactg gaaaataagg nagaggtcac ctccttcagc 120
atcgtttatg atctctccat tgtcctgttt tccaagaaga ttctggacac tgctctaata 180
catctagtac acaccacact t 201
<210> 733
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 733
actacaatca cttcaaacaa catagctcca aaatctgttt caatagttgg aaaactggtg 60
cgtttccata atttacacat gaaattaaac aaatgatttg naatgaaagc ttcatggcat 120
ttagtaagac ttagttcttt aaaaaaatta ttaattgaac agttggctga gtttattata 180
acagtccttc cccacatcta t 201
<210> 734
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 734
aaggacagaa aaagtatttg ctctgaaaac tgaagaagaa aatgtttggc tcagttcatt 60
ctttctgtaa ttccatggga attttatcac agaggaagaa nctagccctg tcgtatttct 120
ttatgaaaca ctattctatg tgtattttta aataataact aaaaatactc ttcagagaat 180
gttagaaata attcataaaa a 201
<210> 735
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 735
agattccaga attctctgct ccaggattcg ggggatatgt tgttagactc tttgagcctg 60
gaggcaatta gcaggagacc agaaaaaatg aagaggatcg naatcaaatt gtaaaagctg 120
aaaccagcca gaaatgtgag gttgaacgtg atatttttga aagagaaaaa tatataatat 180
aataagaaac tgtctcactt g 201
<210> 736
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 736
tggtgtctgc aagttggaag ttgaaactat cttttgtata cttcttttag ctattatata 60
cttgtgccta tttatttctc agtaccagaa aatgtgttcc ngaagacata ttcttcattg 120
cacagttcag agaaaatctt gtatcctcat tgttgaacat tcaaaataat agtgtgatta 180
ttctattact gtacttgata g 201
<210> 737
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 737
gaatttcaat attatttgat agtttcattt tattgtatta aaactctgaa aaattatatt 60
attagtaatt caaattggat tttcagggca gcctatggtc naaagccata aggattttat 120
cttgagaaca aaattagatc atgattttac atgtacagac atatgtgtgg gtataaattt 180
gtaattttta gtcagtattg c 201
<210> 738
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 738
aaacattcct ccgtagtaat cacaaaaata acagtgaaaa gaaaagaatg aggactttgt 60
agaatccaga ttcaagactt actctatatg ttgctgttat nattatccag actcacatgg 120
attcacaaga gtgaaccaaa accacaagaa actatttacc acattgaata ccactttaca 180
tcctcatcta aggaagatca t 201
<210> 739
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 739
ttgctctatg tgatactgtt tagtaagata tattgaatga gtgaataggt gtatgtaaaa 60
aaataatatt tatttttctg agttaaatat tctcatcaag naagtatttt gctctcttct 120
ctcaggcttg gacttaacct gttactgtcc tgcttgaata ccttttaatg tatttaatct 180
tttctgctgc tttgtttatt c 201
<210> 740
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 740
aacggaactc agagatcaac tcagatttct tcagtccgta aaactaagat gaacttttgg 60
gttcattact acttgttgtc atgtagatgt tcaattccaa ntcaagagtt ctgtattcca 120
tgtgattaaa taattctatg tgattccaca attaaaatgt ggctgcaact gcattcagtt 180
cagtcccagt cttacatggt a 201
<210> 741
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 741
attaaatata ttacagtgac caataggtat gtcattcagc actattagat ttcccagaaa 60
atattaaact gatctttgaa cattatattc cagtgtccca ngatataaag aaatgaatga 120
aaaataactt gaaacacaga tgctgctaga tgagagaaag aatatgataa aattggagga 180
aaataaaacc atagctgtgg a 201
<210> 742
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 742
ctaggataac agaaaacaaa caaacgaaca aacagacaaa aattttagcc cctgtcctaa 60
caatgtcatt ttttccgttc aggtgcagga tacaaattgg ntgccttctc agggcctctt 120
cattcctccc tcctccttga ctccttggct gattcccatg gaagcgaaga ggaagagcaa 180
tttaatagag ttattctatt a 201
<210> 743
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 743
gagaacattt tatgtctata gtaaaagaga agagaaaaca ggaatatcag ggtaattctt 60
gctagcccaa cctacacagc taaatttctg gcaaatagta ntggtataga ggcagagctg 120
gcttcatggg tctatgacct atacctttac gcagattgtt acgtttggtt taattgcttg 180
tctcttgcca tactgaaatt c 201
<210> 744
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 744
tcaaccttat accttacaaa ctgacaccta attttagtct atgttcagat tttatataac 60
ttttactctc aatatagttt aattgtgata atgaatcaaa ntgataccta ggttaaacac 120
ttgttagttt tcctattcat tttattaatg aaaactttaa cggtgacaaa gattctaaaa 180
ttttaataga gcagaatgtt t 201
<210> 745
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 745
tggtctagaa agaggccaag aaatttgtaa tgccctccta cgataccaag aagtcactaa 60
aggaagtcac taatttcctc ctttgtcctt atcctgacac ngcacaaaga cagaactttg 120
aaacataatt tggttttgaa acacttaatt accttcccca ttgatacaaa gggaaagatg 180
aaacccatat aacagcttca g 201
<210> 746
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 746
catagtgagc attcttcctt gtaagatatc tgcaggggtc tcagtggtct ttagctgaag 60
agcattgaca tttcctagcc ctttaaaaaa ctggctgtcc ntaattggta aacatgaata 120
actcagttaa taaaatgcta aattgacaga actcccattc tccaattatt ccagatcaat 180
tatatctatt agctatacca a 201
<210> 747
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 747
accagtccta ttccaatcag ctgtggtctg ggtgataaat ttctgtggtg taaaacatga 60
tgatctaagg ctgcctctac agaaggagct attttgtgtt ncatgaatca cttgtaatga 120
ccagattgtt gaatttttct agttgaagat ttgacaacac catttttatg tctgctttta 180
atagttcatc cctatctgtt t 201
<210> 748
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 748
cgcaataaag ctattttgga attagacatt atttatttgg agagagtaga tttatcacct 60
tgcttcacac tttctacttc tgatctctct tggtttgcct nttagctttt gggggagtat 120
ttctttttga taatcatcgt tatctactta tctcagtaat aaagactctt gcactgtttt 180
aacatgttag atggttagac t 201
<210> 749
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 749
agagacgctg tctcaaataa ataaataaat aaaaataaaa aagcaaacag attcagaata 60
ggttttacct cattttttag aaaacccatg aacccaatgg naatttaagg gatacaaatt 120
aatacagaag aaagattctt tgagaaacaa cagtgcctgc tgccaaacaa ggaacatagg 180
aaaaaaaaaa gaagtcaaaa a 201
<210> 750
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 750
aggtacaatg gcaaaacaca gttatgtcaa taccatttat gaagaacaaa ttaaaaaaat 60
acctccttca taaaatcaat agcaaggcag agaaaatcaa natgaatggg caaaggagag 120
taggtaaccc ggataacaaa tgagtggaat ctgagcgcac acctgcttga gtgagcatag 180
gtaaacaatt actggctgaa t 201
<210> 751
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 751
ctgcagaatg caagacactg tggcatctta caatagttac aaaggcatta gcacaaggca 60
gatttatttg tttatttatg tcccctataa accacagcta nactgttttt tattgatttt 120
ttttttaaat ttgccttgac ctcttttttc taaattccaa aatattaaga ttcttattca 180
gcagatttga gaagttttta a 201
<210> 752
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 752
cttacaatag ttacaaaggc attagcacaa ggcagattta tttgtttatt tatgtcccct 60
ataaaccaca gctaaactgt tttttattga tttttttttt naatttgcct tgacctcttt 120
tttctaaatt ccaaaatatt aagattctta ttcagcagat ttgagaagtt tttaaatgta 180
ataaagtggt tttgattgta g 201
<210> 753
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 753
cctagctata ggagtagaag atgagtatag atatcatgga gataaatttt tgtaaaaaca 60
aattttcctt tcaagttttg gccaatgctt ttgctgcata ntgttgcttt tcatattttt 120
attgttagca acatgataaa actatgtcag taagtgggtt agctaatata ggtagggtat 180
cctttatctg aaatgcttgg g 201
<210> 754
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 754
ggccaaaagt ttttccggaa gcttgtcctc taccttgaag ttgcctacct tttcttctca 60
ccacatacca gagtgcaggg ggtggccttc cagtcatatc nttctcctct gcctcagttt 120
ccctgtcttt ggatccatta atagaggaaa agaaaggcag atctcattga tggagtggaa 180
tgatactttc ccagcagtca g 201
<210> 755
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 755
agttttattc ccagtccaag acgatccttc atcactattt tctcattgga agaatgattc 60
cccttcattt ggaagcaact ggcagatgtt ccctgctgag ntggctctcg gttttggtgg 120
aatgctgcgg tgttgaaatg ccacatgtac aattgacttt tcttactctt cccactcccc 180
gttctggaaa ttgcttccac t 201
<210> 756
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 756
gcttacggtt atttgattgg taactcaaat gatggatatt gccagttgtc tcctgtgaga 60
gagttagagg ttacttaagc tatgattttt catatcaaat naaaaaaaac ctaaacttct 120
gatggctctc atttgcctat atttcaaact tgaaaagaga atgagaaaca ttaaggaaat 180
gatataagtg tgctttgtcc a 201
<210> 757
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 757
atgctcttat cttcttattc tctgtgtatc tgtgtcaatt tgacttttat tcaaacttct 60
caagagagga tccaattgag tgggcttgtc cagtatttac ntctcttgct gggtaatgct 120
tgtgctgagc caggtgatag gccactggtc tctctcatgt caaactttgg gacacacttt 180
gattcatggt ggccagactt g 201
<210> 758
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 758
agtgttgctt tctcccaaaa gacctcctcc catatgcagg ctctttcaac atcactcagt 60
caacatactg tgtctccttc tagcccatct cctgccctgt ntcttattaa cattttgcct 120
gtcacactct taatttctct attattcctt tctttctatc cagcttgtct gtttgtaaga 180
actattctat atgcccactg c 201
<210> 759
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 759
tccctaatga ataagtgatt gggagaattc tttgccagaa tttgttaagg agaatatatc 60
taccgagttc cagaatttat acaattcttt tttctgaatt nactgatcct cttgttttta 120
tttagataat ttaggattca cattgttcca ctgaatggtc aatttcttgc ttcatatctt 180
ttaacatcca atgcagaaaa t 201
<210> 760
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 760
gttttacacg tggccactta actgatgaga aaaatatctt ctgaggaata tgtcagccag 60
taagtggaaa ttaaatcatg acaaactgga gcaactgttc ngattattca ggtaaattta 120
aagcaagtcc atatgcaagg gaagtgaaac acattgatgt tttagattac ttaaattaaa 180
aaatgttcag catgtgattt g 201
<210> 761
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 761
tatatccacc ttcaaaaaga gagaagctta attgttaata tgcctcactc tgtggtgctt 60
gactatactg tttcatttct ccctcttgat agtctagtga ncttgaagga ggctggatct 120
tcaagtacgt tgaacaatgg gcccagctgt gagccctgga gagagtaatc caggtatgag 180
tatgttgaaa atagcaaacc a 201
<210> 762
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 762
ctctctgtat aattctagat gtttcgaatt caagtttatt tatacataaa tgcgttattt 60
ctaaagacta gacacttgtg aaactgaatt acaatttcct nttgaatccc ttcatggagt 120
ttcttaaata taaatccacc tcaatcttat gtttcattgt acatatttaa ctatataaac 180
agtgtacaca tgttgattat g 201
<210> 763
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 763
ctgtgattaa agttccttat tatcaaagtt tttggttgtt caagtttaaa ctaatgtaag 60
tttgaaaact ccaaattata aaataatttg tggggctcac nttgtttcaa agattacagt 120
aatttatttt gcacatcact tttgaaaacc taaacctctc agtataaaca taataacttt 180
gtaaataatg tttagttgat c 201
<210> 764
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 764
ctgctcccag ccttcattta ttttaaaaat gaatttgaat aattagataa ggaaggtctt 60
ccagaagtaa taaggagaag taaagtaatc gagtcacaaa ntatgtggct ttggaattca 120
agtataacat gtatatgtgt atccattatg acaatatata ttgcatatct tgatagtatt 180
taacttaccc tggtttgact t 201
<210> 765
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 765
agaagctata tgtttaagca tagatgccat aaaaaggtag attatttcat ttctcaaatt 60
taaaaatgtt gaaaactttt cttaagaaac ctattcccta ngatagtgtt attactacat 120
gcctgtttat ccctaacatg tttatatttt caagataatg aaaagaaaat ccccatctat 180
gccatgccac acttatagat a 201
<210> 766
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 766
aaggcttact gagattatat gattaactta ctctgcagtg gagaggagga gggtaaacag 60
aaggagattt gaccaacagc tgctgccaag ctttatgact nggaggagat aagggttgta 120
gatgtattta ttatcttctg tggaaagaaa aatgatcttc tgtggcaaaa ttcaatcaaa 180
tctacattat ctaattgaag c 201
<210> 767
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 767
ctgctgggtg aaaattagag tcattgctct aaggatatgc cctgcaatga gaaagaaaat 60
gtcatgctgg gaattacact aactcatata agttttcaag ngagtttaat ggaattttta 120
actaaaaata ttctcatttt acaaggtaat tcacaaataa aatataattc aaataagaga 180
attttggttt aagggcaatt t 201
<210> 768
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 768
tcaccaatga tggctttaca caagtagata caatgaaact tggaataaaa tattgcattt 60
actgtctaaa catttgtatc tagcccaagc acaaataaat ntactacttt ggcatgagct 120
tgaatcccag acatgattat gattcagatt acaccagaat tttaccagaa ttcagcaagt 180
tttctacatt ttctctcttc t 201
<210> 769
<211> 201
<212> DNA
<213> Homo sapiens
<400> 769
gccctaacat ccattcaatc tgcaaaccag gaaaagtagt catgataaaa atggcattac 60
taacatgtct ggagatattt ttagcttata agctcttgta ngaatgtatc tgtccactta 120
gaatatcagt gaaatgtagg tctgagaata taagcctgat gataaaaact ccctcatttt 180
cttgtacaac aaatctaaca g 201
<210> 770
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 770
cagcgattta ttgtccttgg aatttatggt cattttgtgg gcaaatgtaa attgccattt 60
tctttcagca caatatgtta taatttcaga gctatttaag naatgcacca aaaaaaagca 120
cagagagtag ataaatggaa attgctaaaa gtaattcaat aaataacaat caaagcagga 180
caatcaaaaa ggaaagtctt g 201
<210> 771
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 771
gtacaggaag attttctttg taaaatgtag ttaatagcag ctggttcaca tttttcctac 60
caatgtttgc tctgagaaat gctgtacata tatgaattca ngtagctgga catatgcatg 120
tatataagca tcacctgcta gcctgttgtg ccactggaac tcccatatac atgtatatag 180
aaaaatcata tcatcctgtt t 201
<210> 772
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 772
ttggcattcc taactcttct tttattcaca gtgacacctt tacttttagt cccacaagcc 60
tagggaatga cagcttaagg ttgtgggggc acctaagatc naaggagctg gtcacagctg 120
cttggagctg aatgccactt ggggctaggg cagcaatggc ataggggtca caggcctact 180
tctgatctat ctttaacatt t 201
<210> 773
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 773
agatgacaaa agtatatctt agtttaaatt tgctcagagt tgcataaggt cttttagaac 60
gctccaaatc aactctgatt ctcacacaca cagtggcgtt naaatgcaaa ttatattctt 120
aactattgac aaaaggccaa tatagagtac acacagaata agctatagca tggtttttgt 180
taagagtaaa agccaaagtc a 201
<210> 774
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 774
gtggctaaag aggtgagatt tggtgtatgg gcacatgtgg ggtgactatg gcactaaggg 60
catgggcatg catgatgctg ggaagggtaa cagctccagt nccaggaaga tacaatagca 120
acttcttttt gcagtatgtt ccagagggaa tagaacaggg atgactgttg gttacctcaa 180
tggcaaaaat tgtcaatgtc a 201
<210> 775
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 775
atcaatgcca gcatctaagc agtgtgcacc ttttgaccat agtctttcta attgaccaga 60
agcttagatg tggaaaatgc aaaaactatg cacatttctg ntgggtttaa cttctgagaa 120
atttttacaa ggttttcctt attttatctg ctccagtaaa cctgtggttt catgaacagg 180
cctagaattt gagattcagc t 201
<210> 776
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 776
ctagggataa gcaataggat tagcaatgtg ttctaccttc atttctcaag caagacttga 60
gccaattaac catgagcaag acggctttgc catggtaaga ngcacttgtt aacaattaaa 120
aatgaaaatc tctttcatat gactggatac agctctttaa ctcagtttaa tggagcattc 180
aatgtcaata taatttgatg a 201
<210> 777
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 777
ctagggataa gcaataggat tagcaatgtg ttctaccttc atttctcaag caagacttga 60
gccaattaac catgagcaag acggctttgc catggtaaga ngcacttgtt aacaattaaa 120
aatgaaaatc tctttcatat gactggatac agctctttaa ctcagtttaa tggagcattc 180
aatgtcaata taatttgatg a 201
<210> 778
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 778
atgtttctta agagtagtca ataacttacc atttagaaat aaattaattc tttaaaggga 60
atcaatgctt ccttgttcta aagtgaaaac acaaataaca ntctcactat ggattggcct 120
atatgcccat ccacatgtat atatgatcct gaaacttaca cagcagtaca gtggttttgt 180
ggggattttt ttttccttct t 201
<210> 779
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 779
atttacatgt aagagtatgt aaggaaatgc ttgtaatgtg aagggaacta ttcctagaaa 60
aaaattgaga agtaggacaa gtctcttttt gtgtcctccc ngcacgtcct cccagcactt 120
ccttctgttt cccaaggaag ccactatttc ctcattgccc aagttccttc ctataacagc 180
aaggaatgta ggaaatgaca t 201
<210> 780
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 780
acacccagcc taaaataatt attaatagtt aattccccaa tgggtttttt tggttattga 60
atactaagaa aggcagtgta aatgctagcc ttaagtcatt nggaataaac tgaataataa 120
tttaaaaaca cacatttaca gtttgtgaag actcacatat ctctggttta ccaaataaag 180
agaaggaaat aaaagaatcc a 201
<210> 781
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 781
gattgccaaa atattgttgt gccaaaaata gagttttaaa aaatgcatga gtgcacaaac 60
aaacacaagc tcatatacct acacacattc tgaggaatct ntgctctttc taggaaagtt 120
tttgagaggg tttttatcct tttacatata aaaatgtaaa atagagcact gtcatataat 180
ttagacagca acatttctta a 201
<210> 782
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 782
ctcaggcttg agaattgtaa ctcaacctat gaaacattag tgagctttcc tttactatgt 60
aactttgtcc tataatactt taggcctaaa tagtttcaag ntcaaacaga tcataaagat 120
atctctgtct tttaaaattg aacattcgcc cagcatcgac gagatagaac cggagatata 180
gagcaagaga tgaaaagttg a 201
<210> 783
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 783
gtggtgtaga aaggtctgtg aaatgctggc ttgctcctcc atcaccttcc acttgtgtat 60
gttgagagaa ttaaacaaaa ctctcatttt ggctgaaagt ngaacctggg tttaaatgtt 120
ttcaatctga accatgtttc ctaaataaat tcatgataac ttgcacattc aaaattaaaa 180
tcaaggggct aatttgtaac a 201
<210> 784
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 784
gatggaggaa tcccaactct gtgaatttgg ataaacccat tatctaaatc ttcttagtta 60
tttcgcagaa tcttcctaga tatctttcca tgatctttcc ngcctgaggc ctcttactgg 120
acccagttca ggttttgtta gacccaatct gatgttgaac ccaatatgac tttcaaatct 180
agtctggatt aaaaatgatc a 201
<210> 785
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 785
ctcttttcat tatcttctaa tttactatag gcatgtctcc taacaaaatt acctttcagg 60
aaaatttagt cctctgaaaa acatttctct gggtgacagt ntctcactat actttttaaa 120
atcaaggcag tcttgttcat atttacgtat tttcttctaa tacattcaga atgtttaaga 180
ggatcctaag aacaaaacta a 201
<210> 786
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 786
atttgtaatg tttattttaa aataaaatcc agattgcttt gttagaacaa gcatctatac 60
acagtaaata gctgaagtct tgccacagtc tcctcagctt ngctgctcct gagagaccac 120
aaacttgtcc tggaacatgt gtaacctaat agcccagagt ataacaatga tgacagggaa 180
tcagtcttgg tctcaaaata t 201
<210> 787
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 787
attgcctccc ctgatacctg gagccatcaa ggctgagcac tgtttctcca aaacggatct 60
gtgtctccaa agcttattgc atttccacag atcccggaat ntgccatgag ctctcttatc 120
ctcatatcct accataagct ctcatatcct catgccttgt tcagaactcg tacatctact 180
cgtatcccct ccctattgtt c 201
<210> 788
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 788
aactaagaat ccagagttta aatagcttgt caagcacatg cagtcaaaga tgagagtgaa 60
gttttcagca actttaaatg tgagagaagg catagtggat ngaaagacaa agtgtggatg 120
aagatgagcc agtgcgttgg tggaaattgg gtgattgcag cgagaaaaaa tttcataaga 180
ataaaagttg ctgaaggatg g 201
<210> 789
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 789
actcagaaga tagcatgcac ttatctttgg ctgagtctag atgctaggtg aattttgttc 60
catacatgca ctgctaggtc agctcactgg agaaatcgca nttgccatta aatatgaaat 120
gtactcaaag cactttcatc ttgacatacc ccaggattta cctaatatga aatgagatct 180
agaatctaca ttttgatatt t 201
<210> 790
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 790
ggttcattaa taggtacatt gccttttccc tgtaggggaa taaagactta agtaactttc 60
ctgaatttca gcaatacggt taaatttttt ttatgtctat nttaaatatt ttcttctatt 120
tacagtatct ttcacctctc tctcccttgc cccatccctc tctccctccc tccttccctt 180
tctctttctc tttccttcca t 201
<210> 791
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 791
tttcctttat cagatgtgaa taatcaattt taagacttaa atatgggagc aggaagaact 60
ctttaaataa aggaaatcaa aacaagctac tagaatcatg ncttggaact tttgaagctc 120
agataattag ttgactgctg ctgcctaatt tcataattgt gaaggcaatg gcactgataa 180
cagttgcaaa acattcacaa c 201
<210> 792
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 792
cattgaccag ctttcaaatg aaggtttttc ctagggaggg agcataactt ttaagtaatc 60
cctttcttct cagcagaggt ttattcctag agagtgattc ngctttgagt tttcggcaac 120
caacccctgc agtggcaggg agaatgagag actcattcag atgggagaat agtactgttg 180
aatcacagac gtactgagat t 201
<210> 793
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 793
tttagttttt tttttttctg tttagtcagt atctgcaatg atatttttag acatcagttt 60
tacctaaatt ttaaaacttg ttggtaaatt tgaagactta ngtattttat atttcttgtt 120
ctccaattat gcaattttca ttcttactac tcttcactca caatatctca ttttagtact 180
tattgttcaa atatccagaa g 201
<210> 794
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 794
tatatatgga ccacatttaa aatccttttt ttcaatgggt aaaaacccca aggaaatatt 60
ttagctcctt tcaacctatt ttaaaaacat caccagtttc naagtagcaa tgtaaaatga 120
atgtgcaatt aatagttcta agaaatggga atagcataat attttcactg tgatgaactt 180
ctggcattta aaaggacttt a 201
<210> 795
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 795
gactaaagga atgtttcttt ttttaaatcc atgtcagaaa atagtattaa aggagttaaa 60
gagtttttac tttaaactta tatcaacata tctaggttgc naaataccat acatagaaca 120
gaacacatag gcagtcggga gaggaagtca gatgcaaaag ttcttatatt attgtggtta 180
aactttgaag gggttgtgta a 201
<210> 796
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 796
ttagtcattt gtatggaggg gtgaggagtc aggacagggg ataattattt gctttttatt 60
tttatttatt taattttatt attatattgt aatctggacc ngctacaagt atgtgtatat 120
aacctaggta aaactacacg taggcttttg gcacctgtgg ttgcctgtca gcttagtgga 180
gctcctaacc atctaaaatg t 201
<210> 797
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 797
cacagcaaaa ccctctgctc acccacgacc tggagctcat tagaataaag caagtgaggt 60
gaagcctgga gtctggttca gcagtagcat gccatctgcc ntctatttgt gaccagaaag 120
cccatgcaaa tgaactacag agtgctaacc gtgtgttaat acacagttag taaagatgaa 180
agcgttccac cccatcttta a 201
<210> 798
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 798
tgcacgaatg gggttggaat gggtctttgg cagaaagcag tggcatctgt catctttgct 60
tcaccacgat tccagctcag caccaggcct ctggtagcgc ntttcctcct catcacattt 120
gttcctgttg actgaccaga ttattgatcg ctctgttctg cagcactggg tgggttaagc 180
ttggttgcct ccaggcctct g 201
<210> 799
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 799
tcatgtgagt gaattcagaa tcaagttgaa aagatgaaac catattccct tttaataaca 60
taaataacca ctgttattct tttatgttat ataaaattgc ngcataaaat aaatttcatc 120
atttgtagtc ataactttga atatcctttc tgaaacttaa ctttcccaac tcactctcct 180
aaagaagccc gcaccctcac c 201
<210> 800
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 800
ataccggatt ccagttgcac ctcacctcac ctgttctgtc ctgcagcagg tgattatcca 60
tgccctggaa tagttgagat gtggcagata ttaatttaca naggcttacc aatcatttca 120
aaccctatcc tggaaacaaa gtttgaggca aaggaggagt caaggcaatg gaggagctgg 180
caagtaaagt cattaggatt t 201
<210> 801
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 801
agtaactatc agaaattaca gaaaactgtt atctttgatc ctgcacccaa tgttagaata 60
aaacttccta atatctgaat tcacagatgt tctaattcac nttcagcacc accattgatt 120
tcttgggtat ggtaatatac aacagacact cagaagaatt ttattacttg caagcatctt 180
ttacacatta gttcttctcc g 201
<210> 802
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 802
aggcaggctg gcacattcga agctcacatt ctgttacctc cacagaacct ctggggacaa 60
tgacagtgtc agtgtgcaca gatgaggtca gaatgacgac nggccatctc acctaactct 120
tgcccatcag ctgttgtgat cgaaaatgta aaagtaaata gacccctttt cactgcccga 180
gtctgggtgg acctcacctg a 201
<210> 803
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 803
gggatgcatg ttccacacat ggcaatggat ttggagaata cccaaatacg attctgtgag 60
gatcatcagg cctttcacat cttcctgagg ggatgggatt ngaagaatgg agaaaaagga 120
gagaggagag gtgagtttgg agaatgtggt gtcttgagga aatcagctct caggtttggg 180
cagggagcca tatggtcctc a 201
<210> 804
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 804
gctccatctc cctccgagac aaagtgagac tccacttggg caacaaggac agaggctgtg 60
actctgtgga cacagatgga gggtgaagaa tgcaaacagc ngtttttcct acaatctggg 120
aattgttaga aagatttagt atttccacaa tgtctcctta ggtcagcgcc accaggctct 180
gggcacacag aaagggggct g 201
<210> 805
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 805
tgaggcaggc aagcagggcc cgtggtacaa atgtgctgag caagttgtga tgagaaatga 60
acacaagtat aatgaacagg aaggatttta aagatttctc naccatgcac actctgttaa 120
cctttgccat caatcaactc agagagcaga gatacatagc cctttgtcca cagttgcaat 180
tcccagaatg ggttccttag a 201
<210> 806
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 806
ggatgaagct gactgatgcc cacacagagc agcagtggtg ggaataaagg caagtgagac 60
tgagactctc aaatggtgca gaagagttat ctgacacagt ncacaccttg gtcattcaga 120
tctgctcctg ccctccgttt gagctgtttt attcacaata cttctgacac caaatgtgtg 180
attttttttc ccttatatcc a 201
<210> 807
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 807
ctgtatggat ggggagagtg tagtcagggt ggttaggggt aaggaagggc cttaactttt 60
ttatcctatg cattttggtg ttgctcaaac cttttataat nagacattca tgaactcctt 120
gagcattaaa gtatatatct gcaaataaaa tattgttctt gggaatggtg tatttttccc 180
ttttattttt taaataagtc t 201
<210> 808
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 808
gtaactccac acaacttcaa gtttacaaag tgttagttga accttaatct gtcaactcta 60
aactcatacc cttggtacaa tcctaggcta ctctcttagg nctaactgct aagagagagt 120
tctttgagag tagaagaaca gataggctag tcttttagga gttgttttag aataagaagg 180
tgtaaatgtg taagtttata g 201
<210> 809
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 809
attttgaatg tgattgggtt acttatgttt acaatgttaa tttaatttta gtattggttg 60
tagattatgg ttaaagttga ggcctgctgg acacatcatt naggagttct ggaaaagaca 120
gagaaaaaag atgacccaat ggtggagaaa tacacacaag ggaaaatcat gggctagcct 180
aggagataga aaatattggc a 201
<210> 810
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 810
taagatgcta tacataagtc atgatgacct gggcattcaa gctatcaaat tcttttaaag 60
tcttacccct gtgaggcaag gcagtaagag aatcccaaat nggatatgag tcatgactat 120
agaccaaatg ccttattatc ctaaaaagaa gcttaggcct tactagagac agtccctgtg 180
agctttctta tttctgtggg g 201
<210> 811
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 811
gaaaaaaaaa aaagaaagaa aattagaaag gtatattgta aattaaatac tccatgtaaa 60
cttaaaacaa cagatagatt caatattgaa atggaaatga nctaaattca actaaaatgt 120
aaagaaaaaa atgtatggag agaattattt ttgagggggc tatgtattca tatacaaata 180
tttccattaa tcactaacat t 201
<210> 812
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 812
atttgcataa tgtaggccta ttttctaata gttaacttgc cgcttattac taaggatgtt 60
catttccaca tcttttccag ccatatttag tttggaagtg naatcccatt gtgtatctct 120
aatatatttt tcaacataat acatctgcta gatttcaaat tacatttcag tgagtagttc 180
ttgtcttgta ttcaaccccc a 201
<210> 813
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 813
tgtgctgggc atcactgggt tctaatggac gtgggcagag agggtgcagg tcaaggtggg 60
gagttagaat aagaccagcc cctcagtgag gacttccact ncaataggac ccccgtctcc 120
catgatttac acctatcact catttaatct ccatagcaat ccactgaaac agacacaact 180
ctgaccacaa tttcatgtgt t 201
<210> 814
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 814
ctcctatgtt caattttcat ttaagtacct tgacatatat acgtatttat ctatatgtat 60
ttataaaata tatttaattt aaggaccttg aaattttccc nttttctgtc atttataaat 120
gacttatttt tatcctgtta atatatatct taattatata tatcttacgg cttctttgca 180
tgtcagagtt ttttttgggt a 201
<210> 815
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 815
cagtgagctg tgattgcgcc attgcactcc agcctgggtg acagagacct tgtcgctaaa 60
acaaaaaaca acaacaaaaa aaaccttaaa accttaacaa ngtcagtctt ttcctggtgt 120
ggagttcagg aaatgagatt caccccatgg gtcatgtgca catgtttgtt ctattaggaa 180
tgaaggaaca agaggaccag g 201
<210> 816
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 816
aatttagacc tgggctgagg agcagcatac cacgtctaga ctcccctcct ccctttctag 60
agaggcaggc actcctaaaa ctgccagtct gaaccccaag nctctggaca aactattgga 120
gagggctgca ggagcagata cacagccaag aggtctcatg cttacaacta ggtgctcagg 180
attttgccat agaacacagg a 201
<210> 817
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 817
tcagtataaa aaagtgtatg tgtgtgtgtg tgtgtgtgtg tgtgtatgtg tgtgtgtgtt 60
ttaagtttac aggtccatgg tttcaacact ctgaaaaatc nttgtattag gcatagagaa 120
ctgacattta ctgcgtgcca gtcaaatcat ttcatactca tgacaaccct gtaagataag 180
tatctctgat tcaaggtatg c 201
<210> 818
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 818
ccacccgtct cggcctccca aagtgctggg attacaggcg tgagccactg tgcccggcca 60
gtaagagctc acttttaggg actggtctaa aaaatatgcc nccctgtgaa tctatgaggt 120
gagtattatt actaatcata ttttacagat taaagaaacc acacagggcc aggagcgatg 180
gctcacatct gtaatcacag c 201
<210> 819
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 819
tagagcatac cacccaaatt tcaaagggag gtgtgttcct accatgttcc agaaggcggg 60
aaaaccagag tatttggtaa cagctctaaa gtttactaca nggaaaaaaa gaaaaagcct 120
ttaaactgta cgaagtggta ttttctttta ataatttcta gcatcaacac attctattta 180
acttctgcat aacattccat a 201
<210> 820
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 820
actggcgtga cctgacatat aatctcatgg gtttcatgga tctgtatccc tgggcattta 60
tgccctcact ctcctgtaca tctaggagac taagagatta ncacagaatg actatttctg 120
cctcagtctg gagcaagatt gaacaatggt cgtctgactg aagtcactcc ataaggagta 180
cctgtgactg tggaacatct g 201
<210> 821
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 821
gatacagctg tcctaatgat ttttgaattc cctttcctag aatgctgtaa ttgagatgaa 60
aactgacata attttaacat gttccaattc taaaatacaa ntttcccatt aaatgcaata 120
atcactcaga aatctaacta attaattcca tccactttgg aacaaagttt caggtttttt 180
ttccttaaaa agtcttatgt a 201
<210> 822
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 822
tgagacaaat agcagtctat tctcacctct tgttccttta tgacatttct aacgattatt 60
tttaaaattc taatatgtac aagttcatag agaatttcac nttttcaacc ttatgacatt 120
caattcctgt ttaattttta aaaattcttg atgcgtagcc ataatctact gtaattaatt 180
tcattccatt tctagaagaa a 201
<210> 823
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 823
atttatattt gcatatattc aaattaaata cattttattt gaacatttct gcgacagagc 60
taggcatcac catgtgttta aaatgcatca cattttttga ngattatgaa tgttgtcaat 120
gttgtaattc tataacatac ttaaaataaa tatgtgaaat gcatttcatt aggcacacaa 180
catatgcagc cgacggaaaa t 201
<210> 824
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 824
ttttggtcag gtcagtttga atgactcctc attgttgatt acaaatgtct aaataacatt 60
cccatctatg cttacaatgt cagcttccct attaaccttc naaaatgatt tgaagaaaaa 120
gcaattcaat catttctatt ttgtaccacc aaaaaaaaaa aagagagtac tgctttgtag 180
tatgaaataa gtttcatctt g 201
<210> 825
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 825
aattttgcat cttaaattta ccagtgaggg ctcattttca gtcaatatct tcacacagtt 60
atcatcataa tcaagtccta aattacaatt ctccgtattt nagttatatg tcataaattt 120
tcatttttct gggtttgggc tttagctgtg ctataattgt cttgactttt ctctatatct 180
tcatattata tcttaataac a 201
<210> 826
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 826
ggcaacaaaa gccaaaattg acaaatggga tctaattaaa ctaaagagct tctgcacagc 60
aaaagaaatt taatgttttt tcaacatatt tcagttaaac ntggcttacc tttataaaca 120
gcatatttat ttcaagctat aaatatgttt tataatctgt aaatttttag aaattttaag 180
tctagcgatg aagctttcat a 201
<210> 827
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 827
atgttggaac agaatccata atgggaagac taaacactgt taatactccg aagtttggtg 60
tcaacctcct cttagctgca ttttttaaaa ctatgtctaa ngagccaaca gttcattaag 120
acatcatgag tcatccattc ttttcccttt ttcctttacc atcatttttc ccttggcaat 180
agagaatata attttaactg a 201
<210> 828
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 828
gaaaaatagt atagttagtc aattcccaag gttgtttcaa tctttctttt attgcctgaa 60
aagtagctta acttaaaatc acttccttca aattgtttca ngtcaaatac ttctggatga 120
catttcagtt tctacctaaa atttaatatt tggtactaaa gaggatgata tataatttac 180
aaaataaaca tttgaagata g 201
<210> 829
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 829
acacgtgggg attcagagga ttatcaggat taaggggatt acagttcaag aggagatttt 60
gggtaggaaa acagccaaac tatatcagta ttctttatta ntagaagtca cttctggatt 120
ttaacatgaa cttgcctgtc cagcctttgt ttttggttct attctttttc acttttttct 180
ataagttcac agaaaccttt g 201
<210> 830
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 830
tcctctgctc tccctctacc cagtgaattc tactcatctt tcagtcattc ctccagatgt 60
ttttctaatc cacttacccc ctcctcatct atagctgagt nagatgcccc tcctatgctt 120
acttaagcct ctgtgccttt ctcatgtcac caacctaccc agttgtcttt ttatctattc 180
atatgtcctt attacttata t 201
<210> 831
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 831
cagctatgat ggcacaaaaa gttcataatt atactgatat aaacatgatt atgtttacat 60
gtctagaaat agagtgtacc attttattac ttataagggt nagtgacaga acacttaaag 120
atacgttttg aaagagcaaa tgcggtgtta gctgcatgac tcccattaaa gtcaatgaga 180
atcacgccgt taaaacactg t 201
<210> 832
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 832
tcgtaatttc atcaagaaat ataatatatc tctatttatt ctatcaagaa aatattttga 60
caattcaaat cagtgaacgc aaaactgcca aaatgaccaa ntagtttttt cctcatgctg 120
tgaaaaactg cattaaatct gtgatatgtc aaacaatgtt gtagctacct gttgttatcc 180
ctatgatgta tttgagataa a 201
<210> 833
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 833
tcctcctctg tctcctttcc ctccccacca tgccctgagg aaagcctcct ttttgcctga 60
atgcaattag atcctgtttc cgttttttag gtaaagacaa nagtggtaaa gggtgaggaa 120
ttttacaagt gctggccata gtagctgtct atctgtgctg ctgcttctgt atttggctga 180
gcgcatctat ctcttcctcc t 201
<210> 834
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 834
ggtagagtct gggttccttg tgcagcaatc gtagccccat gaactggtgt ataaatcaga 60
ctctgaactt aaattacttc aatcccaagt cttctgtgca ntattgttag ggccctctgg 120
ttagagctgt atgatgccgt tgacttcaag atcattaatg cacacccctt agattttcca 180
acctaaaatt aaagcagtgc t 201
<210> 835
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 835
taatcaggag cattttatct tttattctgt agcaatagtt tcagggggtc ttcctacatg 60
gattcacata gaagtggtca gttaagaaca gtatttcccc nggtgggttc cacagaacag 120
catgttatgt gaaagaaaac aggctgaggt caaatgaatc agggaaacaa caggcaaaac 180
attactaaac tttctgttta g 201
<210> 836
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 836
acccaaaatg aaagttggag aaaataataa ataaaataat ataaagtaaa taaaataaaa 60
tattggtaca taagtgcacc agtatgtatc taagttgaaa ntggacttct cccctgtagg 120
gaggggtgtg tgcgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttcccaaa 180
actctttgta tagtttgagg c 201
<210> 837
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 837
gcctgactat caaacagagg ctccagtgga agctgaagct tccaattgca ctatatacct 60
gatagcctaa tctgaaatga gaatctcggg ggaggtgtag ncattctcaa aaaggctgct 120
attttttttt taaacagaaa atataataaa actttactta tcctctctgc cttcagaagt 180
ttaacaaaag tgcattcttt c 201
<210> 838
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 838
tcagccaact tggaggatgg ccttccaccc tctcaatttt tactgagcat ccactacctg 60
ctgcacagtg tgctaggcca taaaagatgg tcgaaaccaa ngtctggtgt taaaaacaca 120
ggaataggag gatagtggtt ctaaaatagc cagatggttt ttgaggaagc atagcctatt 180
ggaaaggata tcggacagaa g 201
<210> 839
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 839
atgatattat gtcattgtca tccttgccaa gctcatgtat tttcttcatt ggtaagaagg 60
ttaaaaatgt aacattctat tggaagaagc acaaaaatga natgtgggga gcttatttag 120
tgattcatcc cccctcccac ttttttcttt gctggaatcc tatgacttct gaacaatgcc 180
attgctaagc aacagatcag a 201
<210> 840
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 840
taacattcta ttggaagaag cacaaaaatg agatgtgggg agcttattta gtgattcatc 60
ccccctccca cttttttctt tgctggaatc ctatgacttc ngaacaatgc cattgctaag 120
caacagatca gacacttcct tgcaagatgc aggtgaatca gaaggtataa tgtgagctta 180
gtcagaaccc tcatggatgc a 201
<210> 841
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 841
ttgggataaa gggtacaatt tacaaacata gaagtttgta attgtcccag attaccaagt 60
tttttaagac tttctgggta gacttcccca aactttccta ntttcataag ccaagccaca 120
taggattaga cccatcattt ttcagctata tgctagccat gattttctca agtggatgat 180
cagaagaacg gagaggtgag g 201
<210> 842
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 842
tcttctaagt taaaatccta gcactttggg aggccaaggt gggcagatca cttgaagtca 60
ggagttctaa gtgaaaatca acctggtatt gatctatgaa ngttttcaga aaactcagaa 120
ggccaccagg gattcatcca tgccagtgat gctgtgtata aagccaggta cacaacatgt 180
gtgagacccc acctctctct t 201
<210> 843
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 843
cttccctgat tcccccagtc ttcttatttc aaactcggta acactgcatg cctcatgggt 60
ttgttgtgca ataaatgtga aatcacatga cctctgggag nctgttacca ggccaagtcc 120
atagcaggca ctccacgaac aatgggttgc tctccctgac cacaaggagg atgtgattcc 180
atgtgttccc tgcttctccc c 201
<210> 844
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 844
gagcattata cagaaactat gaattttcaa aatctatgag tgcttacaag gtattgtggg 60
gatacgtgag tgagtgtcat gattatgcag ggcaggttat ncagcaacac ttcagggagg 120
atttaagcat tgaaataagc tttacagaag gagagaaact tgatttgaca ggaagaatta 180
ggatcagaaa accaccaaat g 201
<210> 845
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 845
aatttcctaa attggtctta ttagtaatag ctttaatgtg atgctgggaa tacacttcct 60
attaaaaacc atttgctata ttggctgttt tgacttgtgg nttatcttaa aatgagttga 120
cctcactgat atcttacaaa acacttcagt gttacagaat tagctctcaa ctctaacctg 180
agtacacaac tttagtttcc t 201
<210> 846
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 846
tgagtgtttt gcttctttga ggctaatctc tatcatttga ttgtaataaa tgaaaacagg 60
cataattgat ttttaaaaag acagtaacac tgttacactt ngctggtgga ctttcatgtg 120
cattctgcag gcagatggtg ttaaattaga aagaggattg ggcttggttg caactttggg 180
atggcctcgg ctcttctact t 201
<210> 847
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 847
cagaacagct ctcaaaaaaa aatcagaaca attatttgac tttactgctt tttcttctca 60
attccaatct gtgtgttact tttatttctt tctttccatt ntatgttggt aaatataaag 120
atgattgtgc aaaagtattt aaatatcgtc tgattatacc atttttcaga aagataaggt 180
tttcctcaca tccactgctt t 201
<210> 848
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 848
atgtgtaatt tgtatgagct ccgaccaaca ctatccatat acatccaata tgccctagta 60
acaaaacgca tatcaaacaa acaaaatccc aatttaagac nctgaaccag atttagtaaa 120
ggtcactatt tttttaaaaa agttaagtaa aatattaaca tatataattt ggtcatttaa 180
caaaagacct accaagtatt t 201
<210> 849
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 849
tgtggacctt gcagtgtaac actgctataa aaattcaaca aacaatgcga aattctaata 60
gtaagtcaga cattaatatt attttccttc ttgccacaac ngcaatatca accaaacatg 120
tccattctcc ttgttccatg tgttctcttg actttctcat tcttttgtta ttcaatcaac 180
aaatatatat tgagatctta c 201
<210> 850
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 850
tccacgggtc ctctgttgaa ttacaatgca cctgggttag aacaacacat gaagtcataa 60
ccaggaatag agagctcatg gagaaggaaa caaaagacaa ngcagttgtg atagaaaagt 120
aggaagggaa aactcagtct agagcacagg aattatttta tttagaaaga atagataagg 180
tcagtcaggc gtggtagctc a 201
<210> 851
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 851
gtgcatttag tgatcacagc aatgaggcct ctccccagaa tggccatcca taatccaacg 60
atagtctcag gctgtgagcc atctttagga agaccaaccc nactttaccc caattgcttt 120
ctgacccaaa gcccattaaa ctagactcct gatcaggtcc atttgtgctt tatgtctaat 180
tttaaaggag tgtgttctgg g 201
<210> 852
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 852
ctcccctgat tttttgtacc acaacttaat cctcatgcag atttactgtc tggattcatg 60
tgatttgttt gttccaaaaa tatatcaagc ataaccactt ngaatcctgt gagaaatttg 120
taagcatata attgagtatt tttgactaca tagagagata gaaaatgaaa aagagagagt 180
aagagaaaaa aggaatagtg a 201
<210> 853
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 853
cattactggg cttatatttc agtaataata ataattgtaa aagtaagctt ttaatatgca 60
cgattctggt tatttccggg agatttgatc ttgaaaggtg naacatatta aaattagagg 120
gctctaccct aagccccttc aatgtgttgc agaagtcctt taatgttgga ttagaagaga 180
tatccaatat tagtgaatat a 201
<210> 854
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 854
catgaaattg aaggagaata ttcacttgcc taaacagttg aaactcttta aggactccaa 60
gtattcaatt gccatgaggg agctagagaa aaaaaaaata natgtgtgtg tgtgtgtgtg 120
tgtgtgtgtg tgtgtataaa atgtgtgtat gtgtgtatac atgtatacac tattcttaga 180
attgtgggta catgtgtaaa c 201
<210> 855
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 855
catgccagag actgtgaata ctccctctac tccagtaatg agattcttat tgccaactgg 60
ccaatgaata gtttatctca aaaatcccat ttttagagac ngcttccctt tcctgacacc 120
atcggtcatt agcctagttc tgcagaagac tgagtttgaa gattattagg gaatgcttta 180
atgaaccata cctttaagag g 201
<210> 856
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 856
gtcaatgtat aatggtcaat ggtctgggct ccagttgaag gagagacaat taaaagcaaa 60
aataaaaaga agatggctga agacagttta aaaagtacca naatatgatg gcaacaagga 120
tactatatta agaatcaaga gatggggatt tgaataatta aaccataatt tattttctgt 180
gacaaaaaaa aaaaaaaatt g 201
<210> 857
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 857
gctttgctaa aaaagataac tagatatatt gcatattcct ttatctggga aattctaaag 60
ttgttaaaat ggattcttaa atgccttaaa cgtaagaaaa nagaatgtgt aaaaacttaa 120
ctcaaaaata tcaattttaa attatcaatt gaatacatga aaaataacgg aagagacact 180
tctgtgctta attctgctga a 201
<210> 858
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 858
ctaatgcgtt tgtatatgtg aagcacttgg cacaatatct agcgtaaagt taatgccaaa 60
taaacgttac gttgctatca cctttcttat tagcattaac ncaatatcca gattaatatt 120
aatatgaata ttagcaatat caattcaata tttatataac agaactctcc atgtattttc 180
taaaaccaga tactcaaata t 201
<210> 859
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 859
ttgggttctt tttgattcac cagcatcaag gattccagga cacagcagtc acctgagagc 60
tatggctgat aaatgtcttc attgcctcag agaattgttc nggggccgtg acgctctcca 120
gcattgcctg aattccaaac ggaactacat gcctttgtga ctttgaagat taatctctgt 180
cactcacagc tcgttggctt c 201
<210> 860
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 860
tatggaaagg aaaggaatca ctaggtctac aaatgagata tggaggaagt tgggggtaag 60
cctatgcaca ggtagagaca ctaaaataca aaaaagtaca nacctgccat tcacttttat 120
tttgatgttt caattgctct aaattttcta aatttatcat atgttcacaa tatggacatt 180
gggttagaat cttttttttt t 201
<210> 861
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 861
cagtgatgtg ggatttagaa agcccctttc ttttctgaaa gtaaaacaga cacagaggta 60
tccagaggag acaaaaaaga atcagagatc tctgacttta nggcctgtcc catatttttg 120
ttttctaatt ctaataacct ctcttcttgt tgaatgatgc ttggtaattc ctatcttcca 180
agatgctttt tagaagagct g 201
<210> 862
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 862
taaagctcat tttggcaaac acaagctgca cagcacagga aagggaagga tggttctaag 60
tccccttaag ggtatggaat gaggaatgga gactctggag ntgaaggaat ggcatggact 120
acagccaatg gaataatgcc atctttagaa tcttgacttt gggattgcag gtcatctaag 180
aaagcaacag tactgagtgt t 201
<210> 863
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 863
attgcctagg gctaccatta agaaaacaat ttaagtagct tatgccagag ggcctgaact 60
ctgtcttttc tctctctatt tgacttgcat aactcaaacc naatgggcac acatcatcat 120
tctttacttc taccaacaac tgattgacta atacttcatt cattcagtaa ctattaatat 180
ttgtcaaaga ccttccagac t 201
<210> 864
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 864
gctggagggt ggagggctga gagtgcctag cagcaatgca ggtaagacac tggcagcagc 60
tgagatggag aaaactcagg catgaggaaa cttcaggagg naaacctcaa gttacccagc 120
tcagtgagag gaaccatcat agactttgtt ttctaagcca gcagcctgag atttcccctt 180
gtggccaata caacacccac t 201
<210> 865
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 865
ctctctgcta cattttcttt tcatttcaag agtagagaaa attgcacata aagatgagat 60
ttttggttca aatccatttg tttctttcca gaaaattgca ntcttctctt ttaagaaaat 120
acatctatgt ctagcaaaac ataaggtcgg atttgcaatg cctctttgtg tctgaaatcc 180
ggactcttcc agtttggagc a 201
<210> 866
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 866
agttaatgat gtttattttc tgtggtttgt caacccttgg agctattgct actgcccagc 60
cttcttacca tgatctctaa tcttcttgtg ggtgtctttc naaaaaggga gggagggaga 120
aagagaggga ggtagaaaaa ggaagaaaga gagaaagaga ggaagaaacg aaagaatttc 180
ctgagagcag acagatttct g 201
<210> 867
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 867
ccaggaaagt tcagtggtta gcaccaagac cccagtccct tagaggaata ggctgttggt 60
agcaaagatt gaaccctagt gggtggaagc tgggaatcta nggacgaggt ggaagcatta 120
ttccagaaga aacaagacag ggttatgagt cctgaatcat aggatcagca ctgatcctag 180
gcagcttgaa ctgatgttaa g 201
<210> 868
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 868
gacaaatacc tataaattct ctgaaccctg ttcaggtgtt aacctcttct ttgacacctt 60
ctctgacaac tgaacccctc tggagttact tagcacacac ntgacatcca cgagtccacg 120
tttacctaga cagcaagatt gtgagctcct tgaggtcagg agactcagag gcttctccac 180
atatcccagg gcccagaacc t 201
<210> 869
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 869
caacagtgtt ggcatgatac ccaacttata ttagcttcaa attgtttctg aagcacatag 60
ctgagagtaa acattagatt cccattccat atttcattca ngggacaaag gagctaacca 120
cggacactta atggatcatg ctggcagaga tgtgagtgga aatgcaacaa aagtattgaa 180
tgtccattga acatagaaaa t 201
<210> 870
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 870
gagaaacact actgttgtca gcaagtgacc agtttgtgtg gtgagatgat aattaaataa 60
tatttctgtt tctctgttgg tatattgaag tatttgagaa ngtgtgacat gtgatatgtt 120
catggaaatt cagacaaatt acaattactt caatacaagt ttgataaagc catctgaaaa 180
acaaatctga agattaaatg a 201
<210> 871
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 871
cctaaaatga aatctgattt tatgcctgca atcctcttct acacgccgat ccctgaaagc 60
cagtgacttt tccccaagca tcttactgtt agctgtaata ncatcatttt aaggccacat 120
aattctagac aatactcaaa cacttataaa tttggggtta cactagcata ttaccaccca 180
gtctgggggc acagagggaa g 201
<210> 872
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 872
atttggtggg tgctgtgaat gataatagaa aacatggaga agttggatgt aagcaaaaga 60
cgtaatttta atgaacaaaa gacattgaat tataatgaaa ntggaaagac tggttaattt 120
cgtggaaaac taatgcaatc ttttaacata ttcttgcatt gcatatgtga agttcataaa 180
gatatgtgat gtttccaatt a 201
<210> 873
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 873
agctatttaa gctgaaggag ctgtttaaac ttctgttttc tgattttctt tatttctgat 60
atttgaactt catttcagtt aaatcttact aatctgcacc ntgcattatt cttatctgta 120
ggtttcaaac aaaacaataa aggggtaaaa gaaaaaaatg atggtcagta aaagattgtg 180
tattatattc aaatatcaac t 201
<210> 874
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 874
tatcacacaa agtgagtctc tttttattta ctttaactca atgagccacc ttaatctata 60
actcattctt tctctcagga atatcttctt atatgtatca ntgattattg atttagtctc 120
ctatagggac actaattatc cacatgttat tgactctcct ttccctgttc tccatgtcaa 180
ttatctttcc tgtcatcggt t 201
<210> 875
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 875
ttttctgctg ccatcctttg tgaaacggca aactaaatat gaaaaactgc tgataaggag 60
gaatagactt atgcccagag gataaactta acagagctca nctagcctgg ctggcattga 120
cccctgcctc tacattttta gtacatgtct cataaaagag aaactgcctg tgcttctagg 180
attcttttat ataagtgcca g 201
<210> 876
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 876
agatggatta agatgggcac cagcagccat gccaccctga gagtaattaa atgtaacaca 60
gcaagtataa aaattatcct ggttgcttca agtctctgag ntttgattca ggccttgaac 120
ttgccctgta ccaatgatta actaactaat catctggata ttgtgccaca agatgtcctt 180
tcagcctgat gcctagttca t 201
<210> 877
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 877
attaccagtt ctttccaata agaaaggttt tacttttttt tctttgcctt gtcaaaatta 60
tttcttcatg atgatgcact tgcaaattag aaaagttttt ncctccagtt tatactaaac 120
caaaattctt accatatttg tgaaggacaa ctttttaaaa ctttcaattt tgtcataatt 180
ttaaattcac agaacatgaa a 201
<210> 878
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 878
gaactttcac tctcactcaa ttattaatct tcttgcatcc cttaacatca caaacttctg 60
acacctacac tattccttac cttttatcta ttttgcacat nattgagtaa taaaacaaga 120
taaaaattca atggtttttt ggatttcaac ttttttaatt tttaaaattt tatttcaata 180
gatttttggg gaacaggtga t 201
<210> 879
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 879
acctgtcaca ttgttagcga cataacagca gaatatctca tggaattagt cattgtgagt 60
cctctgccat atagctcagt ggagtgcaaa cctagtgtat ngtgtcctta ggctgaatca 120
gaaaaggttc cattgtacat gtaaataaat gtctagactt tcttgacgat tagttctgtt 180
cttagtactc aaattttctt t 201
<210> 880
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 880
atgatggagt cttactttaa aatgaagttt ccactgaaag aaattatcaa tactattctg 60
aattatcctt gaaagaagtt aatcccaggc aggaaaaaac naaaagaagt aactgtagga 120
acacatattt tccttcttct ctattgcctg aagaattaag cctggaatct gtaaaatgaa 180
taaactttaa atggttctgg g 201
<210> 881
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 881
aacgatgtgc gtttctccac cactcaggct ttgacagctg gtatctactt cactctagca 60
agctgaggtc tctcctcctg attaggtcag ctcccttgat natcataatt cttagtgtca 120
caacaacaca gaaacaacaa taaagcaatg ataacaacaa agtattctga gcattgacat 180
acctttcatc tctgcaagtt g 201
<210> 882
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 882
aacttgatag gtttcaattt aatgtgctat caaatgtcac caacgaattt cccatctgaa 60
atatgtaatg taaacatgta ttcagccatg tttctctaag ntttgttctt ctcattctaa 120
tatgagaaat tatttaactt gtgttatctc tgccttttag aaatatgtgc aaattttgtg 180
gcaatatatc tgatgatata a 201
<210> 883
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 883
gcacatcttt ttgacaattt ggaggctaaa aagcaaatcg ccctgaaatt aaaatatata 60
taacccccaa ataatgaact atctcttttt gagtaactac nttgatcaaa gaaccaagta 120
gataatatcg tataatgttt ctaatcaagc caaagtcacc tgtatttctc tcatttccca 180
aaaatgtcag ctgttatcca c 201
<210> 884
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 884
gaatttacgt ttctaaagtt tctaggtgat gatgatggtc tagtctacag tttgaaaacc 60
actacttaga tcattcatac aagctaaatt aggatacttt ncagtaagga gtaattagca 120
aggtgtggag aaagaaatgg gcacatagct ccaaaagcag tagacatttg cctagaaagc 180
acattgccta aggactatca a 201
<210> 885
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 885
atcaaaatat agaacatttc catcatccca aaaaggtcta ttataccact catagtcaaa 60
acacccaata tttctcatcc caaacaatga ctgatctgct ntgtgtaaat ctatatgtac 120
atagtatgta ctctgttgtg tatgatttct gttacttagt ataatgtctg tggacctggc 180
atgatggctc acttctgtaa t 201
<210> 886
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 886
ataagatgcc agaggttttt tcctctaaca tgcttcctcc ttgaaaccct ttattcaaga 60
tatcagctat caaatgacag cattaatttc attttgaaag nttgccttta ttgagtgaat 120
agcaaatttc aagctctggg tcatgacttc caaatgctat caagaaagag ggcaaaaaaa 180
attgtgaagt gaaagcaaaa t 201
<210> 887
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 887
tcgatcagag tcttcagctc tccactcagg agggaagacc aaagtgagac tgtttttaga 60
atttcctggg aaggcttgca gaggcaggta tcaaatggca ntcaaccact ggccactggg 120
ggacaagagc acagaaaacc tgcagaaact gcatcatctt aaacatgtga aatcagatat 180
tagttggggt cctgtaactt t 201
<210> 888
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 888
cgtacactca tacaagtgac aacaagttga ctagaattgc tggaaagttt tggttggtct 60
tgatgcattg tatagctttc tgcccttata ctgagttccc nttttcttct ccctgcccac 120
ctttgcccac catagcctaa ctcctaaatt gctttaggag ctacaaattc cttcttttgt 180
tttacagttt tctcctttcc t 201
<210> 889
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 889
gggtattgtc ctaccttctt aaattactaa taattctgct actgaagatt tgacttttct 60
tccacatttt tctcacatga caatgtttct gaaaccctat ngattttctc cttcttaaaa 120
tgaaaataat aaaatgttgg atatggaagt attttgaaaa tatttttaat tttataagga 180
aaggaagcaa ggcatgagtt g 201
<210> 890
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 890
ttcattgatc taagatcaaa gaatagagaa aataaagaac aaattaggga atgtggaaag 60
aggttttagt gtgggcaaat agttgaggga ggggactcca natgagtatt cacaagctgg 120
ataaggacag ctggcttgat ttcttgattt gacactcatc caatacaatt ccccccgctt 180
tcaatctgcc tttctctctc a 201
<210> 891
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 891
taaaaggcta aaaatcataa gataaaactg cccctcaact tctaacagga ctcaggcctt 60
ggggctcctc atcagtttcc ctgcttttcc agggaccaac ntcgcttttg tacatccaaa 120
gcaaacaaaa atgtaaatgt tttaatccca tttgaacaag aaaatagctc tctatatata 180
gaaaagattt atcatatgaa t 201
<210> 892
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 892
cttcctcttc ctccccttcc ttcctttcct cttttaattc ctcctcccct tccttttctt 60
cctttttctt cttctttctc ttttcatcta attgccacag nttagatgaa actttgcccc 120
cttttggaaa ccttccttat gttcccaaaa tggttaggtg aacctgcctt tcttctttca 180
tatcacattg accatagggc t 201
<210> 893
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 893
cccttttcat caggggtaca tgctaataag tgcaggcaaa ctgtctaaat atttgcaaca 60
aaccctggga gcaactacat ttttagcaag tatgaattcc ncaacatcca gtgaaaggat 120
gctgtctcaa tgaactatac tcaaaaagct aagagacttt tcattttatt ttaaacacaa 180
gactagtaat tttactttat t 201
<210> 894
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 894
atcattcaca tcttacagat ggagaaactg aggctcaggg agtttttgtg gcctgttcaa 60
ggtcctgtag gtactaacta tcttagcact gcttctcgat nccacgggag gaatttcgag 120
ctggtcctgg agtctgccca gcagcatgat ctcccttggc ctggaaacat tttggggcct 180
gcaggacctc accaagcaat c 201
<210> 895
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 895
tgagataatt atctaggatg gcaatccaga tcatgcaata ctttcgatta gaatatgcag 60
atgatatgca aataattgag gtcaaaattt tatttaacac ngggcaaaat agaatgaaaa 120
tcaatccatt gaattttgtt cacacagagg tgggacattt attttcatga cctaaaatgt 180
accaatactt tatgttacat a 201
<210> 896
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 896
tttttaggta taacacatgt taaacgagct tttggtatca ggtgaggaat ctaccttaac 60
tgctaacatg caaagataag atccacacta aatacaagtc natagtgtgg accttataaa 120
tggggcgccc ctttgtggaa atgagaaagt tattttggct ttattccctc attttctcaa 180
aaagttaaat caagacccct g 201
<210> 897
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 897
aacaaacaaa aacaagaagt actgcattga aggcaggggc ccaagttacc taggtctaag 60
ggtggtaatg ttataatcac acaaaggtgc agtatgcaat ngaagcttta aacctaggta 120
tcgcattcac tgaaaacgtt ttcagctaaa gtgtctcctt caattagtgc tgttcaaaat 180
aaaataattg ggaaagtaca t 201
<210> 898
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 898
tcatgaaatc caaagccatc aaaaatagac tgtagattca tgccaggatt agatttgttt 60
atgtaaatcc aaaatattta gtgtcaagtg gtactaaata ngcaggttca ttgagaaaag 120
tgtgacaaat acttggattt tagtaatttc atttgtatgt atgtgtatat gtgttttagt 180
tttaaaatat gattctgccc a 201
<210> 899
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 899
aggctggcat gattcccagc acaacccacc tgtaccttgt ttggcaacag agattcaaga 60
ttttacgtgt ccactgggcc aatgcatggc atcccttcac ngttcttctg gtattcatca 120
ctagaggttt tcctttatta ataaaagcta acctataccc ttgctaagca aagtgtggtc 180
tagggaccag cagcaagaca t 201
<210> 900
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 900
acttctggat cttaggaagg aagtctgcat cgatagcaag actttgtctt ttgttcttta 60
aaaattataa taccccactg tcatctacca aatgaagata nccattattt atttaaattt 120
gcaatgcttt ctctccccag ttgctttgga gtagaagcat cttactgtcc ttggttcatt 180
gcttttccca ttttgttttt c 201
<210> 901
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 901
tcatgatctg tagtccatag aagggagcaa gaaactatat ggattttctg ccaaagacac 60
aattgttcta tttactaata aaaggggaaa catattttta ncctgcagtc cttatgtagt 120
catgatacca gataatcagc tccagagata acttcaaaaa agagcagctg gacaaatttc 180
aggagatatt ttatctgtac c 201
<210> 902
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 902
tgtatgtttc aaacattata taccatttat ttataatatt cacgtagata cgtatatgtc 60
taatgtaaat gcatgtaatc tatgttagta atatttccgc ntcttaggat catattgcat 120
cattactttt aaaaatggtt gtatgattta cactcccttt gttggtctat aaatatatcc 180
atttctctct agaacagtgg t 201
<210> 903
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 903
gatgtaacta ttttatgata ttatttctaa aatgttgagt taggctttga aatttggcca 60
agagagggca aaaaagaaat tgaaaaatta agagtggaaa naacttctga tggcattaat 120
acttaataaa gatttcattt tgatcaatag tttaggccat tggaaaataa ctgataactt 180
tttattccct ccccttagta a 201
<210> 904
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 904
ttgcaggaga tagaagttac agctgccaat cctagggaaa aagtaataca tcctatccag 60
tatgctggga catcctactg tagcacagca agctttggct ntggaaactt ctcctgtcca 120
tatggtgttt ccatgtttct acttgcttct ctcgacttag ttttcgtgat ttatgacaaa 180
ggtgacaatt acagcaatga t 201
<210> 905
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 905
atgttactta ccttcctgca gtggaaaagc tctcattagg acaagcacag gtttttatgg 60
atgtgttttt atcactaact ggctgtgagt ctcctcaaag ncaatgcttc tctgcaggcc 120
cttgctaccc agcttgttca cctttaagct ggggtgaggg agggtgggta taaggacaag 180
atgatataaa agaaatataa a 201
<210> 906
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 906
ctggcaaaag ttaggctaca ttggaaagta agtttgaaag attcgattca ggagtgtact 60
ttgtccttag aatacatttc aaagctataa ggtttgccac ngtccatttc aaagatttac 120
ttaaaccctt caaactcctg tcaatataat aacaaagaat gaatgaataa agagttaaac 180
aagtgagcta aaatcctttt g 201
<210> 907
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 907
tgaaagaatg ctgaatattt gtgaaagtaa ttaaaagtat gtgttatttc tctgaacaga 60
tcaccagcac tgatgaaact ggtgtattat aaaatttctg ntgtattaca tagctaatga 120
ataaggaggg aatagcttta tggcagcaat gttcaagctg attatcttag ggtcagtgct 180
tcagtggatt tcaagagata t 201
<210> 908
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 908
cctgcacgtt gtgcacgtgt accctaaaac ttaaagtatt atttaaaaaa aaaaacagaa 60
aacaaatatg taaaatgcca aaaaaaaaaa aaaaaaaaaa naaaacaaaa gtgactattg 120
ggccattggg cgcctaagaa atcctcttcg gtgtctgtcc ttgtccctta tccctactgc 180
agctgagtgc ttcctgcttt g 201
<210> 909
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 909
attaaaatta aagcagccta taagtgtaga acagtgggga ttaggaatat tgaggtttca 60
ttggtcaagt ttttcagtgt cataaggaaa gctgactaca ntctctaaga gggagagaaa 120
ctgagtcaaa tagattgtca agtggaattt gtagacagca cagttctggg caatcccatg 180
aaaaagcagg tcattcacct a 201
<210> 910
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 910
cttcatttaa taaaatctac aaagactctt ttcctcagaa ggtaaaattt acaggattca 60
gtcattagaa cctgctatat tttgatagct attattcagc nttcaaaagt atagaactat 120
ccctgagaaa caatggttca gtcaattata cttccctaac cgctttacct ctggatgtaa 180
taatgtgatg ttattgtcaa t 201
<210> 911
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 911
agcaataccc cagcactgct accagcttgg tcaattttag cgtaaagata ttccacaggc 60
aggggggaaa tgctgctgga gaaagcagga gcccacaaga nggatagttc atgtgtgtga 120
ataaataaag cactgctgga gtttttgaca ttttggagag gaattcatta tggttcatag 180
gtacaaatgt aatgaccttc a 201
<210> 912
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 912
gcctggagcc aagtcacagg ctcctttacc accacccacc catccacccc ctcaggcaca 60
cagacttact atgaataatc atttgccagc ttctagaatt nttttttttt cctctggatc 120
atgactttgc attttagaag taagaaatta tggaaattca agttatagag tttatgaata 180
taaaataaca agtaaaacaa a 201
<210> 913
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 913
ttggcatgaa attgaagaga agtcctcatc atctctcttt tttactcttg accacaccat 60
tcagattgta tttgaaagag cctcttttct tcaaatgcca ntgctttaat ttgcaatcct 120
gagattaatt gctttcatac tgaattttct tcatctcatc ttgtttagtg attggattat 180
tgatctatat aaactttgtc t 201
<210> 914
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 914
atttcaggga ctatgagtca gtgcttagaa ctgacttgtg atttcatcaa ctttctttag 60
gctggaaaat gcacaggctt gtgtctgtct ctgttgccca ngaaagcatt cctagtgttt 120
gatgcaggca tcaagactgt gtcttacctg gatccataat ccttcagctc agttgtttct 180
aacactcccg ggaatctttc a 201
<210> 915
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 915
gaaaacaaat tccacagttc tttccgtgag tttgcaaaag tctacacatg gagagtgagt 60
aatgagtttt ctactatctg ttagcaatgg tgagcctggg nactgagtga cagacagtct 120
atctcacttt gaaatcaact ttatgcgttt aaagtttcat gtttagagtt aatctgtgga 180
caaacatcta tgagaacttt t 201
<210> 916
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 916
ctcttaagga agtcaacaca aaataagcct agttgagaga taaagagaga ttctgatgat 60
attttggagg caactgtact agccacatga gaaaatgttt nacttctgga tgtttcaatt 120
agtcatcccc tcgatttttt gtgctttcac acacacacac acacacacac acacacacac 180
acacacacgt aagaggccca g 201
<210> 917
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 917
taagaaccat gagagcttag gatgggaagg ggctcctcct ctctaccttt cctcccagcg 60
agtgctcagg acatcttccc gctcaccccg tttcttaaat ntcctccctg actttttcct 120
ccagtccctg tctctaaact ttccaactat ttatttcctc tgatgttgtc tgaagctcca 180
ggataattgt tgcaggagaa g 201
<210> 918
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 918
gaatttccca cagcctggat ttcacccagt gcagttccat atgccctctg taattcctgc 60
aaatgactct ttttaatggt cacaccgtga tttgtaacca ntgccttaca attgcccagc 120
ttacagttct gaatcgctag aatagttacc actaagatga acatccttgt gtatattttt 180
tgtatgtttg tggacgcctt g 201
<210> 919
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 919
accttataag taagaactat ttacaaaatg aagcaattcc acactttaca aaaagatttg 60
ccaaagcctt ccttgaaatg ctgcactctc taggggccta naaaaatgat tttgatttat 120
aaacacattt cttttatgct ctgtgaaagt tgattatatg aattgggcca ttctagtcat 180
acccaactaa atcagagtca a 201
<210> 920
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 920
atccccatga ggtaggcagg gtgcttccag gtgaggcaag tgaggctcag tgagaggaag 60
agactgttct ctccagcgca tcactggcag tcagataaga ncccaggact ccaaggcaca 120
caaaacaggt aggtgcttaa tgctggaaag cttggtgacc ccttggccac ttgtgaggtc 180
tatttttgaa gctgctgaag g 201
<210> 921
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 921
aagactcagt gaggtaaccg actgtcccag agtcccacag ccagctggtg gcagaactgt 60
ctcaaaccca agtgcctcag agcccagaca ccctggggca nctgcctccc cacccctctc 120
cctcccactc actcctgccc tctgctctcc agtcatagta tccacctctc agccaagaag 180
gtgtcaaggg ctcctctgcc a 201
<210> 922
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 922
acatcagcag caagaagcct aatggcagtg tctaatgctt ggcatcagca gagttggtca 60
tgagtgactg catccacaac cagttggaca gccatgtgac ncaactgaac tagctttgca 120
gcacaatttt gggtgttgcc tctgaatgca tactctctag gccctcctag aggctcttca 180
tgctttctaa tacctcttct a 201
<210> 923
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 923
gatcaaaccc aaatgccttt cctttgagat tctcttcctt cctctgctga aaaagcatta 60
ctggttccat ctctggcttt gggatgggag gacagtgtgg nctattattt atagagggtc 120
tactatgagc caggctctgt actagatgct tgacatatgc catctcgtgc aagctgcccc 180
aaaatttatg aggcaggcat g 201
<210> 924
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 924
ggggtaatca atggaaatta attttacaat gcatactttt tactgtttta tggaaaataa 60
atgctattga tagtcttgtt atgctgcctg tattgaatta ncttagcaaa tacaaagtcg 120
tgtttacatg tgcttttata acttgcctta agtatattct gtcagcaata aacaacttgg 180
gtgcacattc taaaatgaat a 201
<210> 925
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 925
caaacatcaa tggagtggta agaatgaaag tccttttgga atgtgaagaa gatagagtgg 60
gaagtaaaga agtaaagact gaaaggatac actgttctta ngaattctga tggacttttc 120
cttttagaaa tatgaacaaa aaagaataag tccaaattaa atattcttta gaatattata 180
caataaaagt aacattatta a 201
<210> 926
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 926
tctaccacgt tcacggtctt cagtttgctt cgaaattatg tttccacatg cttttgtaca 60
agctgttgtt aactccctta aatacctttt tctaatccca ncttgtagga aagttcaatt 120
ccttcttcaa agcacaagca acaacttcaa aagcgaagcc tcccttgact tcttctccca 180
cttcaaagtg gcattaatga c 201
<210> 927
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 927
atcaatttag taatggtgtt tgtaaaataa gacaataacc cgaatcttta tatagttctt 60
gtaacttttc ataacatttt cacataggat gtcttggcca nccacagcaa caataacatg 120
aggctgatat tctccccatt tcatggatga taaaactaag ccaatggtta actggattgt 180
tttgtaaata tttggccacc c 201
<210> 928
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 928
gtgaaaactc aaatgcagac cccctgtaga tctgtgagag gtctgcgtag agctctctcc 60
atcctgtact ctgtcttgag aactctagtt tccttaggcc nctcccaggc tctgggctta 120
tttgtttaac tcagggaatt tgatggcctc tgcttggctt ccgctttcat gtgatgcttc 180
tgggaaactc tttgaggcag t 201
<210> 929
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 929
gacatttttg ttgtccttaa atcaaattct gaattaagtt attttgacct ccactaactt 60
tgggatgttt cagagattcc ctagaatatc tcaaaataat ntgttcactc tccttacaaa 120
aaaagatatg ttaaattaat taggcttatt tggtatttta aattaaatga aaaacattgt 180
gtcactcaga taataagtga c 201
<210> 930
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 930
tgttggagga ccatgctgag tgaagtataa gaaatcatga gatggatgcc gaaagcattc 60
taaatcctag ataataatga agccaacata tcagcactta nttgcttatg tggaaaaaaa 120
aaaaacaaaa cttctcttta ttgaagctac tgctgttttg gtggagaacc tcattgttgg 180
gtgtttgtaa ggcttgtgtg a 201
<210> 931
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 931
attttactta tagtatgctg tttgtgtaaa ttctgtacta aaactataga tgagaatact 60
aacgtgtttg tcatgaaagt cttacaatcc cagcccaact ngcatgagta taatcagaga 120
gctagctgca aagaatttct gctcttctca ccttgggatc aacttctatt tccactctgc 180
cccctttcag caggaagaaa c 201
<210> 932
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 932
atttataaaa gttttggggg ccatggtagt gcagtagagt ttttaaggtt gtttgagcag 60
aaacaagaaa acagcataat gcaaaaagac agattggtta ntatcagctt acttcaggtc 120
actctcttta taaaggttat aacagggggg actttcttat gatactagct caggtttact 180
gggccctgtt tggttgctgt g 201
<210> 933
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 933
attggagaaa gaaaagcttc tcatataaat taatttatag ccttgatgcg cacacattaa 60
actttgagca tgtgaatgta gaaagactaa gatccattat ngatgtccct taggtaggca 120
gcgggtacca cggcctagag cagaactagt aaaaataagt ggaaaaaagg aagagacaca 180
agagggtgtg tgtgtcagtt t 201
<210> 934
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 934
ctttctgcga gacagaccaa tagtgattca tgtaatacac ttgtgctgaa ctattttggt 60
gaaccaaggt agtgacaaag cttttcatta tttgaaggag naagggcagc aagcaggaga 120
gcaataaaca ggttcctatc actattatta cccctattat aagagtttta aatcctccta 180
atgctgggaa ccattttcca a 201
<210> 935
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 935
ttgactcatt ttgaacttga ataagaaaat tgctcgtatt tgctttttgt ctaacatcat 60
ttccatagtc taaaataaaa aaaaaataaa cagctagtaa ngtcattagc aaaaaaaaaa 120
aaaacccata aagcaagaaa tgtacgttaa aatgatgtat aacataacca catttattta 180
aaaatgtatt ccaacatcaa a 201
<210> 936
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 936
ctgtgggttt attctgaaca tatccttctg ctacttgttt gtttacttta atggcattat 60
attcctgata attactcaga ttgaggcaca gagatatcat ntattaattt tactgaaata 120
taatattact tatacatata tatgtacaat ttattatatg taataacttt attccagtta 180
attactatat tattcgtaaa t 201
<210> 937
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 937
ttaacatgga gtgcagatat ttttatatgg tggtaatttg aattcctttg ggtgtaaacc 60
tatgcaggga ttgctggatc atacggtagt tttattttta ntttgtttag aaacttccat 120
ataattttct gccatagctg caccaatcta ccttctcagc aacagtgtac aagtgtttcc 180
tttcctccac actcttgtca a 201
<210> 938
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 938
caaggttgga ggtatggaaa tttcagagat taggaaaggg atatatagaa gacaaaaacc 60
acaaaagact gtgttttttt aaaaaaagat aattaggaga nagcattgtc atagaatgca 120
aataaagaaa gtatatcaag aaggaggaat tgatcaaaag tgccaaatgc ttcatagaga 180
aattgaatta cacaaagata a 201
<210> 939
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 939
gaagtttttc tttggttgct aatgagatga ctaatgtctg gtagcaccta ggtaacctta 60
ggatgggggc tggtcactgg aaagtccaag gcatgattag naggttgcaa ctttcagctc 120
cacaccccaa acttagagga gggggaaggg tggaaggtta agttgatcac aaatggccaa 180
tggtttaatc aaccatgcct a 201
<210> 940
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 940
ttataaaaat caattaccca tttttaattg agttgtcttg ttattattga gttgtgagaa 60
ctcattatgt tttctgtaca tcagtctctt atcagatatg ngagttgcaa atactttttc 120
ccattttgtc aattgtcttt ccactttttt gatggcatca tttgccgaac aaaagttttc 180
aattttgatg aagttcaatc t 201
<210> 941
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 941
tgttcccttt gaggtcagaa acaaagcaaa gatatttgtt tttaccactt ctattaacta 60
ttgtcctcca gtgcaataag agaaggaaaa gaaataaaag ncataaacat tggaaggaaa 120
aaagtcaaac tgttttatta ataatcatat tgttttgtaa aataaaaaat catgagaatc 180
tacatttttt tttcttttga g 201
<210> 942
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 942
gaaagacata agcaaattaa gttttaaaat aatcatacta gctcctatga agttggccac 60
tgtggcctgg agaggaagat ggaatagata ataaaagaga naattaatag tggtttgact 120
tggatggttg tagtctaagg gatgagaagt agtcagattc tagatgtact ctagagatat 180
ctagagccaa tagcatttga t 201
<210> 943
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 943
gctgtttttc agatttcttc tttgtctctt gctttcaaca ttttgaatgt gatgtgcctg 60
ggtgtggatc tctatacatt tatctaattt gcagtttgtc ntactttttg gatgtgtaaa 120
tctgatgaaa aacatcagat ttgggaagct ttcaatcact atttatttgc atatactttc 180
ccctttgtct cttttctcta t 201
<210> 944
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 944
cctggtacct cccagatttc atgtcctcac atttcaaaac acaatcatgc cttcccaaca 60
gttccccaac gacttaattt attccaacat taactcaaaa nttcaatgcc aaagtatcat 120
ctgagcaagc aagtctcttc tgcctataag tctgtgaaat caaaatctag ttacttccta 180
gatagaatgg gggtacaggc a 201
<210> 945
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 945
ttatcaaaca taggaaaccc ttattaagtt tgtatatgat ctgtaggatt tgggagaatt 60
ttccacaaac caccatcagg cttcctacat ttctaatctg ncttctcctc cactacctca 120
tatacccagt gtccaatatc ataggacaca ctaacgttat aactcctgct ccgtggtctt 180
tctgtcatgc tgctgcgtaa c 201
<210> 946
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 946
tgtggcattg cagattattc cattaagaaa atgaatctat ctctctgccc cttgattctg 60
agttggccat ttgatttgtt ttgtccaaaa ggacattaga naatgtgatg caagaagaga 120
tttataatgt gtgtgtgtac catcatacta ggacaccttt gctgcttttg ggattcctga 180
agctgccaca tgaaaaccaa a 201
<210> 947
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 947
cagctacata cctcaagatt ctgaaaaagg acaactacag aaatactagt aacccaatgt 60
aaaatgtggg agcaattata actgtaatat gtcgatttca naatgcacat gtcaagtaaa 120
tacaacgaga cattgggttg tagcagagaa agaagtttaa ttgtaggact actaaatgag 180
gagctggaag gaaatctcaa c 201
<210> 948
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 948
ggtctcttct tttttttctt ttttcttgtt tttgcataaa ccccctaccc ttccactctg 60
taagtcagag cagtaagagg ccctccacag atagagaacc ngatattgga ctttctagtc 120
tctgtaattg tgagccaaat agacttattt tcctcataaa ttacacagtc tcaggtattc 180
tgttatagca acagaaaaca g 201
<210> 949
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 949
aagatttatt atctactgtt ttgttaacat ttcaaatcag catatataga gagaaaacat 60
tctgagcaat tttatttact aattttcacc cagtccctga ngaaatgctt ggtagatagt 120
aaaaactgaa aaaaaaaaaa aaagattaat caagagtttt ttttaatact acagaattgt 180
ggaaagaaag cattttgatc a 201
<210> 950
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 950
gttcagagga ggaggagagc taaggtcacc tggtctgtat tttggccgag tctctcacat 60
ttctgcatga agtctccctc tgagctaagc caaactgtgc nacttctcat tttctctata 120
ttctcttccc attcctactt ctgtgccatt gctgaaactc ttcccttggc ctggccttca 180
cttctccaca tctgcagtcc t 201
<210> 951
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 951
gtttgatgaa atccaaaata tgactttttt atgcttcaga atttttgtgc cttgtctaaa 60
aaaaattgcc tacatcaagg ttacaaatat tttcctttac nctttctttc ctgttttata 120
attttggtat ttatatttaa gtctacaatc tattttgaat tagttttttt tttttttttt 180
tttgagatgg agtcttgctc t 201
<210> 952
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 952
ttccaaagta aaaggaataa tataaaacat attaatacac tgttcttttt cacatatact 60
taagtgtgat ttgcccaaga ttcagccaaa cacattattt nccaacaaga aaatgaaggt 120
tctgtcgagg ctcagaaaat ggtaccctaa agtatgtcac tttgtcatgc tgagcactta 180
gaattaaagg aaattggaag g 201
<210> 953
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 953
tataatggaa ctgacttttg taggttttta agagccaatt atatacaccc ctttccaatc 60
ctgcattcag tgatgtcaca ttggtagctt aaaatcagcc ntggttggac tatttacacc 120
acggaaattg gcaaacactg cactccatgg agggatggtt gttaaatatt tactatacac 180
actactgagt ctaaatgaca c 201
<210> 954
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 954
tttccatgga agaaagcaag tttctaagat gttaaatgac ttgttgaagt catgcaacta 60
gaactaggct ggaccagcat ccttcatctg acatttagca natgcattaa atatgctgct 120
atgccatgtg ctctttaata caatggagat atagcagtca atatgacata taaagcacta 180
tctctcttgg agcttacatt c 201
<210> 955
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 955
caggaaaagt tcaaagcaga ttttctgaaa caataaccac aaaaatccca aactcagtga 60
tttttaaact caaataatat ggtccatgaa gatgagaatg ntcactactg agagttaaat 120
tagtagtctg aaaaaataca caggggtgga aatattgagg gaaaaagtaa gagaacttga 180
aatttggtct ggagacctaa a 201
<210> 956
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 956
aacccagtga aacccagtga aaccccattc tacagatgaa gtcaaatagc ttaagtaaat 60
tgcctgaagt tacacagtga ataagtggca aaaataggct ncagggcctg ggttaataat 120
tatgctaata attcaaattg gtgttattta taagatttat gactttctag ccctccaaca 180
atagaaaatg agaacattaa c 201
<210> 957
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 957
agccaactgt ggcaacagga gcagaggctc ctctctgagc cttacctttc tcatctatcc 60
tacttgtact tctcatagtt gttgtgaaga gaaaatgaaa ngaagtagat gctcacatga 120
aggtattttt tacatgtttc tgattttctg tttatttctg cccccagact ctgcaatgat 180
acatgagaga gcagagacca t 201
<210> 958
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 958
atacagatgg agctgcctga ggaatccgag ctatttgagt ctttccagcc cacgcattca 60
aataggagtg aaaaagcctt tgaaatgaga gttcatgaga nttcctcaac ctgaatggtc 120
cttatgagcc atgctgtgtt cctaaccctt agaaagtctg agagataata aatgattgtt 180
ttaaggtatt aacacagaaa a 201
<210> 959
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 959
gcttgttagg atcaagggat gtctattcat ttgttcaaat ctaacattgt gttgatcagg 60
agtactttaa atttttcctt ataaacactt tggacatttc ntattaactt tatccttaag 120
tatttgatta tctttgttat tataaatggg gttttctcta ccattatgtc caaaaactag 180
ttattgttta ttacaaaaat g 201
<210> 960
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 960
tcactgcagc cttgacctcc tgagttcaag ctatccttcc acctcagctt cctgaatagc 60
tggagctaca ggtgtgggcc actatgcctg gcttgttttg naacttaaag atgaggttct 120
cactgcatta cctaggcagg tgttgaactc ctggcttcag gtcatcttcc cactagggcc 180
tcccaaagtg ttgagattat a 201
<210> 961
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 961
gctgctcata gcttttactt attgggcact tcttttatgt tgttactttt ctgctctagt 60
actctaccca tgccttgata cagaatgaga ccaagagctc nttattttgc ccgttagttg 120
atgcgatttc ttcatactgt cgatggtctt tacaatttgg catgtttttg cagtggctgg 180
taccgttgtt cctttccatg t 201
<210> 962
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 962
cactgtgggc ttcactgtgg gagggtctgc ctgaacaata gctgtatctg taagtctttt 60
cttttggtct ggtcagattc tgttcttcta tttggatggc nagtctgggc cttaaagctg 120
aatgtgtgaa gaaagctgtg ggtttttaac attgagaagg gttccccagg tctcagctga 180
attttttttt tttttttttt t 201
<210> 963
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 963
gcctctcaaa gtgctgggat tacaggcgtg agccaccgca cctggcctga gagaggaaga 60
tcttatagag aaaagtgctg gtgtgctact gcagatcccc nagccatggg gaaaggaagg 120
agtattcccc ctaaaatcta agcaaatgag agagcagggc ttcaagagga cctcttgtgg 180
agttggacaa atgtcccctg g 201
<210> 964
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 964
ataggcatat tgttttagtc tattcatgct gccataacaa aacatcttag actgggtaat 60
ttataaaaag cataaactta ttgctgacaa ctatgcaaac ngggaaatca gggttatgga 120
gactagggaa gtctaagctg ggggattagc aggtttggtg tctggtgaga gcccagacac 180
tgcttccacg gtggcgcctt c 201
<210> 965
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 965
aaattctagt tttctatatt actgtagggt gactgtagtt gccattagtt ccttatatat 60
tttcaaatag ctaaagaaaa gactttgaat gaccccaacg ntaagaaata ataaactttt 120
gtggtgagag atatcttagt taccttaact tgatcattac acattgtata catgaattga 180
aatattcttc tgtacctcat a 201
<210> 966
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 966
atggcagcac tgttatgaga tacgggaagg gggaattgga aatatcctgt tgtaatgtaa 60
ctacagtatc tatgaggtgg tacagtgtta tttgaaagag ngcttggatt acttgtaagt 120
gtacattgca aacttaaagg aaaccactaa aatagtagaa gtggtataat tgatattgat 180
aattgatatt ttgaagctga t 201
<210> 967
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 967
tccaagaatt tttgtttcaa cagtgtgttg gaagctttcc actgtaccct cagattccca 60
caaaagtact cttgtcaata gatagttgcc agaatctatg nttctgctgg ggaatgatgg 120
tagagagtgc ttactctgac atcttgctaa taacatttcc ttattttagc attttgaagt 180
cggtaatcct gcactaggat t 201
<210> 968
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 968
ctctgcccaa tcattctttc ttcccttccc ttacccagga attgacctca agagcactcc 60
ctaataaaca tcctgtaccc catctcagaa tctgcttcct nggaaacccg atctgcagta 120
gctgaagttt cttctccaaa caggagcaga tggttgctcc aaggtgatca ttactatctt 180
aatggttgat cagtacaaca c 201
<210> 969
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 969
aaaaaaaagc tgagactcaa gggagttggc cttgacattg accaaggtca ctattccaat 60
aaattgagaa actgggacac agcctgaaac atcaatctaa nccaaactca atactttctt 120
cttattctgt gctgcttctc cctaccccac cccagccaat aaagacattt ggttaatata 180
tgcttaacag ttatctttca a 201
<210> 970
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 970
agtgtggatc tggaggaaga aaaccacaga ggcgatgtgc ccttctcatc acatcacatc 60
aaaggatatt acatgatgtc aacatgttct attttggata ngatagtgtc tgcaagtttt 120
tccactgtaa atttcttata tttccgtttc taaactctat tctttagaat tgctgcaatt 180
tttatttcac aatcttcatt a 201
<210> 971
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 971
agtttgatag atgcttgcat ttactaaagc atgccaacag ttgctttgtg tatctcatta 60
ccaactgtgt gactttggga aagtcagtat tcttagtgtc ntcatctttg agtctgcaaa 120
ttagggaggt ttaccttcta gctaaggaca aaatgctatt tcagaaaaaa tggaggaaaa 180
atacatcaag tcagtcccct g 201
<210> 972
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 972
aggaagactt aggagtgaga gactttaggt tcgaatcctg attcccacct tctgcctcca 60
cacacaggga agctgtgtgt gatcttgcac aggttatgca nactctccca aacctcaatt 120
tcctcattag ttacaatacc tttcttatga gattgggtga ctagtaaatg acacggcaca 180
tagtaggtct gtagatcttt c 201
<210> 973
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 973
cctcggcagg tggaggtgtg aatgttgggg gccgccgaac actaggaagt gtcctcatgc 60
atcacaatta cagaaacacc tgtgctaaat acctttgtgc nggttggttg tgcaaattca 120
cgaggtgttc aattgcttcc aaatttctta tttctacact gtcaacaagc cgcaggtgtg 180
cacggcatga gccgccgccg c 201
<210> 974
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 974
tgtgagatgt ggacaatagt agctcctacc atcggggtta ttgaaaagat gagttgagct 60
gaggaatgga aaggactcag tgcacatcct gtgcattggc ngtgcgctat aaatataatt 120
ctcagtttat tcatttagca ccagggtcgg caaacttttt ctgaaaagga ccagatggta 180
aatatcttca gctttgcagg c 201
<210> 975
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 975
atgtacaaag agagaaaaag aaagatgttt attttaagaa attggctcac acaattatgg 60
gtgctgctaa gttcaaatgt gcagtgttgg ccagcagacc ngagactcag tagggcaaac 120
agtggggatg cagttccagt gtgagggcaa tctgctagag aattcccttt tgcttaggga 180
gggcagtctt tgtgttccat c 201
<210> 976
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 976
atgtacgctt gtataaccaa cacacattca caaaatgatc aactttcatc aatgtagaaa 60
gtttcttctt tctccttttt caggtagtca ccctccaggc ncaggtgacc attggtctag 120
tctctaatgt tatagattag ttttggctgt tcaataacct catttaaata cttacataat 180
gtgtttgtct tattattgaa g 201
<210> 977
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 977
ctcagcctga aatatgcccc tttcagttta tcctctattg agaactgaca gagatagctc 60
acaggacact ttgtttccag gacccattca gtgactttat ncttatcttt ctacctttcc 120
ctcatcatgt tctgtgattc caaaacaatg gatatactca gaggttatag cacttatgta 180
tgcactgtac tgattccaag c 201
<210> 978
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 978
ccagcttgac agccatgtaa gtgagccatc ttggaaatgt attcaccaga ccagctgggc 60
tgctgatgcc tcatgggatt gagatgagca caccctgtta nactctgccc agagtataaa 120
gttgtgagac aaaaatgtga ttgtttttat tttaagccac caaattctgg gtgatttgtt 180
atatagcaat aggttacaaa a 201
<210> 979
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 979
tagatggtca ttgaatgata gaattatttt gtataaaaat atttaattac attttaaaaa 60
acactgtagt cttctttaaa agattattgg ggtcaaaagt ntgataatga taacttggtt 120
gatataaata aaggtataaa agacagaatt ttggcccaaa tccagaagca ctctggctgt 180
gagtgaccag agtttgaata t 201
<210> 980
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 980
agtgggagga tttgcgaaga agctgttttt atttggctgt ctcagctgtt tgagcagaag 60
tatgtttttt aaacaggttg ctggaaggtt cacaaagtaa ntggaaggcc tagcatcttc 120
ctactgcacc aagtctgggc ttccaagaac agtgacccaa actgcactgc agaactggcc 180
ttacaatgaa cccacaaccc g 201
<210> 981
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 981
tacatagtgc attcaatgtg ctcagggtgg cagagctata aaccagaagg aatctgaatt 60
cttgatgcca tccctgacca gttatgctct tcctaaaagc nctccttcca gactttcttc 120
gcaaatgagg aaaagaaact cctgcttaga taagcccctt gatatggttt ggctgtatcc 180
ccactcaaat ttcattttga a 201
<210> 982
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 982
aatgcatcac tacatcctgt tctaggtaca aggactagaa cagcagacaa aataaacaaa 60
aatcccaccc caatggagca tacattctac tgagggaaaa nagataataa acaacagaag 120
aaagaaaaat atgcagcatg ttaggtagag ataagagcta ttaaaattaa taggtcatgg 180
ggaagagaag aaagagtaga t 201
<210> 983
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 983
ctagtttcat gggaagatat ttcctttttc accataggcc acaaagacct cacaaatatc 60
accttgcaga tgctacaaga ggaaggtttc caaactgctc natcaaaaga agggttcatc 120
tctgtgagat gaatgcacac atcaaaaata agtttcctag aaatcttctg tctggttttt 180
atgtgaagat atttcctttt t 201
<210> 984
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 984
caagaggctt tgattctagg ctttctgttt cttgtccact tttttctatc cttctgctaa 60
caccatatta tgtttagata atttcataat aaatactgat ntctgttatg tcgtgttctc 120
ccttcttgct tttcttcctc agaaatgtcc taggtagtct tgatcttaat tatccttata 180
aattttagta ccatcaagtt t 201
<210> 985
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 985
gagcagagta ttccagaaaa ctggaacaaa acttgcgaag gcctaatatg agaataagac 60
agagattttc cggcaagtga aagagtgtca gtgttgatga natactatgg ttgtggaatg 120
tagtcaggga ggcagaaaga gagaacaggt caagtagggt ggtagtagct gtgtaaaaca 180
agtggatttt cttctacttc t 201
<210> 986
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 986
gaactatgat ttagatcaca tttctcagaa tcatccaagg atgacttgca tcagaattaa 60
ctagctggca tcttaaaaat tcagattcct gaacctcatc ngggattcat tgaatcaaaa 120
tctctgggga ttttagcact ccaagaaatt catatgtgaa ccaaagtttc agttgttcat 180
ctaataaaat acgatgtttc t 201
<210> 987
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 987
acttaccagg aactatgctg agtgtgttat atacattatc taatgtattt ctcacatcaa 60
ctctgggaga aatgtattat tatggcagtt ttactggtga ngaatctgac cagtaaaact 120
atgtatttta aggcaaattg tatcatttgc cttaaaatta tatcatttgc cctgaaatgc 180
atagctagta aacagcagag c 201
<210> 988
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 988
ctgtcctttc ttgctcatgt tgccttcaca catgctgttc ctttcccctg gactactcct 60
cttccctctt ctctttgttc cttcacctgg atcactccta nttatctcaa gtcttcacct 120
agatggaaat ttctccagca tcctcctcaa tctttccaaa cttctaaggg ttaggtgccc 180
tacccatgtg gtcttgtagc a 201
<210> 989
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 989
gcccaccccc tgtgctcaag tggtaacccc tgctaagaat gtgcctaggc cttagaatca 60
gatttagatc agctgaggca cagcagggat gagaaggcac nctgaaaacc aagcaactgg 120
tggagaattt aatacaggga ctatttacaa caatgtgagc agccttaggg aaactaacag 180
gagatggggc agagcaggcc a 201
<210> 990
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 990
atataatttt acaacttcta tttctcattc aatatttttg aagagctacc cataatagta 60
tgtattagac ctaccctatt ctttttaact gatgcatatt ntcttgtcat atgactacaa 120
tttatttgag tgtaatacaa tgtatctgtt catcaactga taggaatctg ggacatcttt 180
gtacgtacca ctttgtgcag t 201
<210> 991
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 991
atcagagcaa atttcacttt gtggatattc aatatgtatg catatattta tctagatcct 60
gccttgttct aaaaagattt gaagtgcctc gtgtgttcaa naaacgtgta caatgaatta 120
atcaattaat gggctaatgg atgtgagagt gctttgaaaa gtataagatg aaacagatat 180
atttctttat gagaatagtg a 201
<210> 992
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 992
ccctttgcaa gagaactagt gagagaggga ctatttgttg atactcagta ctgtccccac 60
cattgtcagc tctttcctgg tatacagggc agacagccag naaattatct ttcccagatg 120
cccttgacag cctggtccct gtaagggtcc accaaggaga tgcacttgtt caagatgtaa 180
aagatggaag agaagaataa g 201
<210> 993
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 993
ggatttctgc ttttgtgaag cacccattca cagcttttgt tcatttcact tcgtattttc 60
tatattttcc cctattctgt atgcatgccc tttgccagtt ntataaatta cagagtcttc 120
cactttgtct attttttttt gttcactttc ttcatggtat cttttcatga gcagaaggta 180
ttctttccta tcttaggata a 201
<210> 994
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 994
tcttgatcct cctggcatgg aattccccct acgaattagc tgggtttagg gtgattcaaa 60
cccccgtatt cctggcctgc agcacatgtc ttaaagcttc ntctctgagt aggatctgtg 120
tgggagaaag gaaattggcc ctctctaaat gtccgctcag aatagagctt catcgacatg 180
gggctggagg ggggcaaaca c 201
<210> 995
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 995
agaaatgcag atatgataat gaataggaag tcagtatttt tttttccata tacttctgtt 60
ttcttttcta aaaagtggga agtgagatta tttgttgtgc nttgttgaaa ttatggggga 120
aaatggtgga atgtgaatgt atcaagttta gtcaggaaaa cagaaggcat ctttattcaa 180
atgcaagaat gagggatttt a 201
<210> 996
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 996
aaggtctgtg ttgatgtaaa tgccagagag gtataatgag gcatgttcga cccccacttc 60
ctgtcatggc ctgaaacagt ctctcagttg gtaaccttta naagagccct gtctgcgcct 120
gggcacagtg gctcacacct gtaatcccag cattttggga gactgaggtg ggtggatcac 180
ttgagctcag gaatttggaa c 201
<210> 997
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 997
agaaaaggag atatcttaac ataaaaacta cacagaggca ttctgagaag cttctttctg 60
attgtgtaca ttcaactagc agagctgaac ctatcttttc ntagagcagt ttggaacctc 120
actttttgta gagtctgcaa gtggttattt ggagcccttt gttgccaaag gtggaaaagg 180
aaatctcttc acataaaaac t 201
<210> 998
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 998
caaaatagtt ccttacgtac tgtgggtaca taccaagggg tcttcaaaaa ttcatggaaa 60
atgcactcat gaaaaaaact atgcatgcat tttaattttt nggggatcaa aataaactca 120
tactaacttg ttataatatg tctaaacagg atctagccga tgctctaaga aggataagac 180
atcagtttga aaagagccct t 201
<210> 999
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 999
ggaaacatgc tagcgggact ctctcttgct ttgctgagag ttatttttcc attatccttt 60
tcacccagta aattccattt tcctcaccct tctttatgtc ngcgagcctt atctttcctg 120
gtcgtatgac aagagactgg ttttagccaa actaaggaga aaattctgca acggtagcaa 180
gagatagaat ctattactgc c 201
<210> 1000
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1000
aaattaatta gtaaaagtta gaaaaaatat taaaaataaa tattaagaag aaaggttata 60
gaatgataaa atagtgtctc agattgtgtt ctccaggaag nagacaatga aatggaggta 120
ggagtgcaaa aggtttatta aagagtaaca agtgtgaaag tgtaagggaa agaagcaaaa 180
ttgcacaggg ggagccatca g 201
<210> 1001
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1001
aaagggttgc aacacgatga aggttcaggt gattgttagc attttttttt ttagcaatag 60
tgtattttta aactaaggta tgtacacttt ttagacattt nctatcacac acttaatgaa 120
ctacagtaca cagtgtaaac ataactttta cgtgtactgg aaaaccaaaa actttggttt 180
tttatgcttt gttttgttca g 201
<210> 1002
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1002
ctctgtctca aaaaataaat gaataaataa ataaataaat acaaaaaaaa gaaaatgaaa 60
aatagtacca ctttggaaaa ctgcttggca gtctctttaa nacttaaaga ttggcctgaa 120
gttttttgtt gttgttgtac ctccgccagg ttttagtatc agaatgatgc tggcctcata 180
aaatgagttc ggtaggagtc c 201
<210> 1003
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1003
ccaggtataa aaatggcaaa gcatttgata ttgccataca tgtctttgag gctcttttaa 60
atttaaatct ttcttttctt tgagtttcag cttggaaaag ntttacttga tctcatattt 120
actgtctctc tcatcagtaa tatttaattt tgctatatag taccatctgg tggtactaaa 180
aattttaatt tcaaatgttg c 201
<210> 1004
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1004
gttcatacta catatttgct actttgcata ctttcaccta cattttccca tttactccct 60
tcatgtcaac cctgataatc actatttatt ctctatgtgt ntatatttga acattttttt 120
ctagatttcc cttataaatg agatctttgc tgacatatca gcctctccaa gaaaacttcc 180
cttgccacct tcctcatagc a 201
<210> 1005
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1005
tctgtgtctt ggacagtcac gggacaagat ggtggatccc cgcaccatta cccttcagac 60
ccagggctta tataccgcag ggaaagtgtg tacatgcttc ncaagggagg cttaggtcaa 120
ttgaagtacg gtaacatcaa gggattacac cttgggaatt atggtaaata aatttaggct 180
ttatagtaag tccctgctct t 201
<210> 1006
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1006
ctcagctgtt tcccttgcac aagccccaga atagagcctc atcgaggaaa catgcttggc 60
ttgtgttgat ttctattacc tggggaatct aagagcccat ngtctgtaac acaggtactc 120
tatactatct ggggtggtca tctagtctaa atttaaatgc atcagaatta gggaacttta 180
ttatatgctg ccgctactac t 201
<210> 1007
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1007
cctagagcag gagaagatga atgttccagc ccaagcagac agaagattta tccttcttct 60
accttttcat tctgttcaaa ccctcaacaa attgtatgat ncccatctac attggtgtga 120
gtgatctttg cttcatctac gaattcaaag gctgatctct cccagaaata cccttacaaa 180
cacacctaga cagaatgttt t 201
<210> 1008
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1008
ccagttatat ggtcaacagt ctagatgttg ctgtgaagat attttaggtg tgattaacat 60
ttaaatcagt agactttgag taaagcagat tactctgcat ntggtgggtg ggactcatct 120
gactgagatc cctcatggaa aagggaattc cactttcaga ctgcctttgt attctggact 180
gcagcatcaa tggttccctg g 201
<210> 1009
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1009
ctgagtctga gcctctggag gcagctgggg tagcctcctg tccaagcctt gccagggatg 60
gataaattgg tgcacagggg gtggactttc taacacttca ngttgggcct gtaggacagg 120
ttttttctgc ttttcctgta actcctattc tttttctgat gccttgcagc ctctttctat 180
tgtccctggt tttgtctggg c 201
<210> 1010
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1010
agggaaagtg ggatccttaa ggtagatccg aattggtatg gtggccgagg ctcagtcagt 60
ttttcattga cttacccaaa cttctggatt aatatcggtc ncaaccatga ggagacagag 120
agtctgtcca ggagccataa gaatagtgat tcccatatga gctaaaatgt cccttcttag 180
cagagaagtt gggctttcag g 201
<210> 1011
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1011
ttttaccatt gttcagggag aaactgcttt gggaactatc ccagtgtcct ccttatttga 60
tacaagtaat aaaatcctca tgctaaatac ttcttggttg nggtcattgg attgtcaatc 120
gccaagtgat caaagcccac attgtgtaac aatttctgta caataagtta ttttaagaga 180
gagagagaga tcacattaac a 201
<210> 1012
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1012
atcatcttgc accagcctaa atgactatta ctaaaatgtc agaaaataac acatattggt 60
gaggatgtga aaaaagggaa ctcttataca ctgatggtgg naatataaat tgtacactgt 120
ccatagaaat taatatagag atttctcaaa taactaaaaa tagagctacc attcaataca 180
gcaacttcac tacttgatat c 201
<210> 1013
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1013
actgaaacaa taaagaaaat gaaagtcaaa caccacatgt tctcacttat acattggagc 60
taaataatgt ggacataaaa tatggaataa tagactttca ngctaggata gagaaggaga 120
aaggaggtgg tggtgagaaa ccagttaatg ggtacaaagt acatggtttg ggtgatggat 180
aaactaaaag tcaagacttc a 201
<210> 1014
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1014
atccgcccac ctcagcctcc caaagtgcta ggattacagg catgagccac tgcgcctggc 60
cacaaggtga tgtttttata tatgttttgt atagtgatca nttcagtgta attctgtatc 120
tatcatctca aacattattt gtttctttcc attggggacc ttcaatatgc tcctactatc 180
tctttgatac tatatattat t 201
<210> 1015
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1015
tctttccatg ttttcatgtc tctttcccat tagactaaaa tctttgagaa caagtattac 60
tgtgtaacac tgagtgttgc aatcccacag ccttgctata nacatattac ccaaaaggtt 120
ctcagtaata atcctgtaaa gaaagtaatt catttctgat atttaaacac cacactgaaa 180
agccttgtac tgtgcttact c 201
<210> 1016
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1016
ggactaatac acaagaaatt tctttatggg aaaattatga gggaagtata tagctttttt 60
taatctttgt agctatctta tttaggaata aaatgggagg ngggcttgtt ccatgcttga 120
ctttcatttg gcttcctgat tttggggtcc caagatttat tttcctttca caaaacatat 180
aatacatgca aagcaacagt t 201
<210> 1017
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1017
tcttgaatat aaatggggtg gggcataaaa gattttgcag taatttaaag atgaaatgaa 60
ggttggaata ggaagtagta gcaaagaggg aaacagtgaa nagaattaaa acatattttg 120
gaggcagata agttcttttg cagtttggca tatctctatg tcaaaacctg tgaaggacta 180
agattttttt ttctactggt a 201
<210> 1018
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1018
agataatttt gtccaggatt tcaattctgt cttgattttt tttagaggtg gagtctcact 60
atgttgccca ggttagagtg caatggctat tctcaggcat naccatagta cactatactc 120
tcaaacttcg cattgaaggg atcccaagta gctgggacta caggtttctg ccttgaattt 180
tttaaccaca caaattaggt a 201
<210> 1019
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1019
atatgaattt taggattttt ttttctaatt ctgtgaaaaa tggcattggt aatttggtag 60
aaattccact gaatctgtag tatcatgatt ttaatgatag ngattcttcc catccatgaa 120
catctcgaga tgttctctta tttgcttgtg tcatctgcaa ttcctttcat cttgttttgt 180
agttctcctt ataaagattt t 201
<210> 1020
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1020
attccagacc agtacctgtg gactaagact ccagaaccgc caggtggagc catatagccc 60
ctggcttccg gcttgcatga cagactcaat caatctctca ngttttatgt gtctgaaaat 120
gtctttattt aaactttgtc tttcaaatat attttttgct gcataaggat tttagtatga 180
ttgctttctt tttatatttt a 201
<210> 1021
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1021
gtgtttcagt gggagaatcc tctattggct taaatttgcc tgggtggttc ccaaactgtt 60
ggatgaatag agcatcctag gaagcttatg aaaaatgtct ntttctagac agtgtaattc 120
aataggtcag ggtgagttcc agggattagc acccgtgtga tcaacagccg atggtcctca 180
caccacatct tgagaaatct g 201
<210> 1022
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1022
acaaactgca ggtccccacc ctcaaagctt ctgattcagc agggctgggc agagtctgat 60
aacttacttt atgtaacaag ttcccaggtg atgttgatgc ngttctttgg gaaccccact 120
ttgagaaccg ttgctcttgg gtattcccat tgtggccacc agctggttaa gagtcagact 180
ttgacaaata ccaaatgtta t 201
<210> 1023
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1023
tctgattcag cagggctggg cagagtctga taacttactt tatgtaacaa gttcccaggt 60
gatgttgatg ccgttctttg ggaaccccac tttgagaacc nttgctcttg ggtattccca 120
ttgtggccac cagctggtta agagtcagac tttgacaaat accaaatgtt atgctccttg 180
ttctgaggtg tatgaggagg c 201
<210> 1024
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1024
tacctaaata attaggtatt ctggaaaagg aggggatgat ggagaccgtg gttactgcca 60
cctttctctt tcacttgcgt ttgtctgaag agtcatggac ntgtcacctt aactgaagtg 120
ctggccattt tctctccctt attttgggtt ttctgttatt ctgtgatttc tttgcctagt 180
tcttgtttta gctgtttggg t 201
<210> 1025
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1025
tgtggtctgc cctgtggact catgataact gaggtattac tcaatacata tggcatttca 60
ggcaatatgc tggtaccata cctgtatttc atggtctgaa ntactttgca ccagatctca 120
gttagacata agcttctttg caaaatcaca ggacttcaat gcttctttag tcttctcttt 180
tttttttttt ttttttttgg a 201
<210> 1026
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1026
tttgcttatc ctcttgcttc ccctctgagc ttaatctccc ttgcatttct cctgaaagat 60
tgcaaaatat tactaggtta tgttctgtcc ttaaccaaga ngaatcattt taagactcaa 120
taaagtttgt gtgaattctc tctttaaaac ctccaaaaac cctctattcc cagtagaata 180
aagagtaaat caagaatgta g 201
<210> 1027
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1027
gtgtacccac ggacattcag agtggattca taaacattgg aggctccaaa cagtgatagg 60
gtgggtgagg gggtgaagga tgagaaatta ttaacaccta ntggatacag cgttcgctat 120
ttgggtgatg ggaatactaa aagcccagat ttctccacta gacaatatat acatgtaaca 180
aaactactct tgtaccccat a 201
<210> 1028
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1028
ttctccccag tcttccctcc cctttccaaa agcagaggag tctcactcca ttgccatcac 60
caccccaggc cacaaggagt actgccagcc tacaaacaat nttcccttaa ggcccaaggg 120
ctcttcagtc atcttgtggt aaataccacc tggactttga ctcatccttc agggtagtga 180
gatcccctct ggcccagagc a 201
<210> 1029
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1029
gccccagaac atggtctttt taggaagtct gcagcctgct gcggtggcca gtggggattc 60
caggcaagtg ggttttagcg tgtggggacc catgggagca nggccgcttg gctccctggc 120
ttcagtactt ttcccacgga agtggacgga tctcctgcct cacgggagtt cccagagcgc 180
aggatgcaga tactcctgtg t 201
<210> 1030
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1030
tgaagaatca gaaaatcagt gtcttttctt ggatcagcca gacgtctcag ggcaaagtgc 60
ctaccaaaaa ctagagagac agataaagac ataaacagac ngtgcctatg tgttggcata 120
ggggggatat ggaaagtctg taacttctgc tccatttttt tatgaacctg gaactgctct 180
aaaatgaact ctagttaaaa a 201
<210> 1031
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1031
ggttcttata ttgacttctg ctttcaatct gcttcaatat gttgttctga gtgaagtata 60
ttaaggaaat atggcctcat acagatatat agttggcaga naggaatatt tacttgtctt 120
ttcagataat tcaagatatt cttcttggat gctataccta aactcattaa gtggtagtat 180
cttaagcttg ttgctatgta g 201
<210> 1032
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1032
aactggatat gaataaggca actgttatgg gtaaggctac cttgaagcat attctacact 60
agagctgtgc aggatgttta tttgggagtg ctctagagat naattccatg caagactaaa 120
agaaacagaa gaagaattga gcagaggagt tatagatgta gcctcaagga aggccttagg 180
caacaccaca ggaaactccg g 201
<210> 1033
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1033
tcagcagcta tttagaatta tctacatttt ctattgttca aaaattcatt gttatgtcta 60
gtttttcagt tctctctctc tctttttttt tttttttttt ngcttgtttg gttgaaaccc 120
atcctcataa ttctttcaga aagatttgtt cgtggctaca gttttgagct cgtttcaaaa 180
atgtttttat tttgctctca c 201
<210> 1034
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1034
catcgatgta cagccattta gattgtgcac tgagtaactc tgggtgccat ttacatcata 60
gattatgagg taattcatat tctttggttt tgtgtaaggc ngtagctctg gttatcatca 120
ctccctgaag tgtttctcac ttaattgaat gtgtcaacat taacatttca aagataagat 180
tgagtctctg gatgatttct g 201
<210> 1035
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1035
cctcctgcct cagcctccct aacatgctgg gataaccaga gtaagccact ctgtctggcc 60
aggaatgtct agtcttctga cagaggaaaa agagatgata ncgaatcaca tactggcctg 120
caatggttct gctcatggat gacaggtgtt actttcactc aaatgtcatt gggaaaatca 180
aatcatgtgg caagagtaac a 201
<210> 1036
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1036
gaggggatgg acaagattta tttaaagtgc cactaaactt gctatactca cttgagatgt 60
agctatgttt tctagcatta ttctgggatt attcttgaat nattgcagtc ttttgattca 120
ttttcaaaat ttcggaattg ttgatttcgt aaaaattcgg ccattattct caatactttt 180
atgcagaaga agacttttgg a 201
<210> 1037
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1037
ttttttcaac aagtgtgttc tgatagtcca ctatttgtgc aaagtgctga ggatacagtg 60
gtaaatataa taaatacagc ccataacctc atagaggtta ngctcttaca gatgctatgc 120
aggtatgggg gtgaacatct tctaaaatga ggctgaatta gaagatgatt tttagacaga 180
tgtcctaagc taagattata a 201
<210> 1038
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1038
tttaaaaaac tgaagagaag ctttttactc cttttatata ttttccctga aacttttagc 60
caccacagtc atcaaccatt gatcattttg cagacacaca nacacacaca cacacacaca 120
cacacacaca cacacacaca cacaatgtca gttacaggtg aaagcataag acgaagacaa 180
aaatgtcact tctttccatt a 201
<210> 1039
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1039
accatatctt aaagcattta cctggtagca gggacataaa ttcaaacttt gtcaccaggg 60
accagtttct tggaaggcaa tttttccatg gggggaggca ngaatagttt ggggatgaaa 120
ctgtttcatc ttaaatcagc aggctttaga ttctcataag gaatgctcaa cctagatccc 180
ttgcatgtgc agttcacaac a 201
<210> 1040
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1040
cctctgtcac tccatctgta aattgggaat tatcattgtg actacttcac agagttgtca 60
tacagattaa taagatgatg tatgttttta cactcaatat ngtacccaag atgcagaaag 120
tattcaataa atattcatca taatgatgat gattctcaat aaataaataa ataaataaat 180
aaataaataa ataaataaat a 201
<210> 1041
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1041
acttcatgtt gaattttata agaaactgcc aatctgtttt ccagagtagc tgtaccattt 60
tacatttcta ccagaaatgt gtgagtaatc tgatttcttt ncatcctccc cagcatttgg 120
tatttcacta tttttaactt tagccattct gataagtgtg tagttatatc tcattgcggt 180
tttaatttga cctccccaat g 201
<210> 1042
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1042
gggttgggag gtatcttgct ttccagagaa ggcaacattt ggtgagagtc tccagagtac 60
aattaattgc caggttgaga aaaaggtgtg aatggtatag naggcagagg aaacagcatg 120
tggcaagcca ctaaaatatg aactgaaaat acaagttttg gagaatgttt ttcattcatt 180
gtggctggga ctagtagatg g 201
<210> 1043
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1043
atatagagga agaaataaat gaatagtaaa acaagacaat aattgaccat atatgatgat 60
gcaccatagg ctaggaaatt tgactagctc aacttatgct nctgagatcc aataaataaa 120
caaagtatca attaaaatgg aagtgtttca ggcaaaggga ataatgtgca atttgcagaa 180
gtaatggagg acatgataca t 201
<210> 1044
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1044
tgtacagatt gtttcatcac gcaggtactc agcctagtac ccaatagtta ttttttgtga 60
tcctctccct cctgccaccc tccaccttca agtaggctcc ngtgcccatt gctttcctct 120
atgtctccat gtgttctcat catttggctc ccacttatga gtgacaacat gcagtatttg 180
gttttctgtt cctgtgttag t 201
<210> 1045
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1045
aagactaagt tcattgaact tcccaactcc tccaacttaa atggggccag gtgatttcct 60
tcatgtagtg aaatgtgaga agttacctgt gactcccaga nagaagaagc ctttaagatc 120
cagtgtgaaa tccaccatat ttccttccct tccttggtga ttggaagcag cccaggtgct 180
gaaaacttca tccatcaact g 201
<210> 1046
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1046
tattccatat gcactgggct ccttgccctt ctttgtctgt gtcaggcatg ttctagccac 60
agagctttaa tccttgctgt tccctctgcc aaagaacgct ntttctcata gaccagtgtg 120
gctagctccc tggggtcttt tcccaaatgt tgtctcttcc accaggcatt ccctggccac 180
cctacttaaa ttgcaactcc t 201
<210> 1047
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1047
gccaagatct tccagaagca actgtaggtc agagtggtgg gagaaattgt aggaaaaacg 60
caaaccttct tggaatgcca gggggttttg caaagctttg ngggagaatg agccaaaggt 120
ggcggttctt accctggggc aaagggtgag aagtaggtac aaaagaaaac aggggagttt 180
atctgaatag cttgtttact c 201
<210> 1048
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1048
gataaacata atgatagggt aaatcttaaa taataggatt aaataaatta aaactctcaa 60
agtgcttaaa acaagaacta gcacatagtt tgcaagcaat ngataaatac gaataaaatt 120
tatttgacat ctattgtgtt ctaaataatt taaagatacg acctaattta agctacacta 180
ccttcttgag aggttactgt g 201
<210> 1049
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1049
accatgttgc aaaagaaata cttttatcct ttttgatgac taaatattat tccattgtgt 60
gtgtctgttt gtgtatgtat tccttttttg tgtttgtttc natttagtgt gtccacattt 120
tctttatcca atcatccact gatgaacact taggttgatt ctatatcttt gctattatga 180
atagtgttgt gataaacata t 201
<210> 1050
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1050
ggctattcag ggaaacaggc ttagctttaa aaaactgtcc ttttgtaaaa gaaaactact 60
tctagaaaga aaatctacat tagtgaagca aagagtggat nctgtctttc tcttaaagcc 120
cctcctctgc cttatgtgga tctaggaatg attaactcac aggaaaagga aattaagagt 180
ctaacacatt ttaaggtctg a 201
<210> 1051
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1051
tcattgttca gcttacactt attaatgaga acattctatt catcgcaagt gtcactaagt 60
acaggcccca cttgagggca ggagaaatat aagaccatga ntgtcgtaga gatggaaatt 120
attggtctac tttagagact gtcaaccatg atacaagttg ccttaatata taagatattt 180
caataaatgt caattgaaat c 201
<210> 1052
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1052
ggattccaat caacaaatta agctaatttc ttattaatta aactcattga gggcagaagt 60
tttattcaat gagtccccaa catagttaac tgagttcata ntaggttgtg aataaataat 120
aaatcagaat aagttccttg tgaatgggca aaaacacagt gagtttgtac ctgtggtgag 180
attcctgtct caaaacttcc a 201
<210> 1053
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1053
agcaaaatat ccagccaaag tccgtcttgg atgttcagac ctatacatct ctgtcttccc 60
ccatctcctg ttagaagttt ataatcatca tacattttac ntaagccaaa gaatgctcat 120
aatttttaca ttctaactct agcctgcttc tctcctatct tctcccattt ccttgagtgg 180
tatcactacc actaatgtta c 201
<210> 1054
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1054
ttattgtaga atctttcacc tccttggtta ttgtgtatat atgccatttt tggtagctgt 60
tgtaaatgga ttgttttctt gatttcttta ttagctagtt nttggtgtat agaaatacga 120
ctgatttttc tatgttgatt ttgtatcctg taactttgct gaattttttg atcagttcca 180
agattttttg gtggagtctt t 201
<210> 1055
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1055
ctacagcata acctaactta tgctgacttc aatactttgc aagcaggaaa aaagcatggt 60
tgtgaagaga ttttaatggc acgtgtatta gtttcccagg ncttctgtaa caaagtacca 120
caggctgggt ggcttgacca acgggaattt attgtctcat cattctagag gctggaagtc 180
tgagaccaag gtgtcagcag g 201
<210> 1056
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1056
gaaaagcatg aataagcagt attggaatgt ttacaatttc tatgtgaggt tcatgagcat 60
gggaaggaga aggagaagat tctaagacta gtggttccta nagtatgtcc tccagaagac 120
tggcactatc aacattacgt gataatttgt gaaaaattaa aaattttgag ctcctcccag 180
acctactgaa tcagaaactc a 201
<210> 1057
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1057
tgtctgtagt ctttaaaata ctaagacttt ggttttctca gaagaagtaa aacaaagaca 60
gatacataac attaataatt tgattagtag acatacaatg nacaggagga ttacaatcaa 120
aagagaattt gtaagccaga acaacaaaaa caaaagagaa cccattcctt tagggagaaa 180
actaaaagga tcatgaagaa a 201
<210> 1058
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1058
ttgaagtatg ttgcttctat acatactttg ttgagggttt catgaaggga tgctgaattt 60
tatcaaatgc tttttccata tctattgaga tgatcatgtg ntttctgcct ctattgagat 120
gatcatatgg tttttgtttt taattctgtt taaatggtga atcacattta ttgatttatg 180
taggttgaac catccttgca t 201
<210> 1059
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1059
tagcagtgac cagtatggag gacattagag gagtctctct gaatgctctg cttaacataa 60
aattttaaag aactgcagga ggaggagttg ggtggagtga nagcccacaa tgactgagtg 120
aatttgcctt caacctggca acatgggtgc aaagtcagat ttattttaat ttaaagagca 180
caaagaagaa ggatatttct t 201
<210> 1060
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1060
atggcattgt aagcagcaga cactcttggt agcaaagtat gaggagctca aaaaaactgg 60
gatgtgtttt gtagagatgg agaatggggt accagttgtg ngtgtgtgtg tgtgagagag 120
aggcagggcc atgactagag tgaagcaagt gaggcctttg cctagtgccc caaatttaag 180
tagacaacag aagaacaacc t 201
<210> 1061
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1061
gtaatacatt tcatttcctt tttaacacaa cttgaatttt atacacacta ttcagtattt 60
tgcatttttc accttatcgt ggaagtcagt cagtttgtct nggtatgtac agagcctcct 120
tctttttgac agctgaaact gcatactatt tcattcaatg gagttaccat ttatttataa 180
atcccctatt gctggatgtt c 201
<210> 1062
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1062
ttatttatct attgttgttt ttgttgctta tgcttttaag gtcttagcta tgaactttat 60
gcctagacca atgtccagaa gagtttccct taggttactt ntagtatttt tatggtatct 120
gttgttacat ttcagtaagt ctttaatcta tcttgagttg ttttctgtat atgctgagag 180
ataggggtac agtttcattc t 201
<210> 1063
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1063
caatagaaag aaatgcttga gttaagataa gggggcttgt ggaggccaag gttcttgtta 60
tgtagatgaa gccttatagg tagcagcctt tagagagaat ngatggcaaa tgtctgtctt 120
cataaattaa aggtgccagg ctctccatta gtctctccta gatataggta aaggcctaga 180
aaggaaaggc ctggttgcat t 201
<210> 1064
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1064
tgtgtgtgta tttctgcatg ctgttctaat ggattgatct gtttgcctca ttttcatgtc 60
aatagcacat tttaaaaatt actgtagctt tctgtccttt ntcaaaactg tttttactgt 120
tctaggtagg tccttcacat tccatataaa ttttaaaatc agctgttaaa tttctactga 180
aaaaagaaag ctgattgaga t 201
<210> 1065
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1065
tagcaataac aatctctgtc taggatataa gggaaaaaag tctttattat aaaagtactt 60
acactgggaa aacattctta aaagaccaga ttataaatag ngtaggcttc ctgagccagg 120
tctggccttt gttgtataac tctaatttct ttttgttttt aaacaactct ttaaaaagat 180
aaatatcctt aggtattggc c 201
<210> 1066
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1066
ctatcaccag aatcctttag ggctggtact ggcttcctga agttcctagt ttggctccat 60
cgtaatgcat tttttatttt cttagccctc tgctcacctc ngagaatgat ctttttatta 120
aactctcttc agcaaaaccc tttgagccta gaatcttgtt tattgccaga actttgacag 180
agagtcagag atgaagacag t 201
<210> 1067
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1067
ttcatacaag taatatattt gtccaaattg gacaaagtac agagaagagt cacaaaaatg 60
attgaggaga tggaggcctt aacatacgag gtgagattaa nagaatgtag tgtgtggagc 120
ttcgtgaagc tgctgctaag gagatacggt atcactgcct atgcctcagg gcatagcagt 180
aaacccccaa aggggaattt g 201
<210> 1068
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1068
atcttaaggc tatgaaatga ttctcccccc ttccacccaa catttcacca ccacatcact 60
gcagacttat ttacagctgt tcctattacc cagtacataa ngtctggcca tcaggaaaaa 120
atatatataa aatacactaa aaggaaaaca cagtttgaag ggactgaatg agaagcagaa 180
taacagatat ggcaggaagg t 201
<210> 1069
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1069
aaggcaattt tccttgggcc aaagggacat atttgagtta aacagactca aaacacatac 60
tcttccactg aatataatgt ggtgacatta cttctataga ncctacttct atgcttgctt 120
tgtttaattg ctctgatact aatgacacct tggacaaata acatcatttt ctgagtcttg 180
acctcctcac tttaaaatag g 201
<210> 1070
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1070
ggaatatagc gagacccttt ctctacaaca aataaaaatt agctgggcac tgtgcacctg 60
tagtcctagc tactcaaggg gctgagacaa aagcgtttat ngagcccagt ggcctgagtt 120
tgcagtgaga tatgatcaca ccactgcact ccagcctggg caaaaaagca agactctgtc 180
aatcaatcaa tcagtcagtg a 201
<210> 1071
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1071
agggtacttt agatccctag ggctgttgaa ttctaggatg caaaagagag agtatgcaga 60
actgagcctg gagctcagtg cttactttat tgagtgctta ntatatgcca ggcactgtgc 120
taccttaaag atattagtcc ttataacaaa tcataaggca gatactgtta ttgatcccac 180
tttacatatg gagaaactga g 201
<210> 1072
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1072
atatttatat acatatgtca gatatgtata gatatataac aattcatgtg tgtgtgtgtg 60
tgtgtgtgtg tgtgtgtgtg tataaagaga tttgtcatgc nattatggaa gttaaatctc 120
atgatgtttc ctctgcaagc ttgagaccct ggaaagccag tgggtacaat tcagtctgag 180
accaaagacc tgagaaccag c 201
<210> 1073
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1073
cattgcatac ctgtaagaaa tggccttgat ttatttcaac agggaaaaag aagcaaacaa 60
atggaatggt tcatcttgat accattaaat ctcttactct nactgtaccc ggaaaccatg 120
gttttccact tgttagaatg gaataacggc cctgcctatc tacggccaag ctctccagtt 180
ctgcagtgaa tcaaaacagt t 201
<210> 1074
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1074
agagacagtg taacaactgg ctgaccatcg cctgatggtc agctgacatt cctggtgtgg 60
tggggtgggg ccctctccct gccctgctca tgcctgacta nctgcctact gtaccgaata 120
tactactttg tttattcatt catttaatgg tgggcatttg gattgtttaa agtttagaat 180
tattacaaac aaagctacta t 201
<210> 1075
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1075
tcccaaaaca ataaataaat ggtttttaat gtgcaaaaac atgcacaaat aggcaaaaat 60
tcaaataata gcacatcatt tttcactgat taagatattc naacatttta aagtgttcaa 120
aattttatag cccttggaga aggtacaaaa aagctgtgca ccaatgtcct gttggtgtga 180
aatgtgagaa aggcgtacaa c 201
<210> 1076
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1076
agatatttag aatttgatgt ctacttataa atatctcccg gattagcatt tgatcttccc 60
agagatgaag aataatgatt tatcccaaag agaagctatc ntagaggaaa tttcaagtat 120
attggtaatc tggggtttgc agcgtctctg aaaacacacc atatgctatc cacctcttct 180
agttaatatt ctttctgatc a 201
<210> 1077
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1077
tttttcatca gaggctacct gacctggagg aagagaaata accaggccag ctcctttagt 60
tcaccctgtc cttcctaaga aggcaaagac tgagaagcac nggtgaagca cacagtccag 120
gggcacaagc tcaccaaaaa gctgacacct aatcacaaaa ccacagaaca cttctgatgc 180
agtttggctc tgtgtccaca c 201
<210> 1078
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1078
gtctgggaaa ctgctttgtg atgagagcat tcatctcact gagttaatcc tttcttttga 60
ttgagcagtg tggaaacact gtttttgaag aatctacgaa nagatgtttg ggggaacatt 120
gaggcctata gtgaaaaagg aaatatcctc agataaaaac tagaaagaag ctttctcaga 180
aatggcttta tgatgtgtgc a 201
<210> 1079
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1079
agtggagact ctctgtaggg gctcccatgc cacatttccc ctctgcattg ccctaataga 60
gtttttccat gagggctttg cccctgcagt acacttctgt ntggacatcc agacatttcc 120
atacatcctc tgaaatctag gcagaggctc ccaaagctca tctcttgtct tctgtgcacc 180
cacatgccca acaccacaag g 201
<210> 1080
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1080
ggaaagagtt tttcaaaagg atatgaaatt attaagcata aagtaaaaga ttataaaatt 60
tgctttgcta aaattaagat taaaaaaatt aaaagacacc ntaagaaaaa tgaaaagtca 120
agccacagaa tgggaagaaa aacttgcaaa acatatagct aacaaagaat taatacccaa 180
tctatgttaa aaaaataaaa a 201
<210> 1081
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1081
tggtccatta ggaacactca ctcattcctt gaagaaactc ttgacacaag ggctaatcta 60
gcctgccagt ttctctcccc atctgaagaa ttagctggca ngattcaggg acagctcact 120
gtgtcccaca aggtctagag ggcacacttc aatctctgca ggtggtcctg tgaaagccca 180
tctcagttag gtgcaaggtg a 201
<210> 1082
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1082
atgaattatc tttcaacaat ttagattcta tcacatcact cgcctgattt aaaattcact 60
ctgtatggta gcgattctca aatcacatgg aaagcttgtt nacacacacg ttagccgacc 120
cacctcccaa ctctcagatt cagtagatct agggtgaagc ctgagaatgt gcattttgag 180
tgtattcaca agtgctgctg c 201
<210> 1083
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1083
ttcaagtaaa tgttctattg gcttagagtt gctcataata ttactttata aactgtttga 60
tatctgcttg gtctataagg actgatccat tttatccatg naattgatta cctgcacctt 120
ctttctttga ccagtctcac tgtctatcaa tttattcatt ttgaaaaaaa caccatttgg 180
atttgttgat cttctctgtg t 201
<210> 1084
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1084
gacaccagct atggtggcag caggccccag gtagggtggt ttcaagctct taggaagtgc 60
acgtgggtgc cagtggtggt ggcaatgggc cctacatggg ntgatcttca ggctcctgaa 120
cagtgtgcat agccactgat gttggcaaat tgggctacag gcaggctgat ctgtaggata 180
tgtgcaagca ctgctgctgt c 201
<210> 1085
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1085
taaacatcct ggttgcccca cccatatcaa gaaccagtgc atggccagca tctggaagcc 60
ccctgggtgg tctttcttca tcataaagtc ctccctaccc nccatgttaa ccatactact 120
aaatattctg aaattcactt ttttttacag tgtcactatc taattgtaga tctcaaaaca 180
ccatggctta gtctgttgcc t 201
<210> 1086
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1086
tactactaaa tattctgaaa ttcacttttt tttacagtgt cactatctaa ttgtagatct 60
caaaacacca tggcttagtc tgttgcctgt ttttgaaatt ngtatattga atcatacagt 120
aactttaaag tctggcttct tttactttat attgtaaagg tttattcacc ttttgcatgt 180
aactgcatat attgaagtct a 201
<210> 1087
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1087
gatcatacct aagctgattt gatgaatgga aaatatggaa gaaaggtaca ttcccaggta 60
aagggacaac acagggaaag gcacaaaaat atgaaatagc ntggcgtgta ggaaactagt 120
tctcaaatgt gttggcagaa gagatggcca gaagtgcatc ttggaggctc ttaaatatca 180
caacaagaaa ccttaccttt a 201
<210> 1088
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1088
ggaaagaaag cctcactgaa gagaattaag gggagagcaa gagattaaga aatgaagaca 60
gcaagaattg accactctat ttaagaaaat ggaatttttt nagatggaag atatttcagt 120
atgtttgtat gctcctgtaa gtaatctagt gtagggggca agagtttatg ttgaggaaaa 180
tataaccata gttgtaattc a 201
<210> 1089
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1089
catatataag caatatatat gtaatatata tgtgtgtgtg tgtgtgtgtg tgtgtgtata 60
tatatatacc tcattttacc tacctttata cctgtgccac nctgcattaa ttgtaacttt 120
ataataaatc tgtatatcag gtagaacaag cttatatctt ggtcattttc agtcatgcta 180
tagttatttc tggccatttg g 201
<210> 1090
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1090
ctatcttctc catcacatct acccctatag ttcaagggag agtatctctt ccctggatta 60
ttgcaatagc ttctcatctt gcctcatttc tacccggtac ntctccctgc agtatatctt 120
ctatgaagaa atcagaggaa ccctttaaac atgtaagtca gaccaggtaa ttcctatgtt 180
caaaatctgc agttgattcc c 201
<210> 1091
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1091
tacaggtctt tggaatcagg gccaccgctc cttgatgact tttggcaaga ggtcactctc 60
aatttcttcc acatggacct ctccacatct gtatggcagc ntacttcatc aaagccagca 120
aggggagttc tactgagaaa gcctagcagc aagaccaaag ttacaatctt acataacgtt 180
accaccgaag tggcattccc t 201
<210> 1092
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1092
ctccagcatt ccagtctccc tgagtcttta aatcttttct tctaccttaa gccaagggac 60
acgggacatt tccaactaac tcacagtagg ccattgttga ntcatttttc aactgacaaa 120
acaaactatt agagcctttt ctaacacccc aggctgcaac attaaatgca gaatctgtgc 180
ttagtgggcc tatattaatt t 201
<210> 1093
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1093
ccatttgtat atcttctttg gaaaatgtct attcaaattc ttgactcatt ttttaagtga 60
attattcgtc ttcttattgt gaagttataa aatttcttga nacattctga atacaagaga 120
atattgtttg caatattatc agaattgcaa acattttctc ccattctttg aattgccttt 180
taacttttct taatgttgcc c 201
<210> 1094
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1094
actaactata gaacagaggt aagttcctcc agctctgtgg gcttcttttc attcatccat 60
aaaataatgg aaatacacca actgtaccta cctcaaagtt nttatgtgaa cataaaacca 120
ttaaagcaaa tgacgggtgg ttgctgagcc tgacacacta aattctcaat aaaccatagt 180
tacccttgat agtattgctg t 201
<210> 1095
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1095
ggaaggaagg aaggaaggaa ggaaaatgac ccctgcatga tttcattaat ataaaattca 60
agtaaatgca aatgaatctt caatgacaga aagcaggtca ntagttgtct ggggattact 120
aaggatttga agaatatctg aggggtggta aatatgttat cttggttgtg gtgatgtttt 180
ttctggtgta cacataagtc g 201
<210> 1096
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1096
ttcaatttcc ttactcagca ttgcactgtt caggtttctg aattttgtga ttcgctctta 60
ataggttatt tgcttctggg aatttgccta tttcctccag nttgtcaatt ttttgacata 120
taattgttct tagtctcaca tgactcttca tatttctgtg ttacctgttg taatgtctct 180
tttctcattt ctggttttat t 201
<210> 1097
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1097
ggtattgcct aggttgtctt tcagggtttt tatagttttg ggttttgcat gtaagtcttt 60
aatccatctt gagttgattt ttgtatattg tgtaaggaaa nagtccagcc tcaatcttct 120
gcatatggct agccagttat ctcagtacca tttattgaat aaggagtttt ttccccattg 180
cttgttttta gcagctttgg c 201
<210> 1098
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1098
tttttctttt ttctattttc tcttaagatc aactgtacaa cactgtcata taaaagtccc 60
tcttctagtt agcccacctt ccatgccaaa aacctctaat nggagtatca ctgaagcctt 120
tatttctttt cattataaag ctttcccatt tatctgtctg tctctgagat tttgtcaaat 180
gcaaaaaaaa ggatgccttg a 201
<210> 1099
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1099
aaagactttt ccctgtagat gtgtcctata ctgtcagatg ggtaggatac tttggctttg 60
attctagatg gtcaatacag tgtagtttct atgtgatttc nccagctata atcagcttca 120
gcagtgtctg aaaattcttc agtggcctag gctgtggttg gttgtgaaga ctatgaagct 180
ttgcttagga tgggagcact g 201
<210> 1100
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1100
gactggtctg gtagtgacaa attagctcag catgtacttg tctgaaaaag actttattct 60
ccttcattta tgaaacttag tttggctgga tataaaatta ntggctggga cagaggtgga 120
gcatatggca gaatacaaga ctccagtgat tgcccccacc ctctgccaca aggacaccaa 180
tttaattatc tacacacaca c 201
<210> 1101
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1101
tgtaagtgga aaactggcat ttgaatgcag atctgtctag cttcagaatg caactttttc 60
ctccattaaa acccttgttt attaaagtaa agagtacttg ncaagcagta ggtaaaagtc 120
cccattttgc tactgattag atgattttag gtgaattaac ctctttgagc ttcagatttc 180
tcatctgtaa aatagagata a 201
<210> 1102
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1102
ttatgtgaca aaggtgaaag gattttacaa atgcaattaa aattcttaat catttgactt 60
tgaagtaatc aaagaaagat atcctgggtg ggcctgacct ngacctaatc agagaaacac 120
tgaaataagg tcctagaagc ctaagaaaat ttccagccgt cttgaaagaa actagtccct 180
gtgattttga cagtcatgag g 201
<210> 1103
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1103
agcttcagtt caaatgttgt ttttccatgg agaccttgct aaagcaaagc ttaccaatct 60
cctccttctg ctccaacagt acctgaattt ttattcacct nccatgcagc tttactcctt 120
cagtacattt ttcattgtgt gaaattacct gatttgtgta tttgtttatt ttctgtcttc 180
ctgtctataa tatagactcc c 201
<210> 1104
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1104
atactattta tccattaaag aaaatgaaac atgattctaa tttctgtctc tattattttg 60
actgttctag gtaccttaca taagtggaat catatagcat ntgtgttttt gcgactggca 120
tcttttactt ggcataacgg ttttgttact gaaacacaag cagtttggcc taggtccatt 180
gctcatcaca cagaaagtca a 201
<210> 1105
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1105
gaggaggaga gagccatggt ttatgcacca gcccaggtct gctcagagaa tgagaaccac 60
tagggaatac gcatcatgag gactgcaccc tacacagtgg nccagctagt cacttagtct 120
aggcaaggct gttgtttcca tgcctggtgc tagagcccaa aggccacagg gcatgcagct 180
gggaaaggag actgtacatg a 201
<210> 1106
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1106
ccaagctgtc tgtccttggg tcatgacttg gccaccctaa cccttggttt cctcacctgc 60
ataaagaaaa tgatgattga tctccctcca caggcttggg ntgagttgga atgtggtcaa 120
agttaaggtt tttatggaat gtctggtgta tttttcatct caattaacat tggctgccat 180
gctcctcatt gccacttcaa a 201
<210> 1107
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1107
gtggcttctg tcctgagttc tctcttttga attactcact ttggggcaga caagctgcca 60
tatcatgagg acactcaggt ggtctatgga gaagctcacc nggaggaaaa gaagttttca 120
gtcaacagcc agcaaggaac taaagccttc caacaacccc atgagtgggt ttagaagcaa 180
attctactag ttaagcctga g 201
<210> 1108
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1108
ggcatagtgt gcagggcccc cgaggttgcc atttgcccca gtgaggggac ttggaggtgc 60
tgcaagtcct agtgcctcag cagaagcctg gggtccttaa ngatggggga aacttagaaa 120
ccagattcaa aaggtgagag ccaatgtctg tagcagtgat accaacacat caaaccatgt 180
ggacacctca ttggttccac t 201
<210> 1109
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1109
agatctgagg ctagttgagg gaagatggtg agagctagac ttcatagaat atgcagattt 60
tcccaaaagc cagaatcact agggaagaaa tgacatcaac ntcccataaa cgcttccaga 120
gatttttcaa aataatgagt acttcgtaac tcattttata aggtcagcat aatgttgata 180
tcaaaacctg ataagggaca t 201
<210> 1110
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1110
aagagaaaag aaagagcact gcggcccctc ttcctttcac cttgcctccc ttttcctcat 60
cactgcccaa caccacattg cacatattct ttgtgaatcc nttcattgtc tgcctaagac 120
agaaacgtaa gctccatgag gagagggact tgcctctgtt ttgttcactg ctctgtcttc 180
ggcgcccagt acagagtaga g 201
<210> 1111
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1111
taaacacaca ggaagcattg tcagatataa aatggtgttt ggctttcttt ggtctaaaaa 60
ctaaaaaata ggtgctaaag gaaatttctc agtaagaagg naccgaggac tataaagtcc 120
actgctgatg tccccacatt taaaacaaaa ggtcaatttc ttagaaatta tatactttat 180
cttccacttt cctttccctc a 201
<210> 1112
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1112
agaatgattg caaacaacac tcaccaatca tttgtctcca caagaagacc ctcttagtca 60
ttccttactg ttcctattca ttaattcctt tgagaagggc nattgcttgt gagctttggt 120
tgaaaagctc agcatttttc ctgagaggaa ttctacgtta ccccattagc tggagcaaag 180
tggaagtgag gtcatcctgg a 201
<210> 1113
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1113
actctttagt acattactgt attagcccat tttcatactg ctataacaaa ctacctgaaa 60
ctgggtaatt tataaataga agaggtttaa ttgtctcacc nttacacatg gctagggaaa 120
cctcagaaaa cttataatca tggtggaagg caatggagaa acaagcactt tcttcacaag 180
gcagcaggag agatgaggga a 201
<210> 1114
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1114
ttcattacag cttttggaac ctttgttttc ttctttttct tttttgtgat tatatttaaa 60
taattttatt gtcaaatttt caattttgtt tacctttcct nagctgtttt atgggttggc 120
catttaagta aatttttcac tgctattacc ttttcctttc tattatttta atttaaatct 180
ttgttctagt tttcatctct g 201
<210> 1115
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1115
tgattgattc tgcttcacct agattgctac ctttctgcca gaatccatta cggtatcaga 60
catggcagca cactaactat catagggtac acattaaaaa ngattagaga cgctatcatt 120
gcatgcgaaa tttgtcactc ctactaaaag ttgagatttt gtattataat gagggaagtc 180
atattgcatg tttacccttc a 201
<210> 1116
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1116
ttctaaaaag cagctgctag atacatccct gtgaattttt aagggttgac aaaaattagt 60
cctcacctcc aaatgctcca aagagcctat gcaaagagca naacagaaat tcagaaattc 120
agggagggtc attcagattt agaattaccg ggtcttagaa atactttgac ttttcgtttc 180
ttcatggggt tgggtagagg t 201
<210> 1117
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1117
gagcatatat attttctgta aatgagcata caattaacaa gtataactgc atattgtctt 60
tattaactgc aagcatttat taagtgtctt ctgtgtgcaa naaatggggc aatactttgg 120
aatactaaga atgaaaaaac aacaaacaaa tgaatgaaaa actcagttga tattaagtaa 180
tttaatggcc aatgccctca g 201
<210> 1118
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1118
atgcaagtaa atctaaacaa gtcttgattg ttaaaaacca ttaacattaa tatctattgg 60
gcttataata tacagagaaa tttaaaaaaa tcatgtaaaa ngtaggaggg gctaggtaga 120
gttagagtga cctaaagtct agtgttctct gggaagtggt gaaagaaata atttgatctt 180
attatagtaa gccaaggatg c 201
<210> 1119
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1119
cagcccagag caagtttctc caaaacatct aacaattttg gaagtacctc attcttagta 60
ctaaatctct ttggttcaca atagtcacat tgttttctgt natctgcagt tgaacattga 120
ctaacacaca catacttgat aatttttctc ttcttgtgac ttgttgcttc accacaacat 180
ttttccttga gtgtttactt t 201
<210> 1120
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1120
acaagttttg acatatgtgc ttacccagga aaccgccacc tcagtcaaga taatgaacat 60
ttccttcacc ccgaaagttt catagttgcc ccctttgtaa nacctccttc tttttgcccc 120
atccccagtc tgctttctgt gactatagat tactctgcgg tttctaggat tttatgaaaa 180
tgaaatcatc ttttcttgtc t 201
<210> 1121
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1121
ttgatcatca gtaggctatt agtagttttt agtgagtcaa aagttacagg caggggaaga 60
agcagagcaa ggtagtggaa tagaagcctc cagcactcac ncacctgaag gaataccaaa 120
ttgaacaact atccacacga aaaagcacct acataagaac aaaaaaatca ggtaacagta 180
cctggtttta acatattaag g 201
<210> 1122
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1122
ttaaatctgt acctgttacg cctgtgtatc tccttgccat ttctatgttc tgatttgtat 60
tttggtgcca gatttctctg aggactttct tattttccct nttatcagca tgtacctagc 120
tatattctga ggggttaact gcagaatgaa tgattactag gcatcttaat ggacgtttca 180
ttttgcctga gtacctcctc t 201
<210> 1123
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1123
aagatggagg cagatatcag agtgatgaag ccacaagcca agtaatgcca ggcagtgcca 60
agcagctacc caaaagttgg aagaaacaaa gaaaagaacc nagatactct ggaggaaatg 120
taatgctgct gagacattga tttcagattt ctggctttta taacttggga gaatacattt 180
ctgtgggttt ttttcttgtt g 201
<210> 1124
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1124
ttagatttta ggcacttaaa agctgatttt atctatcagt atcgagtatc catgcaatac 60
caaaaagtct ttatgccctt cacatagatt agctcacaat ngccctatga ataaagaact 120
attaccccca ttttatatat aagaatgctg aaaaacaaag aggtacaaca tacttgccaa 180
ggacacacag cagctagata t 201
<210> 1125
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1125
aaaataactg agaaagtcaa atagaatata tatgtgtgtg tgtgtgtgtg tgtgtgtgtg 60
tgtatgtata cacatacata tataagtctg tgtgtaggca ntgggaaatt gtgtaggtaa 120
ccaaaatgtg agggtgaaga tcccaggaaa aaatgcaggt cattaagata agctcaactt 180
ctccatactt ctcttcctct t 201
<210> 1126
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1126
tatgaagcag tagttttaaa ctctgcctat attttagaat cacaggggta aaggaatgtg 60
agaaaggctt taaaaaggaa tttcaggatc ccagcctcgg ngattatgat ttcactggtc 120
taattagagc ctaagattta ggatttttat ttggttttgt cttaatttat caaagtattt 180
ctaatatgca gcaaggtttg a 201
<210> 1127
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1127
tgctgtgcag aagcttttta gtttaatata gtcccacttg tttatttttt gttttgttgc 60
ctacttctga tgtcttggtt atgaattctt tgcctagacc natatccaga agagttttct 120
ctagggtttc ttccggtatt tttattgttt ccagtcttac atgtaagtct ttaatccatc 180
ttgagttgat tttgtatatg g 201
<210> 1128
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1128
tatgtaatag cacttatttc tcaaaacaat gcagcctaat catgagaaca acagcagaca 60
aatcccaatt gggaacatta cgcaaggtat ctgacctata ntcctcaata ctatcatcgt 120
cagaaacagg gaaagtccta ggaactgtca cagtggagga aagcctaagg aagcatgaaa 180
actaaattta atccagtatt g 201
<210> 1129
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1129
atagccacag agaagaaaga gagtgaaacg gtttggctgt atctccaccc aaatctcacc 60
ttgagttata ataatcccca catgtcaatg tgggataatg ntaattgaat catggggatg 120
gttcccccat actgttctcg tgatggtgaa taagtctcat gaggtctaat ggttttctga 180
atgggaattc ccctacacaa g 201
<210> 1130
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 1130
ccttaatatt actcaacttt atattatttt cattttactc atttggcaaa aattcaaccc 60
ttccttgtta agacaaaact tcatcccatt tctggcctat ntgcagtcct tacagtgacc 120
tgcaatgccc tacatggtct gacctgcttt ccattgtcac caactgatat gaaaaaagct 180
aactatgtat gactaaagaa g 201
<210> 1131
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1131
tgccagcaat tacatagtcg ttgttggttt cctcaagttg tctgagccgg atggcaatca 60
tttgatgttc aattggctgc tggggagcat ttaaaaccct ngggagcata cgatacacca 120
ggggtaaacc caatagccat acagagaata atagccgagg actgaaaaac ttcctctgag 180
caaagatttc tgggagtcaa g 201
<210> 1132
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1132
accccttccc tttccatccc agagtttcca attcattagg tcactaatgg agcccaggga 60
tctgtatttt caactgcttc ccaggcaatt ccaatgatca nccaggtttc aaaaccctag 120
gcctacagca caaatgataa atgataacat ttaggttctg tctctcattt ctcctgctat 180
tggccccaca ctgaatttag t 201
<210> 1133
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1133
aatgaagtcc aatttgtcaa tgtttttctc tcatagataa ggcttttgtt attatatctg 60
aaaagtgatt ggcaaaacca tggtgaccta ggtttctcca ntgttatctt cgaggagtct 120
tatagttttg tgttttacac ttaggtctat gatccatttt aagttaattt tgtgaaagat 180
ataagatcta tttttttttc t 201
<210> 1134
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1134
cagaaataat agtagtgagc accacatttg gtgatcaggt agagtactag gtcttatgca 60
gtatgtgcca cagttgtcca catcattgac ttttcacaat nagtagtaat acagtaggaa 120
ctagcagtat ccctgtttta cagatgtgga cacagaggct cagaacattt aagtaacttg 180
tcaaagaaca aaaagtgagg a 201
<210> 1135
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1135
ctctcccgct ctaatgcaag attcgcaaag ccaggactgt atctgcttgt ttgctgctct 60
atctcccatg cctggcacac accaaaactc aataggtagt nattgaatca atgaataaat 120
gattttaata aataaatgag taaaagacgc cagagtgaag tcccagccct tgggagcaga 180
aggtaagaaa ggtaaaagca g 201
<210> 1136
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1136
gcctcacaac tactctgtgt gtaaagaatg acaattgctc cccttttaaa gatgaggaca 60
ctgagggtta aaaaagctag ggaacttttg ttggtttgca nagctagaaa gaggccttcc 120
ctgaccccct tgaagaggta acctgcggtt ccctcagttg ctagccacgt tgctctattt 180
tcttaacatc accaatcaca g 201
<210> 1137
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1137
acttgggggg aagggaggga gggggatgaa ggataaaagg ctacacatgg ggaaagtgta 60
cactgctggg gtgacgggtg caccaaaatc tcagaaatca ngactaaaga ggttattcat 120
gtaacaaaaa accacctgta ccccaaaact attaaaaaat gtggacacta gaaaattaaa 180
agttacatat attgcttgca t 201
<210> 1138
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1138
tttttgtttg tttgtttgtt tagcattttg gacatatcat cccattctct cctggtctgt 60
aagagttctg tcaagaaatc ctgttagtct gatgggaatc ncctgattca tggcttgata 120
ctttttccgt ttttggaagt ctctctttgt ctttgacttt tgacagttta agtataatgt 180
gccctgaaga agaccttttg g 201
<210> 1139
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1139
gatagcttaa aacaaatagc actatgatgc ctaccttctc acagtttata gcctaagtga 60
gcaggacctt tgtctgattc atttttgttt tgttattaga ntaatgcctg gcatatagta 120
aatgtttcat aaattattgt cattatatat tcatcgacta ttttttgagc accattttgt 180
gtctatcctt gggttggata a 201
<210> 1140
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1140
aaatttccca ttctttttgg gttgattttt gtatacagtg agaaataagg gtctatatta 60
ttcttcttca tgtttaagca ttttaaagcc ctccatggac ntcttttttc cccgatattt 120
tgttgtgagt ttttggccaa acttttgttt gtctcaattg atatatcata cagctgcatt 180
ttaaacaatt gccactgatt g 201
<210> 1141
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1141
cttccagtaa tgaagccagt caattaagac ctccttattc cacagtcaaa tcaccagggt 60
catcaaataa aattaaaaat aatccaaagg acagcaactt naaggattag aggaacatca 120
gctcacaaag atgagaaaga accagtgcaa gaactctaac aactcaaaaa ccccaagtgt 180
cttcttttcc ccaaatgacc a 201
<210> 1142
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1142
aaaatcttca cagaagccag tggtggtggg ggaagaaaca tctcatatat agaggattaa 60
agataaaaat aatatcaaac ttattcgcaa aaagtatgta ngcaaagaga gactagtgca 120
ttatttaaaa aagtgttgat agaacaaaac cactggccta gaattctgta ctatgcaaaa 180
ttatctatca aagtggaagg a 201
<210> 1143
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1143
tcttttcaga aggaagggag aaagccacca tacctcccct tcaggaaatt catcccagtt 60
acactcttga ccccatgttc cagctactca gattagacaa ncacctcttt atctgcttca 120
tgtagacagg gatggtgact ctacgtcttg tgcaagccaa gcctgaatca agggcgctcc 180
tactgtgggg atgcatcctg c 201
<210> 1144
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1144
gacttttcac caggacccaa agcaagctgc gtcatctggc tttcttctac ctttccaact 60
gtcactctat cactctcctg gctcactggg ctcaagccaa nctatgtctt ccttctattc 120
ctcaaacaag tcaagccctt ttacacctct tggcctttgt gcttacatcc ctttgcctgg 180
catgcccttt cttatagtct t 201
<210> 1145
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1145
gctgttagct gctctatctg taggaaccct gcattatggt aatgacatta ttataagaga 60
gttggtgccc agatgagaaa atcataatta ctagtggagc naagcatggt ttaatgagct 120
ccaccttgta gcaaaggtct ggagtctgta atgcaaaacc aagaatgagg tcttgaggga 180
aatcatttat gttataaaca a 201
<210> 1146
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1146
ctgccagggt aaccaccgtt ctgacgtgca acagtgtgga ttagttttgc ctgtttttac 60
catttaaatc tggagtcata cagtgtgcag ttgtgtgtct nttttatgca atgtttgtga 120
gagttatcaa tattgcaagt tcttgtcgat attttcattg ctgtatagta ttctgttaca 180
tacaatgtga ctataacact g 201
<210> 1147
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1147
agcaacctaa caacgaaggg taatgcggct ttcagttaaa ggtaatctac ccagtgaaat 60
atagtgaatc cattaaaatg aggactatga agactgcaca ncaacacaaa taaagcaaca 120
tagaacagta cctgtgagct gtgattgcaa gtgagaaaaa gtatgctggg ggaaatatac 180
cccgggggaa tatgttaaga t 201
<210> 1148
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1148
ataaaaaacc aaattaaaag cctttctgtc actgttagat cggtcatggt gcctcccttg 60
tagggaatag tgtcagatct ttaatttgta aacagaagat nttgaaggtg ttctgtctcc 120
tcagaatatt cttgagtatt atgttacttg aatattatgt tactttagta ttaatgtgaa 180
gtctctggat cattaggctt c 201
<210> 1149
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1149
tatgtctgca gctcgatttt acaggcttct tttgttagaa aagaaatgat ttggggggct 60
gcttttcatt aaaaggaaaa ccttcctaag gacttcctta ncctcattgt ctgcctaaat 120
aatttctttt taactccttt atcatttaac cctctggagt ggtaactctg ctattagggg 180
gttttggacg atgactcttt c 201
<210> 1150
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1150
ttaaacacaa gttccaattt caaaccatgg ctttgtgaat gcataaagct gaatgctttc 60
agaataatcc aggtcactcc ttgaatgctt tgtggcttag naattttttc tatcagatac 120
cctgaatcat ctctctcaag ttcaaagttc cacagatctc tggggcaggg aaaaaatgtc 180
tacagtctct ttgctaaagc a 201
<210> 1151
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1151
ttcaactgga ccacagtatt ggtggtagat ttagaagaaa tgaatagatt ccagacagac 60
atttagcaag taaaagaaag gagtggcaga caaattttag natgatgtag gaggatggca 120
tcaataatta tttttagaat tctggatttt cagctttcaa tatctgtcaa atagtccacc 180
attaaaatgt acacaacagt a 201
<210> 1152
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1152
gcatgtattg tagtagctgc ggtaaggttg tagcacaata cgttatacat gtgtttgtgg 60
tggtgcatat gtaaacaaac ctactgagct gccagtcata naaaaggtta gcgcatataa 120
ttatgtataa aacataatac tggataatga taataagtga ctatgttact ggcttatgta 180
tttactatgc tttacttttt a 201
<210> 1153
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1153
ctcttccatt aaaatgaggg cactaattgg gaagaaatgg gatccggaaa agtggaatgg 60
aaacatatga aaagatcttg ataaatctgg ggaccttcaa ncataaaatt ctgtggacct 120
cctttagtag cagaagtagc ccttccattc tgcctaagga gctcagccgt cattagccta 180
aagatctgta atagcctccc t 201
<210> 1154
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1154
tttattttaa ggctcttgac tcttacagtg agtggtcagc cattccagga ctcagctatc 60
catgattata aaacccatta gtcgtaaaat gcattgctaa naaatattta cacatttata 120
tttgaaatac agcatttatg gctcaactta agctattgca ttgtaattaa tctgtattaa 180
tctttttata ttaaaggggt a 201
<210> 1155
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1155
aactagatgt ggttatttat catttgaagt actctattca ggaaagcaca ttcaaagtgt 60
gggaggttag catttaaaac tctattcaga aatccacttt ncagaggctg ctactaccag 120
ctatttatct cagatgaata tcagggttgg ggttataaat ttgcttaatg gtcatatatg 180
tcatcatttt caagcaattc t 201
<210> 1156
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1156
gaccttccaa tggcttctta aaatgatatc caaatacctt gccacagcct accagagcct 60
agaggagacc tgccggtttc tccaattctg tctttcaccc nctccccatt gttcatcatg 120
ctttacccac actgtctcta tccctattcc ttaaacacac caagtcctct cctgcctttg 180
tacttgatgt gtcttctgtc t 201
<210> 1157
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1157
gcaactacag aagacaacca actacaatag aggtttacga aggatgctgg tattcccttc 60
atgagaattt ttcataatgc cttggtaaag acagttttct ncaaactccc tgagaggtag 120
gtctattcca acattcctac tgtcctgtgt attctaattt ctttctctgt tttatactag 180
agaagttctg gtctctcagt c 201
<210> 1158
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1158
tgctattaca agtacttacc cctgataggc cattcattga actgtttact tattcattaa 60
atactaagcg tctactacat accatgcact gtactaggtg ntgagaatat gaaagaaaac 120
aaaacaaaaa acaaatgaaa atctctgtct acattttaca ttctggtagg ggagatagaa 180
aatgagcaaa cgaataagta a 201
<210> 1159
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1159
accaatcaga atggctatta ctaaaaagtc aaaaaaataa cagttgctga caaggttgca 60
gggaaaaggg aacacttata cactgttggt ggaagtatga ngtagttcaa ccattgtgga 120
aagcagtgtg gcaatttctc aaagacctaa aaacagaaat agcatttgac ccattttggg 180
gtatgtaccc ccaaaataga a 201
<210> 1160
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1160
tgtgaccaca tcactaactt ctgcttctgt gatcacattt tcttctgatt ctgaccttcc 60
tgccttgctc ttataaaagc ccttgtgatt actttaggct natccaaaat gatccaagat 120
aatctctcta tctgaagatc cttaacttaa tcacatctgt aaagtcccct tttctgtgta 180
aggtaaggta gtcacaggtt c 201
<210> 1161
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1161
aactacccac tgggtattat gctgattacg tgggtgacaa aattatcttt acacccatgc 60
aacaaaactg cacatgtgct ccttgaacct aaaataaaag ntggaaaaaa cccaaattat 120
gccagctcta cataaaattt tccagaaaat ctcatatatt gaattatttg tcattattta 180
tggaatcaat attattccaa c 201
<210> 1162
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1162
ttcacatagc aactataaag tgaggatatg aatttttgtt gttggaggtg gtgtgttaaa 60
gtatttgaat taatgaccaa cacttttgaa ttgagacaac naacgtattt aaaaatgctc 120
aacatcacta atgatcaggg aaatgcaaat caaaactaca attgtaatac caccttattc 180
ccataagaat ggccataatc a 201
<210> 1163
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1163
gccaaaaaat ccttttgata aaagtcaata tccctttgta ataaaggccc ttatcaaaat 60
gagtatagga gaaacgtacc ttaaaataat aaagaccaca ngacaaccca taactaacat 120
tgtactgaac gcagaaaatt gaaggctttt tctctgagga cttgagaaag acaaggatgc 180
ccacgtttat tcaatataaa c 201
<210> 1164
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1164
agaatgtttc tgtctatttt ctatgtgaag atatttccct ttgcactaga ggccgcaaag 60
cgctccaaat acccacatgc agattcttaa aaagcatgta ncaaaactgc tcaaggaaag 120
gaaaagttca actctgtgag ttgaacgcac acatcacaaa gaagttttca gaatgcttct 180
gtctagtttt tatttgaaga t 201
<210> 1165
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1165
cactgatagc aagagtctgt atttccggac ctctattcct ccagcatgtc tgatagtttg 60
ataagcaaga attaatactg tttgtattaa ttctccttcc ncttgaaata ctagagtgat 120
caaatactaa ttgctaatgc acttatcttc tactaataaa taagctcatc tgctagaagg 180
gtatttgagg gacatcttta c 201
<210> 1166
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1166
tgtcatcatc aaatagagac aattttactt cttactttct tattaggatg catcttattt 60
ctctctcttg cctaatttct ccggctaaga cttctagtag natggtgaaa agaattggcg 120
agagagagca ttcttgtttt gtttctgatg gaaaaatatt cagcttttca ctattgaaaa 180
tgaaattagt tatgagtttg t 201
<210> 1167
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1167
attgtaatat cttcttgttg gattgattca tttatcatta tataatgatc ttctttgtct 60
tttttttttc ctgttgttgc ttttaagtct gtttcatcag naataagaat agctaccctg 120
catgcttttg gtttccattt gcatgaaata tctttttcca ccccttcacc atgagttcac 180
ataaatcctt acatgctatg c 201
<210> 1168
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1168
tatcatttaa agggaccaca ctcttccctt cccagcactc ccatatcact aataaacatc 60
tttcaatgtt acccgagatg atattaatga agtgactggt ngtggacccc tagagagctt 120
caggatatgg aatggttgcc agaggcacca atcatgtgat tagagggtta aaattttctc 180
caccccttta ccaggagaag a 201
<210> 1169
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1169
ggtcatactg cccaaagtaa tttataggtt caatgctatt cccattaagc taccattgac 60
tttcttcaca gaattagaaa aaactatttc aaatttcaga nggaaccaaa aaagagccca 120
catagccaag acaatcctaa gcaaaaacaa acaaacaaac aaacaaaaaa acaaagctgg 180
aggcatcatg ctacctgact t 201
<210> 1170
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1170
aagccagaca agtatattac ataaaaatta catgttatta gccctgatga acataaattc 60
aacaaaactc aacaaaatac tgcaaaccaa atttaaaagc ntatttaaaa aatcattcat 120
caaaattaat atttgcccct gaatgcaagg atggttcaac atatacaaat tagcaagtgt 180
gatacattaa attagtagta t 201
<210> 1171
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1171
ctggagagag tgctgctccc attctcttaa ctagaaaagt catgggaaat tataaaaacc 60
atatattttc ttgaacctat gagatagctg aggttacagg ncaaccagct aggctgaact 120
ctaaagaaaa gcagaaactg ccaaggagaa atgtggaaac atgcactaag ttacctagga 180
cagagcaaga gacaaataca t 201
<210> 1172
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 1172
ctggagaaac tggattgtgc tgatcttttc ccagctctgt gttgaatgac ttgatgttgg 60
tatttagaaa ctggtcatgc tgggagaatt tacaccacag naaagaataa atgctacaaa 120
tcaaagctgt tctttggagg agcagccagt cagtatttac cagaacagca cttgtcgtat 180
tgtcacttca accagtaaac t 201
<210> 1173
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1173
atagccatac ttgttgaatg atggagaatt tgctcaggcg cctagcttgc agaacttgct 60
ggaatcttgt tacagagttc tgtgaaagct attcactaag nggtgccttt cactacaaaa 120
caatccaagt ggaagctgct ggccactggc tgtggctgcc tggcatacac tgaaggtact 180
ggatgctgag gaagctgccc a 201
<210> 1174
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1174
aatttttcag caagcacaca aacatcacac aaacatccct ttgttttcct ctacctgttg 60
agacatggat tttttccctc aaaggtataa tcttgttcca ngtctctaag tatcaacaag 120
ttcctgcttt atcctctgaa tattgtgccc tccctcaacc tttttttcta aatatctttt 180
aattatcaaa taaaatttat a 201
<210> 1175
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1175
gtcactgagg atctcatctg ttcccctgac tttacacaca atctacaatc aacccagata 60
tttccttaca gttccagact tacaaattga attgcatgct ngacatctat actcagaaat 120
ttctcaagaa tctcaaaatc cccatccccc aaactgaatt tgaaactttc cattctcaaa 180
cccatttctt ctctagcagt c 201
<210> 1176
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1176
tgctcctgct ggcgccttaa agcacccaat cagatcccgc attcactcac tcacatgctc 60
cctcctgcaa gaagttgagc ccagtaagcc aagtaaacag ngcacccccg ttgcaagtct 120
gacaaagggg tcaagaaaaa tccttcatca attataatgg attatagtcc tgtaattaca 180
ttatgttata tagtatatgc t 201
<210> 1177
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1177
attctgagat ttagagcttc catttgtgtt atgcctcaaa gagagtatag acgtgttttt 60
gtttttctct tgcaactctt tttaacagta atctattgtc ncttgttatt tgtcacttgt 120
tggcttatag taagtggtgt gatcactgtt tttctgacta cgtttcagtc ttaggcatgc 180
attgtatccc tgagtctatg a 201
<210> 1178
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1178
gacttctttc tttttttttt aacacttgga tatttatttt atgatttaat ttgtaattca 60
atacaattta atgtattttt tggtcaaatt aatccaggtt nggtcattag catatttttt 120
acttagcttc gttgtctctc ttttttattt tattttatca ttattatact ttaagtttta 180
gggtacatgt gcacaatgtg c 201
<210> 1179
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1179
actaagtctc ctggttgaat agcagggaga cttattcttt cctttgtggg agagggcaat 60
atttggtttc catatgcttg gagggctttt tgaacctggc ntaattttac atggctaaaa 120
gtgaaagtaa aagacattta ctctcaagat cttttgctat tatttattgg tgaattgcaa 180
agttaaaata attcaaagtt a 201
<210> 1180
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1180
cttccatctt ccctttggtg ttaatataat tctaaaatat cttgcctctt gagttcttcc 60
aaggcctagc atttgtctac ctgaactttt ttttctagct nctgtccccc attctgcctc 120
tccttctcca gctcagacta catggaattt ttttttaatt cttctaaagc accagattct 180
cattcacctc tctggcctct c 201
<210> 1181
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1181
gaaaaccaga tacagaagtt catgctgctt agcttactaa cagtccaacc taggtcaaga 60
aatgttttct gtatggtacc tgagcatgtc aatgatccta nacatacaga aatgtttata 120
acaagtcata ggtggttcca acacttcaaa aggcatcaca tcataatttt caaaatgtgg 180
aggtcagcag tgaggcagca a 201
<210> 1182
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1182
ttgagcaggt aacatatgtc acatattgta ccaagtattt cgtatcactt caaatgaaac 60
tgtcatctac cctgttcaag ccagaaacct tggtaccatt ngttagacca gactctagat 120
catccaacaa gtctaaagta caacccacta tttcaatttt atttccaaaa catatttcaa 180
actcatcctt tttttttcag a 201
<210> 1183
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1183
tatctttcaa ggatgaaaat aaaataaaga ttaaataaaa taaataaaaa ctgagtgtat 60
aatcaataga cctcattaag ggattttaaa aaaatctgtt ntgggaagaa aaattataat 120
acaattgatt cttgttactc actgtagtta ggttccatga agttgccatg aaaactgaat 180
tagcaaatac tgaatcatgt c 201
<210> 1184
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 1184
ttaaatataa ttctactgtt gatgaacatt ttaaatgttt tttattttaa aacatttttg 60
atttttcaca attgtacgtt gttactaaca acatcattat naaatctttt cccacctctc 120
tgtaagaggt ttttcaatgc aatttcatca ggaattggaa tataggtcat agagcataaa 180
gtaacttctg ctttactgta t 201
<210> 1185
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1185
aatatcaaga agcctccctg ggctgcatgt ggctcatggg ttggacaagc tcgatttaaa 60
gcattctttc aggtacaagc atgatttgag gagctttagc naaattatgt ctgccccaaa 120
tatctcaccc aatgtcccta aatatgacct taaactctaa catttttaaa tattagttca 180
ttgctacata tttgcatatt c 201
<210> 1186
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1186
aatttattga actttgccag aatgctcttc aagaactcac gaagtataat tactctcaaa 60
ctgatctccc ctgatgcatt gggatctagc aacactagcc nccttgcttt ttctcacaca 120
ctccaggcat cctccccttt aagatttgtg tactagctat tctctctatt tcaagtgctc 180
tcccccaaga atctccacag c 201
<210> 1187
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1187
ttttcccatc cagacaccac tttaagtgct agaaatgcag ttctgaataa aatagacaag 60
gcctctcttt tcttggaaca cacattctgg tggtataagt ngaggacatg aaaagaatac 120
aatgacaaaa taggttttaa agtgattgaa tgcaagtagg gcttttatat ttcataaagg 180
gctattaaaa taggtttctc t 201
<210> 1188
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1188
tacagcacta tacagctttc ataactcatt tgatccacat aaaaaccttg tacgatctga 60
agatcaaata ggtaaaataa ctcacccaag gtcaccctgc naatgaatag aaaaattgga 120
attcaattaa gagaactaga gcaagcttcc tttcactgca ccgtagctgc cttgcacatt 180
cactgtatcg ttgagttaga g 201
<210> 1189
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1189
gaaccacatt tgaggctgcc agttgtttga gtttttgtta gtctaccatg atttgccaaa 60
tgcaaccgtt ttttgtagga gccaaacaaa agcaactgaa ntgggtatat gacgaggact 120
ctcatgtcta tatcttttag gtttttgttg gtggcactaa tctcttcagt tattcccggg 180
atacaatatt gttcctgttt c 201
<210> 1190
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1190
gcatgccttt gtactttctt tcctctttgc gggacaccag aaagctctaa atgctggaaa 60
caaatgtctc tatcacacaa cctacagaat aactggtgtg ngagtagaga agtttagctt 120
ccttgtgttt aactgggaaa aacattggag gataatttat tttcctgata tcctgggtgg 180
gaagaagttg aggtcggtac t 201
<210> 1191
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1191
atatttcctc ctatattggg ttgttgcagt tttccactga ctttagtcac aaggtcatat 60
gagtaataag aagaaatgta ggggattact tgcatgccag ntatgttcct ccttaccctc 120
actgtgtagc agcaacccaa tctccctttg gtagtcagga tcaattgccc caaaagatac 180
agcaatcccc ttctgccttc c 201
<210> 1192
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1192
cattgtctca ctttacttgc tattgggtga attttttggt tagaatcaat gctatatgaa 60
aaaatatgat agtaaataag ggattccctg agtctacaga naactgcttt ggcagaaaca 120
ttgtgggctg tgggcaggga agacacattc cagagtaagc atgtattcca gtgaggacaa 180
aagtttgcac atttcttgat g 201
<210> 1193
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1193
aaccaccaag cctggcctta aaatgtattt tagcaagtac atactgtgtg tcaggcatca 60
ttacaggtgt tggaccacag cagagaacaa cagaaaagtt naaagaaccc tgacaggttt 120
atagtattta cccattgata gggcttatag tatttaccca ttgttgcagg ttaggctctc 180
caaggaaatg ggctctgaga t 201
<210> 1194
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1194
tttgttttaa acaaaccttc cgggcaattc tgatgcacaa tgagtcttga gaaccatcat 60
tctaaaacaa aataatctga ctgcaaatct acagcataat ntgatagaaa caaaaagaac 120
tgcccaaaat cgaactcagt cactaattat atttttgcac taacattaaa ttattatttt 180
gaattttttc ttatattttt a 201
<210> 1195
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1195
ggacgtatta tgatgaagtt agtgtattta gcgtattcat cacctcaagc atttatcatt 60
tctaagtttt gagactattt caagtcctct tctctagcta nttggaaaca atacattatt 120
gttaattaca gtcgctctat gctgaaagca aatgttaggt cttattcctt ctatctaact 180
ctatgtttat acctgtgaac t 201
<210> 1196
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1196
atggccgcag cccagttgtc ctctgatatc tcatgggata ctagccacca gaaccaacca 60
atcaggtagc ccctgaattc ctgaccctca gaaactgtgc nacataatac atgttcattt 120
attttattag aaccactaag ttctgtggta atatatagat agcaatggat cactaacata 180
aatgtctaga gttcactagg g 201
<210> 1197
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1197
gggagggata gcatttcgag atatacctaa tgttaaatga tgagttgctg ggtgcagcac 60
accaacatgg cacatgtata catatgtaac taatctgcac nttctgtaca tgtaccctaa 120
aacttaaagt ataataaaaa aaaaaaggaa aggaaaaaaa aagaaagagg gtgacaagga 180
tgtttgtttt gcaagtatgc t 201
<210> 1198
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1198
ccttaattta tgagatattt ttaccaatca atttttttaa atgacaagaa gaaaaatggg 60
caaagaacac aaaaaggcaa tttacaaaag aaaaggtcaa nagcatgaga gaaagctaaa 120
ccacacccac agcaataatc caatcattca atatgttaaa ataataagag aaacagcacc 180
aatagtggat aagaacacaa a 201
<210> 1199
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1199
gaggtttatt tggctcacag ttcagcagac tgtacaggaa gcatggcatc agcatctaca 60
tctggtgaga gcctcaggct gtttccactc acagtggaag ntgaagagga gacagcatgt 120
gtagagatca cacagtgcaa gaggatctca cagagagaag agtgaggtgc caggctcttt 180
gtgacgacca gttctcatgg g 201
<210> 1200
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1200
tcgagctcat accaaagccg aggcttttgg tcagcctgaa cacactcagg ctgaactcag 60
gggcccgttg cccaggatgg agataaaact acctatccct ngggcttttg tgaaaattta 120
atgtgatact gccatcacta cagtgccttt cttagtatac aattgatatg aaaatcatga 180
tcagaaaata tgatctcgaa t 201
<210> 1201
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1201
caaagaagat gatcatggag atggcacatg ccagattatg gaagaccttg attactgtag 60
gaaagagtcc agcctcatcc tttttggatg atgtgtagat natactggga aaggaggcat 120
ggagaggtta gatcaagaaa gtagtaaaat tagcggagtc atttagcttg ctctgacttc 180
aacaagcaga ggattggagg g 201
<210> 1202
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1202
tttaacaggc ttgctgataa caatgttgtt gataccgatg gcagcaccta tcatttggga 60
ggtgtttcca aggtgcaaga caatctgcta attacttaac ncaggttatc tcacttaatt 120
ccttcaacat ccttatcatg attattgctc ttactgtttg aggaagctga ggttcagaga 180
ggataatcgg cttgcttaag g 201
<210> 1203
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1203
ttggtgttct agtatttttg catgcacgtt tgtcaggaat actggtttaa aatttatttt 60
cttttagtgt ccttgtctca ctttgatatc agagtaatga nggtgaggtg caatgagttt 120
agaagtattc cctcttcttc aattttctgg gagagtttga gaaggactga tattcttctt 180
ctttatatat ttggtagaat t 201
<210> 1204
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1204
aacaacagaa gtgaaggaca taatcttctg tttcttcatc ataacattca ctgtgatatc 60
actatttatt ttgaatttac tgtttaaaca cagaatttgg natagcacag ggaccagaga 120
caagagttgt actggaagca cgcatgaagc attacaagtt gttacttagt tttcaaataa 180
atgtatgtaa ctgggtccaa g 201
<210> 1205
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1205
caaaacagct agaagagagg ttttttaggc tttcaaaggt actgtatatt atgaaatacc 60
tagaagagtg ggttttgtgg cttcatcatc aacagatgat naatgcatga ggtgatgaat 120
acactagcta tcttgattat attattatac aacatatatg catatcagaa cttcaaattg 180
catcccataa atatgtacaa t 201
<210> 1206
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1206
ataaacttgg tgttataagt agcattagaa cacaggttcg acatccatat taacttgttc 60
aataaatatt tatagttttg tgtatctcct tgtgtttaag ncattatgct gggaattgtg 120
taaaatgtaa ccatcagttc tttgaaatcc aagaattata tttttctcga catcccctaa 180
aactcccaat aatttttgtc a 201
<210> 1207
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1207
ctgggtaacg ggcagaggtt ggaagagttt ggagggctca gaagaagacg ggaagatgtg 60
gaaaagtttg gaactttctg gagacttgtt gaatggttat naccaaatat ggagatatta 120
aaatttagtg ataaaagtgg gtttgtgtgt tgggaatttt gcttttgctt ttccattttt 180
aacgatgaca agtttacaat g 201
<210> 1208
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1208
gtagaggtac ggccttgata tccttggata ggatccagaa caattctctt aattaccagg 60
cagagactct tgttctcttt cctaactttc tctgaaacaa ntggagtttt tctctctgtt 120
ctgagctgcg tgaagccaga ggtggaatga tgcagcaccc ctgtggccac catcacttga 180
actacactgg gtcagatctg a 201
<210> 1209
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1209
agagtgtgaa taggagttga aatgaacaac tgattgaaaa cctttcaagg aaaatctgga 60
taatgaaata gtgttaggga ttatccacct attcctggaa ntctagaagg aacacatgca 120
tgcagaggac tttgtgcatg cccaagactg tgtacataca tcaagatgat ccgggaaggc 180
cctaatctct ctgttctagt t 201
<210> 1210
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1210
accaagtgtg ctcattggct cattgttact tggtattgta gtttccaggc cctctagtct 60
aatcaagcag ggtgatacac gtatgtaagc taacctgtat ngtatgctca tatctacaaa 120
tattcctata tgtaattgta tgtgtctatt ttaagcaaaa cctagattca tattgatgtt 180
accagctctc tgacatgaat c 201
<210> 1211
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1211
attttataat attatatatt atataagata taaataatat atatattatt ttcctgccat 60
gttagaattt tcatttttat aataacccat tgcattagag ntgatgtaat cctttggtgg 120
gtctcataat gccgtttgtt accagtttca gaaatgttat actgtttttt tctcatctgg 180
agaagatttc acttctacta t 201
<210> 1212
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1212
ttcctgagcc ttgaggagct ggctggtaat gaattctaat cttttgttgt cccttgtgcc 60
tatttgtgag taatcaatct acttcatgtc acttgttgta naggaagtgt tctgactcac 120
cagagtcaaa caggttggta accagtgaac ctgcttcaca catactttaa ttaaaaattc 180
ttcatgtaca tttcacaata a 201
<210> 1213
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1213
accacctatg catcaaaggg gacagcctga actggctcca cccacccatt acaggacaac 60
actatccaga agcctaggga ttgttcaacc cagtccacca ncagcgatac ttcaacaccg 120
ctcccaggtt ctcagttcaa gtgggcccat tcaaccttcc cctaacatcc aacagcacgt 180
gccacctgca tgtcttagaa c 201
<210> 1214
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1214
agatatttct aacatcattt gagcatctgg atcagccaca tcatacatga atagaccact 60
ggagttttca gtttcattat ccaattgtcc attgtcccct nttctgccta agctattttg 120
agttgagttt ctgtgacttg cagccaagac ttttgaaata tacaccacct actttctcca 180
gagatcaaag tgggccactc c 201
<210> 1215
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1215
cattttattc ctgagtcacc ctaaacattc catattacct ccttagaatg ctgttggatc 60
cctttagtca taattagtaa aggtgattct caattatgta ngtgagactg atttgaaatg 120
tctatttttt atatgttcct tggtatattt ttatatctga aatgcttgcc tcataaaatg 180
agttggagag tattaccctt t 201
<210> 1216
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1216
tatatatttg caaagaaatc tcaagaagaa aggcagaaag ctaacaaaaa tactacttcc 60
taagaggcat agaattttag tgggtggaga acaagcatgg naagactgtt cacctcttta 120
acattttttg tttttgatgt tttcaaatct acctaataaa attaaagaga taaatataaa 180
atattaggaa gttataagag g 201
<210> 1217
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1217
gagctctgtc caaggaagtt tacaaacctc tgtcagctag agaacattgg caggccccag 60
gggaaatctc acctggtaag tgggatccac ttaagggagc ngtctgtcca cactttcata 120
gagcagctgt gtcatgctgg gttaccactt cttcagtcat cttgggctct ctaaagctca 180
caggctggaa caattgtcac c 201
<210> 1218
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1218
ggtttttagt atattctttt cattaacttt gtaaaaagaa atacctttat ttaagttttt 60
tttttttttt cccctgcatt cctctttcct ctgcttctgg ntctctaatt atacagttac 120
tccaattact gttggctatt tttccctatg tgattgagga tctctcgttt tatcacgtta 180
catttttttc tttgggcctc a 201
<210> 1219
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1219
ccaacatgat gtcatgtgga aattttaaac ttaattacat ctacaaagac cccctcctca 60
aaataaggtc acattcacag gtacctgggg ttacaacttg nagatatctt tagtgtggag 120
tagacataag tcaactcatt atttcacata gtatgcattt atttatttgt taattctgtt 180
tccttccact agaacatcaa g 201
<210> 1220
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1220
ttacagctga aaagagagat aggcaaccat acaataatag ctggaaacat caacacccca 60
ctttcagcat taggcagttc tttcagttgg agaatcagaa nagaaacttt ggactcactc 120
tacactatag atcaaatgga tctaatacat atttacagaa tatttcttct aacacctgca 180
gaatacacat tcttctcttc a 201
<210> 1221
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1221
gtgtgtgtgt gtgtgtgtat acacatatat tttaattaac ttgtatcatt actttttttt 60
aatattctcc tctaaactgt ataggatgaa atcccagaat nctgaaagcc tggtgtagga 120
acttcgtttc ccagagaacc ttgccaaaag aattctggtt taattagagt tttctttgag 180
ctagattaga aatttaaatt t 201
<210> 1222
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1222
gtcctggagt cccagaccag gcattcctct ccagtgagga aaagtgagga ccagcacctg 60
tgtgcctgtg tggagaacag tttggccaca tttccattag ntgaatgctt tgtgctaggg 120
gtctcgacca gcccctgctc ctgtggactc tccaaagcct tgagacaata agggtgaggg 180
ctgtgagaca gcaaagatgg c 201
<210> 1223
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1223
agcagatgtt tgggttgggg ttggaagtgt ttcctggtgt tgctgttaca taatgtgatt 60
tatgctgtaa aactatcact taggtatgta tgaagaatgc nctggagttt agaagtctag 120
tgatcatacc ttgggtattc cacctataaa aatacaatat tgagaggtgt ggtggttctc 180
acctgtaatc ctaacaccag a 201
<210> 1224
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1224
cacaccatgt attagtgttt tccagagaaa caaaccaatt gtttgcgttc tgcagactag 60
agtaagctgg caggctggag acccagggaa gagttgattg ntgttgcaga ttgagtctga 120
agaccacctg gaggaagaca gaattctctc ttccttgggg atctcagtaa ttgttctctt 180
aagatcttca cctgattaga t 201
<210> 1225
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1225
aacaatgtta ttcaaggacc tgctgtatgt cattttagct ttccttctta gcctagtgtt 60
gtgttatatg taatttttac tattctctca gtacctacca nagtagttaa cttagtacat 120
atacgagtat aataaattca tgctgaataa atgaatgcat gagttaatta aagtaagttt 180
ttgctgactt agaaagtata a 201
<210> 1226
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1226
atcatataca gactttatta tgtttaggta catttcttct atgcctaatt tatttagaac 60
atcatgaaaa aatattgaat tttgtcaagt attttctctt ntaggggcaa caggctgggg 120
ctggtgatgt gggtggtaaa agaatttacc aaggtagtca taggtaaaga aaggcagatt 180
aattagtaaa actacaaaga t 201
<210> 1227
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1227
atcggggaga gcaatggtcc taagcatgag aattaactca gttataaaaa ataatcttga 60
atttactaaa tcagaatcta tcaagatgga gcccaaatga nggaaaattt taaaagattc 120
cacaagtaat tctgtgtatc attcagattt gggaaccact gatgtaaagg gcataaactc 180
ctctcacaga gcttcagaaa t 201
<210> 1228
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1228
gctctacaaa tccttaccaa ttgaagcagt agaaaacacc aaaaaaaaaa aaaaaggtaa 60
aataaattgc atgctatcat gccaagggtc agggtccagc ncaagctgag gtctgagggg 120
agtaggcaga ctggtggcag gtagctcaaa gaacacctgg ggcccgtaag caggtgaaat 180
gtggctttat tatgctgtat c 201
<210> 1229
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1229
agctgggaag ctacaggaga attttaaata gaaaatggcg tgatctgact cgcactttcg 60
aagactcact cctcctgctg attgaagaat agaccacagg naagggaggc atgaaaatct 120
aaggtcaagg ttaagtttcc ccaggacttc acagccttac tcaaatgcac tcgagtattc 180
tttttggctg ataccgttgg c 201
<210> 1230
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1230
ttcaaccttg ttttccaaga cagctcctat ttgtgcttca gtctccagct tttatacttt 60
ttttcttttt actttcccat gtcctccagc ttgacttaga natctttctg tatatatttc 120
caatgcagtc ttcactgccc tttttatagc acttaacaca ctgggttgcg attgcctgtt 180
taattgcatc aaagcatgct c 201
<210> 1231
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1231
ttggcatttc aggcccattt gtgtatcagc tggacattaa ggatattttt cctttaaaaa 60
tgctcatatg cacaatattt tgcttaagat ttaagagtga ncatagaatc tcctaaagtg 120
taattgtaca gtcaaagtca agaatttttg aattataatt ccttctttgt gcattagaac 180
ccctttcatt agcttgttcc t 201
<210> 1232
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1232
atgtccacag ttgatgtcaa aacataactg tggtacctgc ataccacgga atactacata 60
gcaacaaaaa ctggcctatt gctacatgca ataacttgaa ngaatattca attattctga 120
atgaatatag tcaataccta acacatatgt gccatatgac tccatttata ttacattgtt 180
ttaaatgaca caattttata a 201
<210> 1233
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1233
ctttttcctg gtcagattgg aggttctttg ctattacttg ccacaattgt aactatatag 60
aagtggtgca ttatttgcta atcgtctgtt ttcctgacaa naaaacgtac tggatctgct 120
tcgttcagaa actatcctta gtatataaaa gagtagctgg caattagtag cagctttaag 180
aatttttgaa ttagtgattg t 201
<210> 1234
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1234
aaaaagggaa aaccatttta aggaacaaga gtgatcctat aaacctcttt aataaattca 60
gatttaaaag aggtcaaaaa aagtatgtga aatttgggag naacgcaaga agatgggctg 120
cacatcattt caatgtcaca tgaattaaca tctgttcaac tatcatctgc gtaaatatat 180
acttagttaa ctcactgttt c 201
<210> 1235
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1235
cgtattgtga aacagtttga tcaatgttat ggtataaaat attgaactct aaagtatgat 60
agccctcaga agtatgaaaa atctgtttgt ccttactaga ngtggtagaa atgtcagaat 120
tgctgtggta aatgttagaa gaaggaattc tacggtttaa agatgtgagc atatttgagt 180
agatgtacta tgtaagacca g 201
<210> 1236
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1236
gaaattaagt aattcaaact taaagctgtt tgaactttaa attattttga gccttgagtc 60
gaatatagct atgtggcctg agtcacgtag cttgtagctg naacttctgc ctctctgatt 120
acagattaaa tcccttcctc agtcctgtcc tgtaaatgat tagaaaagac caaatagtgc 180
cagagagaag accccttaag a 201
<210> 1237
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1237
ttaactgtaa caaaaggatt gcagcagtag gcatgtgaca taagatacac ttgtcctatc 60
acatactaca ctacccagaa gtcccagtca gatagagtga ngggatggct tttacaggtg 120
taactgacag gccagcttgg aaactatacc attcaaggat gggcatgatg ctccaggact 180
cagtaaatcg atgaatataa t 201
<210> 1238
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1238
gtagagttca ggcaatataa atacaatctt acattgtagc aggtttcaat ttaatgttaa 60
caattaattt cagtgaatgt gttagtcaaa caaaatcaca ngtgtcttct catttcaagt 120
agtcttaagc aaactgactc tcaatgtagt tgaatgtaaa tggtgaaatg taaaatattc 180
tacaattatt tatgtagttt a 201
<210> 1239
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1239
gaatatattg ttgattagtt ttcaaccaac ctgatggcta cagctagatc tacggatata 60
ggtcacagta attaaaaggg cccaatcttt tcccttttta natgagacag tataaatcct 120
cacatgttga tgaattcttg ataaatccag ttttattcag agtgaatgat gcagtcagat 180
ctttctaatc tagtttttat a 201
<210> 1240
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1240
ctgcattttt gcatcagaaa tctggagaag tctgcacaag agatgtcctg gaagcctttc 60
ttatatattg attgtgccca gcaattactt cacttggcac ngcagtgaac atgaaccaca 120
ggaacacatc ccactgaact cgcctctgct taagtgggtt ccccaagtgc cactgctact 180
ccaatgccac cagataggag c 201
<210> 1241
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1241
tttaaaagaa gtaaaaattc aaatctaatg ctacacagag actacatttt tttaaatttt 60
tatatattta aggggtacaa gtgcatattt cttacatgct ngtattgtat agtggtgaag 120
tctggccttt tagtgtaccc ctcagcagaa cagtgaacat tctaccaaac aagtaatttt 180
tcaaccttca ccctcctccc a 201
<210> 1242
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1242
tggaaatggc accaaaatca caagcataaa aaagcaaaaa tagacaagtg ggattacata 60
aaactaaaaa gccttggcac atcaaagaat ataattaacc naatgcaacc tacagaatgg 120
gagaaaatat ttgcaagcca tatatctgat aaagggttaa tattgaaaat atgtaaggaa 180
ctcctacagc tcaaaagcaa t 201
<210> 1243
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1243
tgtatgtatg tatgtatgta tagacatgac tggcttagac tacagtagta gcattagcag 60
ttgtaagatt ctgaatctat ttttaaagtt gaaatttgaa ntggatgtag actgtcagaa 120
aaaaaaaaga gaaacaaaca taccaattgg aatatggctc caaggtttgt tttgcattac 180
gaaccagaaa gattgtttcc a 201
<210> 1244
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1244
aggggtatat gagtgagcaa gcacaggatc cagctactgc acacagccag gcatgctggc 60
tgtggcaggg tggtcagcta tacgtgccgt cagagacacc ngctccctga gaggctgtgg 120
ctggaccaga cataccagaa gcagcttcca ctatgcactg gggaacatgg tggcatctgg 180
aagcttgaag atgccaggaa c 201
<210> 1245
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 1245
aatagtttaa aggaaatatt tgtgtaactt caaaccatat agaagactcc cagtaattta 60
aagctcctca tatactcctt accaatcaaa atcccattaa nctcttagag gtagctacaa 120
gtgaaattta caatatggtt gacctatgaa caatgttggg gttaggggaa ccactcccca 180
tacagccaaa aatcaaagtg t 201
<210> 1246
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1246
atctttgtct ggtttcagca tcagagtaat actggccttg ttgaaaggct ttgggagtac 60
ttccttctcc tcaatttttt tgaacagtct tagtggaatt nctattagct actcttttga 120
tgtttggtag aatttagtaa taaagccatt gggttctcag cttttgtttg aggaaaacct 180
tttttttttt tcttatcttg a 201
<210> 1247
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1247
ccaaccccag tgtgtccaga aggctggaca tggaaactat tatcaagatt actctggata 60
cttaagattt aatgtcattt tccctgctga attttggact nggttggagc ttgtcacttc 120
ttccttcttt cctatttctc ccttttggaa tgggaagatt tatcctatgc ctgtgcaacc 180
attgtatttt ggaacctcac g 201
<210> 1248
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1248
ttaggtttgt gtaagtggat tctgtgacat tcacatgatg acaaaatcac ctaaagacac 60
atttttcaga aggtatcccc atcataaagt gacccatgac ngtgtaatac taactgccta 120
cataatttta aacatttcat agttatgtta aaaagtcaaa agaaagtgaa attaatttta 180
aacatatatt taacccgata t 201
<210> 1249
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1249
gtagtaaata aaatacaatt ccaagtttaa aagtacttta aaaccagtaa ttattgaaat 60
tgttattctg gtagtcattt aattaaagtc tccaagtaca nggtagaatt atccttttct 120
accactttaa agttacatgt gactatatga cgtgttttgg tcaatgaacc atgagaaaag 180
tgatgtgtac tacctctaga c 201
<210> 1250
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1250
tttatagctt caaatcatgt ttacatgctt tccaggaaca atcgaatata aatacatgtg 60
tgtatttgca tatacacatg tgcacataca cgtacacata natataagca aaatcatgtt 120
gttttaggac ccccaaatag gacgctttga atacacaaag aattttattt atctctgtag 180
tattctaatt ttctttttat g 201
<210> 1251
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1251
cggtaaatca gggatttctt cttggtttgg gtctattgct catgaactag tgtgatttat 60
ttgaggggtg ttgaagagcc ttgttgtgtc atattaccac ngttggtctt ctagttcctt 120
ctcatttggg taggctctgt cagagggaag gtctggggct gaaggctgtt gttcagattc 180
ttttgtccca caggtgttcc c 201
<210> 1252
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1252
tcaattatca taaagcccta tttactgtat gcctgattcc atccttgctc tttacaatct 60
gatttcagca tcacgccaca gactctgtta aaactgaatt natgccatgt catccttctg 120
ctcacaacca accaataact cccatctcgt tcagtgtaaa agccgagtcc tcaccgtggc 180
ctctgaggcc ctgggtgatg g 201
<210> 1253
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1253
caggtcagag gttggggtgg gctctgaggc tgagcagggt ggctggctgg gaattcaagc 60
caggtggaac cttcagctat gcttctggaa gcaactagct nagccttgtg tgtgggttgt 120
gctgtcggct ggcatctgtg gtcgggtgct acgtctggga ggaacacaga gctactgtga 180
aggtgcatgc ccttgtttct g 201
<210> 1254
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1254
aataaagaac tggtaataaa gaagttacgg agataaatta ctctaaatgg aaaataaatg 60
acacttggtg ataaggctta tgaggtctgg gactcggccc nccatgttca cagcagcatc 120
cccaccaccc agacatgcct ggctcacaat tggcacacaa taaatcctcg ttgaatattt 180
ttaataactt gtactcattt c 201
<210> 1255
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1255
tcatatgtct caacaataga aaactgttat aaatttttta ttactctcaa tttttacatt 60
tatttcattg cagacaggta aaaaacaggg gctgacaggc ntcaagtaac cagaaagact 120
gcgtgtactt ggtttgctag tcttagcact gcaaatttaa tcactttagt tataaattgt 180
attattctta tggcctctac c 201
<210> 1256
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1256
tctaatgctg gagtcctgac ctcggctacc ccagagtgtg gctgttttgg aaatagcgtc 60
tttaaagagg taactgcaag taaaacaagg tctttagggt ngacccaatg agactgatgt 120
cctttcgttt gtttgttttt ttaattttta agtttggggt acacgcgcag gtttgttact 180
taggtaaact tgcctcatgg g 201
<210> 1257
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1257
agcacgccat gtttgccagg accgcagatg gttattgtgg attaaattag ccaaagggta 60
ggatttgaga tcggagaagt agtggtggtc cagattcggg nggatcctgt ggcccacact 120
aagtgcttta cttcaatcta agtgaaaagg agagataatg gaagtttctg aaatggcaat 180
ttgacttatg ttttaaaaaa a 201
<210> 1258
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1258
cgtgaaaaaa ataaactact agatgttcct tgataaggaa agtttgctca tcccatccta 60
gtggatcaca tgttttgctt ctatcaatgc aatatgtaca ntagtaaaat atcccactta 120
tgggaagaag ccttacggag gcactttgtg catcagtcct cttactccca cctctgtgat 180
catggaagcc cgtggcgctt g 201
<210> 1259
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1259
tgacatcaac ccaactagta gcatagtttt tgaattatta gatgtgaatc aggcactatc 60
cactggacct ttcaatctcc aagagaaaca gatttgttct ntgaatgatc tggttgtaca 120
tgttttccct ttacactcct tcaactcaca gcatcctata ttttctgtct ttcattggcc 180
tcctcaattt aattataggc t 201
<210> 1260
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1260
attagcagca tgagaacaga cttatacacc aagtccccca gtttttcttc aattgttaac 60
atgttacgta actttagtac aattgttata attaatgaac naatgttgat ttagtattac 120
taaagtccat atgttattag aacttccttt gtttttacct aatgtccttc tcttattcta 180
agatcccttc tcaagttatg a 201
<210> 1261
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1261
ttatcataat tcacaatata aagagacttt aaacaaacac tgtcatttta atacttgcag 60
aaaaatcatc tgtaaaatta aacacttaat tatttggtgt nttagaaaga gaaggggact 120
ccctcaactt gataaaggca tttgtgaaaa ataaatgaaa agctaagatg tagttaatac 180
taaagacaga tggatttctg a 201
<210> 1262
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1262
actaattaat ttattgttat cacaaagtag aattccattg tatgaaaata taattttaag 60
attattggca gttattgaaa tcttatttgt ttcccttttt nggtttatta tgaataaagc 120
tgatgcaaat ttctcgtgga cacacatttt cattttttca ggaaaacggt atcttggtca 180
tgacatagaa atatttttta t 201
<210> 1263
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1263
atgaccctca taatatgatt catcctgagg caaatttctc tccatctgta aactgtaaaa 60
tgaaacaagt tacatgcttc caaactgcaa tgttgggaca ngcaaagcat agacatttcc 120
attataaaag ggagaaataa gcgagaagaa atgagtgata ggtcccaagt aattccaaaa 180
cccaagaggg caagaagcat t 201
<210> 1264
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 1264
ttctgattgt gctaatttga atcttttttc cttttttctt tgataatcta gctacctgtc 60
tatcaatctt ttttatcctt tcaaataacg taacttttgc ntttaatgat tcttcatatg 120
gattcttggg tcttaatttc attcatttct actctcattt tagccattcc tcttcttctg 180
gtagttttgg ggttatttta t 201
<210> 1265
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1265
gagagagcaa gagaactgtc cctaacttcc tcaatttata ttttagaggt gaacattttt 60
ttaaagtaaa tattttaagg aagtatttat gcagaaaagt naagcagaga aatgtcacag 120
ccaaagccag ttatatgagt gtatatctgg tattggagaa tgacatttta taaatgataa 180
tgggagaaga cctcactata a 201
<210> 1266
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1266
aacttcattc accttcttaa agtttctagt catctccact tatccccgca gaggatacct 60
tccaagactt gcagtgaatg tctgaaacca cagatagtat ngaatttgat tgctgtcaat 120
cagaacatgt ttttcatgtc ttccacccac aaacataacg ctttttccat gttaactaag 180
cattattcct gcaccgtggc t 201
<210> 1267
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1267
cagatggagg cagtgagatc ccagtgaacc agcctaagcc aatcctctac agatggcaat 60
ataaggtttt tctatttatt ccaagaacag tgggaagcca nggaattttt ctaagcagag 120
tagtgacaag atctgcattc tcagccaatc actgtgactg cagaatggag gacaaatttg 180
catgagggtg gagtgactgt g 201
<210> 1268
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1268
gaatgtttag aacgatgtaa tcaactgctt gctattttcc tgaagtctcc aaagagagtg 60
acttccaaga gtacagatgt tccttgactt atgcggctac ntcttgtaaa cccatcgtga 120
gccgaaatta tcataagtag agaatgcatt taatactcct aacctactga acaccatagc 180
ttagcctagc ctaccacaaa c 201
<210> 1269
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1269
aaagaaatgg aaggtttaac tctttgagat gaatgcatgt atcacaaagt ggttttacag 60
atagcttcat tctaattttt atcctgggtt attttcactt ntgccattgt actcagggaa 120
ttcccaattg tccattccca caatggacta aaacactgtt tccaaactgc tgaatccaaa 180
gaaagtttta acatggtgag g 201
<210> 1270
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1270
tatcccgttt ccaatgaagg ccacagagca ttccaaatat ccacctgcag attctacata 60
gcgtgtttca aaactgctct accaaatgga agtttcaact ntgtgacttg aatgcacaca 120
tcacaaagaa gtttctgaaa atgcttctgt ctagtgttta tgtgtatatg ttcccatttc 180
caatgaaggc ctcaatccgg t 201
<210> 1271
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1271
tcaaaaacga aatatcttaa cataaaaacc agacagaagc attctcagag acttctttat 60
gatgtgtaca tccagttcag aggtgaacct ttcctttgat ngagcagttt gaaaacaatt 120
ttttttatta tactttaagt tttaggatac atgtgcacat tgtgcaggtt agttacatat 180
gtatacatgt gccattcttg t 201
<210> 1272
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1272
tgcacacatc ccaaagaagt ttctcagaat gcttctgtct attttttatg tgaagacatc 60
tccatttcag caataggcct caaagcgctc caacaatcca nttgcagaaa ctacaaaaag 120
atttttttca aacagctcaa tcaatagaaa gtttcaactc tgtgagttga atggacactt 180
cacaaagaag tttccgagaa t 201
<210> 1273
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1273
ataggccaaa aacggctcca aatatccact tacagattcc ataaaaagaa agtttcaaaa 60
ctgctcaatc aaaatatatg ttcaactctg tgaatggacc ncacacatca caaagcagtt 120
tctcagaatg cttctttcta gcttttatgt gaagatattt tcttttgcac cataggtccc 180
aaaacgcacc aaatatccac t 201
<210> 1274
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1274
actcacagag ttgaatgcac acatcatgaa gaagtttttc agaatacctc tgtctagtta 60
tttgggaaga tatttccttt ttcaccgtat gaattaaacc nctcacaaat atccctctga 120
agatactaca gaaagactgt ttccaaactg ctccatcaaa agtatcgttc aattctttga 180
gatgaatgca catatcacaa a 201
<210> 1275
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1275
tgtgtcattt ggatttacca attgtagcag atggctagga tgaatccctt tacatacttc 60
cggcaccctg attttagctc agctttcgat tgacagttct ntacgcactg ccaggacccc 120
tatcaagttg ccatgatgtt tttgctttgc accacaaggc tttccctaga gccaaggaag 180
acagatcagc cgtttagagg t 201
<210> 1276
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1276
cagattaaat atagaggcag acatgagaat ccagctgaat ttacctaagc tagacattaa 60
aaagatttgc aaaaatgtaa aacaatgtca cttttctcac naatacaaat aattttttgt 120
ttttgaaaat attgtcactt ttcataaaaa tatgttatgg gtaatgtaat aggtttgtcg 180
ttgttatttg acatgaatta a 201
<210> 1277
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1277
ctgtgggatt atctaagagt gtggcctggt atttgcccag cctgccctag tgtccaccaa 60
tagcctccct tttgttctag taacactagc acctggcgag ncacatagat catgataggc 120
tgtctcacag tcaacgtttc agcttccttt aatagcaggc atgtggcagc gactgccctt 180
aagcaaaggg gccagacttt g 201
<210> 1278
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1278
agctgagctt ggtctgcttt ttctctctgc tctaacagga cagaactgag ttcaaagcct 60
cacacttact ctgctctctc tcccccagca cccagagaca ntctacatac catgctgcca 120
atgccagagg ttagggaggg gtgatattgg tgactcagaa ctgcttcttc tatctcttca 180
gtgcctcttt cagtgatata a 201
<210> 1279
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1279
aatctttgct tcttctctga aaggtgaggt ctcatttctc ttcccttgaa tgaaaaatgt 60
gcttggtgat ttgcttttaa taaataaaca gtggtggaag ngacagtatg tggcttccag 120
gcctagatca tacaaggcat tgtgtctccc ttgcactctc ttcagatcgt ccactctggg 180
aggagccagc tgtcatgttg a 201
<210> 1280
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1280
ggaactggag caaaggtgac tctttagcaa cgagactggc agcattttgc tcctgcccta 60
gagatttgtg gaactttgaa cttgagagag atcatttagg ntatctggaa atttctaagc 120
agcaaaacat ttacaaggtg acttggatgc tattaaaaag cattctgttt taaaaaggaa 180
atagagcaaa aaagttcaga a 201
<210> 1281
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1281
tgtttgtgac agtaaaaagt tggaaggtca aaaatatcta atgatgaatt gttaaattaa 60
gtttggcaca taatgagact ggaatattct gtgattacta naaactgaaa atgacatata 120
cttattgaca tactttacta gataaaaaag tctgtttaca taaaagtatg tacagtataa 180
ttccaatttt aattcccttt c 201
<210> 1282
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1282
tgttgggcta agtactgtgg ctcaggcctg tatattaatg tttatatctt tttaaaaata 60
attcaaggac ttacagacat ctctgtctct ggtcatgctc nttattctgg ctcacatggc 120
atttcaatta aatgtcatag ttttatcttt ttccccttta tattttaaca tattagtcat 180
tcttattgct gttttttata g 201
<210> 1283
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1283
tcacagatca aatctagccc accttttgtt ttacgagaat aaagccacac tcatttattg 60
ctctcttgtt tatggctgct ttcatgctat aacaccaaaa ncgaatagtt gtaatagaga 120
ccttatgacc tccaaaggct aaaatattta ctatctggta ttatgcagaa aaaaaaagtt 180
tgctgatcct tgatctagaa g 201
<210> 1284
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1284
ttgaatattt atgttccctc aaaattcata tgttgaaacc ctgactccaa tatcatggta 60
ttaggatatg ggacctttca gaggtgatta tgtcactcga nggtggggcc tgcctgaatg 120
gaatgagtgg cctcaaaaaa gaggcacaag ggggctcgtt tgtcccttct gctatccaga 180
aacacagcaa aaaaaactgc t 201
<210> 1285
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1285
agaactagct gcaaacagac tctagcaact tatagatgaa acctgaatga attttcctca 60
ttatcatgct aaagcttcca cgctgggaga agctatggct ncattaccga aacttgcgac 120
ctacctgctg gcatgtgtca ctatacttcg tatgtgctcc tgtccatgcg atgatgcacc 180
ctctcccctc tccatcacca g 201
<210> 1286
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1286
cctaagaacc agactagtga ttgttattac tcttctgggt ctagccaccc agtgaggcta 60
ccaggctcca ggttgctgct gaggaacttg tgcaaagagt nctgtgatat gacctgtatt 120
caggtctttc agcaatcgat accagcacct gttctggtat aggtggcatg ggagtgatgt 180
gagagtcctt agttgtagat g 201
<210> 1287
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1287
acaagaagtt caggggcaag gattccagag ctgcttgggc agctcaagga ggtcatcagg 60
gaccgagttt ctttccatct tcccgctctg gtatctttaa ngtgtaggtt tttgtcctca 120
tgcttattgg atcagagtca caggatggct gctgaacctg tacaaaagaa tcctgtatgt 180
tttccaggca gggaaatgca a 201
<210> 1288
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1288
atcgaatcag taacaaaaac cctaccaacc agaaaaggcc ctggaccaga tggattcata 60
gctgaattct accagatgta taaagacaag ctggtgccac ncctgctgaa actattccaa 120
aaaactgagg agaaggactc cccctaattg attctataag tgcagcatca ttctgatacc 180
aaaacctggc agagatacaa t 201
<210> 1289
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1289
atagaactga caaatggcct atctagtttt tataggattt ttatgcattt ccaagagagg 60
agaaagtaat tacaattaca aatgtgaatt aaatgctcag ngaaaaagga gggaaggaaa 120
atctcctttt tttgaaatac gaagacttaa ttttcttatt tttagtttgt atttgttctt 180
acacatacac ctgacatgga t 201
<210> 1290
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1290
ggggctctgc aatcagtagg tggtaaagcc attcaggtct ctgtccttcc cttcagggaa 60
gtgaggtctg ccaggcccca ggtgggtcca gaagtgtcat ncgggagtca gggactagag 120
tacaaaatct tagaagtata cctggtattc tattgtattg cagctcagct ggcacttaaa 180
ctacatggtg cagttcttcc c 201
<210> 1291
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1291
aaggttaacc tctgaaagaa aaagaaacag ttctttaaat ttaaatgttt ctgtctttac 60
ttttgctaaa attgtgatta atttcttaaa tttctgtttt nttcactaga atgtagtctt 120
ttagagggaa gaaatgatgt catattcatt tttgcattgt tacccttgtt taacccagca 180
atttgcaaat aatagctatt t 201
<210> 1292
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1292
atttcccttc actttgttgt gctccacaga tactgtgttt ttacaaattg aaggtttgtg 60
gcaatctcgg gtcaagcaag tccatcggtg caatatttcc natgacgtgt gcactttgtg 120
tctctgtgtc acattttggt aactctcgtg atacttcaaa catttcatta ttattatatg 180
ttgtggtgat ctgtgatcag g 201
<210> 1293
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1293
cacacaaaca acaaataatt tttaatacaa ttaagtccta aagattgaat gaggtattct 60
tattctaaaa aaaatttatt tttaactgaa attcacattt nactgggcat ccaatatctt 120
acctggcaaa tttaaatgtt actccatcct ccaaggagtt tttggcagag ctgaataaaa 180
agaaaaggac tctcttgaaa c 201
<210> 1294
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1294
caggatgaca taaagtcatg aaaggttaaa tagaaaagtg atagaagaga aaaatgagat 60
ttttacaaat gccaagttca aaggaggaaa atccactgtg nctcagcact gtgagggaaa 120
gtttcttgag ggaagtagtg caggcaaagg ccttgaagat tgggagggac atgataaact 180
cagcacctgc catcgtgtca g 201
<210> 1295
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1295
ctgtgactct acattagaga tcactgtaca ttagagacca caatatctta aattgagaaa 60
atattctccc tatagatcct gaggtaggaa aaaaactctg ntgaatgaag aatttcaatg 120
tagatgttct catttctatt ttttgtgtgt tgaaatacaa aaatatttca gataaaatac 180
tttcacaggt cctgtctttt g 201
<210> 1296
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1296
accactgtta tgggttcaat tatgttcctt aaaattcata tgttgacgtc ctaaggccca 60
gtacctcaga atgtagcctt atttggaaac agagtcattg ntgatgtaat gagtaaagtt 120
aacatgggcc attagggtgg agcctaattc aatatgactg gtgatgactg gtgtccttac 180
taaaagggga agtttggata g 201
<210> 1297
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1297
cccacagtca tcagctctgc tcattcccca tcactttaca ttttctggat aatatttttt 60
ctatttatgt gtgtattaat gaattgcttg tatcctccac ntgaatgtac aatcaataag 120
gtgtaaactc acccatcttt ttcaatattg aatcctcagt tcagtgcaca tagtagtcac 180
ttagtaaacc ttatttattg t 201
<210> 1298
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1298
tacaaatgta ttattggtag aaaaaactga ccaaaaacaa tgaacattat aaagtaaatt 60
atgtaggatg ttaagaggtg atgagtacta tagagcaaat naaagacact cacttgagca 120
aggtaaaggg aagagaatgc tggggtccag caggtcaggt tacagcctta tatattctca 180
ttgaggaaat gaaatctgag c 201
<210> 1299
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1299
ttcctcactg ctctgcagtg acacttggac ataaatcaaa tagccatgta ctgtgtagct 60
ctgcttctgt tatgcccaat cattgaatct gaatccaata nattctttag atctaactat 120
caatttgtgg aaaatacaag agagagagga gcatgttaag tgacactcca gaaaggccat 180
cagcaaaagc taagttaatg g 201
<210> 1300
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1300
caactggtcg aacatggtgg aaataacaga gcatggtttt caaaaatagg ccgtaaaaag 60
ccttgcagct tccacctggg tatcttggga tgttcccttc naacccagct gccacgccaa 120
gagaaatcca agccacatgg agaggacaca gttactggaa ttggcagcct cagctaaact 180
cctagccagc agccatgtga g 201
<210> 1301
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1301
cataggaatc cagtctcatt cttcagccat atgaatggac tattgtccag acaatatctt 60
ttgtcactca tcttcaattc cactttggca taaaccaagt ntctttgttt gcatgggtct 120
gtttctggtc tctctattct ttcacactgg tatattttcc tattcttgca cctgtacaca 180
ctttcttact tgtcatagct t 201
<210> 1302
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1302
gtgtggtaga gcagaaaaaa cagtggtcat aggcattgca atttcatgga ccaatgcttt 60
aaaaaaaaat ggtaagggct ggcaactact gtggtctgaa ngttggtatc tccctcaaat 120
gcatatgttg aaaccctaac ccccaaagtg atgctattag gagatggggc ctttgggaga 180
tgattggact gtgagggtgg a 201
<210> 1303
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1303
tttattgaga acatactata tatgagggat agggctcatt gctttaaaaa tggtatttct 60
aattctcaca acaagcctac agggtgattt gattactact nccattttac agctaagcaa 120
aataaggctc aaggtcactt gaggacctga acttgagctg ctagacccta aagaagtgta 180
ctgattattt agcaccattt g 201
<210> 1304
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1304
tgtggcccgg ttcctaacaa gccacacact ggtactagtt tgcactccat gggttaggga 60
cccctggttt aggccagaag ggccccaccc ttatgaattg nttaacacta ttgtaaaacg 120
gcttgatgag gacgtttggt cccttttacc tttccagccc ttctgccacg tgagaacaca 180
gctttcctct tctctggagg a 201
<210> 1305
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1305
acaacaatta gaatttgggt atgcagagat gggaggaaat ggggagcaga tacggactag 60
acagtccatg tggaggaaat agcttaagca ataagctcaa ntaatatacc aactaaaata 120
ataataataa caataagctt tgtatttcag aatttattgt cctaggaatt actgcacaaa 180
atcggagctg aagtatgtcc c 201
<210> 1306
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1306
ttgttagata tgacatcaca aacttgatta ccgaggacaa gaaaaaataa ttgatacaat 60
tgaattttat caaagctaaa attttttggt atttgaaaga ngctattaag agaatgaata 120
aaggtgatat ttctaccttc atcagatgaa aaggtgatca acatcattat tcattagaga 180
aatgcaagtt aaaaccatga t 201
<210> 1307
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1307
ggagcttttt tttttaaaaa aaataccatc acctgggccc cagtccaaag tgaatcaaaa 60
tctctggggg gtagcattct ggcattggta ttgttgaagc ngttctcctc tccaggtttt 120
tctaatttac agcaagattg tgaaccatcg ttctaatgag aatttaatcg accctaagag 180
aggaaaatcc acacgttgaa t 201
<210> 1308
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1308
tttaacaaaa caaaacaaaa ctaagattgg aacatgcttt gagtttgttc ttgtattagt 60
ttttccttaa gttaattgtg aacatttcca cattgttaag nactttttca gaaacataat 120
ttttaatgag gataccataa attgcttagt ccttccccca ttcttgaaca ttgtggttgt 180
tcagtatttt gctattatga a 201
<210> 1309
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1309
gtagggctct gtgtcctgga ccatgaagaa aggcaggctt gtagcttatc tgcttcctct 60
tggtcccacc agctctactc cttttgccta attaggatgc nacagctttt accagcttga 120
gtgcccctct tttttaattt ttattttttg agacagggtc ttgctctgtt gcccaggctg 180
gagtgcagtg gtgcaatctt g 201
<210> 1310
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1310
agaaaccatt ttgtgaggtg tgcatttatc tcaaagagtt aaaccttttt tttttcattc 60
agtagtttgg aaacactgag tttgtaggat cggtgaggga natttaggag tattttgtgg 120
cctgtggtga aaaagaaaat atcttcagat aaaaaacaga aagaagcttt ccgagaaact 180
gctttgtgat gtgtgcattc a 201
<210> 1311
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1311
atttctgata catttattaa aacaacctac agaatgagag aaaacatttt caaactatgc 60
ttccaagaaa agactaatat ccaaagtata taaggtattc naataatgca acaagggaaa 120
aacaacacca ttataaattt ggcaaaagga cacaaataga cacttttcaa aagaagacat 180
acaagaaccc aaaaaacata t 201
<210> 1312
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1312
gatatggttc ctaatatcca ggggagaaga ggatgatatt actccaaata tcgcagggga 60
tgtacaccct ctgtgaattt gtttctaata tccagtggta nagttgatga tagtactccc 120
aatactgtac aagatgtaaa cattttctgt gatattattc cttatattaa ggaagagaga 180
ctatcatatg acttccaata t 201
<210> 1313
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1313
atcctaggaa tgattgttat tgcttttttg tagagtaact atttatttat attcattcca 60
aataattaaa atttcactgt ttttctattc ccttctgcat nattggcatt ccagttggga 120
tttacttctt atcaacagaa agcaagtctt tattatttct tttaatttat ctctagtaat 180
aaattcagga tgtttttgtt a 201
<210> 1314
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1314
atacctaaaa ctctcctact ttgctgacgg gagtgcaaaa ctacacagcc actttggaaa 60
gcagttttgt agtgtcttgc aaaattaata tacactgaac ncgtaactca gtagtccact 120
ccaggatatt tgctggagat gaaatgaaaa tatatattta cacacacaaa tctgtactta 180
aatgtttgca gaagctttat t 201
<210> 1315
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1315
attcatgaat atgagatgat tttccatttg tttatgtcat ctataattta tttcatcaga 60
gttttgtagt tctccttgta gagctctttc acctacttgg ntgattgtat tgctaaatat 120
cttttttttt aacttattgt gaatgggatt tagttctttg tttggttccc agctttacca 180
taattgggtg tatagaaatg c 201
<210> 1316
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1316
gaaaatctgc aacatatgct tgcactctca ctcagacccc acactctgac actggaggat 60
ggcagctgta agtgaaccca tttttaagcc acctccttat ntctgtgatt tagagagact 120
tgggaatcga gaaccacttc aactcccaga gctaggtcat ttagaaacca gtatctctgg 180
tggcagtttt aaaagttggg g 201
<210> 1317
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1317
gtaatgtaca acaaagttgt tggttgacag catgtttgta aaatgttata taaatttgat 60
tatttttatt gtctccttac actgtcaaat ctgtcattct ntagacataa gttacgtaat 120
caccagtttt aggatttgac attttcttgg aaacctggaa gccacccttg tttcactgtt 180
ggtgaagact ggcttgcttc a 201
<210> 1318
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1318
cttctttaga aggaaaaacc cactagaaag ttatcttttg ctctcaaaat ctgagaaatc 60
ttacagctta cttagtaata tccacatagc ttacatgctc nttttaaaat ctaaagaggc 120
ctaacaagta ccctatccta ctggtaggag atacaaattt ggcttctttt attttactat 180
ggagaagaca tattgataca c 201
<210> 1319
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1319
actattactc tttatgcttt catagcccct ccacttatac ctgttctgat tctcaaatca 60
atatgtttat ctagacttct cctctgagcc tcatattcca nctcttttct gtttatcttc 120
acctaaaaag ggatttgagt atctcaaact caacatggtt acaactgtac tggtcataaa 180
ttacccacaa accttcccta g 201
<210> 1320
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1320
ttagaagaca atgaagcaca aataagtcaa ataccatgcc caaggtgatg tagccagtaa 60
gcagcagagt cctaattcaa actaggtggt tgtctcctga ntaatgaaag ttgattaggg 120
ctttcttttt actataaaag cattgttttt attttttctt tttatcatgg gagatgccat 180
tcattcaatg agacagtctt a 201
<210> 1321
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1321
taccactgta ttattggcac ttcttcctca gtacacaact gacggaagag gtaatactgt 60
aaggttgctt cacagatggc tcagctctgt atggggcata ngccaaaatg aagtactgct 120
gcattatgat attactcagt gaggtccttg aaatacatca gtaggtcagt tattccaaag 180
ggaagtgctt tgggtagtac a 201
<210> 1322
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1322
agcatcttat ttgctcagag agaagagaat atatgtgacc ttcaaagtgt ctatttaaag 60
ccactttaca tttatttagc aaatattaat gcaattagta ngtgctaagc atcactttaa 120
gcattttatg aatattaatg caattaatct tttaaaaacc ttgggagata ggtattattt 180
ccccctttac agttggggaa a 201
<210> 1323
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1323
gaatggcatc tcattgttta cattttatta tcaattgggc tgagagcctt tttcaagtgt 60
ttattggcca tttgctattc ctcctcagtt tccatccatc ncttgcccat tttttattga 120
gttttctttt ccttattgat ttgaaggagt tctttaagta tttttagata ctaattatct 180
attcgtttta ttgatgtaac a 201
<210> 1324
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1324
tgtttgtgtc cccgctacct ccacaaaatt catgttgaaa tcctaaccct catagcgatt 60
atattaggga tggggccttt ggggaatgat taggtcttgc ntgtggatta gggcccttaa 120
aaaaagacac aagagagttt tacttcagct ctctctgctc ttacaaccat gttataatac 180
aatgagaagt agacgatctg t 201
<210> 1325
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1325
taaatagtaa gacttgaaag ttgaaattac tccttgatcc atggtcagta taatgaatgt 60
tgtgttagca agcatggaaa caatgctaat ctctttgtac ntcaccttca gaaggcatga 120
gtgaccaggt tcattgtcaa taagcagtta tatttcaaaa ggagtctttt tttccaagta 180
gtgggtgtcc acagtgggct t 201
<210> 1326
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1326
aattgtttaa ctctataaaa taaatattac tattgcaatt tattagatga gaaagtgatt 60
ctcagattgc tgaactaatt tgtccaagat ctcacaaaaa nttattggcc agaaacaaac 120
ctatgtgtgt ctttctaagc aattgaaatg cttttgtcat gatatgcttc agcaagaaga 180
acattttcat cacaggacct t 201
<210> 1327
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1327
tattttgtct gtatttgcct gcttccaata cctatcttat atttttagac tttctgaatc 60
acgttgttct aagggtatct ttttcatata gcacatagta ngattttgct ttctgaacca 120
atcggaaaac atttttcttt acaaaggaac ttaaagttaa gcccatttga atttactaat 180
atatttgatt tgctcagttt c 201
<210> 1328
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1328
gctccccaaa gaaccacagc tcttctctcc ttctcatcac cacaacatgg cgagcagagg 60
ggcatgtttc agccctgttt gtgttacagc tttttcggtc ntgcaatttg gcaggtccca 120
agttcttgtc ctacatccag gaagaatgag gtatatggac aactggaggg taagcaaggc 180
agagaatagc ttcattgaat g 201
<210> 1329
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1329
tggtttctct gaacaggtca agtatcctgt tgtagactct cataacccct ctgtacagca 60
ccctgatagc actcatcata gtcaacattt gctttatgtt ngccccacca cccccagtaa 120
cactgctaga tccgctagga caggactgtg tattattgct gcttattctg tcaccagtgt 180
ctagtacacg gcctgccata c 201
<210> 1330
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1330
ttacagtaag gcttgtaatt agatatagaa ggtcctccaa atttgttcaa gattgttttg 60
atatttgtat ttccatataa attccaaaat gaatgtgtca ntaccctcca aaaaatgtct 120
ggaacatttt gggtattgca ttgagcctga agatgtgaaa taaacatatt agcattattg 180
aatcttatac ttcatttgca t 201
<210> 1331
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1331
ctgaaaatta gattaagaac attttattta ccatagcatt aaataatact tagaaataaa 60
gttaacaaaa gaagtgcaat aattttatta taaaaaccac naattattgt tgaaagtaat 120
taaaaaagat ataataaatt gttcaaaatc tcatgttcat ggatcagaag acttaatatt 180
gttaagatgg cagtgttttc c 201
<210> 1332
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1332
ttctctagag aaacaaaacc aataggaaat agataggtag ataagacaaa tggacagagg 60
agagacagag agagagagag agagaatttg ctatcatgga ntggctcatg taattttgga 120
ggctaggaag tcccaggatc tgctgtctgc aaactaaaga cccaggaaag ccaatggtgt 180
aattcagtct gaaggccaga g 201
<210> 1333
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1333
ctttcaagcc aaattattta aaattctaat ccagtcctta cagacaagta attaggaaat 60
cctactggct ctgagacctt cacaaatata tccagaatct nacaacactc cacctgttct 120
cccacctctc tgacccaagc cactcacctc ccacctggac tactgtggca gtttcctgtc 180
tggaccctct gcttctccct t 201
<210> 1334
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1334
cctccaatgc ttgaatgttg tgacaccact gattgacaca aacccagctc aggcctcagg 60
aagagtaggg ggagacaagc caagtcacaa tccaaattag ngcagccgct cctgcagcaa 120
ggggaacaca atgtggtctt tgactaacct ttcaatgccc tgtgtagctt gagccctgag 180
ggcggtgccg agctgacagc c 201
<210> 1335
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1335
ctactctatg acccagcaat ctcacttctg ggtatacatc caaaggaaat aaaatcagaa 60
tcttgaagag atatctgcac tctcatttaa ttgcatcatt ntttccaaca gtcatgacat 120
gggagcaacc tgaatgtcca ttgactgatg aatggatgaa aaaaatatgg gatatacatc 180
caaaaaagat tattcaggct t 201
<210> 1336
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1336
gaacacttct caatgcttag ttcaaatata aagataatag aaaactccca gggaacagaa 60
ccaggggcca cagagaacta ttgacaagat aaataaagcc naagcagaat caaagcaatg 120
gatgtcttcc attgctaagg caaggggtct atattgtttc ttcctgcgaa gatttcttat 180
ggctgcagac cacggctgct a 201
<210> 1337
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1337
acctatcatt gtgttccaat tgcctacagt atttagtaga gtaacatgct gcacaggttt 60
gtagcctagg aacaataggc tgtaccatag tctaggtatg nggtaggctt gatcatctag 120
gtttgtgcaa atacatatta tgacgttcac acaaccacaa aatgcctaat ggggcattct 180
cagaatgtat tcctgtcatt a 201
<210> 1338
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1338
agaaatccaa gaagattgga gtatactgct tagccaaggt ttccagaaac caaacaagct 60
aacatttcta tggaaataaa acaacaacaa caaaaaaaaa ncaggttaat gaatataact 120
cagtctgtgt gttcagaagg cagttagtca agaaaatgtt aagatttgag ctcaaagcat 180
attttcctag tttgcagtct g 201
<210> 1339
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1339
tggagcaacg tcagttgatt taggaattta cgaatagtta gatgtgaaga gcatagcaat 60
tgcatttgga aaatgatata acagtatcta ttaaaactaa ntatatacat aacctatgac 120
ctagcatttc ttttattttt ttatttttat tattattatt ttttgagaca gagtcttgct 180
ctgttgccag gctggagtgc a 201
<210> 1340
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or A
<400> 1340
tttttttcct aacaaaaggg tctacagtaa ctggctgaaa tagtccttat gccagaaagg 60
catattttgg agactaattc agctacacag gctgcttctt nacccaatct gtgtttcttt 120
aactagatta ctgagttcag ggtggagctc attaataagt agggcaaaca gagcattttc 180
tattcctgga ctcagcatgg a 201
<210> 1341
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1341
attaatcaag aatgggggga atgaaagtaa atcaagcttg cagcacatgc actgttaatg 60
attaggtcag ccttctctct ctgacctgct tcctcgtact ngcttggtgc ctattgcctt 120
agaatcacat agactcagtt acaagattat tgttcccctt aactgctcta tagatagcaa 180
ctcgaacatt ataacatgtt a 201
<210> 1342
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1342
tccttctaat tgaacttttg tgttttttga ccagcacgct tcccaaccct tcttcccatc 60
cccaacacct ggtaaccacc attctattct ctgcttccat nagttcaatt ttgagtccat 120
atatgtgtga gattatgtgg taactgtctt tctgtgcctg gtttatttca cttaactgta 180
aaccaaaaat aaaatttgaa g 201
<210> 1343
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1343
gagactttgt taagctggga tcctattgga gtggtgcagg cctttaatcc aatctgaccg 60
ggattcttat cagaagagac acagggagaa tgccgtgtat ngataaaggc agcgattgat 120
gtggctagaa atcaagcatt gccaggacta caggagaaac gaagagaaag gtatgaaaca 180
gattcttccc tagagacttc a 201
<210> 1344
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1344
tgcctctcct tctgccatga ttgtaaattt cctgaggctt ccccagccat gtggaactgt 60
gagtcaatta aacctctttc ctttataaat tactcagtct ngagcagttc tttataacag 120
tgtgagaaag ggctaataca ccactgcatg gcagctggca tcaattactc tcatggctac 180
tgcaggtaag taaatgcttc c 201
<210> 1345
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1345
taactctgta tgaaaagctt gattcatgga caaacaaatt aaaactaaaa aaaaagaata 60
ttgagataga attgaaattc acctctccgt tatattctaa ngatggacaa aaattgtctt 120
gatgtttgaa atgcttgaat ctcgaatttc aaatcaatcc attgactttt tttttttttt 180
taccggctgc aaagtttttt a 201
<210> 1346
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1346
ttccctggta gaaccagcag aaatgcagat gcagtttgga atggctgaga tgttatgttg 60
aaggttttct ccttatgaaa agaggatgcc tttagttcac ntttttcaaa gcatgctcac 120
agatagcacc ttatttcaaa tcacactttt gtacagtgag ctgaaagtgc ttttttctct 180
tccttttaaa aataagggag a 201
<210> 1347
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1347
agaaaagcat aatgtaatgg ttgagatgga gctataatgt ctgaacttca agtgattctc 60
ctgggctcaa gtgatcctcc atctccagcg tcctgaatag ntaccactac aggtggttgc 120
caccacaacc gtctaatttt tttaaactct tttttttttt taagagatag agtcttgctt 180
tgttgcccag gctggtcttg g 201
<210> 1348
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1348
aagacccgcc ccatgattca tttacctccc accgggtccc tcccacaaca gcggggaatt 60
atgggagcta caattcgaga cttgggcggg ggcacaggaa ngccatatca atgctatttc 120
cagatagcat gttctctttc taaaagacgg tgccaatcaa gatcctggca agaaatatat 180
ggcacattca aataggtaat t 201
<210> 1349
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1349
ttagtaagtt ctaaaaagca aaagccacaa aatcagaaag tgacaaatgg gagttaatta 60
aactaaagaa cttctgctca gcaaaagaac caagaaaaac ngttaacaga tggcctacag 120
aatgggtgaa aatatttaca aactatgcat tcaacaaagg tctaatgccc agaatctcta 180
agaaacttaa agaaatcaac a 201
<210> 1350
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or C
<400> 1350
ataaatgaac ctggaagaca ttatgctgag tgaactaagc cagtcacagt aagacaaata 60
ctgcatgatt ccacttacat aaaatattta gagcaatcaa nattgcagag acagggagct 120
gaggcaggag gatcacttga aggctgggag tttgagacca gcctgggcaa catagcatga 180
cccatctctt aaaaaaatta g 201
<210> 1351
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1351
acagagagac caattacagg gtcattgcaa taatccagaa caatgctttt gagtagtaaa 60
gggggggtga aggtagtgag aattttttta actgtgtata ngttttagaa gttgagtcaa 120
gaagattttc ttgcatggat atgtgaaaga aagagaaatc tcagaagtca aagattttgg 180
cctgagcagt aaaaaggata g 201
<210> 1352
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1352
aagttaggag tttttccgtg tgagttcaag aaagccgaaa gtgaagtgat gataacaacg 60
gactgagaaa ggtaagctag gaaaggatgc aagtgagaac ntgaagacat ggagaataag 120
atcaatgcct gaagggccag tgggattgaa aaattgttag aggagggttg cctagtgagc 180
aagaaaggta gtgggtgatg g 201
<210> 1353
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1353
tttggaaaaa ttaggaaaaa attaaaacat atatcatcct ccaaagatta ctgatatctg 60
gtgtactcat tcttgattct tgatctgtag gttagaaacg nggctgacaa attcagctgt 120
gcaagtcgtg cactgtatga tctgaggaag caccatccac ataaattgct atatgatcag 180
cactctctgg gttgtgcaca c 201
<210> 1354
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1354
gtgtgggttt ctgtgtgtga tttcataaac acatcagttt ttgtgtgttt gctatataat 60
ggaatcatat tatataactg tattgttttg tgagctattt nttttacttc atagggtaca 120
ttggcaacct tttttgtcag tacatagtgc taaataatat gtcatgcttt gttttatttt 180
attaatatta ttactattat t 201
<210> 1355
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1355
atctcagtaa gcatctccca cagttgcctg cccagtattt tatcctgtga actaataaga 60
aaggtgcctt ataagtaaag tgactgtata atttattgtc naaaccaaaa cacctttgtg 120
accgaagaag tccactctta ataatcacgc caaaacaaca cacagaaact ggaatcgtcc 180
caggagaaca agtcactcta c 201
<210> 1356
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1356
tcatctcaaa cagaaaccct gtacttttta cagaagaatc cccaccctaa tctactctca 60
gccctggtaa cttctattat gctgtatgtc tctaagaaat ngactatgct aggttcatct 120
tataattgga attatacaat atttgtcttt tttgtctggc ttacttccct tagcataata 180
ttttcaagat aaatcatgtt g 201
<210> 1357
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1357
caaagaattc ttcaactctg tgagtggaat acaaatatca caaagaagtt tcggagaatg 60
cttctctcca gtttttatat gaagatattt cctttttcac naccggcttc aaagtgcttc 120
aaatatccac ttgcagattc tacaaaaaga gtttcaaaac tgctctatgg agagaaaatt 180
tcaactctgt gagttgcaag c 201
<210> 1358
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1358
tggaactcct gagctcaagt gatccacctg cctctgcctc acaaagtgct gggattacaa 60
gcatgagcca ctgcacctgg cctggatgga ctttttaatg ncctagttaa tagaaagctg 120
caaaacgaat gcagtgtgat ttcttttttt tcttttttct tttttttgag atggagtctc 180
actctgttgc ctaggctgga g 201
<210> 1359
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1359
gcagctgtga tcccagatgt gatatgttta ctagaacaga tcaacacagc atctgacact 60
tgatatatga tactcaatat gtcaaataca ttcttttcaa nccctatcat taaggaagac 120
caaaggcagt taacttttac acagcaagga cagtaataca cataccactt gccctatgtt 180
aagttaccta ctctctgtgg t 201
<210> 1360
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1360
atctcatgta atttattgaa tactgtcctg aaaatgaaaa acagaatggt tatatgcgta 60
cttggagtac agtttctact gaatgcatac cagtgtcaca ncattgtaaa ttcaaaacat 120
ttttaggtgg aaatatggta aagtgggaac tgcgtgtatc tagcttccag ggcagtagtc 180
ttatttgtca ttatatctca a 201
<210> 1361
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1361
tatcttcctc atttgtttta tacatcgagg atgtcagtga tatccaaacc tggtaacaat 60
gccattgcaa aaaaagaaat gtgtagaaca atatgcctca naaacacagc cacaacattt 120
gttaactaaa catggcaagt aaatatagaa atatataaca aaatatagca aaattatact 180
atgacccagg taggttttaa t 201
<210> 1362
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1362
ttgaaaactc tatataaaat gatatttttg agaaaaatga aaaagacttt aacaaaagaa 60
aatatatgcc atattctggg attagaagac ttaatattgt ncagatgtca attccctcta 120
aactgatcta taaagccaat gcacttccag caaatttctg tgatgaatat tatgtgatga 180
tgtgattcca gaatttagac a 201
<210> 1363
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1363
aaaatgtctc cttttacaca tgtggaatat cctctagcat acatgcatat gcagaattgc 60
ttagtctggt atttatgcat ggatatgaat tttactagct nctaacaact tatactatag 120
caagggtagt atttgagagg tctcacttgt ccaaattctt gccaacactt gatattgcaa 180
gactatagtt tagtacaaat t 201
<210> 1364
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1364
tagggaggga tatgttgtac tctttttaag tggcagtttt tataagttat tttcaatgtg 60
gaatatgaaa ccctataaat cagctttata ctattgcatt nactttgaat aagtctattg 120
tcgatgcata taatactaaa tattggctaa gagtggaagt aataagatct ggtaagtatt 180
gctggtggca gaaaaaaaag t 201
<210> 1365
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1365
aacatgtatt atttaaaatt ctacaatatt ataggcaatt ctataatatt gtgaatgata 60
ttacggtgat catccttgta tgtatatctt tgcacacaaa ngctcagagt tttagttggc 120
tatattaagt gggatactga gtgacagtca gtagatttaa aattatgatg gatggtagta 180
cccgctaaaa taccctcaaa c 201
<210> 1366
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1366
atacatcaaa agaatgatcc aaaaacattg ataacgtatc agtagaaatt tgaagaacat 60
atgtgagaga ggattctaag ggtgttagac caaggagtgt ngactataac attgaattca 120
ttaacatgat gcacttaata aagattctga atttaatatg ctagtttgtt caggttgaaa 180
tagctcttac tgcttacttg t 201
<210> 1367
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1367
catgtttttc cccacccagc cagaagaata atttttcaaa tgcaaggcca accatatcac 60
tccccaacta taccatccag tgaattccca ttgagcacac ngtaacatcc aagcatctta 120
accaggcaca agtgactctt tataacttgt cccctctctc atccctctag tgctatccat 180
atctcagtcc taacaatatt g 201
<210> 1368
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1368
cagtgatgtt atggcatcag ggagccaggc tccttccttt cactactcca cccacctgag 60
gagctccaag atgactttgg aatgtctagg cagtccatct ntctcagggt ggaagaacag 120
gcaaatggca tgcttgggat ttgcaccctt tctattaaga agacatcttg gaagtacaac 180
atcacactga ttacatatca g 201
<210> 1369
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or G
<400> 1369
gaattaggaa atcactattt cacaatcagc aatgaatgaa tggatttaag catttttcat 60
tccagctgcg aatatcaata aaaaagacat tttatgccta ntaataaaga agacattttg 120
taagggatca tttctgagac tgatgaagtc tctggataca aattctaatt tttaggaaat 180
ataggagaca gaagaacaca t 201
<210> 1370
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1370
cctaaaactt acattttaca ggaggagatg aactatgaac aaagaaaaaa ctaagtaaga 60
tagttggtac agctgacggt attaagtgct gttgagaaaa ntaaagcaag gaaggtggtg 120
gggaatgggg agtggtactt actcctcata gaactccaag acagaaatgt gtggcgtact 180
tgttctatgt ccactttttt t 201
<210> 1371
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1371
ggcagtccca gagactccca gcaacaactt ggagatctga atggggctgg agatcattca 60
ttacacagct gcaggaatga gcagagaaac ttgactttcc ntatgcatgt aaacacagga 120
ggcttaagga aatttggatt acacttcctt ctagtcactg ggggcttagg gcaatgaaac 180
aaggatgagt cgttgcaagt c 201
<210> 1372
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1372
actgtatgat tctaaacata tgatattctg gaaaaggcaa aactatgaaa atagtaaaaa 60
tatcaatagc tgccagtgct cagggaaagg aaacaatgaa naggcaaaga acagaggact 120
tttggggcaa tggggactgt catatattat aatggcggat atatgtgatt ttacgtttgt 180
ccattttcac agaataaaca a 201
<210> 1373
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1373
agcaggaaca ggagagaaaa gtggaggtac tacacactta aacaaccaga tctctcaaga 60
actcactcgc tatcacaaag agagcaccaa gaggatggtg ntggaccatt catgagaagt 120
ctacccccat gatccaatca cctcctggca ggctccacct ccaatactga ggattgcgat 180
ttaacatgag atgtggatgg g 201
<210> 1374
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1374
tctagagcaa ggtttggaaa acttttcagt acaggatcag tttgtaacca tttttagcat 60
tgcaggccat aggtttctgt gacaactcaa tcctgccatt ntagtgcaga agcagtcagg 120
ggcatggcca tggtccagta acactttatt ctccaaaaca gagggcaggt taaatgtgac 180
ctccactgtg tccggaatgg g 201
<210> 1375
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1375
agtttccaag tccataaaaa taatgtaata tatctccctc tgagatttgt tgaaagggca 60
aaattgaaca atgttagtaa agcaactagc acagtgctgg ncagataatt cctccaataa 120
gggcatctat tttgatggag ggttgttttc ccccttgaaa atgttagtac tataaaatga 180
tctcatagtt taaatgttct a 201
<210> 1376
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1376
gtaggttaga atttttaatg acatggtaaa gaaagacctc attgagaaga tgatgcttga 60
gcacagatct gaaggaagtg aaggaacaag ctgtatagtg nctaggcaag gaacattcta 120
gacagataaa atagaaagaa caaaatcctt tacccagggg gatttgcctg cagtgtggct 180
aaagtggata cagtaagggg a 201
<210> 1377
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1377
aatccctatt gtaataccaa tgacattctt cacagaaata gaaaaaataa tcctacaatt 60
aatatggaac cacaaaagac ccaaaatgac caaagctatt nggagcaaaa agaacaaaac 120
tgaaggaatc acattacctg acttcaaatt atactgcaga gctatagtaa ctaaaacagc 180
atggtactag cataaaagca c 201
<210> 1378
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or T
<400> 1378
ggtgatccac ctgcctcggc ctcccaaatg ctgggattac aagcgtgagc caccatgccc 60
agcctatcct ggtaggtttt aatctccttg agaacagaaa ntatgtttat ttcaacatta 120
ttacactagg ggagggactt gaatagttga ccaataaata tatattaagt attaaataaa 180
acagtcttca tgaatttcta a 201
<210> 1379
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1379
aggaaacaat ttgaggataa cactaatttt ctgattgatt atatgtgatc ttgtctgtga 60
gacaaagaaa agtgcagcag aatcaagttt tataggaata ngtaaaatgc tcaaatgtca 120
agcatgtatg agcgacctca ttttctaccg ggattatgag tcacacccat tcatagatgg 180
tgttacacct ttctgtctga t 201
<210> 1380
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1380
cattagggtt ctatttcatg acaataaaaa tacatgctca ttattaaaag tttggaaaac 60
aaaagtcctg acaaaaatta aagcataatt caaccaccta ntaacaaaag ctattaatat 120
tttgatgaat ttccttccag tcttatttcc atgcttgatt tttgtttgtt tatattacat 180
tattatggtt atacttgttg t 201
<210> 1381
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1381
tcaactcctg ggctatcctg tatcctgctt ccttagaaaa ccaaacatct ccatggctgt 60
acttgctaca gaaagggcag aagcaacaga agatcagcct nataagaatc gttttctgac 120
taataaatct cagccatgtg tttctgatta gccggtcttg agccagacag atccagacct 180
tcacgtgcaa gggagtctgg g 201
<210> 1382
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1382
ttggcttgac ttcagatctc agtaggagtg atcggatgcc aacagtggag aaatgggctg 60
ggcaattcct aggcctctga tggcatactt gagtcctgag nggatgaaac tggaccagca 120
gacatatcct gaggtccctt ggcagtctgt tcaggcacca tttatgatag gcagagatgg 180
tcatccccag gccgcctttg g 201
<210> 1383
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1383
atccattttt tcagcatcat attctttctt acattgtaag aatatttttc aagtatttat 60
gtcaattatc cgagaatatt tagagttcca tagacgaaaa ntatgcctcg tatttctttt 120
tactccaaaa caccttgaat agacaaaaat aaaaaacaat tctggtagtc ttatagccac 180
tgtagatata aaagttttat a 201
<210> 1384
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1384
aaacaaaagc accgataaga ttagagtgga gaaatgtaca catagagtcc tttctaattt 60
atgaatatgg aataaccact tgttgggaga gaaaggtagg naaatgtcaa cagtctccca 120
caaagccaca gtggccatag gagaaaacca agtcggttgc ccagcataga tttttctgat 180
tctgagacaa gagaaaagct t 201
<210> 1385
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1385
acaaggagga gaagcttaga gggagttcag cagattttct aagttaagga gacaaacctg 60
agagcctgag aaaacaaaga gggtagagat cacaggaagg ngtcctggaa aagagagagt 120
acaaagaaat acatctagat atctgcagag gatagcctca agtattcagc agagtggtga 180
tcatcagcaa acctatatga g 201
<210> 1386
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1386
aaccaaagca agatcaaaat attatatagc tcaacggtaa tttattttaa ccacttctta 60
ttcatttgac aaatatttac tgaatatcca ctttggacca nttactgggg atacatcact 120
gaataaggat gtcctgttca ctctcatcac attacttaga gtctattaaa ggaatcagag 180
atcaaataat tacagtagga g 201
<210> 1387
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 1387
tgtggtcctt tcacaacatg gccacttctt caaagccagt gggagaatct ctcccttcag 60
gaagggatct gtctctcttt ttaaaggctt ttacctgatt nagtcaggcc ttcctaagat 120
gatctccatt ttgattaatt cattatggtc aaatgatttg agaacttatt tacatctgca 180
aaatctcttc acctttgcca a 201
<210> 1388
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1388
catgccagtg tttcaggttt ttttctaagt attgggattt tcaaaactat gttctggtct 60
atggatagtt tctcattgaa ttttctgttg cagggaagtg naacctgatc cttcctattc 120
tgtgttcttg ctgacatcac tcccctttaa ttatatattt ttaaattcat ttaccatact 180
catgcagtgc agtggaacat a 201
<210> 1389
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or A
<400> 1389
gtattggtgt atctaaaata gaaagtgtac agttaaaata tggtataaac aataaaaatg 60
gtacacctgt ataatcagtt accatgaaag gagcttgcag naatggaatg gaagttgctc 120
tgggtaagtc agtgagtgag tggtaagtca gtgagtgagt ggtaagtcag tgcaaaggcc 180
tgggacatta ctatacagta c 201
<210> 1390
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = C or G
<400> 1390
cacctagagg cacttaccat agttcccatt ttacaggtga ggaaattggg cctggtaagt 60
tgtcacgcct cagatcatgc aactggcaag gcccaggtga ntcaacctca gttttcagtg 120
accacgtagg ctgcctctca atgttggttc ttgggaggct gcttaatagg gtccccttcc 180
agggaagtag caatgctggg a 201
<210> 1391
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1391
gtattcatgt atgaaattgg caaaaattta aaaatcattt ttcagaaatt gggcataagg 60
cttcctgtgg aaatggaaaa ccatctagat ggtgaaacca nctagaaaaa taaattggtg 120
aaatgtataa acagcattaa aaatttctat cattttgaac cagtaatcca acattaaatt 180
ttttatactt aaaagatatt c 201
<210> 1392
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or T
<400> 1392
gctatatgct catgagagaa taagattcta gaacaaataa tggcttacca ctattatgaa 60
aattgttttt atctcatgaa tttctgaaaa tgcctgggga ntccatactt tgagagtctc 120
tgcccaaatt cattgtagtt ctgagatcat cccaaatttt caacaaaaaa gcacataaat 180
tagttgttct ccctagtgac a 201
<210> 1393
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = A or G
<400> 1393
tctgttagga attttgaaaa ggcacaatgg ggatggctta attctactcc atgttgtctg 60
gggcttcagc tgggataact tgaacggctg gggataaccc naacagatgg catctttgct 120
cacatgcatg gtgtctgggc tgggaaggct gaaggatagg ctcagctgca attattaatt 180
agggaccccc tatgtggcct c 201
<210> 1394
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1394
cttagctttt atctgtcttc actccttaac cctggataca gcataggaat cctggttgaa 60
agaggggatg ctgaattttc aacaaggtgt atgtatgatt nggatctgtg gccccaccaa 120
atcttatgtt agattgtaat ctcaatattg gaggtggggc ctggtggaag gtgattggat 180
cttagggttg aatgtctcat t 201
<210> 1395
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or C
<400> 1395
tcctgaataa agtggagaca gtcctcaact tatgtggggg gggaggggta gtgtgtctac 60
ttacaatttt tctaccttac aatgatgtca aagtgataca nattaagtag aaaaaatatt 120
tcagataccc atccagttac tctcttttca ctttccatac agtattcgat aatactgttg 180
aatgagatac ctcacacttt a 201
<210> 1396
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1396
tatatataca cacacatatt tatatatatt cttgggaata tatatgaatt cttaaagcgc 60
aggctacact ccacaccaat taaatcagaa gctctgagta ngaaaatccc agaccatagt 120
tttgtttttt ctttgtttgt ttgttttgtt ttgttttaac ttctcaggtg attccaatgt 180
gcagccaagt tggagaaata c 201
<210> 1397
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or C
<400> 1397
aaactcaggc tcagagttta gttgacatgg gagatctgga atcagagtgc ttaggttcaa 60
acctcaactc tgcctctgac aagctgcttg acgttgggga nagtcgtata aattctaagc 120
atctgttttg tcatctgtga aacagagata agagacatct cggtgtggag attccataag 180
ataatataag tgaagtgatt a 201
<210> 1398
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = G or T
<400> 1398
aaaatatata actgagatcc caactcatga aatccctgac attattaaaa acctgctcct 60
cctcctgttt ttccaatatc aatgaatggt atctatcaat nttcacctgg ctgtcaggcc 120
ggaaaactgg gaatgatatt taattcatct ctctcactca tctctcacat ttaattcatc 180
atcaggttaa ttcagcttcc a 201
<210> 1399
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1399
atgcaatata ttaatatcat gtaacaaact tgcacatgta catcctgaat ctaagatata 60
aggtgaaatt agaaaagtaa aataaaataa aatggggctt ngaaagtttg aaaaatttgc 120
acaaatcaca cagctagtat atggggaagc caaggttcaa attagtaatc agttaagtaa 180
agaccaagat cagaaagata a 201
<210> 1400
<211> 201
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (101)
<223> n = T or A
<400> 1400
ttggtgccct gatctcttga ctccatcctc tgatctctta ctgatgtctt ccattggctg 60
aactaaactg gaagccaaag gacaaggaaa tctatagagg ncagctccaa ggcacagagc 120
agaacagagc atggatctgg agaggctaat atccagttca cttgccccaa acaaaatcat 180
cttctctcta ccgcctttcc c 201
Claims (16)
- 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 단일염기다형성(single nucleotide polymorphism, SNP)을 증폭 또는 검출하는 제제를 포함하는, 한국인 친족관계 확인용 조성물.
- 제1항에 있어서, 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP를 증폭 또는 검출하는 제제를 추가적으로 포함하는, 한국인 친족관계 확인용 조성물.
- 제1항 또는 제2항에 있어서, 상기 제제는 프라이머, 프로브, 또는 이들의 조합인 것인, 한국인 친족관계 확인용 조성물.
- 제1항 또는 제2항에 있어서, 상기 친족관계는 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나인 것인, 한국인 친족관계 확인용 조성물.
- 제1항 또는 제2항의 한국인 친족관계 확인용 조성물을 포함하는 한국인 친족관계 확인용 키트.
- 제5항에 있어서, 상기 키트는 마이크로어레이(microarray)인, 한국인 친족관계 확인용 키트.
- 친족관계를 확인하고자 하는 2인 이상의 대상으로부터 분리된 시료에 대하여, 서열번호 919 내지 서열번호 1400에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP의 염기 종류를 확인하는 단계를 포함하는 한국인 친족관계 확인 방법.
- 제7항에 있어서, 상기 친족관계를 확인하고자 하는 2인 이상의 대상으로부터 분리된 시료에 대하여, 서열번호 1 내지 서열번호 918에 나타낸 뉴클레오타이드 서열 중 적어도 하나의 서열에서 101번째 염기에 위치한 SNP의 염기 종류를 확인하는 단계를 추가적으로 포함하는, 방법.
- 제7항 또는 제8항에 있어서, 상기 친족관계는 본인을 기준으로 부모, 자식, 형제, 자매 및 남매 중 어느 하나인 것인, 방법.
- 제7항 또는 제8항에 있어서, 상기 SNP의 염기 종류를 확인하는 단계는 프라이머, 프로브, 또는 이들의 조합을 이용하여 SNP를 증폭 또는 검출하는 것인, 방법.
- 제7항 또는 제8항에 있어서, 상기 SNP의 염기 종류를 확인하는 단계 이후 각 시료의 각 SNP 염기 종류를 서로 쌍으로(pairwise) 비교하는 단계를 추가적으로 포함하는, 방법.
- 제11항에 있어서, 상기 각 시료의 각 SNP 염기 종류를 서로 쌍으로(pairwise) 비교하는 단계는 다음 단계를 포함하는 것인, 방법:
(a) i) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 동일한 경우 IBS 점수 2 (Identity by state 2)로 지정하거나, ii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 하나만 동일한 경우 IBS 점수 1로 지정하거나, 또는 iii) 쌍으로 비교하는 두 시료로부터 확인한, 두 대립유전자에서 해당 SNP 염기 종류가 모두 상이한 경우 IBS 점수 0으로 지정하는 단계; 및
(b) 쌍으로 비교한 모든 상기 SNP에 대한 IBS 점수의 평균을 구하는 단계.
- 제12항에 있어서, 상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.310 내지 0.700인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계일 가능성이 있다는 정보를 제공하거나; 또는
상기 평균을 구하는 단계에서 수득한 평균 IBS 점수가 0.310 미만인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계가 아닐 가능성이 있다는 정보를 제공하는 것인, 방법.
- 제13항에 있어서, 상기 평균 IBS 점수가 0.340 내지 0.700인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계일 가능성이 있다는 정보를 제공하거나; 또는
상기 평균 IBS 점수가 0.340 미만인 경우 쌍으로 비교한 두 시료를 분리한 상기 두 대상이 부모, 자식, 형제, 자매 및 남매 중 어느 하나의 친족관계가 아닐 가능성이 있다는 정보를 제공하는 것인, 방법.
- 인간 유전체 데이터베이스에서 다음 중 적어도 하나의 특징을 나타내는 SNP를 추출하는 단계를 포함하는 친족관계 확인을 위한 SNP 마커 발굴 방법:
- 하디-바인베르크 평형(Hardy-Weinberg equilibrium, HWE)에서 p 값이 0.05 이상인 SNP;
- 유전자 영역 내, 또는 유전자 영역의 100 kbp 업스트림 또는 다운스트림에 존재하지 않는 SNP;
- 대립유전자 빈도가 0.4 내지 0.6인 SNP;
- 연관 비평형에 존재하지 않는 SNP; 및
- 유전체 반복 영역에 존재하지 않는 SNP.
- 제15항에 있어서, 상기 유전자 영역은 엑손(exon) 또는 코딩 서열(coding sequence)인 것인, SNP 마커 발굴 방법.
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