KR20230144853A - 식물체의 재분화 효율을 조절하는 애기장대 유래 유전자 및 이의 용도 - Google Patents
식물체의 재분화 효율을 조절하는 애기장대 유래 유전자 및 이의 용도 Download PDFInfo
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Abstract
본 발명은 식물체의 재분화 효율을 조절하는 애기장대 유래 유전자 및 이의 용도에 관한 것으로, 보다 구체적으로는 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 유전자의 발현을 식물세포에서 저해시켜 야생형에 비해 식물체의 지상부 재분화 효율을 감소시키는 방법에 관한 것이다.
Description
본 발명은 식물체의 재분화 효율을 조절하는 애기장대 유래 유전자 및 이의 용도에 관한 것이다.
식물의 재분화(regeneration)는 작물의 게놈(genome) 편집, 형질전환 등 유전공학적 응용에 필수적인 기술로서, 낮은 재분화 효율은 게놈 편집의 주요한 허들로 알려져 있다. 고부가가치의 작물을 농생명공학적으로 육종하기 위해서는 게놈 편집 또는 형질전환후 조직의 탈분화(캘러스 형성, callus formation)와 지상부 재분화(shoot regeneration)가 순차적으로 수행된다. 이때 식물 재분화 과정의 효율이 매우 낮아 주요 작물의 형질개량이 매우 제한적으로 이루어지고 있는 상황이다.
최근 크리스퍼(CRISPR) 기술의 발전과 함께 정밀 육종의 수요와 시장이 폭발적으로 성장하고 있으며, 식물 재분화 기술은 해당 시장에서 필수적으로 요구되는 바, 혁신적인 문제점 개선을 위해 전세계적으로 노력이 집중되고 있다. 일반적으로, 식물의 재분화 효율 증진을 위해 재분화 유도배지에 다양한 호르몬과 첨가물을 배합하는 방식으로 재분화 증진을 도모하였으나, 뚜렷한 한계에 직면하고 있다.
식물의 낮은 재분화 효율은 유전적 장벽 때문인 것으로 알려져 있는데, 식물의 유전적인 요인에 의해 재분화 효율이 이미 결정되는 상황이기 때문에 재분화 과정을 방해하는 유전자의 제거가 재분화 증진을 가능하게 하는 핵심기술로 알려지고 있다. 따라서 재분화 효율 조절에 관여하는 유전자를 확보하고 해당 유전자의 발현 조절을 통해 작물의 재분화 효율을 증진하는 방법의 연구가 필요하다.
한편, 한국등록특허 제1898392호에는 '애기장대 유래 ATX4 유전자를 이용한 식물체의 재분화 효율 증가 방법 및 그에 따른 식물체'가 개시되어 있고, 한국등록특허 제2125714호에는 '식물체의 재분화 효율을 조절하는 애기장대 유래 DEMETER 유전자 및 이의 용도'가 개시되어 있으나, 본 발명의 '식물체의 재분화 효율을 조절하는 애기장대 유래 유전자 및 이의 용도'에 대해서는 기재된 바가 없다.
본 발명은 상기와 같은 요구에 의해 도출된 것으로서, 본 발명에서는 지상부 재분화 과정에 관여할 것으로 예상되는 유전자들의 녹아웃(knock-out) 돌연변이체를 이용하여, 지상부 재분화 과정에 어떠한 영향이 있는지 분석한 결과, PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 유전자가 녹아웃된 돌연변이체의 재분화 효율이 야생형에 비해 현저하게 감소하는 것을 확인함으로써, 본 발명을 완성하였다.
상기 과제를 해결하기 위해, 본 발명은 애기장대 유래 PRR9/7/5(Pseudo Response Regulator9/7/5), CCA1/LHY(Circadian Clock-Associated 1/Late Elongated Hypocotyl), FIP37(FKBP12 Interacting Protein 37), CML10(Calmodulin-Like Protein), PDAT1(Phospholipid:Diacylglycerol Acyltransferase 1), SKM1/2(Sterility Rugulating Kinase Member1/2), CRY1(Cryptochrome 1), NUP160(Nucleoporin 160) 또는 NUP98a1/b1(Nucleoporin 98a1/b1) 단백질을 코딩하는 유전자의 발현을 식물세포에서 조절하는 단계를 포함하는, 식물체의 재분화(regeneration) 효율을 조절하는 방법을 제공한다.
또한, 본 발명은 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자를 포함하는 재조합 벡터로 식물세포를 형질전환하는 단계를 포함하는, 재분화 효율이 조절된 형질전환 식물체의 제조방법을 제공한다.
또한, 본 발명은 상기 방법에 의해 제조된 재분화 효율이 조절된 형질전환 식물체 및 이의 형질전환된 종자를 제공한다.
또한, 본 발명은 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자의 발현이 저해되어, 야생형에 비해 재분화 효율이 감소된 돌연변이 식물체를 제공한다.
또한, 본 발명은 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자를 유효성분으로 포함하는, 식물체의 재분화 효율 조절용 조성물을 제공한다.
본 발명에서는 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 유전자의 발현 조절을 통해 식물체의 재분화 효율을 조절할 수 있음을 확인하였으므로, 상기 유전자들을 이용하면, 작물 형질전환 효율을 증진시킬 수 있을 것이며, 육종연한을 단축시키고 육종 과정의 효율화를 가능하게 할 수 있을 것으로 기대된다.
도 1은 야생형(Col-0)과 각 유전자 녹아웃 돌연변이체의 하배축 절편체 유래 캘러스를 신초 유도배지에 동일기간 배양하였을 때 형성된 신초의 개수를 확인한 결과로, A는 PRR9/7/5 녹아웃 돌연변이체(prr975)의 결과이고, B는 CCA1/LHY 녹아웃 돌연변이체(cca1lhy)의 결과이고, C는 FIP37 녹아웃 돌연변이체(fip37-4/+LEC1:FIP37)의 결과이고, D는 CML10 녹아웃 돌연변이체(cml10-2)의 결과이고, E는 PDAT1 녹아웃 돌연변이체(pdat1-8)의 결과이고, F는 SKM1/2 녹아웃 돌연변이체(skm1 skm2)의 결과이고, G는 CRY1 녹아웃 돌연변이체(cry1-1)의 결과이고, H는 NUP160 녹아웃 돌연변이체(nup160-4)의 결과이며 I는 NUP98a1/b1 녹아웃 돌연변이체(nup98a1xnup98b1)의 결과이다.
본 발명의 목적을 달성하기 위하여, 본 발명은 애기장대 유래 PRR9/7/5(Pseudo Response Regulator9/7/5), CCA1/LHY(Circadian Clock-Associated 1/Late Elongated Hypocotyl), FIP37(FKBP12 Interacting Protein 37), CML10(Calmodulin-Like Protein), PDAT1(Phospholipid:Diacylglycerol Acyltransferase 1), SKM1/2(Sterility Rugulating Kinase Member1/2), CRY1(Cryptochrome 1), NUP160(Nucleoporin 160) 또는 NUP98a1/b1(Nucleoporin 98a1/b1) 단백질을 코딩하는 유전자의 발현을 식물세포에서 조절하는 단계를 포함하는, 식물체의 재분화(regeneration) 효율을 조절하는 방법을 제공한다.
본 발명에 따른 식물체의 재분화 효율을 조절하는 방법에 있어서, 상기 PRR9/7/5 단백질은 각각 순서대로 PRR9, PRR7, PRR5 단백질을 의미하는 것이고, 상기 CCA1/LHY 단백질은 각각 CCA1, LHY 단백질을 의미하는 것이고, SKM1/2 단백질은 각각 SKM1, SKM2 단백질을 의미하는 것이며, NUP98a1/b1 단백질은 각각 NUP98a1, NUP98b1 단백질을 의미하는 것으로, 이들의 녹아웃 돌연변이체는 다중 돌연변이체이다.
본 발명에 따른 식물체의 재분화 효율을 조절하는 방법에 있어서, 상기 PRR9/7/5 단백질은 각각 순서대로 서열번호 1 내지 3의 아미노산 서열을, 상기 CCA1/LHY 단백질은 각각 서열번호 4 또는 5의 아미노산 서열을, 상기 FIP37 단백질은 서열번호 6의 아미노산 서열을, 상기 CML10 단백질은 서열번호 7의 아미노산 서열을, 상기 PDAT1 단백질은 서열번호 8의 아미노산 서열을, 상기 SKM1/2 단백질은 각각 서열번호 9 또는 10의 아미노산 서열을, 상기 CRY1 단백질은 서열번호 11의 아미노산 서열을, 상기 NUP160 단백질은 서열번호 12의 아미노산 서열을, 상기 NUP98a1/b1 단백질은 각각 서열번호 13 또는 14의 아미노산 서열을 갖는 단백질 및 상기 단백질의 기능적 동등물을 포함한다. "기능적 동등물"이란 아미노산의 부가, 치환 또는 결실의 결과, 상기 서열번호 1 내지 14로 표시되는 아미노산 서열과 각각 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더 더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1 내지 14로 표시되는 단백질과 실질적으로 동질의 생리활성을 나타내는 단백질을 말한다. "실질적으로 동질의 생리활성"이란 식물체의 재분화 효율을 조절하는 활성을 의미한다.
또한, 본 발명은 상기 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자를 제공한다. 상기 유전자는 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 암호화하는 게놈 DNA와 cDNA를 모두 포함한다. 본 발명의 애기장대 유래 PRR9/7/5 유전자는 각각 순서대로 서열번호 15 내지 17로 표시되는 염기서열을 포함할 수 있고, CCA1/LHY 유전자는 각각 서열번호 18 내지 19로 표시되는 염기서열을 포함할 수 있고, FIP37 유전자는 서열번호 20으로 표시되는 염기서열을 포함할 수 있고, CML10 유전자는 서열번호 21로 표시되는 염기서열을 포함할 수 있고, PDAT1 유전자는 서열번호 22로 표시되는 염기서열을 포함할 수 있고, SKM1/2 유전자는 각각 서열번호 23 또는 24로 표시되는 염기서열을 포함할 수 있고, CRY1 유전자는 서열번호 25로 표시되는 염기서열을 포함할 수 있고, NUP160 유전자는 서열번호 26으로 표시되는 염기서열을 포함할 수 있고, NUP98a1/b1 유전자는 각각 서열번호 27 또는 28로 표시되는 염기서열을 포함할 수 있다. 또한, 상기 염기서열의 상동체가 본 발명의 범위 내에 포함된다. 구체적으로, 상기 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자는 서열번호 15 내지 28의 염기서열과 각각 70% 이상, 더욱 바람직하게는 80% 이상, 더 더욱 바람직하게는 90% 이상, 가장 바람직하게는 95% 이상의 서열 상동성을 가지는 염기서열을 포함할 수 있다. 폴리뉴클레오티드에 대한 "서열 상동성의 %"는 두 개의 최적으로 배열된 서열과 비교 영역을 비교함으로써 확인되며, 비교 영역에서의 폴리뉴클레오티드 서열의 일부는 두 서열의 최적 배열에 대한 참고 서열(추가 또는 삭제를 포함하지 않음)에 비해 추가 또는 삭제(즉, 갭)를 포함할 수 있다.
본 발명의 일 구현 예에 따른 식물체의 재분화 효율 조절 방법에 있어서, 상기 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자의 발현 조절은 바람직하게는 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질 코딩 유전자의 발현이 저해된 것으로, 식물세포에서 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질 코딩 유전자의 발현 저해는 야생형에 비해 식물체의 재분화 효율을 감소시켰다.
상기 PRR9/7/5, CCA1/LHY, SKM1/2 또는 NUP98a1/b1 단백질 코딩 유전자의 발현 저해는 다중 돌연변이체를 이루는 각 유전자가 모두 발현이 저해되었을 때 야생형에 비해 식물체의 재분화 효율을 감소시키는 것이 특징이다.
또한, 본 발명에 있어서, 상기 감소된 재분화 효율은 바람직하게는 지상부 재분화(shoot regeneration)를 감소시키는 것일 수 있으나, 이에 제한되는 것은 아니다.
본 발명의 일 구현 예에 있어서, 상기 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자의 발현 저해는 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질 코딩 유전자에 T-DNA 삽입, 내생 트랜스포존(transposon), X-레이 또는 γ-레이 조사를 통한 돌연변이 유발, VIGS(Virus-induced gene silencing) 벡터, RNAi(RNA interference) 또는 안티센스 RNA, CRISPR/Cas9 유전자 교정 시스템을 이용하여 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질 코딩 유전자의 발현을 저해(억제)하는 것일 수 있으나, 이에 제한되지 않으며, 유전자의 발현을 저해하는 당업계의 통상의 방법이면 모두 가능할 수 있다.
본 발명은 또한, 애기장대 유래 PRR9/7/5(Pseudo Response Regulator9/7/5), CCA1/LHY(Circadian Clock-Associated 1/Late Elongated Hypocotyl), FIP37(FKBP12 Interacting Protein 37), CML10(Calmodulin-Like Protein), PDAT1(Phospholipid:Diacylglycerol Acyltransferase 1), SKM1/2(Sterility Rugulating Kinase Member1/2), CRY1(Cryptochrome 1), NUP160(Nucleoporin 160) 또는 NUP98a1/b1(Nucleoporin 98a1/b1) 단백질을 코딩하는 유전자를 포함하는 재조합 벡터로 식물세포를 형질전환하는 단계를 포함하는, 재분화 효율이 조절된 형질전환 식물체의 제조방법을 제공한다.
본 발명의 제조방법에 있어서, 상기 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질 및 이의 유전자는 전술한 것과 같다.
본 발명의 일 구현 예에 따른 제조방법은 상기 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자의 발현을 식물세포에서 저해시켜 야생형에 비해 식물체의 재분화 효율을 감소시키는 것을 특징으로 하나, 이에 제한되지 않는다.
본 명세서에서 용어 "재조합"은 세포가 이종의 핵산을 복제하거나, 상기 핵산을 발현하거나 또는 펩티드, 이종의 펩티드 또는 이종의 핵산에 의해 암호된 단백질을 발현하는 세포를 지칭하는 것이다. 재조합 세포는 상기 세포의 천연 형태에서는 발견되지 않는 유전자 또는 유전자 절편을, 센스 또는 안티센스 형태 중 하나로 발현할 수 있다. 또한 재조합 세포는 천연 상태의 세포에서 발견되는 유전자를 발현할 수 있으며, 그러나 상기 유전자는 변형된 것으로서 인위적인 수단에 의해 세포내 재도입된 것이다.
본 명세서에서 용어 "벡터"는 세포 내로 전달하는 DNA 단편(들), 핵산 분자를 지칭할 때 사용된다. 벡터는 DNA를 복제시키고, 숙주세포에서 독립적으로 재생산될 수 있다. 용어 "전달체"는 흔히 "벡터"와 호환하여 사용된다. 용어 "발현 벡터"는 목적한 코딩 서열과, 특정 숙주 생물에서 작동가능하게 연결된 코딩 서열을 발현하는데 필수적인 적정 핵산 서열을 포함하는 재조합 DNA 분자를 의미한다. 진핵세포에서 이용 가능한 프로모터, 인핸서, 종결신호 및 폴리아데닐레이션 신호는 공지되어 있다.
본 발명의 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자 서열 및 적당한 전사/번역 조절 신호를 포함하는 발현 벡터는 당업자에 주지된 방법에 의해 구축될 수 있다. 상기 방법은 시험관내 재조합 DNA 기술, DNA 합성 기술 및 생체 내 재조합 기술 등을 포함한다. 상기 DNA 서열은 mRNA 합성을 이끌기 위해 발현 벡터 내의 적당한 프로모터에 효과적으로 연결될 수 있다. 또한 발현 벡터는 번역 개시 부위로서 리보좀 결합 부위 및 전사 터미네이터를 포함할 수 있다.
본 발명의 재조합 벡터의 바람직한 예는 VIGS 벡터 또는 RNAi 벡터이다. VIGS는 바이러스 벡터에 식물유전자를 도입한 후 식물체를 감염시키면, 그 도입된 유전자의 내인성 식물 유전자가 발현이 억제되는 현상을 말한다. 이는 PTGS(Post-transcriptional gene silencing)의 일종으로서, 전사-후(post-transcriptional), RNA 턴오버(RNA turnover) 및 뉴클레오티드 서열 특이적(nucleotide sequence-specific) 이라는 특징들을 가진다. 상기 VIGS 벡터는 외래 유전자를 도입한 식물체 내에서 일시적으로 발현시킬 수 있는 일시적(transient) 발현 벡터 및 외래 유전자가 도입된 식물체에서 영구적으로 발현시킬 수 있는 식물 발현 벡터로 사용할 수 있다.
식물 발현 벡터의 바람직한 예는 아그로박테리움 투머파시엔스(Agrobacterium tumefaciens)와 같은 적당한 숙주에 존재할 때 그 자체의 일부, 소위 T-영역을 식물 세포로 전이시킬 수 있는 Ti-플라스미드 벡터이다. 다른 유형의 Ti-플라스미드 벡터(EP 0 116 718 B1호 참조)는 현재 식물 세포, 또는 잡종 DNA를 식물의 게놈 내에 적당하게 삽입시키는 새로운 식물이 생산될 수 있는 원형질체로 잡종 DNA 서열을 전이시키는데 이용되고 있다. Ti-플라스미드 벡터의 특히 바람직한 형태는 EP 0 120 516 B1호 및 미국 특허 제4,940,838호에 청구된 바와 같은 소위 바이너리(binary) 벡터이다. 본 발명에 따른 DNA를 식물 숙주에 도입시키는데 이용될 수 있는 다른 적합한 벡터는 이중 가닥 식물 바이러스(예를 들면, CaMV) 및 단일 가닥 바이러스, 게미니 바이러스 등으로부터 유래될 수 있는 것과 같은 바이러스 벡터, 예를 들면 비완전성 식물 바이러스 벡터로부터 선택될 수 있다. 그러한 벡터의 사용은 특히 식물 숙주를 적당하게 형질전환하는 것이 어려울 때 유리할 수 있다.
발현 벡터는 바람직하게는 하나 이상의 선택성 마커를 포함할 것이다. 상기 마커는 통상적으로 화학적인 방법으로 선택될 수 있는 특성을 갖는 핵산 서열로, 형질전환된 세포를 비형질전환 세포로부터 구별할 수 있는 모든 유전자가 이에 해당된다. 그 예로는 글리포세이트(glyphosate), 포스피노트리신(phosphinothricin) 및 글루포시네이트(glufosinate)와 같은 제초제 저항성 유전자, 카나마이신(kanamycin), G418, 블레오마이신(bleomycin), 하이그로마이신(hygromycin), 클로람페니콜(chloramphenicol)과 같은 항생제 내성 유전자가 있으나, 이에 한정되는 것은 아니다.
본 발명의 식물 발현 벡터에서, 프로모터는 바람직하게는 T7 프로모터, SP6 프로모터, CaMV 35S 프로모터, 액틴 프로모터, 유비퀴틴 프로모터, pEMU 프로모터, MAS 프로모터 또는 히스톤 프로모터일 수 있으나, 이에 제한되지 않는다. 용어 "프로모터"란 구조 유전자로부터의 DNA 업스트림의 영역을 의미하며 전사를 개시하기 위하여 RNA 폴리머라아제가 결합하는 DNA 분자를 말한다. "식물 프로모터"는 식물 세포에서 전사를 개시할 수 있는 프로모터이다. "구성적(constitutive) 프로모터"는 대부분의 환경 조건 및 발달 상태 또는 세포 분화하에서 활성이 있는 프로모터이다. 형질전환체의 선택이 각종 단계에서 각종 조직에 의해서 이루어질 수 있기 때문에 구성적 프로모터가 본 발명에서 바람직할 수 있다. 따라서, 구성적 프로모터는 선택 가능성을 제한하지 않는다.
본 발명의 재조합 벡터에서, 통상의 터미네이터를 사용할 수 있으며, 그 예로는 노팔린 신타아제(Nopaline synthase), 벼 α-아밀라아제 RAmy1 A 터미네이터, 파세올린(Phaseolin) 터미네이터, 아그로박테리움 투메파시엔스(A. tumefaciens)의 옥토파인 신타아제(Octopine synthase) 유전자의 터미네이터, 대장균의 rrnB1/B2 터미네이터 등이 있으나, 이에 한정되는 것은 아니다. 터미네이터의 필요성에 관하여, 그러한 영역이 식물세포에서의 전사의 확실성 및 효율을 증가시키는 것으로 일반적으로 알려져 있다. 그러므로, 터미네이터의 사용은 본 발명의 내용에서 매우 바람직하다.
본 발명의 벡터를 숙주세포 내로 운반하는 방법은 원형질체에 대한 칼슘/폴리에틸렌 글리콜 방법(Krens, F.A. et al., 1982, Nature 296, 72-74; Negrutiu I. et al., June 1987, Plant Mol. Biol. 8, 363-373), 원형질체의 전기천공법(Shillito R.D. et al., 1985 Bio/Technol. 3, 1099-1102), 식물 요소로의 현미주사법(Crossway A. et al., 1986, Mol. Gen. Genet. 202, 179-185), 각종 식물 요소의(DNA 또는 RNA-코팅된) 입자 충격법(Klein T.M. et al., 1987, Nature 327, 70), 식물의 침윤 또는 성숙 화분 또는 소포자의 형질전환에 의한 아그로박테리움 투머파시엔스 매개된 유전자 전이에서(비완전성) 바이러스에 의한 감염(EP 0 301 316호) 등으로부터 적당하게 선택될 수 있다.
또한, 본 발명의 제조방법은 상기 형질전환된 식물세포로부터 형질전환 전식물로 재분화하는 단계를 포함한다. 형질전환 식물세포로부터 형질전환 전식물을 재분화하는 방법은 당업계에 공지된 임의의 방법을 이용할 수 있다.
식물의 형질전환에 이용되는 "식물세포"는 어떤 식물세포도 된다. 식물세포는 배양 세포, 배양 조직, 배양기관 또는 전체 식물이다. "식물 조직"은 분화된 또는 미분화된 식물의 조직, 예를 들면 이에 한정되진 않으나, 뿌리, 줄기, 잎, 꽃가루, 종자, 암 조직 및 배양에 이용되는 다양한 형태의 세포들, 즉 단일 세포, 원형질체(protoplast), 싹 및 캘러스 조직을 포함한다. 식물 조직은 인 플란타(in planta)이거나 기관 배양, 조직배양 또는 세포 배양 상태일 수 있다.
또한, 본 발명은 상기 제조방법에 의해 제조된 재분화 효율이 조절된 형질전환 식물체 및 이의 종자를 제공한다. 바람직하게는, 상기 형질전환 식물체 및 이의 종자는 야생형에 비해 재분화 효율이 감소된 형질전환 식물체 및 이의 종자이다.
상기 식물체는 애기장대, 감자, 가지, 담배, 고추, 토마토, 우엉, 쑥갓, 상추, 도라지, 시금치, 근대, 고구마, 샐러리, 당근, 미나리, 파슬리, 배추, 양배추, 갓무, 수박, 참외, 오이, 호박, 박, 딸기, 대두, 녹두, 강낭콩, 완두 등의 쌍자엽 식물 또는 벼, 보리, 밀, 호밀, 옥수수, 사탕수수, 귀리, 양파 등의 단자엽 식물일 수 있으며, 바람직하게는 쌍자엽 식물이며, 더욱 바람직하게는 애기장대 식물체일 수 있으나, 이에 제한되지 않는다.
본 발명은 또한, 애기장대 유래 PRR9/7/5(Pseudo Response Regulator9/7/5), CCA1/LHY(Circadian Clock-Associated 1/Late Elongated Hypocotyl), FIP37(FKBP12 Interacting Protein 37), CML10(Calmodulin-Like Protein), PDAT1(Phospholipid:Diacylglycerol Acyltransferase 1), SKM1/2(Sterility Rugulating Kinase Member1/2), CRY1(Cryptochrome 1), NUP160(Nucleoporin 160) 또는 NUP98a1/b1(Nucleoporin 98a1/b1) 단백질을 코딩하는 유전자를 유효성분으로 포함하는, 식물체의 재분화 효율 조절용 조성물을 제공한다.
본 발명의 조성물은 유효성분으로 식물체의 재분화 효율을 조절할 수 있는 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질 코딩 유전자를 포함하며, 상기 유전자의 발현이 저해되면 식물체의 재분화 효율이 감소될 수 있다. 상기 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질 코딩 유전자는 전술한 것과 같다.
이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.
1. 식물 재료 및 성장 조건
본 발명에서는 Columbia-0 생태형 애기장대(Col-0)를 야생형으로 사용하였다. 애기장대 종자의 표면을 멸균한 후, 1/2 MS(Murashige and Skoog)를 포함하는 0.7% 아가 플레이트에 심었다. 식물은 22~23℃에서 백색 형광등(120 μmol photons·m-2·s-1)을 사용하여 장일조건(16 시간 광/8 시간 암주기)으로 재배되었다.
CML10 녹아웃 돌연변이체(cml10-2, stock number CS872725), CRY1 녹아웃 돌연변이체(cry1-1, stock number CS70) 또는 NUP160 녹아웃 돌연변이체(nup160-4, stock number CS69986)는 ABRC (https://abrc.osu.edu/)로부터 구매하여 사용하였고, FIP37 녹아웃 돌연변이체(fip37-4/+LEC1:FIP37), PRR9/7/5 녹아웃 돌연변이체(prr975), CCA1/LHY 녹아웃 돌연변이체(cca1lhy), SKM1/2 녹아웃 돌연변이체(skm1 skm2) 또는 NUP98a1/b1 녹아웃 돌연변이체(nup98a1xnup98b1)는 하기 표 1에 개시된 논문의 저자로부터 각각 제공받아 사용하였으며, PDAT1 녹아웃 돌연변이체(pdat1-8)는 세종대학교 김현욱 교수님 실험실로부터 제공받아 사용하였다.
| 녹아웃 돌연변이체 | 논문 정보 |
| FIP37 녹아웃 돌연변이체 (fip37-4/+LEC1:FIP37) |
Lisha Shen et al., Developmental Cell.2016.38(2);186-200 |
| PRR9/7/5 녹아웃 돌연변이체 (prr975) |
Norihito Nakamichi et al., Plant Cell Physiol.2007.48(6):822-32 |
| CCA1/LHY 녹아웃 돌연변이체 (cca1lhy) |
|
| SKM1/2 녹아웃 돌연변이체 (skm1 skm2) |
Satoshi Endo et al., Curr Biol.2013.23(17):1670-6 |
| NUP98a1/b1 녹아웃 돌연변이체 (nup98a1xnup98b1) |
Long Xiao et al., BMC Plant Biol.2020.20(1):1-15 |
2. 지상부 재분화(shoot regeneration)
지상부 재분화를 위해, 7일령 식물체의 하배축 절편체를 캘러스 유도배지[callus-inducing medium(CIM); 0.5 ㎍/㎖ 2,4-디클로로페녹시아세트산(2,4-D) 및 0.05 ㎍/㎖ 키네틴이 보충된 MS 배지]에서 22℃의 조건으로 7일간 암배양하였다. 그 후, 상기 유도된 캘러스를 CIM에서 7일 동안 전배양한 후, 신초 유도배지[shoot-inducing medium(SIM); 0.9 μmol/L 3-인돌아세트산, 2.5 μmol/L 2-이소펜테닐아데닌이 보충된 MS 배지]에서 25℃, 연속광 조건 하에서 18일 동안 배양하였다.
실시예 1. 야생형과 돌연변이체의 지상부 재분화능 분석
식물체의 재분화는 캘러스 유도와 de novo 지상부 기관형성(organogenesis)을 포함하는 두 단계 과정을 포함한다. 먼저 조직 절편체는 옥신이 풍부한 캘러스 유도배지(CIM)에 배양하여 분화된 체세포로부터 캘러스 형성을 자극시킨다. 옥신 생합성과 캘러스 형성 과정에는 많은 유전자들이 관여하는데, 그 중 대표적인 유전자가 ARFs(AUXIN RESPONSE FACTORs)와 LBDs(LATERAL ORGAN BOUNDARIES DOMAINs)이다. 다능성(pluripotent)의 캘러스는 그 후 옥신 대비 시토키닌(cytokinin)의 높은 비율을 포함하는 신초 유도배지(SIM)로 옮겨 de novo 신초 형성을 유도하게 되고, 특히, 시토키닌 신호전달의 양성 조절자인 type B-ARR(ARABIDOPSIS RESPONSE REGULATOR) 단백질에 의해 주로 조절된다. in vitro 식물의 재분화에는 많은 유전적 요소들이 관여한다는 연구가 보고되고 있으며, 재분화능은 주로 유전적 배경에 의해 결정되므로 본 발명자는 식물의 재분화에 관여하는 유전자를 스크리닝하고자, 다양한 녹아웃 돌연변이체를 이용하여 식물의 재분화능을 확인하였다.
야생형 애기장대와 각 녹아웃 돌연변이체의 하배축 절편체를 캘러스 유도배지에서 7일 동안 배양하여 유래한 캘러스를 신초 유도배지로 옮겨 18일 동안 배양한 후, 지상부 재분화능을 평가하기 위하여 캘러스로부터 형성된 신초의 개수를 확인하였다.
그 결과, PRR9/7/5 녹아웃 돌연변이체(prr975), CCA1/LHY 녹아웃 돌연변이체(cca1lhy), FIP37 녹아웃 돌연변이체(fip37-4/+LEC1:FIP37), CML10 녹아웃 돌연변이체(cml10-2), PDAT1 녹아웃 돌연변이체(pdat1-8), SKM1/2 녹아웃 돌연변이체(skm1 skm2), CRY1 녹아웃 돌연변이체(cry1-1), NUP160 녹아웃 돌연변이체(nup160-4) 또는 NUP98a1/b1 녹아웃 돌연변이체(nup98a1xnup98b1) 유래 캘러스에서 형성된 신초의 개수가 야생형에 비해 현저히 적은 것을 확인하였다(도 1).
상기 결과를 통해, PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 유전자를 과발현시킨다면 식물의 재분화 효율을 증진시킬 수 있음을 유추할 수 있었다.
본 결과물은 삼성미래기술육성사업(SSTF-BA2001-10)의 지원을 받아 연구되었습니다.
<110> Seoul National University R&DB Foundation
<120> Gene from Arabidopsis thaliana for regulating regeneration
efficiency of plant and uses thereof
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Asp Arg Ser Ser Cys Gly Ser Asn Thr Pro Ser Gly Ser Asp Ala Glu
465 470 475 480
Thr Asp Ala Leu Asp Lys Met Glu Lys Asp Lys Glu Asp Val Lys Glu
485 490 495
Thr Asp Glu Asn Gln Pro Asp Val Ile Glu Leu Asn Asn Arg Lys Ile
500 505 510
Lys Met Arg Asp Asn Asn Ser Asn Asn Asn Ala Thr Thr Asp Ser Trp
515 520 525
Lys Glu Val Ser Glu Glu Gly Arg Ile Ala Phe Gln Ala Leu Phe Ala
530 535 540
Arg Glu Arg Leu Pro Gln Ser Phe Ser Pro Pro Gln Val Ala Glu Asn
545 550 555 560
Val Asn Arg Lys Gln Ser Asp Thr Ser Met Pro Leu Ala Pro Asn Phe
565 570 575
Lys Ser Gln Asp Ser Cys Ala Ala Asp Gln Glu Gly Val Val Met Ile
580 585 590
Gly Val Gly Thr Cys Lys Ser Leu Lys Thr Arg Gln Thr Gly Phe Lys
595 600 605
Pro Tyr Lys Arg Cys Ser Met Glu Val Lys Glu Ser Gln Val Gly Asn
610 615 620
Ile Asn Asn Gln Ser Asp Glu Lys Val Cys Lys Arg Leu Arg Leu Glu
625 630 635 640
Gly Glu Ala Ser Thr
645
<210> 6
<211> 330
<212> PRT
<213> Arabidopsis thaliana
<400> 6
Met Glu Phe Ser Ser Gln Asp Asp Asp Phe Gly Gly Asp Asp Ser Ala
1 5 10 15
Ala Asn Ala Thr Arg Ala Ser Gly Asn Arg Arg Ser Phe Gly Asp Leu
20 25 30
Glu Asp Asp Glu Asp Asp Ile Phe Gly Ser Thr Thr Val Ala Pro Gly
35 40 45
Val Arg Thr Gly Met Ile Leu Ser Leu Arg Gly Ser Leu Lys Asn Cys
50 55 60
Lys Asp Asp Leu Ala Ser Cys Gln Asn Glu Leu Glu Ser Ala Lys Thr
65 70 75 80
Glu Ile Gln Lys Trp Lys Ser Ala Phe Gln Asn Glu Ser Phe Val Pro
85 90 95
Ala Gly Lys Ser Pro Glu Pro Arg Phe Leu Ile Asp Tyr Ile Gln Asn
100 105 110
Leu Lys Ser Ser Glu Lys Ser Leu Lys Glu Gln Leu Glu Ile Ala Lys
115 120 125
Arg Lys Glu Ala Ser Cys Ile Val Gln Tyr Ala Lys Arg Glu Gln Glu
130 135 140
Met Ala Glu Leu Lys Ser Ala Val Arg Asp Leu Lys Ser Gln Leu Lys
145 150 155 160
Pro Ala Ser Met Gln Ala Arg Arg Leu Leu Leu Asp Pro Ala Ile His
165 170 175
Glu Glu Phe Ser Arg Leu Lys Asn Leu Val Glu Glu Lys Asp Lys Lys
180 185 190
Ile Lys Glu Leu Gln Asp Asn Ile Ala Ala Val Thr Phe Thr Pro Gln
195 200 205
Ser Lys Asn Gly Lys Met Leu Met Ala Lys Cys Arg Thr Leu Gln Glu
210 215 220
Glu Asn Glu Glu Ile Gly His Gln Ala Ala Glu Gly Lys Ile His Glu
225 230 235 240
Leu Ala Ile Lys Leu Ala Met Gln Lys Ser Gln Asn Ala Glu Leu Arg
245 250 255
Ser Gln Phe Glu Gly Leu Tyr Lys His Met Glu Glu Leu Thr Asn Asp
260 265 270
Val Glu Arg Ser Asn Glu Thr Val Ile Ile Leu Gln Glu Lys Leu Glu
275 280 285
Glu Lys Glu Lys Glu Ile Glu Arg Val Lys Lys Gly Leu Glu Ile Val
290 295 300
Ser Glu Leu Val Gly Asp Lys Lys Asp Glu Val Asp Glu Ile Asp Glu
305 310 315 320
Asp Ala Lys Glu Glu Ile Ala Gly Gly Glu
325 330
<210> 7
<211> 191
<212> PRT
<213> Arabidopsis thaliana
<400> 7
Met Ala Asn Lys Phe Thr Arg Gln Gln Ile Ser Glu Phe Arg Glu Gln
1 5 10 15
Phe Ser Val Tyr Asp Lys Asn Gly Asp Gly His Ile Thr Thr Glu Glu
20 25 30
Phe Gly Ala Val Met Arg Ser Leu Gly Leu Asn Leu Thr Gln Ala Glu
35 40 45
Leu Gln Glu Glu Ile Asn Asp Ser Asp Leu Asp Gly Asp Gly Thr Ile
50 55 60
Asn Phe Thr Glu Phe Leu Cys Ala Met Ala Lys Asp Thr Tyr Ser Glu
65 70 75 80
Lys Asp Leu Lys Lys Asp Phe Arg Leu Phe Asp Ile Asp Lys Asn Gly
85 90 95
Phe Ile Ser Ala Ala Glu Met Arg Tyr Val Arg Thr Ile Leu Arg Trp
100 105 110
Lys Gln Thr Asp Glu Glu Ile Asp Glu Ile Ile Lys Ala Ala Asp Val
115 120 125
Asp Gly Asp Gly Gln Ile Asn Tyr Arg Glu Phe Ala Arg Leu Met Met
130 135 140
Ala Lys Asn Gln Gly His Asp Thr Lys Tyr Asp Thr Thr Gly Gly Thr
145 150 155 160
Leu Glu Arg Asp Leu Ala Ala Gly Val Ala Lys Asn Ile Ile Ala Ala
165 170 175
Pro Met Thr Asp Phe Ile Lys Asn Leu Phe Glu Ala Leu Phe Ser
180 185 190
<210> 8
<211> 671
<212> PRT
<213> Arabidopsis thaliana
<400> 8
Met Pro Leu Ile His Arg Lys Lys Pro Thr Glu Lys Pro Ser Thr Pro
1 5 10 15
Pro Ser Glu Glu Val Val His Asp Glu Asp Ser Gln Lys Lys Pro His
20 25 30
Glu Ser Ser Lys Ser His His Lys Lys Ser Asn Gly Gly Gly Lys Trp
35 40 45
Ser Cys Ile Asp Ser Cys Cys Trp Phe Ile Gly Cys Val Cys Val Thr
50 55 60
Trp Trp Phe Leu Leu Phe Leu Tyr Asn Ala Met Pro Ala Ser Phe Pro
65 70 75 80
Gln Tyr Val Thr Glu Arg Ile Thr Gly Pro Leu Pro Asp Pro Pro Gly
85 90 95
Val Lys Leu Lys Lys Glu Gly Leu Lys Ala Lys His Pro Val Val Phe
100 105 110
Ile Pro Gly Ile Val Thr Gly Gly Leu Glu Leu Trp Glu Gly Lys Gln
115 120 125
Cys Ala Asp Gly Leu Phe Arg Lys Arg Leu Trp Gly Gly Thr Phe Gly
130 135 140
Glu Val Tyr Lys Arg Pro Leu Cys Trp Val Glu His Met Ser Leu Asp
145 150 155 160
Asn Glu Thr Gly Leu Asp Pro Ala Gly Ile Arg Val Arg Ala Val Ser
165 170 175
Gly Leu Val Ala Ala Asp Tyr Phe Ala Pro Gly Tyr Phe Val Trp Ala
180 185 190
Val Leu Ile Ala Asn Leu Ala His Ile Gly Tyr Glu Glu Lys Asn Met
195 200 205
Tyr Met Ala Ala Tyr Asp Trp Arg Leu Ser Phe Gln Asn Thr Glu Val
210 215 220
Arg Asp Gln Thr Leu Ser Arg Met Lys Ser Asn Ile Glu Leu Met Val
225 230 235 240
Ser Thr Asn Gly Gly Lys Lys Ala Val Ile Val Pro His Ser Met Gly
245 250 255
Val Leu Tyr Phe Leu His Phe Met Lys Trp Val Glu Ala Pro Ala Pro
260 265 270
Leu Gly Gly Gly Gly Gly Pro Asp Trp Cys Ala Lys Tyr Ile Lys Ala
275 280 285
Val Met Asn Ile Gly Gly Pro Phe Leu Gly Val Pro Lys Ala Val Ala
290 295 300
Gly Leu Phe Ser Ala Glu Ala Lys Asp Val Ala Val Ala Arg Ala Ile
305 310 315 320
Ala Pro Gly Phe Leu Asp Thr Asp Ile Phe Arg Leu Gln Thr Leu Gln
325 330 335
His Val Met Arg Met Thr Arg Thr Trp Asp Ser Thr Met Ser Met Leu
340 345 350
Pro Lys Gly Gly Asp Thr Ile Trp Gly Gly Leu Asp Trp Ser Pro Glu
355 360 365
Lys Gly His Thr Cys Cys Gly Lys Lys Gln Lys Asn Asn Glu Thr Cys
370 375 380
Gly Glu Ala Gly Glu Asn Gly Val Ser Lys Lys Ser Pro Val Asn Tyr
385 390 395 400
Gly Arg Met Ile Ser Phe Gly Lys Glu Val Ala Glu Ala Ala Pro Ser
405 410 415
Glu Ile Asn Asn Ile Asp Phe Arg Gly Ala Val Lys Gly Gln Ser Ile
420 425 430
Pro Asn His Thr Cys Arg Asp Val Trp Thr Glu Tyr His Asp Met Gly
435 440 445
Ile Ala Gly Ile Lys Ala Ile Ala Glu Tyr Lys Val Tyr Thr Ala Gly
450 455 460
Glu Ala Ile Asp Leu Leu His Tyr Val Ala Pro Lys Met Met Ala Arg
465 470 475 480
Gly Ala Ala His Phe Ser Tyr Gly Ile Ala Asp Asp Leu Asp Asp Thr
485 490 495
Lys Tyr Gln Asp Pro Lys Tyr Trp Ser Asn Pro Leu Glu Thr Lys Leu
500 505 510
Pro Asn Ala Pro Glu Met Glu Ile Tyr Ser Leu Tyr Gly Val Gly Ile
515 520 525
Pro Thr Glu Arg Ala Tyr Val Tyr Lys Leu Asn Gln Ser Pro Asp Ser
530 535 540
Cys Ile Pro Phe Gln Ile Phe Thr Ser Ala His Glu Glu Asp Glu Asp
545 550 555 560
Ser Cys Leu Lys Ala Gly Val Tyr Asn Val Asp Gly Asp Glu Thr Val
565 570 575
Pro Val Leu Ser Ala Gly Tyr Met Cys Ala Lys Ala Trp Arg Gly Lys
580 585 590
Thr Arg Phe Asn Pro Ser Gly Ile Lys Thr Tyr Ile Arg Glu Tyr Asn
595 600 605
His Ser Pro Pro Ala Asn Leu Leu Glu Gly Arg Gly Thr Gln Ser Gly
610 615 620
Ala His Val Asp Ile Met Gly Asn Phe Ala Leu Ile Glu Asp Ile Met
625 630 635 640
Arg Val Ala Ala Gly Gly Asn Gly Ser Asp Ile Gly His Asp Gln Val
645 650 655
His Ser Gly Ile Phe Glu Trp Ser Glu Arg Ile Asp Leu Lys Leu
660 665 670
<210> 9
<211> 960
<212> PRT
<213> Arabidopsis thaliana
<400> 9
Met Ser Thr Ser His His His His His Pro Pro Tyr Leu Ile Thr Thr
1 5 10 15
Leu Phe Phe Leu Phe Leu Asn Phe Ser Cys Leu His Ala Asn Glu Leu
20 25 30
Glu Leu Leu Leu Ser Phe Lys Ser Ser Ile Gln Asp Pro Leu Lys His
35 40 45
Leu Ser Ser Trp Ser Tyr Ser Ser Thr Asn Asp Val Cys Leu Trp Ser
50 55 60
Gly Val Val Cys Asn Asn Ile Ser Arg Val Val Ser Leu Asp Leu Ser
65 70 75 80
Gly Lys Asn Met Ser Gly Gln Ile Leu Thr Ala Ala Thr Phe Arg Leu
85 90 95
Pro Phe Leu Gln Thr Ile Asn Leu Ser Asn Asn Asn Leu Ser Gly Pro
100 105 110
Ile Pro His Asp Ile Phe Thr Thr Ser Ser Pro Ser Leu Arg Tyr Leu
115 120 125
Asn Leu Ser Asn Asn Asn Phe Ser Gly Ser Ile Pro Arg Gly Phe Leu
130 135 140
Pro Asn Leu Tyr Thr Leu Asp Leu Ser Asn Asn Met Phe Thr Gly Glu
145 150 155 160
Ile Tyr Asn Asp Ile Gly Val Phe Ser Asn Leu Arg Val Leu Asp Leu
165 170 175
Gly Gly Asn Val Leu Thr Gly His Val Pro Gly Tyr Leu Gly Asn Leu
180 185 190
Ser Arg Leu Glu Phe Leu Thr Leu Ala Ser Asn Gln Leu Thr Gly Gly
195 200 205
Val Pro Val Glu Leu Gly Lys Met Lys Asn Leu Lys Trp Ile Tyr Leu
210 215 220
Gly Tyr Asn Asn Leu Ser Gly Glu Ile Pro Tyr Gln Ile Gly Gly Leu
225 230 235 240
Ser Ser Leu Asn His Leu Asp Leu Val Tyr Asn Asn Leu Ser Gly Pro
245 250 255
Ile Pro Pro Ser Leu Gly Asp Leu Lys Lys Leu Glu Tyr Met Phe Leu
260 265 270
Tyr Gln Asn Lys Leu Ser Gly Gln Ile Pro Pro Ser Ile Phe Ser Leu
275 280 285
Gln Asn Leu Ile Ser Leu Asp Phe Ser Asp Asn Ser Leu Ser Gly Glu
290 295 300
Ile Pro Glu Leu Val Ala Gln Met Gln Ser Leu Glu Ile Leu His Leu
305 310 315 320
Phe Ser Asn Asn Leu Thr Gly Lys Ile Pro Glu Gly Val Thr Ser Leu
325 330 335
Pro Arg Leu Lys Val Leu Gln Leu Trp Ser Asn Arg Phe Ser Gly Gly
340 345 350
Ile Pro Ala Asn Leu Gly Lys His Asn Asn Leu Thr Val Leu Asp Leu
355 360 365
Ser Thr Asn Asn Leu Thr Gly Lys Leu Pro Asp Thr Leu Cys Asp Ser
370 375 380
Gly His Leu Thr Lys Leu Ile Leu Phe Ser Asn Ser Leu Asp Ser Gln
385 390 395 400
Ile Pro Pro Ser Leu Gly Met Cys Gln Ser Leu Glu Arg Val Arg Leu
405 410 415
Gln Asn Asn Gly Phe Ser Gly Lys Leu Pro Arg Gly Phe Thr Lys Leu
420 425 430
Gln Leu Val Asn Phe Leu Asp Leu Ser Asn Asn Asn Leu Gln Gly Asn
435 440 445
Ile Asn Thr Trp Asp Met Pro Gln Leu Glu Met Leu Asp Leu Ser Val
450 455 460
Asn Lys Phe Phe Gly Glu Leu Pro Asp Phe Ser Arg Ser Lys Arg Leu
465 470 475 480
Lys Lys Leu Asp Leu Ser Arg Asn Lys Ile Ser Gly Val Val Pro Gln
485 490 495
Gly Leu Met Thr Phe Pro Glu Ile Met Asp Leu Asp Leu Ser Glu Asn
500 505 510
Glu Ile Thr Gly Val Ile Pro Arg Glu Leu Ser Ser Cys Lys Asn Leu
515 520 525
Val Asn Leu Asp Leu Ser His Asn Asn Phe Thr Gly Glu Ile Pro Ser
530 535 540
Ser Phe Ala Glu Phe Gln Val Leu Ser Asp Leu Asp Leu Ser Cys Asn
545 550 555 560
Gln Leu Ser Gly Glu Ile Pro Lys Asn Leu Gly Asn Ile Glu Ser Leu
565 570 575
Val Gln Val Asn Ile Ser His Asn Leu Leu His Gly Ser Leu Pro Phe
580 585 590
Thr Gly Ala Phe Leu Ala Ile Asn Ala Thr Ala Val Glu Gly Asn Ile
595 600 605
Asp Leu Cys Ser Glu Asn Ser Ala Ser Gly Leu Arg Pro Cys Lys Val
610 615 620
Val Arg Lys Arg Ser Thr Lys Ser Trp Trp Leu Ile Ile Thr Ser Thr
625 630 635 640
Phe Ala Ala Phe Leu Ala Val Leu Val Ser Gly Phe Phe Ile Val Leu
645 650 655
Val Phe Gln Arg Thr His Asn Val Leu Glu Val Lys Lys Val Glu Gln
660 665 670
Glu Asp Gly Thr Lys Trp Glu Thr Gln Phe Phe Asp Ser Lys Phe Met
675 680 685
Lys Ser Phe Thr Val Asn Thr Ile Leu Ser Ser Leu Lys Asp Gln Asn
690 695 700
Val Leu Val Asp Lys Asn Gly Val His Phe Val Val Lys Glu Val Lys
705 710 715 720
Lys Tyr Asp Ser Leu Pro Glu Met Ile Ser Asp Met Arg Lys Leu Ser
725 730 735
Asp His Lys Asn Ile Leu Lys Ile Val Ala Thr Cys Arg Ser Glu Thr
740 745 750
Val Ala Tyr Leu Ile His Glu Asp Val Glu Gly Lys Arg Leu Ser Gln
755 760 765
Val Leu Ser Gly Leu Ser Trp Glu Arg Arg Arg Lys Ile Met Lys Gly
770 775 780
Ile Val Glu Ala Leu Arg Phe Leu His Cys Arg Cys Ser Pro Ala Val
785 790 795 800
Val Ala Gly Asn Leu Ser Pro Glu Asn Ile Val Ile Asp Val Thr Asp
805 810 815
Glu Pro Arg Leu Cys Leu Gly Leu Pro Gly Leu Leu Cys Met Asp Ala
820 825 830
Ala Tyr Met Ala Pro Glu Thr Arg Glu His Lys Glu Met Thr Ser Lys
835 840 845
Ser Asp Ile Tyr Gly Phe Gly Ile Leu Leu Leu His Leu Leu Thr Gly
850 855 860
Lys Cys Ser Ser Ser Asn Glu Asp Ile Glu Ser Gly Val Asn Gly Ser
865 870 875 880
Leu Val Lys Trp Ala Arg Tyr Ser Tyr Ser Asn Cys His Ile Asp Thr
885 890 895
Trp Ile Asp Ser Ser Ile Asp Thr Ser Val His Gln Arg Glu Ile Val
900 905 910
His Val Met Asn Leu Ala Leu Lys Cys Thr Ala Ile Asp Pro Gln Glu
915 920 925
Arg Pro Cys Thr Asn Asn Val Leu Gln Ala Leu Glu Ser Thr Ser Ser
930 935 940
Ser Ser Ser Ser Cys Thr Thr Tyr Leu Ser Lys Ile Leu Ser Leu Ala
945 950 955 960
<210> 10
<211> 1090
<212> PRT
<213> Arabidopsis thaliana
<400> 10
Met Pro Arg Asn Pro Arg Phe Cys Phe Phe Leu Phe Leu Leu Phe His
1 5 10 15
Ser Ser Leu Phe Phe Ser Ile Pro Cys Phe Ser Ile Asp Glu Gln Gly
20 25 30
Leu Ala Leu Leu Ser Trp Lys Ser Gln Leu Asn Ile Ser Gly Asp Ala
35 40 45
Leu Ser Ser Trp Lys Ala Ser Glu Ser Asn Pro Cys Gln Trp Val Gly
50 55 60
Ile Lys Cys Asn Glu Arg Gly Gln Val Ser Glu Ile Gln Leu Gln Val
65 70 75 80
Met Asp Phe Gln Gly Pro Leu Pro Ala Thr Asn Leu Arg Gln Ile Lys
85 90 95
Ser Leu Thr Leu Leu Ser Leu Thr Ser Val Asn Leu Thr Gly Ser Ile
100 105 110
Pro Lys Glu Leu Gly Asp Leu Ser Glu Leu Glu Val Leu Asp Leu Ala
115 120 125
Asp Asn Ser Leu Ser Gly Glu Ile Pro Val Asp Ile Phe Lys Leu Lys
130 135 140
Lys Leu Lys Ile Leu Ser Leu Asn Thr Asn Asn Leu Glu Gly Val Ile
145 150 155 160
Pro Ser Glu Leu Gly Asn Leu Val Asn Leu Ile Glu Leu Thr Leu Phe
165 170 175
Asp Asn Lys Leu Ala Gly Glu Ile Pro Arg Thr Ile Gly Glu Leu Lys
180 185 190
Asn Leu Glu Ile Phe Arg Ala Gly Gly Asn Lys Asn Leu Arg Gly Glu
195 200 205
Leu Pro Trp Glu Ile Gly Asn Cys Glu Ser Leu Val Thr Leu Gly Leu
210 215 220
Ala Glu Thr Ser Leu Ser Gly Arg Leu Pro Ala Ser Ile Gly Asn Leu
225 230 235 240
Lys Lys Val Gln Thr Ile Ala Leu Tyr Thr Ser Leu Leu Ser Gly Pro
245 250 255
Ile Pro Asp Glu Ile Gly Asn Cys Thr Glu Leu Gln Asn Leu Tyr Leu
260 265 270
Tyr Gln Asn Ser Ile Ser Gly Ser Ile Pro Val Ser Met Gly Arg Leu
275 280 285
Lys Lys Leu Gln Ser Leu Leu Leu Trp Gln Asn Asn Leu Val Gly Lys
290 295 300
Ile Pro Thr Glu Leu Gly Thr Cys Pro Glu Leu Phe Leu Val Asp Leu
305 310 315 320
Ser Glu Asn Leu Leu Thr Gly Asn Ile Pro Arg Ser Phe Gly Asn Leu
325 330 335
Pro Asn Leu Gln Glu Leu Gln Leu Ser Val Asn Gln Leu Ser Gly Thr
340 345 350
Ile Pro Glu Glu Leu Ala Asn Cys Thr Lys Leu Thr His Leu Glu Ile
355 360 365
Asp Asn Asn Gln Ile Ser Gly Glu Ile Pro Pro Leu Ile Gly Lys Leu
370 375 380
Thr Ser Leu Thr Met Phe Phe Ala Trp Gln Asn Gln Leu Thr Gly Ile
385 390 395 400
Ile Pro Glu Ser Leu Ser Gln Cys Gln Glu Leu Gln Ala Ile Asp Leu
405 410 415
Ser Tyr Asn Asn Leu Ser Gly Ser Ile Pro Asn Gly Ile Phe Glu Ile
420 425 430
Arg Asn Leu Thr Lys Leu Leu Leu Leu Ser Asn Tyr Leu Ser Gly Phe
435 440 445
Ile Pro Pro Asp Ile Gly Asn Cys Thr Asn Leu Tyr Arg Leu Arg Leu
450 455 460
Asn Gly Asn Arg Leu Ala Gly Asn Ile Pro Ala Glu Ile Gly Asn Leu
465 470 475 480
Lys Asn Leu Asn Phe Ile Asp Ile Ser Glu Asn Arg Leu Ile Gly Asn
485 490 495
Ile Pro Pro Glu Ile Ser Gly Cys Thr Ser Leu Glu Phe Val Asp Leu
500 505 510
His Ser Asn Gly Leu Thr Gly Gly Leu Pro Gly Thr Leu Pro Lys Ser
515 520 525
Leu Gln Phe Ile Asp Leu Ser Asp Asn Ser Leu Thr Gly Ser Leu Pro
530 535 540
Thr Gly Ile Gly Ser Leu Thr Glu Leu Thr Lys Leu Asn Leu Ala Lys
545 550 555 560
Asn Arg Phe Ser Gly Glu Ile Pro Arg Glu Ile Ser Ser Cys Arg Ser
565 570 575
Leu Gln Leu Leu Asn Leu Gly Asp Asn Gly Phe Thr Gly Glu Ile Pro
580 585 590
Asn Glu Leu Gly Arg Ile Pro Ser Leu Ala Ile Ser Leu Asn Leu Ser
595 600 605
Cys Asn His Phe Thr Gly Glu Ile Pro Ser Arg Phe Ser Ser Leu Thr
610 615 620
Asn Leu Gly Thr Leu Asp Val Ser His Asn Lys Leu Ala Gly Asn Leu
625 630 635 640
Asn Val Leu Ala Asp Leu Gln Asn Leu Val Ser Leu Asn Ile Ser Phe
645 650 655
Asn Glu Phe Ser Gly Glu Leu Pro Asn Thr Leu Phe Phe Arg Lys Leu
660 665 670
Pro Leu Ser Val Leu Glu Ser Asn Lys Gly Leu Phe Ile Ser Thr Arg
675 680 685
Pro Glu Asn Gly Ile Gln Thr Arg His Arg Ser Ala Val Lys Val Thr
690 695 700
Met Ser Ile Leu Val Ala Ala Ser Val Val Leu Val Leu Met Ala Val
705 710 715 720
Tyr Thr Leu Val Lys Ala Gln Arg Ile Thr Gly Lys Gln Glu Glu Leu
725 730 735
Asp Ser Trp Glu Val Thr Leu Tyr Gln Lys Leu Asp Phe Ser Ile Asp
740 745 750
Asp Ile Val Lys Asn Leu Thr Ser Ala Asn Val Ile Gly Thr Gly Ser
755 760 765
Ser Gly Val Val Tyr Arg Val Thr Ile Pro Ser Gly Glu Thr Leu Ala
770 775 780
Val Lys Lys Met Trp Ser Lys Glu Glu Asn Arg Ala Phe Asn Ser Glu
785 790 795 800
Ile Asn Thr Leu Gly Ser Ile Arg His Arg Asn Ile Ile Arg Leu Leu
805 810 815
Gly Trp Cys Ser Asn Arg Asn Leu Lys Leu Leu Phe Tyr Asp Tyr Leu
820 825 830
Pro Asn Gly Ser Leu Ser Ser Leu Leu His Gly Ala Gly Lys Gly Ser
835 840 845
Gly Gly Ala Asp Trp Glu Ala Arg Tyr Asp Val Val Leu Gly Val Ala
850 855 860
His Ala Leu Ala Tyr Leu His His Asp Cys Leu Pro Pro Ile Leu His
865 870 875 880
Gly Asp Val Lys Ala Met Asn Val Leu Leu Gly Ser Arg Phe Glu Ser
885 890 895
Tyr Leu Ala Asp Phe Gly Leu Ala Lys Ile Val Ser Gly Glu Gly Val
900 905 910
Thr Asp Gly Asp Ser Ser Lys Leu Ser Asn Arg Pro Pro Leu Ala Gly
915 920 925
Ser Tyr Gly Tyr Met Ala Pro Glu His Ala Ser Met Gln His Ile Thr
930 935 940
Glu Lys Ser Asp Val Tyr Ser Tyr Gly Val Val Leu Leu Glu Val Leu
945 950 955 960
Thr Gly Lys His Pro Leu Asp Pro Asp Leu Pro Gly Gly Ala His Leu
965 970 975
Val Gln Trp Val Arg Asp His Leu Ala Gly Lys Lys Asp Pro Arg Glu
980 985 990
Ile Leu Asp Pro Arg Leu Arg Gly Arg Ala Asp Pro Ile Met His Glu
995 1000 1005
Met Leu Gln Thr Leu Ala Val Ser Phe Leu Cys Val Ser Asn Lys Ala
1010 1015 1020
Ser Asp Arg Pro Met Met Lys Asp Ile Val Ala Met Leu Lys Glu Ile
1025 1030 1035 1040
Arg Gln Phe Asp Met Asp Arg Ser Glu Ser Asp Met Ile Lys Gly Gly
1045 1050 1055
Lys Cys Glu Lys Trp Gln Pro Gln Pro Leu Pro Pro Glu Lys Ile Val
1060 1065 1070
Ser Thr Pro Arg Gly Ser Ser Asn Cys Ser Phe Ala Tyr Ser Asp Glu
1075 1080 1085
Ser Val
1090
<210> 11
<211> 681
<212> PRT
<213> Arabidopsis thaliana
<400> 11
Met Ser Gly Ser Val Ser Gly Cys Gly Ser Gly Gly Cys Ser Ile Val
1 5 10 15
Trp Phe Arg Arg Asp Leu Arg Val Glu Asp Asn Pro Ala Leu Ala Ala
20 25 30
Ala Val Arg Ala Gly Pro Val Ile Ala Leu Phe Val Trp Ala Pro Glu
35 40 45
Glu Glu Gly His Tyr His Pro Gly Arg Val Ser Arg Trp Trp Leu Lys
50 55 60
Asn Ser Leu Ala Gln Leu Asp Ser Ser Leu Arg Ser Leu Gly Thr Cys
65 70 75 80
Leu Ile Thr Lys Arg Ser Thr Asp Ser Val Ala Ser Leu Leu Asp Val
85 90 95
Val Lys Ser Thr Gly Ala Ser Gln Ile Phe Phe Asn His Leu Tyr Asp
100 105 110
Pro Leu Ser Leu Val Arg Asp His Arg Ala Lys Asp Val Leu Thr Ala
115 120 125
Gln Gly Ile Ala Val Arg Ser Phe Asn Ala Asp Leu Leu Tyr Glu Pro
130 135 140
Trp Glu Val Thr Asp Glu Leu Gly Arg Pro Phe Ser Met Phe Ala Ala
145 150 155 160
Phe Trp Glu Arg Cys Leu Ser Met Pro Tyr Asp Pro Glu Ser Pro Leu
165 170 175
Leu Pro Pro Lys Lys Ile Ile Ser Gly Asp Val Ser Lys Cys Val Ala
180 185 190
Asp Pro Leu Val Phe Glu Asp Asp Ser Glu Lys Gly Ser Asn Ala Leu
195 200 205
Leu Ala Arg Ala Trp Ser Pro Gly Trp Ser Asn Gly Asp Lys Ala Leu
210 215 220
Thr Thr Phe Ile Asn Gly Pro Leu Leu Glu Tyr Ser Lys Asn Arg Arg
225 230 235 240
Lys Ala Asp Ser Ala Thr Thr Ser Phe Leu Ser Pro His Leu His Phe
245 250 255
Gly Glu Val Ser Val Arg Lys Val Phe His Leu Val Arg Ile Lys Gln
260 265 270
Val Ala Trp Ala Asn Glu Gly Asn Glu Ala Gly Glu Glu Ser Val Asn
275 280 285
Leu Phe Leu Lys Ser Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Ser
290 295 300
Phe Asn His Pro Tyr Ser His Glu Arg Pro Leu Leu Gly His Leu Lys
305 310 315 320
Phe Phe Pro Trp Ala Val Asp Glu Asn Tyr Phe Lys Ala Trp Arg Gln
325 330 335
Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp
340 345 350
Ala Thr Gly Trp Leu His Asp Arg Ile Arg Val Val Val Ser Ser Phe
355 360 365
Phe Val Lys Val Leu Gln Leu Pro Trp Arg Trp Gly Met Lys Tyr Phe
370 375 380
Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Ser Asp Ala Leu Gly Trp
385 390 395 400
Gln Tyr Ile Thr Gly Thr Leu Pro Asp Ser Arg Glu Phe Asp Arg Ile
405 410 415
Asp Asn Pro Gln Phe Glu Gly Tyr Lys Phe Asp Pro Asn Gly Glu Tyr
420 425 430
Val Arg Arg Trp Leu Pro Glu Leu Ser Arg Leu Pro Thr Asp Trp Ile
435 440 445
His His Pro Trp Asn Ala Pro Glu Ser Val Leu Gln Ala Ala Gly Ile
450 455 460
Glu Leu Gly Ser Asn Tyr Pro Leu Pro Ile Val Gly Leu Asp Glu Ala
465 470 475 480
Lys Ala Arg Leu His Glu Ala Leu Ser Gln Met Trp Gln Leu Glu Ala
485 490 495
Ala Ser Arg Ala Ala Ile Glu Asn Gly Ser Glu Glu Gly Leu Gly Asp
500 505 510
Ser Ala Glu Val Glu Glu Ala Pro Ile Glu Phe Pro Arg Asp Ile Thr
515 520 525
Met Glu Glu Thr Glu Pro Thr Arg Leu Asn Pro Asn Arg Arg Tyr Glu
530 535 540
Asp Gln Met Val Pro Ser Ile Thr Ser Ser Leu Ile Arg Pro Glu Glu
545 550 555 560
Asp Glu Glu Ser Ser Leu Asn Leu Arg Asn Ser Val Gly Asp Ser Arg
565 570 575
Ala Glu Val Pro Arg Asn Met Val Asn Thr Asn Gln Ala Gln Gln Arg
580 585 590
Arg Ala Glu Pro Ala Ser Asn Gln Val Thr Ala Met Ile Pro Glu Phe
595 600 605
Asn Ile Arg Ile Val Ala Glu Ser Thr Glu Asp Ser Thr Ala Glu Ser
610 615 620
Ser Ser Ser Gly Arg Arg Glu Arg Ser Gly Gly Ile Val Pro Glu Trp
625 630 635 640
Ser Pro Gly Tyr Ser Glu Gln Phe Pro Ser Glu Glu Asn Gly Ile Gly
645 650 655
Gly Gly Ser Thr Thr Ser Ser Tyr Leu Gln Asn His His Glu Ile Leu
660 665 670
Asn Trp Arg Arg Leu Ser Gln Thr Gly
675 680
<210> 12
<211> 1500
<212> PRT
<213> Arabidopsis thaliana
<400> 12
Met Glu Glu Asn Arg Arg Asn Pro Ser Ala Gly Met Glu Val Pro Val
1 5 10 15
Ala Gly Gly Gly Asn Val Val Lys Trp Ile Glu Ile Ser Val Pro Ser
20 25 30
Pro Ser Val Ser Ser Ser Ser Ile Gly Ala Asn Ser Ser Glu Asp Asn
35 40 45
Glu Cys Val Gln Leu Pro Leu Ser Glu Asp Tyr Ala Ser Ser Ser Val
50 55 60
Ile Gly Glu Pro Ser Ile Ser Phe Val Trp Arg Ile Asn Lys Thr Ser
65 70 75 80
Pro Asn Ala Leu Glu Leu Leu Gln Leu Ser Ala Lys Ser Gly Phe Pro
85 90 95
Ile Thr Gly Leu Arg Phe Val Phe Ala Gln Thr Leu Ser Pro Phe Ala
100 105 110
Phe Val Tyr Ala Asp Glu Gly Gly Asp Ser Gly Arg Leu Val Tyr Phe
115 120 125
Leu Tyr Ser Leu Thr Pro Ser Gly Val Val Tyr Val Leu Lys Leu Ser
130 135 140
Asn Thr Leu Ala Tyr Lys Ser Gly Ser Val Phe Pro Leu Asp His Leu
145 150 155 160
Ile His Leu Asp Val Arg Pro Tyr Leu Asn Glu Ser Arg Val Thr Ser
165 170 175
Val Ala Ala Ser Pro Gly Phe Ile Phe Leu Gly Arg Ser Asp Gly Cys
180 185 190
Val Ser Cys Phe Gln Pro Ile Val Tyr Phe Gln Lys Ser Ser Gly Phe
195 200 205
His Gln Glu Leu Arg Asp Asp Thr Gly Phe Gly Arg Leu Trp Gly Phe
210 215 220
Val Arg Gly Thr Val Val Ala Ala Val Gln Asp Leu Phe Ile Ser Glu
225 230 235 240
Val His Gly Arg Asn Tyr Leu Cys Val Leu His Ala Asp Gly Ala Leu
245 250 255
Arg Val Trp Asp Ile Leu Thr Tyr Ser Arg Val Leu Cys Gln Ser Ile
260 265 270
Ala Ala Lys Asn Leu Glu Gly Val Met Cys Val Arg Leu Trp Leu Gly
275 280 285
Lys Ala Asp Tyr Asp Ser Gly Ile Ile Pro Leu Ala Val Leu Tyr Arg
290 295 300
Lys Ser Met Asn Asp Ser Met Asp Val Ile Thr Val Tyr Gly Leu His
305 310 315 320
Phe Ser Ser Ala Glu Gly Ile Ala Leu Ser Leu Asp Ser Gly Leu Gln
325 330 335
Asn Ile Pro Leu Glu Glu Gly Glu Leu Arg Asp Val Arg Phe Thr Ser
340 345 350
Asp Lys Ile Trp Thr Leu Lys Ala Asn Glu Leu Thr Ser Tyr Met Leu
355 360 365
Cys Gln Lys Ser Ser Thr Met Glu Ala Gln Ser Tyr Thr Leu Gln Glu
370 375 380
Asp Tyr Ile Ser Glu Gln Leu Phe Leu Ser Ser Arg Ser Ser Ser His
385 390 395 400
Asp Leu Leu Leu Thr Thr His Ser Leu Phe Ser Ser Ala Lys Asp Gln
405 410 415
Ile Met Gly Phe Ile Ser Ser Ile Phe Leu Arg Arg Leu Leu Cys Pro
420 425 430
Gly Ile Phe His Asn Val Ala Leu Arg Leu Thr Leu Leu Asp His Asn
435 440 445
Lys Asn Trp Thr Asp Ser Glu Phe Gln Ser Leu Ser Leu Asp Glu Leu
450 455 460
Thr Ser Glu Ile Leu Leu Leu Val Glu His Glu Val Thr Ala Glu Thr
465 470 475 480
Ser Ile Ser Val Phe His Trp Trp Lys Asn Phe Cys Thr Ser Tyr Leu
485 490 495
His His Trp Cys Ser Asn Asn Glu Pro Arg Thr Leu Leu Val Gln Ser
500 505 510
Asp Val Ile Gly Leu Val Arg Asn Asn Ser Val Ser Leu Phe Phe Arg
515 520 525
Leu Glu Asn Ala Glu His Ser Leu Gly Gly Ser Ser Ser Glu His Ser
530 535 540
Asn Leu Thr Ser Leu Asp Leu Gly Val Ser His Ser Asp His Glu Ile
545 550 555 560
Leu Ala Glu Val Leu Arg Cys Thr Ser Lys Ile Ser Lys Gln Trp Gly
565 570 575
Gly Ala Pro Tyr Ala Met Tyr Tyr Glu Ser Ile Thr Gly Arg Pro Ile
580 585 590
Ile Ser Ser Asp Glu Ile Val Pro Arg Leu Val Asn Ile Leu Glu Ser
595 600 605
Gly Tyr Ser Thr Thr Ile Gly Gln Arg Thr Trp Ser Asp Leu Gly Ala
610 615 620
Asp Arg Ala Trp Glu Lys Glu Leu Glu Ala His Lys Asn Leu Arg Thr
625 630 635 640
Phe Ser Ile Asp Met Leu Leu Ser Leu Ser Ala Leu Cys Gln Arg Ala
645 650 655
Gly Ser Trp Glu Lys Val Phe Thr Ile Met Glu His Tyr Leu Gln Tyr
660 665 670
Leu Val Pro Lys Lys Ser Met Gln Lys Asn Asp Gly Glu Ala Leu Ser
675 680 685
Asp Ile Cys Ser Ser Ile Leu Val Gln Ala Thr Ser Gln Phe Val Lys
690 695 700
Val Met Phe Glu Ser Ala Phe Asp Ile Phe Leu Leu Ile Ser Tyr Leu
705 710 715 720
Leu Asn Ile Ala Gly Gln Val Asn Met Ser Gln Gln Asp Ile Cys Lys
725 730 735
Leu Arg Leu Glu Leu Leu Pro Met Ile Gln Asp Ile Val Ser Glu Trp
740 745 750
Leu Ile Ile Leu Phe Phe Val Thr Thr Pro Ala Glu Ser Thr Ser Met
755 760 765
Glu Asp Phe Ser Leu Lys Leu Ser Ser Leu Gln Ile Asp Ser Ser Ile
770 775 780
Asp Lys Arg Ser Trp Asn Ala Met Leu Gly Lys Cys Gly Phe Ser Leu
785 790 795 800
Ala Phe Ile Leu Leu Phe Ser Asp Arg Ser Cys Ile Val Asp Gly Arg
805 810 815
Phe Asn Leu Arg Tyr Leu Pro Ser Ser Gln Ile Ile Thr Ser Leu Val
820 825 830
Gln Asn Phe Ile Ser Trp Ile Arg Tyr Ser Lys Thr Gly Asp Asp Ser
835 840 845
Ser Ser Leu Leu Arg Arg Ser Thr Glu Leu Ser Leu Arg Leu Ile Arg
850 855 860
Asn Gly Gln Ser Asp Ala Val Glu Arg Ile Leu Val Val Val Glu Ala
865 870 875 880
Ser Leu Arg Gly Glu Lys Thr Phe Gly Cys Ser Gln Asp Thr Ser Gly
885 890 895
Asp Trp Cys Leu Leu Gln His Leu Arg Gly Cys Cys Leu Leu Asp Gln
900 905 910
Val Gln Arg Gly Ala Ser Gly Ile Leu Arg Glu Arg Lys Ile Ile Asp
915 920 925
Ala Ile Arg Cys Phe Phe Arg Ala Ser Ser Gly Glu Gly Ser Trp Lys
930 935 940
Ala Leu His Ser Leu Ser Lys Glu Ala Gly Phe Ser Pro Ala Thr Thr
945 950 955 960
Gly Pro Ser Ile Leu Asp Gly Ser Thr Ser Ser Ala Ala Trp Lys Leu
965 970 975
His Tyr Tyr Glu Trp Ala Met Gln Ile Phe Glu Arg Tyr Asn Ile Ser
980 985 990
Glu Gly Ala Cys Gln Phe Ala Tyr Ala Ala Leu Glu Gln Val Asp Asp
995 1000 1005
Ala Tyr Asn Phe Ile Glu Met Thr Glu Glu Phe Asp Pro Thr Lys Ala
1010 1015 1020
Ala Thr Tyr Thr Arg Gly Arg Leu Trp Ala Asn Val Phe Lys Phe Thr
1025 1030 1035 1040
Leu Asp Leu Asn Leu Leu Asn Asp Ala Tyr Cys Ala Ile Ile Ser Asn
1045 1050 1055
Pro Asp Glu Glu Ile Lys Arg Ile Cys Leu Arg Arg Phe Ile Ile Val
1060 1065 1070
Leu Phe Glu Cys Gly Lys Thr Lys Ile Leu Ser Asp Gly His Leu Pro
1075 1080 1085
Phe Ile Gly Leu Thr Glu Lys Ile Thr Gln Glu Leu Phe Trp Lys Ala
1090 1095 1100
Gly Arg Ser Asp Ile Met Met Lys Pro Asn Pro Tyr Lys Leu Leu Tyr
1105 1110 1115 1120
Ala Tyr Glu Met Arg Arg His Asn Trp Arg Met Ala Ala Ser Tyr Met
1125 1130 1135
Tyr Gln Phe Ser Ala Arg Leu Arg Ser Glu Gly Ala Cys Lys Asp Tyr
1140 1145 1150
Lys His Met Ser Leu Val Leu Gln Glu Arg Leu Asn Gly Leu Ser Ala
1155 1160 1165
Ala Met Asn Ala Leu Ala Leu Val His Pro Gly Tyr Ala Trp Ile Asp
1170 1175 1180
Pro Val Pro Glu Glu Thr Thr Arg Tyr Pro Val Lys Lys Ala Arg Arg
1185 1190 1195 1200
Ala Glu Glu Glu Gln Leu Arg Ser Asn Asp Gln Pro Lys Gly Glu Lys
1205 1210 1215
Ser Cys Ile Asp Ile Glu Lys Leu Gln Asn Glu Phe Val Phe Thr Thr
1220 1225 1230
Ala Glu Tyr Met Leu Ser Leu Lys Asn Phe Gly Trp Thr Tyr Ser Gly
1235 1240 1245
Leu Glu Lys Pro Pro Ser Asp Leu Val Asp Leu Leu Val Gln Ala Asn
1250 1255 1260
Leu Tyr Asp Met Ala Phe Thr Val Val Leu Lys Phe Trp Arg Gly Ser
1265 1270 1275 1280
Ala Leu Lys Arg Glu Leu Glu Lys Ile Phe Glu Asn Met Ala Ile Lys
1285 1290 1295
Cys Cys Pro Ala Lys Gly Thr Leu Trp Ser Ser Pro Asn Leu Met Leu
1300 1305 1310
Thr Ser Asn Asp Glu Glu Val Thr His Ser Pro Asp Arg Ser Pro Ala
1315 1320 1325
Asp Gln Gly Ser Lys Leu Ala Gly Asp Trp Glu Ile Leu Glu Val Tyr
1330 1335 1340
Leu Lys Arg Tyr Ile Asp Ile His Ala Arg Leu Pro Val Ser Val Ala
1345 1350 1355 1360
Ser Thr Leu Leu Gln Ala Asp Ser Cys Ile Glu Leu Pro Leu Trp Leu
1365 1370 1375
Ile Gln Met Phe Lys Asp Gly Gln Lys Glu Lys Ala Leu Gly Met Ala
1380 1385 1390
Gly Gln Glu Ala Ser Pro Ala Ser Leu Phe Gln Leu Tyr Val Asp Tyr
1395 1400 1405
Gly Arg Leu Thr Glu Ala Thr Asn Leu Leu Leu Glu Tyr Met Glu Ser
1410 1415 1420
Phe Ala Ser Ser Lys Pro Ala Glu Val Leu Lys Arg Lys Lys Val Ser
1425 1430 1435 1440
Gly Val Trp Phe Pro Tyr Thr Thr Val Glu Arg Leu Trp Trp Glu Leu
1445 1450 1455
Glu Lys Thr Met Asn Ser Gly Arg Met Val Glu Gln Cys His Lys Leu
1460 1465 1470
Lys Glu Gln Leu His His Ala Leu Leu Asn His Leu Lys Leu Leu Lys
1475 1480 1485
Val Asp Ser Asn Asp Ala Val Ser Ser Ala Thr Gly
1490 1495 1500
<210> 13
<211> 1041
<212> PRT
<213> Arabidopsis thaliana
<400> 13
Met Phe Gly Ser Ser Asn Pro Phe Gly Gln Ser Ser Gly Thr Ser Pro
1 5 10 15
Phe Gly Ser Gln Ser Leu Phe Gly Gln Thr Ser Asn Thr Ser Ser Asn
20 25 30
Asn Pro Phe Ala Pro Ala Thr Pro Phe Gly Thr Ser Ala Pro Phe Ala
35 40 45
Ala Gln Ser Gly Ser Ser Ile Phe Gly Ser Thr Ser Thr Gly Val Phe
50 55 60
Gly Ala Pro Gln Thr Ser Ser Pro Phe Ala Ser Thr Pro Thr Phe Gly
65 70 75 80
Ala Ser Ser Ser Pro Ala Phe Gly Asn Ser Thr Pro Ala Phe Gly Ala
85 90 95
Ser Pro Ala Ser Ser Pro Phe Gly Gly Ser Ser Gly Phe Gly Gln Lys
100 105 110
Pro Leu Gly Phe Ser Thr Pro Gln Ser Asn Pro Phe Gly Asn Ser Thr
115 120 125
Gln Gln Ser Gln Pro Ala Phe Gly Asn Thr Ser Phe Gly Ser Ser Thr
130 135 140
Pro Phe Gly Ala Thr Asn Thr Pro Ala Phe Gly Ala Pro Ser Thr Pro
145 150 155 160
Ser Phe Gly Ala Thr Ser Thr Pro Ser Phe Gly Ala Ser Ser Thr Pro
165 170 175
Ala Phe Gly Ala Thr Asn Thr Pro Ala Phe Gly Ala Ser Asn Ser Pro
180 185 190
Ser Phe Gly Ala Thr Asn Thr Pro Ala Phe Gly Ala Ser Pro Thr Pro
195 200 205
Ala Phe Gly Ser Thr Gly Thr Thr Phe Gly Asn Thr Gly Phe Gly Ser
210 215 220
Gly Gly Ala Phe Gly Ala Ser Asn Thr Pro Ala Phe Gly Ala Ser Gly
225 230 235 240
Thr Pro Ala Phe Gly Ala Ser Gly Thr Pro Ala Phe Gly Ala Ser Ser
245 250 255
Thr Pro Ala Phe Gly Ala Ser Ser Thr Pro Ala Phe Gly Ala Ser Ser
260 265 270
Thr Pro Ala Phe Gly Gly Ser Ser Thr Pro Ser Phe Gly Ala Ser Asn
275 280 285
Thr Ser Ser Phe Ser Phe Gly Ser Ser Pro Ala Phe Gly Gln Ser Thr
290 295 300
Ser Ala Phe Gly Ser Ser Ala Phe Gly Ser Thr Pro Ser Pro Phe Gly
305 310 315 320
Gly Ala Gln Ala Ser Thr Pro Thr Phe Gly Gly Ser Gly Phe Gly Gln
325 330 335
Ser Thr Phe Gly Gly Gln Gln Gly Gly Ser Arg Ala Val Pro Tyr Ala
340 345 350
Pro Thr Val Glu Ala Asp Thr Gly Thr Gly Thr Gln Pro Ala Gly Lys
355 360 365
Leu Glu Ser Ile Ser Ala Met Pro Ala Tyr Lys Glu Lys Asn Tyr Glu
370 375 380
Glu Leu Arg Trp Glu Asp Tyr Gln Arg Gly Asp Lys Gly Gly Pro Leu
385 390 395 400
Pro Ala Gly Gln Ser Pro Gly Asn Ala Gly Phe Gly Ile Ser Pro Ser
405 410 415
Gln Pro Asn Pro Phe Ser Pro Ser Pro Ala Phe Gly Gln Thr Ser Ala
420 425 430
Asn Pro Thr Asn Pro Phe Ser Ser Ser Thr Ser Thr Asn Pro Phe Ala
435 440 445
Pro Gln Thr Pro Thr Ile Ala Ser Ser Ser Phe Gly Thr Ala Thr Ser
450 455 460
Asn Phe Gly Ser Ser Pro Phe Gly Val Thr Ser Ser Ser Asn Leu Phe
465 470 475 480
Gly Ser Gly Ser Ser Thr Thr Thr Ser Val Phe Gly Ser Ser Ser Ala
485 490 495
Phe Gly Thr Thr Thr Pro Ser Pro Leu Phe Gly Ser Ser Ser Thr Pro
500 505 510
Gly Phe Gly Ser Ser Ser Ser Ile Phe Gly Ser Ala Pro Gly Gln Gly
515 520 525
Ala Thr Pro Ala Phe Gly Asn Ser Gln Pro Ser Thr Leu Phe Asn Ser
530 535 540
Thr Pro Ser Thr Gly Gln Thr Gly Ser Ala Phe Gly Gln Thr Gly Ser
545 550 555 560
Ala Phe Gly Gln Phe Gly Gln Ser Ser Ala Pro Ala Phe Gly Gln Asn
565 570 575
Ser Ile Phe Asn Lys Pro Ser Thr Gly Phe Gly Asn Met Phe Ser Ser
580 585 590
Ser Ser Thr Leu Thr Thr Ser Ser Ser Ser Pro Phe Gly Gln Thr Met
595 600 605
Pro Ala Gly Val Thr Pro Phe Gln Ser Ala Gln Pro Gly Gln Ala Ser
610 615 620
Asn Gly Phe Gly Phe Asn Asn Phe Gly Gln Asn Gln Ala Ala Asn Thr
625 630 635 640
Thr Gly Asn Ala Gly Gly Leu Gly Ile Phe Gly Gln Gly Asn Phe Gly
645 650 655
Gln Ser Pro Ala Pro Leu Asn Ser Val Val Leu Gln Pro Val Ala Val
660 665 670
Thr Asn Pro Phe Gly Thr Leu Pro Ala Met Pro Gln Ile Ser Ile Asn
675 680 685
Gln Gly Gly Asn Ser Pro Ser Ile Gln Tyr Gly Ile Ser Ser Met Pro
690 695 700
Val Val Asp Lys Pro Ala Pro Val Arg Ile Ser Ser Leu Leu Thr Ser
705 710 715 720
Arg His Leu Leu His Arg Arg Val Arg Leu Pro Ala Arg Lys Tyr Arg
725 730 735
Pro Gly Glu Asn Gly Pro Lys Val Pro Phe Phe Thr Asp Asp Glu Glu
740 745 750
Ser Ser Ser Thr Pro Lys Ala Asp Ala Leu Phe Ile Pro Arg Glu Asn
755 760 765
Pro Arg Ala Leu Val Ile Arg Pro Val Gln Gln Trp Ser Ser Arg Asp
770 775 780
Lys Ser Ile Leu Pro Lys Glu Gln Arg Pro Thr Ala Pro Leu His Asp
785 790 795 800
Asn Gly Lys Ser Pro Asp Met Ala Thr Asp Ala Ala Asn His Asp Arg
805 810 815
Asn Gly Asn Gly Glu Leu Gly Ala Thr Gly Glu Arg Ile His Thr Ser
820 825 830
Val Asn Ala Asn Gln Lys Pro Asn Gly Thr Thr Arg Ser Asp Gln Ala
835 840 845
Ser Glu Lys Glu Arg Pro Tyr Lys Thr Leu Ser Gly His Arg Ala Gly
850 855 860
Glu Ala Ala Ile Val Tyr Glu His Gly Ala Asp Ile Glu Ala Leu Met
865 870 875 880
Pro Lys Leu Arg Gln Ser Asp Tyr Phe Thr Glu Pro Arg Ile Gln Glu
885 890 895
Leu Ala Ala Lys Glu Arg Ala Asp Pro Gly Tyr Cys Arg Arg Val Arg
900 905 910
Asp Phe Val Val Gly Arg His Gly Tyr Gly Ser Ile Lys Phe Met Gly
915 920 925
Glu Thr Asp Val Arg Arg Leu Asp Leu Glu Ser Leu Val Gln Phe Asn
930 935 940
Thr Arg Glu Val Ile Val Tyr Met Asp Glu Ser Lys Lys Pro Ala Val
945 950 955 960
Gly Gln Gly Leu Asn Lys Pro Ala Glu Val Thr Leu Leu Asn Ile Lys
965 970 975
Cys Ile Asp Lys Lys Thr Gly Lys Gln Phe Thr Glu Gly Glu Arg Val
980 985 990
Glu Lys Tyr Lys Met Met Leu Lys Lys Lys Ala Glu Ala Gln Gly Ala
995 1000 1005
Glu Phe Val Ser Phe Asp Pro Val Lys Gly Glu Trp Lys Phe Arg Val
1010 1015 1020
Glu His Phe Ser Ser Tyr Lys Leu Gly Asp Glu Asp Glu Glu Asp Gly
1025 1030 1035 1040
Val
<210> 14
<211> 997
<212> PRT
<213> Arabidopsis thaliana
<400> 14
Met Phe Gly Ser Ser Asn Asn Asn Pro Phe Gly Gln Ser Ser Ile Ser
1 5 10 15
Ser Pro Phe Gly Thr Gln Thr His Ser Leu Phe Gly Gln Thr Asn Asn
20 25 30
Asn Ala Ser Asn Asn Pro Phe Ala Thr Lys Pro Phe Gly Thr Ser Thr
35 40 45
Pro Phe Gly Ala Gln Thr Gly Ser Ser Met Phe Gly Gly Thr Ser Thr
50 55 60
Gly Val Phe Gly Ala Pro Gln Thr Ser Ser Pro Phe Gly Ala Ser Pro
65 70 75 80
Gln Ala Phe Gly Ser Ser Thr Gln Ala Phe Gly Ala Ser Ser Thr Pro
85 90 95
Ser Phe Gly Ser Ser Asn Ser Pro Phe Gly Gly Thr Ser Thr Phe Gly
100 105 110
Gln Lys Ser Phe Gly Leu Ser Thr Pro Gln Ser Ser Pro Phe Gly Ser
115 120 125
Thr Thr Gln Gln Ser Gln Pro Ala Phe Gly Asn Ser Thr Phe Gly Ser
130 135 140
Ser Thr Pro Phe Gly Ala Ser Thr Thr Pro Ala Phe Gly Ala Ser Ser
145 150 155 160
Thr Pro Ala Phe Gly Val Ser Asn Thr Ser Gly Phe Gly Ala Thr Asn
165 170 175
Thr Pro Gly Phe Gly Ala Thr Asn Thr Thr Gly Phe Gly Gly Ser Ser
180 185 190
Thr Pro Gly Phe Gly Ala Ser Ser Thr Pro Ala Phe Gly Ser Thr Asn
195 200 205
Thr Pro Ala Phe Gly Ala Ser Ser Thr Pro Leu Phe Gly Ser Ser Ser
210 215 220
Ser Pro Ala Phe Gly Ala Ser Pro Ala Pro Ala Phe Gly Ser Ser Gly
225 230 235 240
Asn Ala Phe Gly Asn Asn Thr Phe Ser Ser Gly Gly Ala Phe Gly Ser
245 250 255
Ser Ser Thr Pro Thr Phe Gly Ala Ser Asn Thr Ser Ala Phe Gly Ala
260 265 270
Ser Ser Ser Pro Ser Phe Asn Phe Gly Ser Ser Pro Ala Phe Gly Gln
275 280 285
Ser Thr Ser Ala Phe Gly Ser Ser Ser Phe Gly Ser Thr Gln Ser Ser
290 295 300
Leu Gly Ser Thr Pro Ser Pro Phe Gly Ala Gln Gly Ala Gln Ala Ser
305 310 315 320
Thr Ser Thr Phe Gly Gly Gln Ser Thr Ile Gly Gly Gln Gln Gly Gly
325 330 335
Ser Arg Val Ile Pro Tyr Ala Pro Thr Thr Asp Thr Ala Ser Gly Thr
340 345 350
Glu Ser Lys Ser Glu Arg Leu Gln Ser Ile Ser Ala Met Pro Ala His
355 360 365
Lys Gly Lys Asn Met Glu Glu Leu Arg Trp Glu Asp Tyr Gln Arg Gly
370 375 380
Asp Lys Gly Gly Gln Arg Ser Thr Gly Gln Ser Pro Glu Gly Ala Gly
385 390 395 400
Phe Gly Val Thr Asn Ser Gln Pro Ser Ile Phe Ser Thr Ser Pro Ala
405 410 415
Phe Ser Gln Thr Pro Val Asn Pro Thr Asn Pro Phe Ser Gln Thr Thr
420 425 430
Pro Thr Ser Asn Thr Asn Phe Ser Pro Ser Phe Ser Gln Pro Thr Thr
435 440 445
Pro Ser Phe Gly Gln Pro Thr Thr Pro Ser Phe Arg Ser Thr Val Ser
450 455 460
Asn Thr Thr Ser Val Phe Gly Ser Ser Ser Ser Leu Thr Thr Asn Thr
465 470 475 480
Ser Gln Pro Leu Gly Ser Ser Ile Phe Gly Ser Thr Pro Ala His Gly
485 490 495
Ser Thr Pro Gly Phe Ser Ile Gly Gly Phe Asn Asn Ser Gln Ser Ser
500 505 510
Pro Leu Phe Gly Ser Asn Pro Ser Phe Ala Gln Asn Thr Thr Pro Ala
515 520 525
Phe Ser Gln Thr Ser Pro Leu Phe Gly Gln Asn Thr Thr Pro Ala Leu
530 535 540
Gly Gln Ser Ser Ser Val Phe Gly Gln Asn Thr Asn Pro Ala Leu Val
545 550 555 560
Gln Ser Asn Thr Phe Ser Thr Pro Ser Thr Gly Phe Gly Asn Thr Phe
565 570 575
Ser Ser Ser Ser Ser Leu Thr Thr Ser Ile Ser Pro Phe Gly Gln Ile
580 585 590
Thr Pro Ala Val Thr Pro Phe Gln Ser Ala Gln Pro Thr Gln Pro Leu
595 600 605
Gly Ala Phe Gly Phe Asn Asn Phe Gly Gln Thr Gln Ile Ala Asn Thr
610 615 620
Thr Asp Ile Ala Gly Ala Met Gly Thr Phe Ser Gln Gly Asn Phe Lys
625 630 635 640
Gln Gln Pro Ala Leu Gly Asn Ser Ala Val Met Gln Pro Thr Pro Val
645 650 655
Thr Asn Pro Phe Gly Thr Leu Pro Ala Leu Pro Gln Ile Ser Ile Ala
660 665 670
Gln Gly Gly Asn Ser Pro Ser Ile Gln Tyr Gly Ile Ser Ser Met Pro
675 680 685
Val Val Asp Lys Pro Ala Pro Val Arg Val Ser Pro Leu Leu Thr Ser
690 695 700
Arg His Leu Leu Gln Arg Arg Val Arg Leu Pro Thr Arg Lys Tyr Arg
705 710 715 720
Pro Ser Asp Asp Gly Pro Lys Val Pro Phe Phe Ser Asp Glu Glu Glu
725 730 735
Asn Ser Ser Thr Pro Lys Ala Asp Ala Phe Phe Ile Pro Arg Glu Asn
740 745 750
Pro Arg Ala Leu Phe Ile Arg Pro Val Glu Arg Val Lys Ser Glu His
755 760 765
Pro Lys Asp Ser Pro Thr Pro Leu Gln Glu Asn Gly Lys Arg Ser Asn
770 775 780
Gly Val Thr Asn Gly Ala Asn His Glu Thr Lys Asp Asn Gly Ala Ile
785 790 795 800
Arg Glu Ala Pro Pro Val Lys Val Asn Gln Lys Gln Asn Gly Thr His
805 810 815
Glu Asn His Gly Gly Asp Lys Asn Gly Ser His Ser Ser Pro Ser Gly
820 825 830
Ala Asp Ile Glu Ser Leu Met Pro Lys Leu His His Ser Glu Tyr Phe
835 840 845
Thr Glu Pro Arg Ile Gln Glu Leu Ala Ala Lys Glu Arg Val Glu Gln
850 855 860
Gly Tyr Cys Lys Arg Val Lys Asp Phe Val Val Gly Arg His Gly Tyr
865 870 875 880
Gly Ser Ile Lys Phe Leu Gly Glu Thr Asp Val Cys Arg Leu Asp Leu
885 890 895
Glu Met Val Val Gln Phe Lys Asn Arg Glu Val Asn Val Tyr Met Asp
900 905 910
Glu Ser Lys Lys Pro Pro Val Gly Gln Gly Leu Asn Lys Pro Ala Val
915 920 925
Val Thr Leu Leu Asn Ile Lys Cys Met Asp Lys Lys Thr Gly Thr Gln
930 935 940
Val Met Glu Gly Glu Arg Leu Asp Lys Tyr Lys Glu Met Leu Lys Arg
945 950 955 960
Lys Ala Gly Glu Gln Gly Ala Gln Phe Val Ser Tyr Asp Pro Val Asn
965 970 975
Gly Glu Trp Thr Phe Lys Val Glu His Phe Ser Ser Tyr Lys Leu Gly
980 985 990
Asp Glu Tyr Asp Val
995
<210> 15
<211> 1407
<212> DNA
<213> Arabidopsis thaliana
<400> 15
atgggggaga ttgtggtttt aagtagtgat gatggtatgg agactataaa gaacagagta 60
aagtcatcgg aagttgttca gtgggagaag tatttgccta aaactgtact tagggttttg 120
ttagttgaat ctgattactc aactcgtcaa atcatcactg cccttcttcg taaatgctgt 180
tacaaagttg tagctgtttc tgatggttta gctgcgtggg aggttctaaa ggagaagtca 240
cataacattg atcttatact aacagagctg gatttgccat ctatatctgg ttttgctctg 300
cttgctttgg taatggagca tgaagcttgc aagaacattc ctgtcataat gatgtcttct 360
caagattcga taaaaatggt gttgaagtgt atgctgagag gtgctgctga ttatctaatc 420
aaaccaatga ggaaaaacga gttgaaaaat ctatggcaac atgtttggag aagactgact 480
ttgcgtgatg atcctactgc tcatgctcaa agcttaccag cttcacagca caaccttgaa 540
gatactgatg aaacttgtga agattccaga tatcattcag atcaaggaag tggtgctcag 600
gctatcaatt acaatggtca caataagctg atggagaatg gcaaatcagt ggatgaaaga 660
gacgagttta aggaaacttt tgatgtgaca atggatttga ttggtggaat tgacaagcgt 720
cctgatagta tttataaaga caagagtcga gatgagtgtg ttggtcctga gcttggactt 780
tctctgaaaa gatcttgctc tgtaagtttt gagaaccaag atgaaagcaa gcatcaaaag 840
cttagcctct ctgatgcgtc ggccttctca agatttgagg aaagcaagtc agcagaaaaa 900
gccgtcgttg ctttagagga gagtacttca ggtgagccaa agacaccaac cgaatcacat 960
gaaaagttaa gaaaagtaac atctgatcaa ggaagcgcca caacgagcag caaccaggag 1020
aatatcggat catcaagcgt aagcttccgt aaccaagttc ttcagtccac agtaacgaat 1080
cagaagcaag attcacccat accggtagaa tcaaatcgcg agaaagcagc tagcaaggaa 1140
gtagaagctg gttctcaaag caccaatgag gggattgctg gacaaagcag tagcacagag 1200
aaaccaaagg aagaagaaag tgcgaaacaa cgttggagta gaagccagag agaagctgca 1260
ttgatgaagt tccggttgaa gaggaaagat cgatgctttg acaaaaaggt tcggtaccag 1320
agcaggaaga agctagcaga acaacgtcct cgagtgaaag gccagttcgt gcgaaccgtg 1380
aattcagacg cgtctacaaa atcatga 1407
<210> 16
<211> 2184
<212> DNA
<213> Arabidopsis thaliana
<400> 16
atgaatgcta atgaggaggg ggagggttca cgttacccaa tcactgatcg aaagaccgga 60
gagacgaaat tcgatagggt tgagagtcgg acagagaagc atagtgaaga agagaaaact 120
aatggaatta ctatggatgt gagaaatggg agttcaggtg gactgcaaat tccattgtcg 180
caacaaacag cggcaactgt ctgttgggaa aggtttcttc atgtgagaac cattagagtt 240
ctgcttgtcg aaaatgacga ctgcactcgt tatatcgtta ctgcacttct tcgcaattgt 300
agctatgaag ttgttgaggc gtcaaatggg atacaagctt ggaaggtgtt agaagatcta 360
aacaatcata ttgatattgt gctaacagag gtgatcatgc cttacttatc tggtatcggt 420
ctcttgtgca agattttgaa ccacaaatct cgtcggaaca tccctgtcat catgatgtca 480
tctcatgact caatggggct ggtctttaag tgcttatcga aaggagctgt tgactttctt 540
gttaagccaa taagaaaaaa tgagcttaag atcctttggc agcatgtttg gagaagatgc 600
caaagttcta gtggtagtgg aagtgagagc ggaacgcatc aaactcaaaa gtctgtgaaa 660
tcgaaaagta ttaaaaaatc tgatcaagat tcaggaagca gtgatgagaa tgaaaatggg 720
agcattggcc tgaatgctag tgatggaagt agtgatggga gtggcgctca gagctcttgg 780
acgaaaaaag ctgtggatgt tgatgacagt ccacgagcgg tatctctatg ggaccgagtt 840
gatagcactt gcgcccaagt ggtacattct aaccctgagt ttccaagtaa tcagttggtt 900
gcaccacctg ctgagaagga gactcaagaa catgatgata aatttgaaga tgtcacaatg 960
ggtagagact tggagattag cattcgtaga aactgtgatc tggccctgga gccaaaagat 1020
gaacccctat ctaaaactac tggcattatg agacaggata attcgtttga aaagagctct 1080
agtaaatgga aaatgaaagt tggaaaagga ccattggacc tcagtagcga aagtccttca 1140
agtaaacaaa tgcatgaaga tggaggctcg agtttcaaag ctatgtctag ccaccttcaa 1200
gataacagag aacctgaggc gcctaacact cacttgaaaa ctttagatac aaatgaagct 1260
tctgttaaaa tttctgaaga gctaatgcac gtggaacata gttcaaagag gcatagagga 1320
actaaagatg atgggacact agttagggat gatcggaatg tgctgaggcg ttcagagggc 1380
tcagctttct caaggtataa tccagcctca aatgccaata agatttctgg tgggaactta 1440
ggaagcactt cgcttcagga taataatagt caggatctta taaaaaagac tgaagcagca 1500
tatgattgtc actcgaacat gaatgagagt ctcccccata atcatcgctc acatgtcggt 1560
agcaataact ttgatatgag ttccacgact gagaacaacg ctttcacaaa accaggagct 1620
ccaaaagtaa gctcagcagg atcttcatca gtgaagcatt catcgtttca gcctttaccc 1680
tgtgatcatc ataataatca tgcctcctat aaccttgtcc atgtcgctga gaggaagaag 1740
ctaccgccac aatgtggatc ctcaaatgtg tacaacgaaa cgattgaagg taacaacaac 1800
acagtgaatt acagtgtgaa tggaagtgta tcaggtagtg gtcatggaag taatgggcca 1860
tatggaagca gtaacggtat gaatgctgga ggaatgaata tgggaagtga taatggtgct 1920
ggcaaaaatg gaaatggcga tggtagtgga agcggaagtg gaagtggtag cggaaacttg 1980
gcggatgaaa ataagatctc tcaaagggaa gctgctttga caaagttccg tcagaagaga 2040
aaagagaggt gcttccgaaa gaaggtacga taccaaagcc ggaaaaaact agcagaacaa 2100
cgccctcgag tgcgaggcca atttgtgcgt aaaacagccg ctgcaactga tgataacgac 2160
ataaaaaaca ttgaggatag ctaa 2184
<210> 17
<211> 1677
<212> DNA
<213> Arabidopsis thaliana
<400> 17
atgactagta gcgaggaagt agttgaagtg acggtggtta aagcacctga agctggcgga 60
ggaaagttat cacgtcggaa gattcggaag aaagacgccg gtgttgatgg tttggtgaag 120
tgggagagat ttctcccgaa aatcgcgctt agagttttgc tcgttgaagc tgatgattct 180
actagacaga ttatcgctgc tcttctcagg aaatgtagtt acagagttgc tgcagtacct 240
gatggcttaa aagcttggga gatgctaaaa ggaaagcctg aaagtgttga tttgatatta 300
acagaggttg atctaccttc aatatctgga tatgctctgc taacacttat catggagcat 360
gatatttgca agaacattcc tgttataatg atgtcgacac aggactcggt gaatactgtg 420
tataagtgta tgttgaaagg tgcggctgat tatcttgtta agccgttgag gaggaatgag 480
cttagaaatc tttggcagca tgtctggaga agacaaactt cacttgctcc tgatagcttt 540
ccatggaatg agagtgttgg acagcagaaa gccgagggtg cgtctgcaaa caactcgaac 600
ggaaagagag acgatcatgt tgtgagtggg aatggtggtg atgcccagag ctcgtgtaca 660
agaccagaga tggaaggtga gagcgcagac gtggaggtta gtgcgagaga cgcagtacag 720
atggagtgcg caaagtctca gtttaatgag acacggcttc tagcaaatga gttgcagagt 780
aagcaagcag aagccattga cttcatggga gcatcgttta gaagaactgg acgacgtaac 840
agagaagaaa gtgttgctca atacgaatct cggatagagc ttgatctttc tctgagaaga 900
cctaatgctt ctgagaacca atcttctgga gaccggcctt ctcttcatcc ttctagtgcc 960
tcagctttca cacggtacgt tcacaggccg ttgcagacac aatgttcagc ctccccagtg 1020
gttactgatc aaagaaagaa tgttgcagca agtcaagatg ataacattgt gctaatgaac 1080
caatacaata catctgaacc gcctccaaat gctccaagaa gaaacgacac cagcttttac 1140
actggagctg actcacctgg tccaccgttt agtaatcagc tgaattcttg gccgggacag 1200
agttcatacc ctacgccaac ccctatcaac aatatacagt tcagagatcc caacacagct 1260
tatacatctg caatggctcc tgcttcactc tccccaagcc ctagttccgt tagcccgcat 1320
gagtacagtt ccatgtttca cccattcaac agtaaacccg aggggttaca agaccgggat 1380
tgttccatgg atgtagatga gaggagatac gtctcttctg caaccgaaca tagtgcaata 1440
ggcaatcaca ttgatcagct tattgagaag aagaacgaag atggctattc attatccgtc 1500
gggaaaattc agcaatctct tcaacgagaa gccgctttaa ccaaattccg aatgaagcga 1560
aaggacagat gttatgagaa aaaggttcgt tacgagagcc ggaagaaatt agcagagcaa 1620
cgaccacgaa tcaaaggcca attcgttcgt caagtccaat ccacacaagc tccatag 1677
<210> 18
<211> 1827
<212> DNA
<213> Arabidopsis thaliana
<400> 18
atggagacaa attcgtctgg agaagatctg gttattaaga ctcggaagcc atatacgata 60
acaaagcaac gtgaaaggtg gactgaggaa gaacataata gattcattga agctttgagg 120
ctttatggta gagcatggca gaagattgaa gaacatgtag caacaaaaac tgctgtccag 180
ataagaagtc acgctcagaa atttttctcc aaggtagaga aagaggctga agctaaaggt 240
gtagctatgg gtcaagcgct agacatagct attcctcctc cacggcctaa gcgtaaacca 300
aacaatcctt atcctcgaaa gacgggaagt ggaacgatcc ttatgtcaaa aacgggtgtg 360
aatgatggaa aagagtccct tggatcagaa aaagtgtcgc atcctgagat ggccaatgaa 420
gatcgacaac aatcaaagcc tgaagagaaa actctgcagg aagacaactg ttcagattgt 480
ttcactcatc agtatctctc tgctgcatcc tccatgaata aaagttgtat agagacatca 540
aacgcaagca ctttccgcga gttcttgcct tcacgggaag agggaagtca gaataacagg 600
gtaagaaagg agtcaaactc agatttgaat gcaaaatctc tggaaaacgg taatgagcaa 660
ggacctcaga cttatccgat gcatatccct gtgctagtgc cattggggag ctcaataaca 720
agttctctat cacatcctcc ttcagagcca gatagtcatc cccacacagt tgcaggagat 780
tatcagtcgt ttcctaatca tataatgtca acccttttac aaacaccggc tctttatact 840
gccgcaactt tcgcctcatc attttggcct cccgattcta gtggtggctc acctgttcca 900
gggaactcac ctccgaatct ggctgccatg gccgcagcca ctgttgcagc tgctagtgct 960
tggtgggctg ccaatggatt attaccttta tgtgctcctc ttagttcagg tggtttcact 1020
agtcatcctc catctacttt tggaccatca tgtgatgtag agtacacaaa agcaagcact 1080
ttacaacatg gttctgtgca gagccgagag caagaacact ccgaggcatc aaaggctcga 1140
tcttcactgg actcagagga tgttgaaaat aagagtaaac cagtttgtca tgagcagcct 1200
tctgcaacac ctgagagtga tgcaaagggt tcagatggag caggagacag aaaacaagtt 1260
gaccggtcct cgtgtggctc aaacactccg tcgagtagtg atgatgttga ggcggatgca 1320
tcagaaaggc aagaggatgg caccaatggt gaggtgaaag aaacgaatga agacactaat 1380
aaacctcaaa cttcagagtc caatgcacgc cgcagtagaa tcagctccaa tataaccgat 1440
ccatggaagt ctgtgtctga cgagggtcga attgccttcc aagctctctt ctccagagag 1500
gtattgccgc aaagttttac atatcgagaa gaacacagag aggaagaaca acaacaacaa 1560
gaacaaagat atccaatggc acttgatctt aacttcacag ctcagttaac accagttgat 1620
gatcaagagg agaagagaaa cacaggattt cttggaatcg gattagatgc ttcaaagcta 1680
atgagtagag gaagaacagg ttttaaacca tacaaaagat gttccatgga agccaaagaa 1740
agtagaatcc tcaacaacaa tcctatcatt catgtggaac agaaagatcc caaacggatg 1800
cggttggaaa ctcaagcttc cacatga 1827
<210> 19
<211> 1938
<212> DNA
<213> Arabidopsis thaliana
<400> 19
atggatacta atacatctgg agaagaatta ttagctaagg caagaaagcc atatacaata 60
acaaagcagc gagagcgatg gactgaggat gagcatgaga ggtttctaga agccttgagg 120
ctttatggaa gagcttggca acgaattgaa gaacatattg ggacaaagac tgctgttcag 180
atcagaagtc atgcacaaaa gttcttcaca aagttggaga aagaggctga agttaaaggc 240
atccctgttt gccaagcttt ggacatagaa attccgcctc ctcgtcctaa acgaaaaccc 300
aatactcctt atcctcgaaa gcctgggaac aacggtacat cttcctctca agtatcatca 360
gcaaaagatg caaaacttgt ttcatcggcc tcttcttcac agttgaatca ggcgttcttg 420
gatttggaaa aaatgccgtt ctctgagaaa acatcaactg gaaaagaaaa tcaagatgag 480
aattgctcgg gtgtttctac tgtgaacaag tatcccttac caacgaaaca ggtaagtggc 540
gacattgaaa caagtaagac ctcaactgtg gacaacgcgg ttcaagatgt tcccaagaag 600
aacaaagaca aagatggtaa cgatggtact actgtgcaca gcatgcaaaa ctacccttgg 660
catttccacg cagatattgt gaacgggaat atagcaaaat gccctcaaaa tcatccctca 720
ggtatggtat ctcaagactt catgtttcat cctatgagag aagaaactca cgggcacgca 780
aatcttcaag ctacaacagc atctgctact actacagctt ctcatcaagc gtttccagct 840
tgtcattcac aggatgatta ccgttcgttt ctccagatat catctacttt ctccaatctt 900
attatgtcaa ctctcctaca gaatcctgca gctcatgctg cagctacatt cgctgcttcg 960
gtctggcctt atgcgagtgt cgggaattct ggtgattcat caaccccaat gagctcttct 1020
cctccaagta taactgccat tgccgctgct acagtagctg ctgcaactgc ttggtgggct 1080
tctcatggac ttcttcctgt atgcgctcca gctccaataa catgtgttcc attctcaact 1140
gttgcagttc caactccagc aatgactgaa atggataccg ttgaaaatac tcaaccgttt 1200
gagaaacaaa acacagctct gcaagatcaa aacttggctt cgaaatctcc agcttcatca 1260
tctgatgatt cagatgagac tggagtaacc aagctaaatg ccgactcaaa aaccaatgat 1320
gataaaattg aggaggttgt tgttactgcc gctgtgcatg actcaaacac tgcccagaag 1380
aaaaatcttg tggaccgctc atcctgtggc tcaaatacac cttcagggag tgacgcagaa 1440
actgatgcat tagataaaat ggagaaagat aaagaggatg tgaaggagac agatgagaat 1500
cagccagatg ttattgagtt aaataaccgt aagattaaaa tgagagacaa caacagcaac 1560
aacaatgcaa ctactgattc gtggaaggaa gtctccgaag agggtcgtat agcgtttcag 1620
gctctctttg caagagaaag attgcctcaa agcttttcgc ctcctcaagt ggcagagaat 1680
gtgaatagaa aacaaagtga cacgtcaatg ccattggctc ctaatttcaa aagccaggat 1740
tcttgtgctg cagaccaaga aggagtagta atgatcggtg ttggaacatg caagagtctt 1800
aaaacgagac agacaggatt taagccatac aagagatgtt caatggaagt gaaagagagc 1860
caagttggga acataaacaa tcaaagtgat gaaaaagtct gcaaaaggct tcgattggaa 1920
ggagaagctt ctacatga 1938
<210> 20
<211> 993
<212> DNA
<213> Arabidopsis thaliana
<400> 20
atggagtttt catcacaaga cgacgatttt ggaggagacg attccgctgc taatgccacc 60
agggcttcag gtaatagaag aagcttcggt gatcttgaag acgatgaaga tgatattttc 120
ggatcaacaa cggtagcgcc tggtgttaga actgggatga ttttgtctct ccgaggaagt 180
cttaagaatt gtaaagatga tcttgcttca tgtcaaaatg agctcgagtc agcaaaaaca 240
gagattcaga agtggaagtc agcgtttcag aatgagtcct ttgttcccgc tggaaaatct 300
cctgaaccaa gatttttgat tgattatatt caaaacctaa aatcttctga gaaatctttg 360
aaagaacagt tagaaatcgc aaagagaaaa gaagcgtcat gcattgtaca atatgcgaaa 420
cgggaacaag aaatggcaga attgaagtca gctgttcgcg atttgaaatc tcaactcaag 480
ccagcgtcaa tgcaggcgag gaggttgtta ctggatccag caattcatga agaattttca 540
cgtctgaaga atctagtaga ggaaaaagac aagaagatca aggaactcca ggacaacatt 600
gcagcagtta cttttactcc tcaaagcaag aatggaaaga tgcttatggc aaagtgcaga 660
accctgcaag aggaaaatga ggagattggg caccaagctg ccgaaggaaa gattcatgaa 720
ctagcaataa agcttgcaat gcagaagtct caaaacgcgg aacttagaag tcaatttgaa 780
ggactgtaca aacacatgga ggaattaact aatgatgttg agagatcaaa tgaaacggtg 840
ataatattgc aagagaaact ggaagagaaa gagaaggaga tagagagagt aaagaaagga 900
ctggaaattg tgtctgagct agtaggtgac aagaaagatg aagttgatga aattgatgaa 960
gatgcaaaag aagaaattgc tggtggagaa tag 993
<210> 21
<211> 576
<212> DNA
<213> Arabidopsis thaliana
<400> 21
atggcgaata agttcactag acaacagatt tcagagttta gggaacagtt cagcgtatac 60
gacaagaatg gtgatggtca cattaccaca gaggagttcg gtgccgtgat gcgttccctc 120
ggtttaaacc tgacccaagc tgagcttcag gaggagatca acgattcgga tttagatggt 180
gacggaacca tcaatttcac tgagttcttg tgcgcaatgg ctaaggacac ttactctgag 240
aaagacctca agaaagattt cagactcttt gacatagaca agaatggttt catctcagct 300
gctgaaatga gatatgtgag gactatcctc cggtggaagc aaactgatga agaaatcgat 360
gagattatca aggcagctga tgttgatggt gatggtcaga tcaactacag agagtttgcc 420
aggcttatga tggccaagaa tcaaggtcat gatactaaat atgacacaac tggtggcact 480
ttggagaggg acttggcggc cggggttgcc aaaaatatca tcgcagcgcc aatgaccgac 540
ttcatcaaaa atttgttcga agcgttgttt tcttga 576
<210> 22
<211> 2016
<212> DNA
<213> Arabidopsis thaliana
<400> 22
atgcccctta ttcatcggaa aaagccgacg gagaaaccat cgacgccgcc atctgaagag 60
gtggtgcacg atgaggattc gcaaaagaaa ccacacgaat cttccaaatc ccaccataag 120
aaatcgaacg gaggagggaa gtggtcgtgc atcgattctt gttgttggtt cattgggtgt 180
gtgtgtgtaa cctggtggtt tcttctcttc ctttacaacg caatgcctgc gagcttccct 240
cagtatgtaa cggagcgaat cacgggtcct ttgcctgacc cgcccggtgt taagctcaaa 300
aaagaaggtc ttaaggcgaa acatcctgtt gtcttcattc ctgggattgt caccggtggg 360
ctcgagcttt gggaaggcaa acaatgcgct gatggtttat ttagaaaacg tttgtggggt 420
ggaacttttg gtgaagtcta caaaaggcct ctatgttggg tggaacacat gtcacttgac 480
aatgaaactg ggttggatcc agctggtatt agagttcgag ctgtatcagg actcgtggct 540
gctgactact ttgctcctgg ctactttgtc tgggcagtgc tgattgctaa ccttgcacat 600
attggatatg aagagaaaaa tatgtacatg gctgcatatg actggcggct ttcgtttcag 660
aacacagagg tacgtgatca gactcttagc cgtatgaaaa gtaatataga gttgatggtt 720
tctaccaacg gtggaaaaaa agcagttata gttccgcatt ccatgggggt cttgtatttt 780
ctacatttta tgaagtgggt tgaggcacca gctcctctgg gtggcggggg tgggccagat 840
tggtgtgcaa agtatattaa ggcggtgatg aacattggtg gaccatttct tggtgttcca 900
aaagctgttg cagggctttt ctctgctgaa gcaaaggatg ttgcagttgc cagagcgatt 960
gccccaggat tcttagacac cgatatattt agacttcaga ccttgcagca tgtaatgaga 1020
atgacacgca catgggactc aacaatgtct atgttaccga agggaggtga cacgatatgg 1080
ggcgggcttg attggtcacc ggagaaaggc cacacctgtt gtgggaaaaa gcaaaagaac 1140
aacgaaactt gtggtgaagc aggtgaaaac ggagtttcca agaaaagtcc tgttaactat 1200
ggaaggatga tatcttttgg gaaagaagta gcagaggctg cgccatctga gattaataat 1260
attgattttc gaggtgctgt caaaggtcag agtatcccaa atcacacctg tcgtgacgtg 1320
tggacagagt accatgacat gggaattgct gggatcaaag ctatcgctga gtataaggtc 1380
tacactgctg gtgaagctat agatctacta cattatgttg ctcctaagat gatggcgcgt 1440
ggtgccgctc atttctctta tggaattgct gatgatttgg atgacaccaa gtatcaagat 1500
cccaaatact ggtcaaatcc gttagagaca aaattaccga atgctcctga gatggaaatc 1560
tactcattat acggagtggg gataccaacg gaacgagcat acgtatacaa gcttaaccag 1620
tctcccgaca gttgcatccc ctttcagata ttcacttctg ctcacgagga ggacgaagat 1680
agctgtctga aagcaggagt ttacaatgtg gatggggatg aaacagtacc cgtcctaagt 1740
gccgggtaca tgtgtgcaaa agcgtggcgt ggcaagacaa gattcaaccc ttccggaatc 1800
aagacttata taagagaata caatcactct ccgccggcta acctgttgga agggcgcggg 1860
acgcagagtg gtgcccatgt tgatatcatg ggaaactttg ctttgatcga agatatcatg 1920
agggttgccg ccggaggtaa cgggtctgat ataggacatg accaggtcca ctctggcata 1980
tttgaatggt cggagcgtat tgacctgaag ctgtga 2016
<210> 23
<211> 2883
<212> DNA
<213> Arabidopsis thaliana
<400> 23
atgtctactt ctcatcatca tcatcaccct ccttatctca tcaccacatt attcttcttg 60
tttcttaact tctcctgcct ccatgcaaat gaactcgagc ttctcttatc attcaaatcc 120
tcaattcaag accctctaaa acacctctcc tcttggtctt actcttcaac caatgatgtg 180
tgtctttgga gtggcgtcgt ttgcaacaac atctctcgtg ttgtctctct cgatctctcc 240
ggcaagaaca tgtccggtca aatcctcacc gccgctactt ttcgcctacc ttttcttcaa 300
actatcaacc tctcaaacaa caacttgtcc ggtccaatac ctcacgatat ctttaccact 360
tcgtctcctt ctctccgtta cctcaactta agcaacaaca acttttccgg ctccatccct 420
cgaggctttc ttccgaacct ctacacgtta gatctttcca acaacatgtt caccggtgaa 480
atctacaacg acatcggggt tttctctaac cttagagtcc ttgatctcgg tggaaatgtc 540
ttaaccggcc atgtaccggg ctatcttgga aacctctcaa gattagagtt cttaacattg 600
gcttcaaacc agttaaccgg aggtgtaccg gtggaattag ggaagatgaa aaacttgaaa 660
tggatatact tgggatacaa caatctctca ggagaaatcc cttaccaaat cggtgggtta 720
tcctctctta accaccttga tctcgtctac aacaatctct ctggaccgat acctccttca 780
ctaggtgact tgaagaagct tgagtatatg tttctctatc aaaacaagct ctccggtcag 840
atcccaccgt ccatcttctc cctccaaaac ctaatttctc tcgactttag cgataactcg 900
ctctcgggag agatccctga gctcgtggct cagatgcaaa gcttggagat tctccatctc 960
ttctctaata acttaacagg aaaaattcca gaaggagtaa cttctttgcc acgtctaaaa 1020
gttcttcagc tttggtcaaa cagattttcc ggtggaattc cggcaaatct tgggaaacat 1080
aacaatctca ctgttcttga tctttctacc aacaatctca ccggaaaact ccctgacact 1140
ctttgtgatt ctggccatct cactaagctc atcctcttct ctaactctct agacagccaa 1200
atcccaccga gtttgggcat gtgtcagagc ttagaacgcg tgaggcttca aaacaatggc 1260
ttttcaggca agttacctcg aggtttcacc aagttgcaac tcgttaactt tttggactta 1320
tccaacaaca acctccaagg taacatcaac acatgggaca tgccacaact tgagatgtta 1380
gacctcagtg tgaacaaatt cttcggtgaa ttaccggatt tttctagaag caaaagactc 1440
aagaagctcg atttatcacg gaacaaaatc tctggagtgg ttccacaagg gctcatgacg 1500
tttccggaaa taatggattt ggatttaagt gagaacgaaa tcactggagt gatcccaagg 1560
gagttgtctt cttgcaaaaa tctagtgaat cttgacttga gccacaacaa ttttaccgga 1620
gagatccctt cgagtttcgc agaattccaa gttctcagcg atcttgattt gtcatgcaac 1680
caattatcag gcgagattcc gaagaatcta ggaaacattg agtctcttgt tcaagtcaac 1740
atctctcata atcttcttca cggaagctta cctttcaccg gagcttttct tgccataaac 1800
gcaacagcag ttgagggtaa catcgatctt tgtagcgaaa attccgctag cggtttacgt 1860
ccttgcaagg ttgtaagaaa gagaagtacg aagagttggt ggttaatcat cacttcaacc 1920
tttgcagctt tcttggctgt cctagtctct ggtttcttta tcgttctcgt ctttcaaaga 1980
acgcataacg ttttggaggt caagaaagtg gaacaagaag atggtacaaa gtgggaaact 2040
caattcttcg attcaaaatt catgaaatcg tttacggtga acacaattct atcgtctctt 2100
aaggaccaaa acgttcttgt ggataaaaac ggcgtgcatt tcgttgttaa ggaggtcaag 2160
aagtatgatt ctcttcccga gatgatatcc gatatgagga aactttctga ccacaaaaac 2220
attcttaaga tagttgctac gtgccggtcg gagactgtgg cgtacttgat acatgaggac 2280
gtcgaaggga aacggctgag ccaggtttta agtggtttga gttgggagag acggaggaag 2340
attatgaagg gaatcgtcga agctcttcgg tttttacatt gccggtgttc tccagctgtt 2400
gttgccggta atttatcgcc ggagaatatt gtcatcgacg tcaccgatga accaaggctt 2460
tgtctcggtc ttccgggctt actttgcatg gatgctgctt acatggcccc agaaacgaga 2520
gagcacaagg agatgacaag taaaagtgac atctatggtt ttggaatcct cctccttcat 2580
ctcctcaccg gtaaatgttc ctccagtaat gaggacatcg aatctggagt taacggaagt 2640
ttggtcaagt gggctagata ttcgtattcg aattgccata tcgacacgtg gatcgactca 2700
tccattgaca catcagtgca tcagcgcgag attgtccatg ttatgaactt ggctttgaaa 2760
tgtacggcca ttgatccgca agagaggcca tgcaccaata acgtgttaca agcattagag 2820
tctacctcat cgtcaagttc ttcttgcact acttatttgt caaagatact atcgttggcc 2880
tga 2883
<210> 24
<211> 3273
<212> DNA
<213> Arabidopsis thaliana
<400> 24
atgccacgta accctagatt ctgcttcttc ctcttccttc tttttcactc ctctcttttc 60
ttctccatcc cctgtttttc catagacgaa cagggtctag ctctcctctc atggaaatct 120
cagttgaaca tctccggaga cgctttatct tcttggaaag cctccgaatc gaatccttgt 180
caatgggtgg gaatcaaatg caacgaaaga ggtcaagtct cggagataca actccaagtc 240
atggattttc aaggtccgtt accggcgacg aatctccgac agataaagtc tctgactttg 300
ctcagcttaa cctccgtgaa tctcactggt tcaatcccta aggagcttgg agacttgtcg 360
gagctagaag ttcttgattt agctgataat tctctctctg gtgaaatccc tgtggatatc 420
ttcaagctca agaaactaaa gattctgtct ctcaacacaa ataatctcga aggtgtgatt 480
ccatcggagt tagggaatct cgttaacctc atcgagctca ctctcttcga caataaactc 540
gccggagaga ttcctagaac catcggagaa ctcaagaatc tagaaatctt ccgtgcaggt 600
ggtaacaaga atctcagagg agagcttcct tgggagattg gtaactgcga gagtcttgtg 660
actttaggtc tcgccgaaac aagtctctcc ggtagacttc cggcgtcgat cggaaacctg 720
aaaaaggttc agacaatagc tctttacacg tcactcttgt ctggtccaat ccctgatgag 780
attggaaact gcacagagct tcaaaacctc tacttgtacc aaaactcaat ctctggatcg 840
attcctgtat caatgggacg tctcaagaag cttcaaagtc ttctcttatg gcaaaacaat 900
ctcgtcggaa agatccctac cgagctaggc acctgtccgg agcttttcct cgtcgattta 960
tcggaaaatc tcctcaccgg aaacatccca agaagcttcg gaaaccttcc aaatctccaa 1020
gagcttcagc taagtgttaa ccagctctcc ggtacaatcc ctgaagaact cgcgaattgc 1080
acgaagttga cgcatttaga gatcgataac aaccaaatct ccggcgagat tccgccgttg 1140
atcgggaaat taacaagctt gacgatgttc tttgcgtggc agaatcagtt aaccggaata 1200
attccagagt ctctttctca atgtcaagag cttcaagcga ttgatctctc ctacaacaat 1260
ctctctggtt cgatacctaa tggaatcttt gagattcgaa acctcacgaa gcttcttctt 1320
ctctctaact acttatctgg attcatacca ccggatattg gaaactgcac gaatctttac 1380
cggttaagac tcaacggtaa cagactcgcg gggaatattc cggcggagat tgggaatctg 1440
aaaaatctca acttcatcga tataagtgag aatcgtctca tcggaaacat tcctccggag 1500
atctccggtt gtacaagtct cgaattcgtc gatctacatt caaacggttt aaccggtggt 1560
ttacccggta cacttccgaa gagcttacaa ttcattgatt tatccgataa ttcattaacc 1620
ggttctctac caaccggaat cggatcgtta accgaactca cgaagctcaa tctcgcgaag 1680
aatcgtttct ccggcgaaat ccctcgagag atatcttcct gtcggagtct tcagcttctc 1740
aacctcggcg acaatggctt caccggagaa atccctaacg agttaggacg gatcccgtct 1800
cttgcgatct ctctaaatct cagctgcaat cacttcaccg gagagatccc gtcgagattc 1860
tctagcctca ctaatctcgg aaccctcgat gtctctcaca acaaactcgc cggaaaccta 1920
aacgtcttag ctgatctaca gaacctcgtc tcactcaaca tctccttcaa cgaattctca 1980
ggcgagttac caaatactct gtttttcagg aaacttccac tctctgttct tgaatcaaac 2040
aaagggctat ttatttcgac ccgacccgag aatgggatcc aaacccgaca ccgttcggct 2100
gtcaaagtaa ccatgtcgat cctcgtagca gcaagcgtcg ttcttgttct catggcggtt 2160
tacactctcg tcaaagctca acgaatcacc ggaaaacaag aggagttaga ttcttgggaa 2220
gtgactcttt atcagaaact cgatttctcc atcgacgaca tcgtcaagaa cttaacttca 2280
gctaacgtga tcggaactgg aagctccggt gtagtttaca gagtcacaat cccgtccggt 2340
gaaactttag ctgtgaagaa aatgtggtca aaggaagaaa acagagcgtt taactcagag 2400
atcaacactc ttggatcgat tcgacatagg aacataatcc gtcttttggg ttggtgttcg 2460
aatcggaatc tgaagctttt gttctatgat tatcttccta acggaagttt aagctctctg 2520
cttcacggtg ccggtaaagg aagtggagga gctgattggg aagcacgtta cgacgtcgtt 2580
ttaggcgttg cacatgcact agcttatctt catcatgatt gtcttcctcc gattctacac 2640
ggtgacgtta aagctatgaa tgtcttattg ggttcccgct tcgaatctta cttagccgat 2700
ttcggtttag caaaaatcgt ctccggtgag ggagttaccg atggagattc gtctaaattg 2760
agtaaccggc ctccgttagc cggttcttat ggttacatgg ctccagaaca tgcttcgatg 2820
caacatataa cagaaaagag tgatgtgtat agctatggag tggtgctact agaagtttta 2880
accgggaagc atccattgga cccggatcta cccggaggtg ctcatttggt tcaatgggtg 2940
agagatcatt tagccggaaa gaaagatcct agagaaattc ttgacccgag actccgcggg 3000
cgggcagatc ctataatgca tgagatgcta caaactctag cggtctcgtt cctttgtgtg 3060
agcaacaagg catccgatcg gcctatgatg aaagacattg tggcaatgct taaagagatt 3120
aggcagtttg atatggatag atcggaatcc gatatgataa aaggcggaaa atgcgaaaaa 3180
tggcagccgc aaccgttacc accggagaaa attgtcagta ctcctcgagg ttcatctaat 3240
tgttcgtttg cttactcgga tgaatccgta taa 3273
<210> 25
<211> 2046
<212> DNA
<213> Arabidopsis thaliana
<400> 25
atgtctggtt ctgtatctgg ttgtggttct ggtggttgta gtattgtatg gtttagaaga 60
gatcttaggg ttgaagataa tccagcttta gcagcagcag taagagctgg tccagtgatt 120
gctctgtttg tttgggcacc agaagaagaa ggacactatc atccaggtag ggtttctagg 180
tggtggctca agaacagttt ggctcagctt gattcttctc ttagaagtct tggtacttgt 240
cttatcacca agagatctac tgatagtgtt gcttctcttc ttgatgttgt taaatccact 300
ggtgcttctc agatcttctt caaccatttg tatgatccat tgtctttggt gcgtgatcac 360
cgagctaaag atgttttgac ggcgcaaggc atagcggttc gatcattcaa cgcagacttg 420
ctttatgagc catgggaagt gactgatgaa ttaggccgtc ctttctctat gtttgctgcg 480
ttttgggaga gatgtcttag tatgccttat gaccctgagt ctcctcttct tccacctaag 540
aagatcattt caggggatgt gtctaaatgt gttgcggatc cattggtgtt tgaggatgac 600
tctgagaaag gaagcaatgc acttctggct cgtgcttggt ctcctggatg gagtaatggt 660
gataaagctc tcacaacgtt tataaacggt ccattgcttg aatactctaa gaaccgcaga 720
aaagccgata gtgctacaac ctcgtttctt tctccacact tgcattttgg ggaagtgagt 780
gtgagaaaag tttttcatct tgttcggatc aaacaggtcg cgtgggcaaa cgaaggaaac 840
gaggccgggg aagaaagcgt gaatcttttc ctgaaatcta ttggtctcag ggagtattct 900
aggtacataa gttttaacca tccatattcc catgaaagac cacttcttgg ccatctaaag 960
ttcttccctt gggctgtgga tgagaactat ttcaaggcat ggaggcaagg ccggactgga 1020
tatccgttgg tcgatgccgg gatgagagag ttatgggcta ctggttggtt gcatgatcgc 1080
ataagagtag ttgtttcaag cttctttgtt aaagtgcttc aattaccatg gagatggggg 1140
atgaagtatt tctgggacac acttcttgat gcggatttag aaagcgatgc tcttggttgg 1200
caatacatta ccggtactct cccggatagc cgggagtttg atcgcataga taaccctcag 1260
tttgaagggt acaagtttga tccaaatggt gaatacgtaa ggcgatggct tcctgaactc 1320
tctagactcc cgacagactg gatacatcat ccgtggaacg cacctgagtc cgttcttcaa 1380
gctgctggta tcgagcttgg atcaaactat cctctaccaa ttgtaggatt agacgaagca 1440
aaagcacggc ttcatgaagc gctttcacag atgtggcaac tagaagctgc ttcaagagct 1500
gcaatagaga acggatccga agaaggactt ggagattctg ctgaggtaga ggaagctcct 1560
atagagttcc caagggacat tacaatggaa gagactgaac caaccagact caacccaaac 1620
aggagatatg aggatcagat ggttccaagc attacttctt ctttgatcag acctgaagaa 1680
gacgaagagt cgtctcttaa tttgagaaat tcagtaggag atagcagagc agaggttcca 1740
aggaacatgg ttaacaccaa ccaagctcag cagcggagag cagaaccggc ttcaaaccaa 1800
gtcactgcta tgattccaga atttaatatc agaattgttg cagagagcac tgaagactca 1860
acagcggaat cttccagcag cggaaggaga gaaagaagcg gaggcatagt ccccgagtgg 1920
tctccagggt actcagagca gttccctagt gaagaaaatg gtattggagg aggaagtaca 1980
acgtctagct acttgcagaa tcaccatgaa atactgaact ggagacggct ttcacaaacc 2040
gggtaa 2046
<210> 26
<211> 4503
<212> DNA
<213> Arabidopsis thaliana
<400> 26
atggaggaga atcgtcggaa tccgtcggcc ggtatggaag ttccagttgc cggcggcgga 60
aatgtcgtca aatggattga gatatctgtt ccttcacctt ctgtttcatc ttctagtatc 120
ggtgctaatt caagtgagga caatgagtgt gttcagcttc ctttgtctga agactacgct 180
tctagctctg taattgggga accttcgatc tctttcgttt ggagaatcaa caagacgagt 240
ccaaatgctc tcgagcttct tcagctctca gctaagtctg gatttccaat aacaggactg 300
cgtttcgtct ttgctcagac tctttctcct tttgcttttg tatacgccga tgagggtggt 360
gatagtggtc gtcttgtcta ctttctttac tctctcacgc cgtctggtgt tgtctacgtt 420
cttaaactct cgaatacgtt agcatataag tctggttcag tcttcccgct tgatcatttg 480
attcacttgg atgttcgacc ttacttgaac gagagtcgtg ttactagtgt tgctgcatcg 540
cctggtttca tttttctcgg gaggtccgat ggttgtgtct cttgcttcca acctattgtg 600
tattttcaga aatcttcagg tttccaccag gagctgcgtg atgatacagg atttggtcgt 660
ctgtggggat tcgtaagggg gacagttgtt gcagccgtgc aagatttatt tatatcagaa 720
gttcatggaa gaaattatct atgtgtgctt catgctgacg gggcattacg tgtctgggat 780
attttgactt atagcagggt tttatgtcag agtatagctg ctaagaacct tgagggggtt 840
atgtgtgtga ggttatggtt gggcaaagct gattacgatt ctggcatcat tccattagct 900
gtcttgtata gaaagagtat gaatgacagc atggacgtga tcactgtata tggcctgcac 960
tttagttctg cggaggggat agctttgtct ctagattctg gattacagaa tataccactg 1020
gaagaggggg aattgcggga tgtcagattt acatccgaca agatctggac tctaaaggcc 1080
aatgaattaa catcttacat gttgtgccag aaatctagca ccatggaagc gcagtcttac 1140
acgttgcagg aagactacat ttctgaacag ctatttctga gttctaggag ctcttcacat 1200
gatcttcttt tgactactca ttcactgttt tcatccgcaa aggatcaaat tatgggattc 1260
atttcgtcaa tcttcttacg caggcttctt tgtcctggaa tttttcacaa tgttgcctta 1320
cgtctaactt tactggacca caacaaaaac tggactgatt ccgagtttca atctttaagt 1380
cttgatgagc ttacaagcga gattctttta ctggttgagc atgaggttac agctgaaact 1440
tctatttcag tttttcattg gtggaaaaac ttttgtacat cctatctcca tcattggtgc 1500
agtaataatg aacctcgcac gttgttggtt cagtcagatg ttattggttt agttagaaat 1560
aattctgtat cactgttttt tagattggag aacgctgagc acagccttgg aggttcttcc 1620
tccgaacaca gcaacctgac gagcttagac ttgggcgtgt ctcacagcga ccatgaaatt 1680
ctggcagagg tactaagatg tacttcgaag atcagtaaac agtggggtgg tgctccttat 1740
gccatgtatt atgaatcaat taccggaagg ccaattatct catcggatga aatcgttcct 1800
cgcttagtta acatccttga gtcgggatat tctacgacca taggtcaacg tacttggtca 1860
gatcttggtg ctgatagagc atgggaaaaa gagctagaag ctcataaaaa tcttagaaca 1920
ttctccattg acatgctgct gtctctctct gctctatgtc aaagggctgg atcttgggaa 1980
aaagtcttta ctatcatgga gcactatttg cagtatttgg tccctaaaaa atctatgcag 2040
aaaaatgatg gtgaggcatt atctgatatc tgtagttcta tcctcgtcca agccacttct 2100
cagtttgtaa aggtgatgtt tgagtcggca tttgacatct tcctactcat cagctatctg 2160
cttaacatcg ctgggcaggt taatatgtca cagcaagaca tatgcaagct acggcttgag 2220
ttgcttccaa tgatccaaga tattgtctca gagtggctca tcatcctttt ctttgttacc 2280
actccagctg agtcaacttc tatggaagat ttcagcttga aactttcatc tctacagatt 2340
gatagcagca ttgacaaaag atcatggaac gcaatgctag ggaaatgtgg tttctcactg 2400
gcgtttattc ttctctttag tgaccgaagt tgcattgtgg atggccgctt taacttgaga 2460
tatcttccga gttcacaaat cattacaagt ttggtgcaaa actttatcag ctggattcgg 2520
tatagtaaaa caggagatga ctcttcttca ctgctaagac gctccacgga acttagtctt 2580
aggttgattc ggaatggaca atctgatgct gttgagcgaa tccttgtggt tgtggaggca 2640
agtttacgtg gggagaaaac atttggatgt tctcaagata ctagtggaga ttggtgtctt 2700
cttcaacatc tccgtggttg ttgccttctt gatcaagtac aacgtggtgc aagtggcata 2760
ttaagagaga gaaagattat tgatgccatc cgctgcttct tcagagcttc atcaggtgaa 2820
ggatcttgga aggctttgca cagcttgtct aaagaagcag gattttcacc tgccacaacg 2880
ggtccaagta ttttagatgg ttctacgtct tctgcagcat ggaaacttca ttactatgag 2940
tgggctatgc aaatttttga acggtacaat ataagtgaag gagcttgtca gtttgcctat 3000
gcagcccttg agcaagtaga tgatgcctat aatttcatag agatgactga ggaattcgat 3060
ccaactaaag cagccaccta cactagagga cgactgtggg caaatgtttt caagttcacc 3120
ttagatctca atctcttgaa tgatgcctac tgtgctataa tttcaaaccc tgatgaggag 3180
attaagcgca tctgtttgag gcgcttcata atagttctat ttgaatgtgg caaaacgaag 3240
atcctcagtg atggacatct acctttcatc ggcttaacag agaagatcac ccaagagctt 3300
ttttggaagg ccggacgttc tgatataatg atgaagccaa atccatacaa gctgctttat 3360
gcttatgaga tgagacgaca caattggcga atggcggcaa gttacatgta tcagttttct 3420
gcccgtttga gaagcgaggg agcatgcaag gattacaaac acatgtccct agttttgcaa 3480
gagaggctta atggactttc tgctgctatg aatgcattag cccttgttca tcctgggtat 3540
gcttggattg atccagtacc agaagaaacc acacgttatc cggttaaaaa ggctagaaga 3600
gcagaagaag aacaattaag gagtaatgac cagcccaaag gggagaagag ttgcattgat 3660
atcgagaaac tccaaaacga gtttgttttt actactgctg aatatatgct ttctctgaaa 3720
aatttcgggt ggacatattc aggactcgaa aagccaccat cagatttggt tgaccttctt 3780
gtccaggcaa acttgtatga catggcattc actgttgttt tgaaattttg gaggggctcc 3840
gctttgaaaa gggagctgga aaagatattt gagaatatgg caattaaatg ttgccctgct 3900
aaaggaactc tgtggtcatc gcctaatctt atgttaacat ctaacgatga agaagttact 3960
cattcgcctg atagaagccc tgctgatcag ggctctaagt tggctggtga ttgggaaatt 4020
cttgaggttt atctgaagag gtacatagac atacacgcta gactaccggt ttctgttgct 4080
tcaacccttc ttcaagcaga ttcttgtatc gaattgcctc tctggctgat tcaaatgttc 4140
aaggatggtc agaaggaaaa agctttggga atggctgggc aagaagcaag tcctgcttcc 4200
ttgtttcagt tatatgttga ttatgggcgt cttacagagg caactaattt gctacttgag 4260
tacatggaat catttgcttc atcgaaacca gcagaggtat tgaagaggaa aaaggtatcc 4320
ggagtttggt ttccgtacac aacagtagaa agactatggt gggagctaga gaaaacaatg 4380
aactcaggac gaatggtgga gcaatgccat aagctgaagg aacaacttca tcatgcatta 4440
ctcaatcact taaaactgct taaggtggac tcaaatgatg ctgtatcctc tgcaaccggt 4500
taa 4503
<210> 27
<211> 3126
<212> DNA
<213> Arabidopsis thaliana
<400> 27
atgtttggct catctaatcc ttttggacag tcatctggta ccagcccatt tgggtctcaa 60
tctttgtttg gtcagaccag caatacaagt agtaataatc cctttgctcc agctacaccg 120
tttggcacgt ctgctccttt tgctgcacag tcgggaagtt caatattcgg aagcacttca 180
accggtgttt ttggtgcacc tcaaacatcc tctccctttg cctccacccc aacttttgga 240
gcttcttcat caccagcatt tgggaattct actccggcct ttggagcatc tccagcatct 300
tcaccttttg gtggatcttc tggttttggg cagaaacctt tgggattttc aacgcctcag 360
tcaaatcctt ttggaaactc cacgcagcaa tcccaacctg catttggaaa cacctctttt 420
ggttcgtcta caccttttgg tgccactaac acgcctgcct ttggcgctcc aagcacgcct 480
tcttttggcg ccacaagcac accctcgttt ggtgcatcaa gcacgcctgc ctttggtgcc 540
acaaacacgc ctgccttcgg tgcctcaaac tctccctcct ttggcgccac aaacacacct 600
gcatttggcg cgtcaccgac tccagctttt ggtagcactg gcaccacgtt tggtaacact 660
ggctttggtt ctggaggtgc ttttggagct tcaaacaccc ctgcttttgg tgcatcaggc 720
actccggctt ttggtgcatc aggcactcct gccttcggtg catcaagtac tcctgccttt 780
ggggcatcca gtactcctgc ctttggggca tccagtactc ctgcctttgg gggatctagt 840
actccttctt ttggtgcgtc aaatacctca tcctttagtt ttggctcgtc tccagctttt 900
ggccagtcta catcagcctt tggtagcagc gcctttggct ctacaccatc tccctttgga 960
ggtgcgcagg cttcaacccc tacatttggg ggttctggtt ttggtcaatc aactttcggt 1020
ggtcaacaag ggggcagtcg agctgtgcct tatgcaccaa ctgttgaggc agacacaggg 1080
accggcactc agcctgctgg aaagttggaa tctatttctg ccatgccagc atacaaagag 1140
aaaaactatg aggagctgag gtgggaagat taccagcgag gagataaagg tggaccactt 1200
cctgctggcc agtctcctgg caatgccgga tttggtatat caccttctca accaaatcca 1260
ttttctccat caccggcgtt tggtcagaca tcagcaaatc caacaaaccc tttttcgagc 1320
tcaacatcta ccaacccttt tgcccctcaa accccaacaa ttgctagttc gagttttgga 1380
acggctacct caaattttgg ttcctcgccc tttggtgtaa catcttcttc caatcttttt 1440
ggttcaggtt catcaactac cacatccgtt tttggatcat cctccgcttt tggaacaacg 1500
acaccatcac cgttatttgg ttcatcaagc actcctggat ttggctcttc ttcatcaatc 1560
tttggttcag ctcctggtca gggggcaact ccagcatttg gcaacagtca gccatctact 1620
ctgttcaatt caaccccttc gaccgggcag actggttctg cgtttggaca gactggttct 1680
gcttttggac agttcggaca gagtagtgct cctgcatttg gccaaaatag catttttaat 1740
aaaccttcca ctggatttgg aaacatgttt tccagttctt caacattaac cacgtctagc 1800
agctctccct ttggacaaac aatgcctgct ggtgtgacac cctttcaatc agctcagcca 1860
ggtcaagcat caaatggttt tggtttcaac aacttcggtc aaaatcaagc agctaatact 1920
actggaaatg ctggtggact ggggattttt ggtcaaggca acttcgggca atcgcctgct 1980
ccgctgaact ctgttgtttt gcaaccagtt gctgtgacaa acccatttgg aacacttcct 2040
gctatgcctc agatttcaat aaatcaaggt ggaaattcac cttccattca atatggaatc 2100
tccagcatgc ctgttgttga caaacctgct cctgttagaa tatcatctct cctgacttct 2160
cgacacctat tacacaggcg ggtcaggctg ccggcaagaa agtaccgtcc tggcgagaat 2220
ggtccaaagg ttccattttt cactgatgac gaagagagct caagtacacc aaaggcggat 2280
gctcttttca ttccaaggga gaaccctaga gctctagtta tacgcccagt tcaacagtgg 2340
tcttcaaggg ataaatcaat acttccaaag gaacaacgcc cgactgctcc attacatgac 2400
aatgggaaga gtcccgacat ggccactgat gcagcaaacc atgacagaaa tggtaacgga 2460
gaacttggtg ctactgggga aagaattcat acatcagtca atgcaaatca gaaaccgaat 2520
ggcacaacac gctcagatca ggctagcgag aaagagcgtc cctacaaaac tctaagtgga 2580
cacagagcag gagaagccgc aattgtttat gagcacggtg cagatatcga ggctcttatg 2640
ccgaagctac gacaatctga ttatttcaca gagccacgta tccaagaact agcagctaag 2700
gaaagagcgg atccgggtta ctgcaggcgg gtaagagact ttgtagtggg acgacacggt 2760
tatggtagca taaagttcat gggagagaca gatgtgcgta ggctagactt ggaatcactg 2820
gttcagttca atacacggga agtgattgta tacatggacg agagcaagaa accggctgtt 2880
gggcaaggtt tgaataaacc ggcggaagta acgttgctga acataaaatg tattgacaag 2940
aagacaggga aacagtttac tgaaggagag agagtggaga agtataagat gatgcttaag 3000
aagaaagctg aggcacaagg agctgagttt gtgtcatttg atccagtgaa aggcgaatgg 3060
aagtttcggg tcgagcattt tagttcgtat aagctgggcg acgaagatga agaagatgga 3120
gtttag 3126
<210> 28
<211> 2994
<212> DNA
<213> Arabidopsis thaliana
<400> 28
atgttcggtt cttctaataa taatcctttt ggacagtcat ctataagcag tccttttggg 60
acccaaactc attctttgtt cggacagacc aataataacg cgagcaataa tccttttgct 120
acgaaacctt ttggtacttc tactcctttt ggcgcacaga cagggagttc tatgtttggg 180
ggcacttcaa ctggtgtgtt tggtgcacct caaacttctt caccttttgg tgcttcacca 240
caagcgtttg ggagctctac tcaggctttt ggagcatctt ctaccccttc atttggcagt 300
tcaaattcac cttttggtgg cacctctacg tttggtcaga agtcttttgg cctctcaaca 360
cctcagtcaa gtccttttgg aagcaccaca caacaatcac agcctgcctt tggaaacagc 420
acttttggtt catcaacacc ttttggtgcc tcaaccacgc ctgcctttgg tgcctctagc 480
acgcctgcct ttggtgtctc aaacacttcc gggtttggag ccacaaacac acccggattt 540
ggtgccacaa acacaacagg gtttggtggc agtagcacac ctgggtttgg ggcatcaagc 600
acgcctgcct ttggctccac aaacacgcct gcttttggtg cttcaagtac tcctttattc 660
ggctcctcga gctcacctgc atttggtgcg tcacctgctc cagcctttgg tagctctggc 720
aatgcatttg gcaacaatac cttcagttct ggaggtgctt ttggttcatc aagcactcct 780
acgtttgggg catctaacac ttctgccttt ggggcatcaa gttccccatc ttttaatttc 840
ggttcttccc cagcttttgg acagtctacc tcagcatttg gtagcagttc ctttggttct 900
acacaatctt ccttaggttc tacaccatct cccttcggag cccaaggtgc acaggcttcg 960
acttcaacat ttgggggtca atcaactatc gggggtcaac aaggggggag tagggttatt 1020
ccttatgcac ctacaactga cacagcgtca ggcactgaaa gcaagtctga aagactacaa 1080
tctatatctg ccatgcctgc acacaaaggg aaaaacatgg aggagcttag gtgggaggac 1140
taccagcgag gagataaagg aggacaacgt tctactggtc aatctcctga aggtgctgga 1200
tttggtgtaa caaattctca gccaagtata ttctctacgt caccagcgtt tagccagaca 1260
cctgtgaatc caacaaaccc tttttcacag acgactccaa caagtaacac aaatttttcc 1320
ccctccttta gtcaacccac taccccatcc tttggtcaac ccactacccc atcctttagg 1380
tcaactgtat caaatactac atccgttttt ggatcatcct ctagtttaac aacaaacaca 1440
tcgcagccac ttggttcatc aatatttggt tctactcctg cacatgggtc aactccagga 1500
tttagcattg gtggatttaa caacagtcag tcatctccgc tgtttggttc aaacccctca 1560
tttgcacaaa ataccactcc tgcattcagc cagactagtc ctttgtttgg acagaatacc 1620
actcctgcat taggacagtc tagttctgtg tttggacaga ataccaatcc tgcacttgta 1680
cagagcaaca ctttcagtac accttccact ggctttggga acacgttttc aagctcttca 1740
tccttaacta caagcatctc cccctttggt caaataacgc ctgctgttac gccctttcaa 1800
tcagctcagc caactcaacc attaggtgct tttggtttca acaactttgg tcaaacccaa 1860
atagctaata caactgacat tgcaggtgca atgggaactt ttagccaagg aaactttaag 1920
caacagcctg cattgggtaa ctctgctgtt atgcaaccaa ctcctgttac aaacccattt 1980
ggaacacttc ctgctttgcc tcagatttca attgctcaag gtggaaattc accttcgatt 2040
cagtatggta tctccagcat gcctgtcgtt gataagcctg ctcctgttag agtatcacca 2100
ctcctaactt ctcgacacct tttacaaagg cgggtcaggc taccaacaag aaagtaccgt 2160
cctagtgatg atggtccaaa ggttccattc ttcagcgatg aagaggagaa ttccagtaca 2220
ccaaaggctg atgcgttttt cattccaagg gagaacccta gagctttatt tatacgccca 2280
gttgaaaggg taaaatcaga acatccaaag gatagcccga ccccactgca ggagaacggt 2340
aagaggtcga atggggttac taatggagcc aaccatgaga ctaaggataa cggtgcaatt 2400
cgtgaagctc ccccggtaaa agtcaatcag aaacagaacg ggacacatga aaatcacgga 2460
ggcgacaaaa acggttcaca cagttcacca agtggagcag atattgagtc attaatgccg 2520
aagttgcatc actctgaata tttcacagag cctcggatcc aagaactggc tgcaaaagaa 2580
agggttgaac agggttattg caagcgggta aaggactttg ttgttgggag acacggttac 2640
gggagcataa agtttctagg agagacggat gtgtgtagac tcgacctgga aatggtggtt 2700
cagttcaaaa accgggaagt gaatgtgtac atggacgaga gcaaaaaacc gccggtgggt 2760
caaggattga ataagcctgc ggtggtaact ttgctgaaca taaaatgtat ggacaagaag 2820
accggcacgc aagtgatgga aggcgagaga ttggacaagt acaaggaaat gctcaagagg 2880
aaagctgggg aacaaggagc tcagtttgtg tcttatgatc ctgtgaatgg cgagtggact 2940
ttcaaggtcg aacatttcag ttcctacaag cttggagatg aatatgatgt gtag 2994
Claims (10)
- 애기장대 유래 PRR9/7/5(Pseudo Response Regulator9/7/5), CCA1/LHY(Circadian Clock-Associated 1/Late Elongated Hypocotyl), FIP37(FKBP12 Interacting Protein 37), CML10(Calmodulin-Like Protein), PDAT1(Phospholipid:Diacylglycerol Acyltransferase 1), SKM1/2(Sterility Rugulating Kinase Member1/2), CRY1(Cryptochrome 1), NUP160(Nucleoporin 160) 또는 NUP98a1/b1(Nucleoporin 98a1/b1) 단백질을 코딩하는 유전자의 발현을 식물세포에서 조절하는 단계를 포함하는, 식물체의 재분화(regeneration) 효율을 조절하는 방법.
- 제1항에 있어서, 상기 PRR9/7/5 단백질은 각각 순서대로 서열번호 1 내지 3의 아미노산 서열로 이루어진 것이고, 상기 CCA1/LHY 단백질은 각각 서열번호 4 또는 5의 아미노산 서열로 이루어진 것이고, 상기 FIP37 단백질은 서열번호 6의 아미노산 서열로 이루어진 것이고, 상기 CML10 단백질은 서열번호 7의 아미노산 서열로 이루어진 것이고, 상기 PDAT1 단백질은 서열번호 8의 아미노산 서열로 이루어진 것이고, 상기 SKM1/2 단백질은 각각 서열번호 9 또는 10의 아미노산 서열로 이루어진 것이고, 상기 CRY1 단백질은 서열번호 11의 아미노산 서열로 이루어진 것이고, 상기 NUP160 단백질은 서열번호 12의 아미노산 서열로 이루어진 것이며, 상기 NUP98a1/b1 단백질은 각각 서열번호 13 또는 14의 아미노산 서열로 이루어진 것을 특징으로 하는 식물체의 재분화 효율을 조절하는 방법.
- 제1항에 있어서, 상기 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자의 발현을 식물세포에서 저해시켜 야생형 식물체에 비해 식물체의 재분화 효율을 감소시키는 것을 특징으로 하는 식물체의 재분화 효율을 조절하는 방법.
- 제1항에 있어서, 상기 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자의 발현 저해는 VIGS (Virus-induced gene silencing), RNAi 또는 안티센스 RNA, T-DNA 삽입, 내생 트랜스포존(transposon), 방사선 조사 또는 유전자 교정 시스템을 통한 돌연변이 유발을 이용하여 발현을 저해하는 것을 특징으로 하는 식물체의 재분화 효율을 조절하는 방법.
- 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자를 포함하는 재조합 벡터로 식물세포를 형질전환하는 단계를 포함하는, 재분화 효율이 조절된 형질전환 식물체의 제조방법.
- 제5항에 있어서, 상기 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자의 발현을 식물세포에서 저해시켜 야생형에 비해 식물체의 재분화 효율이 감소된 것을 특징으로 하는 형질전환 식물체의 제조방법.
- 제5항 또는 제6항의 방법에 의해 제조된 재분화 효율이 조절된 형질전환 식물체.
- 제7의 식물체의 형질전환된 종자.
- 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자의 발현이 저해되어, 야생형에 비해 재분화 효율이 감소된 돌연변이 식물체.
- 애기장대 유래 PRR9/7/5, CCA1/LHY, FIP37, CML10, PDAT1, SKM1/2, CRY1, NUP160 또는 NUP98a1/b1 단백질을 코딩하는 유전자를 유효성분으로 포함하는, 식물체의 재분화 효율 조절용 조성물.
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