KR20230137615A - A device that automatically synthesizes a compound and a method of synthesizing a compound using the same - Google Patents

Abstract

One embodiment of the present invention provides a technology for simultaneously producing many types of compounds on a small scale in one device. A fully automatic compound synthesis device according to an embodiment of the present invention comprises: a reaction unit including at least one reaction chamber providing a reaction space; a temperature control unit controlling the temperature of the reaction chamber; an injection unit injecting a fluid into the reaction chamber; and a magnetic field application unit providing the magnetic field to magnetic particles contained in the fluid and performing movement.

Description

Fully automatic compound synthesis device and compound synthesis method using the same {A DEVICE THAT AUTOMATICALLY SYNTHESIZES A COMPOUND AND A METHOD OF SYNTHESIZING A COMPOUND USING THE SAME}

The present invention relates to a fully automatic compound synthesis device and a compound synthesis method using the same, and more specifically, to a technology for simultaneously producing many types of compounds on a small scale in one device.

In a situation where the need for rapid development of new drugs is emerging to minimize human and material losses due to infectious disease epidemics, and the field of new drug development at home and abroad is rapidly developing, the microfluidic reactor-based fully automatic compound synthesizer is an automated equipment for manpower saving and rapid synthesis. It is a technology and an equipment technology that allows precise chemical reaction control.

Existing chemical compound synthesis automation equipment is capable of synthesizing one compound at a time through a predetermined chemical process, and is difficult to apply in the time-consuming early discovery stage of new drug development. Accordingly, there is a need to develop technology to simultaneously produce many types of small-scale compounds that can perform drug efficacy evaluation.

In U.S. Patent No. 7,988,913 (title of the invention: Biochemical reaction cartridge), a plurality of chambers are formed and each chamber is connected by a flow path, and when a material is injected into the flow path, magnetic particles are injected, and these magnetic particles Controlling moving substances by providing a magnetic field, and each chamber is filled with different substances, and after dissolution of cells, substances such as DNA attached to magnetic particles are transferred to each chamber using magnetic force. The matter of allowing the reaction to be carried out while moving is disclosed.

In U.S. Patent Publication No. 2017-0128927 (title of the invention: Method for self-regulation of a system), a plurality of spaces in which fluid flows or is stored are formed, and a configuration that provides magnetic force is formed in each space, and the magnetic force It is disclosed that each magnet is fixedly formed adjacent to a space or flow path and that the magnetic force is controlled to control the particles.

In the above-described prior art techniques, there is a limitation in synthesizing multiple compounds, so there is a problem in that they are unsuitable for producing many types of compounds on a small scale at the same time.

US Patent No. 7,988,913 US Patent Publication No. 2017-0128927

The purpose of the present invention to solve the above problems is to provide a technology for simultaneously producing many types of compounds on a small scale in one device.

And, the purpose of the present invention is to enable the simultaneous synthesis of multiple compounds as described above to be performed fully automatically.

The technical problem to be achieved by the present invention is not limited to the technical problem mentioned above, and other technical problems not mentioned can be clearly understood by those skilled in the art from the description below. There will be.

The configuration of the present invention for achieving the above object includes a reaction unit having at least one reaction chamber providing a reaction space; a temperature control unit that controls the temperature of the reaction chamber; an injection unit that injects fluid into the reaction chamber; and a magnetic field application unit that provides a magnetic field to the magnetic particles contained in the fluid and performs movement, wherein one reaction chamber and the other reaction chamber are connected to each other by a flow path, and the magnetic particles move by the movement of the magnetic field application unit. and the magnetic particles are vibrated by controlling the magnetic field of the magnetic field application unit.

In an embodiment of the present invention, the fluid stored in one injection portion of the plurality of injection portions may flow to the one reaction chamber, and the fluid stored in the other injection portion may flow to the other reaction chamber.

In an embodiment of the present invention, the reaction unit includes a reaction body with the reaction chamber formed therein; And a connection channel, which is a flow path connecting one reaction chamber to another reaction chamber, may be further provided.

In an embodiment of the present invention, the reaction unit includes an injection channel formed in the reaction body and providing a flow path for fluid flowing from the injection unit to the reaction chamber; a collecting channel formed in the reaction body and collecting liquid discharged after reaction in the reaction chamber; and a discharge channel formed in the reaction body and providing a flow path for fluid flowing from the reaction chamber to the collecting channel.

In an embodiment of the present invention, the reaction unit may further include a dispensing body that is coupled to the reaction body and dispenses the reaction product discharged from the reaction body to the outside.

In an embodiment of the present invention, one portion is coupled to the injection unit and the other portion is coupled to the reaction portion, and may further include a distribution portion that delivers fluid from the injection portion to the reaction portion.

In an embodiment of the present invention, the distribution unit includes a distribution channel connected to the injection unit and providing a flow path for the fluid; and a distribution outlet that discharges the fluid that has passed through the distribution channel.

In an embodiment of the present invention, the distribution unit includes a fluid control body that has a fluid pipe formed in the shape of a pipe and a support plate for supporting the fluid pipe and performs three-dimensional movement; and a selective distributor that performs three-dimensional movement and rotation to selectively connect to the fluid pipe and receives the fluid that has passed through the fluid pipe.

In an embodiment of the present invention, a storage tray having a plurality of wells, which is a space for storing reaction products discharged from the reaction unit, may be further included.

In an embodiment of the present invention, the tray drive unit may further include a tray drive unit coupled to the storage tray and moving the storage tray.

In an embodiment of the present invention, the injection unit may include a reservoir that stores fluid and supplies the fluid to the reaction unit; and an injector coupled to the reservoir and providing pressure to the fluid in the reservoir.

In an embodiment of the present invention, the temperature control unit includes a temperature controller that heats or cools the reaction chamber; and a controller support body that is coupled to the temperature controller and supports the temperature controller.

In an embodiment of the present invention, the magnetic field moving part that moves the magnetic field applying part moving along the direction in which each of the plurality of reaction chambers is arranged may be further included.

In an embodiment of the present invention, a control unit that transmits a control signal to the magnetic field application unit, the injection unit, or the temperature control unit may be further included.

The configuration of the present invention to achieve the above object includes: a first step in which a user inputs information about a reaction product into the control unit; A second step in which the magnetic particles and the first sample are injected into a first reaction chamber among a plurality of reaction chambers, and the material in the first sample is attached to the magnetic particles; As the magnetic particles discharged from the first reaction chamber due to the movement of the magnetic field application unit sequentially pass through a plurality of other reaction chambers connected to the first reaction chamber, the magnetic particles are stored in one of the plurality of reaction chambers. A third step in which the material attached to and the material in one sample supplied to the one reaction chamber are synthesized; and a fourth step in which the reaction product is discharged from the reaction unit and the reaction product is stored in a well of a storage tray.

The configuration of the present invention for achieving the above object includes a reaction unit having at least one reaction chamber providing a reaction space; a temperature control unit that controls the temperature of the reaction chamber; an injection unit that injects fluid into the reaction chamber; and a magnetic field application unit that provides a magnetic field to the compound generated in the reaction chamber and performs movement, wherein one reaction chamber and the other reaction chamber are connected to each other by a flow path, and the compound moves by the movement of the magnetic field application unit. The particles of the compound are vibrated by controlling the magnetic field of the magnetic field application unit, the fluid stored in one injection part among the plurality of injection parts flows into the one reaction chamber, and the fluid stored in the other injection part reacts with the other reaction chamber. It is characterized by flowing into the chamber.

The configuration of the present invention to achieve the above object includes a first step in which the user inputs information about the reaction product into the control unit; A second step in which a sample is injected into a first reaction chamber among a plurality of reaction chambers and a reaction is performed in the first reaction chamber to produce a compound; The compound discharged from the first reaction chamber sequentially passes through a plurality of other reaction chambers connected to the first reaction chamber, and the compound flows into the one reaction chamber within one of the plurality of reaction chambers. A third step in which materials in the sample supplied to the one reaction chamber are synthesized; and a fourth step in which the reaction product is discharged from the reaction unit and the reaction product is stored in a well of a storage tray.

The effect of the present invention according to the above configuration is that the synthesis device can operate fully automatically to synthesize compounds. Accordingly, various types of compounds can be synthesized quickly, significantly reducing the time and cost required for compound synthesis. That means you can save money.

In addition, the effect of the present invention is to perform DNA synthesis, protein synthesis, and other chemical synthesis, and to produce new drug candidates through modularization and automation of key chemical processes mainly used in compound synthesis. This means that compound synthesis can be performed quickly and at low cost.

The effects of the present invention are not limited to the effects described above, and should be understood to include all effects that can be inferred from the configuration of the invention described in the detailed description or claims of the present invention.

Figures 1 and 2 are perspective views of a synthesis device according to an embodiment of the present invention.
Figure 3 is a perspective view of the internal structure of a synthesis device according to an embodiment of the present invention.
Figure 4 is a perspective view of an injection module according to an embodiment of the present invention.
Figure 5 is a schematic diagram of a distribution unit according to another embodiment of the present invention.
Figure 6 is a perspective view of a reaction unit and a temperature control unit according to an embodiment of the present invention.
Figure 7 is a partial enlarged view of a combination of a reaction unit and a temperature control unit according to an embodiment of the present invention.
Figure 8 is a schematic diagram of whether or not a magnetic field is applied according to an embodiment of the present invention.
Figure 9 is a side view of the internal configuration of a synthesis device according to an embodiment of the present invention.
Figure 10 is a schematic diagram of a portion of a synthesis device and a storage tray according to an embodiment of the present invention.

Hereinafter, the present invention will be described with reference to the attached drawings. However, the present invention may be implemented in various different forms and, therefore, is not limited to the embodiments described herein. In order to clearly explain the present invention in the drawings, parts that are not related to the description are omitted, and similar parts are given similar reference numerals throughout the specification.

Throughout the specification, when a part is said to be "connected (connected, contacted, combined)" with another part, this means not only "directly connected" but also "indirectly connected" with another member in between. "Includes cases where it is. Additionally, when a part is said to “include” a certain component, this does not mean that other components are excluded, but that other components can be added, unless specifically stated to the contrary.

The terms used in this specification are merely used to describe specific embodiments and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as “comprise” or “have” are intended to indicate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are not intended to indicate the presence of one or more other features. It should be understood that this does not exclude in advance the possibility of the existence or addition of elements, numbers, steps, operations, components, parts, or combinations thereof.

Hereinafter, a synthesis device according to an embodiment of the present invention will be described in detail with reference to the attached drawings.

Figures 1 and 2 are perspective views of a synthesis device according to an embodiment of the present invention, and Figure 3 is a perspective view of the internal configuration of the synthesis device according to an embodiment of the present invention.

Figure 4 is a perspective view of an injection module according to an embodiment of the present invention, Figure 5 is a schematic diagram of the distribution unit 400 according to another embodiment of the present invention, and Figure 6 is a reaction according to an embodiment of the present invention. This is a perspective view of the temperature control unit and the temperature control unit. And, Figure 7 is a partial enlarged view of the combination of the reaction unit 100 and the temperature control unit 820 according to an embodiment of the present invention.

FIG. 8 is a schematic diagram of the magnetic field application unit 210 according to an embodiment of the present invention, FIG. 9 is a side view of the internal configuration of a synthesis device according to an embodiment of the present invention, and FIG. 10 is a schematic diagram of the magnetic field application unit 210 according to an embodiment of the present invention. This is a schematic diagram of a portion of the synthesis device and the storage tray 610 according to an embodiment.

As shown in Figures 1 to 10, the synthesis apparatus of the present invention includes a reaction unit 100 having at least one reaction chamber providing a reaction space; A temperature control unit 820 that controls the temperature of the reaction chamber; An injection unit 300 that injects fluid into the reaction chamber; and a magnetic field application unit 210 that provides a magnetic field to the magnetic particles contained in the fluid and performs movement.

In addition, the synthesis device of the present invention has an internal space and includes a reaction unit 100, an injection unit 300, a temperature control unit 820, a magnetic field application unit 210, a guide unit, and a storage tray 610. It may further include a housing 810 in which to position.

An injection module may be formed in the upper part of the internal space of the housing 810, and a plurality of injection units 300 may be combined to form one injection module. Here, the injection unit 300 includes a reservoir 320 that stores fluid and supplies the fluid to the reaction unit 100; and an injector 310 that is coupled to the storage tank 320 and provides pressure to the fluid in the storage tank 320.

The storage tank 320 may be formed in the shape of a barrel with a circular or polygonal cross-section, and an outlet of the storage tank 320 through which fluid is discharged may be formed at the bottom of the storage tank 320, and each of the plurality of storage tanks 320 may have an outlet. The same or different fluids may be stored respectively.

In addition, the injector 310 is formed in close contact with the inner surface of the storage tank 320 and includes a pressurizing body 312 that pressurizes the fluid, and an actuator 311 that provides force to move the pressurizing body 312 and has a variable length. And, it may be provided with a push bar 313, one end of which is coupled with the actuator 311 and the other end of which is coupled with the pressurizing body 312. In addition, an injection support frame 330 may be formed on the upper part of the storage tank 320 and supports the actuator 311.

The injection support frame 330 may have a side wall that is partially open so that the upper wall, lower wall, and actuator 311 can be seen, and the pusher 313 penetrates the lower wall of the injection support frame 330. Thus, the actuator 311 and the pressurizing body 312 can be connected. The pressurizing body 312 may be formed in a shape corresponding to the cross-sectional shape of the storage tank 320 and can seal the internal space of the storage tank 320 filled with fluid.

When the actuator 311 operates and the length of the actuator 311 increases, the pusher 313 moves downward and the pressurizing body 312 pressurizes the fluid, and accordingly, the fluid stored in the storage tank 320 flows into the storage tank 320. ) can be discharged through the storage tank outlet.

The synthesis device of the present invention has one part coupled to the injection unit 300 and the other part coupled to the reaction unit 100, and a distribution unit 400 that transfers the fluid from the injection unit 300 to the reaction unit 100. ) may further be included. In addition, inside the distribution unit 400, a plurality of distribution channels (first distribution channel, ..., nth distribution channel) may be formed to provide a flow path for the fluid, and one end of the distribution channel is the injection section ( It can be connected to the storage tank outlet of 300).

The distribution unit 400 may be provided with a plurality of distribution outlets, and specifically, it may be provided with a first distribution outlet, a second distribution outlet, ..., an nth distribution outlet as the outlet. Additionally, one distribution outlet may be connected to each other end of at least one distribution channel, and accordingly, fluid from at least one injection unit 300 may be discharged through one distribution outlet.

As a specific example, a first distribution channel connected to the first injection unit 300 among a plurality of injection units 300 (first injection unit, ..., n-th injection unit), a second injection unit 300 The other ends of each of the second distribution channel connected to and the third distribution channel connected to the third injection unit 300 may be connected to the first distribution outlet. Additionally, the other end of the sixth distribution channel connected to the sixth injection unit 300 may be connected to the second distribution outlet.

In addition, the fluid discharged from the first injection unit 300, the fluid discharged from the second injection unit 300, or the fluid discharged from the third injection unit 300 is discharged through the first distribution outlet to form the reaction unit 100. ), and the fluid discharged from the sixth injection unit 300 may be discharged through the second distribution outlet and delivered to the reaction unit 100. The connection between the injection unit 300, the distribution channel, and the distribution outlet as described above can be formed in various ways.

The fluid stored in one of the plurality of injection units 300 may flow to one reaction chamber, and the fluid stored in the other injection unit 300 may flow to the other reaction chamber. Additionally, one reaction chamber and another reaction chamber may be connected to each other by a flow path.

Specifically, the reaction unit 100 includes a reaction body 101 with a reaction chamber formed therein; And a connection channel, which is a flow path connecting one reaction chamber to another reaction chamber, may be further provided. The reaction body 101 may be made of a transparent material, and therefore, it may be easy to visually check the fluid flowing through the inside of the reaction body 101.

In addition, the reaction unit 100 includes an injection channel formed in the reaction body 101 and providing a flow path for the fluid flowing from the injection unit 300 to the reaction chamber; A collection channel 170 formed in the reaction body 101 and collecting liquid discharged after reaction in the reaction chamber; And it may further include a discharge channel formed in the reaction body 101 and providing a flow path for the fluid flowing from the reaction chamber to the collection channel 170.

The reaction chamber may be formed of a plurality of reaction chambers (first reaction chamber 111, ..., n-th reaction chamber), and each reaction chamber may be connected by a connection channel. Accordingly, there may be a plurality of connection channels. It may be formed as (first connection channel 131, ..., nth connection channel).

Since the reaction chamber is formed as a plurality as described above, a plurality of injection channels can be formed (the first injection channel 121, ..., the nth injection channel), and a plurality of discharge channels can also be formed (the first discharge channel). (141), ..., nth discharge channel), one end of each discharge channel may be connected to the reaction chamber, and the other end of the discharge channel may be connected to the collection channel 170.

The reaction chamber may be connected to at least one injection channel. As a specific example, as shown in FIGS. 3, 5, and 7, two injection channels are connected to the uppermost reaction chamber to which fluid is first supplied. One injection channel may be connected to the remaining reaction chamber.

In addition to the discharge channels described above, a delivery channel 150, which is a flow path for transferring the reaction products inside the reaction chamber to the dispenser 500, may be formed in the lowest reaction chamber where the reaction products are discharged.

Design details for the synthesis device of the present invention, such as the arrangement design of the channel formed in the reaction unit 100, can be formed in various ways. Hereinafter, in the embodiment of the present invention, as shown in FIGS. 1 to 8, 4 It is provided with a first reaction chamber 111, a second reaction chamber 112, a third reaction chamber 113, and a fourth reaction chamber 114 as reaction chambers, and five injection parts 300 are used for one injection. The description will be based on the synthesis device of the present invention, which forms a set and five injection sets form one injection module. However, the injection set may include at least one injection unit 300 and is not limited as described above.

Twenty-five injection units 300 (first to 25th injection units) can be formed from the plurality of injection units 300, with the first to fifth injection units forming the first injection set, and the sixth to fifth injection units forming the first injection set. The tenth injection unit may form a second injection set, and the eleventh to fifteenth injection units may form a third injection set. Likewise, the 16th to 20th injection parts may form a fourth injection set, and the 21st to 25th injection parts may form a fifth injection set.

In the distribution unit 400, a first distribution channel connected to the first injection unit is formed, so that 25 distribution channels (first to 25th distribution channels) connected to each injection unit 300 are formed. The distribution unit 400 may be provided with five distribution outlets (first to fifth distribution outlets).

The first to fifth distribution channels may be connected to the first distribution outlet, the sixth to tenth distribution channels may be connected to the second distribution outlet, and the eleventh to fifteenth distribution outlets may be connected to the third distribution outlet. Additionally, the 16th to 20th distribution outlets may be connected to the fourth distribution outlet, and the 21st to 25th distribution outlets may be connected to the fifth distribution outlet.

Accordingly, the fluid discharged from each injection part 300 of the first injection set may be discharged through the first distribution outlet, and the fluid discharged from each injection part 300 of the second injection set may be discharged from the second injection set. It can be discharged through the distribution outlet. In the same principle, the fluid discharged from each of the third to fifth injection sets may be discharged through the third to fifth distribution outlets.

However, the configuration of the distribution unit 400 is not limited to each of the distribution channels and distribution outlets fixed inside the distribution unit 400 as described above, and other structures may be formed inside the distribution unit 400. Of course it exists.

Specifically, as shown in Figure 5, the distribution unit 400 is provided with a fluid pipe 412 formed in the shape of a pipe and a support plate 411 for supporting the fluid pipe 412 and performs three-dimensional movement. Fluid control body 410; And it may include a selective distributor 420 that is selectively connected to the fluid pipe 412 by performing three-dimensional movement and rotation and receives the fluid that has passed through the fluid pipe 412.

The fluid pipes 412 may be formed in a 3X5 arrangement, but this is not limited, and the number of fluid pipes 412 may be increased or subtracted. By moving the support plate 411, one fluid pipe 412 can be connected to the reservoir 320 of one injection unit 300, and the fluid discharged from the reservoir 320 can pass through the fluid pipe 412. You can.

In addition, the fluid that has passed through the fluid pipe 412 may pass through the selective distributor 420 and then be injected into an injection channel selected from the first to fifth injection channels 121 to 125.

The selective distribution body 420 includes a distribution pipe 421 that performs three-dimensional movement and rotation in the shape of a pipe; A connection pipe 422 formed to be spaced apart from the distribution pipe 421 and selectively connected to the fluid pipe 412 in the shape of a pipe; One end is coupled to the distribution pipe 421 and the other end is coupled to the connection pipe 422 to provide a delivery pipe 423 that flows into the connection pipe 422 and flows into the distribution pipe 421. You can.

The three-dimensional position of the connection pipe 422 changes due to the position movement and rotation of the distribution pipe 421, and accordingly, the connection pipe 422 is selectively connected to the fluid pipe 412 to form the fluid pipe 412. The fluid that has passed through can be delivered.

In FIG. 5 , a plurality of connectors 422 are expressed as if they are arranged in a circle to represent the rotation of the connectors 422. As described above, the configuration of the distribution unit 400 can be formed in various ways, and the configuration can be selected depending on the purpose.

Among the four reaction chambers described above, the first reaction chamber 111 is located close to the top of the reaction body 101, and in the direction from the top to the bottom of the reaction body 101, the first reaction chamber 111, the second reaction chamber 111 The reaction chamber 112, the third reaction chamber 113, and the fourth reaction chamber 114 may be arranged sequentially.

In addition, the first reaction chamber 111 and the second reaction chamber 112 are connected by a first connection channel 131, and the second reaction chamber 112 and the third reaction chamber 113 are connected by a second connection channel. It is connected by 132, and the third reaction chamber 113 and the fourth reaction chamber 114 may be connected by a third connection channel 133.

In addition, the first reaction chamber 111 and the first distribution outlet are connected by the first injection channel 121, and the first reaction chamber 111 and the fifth distribution outlet are connected by the fifth injection channel 125. You can. And, the second reaction chamber 112 and the second distribution outlet are connected by the second injection channel 122, and the third reaction chamber 113 and the third distribution outlet are connected by the third injection channel 123. The fourth reaction chamber 114 and the fourth distribution outlet may be connected by the fourth injection channel 124.

As shown in FIGS. 3, 6, and 7, the first to fourth injection channels 124 may be formed on the left side of the reaction body 101, and the collection channel 170 may be formed on the right side of the reaction body 101. It may be formed extending from the top of the reaction body 101 toward the bottom.

In addition, the first reaction chamber 111 and the collection channel 170 may be connected by the first discharge channel 141, and the second reaction chamber 112 and the collection channel 170 may be connected to the second discharge channel 142. It can be connected by, and the third reaction chamber 113 and the collection channel 170 can be connected by the third discharge channel 143. Additionally, the fourth reaction chamber 114 and the collection channel 170 may be connected by a fourth discharge channel 144.

A valve may be formed in each of the injection channel, connection channel, discharge channel, and delivery channel 150, and the flow path formed in each channel may be opened and closed by such a valve. As a space formed inside the reaction body 101 to be connected to the flow path by the injection channel, connection channel, discharge channel, or delivery channel 150, left and right holes may be formed on both sides of the flow path.

The valve includes a left actuator (160a) that is formed to partially or entirely enter the left hole and operates by being guided to the left hole, and a right actuator that is formed to partially or fully enter the right hole and operates by being guided to the right hole. (160b) may be provided.

The left operating body 160a may be formed in a shape corresponding to the inner space of the left hole, and the right operating body 160b may be formed in a shape corresponding to the inner space of the right hole. The left operating body 160a and the right operating body may be formed in a shape corresponding to the inner space of the right hole. (160b) Each may be equipped with an electromagnet. Additionally, a case may be formed to surround the outside of the electromagnet.

When the first current is provided to each of the left actuator (160a) and the right actuator (160b), the left actuator (160a) and the right actuator (160b) have different polarities, so that the left actuator (160a) and the right actuator (160a) The sieves 160b may be combined by manpower to close the flow path.

And, when the direction of the current supplied to the left actuating element 160a changes to the opposite direction and the direction of the current supplied to the right actuating element 160b changes to the opposite direction, the left actuating element 160a and the right actuating element 160b The left operating body 160a and the right operating body 160b are spaced apart by repulsive force due to the floating of the same polarity, thereby opening the flow path.

A wire is coupled to each of the left actuator (160a) and the right actuator (160b), and this wire penetrates the reaction body 101 or is formed along the outer surface of the reaction body 101 to form a left actuator (160a). ) or can be connected to the right operating body (160b). (However, each wire is not shown.)

The valve formed in the injection channel is called an injection valve, the valve formed in the connection channel is called a connection valve, the valve formed in the discharge channel is called a discharge valve, and the valve formed in the delivery channel 150 can be called a delivery valve 164. there is.

Specifically, the first injection channel 121 has a first injection valve, the second injection channel 122 has a second injection valve, the third injection channel 123 has a third injection valve, and the fourth injection channel 124 has a third injection valve. A fifth injection valve may be formed in the fourth and fifth injection channels 125.

In addition, the first connection channel 131 has a first connection valve 161, the second connection channel 132 has a second connection valve 162, and the third connection channel 133 has a third connection valve 163. can be formed.

In addition, the first discharge channel 141 has a first discharge valve, the second discharge channel 142 has a second discharge valve, the third discharge channel 143 has a third discharge valve, and the fourth discharge channel 144 has a third discharge valve. 4 A discharge valve may be formed. In addition, a collection valve, which is a valve, may be formed at the lower part of the collection channel 170. (However, each injection valve, discharge valve, and collection valve are not shown.)

The reaction unit 100 may further include a dispensing body 500 that is coupled to the reaction body 101 and dispenses the reaction product discharged from the reaction body 101 to the outside. The dispenser 500 may be coupled to the lower end of the reaction body 101. In addition, the dispensing body 500 may be provided with a dispensing channel 510 that penetrates the dispensing body 500 and is connected to the delivery channel 150 to provide a flow path for the reaction product passing through the delivery channel 150. You can.

As described above, a predetermined process (reaction) is performed in each reaction chamber, and the final process is performed in the last reaction chamber, that is, the fourth reaction chamber 114, to produce a reaction product.

In addition, the reaction product generated in the fourth reaction chamber 114 flows along the delivery channel 150 by opening the closed delivery valve 164, and then flows through the dispensing channel 510 of the dispensing body 500. It can be dispensed to the outside of the dispensing body 500.

The synthesis apparatus of the present invention may further include a storage tray 610 having a plurality of wells, which is a space for storing reaction products discharged from the reaction unit 100. In addition, the composition device of the present invention may further include a tray driving part 620 that is coupled to the storage tray 610 and moves the storage tray 610.

As described above, the reaction body 101 may be formed in a shape in which fluid flows along a vertical direction, that is, a direction perpendicular to the ground (z-axis direction), and a storage tray formed at the lower portion of the dispensing body 500. 610 can move along the horizontal direction (x, y axis direction) parallel to the ground by the tray driving unit 620.

The storage tray 610, in which one of the plurality of wells stores the reaction product dispensed from the dispensing body 500, moves its position, and by placing the other well below the outlet of the dispensing channel 510, the other well is moved. Reaction results can be stored in the well.

The tray drive unit 620 includes a drive unit case 623 formed in the lower portion of the internal space of the housing 810; A forward and backward driving body 621 formed inside the driving case 623, coupled to the storage tray 610, and moving the storage tray 610 along the y-axis direction, which is the forward and backward direction; And it may be provided with a left and right driving body 622 that is coupled to the front and rear driving body 621 and moves the front and rear driving body 621 in the left and right x-axis direction.

Here, the front and rear driving bodies 621 or the left and right driving bodies 622 may be formed as linear motors. However, it is not limited to this, and of course other devices can be used.

As shown in FIG. 2, when a plurality of storage trays 610 are formed by forming a plurality of reaction parts 100, a plurality of forward and backward driving bodies 621 may be formed. In addition, the plurality of front and rear driving bodies 621 may be coupled to the left and right driving bodies 622, and position movement in the x-axis direction for each of the plurality of front and rear driving bodies 621 may be performed.

The temperature control unit 820 includes a temperature controller 710 that heats or cools the reaction chamber; And a controller support body 720 may be provided in combination with the temperature controller 710 to support the temperature controller 710. The regulator support 720 may be located at the rear of the reaction body 101, and a temperature controller 710 may be formed in the regulator support 720 at a position corresponding to each of the plurality of reaction chambers. Accordingly, temperature control can be performed separately for each of the plurality of reaction chambers.

The temperature controller 710 may have various configurations for temperature control, such as a Peltier element, a heat exchanger through which fluid for heating or cooling passes, and a heating coil for heating. The temperature within the reaction chamber can be varied within the temperature range of -75 to 150°C by the temperature controller 710.

The reaction chamber may be formed in a circular cross-section with respect to a plane perpendicular to the y-axis direction, and the magnetic field applying unit 210 may be formed in a cylindrical shape so that the rear surface of the magnetic field applying unit 210 facing the reaction chamber is circular. You can. However, it is advantageous for the magnetic field application unit 210 to be formed in a shape corresponding to the reaction chamber, but is not limited thereto.

As described above, the fifth injection channel 125, which is a passage having a larger passage cross-sectional area than the passage cross-sectional area of the first to fourth injection channels 124 and extending in the same direction as the shape direction of the connecting channel, is formed to produce magnetic particles. It can be used as a particle injection channel to pass through.

A fluid containing magnetic particles may be supplied from a predetermined injection unit 300 to the particle injection channel, and accordingly, a fluid containing magnetic particles may be supplied to the reaction chamber. Additionally, the magnetic particles may be moved by the movement of the magnetic field application unit 210, and the magnetic particles may be vibrated by controlling the magnetic field of the magnetic field application unit 210. That is, magnetic particles can move from one reaction chamber to another reaction chamber by moving the magnetic field application unit 210.

Specifically, first, when the magnetic field application unit 210 is located adjacent to the first reaction chamber 111 and the magnetic particles pass through the particle injection channel, which is the fifth injection channel 125, and move to the first reaction chamber 111. , a plurality of magnetic particles may be bound by the attractive force of the magnetic field application unit 210 by the magnetic force of the magnetic field application unit 210.

In addition, the direction or intensity of the magnetic force varies with time due to the hourly variation of the current applied to the magnetic field application unit 210, and accordingly, the magnetized magnetic particles may vibrate.

After the first connection valve 161 is opened, when the magnetic field application unit 210 located adjacent to the first reaction chamber 111 moves adjacent to the second reaction chamber 112, the magnetic field application unit 210 ) Magnetic particles bound by the magnetic force can move from the first reaction chamber 111 to the second reaction chamber 112. This movement can be performed on the same principle when moving to each of the third to fourth reaction chambers 114.

The synthesis device of the present invention may further include a magnetic field moving unit 220 that moves the magnetic field applying unit 210 along the direction in which each of the plurality of reaction chambers is arranged. The magnetic field moving unit 220 includes an applying unit moving body 221 that moves the magnetic field applying unit 210 in the vertical direction; And it may be provided with a movable support body 222 formed on the upper or lower part of the approving unit movable body 221 and coupled with the housing 810 to fixedly support the approving unit movable body 221. By forming the magnetic field moving part 220, the magnetic field applying part 210 can move up and down along the z-axis direction, that is, the arrangement direction of the reaction chamber.

The authorization unit movable body 221 may be formed as a linear motor. However, the applicator movable body 221 is not limited to this, and a plurality of magnetic materials are formed on the applicator movable body 221, and the magnetic field applicator 210 changes the magnetic field at the area connected to the applicator movable body 221 to apply the magnetic field. It may be configured in other ways, such as a magnetic levitation method that moves in the longitudinal direction of the floating body 221.

The synthesis device of the present invention may further include a control unit 820 that transmits a control signal to the magnetic field application unit 210, the injection unit 300, or the temperature control unit 820. In addition, the control unit 820 can transmit control signals to all operating components, such as the magnetic field moving unit 220, the tray driving unit 620, and each valve. The synthesis device of the present invention can be operated fully automatically by the control signal of the control unit 820, and specific control matters by the control unit 820 will be described in detail in the compound synthesis method of the present invention below.

Hereinafter, a method for synthesizing a compound according to an embodiment of the present invention will be described.

In the first step, the user can input information about the reaction product into the control unit 820. Here, the control unit 820 contains information about the sample and magnetic particles stored in each injection unit 300, the type and mixing order of the sample to form the reaction product, reaction conditions (temperature, etc.), and each injection unit ( 300), information about the type of sample or magnetic particles stored may be stored.

When the user inputs information about the reaction product into the control unit 820 as described above, the control unit 820 selects the injection unit 300 to supply the sample to each reaction chamber according to the sample to be supplied to each reaction chamber. And, by analyzing the time at which the sample or magnetic particles are supplied from each injection unit 300 to each reaction chamber and the time at which the reaction product is discharged from the dispensing body 500, the magnetic field application unit 210 and the injection unit A control signal may be transmitted to (300), the temperature control unit (820), the magnetic field moving unit (220), the tray driving unit (620), or each valve.

In the first step, a control signal is transmitted to each temperature controller 710, and the temperature controller 710 operates so that the space within each reaction chamber is at a temperature suitable for the reaction, forming a reaction environment within each reaction chamber. You can do it.

In this way, by transmitting control signals from the control unit 820 to each component according to the user's input, the synthesis device of the present invention can operate fully automatically to synthesize compounds, thereby rapidly synthesizing various types of compounds. This can significantly reduce the time and cost required for compound synthesis.

In the second step, magnetic particles and the first sample are injected into the first reaction chamber among the plurality of reaction chambers, and the material in the first sample may be attached to the magnetic particles.

Here, the magnetic particles themselves are not used in the reaction, and washing to remove the material attached to the magnetic particles from the magnetic particles can be easy. Accordingly, the magnetic particles can be reused.

Specifically, in the second step, a control signal is transmitted from the control unit 820 to the injection module, and the first sample discharged from the injection unit 300 of the first injection set is discharged from the first distribution outlet and enters the first injection channel. By flowing along (121), it is supplied to the first reaction chamber (111), and the magnetic particles discharged from the injection part (300) of the fifth injection set are discharged from the fifth distribution outlet and along the fifth injection channel (125). By moving, it can be supplied to the first reaction chamber 111.

In addition, the magnetic field application unit 210 provides a magnetic field to the magnetic particles, and vibration occurs in the magnetic particles by the operation of the magnetic field application unit 210 as described above, and accordingly, the molecules of the material contained in the first sample The first molecule may be attached to the magnetic particle.

In the third step, the magnetic particles discharged from the first reaction chamber due to the movement of the magnetic field moving part 220 sequentially pass through a plurality of other reaction chambers connected to the first reaction chamber, and a reaction occurs in one of the plurality of reaction chambers. In the chamber, the material attached to the magnetic particles and the material in one sample supplied to one reaction chamber can be synthesized.

Specifically, in the third step, first, in step 3-1, the first discharge valve is opened and the first sample from which the first molecule has been removed flows into the collection channel 170 and in the first reaction chamber 111. can be removed At this time, the magnetic particles may be located in the first reaction chamber 111 by the magnetic force of the magnetic field application unit 210.

Then, the first discharge valve is closed and the first connection valve 161 is opened, and a control signal is transmitted from the control unit 820 to the applying unit moving body 221 of the magnetic field moving unit 220, thereby causing the magnetic field applying unit 210. By moving downward, magnetic particles can move from the first reaction chamber 111 to the second reaction chamber 112.

In step 3-2, a control signal is transmitted from the control unit 820 to the injection module, and the second sample discharged from the injection unit 300 of the second injection set is discharged from the second distribution outlet to the second injection channel ( It can be supplied to the second reaction chamber 112 by flowing along 122).

In addition, the magnetic field application unit 210 provides a magnetic field to the magnetic particles, and vibration occurs in the magnetic particles by the operation of the magnetic field application unit 210 as described above, and accordingly, the molecules of the material contained in the second sample A second molecule may be attached to the first molecule.

Next, the second discharge valve is opened so that the second sample from which the second molecules have been removed can flow into the collection channel 170 and be removed from the second reaction chamber 112. At this time, the magnetic particles may be located in the second reaction chamber 112 by the magnetic force of the magnetic field application unit 210.

Afterwards, the second discharge valve is closed and the second connection valve 162 is opened, and a control signal is transmitted from the control unit 820 to the applicator moving body 221 of the magnetic field moving unit 220, thereby transmitting the magnetic field applying unit 210. ) moves downward, allowing magnetic particles to move from the second reaction chamber 112 to the third reaction chamber 113.

In step 3-3, a control signal is transmitted from the control unit 820 to the injection module, and the third sample discharged from the injection unit 300 of the third injection set is discharged from the third distribution outlet to the third injection channel ( It can be supplied to the third reaction chamber 113 by flowing along 123).

In addition, the magnetic field application unit 210 provides a magnetic field to the magnetic particles, and vibration occurs in the magnetic particles by the operation of the magnetic field application unit 210 as described above, and accordingly, the molecules of the material contained in the third sample A third molecule may be attached to the second molecule.

Next, the third discharge valve is opened so that the third sample from which the third molecules have been removed can flow into the collection channel 170 and be removed from the third reaction chamber 113. At this time, the magnetic particles may be located in the third reaction chamber 113 by the magnetic force of the magnetic field application unit 210.

Afterwards, the third discharge valve is closed and the third connection valve 163 is opened, and a control signal is transmitted from the control unit 820 to the applicator moving body 221 of the magnetic field moving unit 220, thereby transmitting the magnetic field applying unit 210. ) moves downward, allowing magnetic particles to move from the third reaction chamber 113 to the fourth reaction chamber 114.

In steps 3-4, a control signal is transmitted from the control unit 820 to the injection module, and the fourth sample discharged from the injection unit 300 of the fourth injection set is discharged from the fourth distribution outlet to the fourth injection channel ( It can be supplied to the fourth reaction chamber 114 by flowing along 124).

In addition, the magnetic field application unit 210 provides a magnetic field to the magnetic particles, and vibration is generated in the magnetic particles by the operation of the magnetic field application unit 210 as described above, and accordingly, the molecules of the material included in the fourth sample are A fourth molecule may be attached to a third molecule. Accordingly, reaction products may be formed in the fourth reaction chamber 114.

Next, the fourth discharge valve is opened so that the fourth sample from which the fourth molecule has been removed can flow into the collection channel 170 and be removed from the fourth reaction chamber 114. At this time, the reaction product can be located in the fourth reaction chamber 114 by the magnetic force of the magnetic field application unit 210.

Afterwards, the fourth discharge valve is closed and the fourth connection valve is opened, and a control signal is transmitted from the control unit 820 to the applying unit moving body 221 of the magnetic field moving unit 220, causing the magnetic field applying unit 210 to move downward. By moving to , the reaction product can move from the fourth reaction chamber 114 to the delivery channel 150.

In the fourth step, the reaction product is discharged from the reaction unit 100, and the reaction product may be stored in the well of the storage tray 610. Specifically, the reaction product passing through the delivery channel 150 passes through the dispensing channel 510 of the dispensing body 500 and is discharged to the outside of the dispensing body 500, and the reaction product discharged in this way is stored in the storage tray 610. ) can be dispensed into wells. At this time, a control signal may be transmitted from the control unit 820 to the tray driving unit 620 so that the reaction product is dispensed into the empty wells of the storage tray 610.

The remaining details of the compound synthesis method according to an embodiment of the present invention are the same as those disclosed in the synthesis device according to an embodiment of the present invention described above.

Hereinafter, another embodiment of the synthesis device of the present invention will be described in detail with reference to the attached drawings.

The synthesis apparatus of the present invention includes a reaction unit 100 having at least one reaction chamber providing a reaction space; A temperature control unit 820 that controls the temperature of the reaction chamber; and an injection unit 300 that injects fluid into the reaction chamber; and a magnetic field application unit 210 that provides a magnetic field to the compound generated in the reaction chamber and moves it.

In addition, one reaction chamber and the other reaction chamber are connected to each other by a flow path, and the compound is moved by the movement of the magnetic field application unit 210, and the particles of the compound are controlled by the magnetic field of the magnetic field application unit 210. may vibrate.

Additionally, the fluid stored in one injection unit 300 among the plurality of injection units 300 may flow to one reaction chamber, and the fluid stored in the other injection unit 300 may flow to the other reaction chamber.

In the synthesis device of the present invention according to another embodiment, magnetic particles are excluded, and the remaining details of the synthesis device of the present invention according to another embodiment are disclosed in the synthesis device of the present invention according to the above-described embodiment. Same as above.

Here, in the synthesis apparatus of the present invention according to another embodiment, the compound may be magnetic, which will be described in detail below.

Hereinafter, another example of the compound synthesis method of the present invention will be described.

In the first step, the user can input information about the reaction product into the control unit 820. Here, the control unit 820 contains information about the sample and magnetic particles stored in each injection unit 300, the type and mixing order of the sample to form the reaction product, reaction conditions (temperature, etc.), and each injection unit ( 300), information about the type of sample stored may be stored.

As described above, when the user inputs information about the reaction product into the control unit 820, the control unit 820 selects the injection unit 300 to supply the sample to each reaction chamber according to the sample to be supplied to each reaction chamber. And, by analyzing the time at which the sample or magnetic particles are supplied from each injection unit 300 to each reaction chamber and the time at which the reaction product is discharged from the dispenser 500, the injection unit 300 and the temperature control unit ( 820), the control signal can be transmitted to the tray driving unit 620 or each valve.

In the first step, a control signal is transmitted to each temperature controller 710, and the temperature controller 710 operates so that the space within each reaction chamber is at a temperature suitable for the reaction, forming a reaction environment within each reaction chamber. You can do it.

In this way, by transmitting control signals from the control unit 820 to each component according to the user's input, the synthesis device of the present invention can operate fully automatically to synthesize compounds, thereby rapidly synthesizing various types of compounds. This can significantly reduce the time and cost required for compound synthesis.

In the second step, a sample is injected into the first reaction chamber among the plurality of reaction chambers, and a reaction is performed in the first reaction chamber to produce a compound.

Specifically, in the second step, a control signal is transmitted from the control unit 820 to the injection module, and the first sample discharged from the injection unit 300 of the first injection set is discharged from the first distribution outlet and enters the first injection channel. It is supplied to the first reaction chamber 111 by flowing along (121), and the fifth sample discharged from the injection part 300 of the fifth injection set is discharged from the fifth distribution outlet and flows through the fifth injection channel 125. It can be supplied to the first reaction chamber 111 by moving along.

Then, synthesis of the first sample and the fifth sample may be performed in the first reaction chamber 111 to form the first compound. At this time, the first compound is formed by combining the first molecule in the first sample and the fifth molecule in the fifth sample, and the first or fifth molecule is magnetic and the first compound is affected by the magnetic field. You can receive

Accordingly, when synthesizing the first sample and the fifth sample, the synthesis may be performed while the first molecule or the fifth molecule vibrates according to the application of a magnetic field.

In the third step, the compound discharged from the first reaction chamber sequentially passes through a plurality of other reaction chambers connected to the first reaction chamber, and the compound flows into one reaction chamber within one of the plurality of reaction chambers. Materials in the sample supplied to one reaction chamber can be synthesized.

Specifically, in the third step, first, in step 3-1, the first discharge valve is opened and the first sample from which the first molecule is removed and the fifth sample from which the fifth molecule is removed are sent to the collection channel 170. It may flow and be removed from the first reaction chamber 111. At this time, the first compound can be located in the first reaction chamber 111 by the magnetic force of the magnetic field application unit 210.

Then, the first discharge valve is closed and the first connection valve 161 is opened, and a control signal is transmitted from the control unit 820 to the applying unit moving body 221 of the magnetic field moving unit 220, thereby causing the magnetic field applying unit 210. By moving downward, the first compound can move from the first reaction chamber 111 to the second reaction chamber 112.

In step 3-2, a control signal is transmitted from the control unit 820 to the injection module, and the second sample discharged from the injection unit 300 of the second injection set is discharged from the second distribution outlet to the second injection channel ( It can be supplied to the second reaction chamber 112 by flowing along 122).

Then, the magnetic field application unit 210 provides a magnetic field to the first compound, and vibration occurs in the particles of the first compound by the operation of the magnetic field application unit 210 as described above, and accordingly, the particles contained in the second sample A second molecule, a molecule of a substance, can be attached to the first molecule to create a second compound.

Next, the second discharge valve is opened so that the second sample from which the second molecules have been removed can flow into the collection channel 170 and be removed from the second reaction chamber 112. At this time, the second compound can be located in the second reaction chamber 112 by the magnetic force of the magnetic field application unit 210.

Afterwards, the second discharge valve is closed and the second connection valve 162 is opened, and a control signal is transmitted from the control unit 820 to the applicator moving body 221 of the magnetic field moving unit 220, thereby transmitting the magnetic field applying unit 210. ) moves downward, allowing the second compound to move from the second reaction chamber 112 to the third reaction chamber 113.

In step 3-3, a control signal is transmitted from the control unit 820 to the injection module, and the third sample discharged from the injection unit 300 of the third injection set is discharged from the third distribution outlet to the third injection channel ( It can be supplied to the third reaction chamber 113 by flowing along 123).

Then, the magnetic field application unit 210 provides a magnetic field to the second compound, and vibration occurs in the particles of the second compound by the operation of the magnetic field application unit 210 as described above, and accordingly, the particles contained in the third sample A third molecule, a molecule of a substance, can be attached to a second molecule to create a third compound.

Next, the third discharge valve is opened so that the third sample from which the third molecules have been removed can flow into the collection channel 170 and be removed from the third reaction chamber 113. At this time, the third compound can be located in the third reaction chamber 113 by the magnetic force of the magnetic field application unit 210.

Afterwards, the third discharge valve is closed and the third connection valve 163 is opened, and a control signal is transmitted from the control unit 820 to the applicator moving body 221 of the magnetic field moving unit 220, thereby transmitting the magnetic field applying unit 210. ) moves downward, allowing the third compound to move from the third reaction chamber 113 to the fourth reaction chamber 114.

In steps 3-4, a control signal is transmitted from the control unit 820 to the injection module, and the fourth sample discharged from the injection unit 300 of the fourth injection set is discharged from the fourth distribution outlet to the fourth injection channel ( It can be supplied to the fourth reaction chamber 114 by flowing along 124).

In addition, the magnetic field application unit 210 provides a magnetic field to the third compound, and vibration occurs in the particles of the third compound by the operation of the magnetic field application unit 210 as described above, and accordingly, the particles contained in the fourth sample A fourth molecule, a molecule of a substance, can be attached to a third molecule. Accordingly, reaction products may be formed in the fourth reaction chamber 114.

Next, the fourth discharge valve is opened so that the fourth sample from which the fourth molecule has been removed can flow into the collection channel 170 and be removed from the fourth reaction chamber 114. At this time, the reaction product can be located in the fourth reaction chamber 114 by the magnetic force of the magnetic field application unit 210.

Afterwards, the fourth discharge valve is closed and the fourth connection valve is opened, and a control signal is transmitted from the control unit 820 to the applying unit moving body 221 of the magnetic field moving unit 220, causing the magnetic field applying unit 210 to move downward. By moving to , the reaction product can move from the fourth reaction chamber 114 to the delivery channel 150.

In the fourth step, the reaction product is discharged from the reaction unit 100, and the reaction product may be stored in the well of the storage tray 610. Specifically, the reaction product passing through the delivery channel 150 passes through the dispensing channel 510 of the dispensing body 500 and is discharged to the outside of the dispensing body 500, and the reaction product discharged in this way is stored in the storage tray 610. ) can be dispensed into wells. At this time, a control signal may be transmitted from the control unit 820 to the tray driving unit 620 so that the reaction product is dispensed into the empty wells of the storage tray 610.

The remaining details of the compound synthesis method according to an embodiment of the present invention are the same as those disclosed in the synthesis device according to an embodiment of the present invention described above.

Using the synthesis device of the present invention as described above, DNA synthesis, protein synthesis (peptide synthesis), and other chemical synthesis can be performed, and modularization and automation of key chemical processes mainly used in compound synthesis are performed. Through this, the synthesis of new drug candidate compounds can be performed quickly and at low cost.

In addition, in a situation where infectious diseases are rapidly spreading, it is easy to quickly synthesize and evaluate the effectiveness of new drug candidates with excellent drug efficacy.

The description of the present invention described above is for illustrative purposes, and those skilled in the art will understand that the present invention can be easily modified into other specific forms without changing the technical idea or essential features of the present invention. will be. Therefore, the embodiments described above should be understood in all respects as illustrative and not restrictive. For example, each component described as unitary may be implemented in a distributed manner, and similarly, components described as distributed may also be implemented in a combined form.

The scope of the present invention is indicated by the patent claims described below, and all changes or modified forms derived from the meaning and scope of the claims and their equivalent concepts should be construed as being included in the scope of the present invention.

100: reaction unit 101: reaction body
111: first reaction chamber 112: second reaction chamber
113: third reaction chamber 114: fourth reaction chamber
121: first injection channel 122: second injection channel
123: Third injection channel 124: Fourth injection channel
125: 5th injection channel 131: 1st connection channel
132: second connection channel 133: third connection channel
141: first discharge channel 142: second discharge channel
143: Third discharge channel 144: Fourth discharge channel
150: Transmission channel 160a: Left actuator
160b: Right operating body 161: First connection valve
162: second connection valve 163: third connection valve
164: Delivery valve 170: Collection channel
210: Magnetic field presence part 220: Magnetic field eastern part
221: Authorization moving body 222: Moving site support body
300: injection unit 310: injector
311: Actuator 312: Pressure body
313: pusher 320: storage tank
330: Injection support frame 400: Distribution unit
410: Fluid control body 411: Support plate
412: fluid pipe 420: selective distributor
421: Distribution pipe 422: Connector pipe
423: delivery tube 500: dispenser
510: Dispensing channel 610: Storage tray
620: Tray eastern part 621: Front and rear drive body
622: Left and right driving bodies 623: Drive case
710: Temperature controller 720: Regulator support body
810: Housing 820: Control unit

Claims (17)

A reaction unit including at least one reaction chamber providing a reaction space;
a temperature control unit that controls the temperature of the reaction chamber;
an injection unit that injects fluid into the reaction chamber; and
It includes a magnetic field application unit that provides a magnetic field to magnetic particles contained in the fluid and performs movement,
One reaction chamber and the other reaction chamber are connected to each other by a flow path,
The magnetic particles are moved by the movement of the magnetic field application part,
A fully automatic compound synthesis device, wherein the magnetic particles are vibrated by controlling the magnetic field of the magnetic field application unit.
In claim 1,
A fully automatic compound synthesis device, characterized in that the fluid stored in one of the plurality of injection portions flows to the one reaction chamber, and the fluid stored in the other injection portion flows to the other reaction chamber.
In claim 1,
The reaction unit,
a reaction body with the reaction chamber formed therein; and
A fully automatic compound synthesis device characterized by further comprising a connection channel that connects one reaction chamber to another reaction chamber.
In claim 3,
The reaction unit,
an injection channel formed in the reaction body and providing a flow path for fluid flowing from the injection unit to the reaction chamber;
a collecting channel formed in the reaction body and collecting liquid discharged after reaction in the reaction chamber; and
A fully automatic compound synthesis device further comprising a discharge channel formed in the reaction body and providing a flow path for fluid flowing from the reaction chamber to the collecting channel.
In claim 3,
The reaction unit is a fully automatic compound synthesis device, characterized in that it further includes a dispenser that combines with the reaction body and dispenses the reaction product discharged from the reaction body to the outside.
In claim 1,
A fully automatic compound synthesis device, wherein one part is coupled to the injection unit and the other part is coupled to the reaction unit, and further includes a distribution unit that transfers fluid from the injection unit to the reaction unit.
In claim 6,
The distribution unit,
a distribution channel connected to the injection unit and providing a flow path for fluid; and
A fully automatic compound synthesis device comprising a distribution outlet for discharging the fluid that has passed through the distribution channel.
In claim 6,
The distribution unit,
A fluid control body that has a fluid pipe formed in the shape of a pipe and a support plate for supporting the fluid pipe and performs three-dimensional movement; and
A fully automatic compound synthesis device comprising a selective distributor that performs three-dimensional movement and rotation to selectively connect to the fluid pipe and receives the fluid passing through the fluid pipe.
In claim 1,
A fully automatic compound synthesis apparatus further comprising a storage tray having a plurality of wells, which are spaces for storing reaction products discharged from the reaction unit.
In claim 9,
A fully automatic compound synthesis device characterized by further comprising a tray drive unit that engages with the storage tray and moves the storage tray.
In claim 1,
The injection part,
a reservoir that stores fluid and supplies the fluid to the reaction unit; and
A fully automatic compound synthesis device comprising an injector coupled to the reservoir and providing pressure to the fluid in the reservoir.
In claim 1,
The temperature control unit,
a temperature controller that heats or cools the reaction chamber; and
A fully automatic compound synthesis device comprising a regulator support body coupled to the temperature controller and supporting the temperature controller.
In claim 1,
A fully automatic compound synthesis device further comprising a magnetic field moving unit that moves the magnetic field applying unit moving along the direction in which each of the plurality of reaction chambers is arranged.
In claim 1,
A fully automatic compound synthesis device further comprising a control unit that transmits a control signal to the magnetic field application unit, the injection unit, or the temperature control unit.
In the compound synthesis method using the fully automatic compound synthesis device of claim 14,
A first step in which the user inputs information about the reaction product into the control unit;
A second step in which the magnetic particles and the first sample are injected into a first reaction chamber among a plurality of reaction chambers, and the material in the first sample is attached to the magnetic particles;
As the magnetic particles discharged from the first reaction chamber due to the movement of the magnetic field application unit sequentially pass through a plurality of other reaction chambers connected to the first reaction chamber, the magnetic particles are stored in one of the plurality of reaction chambers. A third step in which the material attached to and the material in one sample supplied to the one reaction chamber are synthesized; and
A method for synthesizing a compound comprising a fourth step in which the reaction product is discharged from the reaction unit and the reaction product is stored in a well of a storage tray.
A reaction unit including at least one reaction chamber providing a reaction space;
a temperature control unit that controls the temperature of the reaction chamber;
an injection unit that injects fluid into the reaction chamber; and
It includes a magnetic field application unit that provides a magnetic field to the compound generated in the reaction chamber and performs movement,
One reaction chamber and the other reaction chamber are connected to each other by a flow path,
The compound is moved by the movement of the magnetic field applied portion,
The particles of the compound are vibrated by controlling the magnetic field of the magnetic field application unit,
A fully automatic compound synthesis device, wherein the fluid stored in one of the plurality of injection portions flows into the one reaction chamber, and the fluid stored in the other injection portion flows into the other reaction chamber.
In the compound synthesis method using the fully automatic compound synthesis device of claim 16,
A first step in which the user inputs information about the reaction product into the control unit;
A second step in which a sample is injected into a first reaction chamber among a plurality of reaction chambers and a reaction is performed in the first reaction chamber to produce a compound;
The compound discharged from the first reaction chamber sequentially passes through a plurality of other reaction chambers connected to the first reaction chamber, and the compound flows into the one reaction chamber within one of the plurality of reaction chambers. A third step in which materials in the sample supplied to the one reaction chamber are synthesized; and
A method for synthesizing a compound comprising a fourth step in which the reaction product is discharged from the reaction unit and the reaction product is stored in a well of a storage tray.