KR20230131177A - 항바이러스 화합물로서 중수소화된 아미노티아졸 화합물 - Google Patents

항바이러스 화합물로서 중수소화된 아미노티아졸 화합물 Download PDF

Info

Publication number
KR20230131177A
KR20230131177A KR1020237017885A KR20237017885A KR20230131177A KR 20230131177 A KR20230131177 A KR 20230131177A KR 1020237017885 A KR1020237017885 A KR 1020237017885A KR 20237017885 A KR20237017885 A KR 20237017885A KR 20230131177 A KR20230131177 A KR 20230131177A
Authority
KR
South Korea
Prior art keywords
alkyl
deuterium
herpes
compounds
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237017885A
Other languages
English (en)
Korean (ko)
Inventor
크리스티안 게게
제럴드 클레이만
Original Assignee
이노베이티브 몰리큘스 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이노베이티브 몰리큘스 게엠베하 filed Critical 이노베이티브 몰리큘스 게엠베하
Publication of KR20230131177A publication Critical patent/KR20230131177A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020237017885A 2020-10-29 2021-10-28 항바이러스 화합물로서 중수소화된 아미노티아졸 화합물 Pending KR20230131177A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20204545.6 2020-10-29
EP20204545 2020-10-29
PCT/EP2021/080023 WO2022090409A1 (en) 2020-10-29 2021-10-28 Deuterated aminothiazole compounds as antiviral compounds

Publications (1)

Publication Number Publication Date
KR20230131177A true KR20230131177A (ko) 2023-09-12

Family

ID=73037895

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237017885A Pending KR20230131177A (ko) 2020-10-29 2021-10-28 항바이러스 화합물로서 중수소화된 아미노티아졸 화합물

Country Status (9)

Country Link
US (1) US12552756B2 (https=)
EP (1) EP4237414A1 (https=)
JP (1) JP2023552274A (https=)
KR (1) KR20230131177A (https=)
CN (1) CN116783171A (https=)
AU (1) AU2021367976A1 (https=)
CA (1) CA3196645A1 (https=)
MX (1) MX2023004955A (https=)
WO (1) WO2022090409A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4466255A1 (en) 2022-01-17 2024-11-27 Innovative Molecules GmbH Solid crystalline forms of helicase-primase inhibitors and process of preparation thereof
IL325911A (en) 2023-07-17 2026-03-01 Innovative Molecules Gmbh Micronized crystalline hydrochloride salts of antiviral helicase-primase inhibitor compounds
WO2026078039A1 (en) 2024-10-09 2026-04-16 Innovative Molecules Gmbh Oral administration forms of antiviral helicase-primase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP2000000109A (es) * 1999-12-23 2002-08-30 Gerald Kleymann Derivados de tiazolilamida
GEP20207128B (en) * 2016-04-06 2020-07-10 Molecules Gm Innovative Aminothiazole derivatives useful as antiviral agents
MX2020003369A (es) * 2017-10-05 2020-07-29 Innovative Molecules Gmbh Enantiomeros de tiazoles sustituidos como compuestos antivirales.
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑

Also Published As

Publication number Publication date
CN116783171A (zh) 2023-09-19
AU2021367976A9 (en) 2025-03-13
EP4237414A1 (en) 2023-09-06
US20230391738A1 (en) 2023-12-07
MX2023004955A (es) 2023-05-17
WO2022090409A1 (en) 2022-05-05
US12552756B2 (en) 2026-02-17
AU2021367976A1 (en) 2023-06-08
JP2023552274A (ja) 2023-12-15
CA3196645A1 (en) 2022-05-05

Similar Documents

Publication Publication Date Title
US12527778B2 (en) Enantiomers of a series of antiviral compounds
EP3209656B1 (en) Indole carboxamides compounds useful as kinase inhibitors
US12552756B2 (en) Deuterated aminothiazole compounds as antiviral compounds
JP2025502300A (ja) ヘリカーゼプリマーゼ阻害剤の固体結晶形態及びその製造方法
CN110483487B (zh) 一种2-硫甲基吡唑嘧啶酮类化合物、其制备方法、药物组合物及应用
TW202045516A (zh) 雙環磺醯胺
US20160368944A1 (en) Linked purine pterin hppk inhibitors useful as antibacterial agents
WO2022262784A1 (zh) Idh突变体抑制剂及其用途
CN116531373B (zh) 噻唑类化合物、其药物组合物及应用
EP4422747A1 (en) Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
JP2024540216A (ja) プロテインキナーゼ、特には、ｄｙｒｋ１ａ、ｃｌｋ１及び／又はｃｌｋ４、の阻害剤としてのイミダゾロン誘導体
CN118556045A (zh) 解旋酶-引发酶抑制剂的固体结晶形式及其制备方法
KR100290533B1 (ko) 항바이러스 활성을 가지는 2-아미노퓨린
EP4422753A1 (en) Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
CN113015736A (zh) 用于诱导软骨发生以治疗关节损害的6-羟基-8-氧杂三环[3.2.1.02,4]辛烷-2-甲酰胺衍生物
BR112020006710B1 (pt) Enantiômeros de tiazóis substituídos como compostos antivirais
HK1235064B (en) Indole carboxamides compounds useful as kinase inhibitors
HK1235064A1 (en) Indole carboxamides compounds useful as kinase inhibitors

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R18 Changes to party contact information recorded

Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R18-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000