KR20230096938A - An Organic and Inorganic Convergent Type of a Hybrid Complex Composition for Shielding a Harmful Light - Google Patents

Abstract

The present invention relates to a hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light. A composition for blocking ultraviolet rays includes at least one inorganic oxide selected from zinc oxide and titanium dioxide; and an organic compound having a phenolic group fused to an inorganic oxide.

Description

An Organic and Inorganic Convergent Type of a Hybrid Complex Composition for Shielding a Harmful Light}

The present invention relates to an organic-inorganic fusion hybrid composite composition for blocking harmful light, and more specifically, to an organic-inorganic hybrid composite composition for blocking harmful light that effectively blocks ultraviolet rays by using an inorganic compound coated with an organic compound. .

Natural light includes various wavelength bands, and includes light such as a wavelength band in the visible ray region, UV-A with a wavelength of 320 to 400 nm, UV-B with a wavelength of 290 to 320 nm, and UV-C with a wavelength of 100 to 290 nm. . Among these ultraviolet rays, UV-A and UV-B having relatively large wavelengths may reach the earth's surface and affect humans. For example, such ultraviolet rays can cause wrinkles by making the skin red, discolored, or damaging collagen. In addition, if exposed to a large amount of ultraviolet light, ultraviolet light can cause burns or skin cancer. Therefore, it is necessary to block ultraviolet rays so that the skin is not exposed to such ultraviolet rays, and an invention for a cosmetic composition for blocking ultraviolet rays is known in this field. Patent Publication No. 10-2012-0039205 discloses an oil-in-water solidifying cosmetic composition for sunscreen including a sodium alkyl group as a solidifying agent. In addition, Patent Publication No. 10-2013-0066773 discloses an ultraviolet cosmetic composition containing ethyl ferurate as an active ingredient. The prior art or known technology is composed of an organic compound, and has a function of preventing inflammation or tissue damage or skin damage of skin tissue due to ultraviolet damage, but has a weak blocking function to block ultraviolet rays from reaching the skin. have In addition, it has a disadvantage that side effects may occur due to the use of sunscreen. Therefore, it is necessary to create a cosmetic composition capable of solving these problems.

The present invention is to solve the problems of the prior art and has the following object.

Prior Art 1: Patent Publication No. 10-2012-0039205 (Amorepacific Co., Ltd., published on April 25, 2012) Oil-in-water solidifying cosmetic composition for sunscreen Prior Art 2: Patent Publication No. 10-2013-0066773 (Korea Cola -> Korea Kolmar Co., Ltd., published on June 21, 2013) Cosmetic composition for sunscreen containing ethyl pherolate

An object of the present invention is to provide an organic-inorganic fusion type hybrid composite composition for blocking harmful light that effectively blocks ultraviolet rays while improving stability by a hybrid form in which an organic compound having a phenolic group and an inorganic compound having a UV blocking function are fused. will be.

According to a preferred embodiment of the present invention, a composition for blocking ultraviolet rays includes at least one inorganic oxide selected from zinc oxide and titanium dioxide; and an organic compound having a phenolic group fused to an inorganic oxide.

According to another preferred embodiment of the present invention, the phenolic groups include phenolic acids and aromatic amino acids.

According to another preferred embodiment of the present invention, the inorganic oxide is in the form of a powder coated with an organic compound.

According to another preferred embodiment of the present invention, the composition according to the present invention becomes a cosmetic in the form of a lotion, emulsion, cream, stick, balm, spray or mist.

The organic-inorganic fusion hybrid composite composition for blocking harmful light according to the present invention is fused with an organic compound and an inorganic material to improve stability and increase the UV blocking effect. The composite composition according to the present invention has an excellent feeling of use and can be used as various types of cosmetics, and has various types of beneficial effects on the human body, including UV protection, without causing side effects. The complex composition according to the present invention may be made into various formulations such as lotion, emulsion, cream, stick, balm, spray, mist or the like, and the present invention is not limited thereby.

1 illustrates an embodiment of a manufacturing process of a hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light according to the present invention.
Figure 2 shows the results of the UV absorbing ability test by the composition according to the present invention.
Figure 3 shows the test results of the sunscreen effect of the composition according to the present invention.
Figure 4 shows the safety test results of the composition according to the present invention.
Figure 5 shows the result of the cloudiness phenomenon that appears when the composition according to the present invention is applied to the skin.

Below, the present invention will be described in detail with reference to the embodiments presented in the accompanying drawings, but the embodiments are for a clear understanding of the present invention, and the present invention is not limited thereto. In the following description, components having the same reference numerals in different drawings have similar functions, so repeated descriptions are not made unless necessary for understanding the invention, and well-known components are briefly described or omitted, but the present invention It should not be understood as being excluded from the embodiment of.

The organic-inorganic fusion type hybrid composite composition for blocking harmful light according to the present invention includes an inorganic oxide; and organic compounds having a phenolic acid fused to an inorganic compound. The inorganic oxide may include, for example, zinc oxide or titanium oxide. In addition, the organic compound having a phenol group includes, for example, an aromatic acid having a functional group such as an aromatic ring or an organic acid, and specifically includes phenolic acid and aromatic amino acid. (aromatic amino acid). In addition, phenolic acid includes hydroxycinnamic acid, caffeic acid, cichoric acid, cinnamic acid, chlorogenic acid, and diferulic acid. diferulic acid, coumaric acid, ferulic acid, sinapinic acid, caftraric acid, coutaric acid and fertaric acid ) and at least one component selected from the group consisting of or a derivative thereof. Derivatives thereof also include, for example, hydroxy derivatives of cinnamic acid. Fusion includes a form in which an inorganic compound and an organic compound are combined, for example, an organic compound is coated on the surface of an inorganic oxide in powder form, blended, or a form in which a group of an organic compound is bonded to an inorganic compound. , or the organic compound may be dissolved in a solvent while surrounding the inorganic compound. By this fusion, inorganic compounds in powder form can be physically or chemically separated from each other, thereby uniformly distributing the inorganic compounds throughout the composition. A process for preparing such a composition will be described below. .

1 illustrates an embodiment of a manufacturing process of a hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light according to the present invention.

Referring to FIG. 1 , the preparation process of the hybrid composite composition includes preparing an inorganic compound (P11); Grinding or milling the inorganic compound to adjust the particle size to make nanoparticles (P12); Treating the surface of the nano-inorganic compound (P14); Preparing an organic compound (P14) and fusing it with a nano-inorganic compound (P15); and adjusting the pH of the fusion modulator (P16).

The inorganic compound may be, for example, zinc oxide, titanium dioxide, or a mixture thereof, and may be prepared in a powder form (P11). When zinc oxide or titanium dioxide transmits light in the visible ray wavelength band, it disperses UV-A ultraviolet light having a wavelength of 320 to 400 nm or UV-B ultraviolet light having a wavelength of 280 to 320 nm, and such ultraviolet rays penetrate the skin. It needs to have properties that block it from reaching it. Since the transmission of visible light and blocking of ultraviolet rays are greatly affected by the particle size of the inorganic compound, the particle size of the inorganic compound needs to be controlled. The inorganic compound may be made of, for example, nanoparticles having a diameter of 100 nm corresponding to 1/4 of the maximum wavelength of ultraviolet light, and the average diameter of the nano-inorganic compound is 100 nm or less and has a diameter of 30 to 50 nm The particle size can be adjusted so that the nano-inorganic compound is 80% or more (P12). Inorganic compounds can be made into nano-inorganic compounds by various milling devices or homogenizers, and surface treatment can be selectively performed on the nano-inorganic compounds thus formed (P13). The surface treatment has a function of facilitating bonding with phenol groups while improving the dispersibility of nano-inorganic compounds. Surface treatment may be carried out in such a way that the surface is modified by, for example, a silane coupling agent. For example, a nano-inorganic compound for surface treatment may be added to a methyl ethyl ketone solvent and stirred at a temperature of 15 to 25 ° C. for 1 to 10 hours, and ultrasonic treatment may be performed for 5 to 60 minutes during the stirring process. . In this way, the surface-treated nano-inorganic compound is dried to make a nano-inorganic compound powder.

An organic compound having a phenol group may be prepared (P14), and the organic compound having a phenol group includes, for example, an aromatic acid having a functional group such as an aromatic ring or an organic acid, , specifically phenolic acid and aromatic amino acid. In addition, phenolic acids include hydroxycinnamic acid, caffeic acid, cichoric acid, cinnamic acid, chlorogenic acid, and diferulic acid. diferulic acid, coumaric acid, ferulic acid, sinapinic acid, caftraric acid, coutaric acid and fertaric acid ) may include at least one component selected from the group consisting of or a derivative thereof. Derivatives thereof may also include, for example, hydroxy derivatives of cinnamic acid. In addition, nano-inorganic compounds may be added to such organic compounds to be fused (P15). The organic compound and inorganic compound to be fused may be, for example, 1 to 2,000 wt% of the inorganic compound based on 100 wt% of the organic compound. The organic compound may be prepared in the form of a solution, and, for example, a solvent may be prepared by adding a compound containing a predetermined amount of phenolic acid to ethylene glycol, propylene glycol, an alcohol solvent, or a solvent similar thereto. In order to improve dispersibility in such a solution, for example, methyl methacrylate (MMA), organomolygosiloxane, organopolysiloxane, or a silicone-based surfactant may be added. Thereafter, a nano-inorganic compound powder may be added in a predetermined amount to the dispersion solvent thus formed to form a composition in the form of a solution (P15). The composition prepared in this way can be used as a material for cosmetics made in the form of lotion, emulsion, cream, stick, balm, spray or mist, for example. The UV blocking effect of zinc oxide or titanium dioxide varies depending on the pH, and for example, the pH may be adjusted to 4.0 to 7.5 by adding an appropriate pH adjusting agent to the composition (P16). pH adjustment can be made at various stages and is not limited to the examples presented.

Hereinafter, an embodiment in which the composition according to the present invention is prepared according to such a manufacturing process will be described.

embodiment

Example 1

Zinc oxide (ZnO) was milled in a homogenizer to make nanoparticle powder with an average diameter of 35 to 40 nm, which was then added to ethylene glycol together with hydroxycinnamic acid extracted from fruits to fuse them. 3 wt% of zinc oxide and 1 wt% of hydroxycinnamic acid were added to 300 ml of ethylene glycol, and 0.1 wt% of organopolysiloxane was added and stirred at a temperature of 20 ° C. at a speed of 150 rmp for 5 hours. , while adjusting the pH to be 6.5, a composition in a transparent form was prepared.

Example 2

A composition was prepared in the same manner as in Example 1, except that the same amount of titanium dioxide was used.

Example 3

A composition was prepared in the same manner as in Example 1, except that the same amounts of zinc oxide and titanium dioxide were used.

Example 4

A composition was prepared in the same manner as in Example 1, except that zinc oxide surface-modified by a silane coupling agent was used.

Efficacy test

Efficacy tests were conducted on the compositions prepared according to Examples 1 to 4. Efficacy tests were conducted on visible light transmittance, UV absorbance measurement, UV blocking effect, formulation stability evaluation, and whitening improvement effect.

Visible light transmittances in the 550 nm wavelength band of the compositions according to Examples 1 to 4 were respectively as follows.

embodiment One 2 3 4 Transmittance (550 nm) 76.2 78.5 77.8 89.5

The composition according to Example 4 exhibited the highest visible light transmittance, which seems to be due to the excellent dispersibility of the composition according to Example 4. In the case of Examples 1 to 3, the transmittance of visible light was found to be 75% or more. The ultraviolet ray absorption ability of the UV-A and 　UV-B wavelength bands of the composition according to Example 1 was measured by a UV-VIS photospectrophotometer. ), and the measurement results are presented in FIG. 2. The left side of FIG. 2 shows the result of measuring the UV absorbance of a known organic sunscreen, and the right side of FIG. 2 shows the result of measuring the UV absorbance of the composition according to Example 1. It can be seen that the composition according to the present invention has excellent absorbance with respect to the entire UV-A and UV-B wavelength range.

A UV-B sensitive yeast bio assay for testing the sunscreen effect was conducted, and the results are presented in FIG. 3 . The test was conducted by in vitro bio-assay method, and after smearing the yeast strain on the medium for the test, dividing the area on the lid of the petri dish, the sample in which 0.2 wt% of the organic-inorganic simple mixture was added to the basic sunscreen base and in Example 2 A certain amount of 0.2 wt% of the organic-inorganic fusion composite powder according to the method was applied. The basic sunscreen base does not contain sunscreen, and the known sunscreen is independently applied in the same amount, and each area is irradiated with UV-B ultraviolet rays for 120 to 300 seconds, and incubated in a 35 ℃ incubator for two days to grow bacteria level was confirmed. As shown in FIG. 3 , the growth of bacteria was confirmed in the area where the known sunscreen and the composition according to Example 2 were applied, and it was confirmed that the bacteria did not grow in the area where the sunscreen base was applied. In addition, it was confirmed that the growth density of bacteria in the application area according to the embodiment was high.

SPF (Sun protection Factor) for the test for UV protection was measured, and after attaching 55.5 cm 2 of the Transpore Tape to the sample holder for measurement, 2 mg/cm 2 of the composition according to the example was taken and placed on the Transpore Tape. Apply evenly to the non-adhesive surface. After 15 minutes of application, the SPF level was measured using the SPF-290 Analyzer, and the measurement results are presented in Table 2, and comparative examples show the test results of known sunscreens.

embodiment One 2 3 4 comparison example SPF 45 43 46 48 21

The stability of the composition was tested, and precipitation and browning were tested for the stability test, and the test results are presented in FIG. 4 . 1 wt% of the composition according to Example 1 and 1 wt% of a known sunscreen were added to an alcohol solvent and left at a temperature of 25 ° C. for 48 hours, and the left and right sides of FIG. It shows the test results of sunscreen. As can be seen from Figure 4, it was confirmed that bottom precipitation did not occur and browning did not occur in the case of the composition according to the present invention. Sunscreens correspond to functional cosmetics used for the purpose of skin safety, but the cosmetic aspect also needs to be considered. In the case of a known inorganic sunscreen, when applied to the skin, a white cast phenomenon and stickiness may occur due to the ingredients of the inorganic sunscreen material. The composition according to Example 1 and a known inorganic sunscreen were applied to the skin, and test results exposed to outdoor ultraviolet rays at a temperature of 25° C. are presented in FIG. 5 . The left part corresponds to the part to which the composition according to the present invention is applied, and the right part corresponds to the part to which the known inorganic sunscreen is applied. As can be seen from FIG. 5, in the case of the composition according to the present invention, it can be seen that cloudiness and stickiness are significantly reduced. Although the present invention has been described in detail with reference to the examples presented above, it is common knowledge in this field. Those who have will be able to make various modifications and variations of the invention without departing from the technical spirit of the present invention with reference to the presented embodiments. The present invention is not limited by these variations and modifications, but is limited only by the claims appended below.

P11: Inorganic compound preparation P12: Grinding/particle size adjustment
P13: Surface treatment P14: Organic compound
P15: fusion P16: pH adjustment

Claims (2)

In the composition for blocking ultraviolet rays,
at least one inorganic oxide selected from zinc oxide and titanium dioxide; and
It includes an organic compound having a phenolic group fused to an inorganic oxide,
Phenolic groups include phenolic acids and aromatic amino acids;
The inorganic oxide is a hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light, characterized in that the surface is modified by a silane coupling agent and then becomes a powder form coated with an organic compound. Cosmetics in the form of a lotion, emulsion, cream, stick, balm, spray or mist comprising the composition of claim 1.

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