KR102633795B1 - An Organic and Inorganic Convergent Type of a Hybrid Complex Composition for Shielding a Harmful Light - Google Patents

Abstract

The present invention relates to a hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light. The composition for blocking ultraviolet rays includes at least one inorganic oxide selected from zinc oxide and titanium dioxide; and organic compounds having a phenolic group fused to an inorganic oxide.

Description

{An Organic and Inorganic Convergent Type of a Hybrid Complex Composition for Shielding a Harmful Light}

The present invention relates to a hybrid composite composition in the form of an organic-inorganic fusion for blocking harmful light, and specifically relates to a hybrid composite composition in the form of an organic-inorganic fusion for blocking harmful light that effectively blocks ultraviolet rays by an inorganic compound coated with an organic compound. .

Natural light includes various wavelength bands, including light in the visible region, UV-A with a wavelength of 320 to 400 nm, UV-B with a wavelength of 290 to 320 nm, and UV-C with a wavelength of 100 to 290 nm. . Among these ultraviolet rays, UV-A and UV-B, which have relatively large wavelengths, can reach the earth's surface and affect humans. For example, these ultraviolet rays can cause skin to turn red, become pigmented, or damage collagen, causing wrinkles to form. Additionally, if exposed to large amounts of UV rays, UV rays can cause burns or skin cancer. Therefore, it is necessary to block ultraviolet rays so that the skin is not exposed to such ultraviolet rays, and inventions regarding cosmetic compositions for blocking ultraviolet rays are known in the field. Patent Publication No. 10-2012-0039205 discloses a cosmetic composition for sunscreen in an oil-in-water solidified formulation containing a sodium alkyl group as a solidifying agent. Additionally, Patent Publication No. 10-2013-0066773 discloses an ultraviolet cosmetic composition containing ethyl feryl rate as an active ingredient. Prior art or known technology is made of organic compounds and has the function of preventing inflammation or tissue damage or skin damage caused by ultraviolet rays, but the disadvantage is that the blocking function to block ultraviolet rays from reaching the skin is weak. has It also has the disadvantage of possibly causing side effects due to the use of sunscreen. Therefore, there is a need to create a cosmetic composition that can solve these problems.

The present invention is intended to solve the problems of the prior art and has the following purposes.

Prior Art 1: Patent Publication No. 10-2012-0039205 (Amore Pacific Co., Ltd., published on April 25, 2012) Oil-in-water solidified cosmetic composition for UV protection Prior Art 2: Patent Publication No. 10-2013-0066773 (Cola Korea -> Kolmar Korea Co., Ltd., published on June 21, 2013) Cosmetic composition for sunscreen containing ethyl ferrolate

The object of the present invention is to provide a hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light, which improves stability and effectively blocks ultraviolet rays by combining an organic compound with a phenol group and an inorganic compound with a UV-blocking function in a hybrid form. will be.

According to a preferred embodiment of the present invention, a composition for blocking ultraviolet rays includes at least one inorganic oxide selected from zinc oxide and titanium dioxide; and organic compounds having a phenolic group fused to an inorganic oxide.

According to another suitable embodiment of the invention, the phenol group includes phenolic acid and aromatic amino acid.

According to another suitable embodiment of the present invention, the inorganic oxide is in the form of a powder coated with an organic compound.

According to another suitable embodiment of the present invention, the composition according to the present invention is a cosmetic in the form of lotion, emulsion, cream, stick, balm, spray or mist.

The hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light according to the present invention combines organic compounds and inorganic materials to improve stability and increase ultraviolet ray blocking effect. The composite composition according to the present invention has an excellent feeling of use, so it can be used in various types of cosmetics, and produces various beneficial effects on the human body, including UV protection, without causing side effects. The composite composition according to the present invention can be made into various formulations such as lotion, emulsion, cream, stick, balm, spray, mist or similar, and the present invention is not limited thereby.

Figure 1 shows an example of the manufacturing process of a hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light according to the present invention.
Figure 2 shows the results of an ultraviolet absorption ability test by the composition according to the present invention.
Figure 3 shows the test results of the ultraviolet ray blocking effect of the composition according to the present invention.
Figure 4 shows the safety test results of the composition according to the present invention.
Figure 5 shows the results of the white clouding phenomenon that appears when the composition according to the present invention is applied to the skin.

Below, the present invention will be described in detail with reference to the embodiments shown in the attached drawings, but the examples are for a clear understanding of the present invention and the present invention is not limited thereto. In the description below, components having the same reference numerals in different drawings have similar functions, so unless necessary for understanding the invention, the description will not be repeated, and well-known components will be briefly described or omitted, but the present invention It should not be understood as being excluded from the embodiments.

The hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light according to the present invention includes an inorganic oxide; and organic compounds having a phenol group (phenolic acid) fused to an inorganic compound. Inorganic oxides may include, for example, zinc oxide or titanium dioxide. Additionally, organic compounds having a phenol group include, for example, aromatic acids having functional groups such as aromatic rings or organic acids, specifically phenolic acids and aromatic amino acids. (aromatic amino acid) included. Additionally, phenolic acids include hydroxycinnamic acid, caffeic acid, cichoric acid, cinnamic acid, chlorogenic acid, and diperulic acid. diferulic acid, coumaric acid, ferulic acid, sinapinic acid, caftraric acid, coutaric acid and fertaric acid ) and at least one component selected from the group consisting of or derivatives thereof. Also their derivatives include, for example, the hydroxy derivatives of cinnamic acid. Fusion includes a form in which an inorganic compound and an organic compound are combined, for example, an organic compound is coated on the surface of an inorganic oxide in powder form, blended, or a group of an organic compound is bonded to an inorganic compound. Alternatively, the organic compound may dissolve in the solvent and surround the inorganic compound. Through such fusion, inorganic compounds in powder form can be physically or chemically separated from each other, and thereby the inorganic compounds can be uniformly distributed throughout the composition. The process of producing such a composition is explained below. .

Figure 1 shows an example of the manufacturing process of a hybrid composite composition in the form of organic-inorganic fusion for blocking harmful light according to the present invention.

Referring to Figure 1, the manufacturing process of the hybrid composite composition includes preparing an inorganic compound (P11); A step of crushing or milling the inorganic compound to adjust the particle size to make nanoparticles (P12); Processing the surface of the nano-inorganic compound (P14); Preparing an organic compound (P14) and fusing it with a nano-inorganic compound (P15); and adjusting the pH of the fusion agent (P16).

The inorganic compound may be, for example, zinc oxide, titanium dioxide, or a mixture thereof, and may be prepared in powder form (P11). When zinc oxide or titanium dioxide transmits light in the visible wavelength range, it disperses UV-A ultraviolet light with a wavelength of 320 to 400 ㎚ or UV-B ultraviolet light with a wavelength of 280 to 320 ㎚, so that such ultraviolet rays do not penetrate the skin. It needs to have properties that block it from reaching it. Since the visible light transmission and ultraviolet ray blocking properties are greatly affected by the particle size of the inorganic compound, the particle size of the inorganic compound needs to be adjusted. For example, the inorganic compound can be made of nanoparticles with a diameter of 100 nm, which corresponds to 1/4 of the maximum wavelength of ultraviolet rays, and the average diameter of the nano-inorganic compound is 100 nm or less and has a diameter of 30 to 50 nm. The particle size can be adjusted so that the nano inorganic compound is more than 80% (P12). Inorganic compounds can be made into nano-inorganic compounds using various milling devices or homogenizers, and the nano-inorganic compounds thus made can be selectively surface treated (P13). Surface treatment has the function of improving the dispersibility of nano-inorganic compounds and facilitating their bonding with phenol groups. Surface treatment may be carried out by, for example, surface modification using a silane coupling agent. For example, nano inorganic compounds for surface treatment can be added to a methyl ethyl ketone solvent and stirred at a temperature of 15 to 25 ° C for 1 to 10 hours, and ultrasonicated for 5 to 60 minutes during the stirring process. . Nano-inorganic compounds surface-treated in this way can be dried and made into nano-inorganic compound powder.

An organic compound having a phenol group can be prepared (P14), and the organic compound having a phenol group includes, for example, an aromatic acid having a functional group such as an aromatic ring or an organic acid. , specifically includes phenolic acid and aromatic amino acid. Additionally, phenolic acids include hydroxycinnamic acid, caffeic acid, cichoric acid, cinnamic acid, chlorogenic acid, and diperulic acid. diferulic acid, coumaric acid, ferulic acid, sinapinic acid, caftraric acid, coutaric acid and fertaric acid ) may include at least one component selected from the group consisting of or derivatives thereof. Derivatives of these may also include, for example, hydroxy derivatives of cinnamic acid. And nano-inorganic compounds can be added to such organic compounds to fuse them (P15). As for the organic and inorganic compounds to be fused, for example, 1 to 2,000 wt% of the inorganic compound may be added to 100 wt% of the organic compound. Organic compounds can be prepared in solution form, for example, a solvent can be created by adding a predetermined amount of a compound containing phenolic acid into ethylene glycol, propylene glycol, alcohol solvent, or similar solvent. To improve dispersibility in such a solution, for example, methyl methacrylate (MMA), organomolygo siloxane, organopolysiloxane, or silicone-based surfactant may be added. Thereafter, a predetermined amount of nano-inorganic compound powder can be added to the formed dispersion solvent to create a composition in the form of a solution (P15). The composition prepared in this way can be used as a material for cosmetics made in the form of, for example, lotion, emulsion, cream, stick, balm, spray or mist. The UV blocking effect of zinc oxide or titanium dioxide varies depending on pH, and for example, the pH can be adjusted to 4.0 to 7.5 by adding an appropriate pH adjuster to the composition (P16). pH adjustment can be accomplished at various stages and is not limited to the presented examples.

Below, an example in which the composition according to the present invention is manufactured according to this manufacturing process will be described.

Example

Example 1

Zinc oxide (ZnO) was milled in a homogenizer to make nanoparticle powder with an average diameter of 35 to 40 nm, which was added to ethylene glycol together with hydroxycinnamic acid extracted from fruit and fused. 3 wt% of zinc oxide and 1 wt% of hydroxycinnamic acid were added to 300 ml of ethylene glycol, and 0.1 wt% of organopolysiloxane was added and stirred for 5 hours at a temperature of 20°C and a speed of 150 rmp. , a transparent composition was prepared while adjusting the pH to 6.5.

Example 2

A composition was prepared in the same manner as Example 1 except that the same amount of titanium dioxide was used.

Example 3

A composition was prepared in the same manner as Example 1, except that the same amounts of zinc oxide and titanium dioxide were used.

Example 4

A composition was prepared in the same manner as Example 1, except that zinc oxide surface-modified by a silane coupling agent was used.

efficacy test

Efficacy tests were conducted on the compositions prepared according to Examples 1 to 4. Efficacy tests were conducted on visible light transmittance, ultraviolet absorbance measurement, ultraviolet ray blocking effect, formulation stability evaluation, and white turbidity improvement effect.

The visible light transmittance of the compositions according to Examples 1 to 4 in the 550 nm wavelength band were as follows.

Example One 2 3 4 Transmittance (550 ㎚) 76.2 78.5 77.8 89.5

The composition according to Example 4 showed the highest visible light transmittance, which appears to be due to the excellent dispersibility of the composition according to Example 4. In the case of Examples 1 to 3, the transmittance of visible light was found to be more than 75%. The ultraviolet ray absorption ability of the composition according to Example 1 in the UV-A and UV-B wavelength bands was measured using a UV-VIS photospectrophotometer. ), and the measurement results are presented in Figure 2. The left side of Figure 2 shows the results of measuring the ultraviolet absorbance of a known organic sunscreen, and the right side of Figure 2 shows the results of measuring the ultraviolet light absorbance of the composition according to Example 1. It can be seen that the composition according to the present invention has excellent absorbance in the entire UV-A and UV-B wavelength range.

A UV-B sensitive yeast bio assay was conducted to test the UV blocking effect, and the results are presented in Figure 3. The test was conducted using an in vitro bio-assay method. For the test, the yeast bacterial solution was smeared on the medium, then the lid of the Petri dish was divided into sections, and the sample in which 0.2 wt% of a simple organic-inorganic mixture was added to the basic sunscreen base was added to the sample in Example 2. A certain amount of 0.2 wt% of the organic-inorganic fusion composite powder was applied. The basic sunscreen base does not contain a sunscreen, and known sunscreens are applied independently in the same amount, and each area is irradiated with UV-B ultraviolet rays for 120 to 300 seconds and incubated in a 35°C incubator for two days to grow bacteria. The level has been confirmed. As shown in Figure 3, growth of bacteria was confirmed in the area where the known sunscreen and the composition according to Example 2 were applied, and it was confirmed that bacteria did not grow in the area where the sunscreen base was applied. In addition, it was confirmed that the growth density of bacteria in the application area according to the example was high.

The SPF (Sun protection Factor) for testing for UV protection was measured, and for measurement, 55.5 cm2 of Transpore Tape was attached to the sample holder, and then 2 mg/cm2 of the composition according to the example was taken and placed on the Transpore Tape. Apply evenly to the non-adhesive surface. 15 minutes after application, the SPF value was measured using an SPF-290 Analyzer, and the measurement results are presented in Table 2. Comparative examples show the test results of known sunscreens.

Example One 2 3 4 Comparison example SPF 45 43 46 48 21

The stability of the composition was tested, and precipitation and browning were tested for stability testing, and the test results are presented in Figure 4. 1 wt% of the composition according to Example 1 and 1 wt% of a known sunscreen were added to an alcohol solvent and left at a temperature of 25 ° C. for 48 hours. The left and right sides of Figure 4 are the composition according to Example 1 and the known sunscreen, respectively. This shows the test results of sunscreen. As can be seen from Figure 4, it was confirmed that in the case of the composition according to the present invention, no sedimentation occurred at the bottom and no browning phenomenon occurred. Sunscreens are functional cosmetics used for skin safety, but cosmetic aspects also need to be considered. In the case of known inorganic sunscreens, when applied to the skin, white clouding and stickiness may occur in the application area due to the inorganic sunscreen material components. The composition according to Example 1 and a known inorganic sunscreen were applied to the skin, and the test results of exposure to outdoor ultraviolet rays at a temperature of 25°C are shown in FIG. 5. The left area corresponds to the area where the composition according to the present invention was applied, and the right area corresponds to the area where a known inorganic sunscreen was applied. As can be seen from Figure 5, it can be seen that the white cloud phenomenon and stickiness are significantly reduced in the case of the composition according to the present invention. Although the present invention has been described in detail above with reference to the presented examples, it is known in the art Those who have this will be able to make various variations and modifications without departing from the technical spirit of the present invention by referring to the presented embodiments. The present invention is not limited by such variations and modifications, but is limited by the claims appended below.

P11: Preparation of inorganic compounds P12: Grinding/Particle size control
P13: Surface treatment P14: Organic compounds
P15: Fusion P16: pH control

Claims (2)

In a composition for blocking ultraviolet rays,
At least one inorganic oxide selected from zinc oxide and titanium dioxide; and
Contains organic compounds having a phenolic group fused to an inorganic oxide,
Phenol groups include hydroxycinnamic acid,
A hybrid composite composition in the form of an organic-inorganic fusion for blocking harmful light, characterized in that the inorganic oxide is surface modified by a silane coupling agent and then coated with an organic compound in the form of a powder. A cosmetic in the form of lotion, emulsion, cream, stick, balm, spray or mist comprising the composition of claim 1.