KR20230075531A - 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법 - Google Patents

거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법 Download PDF

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Publication number
KR20230075531A
KR20230075531A KR1020237017449A KR20237017449A KR20230075531A KR 20230075531 A KR20230075531 A KR 20230075531A KR 1020237017449 A KR1020237017449 A KR 1020237017449A KR 20237017449 A KR20237017449 A KR 20237017449A KR 20230075531 A KR20230075531 A KR 20230075531A
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KR
South Korea
Prior art keywords
bupropion
dosage form
dextromethorphan
human
max
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020237017449A
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English (en)
Korean (ko)
Inventor
헤리엇 타부토
Original Assignee
액섬 테라퓨틱스, 인크.
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Publication date
Application filed by 액섬 테라퓨틱스, 인크. filed Critical 액섬 테라퓨틱스, 인크.
Priority to KR1020247017593A priority Critical patent/KR20240091043A/ko
Publication of KR20230075531A publication Critical patent/KR20230075531A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020237017449A 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법 Ceased KR20230075531A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247017593A KR20240091043A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201862634718P 2018-02-23 2018-02-23
US62/634,718 2018-02-23
US201962794469P 2019-01-18 2019-01-18
US62/794,469 2019-01-18
US201962809480P 2019-02-22 2019-02-22
US62/809,480 2019-02-22
KR1020207027256A KR20210003091A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법
PCT/US2019/019445 WO2019165379A1 (en) 2018-02-23 2019-02-25 Dosage forms and methods for enantiomerically enriched or pure bupropion

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207027256A Division KR20210003091A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247017593A Division KR20240091043A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법

Publications (1)

Publication Number Publication Date
KR20230075531A true KR20230075531A (ko) 2023-05-31

Family

ID=67688503

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020237017449A Ceased KR20230075531A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법
KR1020247017593A Pending KR20240091043A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법
KR1020207027256A Ceased KR20210003091A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020247017593A Pending KR20240091043A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법
KR1020207027256A Ceased KR20210003091A (ko) 2018-02-23 2019-02-25 거울상이성질체적으로 농후한 또는 순수한 부프로피온을 위한 투여 형태 및 방법

Country Status (19)

Country Link
EP (1) EP3755312A4 (enrdf_load_stackoverflow)
JP (3) JP2021513998A (enrdf_load_stackoverflow)
KR (3) KR20230075531A (enrdf_load_stackoverflow)
CN (1) CN112087999A (enrdf_load_stackoverflow)
AU (3) AU2019223187B2 (enrdf_load_stackoverflow)
BR (1) BR112020017179A2 (enrdf_load_stackoverflow)
CA (1) CA3092076A1 (enrdf_load_stackoverflow)
CL (1) CL2020002166A1 (enrdf_load_stackoverflow)
CR (1) CR20200415A (enrdf_load_stackoverflow)
EC (1) ECSP20060179A (enrdf_load_stackoverflow)
IL (2) IL313368A (enrdf_load_stackoverflow)
MA (1) MA51914A (enrdf_load_stackoverflow)
MX (2) MX2020008704A (enrdf_load_stackoverflow)
MY (1) MY202993A (enrdf_load_stackoverflow)
NI (1) NI202000056A (enrdf_load_stackoverflow)
NZ (1) NZ767378A (enrdf_load_stackoverflow)
PE (1) PE20211752A1 (enrdf_load_stackoverflow)
SG (1) SG11202008056SA (enrdf_load_stackoverflow)
WO (1) WO2019165379A1 (enrdf_load_stackoverflow)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL313368A (en) * 2018-02-23 2024-08-01 Axsome Therapeutics Inc Dosage forms and methods for enantiomerically enriched or pure bupropion
US11660273B2 (en) 2018-09-20 2023-05-30 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
US11291639B2 (en) 2018-09-20 2022-04-05 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
US11660274B2 (en) 2018-09-20 2023-05-30 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
WO2021055124A1 (en) * 2019-09-20 2021-03-25 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2318960A1 (en) * 1998-01-29 1999-08-05 Sepracor Inc. Pharmaceutical uses of optically pure (+)-bupropion
US6337328B1 (en) * 1999-03-01 2002-01-08 Sepracor, Inc. Bupropion metabolites and methods of use
DE60330909D1 (de) * 2003-08-08 2010-02-25 Biovail Lab Int Srl Tablette mit modifizierter freisetzung von bupropion hydrochlorid
WO2012118562A1 (en) * 2011-03-02 2012-09-07 Rhine Pharmaceuticals, Llc Compositions and methods for treating depression, adhd and other central nervous system disorders employing novel bupropion compounds, and methods for production and use of novel bupropion compounds and formulations
US10080727B2 (en) * 2013-11-05 2018-09-25 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US9474731B1 (en) * 2013-11-05 2016-10-25 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US9198905B2 (en) * 2013-11-05 2015-12-01 Antecip Bioventures Ii Llc Compositions and methods for reducing dextrorphan plasma levels and related pharmacodynamic effects
WO2015095713A1 (en) * 2013-12-20 2015-06-25 Deuterx, Llc Methods of treating neurological and other disorders using enantiopure deuterium-enriched bupropion
IL313368A (en) * 2018-02-23 2024-08-01 Axsome Therapeutics Inc Dosage forms and methods for enantiomerically enriched or pure bupropion

Also Published As

Publication number Publication date
CA3092076A1 (en) 2019-08-29
KR20240091043A (ko) 2024-06-21
IL276871A (en) 2020-10-29
EP3755312A1 (en) 2020-12-30
BR112020017179A2 (pt) 2020-12-22
CR20200415A (es) 2021-02-03
ECSP20060179A (es) 2020-12-31
NZ767378A (en) 2024-03-22
MX2023009281A (es) 2023-08-17
MY202993A (en) 2024-05-31
JP2024075655A (ja) 2024-06-04
AU2022204521A1 (en) 2022-07-21
CL2020002166A1 (es) 2020-10-23
MA51914A (fr) 2020-12-30
SG11202008056SA (en) 2020-09-29
IL276871B1 (en) 2024-07-01
JP2021513998A (ja) 2021-06-03
AU2019223187A1 (en) 2020-09-17
WO2019165379A1 (en) 2019-08-29
AU2022204521B2 (en) 2024-09-05
AU2024205858A1 (en) 2024-09-05
IL313368A (en) 2024-08-01
EP3755312A4 (en) 2022-03-16
JP2022153638A (ja) 2022-10-12
MX2020008704A (es) 2020-12-07
CN112087999A (zh) 2020-12-15
KR20210003091A (ko) 2021-01-11
AU2019223187B2 (en) 2022-07-28
NI202000056A (es) 2021-01-11
PE20211752A1 (es) 2021-09-06
IL276871B2 (en) 2024-11-01

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Decision date: 20250730

Appeal event data comment text: Appeal Kind Category : Appeal against decision to decline refusal, Appeal Ground Text : 2023 7017449

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Appellate body name: Patent Examination Board

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Decision identifier: 2024101001262