KR20230072221A - Liquefied composition for vaporize and inhale included saponin - Google Patents

Abstract

According to the present invention, a liquid composition for vaporizing inhalation containing a new saponin is disclosed. A pharmaceutical extract containing a large amount of saponin extracted from red ginseng, a pharmaceutical agent, is mixed with eucalyptus oil and peppermint oil in a certain ratio, and vegetable glycerin and propylene glycol are added in a certain ratio as vaporization accelerators to form a vaporizable liquid substance. By vaporizing the vaporizable liquid substance with a vaporizing inhaler and allowing a user to inhale the same through the oral cavity and respiratory organ, a saponin component flows through the bloodstream and is delivered into the cells of human tissue. Accordingly, effects are provided by saponin such as removal and excretion of neutral fat and cholesterol, strengthening liver function, detoxification of heavy metals and various waste products, anti-inflammatory and anticancer activity, prevention of cancer by inhibiting the growth of cancer cells, activation of nerve cells, and subsequent improvement of memory and stabilization of the central nervous system. In addition, neuropsychiatric diseases such as dementia can be prevented through an anti-dementia effect of saponin. Moreover, respiratory diseases such as pneumonia, pulmonary tuberculosis, and asthma can be prevented and alleviated by antiviral and sedative effects of saponin, eucalyptus, and peppermint. The liquid composition of the present invention is manufactured by fermenting dried red ginseng with 50 percent alcohol to extract an extract containing saponin, and based on 30-40 wt% of a pharmaceutical extract obtained by re-concentrating the extract, adding 30 wt% of vegetable glycerin, 20 wt% of propylene glycol, 5-10 wt% of eucalyptus oil, and 5-10 wt% of peppermint oil and mixing evenly.

Description

Liquid composition for vaporization and inhalation containing saponin {Liquefied composition for vaporize and inhale included saponin}

The present invention relates to a liquid composition for vaporization inhalation containing saponin, and more particularly, to a drug extract containing a large amount of saponin extracted from red ginseng, which is a drug, and eucalyptus oil and peppermint oil are mixed at a certain ratio. Then, as vaporization accelerators, vegetable glycerin and propylene glycol are added at a predetermined ratio to prepare a vaporizable liquid substance, which is vaporized with a vaporization inhaler so that the user can inhale it through the mouth and respiratory system, so that the saponin component increases blood flow. Saponin removes and discharges neutral fat and cholesterol, strengthens liver function, detoxifies heavy metals and various wastes, anti-inflammatory and anti-cancer action, prevents cancer by suppressing the growth of cancer cells, and nerve cells. Activation of memory and consequent improvement of memory and stabilization of the central nervous system, and the anti-dementia effect of saponin can prevent neuropsychiatric diseases such as dementia, while the antiviral action of saponin, eucalyptus and peppermint components , It relates to a liquid composition for vaporized inhalation containing saponin to prevent and alleviate respiratory diseases such as pneumonia, tuberculosis, and asthma by sedation.

In general, various technologies have been developed to vaporize a desired substance according to the user's purpose of use so that it can be easily inhaled or to make the desired substance pulverized and then inhaled through the nose. Liquid substances containing spearmint, which can be vaporized and inhaled with a vaporizing inhaler for the purpose of avoidance, or liquid substances containing nicotine, which can be vaporized and inhaled by smokers with a vaporizing inhaler (aka: e-cigarette), are sold on the market. It is becoming.

As an example of a technology for such a composition for inhalation, Patent Registration No. 10-0955080 (name: composition and device for vaporized inhalation, hereinafter referred to as 'Related Technology 1') has been proposed.

The related technology 1 is 'mint, rosemary, basil, peppermint, juniper, geranium, clary sage, ylang ylang, lavender, rosewood, lavender, lemon, chamomile, spearmint, petit grain, pine needle, mire, maychang, At least one substance selected from the group consisting of cinnamon, orange bitters, jasmine, rose, geranium, grapefruit, patchouli, phytoncide, and ginseng extract for vaporization, and at least one selected from propylene glycol, glycerin, or alcohol. The substance is mixed in a weight ratio of 0.5 to 10: 1' as the gist of the technical composition, and if necessary, it is possible to avoid drowsiness while driving by enabling easy vaporization and inhalation using a vaporizing inhaler.

However, since the above-mentioned related technology 1 has an aromatic herbal extract as its main component, it has the effect of temporarily activating the senses of the human body when inhaling vaporization, but it has the effect of temporarily activating the senses of the human body when inhaling vapors. There is a problem that it does not contribute significantly to preventing or alleviating the disease of

On the other hand, as another example of a composition for inhalation, Patent Publication No. 10-2009-0130360 (Name: A pharmaceutical composition for inhalation for the treatment or prevention of asthma and chronic obstructive pulmonary disease containing fibroblast growth factor 2 as an active ingredient, Hereinafter referred to as 'related technology 2') was proposed.

The above-mentioned related technology 2 is 'even if the fibroblast growth factor 2 is administered at a lower dose than the effective dose for intravenous or subcutaneous administration to patients in need of treatment or prevention of asthma and chronic obstructive pulmonary disease, it is equivalent to or better than intravenous or subcutaneous administration. The gist of its technical composition is 'to show efficacy and minimize toxicity or side effects'.

The related art 2 is to inhale the pharmaceutical composition through the nasal cavity through an inhaler, a nebulizer, a dry powder inhaler (DPI), etc. after pulverizing the pharmaceutical composition. It is completely different from vaporization inhalation technology that vaporizes and inhales a liquid composition.

On the other hand, ginseng is a perennial root plant belonging to the genus Ginseng of the family Oga, and about 11 species are known on the earth. Representative species include Korean ginseng (Panax ginseng C. A. Meyer), American ginseng (Panaxquinquefolium L.), There is Panaxjaponicus C. A. Meyer.

The Korean ginseng (Panax ginseng C. A. Meyer) grows wild in the Asian Far East (33-48 north latitude, Korea, northern Manchuria, and parts of Russia) and is known to have excellent medicinal effects, and American ginseng (Panaxquinquefolium L.) is Native to and cultivated in Canada, Panaxnotoginseng F. H. Chen is wild or cultivated from the southeast of Yunnan Province to the southwest of Guangxi Province in China. In addition, Panaxjaponicus C. A. Meyer is distributed in Japan, southwestern China, and Nepal.

As studies on the main components and pharmacological actions of ginseng have been published, it is in the limelight as a natural health food, and its demand is gradually expanding, and it is widely used as a popular natural health food as it is further accelerated by economic growth and the improvement of living standards. It is becoming.

In addition, ginseng has been mainly used in the form of herbal medicine in Asian countries such as Korea for various diseases such as psychiatric and nervous system diseases and diabetes. It has been reported to have an effect on tumor activity.

As a result of years of research on how to utilize red ginseng dried by steaming and cooking ginseng, the present inventors have developed a liquid composition for vaporized inhalation containing saponin according to the present invention.

1. Korean Patent Registration No. 10-0955080, "Vaporized Inhalation Composition and Device". 2. Korean Patent Publication No. 10-2009-0130360, "Pharmaceutical composition for inhalation containing fibroblast growth factor 2 as an active ingredient for treating or preventing asthma and chronic obstructive pulmonary disease".

The present invention is to solve such conventional problems, and the object thereof is to mix eucalyptus oil and peppermint oil in a predetermined ratio with a drug extract containing a large amount of saponin extracted from red ginseng, which is a drug, and vaporization accelerators To provide a new saponin-containing vaporized liquid composition for inhalation prepared as a vaporizable liquid material by adding vegetable glycerin and propylene glycol at a predetermined ratio.

Another object of the present invention is to vaporize the prepared liquid composition with a vaporizing inhaler so that the user can inhale it through the mouth and respiratory tract, so that the saponin component flows through the bloodstream and is delivered into the cells of human tissue, thereby neutralizing fat and cholesterol by saponin removal and discharge, enhancement of liver function, detoxification of heavy metals and various wastes, anti-inflammatory and anti-cancer effects, prevention of cancer by inhibiting the growth of cancer cells, activation of nerve cells and consequent improvement of memory and stabilization of the central nervous system. It prevents and alleviates respiratory diseases such as pneumonia, tuberculosis, and asthma through the antiviral action and sedative action of saponin, eucalyptus and peppermint components. It is to provide a liquid composition for vaporized inhalation containing a new saponin that enables

In order to achieve the above object, the present invention is a drug extract containing a large amount of saponin obtained by fermenting dried red ginseng, which is a drug, in alcohol of 50% alcohol to extract an extract containing saponin, and concentrating the extract extracted by alcohol fermentation again. 30 to 40% by weight of vegetable glycerin, 20% by weight of propylene glycol, 5 to 10% by weight of eucalyptus oil, and 5 to 10% by weight of peppermint oil are added at a rate of 30% by weight and mixed uniformly. have a characteristic

In the present invention, the drug extract is fermented for 60 to 90 days by adding red ginseng at a rate of 1 kg to 3 kg of alcohol of 50% alcohol, and then heated in a water bath for 4 to 6 hours to obtain 1.5 to 2 kg of the extract. It is characterized in that it is obtained by concentrating the bath-bath extract until it reaches a weight of 0.7 to 0.9 kg in a concentrator.

According to the present invention, red ginseng, which is a drug containing very useful ingredients for the human body, is extracted with hot water after alcohol fermentation, and when the water bath extract is concentrated, a drug extract containing a large amount of saponin is extracted, and eucalyptus oil and peppermint oil are extracted from the drug extract. And when vegetable glycerin and propylene glycol, which are vaporization accelerators, are added in a certain ratio and mixed uniformly, a liquid composition that can be inhaled while vaporizing with a vaporization inhaler is prepared.

In addition, when the liquid composition prepared according to the present invention is vaporized with an electronic inhaler and the user inhales it through the oral cavity or respiratory tract, the saponin component flows through the bloodstream and is delivered into the cells of human tissue, helping to remove and discharge neutral fat and cholesterol. It helps, strengthens liver function, and removes heavy metals and various wastes accumulated in the human body to obtain detoxification effects.

In addition, it is helpful in preventing cancer through anti-inflammation and suppression of cancer cell growth by saponin components, as well as improving memory by activating nerve cells and anti-dementia effect by stabilizing the central nervous system, resulting in neuropsychiatric diseases such as dementia. can be prevented, and respiratory diseases such as pneumonia, tuberculosis, and asthma can be prevented and alleviated by the antiviral action and sedation of saponin, eucalyptus and peppermint components.

Hereinafter, preferred embodiments of the present invention will be described in detail.

The saponin-containing liquid composition for vaporization inhalation according to the present invention is a drug containing a large amount of saponin obtained by fermenting dried red ginseng, which is a drug, in 50-degree alcohol to extract a saponin-containing extract, and concentrating the extract. Prepared by adding 30% by weight of vegetable glycerin, 20% by weight of propylene glycol, 5 to 10% by weight of eucalyptus oil, and 5 to 10% by weight of peppermint oil with respect to 30 to 40% by weight of the extract, and then mixing them uniformly do.

In the present invention, the drug extract is fermented for 60 to 90 days by adding 1 kg of red ginseng to 3 kg of alcohol of 50% alcohol, and then 1.5 to 2 kg of extract is extracted by hot water for 4 to 6 hours.

Then, it is obtained by concentrating 1.5 to 2 kg of the water-bath extract in a concentrator until the weight is 0.7 to 0.9 kg.

The red ginseng applied as the main ingredient drug in the present invention is prepared by steaming undried ginseng with steam and then drying it. It is known that the pharmacological efficacy of ginseng is far superior to that of unprocessed ginseng. Recently, these active ingredients of ginseng are easily absorbed into the human body, and as a method of strengthening the components present in ginseng in very small amounts, ginseng is used as a method for enhancing intestinal microbes or lactic acid bacteria. Methods such as fermentation and enzyme treatment using ginseng are used, and it is known that the red ginseng contains a large amount of saponin.

Saponin described above is a glycoside compound produced as a secondary metabolite of steroids and triterpenes. Among them, ginsenoside, a saponin contained in ginseng, enhances and strengthens immunity, enhances vitality in the body, recovers from fatigue, blood circulation, and memory. It shows excellent effects such as improvement and antioxidant, and is known to be effective in rapidly decomposing alcohol in the body to protect the liver, prevent osteoporosis, and prevent and improve hypertension and diabetes.

The eucalyptus applied to the vaporized inhalation liquid composition according to the present invention is native to southern Tasmania, Australia, and is used by collecting fragrant volatile eucalyptus oil from fresh leaves. It is known to be effective in preventing and alleviating respiratory diseases such as rhinitis, cold, asthma, lung disease, allergic rhinitis, sinusitis, and sore throat because it has expectorant and sedative effects.

In particular, cineol component contained in eucalyptus has been confirmed to reduce respiratory inflammation caused by chronic obstructive pulmonary disease (COPD) and asthma, and monoterpene component works together with cineol to have anti-tumor activity of leukocytes. It is known to exhibit anti-inflammatory effects by promoting the production of cytokines, which are factors.

The peppermint applied to the vaporized inhalation liquid composition according to the present invention has a strong fragrance and a refreshing feeling, so it is mint used in gum or toothpaste, and is effective for stomach, belching, indigestion, allergic rhinitis, etc. It is known to act on the nervous system to promote the secretion of dopamine, a substance in the brain, to refresh the mood, and to have a sedative effect, releasing muscle tension and suppressing spasms.

In addition, menthol contained in peppermint acts to relieve chest pain and breathing due to coughing, promotes the secretion of pain-relieving nerve substances in the body, prevents the formation of substances that cause pain, and has strong antibacterial action. It is known to act to prevent oral diseases.

On the other hand, vegetable glycerin, which is added as a vaporization accelerator in the present invention, is a colorless and odorless liquid obtained from oil palm, which is a coconut fruit, and has a sweet taste and functions as a solvent responsible for the amount of atomization.

Propylene glycol described above is a colorless, transparent, syrup-like liquid that has no odor or a slight odor, and is a solvent with a slightly bitter and sweet taste. It was also used as a solvent for food by the FDA in 1941 because it prevented the propagation of mold and did not ferment.

Accordingly, propylene glycol is used as a softener for food, cellophane, and cork, and is also used as an emulsification stabilizer for emulsified spices, a preservative, and air sterilization, and is also used for extraction of natural flavors such as vanilla beans.

The liquid composition for vaporization inhalation containing saponin according to the present invention is inhaled while being vaporized through a vaporization inhaler. When electric current is applied, the electric heating coil heats up and vaporizes the liquid composition stored in the cutter, and the user uses it by inhaling the vaporized liquid composition through a separate suction pipe.

When the vaporized liquid composition is inhaled into the human body through the user's mouth and respiratory system, the saponin component flows through the bloodstream and is delivered into the cells of human tissue, helping to remove and discharge neutral fat and cholesterol, strengthening liver function, , heavy metals and various wastes accumulated in the human body are removed, and detoxification effects can be obtained.

In addition, it is helpful in preventing cancer through anti-inflammation and suppression of growth of cancer cells by saponin components, as well as improvement of memory by activating nerve cells and anti-dementia effect by stabilizing the central nervous system, resulting in neuropsychiatric diseases such as dementia can be prevented, and respiratory diseases such as pneumonia, tuberculosis, and asthma can be prevented and alleviated by the antiviral action and sedation of saponin, eucalyptus and peppermint components.

Example 1 : Preparation of drug extract containing saponin component

Dried red ginseng was added at a rate of 1 kg to 3 kg of 50% alcohol, fermented for 90 days, and then heated in a water bath for 6 hours to obtain 2 kg of an extract. A drug extract was obtained.

Example 2 : Preparation of liquid composition for vaporization inhalation

Based on 40 g of the drug extract obtained in Example 1, 30 g of vegetable glycerin and 20 g of propylene glycol. After adding 5 g of eucalyptus oil and 5 g of peppermint oil, they were evenly mixed to prepare a vaporized inhalation liquid composition containing 100 g of saponin.

Example 3 : Use of liquid composition for vaporization inhalation containing manufactured saponin

After purchasing a commercially available vaporizing inhaler, it was vaporized while storing 3 mg of the liquid composition prepared in Example 2 inside the cartomizer. state was indicated.

In addition, when the vaporized liquid composition was inhaled, the herbal scent unique to eucalyptus and peppermint was primarily felt, and the throat area was refreshed and the head was clear.

Claims (2)

Dried red ginseng is fermented with 50% alcohol to extract an extract containing saponin, and 30 to 40% by weight of vegetable glycerin, 20% by weight of propylene glycol, eucalyptus based on 30 to 40% by weight of the drug extract obtained by concentrating the extract again A liquid composition for vaporized inhalation containing saponin, characterized in that it is prepared by adding 5 to 10% by weight of oil and 5 to 10% by weight of peppermint oil and then uniformly mixing. According to claim 1,
The drug extract was fermented for 60 to 90 days by adding dried red ginseng to 3 kg of 50-degree alcohol at a rate of 1 kg, and then soaked in hot water for 4 to 6 hours to obtain 1.5 to 2 kg of extract;
A liquid composition for vaporized inhalation containing saponin, characterized in that obtained by concentrating the 1.5 to 2 kg of the bath extract in a concentrator until the weight is 0.7 to 0.9 kg.