KR20230061325A - Novel coronavirus recombinant spike protein, polynucleotide encoding the protein, vector comprising the polynucleotide, and vaccine for preventing or treating coronavirus infection comprising the vector - Google Patents

Abstract

The present invention relates to a novel coronavirus recombinant spike protein, a polynucleotide encoding the same, a vector containing the polynucleotide, and a vaccine for preventing or treating coronavirus infection comprising the vector. The coronavirus recombinant spike protein of the present invention is stable and does not degrade well in cells, and effectively activates immune cells, resulting in high antibody production and T cell reactivity, and the vector of the present invention has high antigen expression, resulting in antibody production And since it was confirmed that T cell reactivity was high, antibody production expression period was long, and hepatotoxicity was not shown, it can be usefully used as a vaccine for preventing or treating coronavirus infection.

Description

A novel coronavirus recombinant spike protein, a polynucleotide encoding the same, a vector comprising the polynucleotide, and a vaccine for preventing or treating coronavirus infection comprising the vector polynucleotide, and vaccine for preventing or treating coronavirus infection comprising the vector}

The present invention relates to a novel coronavirus recombinant spike protein, a polynucleotide encoding the same, a vector containing the polynucleotide, and a vaccine for preventing or treating coronavirus infection comprising the vector.

Coronaviruses, which cause severe respiratory illness and cause death, are classified as RNA viruses belonging to Coronaviridae, and are defined as respiratory syndrome caused by coronavirus infection. Among the viruses belonging to Coronaviridae, there are a total of 7 viruses known to infect humans: 4 types that cause colds (229E, OC43, NL63, HKU1), 2 types that cause severe pneumonia (SARS-CoV, MERS-CoV), and this time There is SARS-CoV-2, the virus responsible for the pandemic. The three viruses (SARS-CoV, MERS-CoV, and SARS-CoV-2) that cause severe pneumonia, starting with SARS-CoV in 2002 and followed by MERS-CoV in 2012, are highly homologous in gene sequence with SARS-CoV. Until the current SARS-CoV-2, a global pandemic is underway.

Coronaviruses (Coronaviridae) have unstable RNA in their genome, so mutations easily occur, and due to these characteristics, there is a possibility of transmission in both animals and humans. According to studies to date, SARS-CoV has been transmitted from civet cats to humans, MERS-CoV has been transmitted from dromedary camels to humans, and judging from these cases, coronaviruses from other species that use animals as hosts are strains that infect humans. It has the potential to evolve into a virus.

SARS-CoV-2 was first reported in late 2019. Compared to SARS-CoV that occurred in China in 2002, SARS-CoV has a higher severity, but SARS-CoV-2 has a much higher transmissibility. are doing This has resulted in a worldwide pandemic. Common signs of infection include respiratory symptoms, fever, cough, shortness of breath and shortness of breath. In more severe cases, infection can cause pneumonia, severe acute respiratory syndrome, kidney failure and even death.

Numerous countries and organizations are currently working to develop a vaccine to eradicate the COVID-19 pandemic. Types of preventive vaccines include inactivated vaccines, live attenuated vaccines, protein subunit vaccines, viral vector based vaccines, DNA vaccines, and mRNA vaccines, depending on the manufacturing method. are classified Inactivated vaccines and attenuated live vaccines, which have traditionally been widely used as vaccine formulations, have the advantage of simple manufacturing processes, but in the case of inactivated vaccines, they do not induce a high level of immune response, and live attenuated vaccines have mutations. There is a risk of re-acquisition of pathogenicity through Since protein subunit vaccines do not induce an immune response well, there is a problem in that an immune enhancer must be used together.

With the development of biotechnology, new platform vaccine formulations have begun to be developed, one of which is a viral vector based vaccine. Vector-based vaccines activate the immune response by delivering vaccine antigen genes to human cells with high efficiency, allowing the body to produce antigen proteins on its own. Viral vector-based vaccines are safe, and since they induce a high level of immune response, efficient immunization is possible with just a single administration without the need for repeated administration. In addition, it has the advantage of efficiently inducing cytotoxic T cell immunity as well as antibody production based on the virus structurally. Many viruses are being studied as gene vectors, and among them, Adenovirus is widely used in the field of gene therapy because it is easy to manipulate and safety has been verified through a lot of research. Because it can be delivered, it has high competitiveness compared to other viral vectors.

Adenovirus is a linear, double-stranded DNA virus, 70-90 nm in diameter, with an unenveloped, icosahedral capsid, which is formed by 240 hexons, 12 pentons and fibers extending from the vertices of each icosahedron. These hexons, pentones and fibers determine the mainstream adenovirus antigens and their serotypes. The adenovirus genome is approximately 30-45 kb in size and has four early regions (E1, E2, E3 and E4) and five late regions (L1-L5). Adenoviruses are good candidates as recombinant vectors for vaccine production because they are highly infective and many of them are not pathogenic. In addition, adenoviral vectors can efficiently translate large genes and prolong the immune response in animals. Adenoviral vectors are mainly used in a form in which the E1 gene responsible for self-replication is removed, and the adenoviral vectors with the E1 gene removed are safe because they do not cause pathogenicity in the body because self-replication is impossible in human cells.

The Ad5/35 vector is a form in which a knock gene of replication-defective adenovirus serotype 5 (Ad5) is substituted with a knock gene of adenovirus serotype 35 (Ad35). Through this modification, the Ad5/35 vector can be introduced into cells through the CD46 receptor, which is highly expressed in human immune cells, rather than the cell receptor for Ad5. That is, Ad5/35 can be efficiently introduced into human antigen-presenting cells and can be an efficient vaccine platform capable of maximizing antigen production. In addition, it has been reported that the Ad5/35 vector has a significantly lower risk of liver toxicity compared to the Ad5 vector. In fact, the present inventors have confirmed in preclinical and clinical trials that a high level of immune response is induced when cancer antigen genes are delivered to cancer patients using adenoviral vectors, and when administered to a large number of patients in clinical trials, safety and toxicity It was confirmed that no related problems occurred.

A consideration when preparing a vaccine candidate is the stability of the expressed antigen. It is important that vaccine antigens are secreted in large amounts, but even if they are expressed, if they are rapidly degraded at an early stage, there is a concern that immune cells may not be effectively activated. Therefore, it is important to stably maintain the antigen for a long period of time.

Accordingly, in order to develop a vaccine for preventing or treating COVID-19, the inventors of the present invention, the S1 gene encoding the spike protein that plays a key role in cell infection of SARS-CoV-2 A polynucleotide in which the cleavage site located between and S2 was substituted with a linker sequence was introduced into a vector to prepare a preventive or therapeutic vaccine, and the vaccine produced an amount of antibody against SARS-CoV-2 and T cell reactivity This high was confirmed and the present invention was completed.

An object of the present invention is to provide a novel coronavirus recombinant spike protein, a polynucleotide encoding the same, a vector containing the polynucleotide, and a vaccine for preventing or treating coronavirus infection comprising the vector.

In order to achieve the above object, the present invention provides a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

In addition, the present invention provides a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

In addition, the present invention provides a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

In addition, the present invention provides a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

In addition, the present invention provides a vector comprising a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein has been removed and a linker sequence has been introduced.

In addition, the present invention provides a vector comprising a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein has been removed and a linker sequence has been introduced.

In addition, the present invention provides a vector characterized in that the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein is removed and a polynucleotide encoding a recombinant spike protein into which a linker sequence is introduced is introduced into adenovirus.

In addition, the present invention provides a vector characterized in that the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein is removed and a polynucleotide encoding a recombinant spike protein into which a linker sequence is introduced is introduced into the Ad5/35 virus. do.

In addition, the present invention is characterized by introducing a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein has been removed and a linker sequence has been introduced into the Ad5/35 virus vector is provided.

In addition, the present invention provides a vaccine for preventing or treating coronavirus infection comprising a vector containing polynucleotides of the S1 and S2 genes of the coronavirus spike protein.

In addition, the present invention provides a vaccine for preventing or treating coronavirus infection comprising a vector containing polynucleotides of the S1 and S2 genes of the SARS-CoV-2 spike protein.

In addition, the present invention provides a vaccine for preventing or treating coronavirus infection, characterized by introducing polynucleotides of S1 and S2 genes of SARS-CoV-2 spike protein into adenovirus.

In addition, the present invention provides a vaccine for preventing or treating coronavirus infection, characterized in that polynucleotides of the S1 and S2 genes of the SARS-CoV-2 spike protein are introduced into the Ad5/35 virus.

In addition, the present invention is a vector characterized in that the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and the polynucleotide into which the linker sequence is introduced is introduced into the Ad5/35 virus. A vaccine for preventing or treating coronavirus infection-19 (COVID-19) is provided.

The present invention relates to a novel coronavirus recombinant spike protein, a polynucleotide encoding the same, a vector containing the polynucleotide, and a vaccine for preventing or treating coronavirus infection comprising the vector. The coronavirus recombinant spike protein of the present invention is stable and does not degrade well in cells, and effectively activates immune cells, resulting in high antibody production and T cell reactivity, and the vector of the present invention has high antigen expression, resulting in antibody production And since it was confirmed that T cell reactivity was high, antibody production expression period was long, and hepatotoxicity was not shown, it can be usefully used as a vaccine for preventing or treating coronavirus infection.

1 is based on Adenovirus serotype 5, the E3 gene region, which is the receptor binding site, is substituted with the fiber gene of Adenovirus serotype 35, and SARS-CoV It is a schematic diagram showing the vaccine for preventing or treating COVID-19 according to the present invention loaded with spike protein, which plays a key role in cell infection of -2, as an antigen.
Figure 2 shows that the vaccine for preventing or treating COVID-19 of the present invention has high structural stability and antigen expression, and antibody generation B It is a schematic diagram showing that the cell has an excellent ability to produce neutralizing antibodies.
Figure 3 is a schematic diagram showing the mechanism of action of the vaccine for preventing or treating COVID-19 of the present invention.
4 is a schematic diagram showing a control expression vector constructed using the genome of Adenovirus type 5 (Ad5).
5 is a schematic diagram showing adenovirus #1 to #4 vectors loaded with spike protein antigens, which are antigen expression genes.
6 is a diagram showing antigen expression levels when adenovirus #1 to #4 vectors loaded with spike protein antigens, which are antigen expression genes, were introduced into cultured cell lines.
FIG. 7 is a diagram showing the expression levels of antigens released outside cells when adenovirus #1 to #4 vectors loaded with spike protein antigens, which are antigen expression genes, are introduced into cultured cell lines.
8 is a diagram showing the amount of antibody production after injecting adenovirus #1 to #4 vectors loaded with spike antigen, which is an antigen expression gene, into mice.
9 is a diagram showing the amount of antigen-specific antibodies present in the blood after injection of an adenovirus # 3 vector loaded with a spike antigen, which is an antigen expression gene, into mice.
10 is a diagram showing the amount of antibody production after injecting an adenovirus # 3 vector loaded with a spike antigen, which is an antigen expression gene, into monkeys.
11 is a diagram showing the concentration of neutralizing antibodies after injecting an adenovirus # 3 vector loaded with a spike antigen, which is an antigen expression gene, into monkeys.
12 is a diagram showing liver toxicity levels in blood after injection of adenovirus # 1 to # 4 vectors loaded with spike antigens, which are antigen expression genes, in monkeys.
13 is a diagram showing T cell reactivity in spleen cells and peripheral blood mononuclear cells (PBMC) after injection of adenovirus # 1 to # 3 vectors loaded with spike antigens, which are antigen expression genes, into mice.
14 is a diagram showing T cell reactivity in peripheral blood mononuclear cells (PBMC) after injection of an adenovirus # 3 vector loaded with a spike antigen, which is an antigen expression gene, into primates.
15 shows similar levels of neutralizing antibodies when mice were injected with #3 vector expressing the spike antigen prepared in Example 3 or a vector in which the E4 gene among the adenovirus genes of the #3 vector was rearranged into the E1 region of the viral genome. It is also confirmed that the production of
16 shows similar levels of neutralizing antibodies when monkeys were injected with #3 vector expressing the spike antigen prepared in Example 3 or a vector in which the E4 gene among the adenovirus genes of the #3 vector was rearranged into the E1 region of the viral genome. It is also confirmed that the production of

Hereinafter, the present invention will be described in detail.

The present invention provides a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The coronavirus is characterized in that it is SARS-CoV, MERS-CoV or SARS-CoV-2 belonging to the genus beta coronavirus.

The genome homology between SARS-CoV-2 and SARS-CoV is 79.6%, and the genome homology between SARS-CoV-2 and MERS-CoV is as high as 50%. In particular, while SARS-CoV-2 and MERS-CoV have a similar spike protein homology of 35%, which is the target of the invention, the spike protein homology of SARS-CoV-2 and SARS-CoV is very high at 76%. to be

In addition, the present invention provides a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

In vaccines, it is important that antigens are secreted in large amounts, but even if they are expressed in large amounts, if they are initially degraded, they do not stimulate immune cells to sufficiently induce an immune response, so it is very important that the expressed antigens have high stability. The recombinant spike protein of the present invention, in which the linker sequence is linked between S1 and S2, has high antigen expression and improved stability, and thus has excellent ability to generate neutralizing antibodies and induce T cell reactivity.

The term "immune response" may include, but is not limited to, humoral and cellular immune responses, such as CD4+ or CD8+ cell activation.

The spike protein antigen linked by the linker sequence is characterized by increased antigen expression.

The spike protein (S protein) covers the surface of coronavirus particles and is a protrusion-shaped protein used when coronavirus invades human cells. It is composed of subunits of S1 and S2 and is an angiotensin converting enzyme After combining with -2 (Angiotensin Converting Enzyme 2, ACE-2) receptor, it penetrates into cells and pushes genetic material (RNA) to infect the human body by replicating itself.

The recombinant protein is characterized in that the cleavage site between the S1 and S2 genes, which are subunits of the spike protein, is removed.

The protein is characterized in that the cleavage recognition sequence between the S1 and S2 genes is removed and linked to a linker sequence.

The linker is characterized in that it consists of (GGGGS)n, wherein n is an integer from 1 to 5.

The domains constituting each protein have a distance (linker sequence length) optimized for interaction according to their unique characteristics, and the structural stability of the protein is expressed according to the length of the linker sequence. Thus, the protein preferably has n between 1 and 3, most preferably n is 1.

When n exceeds 4, a large number of repetitive sequences are generated, and the linker sequence may be deleted by unintentional homologous recombination, and the stability of the protein may be reduced.

The spike protein antigen linked by the linker sequence is characterized by increased stability.

The linker sequence is characterized by consisting of SEQ ID NO: 19 or SEQ ID NO: 20.

All coronaviruses have a spike protein in common, and the spike protein is composed of S1 and S2 subunits, so all spike proteins of coronaviruses can be used.

All Spike proteins in which the cleavage recognition sequence between the S1 and S2 genes of these Spike proteins is removed and connected by a linker belong to this invention.

Coronaviruses include 229E, OC43, NL63, and HKU1, which cause colds, and SARS-CoV, MERS-CoV, and SARS-CoV-2, which cause severe pneumonia, and all of these spike proteins are available.

Preferably, it is a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the spike protein of SARS-CoV-2 is removed and a linker sequence is introduced.

The recombinant spike protein may additionally include an adjuvant to improve immunogenicity, and the adjuvant is GM-CSF, IL-17, IFNNg, IL-15, IL-5, JNK, NFkB, NKKKKLIGAND , PD1/2, NKKKKG2B, NKG2C, NKKKKG2E, NKKKK2F, TAPAPAP2, and functional fragments thereof, E-selectin, IL-α, IL-6, INF-γ, Lympmpmphotoxin α, hGH-1, MIPPP1, IL-7, IL -8, APP, IRARAK, IkB, KILILUX, TRAIL-1, IL-1, AIR, and functional fragments of ICAM-1, ICAM-1, TAP2, CD40, TAP1, TRAILrecDRC5, CD34, CD40L, DR3, GlyCAM1, p55 , CD2, Ox40, TRAF6, DR4, ICAM3, DR5, MyD88, p65Rel, pl5095, p38, CPG, and TLR.

The adjuvant may be linked to the C-terminus of the recombinant Spike protein.

In addition, the present invention provides a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The coronavirus is characterized in that it is SARS-CoV, MERS-CoV or SARS-CoV-2.

In addition, the present invention provides a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

The linker is characterized in that it consists of 9 to 45 bases, preferably consists of 9 to 21 bases, and more preferably consists of 15 bases.

A polynucleotide encoding a spike protein linked by the linker sequence is characterized by increased stability.

The polynucleotide encoding the spike protein linked by the linker sequence is characterized by increased antigen expression.

The linker sequence is characterized by consisting of SEQ ID NO: 11 or SEQ ID NO: 15.

The polynucleotide may be SEQ ID NO: 12 or 16.

In addition, the present invention provides a vector comprising a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein has been removed and a linker sequence has been introduced.

The coronavirus is characterized in that it is SARS-CoV, MERS-CoV or SARS-CoV-2.

In addition, the present invention provides a vector comprising a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein has been removed and a linker sequence has been introduced.

In addition, the present invention provides a vector characterized in that the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein is removed and a polynucleotide encoding a recombinant spike protein into which a linker sequence is introduced is introduced into adenovirus.

In addition, the present invention is a vector characterized by introducing a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein has been removed and a linker sequence has been introduced into adenovirus. to provide.

The cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein has been removed and the polynucleotide encoding the recombinant spike protein into which the linker sequence has been introduced has been introduced into adenovirus. The vector may be SEQ ID NO: 27 or 29 .

In addition, the present invention provides a vector characterized in that the cleavage recognition sequence between the S1 and S2 genes of the coronavirus spike protein is removed and a polynucleotide encoding a recombinant spike protein into which a linker sequence is introduced is introduced into the Ad5/35 virus. do.

In addition, the present invention is characterized by introducing a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein has been removed and a linker sequence has been introduced into the Ad5/35 virus vector is provided.

In the present invention, "vector" refers to a carrier loaded with cloned genes (or other fragments of cloned DNA) and transported to target cells.

The vector may be any one selected from the group consisting of plasmids and viruses.

Specific examples of plasmid DNA include commercial plasmids such as pCMV3, pET28a and pET. Other examples of plasmids that can be used in the present invention include Escherichia coli-derived plasmids (pCMV3, pET28a, pET, pGEX, pQE, pDEST and pCOLD), Bacillus subtilis -derived plasmids (pUB110 and pTP5) and yeast-derived plasmids. There are plasmids (YEp13, YEp24 and YCp50). Since these plasmids show different amounts of protein expression and modification depending on the host cell, a host cell most suitable for the purpose may be selected and used.

All known viruses that can be used as vectors can be used as the virus, and adenovirus, retrovirus, lentivirus, adeno-associated virus (AAV), modified vaccinia virus ankara (MVA), herpes simplex virus, It may be any one of Baculoviruses, but is not limited thereto. According to a specific embodiment of the present invention, the virus is preferably an adenovirus.

As used herein, the term “adenoviral vector” refers to an adenovirus that has been engineered such that the adenovirus genome has nucleic acid sequences that are non-native with respect to the adenovirus genome. Thus, a "recombinant adenoviral vector" as used herein is typically a recombinant spike in which the adenovirus genome and necessary proteins (e.g., the spike protein of SARS-CoV-2 or the cleavage recognition sequence between S1 and S2 are replaced with a linker sequence). an expression cassette comprising at least one foreign nucleic acid sequence encoding a protein).

Adenoviral vectors preferably contain at least a portion of each terminal repeat required to support replication of viral DNA, preferably at least about 90% of a completely inverted terminal repeat (ITR) sequence, and It contains the DNA required to encapsidate the genome into the viral capsid. Adenoviruses from a variety of origins can be used as a source of viral genome for adenoviral vectors. Human adenovirus, e.g., subgroup A (eg, serotypes 12, 18 and 31), subgroup B (eg, serotypes 3, 7, 11, 14, etc.), subgroup C (eg, serotypes 1, 2, 5, and 6), subgroup D (eg serotype 8, 9, 10, 13, 15, 17, 19, 20, etc.), subgroup E (eg serotype 4), subgroup F (eg serotypes 40 and 41) and others are preferred. Preferably, the adenoviral vector is a vector of human subgroup C, in particular serotype 2, even more preferably serotype 5.

Adenoviral vectors may be replication competent vectors. Typically, adenoviral vectors are replication-defective vectors in the host cell. The term “replication-defective” means that an adenoviral vector has a deficiency in one or more gene functions or regions (e.g., E1, E3 or E4 regions) of the adenoviral genome for replication such that the vector has no low level of It means to keep replicating or not to replicate in normal host cells, especially those in humans infected with adenoviral vectors. Replication-deficient adenoviral vectors ensure the safety of vaccines. In one embodiment, the adenoviral vector is a vector with E1 or E3 or both removed. A deficiency in a gene completely eliminates or impairs the function of the gene, eg, reducing the function of the gene product by at least about 2-fold, 5-fold, 10-fold, 20-fold or more relative to the native gene. It is defined as a mutation or deletion to cause The resulting replication-defective adenoviral vector is capable of accepting one or more exogenous nucleic acid sequences at appropriate sites within the adenoviral genome for expression of one or more desired proteins, while retaining the ability to be packaged into an adenoviral capsid. For the purpose of generating high titers of viral vectors for stock solutions, replication-deficient adenoviral vectors are typically prepared in complementing cell lines, such as HEK293 or HEK293R cells, that provide gene function not present in replication-deficient adenoviral vectors. is produced

The adenovirus is adenovirus serotype 2 (Ad2), adenovirus serotype 4 (Ad4), adenovirus serotype 5 (Ad5), adenovirus serotype 11 (Adenovirus serotype 11, Ad11), Adenovirus serotype 26, Ad26, Adenovirus serotype 35, Ad35, Chimpanzee adenovirus serotype 68, ChAd68, avian adenovirus It may be Fowl adenovirus serotype 9 (FAd9) or Porcine Adenovirus serotype 3 (PAd3).

The adenovirus may be a modified form based on Ad5.

The adenovirus may be an adenovirus (Ad5/35) in which the knob gene of adenovirus serotype 5 (Ad5) is replaced with the knob gene of adenovirus serotype 35 (Ad35).

The adenovirus is characterized in that the E1 gene and the E3 gene are deleted.

The adenovirus may have a form in which part or all of the E4 gene is deleted and the E4 gene is rearranged to the E1 region in addition to the deletion of the E1 gene and the E3 gene.

The adenovirus is characterized in that it is introduced into cells through the CD46 receptor, which is highly expressed in human immune cells.

The adenovirus is characterized by a low hepatotoxicity-inducing effect.

The adenovirus is characterized by high antigen expression.

In addition, the present invention provides a vaccine for preventing or treating coronavirus infection comprising a vector containing polynucleotides of the S1 and S2 genes of the coronavirus spike protein.

The coronavirus may be any one selected from the group consisting of SARS-CoV, MERS-CoV and SARS-CoV-2.

The vector may use any known virus that can be used as a vector, and any one of adenovirus, retrovirus, lentivirus, adeno-associated virus (AAV), and modified vaccinia virus ankara (MVA) It may, but is not limited thereto. According to a specific embodiment of the present invention, the virus is preferably an adenovirus.

The adenovirus is adenovirus serotype 2 (Ad2), adenovirus serotype 4 (Ad4), adenovirus serotype 5 (Ad5), adenovirus serotype 11 (Adenovirus serotype 11, Ad11), Adenovirus serotype 26, Ad26, Adenovirus serotype 35, Ad35, Chimpanzee adenovirus serotype 68, ChAd68, avian adenovirus It may be Fowl adenovirus serotype 9 (FAd9) or Porcine Adenovirus serotype 3 (PAd3).

The adenovirus may be a modified form based on Ad5.

The adenovirus may be an adenovirus (Ad5/35) in which the knob gene of adenovirus serotype 5 (Ad5) is replaced with the knob gene of adenovirus serotype 35 (Ad35).

The adenovirus is characterized in that the E1 gene and the E3 gene are deleted.

The adenovirus may have a form in which part or all of the E4 gene is deleted and the E4 gene is rearranged to the E1 region in addition to the deletion of the E1 gene and the E3 gene.

The adenovirus is characterized in that it is introduced into cells through the CD46 receptor, which is highly expressed in human immune cells.

In addition, the present invention provides a vaccine for preventing or treating coronavirus infection comprising a vector containing polynucleotides of the S1 and S2 genes of the SARS-CoV-2 spike protein.

In addition, the present invention provides a vaccine for preventing or treating coronavirus infection, characterized by introducing polynucleotides of S1 and S2 genes of SARS-CoV-2 spike protein into adenovirus.

In addition, the present invention provides a vaccine for preventing or treating coronavirus infection, characterized in that polynucleotides of the S1 and S2 genes of the SARS-CoV-2 spike protein are introduced into the Ad5/35 virus.

In addition, the vaccine of the present invention can be prepared as an oral or parenteral formulation, and can be administered by an intradermal, intramuscular, or intranasal route, preferably an intramuscular route.

The vaccine of the present invention is characterized in that the cleavage site between the S1 and S2 proteins is removed.

The vaccine is characterized in that the cleavage recognition sequence between S1 and S2 of the spike protein is removed and connected to a linker sequence.

The linker is characterized in that it consists of 9 to 45 bases, preferably consists of 9 to 21 bases, and more preferably consists of 15 bases.

In addition, the present invention provides a method for preventing or treating coronavirus infections including COVID-19, severe acute respiratory syndrome (SARS or Middle East respiratory syndrome (MERS)) by administering the vaccine to a subject.

In the present invention, "individual" means all animals, including humans, that can be infected with coronavirus. By administering the vaccine of the present invention to a subject, the above diseases can be effectively prevented. For example, the vaccine of the present invention can prevent humans from coronavirus.

In the present invention, "prevention" means any action that suppresses or delays the onset of coronavirus infection by administering a vaccine.

In the present invention, "treatment" means any action that removes coronavirus or alleviates symptoms caused by coronavirus by administering a vaccine.

The vaccine of the present invention is administered in a pharmaceutically effective amount. The term "pharmaceutically effective amount" means an amount sufficient to treat a disease with a reasonable benefit/risk ratio applicable to medical treatment, and the effective dose level is dependent on the type and severity of the subject, age, sex, infected virus type, drug activity, drug sensitivity, administration time, route of administration, excretion rate, duration of treatment, factors including concurrently used drugs, and other factors well known in the medical field. The vaccine of the present invention may be administered as an individual therapeutic agent or in combination with other therapeutic agents, and may be administered sequentially or simultaneously with conventional therapeutic agents. And it can be single or multiple administrations. It is important to administer the amount that can obtain the maximum effect with the minimum amount without side effects in consideration of all the above factors, and can be easily determined by those skilled in the art.

The term "effective amount" refers to a dose sufficient to provide the desired therapeutic effect in the subject being treated, eg sufficient to generate or induce an immune response against a pathogen or antigen in its receptor. The effective amount may vary for various reasons, such as the route and frequency of administration, the body weight and species of the individual receiving the drug, and the purpose of administration. A person skilled in the art can determine the dosage in each case based on the disclosure herein, established methods and their own experience. For example, in certain embodiments, a recombinant adenoviral vector of the invention comprises between 1×10 ⁹ and 1×10 ¹² viral particles (VP), eg, 1×10 ⁹ , 1×10 ¹⁰ , 1×10 ¹¹ , or 1×10 ¹² VP.

In a specific embodiment of the present invention, the present inventors use a polynucleotide in which the cleavage recognition sequence between S1 and S2 of the polynucleotide encoding the spike protein of SARS-CoV-2 belonging to the coronavirus is substituted with a linker sequence to E1 of adenovirus. and E3 genes were deleted, and a vector introduced into an adenovirus in which a fiber, a cell receptor binding site of adenovirus serotype 5, was substituted with a fiber of serotype 35 was prepared (see FIG. 4), and the vector It was confirmed that antigen expression level, antibody production amount and T cell reactivity were high, antibody production expression period was long, and no liver toxicity was observed (FIGS. 6, 7, 9, 12, 13, and 14). In addition, vaccines prepared by loading antigens into Ad5/35 vector as well as vectors in which part or all of the E4 gene was deleted in addition to the E1 gene and E3 gene deletion and the E4 gene was rearranged into the E1 region were administered to mice and monkeys. It was confirmed that the amount of neutralizing antibody produced was similar to that of the vaccine in which the antigen was loaded into the Ad5/35 vector (FIGS. 15 and 16).

Therefore, the recombinant coronavirus spike protein of the present invention is stable and does not degrade well in cells, effectively activates immune cells and has high antibody production and T cell reactivity, and the vector of the present invention has high antigen expression, Since it was confirmed that the amount of antibody production and T cell reactivity was high, the period of expression of antibody production was long, and that hepatotoxicity was not shown, it can be usefully used as a vaccine for preventing or treating coronavirus infection.

The present invention is explained in detail by the following Examples and Experimental Examples.

However, the following Examples and Experimental Examples are only to illustrate the present invention, and the content of the present invention is not limited by the following Examples and Experimental Examples.

< Example 1> Construction of control expression vector (plasmid #1 vector)

A plasmid containing the adenovirus sequence (SEQ ID NO: 21) without spike protein antigen was named pAdk35F (SEQ ID NO: 1, 34,030 bp) and was constructed using the genome of Adenovirus type 5 (Ad5) . pAdk35F includes an adenovirus in which the E1 and E3 genes of adenovirus are deleted, and a fiber, which is a cell receptor binding site of adenovirus serotype 5, is substituted with a fiber of serotype 35. The CMV (Cytomegalovirus) promoter, tetracycline operator (Tet O), restriction enzyme SwaI site, and SV40 poly A sequence are loaded into the E1 gene deletion site of pAdk35F.

As shown in FIG. 4, the pCMV3-SARS-CoV-2 (Spike ORF) vector (Sino Biological, Cat. #: VG40589-UT, SEQ ID NO: 2, 9,858 bp) loaded with a polynucleotide encoding spike protein, an antigen expression gene. ) as a template, the extracellular domain of the spike protein antigen gene was amplified using the spike protein antigen amplification primer set in Table 1 below, and then the pAdk35F vector cut with the restriction enzyme SwaI and in-fusion cloning ligation (in-fusion cloning ligation, Clontech, Cat. #: 639648) to construct a control expression vector, plasmid #1 vector (SEQ ID NO: 22). The part encoding the spike protein in the plasmid #1 vector is shown in SEQ ID NO: 3, and the nucleotide sequence of the adenovirus into which the spike protein has been introduced is shown in SEQ ID NO: 23.

Sequence (5'→3') sequence number forward primer TCC AGC CTC CGA TTT GCC ACC ATG TTT GTG TTC CTG G 4 reverse primer GAT TAT GAT CAA TTT TCA TGG CCA CTT GAT GTA TTG TTC 5

< Example 2> Construction of an improved spike antigen expression vector

<2-1> Construction of an improved spike antigen expression vector (plasmid #2 vector)

The cleavage recognition sequence (SEQ ID NO: 6, amino acid sequence: TNSPRRAR) of domains S1 and S2 of the spike protein antigen of the pCMV3-SARS-CoV-2 (Spike ORF) vector used as a template for the polymerase chain reaction in Example 1 above pCMV3-SARS-CoV-2 (Spike IL) was also substituted with the TILR (Thr-Ile-Arg-Leu) sequence (SEQ ID NO: 7) with the primer set shown in Table 2 using Site Directed Mutagenesis. A vector was created as shown in 5.

Then, the vector substituted with the TILR sequence was amplified using the same primer set for amplifying the spike antigen in Table 1 as the plasmid #1 vector as a template, and then the pAdk35F vector cut with the restriction enzyme SwaI and infusion cloning ligation (in-fusion cloning ligation, Clontech, Cat. #: 639648) to construct an improved spike antigen expression vector, plasmid #2 vector (SEQ ID NO: 24). The portion encoding the spike protein in the plasmid #2 vector is shown in SEQ ID NO: 8, and the nucleotide sequence of the adenovirus into which the spike protein has been introduced is shown in SEQ ID NO: 25.

Sequence (5'→3') sequence number forward primer AGA CCA TCC TCA GGT CTG TGG CAA GCC AGA G 9 reverse primer CCT CCT ACC AGA CCC AGA CCA TCC TCA GGT 10

<2-2> Construction of an improved spike antigen expression vector (plasmid #3 vector; pAdCLD-CoV19 vector)

The cleavage recognition sequence (SEQ ID NO: 6, amino acid sequence: TNSPRRAR) of the spike antigen domains S1 and S2 of the pCMV3-SARS-CoV-2 (Spike ORF) vector used as a template for the polymerase chain reaction in Example 1 was site-directed. The pCMV3-SARS-CoV-2 (Spike GGGGS) vector was constructed by substituting the TGGGGSR linker sequence (SEQ ID NO: 11) using the primers shown in Table 3 using site directed mutagenesis. Then, the vector substituted with the TGGGGSR sequence was amplified using the same primer set for amplifying the spike antigen in Table 1 as the #1 vector as a template, and then the pAdk35F vector cut with the restriction enzyme SwaI and in-fusion cloning ligation (in-fusion cloning ligation, Clontech, Cat. #: 639648) to construct an improved spike antigen expression vector, plasmid #3 vector (pAdCLD-CoV19 vector) (SEQ ID NO: 26). In the plasmid #3 vector, the part encoding the spike protein is shown in SEQ ID NO: 12, and the nucleotide sequence of the adenovirus into which the spike protein has been introduced is shown in SEQ ID NO: 27.

Sequence (5'→3') sequence number forward primer CGG TGG CGG TGG GTC GAG GTC TGT GGC AAG CCA GAG 13 reverse primer GAC CCA CCG CCA CCG GTC TGG GTC TGG TAG GAG G 14

<2-3> Construction of an improved spike antigen expression vector (plasmid #4 vector)

The site-directed mutagenesis technique (amino acid sequence: TNSPRRAR) of the cleavage recognition sequence (amino acid sequence: TNSPRRAR) of domains S1 and S2 of the spike antigen of the pCMV3-SARS-CoV-2 (Spike ORF) vector used as a template for the polymerase chain reaction in Example 1 Site Directed Mutagenesis) was substituted with the TGGGGSGGGGSGGGGSR sequence (SEQ ID NO: 15) using the primers shown in Table 4 below (pCMV3-SARS-CoV-2 (Spike GGGGSx3)). Subsequently, the vector substituted with the TGGGGSGGGGSGGGGSR sequence was amplified using the same primer set for amplifying the spike antigen as the plasmid #1 vector as a template, and then the pAdk35F vector cut with the restriction enzyme SwaI and in-fusion cloning ligation (Clontech , Cat. #: 639648) to construct an improved spike antigen expression vector, plasmid #4 vector (SEQ ID NO: 28). In the plasmid #4 vector, the portion encoding the spike protein is shown in SEQ ID NO: 16, and the nucleotide sequence of the adenovirus into which the spike protein has been introduced is shown in SEQ ID NO: 29.

Sequence (5'→3') sequence number forward primer GGG CGG TGG TGG GTC GGG TGG CGG CGG TTC CAG GTC TGT GGC AAG CCA GAG 17 reverse primer GAC CCA CCA CCG CCC GAC CCA CCG CCA CCG GTC TGG GTC TGG TAG GAG G 18

< Example 3> spike antigen loading adenovirus Creation of vectors (#1 to #4 vectors)

Adenovirus vectors (#1 to #4 vectors) were produced using the HEK293R cell line from the vectors (plasmids #1 to #4) of Examples 1 and 2 above. Adenovirus was produced by transfecting 12.5 μg of each vector with 25 μl of Lipofectamine 2000 (ThermoFisher, Cat. #: 11668027) into HEK293R cell line approximately 80% confluent in T25 plates to produce initial adenoviral vectors. Each initially produced adenovirus was amplified by infecting 20 T175 flasks containing 4×10 ⁷ HEK293R cell lines.

Subsequently, the amplified adenovirus #1 to #4 vectors were first subjected to cesium chloride density gradient centrifugation (1.2 g/mL CsCl + 1.4 g/mL CsCl, 32,000 RPM, 90 minutes). and second (1.35 g/mL CsCl, 32,000 RPM, 18 hours), and finished adenovirus was produced through dialysis (20 mM Tris-HCl, 25 mM sodium chloride, 2.5% glycerol).

< Example 4> Comparison of antigen expression levels of antigen expression vectors in vitro

<4-1> Comparison of intracellular antigen expression following antigen expression vector injection

In order to compare intracellular antigen expression levels of the vectors #1 to #4 prepared in Example 3, the antigen expression level in the THP-1 cell line derived from mononuclear cells was measured by flow cytometry (FACS).

Specifically, flow cytometry was performed by dispensing THP-1 cells into 2.5 × 10 ⁵ cells in each well in a 96-well culture dish, inoculating the cells with each vector at a multiplicity of infection (MOI) of 10, and then inoculating the cells at 24 incubated for hours. Thereafter, the cells in each well were transferred to a 1.5 ml tube, and 500 μl of FACS buffer was added and centrifuged (5000 rpm, 3 minutes, 4° C.). After removing the supernatant, 50 μl of each viability indicator dye (eFluor™ 450, ebioscience, cat #: 65-0863-14) diluted 1:1000 was added, and surface staining was performed at 4° C. for 30 minutes.

For the detection of antigens expressed inside cells, the cell fixation/permeabilization concentrate (ebioscience, Cat. #: 00-5123-43) was added to the cell fixation/permeabilization diluent (ebioscience, Cat. #: 00-5223-56) at 1: Diluted by 4, each 100 μl was added, and cell fixation/permeabilization was performed at 4° C. for 30 minutes. Spike antigen staining was performed using a 1:2500 diluted solution (antibody concentration: 0.4 μg/ml) at 4° C. for 1 hour, followed by washing, and then a 1:100 diluted solution of the secondary antibody, APC Goat anti-mouse IgG antibody (Biolegend, Cat: 405308) (antibody concentration: 2 μg/ml). ml) for antigen staining (4°C, 30 minutes). After the staining reaction, 300 μl buffer per sample was added and the degree of antigen expression was measured using a flow cytometer (BD bioscience, LSRFORESSA).

As a result, as shown in FIG. 6, it was confirmed that the adenovirus #3 vector prepared in Example 3 had the highest antigen expression level, which is the ability to produce proteins.

<4-2> Comparison of extracellular antigen expression following antigen expression vector injection

In order to compare the extracellular antigen expression levels of vectors #1 to #4 prepared in Example 3, the expression levels of antigens in mononuclear cell-derived THP-1 and muscle cell-derived RD cell lines were measured by Western blot analysis.

Specifically, the western blot analysis method for measuring the expression level of the spike protein antigen exported out of cells is as follows. After dispensing THP-1 and RD cells to 5 × 10 ⁵ cells per well in a 6-well culture dish, the cells were inoculated with each vector at an MOI of 50 and cultured for 24 hours. Then, the culture medium was harvested by centrifugation, and then the culture medium was concentrated using Microcon (Millipore, 50,000 MWCO, Cat. #: UFC805024), and the cultured cells were RIPA buffer (ThermoFisher, Cat. #: 89901). was broken down into protein units. The total amount of protein in the concentrated culture medium was measured using a BCA protein assay kit (Thermo Fisher, Cat. #: 23225).

To identify spike proteins (trimers, approximately 250 kDa or greater) in concentrated culture medium samples, 60 μg/well of sample was used with BoltTM Bis-Tris 4-12% plus, gel (ThermoFisher, Cat. #: NW04120BOX). was electrophoresed at 180V.

The electrophoresed gel was transferred to a PVDF membrane for 10 minutes at 20V using the iBlot 2 Dry blotting system (Invitrogen, Cat. #: IB21001). Then, after reacting with Rabbit SARS-CoV-2 spike antibody (GeneTex, Cat. #: GTX135360) and Goat anti-Rabbit IgG H&L (HRP), respectively, ECL prime western blotting detection reagent (Amersham, Cat. #: RPN2232) was used to detect SARS. -The trimeric spike protein possessed by CoV-2 was detected.

As a result, as shown in FIG. 7 , it was confirmed that the adenovirus #3 vector prepared in Example 3 had the highest antigen expression level for producing and excreting proteins.

< Example 5> Comparison of antibody production in mice following antigen expression vector injection

<5-1> Comparison of antibody production in mice according to injection of antigen expression vectors #1 to #4

After injecting vectors #1 to #4 prepared in Example 3 into mice, the amount of antibody production was compared.

Specifically, the spike antigen expression vector (#1 vector to #4 vector) prepared in Example 3 was injected intramuscularly into 6-7 week-old BALB/c mice at 2×10 ⁸ IFU/mouse, 6 per group. . About 300 μl of blood samples were collected by orbital blood sampling at 2-3 weeks after administration. Thereafter, plasma was separated by centrifugation (8000 rpm, 10 minutes, 20° C.), and the amount of neutralizing antibodies present in the blood was measured by enzyme-linked immunosorbent assay (ELISA).

For enzyme-linked immunosorbent assay, spike protein (Acro Biosystems, Cat. #: SPN-C52H84) was dissolved in PBSN (PBS 1 L + Sodium Azide 0.01 g) in a 96-well plate, coated at 100 ng/well, and then coated for 16 hours. The reaction was refrigerated at 4°C. After 16 hours of coating the 96-well plate, the coated protein was removed, washed three times with PBS, and 150 μl of blocking buffer (PBSN+BSA 1%) was added to each well and reacted (37° C., 90 minutes). During the reaction time, plasma was diluted 6400-fold in dilution buffer (PBSN+0.1% BSA+0.05% Tween-20), and after the blocking reaction was finished, the plate was washed three times with PBS, and each diluted plasma sample was taken 50 μl each. It was put into the well and reacted (37°C, 3 hours). After the reaction, washing with PBS three times and secondary antibodies, GAM-IgG-HRP (southernbiotech, Cat. #: 1030-05) and GAM-IgM-HRP (southernbiotech, Cat. #: 1020-05), were added to the dilution buffer at 1000 50 μl of the diluted solution was added to each well and reacted (37° C., 2 hours). After removing the secondary antibody and washing with PBS 5 times, 50 μl of a color development reagent (TMB Peroxidase Substrate buffer, ROCKLAND, Cat. #: TMBE-1000) was added to develop the color for 15 minutes, and 50 μl of 0.25N HCl was added to stop the color development. , the samples were analyzed at a wavelength of 450 nm with a microreader.

As a result, as shown in FIG. 8, the adenovirus #3 vector prepared in Example 3 showed the highest amount of antibody production.

<5-2> Comparison of expression period of mouse antibody generation according to antigen expression vector injection

In addition, the adenoviruses (#1 to #3 vectors) prepared in Example 3 were intramuscularly injected into 8-week-old BALB/c mice at 1×10 ⁹ VP/Mouse or 2×10 ⁸ VP/Mouse, 6 per group. performed About 300 μl of blood samples were collected from the mice at 2 to 4 weeks after administration through orbital blood sampling. Thereafter, plasma was separated through centrifugation (8000 rpm, 10 minutes, 20° C.), and the amount of antigen-specific antibodies present in the blood was measured by enzyme-linked immunosorbent assay (ELISA) according to Example 5-1.

As a result, as shown in FIG. 9, the amount of antigen-specific antibody present in the blood of the adenovirus #3 vector prepared in Example 3 was maintained at a higher level than that of the #2 vector for 4 weeks or more.

< Example 6> Amount of antibody production in monkeys following antigen expression vector injection and liver toxicity comparison of

<6-1> Comparison of antibody production in monkeys following antigen expression vector injection

The amount of antibody production in monkeys following the injection of the adenovirus (#1 and #3 vectors) prepared in Example 3 was compared.

Specifically, the adenovirus #1 and #3 vectors prepared in Example 3 were intramuscularly injected into 6- to 7-week-old cynomolgus monkeys at 1×10 ¹¹ VP/Monkey, two per group. At 2 and 3 weeks after immunization, blood samples were collected through vein blood collection of monkeys, and the amount of antibody present in the blood was measured using enzyme-linked immunosorbent test ( ELISA) and Pseudovirus Neutralization Assay.

For the enzyme-linked immunosorbent assay, spike protein (Acro Biosystems, Cat. #: SPN-C52H84) was dissolved in PBSN in a 96-well plate, coated with 100 ng/well, and reacted in a refrigerator at 4° C. for 16 hours. After 16 hours of coating the 96-well plate, the coated protein was removed, washed three times with PBS, and 150 μl of blocking buffer was added to each well and reacted (37° C., 90 minutes). During the reaction time, plasma was diluted 1600-fold in the dilution buffer, and after the blocking reaction was finished, the plate was washed three times with PBS, and then 50 μl of the diluted plasma sample was added to each well and reacted (37° C., 3 hours). After the reaction, PBS was washed three times and the secondary antibody, Human total Ig-HRP (southernbiotech, Cat. #: 1010-05) was diluted 1000 times in dilution buffer, and 50 μl was added to each well and reacted (37 ° C, 2 hours). did After removing the secondary antibody and washing with PBS 5 times, 50 μl of a color development reagent (TMB Peroxidase Substrate buffer, ROCKLAND, Cat. #: TMBE-1000) was added to develop the color for 15 minutes, and 50 μl of 0.25 N HCl was added to stop the color development. After that, the sample was analyzed at a wavelength of 450 nm in a microreader.

In the pseudovirus neutralization assay, 1×10 ⁴ cells/well of HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was placed in each well of a 96-well plate and cultured for 10 hours (37° C., 5% CO ₂ ). At 2 and 3 weeks after immunization, plasma collected through venous blood collection from monkeys was diluted 100 to 6400 times 4 times, and 7 × 10 ⁵ TU/mL of pseudovirus (lentivirus expressing spike protein and luciferase) was added to 1 After time reaction (37°C), the HEK293T-hACE2 96-well plate was inoculated with 2 μg/well (200 μl) polybrene (Merck, Cat. #: TR-1003-G) and cultured for 2 days. . Subsequently, the presence or absence of neutralizing antibodies binding to the spike protein in plasma was confirmed by measuring the degree of expression of the luciferase protein in the HEK293T-hACE2 cell line infected with the pseudovirus. Cells cultured for 2 days were lysed with 25 μg cell lysis reagent (Promega, Cat. #: E153A) after washing with DPBS. The dissolved sample was transferred to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, Cat. #: E151A) was added, and a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, Cat. #: LB960, software: Mikro 2000 program) was used to measure and analyze the degree of light emission (detection indicator injection - 5 seconds mixing - 2 seconds delay - 10 seconds measurement).

As a result, as shown in FIG. 10, it was confirmed that the amount of antibody production was excellent when the #3 vector was injected, and the antibody titer was maintained even after 5 weeks after vector injection. In addition, as shown in FIG. 11 , it was confirmed that the neutralizing antibody concentration was high when the #3 vector was injected. These results suggest that a large amount of neutralizing antibodies start to be produced 2 weeks after vaccine administration, effectively blocking viral cell infection.

<6-2> Comparison of liver toxicity in monkeys following antigen expression vector injection

Due to the nature of adenoviruses, most of them migrate to the liver and may cause liver toxicity, and liver toxicity is fatal to the human body. Therefore, it is very important to prepare a vaccine that does not cause liver toxicity even when a high dose of virus particles are administered. Therefore, liver toxicity was compared in monkeys following the injection of the adenovirus (#1 and #3 vectors) prepared in Example 3 above.

Adenovirus #1 and #3 vectors prepared in Example 3 were intramuscularly injected into 6- to 7-week-old cynomolgus monkeys at 1×10 ¹¹ VP/Monkey, two per group. Blood was collected from all animals before administration (pre) and at intervals of 9, 22, and 36 days. All blood collection was performed in a fasting state (free drinking water), and about 3 ml of blood was collected from the femoral vein using a disposable syringe (3 ml, 23G, Korea Vaccine, KOR).

About 0.6 ml of blood collected for blood biochemical tests was dispensed into SSTTM tubes (Vacutainer®, BD, USA), centrifuged at 13,000 rpm for 5 minutes (5424R, Eppendorf, USA) to separate serum, and biochemical Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) items, which are liver toxicity levels, were measured using an analyzer (7180, HITACHI, JPN).

As a result, as shown in FIG. 12 , it was confirmed that monkeys using the #1 and #3 vectors using the same adenoviral vector platform did not show severe liver toxicity despite administration of high doses of virus particles.

< Example 7> Measurement of T cell reactivity when antigen expression vectors were injected into mice and monkeys

<7-1> Mouse splenocytes and peripheral blood mononuclear cell( PBMCs ) T cell reactivity measurement

T cell reactivity in mice following injection of the spike antigen expression vectors (#1 vector, #3 vector) prepared in Example 3 was measured as follows.

Specifically, mice administered with the vaccine (#1, #3 vectors) of Example 5 were sacrificed at 10 weeks of administration, blood was collected through orbital blood sampling, and the spleen was separated. Splenocytes were pulverized using a 70 μm cell strainer (BD Bioscience, Cat. #: 352350) to form single cells, and red blood cells were removed using ACK lysis buffer (Gibco, Cat. #: A1049201). Blood samples were isolated for peripheral blood mononuclear cells (PBMC) using density gradient centrifugation using Histopaque®-1077 (Sigma-Aldrich, Cat. #: 10771). The separated splenocytes and PBMC were suspended in RF10 culture medium (RPMI1640 + 10% FBS + 1% penicillin/streptomycin) at 2×10 ⁶ cells/ml after measuring the cell number.

Plates coated with mouse IFN-γ ELISPOT kit (CTL, Cat. #: MIFNgp-2M/10) were incubated with Peptivator SARS-CoV-2 Prot_S (Miltenyi Biotec, Cat. #: 130-126-701) in preheated RF10 culture medium. ) was added at a concentration of 50 μg/ml to fill wells by 100 μl and stored in a 37° C. CO ₂ incubator for 20 minutes (wells for each group were duplicated). Thereafter, 100 μl of the resuspended mouse splenocytes and the PBMC-containing culture medium were added to each well, and cultured in a CO ₂ incubator at 37°C. Anti-CD3 mAb (1 μg/ml, Biolegend, Cat. #: 100331) was added to positive control wells, and only RF10 was added to negative control wells without cells. After culturing for 24 hours, ELISPOT development was performed in the same manner as the manufacturer's protocol included in the Mouse IFN-γ ELISPOT kit. After color development, the plate was dried at room temperature for 24 hours by blocking light, and then analyzed using an Immunospot S6 micro analyzer (CTL). Results were converted into units of 1×10 ⁶ PBMC.

As a result, as shown in FIG. 13, when the #3 vector was injected into the mouse, the spleen cells and peripheral blood mononuclear cells (PBMC) of the mouse were compared to the T cells in the group not injected with the vector and the group injected with the #1 vector. It was confirmed that the reactivity was significantly increased. The above results suggest that the vaccine composition of the present invention can actively induce memory immune responses by T cells as well as antibody production when reinfected with SARS-CoV-2.

<7-2> Monkey In peripheral blood mononuclear cells (PBMC) Measurement of T cell responsiveness

T cell reactivity in monkeys following injection of the adenovirus (#1 vector, #3 vector) prepared in Example 3 was measured as follows.

A blood sample of 5 ml was collected from the monkeys administered with the vaccine (#3 vector) of Example 6 through venous blood sampling at the 4th week of administration. For blood samples, PBMC were separated using density gradient centrifugation using Histopaque®-1077 (Sigma-Aldrich, Cat. #: 10771), and remaining red blood cells were separated using ACK lysis buffer (Gibco, Cat. #: A1049201). and removed it. The isolated PBMCs were suspended in RF10 media (RPMI1640 + 10% FBS + 1% penicillin/streptomycin) at 2E+06 cells/ml after measuring the cell number.

Plates coated with Human IFN-γ ELISPOT kit (CTL, Cat. #: HIFNgp-2M/10) were incubated with Peptivator SARS-CoV-2 Prot_S (Miltenyi Biotec, Cat. #: 130-126-701) in pre-warmed RF10 culture medium. ) was added at a concentration of 100 μg/ml, and each well was filled with 100 μl and stored in a 37° C. CO ₂ incubator for 20 minutes (wells for each group were doubled). Thereafter, 100 µl of the suspended PBMC-containing culture medium was added to each well and cultured at 37°C in a CO ₂ incubator. (PMA (10ng/ml) and ionomycin (1μg/ml) were added to the positive control well, and RF10 was added to the negative control well without cells. After culturing for 24 hours, Human IFN-γ ELISPOT kit ELISPOT development was carried out in the same way as the included manufacturer's protocol. After color development, the plate was shaded and stored at room temperature for 24 hours. After the plate was dried, it was analyzed using the Immunospot S6 micro analyzer (CTL) to derive the result. It was converted into 1×10 ⁶ PBMC units.

As a result, as shown in FIG. 14 , when the #3 vector was injected into monkeys, it was confirmed that T cell reactivity was significantly increased in peripheral blood mononuclear cells (PBMC) compared to the group not injected with the vector. The above results suggest that the vaccine composition of the present invention can actively induce memory immune responses by T cells as well as antibody production when reinfected with SARS-CoV-2.

<Example 8> Comparison of antigen-specific neutralizing antibody production in mice and monkeys by injection of #3 antigen expression vector to #3 antigen heterozygous vector

<8-1> Comparison of antigen-specific neutralizing antibody production in mice following injection of #3 antigen expression vector and #3 antigen heterozygous vector

After injecting the #3 vector prepared in Example 3 and the #3 heterozygous vector (SEQ ID NO: 30) prepared as an equivalence comparison group into mice, the amount of antibody production was compared. Heterogeneous vector #3 is a form in which the E4 gene among the adenovirus genes of the #3 vector used in Example 3 is rearranged into the E1 region of the viral genome, and the Ad5/ In the 35 vector, 711 bp of E4orf6 was deleted, and a recombinant spike protein (a fusion protein in which SARS-CoV-2 S1 domain and S2 domain were connected by a GGGGS linker) and E4orf6 gene were inserted into the E1 deletion site in the forward direction. Construction method is the same as in Example 3.

Specifically, the spike antigen expression vectors (#3 vector and #3 heterozygous vector) were intramuscularly injected into 6- to 7-week-old BALB/c mice at 1×10 ⁹ VP/mouse, 5 mice per group. After administration, a blood sample of about 300 µl was collected by orbital blood sampling at 9 weeks from the mouse. Thereafter, plasma was separated through centrifugation (8000 rpm, 10 minutes, 20° C.), and the amount of neutralizing antibodies present in the blood was measured through a Pseudovirus Neutralization Assay.

In the pseudovirus neutralization assay, 1×10 ⁴ cells/well of HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was placed in each well of a 96-well plate and cultured for 10 hours (37° C., 5% CO ₂ ). Plasma collected through intravenous blood sampling of mice at 8 weeks after immunization was diluted 100 to 6400 times 4 times and reacted with 7 × 10 ⁵ TU / ㎖ pseudovirus (lentivirus expressing spike protein and luciferase) for 1 hour (37°C), and cultured in the HEK293T-hACE2 96-well plate in culture for 3 days. Subsequently, the presence or absence of neutralizing antibodies binding to the spike protein in plasma was confirmed by measuring the degree of expression of the luciferase protein in the HEK293T-hACE2 cell line infected with the pseudovirus. Cells cultured for 3 days were lysed with 25 μg cell lysis reagent (Promega, Cat. #: E153A) after washing with DPBS. The dissolved sample was transferred to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, Cat. #: E151A) was added, and a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, Cat. #: LB960, software: Mikro 2000 program) was used to measure and analyze the degree of light emission (detection indicator injection - 5 seconds mixing - 2 seconds delay - 10 seconds measurement).

As a result, as shown in FIG. 15, the #3 antigen vector and #3 antigen heterozygous vector showed excellent antibody yield, and there was no difference between the two groups. The above results suggest that #3 antigen has an equivalent level of neutralizing antibody activity even when loaded on different platform vectors.

<8-2> Comparison of antigen-specific neutralizing antibody production in monkeys following injection of #3 antigen expression vector and #3 antigen heterozygous vector

After injecting the #3 vector of Example 8-1 or the #3 heterozygous vector prepared from the equivalence comparison group into cynomolgus monkeys, the amount of antigen-specific neutralizing antibodies produced was compared.

Specifically, the spike antigen expression vectors (#3 vector and #3 heterozygous vector) were intramuscularly injected into 6- to 7-week-old monkeys at 2×10 ¹⁰ VP/Monkey, 2 per group. At 9 weeks after immunization, blood samples were collected through vein blood collection of monkeys, and the amount of antibodies present in the blood was analyzed using pseudovirus neutralization assay (Pseudovirus Neutralization Assay) using plasma from which blood cells were separated (8000 rpm, 10 minutes, 20 ° C). ) was measured through.

In the pseudovirus neutralization assay, 1×10 ⁴ cells/well of HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was placed in each well of a 96-well plate and cultured for 10 hours (37° C., 5% CO ₂ ). Plasma collected through vein blood collection of monkeys at 9 weeks after immunization was diluted 4-fold from 100 to 6400 times and reacted with 7×10 ⁵ TU/mL of pseudovirus (lentivirus expressing spike protein and luciferase) for 1 hour (37°C), and cultured in the HEK293T-hACE2 96-well plate in culture for 3 days. Subsequently, the presence or absence of neutralizing antibodies binding to the spike protein in plasma was confirmed by measuring the degree of expression of the luciferase protein in the HEK293T-hACE2 cell line infected with the pseudovirus. Cells cultured for 3 days were lysed with 25 μg cell lysis reagent (Promega, Cat. #: E153A) after washing with DPBS. The dissolved sample was transferred to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, Cat. #: E151A) was added, and a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, Cat. #: LB960, software: Mikro 2000 program) was used to measure and analyze the degree of light emission (detection indicator injection - 5 seconds mixing - 2 seconds delay - 10 seconds measurement).

As a result, as shown in FIG. 16, when the #3 vector and the #3 heterozygous vector were injected, both groups showed excellent antibody production and no difference in expression.

<Example 9> Comparison of antibody production in mice following injection of recombinant spike protein

<9-1> Comparison of antibody production in mice according to injection of recombinant spike protein

After injecting recombinant spike proteins (#2 recombinant protein and #3 recombinant protein) derived from vectors #1 to #3 prepared in Example 3 into mice, the amount of antibody production was compared.

Specifically, recombinant spike proteins derived from #1 to #3 vectors were injected into 6-7 week-old BALB/c mice, 6 mice per group. 10 μg of recombinant spike proteins #1 to #3 were diluted in 150 μl of PBS solution (pH 7.4) and administered by intramuscular injection. After administration, about 300 μl of blood samples were collected by orbital blood sampling at 2 to 4 weeks from mice, and plasma was separated through centrifugation (8000 rpm, 10 minutes, 20 ° C) to determine the amount of neutralizing antibodies present in the blood. It was measured through enzyme-linked immunosorbent assay (ELISA) and pseudovirus neutralization assay (Pseudovirus Neutralization Assay).

For enzyme-linked immunosorbent assay, spike protein (Acro Biosystems, Cat. #: SPN-C52H84) was dissolved in PBSN (PBS 1L + Sodium Azide 0.01g) in a 96-well plate, coated at 100 ng/well, and incubated for 4 hours for 16 hours. The reaction was refrigerated at °C. After 16 hours of coating the 96-well plate, the coating protein was removed, washed three times with PBS, and 150 μl of blocking buffer (PBSN+BSA 1%) was added to each well and reacted (37° C., 90 minutes), During the reaction time, plasma was diluted 6400-fold in dilution buffer (PBSN+0.1% BSA+0.05% Tween-20), and after the blocking reaction was finished, the plate was washed three times with PBS, and each diluted plasma sample was taken 50 μl each. It was put into the well and reacted (37°C, 3 hours). After the reaction, washing with PBS three times and secondary antibodies, GAM-IgG-HRP (southernbiotech, Cat. #: 1030-05) and GAM-IgM-HRP (southernbiotech, Cat. #: 1020-05), were added to the dilution buffer at 1000 50 μl of the diluted solution was added to each well and reacted (37° C., 2 hours). Then, after removing the secondary antibody and washing with PBS 5 times, 50 μl of a color development reagent (TMB Peroxidase Substrate buffer, ROCKLAND, Cat. #: TMBE-1000) was added to develop the color for 15 minutes, and 50 μl of 0.25N HCl was added to stop the color development. , the samples were analyzed at a wavelength of 450 nm with a microreader.

In the pseudovirus neutralization assay, 1×10 ⁴ cells/well of HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was placed in each well of a 96-well plate and cultured for 10 hours (37° C., 5% CO ₂ ). Plasma collected through intravenous blood sampling of mice at 2 to 4 weeks after immunization was diluted 100 to 6400 times (4 times) and mixed with pseudovirus (lentivirus expressing spike protein and luciferase) at 7×10 ⁵ TU/ml. After reacting together for 1 hour (37° C.), they were cultured for 3 days in a HEK293T-hACE2 96-well plate in culture. Subsequently, the presence or absence of neutralizing antibodies binding to the spike protein in plasma was confirmed by measuring the degree of expression of the luciferase protein in the HEK293T-hACE2 cell line infected with the pseudovirus. Cells cultured for 3 days were washed with DPBS and lysed with 25 μg cell lysis reagent (Promega, Cat. #: E53A), and then the lysed samples were transferred to an opaque 96-well plate and 100 μg luciferase detection indicator (Promega, Cat. #: E151A) and measure the level of luminescence using a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, Cat. #: LB960, software: Mikro 2000 program) (injection of detection indicator-5 seconds mixing-2 seconds delay- 10 seconds) and analyzed.

<Example 10> Comparison of antibody production in mice following spike antigen plasmid injection

<10-1> Comparison of mouse antibody production according to spike antigen plasmid injection

After injecting vectors #1 to #3 prepared in Examples 1 and 2 in the form of plasmids (plasmid #1 vector and plasmid #3 vector) into mice, the amount of antibody production was compared.

Specifically, plasmid #2 to plasmid #3 vectors prepared in Examples 1 and 2 were introduced into E. coli and cultured in 200 mL LB culture medium for one day. The cultured plasmids were harvested using the QIAGEN Endofree Plasmid Maxi kit (Cat.# 12362) and then administered to 6-7 week old BALB/c mice, 6 per group. 100 μg of vectors #2 to p#3 were diluted in 50 μl of PBS solution (pH 7.4) and administered by intramuscular injection. After administration, about 300 μl of blood samples were collected by orbital blood sampling at 2 to 4 weeks after administration, and plasma was separated through centrifugation (8000 rpm, 10 minutes, 20 ° C) to determine the amount of neutralizing antibodies present in the blood. It was measured through enzyme-linked immunosorbent assay (ELISA) and pseudovirus neutralization assay (Pseudovirus Neutralization Assay).

For enzyme-linked immunosorbent assay, spike protein (Acro Biosystems, Cat. #: SPN-C52H84) was dissolved in PBSN (PBS 1L + Sodium Azide 0.01 g) in a 96-well plate, coated at 100 ng/well, and incubated for 4 hours for 16 hours. The reaction was refrigerated at °C. After 16 hours of coating the 96-well plate, the coating protein was removed, washed three times with PBS, and 150 μl of blocking buffer (PBSN+BSA 1%) was added to each well and reacted (37° C., 90 minutes), During the reaction time, plasma was diluted 6400-fold in dilution buffer (PBSN+0.1% BSA+0.05% Tween-20), and after the blocking reaction was finished, the plate was washed three times with PBS, and each diluted plasma sample was taken 50 μl each. It was put into the well and reacted (37°C, 3 hours). After the reaction, washing with PBS three times and secondary antibodies, GAM-IgG-HRP (southernbiotech, Cat. #: 1030-05) and GAM-IgM-HRP (southernbiotech, Cat. #: 1020-05), were added to the dilution buffer at 1000 50 μl of the diluted solution was added to each well and reacted (37° C., 2 hours). Then, after removing the secondary antibody and washing with PBS 5 times, 50 μl of a color development reagent (TMB Peroxidase Substrate buffer, ROCKLAND, Cat. #: TMBE-1000) was added to develop the color for 15 minutes, and 50 μl of 0.25N HCl was added to stop the color development. , the samples were analyzed at a wavelength of 450 nm with a microreader.

In the pseudovirus neutralization assay, 1×10 ⁴ cells/well of HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was placed in each well of a 96-well plate and cultured for 10 hours (37° C., 5% CO ₂ ). Plasma collected through intravenous blood sampling of mice at 2 to 4 weeks after immunization was diluted 100 to 6400 times (4 times) and mixed with pseudovirus (lentivirus expressing spike protein and luciferase) at 7×10 ⁵ TU/ml. After reacting together for 1 hour (37° C.), they were cultured for 3 days in a HEK293T-hACE2 96-well plate in culture. Subsequently, the presence or absence of neutralizing antibodies binding to the spike protein in plasma was confirmed by measuring the degree of expression of the luciferase protein in the HEK293T-hACE2 cell line infected with the pseudovirus. Cells cultured for 3 days were lysed with 25 μg cell lysis reagent (Promega, Cat. #: E153A) after washing with DPBS. The dissolved sample was transferred to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, Cat. #: E151A) was added, and a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, Cat. #: LB960, software: Mikro 2000 program) was used to measure and analyze the degree of light emission (detection indicator injection - 5 seconds mixing - 2 seconds delay - 10 seconds measurement).

<110> Cellid Co.,Ltd. <120> A vector comprising polynucleotide encoding SARS-CoV2 recombinant spike protein and vaccine composition for preventing COVID-19 including the same <130> 2021P-08-021 <150> KR 10-2020-0108276 <151> 2020-08-27 <160> 30 <170> KoPatentIn 3.0 <210> 1 <211> 34030 <212> DNA <213> artificial sequence <220> <223> pAdk35F <400> 1 ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60 aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120 ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag 180 gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240 aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300 gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360 ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420 cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480 cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540 gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600 cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660 agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720 ctctgctgaa gccagttacc ttcgga aaaa gagttggtag ctcttgatcc ggcaaacaaa 780 ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840 gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900 cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960 attaaaaatg aagttttaaa tcaatctaaa gtatata tga gtaaacttgg tctgacagtt 1020 accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080 ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140 gtgctgcaat gataccgcga gacccac gct caccggctcc agatttatca gcaataaacc 1200 agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260 ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320 ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380 cgtagaaagc cagtccgcag aaacggtgct gaccccgg at gaatgtcagc tactgggcta 1440 tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500 ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560 cgccctctgg taaggttggg aagccctg ca aagtaaactg gatggctttc ttgccgccaa 1620 ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680 tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740 gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800 cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860 aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920 tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980 atctcctgtc atctcacctt gctcctgccg aga aagtatc catcatggct gatgcaatgc 2040 ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100 tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160 agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220 gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280 gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340 tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400 tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgcctt ctat cgccttcttg 2460 acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520 gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580 gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640 aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700 gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760 tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820 gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgc gctt 2880 aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940 atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000 tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060 atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120 tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180 aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240 gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 33 00 cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360 gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420 ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480 ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540 atgacggtaa atggcccgcc tggcattatg ccc agtacat gaccttatgg gactttccta 3600 cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660 acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg 3720 acgtcaatgg gagtttgttt tggca ccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780 actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca 3840 gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt cgacgagctc 3900 gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa 3960 gacaccggga ccgatccagc ctccgattta aattgatcat aatcag ccat accacatttg 4020 tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa 4080 tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca 4140 atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 4200 ccaaactcat caatgtatct taacgcggat ctgggcgtgg ttaagggtgg gaaagaatat cagcat tgat ggtcgccccg tcctgcccgc 4440 aaactctact accttgacct acgagaccgt gtctggaacg ccgttggaga ctgcagcctc 4500 cgccgccgct tcagccgctg cagccaccgc ccgcgggatt gtgactgact ttgctttcct 4560 gagcccgctt gcaagcagtg cagcttcccg ttcatccgcc cgcgatgaca agttgacggc 4620 tcttttggca caattggatt ctttgacccg ggaacttaat gtcgtttctc agcagctgtt 4680 ggatctgcgc cagcaggttt ctgccctgaa ggcttcctcc cctcccaatg cggtttaaaa 4740 cataaataaa aaaccagact ctgtttggat ttggatcaag caagtgtctt gctgtcttta 4800 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4860 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4920 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4980 gatgatccag tcgtagcagg ag cgctgggc gtggtgccta aaaatgtctt tcagtagcaa 5040 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 5100 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 5160 agccatatcc ctccggggat tcatgttgg cagaaccacc agcacagtgt atccggtgca 5220 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 5280 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 5340 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 5400 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcgg ta taatggttcc 5460 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 5520 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 5580 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 5640 aatcacacct attaccggct gcaactggta gttaagagag ctgcagctgc cgtcatccct 5700 gagcagg ggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5760 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5820 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5880 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5940 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 6000 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 6060 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 6120 at accgattc cggggagtag 6300 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 6360 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 6420 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 6480 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 6540 tctgagacaa agg ctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 6600 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 6660 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6720 gggctataa a agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6780 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6840 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6900 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6960 aacgacccgt agagggcgtt ggacagca cca accgcgg 7140 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 7200 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 7260 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 7320 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 7380 tatgggttga gtgggggacc ccatggcatg gggt gggtga gcgcggaggc gtacatgccg 7440 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 7500 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 7560 ggaccgaggt tgctacgg gc gggctgctct gctcggaaga ctatctgcct gaagatggca 7620 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 7680 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7740 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7800 cccttttttt tccacagctc gcggttgagg acaaactctt cg cggtcttt ccagtactct 7860 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7920 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7980 agcgaggtgt gggtgagcgc aa aggtgtcc ctgaccatga ctttgaggta ctggtatttg 8040 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 8100 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 8160 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 8220 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatg taaag ttccaagaag 8280 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 8340 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 8400 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 8460 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 8520 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 8580 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 8640 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 8700 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8760 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8820 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aagga agcag 8880 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8940 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 9000 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 9060 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 9120 ttta cctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 9180 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 9240 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 9300 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 9360 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 9420 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 9480 tgagcttgaa cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 9540 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 9600 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 9660 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9720 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9780 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9840 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9900 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9960 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 10020 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 10080 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 10140 ggcggcgacg ac ggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 10200 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 10260 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 10320 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 10380 ccgcatcgac cggatcggaa aacctctcga gaaaggcgt c taaccagtca cagtcgcaag 10440 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 10500 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 10560 ccatgtcctt gg gtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 10620 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 10680 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10740 gccgtaggg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10800 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ct gctgcacc tgcgtgaggg 10860 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10920 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10980 acctgagacg cgagtaagcc ct cgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 11040 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 11100 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 11160 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 11220 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gt caggcgcg 11280 cgcaatcgtt gacgctctag cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg 11340 tctggtggat aaattcgcaa gggtatcatg gcggacgacc ggggttcgag ccccgtatcc 11400 ggccgtccgc cgtgatccat gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc 11460 agacaacggg ggagtgctcc ttttggcttc cttccaggcg cggcggctgc tgcgctagct 11520 tttttggcca ctggccgcgc gcagcgtaag cggttaggct ggaaagcgaa agcattaagt 11580 ggctcgctcc ctgtagccgg agggttattt tccaagggtt gagtcgcggg acccccggtt 11640 cgagtctcgg accggccgga ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc 11700 ccgcttgcaa attcctccgg aaacagggac gagccccttt tttgcttttc ccagatgcat 11760 ccggtgctgc ggcagatgcg cccccctcct cagcagcggc aagagcaaga gcagcggcag 11820 acatgcaggg caccctcccc tcctcctacc gcgtcaggag gggc gacatc cgcggttgac 11880 gcggcagcag atggtgatta cgaacccccg cggcgccggg cccggcacta cctggacttg 11940 gaggagggcg agggcctggc gcggctagga gcgccctctc ctgagcggca cccaagggtg 12000 cagctgaagc gtgatacgcg tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc 12060 gagggagagg agcccgagga gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg 1212 0 catggcctga atcgcgagcg gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc 12180 gggattagtc ccgcgcgcgc acacgtggcg gccgccgacc tggtaaccgc atacgagcag 12240 acggtgaacc aggagattaa ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg 12300 gcgcgcgagg aggtggctat aggactgatg catctgtggg actttgtaag cgcgctggag 12360 caaaacccaa atagcaagcc gctcatggcg cagctgttcc ttatagtgca gcacagcagg 12420 gacaacgagg cattcaggga tgcgctgcta aacatagtag agcccgaggg ccgctggctg 12480 ctcgatttga taaacatcct gcagagcata gtggtgcagg agcgcagctt gagcctggct 12540 gacaaggtgg ccgccatcaa ctattc catg cttagcctgg gcaagtttta cgcccgcaag 12600 atataccata ccccttacgt tcccatagac aaggaggtaa agatcgaggg gttctacatg 12660 cgcatggcgc tgaaggtgct taccttgagc gacgacctgg gcgtttatcg caacgagcgc 12720 atccacaagg ccgtgagcgt gagccggcgg cgcgagctca gcgaccgcga gctgatgcac 12780 agcctgcaaa gggccctggc tggcacgggc agcggcgata gagaggccga gtcctacttt 12840 gacgcgggcg ctgacctgcg ctgggcccca agccgacgcg ccctggaggc agctggggcc 12900 ggacctgggc tggcggtggc acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat 12960 gacgaggacg atgagtac ga gccagaggac ggcgagtact aagcggtgat gtttctgatc 13020 agatgatgca agacgcaacg gacccggcgg tgcgggcggc gctgcagagc cagccgtccg 13080 gccttaactc cacggacgac tggcgccagg tcatggaccg catcatgtcg ctgactgcgc 13 140 gcaatcctga cgcgttccgg cagcagccgc aggccaaccg gctctccgca attctggaag 13200 cggtggtccc ggcgcgcgca aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc 13260 tggccgaaaa cagggccatc cggcccgacg aggccggcct ggtctacgac gcgctgcttc 13320 agcgcgtggc tcgttacaac agcggcaacg tgcagaccaa cctggaccgg ctggtggggg 13380 atgtgcgcga ggccgtggcg cagcgtga gc gcgcgcagca gcagggcaac ctgggctcca 13440 tggttgcact aaacgccttc ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg 13500 actacaccaa ctttgtgagc gcactgcggc taatggtgac tgagacaccg caaagtgagg 1356 0 tgtaccagtc tgggccagac tattttttcc agaccagtag acaaggcctg cagaccgtaa 13620 acctgagcca ggctttcaaa aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg 13680 accgcgcgac cgtgtctagc ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag 13740 cgcccttcac ggacagtggc agcgtgtccc gggacacata cctaggtcac ttgctgacac 13800 tgtaccgcga ggccataggt caggcgcatg tggacgagca tactttccag gagattacaa 13860 gtgtcagccg cgcgctgggg caggaggaca cgggcagcct ggaggcaacc ctaaactacc 13920 tgctgaccaa ccggcggcag aagatcccct cgttgcacag tttaaacagc gaggaggagc 13980 gcattttgcg ctacgtgcag cagagcgtga gccttaacct gatgcgcgac ggggtaacgc 14040 ccagcgtggc gctggacatg accgcgcgca acatggaacc gggcatgtat gcctcaaacc 14100 ggccgtttat caaccgccta atggactact tgcatcgcgc ggccgccgtg aaccccgagt 14160 atttcaccaa tgccatcttg aacccgcact ggctaccgcc ccctggtttc tacaccgggg 14220 gattcgaggt gcccgagggt aacgatggat tcctctggga cgacatagac gacagcgtgt 14280 tttccccgca accgcagacc ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc 14340 tgcgaaagga aagcttccgc aggccaagca gcttgtccga tctaggcgct gcggccccgc 14400 ggtcagatgc tagtagccca tttccaagct t gatagggtc tcttaccagc actcgcacca 14460 cccgcccgcg cctgctgggc gaggaggagt acctaaacaa ctcgctgctg cagccgcagc 14520 gcgaaaaaaa cctgcctccg gcatttccca acaacgggat agagagccta gtggacaaga 14580 tgagtagatg gaagacgtac gcgcaggagc acagggacgt gccaggcccg cgcccgccca 14640 cccgtcgtca aaggcacgac cgtcagcggg gtctggtgtg ggaggacgat gactcggcag 14700 acgaca gcag cgtcctggat ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca 14760 ggctggggag aatgttttaa aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg 14820 ccatggcacc gagcgttggt tttcttgtat tccccttagt atgc ggcgcg cggcgatgta 14880 tgaggaaggt cctcctccct cctacgagag tgtggtgagc gcggcgccag tggcggcggc 14940 gctgggttct cccttcgatg ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg 15000 gcctaccggg gggagaaaca gcatccgtta ctctgagttg gcacccctat tcgacaccac 15060 ccgtgtgtac ctggtggaca acaagtcaac ggatgtggca tccctgaact accagaacga 15120 ccacagcaac tttct gacca cggtcattca aaacaatgac tacagcccgg gggaggcaag 15180 cacacagacc atcaatcttg acgaccggtc gcactggggc ggcgacctga aaaccatcct 15240 gcataccaac atgccaaatg tgaacgagtt catgtttacc aataagttta aggcgcgggt 15300 gatggtgtcg cgcttgccta ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga 15360 gttcacgctg cccgagggca actactccga gaccatgacc atagacctta tgaacaacgc 15420 gatcgtggag cactacttga aagtgggcag acagaacggg gttctggaaa gcgacatcgg 15480 ggtaaagttt gacacccgca acttcagact ggggtttgac cccgtcactg gtcttgtcat 15540 gcctggggta tatacaaacg aagcctt cca tccagacatc attttgctgc caggatgcgg 15600 ggtggacttc acccacagcc gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt 15660 ccaggagggc tttaggatca cctacgatga tctggagggt ggtaacattc ccgcactgtt 15720 ggatgt ggac gcctaccagg cgagcttgaa agatgacacc gaacagggcg ggggtggcgc 15780 aggcggcagc aacagcagtg gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc 15840 aatgcagccg gtggaggaca tgaacgatca tgccattcgc ggcgacacct ttgccacacg 15900 ggctgaggag aagcgcgctg aggccgaagc agcggccgaa gctgccgccc ccgctgcgca 15960 acccgaggtc gagaagcctc agaagaaacc ggtgatcaaa cccctgacag aggacagcaa 16020 gaaacgcagt tacaacctaa taagcaatga cagcaccttc acccagtacc gcagctggta 16080 ccttgcatac aactacggcg accctcagac cggaatccgc tcatggaccc tgctttgcac 16140 tcct gacgta acctgcggct cggagcaggt ctactggtcg ttgccagaca tgatgcaaga 16200 ccccgtgacc ttccgctcca cgcgccagat cagcaacttt ccggtggtgg gcgccgagct 16260 gttgcccgtg cactccaaga gcttctacaa cgaccaggcc gtctactccc aactcatccg 16320 ccagtttacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 16380 cccgccagcc cccaccatca ccaccgtcag tgaaaacgtt c ctgctctca cagatcacgg 16440 gacgctaccg ctgcgcaaca gcatcggagg agtccagcga gtgaccatta ctgacgccag 16500 acgccgcacc tgcccctacg tttacaaggc cctgggcata gtctcgccgc gcgtcctatc 16560 gagccgcact ttttgagca a gcatgtccat ccttatatcg cccagcaata acacaggctg 16620 gggcctgcgc ttcccaagca agatgtttgg cggggccaag aagcgctccg accaacaccc 16680 agtgcgcgtg cgcgggcact accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg 16740 gcgcaccacc gtcgatgacg ccatcgacgc ggtggtggag gaggcgcgca actacacgcc 16800 cacgccgcca ccagtgtcca cagtggacgc ggccattca g accgtggtgc gcggagcccg 16860 gcgctatgct aaaatgaaga gacggcggag gcgcgtagca cgtcgccacc gccgccgacc 16920 cggcactgcc gcccaacgcg cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg 16980 acgggcggcc atgcgggcc g ctcgaaggct ggccgcgggt attgtcactg tgccccccag 17040 gtccaggcga cgagcggccg ccgcagcagc cgcggccatt agtgctatga ctcagggtcg 17100 caggggcaac gtgtattggg tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac 17160 ccgccccccg cgcaactaga ttgcaagaaa aaactactta gactcgtact gttgtatgta 17220 tccagcggcg gcggcgcgca acgaagctat gtccaagcgc aaaatca aag aagagatgct 17280 ccaggtcatc gcgccggaga tctatggccc cccgaagaag gaagagcagg attacaagcc 17340 ccgaaagcta aagcgggtca aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga 17400 ggtggaactg ctgcacgcta ccgcg cccag gcgacgggta cagtggaaag gtcgacgcgt 17460 aaaacgtgtt ttgcgacccg gcaccaccgt agtctttacg cccggtgagc gctccacccg 17520 cacctacaag cgcgtgtatg atgaggtgta cggcgacgag gacctgcttg agcaggccaa 17580 cgagcgcctc gggggagtttg cctacggaaa gcggcataag gacatgctgg cgttgccgct 17640 ggacgagggc aacccaacac ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc 1 7700 gcttgcaccg tccgaagaaa agcgcggcct aaagcgcgag tctggtgact tggcacccac 17760 cgtgcagctg atggtaccca agcgccagcg actggaagat gtcttggaaa aaatgaccgt 17820 ggaacctggg ctggagcccg aggtccgcgt gcggcc aatc aagcaggtgg cgccgggact 17880 gggcgtgcag accgtggacg ttcagatacc cactaccagt agcaccagta ttgccaccgc 17940 cacagagggc atggagacac aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt 18000 gcaggcggtc gctgcggccg cgtccaagac ctctacggag gtgcaaacgg acccgtggat 18060 gtttcgcgtt tcagcccccc ggcgcccgcg ccgttcgagg aagtacggcg ccgccagcgc 18 120 gctactgccc gaatatgccc tacatccttc cattgcgcct acccccggct atcgtggcta 18180 cacctaccgc cccagaagac gagcaactac ccgacgccga accaccactg gaacccgccg 18240 ccgccgtcgc cgtcgccagc ccgtgctggc cccgatttcc gtgcgcag gg tggctcgcga 18300 aggaggcagg accctggtgc tgccaacagc gcgctaccac cccagcatcg tttaaaagcc 18360 ggtctttgtg gttcttgcag atatggccct cacctgccgc ctccgtttcc cggtgccggg 18420 attccgagga agaatgcacc gtaggagggg catggccggc cacggcctga cgggcggcat 18480 gcgtcgtgcg caccaccggc ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct 18540 gcccctcctt attccact ga tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt 18600 ggccttgcag gcgcagagac actgattaaa aacaagttgc atgtgggaaaa atcaaaataa 18660 aaagtctgga ctctcacgct cgcttggtcc tgtaactatt ttgtagaatg gaagacatca 18720 actttgcgtc tctggccccg cgacacggct cgcgcccgtt catgggaaac tggcaagata 18780 tcggcaccag caatatgagc ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta 18840 aaaatttcgg ttccaccgtt aagaactatg gcagcaaggc ctggaacagc agcacaggcc 18900 agatgctgag ggataagttg aaagagcaaa atttccaaca aaaggtggta gatggcctgg 18960 cctctggcat tagcggggtg gtggacctgg cca accaggc agtgcaaaat aagattaaca 19020 gtaagcttga tccccgccct cccgtagagg agcctccacc ggccgtggag acagtgtctc 19080 cagaggggcg tggcgaaaag cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa 19140 tagacgagcc tccctcgtac gaggaggcac taaagcaagg cctgcccacc acccgtccca 19200 tcgcgcccat ggctaccgga gtgctgggcc agcacacacc cgtaacgctg gacctgcctc 19260 cccccgccga cacccagcag aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc 19320 gtcctagccg cgcgtccctg cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag 19380 ccagtggcaa ctggcaaagc acactgaaca gcatcgt ggg tctgggggtg caatccctga 19440 agcgccgacg atgcttctga tagctaacgt gtcgtatgtg tgtcatgtat gcgtccatgt 19500 cgccgccaga ggagctgctg agccgccgcg cgcccgcttt ccaagatggc taccccttcg 19560 atgatgccgc agtgg tctta catgcacatc tcgggccagg acgcctcgga gtacctgagc 19620 cccgggctgg tgcagtttgc ccgcgccacc gagacgtact tcagcctgaa taacaagttt 19680 agaaacccca cggtggcgcc tacgcacgac gtgaccacag accggtccca gcgtttgacg 19740 ctgcggttca tccctgtgga ccgtgaggat actgcgtact cgtacaaggc gcggttcacc 19800 ctagctgtgg gtgataaccg tgtgctggac atggcttcca cgtactttga cat ccgcggc 19860 gtgctggaca ggggccctac ttttaagccc tactctggca ctgcctacaa cgccctggct 19920 cccaagggtg ccccaaatcc ttgcgaatgg gatgaagctg ctactgctct tgaaataaac 19980 ctagaagaag aggacgatga caacgaagac gaagtagac g agcaagctga gcagcaaaaa 20040 actcacgtat ttgggcaggc gccttattct ggtataaata ttacaaagga gggtattcaa 20100 ataggtgtcg aaggtcaaac acctaaatat gccgataaaa catttcaacc tgaacctcaa 20160 ataggagaat ctcagtggta cgaaacagaa attaatcatg cagctgggag agtcctaaaa 20220 aagactaccc caatgaaacc atgttacggt tcatatgcaa aacccacaaa tgaaaatgga 2028 0 gggcaaggca ttcttgtaaa gcaacaaaat ggaaagctag aaagtcaagt ggaaatgcaa 20340 tttttctcaa ctactgaggc agccgcaggc aatggtgata acttgactcc taaagtggta 20400 ttgtacagtg aagatgtaga tatagaaacc ccagacactc atatttctta cat gcccact 20460 attaaggaag gtaactcacg agaactaatg ggccaacaat ctatgcccaa caggcctaat 20520 tacattgctt ttagggacaa tttattggt ctaatgtatt acaacagcac gggtaatatg 20580 ggtgttctgg cgggccaagc atcgcagttg aatgctgttg tagatttgca agacagaaac 20640 acagagcttt cataccagct tttgcttgat tccattggtg atagaaccag gtacttttct 20700 at gtggaatc aggctgttga cagctatgat ccagatgtta gaattattga aaatcatgga 20760 actgaagatg aacttccaaa ttactgcttt ccactgggag gtgtgattaa tacagagact 20820 cttaccaagg taaaacctaa aacaggtcag gaaaatggat gggaaaaaga tgctacagaa 20880 ttttcagata aaaatgaaat aagagttgga aataattttg ccatggaaat caatctaaat 20940 gccaacctgt ggagaaattt cctgtactcc aacatagcgc tgtatttgcc cgacaagcta 21000 aagtacagtc cttccaacgt aaaaatttct gataacccaa acacctacga ctacatgaac 21060 aagcgagtgg tggctcccgg gctagtggac tgctacatta accttggagc acgctggtcc 21120 cttgactata tggacaac gt caacccattt aaccaccacc gcaatgctgg cctgcgctac 21180 cgctcaatgt tgctgggcaa tggtcgctat gtgcccttcc acatccaggt gcctcagaag 21240 ttctttgcca ttaaaaacct ccttctcctg ccgggctcat acacctacga gtggaacttc 21 300 agggaaggatg ttaacatggt tctgcagagc tccctaggaa atgacctaag ggttgacgga 21360 gccagcatta agtttgatag catttgcctt tacgccacct tcttcccccat ggcccacaac 21420 accgcctcca cgcttgaggc catgcttaga aacgacacca acgaccagtc ctttaacgac 21480 tatctctccg ccgccaacat gctctaccct atacccgcca acgctaccaa cgtgcccata 21540 tccatcccct cccgcaactg ggcggctt tc cgcggctggg ccttcacgcg ccttaagact 21600 aaggaaaccc catcactggg ctcgggctac gacccttatt acacctactc tggctctata 21660 ccctacctag atggaacctt ttacctcaac cacaccttta agaaggtggc cattaccttt 21720 gactcttctg tcagctggcc tggcaatgac cgcctgctta cccccaacga gtttgaaatt 21780 aagcgctcag ttgacgggga gggttacaac gttgcccagt gtaacatgac caaagactgg 21840 ttcctggtac aaatgctagc taactataac attggctacc agggcttcta tatcccagag 21900 agctacaagg accgcatgta ctccttcttt agaaacttcc agcccatgag ccgtcaggtg 21960 gtggatgata ctaaatacaa ggactaccaa caggt gggca tcctacacca acacaacaac 22020 tctggatttg ttggctacct tgcccccacc atgcgcgaag gacaggccta ccctgctaac 22080 ttcccctatc cgcttatagg caagaccgca gttgacagca ttacccagaa aaagtttctt 22140 tgcgatcgca ccctttggcg catcccattc tccagtaact ttatgtccat gggcgcactc 22200 acagacctgg gccaaaacct tctctacgcc aactccgccc acgcgctaga catgactttt aagca acatc aacaacagct gccgccatgg 22440 gctccagtga gcaggaactg aaagccattg tcaaagatct tggttgtggg ccatattttt 22500 tgggcaccta tgacaagcgc tttccaggct ttgtttctcc acaacaagctc gcctgcgcca 22560 tagtcaatac ggcc ggtcgc gagactgggg gcgtacactg gatggccttt gcctggaacc 22620 cgcactcaaa aacatgctac ctctttgagc cctttggctt ttctgaccag cgactcaagc 22680 ctgg ccccaa actcccatgg 22860 atcacaaccc caccatgaac cttattaccg gggtacccaa ctccatgctc aacagtcccc 22920 aggtacagcc caccctgcgt cgcaaccagg aacagctcta cagcttcctg gagcgccact 22980 cgccctactt ccgcagccac agtgcgcaga ttaggagcg c cacttctttt tgtcacttga 23040 aaaacatgta aaaataatgt actagagaca ctttcaataa aggcaaatgc tttatttgt 23100 acactctcgg gtgattattt acccccaccc ttgccgtctg cgccgtttaa aaatcaaagg 23160 ggttctgccg cgcatcgcta tgcgccactg gcagggacac gttgcgatac tggtgtttag 23220 tgctccactt aaactcaggc acaaccatcc gcggcagctc ggtgaagttt tcactccaca 23280 ggctgcgcac catcaccaac gcgtttagca ggtcgggcgc cgatatcttg aagtcgcagt 23340 tggggcctcc gccctgcgcg cgcgagttgc gatacacagg gttgcagcac tggaacacta 23400 tcagcgccgg gtggtgcac g ctggccagca cgctcttgtc ggagatcaga tccgcgtcca 23460 ggtcctccgc gttgctcagg gcgaacggag tcaactttgg tagctgcctt cccaaaaagg 23520 gcgcgtgccc aggctttgag ttgcactcgc accgtagtgg catcaaaagg tgaccgtgcc 23580 cggtctgggc gttaggatac agcgcctgca taaaagcctt gatctgctta aaagccacct 23640 gagcctttgc gccttcagag aagaacatgc cgcaagactt gccggaaaac tgattggccg 23 700 gacaggccgc gtcgtgcacg cagcaccttg cgtcggtgtt ggagatctgc accacatttc 23760 ggccccacg gttcttcacg atcttggcct tgctagactg ctccttcagc gcgcgctgcc 23820 cgttttcgct cgtcacatcc atttcaatca cgtgctcc tt atttatcata atgcttccgt 23880 gtagacactt aagctcgcct tcgatctcag cgcagcggtg cagccacaac gcgcagcccg 23940 tgggctcgtg atgcttgtag gtcacctctg caaacgactg caggtacgcc tgcaggaatc 24000 gccccatcat cgtcacaaag gtcttgttgc tggtgaaggt cagctgcaac ccgcggtgct 24060 cctcgttcag ccaggtcttg catacggccg ccagagcttc cacttggtca ggcagtagtt 24120 tga agttcgc ctttagatcg ttatccacgt ggtacttgtc catcagcgcg cgcgcagcct 24180 ccatgccctt ctcccacgca gacacgatcg gcacactcag cgggttcatc accgtaattt 24240 cactttccgc ttcgctgggc tcttcctctt cctcttgcgt cc gcatacca cgcgccactg 24300 ggtcgtcttc attcagccgc cgcactgtgc gcttacctcc tttgccatgc ttgattagca 24360 ccggtgggtt gctgaaaccc accatttgta gcgccacacatc ttctctttct tcctcgctgt 24420 ccacgattac ctctggtgat ggcgggcgct cgggcttggg agaagggcgc ttctttttct 24480 tcttgggcgc aatggccaaa tccgccgccg aggtcgatgg ccgcgggctg ggtgtgcgcg 2 4540 gcaccagcgc gtcttgtgat gagtcttcct cgtcctcgga ctcgatacgc cgcctcatcc 24600 gcttttttgg gggcgcccgg ggaggcggcg gcgacgggga cggggacgac acgtcctcca 24660 tggttggggg acgtcgcgcc gcaccgcgtc cg cgctcggg ggtggtttcg cgctgctcct 24720 cttcccgact ggccatttcc ttctcctata ggcagaaaaa gatcatggag tcagtcgaga 24780 agaaggacag cctaaccgcc ccctctgagt tcgccacacac cgcctccacc gatgccgcca 24840 acgcgcctac caccttcccc gtcgaggcac ccccgcttga ggaggaggaa gtgattatcg 24900 agcaggaccc aggttttgta agcgaagacg acgaggaccg ctcagtacca acagaggata 24960 aaaagcaaga ccaggacaac gcagaggcaa acgag gaaca agtcgggcgg ggggacgaaa 25020 ggcatggcga ctacctagat gtgggagacg acgtgctgtt gaagcatctg cagcgccagt 25080 gcgccattat ctgcgacgcg ttgcaagagc gcagcgatgt gcccctcgcc atagcggatg 25140 tcagccttgc ctacgaacgc cacctattct caccgcgcgt accccccaaa cgccaagaaa 25200 acggcacatg cgagcccaac ccgcgcctca acttctaccc cgtatttgcc gtgccagagg agg gtcttgg acgcgacgag aagcgcgcgg 25440 caaacgctct gcaacaggaa aacagcgaaa atgaaagtca ctctggagtg ttggtggaac 25500 tcgagggtga caacgcgcgc ctagccgtac taaaacgcag catcgaggtc acccactttg 25560 cctacccgg c acttaaccta ccccccaagg tcatgagcac agtcatgagt gagctgatcg 25620 tgcgccgtgc gcagcccctg gagagggatg caaatttgca agaacaaaca gaggagggcc 25680 tacccgcagt tggcgacgag cagctagcgc gctggcttca aacgcgcgag cctgccgact 25740 tggaggagcg acgcaaacta atgatggccg cagtgctcgt taccgtggag cttgagtgca 25800 tgcagcggtt ctttgctgac ccggagatgc agcgcaag ct agaggaaaca ttgcactaca 25860 cctttcgaca gggctacgta cgccaggcct gcaagatctc caacgtggag ctctgcaacc 25920 tggtctccta ccttggaatt ttgcacgaaa accgccttgg gcaaaacgtg cttcattcca 25980 cgctcaaggg cgaggc gcgc cgcgactacg tccgcgactg cgtttactta tttctatgct 26040 acacctggca gacggccatg ggcgtttggc agcagtgctt ggaggagtgc aacctcaagg 26100 agctgcagaa actgctaaag caaaacttga aggacctatg gacggccttc aacgagcgct 26160 ccgtggccgc gcacctggcg gacatcattt tccccgaacg cctgcttaaa accctgcaac 26220 agggtctgcc agacttcacc agtcaaagca tgttgcagaa ctttaggaac tttatcctag 26280 agcgctcagg aatcttgccc gccacctgct gtgcacttcc tagcgacttt gtgcccatta 26340 agtaccgcga atgccctccg ccgctttggg gccactgcta ccttctgcag ctagccaact 26400 accttgccta ccactctgac ataatggaag acgtgagcgg tg acggtcta ctggagtgtc 26460 actgtcgctg caacctatgc accccgcacc gctccctggt ttgcaattcg cagctgctta 26520 acgaaagtca aattatcggt acctttgagc tgcagggtcc ctcgcctgac gaaaagtccg 26580 cggctccggg gttgaaactc actccggggc tgtggacgtc ggcttacctt cgcaaatttg 26640 tacctgagga ctaccacgcc cacgagatta ggttctacga agaccaatcc cgcccgccta 267 00 atgcggagct taccgcctgc gtcattaccc agggccacat tcttggccaa ttgcaagcca 26760 tcaacaaagc ccgccaagag tttctgctac gaaagggacg gggggtttac ttggaccccc 26820 agtccggcga ggagctcaac ccaatccccc cgccgccgca g ccctatcag cagcagccgc 26880 gggcccttgc ttcccaggat ggcacccaaa aagaagctgc agctgccgcc gccacccacg 26940 gacgaggagg aatactggga cagtcaggca gaggaggttt tggacgagga ggaggaggac 27000 atgatggaag actgggagag cctagacgag gaagcttccg aggtcgaaga ggtgtcagac 27060 gaaacaccgt caccctcggt cgcattcccc tcgccggcgc cccagaaatc ggcaaccggt 27120 tccagcatgg ctacaacctc cgctcctcag gcgccgccgg cactgcccgt tcgccgaccc 27180 aaccgtagat gggacaccac tggaaccagg gccggtaagt ccaagcagcc gccgccgtta 27240 gcccaagagc aacaacagcg ccaaggctac cgctcatggc gcgggcacaa gaacgccata 27300 gttgcttgct tgcaagactg tgggggcaac atctccttcg cccgccgctt tcttctctac 27360 catcacggcg tggccttccc ccgtaacatc ctgcattact accgtcat ct ctacagccca 27420 tactgcaccg gcggcagcgg cagcaacagc agcggccaca cagaagcaaa ggcgaccgga 27480 tagcaagact ctgacaaagc ccaagaaatc cacagcggcg gcagcagcag gaggaggagc 27540 gctgcgtctg gcgcccaacg aacccgtatc gac ccgcgag cttagaaaca ggatttttcc 27600 cactctgtat gctatatttc aacagagcag gggccaagaa caagagctga aaataaaaaa 27660 caggtctctg cgatccctca cccgcagctg cctgtatcac aaaagcgaag atcagcttcg 27720 gcgcacgctg gaagacgcgg aggctctctt cagtaaatac tgcgcgctga ctcttaagga 27780 ctagtttcgc gccctttctc aaatttaagc gcgaaaacta cgtcatctcc ag cggccaca 27840 cccggcgcca gcacctgttg tcagcgccat tatgagcaag gaaattccca cgccctacat 27900 gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact actcaacccg 27960 aataaactac atgagcgcgg gaccccacat gatatcccgg gt caacggaa tacgcgccca 28020 ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta ataaccttaa 28080 tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca ccactgtggt 28140 acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc agcttgcggg 28200 cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga caatcagagg 28260 g cgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc gtccggacgg 28320 gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg caatcctaac 28380 tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactct gc aatttattga 28440 ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc actatccgga 28500 tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg actgaatgtt 28560 aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc gccacaagtg 28620 ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc atatcgaggg 28680 cccggc gcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc tgattcggga 28740 gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc tcactgtgat 28800 ttgcaactgt cctaaccctg gattacatca agatcctcta gttaatgtca ggtcg cctaa 28860 gtcgattaac tagagtaccc ggggatctta ttccctttaa ctaataaaaa aaaataataa 28920 agcatcactt acttaaaatc agttagcaaa tttctgtcca gtttattcag cagcacctcc 28980 ttgccctcct cccagctctg gtattgcagc ttcctcctgg ctgcaaactt tctccacaat 29040 ctaaatggaa tgtcagtttc ctcctgttcc tgtccatccg cacccactat cttcatgttg 29100 ttgcagatga agcgcgcaag accgtctgaa gataccttca accccgtgta tccatatgac 29160 acggaaaccg gtcctccaac tgtgcctttt cttactcctc cctttgtatc ccccaatggg 29220 tttcaagaga gtccccctgg ggtactctct ttgcgcctat ccgaacctct agtta cctcc 29280 aatggcatgc ttgcgctcaa aatgggcaac ggcctctctc tggacgaggc cggcaacctt 29340 acctcccaaa atgtaaccac tgtgagccca cctctcaaaa aaaccaagtc c ccctcacag tgtcagaagg aaagctagcc 29580 ctgcaaacat caggccccct caccaccacc gatagcagta cccttactat cactgcctca 29640 ccccctctaa ctactgccac tggtagcttg ggcattgact tgaaagagcc catttataca 29700 caaaatggaa aactaggact aaagtacggg gctcctttgc atgtaacaga cgacctaaac 29760 actttgaccg tagcaactgg tccaggtggg actattaata atacttcctt gcaaactaaa 29820 gttaactggag ccttgggttt tgattcacaa ggcaatatgc aacttaatgt agcaggagga 29880 ctaaggattg attctcaaaa cagacgcctt atacttgatg ttagttatcc gtttgatgct 29940 caaaaccaac taaatctaag actaggacag ggccctcttt tta taaactc agcccacaac 30000 ttggatatta actacaacaa aggcctttac ttgtttacag cttcaaacaa ttccaaaaag 30060 cttgaggtta acctaagcac tgccaagggg ttgatgtttg acgctacagc catagccatt 30120 aatgcaggag atgggcttga atttggtt ca cctaatgcac caaacacaaa tcccctcaaa 30180 acaaaaattg gccatggcct agaatttgat tcaaacaagg ctatggttcc taaactagga 30240 actggcctta gttttgacag cacaggtgcc attacagtag gaaacaaaaa taatgataag 30300 ctaactttgt ggaccggaat aaaccctcca cctaactgtc aaattgtgga aaacactaat 30360 acaaatgatg gcaaacttac tttagtatta gtaaaaaaatg gagggcttgt taatggct ac 30420 gtgtctctag ttggtgtatc agacactgtg aaccaaatgt tcacacaaaa gacagcaaac 30480 atccaattaa gattatattt tgactcttct ggaaatctat taactgagga atcagactta 30540 aaaattccac ttaaaaataa atcttctaca gcgaccagtg aaactgtag c cagcagcaaa 30600 gcctttatgc caagtactac agcttatccc ttcaacacca ctactaggga tagtgaaaac 30660 tacattcatg gaatatgtta ctacatgact agttatgata gaagtctatt tcccttgaac 30720 atttctataa tgctaaacag ccgtatgatt tcttccaatg ttgcctatgc catacaattt 30780 gaatggaatc taaatgcaag tgaatctcca gaaagcaaca tagctacgct gaccacatcc 30 840 ccctttttct tttcttacat tacagaagac gacaactaaa gaatcgtttg tgttatgttt 30900 caacgtgttt atttttcaat tgcagaaaat ttcaagtcat ttttcattca gtagtatagc 30960 cccaccacca catagcttat acagatcacc gtaccttaat caa actcaca gaaccctagt 31020 attcaacctg ccacctccct cccaacacac agagtacaca gtcctttctc cccggctggc 31080 cttaaaaagc atcatatcat gggtaacaga catattctta ggtgttatat tccacacggt 31140 ttcctgtcga gccaaacgct catcagtgat attaataaac tccccgggca gctcacttaa 31200 gttcatgtcg ctgtccagct gctgagccac aggctgctgt ccaacttgcg gttgcttaac 31260 gggcgg cgaa ggagaagtcc acgcctacat gggggtagag tcataatcgt gcatcaggat 31320 agggcggtgg tgctgcagca gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca 31380 ggaatacaac atggcagtgg tctcctcagc gatgattcgc accgcccgca gcataaggcg 31440 ccttgtcctc cgggcacagc agcgcaccct gatctcactt aaatcagcac agtaactgca 31500 gcacagcacc acaatattgt tcaaaatccc acagtgcaag gcgctgtatc caaagctcat 31560 ggcggggacc acagaaccca cgtggccatc ataccacaag cgcaggtaga ttaagtggcg 31620 acccctcata aacacgctgg acataaacat tacctctttt ggcatgttgt aattcaccac 31680 ctcccggtac catataaacc tctga ttaaa catggcgcca tccaccacca tcctaaacca 31740 gctggccaaa acctgcccgc cggctataca ctgcagggaa ccgggactgg aacaatgaca 31800 gtggagagcc caggactcgt aaccatggat catcatgctc gtcatgatat caatgttggc 31860 acaacacagg cacacggg ca tacacttcct caggattaca agctcctccc gcgttagaac 31920 catatcccag ggaacaaccc attcctgaat cagcgtaaat cccacactgc agggaagacc 31980 tcgcacgtaa ctcacgttgt gcattgtcaa agtgttacat tcgggcagca gcggatgatc 32040 ctccagtatg gtagcgcggg tttctgtctc aaaaggaggt agacgatccc tactgtacgg 32100 agtgcgccga gaca accgag atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga 32160 cgtagtcata tttcctgaag caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc 32220 ggtctcgccg cttagatcgc tctgtgtagt agttgtagta tatccactct ctcaa agcat 32280 ccaggcgccc cctggcttcg ggttctatgt aaactccttc atgcgccgct gccctgataa 32340 catccaccac cgcagaataa gccacaccca gccaacctac acattcgttc tgcgagtcac 32400 acacgggagg agcgggaaga gctggaagaa ccatgttttt tttttttc caaaagatta 32460 tccaaaacct caaaatgaag atctattaag tgaacgcgct cccctccggt ggcgtggtca 32520 aactctacag ccaaaga gataatggca tttgtaagat gttgcacaat ggcttccaaa 32580 aggcaaacgg ccctcacgtc caagtggacg taaaggctaa acccttcagg gtgaatctcc 32640 tctataaaca ttccagcacc ttcaaccatg cccaaataat tctcatctcg ccaccttctc 32700 aatatatct c taagcaaatc ccgaatatta agtccggcca ttgtaaaaat ctgctccaga 32760 gcgccctcca ccttcagcct caagcagcga atcatgattg caaaaattca ggttcctcac 32820 agacctgtat aagattcaaa agcggaacat taacaaaaat accgcgatcc cgtaggtccc 32880 ttcgcagggc cagctgaaca taatcgtgca ggtctgcacg gaccagcgcg gccacttccc 32940 cgccaggaac catgacaaaa gaacccacac tgattatgac acgcatactc ggagctatgc 33000 taaccagcgt agccccgatg taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc 33060 tgctcaaaaa atcaggcaaa gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat 33120 gcagataaag gcaggtaag c tccggaacca ccacagaaaa agacaccatt tttctctcaa 33180 acatgtctgc gggtttctgc ataaacacaa aataaaataa caaaaaaaca tttaaacatt 33240 agaagcctgt cttacaacag gaaaaacaac ccttataagc ataagacgga ctacggccat 33300 gccggcgtga ccgtaaaaaa actggtcacc gtgattaaaa agcaccaccg acagctcctc 33360 ggtcatgtcc ggaggtcataa tgtaagactc ggtaaacaca tcaggttgat t cacatcggt 33420 cagtgctaaa aagcgaccga aatagcccgg gggaatacat acccgcaggc gtagagacaa 33480 cattacagcc cccataggag gtataacaaa attaatagga gagaaaaaca cataaacacc 33540 tgaaaaaccc tcctgcctag gcaaaatagc accctcccgc tccaga acaa catacagcgc 33600 ttccacagcg gcagccataa cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa 33660 acaccactcg acacggcacc agctcaatca gtcacagtgt aaaaaagggc caagtgcaga 33720 gcgagtatat ataggactaa aaaatgacgt aacggttaaa gtccacaaaa aacacccaga 33780 aaaccgcacg cgaacctacg cccagaaacg aaagccaaaa aacccacaac ttcctcaaat aat ccaaaat aaggtatatt 34020attgatgatg 34030 <210> 2 <211> 9858 <212> DNA <213> artificial sequence <220> <223> pCMV3-SARS-CoV2 (Spike ORF) <400> 2 gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg 60 ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg 120 cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc 180 ttagggttag gcgttttgcg ctgcttcgcg agtacattta tattggctca tgtccaatat 240 gaccgccatg ttgacattga ttatgacta gttattaata gtaatcaatt acggggtcat 300 tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg 360 gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa 420 cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact 480 tggcagtaca tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta 540 aatggcccgc ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt 600 acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg 660 ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg 720 ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaat aaccccgccc 780 cgttgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt 840 tagtgaaccg tcagatcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 900 gctcgcggtt gaggacaaac tcttcgcggt ctttccagta ctcttggatc ggaaacccgt 960 cggcctccga acggtactcc gccaccgagg gacctgagcg agtccgcatc gaccggatcg 1020 gaaaacctct cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct gagcaccgtg 1080 gcgggcggca gcgggtggcg gtcggggttg tttctggcgg aggtgctgct gatgatgtaa 1140 ttaaagtagg cggtcttgag acggcggatg gtcgaggtga ggtgtggcag gcttgagatc 1200 cagctgttgg ggtgagtact ccctctcaaa agcgggcatt acttctgcgc taagattgtc 1260 agtttccaaa aacgaggagg atttgatatt cacctggccc gatctggcca tacacttgag 1320 tgacaatgac atccactttg cctttctctc cacaggtgtc cactcccagg tccaagttta 1380 aactttaata cgactcacta taggggccgc caccaagctt ggtaccatgt ttgtgttcct 1440 ggtgctgctg ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc 1500 tcctgcctac accaactcct tcaccagggg agtctactac cctgacaagg tgttcaggtc 1560 ctctgtgctg cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt 1620 ccatgccatc catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc 1680 attcaatgat ggagtctact ttgccagcac agagaagagc aacatcatca ggggctggat 1740 ttttggcacc accctggaca gcaagaccca gtccctgctg attgtgaaca atgccaccaa 1800 tgtggtgatt aaggtgtgtg agttccagtt ctgtaatgac ccattcctgg gagtctacta 1860 ccacaagaac aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa 1920 ctgtaccttt gaatatgtga gccaaccatt cctgatggac ttggagggca agcagggcaa 1980 cttcaagaac ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag 2040 caaacacaca ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc 2100 actggtggac ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca 2160 caggtcctac ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta 2220 ctatgtgggc tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat 2280 cacagatgct gtggactgtg ccctggaccc actgtctgag accaagtgta ccctgaaatc 2340 cttcacagtg gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag 2400 cattgtgagg tttccaaaca tcaccaacct gtgtccattt ggagaggtgt tcaatgccac 2460 caggtttgcc tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta 2520 ctctgtgctc tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac 2580 caaactgaat gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga 2640 tgaggtgaga cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact 2700 gcctgatgac ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt 2760 gggaggcaac tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga 2820 gagggacatc agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg 2880 cttcaactgt tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta 2940 ccaaccatac agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgtg 3000 tggaccaaag aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg 3060 actgacaggc acaggagtgc tgacagagag caacaagaag ttcctgccat tccaacagtt 3120 tggcagggac attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct 3180 gggacatcaca ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag 3240 caaccaggtg gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca 3300 tgctgaccaa cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac 3360 cagggctggc tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc 3420 aattggagca ggcatctggg cctcctacca gacccagacc atcctcaggt ctgtggcaag 3480 ccagagcatc attgcctaca caatgagtct gggagcagag aactctgtgg cttacagcaa 3540 caacagcatt gccatcccaa ccaacttcac catctctgtg accacagaga ttctgcctgt 3600 gagtatgacc aagacctctg tggactgtac aatgtatatc tgtggagaca gcacagagtg 3660 tagcaacctg ctgctccaat atggctcctt ctgtacccaa cttaacaggg ctctgacagg 3720 cattgctgtg gaacaggaca agaacaccca ggaggtgttt gcccaggtga agcagattta 3780 caagacacct ccaatcaagg actttggagg cttcaacttc agccagattc tgcctgaccc 3840 aagcaagcca agcaagaggt ccttcattga ggacctgctg ttcaacaagg tgaccctggc 3900 tgatgctggc ttcatcaagc aatatggaga ctgtctggga gacattgctg ccagggacct 3960 gatttgtgcc cagaagttca atggactgac agtgctgcct ccactgctga cagatgagat 4020 gattgcccaa tacacctctg ccctgctggc tggcaccatc acctctggct ggacctttgg 4080 agcaggagca gccctccaaa tcccatttgc tatgcagatg gcttacaggt tcaatggcat 4140 tggagtgacc cagaatgtgc tctatgagaa ccagaaactg attgccaacc agttcaactc 4200 tgccattggc aagattcagg actccctgtc cagcacagcc tctgccctgg gcaaactcca 4260 agatgtggtg aaccagaatg cccaggctct gaacaccctg gtgaagcaac tttccagcaa 4320 ctttggagcc atctcctctg tgctgaatga catcctgagc agactggaca aggtggaggc 4380 tgaggtccag attgacagac tgattacagg cagactccaa tccctccaaa cctatgtgac 4440 ccaacaactt atcagggctg ctgagattag ggcatctgcc aacctggctg ccaccaagat 4500 gagtgagtgt gtgctgggac aaagcaagag ggtggacttc tgtggcaagg gctaccacct 4560 gatgagtttt ccacagtctg cccctcatgg agtggtgttc ctgcatgtga cctatggtgcc 4620 tgcccaggag aagaacttca ccacagcccc tgccatctgc catgatggca aggctcactt 4680 tccaagggag ggaggtgtttg tgagcaatgg cacccactgg tttgtgaccc agaggaactt 4740 ctatgaacca cagattatca ccacagacaa cacctttgtg tctggcaact gtgatgtggt 4800 gattggcatt gtgaacaaca cagtctatga cccactccaa cctgaactgg actccttcaa 4860 ggaggaactg gacaaatact tcaagaacca caccagccct gatgtggacc tgggagacat 4920 ctctggcatc aatgcctctg tggtgaacat ccagaaggag attgacagac tgaatgaggt 4980 ggctaagaac ctgaatgagt ccctgattga ccctccaagaa ctgggcaaat atgaacaata 5040 catcaagtgg ccatggtaca tctggctggg cttcattgct ggactgattg ccattgtgat 5100 ggtgaccata atgctgtgtt gtatgacctc ctgttgttcc tgtctgaaag gctgttgttc 5160 ctgtggctcc tgttgtaagt ttgatgagga tgactctgaa cctgtgctga aaggagtgaa 5220 actgcactac acctgatcta gagcggccgc cgaattcggg cccgtttaaa cccgctgatc 5280 agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc 5340 cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc 5400 gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg 5460 ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga 5520 ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt 5580 aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc 5640 gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca 5700 agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc 5760 caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt 5820 tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac 5880 aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc 5940 ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat 6000 gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc 6060 atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga 6120 agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc 6180 atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt 6240 tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga 6300 ggcttttttg gaggcctagg cttttgcaaa aagctcccgg gagcttgtat atccattttc 6360 ggatctgatc agcacgtgat gaaaaagcct gaactcaccg cgacgtctgt cgagaagttt 6420 ctgatcgaaa agttcgacag cgtctccgac ctgatgcagc tctcggaggg cgaagaatct 6480 cgtgctttca gcttcgatgt aggagggcgt ggatatgtcc tgcgggtaaa tagctgcgcc 6540 gatggtttct acaaagatcg ttatgtttat cggcactttg catcggccgc gctcccgatt 6600 ccggaagtgc ttgacattgg ggaattcagc gagagcctga cctattgcat ctcccgccgt 6660 gcacagggtg tcacgttgca agacctgcct gaaaccgaac tgcccgctgt tctgcagccg 6720 gtcgcggagg ccatggatgc gatcgctgcg gccgatctta gccagacgag cgggttcggc 6780 ccattcggac cgcaaggaat cggtcaatac actacatggc gtgatttcat atgcgcgatt 6840 gctgatcccc atgtgtatca ctggcaaact gtgatggacg acaccgtcag tgcgtccgtc 6900 gcgcaggctc tcgatgagct gatgctttgg gccgaggact gccccgaagt ccggcacctc 6960 gtgcacgcgg atttcggctc caacaatgtc ctgacggaca atggccgcat aacagcggtc 7020 attgactgga gcgaggcgat gttcggggat tcccaatacg aggtcgccaa catcttcttc 7080 tggaggccgt ggttggcttg tatggagcag cagacgcgct acttcgagcg gaggcatccg 7140 gagcttgcag gatcgccgcg gctccgggcg tatatgctcc gcattggtct tgaccaactc 7200 tatcagagct tggttgacgg caatttcgat gatgcagctt gggcgcaggg tcgatgcgac 7260 gcaatcgtcc gatccggagc cgggactgtc gggcgtacac aaatcgcccg cagaagcgcg 7320 gccgtctgga ccgatggctg tgtagaagta ctcgccgata gtggaaaccg acgccccagc 7380 actcgtccga gggcaaagga atagcacgtg ctacgagatt tcgattccac cgccgccttc 7440 tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc 7500 ggggatctca tgctggagtt cttcgcccac cccaacttgt ttatgcagc ttataatggt 7560 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 7620 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc gtcgacctct 7680 agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc 7740 acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga 7800 gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg 7860 tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg 7920 cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg 7980 gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga 8040 aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg 8100 gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag 8160 aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc 8220 gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg 8280 ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt 8340 cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc 8400 ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc 8460 actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg 8520 tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca 8580 gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc 8640 ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct 8700 ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg 8760 gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt 8820 aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt 8880 gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc 8940 gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg 9000 cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc 9060 gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg 9120 gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca 9180 ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga 9240 tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct 9300 ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg 9360 cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca 9420 accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata 9480 cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct 9540 tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact 9600 cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa 9660 acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc 9720 atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga 9780 tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga 9840 aaagtgccac ctgacgtc 9858 <210> 3 <211> 3642 <212> DNA <213> artificial sequence <220> <223> spike protein coding sequence in #1 vector <400> 3 atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc 60 aggacccaac ttcctcctgc ctacaccaac tccttcacca gggggagtcta ctaccctgac 120 aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc 180 aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac 240 aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc 300 atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg 360 aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc 420 ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac 480 tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag 540 ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac 600 ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acagggcttc 660 tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc 720 ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca 780 ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat 840 gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag 900 tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc 960 caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag 1020 gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac 1080 tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat 1140 ggaggtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt 1200 gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac 1260 tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac 1320 ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac 1380 ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt 1440 aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc 1500 aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc 1560 cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac 1620 ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg 1680 ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag 1740 accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct 1800 ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg 1860 cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc 1920 aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat 1980 gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaccca gaccaacagc 2040 ccaaggaggg caaggtctgt ggcaagccag agcatcattg cctacacaat gagtctggga 2100 gcagagaact ctgtggctta cagcaacaac agcattgcca tcccaaccaa cttcaccatc 2160 tctgtgacca cagagattct gcctgtgagt atgaccaaga cctctgtgga ctgtacaatg 2220 tatatctgtg gagacagcac agagtgtagc aacctgctgc tccaatatgg ctccttctgt 2280 acccaactta acagggctct gacaggcatt gctgtggaac aggacaagaa cacccaggag 2340 gtgtttgccc aggtgaagca gatttacaag acacctccaa tcaaggactt tggaggcttc 2400 aacttcagcc agattctgcc tgacccaagc aagccaagca agaggtcctt cattgaggac 2460 ctgctgttca acaaggtgac cctggctgat gctggcttca tcaagcaata tggagactgt 2520 ctggggagaca ttgctgccag ggacctgatt tgtgcccaga agttcaatgg actgacagtg 2580 ctgcctccac tgctgacaga tgagatgatt gcccaataca cctctgccct gctggctggc 2640 accatcacct ctggctggac ctttggagca ggagcagccc tccaaatccc atttgctatg 2700 cagatggctt acaggttcaa tggcattgga gtgacccaga atgtgctcta tgagaaccag 2760 aaactgattg ccaaccagtt caactctgcc attggcaaga ttcaggactc cctgtccagc 2820 acagcctctg ccctgggcaa actccaagat gtggtgaacc agaatgccca ggctctgaac 2880 accctggtga agcaactttc cagcaacttt ggagccatct cctctgtgct gaatgacatc 2940 ctgagcagac tggacaaggt ggaggctgag gtccagattg acagactgat tacaggcaga 3000 3060 tctgccaacc tggctgccac caagatgagt gagtgtgtgc tgggacaaag caagagggtg 3120 gacttctgtg gcaagggcta ccacctgatg agttttccac agtctgcccc tcatggagtg 3180 gtgttcctgc atgtgaccta tgtgcctgcc caggagaaga acttcaccac agcccctgcc 3240 atctgccatg atggcaaggc tcactttcca agggagggag tgtttgtgag caatggcacc 3300 cactggtttg tgacccagag gaacttctat gaaccacaga ttatcaccac agacaacacc 3360 tttgtgtctg gcaactgtga tgtggtgatt ggcattgtga acaacagt ctatgaccca 3420 ctccaacctg aactggactc cttcaaggag gaactggaca aatacttcaa gaaccacacc 3480 agccctgatg tggacctggg agacatctct ggcatcaatg cctctgtggt gaacatccag 3540 aaggagattg acagactgaa tgaggtggct aagaacctga atgagtccct gattgacctc 3600 caagaactgg gcaaatatga acaatacatc aagtggccat ga 3642 <210> 4 <211> 37 <212> DNA <213> artificial sequence <220> <223> spike protein ending gene forward primer <400> 4 tccagcctcc gatttgccac catgtttgtg ttcctgg 37 <210> 5 <211> 39 <212> DNA <213> artificial sequence <220> <223> spike protein ending gene reverse primer <400> 5 gattatgatc aattttcatg gccacttgat gtattgttc 39 <210> 6 <211> 24 <212> DNA <213> artificial sequence <220> <223> S1/S2 cleavage site <400> 6 acgaattctc ctcggcgggc acgt 24 <210> 7 <211> 12 <212> DNA <213> artificial sequence <220> <223> linker <400> 7 acgattcctcc gt 12 <210> 8 <211> 3630 <212> DNA <213> artificial sequence <220> <223> spike protein coding sequence in #2 vector <400> 8 atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc 60 aggacccaac ttcctcctgc ctacaccaac tccttcacca gggggagtcta ctaccctgac 120 aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc 180 aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac 240 aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc 300 atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg 360 aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc 420 ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac 480 tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag 540 ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac 600 ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acagggcttc 660 tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc 720 ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca 780 ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat 840 gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag 900 tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc 960 caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag 1020 gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac 1080 tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat 1140 ggaggtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt 1200 gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac 1260 tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac 1320 ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac 1380 ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt 1440 aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc 1500 aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc 1560 cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac 1620 ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg 1680 ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag 1740 accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct 1800 ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg 1860 cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc 1920 aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat 1980 gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaccca gaccatcctc 2040 aggtctgtgg caagccagag catcattgcc tacacaatga gtctggggagc agagaactct 2100 gtggcttaca gcaacaacag cattgccatc ccaaccaact tcaccatctc tgtgaccaca 2160 gagattctgc ctgtgagtat gaccaagacc tctgtggact gtacaatgta tatctgtgga 2220 gacagcacag agtgtagcaa cctgctgctc caatatggct ccttctgtac ccaacttaac 2280 agggctctga caggcattgc tgtggaacag gacaagaaca cccaggaggt gtttgcccag 2340 gtgaagcaga tttacaagac acctccaatc aaggactttg gaggcttcaa cttcagccag 2400 attctgcctg acccaagcaa gccaagcaag aggtccttca ttgaggacct gctgttcaac 2460 aaggtgaccc tggctgatgc tggcttcatc aagcaatatg gagactgtct gggagacatt 2520 gctgccaggg acctgatttg tgcccagaag ttcaatggac tgacagtgct gcctccactg 2580 ctgacagatg agatgattgc ccaatacacc tctgccctgc tggctggcac catcacctct 2640 ggctggacct ttggagcagg agcagccctc caaatcccat ttgctatgca gatggcttac 2700 aggttcaatg gcattggagt gacccagaat gtgctctatg agaaccagaa actgattgcc 2760 aaccagttca actctgccat tggcaagatt caggactccc tgtccagcac agcctctgcc 2820 ctgggcaaac tccaagatgt ggtgaaccag aatgcccagg ctctgaacac cctggtgaag 2880 caactttcca gcaactttgg agccatctcc tctgtgctga atgacatcct gagcagactg 2940 gacaaggtgg aggctgaggt ccagattgac agactgatta caggcagact ccaatccctc 3000 caaacctatg tgacccaaca acttatcagg gctgctgaga ttagggcatc tgccaacctg 3060 gctgccacca agatgagtga gtgtgtgctg ggacaaagca agagggtgga cttctgtggc 3120 aagggctacc acctgatgag ttttccacag tctgcccctc atggagtggt gttcctgcat 3180 gtgacctatg tgcctgccca ggagaagaac ttcaccacag cccctgccat ctgccatgat 3240 ggcaaggctc actttccaag ggaggggagtg tttgtgagca atggcaccca ctggtttgtg 3300 acccagagga acttctatga accacagatt atcaccacag acaacacctt tgtgtctggc 3360 aactgtgatg tggtgattgg cattgtgaac aacacagtct atgacccact ccaacctgaa 3420 ctggactcct tcaaggagga actggacaaa tacttcaaga accacaccag ccctgatgtg 3480 gacctgggag acatctctgg catcaatgcc tctgtggtga acatccagaa ggagattgac 3540 agactgaatg aggtggctaa gaacctgaat gagtccctga ttgacctcca agaactgggc 3600 aaatatgaac aatacatcaa gtggccatga 3630 <210> 9 <211> 31 <212> DNA <213> artificial sequence <220> <223> forward primer <400> 9 agaccatcct caggtctgtg gcaagccaga g 31 <210> 10 <211> 30 <212> DNA <213> artificial sequence <220> <223> reverse primer <400> 10 cctcctacca gacccagacc atcctcaggt 30 <210> 11 <211> 27 <212> DNA <213> artificial sequence <220> <223> linker <400> 11 accggtggcg gtgggtcgag gtctgtg 27 <210> 12 <211> 3639 <212> DNA <213> artificial sequence <220> <223> spike protein coding sequence in #3 vector <400> 12 atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc 60 aggacccaac ttcctcctgc ctacaccaac tccttcacca gggggagtcta ctaccctgac 120 aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc 180 aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac 240 aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc 300 atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg 360 aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc 420 ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac 480 tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag 540 ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac 600 ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acagggcttc 660 tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc 720 ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca 780 ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat 840 gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag 900 tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc 960 caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag 1020 gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac 1080 tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat 1140 ggaggtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt 1200 gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac 1260 tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac 1320 ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac 1380 ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt 1440 aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc 1500 aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc 1560 cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac 1620 ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg 1680 ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag 1740 accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct 1800 ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg 1860 cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc 1920 aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat 1980 gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaccca gaccggtggc 2040 ggtgggtcga ggtctgtggc aagccagagc atcattgcct acacaatgag tctggggagca 2100 gagaactctg tggcttacag caacaacagc attgccatcc caaccaactt caccatctct 2160 gtgaccacag agattctgcc tgtgagtatg accaagacct ctgtggactg tacaatgtat 2220 atctgtggag acagcacaga gtgtagcaac ctgctgctcc aatatggctc cttctgtacc 2280 caacttaaca gggctctgac aggcattgct gtggaacagg acaagaacac ccaggaggtg 2340 tttgcccagg tgaagcagat ttacaagaca cctccaatca aggactttgg aggcttcaac 2400 ttcagccaga ttctgcctga cccaagcaag ccaagcaaga ggtccttcat tgaggacctg 2460 ctgttcaaca aggtgaccct ggctgatgct ggcttcatca agcaatatgg agactgtctg 2520 ggagacattg ctgccaggga cctgatttgt gcccagaagt tcaatggact gacagtgctg 2580 cctccactgc tgacagatga gatgattgcc caatacacct ctgccctgct ggctggcacc 2640 atcacctctg gctggacctt tggagcagga gcagccctcc aaatcccatt tgctatgcag 2700 atggcttaca ggttcaatgg cattggagtg acccagaatg tgctctatga gaaccagaaa 2760 ctgattgcca accagttcaa ctctgccatt ggcaagattc aggactccct gtccagcaca 2820 gcctctgccc tgggcaaact ccaagatggg gtgaaccaga atgcccaggc tctgaacacc 2880 ctggtgaagc aactttccag caactttgga gccatctcct ctgtgctgaa tgacatcctg 2940 agcagactgg acaaggtgga ggctgaggtc cagattgaca gactgattac aggcagactc 3000 caatccctcc aaacctatgt gacccaacaa cttatcaggg ctgctgagat tagggcatct 3060 gccaacctgg ctgccaccaa gatgagtgag tgtgtgctgg gacaaagcaa gagggtggac 3120 ttctgtggca agggctacca cctgatgagt tttccacagt ctgcccctca tggagtggtg 3180 ttcctgcatg tgacctatgt gcctgcccag gagaagaact tcaccacagc ccctgccatc 3240 tgccatgatg gcaaggctca ctttccaagg gagggagtgt ttgtgagcaa tggcacccac 3300 tggtttgtga cccagaggaa cttctatgaa ccacagatta tcaccacaga caacaccttt 3360 gtgtctggca actgtgatgt ggtgattggc attgtgaaca acacagtcta tgacccactc 3420 caacctgaac tggactcctt caaggaggaa ctggacaaat acttcaagaa ccacaccagc 3480 cctgatgtgg acctgggaga catctctggc atcaatgcct ctgtggtgaa catccagaag 3540 gagattgaca gactgaatga ggtggctaag aacctgaatg agtccctgat tgacctccaa 3600 gaactgggca aatatgaaca atacatcaag tggccatga 3639 <210> 13 <211> 36 <212> DNA <213> artificial sequence <220> <223> forward primer <400> 13 cggtggcggt gggtcgaggt ctgtggcaag ccagag 36 <210> 14 <211> 34 <212> DNA <213> artificial sequence <220> <223> reverse primer <400> 14 gacccaccgc caccggtctg ggtctggtag gagg 34 <210> 15 <211> 57 <212> DNA <213> artificial sequence <220> <223> linker <400> 15 accggtggcg gtgggtcggg cggtggtggg tcgggtggcg gcggttccag gtctgtg 57 <210> 16 <211> 3669 <212> DNA <213> artificial sequence <220> <223> spike protein coding sequence in #4 vector <400> 16 atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc 60 aggacccaac ttcctcctgc ctacaccaac tccttcacca gggggagtcta ctaccctgac 120 aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc 180 aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac 240 aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc 300 atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg 360 aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc 420 ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac 480 tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag 540 ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac 600 ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acagggcttc 660 tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc 720 ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca 780 ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat 840 gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag 900 tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc 960 caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag 1020 gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac 1080 tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat 1140 ggaggtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt 1200 gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac 1260 tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac 1320 ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac 1380 ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt 1440 aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc 1500 aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc 1560 cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac 1620 ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg 1680 ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag 1740 accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct 1800 ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg 1860 cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc 1920 aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat 1980 gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaccca gaccggtggc 2040 ggtgggtcgg gcggtggtgg gtcgggtggc ggcggttcca ggtctgtggc aagccagagc 2100 atcattgcct acacaatgag tctggggagca gagaactctg tggcttacag caacaacagc 2160 attgccatcc caaccaactt caccatctct gtgaccacag agattctgcc tgtgagtatg 2220 accaagacct ctgtggactg tacaatgtat atctgtggag acagcacaga gtgtagcaac 2280 ctgctgctcc aatatggctc cttctgtacc caacttaaca gggctctgac aggcattgct 2340 gtggaacagg acaagaacac ccaggaggtg tttgcccagg tgaagcagat ttacaagaca 2400 cctccaatca aggactttgg aggcttcaac ttcagccaga ttctgcctga cccaagcaag 2460 ccaagcaaga ggtccttcat tgaggacctg ctgttcaaca aggtgaccct ggctgatgct 2520 ggcttcatca agcaatatgg agactgtctg ggagacattg ctgccaggga cctgatttgt 2580 gcccagaagt tcaatggact gacagtgctg cctccactgc tgacagatga gatgattgcc 2640 caatacacct ctgccctgct ggctggcacc atcacctctg gctggacctt tggagcagga 2700 gcagccctcc aaatcccatt tgctatgcag atggcttaca ggttcaatgg cattggagtg 2760 acccagaatg tgctctatga gaaccagaaa ctgattgcca accagttcaa ctctgccatt 2820 ggcaagattc aggactccct gtccagcaca gcctctgccc tgggcaaact ccaagatgtg 2880 gtgaaccaga atgcccaggc tctgaacacc ctggtgaagc aactttccag caactttgga 2940 gccatctcct ctgtgctgaa tgacatcctg agcagactgg acaaggtgga ggctgaggtc 3000 cagattgaca gactgattac aggcagactc caatccctcc aaacctatgt gacccaacaa 3060 cttatcaggg ctgctgagat tagggcatct gccaacctgg ctgccaccaa gatgagtgag 3120 tgtgtgctgg gacaaagcaa gagggtggac ttctgtggca agggctacca cctgatgagt 3180 tttccacagt ctgcccctca tggagtggtg ttcctgcatg tgacctatgt gcctgcccag 3240 gagaagaact tcaccacagc ccctgccatc tgccatgatg gcaaggctca ctttccaagg 3300 gagggagtgt ttgtgagcaa tggcacccac tggtttgtga cccagaggaa cttctatgaa 3360 ccacagatta tcaccacaga caacaccttt gtgtctggca actgtgatgt ggtgattggc 3420 attgtgaaca acacagtcta tgacccactc caacctgaac tggactcctt caaggaggaa 3480 ctggacaaat acttcaagaa ccacaccagc cctgatgtgg acctgggaga catctctggc 3540 atcaatgcct ctgtggtgaa catccagaag gagattgaca gactgaatga ggtggctaag 3600 aacctgaatg agtccctgat tgacctccaa gaactgggca aatatgaaca atacatcaag 3660 tggccatga 3669 <210> 17 <211> 51 <212> DNA <213> artificial sequence <220> <223> forward primer <400> 17 gggcggtggt gggtcgggtg gcggcggttc caggtctgtg gcaagccaga g 51 <210> 18 <211> 49 <212> DNA <213> artificial sequence <220> <223> reverse primer <400> 18 gaccaccac cgcccgaccc accgccaccg gtctgggtct ggtaggagg 49 <210> 19 <211> 7 <212> PRT <213> artificial sequence <220> <223> #3 linker <400> 19 Thr Gly Gly Gly Gly Ser Arg 1 5 <210> 20 <211> 9 <212> PRT <213> artificial sequence <220> <223> #4 linker <400> 20 Thr Gly Gly Gly Gly Ser Arg Arg Arg 1 5 <210> 21 <211> 31091 <212> DNA <213> artificial sequence <220> <223> Adk35F <400> 21 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg t ggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gt gttatca tagcgcgtaa tactgtaata gtaatcaatt 360 acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420 ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt 480 cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540 actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600 aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660 acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720 tacatcaatg ggcgtggata gcggtttgac tcac ggggat ttccaagtct ccaccccatt 780 gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840 aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900 agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960 cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020 agacaccggg accgatccag cctccgattt aaattgatca taatcagcca taccacattt 1080 gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 1140 atgaatgcaa ttgttgttgt taacttgttt attgcagctt at aatggtta caaataaagc 1200 aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 1260 tccaaactca tcaatgtatc ttaacgcgga tctgggcgtg gttaagggtg ggaaagaata 1320 tataaggtgg gggtcttatg tagttttgta tctgttttgc agcagccgcc gccgccatga 1380 gcaccaactc gtttgatgga agcattgtga gctcatattt g acaacgcgc atgcccccat 1440 gggccggggt gcgtcagaat gtgatgggct ccagcattga tggtcgcccc gtcctgcccg 1500 caaactctac taccttgacc tacgagaccg tgtctggaac gccgttggag actgcagcct 1560 ccgccgccgc ttcagccgct gcag ccaccg cccgcgggat tgtgactgac tttgctttcc 1620 tgagcccgct tgcaagcagt gcagcttccc gttcatccgc ccgcgatgac aagttgacgg 1680 ctcttttggc acaattggat tctttgaccc gggaacttaa tgtcgtttct cagcagctgt 1740 tggatctgcg ccagcaggtt tctgccctga aggcttcctc ccctcccaat gcggtttaaa 1800 acataaataa aaaccagac tctgtttgga tttggatcaa g caagtgtct tgctgtcttt 1860 atttaggggt tttgcgcgcg cggtaggccc gggaccagcg gtctcggtcg ttgagggtcc 1920 tgtgtatttt ttccaggacg tggtaaaggt gactctggat gttcagatac atgggcataa 1980 gcccgtctct ggggtgga gg tagcaccact gcagagcttc atgctgcggg gtggtgttgt 2040 agatgatcca gtcgtagcag gagcgctggg cgtggtgcct aaaaatgtct ttcagtagca 2100 agctgattgc caggggcagg cccttggtgt aagtgtttac aaagcggtta agctgggatg 2160 ggtgcatacg tggggatatg agatgcatct tggactgtat ttttaggttg gctatgttcc 2220 cagccatatc cctccgggga ttcatgttgt gcagaaccac cagcacagtg tatccggtgc 2 agg atgagat 2460 cgtcataggc catttttaca aagcgcgggc ggagggtgcc agactgcggt ataatggttc 2520 catccggccc aggggcgtag ttaccctcac agatttgcat ttcccacgct ttgagttcag 2580 atggggggat catgtctacc tgcggggcga tgaagaaaac ggtttccggg gtaggggaga 2640 tcagctggga agaaagcagg ttcctgagca gctgcgactt accgcagccg gtgggcccgt 2700 aaatcacacc tattaccggc tgcaactggt agttaagaga gctgcagctg ccgtcatccc 2760 tgagcagggg ggccacttcg ttaagcatgt ccctgactcg catgttttcc ctgaccaaat 2820 ccgccagaag gcgctcgccg cccagcgata gcagttcttg caaggaagca aagttt ttca 2880 acggtttgag accgtccgcc gtaggcatgc ttttgagcgt ttgaccaagc agttccaggc 2940 ggtcccacag ctcggtcacc tgctctacgg catctcgatc cagcatatct cctcgtttcg 3000 cgggttgggg cggctttcgc tgtacggcag tagtcggtgc tcgtccagac gggccagggt 3060 catgtctttc cacgggcgca gggtcctcgt cagcgtagtc tgggtcacgg tgaaggggtg 3120 cgctccggg c tgcgcgctgg ccagggtgcg cttgaggctg gtcctgctgg tgctgaagcg 3180 ctgccggtct tcgccctgcg cgtcggccag gtagcatttg accatggtgt catagtccag 3240 cccctccgcg gcgtggccct tggcgcgcag cttgcccttg gaggaggcg c cgcacgaggg 3300 gcagtgcaga cttttgaggg cgtagagctt gggcgcgaga aataccgatt ccggggagta 3360 ggcatccgcg ccgcaggccc cgcagacggt ctcgcattcc acgagccagg tgagctctgg 3420 ccgttcgggg tcaaaaacca ggtttccccc atgctttttg atgcgtttct tacctctggt 3480 ttccatgagc cggtgtccac gctcggtgac gaaaaggctg tccgtgtccc cgtatacaga 3540 cttgagaggc ct gtcctcga gcggtgttcc gcggtcctcc tcgtatagaa actcggacca 3600 ctctgagaca aaggctcgcg tccaggccag cacgaaggag gctaagtggg aggggtagcg 3660 gtcgttgtcc actagggggt ccactcgctc cagggtgtga agacacatgt cgccctcttc 3720 ggcatcaagg aaggtgattg gtttgtaggt gtaggccacg tgaccgggtg ttcctgaagg 3780 ggggctataa aagggggtgg gggcgcgttc gtcctcactc tcttccgcat cgctgtctgc 3840 gagggccagc tgttggggtg agtactccct ctgaaaagcg ggcatgactt ctgcgctaag 3900 attgtcagtt tccaaaaacg aggaggattt gatattcacc tggcccgcgg tgatgccttt 3960 gagggtggcc gcatccatct ggtcaga aaa gacaatcttt ttgttgtcaa gcttggtggc 4020 aaacgacccg tagagggcgt tggacagcaa cttggcgatg gagcgcaggg tttggttttt 4080 gtcgcgatcg gcgcgctcct tggccgcgat gtttagctgc acgtattcgc gcgcaacgca 4140 ccgccattcg ggaaagacgg tggtgcgctc gtcgggcacc aggtgcacgc gccaaccgcg 4200 gttgtgcagg gtgacaaggt caacgctggt ggctacctct ccgcgtaggc gctcgttggt 4260 ccagcagagg cggccgccct tgcgcgagca gaatggcggt agggggtcta gctgcgtctc 4320 gtccgggggg tctgcgtcca cggtaaagac cccgggcagc aggcgcgcgt cgaagtagtc 4380 tatcttgcat ccttgcaagt ctagcgcctg ctgccat gcg cgggcggcaa gcgcgcgctc 4440 gtatgggttg agtgggggac cccatggcat ggggtgggtg agcgcggagg cgtacatgcc 4500 gcaaatgtcg taaacgtaga ggggctctct gagtattcca agatatgtag ggtagcatct 4560 tccaccgcgg atgctggcgc gcacgtaatc gtatagttcg tgcgagggag cgaggaggtc 4620 gggaccgagg ttgctacggg cgggctgctc tgctcggaag actatctgcc tgaagatggc 4680 atgtgagttg gatgatatgg ttggacgctg gaagacgttg aagctggcgt ctgtgagacc 4740 taccgcgtca cgcacgaagg aggcgtagga gtcgcgcagc ttgttgacca gctcggcggt 4800 gacctgcacg tctagggcgc agtagtccag ggtttccttg atgatgtcat acttatcctg 4860 tccctttttt ttccacagct cgcggttgag gacaaactct tcgcggtctt tccagtactc 4920 ttggatcgga aacccgtcgg cctccgaacg gtaagagcct agcatgtagagg actttgac 4980 ggcctggtag gcgcagcatc cct tttctac gggtagcgcg tatgcctgcg cggccttccg 5040 gagcgaggtg tgggtgagcg caaaggtgtc cctgaccatg actttgaggt actggtattt 5100 gaagtcagtg tcgtcgcatc cgccctgctc ccagagcaaa aagtccgtgc gctttttgga 5160 acgcggattt ggcagggcga aggtgacatc gttgaagagt atctttcccg cgcgaggcat 5220 aaagttgcgt gtgatgcgga agggtcccgg cacctcggaa cggttgttaa ttacctgggc 5280 ggcgagcacg atctcgtcaa agccgttgat gttgtggccc acaatgtaaa gttccaagaa 5340 gcgcgggatg cccttgatgg aaggcaattt tttaagttcc tcggttagga gctcttcagg 5400 ggagctgagc ccgtgctctg aaagggcc ca gtctgcaaga tgagggttgg aagcgacgaa 5460 tgagctccac aggtcacggg ccattagcat ttgcaggtgg tcgcgaaagg tcctaaactg 5520 gcgacctatg gccatttttt ctggggtgat gcagtagaag gtaagcgggt cttgttccca 5580 gcggtcccat ccaaggttcg cggctaggtc tcgcgcggca gtcactagag gctcatctcc 5640 gccgaacttc atgaccagca tgaagggcac gagctgcttc ccaaaggccc ccatccaagt 5700 ataggtctct acatcgtagg tgacaaagag acgctcggtg cgaggatgcg agccgatcgg 5760 gaagaactgg atctcccgcc accaattgga ggagtggcta ttgatgtggt gaaagtagaa 5820 gtccctgcga cgggccgaac actcgtgctg gcttttgtaa aaacgtgcgc agtactggca 5 880 gcggtgcacg ggctgtacat cctgcacgag gttgacctga cgaccgcgca caaggaagca 5940 gagtgggaat ttgagcccct cgcctggcgg gtttggctgg tggtcttcta cttcggctgc 6000 ttgtccttga ccgtctggct gctcgagggg agttacggtg gatcggacca ccacgccgcg 6060 cgagcccaaa gtccagatgt ccgcgcgcgg cggtcggagc ttgatgacaa catcgcgcag 612 0 atgggagctg tccatggtct ggagctcccg cggcgtcagg tcaggcggga gctcctgcag 6180 gtttacctcg catagacggg tcagggcgcg ggctagatcc aggtgatacc taatttccag 6240 gggctggttg gtggcggcgt cgatggcttg caagaggccg catccccgcg g cgcgactac 6300 ggtaccgcgc ggcgggcggt gggccgcggg ggtgtccttg gatgatgcat ctaaaagcgg 6360 tgacgcgggc gagcccccgg aggtaggggg ggctccggac ccgccgggag agggggcagg 6420 ggcacgtcgg cgccgcgcgc gggcaggagc tggtgctgcg cgcgtaggtt gctggcgaac 6480 gcgacgacgc ggcggttgat ctcctgaatc tggcgcctct gcgtgaagac gacgggcccg 6540 gtgagctt ga acctgaaaga gagttcgaca gaatcaattt cggtgtcgtt gacggcggcc 6600 tggcgcaaaa tctcctgcac gtctcctgag ttgtcttgat aggcgatctc ggccatgaac 6660 tgctcgatct cttcctcctg gagatctccg cgtccggctc gctccacggt gg cggcgagg 6720 tcgttggaaa tgcgggccat gagctgcgag aaggcgttga ggcctccctc gttccagacg 6780 cggctgtaga ccacgccccc ttcggcatcg cgggcgcgca tgaccacctg cgcgagattg 6840 agctccacgt gccgggcgaa gacggcgtag tttcgcaggc gctgaaagag gtagttgagg 6900 gtggtggcgg tgtgttctgc cacgaagaag tacataaccc agcgtcgcaa cgtggattcg 6960 ttgatatccc ccaaggcctc aaggcgctcc atggcctcgt agaagtccac ggcgaagttg 7020 aaaaactggg agttgcgcgc cgacacggtt aactcctcct ccagaagacg gatgagctcg 7080 gcgacagtgt cgcgcacctc gcgctcaaag gctacagggg cctcttcttc ttcttcaatc 7140 tcctct tcca taagggcctc cccttcttct tcttctggcg gcggtggggg aggggggaca 7200 cggcggcgac gacggcgcac cgggaggcgg tcgacaaagc gctcgatcat ctccccgcgg 7260 cgacggcgca tggtctcggt gacggcgcgg ccgttctcgc gggggcgcag ttggaagacg 7320 ccgcccgtca tgtcccggtt atgggttggc ggggggctgc catgcggcag ggatacggcg 7380 ctaacgatgc atctcaacaa ttgttgtgta ggtactccgc cgccgaggga cctgagcgag 7440 tccgcatcga ccggatcgga aaacctctcg agaaaggcgt ctaaccagtc acagtcgcaa 7500 ggtaggctga gcaccgtggc gggcggcagc gggcggcggt cggggttgtt tctggcggag 7560 gtgctgctga tgatgtaatt aaagtaggcg gtcttgagac ggcggatggt cgacagaagc 7620 accatgtcct tgggtccggc ctgctgaatg cgcaggcggt cggccatgcc ccaggcttcg 7680 ttttgacatc ggcgcaggtc tttgtagtag tcttgcatga gcctttctac cggcacttct 7740 tcttctcctt cctcttgtcc tgcatctctt gcatctatcg ctgcggcggc ggcggagttt 7800 ggccgtaggt ggcgccctct tcctcccatg cgtgtgaccc cgaagcccct catcggctga 7860 agcagggcta ggtcggcgac aacgcgctcg gctaatatgg cctgctgcac ctgcgtgagg 7920 gtagactgga agtcatccat gtccacaaag cggtggtatg cgcccgtgtt gatggtgtaa 7980 gtgcagttgg ccataacgga ccagttaac g gtctggtgac ccggctgcga gagctcggtg 8040 tacctgagac gcgagtaagc cctcgagtca aatacgtagt cgttgcaagt ccgcaccagg 8100 tactggtatc ccaccaaaaa gtgcggcggc ggctggcggt agaggggcca gcgtagggtg 8160 gccggggctc cgggggcgag atcttccaac ataaggcgat gatatccgta gatgtacctg 8220 gacatccagg tgatgccggc ggcggtggtg gaggcgcgcg gaaagtcg a gggtatcat ggcggacgac cggggttcga gccccgtatc 8460 cggccgtccg ccgtgatcca tgcggttacc gcccgcgtgt cgaacccagg tgtgcgacgt 8520 cagacaacgg gggagtgctc cttttggctt ccttccaggc gcggcggctg ctgcgctagc 8580 ttttttggcc actggccgcg cgcagcgtaa gcggttaggc tggaaagcga aagcattaag 8640 tggctcgctc cctgtagccg gagggttatt ttccaagggt tgagtcgcgg gaccccc ggt 8700 tcgagtctcg gaccggccgg actgcggcga acgggggttt gcctccccgt catgcaagac 8760 cccgcttgca aattcctccg gaaacaggga cgagcccctt ttttgctttt cccagatgca 8820 tccggtgctg cggcagatgc gcccccctcc tcagcag cgg caagagcaag agcagcggca 8880 gacatgcagg gcaccctccc ctcctcctac cgcgtcagga ggggcgacat ccgcggttga 8940 cgcggcagca gatggtgatt acgaaccccc gcggcgccgg gcccggcact acctggactt 9000 ggaggagggc gagggcctgg cgcggctagg agcgccctct cctgagcggc acccaagggt 9060 gcagctgaag cgtgatacgc gtgaggcgta cgtgccgcgg cagaacctgt ttcgcgaccg 9120 cgagggag gagccc gagg agatgcggga tcgaaagttc cacgcagggc gcgagctgcg 9180 gcatggcctg aatcgcgagc ggttgctgcg cgaggaggac tttgagcccg acgcgcgaac 9240 cgggattagt cccgcgcgcg cacacgtggc ggccgccgac ctggtaaccg cat acgagca 9300 gacggtgaac caggagatta actttcaaaa aagctttaac aaccacgtgc gtacgcttgt 9360 ggcgcgcgag gaggtggcta taggactgat gcatctgtgg gactttgtaa gcgcgctgga 9420 gcaaaaccca aatagcaagc cgctcatggc gcagctgttc cttatagtgc agcacagcag 9480 ggacaacgag gcattcaggg atgcgctgct aaacatagta gagcccgagg gccgctggct 9540 gctcgatttg ataaacatcc tgca ctga aggtgc ttaccttgag cgacgacctg ggcgtttatc gcaacgagcg 9780 catccacaag gccgtgagcg tgagccggcg gcgcgagctc agcgaccgcg agctgatgca 9840 cagcctgcaa agggccctgg ctggcacggg cagcggcgat agagaggccg agtcctactt 9900 tgacgcgggc gctgacctgc gctgggcccc aagccgacgc gccctggagg cagctggggc 9960 cggacctggg ctggcggtgg cacccgcgc g cgctggcaac gtcggcggcg tggaggaata 10020 tgacgaggac gatgagtacg agccagagga cggcgagtac taagcggtga tgtttctgat 10080 cagatgatgc aagacgcaac ggacccggcg gtgcgggcgg cgctgcagag ccagccgtcc 10140 ggcctta act ccacggacga ctggcgccag gtcatggacc gcatcatgtc gctgactgcg 10200 cgcaatcctg acgcgttccg gcagcagccg caggccaacc ggctctccgc aattctgggaa cagcggca ac gtgcagacca acctggaccg gctggtgggg 10440 gatgtgcgcg aggccgtggc gcagcgtgag cgcgcgcagc agcagggcaa cctgggctcc 10500 atggttgcac taaacgcctt cctgagtaca cagcccgcca acgtgccgcg gggacaggag 10560 gactacac ca actttgtgag cgcactgcgg ctaatggtga ctgagacacc gcaaagtgag 10620 gtgtaccagt ctgggccaga ctattttttc cagaccagta gacaaggcct gcagaccgta 10680 aacctgagcc aggctttcaa aaacttgcag gggctgtggg gggtgcgggc tcccacaggc 10740 gaccgcgcga ccgtgtctag cttgctgacg cccaactcgc gcctgttgct gctgctaata 10800 gcgcccttca cggacagtgg cagcgtgtcc cgggacacat acctaggtca cttgctgaca 10860 ctgtaccgcg aggccatagg tcaggcgcat gtggacgagc atactttcca ggagattaca 10920 agtgtcagcc gcgcgctggg gcaggaggac acgggcagcc tggaggcaac cctaaactac 10980 ctgctgacca accggcggca gaagatcccc tc gttgcaca gtttaaacag cgaggaggag 11040 cgcattttgc gctacgtgca gcagagcgtg agccttaacc tgatgcgcga cggggtaacg 11100 cccagcgtgg cgctggacat gaccgcgcgc aacatggaac cgggcatgta tgcctcaaac 11160 cggccgttta tcaaccgcct aatggactac ttgcatcgcg cggccgccgt gaaccccgag 11220 tatttcacca atgccatctt gaacccgcac tggctaccgc cccctggttt ctacaccggg 11280 ggattcgagg tgcccgaggg taacgatgga ttcctctggg acgacataga cgacagcgtg 11340 ttttccccgc aaccgcagac cctgctagag ttgcaacagc gcgagcaggc agaggcggcg 11400 ctgcgaaagg aaagcttccg caggccaagc agcttgtccg atctaggcgc tgcggccccg 11460 cggtcagatg ctagtagccc atttccaagc ttgatagggt ctcttaccag cactcgcacc 11520 acccgcccgc gcctgctggg cgaggaggag tacctaaaca actcgctgct gcagccgcag 11580 cgcgaaaaaa acctgcctcc ggcatttccc aacaacggga tagagagcct agtggacaag 11640 atgagtagat ggaagacgta cgcgcaggag cacagggacg tgccaggccc gcgcccgccc 11700 acccgt cgtc aaaggcacga ccgtcagcgg ggtctggtgt gggaggacga tgactcggca 11760 gacgacagca gcgtcctgga tttgggaggg agtggcaacc cgtttgcgca ccttcgcccc 11820 aggctgggga gaatgtttta aaaaaaaaaa agcatgatgc aaa ataaaaa actcaccaag 11880 gccatggcac cgagcgttgg ttttcttgta ttccccttag tatgcggcgc gcggcgatgt 11940 atgaggaagg tcctcctccc tcctacgaga gtgtggtgag cgcggcgcca gtggcggcgg 12000 cgctgggttc tcccttcgat gctcccctgg acccgccgtt tgtgcctccg cggtacctgc 12060 ggcctaccgg ggggagaaac agcatccgtt actctgagtt ggcaccccta ttcgacacca 12120 cccgt gtgta cctggtggac aacaagtcaa cggatgtggc atccctgaac taccagaacg 12180 accacagcaa ctttctgacc acggtcattc aaaacaatga ctacagcccg ggggaggcaa 12240 gcacacagac catcaatctt gacgaccggt cgcactgggg cggcgacctg aaaaccatcc 12300 tgcataccaa catgccaaat gtgaacgagt tcatgtttac caataagttt aaggcgcggg 12360 tgatggtgtc gcgcttgcct actaaggaca atcaggtgga gctgaaatac gagtgggtgg 12420 agttcacgct gcccgagggc aactactccg agaccatgac catagacctt atgaacaacg 12480 cgatcgtgga gcactacttg aaagtgggca gacagaacgg ggttctgggaa agcgacatcg 12540 gggtaaagtt tgacacccgc aact tcagac tggggtttga ccccgtcact ggtcttgtca 12600 tgcctggggt atatacaaac gaagccttcc atccagacat cattttgctg ccaggatgcg 12660 gggtggactt cacccacagc cgcctgagca acttgttggg catccgcaag cggcaaccct 12720 tccaggagg g ctttaggatc acctacgatg atctggaggg tggtaacatt cccgcactgt 12780 tggatgtgga cgcctaccag gcgagcttga aagatgacac cgaacagggc gggggtggcg 12840 caggcggcag caacagcagt ggcagcggcg cggaagagaa ctccaacgcg gcagccgcgg 12900 caatgcagcc ggtggaggac atgaacgatc atgccattcg cggcgacacc tttgccacac 12960 gggctgagga gaagcgcgct gaggccgaag cagcggccga agctgccgcc cccgctgcgc 13020 aacccgaggt cgagaagcct cagaagaaac cggtgatcaa acccctgaca gaggacagca 13080 agaaacgcag ttacaaccta ataagcaatg acagcacctt cacccagtac cgcagctggt 13140 accttgcata caactacggc gaccctcaga ccggaatccg ctcatggacc ctgctttgca 13200 ctcctgacgt aacctgcggc tcggagcagg tctactggtc gttgccagac atgatgcaag cg agaaccag attttggcgc 13440 gcccgccagc ccccaccatc accaccgtca gtgaaaacgt tcctgctctc acagatcacg 13500 ggacgctacc gctgcgcaac agcatcggag gagtccagcg agtgaccatt actgacgcca 13560 gacgccgcac ctgcccctac gt ttacaagg ccctgggcat agtctcgccg cgcgtcctat 13620 cgagccgcac tttttgagca agcatgtcca tccttatatc gcccagcaat aacacaggct 13680 ggggcctgcg cttcccaagc aagatgtttg gcggggccaa gaagcgctcc gaccaacacc 13740 cagtgcgcgt gcgcgggcac taccgcgcgc cctggggcgc gcacaaacgc ggccgcactg 13800 ggcgcaccac cgtcgatgac gccatcgacg cggt c gcccaacgc gcggcggcgg ccctgcttaa ccgcgcacgt cgcaccggcc 14040 gacgggcggc catgcgggcc gctcgaaggc tggccgcggg tattgtcact gtgcccccca 14100 ggtccaggcg acgagcggcc gccgcagcag ccgcggccat tagtgctatg actcagggtc 14160 gcaggggcaa cgtgtattgg gtgcgcgact cggttagcgg cctgcgcgtg cccgtgcgca 14220 cccgcccccc gcgcaactag attgcaagaa aaaactactt agactcgtac tgttgtatgt 1 4280 atccagcggc ggcggcgcgc aacgaagcta tgtccaagcg caaaatcaaa gaagagatgc 14340 tccaggtcat cgcgccggag atctatggcc ccccgaagaa ggaagagcag gattacaagc 14400 cccgaaagct aaagcgggtc aaaaagaaaa agaaagatga tgatgatgaa cttgacgacg 14460 aggtggaact gctgcacgct accgcgccca ggcgacgggt acagtggaaa ggtcgacgcg 14520 taaaacgtgt tttgcgaccc ggcaccacg tagtcttac gcccggtgag cgctccaccc 14580 gcacctacaa gcgcgtgtat gatgaggtgt acggcgacga ggacctgctt gagcaggcca 14640 acgagcgcct cggggagttt gcctacggaa agcggcataa ggacatgctg gcgttgccgc 14700 tggacgaggg caacccaaca cctagcctaa agcccgtaac actgcagcag gtgctgcccg 14760 cgcttgcacc gtccgaagaa aagcgcggcc taaagcgcga gtctggtgac ttggcaccca 14820 ccgtgcagct gatggtaccc aagcgccagc gactggaaga tgtctt ggaa aaaatgaccg 14880 tggaacctgg gctggagccc gaggtccgcg tgcggccaat caagcaggtg gcgccgggac 14940 tgggcgtgca gaccgtggac gttcagatac ccactaccag tagcaccagt attgccaccg 15000 ccacagaggg catggagaca caaacgtccc cggttgcctc agcggtggcg gatgccgcgg 15060 tgcaggcggt cgctgcggcc gcgtccaaga cctctacgga ggtgcaaacg gacccgtgga 15120 tgttt cgcgt ttcagccccc cggcgcccgc gccgttcgag gaagtacggc gccgccagcg 15180 cgctactgcc cgaatatgcc ctacatcctt ccattgcgcc tacccccggc tatcgtggct 15240 acacctaccg ccccagaaga cgagcaacta cccgacgccg aaccaccact ggaaccc gcc 15300 gccgccgtcg ccgtcgccag cccgtgctgg ccccgatttc cgtgcgcagg gtggctcgcg 15360 aaggaggcag gaccctggtg ctgccaacag cgcgctacca ccccagcatc gtttaaaagc 15420 cggtctttgt ggttcttgca gatatggccc tcacctgccg cctccgtttc ccggtgccgg 15480 gattccgagg aagaatgcac cgtaggaggg gcatggccgg ccacggcctg acgggcggca 15540 tgcgtcgtgc gcacca ccgg cggcggcgcg cgtcgcaccg tcgcatgcgc ggcggtatcc 15600 tgcccctcct tattccactg atcgccgcgg cgattggcgc cgtgcccgga attgcatccg 15660 tggccttgca ggcgcagaga cactgattaa aaacaagttg catgtggaaa aatcaa aata 15720 aaaagtctgg actctcacgc tcgcttggtc ctgtaactat tttgtagaat ggaagacatc 15780 aactttgcgt ctctggcccc gcgacacggc tcgcgcccgt tcatgggaaa a gtggcga aaa gcgtccgcgc cccgacaggg aagaaactct ggtgacgcaa 16200 atagacgagc ctccctcgta cgaggaggca ctaaagcaag gcctgcccac cacccgtccc 16260 atcgcgccca tggctaccgg agtgctgggc cagcacacac ccgtaacgct ggacctgcct 16320 ccccccgccg acacccagca gaaacctgtg ctgccaggcc cgaccgccgt tgttgtaacc 16380 cgtcctagcc gcgcgtccct gcgccgcgcc gccag cggtc cgcgatcgtt gcggcccgta 16440 gccagtggca actggcaaag cacactgaac agcatcgtgg gtctgggggt gcaatccctg 16500 aagcgccgac gatgcttctg atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg 16560 tcgccgccag aggag ctgct gagccgccgc gcgcccgctt tccaagatgg ctaccccttc 16620 gatgatgccg cagtggtctt acatgcacat ctcgggccag gacgcctcgg agtacctgag 16680 ccccgggctg gtgcagtttg cccgcgccac cgagacgtac ttcagcctga ataacaagtt 16740 tagaaacccc acggtggcgc ctacgcacga cgtgaccaca gaccggtccc agcgtttgac 16800 gctgcggttc atccctgtgg accgtgagga tactgcgtac tc gtacaagg cgcggttcac 16860 cctagctgtg ggtgataacc gtgtgctgga catggcttcc acgtactttg acatccgcgg 16920 cgtgctggac aggggcccta cttttaagcc ctactctggc actgcctaca acgccctggc 16980 tcccaagggt gccccaaatc cttgcgaat g ggatgaagct gctactgctc ttgaaataaa 17040 cctagaagaa gaggacgatg acaacgaaga cgaagtagac gagcaagctg agcagcaaaa 17100 aactcacgta tttgggcagg cgccttattc tggtataaat attacaaagg agggtattca 17160 aataggtgtc gaaggtcaaa cacctaaata tgccgataaa acatttcaac ctgaacctca 17220 aataggagaa tctcagtggt acgaaacaga aattaatcat gcagctggga gagtcctaaa 172 80 aaagactacc ccaatgaaac catgttacgg ttcatatgca aaacccacaa atgaaaatgg 17340 agggcaaggc attcttgtaa agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca 17400 attttctca actactgagg cagccgcagg caatggtgat aacttgact c ctaaagtggt 17460 attgtacagt gaagatgtag atatagaaac cccagacact catatttctt acatgcccac 17520 tattaaggaa ggtaactcac gagaactaat gggccaacaa tctatgccca acaggcctaa 17580 ttacattgct tttagggaca atttattgg tctaatgtat tacaacagca cgggtaatat 17640 gggtgttctg gcgggccaag catcgcagtt gaatgctgtt gtagatttgc aagacagaaa 17700 cacagagct t tcataccagc ttttgcttga ttccattggt gatagaacca ggtacttttc 17760 tatgtggaat caggctgttg acagctatga tccagatgtt agaattattg aaaatcatgg 17820 aactgaagat gaacttccaa attactgctt tccactggga ggtgtgatta atacagagac 178 80 tcttaccaag gtaaaaccta aaacaggtca ggaaaatgga tgggaaaaag atgctacaga 17940 attttcagat aaaaatgaaa taagagttgg aaataatttt gccatggaaa tcaatctaaa 18000 tgccaacctg tggagaaatt tcctgtactc caacatagcg ctgtatttgc ccgacaagct 18060 aaagtacagt ccttccaacg taaaaatttc tgataaccca aacacctacg actacatgaa 18120 caagcga gtg gtggctcccg ggctagtgga ctgctacatt aaccttggag cacgctggtc 18180 ccttgactat atggacaacg tcaacccatt taaccaccac cgcaatgctg gcctgcgcta 18240 ccgctcaatg ttgctgggca atggtcgcta tgtgcccttc cacatccagg tg cctcagaa 18300 gttctttgcc attaaaaacc tccttctcct gccgggctca tacacctacg agtggaactt 18360 caggaaggat gttaacatgg ttctgcagag ctccctagga aatgacctaa gggttgacgg 18420 agccagcatt aagtttgata gcatttgcct ttacgccacc ttcttcccca tggcccacaa 18480 caccgcctcc acgcttgagg ccatgcttag aaacgacacc aacgaccagt cctttaacga 18540 ctatctctcc gccgccaaca t gctctaccc tatacccgcc aacgctacca acgtgcccat 18600 atccatcccc tcccgcaact gggcggcttt ccgcggctgg gccttcacgc gccttaagac 18660 taaggaaacc ccatcactgg gctcgggcta cgacccttat tacacctact ctggctctat 18720 accctaccta gatgga acct tttacctcaa ccacaccttt aagaaggtgg ccattacctt 18780 tgactcttct gtcagctggc ctggcaatga ccgcctgctt acccccaacg agtttgaaat 18840 taagcgctca gttgacgggg agggttacaa cgttgcccag tgtaacag tgtaacatga ccaaagactg 18900 gttcctggta caaatgctag ctaactataa cattggctac cagggcttct atatcccaga 18960 gagctacaag gaccgcatgt actccttctt tagaaacttc a gttgacagc attacccaga aaaagtttct 19200 ttgcgatcgc accctttggc gcatcccatt ctccagtaac tttatgtcca tgggcgcact 19260 cacagacctg ggccaaaacc ttctctacgc caactccgcc cacgcgctag acatgacttt 19320 tgaggtggat cccatggacg agcccaccct tctttatgtt ttgtttgaag tctttgacgt 19380 ggtccgtgtg caccagccgc accgcggcgt cat cgaaacc gtgtacctgc gcacgccctt 19440 ctcggccggc aacgccacaa cataaagaag caagcaacat caacaacagc tgccgccatg 19500 ggctccagtg agcaggaact gaaagccatt gtcaaagatc ttggttgtgg gccatatttt 19560 ttgggcacct atgacaagcg ctttccaggc tttgtttctc cacacaagct cgcctgcgcc 19620 atagtcaata cggccggtcg cgagactggg ggcgtacact ggatggcctt tgcctggaac 19680 ccgcactcaa aaacatgcta cctctttgag ccctttggct tttctgacca gcgactcaag 19740 caggtttacc agtttgagta cgagtcactc ctgcgccgta gcgccattgc ttcttccccc 19800 gaccgctgta taacgctgga aaagtccacc caaagcgt ac aggggcccaa ctcggccgcc 19860 tgtggactat tctgctgcat gtttctccac gcctttgcca actggcccca aactcccatg 19920 gatcacaacc ccaccatgaa ccttattacc ggggtaccca actccatgct caacagtccc 19980 caggtacagc ccaccctgcg tcgca accag gaacagctct acagcttcct ggagcgccac 20040 tcgccctact tccgcagcca cagtgcgcag attaggagcg ccacttcttt ttgtcacttg 20100 aaaaacatgt aaaaataatg tactagagac actttcaata aaggcaaatg cttttttg 20160 tacactctcg ggtgattatt tacccccacc cttgccgtct gcgccgttta aaaatcaaag 20220 gggttctgcc gcgcatcgct atgcgccact ggcagggaca cgttgcgata ctggtgttta cga tacacag ggttgcagca ctggaacact 20460 atcagcgccg ggtggtgcac gctggccagc acgctcttgt cggagatcag atccgcgtcc 20520 aggtcctccg cgttgctcag ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag 20580 ggcgcgtgcc caggctttga gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc 20640 ccggtctggg cgttaggata cagcgcctgc ataaaagcct tgatctgctt aaaag ccacc 20700 tgagcctttg cgccttcaga gaagaacatg ccgcaagact tgccggaaaa ctgattggcc 20760 ggacaggccg cgtcgtgcac gcagcacctt gcgtcggtgt tggagatctg caccacattt 20820 cggccccacc ggttcttcac gatcttgg cc ttgctagact gctccttcag cgcgcgctgc 20880 ccgtttcgc tcgtcacatc catttcaatc acgtgctcct tatttatcat aatgcttccg 20940 tgtagacact taagctcgcc ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc 21000 gtgggctcgt gatgcttgta ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat 21060 cgccccatca tcgtcacaaa ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc 2 1120 tcctcgttca gccaggtctt gcatacggcc gccagagctt ccacttggtc aggcagtagt 21180 ttgaagttcg cctttagatc gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc 21240 tccatgccct tctcccacgc agacacgatc ggcac actca gcgggttcat caccgtaatt 21300 tcactttccg cttcgctggg ctcttcctct tcctcttgcg tccgcatacc acgcgccact 21360 gggtcgtctt cattcagccg ccgcactggtg cgcttacctc ctttgccatg cttgattagc 21420 accggtgggt tgctgaaacc caccatttgt agcgccacat cttctctttc ttcctcgctg 21480 tccacgatta cctctggtga tggcgggcgc tcgggcttgg gagaagggcg cttctttttc 21540 t tcttgggcg caatggccaa atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc 21600 ggcaccagcg cgtcttgtga tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc 21660 cgcttttttg ggggcgcccg gggaggcggc ggc gacgggg acggggacga cacgtcctcc 21720 atggttgggg gacgtcgcgc cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc 21780 tcttcccgac tggccatttc cttctcctat aggcagaaaa agatcatgga gtcagtcgag 21840 aagaaggaca gcctaaccgc cccctctgag ttcgccacca ccgcctccac cgatgccgcc 21900 aacgcgccta ccaccttccc cgtcgaggca cccccgcttg aggaggagga agtgattatc 21960 gagcaggacc caggttttgt aagcga tctg cgacgc gttgcaagag cgcagcgatg tgcccctcgc catagcggat 22200 gtcagccttg cctacgaacg ccacctattc tcaccgcgcg taccccccaa acgcccaagaa 22260 aacggcacat gcgagcccaa cccgcgcctc aacttctacc ccgtatttgc cgtgccagag 22320 gtgcttgcca cctatcacat ctttttccaa aactgcaaga tacccctatc ctgccgtgcc 22380 aaccgcagcc gagcggacaa gcagctggcc ttgcgg cagg gcgctgtcat acctgatatc 22440 gcctcgctca acgaagtgcc aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg 22500 gcaaacgctc tgcaacagga aaacagcgaa aatgaaagtc actctgggagt gttggtggaa 22560 ctcgagggt g acaacgcgcg cctagccgta ctaaaacgca gcatcgaggt cacccacttt 22620 gcctacccgg cacttaacct accccccaag gtcatgagca cagtcatgag tgagctgatc 22680 gtgcgccgtg cgcagcccct ggagagggat gcaaatttgc aagaacaaac agaggagggc 22740 ctacccgcag ttggcgacga gcagctagcg cgctggcttc aaacgcgcga gcctgccgac 22800 ttggaggagc gacgcaaact aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc 22860 atgcagcggt tctttgctga cccggagatg cagcgcaagc tagaggaaac attgcactac 22920 acctttcgac agggctacgt acgccaggcc tgcaagatct ccaacgtgga gctctgcaac 22980 ctggtctcct accttggaat t ttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc 23040 acgctcaagg gcgaggcgcg ccgcgactac gtccgcgact gcgtttactt atttctatgc 23100 tacacctggc agacggccat gggcgtttgg cagcagtgct tggaggagtg caacctcaag 23160 gagctgcaga aactgctaaa gcaaaacttg aaggacctat ggacggcctt caacgagcgc 23220 tccgtggccg cgcacctggc ggacatcatt ttccccgaac gcctgcttaa aaccct gcaa 23280 cagggtctgc cagacttcac cagtcaaagc atgttgcaga actttaggaa ctttatccta 23340 gagcgctcag gaatcttgcc cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt 23400 aagtaccgcg aatgccctcc gccgctttgg ggcc actgct accttctgca gctagccaac 23460 taccttgcct accactctga cataatggaa gacgtgagcg gtgacggtct actggagtgt 23520 cactgtcgct gcaacctatg caccccgcac cgctccctgg tttgcaattc gcagctgctt 23580 aacgaaagtc aaattatcgg tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc 23640 gcggctccgg ggttgaaact cactccgggg ctgtggacgt cggcttacct tcgcaaattt 23 700 gtacctgagg actaccacgc ccacgagatt aggttctacg aagaccaatc ccgcccgcct 23760 aatgcggagc ttaccgcctg cgtcattacc cagggccaca ttcttggcca attgcaagcc 23820 atcaacaaag cccgccaaga gtttctgcta cgaaagggac ggggggttta cttggacccc 23880 cagtccggcg aggagctcaa cccaatcccc ccgccgccgc agccctatca gcagcagccg 23940 cgggcccttg cttcccagga tggcacccaa aaagaagctg cagctgccgc cgccacccac 24000 ggacgaggag gaatactggg acagtcaggc agaggaggtt ttggacgagg aggaggagga 24060 catgatggaa gactgggaga gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga 24120 cgaaacaccg tcaccctcgg tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg 24180 ttccagcatg gctacaacct ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc 24240 caaccgtaga tgggaacacca ctggaaccag ggccggtaag tccaagcagc cgccgccgtt 24300 agcccaagag caacaacagc gccaaggcta ccgctcatgg cgcgggcaca agaacgccat 24360 agttgcttgc ttgcaagact gtgggggcaa catctccttc gcccgccgct ttcttctcta 24420 ccatcacggc gtggccttcc cccgtaacat cctgcattac taccgtcatc tctacagccc 24480 atactgcacc ggcggcagcg gcagcaacag cagcggccac acagaagcaa aggcgaccgg 24540 atagcaagac tctgacaaag cccaaga aat ccacagcggc ggcagcagca ggaggaggag 24600 cgctgcgtct ggcgcccaac gaacccgtat cgacccgcga gcttagaaac aggatttttc 24660 ccactctgta tgctatattt caacagagca ggggccaaga acaagagctg aaaataaaaa 24720 acaggt ctct gcgatccctc acccgcagct gcctgtatca caaaagcgaa gatcagcttc 24780 ggcgcacgct ggaagacgcg gaggctctct tcagtaaata ctgcgcgctg actcttaagg 24840 actagtttcg cgccctttct caaatttaag cgcgaaaact acgtcatctc cagcggccac 24900 acccggcgcc agcacctgtt gtcagcgcca ttatgagcaa ggaaattccc acgccctaca 24960 tgtggagtta ccagccacaa atgggacttg cggctgg agc tgcccaagac tactcaaccc 25020 gaataaacta catgagcgcg ggaccccaca tgatatcccg ggtcaacgga atacgcgccc 25080 accgaaaccg aattctcctg gaacaggcgg ctattaccac cacacctcgt aataacctta 25140 atccccgtag ttggcccgct gccct ggtgt accaggaaag tcccgctccc accactgtgg 25200 tacttcccag agacgcccag gccgaagttc agatgactaa ctcaggggcg cagcttgcgg 25260 gcggctttcg tcacagggtg cggtcgcccg ggcagggtat aactcacctg acaatcagag 25320 ggcgaggtat tcagctcaac gacgagtcgg tgagctcctc gcttggtctc cgtccggacg 25380 ggacatttca gatcggcggc gccggccgct ctt cattcac gcctcgtcag gcaatcctaa 25440 ctctgcagac ctcgtcctct gagccgcgct ctggaggcat tggaactctg caatttattg 25500 aggagtttgt gccatcggtc tactttaacc ccttctcggg acctcccggc cactatccgg 25560 atcaatttat tcctaact tt gacgcggtaa aggactcggc ggacggctac gactgaatgt 25620 taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc cgccacaagt 25680 gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat catatcgagg 25740 gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc ctgattcggg 25800 agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt ctc actgtga 25860 tttgcaactg tcctaaccct ggattacatc aagatcctct agttaatgtc aggtcgccta 25920 agtcgattaa ctagagtacc cggggatctt attcccttta actaataaaa aaaaataata 25980 aagcatcact tacttaaaat cagttagcaa atttctgtcc agtttat ca gcagcacctc 26040 cttgccctcc tcccagctct ggtattgcag cttcctcctg gctgcaaact ttctccacaa 26100 tctaaatgga atgtcagttt cctcctgttc ctgtccatcc gcacccacta tcttcatgtt 26160 gttgcagatg aagcgcgcaa gaccgtctga agataccttc aaccccgtgt atccatatga 26220 cacggaaacc ggtcctccaa ctgtgccttt tcttactcct ccctttgtat cccccaatgg 26280 gtttcaagag agtccccctg gggtactctc tttgcgccta tccgaacctc tagttacctc 26340 caatggcatg cttgcgctca aaatgggcaa cggcctctct ctggacgagg ccggcaacct 26400 tacctcccaa aatgtaacca ctgtgagccc acct ctcaaa aaaaccaagt caaacataaa 26460 cctggaaata tctgcacccc tcacagttac ctcagaagcc ctaactgtgg ctgccgccgc 26520 acctctaatg gtcgcgggca acacactcac catgcaatca caggccccgc taaccgtgca 26580 cgactccaaa cttagcattg ccacccaagg acccctcaca gtgtcagaag gaaagctagc 26640 cctgcaaaca tcaggccccc tcaccacacac cgatagcagt acccttacta tcactgcctc 26700 accccctcta act actgcca ctggtagctt gggcattgac ttgaaagagc ccatttatac 26760 acaaaatgga aaactaggac taaagtacgg ggctcctttg catgtaacag acgacctaaa 26820 cactttgacc gtagcaactg gtccaggtgt gactattaat aatacttcct tgcaaactaa 26880 agt tactgga gccttgggtt ttgattcaca aggcaatatg caacttaatg tagcaggagg 26940 actaaggatt gattctcaaa acagacgcct tatacttgat gttagttatc cgtttgatgc 27000 tcaaaaccaa ctaaatctaa gactaggaca gggccctctt tttataaact cagcccacaa 27060 cttggatatt aactacaaca aaggccttta cttgtttaca gcttcaaaca attccaaaaa 27120 gcttgaggtt aacc taagca ctgccaaggg gttgatgttt gacgctacag ccatagccat 27180 taatgcagga gatgggcttg aatttggttc acctaatgca ccaaacacaa atcccctcaa 27240 aacaaaaatt ggccatggcc tagaatttga ttcaaacaag gctatggttc ctaaactagg 27300 aactggcctt agttttgaca gcacaggtgc cattacagta ggaaacaaaa ataatgataa 27360 gctaactttg tggaccggaa taaaccctcc acctaactgt caaattgtgg aaaac actaa 27420 tacaaatgat ggcaaactta ctttagtatt agtaaaaaat ggagggcttg ttaatggcta 27480 cgtgtctcta gttggtgtat cagacactgt gaaccaaatg ttcacacaaa agacagcaaa 27540 catccaatta agattatatt ttgactcttc tggaaat cta ttaactgagg aatcagactt 27600 aaaaattcca cttaaaaata aatcttctac agcgaccagt gaaactgtag ccagcagcaa 27660 agcctttatg ccaagtacta cagcttatcc cttcaacacc actactaggg atagtgaaaa 27720 ctacattcat ggaatatgtt actacatgac tagttatgat agaagtctat ttcccttgaa 27780 catttctata atgctaaaca gccgtatgat ttcttccaat gttgcctatg ccatacaatt 27840 tga atggaat ctaaatgcaa gtgaatctcc agaaagcaac atagctacgc tgaccacatc 27900 cccctttttc ttttcttaca ttacagaaga cgacaactaa agaatcgttt gtgttatgtt 27960 tcaacgtgtt tatttttcaa ttgcagaaaa tttcaagtca t ttttcattc agtagtatag 28020 ccccaccacc acatagctta tacagatcac cgtaccttaa tcaaactcac agaaccctag 28080 tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg 28140 ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg 28200 tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta 28260 agtt catgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa 28320 cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga 28380 tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgcc gccgc tccgtcctgc 28440 aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 28500 gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 28560 agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 28620 tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 28680 gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 28740 cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 28800 agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac 28860 agtggagagc ccaggactc g taaccatgga tcatcatgct cgtcatgata tcaatgttgg 28920 cacaacacag gcaacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 28980 ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 29040 ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 29100 cctccagtat ggtag cgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 29160 gagtgcgccg agacaaccga gatcgtgttg gtcgtagt gt catgccaaat ggaacgccgg 29220 acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 2 9280 cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 29340 tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 29400 acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 29460 cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 29520 atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 29580 aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 29640 aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 29700 ctct ataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 29760 caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 29820 agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 29880 cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 29940 cttcgcaggg ccagctgaac ataatcgtgc aggtctgc ac ggaccagcgc ggccacttcc 30000 ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 30060 ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 30120 ctgctcaaaa aatcaggcaa agcc tcgcgc aaaaaagaaa gcacatcgta gtcatgctca 30180 tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 30240 aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 30300 tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 30360 tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 30420 cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 30480 tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 30540 acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaac ac 30600 ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 30660 cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 30720 aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 30780 agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 3084 0 aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 30900 tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 30960 acacatacaa gttactccgc cctaaaacct acgtcacccg cc ccgttc cc acgccccgcg 31020 ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 31080tattgatgat g 31091 <210> 22 <211> 37678 <212> DNA <213> artificial sequence <220> <223> plasmid #1 vector <400> 22 ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60 aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120 ggctgcggcg agcggtatca gctcactcaa aggcggta at acggttatcc acagaatcag 180 gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240 aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300 gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360 ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420 cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480 cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540 gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600 cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660 agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720 ctctgctgaa gccagttacc ttcgga aaaa gagttggtag ctcttgatcc ggcaaacaaa 780 ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840 gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900 cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960 attaaaaatg aagttttaaa tcaatctaaa gtatata tga gtaaacttgg tctgacagtt 1020 accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080 ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140 gtgctgcaat gataccgcga gacccac gct caccggctcc agatttatca gcaataaacc 1200 agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260 ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320 ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380 cgtagaaagc cagtccgcag aaacggtgct gaccccgg at gaatgtcagc tactgggcta 1440 tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500 ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560 cgccctctgg taaggttggg aagccctg ca aagtaaactg gatggctttc ttgccgccaa 1620 ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680 tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740 gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800 cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860 aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920 tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980 atctcctgtc atctcacctt gctcctgccg aga aagtatc catcatggct gatgcaatgc 2040 ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100 tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160 agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220 gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280 gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340 tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400 tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgcctt ctat cgccttcttg 2460 acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520 gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580 gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640 aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700 gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760 tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820 gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgc gctt 2880 aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940 atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000 tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060 atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120 tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180 aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240 gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 33 00 cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360 gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420 ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480 ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540 atgacggtaa atggcccgcc tggcattatg ccc agtacat gaccttatgg gactttccta 3600 cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660 acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg 3720 acgtcaatgg gagtttgttt tggca ccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780 actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc t gtgttcctg gtgctgctgc 4020 cactggtgtc cagccagtgt gtgaacctga ccaccaggac ccaacttcct cctgcctaca 4080 ccaactcctt caccagggga gtctactacc ctgacaaggt gttcaggtcc tctgtgctgc 4140 acagcaccca ggacctgttc ctgccattct tcagcaatgt gacctggttc catgccatcc 4200 atgtgtctgg caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg 4260 gagtctactt tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca 4320 ccctggacag caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta 4380 aggtgtgtga gttccagttc tgtaatgacc cattcctggg agtctactac cacaagaaca 4440 acaagtcctg gatggagtct gagttcaggg tctactcctc tgccaacaac tgtacctttg 4500 aatatgtgag ccaaccattc ctgatggact tggagggcaa gcagggcaac ttcaagaacc 4560 tgagggagtt tgtgttcaag aacattgatg gctactt caa gatttacagc aaacacacac 4620 caatcaacct ggtgagggac ctgccacagg gcttctctgc cttggaacca ctggtggacc 4680 tgccaattgg catcaacatc accaggttcc agaccctgct ggctctgcac aggtcctacc 4740 tgacacctgg agactcctcc tctggctgga cagcaggagc agcagcctac tatgtgggct 4800 acctccaacc aaggaccttc ctgctgaaat acaatgagaa tggcaccatc acagatg ctg 4860 tggactgtgc cctggaccca ctgtctgaga ccaagtgtac cctgaaatcc ttcacagtgg 4920 agaagggcat ctaccagacc agcaacttca gggtccaacc aacagagagc attgtgaggt 4980 ttccaaacat caccaacctg tgtccatttg gagaggtgtt caatgcca cc aggtttgcct 5040 ctgtctatgc ctggaacagg aagaggatta gcaactgtgt ggctgactac tctgtgctct 5100 acaactctgc ctccttcagc accttcaagt gttatggagt gagcccaacc aaactgaatg 5160 acctgtgttt caccaatgtc tatgctgact cctttgtgat taggggat gaggtgagac 5220 agattgcccc tggacaaaca ggcaagattg ctgactacaa ctacaaactg cctgatgact 5280 t cacaggctg tgtgattgcc tggaacagca acaacctgga cagcaaggtg ggaggcaact 5340 acaactacct ctacagactg ttcaggaaga gcaacctgaa accatttgag agggacatca 5400 gcacagagat ttaccaggct ggcagcacac catgtaatgg agtggagggc ttcaactgtt 5460 act ttccact ccaatcctat ggcttccaac caaccaatgg agtgggctac caaccataca 5520 gggtggtggt gctgtccttt gaactgctcc atgcccctgc cacagtgtgt ggaccaaaga 5580 agagcaccaa cctggtgaag aacaagtgg tgaacttcaa cttcaatgga ctgacaggca 5640 caggagtgct gacagagagc aacaagaagt tcctgccatt ccaacagttt ggcagggaca 5700 ttgctgac ac cacagatgct gtgagggacc cacagacctt ggagattctg gacatcacac 5760 catgttcctt tggaggagtg tctgtgatta cacctggcac caacaccagc aaccaggtgg 5820 ctgtgctcta ccaggatgtg aactgtactg aggtgcctgt ggctatccat gctgaccaac 5880 ttaca ccaac ctggagggtc tacagcacag gcagcaatgt gttccagacc agggctggct 5940 gtctgattgg agcagagcat gtgaacaact cctatgagtg tgacatccca attggagcag 6000 gcatctgtgc ctcctaccag acccagacca acagcccaag gagggcaagg tctgtggcaa 6060 gccagagcat cattgcctac acaatgagtc tgggagcaga gaactctgtg gcttacagca 6120 acaacagcat tgccatccca accaacttca c catctctgt gaccacagag attctgcctg 6180 tgagtatgac caagacctct gtggactgta caatgtatat ctgtggagac agcacagagt 6240 gtagcaacct gctgctccaa tatggctcct tctgtaccca acttaacagg gctctgacag 6300 gcattgctgt ggaacaggac aagaacaccc aggag gtgtt tgcccaggtg aagcagattt 6360 acaagacacc tccaatcaag gactttggag gcttcaactt cagccagatt ctgcctgacc 6420 caagcaagcc aagcaagagg tccttcattg aggacctgct gttcaacaag gtgaccctgg 6480 ctgatgctgg cttcatcaag caatatggag actgtctggg agacattgct gccaggggacc 6540 tgatttgtgc ccagaagttc aatggactga ca gtgctgcc tccactgctg acagatgaga 6600 tgattgccca atacacctct gccctgctgg ctggcaccat cacctctggc tggacctttg 6660 gagcaggagc agccctccaa atcccatttg ctatgcagat ggcttacagg ttcaatggca 6720 ttggagtgac ccagaatgg ctctatgaga accagaaact gattgccaac cagttcaact 6780 ctgccattgg caagattcag gactccctgt ccagcacagc ctctgccctg ggcaaactcc 6840 aagatgtggt gaaccagaat gcccaggctc tgaacaccct ggtgaagcaa ctttccagca 6900 actttggagc catctcctct gtgctgaatg acatcctgag cagactggac aaggtggagg 6960 ctgaggtcca gattgacaga ctgattacag gcagactcca atccctcc aa acctatgtga 7020 cccaacaact tatcagggct gctgagatta gggcatctgc caacctggct gccaccaaga 7080 tgagtgagtg tgtgctggga caaagcaaga gggtggactt ctgtggcaag ggctaccacc 7140 tgatgagttt tccacagtct gcccctcatg gagtggtgtt cctg catgtg acctatgtgc 7200 ctgcccagga gaagaacttc accacagccc ctgccatctg ccatgatggc aaggctcact 7260 ttccaaggga gggagtgttt gtgagcaatg gcacccactg gtttgtgacc cagaggaact 7320 tctatgaacc acagattatc accacagaca acacctttgt gtctggcaac tgtgatgtgg 7380 tgattggcat tgtgaacaac acagtctatg acccactcca acctgaactg gactcc ttca 7440 aggaggaact ggacaaatac ttcaagaacc acaccagccc tgatgtggac ctgggagaca 7500 tctctggcat caatgcctct gtggtgaaca tccagaagga gattgacaga ctgaatgagg 7560 tggctaagaa cctgaatgag tccctgattg acctccaaga actgggcaaa ta tgaacaat 7620 acatcaagtg gccatgaaaa ttgatcataa tcagccatac cacatttgta gaggttttac 7680 ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 7740 ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 7800 atttcacaaa taaagcattt ttttcactgc attctagttg tggttt gtcc aaactcatca 7860 atgtatctta acgcggatct gggcgtggtt aagggtggga aagaatatat aaggtggggg 7920 tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca ccaactcgtt 7980 tgatggaagc attgtgagct catatttgac aacgc gcatg cccccatggg ccggggtgcg 8040 tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa actctactac 8100 cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg ccgccgcttc 8160 agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga gcccgcttgc 8220 aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc tttt ggcaca 8280 attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg atctgcgcca 8340 gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa 8400 accagactct gtttggattt ggatcaagca agtgtcttgc t gtcttatt taggggtttt 8460 gcgcgcgcgg taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc 8520 caggacgtgg taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg 8580 gtggaggtag caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc 8640 gtagcaggag cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag 8700 gggcagg ccc ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg 8760 ggatatgaga tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct 8820 ccggggattc atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt 8880 gt catgtagc ttagaaggaa atgcgtgggaa gaacttggag acgcccttgt gacctccaag 8940 attttccatg cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa 9000 gatatttctg ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat 9060 ttttacaaag cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg 9120 ggcgtagtta ccctcac aga tttgcatttc ccacgctttg agttcagatg gggggatcat 9180 gtctacctgc ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga 9240 aagcaggttc ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat 9 300 taccggctgc aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc 9360 cacttcgtta agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg 9420 ctcgccgccc agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc 9480 gtccgccgta ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc 9540 ggtcacctgc tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg 9600 ctttcgctgt acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac 9660 gggcgcaggg tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tcc gggctgc 9720 gcgctggcca gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg 9780 ccctgcgcgt cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg 9840 tggcccttgg cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt 9900 ttgagggcgt agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg 9960 caggccccgc agacggtctc gcattcc acg agccaggtga gctctggccg ttcggggtca 10020 aaaaccaggt ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg 10080 tgtccacgct cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg 10140 tcc tcgagcg gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag 10200 gctcgcgtcc aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact 10260 agggggtcca ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag 10320 gtgattggtt tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag 10380 ggggtggggg cgcgttcgtc ctcactctct tccgcatc c agaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag 10620 agggcgttgg acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg 10680 cgctccttgg ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga 10740 aagacggtgg tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg 10800 acaaggtcaa cgctggtggc tacctctccg cgtag gcgct cgttggtcca gcagaggcgg 10860 ccgcccttgc gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct 10920 gcgtccacgg taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct 10980 tgcaagtcta g cgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt 11040 gggggacccc atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa 11100 acgtagaggg gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg 11160 ctggcgcgca cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg 11220 ctacgggcgg gctgctctgc tcggaagact atctgcctga agatggcatg tgagttgg at 11280 gatatggttg gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc 11340 acgaaggagg cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct 11400 agggcgcagt agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc 11460 cacagctcgc ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac 11520 ccgtcggcct ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg 11580 cagcatccct tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg 11640 gtgagcgcaa aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg 11700 tcgcatccgc cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc 11760 agggcgaagg tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg 11820 atgcggaagg gtcccggcac ctcggaacgg t tgttaatta cctgggcggc gagcacgatc 11880 tcgtcaaagc cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc 11940 ttgatggaag gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg 12000 tgctctgaaa gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg 12060 tcacgggcca ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc 12120 atttttt ctg gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca 12180 aggttcgcgg ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg 12240 accagcatga agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca 1 2300 tcgtaggtga caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc 12360 tcccgccacc aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg 12420 gccgaacact cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc 12480 tgtacatcct gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg 12540 agcccctcgc ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg 12600 tctggctgct cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc 12660 cagatgtccg cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc 12720 atggtctgga gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat 12780 agacgggtca gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg 12840 gcggcgtcga tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc 12900 gggcggtggg ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag 12960 cccccggagg tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc 13020 cgcgcgcggg caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc 13080 ggttgatctc ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agctt gaacc 13140 tgaaagagag ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct 13200 cctgcacgtc tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt 13260 cctcctggag atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc 13320 gggccatgag ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca 13380 cgcccccttc ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc 13440 gggcgaagac ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt 13500 gttctgccac gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca 13560 aggcctca ag gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt 13620 tgcgcgccga cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc 13680 gcacctcgcg ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa 13740 gggcctcccc ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac 13800 ggcgcaccgg gaggcggtcg acaaagcgct cgatcat ctc cccgcggcga cggcgcatgg 13860 tctcggtgac ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt 13920 cccggttatg ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc 13980 tcaacaattg ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg 14040 gatcggaaaa cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca 14100 ccgtggcggg cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga 14160 tgtaattaaa gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg 14220 gtccggcctg ctgaatgcgc aggcggtcgg ccatgcccca ggcttc gttt tgacatcggc 14280 gcaggtcttt gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct 14340 cttgtcctgc atctcttgca tctatcgctg cggcggcggc ggaggtttggc cgtaggtggc 14400 gccctcttcc tcccatgc gt gtgaccccga agcccctcat cggctgaagc agggctaggt 14460 cggcgacaac gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt 14520 catccatgtc cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca 14580 taacggacca gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg 14640 agtaagccct cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatcc ca 14700 ccaaaaagtg cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg 14760 gggcgagatc ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga 14820 tgccggcggc ggtggtggag gcgcgcggaa agtc gcggac gcggttccag atgttgcgca 14880 gcggcaaaaa gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga 14940 cgctctagcg tgcaaaagga gagcctgtaa gcgggcactc ttccgtggtc tggtggataa 15000 attcgcaagg gtatcatggc ggacgaccgg ggttcgagcc ccgtatccgg ccgtccgccg 15060 tgatccatgc ggttaccgcc cgcgtgtcga acccaggtgt gcgacgtcag acaacggggg 15120 agtg ctcctt ttggcttcct tccaggcgcg gcggctgctg cgctagcttt tttggccact 15180 ggccgcgcgc agcgtaagcg gttaggctgg aaagcgaaag cattaagtgg ctcgctccct 15240 gtagccggag ggttattttc caagggttga gtcgcgggac ccccggttcg agtctcggac 15300 cggccggact gcggcgaacg ggggtttgcc tccccgtcat gcaagacccc gcttgcaaat 15360 tcctccggaa acagggacga gccccttttt tgcttttccc agatgcatcc ggtgctgcgg 15420 cagatgcgcc cccctcctca gcagcggcaa gagcaagagc agcggcagac atgcagggca 15480 ccctcccctc ctcctaccgc gtcaggaggg gcgacatccg cggttgacgc ggcagcagat 15540 ggtgattacg aaccc ccgcg gcgccgggcc cggcactacc tggacttgga ggagggcgag 15600 ggcctggcgc ggctaggagc gccctctcct gagcggcacc caagggtgca gctgaagcgt 15660 gatacgcgtg aggcgtacgt gccgcggcag aacctgtttc gcgaccgcga gggagaggag 15720 cccgaggaga tgcgggatcg aaagttccac gcagggcgcg agctgcggca tggcctgaat 15780 cgcgagcggt tgctgcgcga ggaggacttt gagcccgacg cgcgaaccgg gattagtccc 15840 gcgcgcgcac acgtggcggc cgccgacctg gtaaccgcat acgagcagac ggtgaaccag 15900 gagattaact ttcaaaaaag ctttaacaac cacgtgcgta cgcttgtggc gcgcgaggag 15960 gtggctatag gactgatgca tctgtggg ac tttgtaagcg cgctggagca aaacccaaat 16020 agcaagccgc tcatggcgca gctgttcctt atagtgcagc acagcaggga caacgaggca 16080 ttcagggatg cgctgctaaa catagtagag cccgagggcc gctggctgct cgatttgata 16140 aacatcct gc agagcatagt ggtgcaggag cgcagcttga gcctggctga caaggtggcc 16200 gccatcaact attccatgct tagcctgggc aagttttacg cccgcaagat ataccatacc 16260 ccttacgttc ccatagacaa ggaggtaaag atcgaggggt tctacatgcg catggcgctg 16320 aaggtgctta ccttgagcga cgacctgggc gtttatcgca acgagcgcat ccacaaggcc 16380 gtgagcgtga gccggcggcg cgagctcagc gaccgcga gc tgatgcacag cctgcaaagg 16440 gccctggctg gcacgggcag cggcgataga gaggccgagt cctactttga cgcgggcgct 16500 gacctgcgct gggccccaag ccgacgcgcc ctggaggcag ctggggccgg acctgggctg 16560 gcggtggcac cc gcgcgcgc tggcaacgtc ggcggcgtgg aggaatatga cgaggacgat 16620 gagtacgagc cagaggacgg cgagtactaa gcggtgatgt ttctgatcag atgatgcaag 16680 acgcaacgga cccggcggtg cgggcggcgc tgcagagcca gccgtccggc cttaactcca 16740 cggacgactg gcgccaggtc atggaccgca tcatgtcgct gactgcgcgc aatcctgacg 16800 cgttccggca gcagccgcag gccaaccggc tctccgcaat t ctggaagcg gtggtcccgg 16860 cgcgcgcaaa ccccacgcac gagaaggtgc tggcgatcgt aaacgcgctg gccgaaaaca 16920 gggccatccg gcccgacgag gccggcctgg tctacgacgc gctgcttcag cgcgtggctc 16980 gttacaacag cgg caacgtg cagaccaacc tggaccggct ggtgggggat gtgcgcgagg 17040 ccgtggcgca gcgtgagcgc gcgcagcagc agggcaacct gggctccatg gttgcactaa 17100 acgccttcct gagtacacag cccgccaacg tgccgcgggg acaggaggac tacaccaact 17160 ttgtgagcgc actgcggcta atggtgactg agacaccgca aagtgaggtg taccagtctg 17220 ggccagacta tttttccag accagtagac aaggcctgca gaccgtaaac ctgagcca gg 17280 ctttcaaaaa cttgcagggg ctgtgggggg tgcgggctcc cacaggcgac cgcgcgaccg 17340 tgtctagctt gctgacgccc aactcgcgcc tgttgctgct gctaatagcg cccttcacgg 17400 acagtggcag cgtgtcccgg gacacatacc tag gtcactt gctgacactg taccgcgagg 17460 ccataggtca ggcgcatgtg gacgagcata ctttccagga gattacaagt gtcagccgcg 17520 cgctggggca ggaggacacg ggcagcctgg aggcaaccct aaactacctg ctgaccaacc 17580 ggcggcagaa gatcccctcg ttgcacagtt taaacagcga ggaggagcgc attttgcgct 17640 acgtgcagca gagcgtgagc cttaacctga tgcgcgacgg ggtaacgccc agcgtggcg c 17700 tggacatgac cgcgcgcaac atggaaccgg gcatgtatgc ctcaaaccgg ccgtttatca 17760 accgcctaat ggactacttg catcgcgcgg ccgccgtgaa ccccgagtat ttcaccaatg 17820 ccatcttgaa cccgcactgg ctaccgcccc ctggtttc ta caccggggga ttcgaggtgc 17880 ccgagggtaa cgatggattc ctctgggacg acatagacga cagcgtgttt tccccgcaac 17940 cgcagaccct gctagagttg caacagcgcg agcaggcaga ggcggcgctg cgaaaggaaa 18000 gcttccgcag gccaagcagc ttgtccgatc taggcgctgc ggccccgcgg tcagatgcta 18060 gtagcccatt tccaagcttg atagggtctc ttaccagcac tcgcaccacc cgcccgcgcc 181 20 tgctgggcga ggaggagtac ctaaacaact cgctgctgca gccgcagcgc gaaaaaaacc 18180 tgcctccggc atttcccaac aacgggatag agagcctagt ggacaagatg agtagatgga 18240 agacgtacgc gcaggagcac agggacgtgc caggcccgcg c ccgcccacc cgtcgtcaaa 18300 ggcacgaccg tcagcggggt ctggtgtggg aggacgatga ctcggcagac gacagcagcg 18360 tcctggattt gggagggagt ggcaacccgt ttgcgcacct tcgccccagg ctggggagaa 18420 tgttttaaaa aaaaaaaagc atgatgcaaa ataaaaaact caccaaggcc atggcaccga 18480 gcgttggttt tcttgtattc cccttagtat gcggcgcgcg gcgatgtatg aggaaggtcc 18540 tcctcc ctcc tacgagagtg tggtgagcgc ggcgccagtg gcggcggcgc tgggttctcc 18600 cttcgatgct cccctggacc cgccgtttgt gcctccgcgg tacctgcggc ctaccggggg 18660 gagaaacagc atccgttact ctgagttggc acccctattc gccacaaccc gt gtgtacct 18720 ggtggacaac aagtcaacgg atgtggcatc cctgaactac cagaacgacc acagcaactt 18780 tctgaccacg gtcattcaaa acaatgacta cagcccgggg gaggcaagca cacagaccat 18840 caatcttgac gaccggtcgc actggggcgg cgacctgaaa accatcctgc ataccaacat 18900 gccaaatgg aacgagttca tgtttaccaa taagtttaag gcgcgggtga tggtgtcgcg 18960 cttgcctact aaggacaatc aggtggagct gaaatacgag tgggtggagt tcacgctgcc 19020 cgagggcaac tactccgaga ccatgaccat agaccttatg aacaacgcga tcgtggagca 19080 ctacttgaaa gtgggcagac agaacggggt tctggaaagc gacatcgggg taaagtttga 19140 cacccgcaac ttcagactgg ggtttgaccc cgtcactggt cttgtcatgc ctggggtata 19200 tacaaacgaa gccttccatc cagacatcat tttgctgcca ggatgcgggg tggacttcac 19260 ccacagccgc ctgagcaact tgttgggcat ccgcaagcgg caacccttcc aggagggctt 19320 taggatcacc tacgatgatc tggagggtgg taacattccc gcactgttgg atgtggacgc 19380 ctaccaggcg agcttgaaag atgacaccga acagggcggg ggt ggcgcag gcggcagcaa 19440 cagcagtggc agcggcgcgg aagagaactc caacgcggca gccgcggcaa tgcagccggt 19500 ggaggacatg aacgatcatg ccattcgcgg cgacaccttt gccacacggg ctgaggagaa 19560 gcgcgctgag gccgaagcag cggccgaagc tgccgccccc gctgcgcaac ccgaggtcga 19620 gaagcctcag aagaaaccgg tgatcaaacc cctgacagag gacagcaaga aacgcagtta 19680 caacctaata agcaatgaca gcaccttcac ccagtaccgc agctggtacc ttgcatacaa 19740 ctacggcgac cctcagaccg gaatccgctc atggaccctg ctttgcactc ctgacgtaac 19800 ctgcggctcg gagcaggtct actggtcgtt gccagacatg atgcaagacc ccgtgacctt 19860 ccgctccacg cgccagatca gcaactttcc ggtggtgggc gccgagctgt tgcccgtgca 19920 ctccaagagc ttctacaacg accaggccgt ctactcccaa ctcatccgcc agtttacctc 19980 tctgacccac gtgttcaatc gctttccc ga gaaccagatt ttggcgcgcc cgccagcccc 20040 caccatcacc accgtcagtg aaaacgttcc tgctctcaca gatcacggga cgctaccgct 20100 gcgcaacagc atcggaggag tccagcgagt gaccattact gacgccagac gccgcacctg 20160 cccctacgtt tacaaggccc tgggcatagt ctcgccgcgc gtcctatcga gccgcacttt 20220 ttgagcaagc atgtccatcc ttatatcgcc cagcaataac acaggctggg gcctgcgct t 20280 cccaagcaag atgtttggcg gggccaagaa gcgctccgac caacacccag tgcgcgtgcg 20340 cgggcactac cgcgcgccct ggggcgcgca caaacgcggc cgcactgggc gcaccaccgt 20400 cgatgacgcc atcgacgcgg tggtgg agga ggcgcgcaac tacacgccca cgccgccacc 20460 agtgtccaca gtggacgcgg ccattcagac cgtggtgcgc ggagcccggc gctatgctaa 20520 aatgaagaga cggcggaggc gcgtagcacg tcgccaccgc cgccgacccg gcactgccgc 20580 ccaacgcgcg gcggcggccc tgcttaaccg cgcacgtcgc accggccgac gggcggccat 20640 gcgggccgct cgaaggctgg ccgcgggtat tgtcactgtg cccccccaggt ccaggcg acg 20700 agcggccgcc gcagcagccg cggccattag tgctatgact cagggtcgca ggggcaacgt 20760 gtattgggtg cgcgactcgg ttagcggcct gcgcgtgccc gtgcgcaccc gccccccgcg 20820 caactagatt gcaagaaaa actacttaga ctcgtact gt tgtatgtatc cagcggcggc 20880 ggcgcgcaac gaagctatgt ccaagcgcaa aatcaaagaa gagatgctcc aggtcatcgc 20940 gccggagatc tatggccccc cgaagaagga agagcaggat tacaagcccc gaaagctaaa 21000 gcgggtcaaa aagaaaaaga aagatgatga tgatgaactt gacgacgagg tggaactgct 21060 gcacgctacc gcgcccaggc gacgggtaca gtgggaaaggt cgacgcgtaa aacgtgtttt 21120 gcgaccc ggc accaccgtag tctttacgcc cggtgagcgc tccacccgca cctacaagcg 21180 cgtgtatgat gaggtgtacg gcgacgagga cctgcttgag caggccaacg agcgcctcgg 21240 ggaggtttgcc tacggaaagc ggcataagga catgctggcg ttgccgctgg ac gagggcaa 21300 cccaacacct agcctaaagc ccgtaacact gcagcaggtg ctgcccgcgc ttgcaccgtc 21360 cgaagaaaag cgcggcctaa agcgcgagtc tggtgacttg gcacccaccg tgcagctgat 21420 ggtacccaag cgccagcgac tggaagatgt cttggaaaaa atgaccgtgg aacctgggct 21480 ggagcccgag gtccgcgtgc ggccaatcaa gcaggtggcg ccgggactgg gcgtgcagac 21540 cgtggacgtt caga taccca ctaccagtag caccagtatt gccaccgcca cagagggcat 21600 ggagacacaa acgtccccgg ttgcctcagc ggtggcggat gccgcggtgc aggcggtcgc 21660 tgcggccgcg tccaagacct ctacggaggt gcaaacggac ccgtggatgt ttcgcgttt c 21720 agccccccgg cgcccgcgcc gttcgaggaa gtacggcgcc gccagcgcgc tactgcccga 21780 atatgcccta catccttcca ttgcgcctac ccccggctat cgtggctaca cctaccgccc 21840 cagaagacga gcaactaccc gacgccgaac caccactgga acccgccgcc gccgtcgccg 21900 tcgccagccc gtgctggccc cgatttccgt gcgcagggtg gctcgcgaag gaggcaggac 21960 cctggtgctg ccaacagcgc gctaccaccc c agcatcgtt taaaagccgg tctttgtggt 22020 tcttgcagat atggccctca cctgccgcct ccgtttcccg gtgccgggat tccgaggaag 22080 aatgcaccgt aggaggggca tggccggcca cggcctgacg ggcggcatgc gtcgtgcgca 22140 ccacc ggcgg cggcgcgcgt cgcaccgtcg catgcgcggc ggtatcctgc ccctccttat 22200 tccactgatc gccgcggcga ttggcgccgt gcccggaatt gcatccgtgg ccttgcaggc 22260 gcagagacac tgattaaaaa caagttgcat gtggaaaaat caaaataaaa agtctggact 22320 ctcacgctcg cttggtcctg taactatttt gtagaatgga agacatcaac tttgcgtctc 22380 tggccccgcg acacggctcg cgcccgttca tgggaaactg gcaagatatc ggcaccagca 22440 atatgagcgg tggcgccttc agctggggct cgctgtggag cggcattaaa aatttcggtt 22500 ccaccgttaa gaactatggc agcaaggcct ggaacagcag cacaggccag atgctgaggg 22560 ataagttgaa agag caaaat ttccaacaaa aggtggtaga tggcctggcc tctggcatta 22620 gcggggtggt ggacctggcc aaccaggcag tgcaaaataa gattaacagt aagcttgatc 22680 cccgccctcc cgtagaggag cctccaccgg ccgtggagac agtgtctcca gaggggcgtg 22740 gcgaaaagcg tccgcgcccc gacagggaag aaactctggt gacgcaaata gacgagcctc 22800 cctcgtacga ggaggcacta aagcaaggcc tgcccaccac ccgtcccatc gcg cccatgg 22860 ctaccggagt gctgggccag cacacacccg taacgctgga cctgcctccc cccgccgaca 22920 cccagcagaa acctgtgctg ccaggcccga ccgccgttgt tgtaacccgt cctagccgcg 22980 cgtccctgcg ccgcgccgcc agcggtccgc gatc gttgcg gcccgtagcc agtggcaact 23040 ggcaaagcac actgaacagc atcgtgggtc tgggggtgca atccctgaag cgccgacgat 23100 gcttctgata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 23160 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 23220 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgg gctggtg 23280 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 23340 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 23400 cctgtggacc gtgaggatac tgcgtact cg tacaaggcgc ggttcaccct agctgtgggt 23460 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 23520 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 23580 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 23640 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 23700 gggca ggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 23760 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 23820 cagtggtacg aaacagaaat taatcatgca gctgggagag tcctaaaaaa gactacccca 23880 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 23940 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 24000 actgaggcag ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 24060 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 24120 aactcacgag aactaatggg c caacaatct atgcccaaca ggcctaatta cattgctttt 24180 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 24240 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 24300 taccagcttt tgcttgattc cattggtgat agaaccaggt actttctat gtggaatcag 24360 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 24420 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 24480 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 24540 aatgaaataa gagttggaaa taatt ttgcc atggaaatca atctaaatgc caacctgtgg 24600 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 24660 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 24720 gctcccgg gc tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 24780 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 24840 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 24900 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 24960 aacatggttc tgcagagctc cctagga aat gacctaaggg ttgacggagc cagcattaag 25020 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 25080 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 25140 gcca acatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 25200 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 25260 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 25320 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 25380 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa g gtcagg tggt ggatgatact 25620 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 25680 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 25740 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 25800 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 25860 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 25920 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 25980 cagccgcacc gcggcgt cat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 26040 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 26100 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 26160 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 26220 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaac ccg cactcaaaaa 26280 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 26340 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 26400 cgctggaaaa gtccaccca a agcgtacagg ggcccaactc ggccgcctgt ggactattct 26460 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 26520 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 26580 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 26640 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 2 6700 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 26760 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 26820 catcgctatg cgccactggc agggacacgt tgcgatactg gtgttgtg ctccacttaa 26880 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 26940 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 27000 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 27060 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 27 120 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 27180 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 27240 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 27300 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 27360 cgtgcacgca gcaccttgcg tcggtgttgg agatctg cac cacatttcgg ccccaccggt 27420 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 27480 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 27540 gctcgcct tc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 27600 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 27660 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 27720 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 27780 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcag cctcc atgcccttct 27840 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 27900 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 27960 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 28020 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 28080 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 28140 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 28200 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccg c ttttttgggg 28260 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 28320 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 28380 ccatttcctt ct cctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 28440 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 28500 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 28560 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 28620 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 28680 acctagatgt gggagacgac gt gctgttga agcatctgca gcgccagtgc gccattatct 28740 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 28800 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 28 860 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 28920 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 28980 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 29040 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 29100 aacaggaaa a cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 29160 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 29220 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgcc gtgcgc 29280 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 29340 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 29400 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 29460 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 29520 gctacgtacg ccaggcctgc aagatctcc a acgtggagct ctgcaacctg gtctcctacc 29580 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 29640 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 29700 cgg ccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 29760 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 29820 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 29880 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 29940 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 30000 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 30060 actctgacat aatggaagac gtgagcggtg acggtctact ggaggtgtcac tgtcgctgca 30120 acctatgcac cccgcaccgc tccct ggttt gcaattcgca gctgcttaac gaaagtcaaa 30180 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 30240 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 30300 accacgccca cgagattagg ttctacgaag accaatcccg cccgcctaat gcggagctta 30360 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaa ctg ccgccgc cacccacgga cgaggaggaa 30600 tactggggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 30660 tgggagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 30720 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 30780 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 30840 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 30900 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 30960 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 31020 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 31080 ggcagcggca gcaacagcag cggccacaca gaagcaaagg cgaccggata gcaagactct 31140 gacaaagccc aagaaatcca cagcggcggc agcagcagga ggaggagcgc tgcgtctggc 31200 gcccaacgaa cccgtatcga cccgcgagct tagaaacagg atttttccca ctctgtatgc 31260 tatatt tcaa cagagcaggg gccaagaaca agagctgaaa ataaaaaaca ggtctctgcg 31320 atccctcacc cgcagctgcc tgtatcacaa aagcgaagat cagcttcggc gcacgctgga 31380 agacgcggag gctctcttca gtaaatactg cgcgctgact cttaaggact agtttc gcgc 31440 cctttctcaa atttaagcgc gaaaactacg tcatctccag cggccacacc cggcgccagc 31500 acctgttgtc agcgccatta tgagcaagga aattcccacg ccctacatgt ggagttacca 31560 gccacaaatg ggacttgcgg ctggagctgc ccaagactac tcaacccgaa taaactacat 31620 gagcgcggga ccccacatga tatcccgggt caacggaata cgcgcccacc gaaaccgaat 31680 tctcctggaa caggc ggcta ttaccaccac acctcgtaat aaccttaatc cccgtagttg 31740 gcccgctgcc ctggtgtacc aggaaagtcc cgctcccacc actgtggtac ttcccagaga 31800 cgcccaggcc gaagttcaga tgactaactc aggggcgcag cttgcgggcg gctttcgtca 31860 cagggtgcgg tcgcccgggc agggtataac tcacctgaca atcagagggc gaggtattca 31920 gctcaacgac gagtcggtga gctcctcgct tggtctccgt ccggacggga catttcagat 31980 cggcggcgcc ggccgctctt cattcacgcc tcgtcaggca atcctaactc tgcagacctc 32040 gtcctctgag ccgcgctctg gaggcattgg aactctgcaa tttatgagg agtttgtgcc 32100 atcggtctac tttaaccc ct tctcgggacc tcccggccac tatccggatc aatttattcc 32160 taactttgac gcggtaaagg actcggcgga cggctacgac tgaatgttaa gtggagaggc 32220 agagcaactg cgcctgaaac acctggtcca ctgtcgccgc cacaagtgct ttgcccgcga 3228 0 ctccggtgag ttttgctact ttgaattgcc cgaggatcat atcgagggcc cggcgcacgg 32340 cgtccggctt accgcccagg gagagcttgc ccgtagcctg attcgggagt ttacccagcg 32400 ccccctgcta gttgagcggg acaggggacc ctgtgttctc actgtgattt gcaactgtcc 32460 taaccctgga ttacatcaag atcctctagt taatgtcagg tcgcctaagt cgattaacta 32520 gagtacccgg ggatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 32580 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 32640 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 32700 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 32760 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 32820 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 32880 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 32940 gcgctcaaaa tgggcaacgg cctctctctg g acgaggccg gcaaccttac ctcccaaaat 33000 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 33060 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 33120 gcgggcaaca cactcac cat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 33180 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 33240 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 33300 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 33360 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgacc gta 33420 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 33480 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 33540 tctcaaaaca gacgccttat acttgatgtt agttatccgt tt gatgctca aaaccaacta 33600 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 33660 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 33720 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 33780 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 3 3840 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 33900 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 33960 accggaataa accctccacc taactgtcaa attgtggaaa acactaatac aaatgatggc 34 020 aaacttactt tagtattagt aaaaaatgga gggcttgtta atggctacgt gtctctagtt 34080 ggtgtatcag acactgtgaa ccaaatgttc acacaaaaga cagcaaacat ccaattaaga 34140 ttatattttg actcttctgg aaatctatta actgaggaat cagacttaaa aattccactt 34200 aaaaataaat cttctacagc gaccagtgaa actgtagcca gcagcaaagc ctttatgcca 34260 agtactacag cttat ccctt caacaccact actagggata gtgaaaacta cattcatgga 34320 atatgttact acatgactag ttatgataga agtctatttc ccttgaacat ttctataatg 34380 ctaaacagcc gtatgatttc ttccaatgtt gcctatgcca tacaatttga atggaatcta 34440 aatgcaagtg aatctccaga aagcaacata gctacgctga ccacatcccc ctttttcttt 34500 tcttacatta cagaagacga caactaaaga atcgtttgtg ttatgtttca acgtgtttat 34560 ttttcaattg cagaaaattt caagtcattt ttcattcagt agtatagccc caccaccaca 34620 tagctttatac agatcaccgt accttaatca aactcacaga accctagtat tcaacctgcc 34680 acctccctcc caacacacag agtac acagt cctttctccc cggctggcct taaaaagcat 34740 catatcatgg gtaacagaca tattcttagg tgttatattc cacacggttt cctgtcgagc 34800 caaacgctca tcagtgatat taataaactc cccgggcagc tcacttaagt tcatgtcgct 34860 gtccagctgc tgagccacag gctgctgtcc aacttgcggt tgcttaacgg gcggcgaagg 34920 agaagtccac gcctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg 34980 ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat 35040 ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg 35100 ggcacag cag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac 35160 aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac 35220 agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa 35280 c acgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca 35340 tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac 35400 ctgcccgccg gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca 35460 ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca 35520 cacgtgcata cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccaggg 35580 aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact 35640 cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt 35700 agcgcgggtt tctgtctcaa aag gaggtag acgatcccta ctgtacggag tgcgccgaga 35760 caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt 35820 tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct 35880 tagatcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc 35940 tggcttcggg ttctatgtaa actccttcat gcgcc gctgc cctgataaca tccaccaccg 36000 cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag 36060 cgggaagagc tggaagaacc atgttttttt tttattcca aaagattatc caaaacctca 36120 aaatgaagat ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc 36180 aaagaacaga taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc 36240 ctcacgtcca agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt 36300 ccagcacctt caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta 36360 agcaaatccc gaatattaag tccggccatt gtaaaaatct gctccagagc gccct ccacc 36420 ttcagcctca agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa 36480 gattcaaaag cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca 36540 gctgaacata atcgtgcagg tctgcacgga ccagcgc ggc cacttccccg ccaggaacca 36600 tgacaaaaga acccacactg attatgacac gcatactcgg agctatgcta accagcgtag 36660 ccccgatgta agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat 36720 caggcaaagc ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc 36780 aggtaagctc cggaaccacc acagaaaaag acaccatttt tctctcaaac atgt ctgcgg 36840 gtttctgcat aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct 36900 tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc 36960 gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agct cctcgg tcatgtccgg 37020 agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa 37080 gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc 37140 cataggaggt ataacaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc 37200 ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc 37260 agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac 37320 acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat 37380 aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 37440 aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt 37500 tttcccacgt tacgtcactt cccattttaa gaaaactaca attcccaaca catacaagtt 37560 actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 37620tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg 37678 <210> 23 <211> 34739 <212> DNA <213> artificial sequence <220> <223> #1 vector t ggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gt gttatca tagcgcgtaa tactgtaata gtaatcaatt 360 acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420 ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt 480 cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540 actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600 aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660 acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720 tacatcaatg ggcgtggata gcggtttgac tcac ggggat ttccaagtct ccaccccatt 780 gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840 aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900 agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960 cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020 agacaccggg accgatccag cctccgattt gccaccatgt ttgtgttcct ggtgctgctg 1080 ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc tcctgcctac 1140 accaactcct tcaccaggggg agtctactac cctgacaagg tgt tcaggtc ctctgtgctg 1200 cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt ccatgccatc 1260 catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc attcaatgat 1320 ggaggtctact ttgccagcac agagaagagc aacatcatca ggggctggat ttttggcacc 1380 accctggaca gcaagaccca gtccctgctg attgtgaaca atgccaccaa tgtggt gatt 1440 aaggtgtgg agttccagtt ctgtaatgac ccattcctgg gagtctacta ccacaagaac 1500 aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa ctgtaccttt 1560 gaatatgtga gccaaccatt cctgatggac ttggagggca agcagg gcaa cttcaagaac 1620 ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag caaacacaca 1680 ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc actggtggac 1740 ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca caggtcctac 1800 ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta ctatgtgg gc 1860 tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat cacagatgct 1920 gtggactgg ccctggaccc actgtctgag accaagtgta ccctgaaatc cttcacagtg 1980 gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag cattgt gagg 2040 tttccaaaca tcaccaacct gtgtccattt ggagaggtgt tcaatgccac caggtttgcc 2100 tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta ctctgtgctc 2160 tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac caaactgaat 2220 gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga tgaggtgaga 22 80 cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact gcctgatgac 2340 ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt gggaggcaac 2400 tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga gagggacatc 2460 agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg cttcaactgt 2520 tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta ccaaccatac 2580 agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgg tggaccaaag 2640 aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg actgacaggc 2700 acaggagtgc tgacagagag caacaagaag tcctgccat tccaacagtt tggcagggac 2760 attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct ggacatcaca 2820 ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag caaccaggtg 2880 gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca tgctgaccaa 2940 cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac cagggctggc 3000 tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc aattggagca 3060 ggcatctgg cctcctacca gacccagacc aacagcccaa ggagggcaag gtctgtggca 3120 agccagagca tcattgccta caca atgagt ctgggagcag agaactctgt ggcttacagc 3180 aacaacagca ttgccatccc aaccaacttc accatctctg tgaccacaga gattctgcct 3240 gtgagtatga ccaagacctc tgtggactgt acaatgtata tctgtggaga cagcacagag 3300 tgtagcaacc tgctgctcca atatggctcc ttctgtaccc aacttaacag ggctctgaca 3360 ggcattgctg tggaacagga caagaacacc caggaggtgt ttgcccaggt gaagcagatt 3420 tacaagacac ctccaatcaa ggactttgga ggcttcaact tcagccagat tctgcctgac 3480 ccaagcaagc caagcaagag gtccttcatt gaggacctgc tgttcaacaa ggtgaccctg 3540 gctgatgctg gcttcatcaa gcaatatgga gactgtctgg gagacattgc tgccagggac 3600 ctgatttgtg cccagaagtt caatggactg acagtgctgc ctccactgct gacagatgag 3660 atgattgccc aatacacctc tgccctgctg gctggcacca tcacctctgg ctggaccttt 3720 ggagcaggag cagccctcca aatcccattt gctatgcaga tggcttacag gttcaatggc 3780 attggagtga cccagaatgt gctctatgag aaccagaaac tgattgccaa ccagttcaac 3840 tctgccattg gcaagattca ggactccctg tccagcacag cctctgccct gggcaaactc 3900 caagatgtgg tgaaccagaa tgcccaggct ctgaacaccc tggtgaagca actttccagc 3960 aactttggag ccatctcctc tgtgctgaat gacatcctga gcagactgga caaggtggag 4020 gctgaggtcc agattgacag actgattaca ggcagactcc aatccctcca aacctatggg 4080 acccaacaac ttatcagggc tgctgagatt agggcatctg ccaacctggc tgccaccaag 4140 atgagtgagt gtgtgctggg acaaagcaag agggtggact t ctgtggcaa gggctaccac 4200 ctgatgagtt ttccacagtc tgcccctcat ggaggtggtgt tcctgcatgt gacctatgtg 4260 cctgcccagg agaagaactt caccacagcc cctgccatct gccatgatgg caaggctcac 4320 tttccaaggg agggagtgtt tgtgagcaat ggcacccact ggtttgtgac ccagaggaac 4380 ttctatgaac cacagattat caccacagac aacacctttg tgtctgg caa ctgtgatgtg 4440 gtgattggca ttgtgaacaa cacagtctat gacccactcc aacctgaact ggactccttc 4500 aaggaggaac tggacaaata cttcaagaac cacaccagcc ctgatgtgga cctggggagac 4560 atctctggca tcaatgcctc tgtggtgaac atccagaagg agatt gacag actgaatgag 4620 gtggctaaga acctgaatga gtccctgatt gacctccaag aactgggcaa atatgaacaa 4680 tacatcaagt ggccatgaaa attgatcata atcagccata ccacatttgt agaggtttta 4740 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 4800 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 4860 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 4920 aatgtatctt aacgcggatc tgggcgtggt taagggtggg aaagaatata taaggtgggg 4980 gtcttatgta gttttgtatc tgttttgcag cagccgccgc cgccat gagc accaactcgt 5040 ttgatggaag cattgtgagc tcatatttga caacgcgcat gcccccatgg gccggggtgc 5100 gtcagaatgt gatgggctcc agcattgatg gtcgccccgt cctgcccgca aactctacta 5160 ccttgaccta cgagaccgtg tctggaacgc cgttggagac tgcagcctcc gccgccgctt 5220 cagccgctgc agccaccgcc cgcgggattg tgactgactt tgctttcctg ag cccgcttg 5280 caagcagtgc agcttcccgt tcatccgccc gcgatgacaa gttgacggct cttttggcac 5340 aattggattc tttgacccgg gaacttaatg tcgtttctca gcagctgttg gatctgcgcc 5400 agcaggtttc tgccctgaag gctt cctccc ctcccaatgc ggtttaaaac ataaataaaa 5460 aaccagactc tgtttggatt tggatcaagc aagtgtcttg ctgtctttat ttaggggttt 5520 tgcgcgcgcg gtaggcccgg gaccagcggt ctcggtcgtt gagggtcctg tgtatttttt 5580 ccaggacgtg gtaaaggtga ctctggatgt tcagatacat gggcataagc ccgtctctgg 5640 ggtggaggta gcaccactgc agagcttcat gctgcggggt ggtgttgtag atgatccagt 5700 cgtag cagga gcgctgggcg tggtgcctaa aaatgtcttt cagtagcaag ctgattgcca 5760 ggggcaggcc cttggtgtaa gtgtttacaa agcggttaag ctgggatggg tgcatacgtg 5820 gggatatgag atgcatcttg gactgtattt ttaggttggc tatgttccca gccatatc cc 5880 tccggggatt catgttgtgc agaaccacca gcacagtgta tccggtgcac ttgggaaatt 5940 tgtcatgtag cttagaagga aatgcgtgga agaacttgga gacgcccttg tgacctccaa 6000 gattttccat gcattcgtcc ataatgatgg caatgggccc acgggcggcg gcctgggcga 6060 agatatttct gggatcacta acgtcatagt tgtgttccag gatgagatcg tcataggcca 6120 tttttacaaa gcg cgggcgg agggtgccag actgcggtat aatggttcca tccggcccag 6180 gggcgtagtt accctcacag atttgcattt cccacgcttt gagttcagat ggggggatca 6240 tgtctacctg cggggcgatg aagaaaacgg tttccggggt aggggagatc agctgggaag 63 00 aaagcaggtt cctgagcagc tgcgacttac cgcagccggt gggcccgtaa atcacaccta 6360 ttaccggctg caactggtag ttaagagagc tgcagctgcc gtcatccctg agcagggggg 6420 ccacttcgtt aagcatgtcc ctgactcgca tgttttccct gaccaaatcc gccagaaggc 6480 gctcgccgcc cagcgatagc agttcttgca aggaagcaaa gtttttcaac ggtttgagac 6540 cgtccgccgt aggcatgctt ttgagcgttt gaccaagcag ttccaggcgg tcccacagct 6600 cggtcacctg ctctacggca tctcgatcca gcatatctcc tcgtttcgcg ggttggggcg 6660 gctttcgctg tacggcagta gtcggtgctc gtccagacgg gccagggtca tgtcttt cca 6720 cgggcgcagg gtcctcgtca gcgtagtctg ggtcacggtg aaggggtgcg ctccgggctg 6780 cgcgctggcc agggtgcgct tgaggctggt cctgctggtg ctgaagcgct gccggtcttc 6840 gccctgcgcg tcggccaggt agcatttgac catggtgtca tagtccagcc cctccgcggc 6900 gtggcccttg gcgcgcagct tgcccttgga ggaggcgccg cacgaggggc agtgcagact 6960 tttgagggcg tagagcttgg gcgcg agaaa taccgattcc ggggagtagg catccgcgcc 7020 gcaggccccg cagacggtct cgcattccac gagccaggtg agctctggcc gttcggggtc 7080 aaaaaccagg tttcccccat gctttttgat gcgtttctta cctctggttt ccatgagccg 7140 gtgtccacgc tcggtgacga aaaggctgtc cgtgtccccg tatacagact tgagaggcct 7200 gtcctcgagc ggtgttccgc ggtcctcctc gtatagaaac tcggaccact ctgagacaaa 7260 ggctcgcgtc caggccagca cgaaggaggc taagtgggag gggtagcggt cgttgtccac 7320 tagggggtcc actcgctcca gggtgtgaag acacatgtcg ccctcttcgg catcaaggaa 7380 ggtgattggt ttgtaggtgt aggccacgtg accgggtgtt cctgaagggg ggct ataaaa 7440 gggggtgggg gcgcgttcgt cctcactctc ttccgcatcg ctgtctgcga gggccagctg 7500 ttggggtgag tactccctct gaaaagcggg catgacttct gcgctaagat tgtcagtttc 7560 caaaaacgag gaggatttga tattcacctg gcccgcggtg atgcctttga gggtggccgc 7620 atccatctgg tcagaaaaga caatcttttt gttgtcaagc ttggtggcaa acgacccgta 7680 gagggcgttg gacagcaact tggcgatgga gcgcagggtt tggtttttgt cgcgatcggc 7740 gcgctccttg gccgcgatgt ttagctgcac gtattcgcgc gcaacgcacc gccattcggg 7800 aaagacggtg gtgcgctcgt cgggcaccag gtgcac gcgc caaccgcggt tgtgcagggt 7860 gacaaggtca acgctggtgg ctacctctcc gcgtaggcgc tcgttggtcc agcagaggcg 7920 gccgcccttg cgcgagcaga atggcggtag ggggtctagc tgcgtctcgt ccggggggtc 7980 tgcgtccacg gtaaagaccc cgggcagcag gcgcgcgtcg aagtagtcta tcttgcatcc 8040 ttgcaagtct agcgcctgct gccatgcgcg ggcggcaagc gcgcgctcgt atgggttgag 8100 tggggggaccc catggcatgg ggtgggtgag cgcggaggcg tacatgccgc aaatgtcgta 8160 aacgtagagg ggctctctga gtattccaag atatgtaggg tagcatcttc caccgcggat 8220 gctggcgcgc acgtaatcgt atagttcgtg cgagggagcg aggaggtcgg gaccgaggtt 8280 gctacgggcg ggctgctctg ctcggaagac tatctgcctg aagatggcat gtgagttgga 8340 tgatatggtt ggacgctgga agacgttgaa gctggcgtct gtgagaccta ccgcgtcacg 8400 cacgaaggag gcgtaggagt cgcgcagctt gttgaccagc tcgg cggtga cctgcacgtc 8460 tagggcgcag tagtccaggg tttccttgat gatgtcatac ttatcctgtc cctttttttt 8520 ccacagctcg cggttgagga caaactcttc gcggtctttc cagtactctt ggatcggaaa 8580 cccgtcggcc tccgaacggt aagagcctag catgtagaac tggttgacgg cctggtaggc 8640 gcagcatccc tttctacgg gtagcgcgta tgcctgcgcg gccttccgga gcgaggtgtg 8 700 ggtgagcgca aaggtgtccc tgaccatgac tttgaggtac tggtatttga agtcagtgtc 8760 gtcgcatccg ccctgctccc agagcaaaaa gtccgtgcgc ttttggaac gcggatttgg 8820 cagggcgaag gtgacatcgt tgaagagtat ctttc ccgcg cgaggcataa agttgcgtgt 8880 gatgcggaag ggtcccggca cctcggaacg gttgttaatt acctgggcgg cgagcacgat 8940 ctcgtcaaag ccgttgatgt tgtggcccac aatgtaaagt tccaagaagc gcgggatgcc 9000 cttgatggaa ggcaattttt taagttcctc gtaggtgagc tcttcagggg agctgagccc 9060 gtgctctgaa agggcccagt ctgcaagatg agggttggaa gcgacgaatg agctccacag 9120 gtcac gggcc attagcattt gcaggtggtc gcgaaaggtc ctaaactggc gacctatggc 9180 cattttttct ggggtgatgc agtagaaggt aagcgggtct tgttcccagc ggtcccatcc 9240 aaggttcgcg gctaggtctc gcgcggcagt cactagaggc tcatctccgc cgaacttcat 9300 gaccagcatg aagggcacga gctgcttccc aaaggccccc atccaagtat aggtctctac 9360 atcgtaggtg acaaagagac gctcggtgcg aggatgcgag ccgatcggga agaactggat 9420 ctcccgccac caattggagg agtggctatt gatgtggtga aagtagaagt ccctgcgacg 9480 ggccgaacac tcgtgctggc ttttgtaaaa acgtgcgcag tactggcagc ggtgcacggg 9540 ctgtacatcc tgcac gaggt tgacctgacg accgcgcaca aggaagcaga gtgggaattt 9600 gagcccctcg cctggcgggt ttggctggtg gtcttctact tcggctgctt gtccttgacc 9660 gtctggctgc tcgaggggag ttacggtgga tcggaccacc acgccgcgcg agcccaaag t 9720 ccagatgtcc gcgcgcggcg gtcggagctt gatgacaaca tcgcgcagat gggagctgtc 9780 catggtctgg agctcccgcg gcgtcaggtc aggcgggagc tcctgcaggt ttacctcgca 9840 tagacgggtc agggcgcggg ctagatccag gtgataccta atttccaggg gctggttggt 9900 ggcggcgtcg atggcttgca agaggccgca tccccgcggc gcgactacgg taccgcgcgg 9960 cgggcggtgg gccgcggggg tgtccttgga tgatgcatct aaaagcggtg acgcgggcga 10020 gcccccggag gtaggggggg ctccggaccc gccgggagag ggggcagggg cacgtcggcg 10080 ccgcgcgcgg gcaggagctg gtgctgcgcg cgtaggttgc tggcgaacgc gacgacgcgg 10140 c ggttgatct cctgaatctg gcgcctctgc gtgaagacga cgggcccggt gagcttgaac 10200 ctgaaagaga gttcgacaga atcaatttcg gtgtcgttga cggcggcctg gcgcaaaatc 10260 tcctgcacgt ctcctgagtt gtcttgatag gcgatctcgg ccatgaactg ctcgatctct 10320 tcctcctgga gatctccgcg tccggctcgc tccacggtgg cggcgaggtc gttggaaatg 10380 cgggccatga gctgcgagaa ggcgttga gg cctccctcgt tccagacgcg gctgtagacc 10440 acgccccctt cggcatcgcg ggcgcgcatg accacctgcg cgagattgag ctccacgtgc 10500 cgggcgaaga cggcgtagtt tcgcaggcgc tgaaagaggt agttgagggt ggtggcggtg 10560 t gttctgcca cgaagaagta cataacccag cgtcgcaacg tggattcgtt gatatccccc 10620 aaggcctcaa ggcgctccat ggcctcgtag aagtccacgg cgaagttgaa aaactgggag 10680 ttgcgcgccg acacggttaa ctcctcctcc agaagacgga tgagctcggc gacagtgtcg 10740 cgcacctcgc gctcaaaggc tacaggggcc tcttcttctt cttcaatctc ctcttccata 10800 agggcctccc cttcttcttc ttctggcggc ggtgg gggag gggggacacg gcggcgacga 10860 cggcgcaccg ggaggcggtc gacaaagcgc tcgatcatct ccccgcggcg acggcgcatg 10920 gtctcggtga cggcgcggcc gttctcgcgg gggcgcagtt ggaagacgcc gcccgtcatg 10980 tcccggtta t gggttggcgg ggggctgcca tgcggcaggg atacggcgct aacgatgcat 11040 ctcaacaatt gttgtgtagg tactccgccg ccgagggacc tgagcgagtc cgcatcgacc 11100 ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg taggctgagc 11160 accgtggcgg gcggcagcgg gcggcggtcg gggttgtttc tggcggaggt gctgctgatg 11220 atgtaattaa agtaggcggt cttgagacgg cggatggtcg acagaagcac catgtcct tg 11280 ggtccggcct gctgaatgcg caggcggtcg gccatgcccc aggcttcgtt ttgacatcgg 11340 cgcaggtctt tgtagtagtc ttgcatgagc ctttctaccg gcacttcttc ttctccttcc 11400 tcttgtcctg catctcttgc atct atcgct gcggcggcgg cggagtttgg ccgtaggtgg 11460 cgccctcttc ctcccatgcg tgtgaccccg aagcccctca tcggctgaag cagggctagg 11520 tcggcgacaa cgcgctcggc taatatggcc tgctgcacct gcgtgagggt agactggaag 11580 tcatccatgt ccacaaagcg gtggtatgcg cccgtgttga tggtgtaagt gcagttggcc 11640 ataacggacc agttaacggt ctggtgaccc ggctgcgaga gctcggtgta cctgagacgc 117 00 gagtaagccc tcgagtcaaa tacgtagtcg ttgcaagtcc gcaccaggta ctggtatccc 11760 accaaaaagt gcggcggcgg ctggcggtag aggggccagc gtagggtggc cggggctccg 11820 ggggcgagat cttccaacat aaggcgatga tatccgtaga tgt acctgga catccaggtg 11880 atgccggcgg cggtggtgga ggcgcgcgga aagtcgcgga cgcggttcca gatgttgcgc 11940 agcggcaaaa agtgctccat ggtcgggacg ctctggccgg tcaggcgcgc gcaatcgttg 12000 acgctctagc gtgcaaaagg agagcctgta agcgggcact cttccgtggt ctggtggata 12060 aattcgcaag ggtatcatgg cggacgaccg gggttcgagc cccgtatccg gccgtccgcc 12120 gtga tccatg cggttaccgc ccgcgtgtcg aacccaggtg tgcgacgtca gacaacgggg 12180 gagtgctcct tttggcttcc ttccaggcgc ggcggctgct gcgctagctt ttttggccac 12240 tggccgcgcg cagcgtaagc ggttaggctg gaaagcga aa gcattaagtg gctcgctccc 12300 tgtagccgga gggttatttt ccaagggttg agtcgcggga cccccggttc gagtctcgga 12360 ccggccggac tgcggcgaac gggggtttgc ctccccgtca tgcaagaccc cgcttgcaaa 12420 ttcctccgga aacagggacg agcccctttt ttgcttttcc cagatgcatc cggtgctgcg 12480 gcagatgcgc ccccctcctc agcagcggca agagcaagag cagcggcaga catgcagggc 12540 accctcccc t cctcctaccg cgtcaggagg ggcgacatcc gcggttgacg cggcagcaga 12600 tggtgattac gaacccccgc ggcgccgggc ccggcactac ctggacttgg aggagggcga 12660 gggcctggcg cggctaggag cgccctctcc tgagcggcac ccaagggtgc agctga agcg 12720 tgatacgcgt gaggcgtacg tgccgcggca gaacctgttt cgcgaccgcg agggagga 12780 gcccgaggag atgcgggatc gaaagttcca cgcagggcgc gagctgcggc atggcctgaa 12840 tcgcgagcgg ttgctgcgcg aggaggactt tgagcccgac gcgcgaaccg ggattagtcc 12900 cgcgcgcgca cacgtggcgg ccgccgacct ggtaaccgca tacgagcaga cggtgaacca 12960 ggagattaac tttca aaaaa gctttaacaa ccacgtgcgt acgcttgtgg cgcgcgagga 13020 ggtggctata ggactgatgc atctgtggga ctttgtaagc gcgctggagc aaaacccaaa 13080 tagcaagccg ctcatggcgc agctgttcct tatagtgcag cacagcaggg acaacgaggc 1 3140 attcagggat gcgctgctaa acatagtaga gcccgagggc cgctggctgc tcgatttgat 13200 aaacatcctg cagagcatag tggtgcagga gcgcagcttg agcctggctg acaaggtggc a acgagcgca tccacaaggc 13440 cgtgagcgtg agccggcggc gcgagctcag cgaccgcgag ctgatgcaca gcctgcaaag 13500 ggccctggct ggcacgggca gcggcgatag agaggccgag tcctactttg acgcgggcgc 13560 tgacctgcgc tgggccccaa gccgacgcgc cctggaggca gctggggccg gacctgggct 13620 ggcggtggca cccgcgcgcg ctggcaacgt cggcggcgtg gaggaatatg acgaggacga 13680 tgagtacgag ccagaggacg gcgagtacta agcggtgatg tttctgatca gatgatgcaa 13740 gacgcaacgg acccggcggt gcgggcggcg ctgcagagcc agccgtccgg ccttaactcc 13800 acggacgact ggcgccaggt catggaccgc atcatgtcgc tgactgc gcg caatcctgac 13860 gcgttccggc agcagccgca ggccaaccgg ctctccgcaa ttctggaagc ggtggtcccg 13920 gcgcgcgcaa accccacgca cgagaaggtg ctggcgatcg taaacgcgct ggccgaaaac 13980 agggccatcc ggc ccgacga ggccggcctg gtctacgacg cgctgcttca gcgcgtggct 14040 cgttacaaca gcggcaacgt gcagaccaac ctggaccggc tggtggggga tgtgcgcgag 14100 gccgtggcgc agcgtgagcg cgcgcagcag cagggcaacc tgggctccat ggttgcacta 14160 aacgccttcc tgagtacaca gcccgccaac gtgccgcggg gacaggagga ctacaccaac 14220 tttgtgagcg cactgcggct aatggtgact gagacaccgc aaagtgaggt gtaccagtct 14280 gggccagact attttttcca gaccagtaga caaggcctgc agaccgtaaa cctgagccag 14340 gctttcaaaa acttgcaggg gctgtggggg gtgcgggctc ccacaggcga ccgcgcgacc 14400 gtgtctagct tgctgacgcc caactc gcgc ctgttgctgc tgctaatagc gcccttcacg 14460 gacagtggca gcgtgtcccg ggacacatac ctaggtcact tgctgacact gtaccgcgag 14520 gccataggtc aggcgcatgt ggacgagcat actttccagg agattacaag tgtcagccgc 14580 gcgctggggc aggaggacac gggcagcctg gaggcaaccc taaactacct gctgaccaac 14640 cggcggcaga agatcccctc gttgcacagt ttaaacagcg aggagggagcg cattttgcgc 14700 tacgtgcagc agagcgtgag ccttaacctg atgcgcgacg gggtaacgcc cagcgtggcg 14760 ctggacatga ccgcgcgcaa catggaaccg ggcatgtatg cctcaaaccg gccgtttatc 14820 aaccgcctaa tggactactt gcatcgcgcg gccgccgtga accccga gta tttcaccaat 14880 gccatcttga acccgcactg gctaccgccc cctggtttct acaccggggg attcgaggtg 14940 cccgagggta acgatggatt cctctgggac gacatagacg acagcgtgtt ttccccgcaa 15000 ccgcagaccc tgctagagtt gcaacagcgc gagcaggcag aggcggcgct gcgaaaggaa 15060 agcttccgca ggccaagcag cttgtccgat ctaggcgctg cggccccgcg gtcagatgct 15120 ag tagcccat ttccaagctt gatagggtct cttaccagca ctcgcaccac ccgcccgcgc 15180 ctgctgggcg aggaggagta cctaaacaac tcgctgctgc agccgcagcg cgaaaaaaac 15240 ctgcctccgg catttcccaa caacgggata gagagcctag tggaca agat gagtagatgg 15300 aagacgtacg cgcaggagca cagggacgtg ccaggcccgc gcccgcccac ccgtcgtcaa 15360 aggcacgacc gtcagcgggg tctggtgtgg gaggacgatg actcggcaga cgacagcagc 15420 gtcctggatt tgggagggag tggcaacccg tttgcgcacc ttcgccccag gctggggaga 15480 atgttttaaa aaaaaaaaag catgatgcaa aataaaaaac tcaccaaggc catggcaccg 15540 agcgttggtt ttcttgtatt ccccttagta tgcggcgcgc ggcgatgtat gaggaaggtc 15600 ctcctccctc ctacgagagt gtggtgagcg cggcgccagt ggcggcggcg ctgggttctc 15660 ccttcgatgc tcccctggac ccgccgtttg tgcctccgcg gt acctgcgg cctaccgggg 15720 ggagaaacag catccgttac tctgagttgg cacccctatt cgacaccacc cgtgtgtacc 15780 tggtggacaa caagtcaacg gatgtggcat ccctgaacta ccagaacgac cacagcaact 15840 ttctgaccac ggtcattcaa aacaatgact acagcccggg ggaggcaagc acacagacca 15900 tcaatcttga cgaccggtcg cactggggcg gcgacctgaa aaccatcctg cataccaaca 15960 tgccaaatgt gaacgagttc atgtttacca ataagtttaa ggcgcgggtg atggtgtcgc 16020 gcttgcctac taaggacaat caggtggagc tgaaatacga gtgggtggag ttcacgctgc 16080 ccgagggcaa ctactccgag accatgacca tagaccttat gaacaacgcg atcgtggagc 16140 acttgaa agtgggcaga caga acgggg ttctggaaag cgacatcggg gtaaagtttg 16200 acacccgcaa cttcagactg gggtttgacc ccgtcactgg tcttgtcatg cctggggtat 16260 atacaaacga agccttccat ccagacatca ttttgctgcc aggatgcggg gtggacttca 16320 cccacagccg cctgagcaac ttgttgggca tccgcaagcg gcaacccttc caggagggct 16380 ttaggatcac ctacgatgat ctggagggtg gtaacatt cc cgcactgttg gatgtggacg 16440 cctaccaggc gagcttgaaa gatgacaccg aacagggcgg gggtggcgca ggcggcagca 16500 acagcagtgg cagcggcgcg gaagagaact ccaacgcggc agccgcggca atgcagccgg 16560 tggaggacat gaacgatcat gcc attcgcg gcgacacctt tgccacacgg gctgaggaga 16620 agcgcgctga ggccgaagca gcggccgaag ctgccgcccc cgctgcgcaa cccgaggtcg 16680 agaagcctca gaagaaaccg gtgatcaaac ccctgacaga ggacagcaag aaacgcagtt 16740 acaacctaat aagcaatgac agcaccttca cccagtaccg cagctggtac cttgcataca 16800 actacggcga ccctcagacc ggaatccgct catggaccct gctttgcact cctgacg taa 16860 cctgcggctc ggagcaggtc tactggtcgt tgccagacat gatgcaagac cccgtgacct 16920 tccgctccac gcgccagatc agcaactttc cggtggtggg cgccgagctg ttgcccgtgc 16980 actccaagag cttctacaac gaccaggccg tct actccca actcatccgc cagtttacct 17040 ctctgaccca cgtgttcaat cgctttcccg agaaccagat tttggcgcgc ccgccagccc 17100 ccaccatcac a gccgcactt 17280 tttgagcaag catgtccatc cttatatcgc ccagcaataa cacaggctgg ggcctgcgct 17340 tcccaagcaa gatgtttggc ggggccaaga agcgctccga ccaacaccca gtgcgcgtgc 17400 gcgggcacta ccgcgcgccc tgg ggcgcgc acaaacgcgg ccgcactggg cgcaccaccg 17460 tcgatgacgc catcgacgcg gtggtggagg aggcgcgcaa ctacacgccc acgccgccac 17520 cagtgtccac agtggacgcg gccattcaga ccgtggtgcg cggagcccgg cgctatgcta 17580 aaatgaagag acggcggagg cgcgtagcac gtcgccaccg ccgccgaccc ggcactgccg 17640 cccaacgcgc ggcggcggcc ctgcttaacc gcgcacgtcg caccggccga cgggcggcca 17700 tgcgggccgc tcgaaggctg gccgcgggta ttgtcactgt gccccccagg tccaggcgac 17760 gagcggccgc cgcagcagcc gcggccatta gtgctatgac tcagggtcgc aggggcaacg 17820 tgtattgggt gcgcgactcg gttagcgg cc tgcgcgtgcc cgtgcgcacc cgccccccgc 17880 gcaactagat tgcaagaaaa aactacttag actcgtactg ttgtatgtat ccagcggcgg 17940 cggcgcgcaa cgaagctatg tccaagcgca aaatcaaaga agagatgctc caggtcatcg 18000 cgccggagat ctatggcccc ccgaagaagg aagagcagga ttacaagccc cgaaagctaa 18060 agcgggtcaa aaagaaaaag aaagatgatg atgatgaact tgacgacgag gtggaactgc 18120 tgcacg ctac cgcgcccagg cgacgggtac agtggaaagg tcgacgcgta aaacgtgttt 18180 tgcgacccgg caccaccgta gtctttacgc ccggtgagcg ctccacccgc acctacaagc 18240 gcgtgtatga tgaggtgtac ggcgacgagg acctgcttga gcagccaac gagcgcctcg 18300 gggagtttgc ctacggaaag cggcataagg acatgctggc gttgccgctg gacgagggca 18360 acccaacacc tagcctaaag cccgtaacac tgcagcaggt gctgcccgcg cttgcaccgt 18420 ccgaagaaaa gcgcggccta aagcgcgagt ctggtgactt ggcacccacc gtgcagctga 18480 tggtacccaa gcgccagcga ctggaagatg tcttggaaaa aatgaccgtg gaacctgggc 18540 taggagcc ca ggcggtcg 18720 ctgcggccgc gtccaagacc tctacggagg tgcaaacgga cccgtggatg tttcgcgttt 18780 cagccccccg gcgcccgcgc cgttcgagga agtacggcgc cgccagcgcg ctactgcccg 18840 aatatgccct acatccttcc attgcgccta cccccggcta tcgtggctac acctaccgcc 18900 ccagaagacg agcaactacc cgacgccgaa ccaccactgg aacccgccgc cgccgtcgcc 18960 gtcgccagcc cgtgctggcc ccgatttccg t gcgcagggt ggctcgcgaa ggaggcagga 19020 ccctggtgct gccaacagcg cgctaccacc ccagcatcgt ttaaaagccg gtctttgtgg 19080 ttcttgcaga tatggccctc acctgccgcc tccgtttccc ggtgccggga ttccgaggaa 19140 ga atgcaccg taggaggggc atggccggcc acggcctgac gggcggcatg cgtcgtgcgc 19200 accaccggcg gcggcgcgcg tcgcaccgtc gcatgcgcgg cggtatcctg cccctcctta gta actattt tgtagaatgg aagacatcaa ctttgcgtct 19440 ctggccccgc gacacggctc gcgcccgttc atgggaaact ggcaagatat cggcaccagc 19500 aatatgagcg gtggcgcctt cagctggggc tcgctgtgga gcggcattaa aaatttcggt 19560 tcc accgtta agaactatgg cagcaaggcc tggaacagca gcacaggcca gatgctgagg 19620 gataagttga aagagcaaaa tttccaacaa aaggtggtag atggcctggc ctctggcatt 19680 agcggggtgg tggacctggc caaccaggca gtgcaaaata agattaacag taagcttgat 19740 ccccgccctc ccgtagagga gcctccaccg gccgtggaga cagtgtctcc agaggggcgt 19800 ggcgaaaagc gtccgcgccc cgacagggaa gaaactctgg tgacgcaa at agacgagcct 19860 ccctcgtacg aggaggcact aaagcaaggc ctgccacca cccgtcccat cgcgcccatg 19920 gctaccggag tgctgggcca gcacacaccc gtaacgctgg acctgcctcc ccccgccgac 19980 acccagcaga aacctgtgct gccaggcccg acc gccgttg ttgtaacccg tcctagccgc 20040 gcgtccctgc gccgcgccgc cagcggtccg cgatcgttgc ggcccgtagc cagtggcaac 20100 tggcaaagca cactgaacag catcgtgggt ctgggggtgc aatccctgaa gcgccgacga 20160 tgcttctgat agctaacgtg tcgtatgtgt gtcatgtatg cgtccatgtc gccgccagag 20220 gagctgctga gccgccgcgc gcccgctttc caagatggct accccttcga tgatgcc gca 20280 gtggtcttac atgcacatct cgggccagga cgcctcggag tacctgagcc ccgggctggt 20340 gcagtttgcc cgcgccaccg agacgtactt cagcctgaat aacaagttta gaaaccccac 20400 ggtggcgcct acgcacgacg tgaccacaga ccggtcc cag cgtttgacgc tgcggttcat 20460 ccctgtggac cgtgaggata ctgcgtactc gtacaaggcg cggttcaccc tagctgtggg 20520 tgataaccgt gtgctggaca tggcttccac gtactttgac atccgcggcg tgctggacag 20580 gggccctact tttaagccct actctggcac tgcctacaac gccctggctc ccaagggtgc 20640 cccaaatcct tgcgaatggg atgaagctgc tactgctctt gaaataaacc tagaagaaga 20700 ggacgatgac aacgaagacg aagtagacga gcaagctgag cagcaaaaaa ctcacgtatt 20760 tgggcaggcg ccttattctg gtataaatat tacaaaggag ggtattcaaa taggtgtcga 20820 aggtcaaaca cctaaatatg ccgataaaac atttcaacct gaacctcaaa taggaga atc 20880 tcagtggtac gaaacagaaa ttaatcatgc agctgggaga gtcctaaaaa agactacccc 20940 aatgaaacca tgttacggtt catatgcaaa acccacaaat gaaaatggag ggcaaggcat 21000 tcttgtaaag caacaaaatg gaaagctaga aagtcaagtg gaaatgcaat ttttctcaac 21060 tactgaggca gccgcaggca atggtgataa cttgactcct aaagtggtat tgtacagtga 21120 agatgtaga t atagaaaccc cagacactca tatttcttac atgcccacta ttaaggaagg 21180 taactcacga gaactaatgg gccaacaatc tatgcccaac aggcctaatt acattgcttt 21240 tagggacaat tttattggtc taatgtatta caacagcacg ggtaatatgg gtgttctggc 21300 ggccca agca tcgcagttga atgctgttgt agatttgcaa gacagaaaca cagagctttc 21360 ataccagctt ttgcttgatt ccattggtga tagaaccagg tacttttcta tgtggaatca 21420 ggctgttgac agctatgatc cagatgttag aattattgaa aatcatggaa ctgaagatga 21480 acttccaaat tactgctttc cactgggagg tgtgattaat acagagactc ttaccaaggt 21540 aaaacctaaa acaggtcagg aaa atggatg ggaaaaagat gctacagaat tttcagataa 21600 aaatgaaata agagttggaa ataattttgc catggaaatc aatctaaatg ccaacctgtg 21660 gagaaatttc ctgtactcca acatagcgct gtatttgccc gacaagctaa agtacagtcc 21720 ttccaac gta aaaatttctg ataacccaaa cacctacgac tacatgaaca agcgagtggt 21780 ggctcccggg ctagtggact gctacattaa ccttggagca cgctggtccc ttgactatat 21840 ggacaacgtc aacccattta accaccaccg caatgctggc ctgcgctacc gctcaatgtt 21900 gctgggcaat ggtcgctatg tgcccttcca catccaggtg cctcagaagt tctttgccat 21960 taaaaacctc cttctcctgc cgggct cata cacctacgag tggaacttca ggaaggatgt 22020 taacatggtt ctgcagagct ccctaggaaa tgacctaagg gttgacggag ccagcattaa 22080 gtttgatagc atttgccttt acgccacctt cttccccatg gcccacaaca ccgcctccac 22140 gcttgaggcc atgcttagaa acgacaccaa cgaccagtcc tttaacgact atctctccgc 22200 cgccaacatg ctctacccta tacccgccaa cgctaccaac gtgcccatat ccatcccctc 22260 ccgcaactgg gcggctttcc gcggctgggc cttcacgcgc cttaagacta aggaaacccc 22320 atcactgggc tcgggctacg acccttatta cacctactct ggctctatac cctacctaga 22380 tggaaccttt tacctcaacc acacctttaa gaaggtggcc attacc tttg actcttctgt 22440 cagctggcct ggcaatgacc gcctgcttac ccccaacgag tttgaaatta agcgctcagt 22500 tgacggggag ggttacaacg ttgcccagtg taacatgacc aaagactggt tcctggtaca 22560 aatgctagct aactataaca ttggctacca gggcttctat atcccagaga gctacaagga 22620 ccgcatgtac tccttcttta gaaacttcca gcccatgagc cgtcaggtgg tggatgatac 22680 taaatacaag gactaccaac aggtgggcat cctacaccaa cacaacaact ctggatttgt 22740 tggctacctt gccccaccca tgcgcgaagg acaggcctac cctgctaact tcccctatcc 22800 gcttataggc aagaccgcag ttgacagcat tacccagaaa aagtttcttt gcgat gttt gaagtc tttgacgtgg tccgtgtgca 23040 ccagccgcac cgcggcgtca tcgaaaccgt gtacctgcgc acgcccttct cggccggcaa 23100 cgccacaaca taaagaagca agcaacatca acaacagctg ccgccatggg ctccagtgag 23160 caggaactga aagccattgt caaagatctt ggttgtgggc catatttttt gggcacctat 23220 gacaagcgct ttccaggctt tgtttctcca cacaagctcg cctgcgccat agtcaatacg 23280 gccggtcgcg agactggggg cgtacactgg atggcctttg cctggaaccc gcactcaaaa 23340 acatgctacc tctttgagcc ctttggcttt tctgaccagc gactcaagca ggtttaccag 23400 tttgagtacg agtcactcct gcgccgtagc gccattgctt cttcccccga ccgctgtata 23460 acgctggaaa agtccaccca aagcgtacag gggcccaact cggccgcctg tggactattc 23520 tgctgcatgt ttctccacgc cg cagccaca gtgcgcagat taggagcgcc acttcttttt gtcacttgaa aaacatgtaa 23760 aaataatgta ctagagacac tttcaataaa ggcaaatgct tttattgta cactctcggg 23820 tgattattta cccccaccct tgccgtctgc gccgtttaaa aatcaaaggg gttctgccgc 23880 gcatcgctat gcgccactgg cagggacacg ttgcgatact ggtgtttagt gctccactta 23940 aactcaggca caaccatccg cggcagctcg gtgaagtttt cactccacag gctgcgcacc 24000 atcaccaacg cgtttagcag gtcgggcgcc gatatcttga agtcgcagtt ggggcctccg 24060 ccctgcgcgc gcgagttgcg atacacaggg ttgcagcact ggaacactat cagcgccggg 24120 t ggtgcacgc tggccagcac gctcttgtcg gagatcagat ccgcgtccag gtcctccgcg 24180 ttgctcaggg cgaacggagt caactttggt agctgccttc ccaaaaaggg cgcgtgccca 24240 ggctttgagt tgcactcgca ccgtagtggc atcaaa aggt gaccgtgccc ggtctgggcg 24300 ttaggataca gcgcctgcat aaaagccttg atctgcttaa aagccacctg agcctttgcg 24360 ccttcagaga agaacatgcc gcaagacttg ccggaaaact gattggccgg acaggccgcg 24420 tcgtgcacgc agcaccttgc gtcggtgttg gagatctgca ccacatttcg gccccaccgg 24480 ttcttcacga tcttggcctt gctagactgc tccttcagcg cgcgctgccc gttttcgctc 24540 gtcacatcca tttcaatcac gtgctcctta tttatcataa tgcttccgtg tagacactta 24600 agctcgcctt cgatctcagc gcagcggtgc agccacaacg cgcagcccgt gggctcgtga 24660 tgcttgtagg tcacctctgc aaacgactgc aggtacgcct g caggaatcg ccccatcatc 24720 gtcacaaagg tcttgttgct ggtgaaggtc agctgcaacc cgcggtgctc ctcgttcagc 24780 caggtcttgc atacggccgc cagagcttcc acttggtcag gcagtagttt gaagttcgcc 24840 tttagatcgt tatccacgtg gtacttgtcc atcagcgcgc gcgcagcctc catgcccttc 24900 tcccacgcag acacgatcgg cacactcagc gggttcatca ccgtaatttc actttccgct 24960 tcgctgggct cttcctcttc ctcttgcgtc cgcataccac gcgccactgg gtcgtcttca 25020 ttcagccgcc gcactgtgcg cttacctcct ttgccatgct tgattagcac cggtgggttg 25080 ctgaaaccca ccatttgtag cgccacatct tctctttctt cctcgctgtc cacgattacc 25 140 tctggtgatg gcgggcgctc gggcttggga gaagggcgct tctttttctt cttgggcgca 25200 atggccaaat ccgccgccga ggtcgatggc cgcgggctgg gtgtgcgcgg caccagcgcg 25260 tcttgtgatg agtcttcctc gtcctcggac tcgatacgcc gcctcatccg cttttttggg 25320 ggcgcccggg gaggcggcgg cgacggggac ggggacgaca cgtcctccat ggttggggga 25380 cgtcgcgccg caccgcgtcc gcgct cgggg gtggtttcgc gctgctcctc ttcccgactg 25440 gccatttcct tctcctatag gcagaaaaag atcatggagt cagtcgagaa gaaggacagc 25500 ctaaccgccc cctctgagtt cgccaccacc gcctccaccg atgccgccaa cgcgcctacc 25560 accttccccg tcgaggcacc cccgcttgag gaggaggaag tgattatcga gcaggaccca 25620 ggttttgtaa gcgaagacga cgaggaccgc tcagtaccaa cagaggataa aaagcaagac 25680 caggacaacg cagaggcaaa cgaggaacaa gtcgggcggg gggacgaaag gcatggcgac 25740 tacctagatg tgggagacga cgtgctgttg aagcatctgc agcgccagtg cgccattatc 25800 tgcgacgcgt tgcaagagcg cagcgatgtg cccctcgcca tagc ggatgt cagccttgcc 25860 tacgaacgcc acctattctc accgcgcgta ccccccaaac gccaagaaaa cggcacatgc 25920 gagcccaacc cgcgcctcaa cttctacccc gtatttgccg tgccagaggt gcttgccacc 25980 tatcacatct ttttccaaaa ctgcaagata cccctatcct gccgtgccaa ccgcagccga 26040 gcggacaagc agctggcctt gcggcagggc gctgtcatac ctgatatcgc ctcgctcaac 26100 gaagtgccaa aaatctttga gggtcttgga cgcgacgaga agcgcgcggc aaacgctctg 26160 caacaggaaa acagcgaaaa tgaaagtcac tctggagtgt tggtggaact cgagggtgac 26220 aacgcgcgcc tagccgtact aaaacgcagc atcgaggtca cccacttt gc ctacccggca 26280 cttaacctac cccccaaggt catgagcaca gtcatgagtg agctgatcgt gcgccgtgcg 26340 cagcccctgg agagggatgc aaatttgcaa gaacaaacag aggagggcct acccgcagtt 26400 ggcgacgagc agctagcgcg ctggcttca a acgcgcgagc ctgccgactt ggaggagcga 26460 cgcaaactaa tgatggccgc agtgctcgtt accgtggagc ttgagtgcat gcagcggttc 26520 tttgctgacc cggagatgca gcgcaagcta gaggaaacat tgcactacac ctttcgacag 26580 ggctacgtac gccaggcctg caagatctcc aacgtggagc tctgcaacct ggtctcctac 26640 cttggaattt tgcacgaaaa ccgccttggg caaaacgtgc ttcattccac gctcaag ggc 26700 gaggcgcgcc gcgactacgt ccgcgactgc gtttacttat ttctatgcta cacctggcag 26760 acggccatgg gcgtttggca gcagtgcttg gaggagtgca acctcaagga gctgcagaaa 26820 ctgctaaagc aaaacttgaa ggacctatgg acgg ccttca acgagcgctc cgtggccgcg 26880 cacctggcgg acatcatttt ccccgaacgc ctgcttaaaa ccctgcaaca gggtctgcca 26940 gacttcacca gtcaaagcat gttgcagaac tttaggaact ttatcctaga gcgctcagga 27000 atcttgcccg ccacctgctg tgcacttcct agcgactttg tgcccattaa gtaccgcgaa 27060 tgccctccgc cgctttgggg ccactgctac cttctgcagc tagccaacta ccttgcctac 27120 cactctgaca taatggaaga cgtgagcggt gacggtctac tggagtgtca ctgtcgctgc 27180 aacctatgca ccccgcaccg ctccctggtt tgcaattcgc agctgcttaa cgaaagtcaa 27240 attatcggta cctttgagct gcagggtccc tcgcctgacg aaaagtccgc ggctccgggg 27300 ttgaaactca ctccggggct gtggacgtcg gcttaccttc gcaaatttgt acctgaggac 27360 taccacgccc acgagattag gttctacgaa gaccaatccc gcccgccta a tgcggagctt 27420 accgcctgcg tcattaccca gggccacatt cttggccaat tgcaagccat caacaaagcc 27480 cgccaagagt ttctgctacg aaagggacgg ggggtttact tggaccccca gtccggcgag 27540 gagctcaacc caatcccccc gccgccgca g ccctatcagc agcagccgcg ggcccttgct 27600 tcccaggatg gcacccaaaa agaagctgca gctgccgccg ccacccacgg acgaggagga 27660 atactgggac agtcaggcag aggaggtttt ggacgaggag gaggaggaca tgatggaaga 27720 ctgggagagc ctagacgagg aagcttccga ggtcgaagag gtgtcagacg aaacaccgtc 27780 accctcggtc gcattcccct cgccggcgcc ccagaaatcg gcaaccggtt ccagcatggc 2 7840 tacaacctcc gctcctcagg cgccgccggc actgcccgtt cgccgaccca accgtagatg 27900 ggacaccact ggaaccaggg ccggtaagtc caagcagccg ccgccgttag cccaagagca 27960 acaacagcgc caaggctacc gctcatggcg cgggcacaag aacgccatag tt gcttgctt 28020 gcaagactgt gggggcaaca tctccttcgc ccgccgcttt cttctctacc atcacggcgt 28080 ggccttcccc cgtaacatcc tgcattacta ccgtcatctc tacagcccat actgcaccgg 28140 cggcagcggc agcaacagca gcggccacac agaagcaaag gcgaccggat agcaagactc 28200 tgacaaagcc caagaaatcc acagcggcgg cagcagcagg aggaggagcg ctgcgtctgg 28260 cgcccaac ga acccgtatcg acccgcgagc ttagaaacag gatttttccc actctgtatg 28320 ctatatttca acagagcagg ggccaagaac aagagctgaa aataaaaaac aggtctctgc 28380 gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga tcagcttcgg cgcacgctgg 28440 aagacgcgga ggctctcttc agtaaatact gcgcgctgac tcttaaggac tagtttcgcg 28500 ccctttctca aatttaagcg cgaaaactac gtcatctcca gcggccacac ccggcgccag 28560 cacctgttgt cagcgccatt atgagcaagg aaattcccac gccctacatg tggagttacc 28620 agccacaaat gggacttgcg gctggagctg cccaagacta ctcaacccga ataaactaca 28680 tgagcgcggg accccacat g atatcccggg tcaacggaat acgcgcccac cgaaaccgaa 28740 ttctcctgga acaggcggct attaccacca cacctcgtaa taaccttaat ccccgtagtt 28800 ggcccgctgc cctggtgtac caggaaagtc ccgctcccac cactgtggta cttcccagag 2886 0 acgcccaggc cgaagttcag atgactaact caggggcgca gcttgcgggc ggctttcgtc 28920 acagggtgcg gtcgcccggg cagggtataa ctcacctgac aatcagaggg cgaggtattc 28980 agctcaacga cgagtcggtg agctcctcgc ttggtctccg tccggacggg acatttcaga 29040 tcggcggcgc cggccgctct tcattcacgc ctcgtcaggc aatcctaact ctgcagacct 29100 cgtcctctga gccg cgctct ggaggcattg gaactctgca atttattgag gagtttgtgc 29160 catcggtcta ctttaacccc ttctcgggac ctcccggcca ctatccggat caatttattc 29220 ctaactttga cgcggtaaag gactcggcgg acggctacga ctgaatgtta agtggagagg 29280 c agagcaact gcgcctgaaa cacctggtcc actgtcgccg ccacaagtgc tttgcccgcg 29340 actccggtga gttttgctac tttgaattgc ccgaggatca tatcgagggc ccggcgcacg 29400 gcgtccggct taccgcccag ggagagcttg cccgtagcct gattcgggag tttacccagc 29460 gccccctgct agttgagcgg gacaggggac cctgtgttct cactgtgatt tgcaactgtc 29520 ctaaccctgg attacatcaa gatcctctag ttaatgtca g gtcgcctaag tcgattaact 29580 agagtacccg gggatctttat tccctttaac taataaaaaa aaataataaa gcatcactta 29640 cttaaaatca gttagcaaat ttctgtccag tttatcagc agcacctcct tgccctcctc 29700 ccagctctgg tattgcagct tcctcctggc tgcaaacttt ctccacaatc taaatggaat 29760 gtcagtttcc tcctgttcct gtccatccgc acccactatc ttcatgttgt tgcagatgaa cgaac ctcta gttacctcca atggcatgct 30000 tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc ggcaacctta cctcccaaaa 30060 tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca aacataaacc tggaaatatc 30120 tgcacccctc ac agttacct cagaagccct aactgtggct gccgccgcac ctctaatggt 30180 cgcgggcaac acactcacca tgcaatcaca ggccccgcta accgtgcacg actccaaact 30240 tagcattgcc acccaaggac ccctcacagt gtcagaagga aagctagccc tgcaaacatc 30300 aggccccctc accaccaccg atagcagtac ccttactatc actgcctcac cccctctaac 30360 tactgccact ggtagcttgg gcattgactt gaaagagccc atttatacac aaaatggaaa 3 0420 actaggacta aagtacgggg ctcctttgca tgtaacagac gacctaaaca ctttgaccgt 30480 agcaactggt ccaggtgtga ctattaataa tacttccttg caaactaaag ttactggagc 30540 cttgggtttt gattcacaag gcaatatgca acttaatgta gcaggaggac taaggattga 30600 ttctcaaaac agacgcctta tacttgatgt tagttatccg tttgatgctc aaaaccaact 30660 aaatctaaga ctaggacagg gccctctttt tataaactca gcccacaact tggatattaa 30720 ctacaacaaa ggcctttaact tgtttacagc ttcaaacaat tccaaaaagc ttgaggttaa 30780 cctaagcact gccaaggggt tgatgtttga cgctacagcc atagccatta atgcaggaga 308 40 tgggcttgaa tttggttcac ctaatgcacc aaacacaaat cccctcaaaa caaaaattgg 30900 ccatggccta gaatttgatt caaacaaggc tatggttcct aaactaggaa ctggccttag 30960 ttttgacagc acaggtgcca ttacagtagg aaacaaaaat aatgataagc taactttgtg 31020 gaccggaata aaccctccac ctaactgtca aattgtggaa aacactaata caaatgatgg 31080 caaacttact ttagtatag taaaaaatgg agggcttgtt aatggctacg tgtctctagt 31140 tggtgtatca gacactgtga accaaatgtt cacacaaaag acagcaaaca tccaattaag 31200 attatatttt gactcttctg gaaatctatt aactgaggaa tcagacttaa aaattccact 31260 taaaaata aa tcttctacag cgaccagtga aactgtagcc agcagcaaag cctttatgcc 31320 aagtactaca gctttatccct tcaacaccac tactagggat agtgaaaact acattcatgg 31380 aatatgttac tacatgacta gttatgatag aagtctattt cccttgaaca tttctataat 31440 gctaa acagc cgtatgattt cttccaatgt tgcctatgcc atacaatttg aatggaatct 31500 aaatgcaagt gaatctccag aaagcaacat agctacgctg accacatccc cctttttctt 31560 ttcttacatt acagaagacg acaactaaag aatcgtttgt gttatgtttc aacgtttta 31620 tttttcaatt gcagaaaatt tcaagtcatt tttcattcag tagtatagcc ccaccaccac 31680 atagcttata cagat caccg taccttaatc aaactcacag aaccctagta ttcaacctgc 31740 cacctccctc ccaacaca gagtacacag tcctttctcc ccggctggcc ttaaaaagca 31800 tcatatcatg ggtaacagac atattcttag gtgttatatt ccacacggtt tcctgtcgag 31860 ccaa acgctc atcagtgata ttaataaact ccccgggcag ctcacttaag ttcatgtcgc 31920 tgtccagctg ctgagccaca ggctgctgtc caacttgcgg ttgcttaacg ggcggcgaag 31980 gagaagtcca cgcctacatg ggggtagagt cataatcgtg catcaggata gggcggtggt 32040 gctgcagcag cgcgcgaata aactgctgcc gccgccgctc cgtcctgcag gaatacaaca 32100 tggcagtggt ctcctcagcg atgattcgca ccgcccgcag cataaggcgc cttgtcctcc 32160 gggcacagca gcgcaccctg atctcactta aatcagcaca gtaactgcag cacagcacca 32220 caatattgtt caaaatccca cagtgcaagg cgctgtatcc aaagctcatg gcggggacca 32280 cagaac ccac gtggccatca taccacaagc gcaggtagat taagtggcga cccctcataa 32340 acacgctgga cataaacatt acctcttttg gcatgttgta attcaccacc tcccggtacc 32400 atataaacct ctgattaaac atggcgccat ccaccaccat cctaaaccag ctggccaaaa 32460 cctgcccgcc ggctatacac tgcagggaac cgggactgga acaatgacag tggagagccc 32520 aggactcgta accatggatc atcatgctcg tcatg atatc aatgttggca caacacaggc 32580 acacgtgcat acacttcctc aggattacaa gctcctcccg cgttagaacc atatcccagg 32640 gaacaaccca ttcctgaatc agcgtaaatc ccacactgca gggaagacct cgcacgtaac 32700 tcacgttgtg cattgtcaaa gtgttacatt cgggcagcag cggatgatcc tccagtatgg 32760 tagcgcgggt ttctgtctca aaaggaggta gacgatccct actgtacgga gtgcgccgag 32820 acaaccgaga tcgtgttggt cgtagtgtca tgccaaatgg aacgccggac gtagtcatat 32880 ttcctgaagc aaaaccaggt gcgggcgtga caaacagatc tgcgtctccg gtctcgccgc 32940 ttagatcgct ctgtgtagta gttgtagtat atccactctc tcaaagcatc caggcgcccc 33000 ctggcttcgg gttctatgta aactccttca tgcgccgctg ccctgataac atccaccacc 33060 gcagaataag ccacacccag ccaacctaca cattcgttct gcgagtcaca cacgggagga 33120 gcgggaagag ctggaagaac catgtttttt ttttattcc aaaagattat ccaaaacctc 33180 aaaatgaaga tctattaagt gaacgcgctc ccctccggtg gcgtggtcaa actctacagc 33240 cac cttctca atatatctct 33420 aagcaaatcc cgaatattaa gtccggccat tgtaaaaatc tgctccagag cgccctccac 33480 cttcagcctc aagcagcgaa tcatgattgc aaaaattcag gttcctcaca gacctgtata 33540 agattcaaaa gcggaacatt aacaa aaata ccgcgatccc gtaggtccct tcgcagggcc 33600 agctgaacat aatcgtgcag gtctgcacgg accagcgcgg ccacttcccc gccaggaacc 33660 atgacaaaag aacccacact gattatgaca cgcatactcg gagctatgct aaccagcgta 33720 gccccgatgt aagcttgttg catgggcggc gatataaaat gcaaggtgct gctcaaaaaa 33780 tcaggcaaag cctcgcgcaa aaaagaaagc acatcgtagt catgctcatg cagataaagg 33 840 caggtaagct ccggaaccac cacagaaaaa gacaccattt ttctctcaaa catgtctgcg 33900 ggtttctgca taaacacaaa ataaaataac aaaaaaacat ttaaacatta gaagcctgtc 33960 ttacaacagg aaaaacaacc cttataagca taagacggac tacggccatg ccggcgtgac 34020 cgtaaaaaaa ctggtcaccg tgattaaaaa gcaccaccga cagctcctcg gtcatgtccg 34080 gagtcataat gtaagactcg gtaaacacat caggttgatt cacatcggtc agtgctaaaa 34140 agcgaccgaa atagcccggg ggaatacata cccgcaggcg tagagacaac attacagccc 34200 ccataggagg tataacaaaa ttaataggag agaaaaacac ataaacacct gaaaaaccct 34260 cctgcctagg caaaatagca ccctcccgct ccagaacaac atacagcgct tccacagcgg 34320 cagccataac agtcagcctt accagtaaaa aagaaaacct attaaaaaaa caccactcga 34380 cacggcacca gctcaatcag tcacagtgta aaaaagggcc aagtgcagag cgagtata 34 440 taggactaaa aaatgacgta acggttaaag tccacaaaaa acacccagaa aaccgcacgc 34500 gaacctacgc ccagaaacga aagccaaaaa acccacaact tcctcaaatc gtcacttccg 34560 ttttcccacg ttacgtcact tcccatttta agaaaactac aattcccaac acatacaagt 34620 tactccgccc taaaacctac gtcacccgcc ccgttcccac gccccgcgcc acgtcacaaa 34680ctccaccccc tcat tatcat attggcttca atccaaaata aggtatatta ttgatgatg 34739 <210> 24 <211> 37666 <212> DNA <213> artificial sequence <220> <223> plasmid #2 vector <400> 24 ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60 aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120 ggctgcggcg agcggtatca gctcactcaa aggcggta at acggttatcc acagaatcag 180 gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240 aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300 gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360 ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420 cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480 cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540 gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600 cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660 agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720 ctctgctgaa gccagttacc ttcgga aaaa gagttggtag ctcttgatcc ggcaaacaaa 780 ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840 gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900 cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960 attaaaaatg aagttttaaa tcaatctaaa gtatata tga gtaaacttgg tctgacagtt 1020 accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080 ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140 gtgctgcaat gataccgcga gacccac gct caccggctcc agatttatca gcaataaacc 1200 agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260 ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320 ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380 cgtagaaagc cagtccgcag aaacggtgct gaccccgg at gaatgtcagc tactgggcta 1440 tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500 ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560 cgccctctgg taaggttggg aagccctg ca aagtaaactg gatggctttc ttgccgccaa 1620 ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680 tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740 gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800 cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860 aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920 tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980 atctcctgtc atctcacctt gctcctgccg aga aagtatc catcatggct gatgcaatgc 2040 ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100 tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160 agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220 gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280 gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340 tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400 tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgcctt ctat cgccttcttg 2460 acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520 gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580 gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640 aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700 gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760 tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820 gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgc gctt 2880 aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940 atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000 tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060 atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120 tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180 aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240 gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 33 00 cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360 gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420 ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480 ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540 atgacggtaa atggcccgcc tggcattatg ccc agtacat gaccttatgg gactttccta 3600 cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660 acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg 3720 acgtcaatgg gagtttgttt tggca ccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780 actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc t gtgttcctg gtgctgctgc 4020 cactggtgtc cagccagtgt gtgaacctga ccaccaggac ccaacttcct cctgcctaca 4080 ccaactcctt caccagggga gtctactacc ctgacaaggt gttcaggtcc tctgtgctgc 4140 acagcaccca ggacctgttc ctgccattct tcagcaatgt gacctggttc catgccatcc 4200 atgtgtctgg caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg 4260 gagtctactt tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca 4320 ccctggacag caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta 4380 aggtgtgtga gttccagttc tgtaatgacc cattcctggg agtctactac cacaagaaca 4440 acaagtcctg gatggagtct gagttcaggg tctactcctc tgccaacaac tgtacctttg 4500 aatatgtgag ccaaccattc ctgatggact tggagggcaa gcagggcaac ttcaagaacc 4560 tgagggagtt tgtgttcaag aacattgatg gctactt caa gatttacagc aaacacacac 4620 caatcaacct ggtgagggac ctgccacagg gcttctctgc cttggaacca ctggtggacc 4680 tgccaattgg catcaacatc accaggttcc agaccctgct ggctctgcac aggtcctacc 4740 tgacacctgg agactcctcc tctggctgga cagcaggagc agcagcctac tatgtgggct 4800 acctccaacc aaggaccttc ctgctgaaat acaatgagaa tggcaccatc acagatg ctg 4860 tggactgtgc cctggaccca ctgtctgaga ccaagtgtac cctgaaatcc ttcacagtgg 4920 agaagggcat ctaccagacc agcaacttca gggtccaacc aacagagagc attgtgaggt 4980 ttccaaacat caccaacctg tgtccatttg gagaggtgtt caatgcca cc aggtttgcct 5040 ctgtctatgc ctggaacagg aagaggatta gcaactgtgt ggctgactac tctgtgctct 5100 acaactctgc ctccttcagc accttcaagt gttatggagt gagcccaacc aaactgaatg 5160 acctgtgttt caccaatgtc tatgctgact cctttgtgat taggggat gaggtgagac 5220 agattgcccc tggacaaaca ggcaagattg ctgactacaa ctacaaactg cctgatgact 5280 t cacaggctg tgtgattgcc tggaacagca acaacctgga cagcaaggtg ggaggcaact 5340 acaactacct ctacagactg ttcaggaaga gcaacctgaa accatttgag agggacatca 5400 gcacagagat ttaccaggct ggcagcacac catgtaatgg agtggagggc ttcaactgtt 5460 act ttccact ccaatcctat ggcttccaac caaccaatgg agtgggctac caaccataca 5520 gggtggtggt gctgtccttt gaactgctcc atgcccctgc cacagtgtgt ggaccaaaga 5580 agagcaccaa cctggtgaag aacaagtgg tgaacttcaa cttcaatgga ctgacaggca 5640 caggagtgct gacagagagc aacaagaagt tcctgccatt ccaacagttt ggcagggaca 5700 ttgctgac ac cacagatgct gtgagggacc cacagacctt ggagattctg gacatcacac 5760 catgttcctt tggaggagtg tctgtgatta cacctggcac caacaccagc aaccaggtgg 5820 ctgtgctcta ccaggatgtg aactgtactg aggtgcctgt ggctatccat gctgaccaac 5880 ttaca ccaac ctggagggtc tacagcacag gcagcaatgt gttccagacc agggctggct 5940 gtctgattgg agcagagcat gtgaacaact cctatgagtg tgacatccca attggagcag 6000 gcatctgtgc ctcctaccag acccagacca tcctcaggtc tgtggcaagc cagagcatca 6060 ttgcctacac aatgagtctg ggagcagaga actctgtggc ttacagcaac aacagcattg 6120 ccatcccaac caacttcacc atctctgt ga ccacagagat tctgcctgtg agtatgacca 6180 agacctctgt ggactgtaca atgtatatct gtggagacag cacagagtgt agcaacctgc 6240 tgctccaata tggctccttc tgtacccaac ttaacagggc tctgacaggc attgctgtgg 6300 aacaggacaa gaacacccag gaggtgtttg cccaggtgaa gcagatttac aagacacctc 6360 caatcaagga ctttggaggc ttcaacttca gccagattct gcctgaccca agcaagccaa 6420 gcaagaggtc cttcattgag gacctgctgt tcaacaaggt gaccctggct gatgctggct 6480 tcatcaagca atatggagac tgtctgggag acattgctgc cagggacctg atttgtgccc 6540 agaagttcaa tggactgaca gtgctgcct c cactgctgac agatgagatg attgcccaat 6600 acacctctgc cctgctggct ggcaccatca cctctggctg gacctttgga gcaggagcag 6660 ccctccaaat cccatttgct atgcagatgg cttacaggtt caatggcatt ggagtgaccc 6720 agaatgtgct ctatgagaac c agaaactga ttgccaacca gttcaactct gccattggca 6780 agattcagga ctccctgtcc agcacagcct ctgccctggg caaactccaa gatgtggtga 6840 accagaatgc ccaggctctg aacaccctgg tgaagcaact ttccagcaac tttggagcca 6900 tctcctctgt gctgaatgac atcctgagca gactggacaa ggtggaggct gaggtccaga 6960 ttgacagact gattacaggc agactccaat ccctccaaac ct atgtgacc caacaactta 7020 tcagggctgc tgagattagg gcatctgcca acctggctgc caccaagatg agtgagtgg 7080 tgctgggaca aagcaagagg gtggacttct gtggcaaggg ctaccacctg atgagttttc 7140 cacagtctgc ccctcatgga gtggtgttcc tgcatgt gac ctatgtgcct gcccaggaga 7200 agaacttcac cacagcccct gccatctgcc atgatggcaa ggctcacttt ccaagggagg 7260 gagtgtttgt gagcaatggc acccactggt ttgtgaccca gaggaacttc tatgaaccac 7320 agattatcac cacagacaac acctttgtgt ctggcaactg tgatgtggtg attggcattg 7380 tgaacaacac agtctatgac ccactccaac ctgaactgga ctccttcaag gag gaactgg 7440 acaaatactt caagaaccac accagccctg atgtggacct gggagacatc tctggcatca 7500 atgcctctgt ggtgaacatc cagaaggaga ttgacagact gaatgaggtg gctaagaacc 7560 tgaatgagtc cctgattgac ctccaagaac tgggcaaata tgaacaatac atca agtggc 7620 catgaaaatt gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa 7680 acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 7740 tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 7800 aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtat cttaac 7860 gcggatctgg gcgtggttaa gggtgggaaa gaatatataa ggtgggggtc ttatgtagtt 7920 ttgtatctgt tttgcagcag ccgccgccgc catgagcacc aactcgtttg atggaagcat 7980 tgtgagctca tatttgacaa cgcgcatgcc cccatgg gcc ggggtgcgtc agaatgtgat 8040 gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 8100 gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 8160 caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 8220 ttcccgttca tccgcccgcg atgacaagtt gacggctctt tt ggcacaat tggattcttt 8280 gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 8340 cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 8400 ttggatttgg atcaagcaag tgtct tgctg tctttattta ggggttttgc gcgcgcggta 8460 ggcccgggac cagcggtctc ggtcgttgag ggtcctgtgt attttttcca ggacgtggta 8520 aaggtgactc tggatgttca gatacatggg cataagcccg tctctggggt ggaggtagca 8580 ccactgcaga gcttcatgct gcggggtggt gttgtagatg atccagtcgt agcaggagcg 8640 ctgggcgtgg tgcctaaaaa tgtctttcag tagcaagctg attgccaggg gcaggccctt 8700 ggtg taagtg tttacaaagc ggttaagctg ggatgggtgc atacgtgggg atatgagatg 8760 catcttggac tgtattttta ggttggctat gttcccagcc atatccctcc ggggattcat 8820 gttgtgcaga accaccagca cagtgtatcc ggtgcacttg ggaaatttgt catgtagctt 8880 a gaaggaaat gcgtggaaga acttggagac gcccttgtga cctccaagat tttccatgca 8940 ttcgtccata atgatggcaa tgggcccacg ggcggcggcc tgggcgaaga tatttctggg 9000 atcactaacg tcatagttgt gttccaggat gagatcgtca taggccattt ttacaaagcg 9060 cgggcggagg gtgccagact gcggtataat ggttccatcc ggcccagggg cgtagttacc 9120 ctcacagatt tgcattt ccc acgctttgag ttcagatggg gggatcatgt ctacctgcgg 9180 ggcgatgaag aaaacggttt ccggggtagg ggagatcagc tgggaagaaa gcaggttcct 9240 gagcagctgc gacttaccgc agccggtggg cccgtaaatc acacctatta ccggctgcaa 93 00 ctggtagtta agagagctgc agctgccgtc atccctgagc aggggggcca cttcgttaag 9360 catgtccctg actcgcatgt tttccctgac caaatccgcc agaaggcgct cgccgcccag 9420 cgatagcagt tcttgcaagg aagcaaagtt tttcaacggt ttgagaccgt ccgccgtagg 9480 catgcttttg agcgtttgac caagcagttc caggcggtcc cacagctcgg tcacctgctc 9540 tacggcatct cgat ccagca tatctcctcg tttcgcgggt tggggcggct ttcgctgtac 9600 ggcagtagtc ggtgctcgtc cagacgggcc agggtcatgt ctttccacgg gcgcagggtc 9660 ctcgtcagcg tagtctgggt cacggtgaag gggtgcgctc cgggctgcgc gctggcc agg 9720 gtgcgcttga ggctggtcct gctggtgctg aagcgctgcc ggtcttcgcc ctgcgcgtcg 9780 gccaggtagc atttgaccat ggtgtcatag tccagcccct ccgcggcgtg gcccttggcg 9840 cgcagcttgc ccttggagga ggcgccgcac gaggggcagt gcagactttt gagggcgtag 9900 agcttgggcg cgagaaatac cgattccggg gagtaggcat ccgcgccgca ggccccgcag 9960 acggtctcgc attccacgag ccaggtgag c tctggccgtt cggggtcaaa aaccaggttt 10020 cccccatgct ttttgatgcg tttcttacct ctggtttcca tgagccggtg tccacgctcg 10080 gtgacgaaaa ggctgtccgt gtccccgtat acagacttga gaggcctgtc ctcgagcggt 10140 gttccgcggt cctcctcgta tagaaactcg gaccactctg agacaaaggc tcgcgtccag 10200 gccagcacga aggaggctaa gtgggagggg tagcggtcgt tgtccactag ggggtccact 10260 cgctccaggg tgtgaagaca catgtcgccc tcttcggcat caaggaaggt gattggtttg 10320 taggtgtagg ccacgtgacc gggtgttcct gaaggggggc tataaaaggg ggtgggggcg 10380 cgttcgtcct cactctcttc cgcatcgctg tctgcgag gg ccagctgttg gggtgagtac 10440 tccctctgaa aagcgggcat gacttctgcg ctaagattgt cagtttccaa aaacgaggag 10500 gatttgatat tcacctggcc cgcggtgatg cctttgaggg tggccgcatc catctggtca 10560 gaaaagacaa tcttt ttgtt gtcaagcttg gtggcaaacg acccgtagag ggcgttggac 10620 agcaacttgg cgatggagcg cagggtttgg tttttgtcgc gatcggcgcg ctccttggcc 10680 gcgatgttta gctgcacgta ttcgcgcgca acgcaccgcc attcgggaaa gacggtggtg 10740 cgctcgtcgg gcaccaggtg cacgcgccaa ccgcggttgt gcagggtgac aaggtcaacg 10800 ctggtggcta cctctccgcg taggcgctcg ttggt ccagc agaggcggcc gcccttgcgc 10860 gagcagaatg gcggtagggg gtctagctgc gtctcgtccg gggggtctgc gtccacggta 10920 aagaccccgg gcagcaggcg cgcgtcgaag tagtctatct tgcatccttg caagtctagc 10980 gcctgctgcc atgc gcgggc ggcaagcgcg cgctcgtatg ggttgagtgg gggaccccat 11040 ggcatggggt gggtgagcgc ggaggcgtac atgccgcaaa tgtcgtaaac gtagaggggc 11100 tctctgagta ttccaagata tgtagggtag catcttccac cgcggatgct ggcgcgcacg 11160 taatcgtata gttcgtgcga gggagcgagg aggtcgggac cgaggttgct acgggcgggc 11220 tgctctgctc ggaagactat ctgcctgaag atggcatgtg agttggatga tatggtt gga 11280 cgctggaaga cgttgaagct ggcgtctgtg agacctaccg cgtcacgcac gaaggaggcg 11340 taggagtcgc gcagcttgtt gaccagctcg gcggtgacct gcacgtctag ggcgcagtag 11400 tccagggttt ccttgatgat gtcatactta tcct gtccct tttttttcca cagctcgcgg 11460 ttgaggacaa actcttcgcg gtctttccag tactcttgga tcggaaaccc gtcggcctcc 11520 gaacggtaag agcctagcat gtagaactgg ttgacggcct ggtaggcgca gcatcccttt 11580 tctacgggta gcgcgtatgc ctgcgcggcc ttccggagcg aggtgtgggt gagcgcaaag 11640 gtgtccctga ccatgacttt gaggtactgg tatttgaagt cagtgtcgtc gcatccgccc 1 1700 tgctcccaga gcaaaaagtc cgtgcgcttt ttggaacgcg gatttggcag ggcgaaggtg 11760 acatcgttga agagtatctt tcccgcgcga ggcataaagt tgcgtgtgat gcggaagggt 11820 cccggcacct cggaacggtt gttaattacc t gggcggcga gcacgatctc gtcaaagccg 11880 ttgatgttgt ggcccaat gtaaagttcc aagaagcgcg ggatgccctt gatggaaggc 11940 aattttttaa gttcctcgta ggtgagctct tcaggggagc tgagccccgtg ctctgaaagg 12000 gcccagtctg caagatgagg gttggaagcg acgaatgagc tccacaggtc acgggccatt 12060 agcatttgca ggtggtcgcg aaaggtccta aactggcgac ctatggccat tttttctggg 12120 gtgatgcagt agaaggtaag cgggtcttgt tcccagcggt cccatccaag gttcgcggct 12180 aggtctcgcg cggcagtcac tagaggctca tctccgccga acttcatgac cagcatgaag 12240 ggcacgagct gcttcccaaa ggcccccatc caagtatagg tctctacatc gtag gtgaca 12300 aagagacgct cggtgcgagg atgcgagccg atcgggaaga actggatctc ccgccaccaa 12360 ttggaggagt ggctattgat gtggtgaaag tagaagtccc tgcgacgggc cgaacactcg 12420 tgctggcttt tgtaaaaacg tgcgcagtac tggcagcggt gcacgggctg tacatcctgc 12480 acgaggttga cctgacgacc gcgcacaagg aagcagagtg ggaatttgag cccctcgcct 12540 ggcgggt ttg gctggtggtc ttctacttcg gctgcttgtc cttgaccgtc tggctgctcg 12600 aggggagtta cggtggatcg gaccaccacg ccgcgcgagc ccaaagtcca gatgtccgcg 12660 cgcggcggtc ggagcttgat gacaacatcg cgcagatggg ag ctgtccat ggtctggagc 12720 tcccgcggcg tcaggtcagg cgggagctcc tgcaggttta cctcgcatag acgggtcagg 12780 gcgcgggcta gatccaggtg atacctaatt tccaggggct ggttggtggc ggcgtcgatg 12840 gcttgcaaga ggccgcatcc ccgcggcgcg actacggtac cgcgcggcgg gcggtgggcc 12900 gcgggggtgt ccttggatga tgcatctaaa agcggtgacg cgggcgagcc cccggaggta 12960 gggggggctc cggacccgcc ggg agagggg gcaggggcac gtcggcgccg cgcgcgggca 13020 ggagctggtg ctgcgcgcgt aggttgctgg cgaacgcgac gacgcggcgg ttgatctcct 13080 gaatctggcg cctctgcgtg aagacgacgg gcccggtgag cttgaacctg aaagagagtt 13140 cgacagaatc aatttcggtg tcgttgacgg cggcctggcg caaaatctcc tgcacgtctc 13200 ctgagttgtc ttgataggcg atctcggcca tgaactgctc gatctcttcc tcctggagat gattga gctc cacgtgccgg gcgaagacgg 13440 cgtagtttcg caggcgctga aagaggtagt tgagggtggt ggcggtgtgt tctgccacga 13500 agaagtacat aacccagcgt cgcaacgtgg attcgttgat atcccccaag gcctcaaggc 13560 gctccatggc ctcgtagaag tccacggcga agttgaaaaa ctgggagttg cgcgccgaca 13620 cggttaactc ctcctccaga agacggatga gctcggcgac agtgtcgcgc acctcgcgct 13680 caaaggctac aggggcctct tcttcttctt caatctcctc ttccataagg gcctcccctt 13740 cttcttcttc tggcggcggt gggggagggg ggacacggcg gcgacgacgg cgcaccggga 13800 ggcggtcgac aaagcgctcg atcatctccc cgcggc t ccgccgccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc 14040 tctcgagaaa ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg 14100 gcagcgggcg gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt 14160 aggcggtctt gagacggcgg atggtcgaca gaagcaccat gtccttgggt ccggcctgct 14220 gaatgcgcag gcggtcggcc atgccccagg cttcgttttg acatcggcgc aggtctttgt 14280 agtagtcttg catgagcctt tctaccggca cttcttcttc tccttcctct tgtcctgcat 14340 ctcttgcatc tatcgctgcg gcggcggcgg agtttggccg taggtggcgc cctcttcctc 14400 ccatgcgtgt gaccccgaag c ccctcatcg gctgaagcag ggctaggtcg gcgacaacgc 14460 gctcggctaa tatggcctgc tgcacctgcg tgagggtaga ctggaagtca tccatgtcca 14520 caaagcggtg gtatgcgccc gtgttgatgg tgtaagtgca gttggccata acggaccagt 14580 taacggtctg gtgacccggc tgcgagagct cggtgtacct gagacgcgag taagccctcg 14640 agtcaaatac gtagtcgttg caagtccgca ccaggtactg gtatcccacc aaaaagtgcg 14 700 gcggcggctg gcggtagagg ggccagcgta gggtggccgg ggctccgggg gcgagatctt 14760 ccaacataag gcgatgatat ccgtagatgt acctggacat ccaggtgatg ccggcggcgg 14820 tggtggaggc gcgcggaaag tcgcggacgc ggttccagat gttgcgcagc ggcaaaaagt 14880 gctccatggt cgggacgctc tggccggtca ggcgcgcgca atcgttgacg ctctagcgtg 14940 caaaaggaga gcctgtaagc gggcactctt ccgtggtctg gtggataaat tcgcaagggt 15000 atcatggcgg acgaccgggg ttcgagcccc gtatccggcc gtccgccgtg atccatgcgg 15060 ttaccgcccg cgtgtcgaac ccaggtgtgc gacgtcagac aacgggggag tgctcctttt 15120 ggcttcc ttc caggcgcggc ggctgctgcg ctagcttttt tggccactgg ccgcgcgcag 15180 cgtaagcggt taggctggaa agcgaaagca ttaagtggct cgctccctgt agccggaggg 15240 ttaattttcca agggttgagt cgcgggaccc ccggttcgag tct cggaccg gccggactgc 15300 ggcgaacggg ggtttgcctc cccgtcatgc aagaccccgc ttgcaaattc ctccggaaac 15360 agggacgagc cccttttttg cttttcccag atgcatccgg tgctgcggca gatgcgcccc 15420 cctcctcagc agcggcaaga gcaagagcag cggcagacat gcagggcacc ctcccctcct 15480 cctaccgcgt caggaggggc gacatccgcg gttgacgcgg cagcagatgg tgattacgaa 15540 cccccgcggc gccggg cccg gcactacctg gacttggagg agggcgaggg cctggcgcgg 15600 ctaggagcgc cctctcctga gcggcaccca agggtgcagc tgaagcgtga tacgcgtgag 15660 gcgtacgtgc cgcggcagaa cctgtttcgc gaccgcgagg gagaggagcc cgaggagatg 1 5720 cgggatcgaa agttccacgc agggcgcgag ctgcggcatg gcctgaatcg cgagcggttg 15780 ctgcgcgagg aggactttga gcccgacgcg cgaaccggga ttagtcccgc gcgcgcacac 15840 gtggcggccg ccgacctggt aaccgcatac gagcagacgg tgaaccagga gattaacttt 15900 caaaaaagct ttaacaacca cgtgcgtacg cttgtggcgc gcgaggaggt ggctatagga 15960 ctgatgcatc tgggggacttt tg taagcgcg ctggagcaaa acccaaatag caagccgctc 16020 atggcgcagc tgttccttat agtgcagcac agcagggaca acgaggcatt cagggatgcg 16080 ctgctaaaca tagtagagcc cgagggccgc tggctgctcg atttgataaa catcctgcag 16140 ag catagtgg tgcaggagcg cagcttgagc ctggctgaca aggtggccgc catcaactat 16200 tccatgctta gcctgggcaa gttttacgcc cgcaagatat accatacccc ttacgttccc 16260 atagacaagg aggtaaagat cgaggggttc tacatgcgca tggcgctgaa ggtgcttacc 16320 ttgagcgacg acctgggcgt ttatcgcaac gagcgcatcc acaaggccgt gagcgtgagc 16380 cggcggcgcg agctcagcga ccgcgagctg at gcacagcc tgcaaagggc cctggctggc 16440 acgggcagcg gcgatagaga ggccgagtcc tactttgacg cgggcgctga cctgcgctgg 16500 gccccaagcc gacgcgccct ggaggcagct ggggccggac ctgggctggc ggtggcaccc 16560 gcgcgcg ctg gcaacgtcgg cggcgtggag gaatatgacg aggacgatga gtacgagcca 16620 gaggacggcg agtactaagc ggtgatgttt ctgatcagat gatgcaagac gcaacggacc 16680 cggcggtgcg ggcggcgctg cagagccagc cgtccggcct taactccacg gacgactggc 16740 gccaggtcat ggaccgcatc atgtcgctga ctgcgcgcaa tcctgacgcg ttccggcagc 16800 agccgcaggc caaccggctc tccgcaattc tggaagcgg t ggtcccggcg cgcgcaaacc 16860 ccacgcacga gaaggtgctg gcgatcgtaa acgcgctggc cgaaaacagg gccatccggc 16920 ccgacgaggc cggcctggtc tacgacgcgc tgcttcagcg cgtggctcgt tacaacagcg 16980 gcaacgt gca gaccaacctg gaccggctgg tgggggatgt gcgcgaggcc gtggcgcagc 17040 gtgagcgcgc gcagcagcag ggcaacctgg gctccatggt tgcactaaac gccttcctga 17100 gtacacagcc cgccaacgtg ccgcggggac aggaggacta caccaacttt gtgagcgcac 17160 tgcggctaat ggtgactgag acaccgcaaa gtgaggtgta ccagtctggg ccagactatt 17220 ttttccagac cagtagacaa ggcctgcaga ccgtaaacct gagccaggct tt caaaaact 17280 tgcaggggct gtggggggtg cgggctccca caggcgaccg cgcgaccgtg tctagcttgc 17340 tgacgcccaa ctcgcgcctg ttgctgctgc taatagcgcc cttcacggac agtggcagcg 17400 tgtcccggga cacatagcccta ggtcacttgc tgacactgta ccgcgaggcc ataggtcagg 17460 cgcatgtgga cgagcatact ttccaggaga ttacaagtgt cagccgcgcg ctggggcagg 17520 aggacacggg cagcctggag gcaaccctaa actacctgct gaccaaccgg cggcagaaga 17580 tcccctcgtt gcacagttta aacagcgagg aggagcgcat tttgcgctac gtgcagcaga 17640 gcgtgagcct taacctgatg cgcgacgggg taacgcccag cgtggcgctg gacatgaccg 17700 cg cgcaacat ggaaccgggc atgtatgcct caaaccggcc gtttatcaac cgcctaatgg 17760 actacttgca tcgcgcggcc gccgtgaacc ccgagtattt caccaatgcc atcttgaacc 17820 cgcactggct accgccccct ggtttctaca ccgggggatt cgaggtgccc gagggtaac g 17880 atggattcct ctgggacgac atagacgaca gcgtgttttc cccgcaaccg cagaccctgc 17940 tagagttgca acagcgcgag caggcagagg 181 20 aggagtacct aaacaactcg ctgctgcagc cgcagcgcga aaaaaacctg cctccggcat 18180 ttcccaacaa cgggatagag agcctagtgg acaagatgag tagatggaag acgtacgcgc 18240 aggagcacag ggacgtgcca ggcccgcgcc cgcccacccg tcgt caaagg cacgaccgtc 18300 agcggggtct ggtgtgggag gacgatgact cggcagacga cagcagcgtc ctggatttgg 18360 gagggagtgg caacccgttt gcgcaccttc gccccaggct ggggagaatg ttttaaaaaa 18420 aaaaaagcat gatgcaaaat aaaaaactca ccaaggccat ggcaccgagc gttggttttc 18480 ttgtattccc cttagtatgc ggcgcgcggc gatgtatgag gaaggtcctc ctccctccta 18540 cgagagt gtg gtgagcgcgg cgccagtggc ggcggcgctg ggttctccct tcgatgctcc 18600 cctggacccg ccgtttgtgc ctccgcggta cctgcggcct accgggggga gaaacagcat 18660 ccgttactct gagttggcac ccctattcga caccacccgt gtgtacctgg tggacaacaa 18720 gtcaacggat gtggcatccc tgaactacca gaacgaccac agcaactttc tgaccacggt 18780 cattcaaaac aatgactaca gcccggggga ggcaagcaca cagaccatca atcttgacga 18840 ccggtcgcac tggggcggcg acctgaaaac catcctgcat accaacatgc caaatgtgaa 18900 cgagttcatg tttaccaata agtttaaggc gcgggtgatg gtgtcgcgct tgcctactaa 18960 ggacaatcag gtggagctga aatacgagt g ggtggagttc acgctgcccg agggcaacta 19020 ctccgagacc atgaccatag accttatgaa caacgcgatc gtggagcact acttgaaagt 19080 gggcagacag aacggggttc tggaaagcga catcggggta aagtttgaca cccgcaactt 19140 cagactgggg tt tgaccccg tcactggtct tgtcatgcct ggggtatata caaacgaagc 19200 cttccatcca gacatcattt tgctgccagg atgcggggtg gacttcaccc acagccgcct 19260 gagcaacttg ttgggcatcc gcaagcggca acccttccag gagggcttta ggatcaccta 19320 cgatgatctg gagggtggta acattcccgc actgttggat gtggacgcct accaggcgag 19380 cttgaaagat gacaccgaac agggcggggg tggcgcaggc ggcagca aca gcagtggcag 19440 cggcgcggaa gagaactcca acgcggcagc cgcggcaatg cagccggtgg aggacatgaa 19500 cgatcatgcc attcgcggcg acacctttgc cacacgggct gaggagaagc gcgctgaggc 19560 cgaagcagcg gccgaagctg ccgccc ccgc tgcgcaaccc gaggtcgaga agcctcagaa 19620 gaaaccggtg atcaaacccc tgacagagga cagcaagaaa cgcagttaca acctaataag 19680 caatgacagc accttcaccc agtaccgcag ctggtacctt gcatacaact acggcgaccc 19740 tcagaccgga atccgctcat ggaccctgct ttgcactcct gacgtaacct gcggctcgga 19800 gcaggtctac tggtcgttgc cagacatgat gcaagacccc gtgaccttcc gct ccacgcg 19860 ccagatcagc aactttccgg tggtgggcgc cgagctgttg cccgtgcact ccaagagctt 19920 ctacaacgac caggccgtct actcccaact catccgccag tttacctctc tgacccacgt 19980 gttcaatcgc tttcccgaga accagatttt ggc gcgcccg ccagccccca ccatcaccac 20040 cgtcagtgaa aacgttcctg ctctcacaga tcacgggacg ctaccgctgc gcaacagcat 20100 cggaggagtc cagcgagtga ccattactga cgccagacgc cgcacctgcc cctacgttta 20160 caaggccctg ggcatagtct cgccgcgcgt cctatcgagc cgcacttttt gagcaagcat 20220 gtccatcctt atatcgccca gcaataacac aggctggggc ctgcgcttcc caagcaagat 2 0280 gtttggcggg gccaagaagc gctccgacca acacccagtg cgcgtgcgcg ggcactaccg 20340 cgcgccctgg ggcgcgcaca aacgcggccg cactgggcgc accaccgtcg atgacgccat 20400 cgacgcggtg gtggaggagg cgcgcaacta cacg cccacg ccgccaccag tgtccacagt 20460 ggacgcggcc attcagaccg tggtgcgcgg agcccggcgc tatgctaaaa tgaagagacg 20520 gcggaggcgc gtagcacgtc gccaccgccg ccgacccggc actgccgccc aacgcgcggc 20580 ggcggccctg cttaaccgcg cacgtcgcac cggccgacgg gcggccatgc gggccgctcg 20640 aaggctggcc gcgggtattg tcactgtgcc ccccaggtcc aggcgacgag cggccgccgc 2 0700 agcagccgcg gccattagtg ctatgactca gggtcgcagg ggcaacgtgt attgggtgcg 20760 cgactcggtt agcggcctgc gcgtgcccgt gcgcacccgc cccccgcgca actagattgc 20820 aagaaaaac tacttagact cgtactgttg tatgtatcca g cggcggcgg cgcgcaacga 20880 agctatgtcc aagcgcaaaa tcaaagaaga gatgctccag gtcatcgcgc cggagatcta 20940 tggccccccg aagaaggaag agcaggatta caagccccga aagctaaagc gggtcaaaaa 21000 gaaaaagaaa gatgatgatg atgaacttga cgacgaggtg gaactgctgc acgctaccgc 21060 gcccaggcga cgggtacagt ggaaaggtcg acgcgtaaaa cgtgttttgc gacccggcac 21120 ca ccgtagtc tttacgcccg gtgagcgctc cacccgcacc tacaagcgcg tgtatgatga 21180 ggtgtacggc gacgaggacc tgcttgagca ggccaacgag cgcctcgggg agtttgccta 21240 cggaaagcgg cataaggaca tgctggcgtt gccgctggac gag ggcaacc caacacctag 21300 cctaaagccc gtaacactgc agcaggtgct gcccgcgctt gcaccgtccg aagaaaagcg 21360 cggcctaaag cgcgagtctg gtgacttggc acccaccgtg cagctgatgg tacccaagcg 21420 ccagcgactg gaagatgtct tggaaaaaat gaccgtggaa cctgggctgg agcccgaggt 21480 ccgcgtgcgg ccaatcaagc aggtggcgcc gggactgggc gtgcagaccg tggacgttca 21540 gatacccact accagtagca ccagtattgc caccgccaca gagggcatgg agacacaaac 21600 gtccccggtt gcctcagcgg tggcggatgc cgcggtgcag gcggtcgctg cggccgcgtc 21660 caagacctct acggaggtgc aaacggaccc gtggatgttt cgcgtttcag ccccccggcg 21 720 cccgcgccgt tcgaggaagt acggcgccgc cagcgcgcta ctgcccgaat atgccctaca 21780 tccttccatt gcgcctaccc ccggctatcg tggctacacc taccgcccca gaagacgagc 21840 aactacccga cgccgaacca ccactggaac ccgccgccgc cgtcgccgtc gccagcccgt 21900 gctggccccg atttccgtgc gcagggtggc tcgcgaagga ggcaggaccc tggtgctgcc 21960 aacagcgcgc taccacccca gcatcgttta aaagccggtc tttgtggttc ttgcagatat 22020 ggccctcacc tgccgcctcc gtttcccggt gccgggattc cgaggaagaa tgcaccgtag 22080 gaggggcatg gccggccacg gcctgacggg cggcatgcgt cgtgcgcacc accggcggcg 22140 gc gcgcgtcg caccgtcgca tgcgcggcgg tatcctgccc ctccttattc cactgatcgc 22200 cgcggcgatt ggcgccgtgc ccggaattgc atccgtggcc ttgcaggcgc agagacactg 22260 attaaaaaca agttgcatgt ggaaaaatca aaataaaaag tctggactct cacgctcgct 22320 tggtcctgta actattttgt agaatggaag acatcaactt tgcgtctctg gccccgcgac 22380 acggctcgcg cccgttcatg ggaaactggc aagatatcgg caccagcaat atgagcggtg 22440 gcgccttcag ctggggctcg ctgtggagcg gcattaaaaa tttcggttcc accgttaaga 22500 actatggcag caaggcctgg aacagcagca caggccagat gctgagggat aagttgaaag 22560 agcaaaattt ccaacaaaag gtggtagatg gcctggcctc tggcattagc ggggtggtgg 22620 acctggccaa ccaggcagtg caaaataaga ttaacagtaa gcttgatccc cgccctcccg 22680 tagaggagcc tccaccggcc gtggagacag tgtctccaga ggggcgtggc gaaaagcgtc 22740 cgcgccccga cagggaagaa actctggtga cgcaaataga cgagcctccc tcgtacgagg 22800 aggcactaaa gcaaggcctg cccaccaccc gtcccatcgc gcccatggct acc ggaggtgc 22860 tgggccagca cacacccgta acgctggacc tgcctccccc cgccgacacc cagcagaaac 22920 ctgtgctgcc aggcccgacc gccgttgttg taacccgtcc tagccgcgcg tccctgcgcc 22980 gcgccgccag cggtccgcga tcgttgc ggc ccgtagccag tggcaactgg caaagcacac 23040 tgaacagcat cgtgggtctg ggggtgcaat ccctgaagcg ccgacgatgc ttctgatagc 23100 taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag ctgctgagcc 23160 gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg gtcttacatg 23220 cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca gtt tgcccgc 23280 gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt ggcgcctacg 23340 cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc tgtggaccgt 23400 gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga taaccgtgg 23460 ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg ccctactttt 23520 aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc aaatccttgc 23580 gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga cgatgacaac 23640 gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg gcaggcgcct 23700 t attctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg tcaaacacct 23760 aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca gtggtacgaa 23820 acagaaatta atcatgcagc tgggagagtc ctaaaaaaga ctaccccaat gaaaccatgt 23880 tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct tgtaaagcaa 23940 caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac tgaggcagcc 24000 gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga tgtagatata 24060 gaaaccccag acactcatat ttcttacatg cccactatta agggaaggtaa ctcacgagaa 24120 ctaatgggcc aacaatctat gcc caacagg cctaattaca ttgcttttag ggacaatttt 24180 attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg ccaagcatcg 24240 cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata ccagcttttg 24300 ctt gattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc tgttgacagc 24360 tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact tccaaattac 24420 tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa acctaaaaca 24480 ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa tgaaataaga 24540 gttggaaata attttgccat ggaa gtgg actgct acattaacct tggagcacgc tggtcccttg actatatgga caacgtcaac 24780 ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct gggcaatggt 24840 cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccatta aaacctcctt 24900 ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa catggttctg 24960 cagagctccc taggaaatga cctaagggtt gacgg agcca gcattaagtt tgatagcatt 25020 tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct tgaggccatg 25080 cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc cacacatgctc 25140 taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg caactgggcg 25200 gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc actgggctcg c ggggagggt 25440 tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat gctagctaac 25500 tataacattg gctaccaggg cttctatatc ccagagagct acaaggaccg catgtactcc 25560 ttctttagaa acttccagcc catgagccgt caggtggtgg atgatact aa atacaaggac 25620 taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg ctaccttgcc 25680 cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct tataggcaag 25740 accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct ttggcgcatc 25800 ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca aaac cttctc 25860 tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat ggacgagccc 25920 acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcacca gccgcaccgc 25980 ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc cacaacataa 26040 agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag gaactgaaag 26100 ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac aagcgctttc 26160 caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc ggtcgcgaga 26220 ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca tgctacctct 26280 ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt gagtacgagt 26340 cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg ctggaaaagt 26400 ccacccaaag cgtacagggg ccca actcgg ccgcctgtgg actattctgc tgcatgtttc 26460 tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc atgaacctta 26520 ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc ctgcgtcgca 26580 accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc agccacagtg 26640 cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa taatgtacta 26700 gagac acttt caataaaggc aaatgctttt atttgtacac tctcgggtga ttatttaccc 26760 ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca tcgctatgcg 26820 ccactggcag ggacacgttg cgatactggt gtttagtgct ccactta aac tcaggcacaa 26880 ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc accaacgcgt 26940 ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc tgcgcgcgcg 27000 agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg tgcacgctgg 27060 ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg ctcagggcga 27120 acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc tttgagttgc 27180 actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta ggatacagcg 27240 cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct tcagagaaga 27300 acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg tgcacgcagc 27360 accttgcgtc ggtgttggag atctgcacca cattt cggcc ccaccggttc ttcacgatct 27420 tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc acatccattt 27480 caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc tcgccttcga 27540 t ctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc ttgtaggtca 27600 cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc acaaaggtct 27660 tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag gtcttgcata 27720 cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt agatcgttat 27780 ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gccct tctcc cacgcagaca 27840 cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg ctgggctctt 27900 cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc agccgccgca 27960 ctgtgcgctt acctcct ttg ccatgcttga ttagcaccgg tgggttgctg aaacccacca 28020 tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct ggtgatggcg 28080 ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg gccaaatccg 28140 ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct tgtgatgagt 28200 cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc gcccggggag 28260 gcggcggcga cggggacggg gacgacacgt cctccatggt tggggacgt cgcgccgcac 28320 cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc ccgactggcc atttccttct 28380 cctataggca gaaaaagatc atgg agtcag tcgagaagaa ggacagccta accgccccct 28440 ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc ttccccgtcg 28500 aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt tttgtaagcg 28560 aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag gacaacgcag 28620 aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac ctagatgtgg 28680 gagacgacgt gctgtt gaag catctgcagc gccagtgcgc cattatctgc gacgcgttgc 28740 aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac gaacgccacc 28800 tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag cccaacccgc 28860 gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat cacatctttt 28920 tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg gacaagcagc 28980 tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa gtgccaaaaa 29040 tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa caggaaaaca 29100 gcgaa aatga aagtcactct ggaggtgttgg tggaactcga gggtgacaac gcgcgcctag 29160 ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt aacctacccc 29220 ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag cccctgg aga 29280 gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc gacgagcagc 29340 tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc aaactaatga 29400 tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt gctgacccgg 29460 agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc tacgtacgcc 29520 aggcctgcaa gatctccaac gtggagct ct gcaacctggt ctcctacctt ggaattttgc 29580 acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag gcgcgccgcg 29640 actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg gccatgggcg 29700 t ttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg ctaaagcaaa 29760 acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac ctggcggaca ccat taagta ccgcgaatgc cctccgccgc 30000 tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac tctgacataa 30060 tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac ctatgcaccc 30120 cgcaccgct c cctggtttgc aattcgcagc tgcttaacga aagtcaaatt atcggtacct 30180 ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg aaactcactc 30240 cggggctgg gacgtcggct taccttcgca aatttgtacc tgaggactac cacgcccacg 30300 agattaggtt ctacgaagac caatcccgcc cgcctaatgc ggagcttacc gcctgcgtca 30360 ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc caagagtttc 30420 tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag ctcaacccaa 30480 tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc caggatggca 30540 cccaaaaaga agctgcagct gccgcc gcca cccacggacg aggaggaata ctgggacagt 30600 caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg ggagagccta 30660 gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc ctcggtcgca 30720 ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac aacctccgct 30780 cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga cacc ctctaccat c acggcgtggc cttcccccgt 31020 aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg cagcggcagc 31080 aacagcagcg gccacacaga agcaaaggcg accggatagc aagactctga caaagcccaa 31140 gaaatccaca gcggcggcag cagcaggagg aggagcgctg cgtctggcgc ccaacgaacc 31200 cgtatcgacc cgcgagctta gaaacaggat ttttcccact ctgtatgcta tatttcaaca 31260 gagcaggggc caagaacaag agctgaaaat aaaaaacagg tctctgcgat ccctcacccg 31320 cagctgcctg tatcacaaaa gcgaagatca gcttcggcgc acgctggaag acgcggaggc 31380 tctcttcagt aaatactgcg cgctgactct taaggactag tttc gcgccc tttctcaaat 31440 ttaagcgcga aaactacgtc atctccagcg gccacacccg gcgccagcac ctgttgtcag 31500 cgccattatg agcaaggaaa ttcccacgcc ctacatgtgg agttaccagc cacaaatggg 31560 acttgcggct ggagctgccc aagactactc aacccgaata aactacatga gcgcgggacc 31620 ccacatgata tcccgggtca acggaatacg cgcccaccga aaccgaattc tcctggaaca 31680 ggcggctatt accaccacac ctcg taataa ccttaatccc cgtagttggc ccgctgccct 31740 ggtgtaccag gaaagtcccg ctcccaccac tgtggtactt cccagagacg cccaggccga 31800 agttcagatg actaactcag gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc 318 60 gcccgggcag ggtataactc acctgacaat cagagggcga ggtattcagc tcaacgacga 31920 gtcggtgagc tcctcgcttg gtctccgtcc ggacggggaca tttcagatcg gcggcgccgg 31980 ccgctcttca ttcacgcctc gtcaggcaat cctaactctg cagacctcgt cctctgagcc 32040 gcgctctgga ggcattggaa ctctgcaatt tattgaggag tttgtgccat cggtctactt 32100 taaccccttc t cgggacctc ccggccacta tccggatcaa tttattccta actttgacgc 32160 ggtaaaggac tcggcggacg gctacgactg aatgttaagt ggagaggcag agcaactgcg 32220 cctgaaacac ctggtccact gtcgccgcca caagtgcttt gcccgcgact ccgg tgagtt 32280 ttgctacttt gaattgcccg aggatcatat cgagggcccg gcgcacggcg tccggcttac 32340 cgcccaggga gagcttgccc gtagcctgat tcgggagttt acccagcgcc ccctgctagt 32400 tgagcgggac aggggaccct gtgttctcac tgtgatttgc aactgtccta accctggatt 32460 acatcaagat cctctagtta atgtcaggtc gcctaagtcg attaactaga gtacccgggg 32520 atcttattcc ctttaactaa taaaaaaaaa taataaagca tcacttactt aaaatcagtt 32580 agcaaatttc tgtccagttt attcagcagc acctccttgc cctcctccca gctctggtat 32640 tgcagcttcc tcctggctgc aaactttctc cacaatctaa atggaatgtc agtttcctcc 32700 tgttcctgtc cat ccgcacc cactatcttc atgttgttgc agatgaagcg cgcaagaccg 32760 tctgaagata ccttcaaccc cgtgtatcca tatgacacgg aaaccggtcc tccaactgtg aaccttacct cccaaaatgt aaccactgtg 33000 agcccacctc tcaaaaaaac caagtcaaac ataaacctgg aaatatctgc acccctcaca 33060 gttacctcag aagccctaac tgtggctgcc gccgcacctc taatggtcgc gggcaacaca 33120 ctcaccatgc aatcacaggc cccgctaacc gtgcacgact ccaaacttag cattgccacc 33180 caaggacccc tcacagtgtc agaaggaaag ctagccctgc aaacatcagg ccccctcacc 33240 accaccgata gcagtaccct tactatcact gcctcacccc ctctaactac tgccactggt 33300 agcttgggca ttgacttgaa agagcccatt tatacacaaa atggaaaact aggactaaag 33360 tacggggctc ctttgcatgt aacagacgac ctaaacactt tgaccgtagc aactgg tcca 33420 ggtgtgacta ttaataatac ttccttgcaa actaaagtta ctggagcctt gggttttgat 33480 tcacaaggca atatgcaact taatgtagca ggaggactaa ggattgattc tcaaaacaga 33540 cgccttatac ttgatgttag ttatccgttt gatgctca aa accaactaaa tctaagacta 33600 ggacagggcc ctctttttat aaactcagcc cacaacttgg atattaacta caacaaaggc 33660 ctttacttgt ttacagcttc aaacaattcc aaaaagcttg aggttaacct aagcactgcc 33720 aaggggttga tgtttgacgc tacagccata gccattaatg caggagatgg gcttgaattt 33780 ggttcaccta atgcaccaaa cacaaatccc ctcaaaacaa aaattggcca tggcctagaa Atgat ggcaa acttacttta 34020 gttatagtaa aaaatggagg gcttgttaat ggctacgtgt ctctagttgg tgtatcagac 34080 actgtgaacc aaatgttcac acaaaagaca gcaaacatcc aattaagatt atattttgac 34140 tcttctggaa atctattaac tgaggaatca gacttaaaaa ttccacttaa aaataaatct 34200 tctacagcga ccagtgaaac tgtagccagc agcaaagcct ttatgccaag tactacagct 34260 ta tcccttca acaccactac tagggatagt gaaaactaca ttcatggaat atgttactac 34320 atgactagtt atgatagaag tctatttccc ttgaacattt ctataatgct aaacagccgt 34380 atgatttctt ccaatgttgc ctatgccata caatttgaat ggaatctaaa tgcaagtgaa 3 4440 tctccagaaa gcaacatagc tacgctgacc acatccccct ttttcttttc ttacattaca 34500 gaagacgaca actaaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 34560 gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata gcttatacag 34620 atcaccgtac cttaatcaaa ctcacagaac cctagtattc aacctgccac ctccctccca 34680 acacagag tacacagtcc ttt ctccccg gctggcctta aaaagcatca tatcatgggt 34740 aacagacata ttcttaggtg ttatattcca cacggtttcc tgtcgagcca aacgctcatc 34800 agtgatatta ataaactccc cgggcagctc acttaagttc atgtcgctgt ccagctgctg 34860 agccacaggc tgct gtccaa cttgcggttg cttaacgggc ggcgaaggag aagtccacgc 34920 ctacatgggg gtagagtcat aatcgtgcat caggataggg cggtggtgct gcagcagcgc 34980 gcgaataaac tgctgccgcc gccgctccgt cctgcaggaa tacaacatgg cagtggtctc 35040 ctcagcgatg attcgcaccg cccgcagcat aaggcgcctt gtcctccggg cacagcagcg 35100 caccctgatc tcacttaaat cagcacagta actgcagcac agcaccacaa tattgttcaa 35160 aatcccacag tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag aacccacgtg 35220 gccatcatac cacaagcgca ggtagattaa gtggcgaccc ctcataaaca cgctggacat 35 280 aaacattacc tcttttggca tgttgtaatt caccacctcc cggtaccata taaacctctg 35340 attaaacatg gcgccatcca ccaccatcct aaaccagctg gccaaaacct gcccgccggc 35400 tatacactgc agggaaccgg gactggaaca atgacagtgg agagcccagg actcgtaacc 35460 atggatcatc atgctcgtca tgatatcaat gttggcacaa cacaggcaca cgtgcataca 35520 cttcctcagg attacaagct cctcccgcgt tagaaccata tcccagg gaa caacccattc 35580 ctgaatcagc gtaaatccca cactgcaggg aagacctcgc acgtaactca cgttgtgcat 35640 tgtcaaagtg ttacattcgg gcagcagcgg atgatcctcc agtatggtag cgcgggtttc 35700 tgtctcaaaa ggaggtagac gatccctact gt acggagtg cgccgagaca accgagatcg 35760 tgttggtcgt agtgtcatgc caaatggaac gccggacgta gtcatatttc ctgaagcaaa 35820 accaggtgcg ggcgtgacaa acagatctgc gtctccggtc tcgccgctta gatcgctctg 35880 tgtagtagtt gtagtatatc cactctctca aagcatccag gcgccccctg gcttcgggtt 35940 ctatgtaaac tccttcatgc gccgctgccc tgata acatc caccaccgca gaataagcca 36000 cacccagcca acctacacat tcgttctgcg agtcacacac gggaggagcg ggaagagctg 36060 gaagaaccat gttttttttt ttattccaaa agattatcca aaacctcaaa atgaagatct 36120 attaagtgaa cgcgct cccc tccggtggcg tggtcaaact ctacagccaa agaacagata 36180 atggcatttg taagatgttg cacaatggct tccaaaaggc aaacggccct cacgtccaag 36240 tggacgtaaa ggctaaaccc ttcagggtga atctcctcta taaacattcc agcaccttca 36300 accatgccca aataattctc atctcgccac cttctcaata tatctctaag caaatcccga 36360 atattaagtc cggccattgt aaaaatctgc tccagagcgc cctccacctt cag cctcaag 36420 cagcgaatca tgattgcaaa aattcaggtt cctcacagac ctgtataaga ttcaaaagcg 36480 gaacattaac aaaaataccg cgatcccgta ggtcccttcg cagggccagc tgaacataat 36540 cgtgcaggtc tgcacggacc agcgcggcc a cttccccgcc aggaaccatg acaaaagaac 36600 ccacactgat tatgacacgc atactcggag ctatgctaac cagcgtagcc ccgatgtaag 36660 cttgttgcat gggcggcgat ataaaatgca aggtgctgct caaaaaatca ggcaaagcct 36720 cgcgcaaaaa agaaagcaca tcgtagtcat gctcatgcag ataaaggcag gtaagctccg 36780 gaaccaccac agaaaaagac accatttttc tctcaaacat gtctgcgggt ttctgcataa 36840 acacaaaata aaataacaaa aaaacattta aacattagaa gcctgtctta caacaggaaa 36900 aacaaccctt ataagcataa gacggactac ggccatgccg gcgtgaccgt aaaaaaactg 36960 gtcaccgtga ttaaaaagca ccaccgacag ctcctcggt c atgtccggag tcataatgta 37020 agactcggta aacacatcag gttgattcac atcggtcagt gctaaaaagc gaccgaaata 37080 gcccggggga atacataccc gcaggcgtag agacaacatt acagccccca taggaggtat 37140 aacaaaatta ataggagaga aaaacacata aacacctgaa aaaccctcct gcctaggcaa 37200 aatagcaccc tcccgctcca gaacaacata cagcgcttcc acagcggcag ccataacagt 37260 cagccttacc agtaaaaa ag aaaacctatt aaaaaaacac cactcgacac ggcaccagct 37320 caatcagtca cagtgtaaaa aagggccaag tgcagagcga gtatatatag gactaaaaaaa 37380 tgacgtaacg gttaaagtcc acaaaaaca cccagaaaac cgcacgcgaa cctacgccca 3 7440 gaaacgaaag ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt tcccacgtta 37500 cgtcacttcc cattttaaga aaactacaat tcccaaca tacaagttac tccgccctaa 37560 aacctacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc caccccctca 37620ttatcatatt ggcttcaatc caaaataagg tatattattg atgatg 37666 <210> 25 <211> 34727 <212> DNA <213> artificial sequence <220> <223> #2 vector <400> 25 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg t ggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gt gttatca tagcgcgtaa tactgtaata gtaatcaatt 360 acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420 ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt 480 cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540 actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600 aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660 acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720 tacatcaatg ggcgtggata gcggtttgac tcac ggggat ttccaagtct ccaccccatt 780 gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840 aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900 agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960 cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020 agacaccggg accgatccag cctccgattt gccaccatgt ttgtgttcct ggtgctgctg 1080 ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc tcctgcctac 1140 accaactcct tcaccaggggg agtctactac cctgacaagg tgt tcaggtc ctctgtgctg 1200 cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt ccatgccatc 1260 catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc attcaatgat 1320 ggaggtctact ttgccagcac agagaagagc aacatcatca ggggctggat ttttggcacc 1380 accctggaca gcaagaccca gtccctgctg attgtgaaca atgccaccaa tgtggt gatt 1440 aaggtgtgg agttccagtt ctgtaatgac ccattcctgg gagtctacta ccacaagaac 1500 aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa ctgtaccttt 1560 gaatatgtga gccaaccatt cctgatggac ttggagggca agcagg gcaa cttcaagaac 1620 ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag caaacacaca 1680 ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc actggtggac 1740 ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca caggtcctac 1800 ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta ctatgtgg gc 1860 tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat cacagatgct 1920 gtggactgg ccctggaccc actgtctgag accaagtgta ccctgaaatc cttcacagtg 1980 gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag cattgt gagg 2040 tttccaaaca tcaccaacct gtgtccattt ggagaggtgt tcaatgccac caggtttgcc 2100 tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta ctctgtgctc 2160 tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac caaactgaat 2220 gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga tgaggtgaga 22 80 cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact gcctgatgac 2340 ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt gggaggcaac 2400 tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga gagggacatc 2460 agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg cttcaactgt 2520 tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta ccaaccatac 2580 agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgg tggaccaaag 2640 aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg actgacaggc 2700 acaggagtgc tgacagagag caacaagaag tcctgccat tccaacagtt tggcagggac 2760 attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct ggacatcaca 2820 ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag caaccaggtg 2880 gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca tgctgaccaa 2940 cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac cagggctggc 3000 tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc aattggagca 3060 ggcatctgg cctcctacca gacccagacc atcctcaggt ctgtggcaag ccagagcatc 3120 attgcctaca caatgagtct gggag cagag aactctgtgg cttacagcaa caacagcatt 3180 gccatcccaa ccaacttcac catctctgtg accacagaga ttctgcctgt gagtatgacc 3240 aagacctctg tggactgtac aatgtatatc tgtggagaca gcacagagtg tagcaacctg 3300 ctgctccaat atggctcctt ctgtacc caa cttaacaggg ctctgacagg cattgctgtg 3360 gaacaggaca agaacaccca ggaggtgttt gcccaggtga agcagattta caagacacct 3420 ccaatcaagg actttggagg cttcaacttc agccagattc tgcctgaccc aagcaagcca 3480 agcaagaggt ccttcattga ggacctgctg ttcaacaagg tgaccctggc tgatgctggc 3540 ttcatcaagc aatatggaga ctgt ctggga gacattgctg ccagggacct gatttgtgcc 3600 cagaagttca atggactgac agtgctgcct ccactgctga cagatgagat gattgcccaa 3660 tacacctctg ccctgctggc tggcaccatc acctctggct ggacctttgg agcaggagca 3720 gccctccaaa tcccattt gc tatgcagatg gcttacaggt tcaatggcat tggagtgacc 3780 cagaatgtgc tctatgagaa ccagaaactg attgccaacc agttcaactc tgccattggc 3840 aagattcagg actccctgtc cagcacagcc tctgccctgg gcaaactcca agatgtggtg 3900 aaccagaatg cccaggctct gaacaccctg gtgaagcaac tttccagcaa ctttggagcc 3960 atctcctctg tgctgaatga catcctgagc agactggaca a ggtggaggc tgaggtccag 4020 attgacagac tgattacagg cagactccaa tccctccaaa cctatgtgac ccaacaactt 4080 atcagggctg ctgagattag ggcatctgcc aacctggctg ccaccaagat gagtgagtgt 4140 gtgctgggac aaagcaagag ggtggacttc t gtggcaagg gctaccacct gatgagtttt 4200 ccacagtctg cccctcatgg agtggtgttc ctgcatgtga cctatgtgcc tgcccaggag 4260 aagaacttca ccacagcccc tgccatctgc catgatggca aggctcactt tccaagggag 4320 ggaggtgtttg tgagcaatgg cacccactgg tttgtgaccc agaggaactt ctatgaacca 4380 cagattatca ccacagacaa cacctttgtg tctggcaact gtgatgtggt gattggcatt 4440 gtgaacaaca cagtctatga cccactccaa cctgaactgg actccttcaa ggaggaactg 4500 gacaaatact tcaagaacca caccagccct gatgtggacc tgggagacat ctctggcatc 4560 aatgcctctg tggtgaacat ccagaaggag attgacagac tgaatgaggt ggctaagaac 4620 ctgaatgagt ccctgattga cctccaagaa ctgggcaaat atgaacaata catcaagtgg 4680 ccatgaaaat tgatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 4740 aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 4800 ttgttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 4860 aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttaa 4920 cgcggatctg ggcgtggtta agggtgggaa agaatatata aggtgggggt cttatgtagt 4980 tttgtatctg ttttgcagca gccgccgccg ccatgagc ac caactcgttt gatggaagca 5040 ttgtgagctc atatttgaca acgcgcatgc ccccatgggc cggggtgcgt cagaatgtga 5100 tgggctccag cattgatggt cgccccgtcc tgcccgcaaa ctctactacc ttgacctacg 5160 agaccgtgtc tggaacgccg ttggagactg cagcctccgc cgccgcttca gccgctgcag 5220 ccaccgcccg cgggattgtg actgactttg ctttcctgag cccgcttgca a gcagtgcag 5280 cttcccgttc atccgcccgc gatgacaagt tgacggctct tttggcacaa ttggattctt 5340 tgacccggga acttaatgtc gtttctcagc agctgttgga tctgcgccag caggtttctg 5400 ccctgaaggc ttcctcccct cccaatgcgg tttaaaacat aaataaaaaa ccagactctg 5460 tttggatttg gatcaagcaa gtgtcttgct gtctttattt aggggttttg cgcgcgcggt 5520 aggcccggga ccagcggtct cggtcgttga gggtcctgtg tattttttcc aggacgtggt 5580 aaaggtgact ctggatgttc agatacatgg gcataagccc gtctctgggg tggaggtagc 5640 accactgcag agcttcatgc tgcggggtgg tgttgtagat gatccagtcg tagcaggagc 5700 gctggg cgtg gtgcctaaaa atgtctttca gtagcaagct gattgccagg ggcaggccct 5760 tggtgtaagt gtttacaaag cggttaagct gggatgggtg catacgtggg gatatgagat 5820 gcatcttgga ctgtattttt aggttggcta tgttcccagc catatccctc cggggattca 5880 tgttgtgcag aaccaccagc acagtgtatc cggtgcactt gggaaatttg tcatgtagct 5940 tagaaggaaa tgcgtggaag aacttggaga cgcccttgtg acctccaaga ttttccatgc 6000 attcgtccat aatgatggca atgggcccac gggcggcggc ctgggcgaag atatttctgg 6060 gatcactaac gtcatagttg tgttccagga tgagatcgtc ataggccatt tttacaaagc 6120 gcgggcggag ggt gccagac tgcggtataa tggttccatc cggcccaggg gcgtagttac 6180 cctcacagat ttgcatttcc cacgctttga gttcagatgg ggggatcatg tctacctgcg 6240 gggcgatgaa gaaaacggtt tccggggtag ggggagatcag ctgggaagaa agcaggtt cc 6300 tgagcagctg cgacttaccg cagccggtgg gcccgtaaat cacacctatt accggctgca 6360 actggtagtt aagagagctg cagctgccgt catccctgag caggggggcc acttcgttaa 6420 gcatgtccct gactcgcatg ttttccctga ccaaatccgc cagaaggcgc tcgccgccca 6480 gcgatagcag ttcttgcaag gaagcaaagt ttttcaacgg tttgagaccg tccgccgtag 6540 gcatgctttt gagc gtttga ccaagcagtt ccaggcggtc ccacagctcg gtcacctgct 6600 ctacggcatc tcgatccagc atatctcctc gtttcgcggg ttggggcggc tttcgctgta 6660 cggcagtagt cggtgctcgt ccagacgggc cagggtcatg tctttccacg gg cgcagggt 6720 cctcgtcagc gtagtctggg tcacggtgaa ggggtgcgct ccgggctgcg cgctggccag 6780 ggtgcgcttg aggctggtcc tgctggtgct gaagcgctgc cggtcttcgc cctgcgcgtc 6840 ggccaggtag catttgacca tggtgtcata gtccagcccc tccgcggcgt ggcccttggc 6900 gcgcagcttg cccttggagg aggcgccgca cgaggggcag tgcagacttt tgagggcgta 6960 gagcttgggc gcgagaaata ccg attccgg ggagtaggca tccgcgccgc aggccccgca 7020 gacggtctcg cattccacga gccaggtgag ctctggccgt tcggggtcaa aaaccaggtt 7080 tcccccatgc tttttgatgc gtttcttacc tctggtttcc atgagccggt gtccacgctc 7140 ggtgacgaaa aggctgtccg tgtccccgta tacagacttg agaggcctgt cctcgagcgg 7200 tgttccgcgg tcctcctcgt atagaaactc ggaccactct gagacaaagg ctcgcgtcca 7260 ggccagcacg aaggaggcta agtgggaggg gtagcggtcg ttgtccacta gggggtccac 7320 tcgctccagg gtgtgaagac acatgtcgcc ctcttcggca tcaaggaagg tgattggttt 7380 gtaggtgtag gccacgtgac cgggtgttcc tgaagggggg ct ataaaagg gggtgggggc 7440 gcgttcgtcc tcactctctt ccgcatcgct gtctgcgagg gccagctgtt ggggtgagta 7500 ctccctctga aaagcgggca tgacttctgc gctaagattg tcagtttcca aaaacgagga 7560 ggatttgata ttcacctgg c ccgcggtgat gcctttgagg gtggccgcat ccatctggtc 7620 agaaaagaca atctttttgt tgtcaagctt ggtggcaaac gacccgtaga gggcgttgga 7680 cagcaacttg gcgatggagc gcagggtttg gtttttgtcg cgatcggcgc gctccttggc 7740 cgcgatgttt agctgcacgt attcgcgcgc aacgcaccgc cattcgggaa agacggtggt 7800 gcgctcgtcg ggcaccaggt gcacgcgcca accg cggttg tgcagggtga caaggtcaac 7860 gctggtggct acctctccgc gtaggcgctc gttggtccag cagaggcggc cgcccttgcg 7920 cgagcagaat ggcggtaggg ggtctagctg cgtctcgtcc ggggggtctg cgtccacggt 7980 aaagaccccg ggcagcagg c gcgcgtcgaa gtagtctatc ttgcatcctt gcaagtctag 8040 cgcctgctgc catgcgcggg cggcaagcgc gcgctcgtat gggttgagtg ggggacccca 8100 tggcatgggg tgggtgagcg cggaggcgta catgccgcaa atgtcgtaaa cgtagagggg 8160 ctctctgagt attccaagat atgtagggta gcatcttcca ccgcggatgc tggcgcgcac 8220 gtaatcgtat agttcgtgcg agggagcgag gaggtcggga ccgaggttgc tacgg gcggg 8280 ctgctctgct cggaagacta tctgcctgaa gatggcatgt gagttggatg atatggttgg 8340 acgctggaag acgttgaagc tggcgtctgt gagacctacc gcgtcacgca cgaaggaggc 8400 gtaggagtcg cgcagcttgt tgaccagctc ggcggtgacc tgcacgtcta gggcgcagta 8460 gtccagggtt tccttgatga tgtcatactt atcctgtccc ttttttttcc acagctcgcg 8520 gttgaggaca aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc 8580 cgaacggtaa gagcctagca tgtagaactg gttgacggcc tggtaggcgc agcatccctt 8640 ttctacgggt agcgcgtatg cctgcgcggc cttccggagc gaggtgtggg tgagcgcaaa 8700 ggtgtccctg accatgactt tgaggtactg gtatttgaag tcagtgtcgt cgcatccgcc 8760 ctgctcccag agcaaaaagt ccgtgcgctt tttggaacgc ggatttggca gggcgaaggt 8820 gacatcgttg aagagtatct ttcccgcgcg agga ag ttgcgtgtga tgcggaaggg 8880 tcccggcacc tcggaacggt tgttaattac ctgggcggcg agcacgatct cgtcaaagcc 8940 gttgatgttg tggcccacaa tgtaaagttc caagaagcgc gggatgccct tgatggaagg 9000 caatttttta agttcctcgt aggtgagctc ttcaggggag ctgagcccgt gctctgaaag 9060 ggcccagtct gcaagatgag ggttggaagc gacgaatgag ctccacaggt cacgggccat 9120 tagcatttgc agg tggtcgc gaaaggtcct aaactggcga cctatggcca ttttttctgg 9180 ggtgatgcag tagaaggtaa gcgggtcttg ttcccagcgg tcccatccaa ggttcgcggc 9240 taggtctcgc gcggcagtca ctagaggctc atctccgccg aacttcatga ccagcatga a 9300 gggcacgagc tgcttcccaa aggcccccat ccaagtatag gtctctacat cgtaggtgac 9360 aaagagacgc tcggtgcgag gatgcgagcc gatcgggaag aactggatct cccgccacca 9420 attggaggag tggctattga tgtggtgaaa gtagaagtcc ctgcgacggg ccgaacactc 9480 gtgctggctt ttgtaaaaac gtgcgcagta ctggcagcgg tgcacgggct gtacatcctg 9540 cacgaggttg acctgac gac cgcgcacaag gaagcagagt gggaatttga gcccctcgcc 9600 tggcgggttt ggctggtggt cttctacttc ggctgcttgt ccttgaccgt ctggctgctc 9660 gaggggagtt acggtggatc ggaccaccac gccgcgcgag cccaaagtcc agatgtccgc 9 720 gcgcggcggt cggagcttga tgacaacatc gcgcagatgg gagctgtcca tggtctggag 9780 ctcccgcggc gtcaggtcag gcgggagctc ctgcaggttt acctcgcata gacgggtcag 9840 ggcgcgggct agatccaggt gatacctaat ttccaggggc tggttggtgg cggcgtcgat 9900 ggcttgcaag aggccgcatc cccgcggcgc gactacggta ccgcgcggcg ggcggtgggc 9960 cgcgggggtg tccttggatg at gcatctaa aagcggtgac gcgggcgagc ccccggaggt 10020 aggggggggct ccggacccgc cgggagaggg ggcaggggca cgtcggcgcc gcgcgcgggc 10080 aggagctggt gctgcgcgcg taggttgctg gcgaacgcga cgacgcggcg gttgatctcc 10140 tgaatctggc gcctctgcgt gaagacgacg ggcccggtga gcttgaacct gaaagagagt 10200 tcgacagaat caatttcggt gtcgttgacg gcggcctggc gcaaaatctc ctgcacgtct 10260 cctgagttgt cttgataggc gatctcggcc atgaactgct cgatctcttc ctcctggaga 10320 tctccgcgtc cggctcgctc cacggtggcg gcgaggtcgt tggaaatgcg ggccatgagc 10380 tgcgagaagg cgttgaggcc tccctcgttc cagacgcggc tgtagaccac gcccccttcg 10440 gcatcgcggg cgcgcatgac cacctgcgcg agattgagct ccacgtgccg ggcgaagacg 10500 gcgtagtttc gcaggcgctg aaagaggtag ttgagggtgg tggcggtgtg ttctgccacg 10560 aagaagtaca taacccagcg tcgcaacgtg gattcgttga tatcccccaa ggcctcaagg 10620 cgctccatgg cctcgtagaa gtccacggcg aagttgaaaa actgggagtt gcgcgccgac 10680 acggttaact cctcctccag aagacggatg agctcggcga cagtgtcgcg cacctcgcgc 10740 tcaaaggcta caggggcctc ttcttcttct tcaatctcct cttccataag ggcctcccct 10800 tcttcttctt ctggcggcgg tgggggaggg gggacacggc ggcgacgacg gcgcaccggg 10860 aggcggtcga caaagcgctc gatcatctcc ccgcggcgac ggcgcatggt ctcggtgacg 10920 gcgcggccgt tctcgcgggg gcgcagttgg aagacgccgc ccgtcatgtc ccggttatgg 10980 gttggcgg gg ggctgccatg cggcagggat acggcgctaa cgatgcatct caacaattgt 11040 tgtgtaggta ctccgccgcc gagggacctg agcgagtccg catcgaccgg atcggaaaac 11100 ctctcgagaa aggcgtctaa ccagtcacag tcgcaaggta ggctgagcac cgtggcgggc 11160 ggcagcgggc ggcggtcggg gttgtttctg gcggaggtgc tgctgatgat gtaattaaag 11220 taggcggtct tgagacggcg gatggtcgac agaagcacca tgt ccttggg tccggcctgc 11280 tgaatgcgca ggcggtcggc catgccccag gcttcgtttt gacatcggcg caggtctttg 11340 tagtagtctt gcatgagcct ttctaccggc acttcttctt ctccttcctc ttgtcctgca 11400 tctcttgcat ctatcgctgc ggcggcggcg gagtttggcc gtaggtggcg ccctcttcct 11460 cccatgcgtg tgaccccgaa gcccctcatc ggctgaagca gggctaggtc ggcgacaacg 11520 cgctcggcta atatggcctg ctgcacctgc gtgagggtag actggaagtc atccatgtcc 11580 acaaagcggt ggtatgcgcc cgtgttgatg gtgtaagtgc agttggccat aacggaccag 11640 ttaacggtct ggtgacccgg ctgcgagagc tcggtgtacc tgagacgcga gtaagccctc 11700 gagtcaaata cgtagtcgtt gcaagtccgc accaggtact ggtatcccac caaaaagtgc 11760 ggcggcggct ggcggtagag gggccagcgt agggtggccg gggctccggg ggcgagatct 11820 tccaacataa ggcgatgata tccgtagatg tacctggaca tccaggtgat gccggcggcg 11880 gtggtggagg cgcgcggaaa gtcgcggacg cggttccaga tgttgcgcag cggcaaaaag 11940 tgctccatgg tcgggacgct ctggccggtc aggcgcgcgc aatcgttgac gctctagcgt 12000 gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa ttcgcaaggg 12060 tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt gatccatgcg 12120 g ttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga gtgctccttt 12180 tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg gccgcgcgca 12240 gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc t cgctccctg tagccggagg 12300 gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc ggccggactg 12360 cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt cctccggaaa 12420 cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc agatgcgccc 12480 ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac cctcccctcc 12540 tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg gtgattacga 12600 acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg gcctggcgcg 12660 gctaggagcg ccctctcctg agcggcaccc aagggtgcag ctgaagcgtg atac gcgtga 12720 ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc ccgaggagat 12780 gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt 12840 gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca 12900 cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg agattaactt 12960 tcaaaaaagc tttaacacacc acgt gcgtac gcttgtggcg cgcgaggagg tggctatagg 13020 actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata gcaagccgct 13080 catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat tcagggatgc 13140 gctgctaa ac atagtagagc ccgagggccg ctggctgctc gatttgataa acatcctgca 13200 gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg ccatcaacta cgagc gcatc cacaaggccg tgagcgtgag 13440 ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg ccctggctgg 13500 cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg acctgcgctg 13560 ggccccaag c cgacgcgccc tggaggcagc tggggccgga cctgggctgg cggtggcacc 13620 cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg agtacgagcc 13680 agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac 13740 ccggcggtgc ggggcggcgct gcagagccag ccgtccggcc ttaactccac ggacgactgg 13800 cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc gttccggcag 13860 cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac 13920 cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg 13980 cccgacgagg ccggcctggt ctac gacgcg ctgcttcagc gcgtggctcg ttacaacagc 14040 ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag 14100 cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa cgccttcctg 14160 agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt tgtgagcgca 14220 ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg gccagact at 14280 tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc tttcaaaaac 14340 ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg 14400 ctgacgccca actcgcgcct gttgct gctg ctaatagcgc ccttcacgga cagtggcagc 14460 gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc cataggtcag 14520 gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc gctggggcag 14580 gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg gcggcagaag 14640 atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta cgtgca gcag 14700 agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc 14760 gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg 14820 gactacttgc atcgcgcggc cgccgtgaac ccc gagtatt tcaccaatgc catcttgaac 14880 ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc cgagggtaac 14940 gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc gcagaccctg 15000 ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg 15060 ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag tagcccattt 15120 cca agcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct gctgggcgag 15180 gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca 15240 tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa gacgtacgc g 15300 caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt 15360 cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt cctggatttg 15420 ggaggggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat gttttaaaaa 15480 aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag cgttggtttt 15540 cttgtatt cc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct 15600 acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc ttcgatgctc 15660 ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg agaa acagca 15720 tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg gtggacaaca 15780 agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt ctgaccacgg 15840 tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc aatcttgacg 15900 accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg ccaaatgtga 15960 acgagttcat gtttaccaat aagtttaagg cgcgg gtgat ggtgtcgcgc ttgcctacta 16020 aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc gagggcaact 16080 actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac tacttgaaag 16140 tgggcagaca gaacggggt t ctggaaagcg acatcggggt aaagtttgac acccgcaact 16200 tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat acaaacgaag 16260 ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc cacagccgcc 16320 tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt aggatcacct 16380 acgatgatct ggaggggtggt aacattcccg cactgttgga tgtggacgcc taccaggcga 16440 gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac agcagtggca 16500 gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg gaggacatga 16560 acgatcatgc cattcgcggc gacacc tttg ccacacgggc tgaggagaag cgcgctgagg 16620 ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga 16680 agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac aacctaataa 16740 gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac tacggcgacc 16800 ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc t gcggctcgg 16860 agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc cgctccacgc 16920 gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct 16980 tctacaacga ccaggccgtc tactcc caac tcatccgcca gtttacctct ctgacccacg 17040 tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc accatcacca 17100 ccgtcagtga t gagcaagca 17280 tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc ccaagcaaga 17340 tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc gggcactacc 17400 gcgcgccctg gggcgcgcac aaacgcgg cc gcactgggcg caccaccgtc gatgacgcca 17460 tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca gtgtccacag 17520 tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac 17580 ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg 17640 cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg cgggccgct c 17700 gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga gcggccgccg 17760 cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg tattgggtgc 17820 gcgactcggt tagcggcctg cgcgtgcccg tg cgcacccg ccccccgcgc aactagattg 17880 caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg 17940 aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg ccggagatct 18000 atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag cgggtcaaaa 18060 agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg cacgctaccg 18120 cgcccaggcg ac gggtacag tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca 18180 ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg 18240 aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg ga gtttgcct 18300 acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac ccaacaccta 18360 gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc 18420 gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg gtacccaagc 18480 gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg 18540 tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc gtggacgttc 18600 agatacccac taccagtagc accagtattg ccaccgccac agagggcatg gagacacaaa 18660 cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct gcggccgc gt 18720 ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca gccccccggc 18780 gcccgcgccg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa cgcagggtgg ctc gcgaagg aggcaggacc ctggtgctgc 19020 caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt cttgcagata 19080 tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta 19140 gga ggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc 19200 ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttat ccactgatcg 19260 ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg cagagacact 19320 gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc 19380 ttggtcctgt aactattttg tagaatg gaa gacatcaact ttgcgtctct ggccccgcga 19440 cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa tatgagcggt 19500 ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc caccgttaag 19560 aactat ggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga taagttgaaa 19620 gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag cggggtggtg 19680 gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc ccgccctccc 19740 gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt 19800 ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc ctcgtacga g 19860 gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc taccggagtg 19920 ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac ccagcagaaa 19980 cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc 20040 cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca 20100 ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg cttctgatag 20160 ctaacgtgtc gtatgtgtgt catgtatgcg tccatgtcgc cgccagagga gctgctgagc 20220 cgccgcgcgc ccgctttcca agatggctac cccttcgatg atgccgcagt ggtcttacat 20280 gcacatctcg ggccaggacg cctcggagta cctgagcccc gggctggtgc agtttgcccg 20340 cgccaccgag acgtacttca gcctgaataa caagtttaga aaccccacgg tggcgcctac 20400 gcacgacgtg accacagacc ggtcccagcg t ttgacgctg cggttcatcc ctgtggaccg 20460 tgaggatact gcgtactcgt acaaggcgcg gttcacccta gctgtgggtg ataaccgtgt 20520 gctggacatg gcttccacgt actttgacat ccgcggcgtg ctggacaggg gccctacttt 20580 taagccctac tctggcactg cctacaacgc cctggctccc aagggtgccc caaatccttg 20640 cgaatgggat gaagctgcta ctgctcttga aataaaccta gaagaagagg acgatgacaa 20700 cgaaga cgaa gtagacgagc aagctgagca gcaaaaaact cacgtatttg ggcaggcgcc 20760 ttattctggt ataaatatta caaaggaggg tattcaaata ggtgtcgaag gtcaaacacc 20820 taaatatgcc gataaaacat ttcaacctga acctcaaata ggagaatctc agtggtacga 2 0880 aacagaaatt aatcatgcag ctgggagagt cctaaaaaag actaccccaa tgaaaccatg 20940 ttacggttca tatgcaaaac ccacaaatga aaatggaggg caaggcattc ttgtaaagca 21000 acaaaatgga aagctagaaa gtcaagtgga aatgcaattt ttctcaacta ctgaggcagc 21060 cgcaggcaat ggtgataact tgactcctaa agtggtattg tacagtgaag atgtagatat 21120 agaaacccca gac actcata tttcttacat gcccactatt aaggaaggta actcacgaga 21180 actaatgggc caacaatcta tgcccaacag gcctaattac attgctttta gggacaattt 21240 tattggtcta atgtattaca acagcacggg taatatgggt gttctggcgg gccaagcatc 21300 gcagttgaat gctgtt gtag atttgcaaga cagaaacaca gagctttcat accagctttt 21360 gcttgattcc attggtgata gaaccaggta cttttctatg tggaatcagg ctgttgacag 21420 ctatgatcca gatgttagaa ttattgaaaa tcatggaact gaagatgaac ttccaaatta 21480 ctgctttcca ctgggaggtg tgattaatac agagactctt accaaggtaa aacctaaaac 21540 aggtcaggaa aat ggatggg aaaaagatgc tacagaattt tcagataaaa atgaaataag 21600 agttggaaat aattttgcca tggaaatcaa tctaaatgcc aacctgtgga gaaatttcct 21660 gtactccaac atagcgctgt atttgcccga caagctaaag tacagtcctt ccaacgtaa a 21720 aatttctgat aacccaaaca cctacgacta catgaacaag cgagtggtgg ctcccgggct 21780 agtggactgc tacattaacc ttggagcacg ctggtccctt gactatatgg c ctacgagg gaacttcagg aaggatgtta acatggttct 22020 gcagagctcc ctaggaaatg acctaagggt tgacggagcc agcattaagt ttgatagcat 22080 ttgcctttac gccaccttct tccccatggc ccacaacacc gcctccacgc ttgaggccat 22140 gcttagaaac gacaccaacg accagtcctt taacgactat ctctccgccg ccaacatgct 22200 ctaccctata cccgccaacg ctaccaacgt gcccatatcc atcccctccc gcaactgggc 22260 ggctttccgc ggctgggcct tcacgcgcct taagactaag gaaaccccat cactgggctc 22320 gggctacgac ccttattaca cctactctgg ctctataccc tacctagatg gaacctttta 22380 cctcaaccac acctttaaga aggtggccat tacctttgac tcttctgtca gctggcctgg 22440 caatgaccgc ctgcttaccc ccaacgagtt tgaaattaag cgctcagttg acggggaggg 22500 ttacaacgtt gcccagtgta acatgaccaa agactggttc ctggtacaaa tgctagctaa 22560 ctataacatt ggctaccagg gcttctatat cccaga gagc tacaaggacc gcatgtactc 22620 cttctttaga aacttccagc ccatgagccg tcaggtggtg gatgatacta aatacaagga 22680 ctaccaacag gtgggcatcc tacaccaaca caacaactct ggatttgttg gctaccttgc 22740 ccccaccatg cgcgaaggac aggcctaccc tgctaacttc ccctatccgc ttataggcaa 22800 gaccgcagtt gacagcatta cccagaaaaa gtttctttgc gatcgcac cc tttggcgcat 22860 cccattctcc agtaacttta tgtccatggg cgcactcaca gacctgggcc aaaaccttct 22920 ctacgccaac tccgcccacg cgctagacat gacttttgag gtggatccca tggacgagcc 22980 cacccttctt tatgttttgt ttgaagt ctt tgacgtggtc cgtgtgcacc agccgcaccg 23040 cggcgtcatc gaaaccgtgt acctgcgcac gcccttctcg gccggcaacg ccacaacata 23100 aagaagcaag caacatcaac aacagctgcc gccatgggct ccagtgagca ggaactgaaa 23160 gccattgtca aagatcttgg ttgtgggcca tattttttgg gcacctatga caagcgcttt 23220 ccaggctttg tttctccaca caagctcgcc tgcgccatag tcaatacggc cggt cgcgag 23280 actgggggcg tacactggat ggcctttgcc tggaacccgc actcaaaaac atgctacctc 23340 tttgagccct ttggcttttc tgaccagcga ctcaagcagg tttaccagtt tgagtacgag 23400 tcactcctgc gccgtagcgc catt gcttct tcccccgacc gctgtataac gctggaaaag 23460 tccaccaaa gcgtacaggg gcccaactcg gccgcctgg gactattctg ctgcatgttt 23520 ctccacgcct ttgccaactg gccccaaact cccatggatc acaaccccac catgaacctt 23580 attaccgggg tacccaactc catgctcaac agtccccagg tacagcccac cctgcgtcgc 23640 aaccaggaac agctctacag cttcctggag cgccactcgc cctacttccg cagccacagt 23700 gcgcagatta ggag cgccac ttctttttgt cacttgaaaa acatgtaaaa ataatgtact 23760 agagacactt tcaataaagg caaatgcttt tatttgtaca ctctcgggtg attatttacc 23820 cccacccttg ccgtctgcgc cgtttaaaaa tcaaaggggt tctgccgcgc atc gctatgc 23880 gccactggca gggacacgtt gcgatactgg tgtttagtgc tccacttaaa ctcaggcaca 23940 accatccgcg gcagctcggt gaagttttca ctccacaggc tgcgcaccat caccaacgcg 24000 tttagcaggt cgggcgccga tatcttgaag tcgcagttgg ggcctccgcc ctgcgcgcgc 24060 gagttgcgat acacagggtt gcagcactgg aacactatca gcgccgggtg gtgcacgctg 2412 0 gccagcacgc tcttgtcgga gatcagatcc gcgtccaggt cctccgcgtt gctcagggcg 24180 aacggagtca actttggtag ctgccttccc aaaaagggcg cgtgcccagg ctttgagttg 24240 cactcgcacc gtagtggcat caaaaggtga ccgtgcccgg tct gggcgtt aggatacagc 24300 gcctgcataa aagccttgat ctgcttaaaa gccacctgag cctttgcgcc ttcagagaag 24360 aacatgccgc aagacttgcc ggaaaactga ttggccggac aggccgcgtc gtgcacgcag 24420 caccttgcgt cggtgttgga gatctgcacc acatttcggc cccaccggtt cttcacgatc 24480 ttggccttgc tagactgctc cttcagcgcg cgctgcccgt tttcgctcgt cacatccatt 24540 tcaat cacgt gctccttatt tatcataatg cttccgtgta gacacttaag ctcgccttcg 24600 atctcagcgc agcggtgcag ccacaacgcg cagcccgtgg gctcgtgatg cttgtaggtc 24660 acctctgcaa acgactgcag gtacgcctgc aggaatcgcc ccatcatcgt caca aaggtc 24720 ttgttgctgg tgaaggtcag ctgcaacccg cggtgctcct cgttcagcca ggtcttgcat 24780 acggccgcca gagcttccac ttggtcaggc agtagtttga agttcgcctt tagatcgtta 24840 tccacgtggt acttgtccat cagcgcgcgc gcagcctcca tgcccttctc ccacgcagac 24900 acgatcggca cactcagcgg gttcatcacc gtaatttcac tttccgcttc gctgggctct 24960 tcctcttcct cttgcgtccg cataccacgc gccactgggt cgtcttcatt cagccgccgc 25020 actgtgcgct tacctccttt gccatgcttg attagcaccg gtgggttgct gaaacccacc 25080 atttgtagcg ccacatcttc tctttcttcc tcgctgtcca cgattacctc tggtgatggc 25140 gggcgctcgg gcttgggaga agggcgcttc ttttcttct tgggcgcaat ggccaaatcc 25200 gccgccgagg tcgatggccg cgggctgggt gtgcgcggca ccagcgcgtc ttgtgatgag 25260 tcttcctcgt cctcggactc gatacgccgc ctcatccgct ttttggggg cgcccgggga 25320 ggcggcggcg acggggacgg ggacgacacg tcctccatgg ttgggggacg tcgcgccgca 25380 ccgcgtccgc gctcgggggt ggt ttcgcgc tgctcctctt cccgactggc catttccttc 25440 tcctataggc agaaaaagat catggagtca gtcgagaaga aggacagcct aaccgccccc 25500 tctgagttcg ccaccaccgc ctccaccgat gccgccaacg cgcctaccac cttccccgtc 25 560 gaggcacccc cgcttgagga ggaggaagtg attatcgagc aggacccagg ttttgtaagc 25620 gaagacgacg aggaccgctc agtaccaaca gaggataaaa agcaagacca ggacaacgca 25680 gaggcaaacg aggaacaagt cgggcggggg gacgaaaggc atggcgacta cctagatgtg 25740 ggagacgacg tgctgttgaa gcatctgcag cgccagtgcg ccattatctg cgacgcgttg 25800 caagagcgca gcgatgtgcc cctcgccata gcggatgtca gcc ttgccta cgaacgccac 25860 ctattctcac cgcgcgtacc ccccaaacgc caagaaaacg gcacatgcga gcccaacccg 25920 cgcctcaact tctaccccgt atttgccgtg ccagaggtgc ttgccaccta tcacatcttt 25980 ttccaaaact gcaagata cc cctatcctgc cgtgccaacc gcagccgagc ggacaagcag 26040 ctggccttgc ggcagggcgc tgtcatacct gatatcgcct cgctcaacga agtgccaaaa 26100 atctttgagg gtcttggacg cgacgagaag cgcgcggcaa acgctctgca acaggaaaac 26160 agcgaaaatg aaagtcactc tggagtgttg gtggaactcg agggtgacaa cgcgcgccta 26220 gccgtactaa aacgcagcat cgaggtcacc cactttgcct acccggcact taacct accc 26280 cccaaggtca tgagcacagt catgagtgag ctgatcgtgc gccgtgcgca gcccctggag 26340 agggatgcaa atttgcaaga acaaacagag gagggcctac ccgcagttgg cgacgagcag 26400 ctagcgcgct ggcttcaaac gcgcgagcct gccg acttgg aggagcgacg caaactaatg 26460 atggccgcag tgctcgttac cgtggagctt gagtgcatgc agcggttctt tgctgacccg 26520 gagatgcagc gcaagctaga ggaaacattg cactacacct ttcgacaggg ctacgtacgc 26580 caggcctgca agatctccaa cgtggagctc tgcaacctgg tctcctacct tggaattttg 26640 cacgaaaacc gccttgggca aaacgtgctt cattccacgc tcaagggcga ggcgcgccg c 26700 gactacgtcc gcgactgcgt ttattattt ctatgctaca cctggcagac ggccatgggc 26760 gtttggcagc agtgcttgga ggagtgcaac ctcaaggagc tgcagaaact gctaaagcaa 26820 aacttgaagg acctatggac ggccttcaac gagcgctccg tggccgcgca cctggcggac 26880 atcattttcc ccgaacgcct gcttaaaacc ctgcaacagg gtctgccaga cttcaccagt 26940 caaagcatgt tgcagaactt taggaacttt atcctagagc gctcaggaat cttgcccgcc 27000 acctgctgtg cacttcctag cgactttgtg cccattaagt accgcgaatg ccctccgccg 27060 ctttggggcc actgctacct tctgcagcta gccaactacc ttgcctacca ctctgacata 27120 atggaagacg tga gcggtga cggtctactg gagtgtcact gtcgctgcaa cctatgcacc 27180 ccgcaccgct ccctggtttg caattcgcag ctgcttaacg aaagtcaaat tatcggtacc 27240 cggag cttac cgcctgcgtc 27420 attacccagg gccacattct tggccaattg caagccatca acaaagcccg ccaagagttt 27480 ctgctacgaa agggacgggg ggtttacttg gacccccagt ccggcgagga gctcaaccca 27540 atccccccgc cgccgcagcc ctatcagca g cagccgcggg cccttgcttc ccaggatggc 27600 acccaaaaag aagctgcagc tgccgccgcc acccacggac gaggaggaat actgggacag 27660 tcaggcagag gaggttttgg acgaggagga ggaggacatg atggaagact gggagagcct 27720 agacgaggaa gcttccgagg tcgaagaggt gtcagacgaa acaccgtcac cctcggtcgc 27780 attcccctcg ccggcgcccc agaaatcggc aaccggttcc agcatggcta caacctcc gc 27840 tcctcaggcg ccgccggcac tgcccgttcg ccgacccaac cgtagatggg acaccactgg 27900 aaccagggcc ggtaagtcca agcagccgcc gccgttagcc caagagcaac aacagcgcca 27960 aggctaccgc tcatggcgcg ggcacaagaa cgc catagtt gcttgcttgc aagactgtgg 28020 gggcaacatc tccttcgccc gccgctttct tctctaccat cacggcgtgg ccttcccccg 28080 taacatcctg cattactacc gtcatctcta cagcccatac tgcaccggcg gcagcggcag 28140 caacagcagc ggccacacag aagcaaaggc gaccggatag caagactctg acaaagccca 28200 agaaatccac agcggcggca gcagcaggag gaggagcgct gcgtctggcg cccaacgaac 28260 ccgtatcgac ccgcgagctt agaaacagga tttttcccac tctgtatgct atatttcaac 28320 agagcagggg ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga tccctcaccc 28380 gcagctgcct gtatcacaaa agcgaagatc agcttcggcg cac gctggaa gacgcggagg 28440 ctctcttcag taaatactgc gcgctgactc ttaaggacta gtttcgcgcc ctttctcaaa 28500 tttaagcgcg aaaactacgt catctccagc ggccacaccc ggcgccagca cctgttgtca 28560 gcgccattat gagcaaggaa attcccacgc cctacatgg gagttaccag ccacaaatgg 28620 gacttgcggc tggagctgcc caagactact caacccgaat aaactacatg agcgcgggac 28680 cccacacatgat atcccgg aagt tcagat gactaactca ggggcgcagc ttgcgggcgg ctttcgtcac agggtgcggt 28920 cgcccgggca gggtataact cacctgacaa tcagagggcg aggtattcag ctcaacgacg 28980 agtcggtgag ctcctcgctt ggtctccgtc cggacgggac atttcagatc ggcggcgccg 29040 gccgctcttc attcacgcct cgtcaggcaa tcctaactct gcagacctcg tcctctgagc 29100 cgcgctctgg aggcattgga actctgcaat ttattgagga gtttgtgcca tcggtctact 29160 ttaacccctt ctcgggacct cccggccact atccggatca atttattcct aactttgacg 29220 cggtaaagga ctcggcggac ggctacgact gaatgttaag tggagaggca gagcaactgc 2928 0 gcctgaaaca cctggtccac tgtcgccgcc acaagtgctt tgcccgcgac tccggtgagt 29340 tttgctactt tgaattgccc gaggatcata tcgagggccc ggcgcacggc gtccggctta 29400 ccgcccaggg agagcttgcc cgtagcctga ttcgggagtt tacccagcgc cccctgctag 29460 ttgagcggga caggggaccc tgtgttctca ctgtgatttg caactgtcct aaccctggat 29520 tacatcaaga tcctctagtt aatgtcagg t cgcctaagtc gattaactag agtacccggg 29580 gatcttattc cctttaacta ataaaaaaaa ataataaagc atcacttact taaaatcagt 29640 tagcaaattt ctgtccagtt tattcagcag cacctccttg ccctcctccc agctctggta 29700 ttgcagcttc ctcctggctg caaactttct ccacaatcta aatggaatgt cagtttcctc 29760 ctgttcctgt ccatccgcac ccactatctt catgttgttg cagatgaagc gcgcaagacc 29820 gtctgaagat accttcaacc ccgtgtatcc atatgacacg gaaaccggtc ctccaactgt 29880 gccttttctt actcctccct ttgtatcccc caatgggttt caagagagtc cccctggggt 29940 actctctttg cgcctatccg aacctctagt tacctccaat gg catgcttg cgctcaaaat 30000 gggcaacggc ctctctctgg acgaggccgg caaccttacc tcccaaaatg taaccactgt 30060 gagcccacct ctcaaaaaaa ccaagtcaaa cataaacctg gaaatatctg cacccctcac 30120 agttacctca gaagccctaa ctgt ggctgc cgccgcacct ctaatggtcg cgggcaacac 30180 actcaccatg caatcacagg ccccgctaac cgtgcacgac tccaaactta gcattgccac 30240 ccaaggaccc ctcacagtgt cagaaggaaa gctagccctg caaacag gccccctcac 30300 caccaccgat agcagtaccc ttactatcac tgcctcaccc cctctaacta ctgccactgg 30360 tagcttgggc attgacttga aagagcccat ttatacacaa aatggaaaac taggactaa a 30420 gtacggggct cctttgcatg taacagacga cctaaacact ttgaccgtag caactggtcc 30480 aggtgtgact attaataata cttccttgca aactaaagtt actggagcct tgggttttga 30540 ttcacaaggc aatatgcaac ttaatgtagc aggaggacta aggatt gatt ctcaaaacag 30600 acgccttata cttgatgtta gttatccgtt tgatgctcaa aaccaactaa atctaagact 30660 aggacagggc cctcttttta taaactcagc ccacaacttg gatattaact acaacaaagg 30720 cctttacttg tttacagctt caaacaattc caaaaagctt gaggttaacc taagcactgc 30780 caaggggttg atgtttgacg ctacagccat agccattaat gcaggagatg ggcttgaatt 3084 0 tggttcacct aatgcaccaa acacaaatcc cctcaaaaca aaaattggcc atggcctaga 30900 atttgattca aacaaggcta tggttcctaa actaggaact ggccttagtt ttgacagcac 30960 aggtgccatt acagtaggaa acaaaaataa tgataagcta actttgtgga ccgga ataaa 31020 ccctccacct aactgtcaaa ttgtggaaaa cactaataca aatgatggca aacttacttt 31080 agttatagta aaaaatggag ggcttgttaa tggctacgtg tctctagttg gtgtatcaga 31140 cactgtgaac caaatgttca cacaaaagac agcaaacatc caattaagat tatattttga 31200 ctcttctgga aatctattaa ctgaggaatc agacttaaaa attccactta aaaataaatc 31260 ttctacagcg accagtgaaa ctgtagccag cagcaaagcc tttatgccaa gtactacagc 31320 ttatcccttc aacaccacta ctagggatag tgaaaactac attcatggaa tatgttacta 31380 catgactagt tatgatagaa gtctatttcc cttgaacatt tctataatgc taaacagcc g 31440 tatgatttct tccaatgttg cctatgccat acaatttgaa tggaatctaa atgcaagtga 31500 atctccagaa agcaacatag ctacgctgac cacatccccc tttttctttt cttacattac 31560 agaagacgac aactaaagaa tcgtttgtgt tatgtttcaa cgtgtttatt tttcaattgc 31620 agaaaatttc aagtcatttt tcattcagta gtatagcccc accaccacat agcttataca 31680 gatcaccgta ccttaatcaa actcacagaa ccctagtatt caacctgcca cctccctccc 31740 aacacacaga gtacacagtc ctttctcccc ggctggcctt aaaaagcatc atatcatggg 31800 taacagacat attcttaggt gtttatattcc acacggtttc ctgtcgagcc aaacgctcat 31860 cagtgat att aataaactcc ccgggcagct cacttaagtt catgtcgctg tccagctgct 31920 gagccacagg ctgctgtcca acttgcggtt gcttaacggg cggcgaagga gaagtccacg 31980 cctacatggg ggtagagtca taatcgtgca tcaggatagg gcggtggtgc tgcagcagcg 32040 cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga atacaacatg gcagtggtct 32100 cctcagcgat gatt cgcacc gcccgcagca taaggcgcct tgtcctccgg gcacagcagc 32160 gcaccctgat ctcacttaaa tcagcacagt aactgcagca cagcaccaca atattgttca 32220 aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc ggggaccaca gaacccacgt 3228 0 ggccatcata ccacaagcgc aggtagatta agtggcgacc cctcataaac acgctggaca 32340 taaacattac ctcttttggc atgttgtaat tcaccacctc ccggtaccat ataaacctct 32400 gattaaacat ggcgccatcc accaccatcc taaaccagct ggccaaaacc tgcccgccgg 32460 ctatacactg cagggaaccg ggactggaac aatgacagtg gagagcccag gactcgtaac 32520 catggatcat catgctcgtc atgatatcaa tgttggca ca acacaggcac acgtgcatac 32580 acttcctcag gattacaagc tcctcccgcg ttagaaccat atcccaggga acaacccatt 32640 cctgaatcag cgtaaatccc acactgcagg gaagacctcg cacgtaactc acgttgtgca 32700 ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc cagtatggta gcgcgggttt 32760 ctgtctcaaa aggaggtaga cgatccctac tgtacggagt gcgccgagac aaccgagatc 32820 gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt agtcatattt cctgaagcaa 32880 aaccaggtgc ggggcgtgaca aacagatctg cgtctccggt ctcgccgctt agatcgctct 32940 gtgtagtagt tgtagtatat ccactctctc aaagcatcca gg cgccccct ggcttcgggt 33000 tctatgtaaa ctccttcatg cgccgctgcc ctgataacat ccaccaccgc agaataagcc 33060 acacccagcc aacctacaca ttcgttctgc gagtcacaca cgggaggagc gggaagagct 33120 ggaagaacca tgtttttttt tttatccaa aagattatcc aaaacctcaa aatgaagatc 33180 tattaagtga acgcgctccc ctccggtggc gtggtcaaac tctacagcca aagaacagat 33240 aatggcattt gtaagatgtt gcacaatggc ttccaaaagg caaacggccc tcacgtccaa 33300 gtggacgtaa aggctaaacc cttcagggtg aatctcctct ataaacattc cagcaccttc 33360 aaccatgccc aaataattct catctcgcca ccttctcaat atatctcta a gcaaatcccg 33420 aatattaagt ccggccattg taaaaatctg ctccagagcg ccctccacct tcagcctcaa 33480 gcagcgaatc atgattgcaa aaattcaggt tcctcacaga cctgtataag attcaaaagc 33540 ggaacattaa caaaaatacc gcgatcccgt a ggtcccttc gcagggccag ctgaacataa 33600 tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc caggaaccat gacaaaagaa 33660 cccacactga ttatgacacg catactcgga gctatgctaa ccagcgtagc cccgatgtaa 33720 gcttgttgca tgggcggcga tataaaatgc aaggtgctgc tcaaaaaatc aggcaaagcc 33780 tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca gataaa ggca ggtaagctcc 33840 ggaaccacca cagaaaaaga caccattttt ctctcaaaca tgtctgcggg tttctgcata 33900 aacacaaat aaaataacaa aaaaacattt aaacattaga agcctgtctt acaacaggaa 33960 aaacaaccct tataagcata agacggacta cggccat gcc ggcgtgaccg taaaaaaact 34020 ggtcaccgtg attaaaaagc accaccgaca gctcctcggt catgtccgga gtcataatgt 34080 aagactcggt aaacacatca ggttgattca catcggtcag tgctaaaaag cgaccgaaat 34140 agcccggggg aatacatacc cgcaggcgta gagacaacat tacagccccc ataggaggta 34200 taacaaaatt aataggagag aaaaacacat aaacacctga aaaaccctcc tgcctaggca 34260 aaatagcacc ctcccgctcc agaacaacat acagcgcttc cacagcggca gccataacag 34320 tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca ccactcgaca cggcaccagc 34380 tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg agtatata ggactaaa aa 34440 atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa ccgcacgcga acctacgccc 34500 agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt cacttccgtt ttcccacgtt 34560 acgtcacttc ccattttaag aaaactacaa ttcccaacac atacaagtta ctccgcccta 34620 aaacctacgt cacccgcccc gttcccacgc cccgcgccac gtcacaaact ccaccccctc 34680attatcatat tggctt caat ccaaaataag gtatattatt gatgatg 34727 <210> 26 <211> 37675 <212> DNA <213> artificial sequence <220> <223> plasmid #3 vector <400> 26 ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60 aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120 ggctgcggcg agcggtatca gctcactcaa aggcggta at acggttatcc acagaatcag 180 gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240 aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300 gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360 ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420 cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480 cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540 gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600 cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660 agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720 ctctgctgaa gccagttacc ttcgga aaaa gagttggtag ctcttgatcc ggcaaacaaa 780 ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840 gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900 cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960 attaaaaatg aagttttaaa tcaatctaaa gtatata tga gtaaacttgg tctgacagtt 1020 accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080 ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140 gtgctgcaat gataccgcga gacccac gct caccggctcc agatttatca gcaataaacc 1200 agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260 ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320 ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380 cgtagaaagc cagtccgcag aaacggtgct gaccccgg at gaatgtcagc tactgggcta 1440 tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500 ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560 cgccctctgg taaggttggg aagccctg ca aagtaaactg gatggctttc ttgccgccaa 1620 ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680 tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740 gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800 cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860 aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920 tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980 atctcctgtc atctcacctt gctcctgccg aga aagtatc catcatggct gatgcaatgc 2040 ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100 tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160 agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220 gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280 gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340 tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400 tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgcctt ctat cgccttcttg 2460 acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520 gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580 gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640 aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700 gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760 tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820 gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgc gctt 2880 aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940 atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000 tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060 atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120 tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180 aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240 gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 33 00 cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360 gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420 ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480 ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540 atgacggtaa atggcccgcc tggcattatg ccc agtacat gaccttatgg gactttccta 3600 cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660 acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg 3720 acgtcaatgg gagtttgttt tggca ccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780 actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc t gtgttcctg gtgctgctgc 4020 cactggtgtc cagccagtgt gtgaacctga ccaccaggac ccaacttcct cctgcctaca 4080 ccaactcctt caccagggga gtctactacc ctgacaaggt gttcaggtcc tctgtgctgc 4140 acagcaccca ggacctgttc ctgccattct tcagcaatgt gacctggttc catgccatcc 4200 atgtgtctgg caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg 4260 gagtctactt tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca 4320 ccctggacag caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta 4380 aggtgtgtga gttccagttc tgtaatgacc cattcctggg agtctactac cacaagaaca 4440 acaagtcctg gatggagtct gagttcaggg tctactcctc tgccaacaac tgtacctttg 4500 aatatgtgag ccaaccattc ctgatggact tggagggcaa gcagggcaac ttcaagaacc 4560 tgagggagtt tgtgttcaag aacattgatg gctactt caa gatttacagc aaacacacac 4620 caatcaacct ggtgagggac ctgccacagg gcttctctgc cttggaacca ctggtggacc 4680 tgccaattgg catcaacatc accaggttcc agaccctgct ggctctgcac aggtcctacc 4740 tgacacctgg agactcctcc tctggctgga cagcaggagc agcagcctac tatgtgggct 4800 acctccaacc aaggaccttc ctgctgaaat acaatgagaa tggcaccatc acagatg ctg 4860 tggactgtgc cctggaccca ctgtctgaga ccaagtgtac cctgaaatcc ttcacagtgg 4920 agaagggcat ctaccagacc agcaacttca gggtccaacc aacagagagc attgtgaggt 4980 ttccaaacat caccaacctg tgtccatttg gagaggtgtt caatgcca cc aggtttgcct 5040 ctgtctatgc ctggaacagg aagaggatta gcaactgtgt ggctgactac tctgtgctct 5100 acaactctgc ctccttcagc accttcaagt gttatggagt gagcccaacc aaactgaatg 5160 acctgtgttt caccaatgtc tatgctgact cctttgtgat taggggat gaggtgagac 5220 agattgcccc tggacaaaca ggcaagattg ctgactacaa ctacaaactg cctgatgact 5280 t cacaggctg tgtgattgcc tggaacagca acaacctgga cagcaaggtg ggaggcaact 5340 acaactacct ctacagactg ttcaggaaga gcaacctgaa accatttgag agggacatca 5400 gcacagagat ttaccaggct ggcagcacac catgtaatgg agtggagggc ttcaactgtt 5460 act ttccact ccaatcctat ggcttccaac caaccaatgg agtgggctac caaccataca 5520 gggtggtggt gctgtccttt gaactgctcc atgcccctgc cacagtgtgt ggaccaaaga 5580 agagcaccaa cctggtgaag aacaagtgg tgaacttcaa cttcaatgga ctgacaggca 5640 caggagtgct gacagagagc aacaagaagt tcctgccatt ccaacagttt ggcagggaca 5700 ttgctgac ac cacagatgct gtgagggacc cacagacctt ggagattctg gacatcacac 5760 catgttcctt tggaggagtg tctgtgatta cacctggcac caacaccagc aaccaggtgg 5820 ctgtgctcta ccaggatgtg aactgtactg aggtgcctgt ggctatccat gctgaccaac 5880 ttaca ccaac ctggagggtc tacagcacag gcagcaatgt gttccagacc agggctggct 5940 gtctgattgg agcagagcat gtgaacaact cctatgagtg tgacatccca attggagcag 6000 gcatctgtgc ctcctaccag acccagaccg gtggcggtgg gtcgaggtct gtggcaagcc 6060 agagcatcat tgcctacaca atgagtctgg gagcagagaa ctctgtggct tacagcaaca 6120 acagcattgc catcccaacc aacttcacca tctctgtgac cacagagatt ctgcctgtga 6180 gtatgaccaa gacctctgg gactgtacaa tgtatatctg tggagacagc acagagtgta 6240 gcaacctgct gctccaatat ggctccttct gtacccaact taacagggct ctgacaggca 6300 ttgctgtgga acaggacaag aacacccagg aggtgtttgc ccaggtgaag cagatttaca 6360 agacacctcc aatcaaggac tttggaggct tcaacttcag ccagattctg cctgacccaa 6420 gcaagccaag caagaggtcc ttcattgagg acctgctgtt caacaaggtg accctggctg 6480 atgctggctt catcaagcaa tatggagact gtctgggaga cattgctgcc agggacctga 6540 tttgtgccca gaagttcaat ggactgacag tgct gcctcc actgctgaca gatgagatga 6600 ttgcccaata cacctctgcc ctgctggctg gcaccatcac ctctggctgg acctttggag 6660 caggagcagc cctccaaatc ccatttgcta tgcagatggc ttacaggttc aatggcattg 6720 gagtgaccca gaatgtgctc tatgagaacc agaaactgat tgccaaccag ttcaactctg 6780 ccattggcaa gattcaggac tccctgtcca gcacagcctc tgccctgggc aaactccaag 6840 atgtggtgaa ccagaatgcc caggctctga acaccctggt gaagcaactt tccagcaact 6900 ttggagccat ctcctctgg ctgaatgaca tcctgagcag actggacaag gtggaggctg 6960 aggtccagat tgacagactg attacaggca gactccaatc cct ccaaacc tatgtgaccc 7020 aacaacttat cagggctgct gagattaggg catctgccaa cctggctgcc accaagatga 7080 gtgagtgtgt gctgggacaa agcaagaggg tggacttctg tggcaagggc taccacctga 7140 tgagttttcc acagtctgcc cctcatggag tggtgttcct gcatgtgacc tatgtgcctg 7200 cccaggagaa gaacttcacc acagcccctg ccatctgcca tgatggcaag gctcactttc 7260 caagggaggg agtgtttgtg agcaatggca cccactggtt tgtgacccag aggaacttct 7320 atgaaccaca gattatcacc acagacaaca cctttgtgtc tggcaactgt gatgtggtga 7380 ttggcattgt gaacaacaca gtctatgacc cactccaacc tgaactggac tccttca agg 7440 aggaactgga caaatacttc aagaaccaca ccagccctga tgtggacctg ggagacatct 7500 ctggcatcaa tgcctctgtg gtgaacatcc agaaggagat tgacagactg aatgaggtgg 7560 ctaagaacct gaatgagtcc ctgattgacc tccaagaact gggcaaatat ga acaataca 7620 tcaagtggcc atgaaaattg atcataatca gccataccac atttgtagag gttttacttg 7680 ctttaaaaaa cctccccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 7740 ttgttaactt gttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 7800 tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ct catcaatg 7860 tatcttaacg cggatctggg cgtggttaag ggtgggaaag aatatataag gtgggggtct 7920 tatgtagttt tgtatctgtt ttgcagcagc cgccgccgcc atgagcacca actcgtttga 7980 tggaagcatt gtgagctcat atttgacaac gcgcatgccc c catgggccg gggtgcgtca 8040 gaatgtgatg ggctccagca ttgatggtcg ccccgtcctg cccgcaaact ctactacctt 8100 gacctacgag accgtgtctg gaacgccgtt ggagactgca gcctccgccg ccgcttcagc 8160 cgctgcagcc accgcccgcg ggattgtgac tgactttgct ttcctgagcc cgcttgcaag 8220 cagtgcagct tcccgttcat ccgcccgcga tgacaagttg acggctcttt tggcacaatt 8280 ggattctttg acccgggaac ttaatgtcgt ttctcagcag ctgttggatc tgcgccagca 8340 ggtttctgcc ctgaaggctt cctcccctcc caatgcggtt taaaacataa ataaaaaacc 8400 agactctgtt tggatttgga tcaagca agt gtcttgctgt cttatttag gggttttgcg 8460 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 8520 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 8580 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 8640 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 8 700 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 8760 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 8820 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 8880 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 8940 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 9000 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 9060 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 9120 gtagttaccc tcacag attt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 9180 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 9240 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 9300 cgg ctgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 9360 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 9420 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 9480 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 9540 cacctgctct acggcat ctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 9600 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 9660 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgc g 9720 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 9780 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 9840 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagg cagacttttg 9900 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 9960 gccccgcaga cggtctcgca ttccacga gc caggtgagct ctggccgttc ggggtcaaaa 10020 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 10080 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 1014 0 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 10200 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 10260 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 10320 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 10380 gtgggggcgc gttcgtcctc actctcttcc gcatcgct gt ctgcgagggc cagctgttgg 10440 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 10500 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 10560 atctggtcag aaaagaca at ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 10620 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 10680 a ggcgctcgt tggtccagca gaggcggccg 10860 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 10920 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 10980 aag tctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 11040 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 11100 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 11160 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 11220 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 11280 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 11340 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 11400 gcgcagtagt ccagggtttc cttgatga tg tcatacttat cctgtccctt ttttttccac 11460 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 11520 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 11580 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 11640 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 1 1700 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 11760 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 11820 cggaagggtc ccggcacctc ggaacggttg ttaattac ct gggcggcgag cacgatctcg 11880 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 11940 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 12000 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 12060 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 12120 ttttctgg gg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 12180 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 12240 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctc tacatcg 12300 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 12360 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 12420 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 12480 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 12540 ccctcgcctg gcgggt ttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 12600 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 12660 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtc catg 12720 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 12780 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 12840 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 12900 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 12960 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 13020 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 13080 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtga gc ttgaacctga 13140 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 13200 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 13260 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 13320 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 13380 ccccttcggc atcgcgggcg cgcatg acca cctgcgcgag attgagctcc acgtgccggg 13440 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 13500 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 13560 cctca aggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 13620 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 13680 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 13740 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 13800 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc g cggcgacgg cgcatggtct 13860 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 13920 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 13980 acaattgttg tgtag gtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 14040 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 14100 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 14160 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 14220 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc t tcgttttga catcggcgca 14280 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 14340 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 14400 ctcttcctcc catgcgtgg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 14460 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 14520 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 14580 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 14640 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatccaccca cgcggac gcg gttccagatg ttgcgcagcg 14880 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 14940 tctagcgtgc aaaaggag cctgtaagcg ggcactcttc cgtggtctgg tggataaatt 15000 cgcaagggta tcatggcgga cgaccggggt tcgagccccg tatccggccg tccgccgtga 15060 tccatgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca acgggggagt 15120 gctcctt ttg gcttccttcc aggcgcggcg gctgctgcgc tagctttttt ggccactggc 15180 cgcgcgcagc gtaagcggtt aggctggaaa gcgaaagcat taagtggctc gctccctgta 15240 gccggagggt tattttccaa gggttgagtc gcgggacccc cggtt cgagt ctcggaccgg 15300 ccggactgcg gcgaacgggg gtttgcctcc ccgtcatgca agaccccgct tgcaaattcc 15360 tccggaaaca gggacgagcc ccttttttgc ttttcccaga tgcatccggt gctgcggcag 15420 atgcgccccc ctcctcagca gcggcaagag caagagcagc ggcagacatg cagggcaccc 15480 tcccctcctc ctaccgcgtc aggaggggcg acatccgcgg ttgacgcggc agcagatggt 15540 gattacgaac cc ccgcggcg ccgggcccgg cactacctgg acttggagga gggcgagggc 15600 ctggcgcggc taggagcgcc ctctcctgag cggcacccaa gggtgcagct gaagcgtgat 15660 acgcgtgagg cgtacgtgcc gcggcagaac ctgtttcgcg accgcgaggg agaggagccc 15720 gaggagatgc gggatcgaaa gttccacgca gggcgcgagc tgcggcatgg cctgaatcgc 15780 gagcggttgc tgcgcgagga ggactttgag cccgacgcgc gaaccgggat tagtcccgcg 15840 cgcgcacacg tggcggccgc cgacctggta accgcatacg agcagacggt gaaccaggag 15900 attaactttc aaaaaagctt taacaaccac gtgcgtacgc ttgtggcgcg cgaggaggtg 15960 gctataggac tgatgcatct gtg ggacttt gtaagcgcgc tggagcaaaa cccaaatagc 16020 aagccgctca tggcgcagct gttccttata gtgcagcaca gcagggacaa cgaggcattc 16080 agggatgcgc tgctaaacat agtagagccc gagggccgct ggctgctcga tttgataaac 1 6140 atcctgcaga gcatagtggt gcaggagcgc agcttgagcc tggctgacaa ggtggccgcc 16200 atcaactatt ccatgcttag cctgggcaag ttttacgccc gcaagatata ccatacccct cg cgagctga tgcacagcct gcaaagggcc 16440 ctggctggca cgggcagcgg cgatagagag gccgagtcct actttgacgc gggcgctgac 16500 ctgcgctggg ccccaagccg acgcgccctg gaggcagctg gggccggacc tgggctggcg 16560 gtggcaccc g cgcgcgctgg caacgtcggc ggcgtggagg aatatgacga ggacgatgag 16620 tacgagccag aggacggcga gtactaagcg gtgatgtttc tgatcagatg atgcaagacg 16680 caacggaccc ggcggtgcgg gcggcgctgc agagccagcc gtccggcctt aactccacgg 16740 acgactggcg ccaggtcatg gaccgcatca tgtcgctgac tgcgcgcaat cctgacgcgt 16800 tccggcagca gccgcaggcc aaccggctct ccgcaattct ggaag cggtg gtcccggcgc 16860 gcgcaaaccc cacgcacgag aaggtgctgg cgatcgtaaa cgcgctggcc gaaaacaggg 16920 ccatccggcc cgacgaggcc ggcctggtct acgacgcgct gcttcagcgc gtggctcgtt 16980 acaacagcgg caacgtg cag accaacctgg accggctggt gggggatgtg cgcgaggccg 17040 tggcgcagcg tgagcgcgcg cagcagcagg gcaacctggg ctccatggtt gcactaaacg 17100 ccttcctgag tacacagccc gccaacgtgc cgcggggaca ggaggactac accaactttg 17160 tgagcgcact gcggctaatg gtgactgaga caccgcaaag tgaggtgtac cagtctgggc 17220 cagactattt tttccagacc agtagacaag gcctgcagac cgtaaacctg agccaggctt 17280 tcaaaaactt gcaggggctg tggggggtgc gggctcccac aggcgaccgc gcgaccgtgt 17340 ctagcttgct gacgcccaac tcgcgcctgt tgctgctgct aatagcgccc ttcacggaca 17400 gtggcagcgt gtcccgggac acatacctag gtc acttgct gacactgtac cgcgaggcca 17460 taggtcaggc gcatgtggac gagcatactt tccaggagat tacaagtgtc agccgcgcgc 17520 tggggcagga ggacacgggc agcctggagg caaccctaaa ctacctgctg accaaccggc 17580 ggcagaagat cccctcgttg cacagtttaa acagcgagga ggagcgcatt ttgcgctacg 17640 tgcagcagag cgtgagcctt aacctgatgc gcgacggggt aacgcccagc gtggcgctgg 17700 acatgaccgc gcgcaacatg gaaccgggca tgtatgcctc aaaccggccg tttatcaacc 17760 gcctaatgga ctacttgcat cgcgcggccg ccgtgaaccc cgagtatttc accaatgcca 17820 tcttgaaccc gcactggcta ccgccccctg gtttct acac cgggggattc gaggtgcccg 17880 agggtaacga tggattcctc tgggacgaca tagacgacag cgtgttttcc ccgcaaccgc 17940 agaccctgct agagttgcaa cagcgcgagc aggcagaggc ggcgctgcga aaggaaagct 18000 tccgcaggcc aagcagcttg tccgatctag gcgctgcggc cccgcggtca gatgctagta 18060 gcccatttcc aagcttgata gggtctctta ccagcactcg caccacccgc ccgcgcctgc 18120 tgggcgagga ggagtaccta aacaactcgc tgctgcagcc gcagcgcgaa aaaaacctgc 18180 ctccggcatt tcccaacaac gggatagaga gcctagtgga caagatgagt agatggaaga 18240 cgtacgcgca ggagcacagg gacgtgccag gcccgcgccc gcccacccgt cgtcaaaggc 18300 acgaccgtca gcggggtctg gtgtgggagg acgatgactc ggcagacgac agcagcgtcc 18360 tggatttggg agggagtggc aacccgtttg cgcaccttcg ccccaggctg gggagaatgt 18420 tttaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 18480 ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 18540 tccctcctac g agagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 18600 cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 18660 aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctgg t 18720 ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 18780 gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 18840 tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 18900 aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 18960 gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 19020 gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 19080 cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 19140 ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 19200 aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 19260 cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 19320 gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 19380 ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg gcagcaacag 19440 cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 19500 ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 19560 cgctgaggcc gaagca gcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 19620 gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 19680 cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 19740 cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 19800 cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 19860 ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 19920 caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 19980 gacccacgtg ttcaatcgct ttcccg agaa ccagattttg gcgcgcccgc cagcccccac 20040 catcacccac gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 20100 caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 20160 ctacgttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 20220 agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 20280 aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 20340 gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 20400 tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 20460 gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 20520 gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 20580 acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 20640 ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 2 at gtatccag cggcggcggc 20880 gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 20940 ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 21000 ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 21060 cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 21120 acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 21180 gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 21240 gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggac g agggcaaccc 21300 aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 21360 agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 21420 acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 21480 gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 21540 ggacgttcag atac ccacta ccagtagcac cagtattgcc accgccacag agggcatgga 21600 gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 21660 ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 21720 cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 21780 tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct accgccccag 21840 aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 21900 ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 21960 ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 22020 tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 22080 gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 22140 ccggcggc gg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 22200 actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 22260 gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 22320 acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 22380 ccccgcgaca cggctcgcgc ccgttcatgg gaaact ggca agatatcggc accagcaata 22440 tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 22500 ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 22560 agttgaaaga gca aaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 22620 gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 22680 gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 22740 aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 22800 cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgc g cccatggcta 22860 ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 22920 agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 22980 ccctgcgccg cgccgccagc ggt ccgcgat cgttgcggcc cgtagccagt ggcaactggc 23040 aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 23100 tctgatagct aacgtgtcgt atgtgtgtca tgtatgcgtc catgtcgccg ccagaggagc 23160 tgctgagccg ccgcgcgccc gctttccaag atggctaccc cttcgatgat gccgcagtgg 23220 tcttacatgc acatctcggg ccaggacgcc tcggagtacc tgagccccgg gctgg tgcag 23280 tttgcccgcg ccaccgagac gtacttcagc ctgaataaca agtttagaaa ccccacggtg 23340 gcgcctacgc acgacgtgac cacagaccgg tcccagcgtt tgacgctgcg gttcatccct 23400 gtggaccgtg aggatactgc gtactcgt ac aaggcgcggt tcaccctagc tgtgggtgat 23460 aaccgtgtgc tggacatggc ttccacgtac tttgacatcc gcggcgtgct ggacaggggc 23520 cctactttta agccctactc tggcactgcc tacaacgccc tggctcccaa gggtgcccca 23580 aatccttgcg aatgggatga agctgctact gctcttgaaa taaacctaga agaagaggac 23640 gatgacaacg aagacgaagt agacgagcaa gctgagcagc aaaaaactca cgtatttggg 23700 caggcgcctt attctggtat aaatattaca aaggagggta ttcaaatagg tgtcgaaggt 23760 caaacaccta aatatgccga taaaacattt caacctgaac ctcaaatagg agaatctcag 23820 tggtacgaaa cagaaattaa tcatgcagct gggagagtcc taaaaaagac tacccca atg 23880 aaaccatgtt acggttcata tgcaaaaccc acaaatgaaa atggagggca aggcattctt 23940 gtaaagcaac aaaatggaaa gctagaaagt caagtggaaa tgcaattttt ctcaactact 24000 gaggcagccg caggcaatgg tgataacttg actcctaaag tggtattgta cagtgaagat 24060 gtagatatag aaaccccaga cactcatatt tcttacatgc ccactattaa ggaaggtaac 24120 tcacgagaac taatggg a acaatctatg cccaacaggc ctaattacat tgcttttagg 24180 gacaatttta ttggtctaat gtattacaac agcacgggta atatgggtgt tctggcgggc 24240 caagcatcgc agttgaatgc tgttgtagat ttgcaagaca gaaacacaga gctttcatac 24300 cagct tttgc ttgattccat tggtgataga accaggtact tttctatgtg gaatcaggct 24360 gttgacagct atgatccaga tgttagaatt attgaaaatc atggaactga agatgaactt 24420 ccaaattact gctttccact gggaggtgtg attaatacag agactcttac caaggtaaaa 24480 cctaaaacag gtcaggaaaa tggatgggaa aaagatgcta cagaattttc agataaaaat 24540 gaaataagag ttggaaataa ttttgccatg gaaatcaatc taaatgccaa cctgtggaga 24600 aatttcctgt actccaacat agcgctgtat ttgcccgaca agctaaagta cagtccttcc 24660 aacgtaaaaa tttctgataa cccaaacacc tacgactaca tgaacaagcg agtggtggct 24 720 cccgggctag tggactgcta cattaacctt ggagcacgct ggtcccttga ctatatggac 24780 aacgtcaacc catttaacca ccaccgcaat gctggcctgc gctaccgctc aatgttgctg 24840 ggcaatggtc gctatgtgcc cttccacatc caggtgcctc agaagttctt tgccattaaa 24900 aacctccttc tcctgccggg ctcatacacc tacgagtgga acttcaggaa ggatgttaac 24960 atggttctgc agagctccct agga aatgac ctaagggttg acggagccag cattaagttt 25020 gatagcattt gcctttacgc caccttcttc cccatggccc acaacaccgc ctccacgctt 25080 gaggccatgc ttagaaacga caccaacgac cagtccttta acgactatct ctccgccgcc 25140 aacatgctct acc ctatacc cgccaacgct accaacgtgc ccatatccat cccctcccgc 25200 aactgggcgg ctttccgcgg ctgggccttc acgcgcctta agactaagga aaccccatca aaatta agcg ctcagttgac 25440 ggggagggtt acaacgttgc ccagtgtaac atgaccaaag actggttcct ggtacaaatg 25500 ctagctaact ataacattgg ctaccagggc ttctatatcc cagagagcta caaggaccgc 25560 atgtactcct tctttagaaa cttccagccc atga gccgtc aggtggtgga tgatactaaa 25620 tacaaggact accaacaggt gggcatccta caccaacaca acaactctgg atttgttggc 25680 taccttgccc ccaccatgcg cgaaggacag gcctaccctg ctaacttccc ctatccgctt 25740 ataggcaaga ccgcagttga cagcattacc cagaaaaagt ttctttgcga tcgcaccctt 25800 tggcgcatcc cattctccag taactttatg tccatgggcg cactcacaga cctgggccaa 25860 aaccttctct acgccaactc cgcccacgcg ctagacatga cttttgaggt ggatcccatg 25920 gacgagccca cccttcttta tgttttgttt gaagtctttg acgtggtccg tgtgcaccag 25980 ccgcaccgcg gcgtcatcga aacc gtgtac ctgcgcacgc ccttctcggc cggcaacgcc 26040 acaacataaa gaagcaagca acatcaacaa cagctgccgc catgggctcc agtgagcagg 26100 aactgaaagc cattgtcaaa gatcttggtt gtgggccata tttttgggc acctatgaca 26160 agcgctttcc aggctttgtt tctccacaca agctcgcctg cgccatagtc aatacggccg 26220 gtcgcgagac tgggggcgta cactggatgg cctttgcctg gaacccgc ac tcaaaaacat 26280 gctacctctt tgagcccttt ggcttttctg accagcgact caagcaggtt taccagtttg 26340 agtacgagtc actcctgcgc cgtagcgcca ttgcttcttc ccccgaccgc tgtataacgc 26400 tggaaaagtc cacc caaagc gtacaggggc ccaactcggc cgcctgtgga ctattctgct 26460 gcatgtttct ccacgccttt gccaactggc cccaaactcc catggatcac aaccccacca 26520 tgaaccttat taccggggta cccaactcca tgctcaacag tccccaggta cagccccaccc 26580 tgcgtcgcaa ccaggaacag ctctacagct tcctggagcg ccactcgccc tacttccgca 26640 gccacagtgc gcagattagg agcgccactt cttttgtca cttgaaaaac atgtaaaaat 26700 aatgtactag agacactttc aataaaggca aatgctttta tttgtacact ctcgggtgat 26760 tatttacccc cacccttgcc gtctgcgccg tttaaaaatc aaaggggttc tgccgcgcat 26820 cgctatgcgc cactggcagg gacacgttgc gatactgg tg tttagtgctc cacttaaact 26880 caggcacaac catccgcggc agctcggtga agttttcact ccacaggctg cgcaccatca 26940 ccaacgcgtt tagcaggtcg ggcgccgata tcttgaagtc gcagttgggg cctccgccct 27000 gcgcgcgcga gttgcgatac acagggttgc agcactggaa cactatcagc gccgggtggt 27060 gcacgctggc cagcacgctc ttgtcggaga tcagatccgc gtccaggtcc tccgcgttgc 27 27240 gatacagcgc ctgcataaaa gccttgatct gcttaaaagc cacctgagcc tttgcgcctt 27300 cagagaagaa catgccgcaa gacttgccgg aaaactgatt ggccggacag gccgcgtcgt 27360 gcacgcagca ccttgcgtcg gtgttggaga tctgcaccac att tcggccc caccggttct 27420 tcacgatctt ggccttgcta gactgctcct tcagcgcgcg ctgcccgttt tcgctcgtca 27480 catccatttc aatcacgtgc tccttattta tcataatgct tccgtgtaga cacttaagct 27540 cgccttcgat ct cagcgcag cggtgcagcc acaacgcgca gcccgtgggc tcgtgatgct 27600 tgtaggtcac ctctgcaaac gactgcaggt acgcctgcag gaatcgcccc atcatcgtca 27660 caaaggtctt gttgctggtg aaggtcagct gcaacccgcg gtgctcctcg ttcagccagg 27720 tcttgcatac ggccgccaga gcttccactt ggtcaggcag tagtttgaag ttcgccttta 27780 gatcgttatc cacgtggtac ttgtccatca gcgcgcgcgc agcc tccatg cccttctccc 27840 acgcagacac gatcggcaca ctcagcgggt tcatcaccgt aatttcactt tccgcttcgc 27900 tgggctcttc ctcttcctct tgcgtccgca taccacgcgc cactgggtcg tcttcattca 27960 gccgccgcac tggg cgctta cctcctttgc catgcttgat tagcaccggt gggttgctga 28020 aacccaccat ttgtagcgcc acatcttctc tttcttcctc gctgtccacg attacctctg 28080 gtgatggcgg gcgctcgggc ttgggagaag ggcgcttctt tttcttcttg ggcgcaatgg 28140 ccaaatccgc cgccgaggtc gatggccgcg ggct gggtgt gcgcggcacc agcgcgtctt 28200 gtgatgagtc ttcctcgtcc tcggactcga tacgccgcct catccgcttt t ttgggggcg 28260 cccggggagg cggcggcgac ggggacgggg acgacacgtc ctccatggtt gggggacgtc 28320 gcgccgcacc gcgtccgcgc tcgggggtgg tttcgcgctg ctcctcttcc cgactggcca 28380 tttccttctc ctataggcag aaaaagatca tggagtcagt cgagaagaag gacagcctaa 28440 ccgccccctc tgagttcgcc accaccgcct ccaccgatgc cgccaacgcg cctaccacct 28500 tccccgtcga ggcacccccg cttgaggagg aggaagtgat tatcgagcag gacccaggtt 28560 ttgtaagcga agacgacgag gaccgctcag taccaacaga ggataaaaag caagaccagg 28620 acaacgcaga ggcaaacgag gaacaagtcg ggcgggggga cgaaaggcat ggcgactacc 28680 tagatgt ggg agacgacgtg ctgttgaagc atctgcagcg ccagtgcgcc attatctgcg 28740 acgcgttgca agagcgcagc gatgtgcccc tcgccatagc ggatgtcagc cttgcctacg 28800 aacgccacct attctcaccg cgcgtacccc ccaaacgcca agaaa acggc acatgcgagc 28860 ccaacccgcg cctcaacttc taccccgtat ttgccgtgcc agaggtgctt gccacctatc 28920 acatcttttt ccaaaactgc aagatacccc tatcctgccg tgccaaccgc agccgagcgg 28980 acaagcagct ggccttgcgg cagggcgctg tcatacctga tatcgcctcg ctcaacgaag 29040 tgccaaaaat ctttgagggt cttggacgcg acgagaagcg cgcggcaaac gctctgcaac 29100 aggaa aacag cgaaaatgaa agtcactctg gagtgttggt ggaactcgag ggtgacaacg 29160 cgcgcctagc cgtactaaaa cgcagcatcg aggtcaccca ctttgcctac ccggcactta 29220 acctaccccc caaggtcatg agcacagtca tgagtgagct gatcgtgcgc cgt gcgcagc 29280 ccctggagag ggatgcaaat ttgcaagaac aaacagagga gggcctaccc gcagttggcg 29340 acgagcagct agcgcgctgg cttcaaacgc gcgagcctgc cgacttggag gagcgacgca 29400 aactaatgat ggccgcagtg ctcgttaccg tggagcttga gtgcatgcag cggttctttg 29460 ctgacccgga gatgcagcgc aagctagagg aaacattgca ctacaccttt cgacagggct 29520 acgtacgcca ggcctgcaag atctcc 297 00 ccatgggcgt ttggcagcag tgcttggagg agtgcaacct caaggagctg cagaaactgc 29760 taaagcaaaa cttgaaggac ctatggacgg ccttcaacga gcgctccgtg gccgcgcacc cat taagtac cgcgaatgcc 30000 ctccgccgct ttggggccac tgctaccttc tgcagctagc caactacctt gcctaccact 30060 ctgacataat ggaagacgtg agcggtgacg gtctactgga gtgtcactgt cgctgcaacc 30120 tatgcacccc gcaccgctcc ctgg tttgca attcgcagct gcttaacgaa agtcaaatta 30180 tcggtacctt tgagctgcag ggtccctcgc ctgacgaaaa gtccgcggct ccggggttga 30240 aactcactcc ggggctgtgg acgtcggctt accttcgcaa atttgtacct gaggactacc 30300 acgcccacga gattaggttc tacgaagacc aatcccgccc gcctaatgcg gagcttaccg 30360 cctgcgtcat tacccagggc cacattcttg gccaattgca agccatcaac aaagcccg cc 30420 aagagtttct gctacgaaag ggacgggggg tttacttgga cccccagtcc ggcgaggagc 30480 tcaacccaat ccccccgccg ccgcagccct atcagcagca gccgcgggcc cttgcttccc 30540 aggatggcac ccaaaaagaa gctgcagctg ccgcc gccac ccacggacga ggaggaatac 30600 tgggacagtc aggcagagga ggttttggac gaggaggagg aggacatgat ggaagactgg 30660 gagagcctag acgaggaagc ttccgaggtc gaagaggtgt cagacgaaac accgtcaccc 30720 tcggtcgcat tcccctcgcc ggcgccccag aaatcggcaa ccggttccag catggctaca 30780 acctccgctc ctcaggcgcc gccggcactg cccgttcgcc gacccaaccg tagatgggac 30840 accactggaa ccagggccgg taagtccaag cagccgccgc cgttagccca agagcaacaa 30900 cagcgccaag gctaccgctc atggcgcggg cacaagaacg ccatagttgc ttgcttgcaa 30960 gactgtgggg gcaacatctc cttcgcccgc cgctttcttc tctaccatca cggcgtggcc 31020 ttcccccgta acatcctgca ttactaccgt catctctaca gcccatactg caccggcggc 31080 agcggcagca acagcagcgg ccacacagaa gcaaaggcga ccggatagca agactctgac 31140 aaagcccaag aaatccacag cggcggcagc agcaggagga ggagcgctgc gtctggcgcc 31200 caacgaaccc gtatcgaccc gcgagcttag aaacaggatt tttcccactc tgtatgctat 31260 atttcaacag agcaggggcc aagaacaaga gctgaaaata aaaaacaggt ctctgcgatc 31320 cctcacccgc agctgcctgt atcacaaaag cgaagatcag cttcggcgca cgctggaaga 31380 cgcggaggct ctcttcagta aatactgcgc gctgactctt aaggactagt ttcgcgccct 31440 ttctcaaatt taagcgcgaa aactacgtca tctccagcgg ccacacccgg cgccagcacc 31500 tgttgtcagc gccattatga gcaaggaaat tcccacgccc tacatgtgga gttaccagcc 31560 acaaatggga cttgcggctg gagctgccca agactactca acccgaataa actacatgag 31620 cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa accgaattct 31680 cctggaacag gcggctatta ccacc acacc tcgtaataac cttaatcccc gtagttggcc 31740 cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc ccagagacgc 31800 ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag 31860 ggt gcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag gtattcagct 31920 caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat ttcagatcgg 31980 cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc 32040 ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt ttgtgccatc 32100 ggtctacttt aac cccttct cgggacctcc cggccactat ccggatcaat ttattcctaa 32160 ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg gagaggcaga 32220 gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg cccgcgactc 3 2280 cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg cgcacggcgt 32340 ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta cccagcgccc 32400 cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca actgtcctaa 32460 ccctggatta catcaagatc ctctagttaa tgtcaggtcg cctaagtcga ttaactagag 32520 tacccgggga tcttattccc tttaactaat aaa aaaaaat aataaagcat cacttactta 32580 aaatcagtta gcaaatttct gtccagttta ttcagcagca cctccttgcc ctcctcccag 32640 ctctggtatt gcagcttcct cctggctgca aactttctcc acaatctaaa tggaatgtca 32700 gtttcctcct gt tcctgtcc atccgcaccc actatcttca tgttgttgca gatgaagcgc 32760 gcaagaccgt ctgaagatac cttcaacccc gtgtatccat atgacacgga aaccggtcct 32820 ccaactgtgc ctttcttac tcctcccttt gtatccccca atgggtttca agagagtccc 32880 cctggggtac tctctttgcg cctatccgaa cctctagtta cctccaatgg catgcttgcg 32940 ctcaaaatgg gcaacggcct ctctctggac gaggccca accttacctc ccaaaatgta 33000 accactgtga gcccacctct caaaaaaacc aagtcaaaca taaacctgga aatatctgca 33060 cccctcacag ttacctcaga agccctaact gtggctgccg ccgcacctct aatggtcgcg 33120 ggcaacacac tcaccatgca atcaca ggcc ccgctaaccg tgcacgactc caaacttagc 33180 attgccaccc aaggacccct cacagtgtca gaaggaaagc tagccctgca aacatcaggc 33240 cccctcacca ccaccgatag cagtaccctt actatcactg cctcaccccc tctaactact 33300 gccactggta gcttgggcat tgacttgaaa gagcccattt atacacaaaa tggaaaacta 33360 ggactaaagt acggggctcc tttgcatgta acagacgacc taaacacttt gaccgtagca 33420 actggtccag gtgtgactat taataatact tccttgcaaa ctaaagttac tggagccttg 33480 ggttttgatt cacaaggcaa tatgcaactt aatgtagcag gaggactaag gattgattct 33540 caaaacagac gccttatact tgatgttagt tatccgtttg atgctca aaa ccaactaaat 33600 ctaagactag gacagggccc tctttttata aactcagccc acaacttgga tattaactac 33660 aacaaaggcc tttacttgtt tacagcttca aacaattcca aaaagcttga ggttaaccta 33720 agcactgcca aggggttgat gtttgacgct acagccatag ccattaatgc aggagatggg 33780 cttgaatttg gttcacctaa tgcaccaaac acaaatcccc tcaaaacaaa aattggc cat 33840 ggcctagaat ttgattcaaa caaggctatg gttcctaaac taggaactgg ccttagtttt 33900 gacagcacag gtgccattac agtaggaaac aaaaataatg ataagctaac tttgtggacc 33960 ggaataaacc ctccacctaa ctgtcaaatt gtggaaaaca ctaatacaaa tgatggcaaa 34020 cttactttag tattagtaaa aaatggaggg cttgttaatg gctacgtgtc tctagttggt 34080 gtatcagaca ctgtgaacca aatgttcaca caaaagacag caaacatcca attaagatta 34140 tattttgact cttctggaaa tctattaact gaggaatcag acttaaaaat tccacttaaa 34200 aataaatctt ctacagcgac cagtgaaact gtagccagca gcaaagcctt tatgccaagt 34260 actac agctt atcccttcaa caccactact agggatagtg aaaactacat tcatggaata 34320 tgttactaca tgactagtta tgatagaagt ctatttccct tgaacatttc tataatgcta 34380 aacagccgta tgatttcttc caatgttgcc tatgccatac aatttgaatg gaatctaaat 34440 gcaagtgaat ctccagaaag caacatagct acgctgacca catccccctt tttcttttct 34500 tacattacag aagacgacaa ctaaagaatc gtttgtgtta tgtttcaacg tgtttatttt 34560 tcaattgcag aaaatttcaa gtcatttttc attcagtagt atagccccac caccacatag 34620 cttatacaga tcaccgtacc ttaatcaaac tcacagaacc ctagtattca acctgccacc 34680 tccctcccaa cacacagagt acacagtcct ttctccccgg ctggccttaa aaagcatcat 34740 atcatgggta acagacatat tcttaggtgt tatattccac acggtttcct gtcgagccaa 34800 acgctcatca gtgatattaa taaactcccc gggcagctca cttaagttca tgtcgctgtc 34860 cagctgctga gccacaggct gctgtccaac ttgcggttgc ttaacgggcg gcgaaggaga 34920 agtccacgcc tacatggggg tagagtcata atcgtgcatc aggatagggc ggtggtgctg 34980 cagcagcgcg cgaataaact gctgccgccg ccgctccgtc ctgcaggaat acaacatggc 35040 agtggtctcc tcagcgatga ttcgcaccgc ccgcagcata aggcgccttg tcctccgggc 35100 acagcagc gc accctgatct cacttaaatc agcacagtaa ctgcagcaca gcaccacaat 35160 attgttcaaa atcccacagt gcaaggcgct gtatccaaag ctcatggcgg ggaccacaga 35220 acccacgtgg ccatcatacc acaagcgcag gtagattaag tggcgacccc tcataaacac 35280 gct ggacata aacattacct cttttggcat gttgtaattc accacctccc ggtaccatat 35340 aaacctctga ttaaacatgg cgccatccac caccatccta aaccagctgg ccaaaacctg 35400 cccgccggct atacactgca gggaaccggg actggaacaa tgacagtgga gagcccagga 35460 ctcgtaacca tggatcatca tgctcgtcat gatatcaatg ttggcacaac acaggcacac 35520 gtgcatacac ttcctcagga ttacaagctc ct gtct caaaag gaggtagacg atccctactg tacggagtgc gccgagacaa 35760 ccgagatcgt gttggtcgta gtgtcatgcc aaatggaacg ccggacgtag tcatatttcc 35820 tgaagcaaaa ccaggtgcgg gcgtgacaaa cagatctgcg tctccggtct cgccgcttag 35880 atcgctctgt gtagtagttg tagtatatcc actctctcaa agcatccagg cgccccctgg 35940 cttcgggttc tatgtaaact ccttcatgcg ccgctgccct gataacatcc accaccgcag 36000 aataagccac acccagccaa cctacacatt cgttctgcga gtcacacacg ggaggagcgg 36060 gaagagctgg aagaaccatg tttttttttt tattccaaaa gattatccaa aacctcaaaa 36120 tgaagatcta ttaagtgaac gc gctcccct ccggtggcgt ggtcaaactc tacagccaaa 36180 gaacagataa tggcatttgt aagatgttgc acaatggctt ccaaaaggca aacggccctc 36240 acgtccaagt ggacgtaaag gctaaaccct tcagggtgaa tctcctctat aaacattcca 36300 gcaccttcaa ccatgcccaa ataattctca tctcgccacc ttctcaatat atctctaagc 36360 aaatcccgaa tattaagtcc ggccattgta aaaatctgct ccagagcg cc ctccaccttc 36420 agcctcaagc agcgaatcat gattgcaaaa attcaggttc ctcacagacc tgtataagat 36480 tcaaaagcgg aacattaaca aaaataccgc gatcccgtag gtcccttcgc agggccagct 36540 gaacataatc gtgcaggtct gcacggacca gcgcggccac ttccccgcca ggaaccatga 36600 caaaagaacc cacactgatt atgacacgca tactcggagc tatgctaacc agcgtagccc 36660 cgatgtaagc ttgttgcatg ggcggcgata taaaatgcaa ggtgctgctc aaaaaatcag 36720 gcaaagcctc gcgcaaaaaa gaaagcacat cgtagtcatg ctcatgcaga taaaggcagg 36780 taagctccgg aaccaccaca gaaaaagaca ccatttttct ctcaaacatg tctgcgggtt 36840 tctgcataaa cacaaaataa aataacaaaa aaacatttaa acattagaag cctgtcttac 36900 aacaggaaaa acaaccctta taagcataag acggactacg gccatgccgg cgtgaccgta 36960 aaaaaactgg tcaccgtgat taaaaagcac caccgacagc t cctcggtca tgtccggagt 37020 cataatgtaa gactcggtaa acacatcagg ttgattcaca tcggtcagtg ctaaaaagcg 37080 accgaaatag cccgggggaa tacatacccg caggcgtaga gacaacatta cagcccccat 37140 aggaggtata acaaaattaa taggagagaa aaacacataa acacctgaaa aaccctcctg 37200 cctaggcaaa atagcaccct cccgctccag aacaacatac agcgcttcca cagcggcagc 37260 cataacagtc agccttacc a gtaaaaaaga aaacctatta aaaaaacacc actcgacacg 37320 gcaccagctc aatcagtcac agtgtaaaaa agggccaagt gcagagcgag tatatatagg 37380 actaaaaaat gacgtaacgg ttaaagtcca caaaaaacac ccagaaaacc gcacgcgaac 37 440 ctacgcccag aaacgaaagc caaaaaaccc acaacttcct caaatcgtca cttccgtttt 37500 cccacgttac gtcacttccc attttaagaa aactacaatt cccaacacat acaagttact 37560 ccgccctaaa acctacgtca cccgccccgt tcccacgccc cgcgccacgt cacaaactcc 37620accccctcat tatcatattg gcttcaatcc aaaataaggt atattattga tgatg 37675 <210> 27 <211> 34736 <212> DNA <213> artificial sequence <220> <223> #3 vector <400> 27 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg t ggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gt gttatca tagcgcgtaa tactgtaata gtaatcaatt 360 acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420 ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt 480 cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540 actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600 aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660 acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720 tacatcaatg ggcgtggata gcggtttgac tcac ggggat ttccaagtct ccaccccatt 780 gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840 aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900 agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960 cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020 agacaccggg accgatccag cctccgattt gccaccatgt ttgtgttcct ggtgctgctg 1080 ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc tcctgcctac 1140 accaactcct tcaccaggggg agtctactac cctgacaagg tgt tcaggtc ctctgtgctg 1200 cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt ccatgccatc 1260 catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc attcaatgat 1320 ggaggtctact ttgccagcac agagaagagc aacatcatca ggggctggat ttttggcacc 1380 accctggaca gcaagaccca gtccctgctg attgtgaaca atgccaccaa tgtggt gatt 1440 aaggtgtgg agttccagtt ctgtaatgac ccattcctgg gagtctacta ccacaagaac 1500 aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa ctgtaccttt 1560 gaatatgtga gccaaccatt cctgatggac ttggagggca agcagg gcaa cttcaagaac 1620 ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag caaacacaca 1680 ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc actggtggac 1740 ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca caggtcctac 1800 ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta ctatgtgg gc 1860 tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat cacagatgct 1920 gtggactgg ccctggaccc actgtctgag accaagtgta ccctgaaatc cttcacagtg 1980 gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag cattgt gagg 2040 tttccaaaca tcaccaacct gtgtccattt ggagaggtgt tcaatgccac caggtttgcc 2100 tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta ctctgtgctc 2160 tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac caaactgaat 2220 gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga tgaggtgaga 22 80 cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact gcctgatgac 2340 ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt gggaggcaac 2400 tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga gagggacatc 2460 agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg cttcaactgt 2520 tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta ccaaccatac 2580 agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgg tggaccaaag 2640 aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg actgacaggc 2700 acaggagtgc tgacagagag caacaagaag tcctgccat tccaacagtt tggcagggac 2760 attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct ggacatcaca 2820 ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag caaccaggtg 2880 gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca tgctgaccaa 2940 cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac cagggctggc 3000 tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc aattggagca 3060 ggcatctgg cctcctacca gacccagacc ggtggcggtg ggtcgaggtc tgtggcaagc 3120 cagagcatca ttgcc tacac aatgagtctg ggagcagaga actctgtggc ttacagcaac 3180 aacagcattg ccatcccaac caacttcacc atctctgtga ccacagagat tctgcctgtg 3240 agtatgacca agacctctgt ggactgtaca atgtatatct gtggagacag cacagagtgt 3300 agcaacctgc tgctcca ata tggctccttc tgtacccaac ttaacagggc tctgacaggc 3360 attgctgtgg aacaggacaa gaacacccag gaggtgtttg cccaggtgaa gcagatttac 3420 aagacacctc caatcaagga ctttggaggc ttcaacttca gccagattct gcctgaccca 3480 agcaagccaa gcaagaggtc cttcattgag gacctgctgt tcaacaaggt gaccctggct 3540 gatgctggct tcatcaagca atatggagac tgtctgggag acattgctgc cagggacctg 3600 atttgtgccc agaagttcaa tggactgaca gtgctgcctc cactgctgac agatgagatg 3660 attgcccaat acacctctgc cctgctggct ggcaccatca cctctggctg gacctttgga 3720 gcaggagcag ccctcca aat cccatttgct atgcagatgg cttacaggtt caatggcatt 3780 ggagtgaccc agaatgtgct ctatgagaac cagaaactga ttgccaacca gttcaactct 3840 gccattggca agattcagga ctccctgtcc agcacagcct ctgccctggg caaactccaa 3900 gatgtggtga accagaatgc ccaggctctg aacaccctgg tgaagcaact ttccagcaac 3960 tttggagcca tctcctctgt gctgaatgac atcctgagca g actggacaa ggtggaggct 4020 gaggtccaga ttgacagact gattacaggc agactccaat ccctccaaac ctatgtgacc 4080 caacaactta tcagggctgc tgagattagg gcatctgcca acctggctgc caccaagatg 4140 agtgagtgtg tgctgggaca aagcaagagg gtggactt ct gtggcaaggg ctaccacctg 4200 atgagttttc cacagtctgc ccctcatgga gtggtgttcc tgcatgtgac ctatgtgcct 4260 gcccaggaga agaacttcac cacagcccct gccatctgcc atgatggcaa ggctcacttt 4320 ccaagggagg gagtgtttgt gagcaatggc acccactggt ttgtgaccca gaggaacttc 4380 tatgaaccac agattatcac cacagacaac acctttgtgt ctggcaactg tgatgt ggtg 4440 attggcattg tgaacaacac agtctatgac ccactccaac ctgaactgga ctccttcaag 4500 gaggaactgg acaaatactt caagaaccac accagccctg atgtggacct gggagacatc 4560 tctggcatca atgcctctgt ggtgaacatc cagaaggaga ttgacagact gaatgagg tg 4620 gctaagaacc tgaatgagtc cctgattgac ctccaagaac tgggcaaata tgaacaatac 4680 atcaagtggc catgaaaatt gatcataatc agccatacca catttgtaga ggttttactt 4740 gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt 4800 gttgttaact tgttattgc agcttataat ggttacaaat aaagcaatag catcacaaat 48 Cat gagcacc aactcgtttg 5040 atggaagcat tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc 5100 agaatgtgat gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct 5160 tgacctacga gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag 5220 ccgctgcagc caccgcccgc gggattgtga ctgactttgc tttcctgagc cc gcttgcaa 5280 gcagtgcagc ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat 5340 tggattcttt gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc 5400 aggtttctgc cctgaaggct tcct cccctc ccaatgcggt ttaaaacata aataaaaaac 5460 cagactctgt ttggatttgg atcaagcaag tgtcttgctg tctttattta ggggttttgc 5520 gcgcgcggta ggcccgggac cagcggtctc ggtcgttgag ggtcctgtgt attttttcca 5580 ggacgtggta aaggtgactc tggatgttca gatacatggg cataagcccg tctctggggt 5640 ggaggtagca ccactgcaga gcttcatgct gcggggtggt gttgtagatg atccagtcgt 5700 agca ggagcg ctgggcgtgg tgcctaaaaa tgtctttcag tagcaagctg attgccaggg 5760 gcaggccctt ggtgtaagtg tttacaaagc ggttaagctg ggatgggtgc atacgtgggg 5820 atatgagatg catcttggac tgtattttta ggttggctat gttcccagcc atatccct cc 5880 ggggattcat gttgtgcaga accaccagca cagtgtatcc ggtgcacttg ggaaatttgt 5940 catgtagctt agaaggaaat gcgtggaaga acttggagac gcccttgtga cctccaagat 6000 tttccatgca ttcgtccata atgatggcaa tgggcccacg ggcggcggcc tgggcgaaga 6060 tatttctggg atcactaacg tcatagttgt gttccaggat gagatcgtca taggccattt 6120 ttacaaagcg cggg cggagg gtgccagact gcggtataat ggttccatcc ggcccagggg 6180 cgtagttacc ctcacagatt tgcatttccc acgctttgag ttcagatggg gggatcatgt 6240 ctacctgcgg ggcgatgaag aaaacggttt ccggggtagg ggagatcagc tgggaagaaa 63 00 gcaggttcct gagcagctgc gacttaccgc agccggtggg cccgtaaatc acacctatta 6360 ccggctgcaa ctggtagtta agagagctgc agctgccgtc atccctgagc aggggggcca 6420 cttcgttaag catgtccctg actcgcatgt tttccctgac caaatccgcc agaaggcgct 6480 cgccgcccag cgatagcagt tcttgcaagg aagcaaagtt tttcaacggt ttgagaccgt 6540 ccgccgtagg catgcttttg agcgtttgac caagcagttc caggcggtcc cacagctcgg 6600 tcacctgctc tacggcatct cgatccagca tatctcctcg tttcgcgggt tggggcggct 6660 ttcgctgtac ggcagtagtc ggtgctcgtc cagacgggcc agggtcatgt ctttccacgg 6 720 gcgcagggtc ctcgtcagcg tagtctgggt cacggtgaag gggtgcgctc cgggctgcgc 6780 gctggccagg gtgcgcttga ggctggtcct gctggtgctg aagcgctgcc ggtcttcgcc 6840 ctgcgcgtcg gccaggtagc atttgaccat ggtgtcatag tccagcccct ccgcggcgtg 6900 gcccttggcg cgcagcttgc ccttggagga ggcgccgcac gaggggcagt gcagactttt 6960 gagggcgtag agcttgggcg c gagaaatac cgattccggg gagtaggcat ccgcgccgca 7020 ggccccgcag acggtctcgc attccacgag ccaggtgagc tctggccgtt cggggtcaaa 7080 aaccaggttt cccccatgct ttttgatgcg tttcttacct ctggtttcca tgagccggtg 7140 tccacgctcg gtgacgaaaa ggctgtccgt gtccccgtat acagacttga gaggcctgtc 7200 ctcgagcggt gttccgcggt cctcctcgta tagaaactcg gaccactctg agacaaaggc 7260 tcgcgtccag gccagcacga aggaggctaa gtgggagggg tagcggtcgt tgtccactag 7320 ggggtccact cgctccaggg tgtgaagaca catgtcgccc tcttcggcat caaggaaggt 7380 gattggtttg taggtgtagg ccacgtgacc gggtgttcct gaagggggg c tataaaaggg 7440 ggtgggggcg cgttcgtcct cactctcttc cgcatcgctg tctgcgaggg ccagctgttg 7500 gggtgagtac tccctctgaa aagcgggcat gacttctgcg ctaagattgt cagtttccaa 7560 aaacgaggag gatttgatat tcacctggcc cgcggtgatg cctttgaggg tggccgcatc 7620 catctggtca gaaaagacaa tctttttgtt gtcaagcttg gtggcaaacg acccgtagag 7680 ggcgttggac agcaacttgg cgatggagcg cagggtttgg tttttgtcgc gatcggcgcg 7740 ctccttggcc gcgatgttta gctgcacgta ttcgcgcgca acgcaccgcc attcgggaaa 7800 gacggtggtg cgctcgtcgg gcaccaggtg cacgc gccaa ccgcggttgt gcagggtgac 7860 aaggtcaacg ctggtggcta cctctccgcg taggcgctcg ttggtccagc agaggcggcc 7920 gcccttgcgc gagcagaatg gcggtagggg gtctagctgc gtctcgtccg gggggtctgc 7980 gtccacggta aaga ccccgg gcagcaggcg cgcgtcgaag tagtctatct tgcatccttg 8040 caagtctagc gcctgctgcc atgcgcgggc ggcaagcgcg cgctcgtatg ggttgagtgg 8100 gggaccccat ggcatggggt gggtgagcgc ggaggcgtac atgccgcaaa tgtcgtaaac 8160 gtagaggggc tctctgagta ttccaagata tgtagggtag catcttccac cgcggatgct 8220 ggcgcgcacg taatcgtata gttcgtgcga gggagcgagg aggtcgggac cgaggt tgct 8280 acgggcgggc tgctctgctc ggaagactat ctgcctgaag atggcatgtg agttggatga 8340 tatggttgga cgctggaaga cgttgaagct ggcgtctgtg agacctaccg cgtcacgcac 8400 gaaggaggcg taggagtcgc gcagcttgtt gaccagctcg g cggtgacct gcacgtctag 8460 ggcgcagtag tccagggttt ccttgatgat gtcatactta tcctgtccct tttttttcca 8520 cagctcgcgg ttgaggacaa actcttcgcg gtctttccag tactcttgga tcggaaaccc 8580 gtcggcctcc gaacggtaag agcctagcat gtagaactgg ttgacggcct ggtaggcgca 8640 gcatcccttt tctacgggta gcgcgtatgc ctgcgcggcc ttccggagcg aggtgtgggt 8 700 gagcgcaaag gtgtccctga ccatgacttt gaggtactgg tatttgaagt cagtgtcgtc 8760 gcatccgccc tgctcccaga gcaaaaagtc cgtgcgcttt ttggaacgcg gatttggcag 8820 ggcgaaggtg acatcgttga agagtatctt tcccgcgc ga ggcataaagt tgcgtgtgat 8880 gcggaagggt cccggcacct cggaacggtt gttaattacc tgggcggcga gcacgatctc 8940 gtcaaagccg ttgatgttgt ggcccacaat gtaaagttcc aagaagcgcg ggatgccctt 9000 gatggaaggc aattttttaa gttcctcgta ggtgagctct tcaggggagc tgagcccgtg 9060 ctctgaaagg gcccagtctg caagatgagg gttggaagcg acgaatgagc tccacaggtc 9120 acggg ccatt agcatttgca ggtggtcgcg aaaggtccta aactggcgac ctatggccat 9180 tttttctggg gtgatgcagt agaaggtaag cgggtcttgt tcccagcggt cccatccaag 9240 gttcgcggct aggtctcgcg cggcagtcac tagaggctca tctccgccga act tcatgac 9300 cagcatgaag ggcacgagct gcttcccaaa ggcccccatc caagtatagg tctctacatc 9360 gtaggtgaca aagagacgct cggtgcgagg atgcgagccg atcgggaaga actggatctc 9420 ccgccaccaa ttggaggagt ggctattgat gtggtgaaag tagaagtccc tgcgacgggc 9480 cgaacactcg tgctggcttt tgtaaaaacg tgcgcagtac tggcagcggt gcacgggctg 9540 tacatcctgc acgagg ttga cctgacgacc gcgcacaagg aagcagagtg ggaatttgag 9600 cccctcgcct ggcgggtttg gctggtggtc ttctacttcg gctgcttgtc cttgaccgtc 9660 tggctgctcg aggggagtta cggtggatcg gaccaccacg ccgcgcgagc ccaaagtcc a 9720 gatgtccgcg cgcggcggtc ggagcttgat gacaacatcg cgcagatggg agctgtccat 9780 ggtctggagc tcccgcggcg tcaggtcagg cgggagctcc tgcaggttta cctcgcatag 9840 acgggtcagg gcgcgggcta gatccaggtg atacctaatt tccaggggct ggttggtggc 9900 ggcgtcgatg gcttgcaaga ggccgcatcc ccgcggcgcg actacggtac cgcgcggcgg 9960 gcggtgggcc gcgggggtgt ccttggatga tgcatctaaa agcggtgacg cgggcgagcc 10020 cccggaggta gggggggctc cggacccgcc gggagagggg gcaggggcac gtcggcgccg 10080 cgcgcgggca ggagctggtg ctgcgcgcgt aggttgctgg cgaacgcgac gacgcggcgg 10140 ttgatctcct gaatctggcg cctctgcgtg aagacgacgg gcccggtgag cttgaacctg 10200 aaagagagtt cgacagaatc aatttcggtg tcgttgacgg cggcctggcg caaaatctcc 10260 tgcacgtctc ctgagttgtc ttgataggcg atctcggcca tgaactgctc gatctcttcc 10320 tcctggagat ctccgcgtcc ggctcgctcc acggtggcgg cgaggtcgtt ggaaatgcgg 10380 gccatgagct gcgagaaggc gttgaggcct ccctcgttcc agacgcggct gtagaccacg 10440 cccccttcgg catcgcgggc gcgcatgacc acctgcgcga gattgagctc cacgtgccgg 10500 gcgaagacgg cgtagtttcg caggcgctga aagaggtagt tgagggtggt ggcggtgtgt 10560 tctgccacga agaagtacat aacccagcgt cgcaacgtgg attcgttgat atcccccaag 10620 gcctcaaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa ctgggagttg 10680 cgcgccgaca cggttaactc ctcctccaga agacggatga gctcggcgac agtgtcgcgc 10740 acctcgcgct caaaggctac aggggcctct tcttcttctt caatctcctc ttccataagg 10800 gcctcccctt cttcttcttc tggcggcggt gggggagggg ggacacggcg gcgacgacgg 10860 cgcaccggga ggcggtcgac aaagcgctcg atcatctccc cgcggcgacg gcgcatggtc 10920 tcggtgacgg cgcggccgtt ctcgcggggg cgcagttgga agacgccgcc cgtcatgtcc 10980 cggttatggg ttggcggggg gctgccatgc ggcagggata cggcgctaac gatgcatctc 11040 aacaattgtt gtgtaggtac tccgccgccg agggacctga gcgagtccgc atcgaccgga 11100 tcggaaaacc tctcgagaaa ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc 11160 gtggcgggcg gcagcgggcg gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg 11220 taattaaagt aggcggtctt gagacggcgg atggtcgaca gaagcaccat gt ccttgggt 11280 ccggcctgct gaatgcgcag gcggtcggcc atgccccagg cttcgttttg acatcggcgc 11340 aggtctttgt agtagtcttg catgagcctt tctaccggca cttcttcttc tccttcctct 11400 tgtcctgcat ctcttgcat c tatcgctgcg gcggcggcgg agtttggccg taggtggcgc 11460 cctcttcctc ccatgcgtgt gaccccgaag cccctcatcg gctgaagcag ggctaggtcg 11520 gcgacaacgc gctcggctaa tatggcctgc tgcacctgcg tgagggtaga ctggaagtca 11580 tccatgtcca caaagcggtg gtatgcgccc gtgttgatgg tgtaagtgca gttggccata 11640 acggaccagt taacggtctg gtgacccggc tgcgagagct cggtgtacct gagacgc gag 11700 taagccctcg agtcaaatac gtagtcgttg caagtccgca ccaggtactg gtatcccacc 11760 aaaaagtgcg gcggcggctg gcggtagagg ggccagcgta gggtggccgg ggctccgggg 11820 gcgagatctt ccaacataag gcgatgatat ccgtagat gt acctggacat ccaggtgatg 11880 ccggcggcgg tggtggaggc gcgcggaaag tcgcggacgc ggttccagat gttgcgcagc 11940 ggcaaaaagt gctccatggt cgggacgctc tggccggtca ggcgcgcgca atcgttgacg 12000 ctctagcgtg caaaaggaga gcctgtaagc ggggcactctt ccgtggtctg gtggataaat 12060 tcgcaagggt atcatggcgg acgaccgggg ttcgagcccc gtatccggcc gtccgccgtg 12120 atc catgcgg ttaccgcccg cgtgtcgaac ccaggtgtgc gacgtcagac aacgggggag 12180 tgctcctttt ggcttccttc caggcgcggc ggctgctgcg ctagcttttt tggccactgg 12240 ccgcgcgcag cgtaagcggt taggctggaa agcgaaagca ttaagtggct cgctccctgt 12300 agccggaggg ttattttcca agggttgagt cgcgggaccc ccggttcgag tctcggaccg 12360 gccggactgc ggcgaacggg ggtttgcctc cccgtcatgc aagaccccgc ttgcaaattc 12420 ctccggaaac agggacgagc cccttttttg cttttcccag atgcatccgg tgctgcggca 12480 gatgcgcccc cctcctcagc agcggcaaga gcaagagcag cggcagacat gcagggcacc 12540 ctcccctcct cc taccgcgt caggaggggc gacatccgcg gttgacgcgg cagcagatgg 12600 tgattacgaa cccccgcggc gccgggcccg gcactacctg gacttggagg agggcgaggg 12660 cctggcgcgg ctaggagcgc cctctcctga gcggcaccca agggtgcagc tgaagcgt ga 12720 tacgcgtgag gcgtacgtgc cgcggcagaa cctgtttcgc gaccgcgagg gagaggagcc 12780 cgaggagatg cgggatcgaa agttccacgc agggcgcgag ctgcggcatg gcctgaatcg 12840 cgagcggttg ctgcgcgagg aggactttga gcccgacgcg cgaaccggga ttagtcccgc 12900 gcgcgcacac gtggcggccg ccgacctggt aaccgcatac gagcagacgg tgaaccagga 12960 gattaacttt caaaaaag ct ttaacaacca cgtgcgtacg cttgtggcgc gcgaggaggt 13020 ggctatagga ctgatgcatc tgtgggactt tgtaagcgcg ctggagcaaa acccaaatag 13080 caagccgctc atggcgcagc tgttccttat agtgcagcac agcagggaca acgaggcatt 131 40 cagggatgcg ctgctaaaca tagtagagcc cgagggccgc tggctgctcg atttgataaa 13200 catcctgcag agcatagtgg tgcaggagcg cagcttgagc ctggctgaca aggtggccgc 13260 catcaactat tccatgctta gcctgggcaa gttttacgcc cgcaagatat accatacccc 13320 ttacgttccc atagacaagg aggtaaagat cgaggggttc tacatgcgca tggcgctgaa 13380 ggtgcttacc ttgagcgacg acctgggcgt ttatcgcaac g agcgcatcc acaaggccgt 13440 gagcgtgagc cggcggcgcg agctcagcga ccgcgagctg atgcacagcc tgcaaagggc 13500 cctggctggc acgggcagcg gcgatagaga ggccgagtcc tactttgacg cgggcgctga 13560 cctgcgctgg gcccca agcc gacgcgccct ggaggcagct ggggccggac ctgggctggc 13620 ggtggcaccc gcgcgcgctg gcaacgtcgg cggcgtggag gaatatgacg aggacgatga 13680 gtacgagcca gaggacggcg agtactaagc ggtgatgttt ctgatcagat gatgcaagac 13740 gcaacggacc cggcggtgcg ggcggcgctg cagagccagc cgtccggcct taactccacg 13800 gacgactggc gccaggtcat ggaccgcatc atgtcgctga ctgcgcg caa tcctgacgcg 13860 ttccggcagc agccgcaggc caaccggctc tccgcaattc tggaagcggt ggtcccggcg 13920 cgcgcaaacc ccacgcacga gaaggtgctg gcgatcgtaa acgcgctggc cgaaaacagg 13980 gccatccggc ccgacgaggc cggcctggtc tacgacgcgc tgcttcagcg cgtggctcgt 14040 tacaacagcg gcaacgtgca gaccaacctg gaccggctgg tgggggatgt gcgcgaggcc 14100 gtggcgcagc gtgagcgcgc gcagcagcag ggcaacctgg gctccatggt tgcactaaac 14160 gccttcctga gtacacagcc cgccaacgtg ccgcggggac aggaggacta caccaacttt 14220 gtgagcgcac tgcggctaat ggtgactgag acaccgcaaa gtgaggt gta ccagtctggg 14280 ccagactatt ttttccagac cagtagacaa ggcctgcaga ccgtaaacct gagccaggct 14340 ttcaaaaaact tgcaggggct gtggggggtg cgggctccca caggcgaccg cgcgaccgtg 14400 tctagcttgc tgacgcccaa ctcgcgcctg ttgctgctgc taatagcgcc cttcacggac 14460 agtggcagcg tgtcccggga cacataccta ggtcacttgc tgacactgta ccgcgaggcc 14520 ataggtcagg cgcatgtgga cgagcatact ttccaggaga ttacaagtgt cagccgcgcg 14580 ctggggcagg aggacacggg cagcctggag gcaaccctaa actacctgct gaccaaccgg 14640 cggcagaaga tcccctcgtt gcacagttta aacagcgagg aggagcgcat tttgcgctac 14700 gtgca gcaga gcgtgagcct taacctgatg cgcgacgggg taacgcccag cgtggcgctg 14760 gacatgaccg cgcgcaacat ggaaccgggc atgtatgcct caaaccggcc gtttatcaac 14820 cgcctaatgg actacttgca tcgcgcggcc gccgtgaacc ccgagtattt caccaat gcc 14880 atcttgaacc cgcactggct accgccccct ggtttctaca ccgggggatt cgaggtgccc 14940 gagggtaacg atggattcct ctgggacgac atagacgaca gcgtgttttc cccgcaaccg 15000 cagaccctgc tagagttgca acagcgcgag caggcagagg cggcgctgcg aaaggaaagc 15060 ttccgcaggc caagcagctt gtccgatcta ggcgctgcgg ccccgcggtc agatgctagt 1512 0 agcccatttc caagcttgat agggtctctt accagcactc gcaccacccg cccgcgcctg 15180 ctgggcgagg aggagtacct aaacaactcg ctgctgcagc cgcagcgcga aaaaaacctg 15240 cctccggcat ttcccaacaa cgggatagag agcctagtgg acaagatga g tagatggaag 15300 acgtacgcgc aggagcacag ggacgtgcca ggcccgcgcc cgcccacccg tcgtcaaagg 15360 cacgaccgtc agcggggtct ggtgtgggag gacgatgact cggcagacga cagcagcgtc 15420 ctggatttgg gagggagtgg caacccgttt gcgcaccttc gccccaggct ggggagaatg 15480 ttttaaaaaa aaaaaagcat gatgcaaaat aaaaaactca ccaaggccat ggcaccgagc 15540 gttggttttc ttgtattccc cttagtatgc ggcgcgcggc gatgtatgag gaaggtcctc 15600 ctccctccta cgagagtgg gtgagcgcgg cgccagtggc ggcggcgctg ggttctccct 15660 tcgatgctcc cctggacccg ccgtttgtgc ctccgcggta cctgc ggcct accgggggga 15720 gaaacagcat ccgttactct gagttggcac ccctattcga caccacccgt gtgtacctgg 15780 tggacaacaa gtcaacggat gtggcatccc tgaactacca gaacgaccac agcaactttc 15840 tgaccacggt cattcaaaac aatgactaca gcccggggga ggcaagcaca cagaccatca 15900 atcttgacga ccggtcgcac tggggcggcg acctgaaaac catcctgcat accaacatgc 15960 caatgtgaa cgagttcatg tttaccaata agtttaa ggc gcgggtgatg gtgtcgcgct 16020 tgcctactaa ggacaatcag gtggagctga aatacgagtg ggtggagttc acgctgcccg 16080 agggcaacta ctccgagacc atgaccatag accttatgaa caacgcgatc gtggagcact 16140 acttgaaagt gggcagaca g aacggggttc tggaaagcga catcggggta aagtttgaca 16200 cccgcaactt cagactgggg tttgaccccg tcactggtct tgtcatgcct ggggtatata 16260 caaacgaagc cttccatcca gacatcattt tgctgccagg atgcggggtg gacttcaccc 16320 acagccgcct gagcaacttg ttgggcatcc gcaagcggca acccttccag gagggcttta 16380 ggatcaccta cgatgatctg gagggtggta acattcccgc actgtt ggat gtggacgcct 16440 accaggcgag cttgaaagat gacaccgaac agggcggggg tggcgcaggc ggcagcaaca 16500 gcagtggcag cggcgcggaa gagaactcca acgcggcagc cgcggcaatg cagccggtgg 16560 aggacatgaa cgatcatgcc attcgcgg cg acacctttgc cacacgggct gaggagaagc 16620 gcgctgaggc cgaagcagcg gccgaagctg ccgcccccgc tgcgcaaccc gaggtcgaga 16680 agcctcagaa gaaaccggtg atcaaacccc tgacagagga cagcaagaaa cgcagttaca 16740 acctaataag caatgacagc accttcaccc agtaccgcag ctggtacctt gcatacaact 16800 acggcgaccc tcagaccgga atccgctcat ggaccctgct ttgcactcct gacg taacct 16860 gcggctcgga gcaggtctac tggtcgttgc cagacatgat gcaagacccc gtgaccttcc 16920 gctccacgcg ccagatcagc aactttccgg tggtgggcgc cgagctgttg cccgtgcact 16980 ccaagagctt ctacaacgac caggccgtct act ccca act catccgccag tttacctctc 17040 tgacccacgt gttcaatcgc tttcccgaga accagatttt ggcgcgcccg ccagccccca 17100 ccatcaccac cgtcagtgaa aacgttcctg ctctcacaga tcacgggacg ctaccgctgc 17160 gcaacagcat cggaggagtc cagcgagtga ccattactga cgccagacgc cgcacctgcc 17220 cctacgttta caaggccctg ggcatagtct cgccgcgcgt cctatcgagc cgcacttttt 17280 gagcaagcat gtccatcctt atatcgccca gcaataacac aggctggggc ctgcgcttcc 17340 caagcaagat gtttggcggg gccaagaagc gctccgacca acacccagtg cgcgtgcgcg 17400 ggcactaccg cgcgccctgg ggcgcgcaca aacgcgg ccg cactgggcgc accaccgtcg 17460 atgacgccat cgacgcggtg gtggaggagg cgcgcaacta cacgcccacg ccgccaccag 17520 tgtccacagt ggacgcggcc attcagaccg tggtgcgcgg agcccggcgc tatgctaaaa 17580 tgaagagacg gcggaggcgc gtagcacgtc gccaccgccg ccgacccggc actgccgccc 17640 aacgcgcggc ggcggccctg cttaaccgcg cacgtcgcac cggccgacgg gcgg ccatgc 17700 gggccgctcg aaggctggcc gcgggtattg tcactgtgcc ccccaggtcc aggcgacgag 17760 cggccgccgc agcagccgcg gccattagtg ctatgactca gggtcgcagg ggcaacgtgt 17820 attgggtgcg cgactcggtt agcggcctgc gcgtgcccgt gcgcacccgc cccccgcgca 17880 actagattgc aagaaaaaac tacttagact cgtactgttg tatgtatcca gcggcggcgg 17940 cgcgcaacga agctatgtcc aagcgcaaaa tcaaagaaga gatgctccag gtcatcgcgc 18000 cggagatcta tggccccccg aagaaggaag agcaggatta caagccccga aagctaaagc 18060 gggtcaaaaa gaaaaagaaa gatgatgatg atgaacttga cgacgaggtg gaactgctgc 18120 acgctacc gc gcccaggcga cgggtacagt ggaaaggtcg acgcgtaaaa cgtgttttgc 18180 gacccggcac caccgtagtc tttacgcccg gtgagcgctc cacccgcacc tacaagcgcg 18240 tgtatgatga ggtgtacggc gacgaggacc tgcttgagca gccaac gag cgcctcgggg 18300 agtttgccta cggaaagcgg cataaggaca tgctggcgtt gccgctggac gagggcaacc 18360 caacacctag cctaaagccc gtaacactgc agcaggtgct gcccgcgctt gcaccgtccg 18420 aagaaaagcg cggcctaaag cgcgagtctg gtgacttggc acccaccgtg cagctgatgg 18480 tacccaagcg ccagcgactg gaagatgtct tggaaaaaat gaccgtggaa cctgggctgg 18540 agcccgaggt ccgc gtgcgg ccaatcaagc aggtggcgcc gggactgggc gtgcagaccg 18600 tggacgttca gatacccact accagtagca ccagtattgc caccgccaca gagggcatgg 18660 agacacaaac gtccccggtt gcctcagcgg tggcggatgc cgcggtgcag gcggtcgctg 187 20 cggccgcgtc caagacctct acggaggtgc aaacggaccc gtggatgttt cgcgtttcag 18780 ccccccggcg cccgcgccgt tcgaggaagt acggcgccgc cagcgcgcta ctgcccgaat 18840 atgccctaca tccttccatt gcgcctaccc ccggctatcg tggctacacc taccgcccca 18900 gaagacgagc aactacccga cgccgaacca ccactggaac ccgccgccgc cgtcgccgtc 18960 gccagcccgt gctggccccg atttccgtgc g cagggtggc tcgcgaagga ggcaggaccc 19020 tggtgctgcc aacagcgcgc taccacccca gcatcgttta aaagccggtc tttgtggttc 19080 ttgcagatat ggccctcacc tgccgcctcc gtttcccggt gccgggattc cgaggaagaa 19140 t gcaccgtag gaggggcatg gccggccacg gcctgacggg cggcatgcgt cgtgcgcacc 19200 accggcggcg gcgcgcgtcg caccgtcgca tgcgcggcgg tatcctgccc ctccttattc agaat ggaag acatcaactt tgcgtctctg 19440 gccccgcgac acggctcgcg cccgttcatg ggaaactggc aagatatcgg caccagcaat 19500 atgagcggtg gcgccttcag ctggggctcg ctgtggagcg gcattaaaaa tttcggttcc 19560 accgttaaga actat ggcag caaggcctgg aacagcagca caggccagat gctgagggat 19620 aagttgaaag agcaaaattt ccaacaaaag gtggtagatg gcctggcctc tggcattagc 19680 ggggtggtgg acctggccaa ccaggcagtg caaaataaga ttaacagtaa gcttgatccc 19740 cgccctcccg tagaggagcc tccaccggcc gtggagacag tgtctccaga ggggcgtggc 19800 gaaaagcgtc cgcgccccga cagggaagaa actctggtga cgcaaataga cga gcctccc 19860 tcgtacgagg aggcactaaa gcaaggcctg cccaccaccc gtcccatcgc gcccatggct 19920 accggagtgc tgggccagca cacacccgta acgctggacc tgcctccccc cgccgacacc 19980 cagcagaaac ctgtgctgcc aggcccgacc gccgt tgttg taacccgtcc tagccgcgcg 20040 tccctgcgcc gcgccgccag cggtccgcga tcgttgcggc ccgtagccag tggcaactgg 20100 caaagcacac tgaacagcat cgtgggtctg ggggtgcaat ccctgaagcg ccgacgatgc 20160 ttctgatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 20220 ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgcc gcagtg 20280 gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 20340 gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 20400 ggcgcctacg cacgacgtga ccacagaccg gtccca gcgt ttgacgctgc ggttcatccc 20460 tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20520 taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20580 ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20640 aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 2070 0 cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20760 gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20820 tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaat ctca 20880 gtggtacgaa acagaaatta atcatgcagc tgggagagtc ctaaaaaaga ctaccccaat 20940 gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 21000 tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 21060 tgaggcagcc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 21120 tgtagatata ga aaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 21180 ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 21240 ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 21300 cca agcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 21360 ccagcttttg cttgattcca ttggtgatag aaccaggtac atgg atggga aaaagatgct acagaatttt cagataaaaa 21600 tgaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21660 aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21720 caac gtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21780 tcccgggcta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21840 caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21900 gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21960 aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 22020 catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 22080 tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 22140 tgaggccatg cttagaaacg acac caacga ccagtccttt aacgactatc tctccgccgc 22200 caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 22260 caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 22320 actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 22380 aaccttttac ctcaacca cctttaagaa ggtggccatt acctttgact cttctgtcag 22440 ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22500 cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22560 gctagctaac tataacattg gctaccaggg ctt ctatatc ccagagagct acaaggaccg 22620 catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22680 atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22740 ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22800 tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct gac gtggtcc gtgtgcacca 23040 gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 23100 cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 23160 gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac 23220 aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacgg cc 23280 ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 23340 tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 23400 gagtacgagt cactcctgcg ccgtagcg cc attgcttctt cccccgaccg ctgtataacg 23460 ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23520 tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23580 atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23640 ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23700 agccacagtg cgcaga ttag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23760 taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23820 ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcg ca 23880 tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23940 tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 24000 accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 24060 tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 24120 t c gtgcccggt ctgggcgtta 24300 ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 24360 tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 24420 tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24480 ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24540 acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24600 tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24660 ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca g gaatcgccc catcatcgtc 24720 acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24780 gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24840 agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24900 cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24960 ctgggctctt cctcttcct c ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 25020 agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 25080 aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacct ct 25140 ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 25200 gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 25260 tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 25320 gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tggggacgt 25380 cgcgccgcac cgcgtccgcg ctcgggggt g gtttcgcgct gctcctcttc ccgactggcc 25440 atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25500 accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25560 t tccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25620 tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25680 c cttgcctac 25860 gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25920 cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25980 cacatctttt tccaaaactg caaga taccc ctatcctgcc gtgccaaccg cagccgagcg 26040 gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 26100 gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 26160 caggaaaaca gcgaaaatga aagtcactct ggaggtgttgg tggaactcga gggtgacaac 26220 gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta ccc ggcactt 26280 aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 26340 cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 26400 gacgagcagc tagcgcgctg gcttcaaacg c gcgagcctg ccgacttgga ggagcgacgc 26460 aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26520 gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26580 tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26640 ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 2670 0 gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26760 gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26820 ctaaagcaaa acttgaagga cctatggacg gccttcaacg ag cgctccgt ggccgcgcac 26880 ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26940 ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 27000 ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 27060 cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 27120 tct gacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 27180 ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 27240 atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 27300 aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 27360 cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccta atgc ggagcttacc 27420 gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27480 caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27540 ctcaacccaa tccccccgcc gccgca gccc tatcagcagc agccgcgggc ccttgcttcc 27600 caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27660 ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27720 ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27780 ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcat ggctac 27840 aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27900 caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27960 acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccata gttg cttgcttgca 28020 agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 28080 cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 28140 cagcggcagc aacagcagcg gccacacaga agcaaaggcg accggatagc aagactctga 28200 caaagcccaa gaaatccaca gcggcggcag cagcaggagg aggagcgctg cgtctggcgc 28260 ccaacga acc cgtatcgacc cgcgagctta gaaacaggat ttttcccact ctgtatgcta 28320 tatttcaaca gagcaggggc caagaacaag agctgaaaat aaaaaacagg tctctgcgat 28380 ccctcaccg cagctgcctg tatcacaaaa gcgaagatca gcttcggcgc ac gctggaag 28440 acgcggaggc tctcttcagt aaatactgcg cgctgactct taaggactag tttcgcgccc 28500 tttctcaaat ttaagcgcga aaactacgtc atctccagcg gccacacccg gcgccagcac 28560 ctgttgtcag cgccattatg agcaaggaaa ttcccacgcc ctacatgtgg agttaccagc 28620 cacaaatggg acttgcggct ggagctgccc aagactactc aacccgaata aactacatga 28680 gcgcgggacc ccacatgata tcccgggtca acggaatacg cgcccaccga aaccgaattc 28740 tcctggaaca ggcggctatt accaccacac ctcgtaataa ccttaatccc cgtagttggc 28800 ccgctgccct ggtgtaccag gaaagtcccg ctcccaccac tgtggtactt cccagagacg 28860 cccaggccga agttcagatg actaactcag gggcgcagct tgcgggcggc tttcgtcaca 28920 gggtgcggtc gcccgggcag ggtataactc acctgacaat cagagggcga ggtattcagc 28980 tcaacgacga gtcggtgagc tcctcgcttg gtctccgtcc ggacgggaca tttcagatcg 29040 gcggcgccgg ccgctcttca ttcacgcctc gtcaggcaat cctaactctg cagacctcgt 29100 cctctgag gg agaggcag 29280 agcaactgcg cctgaaacac ctggtccact gtcgccgcca caagtgcttt gcccgcgact 29340 ccggtgagtt ttgctacttt gaattgcccg aggatcatat cgagggcccg gcgcacggcg 29400 tccggcttac cgcccaggga gagcttgccc gtagcctgat tcgggagttt acccagcgcc 29460 ccctgctagt tgagcgggac aggggaccct gtgttctcac tgtgatttgc aactgtccta 29520 accctggatt acatcaagat cctctagtta at gtcaggtc gcctaagtcg attaactaga 29580 gtacccgggg atcttattcc ctttaactaa taaaaaaaa taataaagca tcacttactt 29640 aaaatcagtt agcaaatttc tgtccagttt attcagcagc acctccttgc cctcctccca 29700 gctctggtat tg cagcttcc tcctggctgc aaactttctc cacaatctaa atggaatgtc 29760 agtttcctcc tgttcctgtc catccgcacc cactatcttc atgttgttgc agatgaagcg 29820 cgcaagaccg tctgaagata ccttcaaccc cgtgtatcca tatgacacgg aaaccggtcc 29880 tccaactgg ccttttctta ctcctccctt tgtatccccc aatgggtttc aagagagtcc 29940 ccctggggta ctctctttgc gcctatccga acctctagtt acc tccaatg gcatgcttgc 30000 gctcaaaatg ggcaacggcc tctctctgga cgaggccggc aaccttacct cccaaaatgt 30060 aaccactgg agcccacctc tcaaaaaaac caagtcaaac ataaacctgg aaatatctgc 30120 acccctcaca gttacctcag a agccctaac tgtggctgcc gccgcacctc taatggtcgc 30180 gggcaacaca ctcaccatgc aatcacaggc cccgctaacc gtgcacgact ccaaacttag 30240 cattgccacc caaggacccc tcacagtgtc agaaggaaag ctagccctgc aaacatcagg 30300 ccccctcacc accaccgata gcagtaccct tactatcact gcctcacccc ctctaactac 30360 tgccactggt agcttgggca ttgacttgaa agagcccatt tatacacaa atggaa aact 30420 aggactaaag tacggggctc ctttgcatgt aacagacgac ctaaacactt tgaccgtagc 30480 aactggtcca ggtgtgacta ttaataatac ttccttgcaa actaaagtta ctggagcctt 30540 gggttttgat tcacaaggca atatgcaact taatgtagca g gaggactaa ggattgattc 30600 tcaaaacaga cgccttatac ttgatgttag ttatccgttt gatgctcaaa accaactaaa 30660 tctaagacta ggacagggcc ctctttttat aaactcagcc cacaacttgg atattaacta 30720 caacaaaggc ctttacttgt ttacagcttc aaacaattcc aaaaagcttg aggttaacct 30780 aagcactgcc aaggggttga tgtttgacgc tacagccata gccattaatg caggagatgg 3084 0 gcttgaattt ggttcaccta atgcaccaaa cacaaatccc ctcaaaacaa aaattggcca 30900 tggcctagaa tttgattcaa acaaggctat ggttcctaaa ctaggaactg gccttagttt 30960 tgacagcaca ggtgccatta cagtaggaaa caaaaataat gataagc taa ctttgtggac 31020 cggaataaac cctccaccta actgtcaaat tgtggaaaac actaatacaa atgatggcaa 31080 acttacttta gatttagtaa aaaatggagg gcttgttaat ggctacgtgt ctctagttgg 31140 tgtatcagac actgtgaacc aaatgttcac aaaaagaca gcaaacatcc aattaagatt 31200 atattttgac tcttctggaa atctattaac tgaggaatca gacttaaaaa ttccacttaa 31260 aa ataaatct tctacagcga ccagtgaaac tgtagccagc agcaaagcct ttatgccaag 31320 tactacagct tatcccttca acaccactac tagggatagt gaaaactaca ttcatggaat 31380 atgttactac atgactagtt atgatagaag tctatttccc ttgaacattt ctataatgct 31 440 aaacagccgt atgatttctt ccaatgttgc ctatgccata caatttgaat ggaatctaaa 31500 tgcaagtgaa tctccagaaa gcaacatagc tacgctgacc acatccccct ttttcttttc 31560 ttacattaca gaagacgaca actaaagaat cgtttgtgtt atgtttcaac gtgtttattt 31620 ttcaattgca gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata 31680 gcttatacag atcaccgtac cttaatcaaa ctcacagaac cctagtattc aacctgccac 31740 ctccctccca acacacagag tacacagtcc tttctccccg gctggcctta aaaagcatca 31800 tatcatgggt aacagacata ttcttaggtg ttatattcca cacggtttcc tgtcgagcca 31860 aacgctcatc agtg atatta ataaactccc cgggcagctc acttaagttc atgtcgctgt 31920 ccagctgctg agccacaggc tgctgtccaa cttgcggttg at tcgcaccg cccgcagcat aaggcgcctt gtcctccggg 32160 cacagcagcg caccctgatc tcacttaaat cagcacagta actgcagcac agcaccacaa 32220 tattgttcaa aatcccacag tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag 32 280 aacccacgtg gccatcatac cacaagcgca ggtagattaa gtggcgaccc ctcataaaca 32340 cgctggacat aaacattacc tcttttggca tgttgtaatt caccacctcc cggtaccata 32400 taaacctctg attaaacatg gcgccatcca ccaccatcct aaaccagctg gccaaaacct 32460 gcccgccggc tatacactgc agggaaccgg gactggaaca atgacagtgg agagcccagg 32520 actcgtaacc atggatcatc atgctcgtca tgatatcaat gttggcacaa cacaggcaca 32580 cgtgcataca cttcctcagg attacaagct cctcccgcgt tagaaccata tcccagggaa 32640 caacccattc ctgaatcagc gtaaatccca cactgcaggg aagacctcgc acgtaactca 32700 cgttgtgcat tgtcaaagtg ttacattcgg gca gcagcgg atgatcctcc agtatggtag 32760 cgcgggtttc tgtctcaaaa ggaggtagac gatccctact gtacggagtg cgccgagaca cactctct ca aagcatccag gcgccccctg 33000 gcttcgggtt ctatgtaaac tccttcatgc gccgctgccc tgataacatc caccaccgca 33060 gaataagcca cacccagcca acctacacat tcgttctgcg agtcacacac gggaggagcg 33120 ggaagagctg gaagaaccat gttttttttt ttattccaaa agattatcca aaacctcaaa 33180 atgaagatct attaagtgaa cgcgctcccc tccggtggcg tggtcaaact ctacagccaa 33240 agaacagata atggcatttg taagatgttg cacaatggct tccaaaaggc aaacggccct 33300 cacgtccaag tggacgtaaa ggctaaaccc ttcagggtga atctcctcta taaacattcc 33360 agcaccttca accatgccca aataattctc atctcgccac cttctcaata tatctcta ag 33420 caaatcccga atattaagtc cggccattgt aaaaatctgc tccagagcgc cctccacctt 33480 cagcctcaag cagcgaatca tgattgcaaa aattcaggtt cctcacagac ctgtataaga 33540 ttcaaaagcg gaacattaac aaaaataccg cgatcccg ta ggtcccttcg cagggccagc 33600 tgaacataat cgtgcaggtc tgcacggacc agcgcggcca cttccccgcc aggaaccatg 33660 acaaaagaac ccacactgat tatgacacgc atactcggag ctatgctaac cagcgtagcc 33720 ccgatgtaag cttgttgcat gggcggcgat ataaaatgca aggtgctgct caaaaaatca 33780 ggcaaagcct cgcgcaaaaa agaaagcaca tcgtagtcat gctcatgcag at aaaggcag 33840 gtaagctccg gaaccaccac agaaaaagac accatttttc tctcaaacat gtctgcgggt 33900 ttctgcataa acacaaaata aaataacaaa aaaacattta aacattagaa gcctgtctta 33960 caacaggaaa aacaaccctt ataagcataa gacggactac gg ccatgccg gcgtgaccgt 34020 aaaaaaactg gtcaccgtga ttaaaaagca ccaccgacag ctcctcggtc atgtccggag 34080 tcataatgta agactcggta aacacatcag gttgattcac atcggtcagt gctaaaaagc 34140 gaccgaaata gcccggggga atacataccc gcaggcgtag agacaacatt acagccccca 34200 taggaggtat aacaaaatta ataggagaga aaaacacata aacacctgaa aaaccctcct 34260 gcctaggcaa aatagcac cc tcccgctcca gaacaacata cagcgcttcc acagcggcag 34320 ccataacagt cagccttacc agtaaaaaag aaaacctatt aaaaaaacac cactcgacac 34380 ggcaccagct caatcagtca cagtgtaaaa aagggccaag tgcagagcga gtaatatag 34440 gact aaaaaa tgacgtaacg gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa 34500 cctacgccca gaaacgaaag ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt 34560 tcccacgtta cgtcacttcc cattttaaga aaactacaat tcccaacaca tacaagttac 34620 tccgccctaa aacctacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc 34680caccccctca ttatcat att ggcttcaatc caaaataagg tatattattg atgatg 34736 <210> 28 <211> 37705 <212> DNA <213> artificial sequence <220> <223> plasmid #4 vector <400> 28 ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60 aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120 ggctgcggcg agcggtatca gctcactcaa aggcggta at acggttatcc acagaatcag 180 gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240 aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300 gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360 ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420 cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480 cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540 gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600 cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660 agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720 ctctgctgaa gccagttacc ttcgga aaaa gagttggtag ctcttgatcc ggcaaacaaa 780 ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840 gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900 cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960 attaaaaatg aagttttaaa tcaatctaaa gtatata tga gtaaacttgg tctgacagtt 1020 accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080 ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140 gtgctgcaat gataccgcga gacccac gct caccggctcc agatttatca gcaataaacc 1200 agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260 ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320 ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380 cgtagaaagc cagtccgcag aaacggtgct gaccccgg at gaatgtcagc tactgggcta 1440 tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500 ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560 cgccctctgg taaggttggg aagccctg ca aagtaaactg gatggctttc ttgccgccaa 1620 ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680 tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740 gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800 cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860 aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920 tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980 atctcctgtc atctcacctt gctcctgccg aga aagtatc catcatggct gatgcaatgc 2040 ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100 tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160 agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220 gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280 gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340 tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400 tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgcctt ctat cgccttcttg 2460 acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520 gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580 gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640 aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700 gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760 tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820 gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgc gctt 2880 aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940 atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000 tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060 atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120 tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180 aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240 gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 33 00 cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360 gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420 ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480 ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540 atgacggtaa atggcccgcc tggcattatg ccc agtacat gaccttatgg gactttccta 3600 cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660 acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg 3720 acgtcaatgg gagtttgttt tggca ccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780 actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc t gtgttcctg gtgctgctgc 4020 cactggtgtc cagccagtgt gtgaacctga ccaccaggac ccaacttcct cctgcctaca 4080 ccaactcctt caccagggga gtctactacc ctgacaaggt gttcaggtcc tctgtgctgc 4140 acagcaccca ggacctgttc ctgccattct tcagcaatgt gacctggttc catgccatcc 4200 atgtgtctgg caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg 4260 gagtctactt tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca 4320 ccctggacag caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta 4380 aggtgtgtga gttccagttc tgtaatgacc cattcctggg agtctactac cacaagaaca 4440 acaagtcctg gatggagtct gagttcaggg tctactcctc tgccaacaac tgtacctttg 4500 aatatgtgag ccaaccattc ctgatggact tggagggcaa gcagggcaac ttcaagaacc 4560 tgagggagtt tgtgttcaag aacattgatg gctactt caa gatttacagc aaacacacac 4620 caatcaacct ggtgagggac ctgccacagg gcttctctgc cttggaacca ctggtggacc 4680 tgccaattgg catcaacatc accaggttcc agaccctgct ggctctgcac aggtcctacc 4740 tgacacctgg agactcctcc tctggctgga cagcaggagc agcagcctac tatgtgggct 4800 acctccaacc aaggaccttc ctgctgaaat acaatgagaa tggcaccatc acagatg ctg 4860 tggactgtgc cctggaccca ctgtctgaga ccaagtgtac cctgaaatcc ttcacagtgg 4920 agaagggcat ctaccagacc agcaacttca gggtccaacc aacagagagc attgtgaggt 4980 ttccaaacat caccaacctg tgtccatttg gagaggtgtt caatgcca cc aggtttgcct 5040 ctgtctatgc ctggaacagg aagaggatta gcaactgtgt ggctgactac tctgtgctct 5100 acaactctgc ctccttcagc accttcaagt gttatggagt gagcccaacc aaactgaatg 5160 acctgtgttt caccaatgtc tatgctgact cctttgtgat taggggat gaggtgagac 5220 agattgcccc tggacaaaca ggcaagattg ctgactacaa ctacaaactg cctgatgact 5280 t cacaggctg tgtgattgcc tggaacagca acaacctgga cagcaaggtg ggaggcaact 5340 acaactacct ctacagactg ttcaggaaga gcaacctgaa accatttgag agggacatca 5400 gcacagagat ttaccaggct ggcagcacac catgtaatgg agtggagggc ttcaactgtt 5460 act ttccact ccaatcctat ggcttccaac caaccaatgg agtgggctac caaccataca 5520 gggtggtggt gctgtccttt gaactgctcc atgcccctgc cacagtgtgt ggaccaaaga 5580 agagcaccaa cctggtgaag aacaagtgg tgaacttcaa cttcaatgga ctgacaggca 5640 caggagtgct gacagagagc aacaagaagt tcctgccatt ccaacagttt ggcagggaca 5700 ttgctgac ac cacagatgct gtgagggacc cacagacctt ggagattctg gacatcacac 5760 catgttcctt tggaggagtg tctgtgatta cacctggcac caacaccagc aaccaggtgg 5820 ctgtgctcta ccaggatgtg aactgtactg aggtgcctgt ggctatccat gctgaccaac 5880 ttaca ccaac ctggagggtc tacagcacag gcagcaatgt gttccagacc agggctggct 5940 gtctgattgg agcagagcat gtgaacaact cctatgagtg tgacatccca attggagcag 6000 gcatctgtgc ctcctaccag acccagaccg gtggcggtgg gtcgggcggt ggtgggtcgg 6060 gtggcggcgg ttccaggtct gtggcaagcc agagcatcat tgcctacaca atgagtctgg 6120 gagcagagaa ctctgtggct ta cagcaaca acagcattgc catcccaacc aacttcacca 6180 tctctgtgac cacagagatt ctgcctgtga gtatgaccaa gacctctgg gactgtacaa 6240 tgtatatctg tggagacagc acagagtgta gcaacctgct gctccaatat ggctccttct 6300 gtacccaact taacagggct ct gacaggca ttgctgtgga acaggacaag aacacccagg 6360 aggtgtttgc ccaggtgaag cagatttaca agacacctcc aatcaaggac tttggaggct 6420 tcaacttcag ccagattctg cctgacccaa gcaagccaag caagaggtcc ttcattgagg 6480 acctgctgtt caacaaggtg accctggctg atgctggctt catcaagcaa tatggagact 6540 gtctgggaga cattgctgcc agggacctga ttt gtgccca gaagttcaat ggactgacag 6600 tgctgcctcc actgctgaca gatgagatga ttgcccaata cacctctgcc ctgctggctg 6660 gcaccatcac ctctggctgg acctttggag caggagcagc cctccaaatc ccatttgcta 6720 tgcagatggc ttacaggt tc aatggcattg gagtgaccca gaatgtgctc tatgagaacc 6780 agaaactgat tgccaaccag ttcaactctg ccattggcaa gattcaggac tccctgtcca 6840 gcacagcctc tgccctgggc aaactccaag atgtggtgaa ccagaatgcc caggctctga 6900 acaccctggt gaagcaactt tccagcaact ttggagccat ctcctctgtg ctgaatgaca 6960 tcctgagcag actggacaag gtggaggctg aggtcc agat tgacagactg attacaggca 7020 gactccaatc cctccaaacc tatgtgaccc aacaacttat cagggctgct gagattaggg 7080 catctgccaa cctggctgcc accaagatga gtgagtgtgt gctgggacaa agcaagaggg 7140 tggacttctg tggcaagggc taccacctga tgagtt ttcc acagtctgcc cctcatggag 7200 tggtgttcct gcatgtgacc tatgtgcctg cccaggagaa gaacttcacc acagcccctg 7260 ccatctgcca tgatggcaag gctcactttc caagggaggg agtgtttgg agcaatggca 7320 cccactggtt tgtgacccag aggaacttct atgaaccaca gattatcacc acagacaaca 7380 cctttgtgtc tggcaactgt gatgtggtga ttggcattgt gaacaacaca gtctat gacc 7440 cactccaacc tgaactggac tccttcaagg aggaactgga caaatacttc aagaaccaca 7500 ccagccctga tgtggacctg ggagacatct ctggcatcaa tgcctctgtg gtgaacatcc 7560 agaaggat tgacagactg aatgaggtgg ctaagaacct gaatgagtcc ctgattgacc 7620 tccaagaact gggcaaatat gaacaataca tcaagtggcc atgaaaattg atcataatca 7680 gccataccac atttgtagag gttttaacttg ctttaaaaaa cctcccacac ctccccctga 7740 acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 7800 gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcat t 7860 ctagttgtgg tttgtccaaa ctcatcaatg tatcttaacg cggatctggg cgtggttaag 7920 ggtgggaaag aatatataag gtgggggtct tatgtagttt tgtatctgtt ttgcagcagc 7980 cgccgccgcc atgagcacca actcgtttga tggaagcatt gt gagctcat atttgacaac 8040 gcgcatgccc ccatgggccg gggtgcgtca gaatgtgatg ggctccagca ttgatggtcg 8100 ccccgtcctg cccgcaaact ctactacctt gacctacgag accgtgtctg gaacgccgtt 8160 ggagactgca gcctccgccg ccgcttcagc cgctgcagcc accgcccgcg ggattgtgac 8220 tgactttgct ttcctgagcc cgcttgcaag cagtgcagct tcccgttcat ccgcc cgcga 8280 tgacaagttg acggctcttt tggcacaatt ggattctttg acccgggaac ttaatgtcgt 8340 ttctcagcag ctgttggatc tgcgccagca ggtttctgcc ctgaaggctt cctcccctcc 8400 caatgcggtt taaaaaaacc agactctgtt tggatttgga tcaagcaagt 8460 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 8520 gtcgttgagg gtcctgtgta tttttccag gacgtggtaa aggtgactct ggatgttcag 8580 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 8640 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 8 700 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 8760 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 8820 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcaga a ccaccagcac 8880 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 8940 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 9000 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 9060 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 9120 cggtataatg gt tccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 9180 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 9240 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 9300 gccggtgggc ccgtaaatca cacctattac cggctgcaac tggtagttaa gagagctgca 9360 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 9420 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 9480 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 9540 aagcagttcc aggc ggtccc acagctcggt cacctgctct acggcatctc gatccagcat 9600 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 9660 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 9 720 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 9780 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 9840 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 9900 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 9960 gattccgggg agtaggcatc cgcgccgca g gccccgcaga cggtctcgca ttccacgagc 10020 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 10080 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 10 140 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 10200 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 10260 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 10320 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 10380 ggtgttcctg aaggggggct ataaaagggg gtggggg cgc gttcgtcctc actctcttcc 10440 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 10500 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 10560 gcggtgatgc ctt tgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 10620 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 10680 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 10740 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 10800 acgcgccaac cgcggttgtg cagg gtgaca aggtcaacgc tggtggctac ctctccgcgt 10860 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 10920 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 10 980 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 11040 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 11100 gaggcgtaca gctctgctc g gaagactatc 11280 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 11340 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 11400 accagctcgg cggtgacctg cacgtctag g gcgcagtagt ccagggtttc cttgatgatg 11460 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 11520 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 11580 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 11640 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 1 1700 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 11760 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 11820 cccgcgcgag gcataaagtt gcgtgtgatg cggaaggg tc ccggcacctc ggaacggttg 11880 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgg gcccacaatg 11940 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 12000 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 12060 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 12120 aaggt cctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 12180 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 12240 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 12300 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 12360 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 12420 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 12480 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 12540 cgcacaagga agcaga gtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 12600 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 12660 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagct tgatg 12720 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 12780 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 12840 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 12900 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 12960 gcatctaaaa gcggtgacgc gggc gagccc ccggaggtag ggggggctcc ggacccgccg 13020 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 13080 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctct gcgtga 13140 agacgacggg cccggtgagc ttgaacctga aagagagttc gacagaatca atttcggtgt 13200 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 13260 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 13320 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 13380 cctcgttcca gacgcggctg tagaccacg c ccccttcggc atcgcgggcg cgcatgacca 13440 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 13500 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 13560 gcaacgt gga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 13620 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 13680 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 13740 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 13800 ggggaggggg gacacggcgg cgacgacggc gcaccggggg gcggtcgaca aagcgctcga 13860 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 13920 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 13980 gcagggatac gg cgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 14040 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 14100 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 14160 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 14220 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatg cgcagg cggtcggcca 14280 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 14340 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 14400 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 14460 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 14520 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 14580 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 14640 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 14700 aagtccgcac caggtactgg tatccaccca aaaagtgcgg cggcggctgg cggtagaggg 14760 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 14820 cgtagatgta cctggacatc caggtgatgc cggcggcggt gg tggaggcg cgcggaaagt 14880 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 14940 ggccggtcag gcgcgcgcaa tcgttgacgc tctagcgtgc aaaaggag cctgtaagcg 15000 ggcactcttc cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt 15060 tcgagccccg tatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc 15120 caggtgtgcg acgtcagaca acgggggagt gctccttttg gcttccttcc aggcgcggcg 15180 gctgctgcgc tagctttttt ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa 15240 gcgaaagcat taagtggctc gctccctgta gccggagggt tatt ttccaa gggttgagtc 15300 gcgggacccc cggttcgagt ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc 15360 ccgtcatgca agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc 15420 ttttcccaga tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag 15480 caagagcagc ggcagacatg cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg 15540 acatccgcgg ttgacgcggc agcagatggt gattacgaac ccccgcggcg ccgggcccgg 15600 cactacctgg acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag 15660 cggcacccaa gggtgcagct gaagcgtgat acgcgtgagg cgtacgtgcc gcggcaga ac 15720 ctgtttcgcg accgcgaggg agaggagccc gaggagatgc gggatcgaaa gttccacgca 15780 gggcgcgagc tgcggcatgg cctgaatcgc gagcggttgc tgcgcgagga ggactttgag 15840 cccgacgcgc gaaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta 15900 accgcatacg agcagacggt gaaccaggag attaactttc aaaaaagctt taacaaccac 15960 gtgcgtacgc ttgtggcgc g cgaggaggtg gctataggac tgatgcatct gtgggacttt 16020 gtaagcgcgc tggagcaaaa cccaaatagc aagccgctca tggcgcagct gttccttata 16080 gtgcagcaca gcagggacaa cgaggcattc agggatgcgc tgctaaacat agtagagccc 16140 gagggccgct ggctgctcga tttgataaac atcctgcaga gcatagtggt gcaggagcgc 16200 agcttgagcc tggctgacaa ggtggccgcc atcaactatt ccatgcttag cctgggcaag 16260 ttttacgccc gcaagatata ccatacccct tacgttccca tagacaagga ggtaaagatc 16320 gaggggttct acatgcgcat ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt 16380 tatcgcaacg agcgcatcca caaggccgtg agcgtgag cc ggcggcgcga gctcagcgac 16440 cgcgagctga tgcacagcct gcaaagggcc ctggctggca cgggcagcgg cgatagagag 16500 gccgagtcct actttgacgc gggcgctgac ctgcgctggg ccccaagccg acgcgccctg 16560 gaggcagctg ggg ccggacc tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc 16620 ggcgtggagg aatatgacga ggacgatgag tacgagccag aggacggcga gtactaagcg 16680 gtgatgtttc tgatcagatg atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc 16740 agagccagcc gtccggcctt aactccacgg acgactggcg ccaggtcatg gaccgcatca 16800 tgtcgctgac tgcgcgcaat cctgacgcgt tccggcag ca gccgcaggcc aaccggctct 16860 ccgcaattct ggaagcggtg gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg 16920 cgatcgtaaa cgcgctggcc gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct 16980 acgacgcgct gcttca gcgc gtggctcgtt acaacagcgg caacgtgcag accaacctgg 17040 accggctggt gggggatgtg cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg 17100 gcaacctggg ctccatggtt gcactaaacg ccttcctgag tacacagccc gccaacgtgc 17160 cgcggggaca ggaggactac accaactttg tgagcgcact gcggctaatg gtgactgaga 17220 caccgcaaag tgaggtgtac cagtctgggc cagactattt tttccagacc agtagacaag 17280 gcctgcagac cgtaaacctg agccaggctt tcaaaaactt gcaggggctg tggggggtgc 17340 gggctcccac aggcgaccgc gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt 17400 tgctgctgct aatagcgccc ttcacggaca gtggcagcgt gtcccgggac acatacctag 17460 gtcacttgct gacactgtac cgcgaggcca taggtcaggc gcatgtggac gagcatactt 17520 tccaggagat tacaagtgtc agccgcgcgc tggggcagga ggacacgggc agcctggagg 17580 caaccctaaa ctacctgctg accaaccggc ggcagaagat cccctcgttg cacagtttaa 17640 acagcgagga ggagcgcatt ttgcgctacg tgcagcagag cgtgagcctt aacctgat gc 17700 gcgacggggt aacgcccagc gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca 17760 tgtatgcctc aaaccggccg tttatcaacc gcctaatgga ctacttgcat cgcgcggccg 17820 ccgtgaaccc cgagtatttc accaatgcca t cttgaaccc gcactggcta ccgccccctg 17880 gtttctacac cgggggattc gaggtgcccg agggtaacga tggattcctc tgggacgaca 17940 tagacgacag cgtgttttcc ccgcaaccgc ccag cactcg caccacccgc ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc 18180 tgctgcagcc gcagcgcgaa aaaaacctgc ctccggcatt tcccaacaac gggatagaga 18240 gcctagtgga caagatgagt agatggaaga cgtacgcgca ggagcaca gg gacgtgccag 18300 gcccgcgccc gcccacccgt cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg 18360 acgatgactc ggcagacgac agcagcgtcc tggatttggg agggagtggc aacccgtttg 18420 cgcaccttcg ccccaggctg gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata 18480 aaaaactcac caaggccatg gcaccgagcg ttggttttct tgtattcccc ttagtatgcg 18540 gcgcgcgg cg atgtatgagg aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc 18600 gccagtggcg gcggcgctgg gttctccctt cgatgctccc ctggacccgc cgtttgtgcc 18660 tccgcggtac ctgcggccta ccggggggag aaacagcatc cgttactctg agt tggcacc 18720 cctattcgac accacccgtg tgtacctggt ggacaacaag tcaacggatg tggcatccct 18780 gaactaccag aacgaccaca gcaactttct gaccacggtc attcaaaaca atgactacag 18840 cccgggggag gcaagcacac agaccatcaa tcttgacgac cggtcgcact ggggcggcga 18900 cctgaaaacc atcctgcata ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa 18960 gtttaaggcg cgggtgatgg tgtcgcgctt g cctactaag gacaatcagg tggagctgaa 19020 atacgagtgg gtggagttca cgctgcccga gggcaactac tccgagacca tgaccataga 19080 ccttatgaac aacgcgatcg tggagcacta cttgaaagtg ggcagacaga acggggttct 19140 ggaaagcgac atcgg ggtaa agtttgacac ccgcaacttc agactggggt ttgaccccgt 19200 cactggtctt gtcatgcctg gggtatatac aaacgaagcc ttccatccag acatcatttt 19260 gctgccagga tgcggggtgg acttcaccca cagccgcctg agcaacttgt tgggcatccg 19320 caagcggcaa cccttccagg agggctttag gatcacctac gatgatctgg agggtggtaa 19380 cattcccgca ctgttggatg tggacgccta ccaggcgagc ttgaaagatg acaccgaaca 19440 gggcgggggt ggcgcaggcg gcagcaacag cagtggcagc ggcgcggaag agaactccaa 19500 cgcggcagcc gcggcaatgc agccggtgga ggacatgaac gatcatgcca ttcgcggcga 19560 cacctttgcc acacgg gctg aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc 19620 cgcccccgct gcgcaacccg aggtcgagaa gcctcagaag aaaccggtga tcaaacccct 19680 gacagaggac agcaagaaac gcagttacaa cctaataagc aatgacagca ccttcaccca 19740 gtaccgcagc tggtaccttg catacaacta cggcgaccct cagaccggaa tccgctcatg 19800 gaccctgctt tgcactcctg acgtaacctg cggctcggag caggtctact ggtc gttgcc 19860 agacatgatg caagaccccg tgaccttccg ctccacgcgc cagatcagca actttccggt 19920 ggtgggcgcc gagctgttgc ccgtgcactc caagagcttc tacaacgacc aggccgtcta 19980 ctcccaactc atccgccagt ttacctctct gaccc acgtg ttcaatcgct ttcccgagaa 20040 ccagattttg gcgcgcccgc cagcccccac catcaccacc gtcagtgaaa acgttcctgc 20100 tctcacagat cacgggacgc taccgctgcg caacagcatc ggaggagtcc agcgagtgac 20160 cattactgac gccagacgcc gcacctgccc ctacgtttac aaggccctgg gcatagtctc 20220 gccgcgcgtc ctatcgagcc gcactttttg agcaagcatg tccatcctta tatcgcccag 20280 caataacaca ggctggggcc tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg 20340 ctccgaccaa cacccagtgc gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa 20400 acgcggccgc actgggcgca ccaccgtcga t gacgccatc gacgcggtgg tggaggaggc 20460 gcgcaactac acgcccacgc cgccaccagt gtccacagtg gacgcggcca ttcagaccgt 20520 ggtgcgcgga gcccggcgct atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg 20580 ccaccgccgc cgacccggca ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc 20640 acgtcgcacc ggccgacggg cggccatgcg ggccgctcga aggctggccg cgggtattgt 2 0700 cactgtgccc cccaggtcca ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc 20760 tatgactcag ggtcgcaggg gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg 20820 cgtgcccgtg cgcacccgcc ccccgcgcaa ctag attgca agaaaaaact acttagactc 20880 gtactgttgt atgtatccag cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat 20940 caaagaagag atgctccagg tcatcgcgcc ggagatctat ggccccccga agaaggaaga 21000 gcaggattac aagccccgaa agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga 21060 tgaacttgac gacgaggtgg aactgctgca cgctaccgcg cccaggcgac gggtacagtg 21120 gaaaggtcga at aaggacat 21300 gctggcgttg ccgctggacg agggcaaccc aacacctagc ctaaagcccg taacactgca 21360 gcaggtgctg cccgcgcttg caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg 21420 tgacttggca cccaccgtgc agctgatggt acccaagcgc cagcgactgg aagatgtctt 21480 ggaaaaaatg accgtggaac ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca 21540 ggtggcgccg ggact gggcg tgcagaccgt ggacgttcag atacccacta ccagtagcac 21600 cagtattgcc accgccacag agggcatgga gacacaaacg tccccggttg cctcagcggt 21660 ggcggatgcc gcggtgcagg cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca 21 720 aacggacccg tggatgtttc gcgtttcagc cccccggcgc ccgcgccgtt cgaggaagta 21780 cggcgccgcc agcgcgctac tgcccgaata tgccctacat ccttccattg cgcctacccc 21840 cggctatcgt ggctaccct accgccccag aagacgagca actacccgac gccgaaccac 21900 cactggaacc cgccgccgcc gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg 21960 cagggtggct cgcgaaggag gcaggaccct gg tgctgcca acagcgcgct accaccccag 22020 catcgtttaa aagccggtct ttgtggttct tgcagatatg gccctcacct gccgcctccg 22080 tttcccggtg ccgggattcc gaggaagaat gcaccgtagg aggggcatgg ccggccacgg 22140 cctgacgggc ggcat gcgtc gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat 22200 gcgcggcggt atcctgcccc tccttattcc actgatcgcc gcggcgattg gcgccgtgcc 22260 cggaattgca tccgtggcct tgcaggcgca gagacactga ttaaaaacaa gttgcatgg 22320 gaaaaatcaa aataaaaagt ctggactctc acgctcgctt ggtcctgtaa ctattttgta 22380 gaatggaaga catcaacttt gcgtctctgg cc ccg cgaca cggctcgcgc ccgttcatgg 22440 gaaactggca agatatcggc accagcaata tgagcggtgg cgccttcagc tggggctcgc 22500 tgtggagcgg cattaaaaat ttcggttcca ccgttaagaa ctatggcagc aaggcctgga 22560 acagcagc ac aggccagatg ctgagggata agttgaaaga gcaaaatttc caacaaaagg 22620 tggtagatgg cctggcctct ggcattagcg gggtggtgga cctggccaac caggcagtgc 22680 aaaataagat taacagtaag cttgatcccc gccctcccgt agaggagcct ccaccggccg 22740 tggagacagt gtctccagag gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa 22800 ctctggtgac gcaaatagac gagcctccct cgtacgagga ggcactaaag caa ggcctgc 22860 ccaccacccg tcccatcgcg cccatggcta ccggagtgct gggccagcac acacccgtaa 22920 cgctggacct gcctcccccc gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg 22980 ccgttgttgt aacccgtcct agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat 23040 cgttgcggcc cgtagccagt ggcaactggc aaagcacact gaacagcatc gtgggtctgg 23100 gggtgcaatc cctgaagcgc cgacgatgct tctgatagct aacgtgtcgt atgtgtgtca 23160 tgtatgcgtc catgtcgccg ccagaggagc tgctgagccg ccgcgcgccc gctttccaag 23220 atggctaccc cttcgatgat gccgcagtgg tcttacatgc acatctcggg ccagg gttcat ccct gtggaccgtg aggatactgc gtactcgtac 23460 aaggcgcggt tcaccctagc tgtgggtgat aaccgtgtgc tggacatggc ttccacgtac 23520 tttgacatcc gcggcgtgct ggacaggggc cctactttta agccctactc tggcactgcc 23580 tacaacgccc tggctcccaa gggtgcccca aatccttgcg aatgggatga agctgctact 23640 gctcttgaaa taaacctaga agaagaggac gatgacaacg aagacgaagt agacgagcaa 23700 gctgag cagc aaaaaactca cgtatttggg caggcgcctt attctggtat aaatattaca 23760 aaggagggta ttcaaatagg tgtcgaaggt caaacaccta aatatgccga taaaacattt 23820 caacctgaac ctcaaatagg agaatctcag tggtacgaaa cagaaattaa tcatgcag ct 23880 gggagagtcc taaaaaagac taccccaatg aaaccatgtt acggttcata tgcaaaaccc 23940 acaaatgaaa atggagggca aggcattctt gtaaagcaac aaaatggaaa gctagaaagt 24000 caagtggaaa tgcaattttt ctcaactact gaggcagccg caggcaatgg tgataacttg 24060 actcctaaag tggtattgta cagtgaagat gtagatatag aaacccaga cactcatatt 24120 tcttacatgc ccactatt aa ggaaggtaac tcacgagaac taatgggcca acaatctatg 24180 cccaacaggc ctaattacat tgcttttagg gacaatttta ttggtctaat gtattacaac 24240 agcacgggta atatgggtgt tctggcgggc caagcatcgc agttgaatgc tgttgtagat 24300 t tgcaagaca gaaacacaga gctttcatac cagcttttgc ttgattccat tggtgataga 24360 accaggtact tttctatgtg gaatcaggct gttgacagct atgatccaga tgttagaatt 24420 attgaaaatc atggaactga agatgaactt ccaaattact gctttccact gggaggtgtg 24480 attaatacag agactcttac caaggtaaaa cctaaaacag gtcaggaaaa tggatgggaa 24540 aaagatgcta cagaattttc agata aaaat gaaataagag ttggaaataa ttttgccatg 24600 gaaatcaatc taaatgccaa cctgtggaga aatttcctgt actccaacat agcgctgtat 24660 ttgcccgaca agctaaagta cagtccttcc aacgtaaaaa tttctgataa cccaacc 24 720 tacgactaca tgaacaagcg agtggtggct cccgggctag tggactgcta cattaacctt 24780 ggagcacgct ggtcccttga ctatatggac aacgtcaacc catttaacca ccaccgcaat 24840 gctggcctgc gctaccgctc aatgttgctg ggcaatggtc gctatgtgcc cttccacatc 24900 caggtgcctc agaagttctt tgccattaaa aacctccttc tcctgccggg ctcatacacc 24960 tacgagtgga acttcaggaa gg atgttaac atggttctgc agagctccct aggaaatgac 25020 ctaagggttg acggagccag cattaagttt gatagcattt gcctttacgc caccttcttc 25080 cccatggccc acaacaccgc ctccacgctt gaggccatgc ttagaaacga caccaacgac 25140 cagtcct tta acgactatct ctccgccgcc aacatgctct accctatacc cgccaacgct 25200 accaacgtgc ccatatccat cccctcccgc aactgggcgg ctttccgcgg ctgggccttc 25260 acgcgcctta agactaagga aaccccatca ctgggctcgg gctacgaccc ttattacacc 25320 tactctggct ctatacccta cctagatgga accttttacc tcaaccacac ctttaagaag 25380 gtggccatta cctttgactc ttctgtcagc tggcctggca atgaccgcct gcttaccccc 25440 aacgagtttg aaattaagcg ctcagttgac ggggagggtt acaacgttgc ccagtgtaac 25500 atgaccaaag actggttcct ggtacaaatg ctagctaact ataacattgg ctaccagggc 25560 ttctatatcc cagagagcta caaggaccgc atgtactcc t tctttagaaa cttccagccc 25620 atgagccgtc aggtggtgga tgatactaaa tacaaggact accaacaggt gggcatccta 25680 caccaacaca acaactctgg atttgttggc taccttgccc ccaccatgcg cgaaggacag 25740 gcctaccctg ctaacttccc ctatccgctt ataggcaaga ccgcagttga cagcattacc 25800 cagaaaaagt ttctttgcga tcgcaccctt tggcgcatcc cattctccag ta actttatg 25860 tccatgggcg cactcacaga cctgggccaa aaccttctct acgccaactc cgcccacgcg 25920 ctagacatga cttttgaggt ggatcccatg gacgagccca cccttcttta tgttttgttt 25980 gaagtctttg acgtggtccg tgtgcaccag ccgcaccgcg gcgtcatcga aaccgtgtac 26040 ctgcgcacgc ccttctcggc cggcaacgcc acaacataaa gaagcaagca acatcaacaa 26100 cagctgccgc catgggctcc agtgagcagg aactgaaagc cattgtcaaa gatcttggtt 26160 gtgggccata ttttttgggc acctatgaca agcgctttcc aggctttgtt tctccacaca 26220 agctcgcctg cgccatagtc aatacggccg gtcgcgagac tgggggcgta cact ggatgg 26280 cctttgcctg gaacccgcac tcaaaaacat gctacctctt tgagcccttt ggcttttctg 26340 accagcgact caagcaggtt taccagtttg agtacgagtc actcctgcgc cgtagcgcca 26400 ttgcttcttc ccccgaccgc t gtataacgc tggaaaagtc cacccaaagc gtacaggggc 26460 ccaactcggc cgcctgtgga ctattctgct gcatgtttct ccacgccttt gccaactggc 26520 cccaaactcc catggatcac aaccccacca tgaaccttat taccggggta cccaactcca 26580 tgctcaacag tccccaggta cagcccaccc tgcgtcgcaa ccaggaacag ctctacagct 26640 tcctggagcg ccactcgccc tacttccgca gccacagtgc gcagattagg agcgccactt 2670 0 ctttttgtca cttgaaaaac atgtaaaaat aatgtactag agacactttc aataaaggca 26760 aatgctttta tttgtacact ctcgggtgat tatttacccc cacccttgcc gtctgcgccg 26820 tttaaaaatc aaaggggttc tgccgcgcat cgctatgc gc cactggcagg gacacgttgc 26880 gatactggtg tttagtgctc cacttaaact caggcacaac catccgcggc agctcggtga 26940 agttttcact ccacaggctg cgcaccatca ccaacgcgtt tagcaggtcg ggcgccgata 27000 tcttgaagtc gcagttgggg cctccgccct gcgcgcgcga gttgcgatac acagggttgc 27060 agcactggaa cactatcagc gccgggtggt gcacgctggc cagcacgctc ttgtcggaga 27120 tcagatccgc gtccaggtcc tccgcgttgc tcagggcgaa cggagtcaac tttggtagct 27180 gccttcccaa aaagggcgcg tgcccaggct ttgagttgca ctcgcaccgt agtggcatca 27240 aaaggtgacc gtgcccggtc tgggcgttag gatacagcgc ctgcataaaa gccttgatct 27300 gcttaaaagc cacctgagcc tttgcgcctt cagagaagaa catgccgcaa gacttgccgg 27360 aaaactgatt ggccggacag gccgcgtcgt gcacgcagca cct tgcgtcg gtgttggaga 27420 tctgcaccac atttcggccc caccggttct tcacgatctt ggccttgcta gactgctcct 27480 tcagcgcgcg ctgcccgttt tcgctcgtca catccatttc aatcacgtgc tccttattta 27540 tcataatgct tccgtgtaga cacttaagct cgccttcgat ctcagcgcag cggtgcagcc 27600 acaacgcgca gcccgtgggc tcgtgatgct tgtaggtcac ctctgcaaac gactgcaggt 27660 acgcctgcag gaatcgcccc atcatcgtca caaaggtctt gttgctggtg aaggtcagct 27720 gcaacccgcg gtgctcctcg ttcagccagg tcttgcatac ggccgccaga gcttccactt 27780 ggtcaggcag tagtttgaag ttcgccttta gatcgttatc cacgtggtac ttgtccatca 27840 gcgcgcgcgc agcctccatg cccttctccc acgcagacac gatcggcaca ctcagcgggt 27900 tcatcaccgt aatttcactt tccgcttcgc tgggctcttc ctcttcctct tgcgtccgca 27960 taccacgcgc cactgggtc g tcttcattca gccgccgcac tgtgcgctta cctcctttgc 28020 catgcttgat tagcaccggt gggttgctga aacccaccat ttgtagcgcc acatcttctc 28080 tttcttcctc gctgtccacg attacctctg gtgatggcgg gcgctcgggc ttgggagaag 28140 ggcgcttctt tttcttcttg ggcgcaatgg ccaaatccgc cgccgaggtc gatggccgcg 28200 ggctgggtgt gcgcggcacc agcgcgtctt gtgatgagtc ttcctcgtcc tcggactcga 28260 tacgccgcct catccgcttt tttgggggcg cccggggagg cggcggcgac ggggacgggg 28320 acgacacgtc ctccatggtt gggggacgtc gcgccgcacc gcgtccgcgc tcgggggtgg 28380 tttcgcgctg ctcctcttcc cgactggcca tttccttctc ctataggcag aaaaagatca 28440 tggagtcagt cgagaagaag gacagcctaa ccgccccctc tgagttcgcc accaccgcct 28500 ccaccgatgc cgccaacgcg cctaccacct tccccgtcga ggcacccccg cttgaggagg 28560 aggaagtgat tatcgagcag gacccaggtt ttgtaagcga agacgacgag gaccgctcag 28620 taccaacaga ggataaaaag caagaccagg acaacgcaga ggcaaacgag gaacaagtcg 28680 gg cgggggga cgaaaggcat ggcgactacc tagatgtggg agacgacgtg ctgttgaagc 28740 atctgcagcg ccagtgcgcc attatctgcg acgcgttgca agagcgcagc gatgtgcccc 28800 tcgccatagc ggatgtcagc cttgcctacg aacgccacct attct caccg cgcgtacccc 28860 ccaaacgcca agaaaacggc acatgcgagc ccaacccgcg cctcaacttc taccccgtat 28920 ttgccgtgcc agaggtgctt gccacctatc acatcttttt ccaaaactgc aagatacccc 28980 tatcctgccg tgccaaccgc agccgagcgg acaagcagct ggccttgcgg cagggcgctg 29040 tcatacctga tatcgcctcg ctcaacgaag tgccaaaaat ctttgagggt cttggacgcg 29100 acgagaag cg cgcggcaaac gctctgcaac aggaaaacag cgaaaatgaa agtcactctg 29160 gagtgttggt ggaactcgag ggtgacaacg cgcgcctagc cgtactaaaa cgcagcatcg 29220 aggtcaccca ctttgcctac ccggcactta acctaccccc caaggtcatg agcaca gtca 29280 tgagtgagct gatcgtgcgc cgtgcgcagc ccctggagag ggatgcaaat ttgcaagaac 29340 aaacagagga gggcctaccc gcagttggcg acgagcagct agcgcgctgg cttcaaacgc 29400 gcgagcctgc cgacttggag gagcgacgca aactaatgat ggccgcagg ctcgttaccg 29460 tggagcttga gtgcatgcag cggttctttg ctgacccgga gatgcagcgc aagctagagg 29520 aaacattgca ctacccttt cgacagggct acgtacgcca ggcctgcaag atctccaacg 29580 tggagctctg caacctggtc tcctaccttg gaattttgca cgaaaaccgc cttgggcaaa 29640 acgtgcttca ttccacgctc aagggcgagg cgcgccgcga ctacgtccgc gactgcgtt t 29700 acttatttct atgctacacc tggcagacgg ccatgggcgt ttggcagcag tgcttggagg 29760 agtgcaacct caaggagctg cagaaactgc taaagcaaaa cttgaaggac ctatggacgg 29820 ccttcaacga gcgctccgtg gccgcgcacc tggcggacat cattttcccc gaacgcctgc 29880 ttaaaaccct gcaacagggt ctgccagact tcaccagtca aagcatgttg cagaacttta 29940 ggaactttat cctagagcgc tcaggaatct tgcccgccac ctgctgtgca cttcctagcg 30000 actttgtgcc cattaagtac cgcgaatgcc ctccgccgct ttggggccac tgctaccttc 30060 tgcagctagc caactacctt gcctaccact ctgacataat ggaagacgtg agcggtgacg 30120 gtctactgga gtgtcactgt cg ctgcaacc tatgcacccc gcaccgctcc ctggtttgca 30180 attcgcagct gcttaacgaa agtcaaatta tcggtacctt tgagctgcag ggtccctcgc 30240 ctgacgaaaa gtccgcggct ccggggttga aactcactcc ggggctgtgg acgtcggctt 30300 accttcgcaa atttgtacct gaggactacc acgcccacga gattaggttc tacgaagacc 30360 aatcccgccc gcctaatgcg gagcttaccg cctgcgtcat tacccagggc cac attcttg 30420 gccaattgca agccatcaac aaagcccgcc aagagtttct gctacgaaag ggacgggggg 30480 tttacttgga cccccagtcc ggcgaggagc tcaacccaat ccccccgccg ccgcagccct 30540 atcagcagca gccgcgggcc cttgcttccc agg atggcac ccaaaaagaa gctgcagctg 30600 ccgccgccac ccacggacga ggaggaatac tgggacagtc aggcagagga ggttttggac 30660 gaggaggagg aggacatgat ggaagactgg gagagcctag acgaggaagc ttccgaggtc 30720 gaagaggtgt cagacgaaac accgtcaccc tcggtcgcat tcccctcgcc ggcgccccag 30780 aaatcggcaa ccggttccag catggctaca acctccgctc ctcaggcgcc gccggcactg 30 840 cccgttcgcc gacccaaccg tagatgggac accactggaa ccagggccgg taagtccaag 30900 cagccgccgc cgttagccca agagcaacaa cagcgccaag gctaccgctc atggcgcggg 30960 cacaagaacg ccatagttgc ttgcttgcaa gactgtgggg gcacatctc ct tcgcccgc 31020 cgctttcttc tctaccatca cggcgtggcc ttcccccgta acatcctgca ttactaccgt 31080 catctctaca gcccatactg caccggcggc agcggcagca acagcagcgg ccacacagaa 31140 gcaaaggcga ccggatagca agactctgac aaagcccaag aaatccacag cggcggcagc 31200 agcaggagga ggagcgctgc gtctggcgcc caacgaaccc gtatcgaccc gcgagcttag 31260 ctcttcagta aatactgcgc 31440 gctgactctt aaggactagt ttcgcgccct ttctcaaatt taagcgcgaa aactacgtca 31500 tctccagcgg ccacacccgg cgccagcacc tgttgtcagc gccattatga gcaaggaaat 31560 tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg gagctgccca 31620 agactactca acccgaataa actacatgag cgcgggaccc cacatgatat cccgggtcaa 31680 cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta ccaccacacc 31740 tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc 31800 tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga ctaactcagg 31860 ggcgcagct t gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg gtataactca 31920 cctgacaatc agagggcgag gtattcagct caacgacgag at tgaggagt ttgtgccatc ggtctacttt aaccccttct cgggacctcc 32160 cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact cggcggacgg 32220 ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc tggtccactg 32 280 tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg aattgcccga 32340 ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag agcttgcccg 32400 tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca gggggaccctg 32460 tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc ctctagttaa 32520 tgtcaggtcg cctaagtcga ttaactagag tacccg ggga tcttattccc tttaactaat 32580 aaaaaaaat aataaagcat cacttactta aaatcagtta gcaaatttct gtccagttta 32640 ttcagcagca cctccttgcc ctcctcccag ctctggtatt gcagcttcct cctggctgca 32700 aactttctcc acaatctaa a tggaatgtca gtttcctcct gttcctgtcc atccgcaccc 32760 actatcttca tgttgttgca gatgaagcgc gcaagaccgt ctgaagatac cttcaacccc 32820 gtgtatccat atgacacgga aaccggtcct ccaactgtgc ctttcttac tcctcccttt 32880 gtatccccca atgggtttca agagagtccc cctggggtac tctctttgcg cctatccgaa 32940 cctctagtta cctccaatgg catgcttgcg ctcaaaat gg gcaacggcct ctctctggac 33000 gaggccggca accttacctc ccaaaatgta accactgtga gcccacctct caaaaaaacc 33060 aagtcaaaca taaacctgga aatatctgca cccctcacag ttacctcaga agccctaact 33120 gtggctgccg ccgcacctct aatggtc gcg ggcaacacac tcaccatgca atcacaggcc 33180 ccgctaaccg tgcacgactc caaacttagc attgccaccc aaggacccct cacagtgtca 33240 gaaggaaagc tagccctgca aacatcaggc cccctcacca ccaccgatag cagtaccctt 33300 actatcactg cctcaccccc tctaactact gccactggta gcttgggcat tgacttgaaa 33360 gagcccattt atacacaaaa tggaaaacta ggactaaagt acggggctcc tttgcatg ta 33420 acagacgacc taaacacttt gaccgtagca actggtccag gtgtgactat taataatact 33480 tccttgcaaa ctaaagttac tggagccttg ggttttgatt cacaaggcaa tatgcaactt 33540 aatgtagcag gaggactaag gattgattct caaaacagac gccttatact tgatgttagt 33600 tatccgtttg atgctcaaaa ccaactaaat ctaagactag gacagggccc tctttttata 33660 aactcagccc acaacttgga tattaactac aacaaaggcc tttaacttgtt tacagcttca 33720 aacaattcca aaaagcttga ggttaaccta agcactgcca aggggttgat gtttgacgct 33780 acagccatag ccattaatgc aggagatggg cttgaatttg gttcacctaa tgcaccaaac 3 3840 acaaatcccc tcaaaacaaa aattggccat ggcctagaat ttgattcaaa caaggctatg 33900 gttcctaaac taggaact gg ccttagtttt gacagcacag gtgccattac agtaggaaac 33960 aaaaataatg ataagctaac tttgtggacc ggaataaacc ctcca cctaa ctgtcaaatt 34020 gtggaaaaca ctaatacaaa tgatggcaaa cttactttag tattagtaaa aaatggaggg 34080 cttgttaatg gctacgtgtc tctagttggt gtatcagaca ctgtgaacca aatgttcaca 34140 caaaagacag caaacatcca attaagatta tattttgact cttctggaaa tctattaact 34200 gaggaatcag acttaaaaat tccacttaaa aataaatctt ctacagcgac cagtgaaact 34260 g tagccagca gcaaagcctt tatgccaagt actacagctt atcccttcaa caccactact 34320 agggatagtg aaaactacat tcatggaata tgttactaca tgactagtta tgatagaagt 34380 ctatttccct tgaacatttc tataatgcta aacagccgta tgatttcttc caatgttgcc 34440 tatgccatac aatttgaatg gaatctaaat gcaagtgaat ctccagaaag caacatagct 34500 acgctgacca catccccctt tttcttttct c tagtattca acctgccacc tccctcccaa cacacagagt acacagtcct 34740 ttctccccgg ctggccttaa aaagcatcat atcatgggta acagacatat tcttaggtgt 34800 tatattccac acggtttcct gtcgagccaa acgctcatca gtgatattaa taaactcccc 34860 gggcagctca cttaag ttca tgtcgctgtc cagctgctga gccacaggct gctgtccaac 34920 ttgcggttgc ttaacgggcg gcgaaggaga agtccacgcc tacatggggg tagagtcata 34980 atcgtgcatc aggatagggc ggtggtgctg cagcagcgcg cgaataaact gctgccgccg 35040 ccgctccgtc ctgcaggaat acaacatggc agtggtctcc tcagcgatga ttcgcaccgc 35100 ccgcagcata aggcgcct tg tcctccgggc acagcagcgc accctgatct cacttaaatc 35160 agcacagtaa ctgcagcaca gcaccacaat attgttcaaa atcccacagt gcaaggcgct 35220 gtatccaaag ctcatggcgg ggaccaga acccacgtgg ccatcatacc acaagcgcag 35280 gtagattaag tggcgacccc tcataaacac gctggacata aacattacct cttttggcat 35340 gttgtaattc accacctccc ggtaccatat aaacctctga ttaaacatgg gtgcatac ac ttcctcagga ttacaagctc 35580 ctcccgcgtt agaaccatat cccagggaac aacccattcc tgaatcagcg taaatcccac 35640 actgcaggga agacctcgca cgtaactcac gttgtgcatt gtcaaagtgt tacattcggg 35700 cagcagcgga tgatcctcc a gtatggtagc gcgggtttct gtctcaaaag gaggtagacg 35760 atccctactg tacggagtgc gccgagacaa ccgagatcgt gttggtcgta gtgtcatgcc 35820 aaatggaacg ccggacgtag tcatatttcc tgaagcaaaa ccaggtgcgg gcgtgacaaa 35880 cagatctgcg tctccggtct cgccgcttag atcgctctgt gtagtagttg tagtatatcc 35940 actctctcaa agcatccagg cgccccctgg cttcgggttc ta tgtaaact ccttcatgcg 36000 ccgctgccct gataacatcc accaccgcag aataagccac acccagccaa cctacacatt 36060 cgttctgcga gtcacacacg ggaggagcgg gaagagctgg aagaaccatg tttttttttt 36120 tattccaaaa gattatccaa aacct caaaa tgaagatcta ttaagtgaac gcgctcccct 36180 ccggtggcgt ggtcaaactc tacagccaaa gaacagataa tggcatttgt aagatgttgc 36240 acaatggctt ccaaaaggca aacggccctc acgtccaagt ggacgtaaag gctaaaccct 36300 tcagggtgaa tctcctctat aaacattcca gcaccttcaa ccatgcccaa ataattctca 36360 tctcgccacc ttctcaatat atctctaagc aaatcccgaa tattaagtcc ggccattgta 36420 aaaatctgct ccagagcgcc ctccaccttc agcctcaagc agcgaatcat gattgcaaaa 36480 attcaggttc ctcacagacc tgtataagat tcaaaagcgg aacattaaca aaaataccgc 36540 gatcccgtag gtcccttcgc agggccagct gaacataatc gtgcaggtct gcacggacca 36600 gcgcggccac ttccccgcca ggaaccatga caaaagaacc cacactgatt atgacacgca 36660 tactcggagc tatgctaacc agcgtagccc cgatgtaagc ttgttgcatg ggcggcgata 36720 taaaatgcaa ggtgctgctc aaaaaatcag gcaaagcctc gcgcaaaaaa gaaagcacat 36780 cgtagtcatg ctcatgcaga taaaggcagg taagctccgg aaccaccaca gaaaaagaca 36840 ccatttttct ctcaaacatg tctgcgggtt tctgcataaa cacaaataa aataacaaaa 36900 aaacatttaa acattagaag cctgtcttac aacaggaaaa acaaccctta taagcataag 36960 acggactacg gccatgccgg cgtgaccgta aaaaaactgg t caccgtgat taaaaagcac 37020 caccgacagc tcctcggtca tgtccggagt cataatgtaa gactcggtaa acacatcagg 37080 ttgattcaca tcggtcagtg ctaaaaagcg accgaaatag cccgggggaa tacatacccg 37140 caggcgtaga gacaacatta cagcccccat aggaggtata acaaaattaa taggagagaa 37200 aaacacataa acacctgaaa aaccctcctg cctaggcaaa atagcaccct cccgctccag 37260 aacaacatac agcgctt cca cagcggcagc cataacagtc agccttacca gtaaaaaaga 37320 aaacctatta aaaaaacacc actcgacacg gcaccagctc aatcagtcac agtgtaaaaa 37380 agggccaagt gcagagcgag tatatatagg actaaaaaat gacgtaacgg ttaaagtcca 37440 caaaaaacac ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc 37500 acaacttcct caaatcgtca cttccgtttt cccacgttac gtcacttccc attttaagaa 37560 aactacaatt cccaacacat acaagttaact ccgccctaaa acctacgtca cccgccccgt 37620 tcccacgccc cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc 37680aaaataaggt atattattga tgatg 37 705 <210> 29 <211> 34766 <212> DNA <213> artificial sequence <220> <223> #4 vector <400> 29 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg t ggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gt gttatca tagcgcgtaa tactgtaata gtaatcaatt 360 acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420 ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt 480 cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540 actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600 aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660 acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720 tacatcaatg ggcgtggata gcggtttgac tcac ggggat ttccaagtct ccaccccatt 780 gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840 aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900 agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960 cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020 agacaccggg accgatccag cctccgattt gccaccatgt ttgtgttcct ggtgctgctg 1080 ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc tcctgcctac 1140 accaactcct tcaccaggggg agtctactac cctgacaagg tgt tcaggtc ctctgtgctg 1200 cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt ccatgccatc 1260 catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc attcaatgat 1320 ggaggtctact ttgccagcac agagaagagc aacatcatca ggggctggat ttttggcacc 1380 accctggaca gcaagaccca gtccctgctg attgtgaaca atgccaccaa tgtggt gatt 1440 aaggtgtgg agttccagtt ctgtaatgac ccattcctgg gagtctacta ccacaagaac 1500 aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa ctgtaccttt 1560 gaatatgtga gccaaccatt cctgatggac ttggagggca agcagg gcaa cttcaagaac 1620 ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag caaacacaca 1680 ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc actggtggac 1740 ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca caggtcctac 1800 ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta ctatgtgg gc 1860 tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat cacagatgct 1920 gtggactgg ccctggaccc actgtctgag accaagtgta ccctgaaatc cttcacagtg 1980 gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag cattgt gagg 2040 tttccaaaca tcaccaacct gtgtccattt ggagaggtgt tcaatgccac caggtttgcc 2100 tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta ctctgtgctc 2160 tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac caaactgaat 2220 gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga tgaggtgaga 22 80 cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact gcctgatgac 2340 ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt gggaggcaac 2400 tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga gagggacatc 2460 agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg cttcaactgt 2520 tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta ccaaccatac 2580 agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgg tggaccaaag 2640 aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg actgacaggc 2700 acaggagtgc tgacagagag caacaagaag tcctgccat tccaacagtt tggcagggac 2760 attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct ggacatcaca 2820 ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag caaccaggtg 2880 gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca tgctgaccaa 2940 cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac cagggctggc 3000 tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc aattggagca 3060 ggcatctgg cctcctacca gacccagacc ggtggcggtg ggtcgggcgg tggtgggtcg 3120 ggtggcggcg gttccaggtc tgtggcaagc cagagcatca ttgcctacac aatgagtctg 3180 ggagcagaga actctgtggc ttacagcaac aacagcattg ccatcccaac caacttcacc 3240 atctctgtga ccacagagat tctgcctgtg agtatgacca agacctctgt ggactgtaca 3300 atgtatatct gtggagacag cacagagtgt agcaacctgc tgctccaata tggctccttc 3360 tgtacccaac ttaacagggc tctgacaggc attgctgtgg aacaggacaa gaacacccag 3420 gaggtgtttg cccaggtgaa gcagatttac aagacacctc caatcaagga ctttggaggc 3480 ttcaacttca gccagattct gcctgaccca agcaagccaa gcaagaggtc cttcattgag 3540 gacctgctgt tcaacaaggt gaccctgg ct gatgctggct tcatcaagca atatggagac 3600 tgtctgggag acattgctgc cagggacctg atttgtgccc agaagttcaa tggactgaca 3660 gtgctgcctc cactgctgac agatgagatg attgcccaat acacctctgc cctgctggct 3720 ggcaccatca cctctggct g gacctttgga gcaggagcag ccctccaaat cccatttgct 3780 atgcagatgg cttacaggtt caatggcatt ggaggtgaccc agaatgtgct ctatgagaac 3840 cagaaactga ttgccaacca gttcaactct gccattggca agattcagga ctccctgtcc 3900 agcacagcct ctgccctggg caaactccaa gatgtggtga accagaatgc ccaggctctg 3960 aacaccctgg tgaagcaact ttccagcaac tttggagcca tctcctctgt gctgaatgac 4020 atcctgagca gactggacaa ggtggaggct gaggtccaga ttgacagact gattacaggc 4080 agactccaat ccctccaaac ctatgtgacc caacaactta tcagggctgc tgagattagg 4140 gcatctgcca acctggctgc caccaagatg agtgagt gtg tgctggggaca aagcaagagg 4200 gtggacttct gtggcaaggg ctaccacctg atgagttttc cacagtctgc ccctcatgga 4260 gtggtgttcc tgcatgtgac ctatgtgcct gcccaggaga agaacttcac cacagcccct 4320 gccatctgcc atgatggcaa ggctcacttt ccaagggagg gagtgtttgt gagcaatggc 4380 acccactggt ttgtgaccca gaggaacttc tatgaaccac agattatcac c acagacaac 4440 acctttgtgt ctggcaactg tgatgtggtg attggcattg tgaacaacac agtctatgac 4500 ccactccaac ctgaactgga ctccttcaag gaggaactgg acaaatactt caagaaccac 4560 accagccctg atgtggacct gggagacatc tctggcatca atgcctctgt ggt gaacatc 4620 cagaaggaga ttgacagact gaatgaggtg gctaagaacc tgaatgagtc cctgattgac 4680 ctccaagaac tgggcaaata tgaacaatac atcaagtggc catgaaaatt gatcataatc 4740 agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 4800 aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 4860 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 4920 tctagttgg gtttgtccaa actcatcaat gtatcttaac gcggatctgg gcgtggttaa 4980 gggtgggaaa gaatatataa ggtgggggtc ttatgtagtt ttgtatct gt tttgcagcag 5040 ccgccgccgc catgagcacc aactcgtttg atggaagcat tgtgagctca tatttgacaa 5100 cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat gggctccagc attgatggtc 5160 gccccgtcct gcccgcaaac tctactacct tgacctacga gaccgtgtct ggaacgccgt 5220 tggagactgc agcctccgcc gccgcttcag ccgctgcagc caccgcccgc gggattgt ga 5280 ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc ttcccgttca tccgcccgcg 5340 atgacaagtt gacggctctt ttggcacaat tggattcttt gacccgggaa cttaatgtcg 5400 tttctcagca gctgttggat ctgcgcc agc aggtttctgc cctgaaggct tcctcccctc 5460 ccaatgcggt ttaaaacata aataaaaaac cagactctgt ttggatttgg atcaagcaag 5520 tgtcttgctg tctttattta ggggttttgc gcgcgcggta ggcccgggac cagcggtctc 5580 ggtcgttgag ggtcctgtgt attttttcca ggacgtggta aaggtgactc tggatgttca 5640 gatacatggg cataagcccg tctctggggt ggaggtagca ccactgcaga gcttcatgct 570 0 gcggggtggt gttgtagatg atccagtcgt agcaggagcg ctgggcgtgg tgcctaaaaa 5760 tgtctttcag tagcaagctg attgccaggg gcaggccctt ggtgtaagtg tttacaaagc 5820 ggttaagctg ggatgggtgc atacgtgggg atatgagatg catcttggac tgtattttta 5880 ggttggctat gttcccagcc atatccctcc ggggattcat gttgtgcaga accaccagca 5940 cagtgtatcc ggtgcacttg ggaaatttgt catgtagctt agaaggaaat gcgtggaaga 6000 acttggagac gcccttgtga cctccaagat tttccatgca ttcgtccata atgatggcaa 6060 tgggcccacg ggcggcggcc tgggcgaaga tatttctggg atcactaacg tcatagttgt 6120 gttccaggat gagatc gtca taggccattt ttacaaagcg cgggcggagg gtgccagact 6180 gcggtataat ggttccatcc ggcccagggg cgtagttacc ctcacagatt tgcatttccc 6240 acgctttgag ttcagatggg gggatcatgt ctacctgcgg ggcgatgaag aaaacggttt 6300 ccggggtagg ggagatcagc tgggaagaaa gcaggttcct gagcagctgc gacttaccgc 6360 agccggtggg cccgtaaatc acacctatta ccggctgcaa ctggtagtta agagagctgc 6420 agctgccgtc atccctgagc aggggggcca cttcgttaag catgtccctg actcgcatgt 6480 tttccctgac caaatccgcc agaaggcgct cgccgcccag cgatagcagt tcttgcaagg 6540 aagcaaagtt tttcaacggt t tgagaccgt ccgccgtagg catgcttttg agcgtttgac 6600 caagcagttc caggcggtcc cacagctcgg tcacctgctc tacggcatct cgatccagca 6660 tatctcctcg tttcgcgggt tggggcggct ttcgctgtac ggcagtagtc ggtgctcgtc 6720 cagacgggcc agggtcatgt ctttccacgg gcgcagggtc ctcgtcagcg tagtctgggt 6780 cacggtgaag gggtgcgctc cgggctgcgc gctggccagg gtgcgcttga ggctggtcct 6840 gctggtgctg aagcgctgcc ggtcttcgcc ctgcgcgtcg gccaggtagc atttgaccat 6900 ggtgtcatag tccagcccct ccgcggcgtg gcccttggcg cgcagcttgc ccttggagga 6960 ggcgccgcac gaggggcagt g cagactttt gagggcgtag agcttgggcg cgagaaatac 7020 cgattccggg gagtaggcat ccgcgccgca ggccccgcag acggtctcgc attccacgag 7080 ccaggtgagc tctggccgtt cggggtcaaa aaccaggttt cccccatgct ttttgatgcg 714 0 tttcttacct ctggtttcca tgagccggtg tccacgctcg gtgacgaaaa ggctgtccgt 7200 gtccccgtat acagacttga gaggcctgtc ctcgagcggt gttccgcggt cctcctcgta 7260 tagaaactcg gaccactctg agacaaaggc tcgcgtccag gccagcacga aggaggctaa 7320 gtgggagggg tagcggtcgt tgtccactag ggggtccact cgctccaggg tgtgaagaca 7380 catgtcgccc tcttcggcat caaggaaggt gattggtttg tagggtgtagg cagtttccaa aaacgaggag gatttgatat tcacctggcc 7620 cgcggtgatg cctttgaggg tggccgcatc catctggtca gaaaagacaa tctttttgtt 7680 gtcaagcttg gtggcaaacg acccgtagag ggcgttggac agcaacttgg cgatggagcg 7740 cagggtttgg tttttgtcgc gatcggcgcg ctccttggcc gcgatgttta gctgcacgta 7800 ttcgcgcgca acgcaccgcc attcgggaaa gacggtgg tg cgctcgtcgg gcaccaggtg 7860 cacgcgccaa ccgcggttgt gcagggtgac aaggtcaacg ctggtggcta cctctccgcg 7920 taggcgctcg ttggtccagc agaggcggcc gcccttgcgc gagcagaatg gcggtagggg 7980 gtctagctgc gtct cgtccg gggggtctgc gtccacggta aagaccccgg gcagcaggcg 8040 cgcgtcgaag tagtctatct tgcatccttg caagtctagc gcctgctgcc atgcgcgggc 8100 ggcaagcgcg cgctcgtatg ggttgagtgg gggaccccat ggcatggggt gggtgagcgc 8160 ggaggcgtac atgccgcaaa tgtcgtaaac gtagaggggc tctctgagta ttccaagata 8220 tgtagggtag catcttccac cgcggatgct ggcgcgcacg taatcgtata gttcgtg cga 8280 gggagcgagg aggtcgggac cgaggttgct acgggcgggc tgctctgctc ggaagactat 8340 ctgcctgaag atggcatgg agttggatga tatggttgga cgctggaaga cgttgaagct 8400 ggcgtctgtg agacctaccg cgtcacgcac gaaggaggcg tagga gtcgc gcagcttgtt 8460 gaccagctcg gcggtgacct gcacgtctag ggcgcagtag tccagggttt ccttgatgat 8520 gtcatactta tcctgtccct tttttttcca cagctcgcgg ttgaggacaa actcttcgcg 8580 gtctttccag tactcttgga tcggaaaccc gtcggcctcc gaacggtaag agcctagcat 8640 gtagaactgg ttgacggcct ggtaggcgca gcatcccttt tctacgggta gcgcgtatgc 8700 ctgcgcggcc ttccggagcg aggtgtgggt gagcgcaaag gtgtccctga ccatgacttt 8760 gaggtactgg tatttgaagt cagtgtcgtc gcatccgccc tgctcccaga gcaaaaagtc 8820 cgtgcgcttt ttggaacgcg gatttggcag ggc gaaggtg acatcgttga agagtatctt 8880 tcccgcgcga ggcataaagt tgcgtgtgat gcggaagggt cccggcacct cggaacggtt 8940 gttaattacc tgggcggcga gcacgatctc gtcaaagccg ttgatgttgt ggcccacaat 9000 gtaaagttcc aagaagcgcg ggatgccctt gatggaaggc aattttttaa gttcctcgta 9060 ggtgagctct tcaggggagc tgagcccgtg ctctgaaagg gcccagtctg caagatgagg 9120 gtt ggaagcg acgaatgagc tccacaggtc acgggccatt agcatttgca ggtggtcgcg 9180 aaaggtccta aactggcgac ctatggccat tttttctggg gtgatgcagt agaaggtaag 9240 cgggtcttgt tcccagcggt cccatccaag gttcgcggct aggtctcg cg cggcagtcac 9300 tagaggctca tctccgccga acttcatgac cagcatgaag ggcacgagct gcttcccaaa 9360 ggcccccatc caagtatagg tctctacatc gtaggtgaca aagagacgct cggtgcgagg 9420 atgcgagccg atcgggaaga actggatctc ccgccaccaa ttggaggagt ggctattgat 9480 gtggtgaaag tagaagtccc tgcgacgggc cgaacactcg tgctggcttt tgtaaaaacg 9540 tgcgcagtac tgg gcggt gcacgggctg tacatcctgc acgaggttga cctgacgacc 9600 gcgcacaagg aagcagagg ggaatttgag cccctcgcct ggcgggtttg gctggtggtc 9660 ttctacttcg gctgcttgtc cttgaccgtc tggctgctcg aggggagtta cggtggatcg 9720 gaccaccacg ccgcgcgagc ccaaagtcca gatgtccgcg cgcggcggtc ggagcttgat 9780 gacaacatcg cgcagatggg agctgtccat ggtctggagc tcccgcggcg tcaggtcagg 9840 cgggagctcc tgcaggttta cctcgcatag acgggtcagg gcgcgggcta gatccaggtg 9900 atacctaatt tccaggggct ggttggtggc ggcgtcgatg gcttgcaaga ggccgcatcc 9960 ccgcggcgcg actacggtac cgcgcggcgg gcggtgggcc gcgggggtgt ccttggatga 10020 tgcatctaaa agcggtgacg cgggcgagcc cccggaggta gggggggctc cggacccgcc 10080 gggagagggg gcaggggcac gtcggcgccg cgcgcgggca ggagctggtg ctgcgcgcgt 10140 agg ttgctgg cgaacgcgac gacgcggcgg ttgatctcct gaatctggcg cctctgcgtg 10200 aagacgacgg gcccggtgag cttgaacctg aaagagagtt cgacagaatc aatttcggtg 10260 tcgttgacgg cggcctggcg caaaatctcc tgcacgtctc ctgagttgtc ttgataggcg 10320 atctcggcca tgaactgctc gatctcttcc tcctggagat ctccgcgtcc ggctcgctcc 10380 acggtggcgg cgaggtcgtt ggaaatgc gg gccatgagct gcgagaaggc gttgaggcct 10440 ccctcgttcc agacgcggct gtagaccacg cccccttcgg catcgcgggc gcgcatgacc 10500 acctgcgcga gattgagctc cacgtgccgg gcgaagacgg cgtagtttcg caggcgctga 10560 aagaggtag t tgagggtggt ggcggtgtgt tctgccacga agaagtacat aacccagcgt 10620 cgcaacgtgg attcgttgat atcccccaag gcctcaaggc gctccatggc ctcgtagaag 10680 tccacggcga agttgaaaaa ctgggagttg cgcgccgaca cggttaactc ctcctccaga 10740 agacggatga gctcggcgac agtgtcgcgc acctcgcgct caaaggctac aggggcctct 10800 tcttcttctt caatctcctc ttccataagg gcctcccctt cttcttcttc tggcggcggt 10860 gggggagggg ggacacggcg gcgacgacgg cgcaccggga ggcggtcgac aaagcgctcg 10920 atcatctccc cgcggcgacg gcgcatggtc tcggtgacgg cgcggccgtt ctcgcggggg 10980 cgcagt tgga agacgccgcc cgtcatgtcc cggttatggg ttggcggggg gctgccatgc 11040 ggcagggata cggcgctaac gatgcatctc aacaattgtt gtgtaggtac tccgccgccg 11100 agggacctga gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa ggcgtctaac 11160 cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg gcagcgggcg gcggtcgggg 11220 ttgtttctgg cggaggtgct gctgatgatg taattaaagt aggcggt ctt gagacggcgg 11280 atggtcgaca gaagcaccat gtccttgggt ccggcctgct gaatgcgcag gcggtcggcc 11340 atgccccagg cttcgttttg acatcggcgc aggtctttgt agtagtcttg catgagcctt 11400 tctaccggca cttcttctt c tccttcctct tgtcctgcat ctcttgcatc tatcgctgcg 11460 gcggcggcgg agtttggccg taggtggcgc cctcttcctc ccatgcgtgt gaccccgaag 11520 cccctcatcg gctgaagcag ggctaggtcg gcgacaacgc gctcggctaa tatggcctgc 11580 tgcacctgcg tgagggtaga ctggaagtca tccatgtcca caaagcggtg gtatgcgccc 11640 gtgttgatgg tgtaagtgca gttggccata acggaccagt taacggtctg gtgaccc ggc 11700 tgcgagagct cggtgtacct gagacgcgag taagccctcg agtcaaatac gtagtcgttg 11760 caagtccgca ccaggtactg gtatcccacc aaaaagtgcg gcggcggctg gcggtagagg 11820 ggccagcgta gggtggccgg ggctccgggg gcg agatctt ccaacataag gcgatgatat 11880 ccgtagatgt acctggacat ccaggtgatg ccggcggcgg tggtggaggc gcgcggaaag 11940 tcgcggacgc ggttccagat gttgcgcagc ggcaaaaagt gctccatggt cgggacgctc 12000 tggccggtca ggcgcgcgca atcgttgacg ctctagcgtg caaaaggaga gcctgtaagc 12060 gggcactctt ccgtggtctg gtggataaat tcgcaagggt atcatggcgg acgaccgggg 12120 t tcgagcccc gtatccggcc gtccgccgtg atccatgcgg ttaccgcccg cgtgtcgaac 12180 ccaggtgtgc gacgtcagac aacgggggag tgctcctttt ggcttccttc caggcgcggc 12240 ggctgctgcg ctagcttttt tggccactgg ccgcgcgca g cgtaagcggt taggctggaa 12300 agcgaaagca ttaagtggct cgctccctgt agccggaggg ttattttcca agggttgagt 12360 cgcgggaccc ccggttcgag tctcggaccg gccggactgc ggcgaacggg ggtttgcctc 12420 cccgtcatgc aagaccccgc ttgcaaattc ctccggaaac agggacgagc cccttttttg 12480 cttttcccag atgcatccgg tgctgcggca gatgcgcccc cctcctcagc agcggcaaga 12540 gcaagag cag cggcagacat gcagggcacc ctcccctcct cctaccgcgt caggaggggc 12600 gacatccgcg gttgacgcgg cagcagatgg tgattacgaa cccccgcggc gccgggcccg 12660 gcactacctg gacttggagg agggcgaggg cctggcgcgg ctaggagcgc cctct cctga 12720 gcggcaccca agggtgcagc tgaagcgtga tacgcgtgag gcgtacgtgc cgcggcagaa 12780 cctgtttcgc gaccgcgagg gagaggagcc cgaggagatg cgggatcgaa agttccacgc 12840 agggcgcgag ctgcggcatg gcctgaatcg cgagcggttg ctgcgcgagg aggactttga 12900 gcccgacgcg cgaaccggga ttagtcccgc gcgcgcacac gtggcggccg ccgacctggt 12960 aaccgcatac gagcag acgg tgaaccagga gattaacttt caaaaaagct ttaacaacca 13020 cgtgcgtacg cttgtggcgc gcgaggaggt ggctatagga ctgatgcatc tgtgggactt 13080 tgtaagcgcg ctggagcaaa acccaaatag caagccgctc atggcgcagc tgttccttat 13140 agtgcagcac agcagggaca acgaggcatt cagggatgcg ctgctaaaca tagtagagcc 13200 cgagggccgc tggctgctcg atttgataaa catcctgcag agcatagtgg tgcaggagcg 13260 cagcttgagc ctggctgaca aggtggccgc catcaactat tccatgctta gcctgggcaa 13320 gttttacgcc cgcaagatat accatacccc ttacgttccc atagacaagg aggtaaagat 13380 cgaggggttc tacatgcgca tggcgctgaa ggtgcttacc tt gagcgacg acctgggcgt 13440 ttatcgcaac gagcgcatcc acaaggccgt gagcgtgagc cggcggcgcg agctcagcga 13500 ccgcgagctg atgcacagcc tgcaaagggc cctggctggc acgggcagcg gcgatagaga 13560 ggccgagtcc tactttg acg cgggcgctga cctgcgctgg gccccaagcc gacgcgccct 13620 ggaggcagct ggggccggac ctgggctggc ggtggcaccc gcgcgcgctg gcaacgtcgg 13680 gccaggtcat ggaccgcatc 13860 atgtcgctga ctgcgcgcaa tcctgacgcg ttccggcagc agccgcaggc caaccggctc 13920 tccgcaattc tggaagcggt ggtcccggcg cgcgcaaacc ccacgcacga gaaggtgctg 13980 gcgatcgtaa acgcgctggc cgaaaacagg gccatccggc ccgacgaggc cggcctggtc 14040 tacgacgcgc tgcttcagcg cgtggctcgt tacaacagcg gcaacgtgca gaccaacctg 14100 gaccggctgg tgggggatgt gcgcgaggcc gtggcgcagc gtgagcgcgc gcagcagcag 14160 ggcaacctgg gctccatggt tgcactaaac gccttcctga gtacacagcc cgccaacgtg 14220 ccgcggggac aggaggacta caccaacttt gtgagcgcac tgcgg ctaat ggtgactgag 14280 acaccgcaaa gtgaggtgta ccagtctggg ccagactatt ttttccagac cagtagacaa 14340 ggcctgcaga ccgtaaacct gagccaggct ttcaaaaact tgcaggggct gtggggggtg 14400 cgggctccca caggcgaccg cg cgaccgtg tctagcttgc tgacgcccaa ctcgcgcctg 14460 ttgctgctgc taatagcgcc cttcacggac agtggcagcg tgccccggga cacataccta 14520 ggtcacttgc tgacactgta a ggagcgcat tttgcgctac gtgcagcaga gcgtgagcct taacctgatg 14760 cgcgacgggg taacgcccag cgtggcgctg gacatgaccg cgcgcaacat ggaaccgggc 14820 atgtatgcct caaaccggcc gtttatcaac cgcctaatgg actacttgca tcgcgc ggcc 14880 gccgtgaacc ccgagtattt caccaatgcc atcttgaacc cgcactggct accgccccct 14940 ggtttctaca ccgggggatt cgaggtgccc gagggtaacg atggattcct ctgggacgac 15000 atagacgaca gcgtgttttc cccgcaaccg cagaccctgc tagagttgca acagcgcgag 15060 caggcagagg cggcgctgcg aaaggaaagc ttccgcaggc caagcagctt gtccgatcta 15120 ggcg ctgcgg ccccgcggtc agatgctagt agcccatttc caagcttgat agggtctctt 15180 accagcactc gcaccacccg cccgcgcctg ctgggcgagg aggagtacct aaacaactcg 15240 ctgctgcagc cgcagcgcga aaaaaacctg cctccggcat ttccca acaa cgggatagag 15300 agcctagtgg acaagatgag tagatggaag acgtacgcgc aggagcacag ggacgtgcca 15360 ggcccgcgcc cgcccacccg tcgtcaaagg cacgaccgtc agcggggtct ggtgtggggag 15420 gacgatgact cggcagacga cagcagcgtc ctggatttgg gagggagtgg caacccgttt 15480 gcgcaccttc gccccaggct ggggagaatg ttttaaaaaa aaaaaagcat gatgcaaaat 15540 aaaaaactca cca aggccat ggcaccgagc gttggttttc ttgtattccc cttagtatgc 15600 ggcgcgcggc gatgtatgag gaaggtcctc ctccctccta cgagagtgg gtgagcgcgg 15660 cgccagtggc ggcggcgctg ggttctccct tcgatgctcc cctggaccc g ccgtttgtgc 15720 ctccgcggta cctgcggcct accgggggga gaaacagcat ccgttactct gagttggcac 15780 ccctattcga caccacccgt gtgtacctgg tggacaacaa gtcaacggat gtggcatccc 15840 tgaactacca gaacgaccac agcaactttc tgaccacggt cattcaaaac aatgactaca 15900 gcccggggga ggcaagcaca cagaccatca atcttgacga ccggtcgcac tggggcggcg 15960 acctgaaaac catcctgcat accaacatgc caaatgt gaa cgagttcatg tttaccaata 16020 agtttaaggc gcgggtgatg gtgtcgcgct tgcctactaa ggacaatcag gtggagctga 16080 aatacgagtg ggtggagttc acgctgcccg agggcaacta ctccgagacc atgaccatag 16140 accttatgaa caacgcgat c gtggagcact acttgaaagt gggcagacag aacggggttc 16200 tggaaagcga catcggggta aagtttgaca cccgcaactt cagactgggg tttgaccccg cga tgatctg gagggtggta 16440 acattcccgc actgttggat gtggacgcct accaggcgag cttgaaagat gacaccgaac 16500 agggcggggg tggcgcaggc ggcagcaaca gcagtggcag cggcgcggaa gagaactcca 16560 acgcggcagc cgcggcaatg cagccgg tgg aggacatgaa cgatcatgcc attcgcggcg 16620 acacctttgc cacacgggct gaggagaagc gcgctgaggc cgaagcagcg gccgaagctg 16680 ccgcccccgc tgcgcaaccc gaggtcgaga agcctcagaa gaaaccggtg atcaaacccc 16740 tgacagagga cagcaagaaa cgcagttaca acctaataag caatgacagc accttcaccc 16800 agtaccgcag ctggtacctt gcatacaact acggcgaccc tcagaccg ga atccgctcat 16860 ggaccctgct ttgcactcct gacgtaacct gcggctcgga gcaggtctac tggtcgttgc 16920 cagacatgat gcaagacccc gtgaccttcc gctccacgcg ccagatcagc aactttccgg 16980 tggtgggcgc cgagctgttg cccgtg cact ccaagagctt ctacaacgac caggccgtct 17040 actcccaact catccgccag tttacctctc tgacccacgt gttcaatcgc tttcccgaga 17100 accagatttt ggcgcgcccg ccagccccca ccatcaccac cgtcagtgaa aacgttcctg 17160 ctctcacaga tcacgggacg ctaccgctgc gcaacagcat cggaggagtc cagcgagtga 17220 ccattactga cgccagacgc cgcacctgcc cctacgttta caaggccctg ggcatagtct 17 280 cgccgcgcgt cctatcgagc cgcacttttt gagcaagcat gtccatcctt atatcgccca 17340 gcaataacac aggctggggc ctgcgcttcc caagcaagat gtttggcggg gccaagaagc 17400 gctccgacca acacccagtg cgcgtgcgcg ggcactaccg cgcgccctgg ggcgcgcaca 17460 aacgcggccg cactgggcgc accaccgtcg atgacgccat cgacgcggtg gtggaggagg 17520 cgcgcaacta cacgcccacg ccgccaccag tgtccacagt ggacgcggcc attcagaccg 17580 tggtgcgcgg agcccggcgc tatgctaaaa tgaagagacg gcggaggcgc gtagcacgtc 17640 gccaccgccg ccgacccggc actgccgccc aacgcgcggc ggcggccctg cttaa ccgcg 17700 cacgtcgcac cggccgacgg gcggccatgc gggccgctcg aaggctggcc gcgggtattg 17760 tcactgtgcc ccccaggtcc aggcgacgag cggccgccgc agcagccgcg gccattagtg 17820 ctatgactca gggtcgcagg ggcaacgtgt att gggtgcg cgactcggtt agcggcctgc 17880 gcgtgcccgt gcgcacccgc cccccgcgca actagattgc aagaaaaaac tacttagact 17940 cgtactgttg tatgtatcca gcggcggcgg cgcgcaacga agctatgtcc aagcgcaaaa 18000 tcaaagaaga gatgctccag gtcatcgcgc cggagatcta tggccccccg aagaaggaag 18060 agcaggatta caagccccga aagctaaagc gggtcaaaaa gaaaaagaaa gatgatgatg 18120 atgaact tga cgacgaggtg gaactgctgc acgctaccgc gcccaggcga cgggtacagt 18180 ggaaaggtcg acgcgtaaaa cgtgttttgc gacccggcac caccgtagtc tttacgcccg 18240 gtgagcgctc cacccgcacc tacaagcgcg tgtatgatga ggtgtac ggc gacgaggacc 18300 tgcttgagca ggccaacgag cgcctcgggg agtttgccta cggaaagcgg cataaggaca 18360 tgctggcgtt gccgctggac gagggcaacc caacacctag cctaaagccc gtaacactgc 18420 agcaggtgct gcccgcgctt gcaccgtccg aagaaaagcg cggcctaaag cgcgagtctg 18480 gtgacttggc acccaccgtg cagctgatgg tacccaagcg ccagcgactg gaagatgtct 18540 tggaaaaaat gaccgt ggaa cctgggctgg agcccgaggt ccgcgtgcgg ccaatcaagc 18600 aggtggcgcc gggactgggc gtgcagaccg tggacgttca gatacccact accagtagca 18660 ccagtattgc caccgccaca gagggcatgg agacacaaac gtccccggtt gcctcagcgg 18720 t ggcggatgc cgcggtgcag gcggtcgctg cggccgcgtc caagacctct acggaggtgc 18780 aaacggaccc gtggatgttt cgcgtttcag ccccccggcg cccgcgccgt tcgaggaagt 18840 acggcgccgc cagcgcgcta ctgcccgaat atgccctaca tccttccatt gcgcctaccc 18900 ccggctatcg tggctacacc taccgcccca gaagacgagc aactacccga cgccgaacca 18960 ccactggaac ccgccgccgc cgtcg ccgtc gccagcccgt gctggccccg atttccgtgc 19020 gcagggtggc tcgcgaagga ggcaggaccc tggtgctgcc aacagcgcgc taccacccca 19080 gcatcgttta aaagccggtc tttgtggttc ttgcagatat ggccctcacc tgccgcctcc 1914 0 gtttcccggt gccgggattc cgaggaagaa tgcaccgtag gaggggcatg gccggccacg 19200 gcctgacggg cggcatgcgt cgtgcgcacc accggcggcg gcgcgcgtcg caccgtcgca 19260 tgcgcggcgg tatcctgccc ctccttattc cactgatcgc cgcggcgatt ggcgccgtgc 19320 ccggaattgc atccgtggcc ttgcaggcgc agagacactg attaaaaaca agttgcatgt 19380 ggaaaaatca aaataaaaag tctggactct cacgctcgct tggtcctgta actattttgt 19440 agaatggaag acatcaactt tgcgtctctg gccccgcgac acggctcgcg cccgttcatg 19500 ggaaactggc aagatatcgg caccagcaat atgagcggtg gcgccttcag ctggggctcg 19560 ctgtggagc g gcattaaaaa tttcggttcc accgttaaga actatggcag caaggcctgg 19620 aacagcagca caggccagat gctgagggat aagttgaaag agcaaaattt ccaacaaaag 19680 gtggtagatg gcctggcctc tggcattagc ggggtggtgg acctggccaa ccaggcagtg 19740 caaaataaga ttaacagtaa gcttgatccc cgccctcccg tagaggagcc tccaccggcc 19800 gtggagacag tgtctccaga ggggcgtggc gaaaagcgtc cgcgccccga cagggaagaa 19860 actctggtga cgcaaataga cgagcctccc tcgtacgagg aggcactaaa gcaaggcctg 19920 cccaccaccc gtcccatcgc gcccatggct accggagtgc tgggccagca cacacccgta 19980 acgctggacc tgcctccccc cgccgacacc cagca gaaac ctgtgctgcc aggcccgacc 20040 gccgttgttg taacccgtcc tagccgcgcg tccctgcgcc gcgccgccag cggtccgcga 20100 tcgttgcggc ccgtagccag tggcaactgg caaagcacac tgaacagcat cgtgggtctg 20160 ggggtgcaat ccctgaagcg ccgacgatgc ttctgatagc taacgtgtcg tatgtgtgtc 20220 atgtatgcgt ccatgtcgcc gccagaggag ctgctgagcc gccgcgcgcc cgctttcc aa 20280 gatggctacc ccttcgatga tgccgcagtg gtcttacatg cacatctcgg gccaggacgc 20340 ctcggagtac ctgagccccg ggctggtgca gtttgcccgc gccaccgaga cgtacttcag 20400 cctgaataac aagtttagaa accccacggt ggcgcc tacg cacgacgtga ccacagaccg 20460 gtcccagcgt ttgacgctgc ggttcatccc tgtggaccgt gaggatactg cgtactcgta 20520 caaggcgcgg ttcaccctag ctgtgggtga taaccgtgg ctggacatgg cttccacgta 20580 ctttgacatc cgcggcgtgc tggacagggg ccctactttt aagccctact ctggcactgc 20640 ctacaacgcc ctggctccca agggtgcccc aaatccttgc gaatgggatg aagctgctac 20700 tgctcttgaa ataaacctag aagaagagga cgatgacaac gaagacgaag tagacgagca 20760 agctgagcag caaaaaactc acgtatttgg gcaggcgcct tattctggta taaatattac 20820 aaaggagggt attcaaatag gtgtcgaagg tcaaacacct aaatatgccg ataaa acatt 20880 tcaacctgaa cctcaaatag gagaatctca gtggtacgaa acagaaatta atcatgcagc 20940 tgggagagtc ctaaaaaaga ctaccccaat gaaaccatgt tacggttcat atgcaaaacc 21000 cacaaatgaa aatggagggc aaggcattct tgtaaagcaa caaaatggaa agctagaaag 21060 tcaagtggaa atgcaatttt tctcaactac tgaggcagcc gcaggcaatg gtgataactt 21120 gactcctaaa gtggtattgt acagtgaaga tgtagatata gaaaccccag acactcatat 21180 ttcttacatg cccactatta aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat 21240 gcccaacagg cctaattaca ttgcttttag ggacaatttt attggtctaa tgtattacaa 21300 cagc acgggt aatatgggtg ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga 21360 tttgcaagac agaaacacag agctttcata ccagcttttg cttgattcca ttggtgatag 21420 aaccaggtac ttttctatgt ggaatcaggc tgttgacagc tatgatccag atgttagaat 21480 tattgaaaat catggaactg aagatgaact tccaaattac tgctttccac tgggaggtgt 21540 gattaataca gagactctta cca aggtaaa acctaaaaca ggtcaggaaa atggatggga 21600 aaaagatgct acagaatttt cagataaaaa tgaaataaga gttggaaata attttgccat 21660 ggaaatcaat ctaaatgcca acctgtggag aaatttcctg tactccaaca tagcgctgta 21720 tttgc ccgac aagctaaagt acagtccttc caacgtaaaa atttctgata acccaaacac 21780 ctacgactac atgaacaagc gagtggtggc tcccgggcta gtggactgct acattaacct 21840 tggagcacgc tggtcccttg actatatgga caacgtcaac ccatttaacc accaccgcaa 21900 tgctggcctg cgctaccgct caatgttgct gggcaatggt cgctatgtgc ccttccacat 21960 ccaggtgcct cagaagttct ttgccatta a aaacctcctt ctcctgccgg gctcatacac 22020 ctacgagtgg aacttcagga aggatgttaa catggttctg cagagctccc taggaaatga 22080 cctaagggtt gacggagcca gcattaagtt tgatagcatt tgcctttacg ccaccttctt 22140 ccccatggcc cacacaccg cctccacgct tgaggccatg cttagaaacg acaccaacga 22200 ccagtccttt aacgactatc tctccgccgc caacatgctc taccctatac ccgccaacgc 22260 taccaacgtg cccatatcca tcccctcccg caactgggcg gctttccgcg gctgggcctt 22320 cacgcgcctt aagactaagg aaaccccatc actgggctcg ggctacgacc cttattacac 22380 ctactctggc tctataccct acctagatgg aaccttttac ctca accaca cctttaagaa 22440 ggtggccatt acctttgact cttctgtcag ctggcctggc aatgaccgcc tgcttacccc 22500 caacgagttt gaaattaagc gctcagttga cggggagggt tacaacgttg cccagtgtaa 22560 catgaccaaa gactggttcc tggtacaaat gctagctaac tataacattg gctaccaggg 22620 cttctatatc ccagagagct acaaggaccg catgtactcc ttctttagaa acttccagcc 22680 catgagccgt caggtggtgg atgatactaa atacaaggac taccaacagg tgggcatcct 22740 acaccaacac aacaactctg gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca 22800 ggcctaccct gctaacttcc cctatccgct tataggcaag accgcagttg acagcattac 22860 ccagaaaaag tttctttgcg atcgcaccct ttggcgcatc ccattctcca gtaactttat 22920 gtccatgggc gcactcacag acctgggcca aaaccttctc tacgccaact ccgcccacgc 22980 gctagacatg acttttgagg tggatcccat ggacgagccc acccttctt t atgttttgtt 23040 tgaagtcttt gacgtggtcc gtgtgcacca gccgcaccgc ggcgtcatcg aaaccgtgta 23100 cctgcgcacg cccttctcgg ccggcaacgc cacaacataa agaagcaagc aacatcaaca 23160 acagctgccg ccatgggctc cagtgagcag gaactgaaag ccattgtcaa agatcttggt 23220 tgtgggccat atttttggg cacctatgac aagcgctttc caggctttgt ttctccac ac 23280 aagctcgcct gcgccatagt caatacggcc ggtcgcgaga ctgggggcgt acactggatg 23340 gcctttgcct ggaacccgca ctcaaaaaca tgctacctct ttgagccctt tggcttttct 23400 gaccagcgac tcaagcaggt ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc 23460 attgcttctt cccccgaccg ctgtataacg ctggaaaagt ccacccaaag cgtacagggg 23520 cccaactcgg ccgcctgtgg actattctgc tgcatgtttc tccacgcctt tgccaactgg 23580 ccccaaactc ccatggatca caaccccacc atgaacctta ttaccggggt acccaactcc 23640 atgctcaaca gtccccaggt acagcccacc ctgcgtcgca accaggaaca gctctacagc 23700 ttcctggagc gcc actcgcc ctacttccgc agccacagtg cgcagattag gagcgccact 23760 tctttttgtc acttgaaaaa catgtaaaaa taatgtacta gagacacttt caataaaggc 23820 aaatgctttt atttgtacac tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc 23880 gtttaaaaat caaaggggtt ctgccgcgca tcgctatgcg ccactggcag ggacacgttg 23940 cgatactggt gtttagtgct ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg 24000 aagttttcac tccacaggct gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat 24060 atcttgaagt cgcagttggg gcctccgccc tgcgcgcgcg agttgcgata cacagggttg 2412 0 cagcactgga acactatcag cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag 24180 atcagatccg cgtccaggtc ctccgcgttg ctcagggcga acggagtcaa ctttggtagc 24240 tgccttccca aaaagggcgc gtgcccaggc tttgagttg c actcgcaccg tagtggcatc 24300 aaaaggtgac cgtgcccggt ctgggcgtta ggatacagcg cctgcataaa agccttgatc 24360 tgcttaaaag ccacctgagc ctttgcgcct tcagagaaga acatgccgca agacttgccg 24420 gaaaactgat tggccggaca ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag 24480 atctgcacca catttcggcc ccaccggttc ttcacgatct tggccttgct agactgctcc 24540 ttcagc c ctctgcaaa cgactgcagg 24720 tacgcctgca ggaatcgccc catcatcgtc acaaaggtct tgttgctggt gaaggtcagc 24780 tgcaacccgc ggtgctcctc gttcagccag gtcttgcata cggccgccag agcttccact 24840 tggtcaggca gtagtttgaa gttcgccttt agatcgttat ccacgtggta cttgtccatc 24900 agcgcgcgcg cagcctccat gcccttctcc cacgcagaca cgatcggcac actcagcggg 24960 ttcatcaccg taatttcact t tccgcttcg ctgggctctt cctcttcctc ttgcgtccgc 25020 ataccacgcg ccactgggtc gtcttcattc agccgccgca ctgtgcgctt acctcctttg 25080 ccatgcttga ttagcaccgg tgggttgctg aaacccacca tttgtagcgc cacatct tct 25140 ctttcttcct cgctgtccac gattacctct ggtgatggcg ggcgctcggg cttgggagaa 25200 gggcgcttct ttttcttctt gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc 25260 gggctgggtg tgcgcggcac cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg 25320 atacgccgcc tcatccgctt ttttgggggc gcccggggag gcggcggcga cggggacggg 25380 gacgacacgt cctccatggt tgggggacgt t ccaccgatg ccgccaacgc gcctaccacc ttccccgtcg aggcaccccc gcttgaggag 25620 gaggaagtga ttatcgagca ggacccaggt tttgtaagcg aagacgacga ggaccgctca 25680 gtaccaacag aggataaaaa gcaagaccag gacaacgcag aggcaaacga ggaacaagtc 25740 gggcgggggg acgaaaggca tggcgactac ctagatgtgg gagacgacgt gctgttgaag 25800 catctgcagc gccagtgcgc cattatctgc gacgcgttgc aagagcgcag cgat gtgccc 25860 ctcgccatag cggatgtcag ccttgcctac gaacgccacc tattctcacc gcgcgtaccc 25920 cccaaacgcc aagaaaacgg cacatgcgag cccaacccgc gcctcaactt ctaccccgta 25980 tttgccgtgc cagaggtgct tgccacctat cacatctttt tccaaaactg caagataccc 26040 ctatcctgcc gtgccaaccg cagccgagcg gacaagcagc tggccttgcg gcagggcgct 26100 gtcatacctg atatcgcctc gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc 26160 gacgagaagc gcgcggcaaa cgctctgcaa caggaaaaca gcgaaaatga aagtcactct 26220 ggaggttgg tggaactcga gggtgacaac gcgcgcctag ccgtactaa a acgcagcatc 26280 gaggtcaccc actttgccta cccggcactt aacctacccc ccaaggtcat gagcacagtc 26340 atgagtgagc tgatcgtgcg ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa 26400 caaacagagg agggcctacc cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg 26460 cgcgagcctg ccgacttgga ggagcgacgc aaactaatga tggccgcagt gctcgttacc 26520 gtggagcttg agtgcatgca gcggttcttt gctgacccgg agatgcagcg caagctagag 26580 gaaacattgc actacacctt tcgacagggc tacgtacgcc aggcctgcaa gatctccaac 26640 gtggagctct gcaacctggt ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa 26 700 aacgtgcttc attccacgct caagggcgag gcgcgccgcg actacgtccg cgactgcgtt 26760 tacttatttc tatgctacac ctggcagacg gccatgggcg tttggcagca gtgcttggag 26820 gagtgcaacc tcaaggagct gcagaaactg ctaaagca aa acttgaagga cctatggacg 26880 gccttcaacg agcgctccgt ggccgcgcac ctggcggaca tcattttccc cgaacgcctg 26940 cttaaaaccc tgcaacaggg tctgccagac ttcaccagtc aaagcatgtt gcagaacttt 27000 aggaacttta tcctagagcg ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc 27060 gactttgtgc ccattaagta ccgcgaatgc cctccgccgc tttggggcca ctgctacctt 27120 ct gcagctag ccaactacct tgcctaccac tctgacataa tggaagacgt gagcggtgac 27180 ggtctactgg agtgtcactg tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc 27240 aattcgcagc tgcttaacga aagtcaaatt atcggtacct ttgagctgca gggtccctcg 27300 cctgacgaaa agtccgcggc tccggggttg aaactcactc cggggctgtg gacgtcggct 27360 taccttcgca aatttgtacc tgaggactac cacgcccacg agatta ggtt ctacgaagac 27420 caatcccgcc cgcctaatgc ggagcttacc gcctgcgtca ttacccaggg ccacattctt 27480 ggccaattgc aagccatcaa caaagcccgc caagagtttc tgctacgaaa gggacggggg 27540 gtttacttgg acccccagtc cggcga ggag ctcaacccaa tccccccgcc gccgcagccc 27600 tatcagcagc agccgcgggc ccttgcttcc caggatggca cccaaaaaga agctgcagct 27660 gccgccgcca cccacggacg aggaggaata ctgggacagt caggcagagg aggttttgga 27720 cgaggaggag gaggacatga tggaagactg ggagagccta gacgaggaag cttccgaggt 27780 cgaagaggtg tcagacgaaa caccgtcacc ctcggtcgca ttcccctcgc cggcgcc ggcta ccgct catggcgcgg 28020 gcacaagaac gccatagttg cttgcttgca agactgtggg ggcaacatct ccttcgcccg 28080 ccgctttctt ctctaccatc acggcgtggc cttcccccgt aacatcctgc attactaccg 28140 tcatctctac agcccatact gcaccggcgg cagcggcagc aacagcagcg gccacacaga 28200 agcaaaggcg accggatagc aagactctga caaagcccaa gaaatccaca gcggcggcag 28260 cagcag gagg aggagcgctg cgtctggcgc ccaacgaacc cgtatcgacc cgcgagctta 28320 gaaacaggat ttttcccact ctgtatgcta tatttcaaca gagcaggggc caagaacaag 28380 agctgaaaat aaaaaacagg tctctgcgat ccctcacccg cagctgcctg tat cacaaaa 28440 gcgaagatca gcttcggcgc acgctggaag acgcggaggc tctcttcagt aaatactgcg 28500 cgctgactct taaggactag tttcgcgccc tttctcaaat ttaagcgcga aaactacgtc 28560 atctccagcg gccacacccg gcgccagcac ctgttgtcag cgccattatg agcaaggaaa 28620 ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28680 aagactactc a acccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28740 acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28800 ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 2886 0 ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28920 gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28980 acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 29040 gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 29100 gtcaggca at cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 29160 ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 29220 ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcgg cggacg 29280 gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 29340 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt a actgtccta accctggatt acatcaagat cctctagtta 29580 atgtcaggtc gcctaagtcg attaactaga gtacccgggg atcttattcc ctttaactaa 29640 taaaaaaaaa taataaagca tcacttactt aaaatcagtt agcaaatttc tgtccagttt 29700 attcagcagc acctcc ttgc cctcctccca gctctggtat tgcagcttcc tcctggctgc 29760 aaactttctc cacaatctaa atggaatgtc agtttcctcc tgttcctgtc catccgcacc 29820 cactatcttc atgttgttgc agatgaagcg cgcaagaccg tctgaagata ccttcaaccc 29880 cgtgtatcca tatgacacgg aaaccggtcc tccaactgtg ccttttctta ctcctccctt 29940 tgtatccccc aatgggtttc aagagagtcc ccctggggta ctctctttgc gcctatccga 30000 acctctagtt acctccaatg gcatgcttgc gctcaaaatg ggcaacggcc tctctctgga 30060 cgaggccggc aaccttacct cccaaaatgt aaccactgtg agcccacctc tcaaaaaaac 30120 caagtcaaac ataaacct gg aaatatctgc acccctcaca gttacctcag aagccctaac 30180 tgtggctgcc gccgcacctc taatggtcgc gggcaacaca ctcaccatgc aatcacaggc 30240 cccgctaacc gtgcacgact ccaaacttag cattgccacc caaggacccc tcacagtgtc 30300 agaaggaaag ctagccctgc aaacatcagg ccccctcacc accaccgata gcagtaccct 30360 tactatcact gcctcacccc ctctaactac tgccactggt agcttgggca ttgact tgaa 30420 agagcccatt tatacacaaa atggaaaact aggactaaag tacggggctc ctttgcatgt 30480 aacagacgac ctaaacactt tgaccgtagc aactggtcca ggtgtgacta ttaataatac 30540 ttccttgcaa actaaagtta ctggagcctt gggttttga t tcacaaggca atatgcaact 30600 taatgtagca ggaggactaa ggattgattc tcaaaacaga cgccttatac ttgatgttag 30660 ttatccgttt gatgctcaaa accaactaaa tctaagacta ggacagggcc ctctttttat 30720 aaactcagcc cacaacttgg atattaacta caacaaaggc ctttacttgt ttacagcttc 30780 aaacaattcc aaaaagcttg aggttaacct aagcactgcc aaggggttga tgtttgacgc 3 0840 tacagccata gccattaatg caggagatgg gcttgaattt ggttcaccta atgcaccaaa 30900 cacaaatccc ctcaaaacaa aaattggcca tggcctagaa tttgattcaa acaaggctat 30960 ggttcctaaa ctaggaactg gccttagttt tgacagcaca ggtg ccatta cagtaggaaa 31020 caaaaataat gataagctaa ctttgtggac cggaataaac cctcccaccta actgtcaaat 31080 tgtggaaaac actaatacaa atgatggcaa acttacttta gttatagtaa aaaatggagg 31140 gcttgttaat ggctacgtgt ctctagttgg tgtatcagac actgtgaacc aaatgttcac 31200 aaaaagaca gcaaacatcc aattaagatt atattttgac tcttctggaa atctattaac 31260 tgaggaatca gacttaaaaa ttccacttaa aaataaatct tctacagcga ccagtgaaac 31320 tgtagccagc agcaaagcct ttatgccaag tactacagct tatcccttca acaccactac 31380 tagggatagt gaaaactaca ttcatggaat atgttactac atgactagtt atgatagaag 31440 tctatttccc ttgaacattt ctataatgct aaacagccgt atgatttctt ccaatgttgc 31500 ctatgccata caatttgaat ggaatctaaa tgcaagtgaa tctccagaaa gcaacatagc 31560 tacgctgacc acatccccct ttttcttttc ttacattaca gaagacgaca actaaagaat 31620 cgtttgtgtt atgtttcaac gtgttattt ttcaattgca gaaaatttca agtcattttt 31680 cattcagtag ta tagcccca ccaccacata gcttatacag atcaccgtac cttaatcaaa 31740 ctcacagaac cctagtattc aacctgccac ctccctccca acacacagag tacacagtcc 31800 tttctccccg gctggcctta aaaagcatca tatcatgggt aacagacata ttcttaggtg 31860 ttatattcca cacggt ttcc tgtcgagcca aacgctcatc agtgatatta ataaactccc 31920 cgggcagctc acttaagttc atgtcgctgt ccagctgctg agccacaggc tgctgtccaa 31980 cttgcggttg cttaacgggc ggcgaaggag aagtccacgc ctacatgggg gtagagtcat 32040 aatcgtgcat caggataggg cggtggtgct gcagcagcgc gcgaataaac tgctgccgcc 32100 gccgctccgt cctgcag gaa tacaacatgg cagtggtctc ctcagcgatg attcgcaccg 32160 cccgcagcat aaggcgcctt gtcctccggg cacagcagcg caccctgatc tcacttaaat 32220 cagcacagta actgcagcac agcaccacaa tattgttcaa aatcccacag tgcaaggcgc 32280 tgtatccaaa gctcatggcg gggaccag aacccacgtg gccatcatac cacaagcgca 32340 ggtagattaa gtggcgaccc ctcataaaca cgctggacat aaacattacc tcttttggca 32400 tgttgtaatt caccacctcc cggtaccata taaacctctg attaaacatg gcgccatcca 32460 ccaccatcct aaaccagctg gccaaaacct gcccgccggc tatacactgc agggaaccgg 32520 gactggaaca atgacagtgg agagcccagg actcgta acc atggatcatc atgctcgtca 32580 tgatatcaat gttggcacaa cacaggcaca cgtgcataca cttcctcagg attacaagct 32640 cctcccgcgt tagaaccata tcccagggaa caacccattc ctgaatcagc gtaaatccca 32700 cactgcaggg aagacctcgc acgtaactca c gttgtgcat tgtcaaagtg ttacattcgg 32760 gcagcagcgg atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa ggaggtagac 32820 gatccctact gtacggagtg cgccgagaca accgagatcg tgttggtcgt agtgtcatgc 32880 caaatggaac gccggacgta gtcatatttc ctgaagcaaa accaggtgcg ggcgtgacaa 32940 acagatctgc gtctccggtc tcgccgctta gatcgctct g tgtagtagtt gtagtatatc 33000 cactctctca aagcatccag gcgccccctg gcttcgggtt ctatgtaaac tccttcatgc 33060 gccgctgccc tgataacatc caccaccgca gaataagcca cacccagcca acctacacat 33120 tcgttctgcg agtcacacac gggaggagcg ggaagagctg gaagaaccat gttttttttt 33180 ttattccaaa agattatcca aaacctcaaa atgaagatct attaagtgaa cgcgctcccc 33240 tccggtggcg tggtcaaact ctacagccaa agaacagata atggcatttg taagatgttg 33300 cacaatggct tccaaaaggc aaacggccct cacgtccaag tggacgtaaa ggctaaaccc 33360 ttcagggtga atctcctcta taaacattcc agcaccttca accatgccca aataattctc 33420 atctcgccac cttctcaata tatctctaag caaatcccga atattaagtc cggccattgt 33480 aaaaatctgc tccagagcgc cctccacctt cagcctcaag cagcgaatca tgattgcaaa 33540 aattcaggtt cctcacagac ctgtataaga ttcaa aagcg gaacattaac aaaaataccg 33600 cgatcccgta ggtcccttcg cagggccagc tgaacataat cgtgcaggtc tgcacggacc 33660 agcgcggcca cgcgcaaaaa a gaaagcaca 33840 tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaaccaccac agaaaaagac 33900 accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata aaataacaaa 33960 aaaacattta aacattagaa gcctgtctta caacaggaa a aaacaaccctt ataagcataa 34020 gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga ttaaaaagca 34080 ccaccgacag ctcctcggtc a aaccctcct gcctaggcaa aatagcaccc tcccgctcca 34320 gaacaacata cagcgcttcc acagcggcag ccataacagt cagccttacc agtaaaaaag 34380 aaaacctatt aaaaaaacac cactcgacac ggcaccagct caatcagtca cagtgtaaaa 34440 aagggcc aag tgcagagcga gtatatatag gactaaaaaa tgacgtaacg gttaaagtcc 34500 acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca gaaacgaaag ccaaaaaacc 34560 cacaacttcc tcaaatcgtc acttccgttt tcccacgtta cgtcacttcc cattttaaga 34620 aaactacaat tcccaacaca tacaagttac tccgccctaa aacctacgtc acccgccccg 34680 ttcccacgcc ccg cgccacg tcacaaactc caccccctca ttatcatatt ggcttcaatc 34740caaaataagg tatattattg atgatg 34766 <210> 30 <211> 35726 <212> DNA <213> artificial sequence <220> <223> Adk35F2-Spike/E4orf6(mPGK)-E4dl-711(E4re#29) <400> 30 ttaattaaca tcatcaataa tataccttat tttggattga agccaatatg ataatgaggg 60 ggtggagttt gtgacgtggc gcggggcgtg ggaacggggc gggtgacgta gtagtgtggc 120 ggaagtgtga tgttgcaagt gtggcggaac acatgtaagc gacgg atgg gcaaaagtga 180 cgtttttggt gtgcgccggt gtacacagga agtgacaatt ttcgcgcggt tttaggcgga 240 tgttgtagta aatttgggcg taaccgagta agatttggcc attttcgcgg gaaaactgaa 300 taagaggaag tgaaatctga ataattt tgt gttactcata gcgcgtaata atttctgtaa 360 tagtaatcaa ttacggggtc attagttcat agcccatata at catatgcc aagtacgccc 600 cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 660 tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 720 cggttttggc agtacatcaa tgggcgtgga tagcggttt g actcacgggg atttccaagt 780 ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 840 aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag 900 gtctatataa gcagagctct ccctatcagt gatagagatc tccctatcag tgatagagat 960 cgtcgacgag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt 1020 gacctccata gaagacaccg ggaccgatcc agcctccgat ttgccaccat gtttgtgttc 1080 ctggtgctgc tgccactggt gtccagccag tgtgtgaacc tgaccaccag gacccaactt 1140 cctcctgcct acaccaactc ctt caccagg ggagtctact accctgacaa ggtgttcagg 1200 tcctctgtgc tgcacagcac ccaggacctg ttcctgccat tcttcagcaa tgtgacctgg tgatt gtgaa caatgccacc 1440 aatgtggtga ttaaggtgtg tgagttccag ttctgtaatg acccattcct gggagtctac 1500 taccacaaga acaacaagtc ctggatggag tctgagttca gggtctactc ctctgccaac 1560 aactgtacct ttgaatatgt gagccaacca ttcctga tgg acttggaggg caagcagggc 1620 aacttcaaga acctgaggga gtttgtgttc aagaacattg atggctactt caagatttac 1680 agcaaacaca caccaatcaa cctggtgagg gacctgccac agggcttctc tgccttgggaa 1740 ccactggtgg acctgccaat tggcatcaac atcaccaggt tccagaccct gctggctctg 1800 cacaggtcct acctgacacc tggagactcc tcctctggct ggacagcagg agcagcagcc 1860 tactatgtgg gctacctcca accaaggacc ttcctgctga aatacaatga gaatggcacc 1920 atcacagatg ctgtggactg tgccctggac ccactgtctg agaccaagtg taccctgaaa 1980 tccttcacag tggagaaggg catctaccag accagcaact tcagggtcca accaacaga g 2040 agcattgtga ggtttccaaa catcaccaac ctgtgtccat ttggagaggt gttcaatgcc 2100 accaggtttg cctctgtcta tgcctggaac aggaagagga ttagcaactg tgtggctgac 2160 tactctgtgc tctacaactc tgcctccttc agcaccttca agtgttatgg agtgagccca 2220 accaaactga atgacctgtg tttcaccaat gtctatgctg actcctttgt gattagggga 2280 gatgaggtga gacagattgc ccctggacaa acaggcaaga ttgctgacta caactacaaa 2340 ctgcctgatg acttcacagg ctgtgtgatt gcctggaaca gcaacaacct ggacagcaag 2400 gtgggaggca actacaacta cctctacaga ctgttcagga agagcaacct gaaaccattt 2460 gagaggggaca tcagcacaga gatttaccag gctggcagca caccatgtaa tggagtggag 2520 ggcttcaact gttactttcc actccaatcc tatggcttcc aaccaaccaa tggagtgggc 2580 taccaaccat acagggtggt ggtgctgtcc tttgaactgc tccatgcccc tgccacagtg 2640 tgtggaccaa agaagagcac caacctggtg aagaacaagt gtgtgaactt caacttcaat 2700 ggactgaca g gcacaggagt gctgacagag agcaacaaga agttcctgcc attccaacag 2760 tttggcaggg acattgctga caccacagat gctgtgaggg acccacagac cttggagatt 2820 ctggacatca caccatgttc ctttggagga gtgtctgtga ttacacctgg caccaacacc 2880 agcaacca gg tggctgtgct ctaccaggat gtgaactgta ctgaggtgcc tgtggctatc 2940 catgctgacc aacttacacc aacctggagg gtctacagca caggcagcaa tgtgttccag 3000 accagggctg gctgtctgat tggagcag catgtgaaca actcctatga gtgtgacatc 3060 ccaattggag caggcatctg tgcctcctac cagacccaga ccggtggcgg tgggtcgagg 3120 tctgtggcaa gccagagcat cattgcc tac acaatgagtc tgggagcaga gaactctgtg 3180 gcttacagca acaacagcat tgccatccca accaacttca ccatctctgt gaccacagag 3240 attctgcctg tgagtatgac caagacctct gtggactgta caatgtatat ctgtggagac 3300 agcacagagt gtagcaacct gctgct ccaa tatggctcct tctgtaccca acttaacagg 3360 gctctgacag gcattgctgt ggaacaggac aagaacaccc aggaggtgtt tgcccaggtg 3420 aagcagattt acaagacacc tccaatcaag gactttggag gcttcaactt cagccagatt 3480 ctgcctgacc caagcaagcc aagcaagagg tccttcattg aggacctgct gttcaacaag 3540 gtgaccctgg ctgatgctgg cttcatcaag caatatggag actgtctggg agacattgct 3600 gccaggggacc tgatttgtgc ccagaagttc aatggactga cagtgctgcc tccactgctg 3660 acagatgaga tgattgccca atacacctct gccctgctgg ctggcaccat cacctctggc 3720 tggacctttg gagcaggagc agcc ctccaa atcccatttg ctatgcagat ggcttacagg 3780 ttcaatggca ttggagtgac ccagaatgtg ctctatgaga accagaaact gtgctgaatg acat cctgag cagactggac 4020 aaggtggagg ctgaggtcca gattgacaga ctgattacag gcagactcca atccctccaa 4080 acctatgtga cccaacaact tatcagggct gctgagatta gggcatctgc caacctggct 4140 gccaccaaga tgagtgagtg tgtgctggga caaagcaaga gggtggact t ctgtggcaag 4200 ggctaccacc tgatgagttt tccacagtct gcccctcatg gagtggtgtt cctgcatgtg 4260 acctatgtgc ctgcccagga gaagaacttc accacagccc ctgccatctg ccatgatggc 4320 aaggctcact ttccaaggga gggagtgttt gtgagcaatg gcacccactg gtttgtgacc 4380 cagaggaact tctatgaacc acagattatc accacagaca acacctttgt gtctggcaac 4440 tgtgatgtgg tgattggcat tgtgaacaac acagtctatg acccactcca acctgaactg 4500 gactccttca aggaggaact ggacaaatac ttcaagaacc acaccagccc tgatgtggac 4560 ctggggagaca tctctggcat caatgcctct gtggtgaaca tccagaagga gattgacaga 4620 ctgaatgagg tggctaagaa cctgaatgag tccctgattg acctccaaga actgggcaaa 4680 tatgaacaat acatcaagtg gccatgaaaa ttgatcataa tcagccatac cacatttgta 4740 gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 4800 aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ata aagcaat 4860 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 4920 aaactcatca atgtatctta acgcggatcg ggtaggggag gcgcttttcc caaggcagtc 4980 tggagcatgc gctttagcag ccccgctggg cactt ggcgc tacacaagtg gcctctggcc 5040 tcgcacacat tccacatcca ccggtaggcg ccaaccggct ccgttctttg gtggcccctt 5100 cgcgccacct tctactcctc ccctagtcag gaagttcccc cccgccccgc agctcgcgtc 5160 gtgcaggacg tgacaaatgg aagtagcacg tctcactagt ctcgtgcaga tggacagcac 5220 cgctgagcaa tggaagcggg taggcctttg gggcagcggc caatagcagc tttgctcctt 5280 cgctttctgg gctcagaggc tgggaagggg tgggtccggg ggcgggctca ggggcgggct 5340 caggggcggg gcgggcgccc gaaggtcctc cggaggcccg gcattctgca cgcttcaaaa 5400 gcgcacgtct gccgcgctgt tctcctcttc ctcatctccg ggcctttcga aactacccca 5460 agctggccac catgactacg tccggcgttc catttggcat gacactacga ccaacacgat 5520 ctcggttgtc tcggcgcact ccgtacagta gggatcgtct acctcctttt gagacagaaa 5580 cccgcgctac catactggag gatcatccgc tgctgcccga atgtaacact ttgacaatgc 5640 acaacgtgag ttacgtgcga ggtcttccct gcagtgtggg atttacgctg attcaggaat 5700 gggttgtt cc ctgggatatg gttctaacgc gggaggagct tgtaatcctg aggaagtgta 5760 tgcacgtgg cctgtgttgt gccaacattg atatcatgac gagcatgatg atccatggtt 5820 acgagtcctg ggctctccac tgtcattgtt ccagtcccgg ttccctgcag tgtatagcc g 5880 gcgggcaggt tttggccagc tggtttagga tggtggtgga tggcgccatg tttaatcaga 5940 ggtttatatg gtaccgggag gtggtgaatt acaacatgcc aaaagaggta atgtttatgt 6000 ccagcgtgtt tatgaggggt cgccacttaa tctacctgcg cttgtggtat gatggccacg 6060 tgggttctgt ggtccccgcc atgagctttg gatacagcgc cttgcactgt gggattttga 6120 acaatattgt ggtg ctgtgc tgcagttact gtgctgattt aagtgagatc agggtgcgct 6180 gctgtgcccg gaggacaagg cgccttatgc tgcgggcggt gcgaatcatc gctgaggaga 6240 ccactgccat gttgtattcc tgcaggacgg agcggcggcg gcagcagttt attcgcgc gc 6300 tgctgcagca ccaccgccct atcctgatgc acgattatga ctctaccccc atgtagaagc 6360 ttggggatca attctctaga gctcgctgat cagcctcgac tgtgccttct agttgccagc 6420 catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg 6480 tcctttccta ataaaatgag gaaattgcat cgcattgtct gaggtaggt cattctattc 6540 tggggggtgg ggtggggcag gacagca agg gggaggattg ggaagacaat agcaggcatg 6600 ctggggatgc ggtgggctct atggcttctg aggaaattgg gcgtggctta agggtgggaa 6660 agaatatata aggtgggggt cttatgtagt tttgtatctg tttgcagca gccgccgccg 6720 ccatgagcac caactc gttt gatggaagca ttgtgagctc atatttgaca acgcgcatgc 6780 ccccatgggc cggggtgcgt cagaatgtga tgggctccag cattgatggt cgccccgtcc 6840 tgcccgcaaa ctctactacc ttgacctacg agaccgtgtc tggaacgccg ttggagactg 6900 cagcctccgc cgccgcttca gccgctgcag ccaccgcccg cgggattgtg actgactttg 6960 ctttcctgag cccgcttgca ag cagtgcag cttcccgttc atccgcccgc gatgacaagt 7020 tgacggctct tttggcacaa ttggattctt tgacccggga acttaatgtc gtttctcagc 7080 agctgttgga tctgcgccag caggtttctg ccctgaaggc ttcctcccct cccaatgcgg 7140 tttaaaacat aaataaaaaa ccagactctg tttggatttg gatcaagcaa gtgtcttgct 7200 gtctttattt aggggttttg cgcgcgcggt aggcccggga ccagcggtct cggtcgttga 7260 gggtcctgtg tattttttcc aggacgtggt aaaggtgact ctggatgttc agatacatgg 7320 gcataagccc gtctctgggg tggaggtagc accactgcag agcttcatgc tgcggggtgg 7380 tgttgtagat gatccagtcg tagcaggagc gctgggcgtg gtgcc taaaa atgtctttca 7440 gtagcaagct gattgccagg ggcaggccct tggtgtaagt gtttacaaag cggttaagct 7500 gggatgggtg catacgtggg gatatgagat gcatcttgga ctgtattttt aggttggcta 7560 tgttcccagc catatccctc cggggattca tgttgtgca g aaccaccagc acagtgtatc 7620 cggtgcactt gggaaatttg tcatgtagct tagaaggaaa tgcgtggaag aacttggaga 7680 cgcccttgtg acctccaaga ttttccatgc attcgtccat aatgatggca atgggcccac 7740 gggcggcggc ctgggcgaag atatttctgg gatcactaac gtcatagttg tgttccagga 7800 tgagatcgtc ataggccatt tttacaaagc gcgggcggag ggtgccagac tgcggtataa 7860 tggttccatc cggcccaggg gcgtagttac cctcacagat ttgcatttcc cacgctttga 7920 gttcagatgg ggggatcatg tctacctgcg gggcgatgaa gaaaacggtt tccggggtag 7980 gggagatcag ctgggaagaa agcaggtt cc tgagcagctg cgacttaccg cagccggtgg 8040 gcccgtaaat cacacctatt accgggtgca actggtagtt aagagagctg cagctgccgt 8100 catccctgag caggggggcc acttcgttaa gcatgtccct gactcgcatg ttttccctga 8160 ccaaatccgc cagaaggcgc tcgccgccca gcgatagcag ttcttgcaag gaagcaaagt 8220 ttttcaacgg tttgagaccg tccgccgtag gcatgctttt gagcgtttga c caagcagtt 8280 ccaggcggtc ccacagctcg gtcacctgct ctacggcatc tcgatccagc atatctcctc 8340 gtttcgcggg ttggggcggc tttcgctgta cggcagtagt cggtgctcgt ccagacgggc 8400 cagggtcatg tctttccacg gg cgcagggt cctcgtcagc gtagtctggg tcacggtgaa 8460 ggggtgcgct ccgggctgcg cgctggccag ggtgcgcttg aggctggtcc tgctggtgct 8520 gaagcgctgc cggtcttcgc cctgcgcgtc ggccaggtag catttgacca tggtgtcata 8580 gtccagcccc tccgcggcgt ggcccttggc gcgcagcttg cccttggagg aggcgccgca 8640 cgaggggcag tgcagacttt tgagggcgta gagcttgggc gcgagaaata ccgattccgg 8 700 ggagtaggca tccgcgccgc aggccccgca gacggtctcg cattccacga gccaggtgag 8760 ctctggccgt tcggggtcaa aaaccaggtt tcccccatgc tttttgatgc gtttcttacc 8820 tctggtttcc atgagccggt gtccacgctc ggtgac gaaa aggctgtccg tgtccccgta 8880 tacagacttg agaggcctgt cctcgagcgg tgttccgcgg tcctcctcgt atagaaactc 8940 ggaccactct gagacaaagg ctcgcgtcca ggccagcacg aaggaggcta agtgggaggg 9000 gtagcggtcg ttgtccacta gggggtccac tcgctccagg gtgtgaagac acatgtcgcc 9060 ctcttcggca tcaaggaagg tgattggttt gtaggtgtag gccacgtgac cgggtgttcc 9120 tgaagggggg ct ataaaagg gggtgggggc gcgttcgtcc tcactctctt ccgcatcgct 9180 gtctgcgagg gccagctgtt ggggtgagta ctccctctga aaagcgggca tgacttctgc 9240 gctaagattg tcagtttcca aaaacgagga ggatttgata ttcacctggc ccgc ggtgat 9300 gcctttgagg gtggccgcat ccatctggtc agaaaagaca atctttttgt tgtcaagctt 9360 ggtggcaaac gacccgtaga gggcgttgga cagcaacttg gcgatggagc gcagggtttg 9420 gtttttgtcg cgatcggcgc gctccttggc cgcgatgttt agctgcacgt attcgcgcgc 9480 aacgcaccgc cattcgggaa agacggtggt gcgctcgtcg ggcaccaggt gcacgcgcca 9540 accgc ggttg tgcagggtga caaggtcaac gctggtggct acctctccgc gtaggcgctc 9600 gttggtccag cagaggcggc cgcccttgcg cgagcagaat ggcggtaggg ggtctagctg 9660 cgtctcgtcc ggggggtctg cgtccacggt aaagaccccg ggcagcaggc gcgcgt cgaa 9720 gtagtctatc ttgcatcctt gcaagtctag cgcctgctgc catgcgcggg cggcaagcgc 9780 gcgctcgtat gggttgagtg ggggacccca tggcatgggg tgggtgagcg cggaggcgta 9840 catgccgcaa atgtcgtaaa cgtagagggg ctctctgagt attccaagat atgtagggta 9900 gcatcttcca ccgcggatgc tggcgcgcac gtaatcgtat agttcgtgcg agggagcgag 9960 gaggtcggga ccgaggttgc tacgggcg gg ctgctctgct cggaagacta tctgcctgaa 10020 gatggcatgt gagttggatg atatggttgg acgctggaag acgttgaagc tggcgtctgt 10080 gagacctacc gcgtcacgca cgaaggaggc gtaggagtcg cgcagcttgt tgaccagctc 10140 ggcggtgacc tgcacgtcta gggcgcagta gtccagggtt tccttgatga tgtcatactt 10200 atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc ggtctttcca 10260 gtactcttgg atcggaaacc cgtcggcctc cgaacggtaa gagcctagca tgtagaactg 10320 gttgacggcc tggtaggcgc agcatccctt ttctacgggt agcgcgtatg cctgcgcggc 10380 cttccggagc gaggtgtggg tgagcgcaaa ggtgtccctg accatgactt tgaggtactg 10440 gtatttgaag tcagtgtcgt cgcatccgcc ctgctcccag agcaaaaagt ccgtgcgctt 10500 tttggaacgc ggatttggca gggcgaaggt gacatcgttg aagagtatct ttcccgcgcg 10560 a ggcataaag ttgcgtgtga tgcggaaggg tcccggcacc tcggaacggt tgttaattac 10620 ctgggcggcg agcacgatct cgtcaaagcc gttgatgttg tggcccacaa tgtaaagttc 10680 caagaagcgc gggatgccct tgatggaagg caatttttta agttcctcgt aggtgagctc 10740 ttcaggggag ctgagcccgt gctctgaaag ggcccagtct gcaagatgag ggttggaagc 10800 gacgaatgag ctccacaggt cacgggccat tagcatttgc aggtggt cgc gaaaggtcct 10860 aaactggcga cctatggcca ttttttctgg ggtgatgcag tagaaggtaa gcgggtcttg 10920 ttcccagcgg tcccatccaa ggttcgcggc taggtctcgc gcggcagtca ctagaggctc 10980 atctccgccg aacttcatga ccagcatgaa gggcacgagc tgcttcccaa aggcccccat 11040 ccaagtatag gtctctacat cgtaggtgac aaagagacgc tcggtgcgag gatgcgagcc 11100 gatcgggaag c gcgcacaag 11280 gaagcagagt gggaatttga gcccctcgcc tggcgggttt ggctggtggt cttctacttc 11340 ggctgcttgt ccttgaccgt ctggctgctc gaggggagtt acggtggatc ggaccaccac 11400 gccgcgcgag cccaaagtcc agatgt ccgc gcgcggcggt cggagcttga tgacaacatc 11460 gcgcagatgg gagctgtcca tggtctggag ctcccgcggc gtcaggtcag gcgggagctc 11520 ctgcaggttt acctcgcata gacgggtcag ggcgcgggct agatccaggt gatacctaat 11580 ttccaggggc tggttggtgg cggcgtcgat ggcttgcaag aggccgcatc cccgcggcgc 11640 gactacggta ccgcgcggcg ggcggtgggc cgcgggggtg tccttggatg atgcatc taa 11700 aagcggtgac gcgggcgagc ccccggaggt agggggggct ccggacccgc cgggagaggg 11760 ggcaggggca cgtcggcgcc gcgcgcgggc aggagctggt gctgcgcgcg taggttgctg 11820 gcgaacgcga cgacgcggcg gttgat ctcc tgaatctggc gcctctgcgt gaagacgacg 11880 ggcccggtga gcttgaacct gaaagagagt tcgacagaat caatttcggt gtcgttgacg 11940 gcggcctggc gcaaaatctc ctgcacgtct cctgagttgt cttgataggc gatctcggcc 12000 atgaactgct cgatctcttc ctcctggaga tctccgcgtc cggctcgctc cacggtggcg 12060 gcgaggtcgt tggaaatgcg ggccatgagc tgcgagaagg cgttgaggcc tccctcgttc 12120 cagacgcggc tgtagaccac gcccccttcg gcatcgcggg cgcgcatgac cacctgcgcg 12180 agattgagct ccacgtgccg ggcgaagacg gcgtagtttc gcaggcgctg aaagaggtag 12240 ttgagggtgg tggcggtgtg ttctgccacg aagaagtaca ta acccagcg tcgcaacgtg 12300 gattcgttga tatcccccaa ggcctcaagg cgctccatgg cctcgtagaa gtccacggcg 12360 aagttgaaaa actgggagtt gcgcgccgac acggttaact cctcctccag aagacggatg 12420 agctcggcga cagtgtcgcg cacctcgcgc tcaaaggcta caggggcctc ttcttcttct 12480 tcaatctcct cttccataag ggcctcccct tcttcttctt ctggcggcgg tgggggaggg 12540 gggacac ggc ggcgacgacg gcgcaccggg aggcggtcga caaagcgctc gatcatctcc 12600 ccgcggcgac ggcgcatggt ctcggtgacg gcgcggccgt tctcgcgggg gcgcagttgg 12660 aagacgccgc ccgtcatgtc ccggttatgg gttggcgggg ggct gccatg cggcagggat 12720 acggcgctaa cgatgcatct caacaattgt tggttaggta ctccgccgcc gagggacctg 12780 agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag 12840 tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg 12900 gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac 12960 agaagcacca tgtcc ttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag 13020 gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc 13080 acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctg c ggcggcggcg 13140 gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc 13200 ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc 13260 gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg 13320 gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc 13380 tcggtgtacc tgagacgcga gtaagccctc ga gtcaaata cgtagtcgtt gcaagtccgc 13440 accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt 13500 agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg 13560 tacctggaca tcc aggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg 13620 cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc 13680 aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct 13740 tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc 13800 cgtatccggc cgtccgccgt gatccatgcg gttaccgccc g t cgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc 14040 cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg 14100 caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca 14160 gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca 14220 gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagg gg cgacatccgc 14280 ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct 14340 ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc 14400 aagggtgcag ctgaagcgtg atac gcgtga ggcgtacgtg ccgcggcaga acctgtttcg 14460 cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga 14520 gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc 14580 gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata 14640 cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac 1 4700 gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc 14760 gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca 14820 cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg 14880 ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag 14940 cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc 15000 ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt 15060 ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa 15120 cgagc gcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct 15180 gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc 15240 ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgc gccc tggaggcagc 15300 tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga 15360 ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt 15420 tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag 15480 ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg 15540 actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt 15600 ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta 15660 aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg 15720 ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg 15780 gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg 15840 ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga 15900 caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa 15960 agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag 16020 accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc 16080 acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg 161 40 ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg 16200 ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag 16260 attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta 16320 aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag 16380 gaggagcgca ttttgcgcta cgtgcagca g agcgtgagcc ttaacctgat gcgcgacggg 16440 gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc 16500 tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac 16560 cccgagt att tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac 16620 accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac 16680 agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag 16740 gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg 16800 gccccgcggt cagatgctag tagcccattt ccaagcttga taggg tctct taccagcact 16860 cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag 16920 ccgcagcgcg aaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg 16980 gacaagatga gtagatggaa gacgtacgc g caggagcaca gggacgtgcc aggcccgcgc 17040 ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac 17100 tcggcagacg acagcagcgt cctggatttg ggaggggagtg gcaacccgtt tgcgcacctt 17160 cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc 17220 accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtat g cggcgcgcgg 17280 cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg 17340 cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt 17400 acctgcggcc taccgggggg agaa acagca tccgttactc tgagttggca cccctattcg 17460 acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc 17520 agaacgacca cagcaacttt cgcgg gtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt 17760 gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga 17820 acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaa agcg 17880 acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc 17940 ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag 18000 gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc 18060 aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg 18120 cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg 18180 gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag 18240 ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg 1 8300 ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg 18360 ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg 18420 acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca 18480 gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc 18540 tttgcactcc tgacgtaacc tg cggctcgg agcaggtcta ctggtcgttg ccagacatga 18600 tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg 18660 ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac 1872 0 tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt 18780 tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct tga gcaagca tgtccatcct tatatcgccc agcaataaca 19020 caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc 19080 aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc 19140 gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact 19200 acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg 19260 gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc 19320 gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca 19380 ccggccgacg ggcggccatg cgggccgctc ga aggctggc cgcgggtatt gtcactgtgc 19440 cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc 19500 agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg 19560 tgcgc acccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt 19620 gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag 19680 agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt 19740 acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg 19800 acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag t ggaaaggtc 19860 gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct 19920 ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc 19980 aggccaacga gcgcctcg gg ga gtttgcct acggaaagcg gcataaggac atgctggcgt 20040 tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc 20100 tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg 20160 cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa 20220 tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc 20280 cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg 20340 ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg 20400 ccgcggtgca ggcggtcgct gcggccgc gt ccaagacctc tacggaggtg caaacggacc 20460 cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg 20520 ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc 20580 gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa 20640 cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg 20700 ctc gcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt 20760 aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg 20820 tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggcc ggccac ggcctgacgg 20880 gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg 20940 gtatcctgcc cctccttat ccactgatcg ccgcggcgat tggcgccgtg cccggaattg 21000 catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc 21060 aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa 211 20 gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg 21180 caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc 21240 ggcattaaaa atttcggttc caccgttaag aactatggca gcaagg cctg gaacagcagc 21300 acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat 21360 ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag 21420 attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca 21480 gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg 21540 acgcaaatag acgagcctcc ctcgtacga g gaggcactaa agcaaggcct gcccaccacc 21600 cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac 21660 ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt 21720 gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg 21780 cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct ggggggtgcaa 21840 tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg 21900 tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac 21960 cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta 22020 cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa 22080 caagtttaga aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg 22140 tt tgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg 22200 gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat 22260 ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc 22320 cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga 22380 aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtag acgagc aagctgagca 22440 gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg 22500 tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga 22560 acctcaaata ggagaatctc agtggtacga a acagaaatt aatcatgcag ctgggagagt 22620 cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga 22680 aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga 22740 aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa 22800 agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata ttt cttacat 22860 gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag 22920 gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg 22980 taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttg caaga 23040 cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta 23100 cttttctatg aa aaagatgc 23280 tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa 23340 tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga 23400 caagctaaag tacagtcctt ccaacgtaa a aatttctgat aacccaaaca cctacgacta 23460 catgaacaag cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg 23520 ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct 23580 gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgg cccttccaca tccaggtgcc 23640 tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg 23700 gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt 23760 tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tcccccatggc 23820 ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt 23880 taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt 23940 gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct 24000 taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg 24060 ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat 24120 tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt 24180 tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa 24240 agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat 24300 cccaga gagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg 24360 tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca 24420 caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc 24480 tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa 24540 gtttctttgc gatcgcac cc tttggcgcat cccattctcc agtaacttta tgtccatggg 24600 cgcactcaca gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat 24660 gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt 247 20 tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac 24780 gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc 24840 gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca 24900 tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc 24960 tgcgccatag tcaatacggc cggt cgcgag actgggggcg tacactggat ggcctttgcc 25020 tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga 25080 ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct 2 5140 tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg 25200 gccgcctggg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact t tctttttgt 25440 cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt 25500 tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa 25560 tcaaaggggt tctgccgcgc atc gctatgc gccactggca gggacacgtt gcgatactgg 25620 tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca 25680 ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag 25740 tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg 25800 aacactatca gcgccgggtg gtgcacgctg gccagcac gc tcttgtcgga gatcagatcc 25860 gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc 25920 aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga 25980 ccgtgcccgg tct gggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa 26040 gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga 26100 ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc 26160 acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg 26220 cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctcc ttatt tatcataatg 26280 cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg 26340 cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc 26400 aggaatcgcc ccatcatcgt caca aaggtc ttgttgctgg tgaaggtcag ctgcaacccg 26460 cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc 26520 agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc 26580 gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc 26640 gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc 26700 gccactgggt cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg 26760 attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc 26820 tcgctgtcca cgattacctc tggtgatggc gggcgctc gg gcttgggaga agggcgcttc 26880 tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt 26940 gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc 27000 ctcatccgct ttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg 27060 tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcg c 27120 tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca 27180 gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat 27240 gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg 27300 attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca 27360 gaggataaaa agcaagacca ggacaacgca gaggcaaacg agga acaagt cgggcggggg 27420 gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag 27480 cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata 27540 gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc 27600 caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg 27660 ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc 27720 cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct 27780 gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggac g cgacgagaag 27840 cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg 27900 gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc 27960 cactttgcct acccggcact taacctac cc cccaaggtca tgagcacagt catgagtgag 28020 ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag 28080 gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct 28140 gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt 28200 gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaaacattg 28260 cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc 28320 tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt 28380 cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt 28440 ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac 28500 ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac 28560 gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc 28620 ctgcaacagg gtctgccaga cttcaccagt caagcatgt tgcagaactt taggaacttt 28680 atcctagagc gctca ggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg 28740 cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta 28800 gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg 288 60 gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag 28920 ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa 28980 aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc 29040 aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc 29100 ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg 29160 caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg 29220 gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag 29280 cag ccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc 29340 acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga 29400 ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt 29460 gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc 29520 aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg 29580 ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc 29640 gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa 29700 cgccatagt t gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct 29760 tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta 29820 cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc 29880 gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag 29940 gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga 30000 tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa 30060 taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc 30120 agcttcggcg cac gctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc 30180 ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc 30240 ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc 30300 cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact 30360 caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacgga atac 30420 gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata 30480 accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca 30540 ctgtggtact tcccagagac gcccaggccg aagttcagat gact aactca ggggcgcagc 30600 ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa 30660 tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc 30720 cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa 30780 tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat 30840 ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact 30900 atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact 30960 gaatgttaag tggagaggca gagcaactgc gcctgaa aca cctggtccac tgtcgccgcc 31020 acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata 31080 tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga 31140 ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca 31200 ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt 3126 0 cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa 31320 ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag 31380 cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct 31440 ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt 31500 catgttgttg cagatgaagc gcgcaagacc gg catgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg 31740 caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa 31800 cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc 3 1860 cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac 31920 cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa 31980 gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac 32040 tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat 32100 ttatacacaa aatggaaaac taggactaa a gtacggggct cctttgcatg taacagacga 32160 cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca 32220 aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc 32280 aggaggacta aggatt gatt ctcaaaacag acgccttata cttgatgtta gttatccgtt 32340 tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc 32400 ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc 32460 caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat 32520 agccattaat gcaggagatg ggcttgaatt tggtt cacct aatgcaccaa acacaaatcc 32580 cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa 32640 actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa 32700 tgataagcta actttgtgga ccgga ataaa ccctccacct aactgtcaaa ttgtggaaaa 32760 cactaataca aatgatggca aacttacttt agttatagta aaaaatggag ggcttgttaa 32820 tggctacgtg tctctagttg gtgtatcaga cactgtgaac caaatgttca cacaaaagac 32880 agcaaacatc caattaagat tatattttga ctcttctgga aatctattaa ctgaggaatc 32940 agacttaaaa attccactta aaaataaatc ttctacagc g accagtgaaa ctgtagccag 33000 cagcaaagcc tttatgccaa gtactacagc ttatcccttc aacaccacta ctagggatag 33060 tgaaaactac attcatggaa tatgttacta catgactagt tatgatagaa gtctatttcc 33120 cttgaacatt tctataatgc taaacagccg tatgatttct tccaatgttg cctatgccat 33180 acaatttgaa tggaatctaa atgcaagtga atctccagaa agcaacatag ctacgctgac 33240 cacatccccc tttttctttt cttacattac agaagacgac aactaaagaa tcgtttgtgt 33300 tatgtttcaa cgtgtttatt tttcaattgc agaaaatttc aagtcatttt tcattcagta 33360 gtatagcccc accaccacat agcttataca gatcaccgta ccttaatcaa actcacagaa 33420 ccctagtatt caacctgcca cctccctccc aacacacaga gtacacagtc ctttctcccc 33480 ggctggcctt aaaaagcatc atatcatggg taacagacat attcttaggt gttatattcc 33540 acacggtttc ctgtcgagcc aaacgctcat cagtgatatt aataaactcc ccgggcagct 33600 cacttaagtt catgtcgctg tccagctgct gagccacagg ctgctgtcca acttgcggtt 33660 gcttaacggg cggcgaagga gaagtccacg cgttgtgcat tgtcaaagtg ttacattcgg 33720 gcagcagcgg atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa ggaggtagac 33780 gatccctact gtacggagtg cgccgagaca accgagatcg tgttggtcgt agtgtcatgc 33840 caaatggaac gccggacgta gtcatatttc ctgaagcaaa accaggtgcg ggcgtgacaa 33900 acagatctgc gtctccggtc tcgccgctta gatcgctctg tgtagtagtt gtagtatatc 33960 cactctctca aagcatccag gcgccccctg gcttcgggtt ctatgtaaac tccttcatgc 34020 gccgctgccc tgataacatc caccaccgca gaataagcca cacccagcca acctacacat 34080 tcgttctgcg agtcacacac gggaggagcg ggaagagctg gaagaaccat gttttttttt 34140 ttattccaaa agattatcca aaacctcaaa atgaagatct attaagtgaa cgcgctcccc 34200 tccggtggcg tggtcaaact ctacagccaa agaacagata atggcatttg taagatgttg 342 60 cacaatggct tccaaaaggc aaacggccct cacgtccaag tggacgtaaa ggctaaaccc 34320 ttcagggtga atctcctcta taaacattcc agcaccttca accatgccca aataattctc 34380 atctcgccac cttctcaata tatctctaag caaatcccga atattaagtc cgg ccattgt 34440 aaaaatctgc tccagagcgc cctccacctt cagcctcaag cagcgaatca tgattgcaaa 34500 aattcaggtt cctcacagac ctgtataaga at actcggag ctatgctaac cagcgtagcc ccgatgtaag cttgttgcat gggcggcgat 34740 ataaaatgca aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa agaaagcaca 34800 tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaac caccac agaaaaagac 34860 accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata aaataacaaa 34920 aaaacattta aacattagaa gcctgtctta caacaggaaa aacaaccctt ataagcataa 34980 gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga ttaaaaagca 35040 ccaccgacag ctcctcggtc atgtccggag tcataatgta agactcggta aacacatcag 35100 gttgattcac atcggtcagt gctaaa aagc gaccgaaata gcccggggga atacataccc 35160 gcaggcgtag agacaacatt acagccccca taggaggtat aacaaaatta ataggagaga 35220 aaaacacata aacacctgaa aaaccctcct gcctaggcaa aatagcaccc tcccgctcca 35280 gaacaacata cagcgcttcc acagc ggcag ccataacagt cagccttacc agtaaaaaag 35340 aaaacctatt aaaaaaacac cactcgacac ggcaccagct caatcagtca cagtgtaaaa 35400 aagggccaag tgcagagcga gtatatatag gactaaaaaa tgacgtaacg gttaaagtcc 35460 acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca gaaacgaaag ccaaaaaacc 35520 cacaacttcc tcaaatcgtc acttccgttt tcccacgtta cgtcacttcc cattttaaga 35580 aaactacaat tcccaacaca tacaagttac tccgccctaa aacctacgtc acccgccccg 35640 ttcccacgcc ccgcgccacg tcacaaactc caccccctca ttatcatatt ggcttcaatc 35700caaaataa gg tatattattg atgatg 35726

Claims (8)

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) recombinant spike protein expression vector containing a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the spike protein has been removed and a GGGGS linker sequence has been introduced. as,
The recombinant spike protein expression vector is characterized in that derived from the adenovirus vector described in the nucleotide sequence of SEQ ID NO: 21, the recombinant spike protein expression vector.
According to claim 1,
Characterized in that the recombinant spike protein is described by the nucleotide sequence of SEQ ID NO: 12, the recombinant spike protein expression vector.
According to claim 1,
The recombinant spike protein expression vector is characterized in that described in the nucleotide sequence of SEQ ID NO: 27, recombinant spike protein expression vector.
According to any one of claims 1 to 3,
The recombinant spike protein expression vector is characterized in that the antigen expression level is high, the recombinant spike protein expression vector.
According to any one of claims 1 to 3,
The recombinant spike protein expression vector is characterized in that the amount of antibody production is high, the recombinant spike protein expression vector.
According to any one of claims 1 to 3,
The recombinant spike protein expression vector is characterized in that the antibody production expression period is increased, the recombinant spike protein expression vector.
A vaccine for preventing or treating SARS-CoV-2 virus infection, comprising the recombinant spike protein expression vector of claim 1 as an active ingredient.
(1) constructing a vector containing a polynucleotide encoding a recombinant spike protein in which the cleavage recognition sequence between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a GGGGS linker sequence is introduced;
(2) amplifying the spike protein gene in the vector: and
(3) linking the amplified gene with an adenovirus vector represented by the nucleotide sequence of SEQ ID NO: 1;
A method for producing the recombinant spike protein expression vector of claim 1, comprising a.

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