RU2816645C1 - Novel recombinant coronavirus spike protein encoding its polynucletide, vector containing polynucletide, and vaccine for preventing or treating coronavirus infection containing vector - Google Patents

Abstract

FIELD: biotechnology.

SUBSTANCE: described is a recombinant spike protein, in which a cleavage site between the genes S1 and S2 of the spike protein of the coronavirus is removed and a linker sequence is introduced, where recombinant spike protein is used to produce a vaccine for preventing or treating coronavirus infection, where antigen, spike protein linked by linker sequence, has high stability and high level of antigen expression. Linker consists of GGGGS. Also described is a polynucleotide coding a recombinant spike protein, in which the cleavage site between the genes S1 and S2 of the coronavirus spike protein is removed and a linker sequence is introduced, where the antigen, the spike protein linked by the linker sequence, has high stability and high level of antigen expression, and where the linker consists of GGGGS. What is disclosed is an adenoviral vector containing said polynucleotide. Also disclosed is a vaccine for preventing or treating coronavirus infection, containing said vector. Also disclosed is a method for preventing or treating coronavirus infection, comprising a step of administering said vector.

EFFECT: invention extends the range of products for preventing or treating coronavirus infection.

13 cl, 16 dwg, 4 tbl, 10 ex

Description

BACKGROUND OF THE ART

1. Field of technology to which the invention relates

The present invention relates to a new recombinant coronavirus spike protein, a polynucleotide encoding it, a vector containing the polynucleotide, and a vaccine for the prevention or treatment of coronavirus infection containing the vector.

2. Description of the prior art

Coronavirus, which causes severe respiratory illness and death, is classified as an RNA virus belonging to the family Coronaviridae, and coronavirus infection is defined as a respiratory syndrome caused by infection with a coronavirus. Among the viruses belonging to the Coronaviridae, a total of seven types of viruses are known to infect humans, including four types that cause the common cold (229E, OC43, NL63, and HKU1), two types that cause severe pneumonia (SARS-CoV and MERS-CoV), and SARS-CoV-2, the virus responsible for this pandemic. Three types of viruses that cause severe pneumonia (SARS-CoV, MERS-CoV and SARS-CoV-2) have spread throughout the world, starting with SARS-CoV in 2002, followed by MERS-CoV in 2012, and current SARS-CoV-2, which has high gene sequence homology with SARS-CoV.

As a genome, coronaviruses (Coronaviridae) have unstable RNAs, which results in mutations being easy to occur, and due to these characteristics, they are able to spread among both animals and humans. To date, research has shown that SARS-CoV was transmitted to humans from civet cats, and MERS-CoV was transmitted to humans from dromedary camels. Based on these cases, coronaviruses from other species that use animals as hosts are capable of evolving into mutant viruses that infect humans.

The first reports of SARS-CoV-2 appeared at the end of 2019. Compared to SARS-CoV, which originated in China in 2002, SARS-CoV has a higher severity, but SARS-CoV-2 is more transmissible due to mutations in the spike protein, the binding site of SARS-CoV-2 to cellular receptor. This led to a worldwide pandemic. Common signs of infection include respiratory symptoms, fever, cough, difficulty breathing and shortness of breath. In more severe cases, the infection can cause pneumonia, severe acute respiratory syndrome, kidney failure, and even death.

Currently, many countries and institutions are racing to develop vaccines to eradicate the COVID-19 pandemic. Depending on the production method, the types of preventive vaccines are classified into inactivated vaccines, attenuated vaccines, protein subunit vaccines, viral vector vaccines, DNA vaccines and mRNA vaccines. Inactivated vaccines and attenuated live vaccines, which have traditionally been widely used as vaccine preparations, have the advantage of a simple manufacturing process, but inactivated vaccines do not induce a high level of immune response, and attenuated live vaccines are associated with the risk of re-establishing pathogenicity through mutations. Because protein subunit vaccines are poor at eliciting an immune response, the need to use them in conjunction with an immune response enhancer poses a concern.

With the development of biotechnology, the development of vaccine drugs based on new platforms has begun, one of which is a vaccine based on a viral vector. Vector-based vaccines activate an immune response by highly efficient delivery of vaccine antigen genes into human cells to produce antigenic proteins in the body. Vaccines based on viral vectors are safe and induce a high level of immune response, so effective immunization is possible with a single dose without the need for repeated administration. The advantage of vaccines based on viral vectors is that they effectively induce cytotoxic T-cell immunity and also produce antibodies based on the structure of the virus. Many viruses are being studied as vectors for gene delivery, among which adenovirus is widely used in the field of gene therapy because it is easily controlled and its safety has been confirmed by many studies. Adenovirus is highly competitive with other viral vectors because it can deliver relatively large antigens (9-35 kb).

Adenovirus is a linear, double-stranded DNA virus with a diameter of 70-90 nm without an envelope, having an icosahedral capsid formed by 240 hexons, 12 pentons and fibrils (fibers) extending from each vertex of the icosahedron. These hexons, pentons and fibrils determine the main antigen of the adenovirus and its serotype. The adenovirus genome size is approximately 30-45 kb. and has 4 early regions (E1, E2, E3 and E4) and 5 late regions (L1-L5). Adenovirus is a good candidate as a recombinant vector for vaccine production because it is highly infectious and many adenoviruses are non-pathogenic. In addition, adenoviral vectors are capable of efficiently translating large genes and prolonging the immune response in animals. The adenoviral vector is mainly used in the form with the deleted E1 gene responsible for self-replication, while the adenoviral vector with the deleted E1 gene is safe because it does not exhibit pathogenicity in the body due to the inability to self-replicate in human cells.

The Ad5/35 vector is a form in which the knob gene of non-replicating adenovirus serotype 5 (Ad5) is replaced by the knob gene of adenovirus serotype 35 (Ad35). With this modification, the Ad5/35 vector can be introduced into cells through the CD46 receptor, which is highly expressed in human immune cells, rather than through the existing cellular Ad5 receptor. In other words, Ad5/35 is efficiently introduced into human antigen presenting cells and thus may be an effective vaccine platform for maximizing antigen production. In addition, there are reports that the Ad5/35 vector has a significantly lower risk of inducing hepatotoxicity compared to the Ad5 vector. In fact, the present inventors have confirmed in preclinical and clinical trials that when a cancer antigen gene is delivered to a cancer patient using an adenoviral vector, a high level of immune response is induced. In addition, clinical trials have confirmed that there are no stability or toxicity issues when administered to a large number of patients.

When preparing vaccine candidates, the stability of the expressed antigen must be taken into account. It should be noted that despite the secretion of large quantities of vaccine antigens, even if they are expressed, but are rapidly degraded in the early stages, they are not able to effectively activate immune cells. Therefore, it is important to maintain the antigen stably over a long period of time.

Therefore, to develop a vaccine for the prevention or treatment of coronavirus disease-19 (COVID-19), the present inventors prepared a preventive or therapeutic vaccine by introducing into a vector a polynucleotide in which the cleavage site located between the S1 gene and the S2 gene encoding the spike protein, which plays key role in infection of cells by SARS-CoV-2, replaced by a linker sequence. Moreover, in support of the present invention, the authors showed that the vaccine induces a high level of antibody production and ensures T-cell reactivity against SARS-CoV-2.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a new recombinant coronavirus spike protein, a polynucleotide encoding it, a vector containing the polynucleotide, and a vaccine for the prevention or treatment of coronavirus infection containing the vector.

To achieve the above object, the present invention provides a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The present invention also provides a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

The present invention also relates to a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The present invention also relates to a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vector containing a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vector containing a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vector characterized by introducing into an adenovirus a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vector characterized by introducing into the Ad5/35 virus a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vector characterized by introducing into the Ad5/35 virus a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vaccine for the prevention or treatment of coronavirus infection, comprising a vector containing a polynucleotide of the S1 and S2 genes of the coronavirus spike protein.

The present invention also relates to a vaccine for the prevention or treatment of coronavirus infection, containing a vector containing a polynucleotide of the S1 and S2 genes of the SARS-CoV-2 spike protein.

The present invention also relates to a vaccine for the prevention or treatment of coronavirus infection, characterized by the introduction of the polynucleotide of the S1 and S2 genes of the SARS-CoV-2 spike protein into the adenovirus.

The present invention also relates to a vaccine for the prevention or treatment of coronavirus infection, characterized by the introduction of the S1 and S2 polynucleotide of the SARS-CoV-2 spike protein into the Ad5/35 virus.

In addition, the present invention relates to a vaccine for the prevention or treatment of coronavirus disease-19 (COVID-19), containing a vector characterized by introducing into the Ad5/35 virus a polynucleotide in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein removed and a linker sequence introduced.

ADVANTAGE OF THE INVENTION

The present invention relates to a new recombinant coronavirus spike protein, a polynucleotide encoding it, a vector containing the polynucleotide, and a vaccine for the prevention or treatment of coronavirus infection containing the vector. The recombinant coronavirus spike protein of the present invention is stable and therefore does not rapidly degrade in cells. It effectively activates immune cells, thus ensuring high levels of antibody production and T-cell reactivity. The vector of the present invention has been confirmed to provide high levels of antigen expression and thus high levels of antibody production and T cell reactivity, have long periods of antibody production and expression, and are not hepatotoxic. Accordingly, the vector of the present invention can be successfully used as a vaccine for the prevention or treatment of coronavirus infection.

BRIEF DESCRIPTION OF THE DRAWINGS

Fig. 1 is a schematic diagram showing a vaccine for the prevention or treatment of COVID-19 according to the present invention, in which the E3 gene region, the receptor binding site, is replaced by the adenovirus serotype 35 fibril gene based on adenovirus serotype 5, and spike is introduced as an antigen. a protein that plays a key role in the infection of cells by SARS-CoV-2.

Fig. 2 is a schematic diagram showing a vaccine for the prevention or treatment of COVID-19 of the present invention containing a recombinant spike protein in which a cleavage site of a gene encoding the spike protein is replaced by a linker sequence so that the antigen has high structural stability, ensuring high expression of the antigen, where the antigen also has a superior ability to produce neutralizing antibodies in antibody-producing B cells.

Fig. 3 is a schematic diagram showing the working mechanism of a vaccine for preventing or treating coronavirus disease-19 according to the present invention.

Fig. 4 is a schematic diagram showing a control expression vector produced using the adenovirus type 5 (Ad5) genome.

Fig. 5 is a schematic diagram showing adenoviral vectors 1-4 loaded with spike protein antigens, which are antigen expression genes.

Fig. 6 is a graph showing the expression levels of antigens when adenoviral vectors 1-4 loaded with spike protein antigens, which are antigen expression genes, are introduced into a cultured cell line.

Fig. 7 is a graph showing the expression levels of antigens released from cells when adenoviral vectors 1-4 loaded with spike protein antigens, which are antigen expression genes, are introduced into a cultured cell line.

Fig. 8 is a graph showing the level of antibody production following injection of adenoviral vectors 1-4 loaded with spike protein antigens, which are antigen expression genes, into mice.

Fig. 9 is a graph showing the amount of antigen-specific antibodies present in the blood after mice are injected with adenoviral vector 3 loaded with spike protein antigens, which are antigen expression genes.

Fig. 10 is a graph showing the amount of antigen-specific antibodies present in the blood after monkeys are injected with adenoviral vector 3 loaded with spike protein antigens, which are antigen expression genes.

Fig. 11 is a graph showing the concentration of neutralizing antibodies after monkeys are injected with adenoviral vector 3 loaded with spike protein antigens, which are antigen expression genes.

Fig. 12 is a graph showing hepatotoxicity levels in the blood after monkeys were injected with adenoviral vectors 1-4 loaded with spike protein antigens, which are antigen expression genes.

Fig. 13 is a graph showing T cell reactivity in spleen cells and peripheral blood mononuclear cells (PBMCs) following injection of mice with adenoviral vectors 1-3 loaded with spike protein antigens, which are antigen expression genes.

Fig. 14 is a graph showing T cell reactivity in peripheral blood mononuclear cells (PBMCs) following injection of adenoviral vector 3 loaded with spike protein antigens, which are antigen expression genes, in primates.

Fig. 15 is a graph confirming that when mice are injected with the viral genome, vector 3 expressing the spike protein antigens produced in Example 3 or a vector in which, among the adenoviral genes of vector 3, the E4 gene is rearranged into the E1 region, produce similar levels of neutralizing antibodies.

Fig. 16 is a graph confirming that when the viral genome is administered to monkeys, vector 3 expressing the spike protein antigens obtained in Example 3 or a vector in which, among the adenoviral genes of vector 3, the E4 gene is rearranged into the E1 region, produce similar levels of neutralizing antibodies.

DESCRIPTION OF PREFERRED IMPLEMENTATION OPTIONS

The following is a more detailed description of the present invention.

The present invention relates to a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

This coronavirus is characterized by the fact that it is SARS-CoV, MERS-CoV or SARS-CoV-2, related to beta coronaviruses.

The genome homology between SARS-CoV-2 and SARS-CoV is 79.6%, and the genome homology between SARS-CoV-2 and MERS-CoV reaches 50%. In particular, although the homology of the spike protein, which is the object of the present invention, between SARS-CoV-2 and MERS-CoV is as high as 35%, the homology of the spike protein between SARS-CoV-2 and SARS-CoV is very high at 76%.

The present invention also provides a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

In the production of vaccines, it is important that antigens are secreted in large quantities, but even if they are expressed in large quantities and are immediately broken down, they do not stimulate immune cells sufficiently to induce an immune response, so it is very important that the expressed antigen has high stability . The recombinant spike protein of the present invention, in which the linker sequence is linked to S1 and S2, has high antigen expression and improved stability, and thus has excellent ability to generate neutralizing antibodies and induce T cell reactivity.

The term "immune response" may include humoral and cellular immune responses, such as, without limitation, activation of CD4+ or CD8+ cells.

A spike protein antigen linked by a linker sequence is characterized by increased antigen expression.

Spike protein (S protein) coats the surface of the coronavirus particle. It is a spike protein used by coronavirus to enter human cells and is composed of S1 and S2 subunits. When the human body is infected, the coronavirus spike protein binds to the angiotensin-converting enzyme 2 (ACE-2) receptor of human cells, enters the cells, inserts its genetic material (RNA) into the cells, and reproduces itself.

The recombinant protein is characterized by the removal of the cleavage site between the S1 and S2 genes, which are subunits of the spike protein.

The protein is characterized by removing the cleavage site between the S1 and S2 genes and connecting them with a linker sequence.

The linker is different in that it consists of (GGGGS)n, where n is an integer from 1 to 5.

The distance (linker sequence length) between the domains that make up each protein is optimized for interaction according to their unique characteristics, and the structural stability of the protein is determined by the length of the linker sequence. Therefore, the n of the protein can preferably be from 1 to 3, and most preferably 1.

When n exceeds 4, a large number of repeated sequences are created, and the linker sequence may be removed by unintentional homologous recombination and protein stability will decrease.

The spike protein antigen linked by a linker sequence is characterized by increased stability.

The linker sequence is characterized as consisting of SEQ ID NO: 19 or SEQ ID NO: 20.

All coronaviruses share a common spike protein, which consists of S1 and S2 subunits, so all coronavirus spike proteins can be used.

All spike proteins in which the cleavage site between the S1 and S2 genes of the spike protein are removed and the genes are linked by a linker are within the scope of the present invention.

Coronaviruses include 229E, OC43, NL63 and HKU1, which cause the common cold, and SARS-CoV, MERS-CoV and SARS-CoV-2, which cause severe pneumonia. All the spike proteins of these coronaviruses can be used.

Preferably, the spike protein is a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

The recombinant spike protein may further contain an adjuvant to enhance immunogenicity. The adjuvant may be at least one selected from the group consisting of GM-CSF, IL-17, IFNNg, IL-15, IL-5, JNK, NFkB, NKKKKLIGAND, PD1/2, NKKKKG2B, NKG2C, NKKKKG2E, NKKKK2F, TAPAPAP2 and its functional fragment, E-selectin, IL-α, IL-6, INF-γ, lymphotoxin α, hGH-1, MIPPP1, IL-7, IL-8, APP, IRARAK, IkB, KILILUX, TRAIL-1 , IL-1, AIR and ICAM-1, ICAM-1, TAP2, functional fragment CD40, TAP1, TRAILrecDRC5, CD34, CD40L, DR3, GlyCAM1, p55, CD2, Ox40, TRAF6, DR4, ICAM3, DR5, MyD88, p65Rel , pl5095, p38, CPG and TLR.

The adjuvant may be linked to the C-terminus of the recombinant spike protein.

The present invention also relates to a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

A coronavirus is characterized by being SARS-CoV, MERS-CoV or SARS-CoV-2.

The present invention also relates to a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

The linker is characterized in that it consists of 9-45 nucleotides, preferably 9-21 nucleotides and more preferably 15 nucleotides.

A polynucleotide encoding a spike protein linked by a linker sequence is characterized by increased stability.

A polynucleotide encoding a spike protein linked by a linker sequence is characterized by increased antigen expression.

The linker sequence is characterized as consisting of SEQ ID NO: 11 or SEQ ID NO: 15.

The polynucleotide may have SEQ ID NO: 12 or 16.

The present invention also relates to a vector containing a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

A coronavirus is characterized by being SARS-CoV, MERS-CoV or SARS-CoV-2.

The present invention also relates to a vector containing a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vector characterized by the introduction into an adenovirus of a polynucleotide encoding a recombinant spike protein, in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vector characterized by the introduction into an adenovirus of a polynucleotide encoding a recombinant spike protein, in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

A vector obtained by introducing into an adenovirus a polynucleotide encoding a recombinant spike protein, in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced, may have SEQ ID NO: 27 or 29.

The present invention also relates to a vector characterized by introducing into the Ad5/35 virus a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced.

The present invention also relates to a vector characterized by introducing into the Ad5/35 virus a polynucleotide encoding a recombinant spike protein in which the cleavage site between the S1 and S2 genes of the SARS-CoV-2 spike protein is removed and a linker sequence is introduced.

In the present invention, the term “vector” means a transporter that carries cloned genes (or other fragments of cloned DNA) and transports them to target cells.

The vector can be any selected from the group consisting of plasmids and viruses.

Specific examples of plasmid DNA include commercial plasmids such as pCMV3, pET28a and pET. Other examples of plasmids that can be used in the present invention include plasmids derived from Escherichia coli (pCMV3, pET28a, pET, pGEX, pQE, pDEST and pCOLD), plasmids derived from Bacillus subtilis (pUB110 and pTP5), and plasmids derived from from yeast (YEp13, YEp24 and YCp50). Since these plasmids exhibit varying degrees of protein expression and modification depending on the host cell, the host cell most suitable for the purpose can be selected and used.

The virus may be any known virus that can be used as a vector, and may be any virus selected from the group consisting of, but not limited to, adenovirus, retrovirus, lentivirus, adeno-associated virus (AAV), modified vaccinia virus (MVA), herpes simplex virus and baculovirus. According to a particular embodiment of the present invention, it is preferred that the virus is an adenovirus.

As used herein, the term “adenoviral vector” refers to an adenovirus that has been modified so that the nucleic acid sequence of the adenovirus genome is not native to the adenovirus genome. Therefore, a “recombinant adenovirus vector” as used herein typically comprises an expression cassette containing at least one foreign nucleic acid sequence encoding an adenovirus genome and a desired protein (e.g., a recombinant spike protein in which the cleavage site between S1 and S2 of the spike SARS-CoV-2 protein is replaced by a linker sequence).

The adenoviral vector preferably contains at least a portion of each terminal repeat sequence necessary to support viral DNA replication, preferably at least about 90% inverted terminal repeat (ITR) sequence, and DNA necessary to encapsulate the genome into the viral capsid. Adenoviruses of various origins can be used as a source of the viral genome for adenoviral vectors. Preferred human adenoviruses are subgroup A (eg, serotypes 12, 18, and 31), subgroup B (eg, serotypes 3, 7, 11, 14, etc.), subgroup C (eg, serotypes 1, 2, 5 and 6), subgroup D (for example, serotypes 8, 9, 10, 13, 15, 17, 19, 20, etc.), subgroup E (for example, serotype 4), subgroup F (for example, serotypes 40 and 41) and others. The adenoviral vector is preferably a human subgroup C vector, in particular serotype 2, and more preferably serotype 5.

The adenoviral vector may be a replication competent vector. Typically, an adenoviral vector is a vector that is defective in replication in host cells. The term “replication defective” means an adenoviral vector that is deficient in one or more functions or gene regions (e.g., the E1, E3, or E4 region) of the adenoviral genome required for replication, such that the vector maintains some low level of replication or does not replicate in normal cells -hosts, especially in human cells infected with an adenoviral vector. A replication-defective adenoviral vector guarantees the safety of vaccines. In one embodiment of the present invention, the adenoviral vector is a vector in which the E1 or E3 region, or both, has been deleted. A gene deficiency is defined as a mutation or deletion resulting in complete loss or impairment of gene function, such as one in which the function of the gene product is reduced by at least about 2-fold, 5-fold, 10-fold, 20-fold or more than the naturally occurring gene. The resulting replication-defective adenoviral vector is capable of housing one or more exogenous nucleic acid sequences at appropriate sites in the adenovirus genome for expression of one or more desired proteins while retaining the ability to be packaged into the adenovirus capsid. To obtain high titers of viral vectors for stock solutions, the replication-defective adenoviral vector is typically produced in complementary cell lines, such as HEK293 or HEK293R cells, which provide gene functions not present in the replication-defective adenoviral vector.

The adenovirus may be adenovirus serotype 2 (Ad2), adenovirus serotype 4 (Ad4), adenovirus serotype 5 (Ad5), adenovirus serotype 11 (Ad11), adenovirus serotype 26 (Ad26), adenovirus serotype 35 (Ad35), chimpanzee adenovirus serotype 68 (ChAd68), chicken adenovirus serotype 9 (FAd9) or porcine adenovirus serotype 3 (PAd3).

The adenovirus may have a modified form based on Ad5.

The adenovirus may be an adenovirus (Ad5/35) in which the knob gene of adenovirus serotype 5 (Ad5) has been replaced by the knob gene of adenovirus serotype 35 (Ad35).

The adenovirus is characterized by the fact that the E1 gene and the E3 gene are deleted.

The adenovirus may be in a form in which the E4 gene is partially or completely removed and the E4 gene is moved to the E1 region in addition to the removal of the E1 gene and the E3 gene.

The adenovirus is characterized in that it is introduced into cells through the CD46 receptor, which is highly expressed in human immune cells.

Adenovirus is characterized by a low effect of inducing hepatotoxicity.

Adenovirus is characterized by a high degree of antigen expression.

The present invention also relates to a vaccine for the prevention or treatment of coronavirus infection, comprising a vector containing a polynucleotide of the S1 and S2 genes of the coronavirus spike protein.

The coronavirus can be any one selected from the group consisting of SARS-CoV, MERS-CoV and SARS-CoV-2.

The vector may be any known virus that can be used as a vector, and may be any virus selected from the group consisting of, but not limited to, adenovirus, retrovirus, lentivirus, adeno-associated virus (AAV), and modified vaccinia virus (MVA). According to a particular embodiment of the present invention, it is preferred that the virus is an adenovirus.

The adenovirus may be adenovirus serotype 2 (Ad2), adenovirus serotype 4 (Ad4), adenovirus serotype 5 (Ad5), adenovirus serotype 11 (Ad11), adenovirus serotype 26 (Ad26), adenovirus serotype 35 (Ad35), chimpanzee adenovirus serotype 68 (ChAd68), chicken adenovirus serotype 9 (FAd9) or porcine adenovirus serotype 3 (PAd3).

The adenovirus may have a modified form based on Ad5.

The adenovirus may be an adenovirus (Ad5/35) in which the knob gene of adenovirus serotype 5 (Ad5) has been replaced by the knob gene of adenovirus serotype 35 (Ad35).

The adenovirus is characterized by the fact that the E1 gene and the E3 gene are deleted.

The adenovirus may be in a form in which the E4 gene is partially or completely removed and the E4 gene is moved to the E1 region in addition to the removal of the E1 gene and the E3 gene.

The adenovirus is characterized in that it is introduced into cells through the CD46 receptor, which is highly expressed in human immune cells.

The present invention also relates to a vaccine for the prevention or treatment of coronavirus infection, containing a vector containing a polynucleotide of the S1 and S2 genes of the SARS-CoV-2 spike protein.

The present invention also relates to a vaccine for the prevention or treatment of coronavirus infection, characterized by the introduction of the polynucleotide of the S1 and S2 genes of the SARS-CoV-2 spike protein into the adenovirus.

The present invention also relates to a vaccine for the prevention or treatment of coronavirus infection, characterized by the introduction of the S1 and S2 polynucleotide of the SARS-CoV-2 spike protein into the Ad5/35 virus.

Moreover, the vaccine of the present invention can be formulated as an oral or parenteral preparation and can be administered intradermally, intramuscularly or intranasally, preferably intramuscularly.

The vaccine of the present invention is characterized in that the cleavage site between S1 and S2 is removed.

The vaccine is characterized in that the cleavage site between S1 and S2 of the spike protein is removed and S1 and S2 are linked by a linker sequence.

The linker is characterized in that it consists of 9-45 nucleotides, preferably 9-21 nucleotides and more preferably 15 nucleotides.

In addition, the present invention provides a method for preventing or treating a coronavirus infection, including coronavirus disease-19, severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS), by administering a vaccine to a subject.

In the present invention, the term "subject" means all animals, including humans, that can be infected with coronavirus. The above diseases can be effectively prevented by administering the vaccine of the present invention to the subject. For example, the vaccine of the present invention can protect people from coronavirus.

In the present invention, the term "prevention" means any action that suppresses or delays the onset of coronavirus infection by administering a vaccine.

In the present invention, the term "treatment" means any action that removes the coronavirus or alleviates the symptoms caused by the coronavirus by administering a vaccine.

The vaccine of the present invention is administered in a pharmaceutically effective dose. The term "pharmaceutically effective dose" means an amount sufficient to treat a disease with a reasonable benefit/risk ratio applicable to drug treatment or enhancement. The effective dose level depends on factors such as the type and severity of the disease, age, sex, type of virus infected, drug activity, drug sensitivity, time of administration, route of administration, rate of elimination, duration of treatment, concomitant medications and other factors well known in the literature. field of medicine. The vaccine of the present invention can be administered alone or in combination with other therapeutic agents. For combined administration, administration may be sequential or simultaneous. The vaccine can be administered once or multiple times. It is important that the amount administered can provide maximum effect in a minimum amount without causing side effects, taking into account all the above factors, which can be easily determined by those skilled in the art.

The term "effective amount" refers to a dose sufficient to provide the desired therapeutic effect in the subject being treated, for example, sufficient to generate or induce an immune response against a pathogen or antigen at its receptor. The effective amount may vary depending on various reasons, such as the route of administration, frequency of administration, body weight and type of the individual receiving the drug, and the purpose of administration. Those skilled in the art can determine the dosage in each case based on the disclosure, conventional techniques, and their own experience. For example, in a certain embodiment of the present invention, the recombinant adenoviral vector of the present invention can be administered at a dose of 1×10 ⁹ to 1×10 ¹² viral particles (VP), for example, can be administered at a dose of 1×10 ⁹ , 1×10 ¹⁰ , 1×10 ¹¹ or 1×10 ¹² HF.

In a specific embodiment of the present invention, the present inventors constructed a vector by introducing a polynucleotide in which the cleavage site between S1 and S2 of the polynucleotide encoding the spike protein of SARS-CoV-2 related to coronavirus is replaced by a linker sequence into an adenovirus in which the E1 genes have been deleted both E3 and the fibril, which is the binding site for the cellular receptor of adenovirus serotype 5, is replaced by a serotype 35 fibril (see Fig. 4); it is confirmed that the vector provides high levels of antigen expression and antibody production and T-cell reactivity, has long periods of antibody expression and production and does not cause hepatotoxicity (see Figs. 6, 7, 9, 12, 13 and 14). In addition, a vaccine prepared by loading an antigen into a vector in which the E4 gene is partially or completely removed and the E4 gene is moved to the E1 region in addition to the removal of the E1 gene and the E3 gene was administered to mice and monkeys. As a result, it was confirmed that the amount of neutralizing antibodies produced was similar to that of the vaccine obtained by loading the antigen into the Ad5/35 vector (see FIGS. 15 and 16).

The recombinant coronavirus spike protein of the present invention is stable and therefore not rapidly degraded in cells, and effectively activates immune cells, resulting in high levels of antibody production and T cell reactivity. The vector of the present invention has been confirmed to provide high levels of antigen expression and therefore high levels of antibody production and T cell reactivity, have long periods of antibody production and expression, and are not hepatotoxic. Accordingly, the vector of the present invention can be successfully used as a vaccine for the prevention or treatment of coronavirus infection.

The present invention will now be described in more detail with reference to the following examples and experimental examples.

However, the following examples and experimental examples are intended only to illustrate the present invention, and the content of the present invention is not limited to them.

<Example 1> Construction of a control expression vector (plasmid vector 1)

A plasmid named pAdk35F (SEQ ID NO: 1, 34030 bp) containing the adenovirus sequence (SEQ ID NO: 21) lacking the antigen, the spike protein, was constructed using the genome of adenovirus type 5 (Ad5). pAdk35F included an adenovirus with the E1 and E3 genes deleted and a fibril representing the binding site for the cellular receptor of adenovirus serotype 5, replaced by a fibril of serotype 35. The deletion site of the E1 gene pAdk35F was loaded with the CMV (cytomegalovirus) promoter, tetracycline operator (Tet O), SwaI restriction enzyme site and the poly-A sequence of SV40.

As shown in FIG. 4, the extracellular domain of the antigen spike protein gene was amplified using the spike protein antigen amplification primer set listed in Table 1 below using the vector pCMV3-SARS-CoV-2 (Spike ORF) (Sino Biological, catalog number: VG40589 -UT, SEQ ID NO: 2, 9858 bp) loaded with a polynucleotide encoding the spike protein, antigen expression gene, as a template, and then plasmid vector 1 (SEQ ID NO: 22), a control expression vector, was constructed by ligation for fusion cloning (Clontech, catalog number: 639648) with SwaI-digested pAdk35F vector. The region encoding the spike protein in plasmid vector 1 is shown in SEQ ID NO: 3, and the nucleotide sequence of the adenovirus into which the spike protein is introduced is shown in SEQ ID NO: 23.

Table 1 Sequence (5'→3') SEQ ID NO Direct primer TCC AGC CTC CGA TTT GCC ACC ATG TTT GTG TTC CTG G 4 Reverse primer GAT TAT GAT CAA TTT TCA TGG CCA CTT GAT GTA TTG TTC 5

As shown in FIG. 4, the extracellular domain of the antigen spike protein gene was amplified using the spike protein antigen amplification primer set shown in Table 1 using the vector pCMV3-SARS-CoV-2 (Spike ORF) (Sino Biological, catalog number: VG40589- UT, SEQ ID NO: 2, 9858 bp), loaded with a polynucleotide encoding the spike protein, antigen expression gene, as a template, and then constructed plasmid vector 1 (SEQ ID NO: 22), a control expression vector, by ligation for infusion cloning (Clontech, catalog number: 639648) with SwaI-digested pAdk35F vector. The region encoding the spike protein in plasmid vector 1 is shown in SEQ ID NO: 3, and the nucleotide sequence of the adenovirus into which the spike protein is introduced is shown in SEQ ID NO: 23.

<Example 2> Construction of an improved spike antigen expression vector

<2-1> Construction of an improved spike antigen expression vector (plasmid vector 2)

The cleavage site (SEQ ID NO: 6, amino acid sequence: TNSPRRAR) of the S1 and S2 domains of the antigen, spike protein, vector pCMV3-SARS-CoV-2 (Spike ORF), used as a template for the polymerase chain reaction in Example 1, was replaced by the sequence TILR (Thr-Ile-Arg-Leu) (SEQ ID NO: 7) using the primer set shown in Table 2 below by site-directed mutagenesis to obtain the vector pCMV3-SARS-CoV-2 (Spike IL) as shown in fig. 5.

The TILR sequence-replaced vector was then amplified using the same spike antigen amplification primer set listed in Table 1 as plasmid vector 1, and then plasmid vector 2 (SEQ ID NO: 24), an improved spike antigen expression vector, was constructed. , by ligation for infusion cloning (Clontech, catalog number: 639648) with the SwaI-digested pAdk35F vector. The region encoding the spike protein in plasmid vector 2 is shown in SEQ ID NO: 8, and the nucleotide sequence of the adenovirus into which the spike protein is introduced is shown in SEQ ID NO: 25.

table 2 Sequence (5'→3') SEQ. ID. NO Direct primer AGA CCA TCC TCA GGT CTG TGG CAA GCC AGA G 9 Reverse primer CCT CCT ACC AGA CCC AGA CCA TCC TCA GGT 10

<2-2> Creating a design improved spike antigen expression vector (plasmid vector 3; pAdCLD-CoV19 vector)

The cleavage site (SEQ ID NO: 6, amino acid sequence: TNSPRRAR) of the S1 and S2 domains of the antigen, spike protein, vector pCMV3-SARS-CoV-2 (Spike ORF), used as a template for the polymerase chain reaction in example 1, was replaced by a linker sequence TGGGGSR (SEQ ID NO: 11) using the primer set shown in Table 3 below, by site-directed mutagenesis to obtain the vector pCMV3-SARS-CoV-2 (Spike GGGGS). The TGGGGSR sequence substitution vector was then amplified using the same set of spike antigen amplification primers listed in Table 1 as plasmid vector 1, and then plasmid vector 3 (pAdCLD-CoV19 vector) was constructed (SEQ ID NO: 26) , an improved spike antigen expression vector, by ligation for fusion cloning (Clontech, catalog number: 639648) with the SwaI-digested pAdk35F vector. The region encoding the spike protein in plasmid vector 3 is shown in SEQ ID NO: 12, and the nucleotide sequence of the adenovirus into which the spike protein is introduced is shown in SEQ ID NO: 27.

Table 3 Sequence (5'→3') SEQ. ID. NO Direct primer CGG TGG CGG TGG GTC GAG GTC TGT GGC AAG CCA GAG 13 Reverse primer GAC CCA CCG CCA CCG GTC TGG GTC TGG TAG GAG G 14

<2-3> Creating a structure improved spike antigen expression vector (plasmid vector 4)

The cleavage site (amino acid sequence: TNSPRRAR) of the S1 and S2 domains of the antigen spike protein vector pCMV3-SARS-CoV-2 (Spike ORF) used as a template for the polymerase chain reaction in Example 1 was replaced with the sequence TGGGGSGGGGSGGGGSR (SEQ ID NO: 15) using the set of primers shown in Table 4 below, by site-directed mutagenesis to obtain the vector pCMV3-SARS-CoV-2 (Spike GGGGSx3). The sequence substitution vector TGGGGSGGGGSGGGGSR was then amplified using the same set of spike antigen amplification primers as plasmid vector 1, and then plasmid vector 4 (SEQ ID NO: 28), an improved spike antigen expression vector, was constructed by ligation for cloning method fusions (Clontech, catalog number: 639648) with SwaI-digested pAdk35F vector. The region encoding the spike protein in plasmid vector 4 is shown in SEQ ID NO: 16, and the nucleotide sequence of the adenovirus into which the spike protein is introduced is shown in SEQ ID NO: 29.

Table 4 Sequence (5'→3') SEQ. ID. NO Direct primer GGG CGG TGG TGG GTC GGG TGG CGG CGG TTC CAG GTC TGT GGC AAG CCA GAG 17 Reverse primer GAC CCA CCA CCG CCC GAC CCA CCG CCA CCG GTC TGG GTC TGG TAG GAG G 18

<Example 3> Creation of adenoviral vector constructs loaded with spike antigens (vectors 1-4)

Adenoviral vectors (vectors 1-4) were prepared from the vectors of Examples 1 and 2 described above (plasmid vectors 1-4) using HEK293R cells. Stock adenoviral vectors were prepared by transfecting approximately 80% confluent HEK293R cells on T25 plates with 12.5 μg of each vector along with 25 μl of Lipofectamine 2000 (ThermoFisher, catalog number: 11668027). Each initially produced adenovirus was amplified by infecting 20 T175 flasks containing 4×10 ⁷ HEK293R cells.

Amplified adenoviral vectors 1-4 were purified using the first (1.2 g/ml CsCl + 1.4 g/ml CsCl, 32000 rpm, 90 minutes) and the second (1.35 g/ml CsCl, 32000 rpm , 18 hours) cesium chloride (CsCl) density gradient centrifugation steps. The final adenoviruses were obtained by dialysis (20 mM Tris-HCl, 25 mM sodium chloride, 2.5% glycerol).

<Example 4> Comparison of antigen expression levels of antigen expression vectors in vitro

<4-1> Comparison of intracellular antigen expression depending on the injection of antigen expression vectors

To compare the levels of intracellular antigen expression of vectors 1-4 obtained in Example 3, the level of antigen expression in the THP-1 cell line derived from mononuclear cells was measured using flow cytometry (FACS).

Specifically, for flow cytometry, THP-1 cells were plated in a 96-well culture dish at a density of 2.5 x 10 ⁵ cells per well, and each vector was inoculated into the cells at a multiplicity of infection (MOI) of 10, followed by culturing for 24 hours. The cells in each well were then transferred to a 1.5 mL tube, 500 μL of FACS buffer was added, and centrifuged (5000 rpm, 3 minutes, 4°C). After removing the supernatant, 50 μl of viability indicator dye (eFluor™450, Ebioscience, catalog number: 65-0863-14) diluted 1:1000 was added to each well and surface staining was performed at 4°C for 30 minutes.

To detect antigens expressed within cells, cell fixation/permeabilization concentrate (Ebioscience, catalog number: 00-5123-43) was diluted 1:4 in cell fixation/permeabilization diluents (Ebioscience, catalog number: 00-5223-56 ), and 100 μl of solution was added to each well, followed by cell fixation/permeabilization at 4°C for 30 minutes. Spike antigen staining was performed using a solution (antibody concentration: 0.4 μg/ml) of anti-SARS-CoV-2 spike protein antibody (GeneTex, cat. no. GTX632604) diluted 1:2500 in permeabilization buffer (Ebioscience, cat. no. : 00-8333-56) at 4°C for 1 hour followed by washing, and then antigen staining was performed (4°C, 30 minutes) with a solution (antibody concentration: 2 μg/ml) of goat anti-mouse IgG antibody APC (Biolegend , catalog number 405308), secondary antibody diluted 1:100. After the staining reaction, 300 μl of buffer per sample was added, and the degree of antigen expression was measured using flow cytometry (BD bioscience, LSRFORESSA).

As a result, as shown in FIG. 6, it was confirmed that the highest level of antigen expression, i.e. the ability to produce protein was demonstrated by adenoviral vector 3, obtained in example 3.

<4-2> Comparison of extracellular antigen expression depending on the injection of antigen expression vectors

To compare the expression levels of extracellular antigens of vectors 1-4 obtained in Example 3, the antigen expression levels in mononuclear cell-derived THP-1 cells and muscle cell-derived RD cells were measured by Western blotting.

Specifically, the Western blot method for measuring the expression level of antigen, the spike protein, released from cells was as follows. THP-1 and RD cells were distributed into 6-well culture dishes at a density of 5×10 ⁵ cells per well, and the cells were then inoculated with each vector at an MOI of 50, followed by culturing for 24 hours. Thereafter, the culture medium was collected by centrifugation, and then the culture medium was concentrated using Microcon (Millipore, 50000 MWCO, catalog number: UFC805024), and the cultured cells were digested into protein units using RIPA buffer (ThermoFisher, catalog number: 89901). The total amount of protein in the concentrated culture medium was measured using a BCA protein assay kit (Thermo Fisher, part number: 23225).

To confirm the presence of spike protein (trimer, approximately 250 kDa or greater) in a sample of concentrated culture medium, the sample (60 μg/well) was subjected to electrophoresis at 180 V using Bolt™ Bis-Tris 4-12% plus gel (ThermoFisher, part no. catalogue: NW04120BOX).

After electrophoresis, the gel was transferred to a PVDF membrane for 10 minutes at 20 V using an iBlot 2 dry blotting system (Invitrogen, catalog number: IB21001). The membrane was then reacted with rabbit anti-SARS-CoV-2 spike protein antibody (GeneTex, catalog number: GTX135360) and goat anti-rabbit IgG H&L (HRP), respectively, and the trimeric SARS-CoV-2 spike protein was detected using the reagent for detection of ECL Prime by Western blotting (Amersham, catalog number: RPN2232).

As a result, as shown in FIG. 7, it was confirmed that adenoviral vector 3 obtained in Example 3 had the highest level of antigen expression for protein generation and release.

<Example 5> Comparison of the level of antibody production in mice depending on the injection of antigen expression vectors

<5-1> Comparison of the level of antibody production in mice depending on the injection of antigen expression vectors 1-4

Levels of antibody production were compared after administration of vectors 1-4 obtained in example 3 to mice.

Specifically, the spike antigen expression vectors obtained in Example 3 (vectors 1-4) were injected intramuscularly into 6-7 week old BALB/c mice at a dose of 2×10 ⁸ IFU/mouse, 6 mice per group. Approximately 300 μl of blood sample was collected by drawing blood from the orbital vein 2-3 weeks after administration. Plasma was then separated by centrifugation (8000 rpm, 10 minutes, 20°C), and the amount of neutralizing antibodies present in the blood was determined using an enzyme-linked immunosorbent assay (ELISA).

For enzyme-linked immunosorbent assay, a 96-well plate was coated with spike protein (Acro Biosystems, catalog number: SPN-C52H84) dissolved in PBSN (1 L PBS + 0.01 g sodium azide) at a concentration of 100 ng/well, followed by reaction with cold at 4°C for 16 hours. After coating the 96-well plate for 16 hours, the coating protein was removed, washed three times with PBS, and then 150 μl of blocking buffer (PBSN+BSA 1%) was added to each well, followed by reaction (37°C, 90 minutes). During the reaction, the plasma was diluted 6400 times in dilution buffer (PBSN+0.1% BSA+0.05% Tween-20), and after the blocking reaction, the plate was washed three times with PBS, and then 50 μl of the diluted plasma sample was added to each well. followed by reaction (37°C, 3 hours). Upon completion of the reaction, the plate was washed three times with PBS, and then 50 μl of secondary antibodies, GAM-IgG-HRP (Southernbiotech, catalog number: 1030-05) and GAM-IgM-HRP (Southernbiotech, catalog number: 1020) were added to each well. -05), diluted 1000 times with dilution buffer, followed by reaction (37°C, 2 hours). Secondary antibodies were then removed, the plate was washed 5 times with PBS, and 50 μl of chromogenic reagent (TMB Peroxidase substrate buffer, ROCKLAND, catalog number: TMBE-1000) was added to each well, followed by color development for 15 minutes. Color development was stopped by adding 50 μl of 0.25 N to each well. HCl and the sample was analyzed at 450 nm using a microreader.

As a result, as shown in FIG. 8, it was found that adenoviral vector 3 obtained in Example 3 had the highest level of antibody production.

<5-2> Comparison of periods of antibody expression and production in mice depending on the injection of antigen expression vectors

In addition, the adenoviral vectors obtained in example 3 (vectors 1-3) were injected intramuscularly into 8-week-old BALB/c mice at a dose of 1×10 ⁹ HF/mouse or 2×10 ⁸ HF/mouse, 6 mice per group. Approximately 300 μl of blood sample was collected by drawing blood from the orbital vein 2-4 weeks after administration. The plasma was then separated by centrifugation (8000 rpm, 10 minutes, 20°C) and the amount of antigen-specific antibodies present in the blood was measured using an enzyme-linked immunosorbent assay (ELISA) according to Example 5-1.

As a result, as shown in FIG. 9, it was found that the level of antigen-specific antibodies present in the blood of mice injected with adenoviral vector 3 prepared in Example 3 remained at a higher level than that of vector 2 for 4 weeks or longer.

<Example 6> Comparison of levels of antibody production and hepatotoxicity in monkeys depending on the injection of antigen expression vectors

<6-1> Comparison of levels of antibody production in monkeys as a function of injection of antigen expression vectors

Levels of antibody production in monkeys were compared after injection of adenoviral vectors (vectors 1 and 3) obtained in example 3.

In particular, adenoviral vectors 1 and 3 obtained in example 3 were injected intramuscularly into 6-7 week old monkeys (cynomolgus) at a dose of 1×10 ¹¹ HF/monkey, 2 monkeys per group. At 2 and 3 weeks after immunization, blood samples were collected from the monkeys by intravenous blood draw. The plasma was then separated by centrifugation (8000 rpm, 10 minutes, 20°C) and the amount of antibodies present in the blood was measured using an enzyme-linked immunosorbent assay (ELISA) and a pseudovirus neutralization assay.

For the enzyme-linked immunosorbent assay, a 96-well plate was coated with spike protein (Acro Biosystems, catalog number: SPN-C52H84) dissolved in PBSN at 100 ng/well, followed by a cold reaction at 4°C for 16 hours. After coating the 96-well plate for 16 hours, the coating protein was removed, washed three times with PBS, and then 150 μl of blocking buffer was added to each well, followed by reaction (37°C, 90 minutes). During the reaction, the plasma was diluted 1600-fold with dilution buffer, and after the blocking reaction, the plate was washed three times with PBS, and then 50 μl of the diluted plasma sample was added to each well, followed by reaction (37°C, 3 hours). Upon completion of the reaction, the plate was washed three times with PBS and 50 μl of secondary antibody, total human Ig-HRP (Southernbiotech, catalog number: 1010-05), diluted 1000 times in dilution buffer, was added to each well, followed by reaction (37°C , 2 hours). The secondary antibody was then removed, the plate was washed 5 times with PBS, and 50 μl of chromogenic reagent (TMB Peroxidase Substrate Buffer, ROCKLAND, Cat. No.: TMBE-1000) was added to each well, followed by color development for 15 minutes. Color development was stopped by adding 50 μl of 0.25 N to each well. HCl and the sample was analyzed at 450 nm using a microreader.

For the pseudovirus neutralization assay, the HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was plated in a 96-well plate at a density of 1 x 10 ⁴ cells/well and cultured for 10 hours (37°C, 5% CO ₂ ). Plasma collected from monkeys by intravenous sampling at 2 and 3 weeks after immunization was diluted 4-fold from 100 to 6400 times and reacted with 7 × 10 ⁵ U/ml pseudovirus (lentivirus expressing spike protein and luciferase) for 1 hour (37°C). Plasma was inoculated into a 96-well plate containing HEK293T-hACE2 cells, which were co-cultured with 2 μg/well (200 μl) polybrene (Merck, catalog number: TR-1003-G) for 2 days. The presence of neutralizing antibodies binding to the spike protein in plasma was then confirmed by measuring the level of luciferase protein expression induced by infection of the HEK293T-hACE2 cell line with the pseudovirus. Cells cultured for 2 days were washed with DPBS and then lysed with 25 μg of cell lysis reagent (Promega, catalog number: E153A). After transferring the lysed sample to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, catalog number: E151A) was added to each well and the luminescence level was measured (detection indicator injection - stirring for 5 seconds - 2 second delay - measurement for 10 seconds) using a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, catalog number: LB960, software: Mikro 2000 program).

As a result, as shown in FIG. 10, it was confirmed that upon injection of the vector, the level of antibody production is high and that the antibody titer is maintained even 5 weeks after injection of the vector. Moreover, as shown in FIG. 11, it was confirmed that when vector 3 was injected, the concentration of neutralizing antibodies was high. These results suggest that large amounts of neutralizing antibodies begin to be produced 2 weeks after vaccine administration, effectively blocking the virus from infecting cells.

<6-2> Comparison of hepatotoxicity in monkeys depending on injection of antigen expression vectors

By nature, most adenoviruses travel to the liver and cause hepatotoxicity. Since hepatotoxicity is fatal to the human body, it is very important to obtain a vaccine that does not exhibit hepatotoxicity even when a high dose of viral particles is administered. Accordingly, hepatotoxicity was compared in monkeys depending on the injection of adenoviral vectors (vectors 1 and 3) obtained in example 3.

Adenoviral vectors 1 and 3, prepared in example 3, were injected intramuscularly into 6-7-week-old monkeys (cynomolgus) at a dose of 1×10 ¹¹ HF/monkey, 2 monkeys per group. Blood was collected from all animals before (pre), as well as 9, 22 and 36 days after administration. All blood sampling was performed on an empty stomach (free drinking water), and approximately 3 ml of blood was collected from the femoral vein using a disposable syringe (3 ml, 23G, KOREAVACCINE, KOR).

Approximately 0.6 ml of blood collected for biochemical studies was added to an SST™ tube (Vacutainer®, BD, USA) and the serum was separated by centrifugation at 13,000 rpm for 5 minutes (5424R, Eppendorf, USA). Hepatotoxicity, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were then measured using a biochemical analyzer (7180, HITACHI, JPN).

As a result, as shown in FIG. 12, it was confirmed that monkeys injected with vectors 1 and 3 using the same adenoviral vector platform did not exhibit severe hepatotoxicity even when administered high doses of viral particles.

<Example 7> Measurement of T cell reactivity after injection of antigen expression vectors in mice and monkeys

<7-1> Measurement of T cell reactivity in spleen cells and peripheral blood mononuclear cells (PBMCs) in mice

T cell reactivity in mice was measured after injection of the spike antigen expression vectors (vectors 1 and 3) obtained in Example 3 as follows.

Specifically, mice administered the vaccine (vectors 1 and 3) of Example 5 were sacrificed 10 weeks after administration, blood was collected by orbital vein sampling, and the spleen was dissected. Spleen cells were crushed using a 70 μm cell sieve (BD Bioscience, part number: 352350) to obtain single cells, and then red blood cells were removed using ACK lysis buffers (Gibco, part number: A1049201). Peripheral blood mononuclear cells (PBMCs) were isolated from blood samples by density gradient centrifugation using Histopaque®-1077 (Sigma-Aldrich, catalog number: 10771). Isolated spleen cells and PBMCs were counted and suspended in RF10 culture medium (RPMI1640+10% FBS+1% penicillin/streptomycin) at a concentration of 2×10 ⁶ cells/ml.

SARS-CoV-2 peptivator Prot_S (Miltenyi Biotec, catalog number: 130-126-701) was added to pre-warmed RF10 culture medium at a concentration of 50 μg/ml, and to each well of the plate coated with murine IFN-γ from the ELISPOT kit ( CTL, catalog number: MIFNgp-2M/10), 100 μl of the mixture was added and kept in a CO ₂ incubator at 37°C for 20 minutes (wells for each group were prepared in duplicate). After this, 100 μl of culture medium containing resuspended mouse spleen cells and PBMCs was added to each well and cultured in a CO ₂ incubator at 37°C. Anti-CD3 mAb (1 μg/ml, Biolegend, catalog number: 100331) was added to the positive control well, and only RF10 was added to the negative control well without adding cells. After culture for 24 hours, ELISPOT staining was performed according to the manufacturer's protocol included in the mouse IFN-γ ELISPOT kit. After color development, the plate was dried at room temperature for 24 hours without access to light and then analyzed using an Immunospot S6 microanalyzer (CTL). The results were converted to 1×10 ⁶ PBMC units.

As a result, as shown in FIG. 13, it was confirmed that in mice injected with vector 3, T cell reactivity was significantly increased in spleen cells and peripheral blood mononuclear cells (PBMCs) compared with the no-vector group and the vector 1-injected group. The above results suggest that the vaccine composition of the present invention is capable of actively inducing memory T cell immune responses as well as antibody production upon reinfection with SARS-CoV-2.

<7-2> Measurement of T cell reactivity in peripheral blood mononuclear cells (PBMCs) in monkeys

The reactivity of T cells in monkeys was measured after injection of adenoviral vectors (vectors 1 and 3) obtained in example 3, as follows.

The monkey administered the vaccine of Example 6 (vector 3) was bled (5 ml) by intravenous blood draw 4 weeks after administration. Peripheral blood mononuclear cells (PBMCs) were isolated from blood samples by density gradient centrifugation using Histopaque®-1077 (Sigma-Aldrich, part number: 10771), and then using ACK lysis buffers (Gibco, part number: A1049201) , red blood cells were removed. The separated PBMCs were counted and suspended in RF10 culture medium (RPMI1640+10% FBS+1% penicillin/streptomycin) at a concentration of 2×10 ⁶ cells/ml.

SARS-CoV-2 peptivator Prot_S (Miltenyi Biotec, catalog number: 130-126-701) was added to pre-warmed RF10 culture medium at a concentration of 100 μg/ml, and to each well of the plate coated with human IFN-γ from the ELISPOT kit ( CTL, catalog number: HIFNgp-2M/10), 100 μl of the mixture was added and kept in a CO ₂ incubator at 37°C for 20 minutes (wells for each group were prepared in duplicate). After this, 100 μl of culture medium containing resuspended PBMCs was added to each well and cultured in a CO ₂ incubator at 37°C. PMA (10 ng/ml) and ionomycin (1 μg/ml) were added to the positive control well, and only RF10 was added to the negative control well without adding cells. After culture for 24 hours, ELISPOT staining was performed according to the manufacturer's protocol included in the human IFN-γ ELISPOT kit. After color development, the plate was dried at room temperature for 24 hours without access to light and then analyzed using an Immunospot S6 microanalyzer (CTL). The results were converted to 1×10 ⁶ PBMC units.

As a result, as shown in FIG. 14, it was confirmed that T cell reactivity was significantly increased in peripheral blood mononuclear cells (PBMCs) of monkeys injected with vector 3 compared with the group not injected with vector. The above results suggest that the vaccine composition of the present invention is capable of actively inducing memory T cell immune responses as well as antibody production upon reinfection with SARS-CoV-2.

<Example 8> Comparison of the equivalence of production of antigen-specific neutralizing antibodies in mice and monkeys depending on the injection of antigen expression vector 3 and heterogeneous antigen vector 3

<8-1> Comparison of the equivalence of antigen-specific neutralizing antibody production in mice depending on injection of antigen expression vector 3 and heterogeneous antigen expression vector 3

The level of antibody production was compared after injection of mice with vector 3 obtained in Example 3 and heterovector 3 (SEQ ID NO: 30) obtained as an equivalence comparison group. Heterovector 3 is a form in which the E4 gene among the adenoviral genes of vector 3 used in Example 3 is moved to the E1 region of the viral genome. Specifically, this vector is a form in which 711 bp have been removed. E4orf6 of an Ad5/35 vector in which the E3 knob gene is replaced by the Ad35 serotype in Ad5 with E1/E3 deleted, and a recombinant spike protein (a fusion protein in which the S1 domain and the S2 domain of SARS-CoV-2 are connected by a GGGGS linker) and the E4orf6 gene are inserted directly to the E1 deletion site. The vector was obtained in the same way as in example 3.

In particular, spike antigen expression vectors (vector 3 and heterovector 3) were injected intramuscularly into 6-7 week old BALB/c mice at a dose of 1×10 ⁹ HF/mouse, 5 mice per group. Approximately 300 μL of blood was collected from mice by orbital vein sampling 9 weeks after administration. Plasma was then separated by centrifugation (8000 rpm, 10 minutes, 20°C) and the amount of neutralizing antibodies present in the blood was measured using a pseudovirus neutralization assay.

For the pseudovirus neutralization assay, the HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was plated in a 96-well plate at a density of 1 x 10 ⁴ cells/well and cultured for 10 hours (37°C, 5% CO ₂ ). Plasma collected from mice by intravenous sampling 8 weeks after immunization was diluted 4-fold from 100 to 6400 times and reacted with 7×10 ⁵ units/ml pseudovirus (lentivirus expressing spike protein and luciferase) for 1 hour (37°C), followed by culture in a 96-well plate containing HEK293T-hACE2 cells cultured for 3 days. The presence of neutralizing antibodies binding to the spike protein in plasma was then confirmed by measuring the level of luciferase protein expression induced by infection of the HEK293T-hACE2 cell line with the pseudovirus. Cells cultured for 3 days were washed with DPBS and then lysed with 25 μg of cell lysis reagent (Promega, catalog number: E153A). After transferring the lysed sample to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, catalog number: E151A) was added to each well and the luminescence level was measured (detection indicator injection - stirring for 5 seconds - 2 second delay - measurement for 10 seconds) using a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, catalog number: LB960, software: Mikro 2000 program).

As a result, as shown in FIG. 15, antigenic vector 3 and antigenic heterovector 3 showed high levels of antibody production, and no difference was observed between the two groups. The above results suggest that antigen 3 has equivalent levels of neutralizing antibody activity even when vectors are loaded on different platforms.

<8-2> Comparison of the equivalence of antigen-specific neutralizing antibody production in monkeys depending on injection of antigen expression vector 3 and heterogeneous antigen expression vector 3

The level of production of antigen-specific neutralizing antibodies was compared after injection of vector 3 and heterovector 3, obtained as the comparison group for the equivalence of Example 8-1, into cynomolgus monkeys.

Specifically, spike antigen expression vectors (vector 3 and heterovector 3) were injected intramuscularly into 6-7 week old monkeys at a dose of 2×10 ¹⁰ HF/monkey, 2 monkeys per group. Blood was collected from monkeys by intravenous blood sampling 9 weeks after immunization. Plasma was then separated by centrifugation (8000 rpm, 10 minutes, 20°C) and the amount of neutralizing antibodies present in the blood was measured using a pseudovirus neutralization assay.

For the pseudovirus neutralization assay, the HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was plated in a 96-well plate at a density of 1 x 10 ⁴ cells/well and cultured for 10 hours (37°C, 5% CO ₂ ). Plasma collected from monkeys by intravenous blood sampling 9 weeks after immunization was diluted 4-fold from 100 to 6400 times and reacted with 7 × 10 ⁵ units/ml pseudovirus (lentivirus expressing spike protein and luciferase) for 1 hour (37°C), followed by culture in a 96-well plate containing HEK293T-hACE2 cells cultured for 3 days. The presence of neutralizing antibodies binding to the spike protein in plasma was then confirmed by measuring the extent of luciferase protein expression induced by infection of the HEK293T-hACE2 cell line with the pseudovirus. Cells cultured for 3 days were washed with DPBS and then lysed with 25 μg of cell lysis reagent (Promega, catalog number: E153A). After transferring the lysed sample to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, catalog number: E151A) was added to each well and the luminescence level was measured (detection indicator injection - stirring for 5 seconds - 2 second delay - measurement for 10 seconds) using a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, catalog number: LB960, software: Mikro 2000 program).

As a result, as shown in FIG. 16, vector 3 and heterovector 3 showed high levels of antibody production, with no difference in expression levels.

<Example 9> Comparison of antibody production in mice depending on injection of recombinant spike proteins

<9-1> Comparison of antibody production in mice by injection of recombinant spike protein

Levels of antibody production were compared after injection of mice with recombinant spike proteins (recombinant protein 2 and recombinant protein 3) derived from vectors 1-3 created in Example 3.

Specifically, recombinant spike proteins derived from vectors 1-3 were injected intramuscularly into 6-7 week old BALB/c mice, 6 mice per group. 10 μg of each recombinant spike protein (1-3) was diluted in 150 μl PBS (pH 7.4) and administered by intramuscular injection. Approximately 300 μl of blood sample was collected by drawing blood from the orbital vein 2-4 weeks after administration. Plasma was then separated by centrifugation (8000 rpm, 10 minutes, 20°C) and the amount of neutralizing antibodies present in the blood was measured using an enzyme-linked immunosorbent assay (ELISA) and a pseudovirus neutralization assay.

For enzyme-linked immunosorbent assay, a 96-well plate was coated with spike protein (Acro Biosystems, catalog number: SPN-C52H84) dissolved in PBSN (1 L PBS + 0.01 g sodium azide) at a concentration of 100 ng/well, followed by a cold reaction. at 4°C for 16 hours. After coating the 96-well plate for 16 hours, the coating protein was removed, washed three times with PBS, and then 150 μl of blocking buffer (PBSN+BSA 1%) was added to each well, followed by reaction (37°C, 90 minutes). During the reaction, the plasma was diluted 6400 times in dilution buffer (PBSN+0.1% BSA+0.05% Tween-20), and after the blocking reaction, the plate was washed three times with PBS, and then 50 μl of the diluted plasma sample was added to each well. followed by reaction (37°C, 3 hours). Upon completion of the reaction, the plate was washed three times with PBS and 50 μl of secondary antibodies, GAM-IgG-HRP (Southernbiotech, catalog number: 1030-05) and GAM-IgM-HRP (Southernbiotech, catalog number: 1020-05) were added to each well. , diluted 1000 times with dilution buffer, followed by reaction (37°C, 2 hours). Secondary antibodies were then removed, the plate was washed 5 times with PBS, and 50 μl of chromogenic reagent (TMB Peroxidase substrate buffer, ROCKLAND, catalog number: TMBE-1000) was added to each well, followed by color development for 15 minutes. Color development was stopped by adding 50 μl of 0.25 N to each well. HCl and the sample was analyzed at 450 nm using a microreader.

For the pseudovirus neutralization assay, the HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was plated in a 96-well plate at a density of 1 x 10 ⁴ cells/well and cultured for 10 hours (37°C, 5% CO ₂ ). Plasma collected from mice by intravenous sampling 2-4 weeks after immunization was diluted 4-fold from 100 to 6400 times and reacted with 7 × 10 ⁵ units/ml pseudovirus (lentivirus expressing spike protein and luciferase) for 1 hour (37°C), followed by culture in a 96-well plate containing HEK293T-hACE2 cells cultured for 3 days. The presence of neutralizing antibodies binding to the spike protein in plasma was then confirmed by measuring the extent of luciferase protein expression induced by infection of the HEK293T-hACE2 cell line with the pseudovirus. Cells cultured for 3 days were washed with DPBS and then lysed with 25 μg of cell lysis reagent (Promega, catalog number: E153A). After transferring the lysed sample to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, catalog number: E151A) was added to each well and the luminescence level was measured (detection indicator injection - stirring for 5 seconds - 2 second delay - measurement for 10 seconds) using a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, catalog number: LB960, software: Mikro 2000 program).

<Example 10> Comparison of antibody production levels in mice depending on injection of spike antigen plasmids

<10-1> Comparison of antibody production levels in mice as a function of injection of spike antigen plasmids

Levels of antibody production were compared after injection into mice of vectors 1-3 obtained in examples 1 and 2, in the form of plasmids (plasmid vector 1 and plasmid vector 3).

Specifically, plasmid vectors 2 and 3 obtained in Examples 1 and 2 were introduced into E. coli and cultured in 200 ml LB culture medium for one day. Cultured plasmids were collected using the QIAGEN Endofree Plasmid Maxi kit (cat. no. 12362) and then administered to 6-7 week old BALB/c mice, 6 mice per group. 100 μg of each vector (2 and 3) was diluted in 50 μl PBS (pH 7.4) and administered by intramuscular injection. Approximately 300 μl of blood sample was collected by drawing blood from the orbital vein 2-4 weeks after administration. Plasma was then separated by centrifugation (8000 rpm, 10 minutes, 20°C) and the amount of neutralizing antibodies present in the blood was measured using an enzyme-linked immunosorbent assay (ELISA) and a pseudovirus neutralization assay.

For enzyme-linked immunosorbent assay, a 96-well plate was coated with spike protein (Acro Biosystems, catalog number: SPN-C52H84) dissolved in PBSN (1 L PBS + 0.01 g sodium azide) at a concentration of 100 ng/well, followed by a cold reaction. at 4°C for 16 hours. After coating the 96-well plate for 16 hours, the coating protein was removed, washed three times with PBS, and then 150 μl of blocking buffer (PBSN+BSA 1%) was added to each well, followed by reaction (37°C, 90 minutes). During the reaction, the plasma was diluted 6400 times in dilution buffer (PBSN+0.1% BSA+0.05% Tween-20), and after the blocking reaction, the plate was washed three times with PBS, and then 50 μl of the diluted plasma sample was added to each well. followed by reaction (37°C, 3 hours). Upon completion of the reaction, the plate was washed three times with PBS and 50 μl of secondary antibodies, GAM-IgG-HRP (Southernbiotech, catalog number: 1030-05) and GAM-IgM-HRP (Southernbiotech, catalog number: 1020-05) were added to each well. , diluted 1000 times with dilution buffer, followed by reaction (37°C, 2 hours). Secondary antibodies were then removed, the plate was washed 5 times with PBS, and 50 μl of chromogenic reagent (TMB Peroxidase substrate buffer, ROCKLAND, catalog number: TMBE-1000) was added to each well, followed by color development for 15 minutes. Color development was stopped by adding 50 μl of 0.25 N to each well. HCl and the sample was analyzed at 450 nm using a microreader.

For the pseudovirus neutralization assay, the HEK293T-hACE2 (human angiotensin converting enzyme 2; hACE2) cell line was plated in a 96-well plate at a density of 1 x 10 ⁴ cells/well and cultured for 10 hours (37°C, 5% CO ₂ ). Plasma collected from mice by intravenous sampling 2-4 weeks after immunization was diluted 4-fold from 100 to 6400 times and reacted with 7 × 10 ⁵ units/ml pseudovirus (lentivirus expressing spike protein and luciferase) , for 1 hour (37°C) followed by culture in a 96-well plate containing HEK293T-hACE2 cells cultured for 3 days. The presence of neutralizing antibodies binding to the spike protein in plasma was then confirmed by measuring the extent of luciferase protein expression induced by infection of the HEK293T-hACE2 cell line with the pseudovirus. Cells cultured for 3 days were washed with DPBS and then lysed with 25 μg of cell lysis reagent (Promega, catalog number: E153A). After transferring the lysed sample to an opaque 96-well plate, 100 μg of luciferase detection indicator (Promega, catalog number: E151A) was added to each well and the luminescence level was measured (detection indicator injection - stirring for 5 seconds - 2 second delay - measurement for 10 seconds) using a luminometer (Luminometer Centro XS3 LB960, Berthold Technologies, catalog number: LB960, software: Mikro 2000 program).

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LIST OF SEQUENCES

<110> Cellid Co.,Ltd.

<120> New recombinant coronavirus spike protein encoding it

polynucleotide, a vector containing a polynucleotide, and a vaccine for the prevention or

treatment of coronavirus infection containing vector

<130> 2021P-08-021

<150> KR 10-2020-0108276

<151> 2020-08-27

<160> 30

<170> KoPatentIn 3.0

<210> 1

<211> 34030

<212> DNA

<213> Artificial sequence

<220>

<223> pAdk35F

<400> 1

ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag 180

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa 780

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt 1020

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc 1200

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320

ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tactgggcta 1440

tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500

ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560

cgccctctgg taaggttggg aagccctgca aagtaaactg gatggctttc ttgccgccaa 1620

ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860

aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc 2040

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg 2460

acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520

gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640

aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt 2880

aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940

atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000

tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060

atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120

tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180

aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240

gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 3300

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta 3600

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccatg 3720

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780

actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca 3840

gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt cgacgagctc 3900

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa 3960

gacaccggga ccgatccagc ctccgattta aattgatcat aatcagccat accacatttg 4020

tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa 4080

tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca 4140

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 4200

ccaaactcat caatgtatct taacgcggat ctgggcgtgg ttaagggtgg gaaagaatat 4260

ataaggtggg ggtcttatgt agttttgtat ctgttttgca gcagccgccg ccgccatgag 4320

caccaactcg tttgatggaa gcattgtgag ctcatatttg acaacgcgca tgcccccatg 4380

ggccggggtg cgtcagaatg tgatgggctc cagcattgat ggtcgccccg tcctgcccgc 4440

aaactctact accttgacct acgagaccgt gtctggaacg ccgttggaga ctgcagcctc 4500

cgccgccgct tcagccgctg cagccaccgc ccgcgggatt gtgactgact ttgctttcct 4560

gagcccgctt gcaagcagtg cagcttcccg ttcatccgcc cgcgatgaca agttgacggc 4620

tcttttggca caattggatt ctttgacccg ggaacttaat gtcgtttctc agcagctgtt 4680

ggatctgcgc cagcaggttt ctgccctgaa ggcttcctcc cctcccaatg cggtttaaaa 4740

cataaataaa aaaccagact ctgtttggat ttggatcaag caagtgtctt gctgtcttta 4800

tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgaggtcct 4860

gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4920

cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4980

gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 5040

gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 5100

gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 5160

agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 5220

cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 5280

gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 5340

ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 5400

gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 5460

atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 5520

tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg tagggggagat 5580

cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 5640

aatcacacct attaccggct gcaactggta gttaagagag ctgcagctgc cgtcatccct 5700

gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5760

cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5820

cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5880

gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5940

gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 6000

atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 6060

gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 6120

tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 6180

ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 6240

cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 6300

gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 6360

cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 6420

tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 6480

ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 6540

tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 6600

tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 6660

gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6720

gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6780

agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6840

ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6900

agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6960

aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 7020

tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 7080

cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 7140

ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 7200

cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 7260

tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 7320

atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 7380

tatgggttga gtggggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 7440

caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 7500

ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 7560

ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 7620

tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 7680

accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7740

acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7800

cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7860

tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7920

gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7980

agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 8040

aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 8100

cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 8160

aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 8220

gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 8280

cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 8340

gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 8400

gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 8460

cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 8520

cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 8580

ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 8640

taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 8700

aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8760

tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8820

cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8880

agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8940

tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 9000

gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 9060

tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 9120

tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 9180

ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 9240

gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 9300

gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 9360

gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 9420

cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 9480

tgagcttgaa cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 9540

ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 9600

gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 9660

cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9720

ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9780

gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgagg 9840

tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9900

tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9960

aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 10020

cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 10080

cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 10140

ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 10200

gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 10260

cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 10320

taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 10380

ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 10440

gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 10500

tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 10560

ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 10620

tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 10680

cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10740

gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10800

gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10860

tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10920

tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10980

acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 11040

actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 11100

ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 11160

acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 11220

agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 11280

cgcaatcgtt gacgctctag cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg 11340

tctggtggat aaattcgcaa gggtatcatg gcggacgacc ggggttcgag ccccgtatcc 11400

ggccgtccgc cgtgatccat gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc 11460

agacaacggg ggagtgctcc ttttggcttc cttccaggcg cggcggctgc tgcgctagct 11520

tttttggcca ctggccgcgc gcagcgtaag cggttaggct ggaaagcgaa agcattaagt 11580

ggctcgctcc ctgtagccgg agggttattt tccaagggtt gagtcgcggg acccccggtt 11640

cgagtctcgg accggccgga ctgcggcgaa cggggggtttg cctccccgtc atgcaagacc 11700

ccgcttgcaa attcctccgg aaacagggac gagccccttt tttgcttttc ccagatgcat 11760

ccggtgctgc ggcagatgcg cccccctcct cagcagcggc aagagcaaga gcagcggcag 11820

acatgcaggg caccctcccc tcctcctacc gcgtcaggag gggcgacatc cgcggttgac 11880

gcggcagcag atggtgatta cgaacccccg cggcgccggg cccggcacta cctggacttg 11940

gaggagggcg agggcctggc gcggctagga gcgccctctc ctgagcggca cccaagggtg 12000

cagctgaagc gtgatacgcg tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc 12060

gagggagagg agcccgagga gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg 12120

catggcctga atcgcgagcg gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc 12180

gggattagtc ccgcgcgcgc acacgtggcg gccgccgacc tggtaaccgc atacgagcag 12240

acggtgaacc aggagattaa ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg 12300

gcgcgcgagg aggtggctat aggactgatg catctgtggg actttgtaag cgcgctggag 12360

caaaacccaa atagcaagcc gctcatggcg cagctgttcc ttatagtgca gcacagcagg 12420

gacaacgagg cattcaggga tgcgctgcta aacatagtag agcccgaggg ccgctggctg 12480

ctcgatttga taaacatcct gcagagcata gtggtgcagg agcgcagctt gagcctggct 12540

gacaaggtgg ccgccatcaa ctattccatg cttagcctgg gcaagtttta cgcccgcaag 12600

atataccata ccccttacgt tcccatagac aaggaggtaa agatcgaggg gttctacatg 12660

cgcatggcgc tgaaggtgct taccttgagc gacgacctgg gcgtttatcg caacgagcgc 12720

atccacaagg ccgtgagcgt gagccggcgg cgcgagctca gcgaccgcga gctgatgcac 12780

agcctgcaaa gggccctggc tggcacgggc agcggcgata gagaggccga gtcctacttt 12840

gacgcgggcg ctgacctgcg ctgggcccca agccgacgcg ccctggaggc agctggggcc 12900

ggacctgggc tggcggtggc acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat 12960

gacgaggacg atgagtacga gccagaggac ggcgagtact aagcggtgat gtttctgatc 13020

agatgatgca agacgcaacg gacccggcgg tgcgggcggc gctgcagagc cagccgtccg 13080

gccttaactc cacggacgac tggcgccagg tcatggaccg catcatgtcg ctgactgcgc 13140

gcaatcctga cgcgttccgg cagcagccgc aggccaaccg gctctccgca attctggaag 13200

cggtggtccc ggcgcgcgca aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc 13260

tggccgaaaa cagggccatc cggcccgacg aggccggcct ggtctacgac gcgctgcttc 13320

agcgcgtggc tcgttacaac agcggcaacg tgcagaccaa cctggaccgg ctggtggggg 13380

atgtgcgcga ggccgtggcg cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca 13440

tggttgcact aaacgccttc ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg 13500

actacaccaa ctttgtgagc gcactgcggc taatggtgac tgagacaccg caaagtgagg 13560

tgtaccagtc tgggccagac tattttttcc agaccagtag acaaggcctg cagaccgtaa 13620

acctgagcca ggctttcaaa aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg 13680

accgcgcgac cgtgtctagc ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag 13740

cgcccttcac ggacagtggc agcgtgtccc gggacacata cctaggtcac ttgctgacac 13800

tgtaccgcga ggccataggt caggcgcatg tggacgagca tactttccag gagattacaa 13860

gtgtcagccg cgcgctgggg caggaggaca cgggcagcct ggaggcaacc ctaaactacc 13920

tgctgaccaa ccggcggcag aagatcccct cgttgcacag tttaaacagc gaggaggagc 13980

gcattttgcg ctacgtgcag cagagcgtga gccttaacct gatgcgcgac ggggtaacgc 14040

ccagcgtggc gctggacatg accgcgcgca acatggaacc gggcatgtat gcctcaaacc 14100

ggccgtttat caaccgccta atggactact tgcatcgcgc ggccgccgtg aaccccgagt 14160

atttcaccaa tgccatcttg aacccgcact ggctaccgcc ccctggtttc tacaccgggg 14220

gattcgaggt gcccgagggt aacgatggat tcctctggga cgacatagac gacagcgtgt 14280

tttccccgca accgcagacc ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc 14340

tgcgaaagga aagcttccgc aggccaagca gcttgtccga tctaggcgct gcggccccgc 14400

ggtcagatgc tagtagccca tttccaagct tgatagggtc tcttaccagc actcgcacca 14460

cccgcccgcg cctgctgggc gaggaggagt acctaaacaa ctcgctgctg cagccgcagc 14520

gcgaaaaaaa cctgcctccg gcatttccca acaacgggat agagagccta gtggacaaga 14580

tgagtagatg gaagacgtac gcgcaggagc acagggacgt gccaggcccg cgcccgccca 14640

cccgtcgtca aaggcacgac cgtcagcggg gtctggtgtg ggagaggacgat gactcggcag 14700

acgacagcag cgtcctggat ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca 14760

ggctggggag aatgttttaa aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg 14820

ccatggcacc gagcgttggt tttcttgtat tccccttagt atgcggcgcg cggcgatgta 14880

tgaggaaggt cctcctccct cctacgagag tgtggtgagc gcggcgccag tggcggcggc 14940

gctgggttct cccttcgatg ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg 15000

gcctaccggg gggagaaaca gcatccgtta ctctgagttg gcacccctat tcgacaccac 15060

ccgtgtgtac ctggtggaca acaagtcaac ggatgtggca tccctgaact accagaacga 15120

ccacagcaac tttctgacca cggtcattca aaacaatgac tacagcccgg gggaggcaag 15180

cacacagacc atcaatcttg acgaccggtc gcactggggc ggcgacctga aaaccatcct 15240

gcataccaac atgccaaatg tgaacgagtt catgtttacc aataagttta aggcgcgggt 15300

gatggtgtcg cgcttgccta ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga 15360

gttcacgctg cccgagggca actactccga gaccatgacc atagacctta tgaacaacgc 15420

gatcgtggag cactacttga aagtgggcag acagaacggg gttctggaaa gcgacatcgg 15480

ggtaaagttt gacacccgca acttcagact ggggtttgac cccgtcactg gtcttgtcat 15540

gcctggggta tatacaaacg aagccttcca tccagacatc attttgctgc caggatgcgg 15600

ggtggacttc acccacagcc gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt 15660

ccaggagggc tttaggatca cctacgatga tctggagggt ggtaacattc ccgcactgtt 15720

ggatgtggac gcctaccagg cgagcttgaa agatgacacc gaacagggcg ggggtggcgc 15780

aggcggcagc aacagcagtg gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc 15840

aatgcagccg gtggaggaca tgaacgatca tgccattcgc ggcgacacct ttgccacacg 15900

ggctgaggag aagcgcgctg aggccgaagc agcggccgaa gctgccgccc ccgctgcgca 15960

acccgaggtc gagaagcctc agaagaaacc ggtgatcaaa cccctgacag aggacagcaa 16020

gaaacgcagt tacaacctaa taagcaatga cagcaccttc acccagtacc gcagctggta 16080

ccttgcatac aactacggcg accctcagac cggaatccgc tcatggaccc tgctttgcac 16140

tcctgacgta acctgcggct cggagcaggt ctactggtcg ttgccagaca tgatgcaaga 16200

ccccgtgacc ttccgctcca cgcgccagat cagcaacttt ccggtggtgg gcgccgagct 16260

gttgcccgtg cactccaaga gcttctacaa cgaccaggcc gtctactccc aactcatccg 16320

ccagtttacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 16380

cccgccagcc cccaccatca ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg 16440

gacgctaccg ctgcgcaaca gcatcggagg agtccagcga gtgaccatta ctgacgccag 16500

acgccgcacc tgcccctacg tttacaaggc cctgggcata gtctcgccgc gcgtcctatc 16560

gagccgcact ttttgagcaa gcatgtccat ccttatatcg cccagcaata acacaggctg 16620

gggcctgcgc ttcccaagca agatgtttgg cggggccaag aagcgctccg accaacaccc 16680

agtgcgcgtg cgcgggcact accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg 16740

gcgcaccacc gtcgatgacg ccatcgacgc ggtggtggag gaggcgcgca actacacgcc 16800

cacgccgcca ccagtgtcca cagtggacgc ggccattcag accgtggtgc gcggagcccg 16860

gcgctatgct aaaatgaaga gacggcggag gcgcgtagca cgtcgccacc gccgccgacc 16920

cggcactgcc gcccaacgcg cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg 16980

acgggcggcc atgcgggccg ctcgaaggct ggccgcgggt attgtcactg tgccccccag 17040

gtccaggcga cgagcggccg ccgcagcagc cgcggccatt agtgctatga ctcagggtcg 17100

caggggcaac gtgtattggg tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac 17160

ccgccccccg cgcaactaga ttgcaagaaa aaactactta gactcgtact gttgtatgta 17220

tccagcggcg gcggcgcgca acgaagctat gtccaagcgc aaaatcaaag aagagatgct 17280

ccaggtcatc gcgccggaga tctatggccc cccgaagaag gaagagcagg attacaagcc 17340

ccgaaagcta aagcgggtca aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga 17400

ggtggaactg ctgcacgcta ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt 17460

aaaacgtgtt ttgcgacccg gcaccaccgt agtctttacg cccggtgagc gctccacccg 17520

cacctacaag cgcgtgtatg atgaggtgta cggcgacgag gacctgcttg agcaggccaa 17580

cgagcgcctc ggggagtttg cctacggaaa gcggcataag gacatgctgg cgttgccgct 17640

ggacgagggc aacccaacac ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc 17700

gcttgcaccg tccgaagaaa agcgcggcct aaagcgcgag tctggtgact tggcaccac 17760

cgtgcagctg atggtaccca agcgccagcg actggaagat gtcttggaaa aaatgaccgt 17820

ggaacctggg ctggagcccg aggtccgcgt gcggccaatc aagcaggtgg cgccgggact 17880

gggcgtgcag accgtggacg ttcagatacc cactaccagt agcaccagta ttgccaccgc 17940

cacagagggc atggagacac aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt 18000

gcaggcggtc gctgcggccg cgtccaagac ctctacggag gtgcaaacgg acccgtggat 18060

gtttcgcgtt tcagcccccc ggcgcccgcg ccgttcgagg aagtacggcg ccgccagcgc 18120

gctactgccc gaatatgccc tacatccttc cattgcgcct acccccggct atcgtggcta 18180

cacctaccgc cccagaagac gagcaactac ccgacgccga accaccactg gaacccgccg 18240

ccgccgtcgc cgtcgccagc ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga 18300

aggaggcagg accctggtgc tgccaacagc gcgctaccac cccagcatcg tttaaaagcc 18360

ggtctttgtg gttcttgcag atatggccct cacctgccgc ctccgtttcc cggtgccggg 18420

attccgagga agaatgcacc gtaggagggg catggccggc cacggcctga cgggcggcat 18480

gcgtcgtgcg caccaccggc ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct 18540

gcccctcctt attccactga tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt 18600

ggccttgcag gcgcagagac actgattaaa aacaagttgc atgtggaaaa atcaaaataa 18660

aaagtctgga ctctcacgct cgcttggtcc tgtaactatt ttgtagaatg gaagacatca 18720

actttgcgtc tctggccccg cgacacggct cgcgcccgtt catgggaaac tggcaagata 18780

tcggcaccag caatatgagc ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta 18840

aaaatttcgg ttccaccgtt aagaactatg gcagcaaggc ctggaacagc agcacaggcc 18900

agatgctgag ggataagttg aaagagcaaa atttccaaca aaaggtggta gatggcctgg 18960

cctctggcat tagcggggtg gtggacctgg ccaaccaggc agtgcaaaat aagattaaca 19020

gtaagcttga tccccgccct cccgtagagg agcctccacc ggccgtggag acagtgtctc 19080

cagaggggcg tggcgaaaag cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa 19140

tagacgagcc tccctcgtac gaggaggcac taaagcaagg cctgcccacc acccgtccca 19200

tcgcgcccat ggctaccgga gtgctgggcc agcacacacc cgtaacgctg gacctgcctc 19260

cccccgccga cacccagcag aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc 19320

gtcctagccg cgcgtccctg cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag 19380

ccagtggcaa ctggcaaagc acactgaaca gcatcgtggg tctgggggtg caatccctga 19440

agcgccgacg atgcttctga tagctaacgt gtcgtatgtg tgtcatgtat gcgtccatgt 19500

cgccgccaga ggagctgctg agccgccgcg cgcccgcttt ccaagatggc taccccttcg 19560

atgatgccgc agtggtctta catgcacatc tcgggccagg acgcctcgga gtacctgagc 19620

cccggggctgg tgcagtttgc ccgcgccacc gagacgtact tcagcctgaa taacaagttt 19680

agaaacccca cggtggcgcc tacgcacgac gtgaccacag accggtccca gcgtttgacg 19740

ctgcggttca tccctgtgga ccgtgaggat actgcgtact cgtacaaggc gcggttcacc 19800

ctagctgtgg gtgataaccg tgtgctggac atggcttcca cgtactttga catccgcggc 19860

gtgctggaca ggggccctac ttttaagccc tactctggca ctgcctacaa cgccctggct 19920

cccaagggtg ccccaaatcc ttgcgaatgg gatgaagctg ctactgctct tgaaataaac 19980

ctagaagaag aggacgatga caacgaagac gaagtagacg agcaagctga gcagcaaaaa 20040

actcacgtat ttgggcaggc gccttattct ggtataaata ttacaaagga gggtattcaa 20100

ataggtgtcg aaggtcaaac acctaaatat gccgataaaa catttcaacc tgaacctcaa 20160

ataggagaat ctcagtggta cgaaacagaa attaatcatg cagctgggag agtcctaaaa 20220

aagactaccc caatgaaacc atgttacggt tcatatgcaa aacccacaaa tgaaaatgga 20280

gggcaaggca ttcttgtaaa gcaacaaaat ggaaagctag aaagtcaagt ggaaatgcaa 20340

tttttctcaa ctactgaggc agccgcaggc aatggtgata acttgactcc taaagtggta 20400

ttgtacagtg aagatgtaga tatagaaacc cgacactc atatttctta catgcccact 20460

attaaggaag gtaactcacg agaactaatg ggccaacaat ctatgcccaa caggcctaat 20520

tacattgctt ttagggacaa ttttattggt ctaatgtatt acaacagcac gggtaatatg 20580

ggtgttctgg cgggccaagc atcgcagttg aatgctgttg tagatttgca agacagaaac 20640

acagagcttt cataccagct tttgcttgat tccattggtg atagaaccag gtacttttct 20700

atgtggaatc aggctgttga cagctatgat ccagatgtta gaattattga aaatcatgga 20760

actgaagatg aacttccaaa ttactgcttt ccactgggag gtgtgattaa tacagagact 20820

cttaccaagg taaaacctaa aacaggtcag gaaaatggat gggaaaaaga tgctacagaa 20880

ttttcagata aaaatgaaat aagagttgga aataattttg ccatggaaat caatctaaat 20940

gccaacctgt ggagaaattt cctgtactcc aacatagcgc tgtatttgcc cgacaagcta 21000

aagtacagtc cttccaacgt aaaaatttct gataacccaa acacctacga ctacatgaac 21060

aagcgagtgg tggctcccgg gctagtggac tgctacatta accttggagc acgctggtcc 21120

cttgactata tggacaacgt caacccattt aaccaccacc gcaatgctgg cctgcgctac 21180

cgctcaatgt tgctgggcaa tggtcgctat gtgcccttcc acatccaggt gcctcagaag 21240

ttctttgcca ttaaaaacct ccttctcctg ccgggctcat acacctacga gtggaacttc 21300

aggaaggatg ttaacatggt tctgcagagc tccctaggaa atgacctaag ggttgacgga 21360

gccagcatta agtttgatag catttgcctt tacgccacct tcttccccat ggcccacaac 21420

accgcctcca cgcttgaggc catgcttaga aacgacacca acgaccagtc ctttaacgac 21480

tatctctccg ccgccaacat gctctaccct atacccgcca acgctaccaa cgtgcccata 21540

tccatcccct cccgcaactg ggcggctttc cgcggctggg ccttcacgcg ccttaagact 21600

aaggaaaccc catcactggg ctcggggctac gacccttatt acacctactc tggctctata 21660

ccctacctag atggaacctt ttacctcaac cacaccttta agaaggtggc cattaccttt 21720

gactcttctg tcagctggcc tggcaatgac cgcctgctta cccccaacga gtttgaaatt 21780

aagcgctcag ttgacgggga gggttacaac gttgcccagt gtaacatgac caaagactgg 21840

ttcctggtac aaatgctagc taactataac attggctacc agggcttcta tatcccagag 21900

agctacaagg accgcatgta ctccttcttt agaaacttcc agcccatgag ccgtcaggtg 21960

gtggatgata ctaaatacaa ggactaccaa caggtgggca tcctacacca acacaacaac 22020

tctggatttg ttggctacct tgcccccacc atgcgcgaag gacaggccta ccctgctaac 22080

ttcccctatc cgcttatagg caagaccgca gttgacagca ttacccagaa aaagtttctt 22140

tgcgatcgca ccctttggcg catcccattc tccagtaact ttatgtccat gggcgcactc 22200

acagacctgg gccaaaacct tctctacgcc aactccgccc acgcgctaga catgactttt 22260

gaggtggatc ccatggacga gcccaccctt ctttatgttt tgtttgaagt ctttgacgtg 22320

gtccgtgtgc accagccgca ccgcggcgtc atcgaaaccg tgtacctgcg cacgcccttc 22380

tcggccggca acgccacaac ataaagaagc aagcaacatc aacaacagct gccgccatgg 22440

gctccagtga gcaggaactg aaagccattg tcaaagatct tggttgtggg ccatattttt 22500

tgggcaccta tgacaagcgc tttccaggct ttgtttctcc acacaagctc gcctgcgcca 22560

tagtcaatac ggccggtcgc gagactgggg gcgtacactg gatggccttt gcctggaacc 22620

cgcactcaaa aacatgctac ctctttgagc cctttggctt ttctgaccag cgactcaagc 22680

aggtttacca gtttgagtac gagtcactcc tgcgccgtag cgccattgct tcttcccccg 22740

accgctgtat aacgctggaa aagtccaccc aaagcgtaca ggggcccaac tcggccgcct 22800

gtggactatt ctgctgcatg tttctccacg cctttgccaa ctggccccaa actcccatgg 22860

atcacaaccc caccatgaac cttattaccg gggtacccaa ctccatgctc aacagtcccc 22920

aggtacagcc caccctgcgt cgcaaccagg aacagctcta cagcttcctg gagcgccact 22980

cgccctactt ccgcagccac agtgcgcaga ttaggagcgc cacttctttt tgtcacttga 23040

aaaacatgta aaaataatgt actagagaca ctttcaataa aggcaaatgc ttttatttgt 23100

acactctcgg gtgattattt acccccaccc ttgccgtctg cgccgtttaa aaatcaaagg 23160

ggttctgccg cgcatcgcta tgcgccactg gcagggacac gttgcgatac tggtgtttag 23220

tgctccactt aaactcaggc acaaccatcc gcggcagctc ggtgaagttt tcactccaca 23280

ggctgcgcac catcaccaac gcgtttagca ggtcgggcgc cgatatcttg aagtcgcagt 23340

tggggcctcc gccctgcgcg cgcgagttgc gatacacagg gttgcagcac tggaacacta 23400

tcagcgccgg gtggtgcacg ctggccagca cgctcttgtc ggagatcaga tccgcgtcca 23460

ggtcctccgc gttgctcagg gcgaacggag tcaactttgg tagctgcctt cccaaaaagg 23520

gcgcgtgccc aggctttgag ttgcactcgc accgtagtgg catcaaaagg tgaccgtgcc 23580

cggtctgggc gttaggatac agcgcctgca taaaagcctt gatctgctta aaagccacct 23640

gagcctttgc gccttcagag aagaacatgc cgcaagactt gccggaaaac tgattggccg 23700

gacaggccgc gtcgtgcacg cagcaccttg cgtcggtgtt ggagatctgc accacatttc 23760

ggccccaccg gttcttcacg atcttggcct tgctagactg ctccttcagc gcgcgctgcc 23820

cgttttcgct cgtcacatcc atttcaatca cgtgctcctt atttatcata atgcttccgt 23880

gtagacactt aagctcgcct tcgatctcag cgcagcggtg cagccacaac gcgcagcccg 23940

tgggctcgtg atgcttgtag gtcacctctg caaacgactg caggtacgcc tgcaggaatc 24000

gccccatcat cgtcacaaag gtcttgttgc tggtgaaggt cagctgcaac ccgcggtgct 24060

cctcgttcag ccaggtcttg catacggccg ccagagcttc cacttggtca ggcagtagtt 24120

tgaagttcgc ctttagatcg ttatccacgt ggtacttgtc catcagcgcg cgcgcagcct 24180

ccatgccctt ctcccacgca gacacgatcg gcacactcag cgggttcatc accgtaattt 24240

cactttccgc ttcgctgggc tcttcctctt cctcttgcgt ccgcatacca cgcgccactg 24300

ggtcgtcttc attcagccgc cgcactgtgc gcttacctcc tttgccatgc ttgattagca 24360

ccggtgggtt gctgaaaccc accatttgta gcgccacatc ttctctttct tcctcgctgt 24420

ccacgattac ctctggtgat ggcgggcgct cgggcttggg agaagggcgc ttctttttct 24480

tcttgggcgc aatggccaaa tccgccgccg aggtcgatgg ccgcgggctg ggtgtgcgcg 24540

gcaccagcgc gtcttgtgat gagtcttcct cgtcctcgga ctcgatacgc cgcctcatcc 24600

gcttttttgg gggcgcccgg ggaggcggcg gcgacgggga cggggacgac acgtcctcca 24660

tggttggggg acgtcgcgcc gcaccgcgtc cgcgctcggg ggtggtttcg cgctgctcct 24720

cttcccgact ggccatttcc ttctcctata ggcagaaaaa gatcatggag tcagtcgaga 24780

agaaggacag cctaaccgcc ccctctgagt tcgccaccac cgcctccacc gatgccgcca 24840

acgcgcctac caccttcccc gtcgaggcac ccccgcttga ggagggaggaa gtgattatcg 24900

agcaggaccc aggttttgta agcgaagacg acgaggaccg ctcagtacca acagaggata 24960

aaaagcaaga cccaggacaac gcagaggcaa acgaggaaca agtcgggcgg ggggacgaaa 25020

ggcatggcga ctacctagat gtgggagacg acgtgctgtt gaagcatctg cagcgccagt 25080

gcgccattat ctgcgacgcg ttgcaagagc gcagcgatgt gcccctcgcc atagcggatg 25140

tcagccttgc ctacgaacgc cacctattct caccgcgcgt accccccaaa cgccaagaaa 25200

acggcacatg cgagcccaac ccgcgcctca acttctaccc cgtatttgcc gtgccagagg 25260

tgcttgccac ctatcacatc tttttccaaa actgcaagat acccctatcc tgccgtgcca 25320

accgcagccg agcggacaag cagctggcct tgcggcaggg cgctgtcata cctgatatcg 25380

cctcgctcaa cgaagtgcca aaaatctttg agggtcttgg acgcgacgag aagcgcgcgg 25440

caaacgctct gcaacaggaa aacagcgaaa atgaaagtca ctctggagtg ttggtggaac 25500

tcgaggtga caacgcgcgc ctagccgtac taaaacgcag catcgaggtc acccactttg 25560

cctacccggc acttaaccta ccccccaagg tcatgagcac agtcatgagt gagctgatcg 25620

tgcgccgtgc gcagcccctg gagagggatg caaatttgca agaacaaaca gaggagggcc 25680

tacccgcagt tggcgacgag cagctagcgc gctggcttca aacgcgcgag cctgccgact 25740

tggagggagcg acgcaaacta atgatggccg cagtgctcgt taccgtggag cttgagtgca 25800

tgcagcggtt ctttgctgac ccggagatgc agcgcaagct agaggaaaca ttgcactaca 25860

cctttcgaca gggctacgta cgccaggcct gcaagatctc caacgtggag ctctgcaacc 25920

tggtctccta ccttggaatt ttgcacgaaa accgccttgg gcaaaacgtg cttcattcca 25980

cgctcaaggg cgaggcgcgc cgcgactacg tccgcgactg cgtttactta tttctatgct 26040

acacctggca gacggccatg ggcgtttggc agcagtgctt ggaggagtgc aacctcaagg 26100

agctgcagaa actgctaaag caaaacttga aggacctatg gacggccttc aacgagcgct 26160

ccgtggccgc gcacctggcg gacatcattt tccccgaacg cctgcttaaa accctgcaac 26220

agggtctgcc agacttcacc agtcaaagca tgttgcagaa ctttaggaac tttatcctag 26280

agcgctcagg aatcttgccc gccacctgct gtgcacttcc tagcgacttt gtgcccatta 26340

agtaccgcga atgccctccg ccgctttggg gccactgcta ccttctgcag ctagccaact 26400

accttgccta ccactctgac ataatggaag acgtgagcgg tgacggtcta ctggagtgtc 26460

actgtcgctg caacctatgc accccgcacc gctccctggt ttgcaattcg cagctgctta 26520

acgaaagtca aattatcggt acctttgagc tgcagggtcc ctcgcctgac gaaaagtccg 26580

cggctccggg gttgaaactc actccggggc tgtggacgtc ggcttacctt cgcaaatttg 26640

tacctgagga ctaccacgcc cacgagatta ggttctacga agaccaatcc cgcccgccta 26700

atgcggagct taccgcctgc gtcattaccc agggccacat tcttggccaa ttgcaagcca 26760

tcaacaaagc ccgccaagag tttctgctac gaaagggacg gggggtttac ttggaccccc 26820

agtccggcga ggagctcaac ccaatccccc cgccgccgca gccctatcag cagcagccgc 26880

gggcccttgc ttcccaggat ggcacccaaa aagaagctgc agctgccgcc gccacccacg 26940

gacgaggagg aatactggga cagtcaggca gaggaggttt tggacgagga ggaggaggac 27000

atgatggaag actgggagag cctagacgag gaagcttccg aggtcgaaga ggtgtcagac 27060

gaaacaccgt caccctcggt cgcattcccc tcgccggcgc cccagaaatc ggcaaccggt 27120

tccagcatgg ctacaacctc cgctcctcag gcgccgccgg cactgcccgt tcgccgaccc 27180

aaccgtagat gggacaccac tggaaccagg gccggtaagt ccaagcagcc gccgccgtta 27240

gcccaagagc aacaacagcg ccaaggctac cgctcatggc gcgggcacaa gaacgccata 27300

gttgcttgct tgcaagactg tggggggcaac atctccttcg cccgccgctt tcttctctac 27360

catcacggcg tggccttccc ccgtaacatc ctgcattact accgtcatct ctacagccca 27420

tactgcaccg gcggcagcgg cagcaacagc agcggccaca cagaagcaaa ggcgaccgga 27480

tagcaagact ctgacaaagc ccaagaaatc cacagcggcg gcagcagcag gaggaggagc 27540

gctgcgtctg gcgcccaacg aacccgtatc gacccgcgag cttagaaaca ggatttttcc 27600

cactctgtat gctatatttc aacagagcag gggccaagaa caagagctga aaataaaaaa 27660

caggtctctg cgatccctca cccgcagctg cctgtatcac aaaagcgaag atcagcttcg 27720

gcgcacgctg gaagacgcgg aggctctctt cagtaaatac tgcgcgctga ctcttaagga 27780

ctagtttcgc gccctttctc aaatttaagc gcgaaaacta cgtcatctcc agcggccaca 27840

cccggcgcca gcacctgttg tcagcgccat tatgagcaag gaaattccca cgccctacat 27900

gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact actcaacccg 27960

aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa tacgcgccca 28020

ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta ataaccttaa 28080

tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca ccactgtggt 28140

acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc agcttgcggg 28200

cggctttcgt cacaggtgc ggtcgcccgg gcagggtata actcacctga caatcagagg 28260

gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc gtccggacgg 28320

gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg caatcctaac 28380

tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc aatttattga 28440

ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc actatccgga 28500

tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg actgaatgtt 28560

aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc gccacaagtg 28620

ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc atatcgaggg 28680

cccggcgcac ggcgtccggc ttaccgccca ggggagagctt gcccgtagcc tgattcggga 28740

gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc tcactgtgat 28800

ttgcaactgt cctaaccctg gattacatca agatcctcta gttaatgtca ggtcgcctaa 28860

gtcgattaac tagagtaccc ggggatctta ttccctttaa ctaataaaaa aaaataataa 28920

agcatcactt acttaaaatc agttagcaaa tttctgtcca gtttattcag cagcacctcc 28980

ttgccctcct cccagctctg gtattgcagc ttcctcctgg ctgcaaactt tctccacaat 29040

ctaaatggaa tgtcagtttc ctcctgttcc tgtccatccg cacccactat cttcatgttg 29100

ttgcagatga agcgcgcaag accgtctgaa gataccttca accccgtgta tccatatgac 29160

acggaaaccg gtcctccaac tgtgcctttt cttactcctc cctttgtatc ccccaatggg 29220

tttcaagaga gtccccctgg ggtactctct ttgcgcctat ccgaacctct agttacctcc 29280

aatggcatgc ttgcgctcaa aatgggcaac ggcctctctc tggacgaggc cggcaacctt 29340

acctcccaaa atgtaaccac tgtgagccca cctctcaaaa aaaccaagtc aaacataaac 29400

ctggaaatat ctgcacccct cacagttacc tcagaagccc taactgtggc tgccgccgca 29460

cctctaatgg tcgcgggcaa cacactcacc atgcaatcac aggccccgct aaccgtgcac 29520

gactccaaac ttagcattgc cacccaagga cccctcacag tgtcagaagg aaagctagcc 29580

ctgcaaacat caggccccct caccaccacc gatagcagta cccttactat cactgcctca 29640

ccccctctaa ctactgccac tggtagcttg ggcattgact tgaaagagcc catttataca 29700

caaaatggaa aactaggact aaagtacggg gctcctttgc atgtaacaga cgacctaaac 29760

actttgaccg tagcaactgg tccaggtgtg actattaata atacttcctt gcaaactaaa 29820

gttactggag ccttgggttt tgattcacaa ggcaatatgc aacttaatgt agcaggagga 29880

ctaaggattg attctcaaaa cagacgcctt atacttgatg ttagttatcc gtttgatgct 29940

caaaaccaac taaatctaag actaggacag ggccctcttt ttataaactc agcccacaac 30000

ttggatatta actacaacaa aggcctttac ttgtttacag cttcaaacaa ttccaaaaag 30060

cttgaggtta acctaagcac tgccaagggg ttgatgtttg acgctacagc catagccatt 30120

aatgcaggag atgggcttga atttggttca cctaatgcac caaacacaaa tcccctcaaa 30180

acaaaaattg gccatggcct agaatttgat tcaaacaagg ctatggttcc taaactagga 30240

actggcctta gttttgacag cacaggtgcc attacagtag gaaacaaaaa taatgataag 30300

ctaactttgt ggaccggaat aaaccctcca cctaactgtc aaattgtgga aaacactaat 30360

acaaatgatg gcaaacttac tttagtatta gtaaaaaatg gagggcttgt taatggctac 30420

gtgtctctag ttggtgtatc agacactgtg aaccaaatgt tcacacaaaa gacagcaaac 30480

atccaattaa gattatattt tgactcttct ggaaatctat taactgagga atcagactta 30540

aaaattccac ttaaaaataa atcttctaca gcgaccagtg aaactgtagc cagcagcaaa 30600

gcctttatgc caagtactac agcttatccc ttcaacacca ctactaggga tagtgaaaac 30660

tacattcatg gaatatgtta ctacatgact agttatgata gaagtctatt tcccttgaac 30720

atttctataa tgctaaacag ccgtatgatt tcttccaatg ttgcctatgc catacaattt 30780

gaatggaatc taaatgcaag tgaatctcca gaaagcaaca tagctacgct gaccacatcc 30840

ccctttttct tttcttacat tacagaagac gacaactaaa gaatcgtttg tgttatgttt 30900

caacgtgttt atttttcaat tgcagaaaat ttcaagtcat ttttcattca gtagtatagc 30960

cccaccacca catagcttat acagatcacc gtaccttaat caaactcaca gaaccctagt 31020

attcaacctg ccacctccct cccaacacac agagtacaca gtcctttctc cccggctggc 31080

cttaaaaagc atcatatcat gggtaacaga catattctta ggtgttatat tccacacggt 31140

ttcctgtcga gccaaacgct catcagtgat attaataaac tccccgggca gctcacttaa 31200

gttcatgtcg ctgtccagct gctgagccac aggctgctgt ccaacttgcg gttgcttaac 31260

gggcggcgaa ggagaagtcc acgcctacat gggggtagag tcataatcgt gcatcaggat 31320

agggcggtgg tgctgcagca gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca 31380

ggaatacaac atggcagtgg tctcctcagc gatgattcgc accgcccgca gcataaggcg 31440

ccttgtcctc cgggcacagc agcgcaccct gatctcactt aaatcagcac agtaactgca 31500

gcacagcacc acaatattgt tcaaaatccc acagtgcaag gcgctgtatc caaagctcat 31560

ggcggggacc acagaaccca cgtggccatc ataccacaag cgcaggtaga ttaagtggcg 31620

acccctcata aacacgctgg acataaacat tacctctttt ggcatgttgt aattcaccac 31680

ctcccggtac catataaacc tctgattaaa catggcgcca tccaccacca tcctaaacca 31740

gctggccaaa acctgcccgc cggctataca ctgcagggaa ccgggactgg aacaatgaca 31800

gtggagagcc caggactcgt aaccatggat catcatgctc gtcatgatat caatgttggc 31860

acaacacagg cacacgtgca tacacttcct caggattaca agctcctccc gcgttagaac 31920

catatcccag ggaacaaccc attcctgaat cagcgtaaat cccacactgc agggaagacc 31980

tcgcacgtaa ctcacgttgt gcattgtcaa agtgttacat tcgggcagca gcggatgatc 32040

ctccagtatg gtagcgcggg tttctgtctc aaaaggaggt agacgatccc tactgtacgg 32100

agtgcgccga gacaaccgag atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga 32160

cgtagtcata tttcctgaag caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc 32220

ggtctcgccg cttagatcgc tctgtgtagt agttgtagta tatccactct ctcaaagcat 32280

ccaggcgccc cctggcttcg ggttctatgt aaactccttc atgcgccgct gccctgataa 32340

catccaccac cgcagaataa gccacaccca gccaacctac acattcgttc tgcgagtcac 32400

acacgggagg agcgggaaga gctggaagaa ccatgttttt ttttttattc caaaagatta 32460

tccaaaacct caaaatgaag atctattaag tgaacgcgct cccctccggt ggcgtggtca 32520

aactctacag ccaaagaaca gataatggca tttgtaagat gttgcacaat ggcttccaaa 32580

aggcaaacgg ccctcacgtc caagtggacg taaaggctaa acccttcagg gtgaatctcc 32640

tctataaaca ttccagcacc ttcaaccatg cccaaataat tctcatctcg ccaccttctc 32700

aatatatctc taagcaaatc ccgaatatta agtccggcca ttgtaaaaat ctgctccaga 32760

gcgccctcca ccttcagcct caagcagcga atcatgattg caaaaattca ggttcctcac 32820

agacctgtat aagattcaaa agcggaacat taacaaaaat accgcgatcc cgtaggtccc 32880

ttcgcagggc cagctgaaca taatcgtgca ggtctgcacg gaccagcgcg gccacttccc 32940

cgccaggaac catgacaaaa gaacccacac tgattatgac acgcatactc ggagctatgc 33000

taaccagcgt agccccgatg taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc 33060

tgctcaaaaa atcaggcaaa gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat 33120

gcagataaag gcaggtaagc tccggaacca cccacagaaaa agacaccatt tttctctcaa 33180

acatgtctgc gggtttctgc ataaacacaa aataaaataa caaaaaaaca tttaaacatt 33240

agaagcctgt cttacaacag gaaaaacaac ccttataagc ataagacgga ctacggccat 33300

gccggcgtga ccgtaaaaaa actggtcacc gtgattaaaa agcaccaccg acagctcctc 33360

ggtcatgtcc ggagtcataa tgtaagactc ggtaaacaca tcaggttgat tcacatcggt 33420

cagtgctaaa aagcgaccga aatagcccgg gggaatacat acccgcaggc gtagagacaa 33480

cattacagcc cccataggag gtataacaaa attaatagga gagaaaaaca cataaacacc 33540

tgaaaaaccc tcctgcctag gcaaaatagc accctcccgc tccagaacaa catacagcgc 33600

ttccacagcg gcagccataa cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa 33660

acaccactcg acacggcacc agctcaatca gtcacagtgt aaaaaagggc caagtgcaga 33720

gcgagtatat ataggactaa aaaatgacgt aacggttaaa gtccacaaaa aacacccaga 33780

aaaccgcacg cgaacctacg cccagaaacg aaagccaaaa aacccacaac ttcctcaaat 33840

cgtcacttcc gttttcccac gttacgtcac ttcccatttt aagaaaacta caattcccaa 33900

cacatacaag ttactccgcc ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc 33960

cacgtcacaa actccacccc ctcattatca tattggcttc aatccaaaat aaggtatatt 34020

attgatgatg 34030

<210> 2

<211> 9858

<212> DNA

<213> Artificial sequence

<220>

<223> pCMV3-SARS-CoV2(Spike ORF)

<400> 2

gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg 60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg 120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc 180

ttagggttag gcgttttgcg ctgcttcgcg agtacattta tattggctca tgtccaatat 240

gaccgccatg ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat 300

tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg 360

gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa 420

cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact 480

tggcagtaca tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta 540

aatggcccgc ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt 600

acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg 660

ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg 720

ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaat aaccccgccc 780

cgttgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt 840

tagtgaaccg tcagatcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 900

gctcgcggtt gaggacaaac tcttcgcggt ctttccagta ctcttggatc ggaaacccgt 960

cggcctccga acggtactcc gccaccgagg gacctgagcg agtccgcatc gaccggatcg 1020

gaaaacctct cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct gagcaccgtg 1080

gcgggcggca gcgggtggcg gtcggggttg tttctggcgg aggtgctgct gatgatgtaa 1140

ttaaagtagg cggtcttgag acggcggatg gtcgaggtga ggtgtggcag gcttgagatc 1200

cagctgttgg ggtgagtact ccctctcaaa agcgggcatt acttctgcgc taagattgtc 1260

agtttccaaa aacgaggagg atttgatatt cacctggccc gatctggcca tacacttgag 1320

tgacaatgac atccactttg cctttctctc cacaggtgtc cactcccagg tccaagttta 1380

aactttaata cgactcacta taggggccgc caccaagctt ggtaccatgt ttgtgttcct 1440

ggtgctgctg ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc 1500

tcctgcctac accaactcct tcaccagggg agtctactac cctgacaagg tgttcaggtc 1560

ctctgtgctg cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt 1620

ccatgccatc catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc 1680

attcaatgat ggagtctact ttgccagcac agagaagagc aacatcatca ggggctggat 1740

ttttggcacc accctggaca gcaagacca gtccctgctg attgtgaaca atgccaccaa 1800

tgtggtgatt aaggtgtgtg agttccagtt ctgtaatgac ccattcctgg gagtctacta 1860

ccacaagaac aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa 1920

ctgtaccttt gaatatgtga gccaaccatt cctgatggac ttggagggca agcagggcaa 1980

cttcaagaac ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag 2040

caaacacaca ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc 2100

actggtggac ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca 2160

caggtcctac ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta 2220

ctatgtgggc tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat 2280

cacagatgct gtggactgtg ccctggaccc actngtctgag accaagtgta ccctgaaatc 2340

cttcacagtg gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag 2400

cattgtgagg tttccaaaca tcaccaacct gtgtccatt ggagaggtgt tcaatgccac 2460

caggtttgcc tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta 2520

ctctgtgctc tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac 2580

caaactgaat gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga 2640

tgaggtgaga cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact 2700

gcctgatgac ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt 2760

gggaggcaac tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga 2820

gagggacatc agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg 2880

cttcaactgt tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta 2940

ccaaccatac agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgtg 3000

tggaccaaag aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg 3060

actgacaggc acaggagtgc tgacagagag caacaagaag ttcctgccat tccaacagtt 3120

tggcagggac attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct 3180

ggacatcaca ccatgttcct ttggagggagt gtctgtgatt acacctggca ccaacaccag 3240

caaccaggtg gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca 3300

tgctgaccaa cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac 3360

cagggctggc tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc 3420

aattggagca ggcatctgtg cctcctacca gacccagacc atcctcaggt ctgtggcaag 3480

cccagcatc attgcctaca caatgagtct gggagcagag aactctgtgg cttacagcaa 3540

caacagcatt gccatcccaa ccaacttcac catctctgtg accacagaga ttctgcctgt 3600

gagtatgacc aagacctctg tggactgtac aatgtatatc tgtggagaca gcacagagtg 3660

tagcaacctg ctgctccaat atggctcctt ctgtacccaa cttaacaggg ctctgacagg 3720

cattgctgtg gaacaggaca agaacaccca ggaggtgttt gcccaggtga agcagattta 3780

caagacacct ccaatcaagg actttggagg cttcaacttc agccagattc tgcctgaccc 3840

aagcaagcca agcaagaggt ccttcattga ggacctgctg ttcaacaagg tgaccctggc 3900

tgatgctggc ttcatcaagc aatatggaga ctgtctggga gacattgctg ccagggacct 3960

gatttgtgcc cagaagttca atggactgac agtgctgcct ccactgctga cagatgagat 4020

gattgcccaa tacacctctg ccctgctggc tggcaccatc acctctggct ggacctttgg 4080

agcaggagca gccctccaaa tcccatttgc tatgcagatg gcttacaggt tcaatggcat 4140

tggagtgacc cagaatgtgc tctatgagaa ccagaaactg attgccaacc agttcaactc 4200

tgccattggc aagattcagg actccctgtc cagcacagcc tctgccctgg gcaaactcca 4260

agatgtggtg aaccagaatg cccaggctct gaacaccctg gtgaagcaac tttccagcaa 4320

ctttggagcc atctcctctg tgctgaatga catcctgagc agactggaca aggtggaggc 4380

tgaggtccag attgacagac tgattacagg cagactccaa tccctccaaa cctatgtgac 4440

ccaacaactt atcagggctg ctgagattag ggcatctgcc aacctggctg ccaccaagat 4500

gagtgagtgt gtgctgggac aaagcaagag ggtggacttc tgtggcaagg gctaccacct 4560

gatgagtttt ccacagtctg cccctcatgg agtggtgttc ctgcatgtga cctatgtgcc 4620

tgcccaggag aagaacttca ccacagcccc tgccatctgc catgatggca aggctcactt 4680

tccaagggag ggagtgtttg tgagcaatgg cacccactgg tttgtgaccc agaggaactt 4740

ctatgaacca cagattatca ccacagacaa cacctttgtg tctggcaact gtgatgtggt 4800

gattggcatt gtgaacaaca cagtctatga cccactccaa cctgaactgg actccttcaa 4860

ggaggaactg gacaaatact tcaagaacca caccagccct gatgtggacc tgggagacat 4920

ctctggcatc aatgcctctg tggtgaacat ccagaaggag attgacagac tgaatgaggt 4980

ggctaagaac ctgaatgagt ccctgattga cctccaagaa ctgggcaaat atgaacaata 5040

catcaagtgg ccatggtaca tctggctggg cttcattgct ggactgattg ccattgtgat 5100

ggtgaccata atgctgtgtt gtatgacctc ctgttgttcc tgtctgaaag gctgttgttc 5160

ctgtggctcc tgttgtaagt ttgatgagga tgactctgaa cctgtgctga aaggagtgaa 5220

actgcactac acctgatcta gagcggccgc cgaattcggg cccgtttaaa cccgctgatc 5280

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc 5340

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc 5400

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg 5460

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga 5520

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt 5580

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc 5640

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca 5700

agctctaaat cggggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc 5760

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt 5820

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac 5880

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc 5940

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat 6000

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc 6060

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga 6120

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc 6180

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt 6240

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga 6300

ggcttttttg gaggcctagg cttttgcaaa aagctcccgg gagcttgtat atccattttc 6360

ggatctgatc agcacgtgat gaaaaagcct gaactcaccg cgacgtctgt cgagaagttt 6420

ctgatcgaaa agttcgacag cgtctccgac ctgatgcagc tctcggaggg cgaagaatct 6480

cgtgctttca gcttcgatgt aggagggcgt ggatatgtcc tgcgggtaaa tagctgcgcc 6540

gatggtttct acaaagatcg ttatgtttat cggcactttg catcggccgc gctcccgatt 6600

ccggaagtgc ttgacattgg ggaattcagc gagagcctga cctattgcat ctcccgccgt 6660

gcacaggtg tcacgttgca agacctgcct gaaaccgaac tgcccgctgt tctgcagccg 6720

gtcgcggagg ccatggatgc gatcgctgcg gccgatctta gccagacgag cgggttcggc 6780

ccattcggac cgcaaggaat cggtcaatac actacatggc gtgatttcat atgcgcgatt 6840

gctgatcccc atgtgtatca ctggcaaact gtgatggacg acaccgtcag tgcgtccgtc 6900

gcgcaggctc tcgatgagct gatgctttgg gccgaggact gccccgaagt ccggcacctc 6960

gtgcacgcgg atttcggctc caacaatgtc ctgacggaca atggccgcat aacagcggtc 7020

attgactgga gcgaggcgat gttcggggat tcccaatacg aggtcgccaa catcttcttc 7080

tggaggccgt ggttggcttg tatggagcag cagacgcgct acttcgagcg gaggcatccg 7140

gagcttgcag gatcgccgcg gctccggggcg tatatgctcc gcattggtct tgaccaactc 7200

tatcagagct tggttgacgg caatttcgat gatgcagctt gggcgcaggg tcgatgcgac 7260

gcaatcgtcc gatccggagc cgggactgtc gggcgtacac aaatcgcccg cagaagcgcg 7320

gccgtctgga ccgatggctg tgtagaagta ctcgccgata gtggaaaccg acgccccagc 7380

actcgtccga gggcaaagga atagcacgtg ctacgagatt tcgattccac cgccgccttc 7440

tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc 7500

ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt 7560

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 7620

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc gtcgacctct 7680

agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc 7740

acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga 7800

gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg 7860

tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg 7920

cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg 7980

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga 8040

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg 8100

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag 8160

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc 8220

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg 8280

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt 8340

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc 8400

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc 8460

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg 8520

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca 8580

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc 8640

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct 8700

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg 8760

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt 8820

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt 8880

gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc 8940

gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg 9000

cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc 9060

gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg 9120

gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca 9180

ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga 9240

tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct 9300

ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg 9360

cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca 9420

accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata 9480

cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct 9540

tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact 9600

cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa 9660

acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc 9720

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga 9780

tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga 9840

aaagtgccac ctgacgtc 9858

<210> 3

<211> 3642

<212> DNA

<213> Artificial sequence

<220>

<223> spike protein coding sequence in vector #1

<400> 3

atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc 60

aggacccaac ttcctcctgc ctacaccaac tccttcacca ggggagtcta ctaccctgac 120

aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc 180

aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac 240

aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc 300

atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg 360

aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc 420

ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac 480

tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag 540

ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac 600

ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acaggcttc 660

tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc 720

ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca 780

ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat 840

gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag 900

tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc 960

caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag 1020

gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac 1080

tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat 1140

ggagtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt 1200

gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac 1260

tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac 1320

ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac 1380

ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt 1440

aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc 1500

aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc 1560

cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac 1620

ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg 1680

ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag 1740

accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct 1800

ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg 1860

cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc 1920

aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat 1980

gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaaccca gaccaacagc 2040

ccaaggaggg caaggtctgt ggcaagccag agcatcattg cctacacaat gagtctggga 2100

gcagagaact ctgtggctta cagcaacaac agcattgcca tcccaaccaa cttcaccatc 2160

tctgtgacca cagagattct gcctgtgagt atgaccaaga cctctgtgga ctgtacaatg 2220

tatatctgtg gagacagcac agagtgtagc aacctgctgc tccaatatgg ctccttctgt 2280

acccaactta acagggctct gacaggcatt gctgtggaac aggacaagaa cacccaggag 2340

gtgtttgccc aggtgaagca gatttacaag acacctccaa tcaaggactt tggaggcttc 2400

aacttcagcc agattctgcc tgacccaagc aagccaagca agaggtcctt cattgaggac 2460

ctgctgttca acaaggtgac cctggctgat gctggcttca tcaagcaata tggagactgt 2520

ctggggagaca ttgctgccag ggacctgatt tgtgcccaga agttcaatgg actgacagtg 2580

ctgcctccac tgctgacaga tgagatgatt gcccaataca cctctgccct gctggctggc 2640

accatcacct ctggctggac ctttggagca ggagcagccc tccaaatccc atttgctatg 2700

cagatggctt acaggttcaa tggcattgga gtgacccaga atgtgctcta tgagaaccag 2760

aaactgattg ccaaccagtt caactctgcc attggcaaga ttcaggactc cctgtccagc 2820

acagcctctg ccctgggcaa actccaagat gtggtgaacc agaatgccca ggctctgaac 2880

accctggtga agcaactttc cagcaacttt ggagccatct cctctgtgct gaatgacatc 2940

ctgagcagac tggacaaggt ggaggctgag gtccagattg acagactgat tacaggcaga 3000

ctccaatccc tccaaaccta tgtgacccaa caacttatca gggctgctga gattagggca 3060

tctgccaacc tggctgccac caagatgagt gagtgtgtgc tgggacaaag caagaggtg 3120

gacttctgtg gcaagggcta ccacctgatg agttttccac agtctgcccc tcatggagtg 3180

gtgttcctgc atgtgaccta tgtgcctgcc caggagaaga acttcaccac agcccctgcc 3240

atctgccatg atggcaaggc tcactttcca agggagggag tgtttgtgag caatggcacc 3300

cactggtttg tgacccagag gaacttctat gaaccacaga ttatcaccac agacaacacc 3360

tttgtgtctg gcaactgtga tgtggtgatt ggcattgtga acaacacagt ctatgaccca 3420

ctccaacctg aactggactc cttcaaggag gaactggaca aatacttcaa gaaccacacc 3480

agccctgatg tggacctggg agacatctct ggcatcaatg cctctgtggt gaacatccag 3540

aaggagattg acagactgaa tgaggtggct aagaacctga atgagtccct gattgacctc 3600

caagaactgg gcaaatatga acaatacatc aagtggccat ga 3642

<210> 4

<211> 37

<212> DNA

<213> Artificial sequence

<220>

<223> direct primer of the spike protein gene

<400> 4

tccagcctcc gatttgccac catgtttgtg ttcctgg 37

<210> 5

<211> 39

<212> DNA

<213> Artificial sequence

<220>

<223> reverse primer of the spike protein gene

<400> 5

gattatgatc aattttcatg gccacttgat gtattgttc 39

<210> 6

<211> 24

<212> DNA

<213> Artificial sequence

<220>

<223> S1/S2 cleavage site

<400> 6

acgaattctc ctcggcgggc acgt 24

<210> 7

<211> 12

<212> DNA

<213> Artificial sequence

<220>

<223> linker

<400> 7

acgatcctcc gt 12

<210> 8

<211> 3630

<212> DNA

<213> Artificial sequence

<220>

<223> spike protein coding sequence in vector #2

<400> 8

atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc 60

aggacccaac ttcctcctgc ctacaccaac tccttcacca ggggagtcta ctaccctgac 120

aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc 180

aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac 240

aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc 300

atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg 360

aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc 420

ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac 480

tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag 540

ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac 600

ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acaggcttc 660

tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc 720

ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca 780

ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat 840

gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag 900

tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc 960

caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag 1020

gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac 1080

tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat 1140

ggagtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt 1200

gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac 1260

tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac 1320

ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac 1380

ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt 1440

aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc 1500

aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc 1560

cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac 1620

ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg 1680

ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag 1740

accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct 1800

ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg 1860

cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc 1920

aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat 1980

gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaaccca gaccatcctc 2040

aggtctgtgg caagccagag catcattgcc tacacaatga gtctgggagc agagaactct 2100

gtggcttaca gcaacaacag cattgccatc ccaaccaact tcaccatctc tgtgaccaca 2160

gagatctgc ctgtgagtat gaccaagacc tctgtggact gtacaatgta tatctgtgga 2220

gacagcacag agtgtagcaa cctgctgctc caatatggct ccttctgtac ccaacttaac 2280

agggctctga caggcattgc tgtggaacag gacaagaaca cccaggaggt gtttgcccag 2340

gtgaagcaga tttacaagac acctccaatc aaggactttg gaggcttcaa cttcagccag 2400

attctgcctg acccaagcaa gccaagcaag aggtccttca ttgaggacct gctgttcaac 2460

aaggtgaccc tggctgatgc tggcttcatc aagcaatatg gagactgtct gggagacatt 2520

gctgccaggg acctgatttg tgcccagaag ttcaatggac tgacagtgct gcctccactg 2580

ctgacagatg agatgattgc ccaatacacc tctgccctgc tggctggcac catcacctct 2640

ggctggacct ttggagcagg agcagccctc caaatcccat ttgctatgca gatggcttac 2700

aggttcaatg gcattggagt gacccagaat gtgctctatg agaaccagaa actgattgcc 2760

aaccagttca actctgccat tggcaagatt caggactccc tgtccagcac agcctctgcc 2820

ctgggcaaac tccaagatgt ggtgaaccag aatgcccagg ctctgaacac cctggtgaag 2880

caactttcca gcaactttgg agccatctcc tctgtgctga atgacatcct gagcagactg 2940

gacaaggtgg aggctgaggt ccagattgac agactgatta caggcagact ccaatccctc 3000

caaacctatg tgacccaaca acttatcagg gctgctgaga ttagggcatc tgccaacctg 3060

gctgccacca agatgagtga gtgtgtgctg ggacaaagca agaggtgga cttctgtggc 3120

aagggctacc acctgatgag ttttccacag tctgcccctc atggagtggt gttcctgcat 3180

gtgacctatg tgcctgccca ggagaagaac ttcaccacag cccctgccat ctgccatgat 3240

ggcaaggctc actttccaag ggagggagtg tttgtgagca atggcaccca ctggtttgtg 3300

acccagagga acttctatga acccacagatt atcaccacag acaacacctt tgtgtctggc 3360

aactgtgatg tggtgattgg cattgtgaac aacacagtct atgacccact ccaacctgaa 3420

ctggactcct tcaagggagga actggacaaa tacttcaaga accacaccag ccctgatgtg 3480

gacctgggag acatctctgg catcaatgcc tctgtggtga acatccagaa ggagattgac 3540

agactgaatg aggtggctaa gaacctgaat gagtccctga ttgacctcca agaactgggc 3600

aaatatgaac aatacatcaa gtggccatga 3630

<210> 9

<211> 31

<212> DNA

<213> Artificial sequence

<220>

<223> forward primer

<400> 9

agaccatcct caggtctgtg gcaagccaga g 31

<210> 10

<211> 30

<212> DNA

<213> Artificial sequence

<220>

<223> reverse primer

<400> 10

cctcctacca gacccagacc atcctcaggt 30

<210> 11

<211> 27

<212> DNA

<213> Artificial sequence

<220>

<223> linker

<400> 11

accggtggcg gtgggtcgag gtctgtg 27

<210> 12

<211> 3639

<212> DNA

<213> Artificial sequence

<220>

<223> spike protein coding sequence in vector #3

<400> 12

atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc 60

aggacccaac ttcctcctgc ctacaccaac tccttcacca ggggagtcta ctaccctgac 120

aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc 180

aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac 240

aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc 300

atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg 360

aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc 420

ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac 480

tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag 540

ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac 600

ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acaggcttc 660

tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc 720

ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca 780

ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat 840

gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag 900

tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc 960

caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag 1020

gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac 1080

tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat 1140

ggagtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt 1200

gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac 1260

tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac 1320

ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac 1380

ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt 1440

aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc 1500

aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc 1560

cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac 1620

ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg 1680

ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag 1740

accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct 1800

ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg 1860

cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc 1920

aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat 1980

gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaaccca gaccggtggc 2040

ggtgggtcga ggtctgtggc aagccagagc atcattgcct acacaatgag tctgggagca 2100

gagaactctg tggcttacag caacaacagc attgccatcc caaccaactt caccatctct 2160

gtgaccacag agattctgcc tgtgagtatg accaagacct ctgtggactg tacaatgtat 2220

atctgtggag acagcacaga gtgtagcaac ctgctgctcc aatatggctc cttctgtacc 2280

caacttaaca gggctctgac aggcattgct gtggaacagg acaagaacac cccaggaggtg 2340

tttgcccagg tgaagcagat ttacaagaca cctccaatca aggactttgg aggcttcaac 2400

ttcagccaga ttctgcctga cccaagcaag ccaagcaaga ggtccttcat tgaggacctg 2460

ctgttcaaca aggtgaccct ggctgatgct ggcttcatca agcaatatgg agactgtctg 2520

ggagacattg ctgccaggga cctgatttgt gcccagaagt tcaatggact gacagtgctg 2580

cctccactgc tgacagatga gatgattgcc caatacacct ctgccctgct ggctggcacc 2640

atcacctctg gctggacctt tggagcagga gcagccctcc aaatcccatt tgctatgcag 2700

atggcttaca ggttcaatgg cattggagtg acccagaatg tgctctatga gaaccagaaa 2760

ctgattgcca accagttcaa ctctgccatt ggcaagattc aggactccct gtccagcaca 2820

gcctctgccc tgggcaaact ccaagatgtg gtgaaccaga atgcccaggc tctgaacacc 2880

ctggtgaagc aactttccag caactttgga gccatctcct ctgtgctgaa tgacatcctg 2940

agcagactgg acaaggtgga ggctgaggtc cagattgaca gactgattac aggcagactc 3000

caatccctcc aaacctatgt gacccaacaa cttatcaggg ctgctgagat tagggcatct 3060

gccaacctgg ctgccaccaa gatgagtgag tgtgtgctgg gacaaagcaa gagggtggac 3120

ttctgtggca agggctacca cctgatgagt tttccacagt ctgcccctca tggagtggtg 3180

ttcctgcatg tgacctatgt gcctgcccag gagaagaact tcaccacagc ccctgccatc 3240

tgccatgatg gcaaggctca ctttccaagg gagggagtgt ttgtgagcaa tggcaccac 3300

tggtttgtga cccagaggaa cttctatgaa cccagatta tcaccacaga caacaccttt 3360

gtgtctggca actgtgatgt ggtgattggc attgtgaaca acacagtcta tgacccactc 3420

caacctgaac tggactcctt caaggaggaa ctggacaaat acttcaagaa ccacaccagc 3480

cctgatgtgg acctgggaga catctctggc atcaatgcct ctgtggtgaa catccagaag 3540

gagattgaca gactgaatga ggtggctaag aacctgaatg agtccctgat tgacctccaa 3600

gaactgggca aatatgaaca atacatcaag tggccatga 3639

<210> 13

<211> 36

<212> DNA

<213> Artificial sequence

<220>

<223> forward primer

<400> 13

cggtggcggt gggtcgaggt ctgtggcaag ccagag 36

<210> 14

<211> 34

<212> DNA

<213> Artificial sequence

<220>

<223> reverse primer

<400> 14

gacccaccgc caccggtctg ggtctggtag gagg 34

<210> 15

<211> 57

<212> DNA

<213> Artificial sequence

<220>

<223> linker

<400> 15

accggtggcg gtgggtcggg cggtggtggg tcgggtggcg gcggttccag gtctgtg 57

<210> 16

<211> 3669

<212> DNA

<213> Artificial sequence

<220>

<223> spike protein coding sequence in vector #4

<400> 16

atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc 60

aggacccaac ttcctcctgc ctacaccaac tccttcacca ggggagtcta ctaccctgac 120

aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc 180

aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac 240

aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc 300

atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg 360

aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc 420

ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac 480

tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag 540

ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac 600

ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acaggcttc 660

tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc 720

ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca 780

ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat 840

gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag 900

tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc 960

caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag 1020

gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac 1080

tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat 1140

ggagtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt 1200

gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac 1260

tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac 1320

ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac 1380

ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt 1440

aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc 1500

aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc 1560

cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac 1620

ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg 1680

ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag 1740

accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct 1800

ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg 1860

cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc 1920

aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat 1980

gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaaccca gaccggtggc 2040

ggtgggtcgg gcggtggtgg gtcgggtggc ggcggttcca ggtctgtggc aagccagagc 2100

atcattgcct acacaatgag tctgggagca gagaactctg tggcttacag caacaacagc 2160

attgccatcc caaccaactt caccatctct gtgaccacag agattctgcc tgtgagtatg 2220

accaagacct ctgtggactg tacaatgtat atctgtggag acagcacaga gtgtagcaac 2280

ctgctgctcc aatatggctc cttctgtacc caacttaaca gggctctgac aggcattgct 2340

gtggaacagg acaagaacac ccaggaggtg tttgcccagg tgaagcagat ttacaagaca 2400

cctccaatca aggactttgg aggcttcaac ttcagccaga ttctgcctga cccaagcaag 2460

ccaagcaaga ggtccttcat tgaggacctg ctgttcaaca aggtgaccct ggctgatgct 2520

ggcttcatca agcaatatgg agactgtctg ggagacattg ctgccaggga cctgatttgt 2580

gcccagaagt tcaatggact gacagtgctg cctccactgc tgacagatga gatgattgcc 2640

caatacacct ctgccctgct ggctggcacc atcacctctg gctggacctt tggagcagga 2700

gcagccctcc aaatcccatt tgctatgcag atggcttaca ggttcaatgg cattggagtg 2760

acccagaatg tgctctatga gaaccagaaa ctgattgcca accagttcaa ctctgccatt 2820

ggcaagattc aggactccct gtccagcaca gcctctgccc tgggcaaact ccaagatgtg 2880

gtgaaccaga atgcccaggc tctgaacacc ctggtgaagc aactttccag caactttgga 2940

gccatctcct ctgtgctgaa tgacatcctg agcagactgg acaaggtgga ggctgaggtc 3000

cagattgaca gactgattac aggcagactc caatccctcc aaacctatgt gacccaacaa 3060

cttatcaggg ctgctgagat tagggcatct gccaacctgg ctgccaccaa gatgagtgag 3120

tgtgtgctgg gacaaagcaa gagggtggac ttctgtggca agggctacca cctgatgagt 3180

tttccacagt ctgcccctca tggagtggtg ttcctgcatg tgacctatgt gcctgcccag 3240

gagaagaact tcaccacagc ccctgccatc tgccatgatg gcaaggctca ctttccaagg 3300

gagggagtgt ttgtgagcaa tggcacccac tggtttgtga cccagaggaa cttctatgaa 3360

ccacagatta tcaccacaga caacaccttt gtgtctggca actgtgatgt ggtgattggc 3420

attgtgaaca acacagtcta tgacccactc caacctgaac tggactcctt caagggaggaa 3480

ctggacaaat acttcaagaa ccacaccagc cctgatgtgg acctgggaga catctctggc 3540

atcaatgcct ctgtggtgaa catccagaag gagattgaca gactgaatga ggtggctaag 3600

aacctgaatg agtccctgat tgacctccaa gaactgggca aatatgaaca atacatcaag 3660

tggccatga 3669

<210> 17

<211> 51

<212> DNA

<213> Artificial sequence

<220>

<223> forward primer

<400> 17

gggcggtggt gggtcgggtg gcggcggttc caggtctgtg gcaagccaga g 51

<210> 18

<211> 49

<212> DNA

<213> Artificial sequence

<220>

<223> reverse primer

<400> 18

gacccaccac cgcccgaccc accgccaccg gtctgggtct ggtaggagg 49

<210> 19

<211> 7

<212>PRT

<213> Artificial sequence

<220>

<223> linker #3

<400> 19

Thr Gly Gly Gly Gly Ser Arg

15

<210> 20

<211> 9

<212>PRT

<213> Artificial sequence

<220>

<223> linker #4

<400> 20

Thr Gly Gly Gly Gly Ser Arg Arg Arg

15

<210> 21

<211> 31091

<212> DNA

<213> Artificial sequence

<220>

<223> Adk35F

<400> 21

catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tactgtaata gtaatcaatt 360

acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420

ggcccgcctg gctgaccgcc caacgacccc cgcccatga cgtcaataat gacgtatgtt 480

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660

acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720

tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt 780

gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840

aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900

agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020

agacaccggg accgatccag cctccgattt aaattgatca taatcagcca taccacattt 1080

gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 1140

atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc 1200

aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 1260

tccaaactca tcaatgtatc ttaacgcgga tctgggcgtg gttaagggtg ggaaagaata 1320

tataaggtgg gggtcttatg tagttttgta tctgttttgc agcagccgcc gccgccatga 1380

gcaccaactc gtttgatgga agcattgtga gctcatattt gacaacgcgc atgcccccat 1440

gggccggggt gcgtcagaat gtgatgggct ccagcattga tggtcgcccc gtcctgcccg 1500

caaactctac taccttgacc tacgagaccg tgtctggaac gccgttggag actgcagcct 1560

ccgccgccgc ttcagccgct gcagccaccg cccgcgggat tgtgactgac tttgctttcc 1620

tgagcccgct tgcaagcagt gcagcttccc gttcatccgc ccgcgatgac aagttgacgg 1680

ctcttttggc acaattggat tctttgaccc gggaacttaa tgtcgtttct cagcagctgt 1740

tggatctgcg ccagcaggtt tctgccctga aggcttcctc ccctcccaat gcggtttaaa 1800

acataaataa aaaaccagac tctgtttgga tttggatcaa gcaagtgtct tgctgtcttt 1860

atttaggggt tttgcgcgcg cggtaggccc gggaccagcg gtctcggtcg ttgaggtcc 1920

tgtgtatttt ttccaggacg tggtaaaggt gactctggat gttcagatac atgggcataa 1980

gcccgtctct ggggtggagg tagcaccact gcagagcttc atgctgcggg gtggtgttgt 2040

agatgatcca gtcgtagcag gagcgctggg cgtggtgcct aaaaatgtct ttcagtagca 2100

agctgattgc caggggcagg cccttggtgt aagtgtttac aaagcggtta agctgggatg 2160

ggtgcatacg tggggatatg agatgcatct tggactgtat ttttaggttg gctatgttcc 2220

cagccatatc cctccgggga ttcatgttgt gcagaaccac cagcacagtg tatccggtgc 2280

acttgggaaa tttgtcatgt agcttagaag gaaatgcgtg gaagaacttg gagacgccct 2340

tgtgacctcc aagattttcc atgcattcgt ccataatgat ggcaatgggc ccacgggcgg 2400

cggcctgggc gaagatattt ctgggatcac taacgtcata gttgtgttcc aggatgagat 2460

cgtcataggc catttttaca aagcgcgggc ggagggtgcc agactgcggt ataatggttc 2520

catccggccc aggggcgtag ttaccctcac agatttgcat ttcccacgct ttgagttcag 2580

atggggggat catgtctacc tgcggggcga tgaagaaaac ggtttccggg gtaggggaga 2640

tcagctggga agaaagcagg ttcctgagca gctgcgactt accgcagccg gtgggcccgt 2700

aaatcacacc tattaccggc tgcaactggt agttaagaga gctgcagctg ccgtcatccc 2760

tgagcagggg ggccacttcg ttaagcatgt ccctgactcg catgttttcc ctgaccaaat 2820

ccgccagaag gcgctcgccg cccagcgata gcagttcttg caaggaagca aagtttttca 2880

acggtttgag accgtccgcc gtaggcatgc ttttgagcgt ttgaccaagc agttccaggc 2940

ggtcccacag ctcggtcacc tgctctacgg catctcgatc cagcatatct cctcgtttcg 3000

cgggttgggg cggctttcgc tgtacggcag tagtcggtgc tcgtccagac gggccagggt 3060

catgtctttc cacgggcgca gggtcctcgt cagcgtagtc tgggtcacgg tgaaggggtg 3120

cgctccgggc tgcgcgctgg ccagggtgcg cttgaggctg gtcctgctgg tgctgaagcg 3180

ctgccggtct tcgccctgcg cgtcggccag gtagcatttg accatggtgt catagtccag 3240

cccctccgcg gcgtggccct tggcgcgcag cttgcccttg gaggaggcgc cgcacgaggg 3300

gcagtgcaga cttttgaggg cgtagagctt gggcgcgaga aataccgatt ccggggagta 3360

ggcatccgcg ccgcaggccc cgcagacggt ctcgcattcc acgagccagg tgagctctgg 3420

ccgttcgggg tcaaaaacca ggtttccccc atgctttttg atgcgtttct tacctctggt 3480

ttccatgagc cggtgtccac gctcggtgac gaaaaggctg tccgtgtccc cgtatacaga 3540

cttgagaggc ctgtcctcga gcggtgttcc gcggtcctcc tcgtatagaa actcggacca 3600

ctctgagaca aaggctcgcg tccaggccag cacgaaggag gctaagtggg aggggtagcg 3660

gtcgttgtcc actagggggt ccactcgctc cagggtgtga agacacatgt cgccctcttc 3720

ggcatcaagg aaggtgattg gtttgtaggt gtaggccacg tgaccgggtg ttcctgaagg 3780

ggggctataa aagggggtgg gggcgcgttc gtcctcactc tcttccgcat cgctgtctgc 3840

gagggccagc tgttggggtg agtactccct ctgaaaagcg ggcatgactt ctgcgctaag 3900

attgtcagtt tccaaaaacg aggaggattt gatattcacc tggcccgcgg tgatgccttt 3960

gagggtggcc gcatccatct ggtcagaaaa gacaatcttt ttgttgtcaa gcttggtggc 4020

aaacgacccg tagagggcgt tggacagcaa cttggcgatg gagcgcaggg tttggttttt 4080

gtcgcgatcg gcgcgctcct tggccgcgat gtttagctgc acgtattcgc gcgcaacgca 4140

ccgccattcg ggaaagacgg tggtgcgctc gtcgggcacc aggtgcacgc gccaaccgcg 4200

gttgtgcagg gtgacaaggt caacgctggt ggctacctct ccgcgtaggc gctcgttggt 4260

ccagcagagg cggccgccct tgcgcgagca gaatggcggt agggggtcta gctgcgtctc 4320

gtccgggggg tctgcgtcca cggtaaagac cccgggcagc aggcgcgcgt cgaagtagtc 4380

tatcttgcat ccttgcaagt ctagcgcctg ctgccatgcg cgggcggcaa gcgcgcgctc 4440

gtatgggttg agtgggggac cccatggcat ggggtggggtg agcgcggagg cgtacatgcc 4500

gcaaatgtcg taaacgtaga ggggctctct gagtattcca agatatgtag ggtagcatct 4560

tccaccgcgg atgctggcgc gcacgtaatc gtatagttcg tgcgagggag cgaggaggtc 4620

gggaccgagg ttgctacggg cgggctgctc tgctcggaag actatctgcc tgaagatggc 4680

atgtgagttg gatgatatgg ttggacgctg gaagacgttg aagctggcgt ctgtgagacc 4740

taccgcgtca cgcacgaagg aggcgtagga gtcgcgcagc ttgttgacca gctcggcggt 4800

gacctgcacg tctaggcgc agtagtccag ggtttccttg atgatgtcat acttatcctg 4860

tccctttttt ttccacagct cgcggttgag gacaaactct tcgcggtctt tccagtactc 4920

ttggatcgga aacccgtcgg cctccgaacg gtaagagcct agcatgtaga actggttgac 4980

ggcctggtag gcgcagcatc ccttttctac gggtagcgcg tatgcctgcg cggccttccg 5040

gagcgaggtg tgggtgagcg caaaggtgtc cctgaccatg actttgaggt actggtattt 5100

gaagtcagtg tcgtcgcatc cgccctgctc cccagcaaa aagtccgtgc gctttttgga 5160

acgcggattt ggcagggcga aggtgacatc gttgaagagt atctttcccg cgcgaggcat 5220

aaagttgcgt gtgatgcgga agggtcccgg cacctcggaa cggttgttaa ttacctgggc 5280

ggcgagcacg atctcgtcaa agccgttgat gttgtggccc acaatgtaaa gttccaagaa 5340

gcgcgggatg cccttgatgg aaggcaattt tttaagttcc tcgtaggtga gctcttcagg 5400

ggagctgagc ccgtgctctg aaagggccca gtctgcaaga tgaggttgg aagcgacgaa 5460

tgagctccac aggtcacggg ccattagcat ttgcaggtgg tcgcgaaagg tcctaaactg 5520

gcgacctatg gccatttttt ctggggtgat gcagtagaag gtaagcgggt cttgttccca 5580

gcggtcccat ccaaggttcg cggctaggtc tcgcgcggca gtcactagag gctcatctcc 5640

gccgaacttc atgaccagca tgaagggcac gagctgcttc ccaaaggccc ccatccaagt 5700

ataggtctct acatcgtagg tgacaaagag acgctcggtg cgaggatgcg agccgatcgg 5760

gaagaactgg atctcccgcc accaattgga ggagtggcta ttgatgtggt gaaagtagaa 5820

gtccctgcga cgggccgaac actcgtgctg gcttttgtaa aaacgtgcgc agtactggca 5880

gcggtgcacg ggctgtacat cctgcacgag gttgacctga cgaccgcgca caaggaagca 5940

gagtgggaat ttgagcccct cgcctggcgg gtttggctgg tggtcttcta cttcggctgc 6000

ttgtccttga ccgtctggct gctcgagggg agttacggtg gatcggacca ccacgccgcg 6060

cgagcccaaa gtccagatgt ccgcgcgcgg cggtcggagc ttgatgacaa catcgcgcag 6120

atgggagctg tccatggtct ggagctcccg cggcgtcagg tcaggcggga gctcctgcag 6180

gtttacctcg catagacggg tcagggcgcg ggctagatcc aggtgatacc taatttccag 6240

gggctggttg gtggcggcgt cgatggcttg caagaggccg catccccgcg gcgcgactac 6300

ggtaccgcgc ggcgggcggt gggccgcggg ggtgtccttg gatgatgcat ctaaaagcgg 6360

tgacgcgggc gagcccccgg aggtaggggg ggctccggac ccgccgggag agggggcagg 6420

ggcacgtcgg cgccgcgcgc gggcaggagc tggtgctgcg cgcgtaggtt gctggcgaac 6480

gcgacgacgc ggcggttgat ctcctgaatc tggcgcctct gcgtgaagac gacgggcccg 6540

gtgagcttga acctgaaaga gagttcgaca gaatcaattt cggtgtcgtt gacggcggcc 6600

tggcgcaaaa tctcctgcac gtctcctgag ttgtcttgat aggcgatctc ggccatgaac 6660

tgctcgatct cttcctcctg gagatctccg cgtccggctc gctccacggt ggcggcgagg 6720

tcgttggaaa tgcgggccat gagctgcgag aaggcgttga ggcctccctc gttccagacg 6780

cggctgtaga ccacgccccc ttcggcatcg cgggcgcgca tgaccacctg cgcgagattg 6840

agctccacgt gccgggcgaa gacggcgtag tttcgcaggc gctgaaagag gtagttgagg 6900

gtggtggcgg tgtgttctgc cacgaagaag tacataaccc agcgtcgcaa cgtggattcg 6960

ttgatatccc ccaaggcctc aaggcgctcc atggcctcgt agaagtccac ggcgaagttg 7020

aaaaactggg agttgcgcgc cgacacggtt aactcctcct ccagaagacg gatgagctcg 7080

gcgacagtgt cgcgcacctc gcgctcaaag gctacagggg cctcttcttc ttcttcaatc 7140

tcctcttcca taagggcctc cccttcttct tcttctggcg gcggtggggg aggggggaca 7200

cggcggcgac gacggcgcac cgggaggcgg tcgacaaagc gctcgatcat ctccccgcgg 7260

cgacggcgca tggtctcggt gacggcgcgg ccgttctcgc gggggcgcag ttggaagacg 7320

ccgcccgtca tgtcccggtt atgggttggc ggggggctgc catgcggcag ggatacggcg 7380

ctaacgatgc atctcaacaa ttgttgtgta ggtactccgc cgccgaggga cctgagcgag 7440

tccgcatcga ccggatcgga aaacctctcg agaaaggcgt ctaaccagtc acagtcgcaa 7500

ggtaggctga gcaccgtggc gggcggcagc gggcggcggt cggggttgtt tctggcggag 7560

gtgctgctga tgatgtaatt aaagtaggcg gtcttgagac ggcggatggt cgacagaagc 7620

accatgtcct tgggtccggc ctgctgaatg cgcaggcggt cggccatgcc ccaggcttcg 7680

ttttgacatc ggcgcaggtc tttgtagtag tcttgcatga gcctttctac cggcacttct 7740

tcttctcctt cctcttgtcc tgcatctctt gcatctatcg ctgcggcggc ggcggagttt 7800

ggccgtaggt ggcgccctct tcctcccatg cgtgtgaccc cgaagcccct catcggctga 7860

agcagggcta ggtcggcgac aacgcgctcg gctaatatgg cctgctgcac ctgcgtgagg 7920

gtagactgga agtcatccat gtccacaaag cggtggtatg cgcccgtgtt gatggtgtaa 7980

gtgcagttgg ccataacgga ccagttaacg gtctggtgac ccggctgcga gagctcggtg 8040

tacctgagac gcgagtaagc cctcgagtca aatacgtagt cgttgcaagt ccgcaccagg 8100

tactggtatc ccaccaaaaa gtgcggcggc ggctggcggt agaggggcca gcgtagggtg 8160

gccggggctc cggggggcgag atcttccaac ataaggcgat gatatccgta gatgtacctg 8220

gacatccagg tgatgccggc ggcggtggtg gaggcgcgcg gaaagtcgcg gacgcggttc 8280

cagatgttgc gcagcggcaa aaagtgctcc atggtcggga cgctctggcc ggtcaggcgc 8340

gcgcaatcgt tgacgctcta gcgtgcaaaa ggagagcctg taagcgggca ctcttccgtg 8400

gtctggtgga taaattcgca agggtatcat ggcggacgac cggggttcga gccccgtatc 8460

cggccgtccg ccgtgatcca tgcggttacc gcccgcgtgt cgaacccagg tgtgcgacgt 8520

cagacaacgg gggagtgctc cttttggctt ccttccaggc gcggcggctg ctgcgctagc 8580

ttttttggcc actggccgcg cgcagcgtaa gcggttaggc tggaaagcga aagcattaag 8640

tggctcgctc cctgtagccg gagggttatt ttccaagggt tgagtcgcgg gacccccggt 8700

tcgagtctcg gaccggccgg actgcggcga acggggggttt gcctccccgt catgcaagac 8760

cccgcttgca aattcctccg gaaacaggga cgagcccctt ttttgctttt cccagatgca 8820

tccggtgctg cggcagatgc gcccccctcc tcagcagcgg caagagcaag agcagcggca 8880

gacatgcagg gcaccctccc ctcctcctac cgcgtcagga ggggcgacat ccgcggttga 8940

cgcggcagca gatggtgatt acgaaccccc gcggcgccgg gcccggcact acctggactt 9000

ggagggagggc gagggcctgg cgcggctagg agcgccctct cctgagcggc acccaagggt 9060

gcagctgaag cgtgatacgc gtgaggcgta cgtgccgcgg cagaacctgt ttcgcgaccg 9120

cgaggggagag gagcccgagg agatgcggga tcgaaagttc cacgcagggc gcgagctgcg 9180

gcatggcctg aatcgcgagc ggttgctgcg cgaggaggac tttgagcccg acgcgcgaac 9240

cgggattagt cccgcgcgcg cacacgtggc ggccgccgac ctggtaaccg catacgagca 9300

gacggtgaac caggagatta actttcaaaa aagctttaac aaccacgtgc gtacgcttgt 9360

ggcgcgcgag gaggtggcta taggactgat gcatctgtgg gactttgtaa gcgcgctgga 9420

gcaaaaccca aatagcaagc cgctcatggc gcagctgttc cttatagtgc agcacagcag 9480

ggacaacgag gcattcaggg atgcgctgct aaacatagta gagcccgagg gccgctggct 9540

gctcgatttg ataaacatcc tgcagagcat agtggtgcag gagcgcagct tgagcctggc 9600

tgacaaggtg gccgccatca actattccat gcttagcctg ggcaagtttt acgcccgcaa 9660

gatataccat accccttacg ttcccataga caaggaggta aagatcgagg ggttctacat 9720

gcgcatggcg ctgaaggtgc ttaccttgag cgacgacctg ggcgtttatc gcaacgagcg 9780

catccacaag gccgtgagcg tgagccggcg gcgcgagctc agcgaccgcg agctgatgca 9840

cagcctgcaa agggccctgg ctggcacggg cagcggcgat agagaggccg agtcctactt 9900

tgacgcgggc gctgacctgc gctgggcccc aagccgacgc gccctggagg cagctggggc 9960

cggacctggg ctggcggtgg cacccgcgcg cgctggcaac gtcggcggcg tggaggaata 10020

tgacgaggac gatgagtacg agccagagga cggcgagtac taagcggtga tgtttctgat 10080

cagatgatgc aagacgcaac ggacccggcg gtgcgggcgg cgctgcagag ccagccgtcc 10140

ggccttaact ccacggacga ctggcgccag gtcatggacc gcatcatgtc gctgactgcg 10200

cgcaatcctg acgcgttccg gcagcagccg caggccaacc ggctctccgc aattctggaa 10260

gcggtggtcc cggcgcgcgc aaaccccacg cacgagaagg tgctggcgat cgtaaacgcg 10320

ctggccgaaa acagggccat ccggcccgac gaggccggcc tggtctacga cgcgctgctt 10380

cagcgcgtgg ctcgttacaa cagcggcaac gtgcagacca acctggaccg gctggtgggg 10440

gatgtgcgcg aggccgtggc gcagcgtgag cgcgcgcagc agcagggcaa cctgggctcc 10500

atggttgcac taaacgcctt cctgagtaca cagcccgcca acgtgccgcg gggacaggag 10560

gactacacca actttgtgag cgcactgcgg ctaatggtga ctgagacacc gcaaagtgag 10620

gtgtaccagt ctgggccaga ctattttttc cagaccagta gacaaggcct gcagaccgta 10680

aacctgagcc aggctttcaa aaacttgcag gggctgtggg gggtgcgggc tcccacaggc 10740

gaccgcgcga ccgtgtctag cttgctgacg cccaactcgc gcctgttgct gctgctaata 10800

gcgcccttca cggacagtgg cagcgtgtcc cgggacacat acctaggtca cttgctgaca 10860

ctgtaccgcg aggccatagg tcaggcgcat gtggacgagc atactttcca ggagattaca 10920

agtgtcagcc gcgcgctggg gcaggaggac acgggcagcc tggaggcaac cctaaactac 10980

ctgctgacca accggcggca gaagatcccc tcgttgcaca gtttaaacag cgaggaggag 11040

cgcattttgc gctacgtgca gcagagcgtg agccttaacc tgatgcgcga cggggtaacg 11100

cccagcgtgg cgctggacat gaccgcgcgc aacatggaac cgggcatgta tgcctcaaac 11160

cggccgttta tcaaccgcct aatggactac ttgcatcgcg cggccgccgt gaaccccgag 11220

tatttcacca atgccatctt gaacccgcac tggctaccgc cccctggttt ctacaccggg 11280

ggattcgagg tgcccgaggg taacgatgga ttcctctggg acgacataga cgacagcgtg 11340

ttttccccgc aaccgcagac cctgctagag ttgcaacagc gcgagcaggc agaggcggcg 11400

ctgcgaaagg aaagcttccg caggccaagc agcttgtccg atctaggcgc tgcggccccg 11460

cggtcagatg ctagtagccc atttccaagc ttgatagggt ctcttaccag cactcgcacc 11520

acccgcccgc gcctgctggg cgaggaggag tacctaaaca actcgctgct gcagccgcag 11580

cgcgaaaaaa acctgcctcc ggcatttccc aacaacggga tagagagcct agtggacaag 11640

atgagtagat ggaagacgta cgcgcaggag cacagggacg tgccaggccc gcgcccgccc 11700

acccgtcgtc aaaggcacga ccgtcagcgg ggtctggtgt gggaggacga tgactcggca 11760

gacgacagca gcgtcctgga tttgggagg agtggcaacc cgtttgcgca ccttcgcccc 11820

aggctgggga gaatgtttta aaaaaaaaaa agcatgatgc aaaataaaaa actcaccaag 11880

gccatggcac cgagcgttgg ttttcttgta ttccccttag tatgcggcgc gcggcgatgt 11940

atgaggaagg tcctcctccc tcctacgaga gtgtggtgag cgcggcgcca gtggcggcgg 12000

cgctgggttc tcccttcgat gctcccctgg acccgccgtt tgtgcctccg cggtacctgc 12060

ggcctaccgg ggggagaaac agcatccgtt actctgagtt ggcaccccta ttcgacacca 12120

cccgtgtgta cctggtggac aacaagtcaa cggatgtggc atccctgaac taccagaacg 12180

acccacagcaa ctttctgacc acggtcattc aaaacaatga ctacagcccg ggggaggcaa 12240

gcacacagac catcaatctt gacgaccggt cgcactgggg cggcgacctg aaaaccatcc 12300

tgcataccaa catgccaaat gtgaacgagt tcatgtttac caataagttt aaggcgcggg 12360

tgatggtgtc gcgcttgcct actaaggaca atcaggtgga gctgaaatac gagtgggtgg 12420

agttcacgct gcccgagggc aactactccg agaccatgac catagacctt atgaacaacg 12480

cgatcgtgga gcactacttg aaagtgggca gacagaacgg ggttctggaa agcgacatcg 12540

gggtaaagtt tgacacccgc aacttcagac tggggtttga ccccgtcact ggtcttgtca 12600

tgcctggggt atatacaaac gaagccttcc atccagacat cattttgctg ccaggatgcg 12660

gggtggactt cacccacagc cgcctgagca acttgttggg catccgcaag cggcaaccct 12720

tccaggaggg ctttaggatc acctacgatg atctggaggg tggtaacatt cccgcactgt 12780

tggatgtgga cgcctaccag gcgagcttga aagatgacac cgaacagggc gggggtggcg 12840

caggcggcag caacagcagt ggcagcggcg cggaagagaa ctccaacgcg gcagccgcgg 12900

caatgcagcc ggtggaggac atgaacgatc atgccattcg cggcgacacc tttgccacac 12960

gggctgagga gaagcgcgct gaggccgaag cagcggccga agctgccgcc cccgctgcgc 13020

aacccgaggt cgagaagcct cagaagaaac cggtgatcaa acccctgaca gaggacagca 13080

agaaacgcag ttacaaccta ataagcaatg acagcacctt cacccagtac cgcagctggt 13140

accttgcata caactacggc gaccctcaga ccggaatccg ctcatggacc ctgctttgca 13200

ctcctgacgt aacctgcggc tcggagcagg tctactggtc gttgccagac atgatgcaag 13260

accccgtgac cttccgctcc acgcgccaga tcagcaactt tccggtggtg ggcgccgagc 13320

tgttgcccgt gcactccaag agcttctaca acgaccaggc cgtctactcc caactcatcc 13380

gccagtttac ctctctgacc cacgtgttca atcgctttcc cgagaaccag attttggcgc 13440

gcccgccagc cccccacatc accaccgtca gtgaaaacgt tcctgctctc acagatcacg 13500

ggacgctacc gctgcgcaac agcatcggag gagtccagcg agtgaccatt actgacgcca 13560

gacgccgcac ctgcccctac gtttacaagg ccctgggcat agtctcgccg cgcgtcctat 13620

cgagccgcac tttttgagca agcatgtcca tccttatatc gcccagcaat aacacaggct 13680

ggggcctgcg cttcccaagc aagatgtttg gcggggccaa gaagcgctcc gaccaacacc 13740

cagtgcgcgt gcgcgggcac taccgcgcgc cctggggcgc gcacaaacgc ggccgcactg 13800

ggcgcaccac cgtcgatgac gccatcgacg cggtggtgga ggaggcgcgc aactacacgc 13860

ccacgccgcc accagtgtcc acagtggacg cggccattca gaccgtggtg cgcggagccc 13920

ggcgctatgc taaaatgaag agacggcgga ggcgcgtagc acgtcgccac cgccgccgac 13980

ccggcactgc cgcccaacgc gcggcggcgg ccctgcttaa ccgcgcacgt cgcaccggcc 14040

gacgggcggc catgcgggcc gctcgaaggc tggccgcggg tattgtcact gtgcccccca 14100

ggtccaggcg acgagcggcc gccgcagcag ccgcggccat tagtgctatg actcagggtc 14160

gcaggggcaa cgtgtattgg gtgcgcgact cggttagcgg cctgcgcgtg cccgtgcgca 14220

cccgcccccc gcgcaactag attgcaagaa aaaactactt agactcgtac tgttgtatgt 14280

atccagcggc ggcggcgcgc aacgaagcta tgtccaagcg caaaatcaaa gaagagatgc 14340

tccaggtcat cgcgccggag atctatggcc ccccgaagaa ggaagagcag gattacaagc 14400

cccgaaagct aaagcgggtc aaaaagaaaa agaaagatga tgatgatgaa cttgacgacg 14460

aggtggaact gctgcacgct accgcgccca ggcgacgggt acagtggaaa ggtcgacgcg 14520

taaaacgtgt tttgcgaccc ggcaccaccg tagtctttac gcccggtgag cgctccaccc 14580

gcacctacaa gcgcgtgtat gatgaggtgt acggcgacga ggacctgctt gagcaggcca 14640

acgagcgcct cggggagttt gcctacggaa agcggcataa ggacatgctg gcgttgccgc 14700

tggacgaggg caacccaaca cctagcctaa agcccgtaac actgcagcag gtgctgcccg 14760

cgcttgcacc gtccgaagaa aagcgcggcc taaagcgcga gtctggtgac ttggcaccca 14820

ccgtgcagct gatggtaccc aagcgccagc gactggaaga tgtcttggaa aaaatgaccg 14880

tggaacctgg gctggagccc gaggtccgcg tgcggccaat caagcaggtg gcgccgggac 14940

tgggcgtgca gaccgtggac gttcagatac ccactaccag tagcaccagt attgccaccg 15000

ccacagaggg catggagaca caaacgtccc cggttgcctc agcggtggcg gatgccgcgg 15060

tgcaggcggt cgctgcggcc gcgtccaaga cctctacgga ggtgcaaacg gacccgtgga 15120

tgtttcgcgt ttcagccccc cggcgcccgc gccgttcgag gaagtacggc gccgccagcg 15180

cgctactgcc cgaatatgcc ctacatcctt ccattgcgcc tacccccggc tatcgtggct 15240

acacctaccg ccccagaaga cgagcaacta cccgacgccg aaccaccact ggaacccgcc 15300

gccgccgtcg ccgtcgccag cccgtgctgg ccccgatttc cgtgcgcagg gtggctcgcg 15360

aaggaggcag gaccctggtg ctgccaacag cgcgctacca ccccagcatc gtttaaaagc 15420

cggtctttgt ggttcttgca gatatggccc tcacctgccg cctccgtttc ccggtgccgg 15480

gattccgagg aagaatgcac cgtaggaggg gcatggccgg ccacggcctg acgggcggca 15540

tgcgtcgtgc gcaccaccgg cggcggcgcg cgtcgcaccg tcgcatgcgc ggcggtatcc 15600

tgcccctcct tattccactg atcgccgcgg cgattggcgc cgtgcccgga attgcatccg 15660

tggccttgca ggcgcagaga cactgattaa aaacaagttg catgtggaaa aatcaaaata 15720

aaaagtctgg actctcacgc tcgcttggtc ctgtaactat tttgtagaat ggaagacatc 15780

aactttgcgt ctctggcccc gcgacacggc tcgcgcccgt tcatgggaaa ctggcaagat 15840

atcggcacca gcaatatgag cggtggcgcc ttcagctggg gctcgctgtg gagcggcatt 15900

aaaaatttcg gttccaccgt taagaactat ggcagcaagg cctggaacag cagcacaggc 15960

cagatgctga gggataagtt gaaagagcaa aatttccaac aaaaggtggt agatggcctg 16020

gcctctggca ttagcggggt ggtggacctg gccaaccagg cagtgcaaaa taagattaac 16080

agtaagcttg atccccgccc tcccgtagag gagcctccac cggccgtgga gacagtgtct 16140

ccagaggggc gtggcgaaaa gcgtccgcgc cccgacaggg aagaaactct ggtgacgcaa 16200

atagacgagc ctccctcgta cgaggaggca ctaaagcaag gcctgcccac cacccgtccc 16260

atcgcgccca tggctaccgg agtgctgggc cagcacacac ccgtaacgct ggacctgcct 16320

ccccccgccg acacccagca gaaacctgtg ctgccaggcc cgaccgccgt tgttgtaacc 16380

cgtcctagcc gcgcgtccct gcgccgcgcc gccagcggtc cgcgatcgtt gcggcccgta 16440

gccagtggca actggcaaag cacactgaac agcatcgtgg gtctgggggt gcaatccctg 16500

aagcgccgac gatgcttctg atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg 16560

tcgccgccag aggagctgct gagccgccgc gcgcccgctt tccaagatgg ctaccccttc 16620

gatgatgccg cagtggtctt acatgcacat ctcggggccag gacgcctcgg agtacctgag 16680

ccccgggctg gtgcagtttg cccgcgccac cgagacgtac ttcagcctga ataacaagtt 16740

tagaaacccc acggtggcgc ctacgcacga cgtgaccaca gaccggtccc agcgtttgac 16800

gctgcggttc atccctgtgg accgtgagga tactgcgtac tcgtacaagg cgcggttcac 16860

cctagctgtg ggtgataacc gtgtgctgga catggcttcc acgtactttg acatccgcgg 16920

cgtgctggac aggggcccta cttttaagcc ctactctggc actgcctaca acgccctggc 16980

tcccaagggt gccccaaatc cttgcgaatg ggatgaagct gctactgctc ttgaaataaa 17040

cctagaagaa gaggacgatg acaacgaaga cgaagtagac gagcaagctg agcagcaaaa 17100

aactcacgta tttgggcagg cgccttattc tggtataaat attacaaagg agggtattca 17160

aataggtgtc gaaggtcaaa cacctaaata tgccgataaa acatttcaac ctgaacctca 17220

aataggagaa tctcagtggt acgaaacaga aattaatcat gcagctggga gagtcctaaa 17280

aaagactacc ccaatgaaac catgttacgg ttcatatgca aaacccacaa atgaaaatgg 17340

agggcaaggc attcttgtaa agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca 17400

atttttctca actactgagg cagccgcagg caatggtgat aacttgactc ctaaagtggt 17460

attgtacagt gaagatgtag atatagaaac cccagacact catatttctt acatgcccac 17520

tattaaggaa ggtaactcac gagaactaat gggccaacaa tctatgccca acaggcctaa 17580

ttacattgct tttagggaca attttattgg tctaatgtat tacaacagca cgggtaatat 17640

gggtgttctg gcgggccaag catcgcagtt gaatgctgtt gtagatttgc aagacagaaa 17700

cacagagctt tcataccagc ttttgcttga ttccattggt gatagaacca ggtacttttc 17760

tatgtggaat caggctgttg acagctatga tccagatgtt agaattattg aaaatcatgg 17820

aactgaagat gaacttccaa attactgctt tccactggga ggtgtgatta atacagagac 17880

tcttaccaag gtaaaaccta aaacaggtca ggaaaatgga tgggaaaaag atgctacaga 17940

attttcagat aaaaatgaaa taagagttgg aaataatttt gccatggaaa tcaatctaaa 18000

tgccaacctg tggagaaatt tcctgtactc caacatagcg ctgtatttgc ccgacaagct 18060

aaagtacagt ccttccaacg taaaaatttc tgataaccca aacacctacg actacatgaa 18120

caagcgagtg gtggctcccg ggctagtgga ctgctacatt aaccttggag cacgctggtc 18180

ccttgactat atggacaacg tcaacccatt taaccaccac cgcaatgctg gcctgcgcta 18240

ccgctcaatg ttgctgggca atggtcgcta tgtgcccttc cacatccagg tgcctcagaa 18300

gttctttgcc attaaaaacc tccttctcct gccggggctca tacacctacg agtggaactt 18360

caggaaggat gttaacatgg ttctgcagag ctccctagga aatgacctaa gggttgacgg 18420

agccagcatt aagtttgata gcatttgcct ttacgccacc ttcttcccca tggcccacaa 18480

caccgcctcc acgcttgagg ccatgcttag aaacgacacc aacgaccagt cctttaacga 18540

ctatctctcc gccgccaaca tgctctaccc tatacccgcc aacgctacca acgtgcccat 18600

atccatcccc tcccgcaact gggcggcttt ccgcggctgg gccttcacgc gccttaagac 18660

taaggaaacc ccatcactgg gctcgggcta cgacccttat tacacctact ctggctctat 18720

accctaccta gatggaacct tttacctcaa ccacaccttt aagaaggtgg ccattacctt 18780

tgactcttct gtcagctggc ctggcaatga ccgcctgctt acccccaacg agtttgaaat 18840

taagcgctca gttgacgggg agggttacaa cgttgcccag tgtaacatga ccaaagactg 18900

gttcctggta caaatgctag ctaactataa cattggctac cagggcttct atatcccaga 18960

gagctacaag gaccgcatgt actccttctt tagaaacttc cagcccatga gccgtcaggt 19020

ggtggatgat actaaataca aggactacca acaggtgggc atcctacacc aacacaacaa 19080

ctctggattt gttggctacc ttgcccccac catgcgcgaa ggacaggcct accctgctaa 19140

cttccctat ccgcttatag gcaagaccgc agttgacagc attacccaga aaaagtttct 19200

ttgcgatcgc accctttggc gcatcccatt ctccagtaac tttatgtcca tgggcgcact 19260

cacagacctg ggccaaaacc ttctctacgc caactccgcc cacgcgctag acatgacttt 19320

tgaggtggat cccatggacg agcccaccct tctttatgtt ttgtttgaag tctttgacgt 19380

ggtccgtgtg caccagccgc accgcggcgt catcgaaacc gtgtacctgc gcacgccctt 19440

ctcggccggc aacgccacaa cataaagaag caagcaacat caacaacagc tgccgccatg 19500

ggctccagtg agcaggaact gaaagccatt gtcaaagatc ttggttgtgg gccatatttt 19560

ttgggcacct atgacaagcg ctttccaggc tttgtttctc cacacaagct cgcctgcgcc 19620

atagtcaata cggccggtcg cgagactggg ggcgtacact ggatggcctt tgcctggaac 19680

ccgcactcaa aaacatgcta cctctttgag ccctttggct tttctgacca gcgactcaag 19740

caggtttacc agtttgagta cgagtcactc ctgcgccgta gcgccattgc ttcttccccc 19800

gaccgctgta taacgctgga aaagtccacc caaagcgtac aggggcccaa ctcggccgcc 19860

tgtggactat tctgctgcat gtttctccac gcctttgcca actggcccca aactcccatg 19920

gatcacaacc cccacatgaa ccttattacc ggggtaccca actccatgct caacagtccc 19980

caggtacagc ccaccctgcg tcgcaaccag gaacagctct acagcttcct ggagcgccac 20040

tcgccctact tccgcagcca cagtgcgcag attaggagcg ccacttcttt ttgtcacttg 20100

aaaaacatgt aaaaataatg tactagagac actttcaata aaggcaaatg cttttatttg 20160

tacactctcg ggtgattatt tacccccacc cttgccgtct gcgccgttta aaaatcaaag 20220

gggttctgcc gcgcatcgct atgcgccact ggcagggaca cgttgcgata ctggtgttta 20280

gtgctccact taaactcagg cacaaccatc cgcggcagct cggtgaagtt ttcactccac 20340

aggctgcgca ccatcaccaa cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag 20400

ttggggcctc cgccctgcgc gcgcgagttg cgatacacag ggttgcagca ctggaacact 20460

atcagcgccg ggtggtgcac gctggccagc acgctcttgt cggagatcag atccgcgtcc 20520

aggtcctccg cgttgctcag ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag 20580

ggcgcgtgcc caggctttga gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc 20640

ccggtctggg cgttaggata cagcgcctgc ataaaagcct tgatctgctt aaaagccacc 20700

tgagcctttg cgccttcaga gaagaacatg ccgcaagact tgccggaaaa ctgattggcc 20760

ggacaggccg cgtcgtgcac gcagcacctt gcgtcggtgt tggagatctg caccacattt 20820

cggccccacc ggttcttcac gatcttggcc ttgctagact gctccttcag cgcgcgctgc 20880

ccgttttcgc tcgtcacatc catttcaatc acgtgctcct tatttatcat aatgcttccg 20940

tgtagacact taagctcgcc ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc 21000

gtgggctcgt gatgcttgta ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat 21060

cgccccatca tcgtcacaaa ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc 21120

tcctcgttca gccaggtctt gcatacggcc gccagagctt ccacttggtc aggcagtagt 21180

ttgaagttcg cctttagatc gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc 21240

tccatgccct tctcccacgc agacacgatc ggcacactca gcgggttcat caccgtaatt 21300

tcactttccg cttcgctggg ctcttcctct tcctcttgcg tccgcatacc acgcgccact 21360

gggtcgtctt cattcagccg ccgcactgtg cgcttacctc ctttgccatg cttgattagc 21420

accggtgggt tgctgaaacc caccatttgt agcgccacat cttctctttc ttcctcgctg 21480

tccacgatta cctctggtga tggcgggcgc tcgggcttgg gagaagggcg cttctttttc 21540

ttcttgggcg caatggccaa atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc 21600

ggcaccagcg cgtcttgtga tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc 21660

cgcttttttg ggggcgcccg gggaggcggc ggcgacgggg acggggacga cacgtcctcc 21720

atggttgggg gacgtcgcgc cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc 21780

tcttcccgac tggccatttc cttctcctat aggcagaaaa agatcatgga gtcagtcgag 21840

aagaaggaca gcctaaccgc cccctctgag ttcgccacca ccgcctccac cgatgccgcc 21900

aacgcgccta ccaccttccc cgtcgaggca cccccgcttg aggagggagga agtgattatc 21960

gagcaggacc caggttttgt aagcgaagac gacgaggacc gctcagtacc aacagaggat 22020

aaaaagcaag acccaggacaa cgcagaggca aacgaggaac aagtcgggcg gggggacgaa 22080

aggcatggcg actacctaga tgtgggagac gacgtgctgt tgaagcatct gcagcgccag 22140

tgcgccatta tctgcgacgc gttgcaagag cgcagcgatg tgcccctcgc catagcggat 22200

gtcagccttg cctacgaacg ccacctattc tcaccgcgcg taccccccaa acgccaagaa 22260

aacggcacat gcgagcccaa cccgcgcctc aacttctacc ccgtatttgc cgtgccagag 22320

gtgcttgcca cctatcacat ctttttccaa aactgcaaga tacccctatc ctgccgtgcc 22380

aaccgcagcc gagcggacaa gcagctggcc ttgcggcagg gcgctgtcat acctgatatc 22440

gcctcgctca acgaagtgcc aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg 22500

gcaaacgctc tgcaacagga aaacagcgaa aatgaaagtc actctggagt gttggtggaa 22560

ctcgaggtg acaacgcgcg cctagccgta ctaaaacgca gcatcgaggt cacccacttt 22620

gcctacccgg cacttaacct accccccaag gtcatgagca cagtcatgag tgagctgatc 22680

gtgcgccgtg cgcagcccct ggagagggat gcaaatttgc aagaacaaac agaggagggc 22740

ctacccgcag ttggcgacga gcagctagcg cgctggcttc aaacgcgcga gcctgccgac 22800

ttggagggagc gacgcaaact aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc 22860

atgcagcggt tctttgctga cccggagatg cagcgcaagc tagaggaaac attgcactac 22920

acctttcgac agggctacgt acgccaggcc tgcaagatct ccaacgtgga gctctgcaac 22980

ctggtctcct accttggaat tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc 23040

acgctcaagg gcgaggcgcg ccgcgactac gtccgcgact gcgtttactt atttctatgc 23100

tacacctggc agacggccat gggcgtttgg cagcagtgct tggagggagtg caacctcaag 23160

gagctgcaga aactgctaaa gcaaaacttg aaggacctat ggacggcctt caacgagcgc 23220

tccgtggccg cgcacctggc ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa 23280

cagggtctgc cagacttcac cagtcaaagc atgttgcaga actttaggaa ctttatccta 23340

gagcgctcag gaatcttgcc cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt 23400

aagtaccgcg aatgccctcc gccgctttgg ggccactgct accttctgca gctagccaac 23460

taccttgcct accactctga cataatggaa gacgtgagcg gtgacggtct actggagtgt 23520

cactgtcgct gcaacctatg caccccgcac cgctccctgg tttgcaattc gcagctgctt 23580

aacgaaagtc aaattatcgg tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc 23640

gcggctccgg ggttgaaact cactccgggg ctgtggacgt cggcttacct tcgcaaattt 23700

gtacctgagg actaccacgc ccacgagatt aggttctacg aagaccaatc ccgcccgcct 23760

aatgcggagc ttaccgcctg cgtcattacc cagggccaca ttcttggcca attgcaagcc 23820

atcaacaaag cccgccaaga gtttctgcta cgaaagggac ggggggttta cttggacccc 23880

cagtccggcg aggagctcaa cccaatcccc ccgccgccgc agccctatca gcagcagccg 23940

cgggcccttg cttcccagga tggcacccaa aaagaagctg cagctgccgc cgccacccac 24000

ggacgaggag gaatactggg acagtcaggc agaggaggtt ttggacgagg aggaggagga 24060

catgatggaa gactgggaga gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga 24120

cgaaacaccg tcaccctcgg tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg 24180

ttccagcatg gctacaacct ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc 24240

caaccgtaga tgggacacca ctggaaccag ggccggtaag tccaagcagc cgccgccgtt 24300

agcccaagag caacaacagc gccaaggcta ccgctcatgg cgcgggcaca agaacgccat 24360

agttgcttgc ttgcaagact gtggggggcaa catctccttc gcccgccgct ttcttctcta 24420

ccatcacggc gtggccttcc cccgtaacat cctgcattac taccgtcatc tctacagccc 24480

atactgcacc ggcggcagcg gcagcaacag cagcggccac acagaagcaa aggcgaccgg 24540

atagcaagac tctgacaaag cccaagaaat ccacagcggc ggcagcagca ggaggaggag 24600

cgctgcgtct ggcgcccaac gaacccgtat cgacccgcga gcttagaaac aggatttttc 24660

ccactctgta tgctatattt caacagagca ggggccaaga acaagagctg aaaataaaaa 24720

acaggtctct gcgatccctc acccgcagct gcctgtatca caaaagcgaa gatcagcttc 24780

ggcgcacgct ggaagacgcg gaggctctct tcagtaaata ctgcgcgctg actcttaagg 24840

actagtttcg cgccctttct caaatttaag cgcgaaaact acgtcatctc cagcggccac 24900

acccggcgcc agcacctgtt gtcagcgcca ttatgagcaa ggaaattccc acgccctaca 24960

tgtggagtta ccagccacaa atgggacttg cggctggagc tgcccaagac tactcaaccc 25020

gaataaacta catgagcgcg ggaccccaca tgatatcccg ggtcaacgga atacgcgccc 25080

accgaaaccg aattctcctg gaacaggcgg ctattaccac cacacctcgt aataacctta 25140

atccccgtag ttggcccgct gccctggtgt accaggaaag tcccgctccc accactgtgg 25200

tacttcccag agacgcccag gccgaagttc agatgactaa ctcaggggcg cagcttgcgg 25260

gcggctttcg tcacagggtg cggtcgcccg ggcagggtat aactcacctg acaatcagag 25320

ggcgaggtat tcagctcaac gacgagtcgg tgagctcctc gcttggtctc cgtccggacg 25380

ggacatttca gatcggcggc gccggccgct cttcattcac gcctcgtcag gcaatcctaa 25440

ctctgcagac ctcgtcctct gagccgcgct ctggaggcat tggaactctg caatttattg 25500

aggagtttgt gccatcggtc tactttaacc ccttctcggg acctcccggc cactatccgg 25560

atcaatttat tcctaacttt gacgcggtaa aggactcggc ggacggctac gactgaatgt 25620

taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc cgccacaagt 25680

gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat catatcgagg 25740

gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc ctgattcggg 25800

agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt ctcactgtga 25860

tttgcaactg tcctaaccct ggattacatc aagatcctct agttaatgtc aggtcgccta 25920

agtcgattaa ctagagtacc cggggatctt attcccttta actaataaaa aaaaataata 25980

aagcatcact tacttaaaat cagttagcaa atttctgtcc agtttattca gcagcacctc 26040

cttgccctcc tcccagctct ggtattgcag cttcctcctg gctgcaaact ttctccacaa 26100

tctaaatgga atgtcagttt cctcctgttc ctgtccatcc gcacccacta tcttcatgtt 26160

gttgcagatg aagcgcgcaa gaccgtctga agataccttc aaccccgtgt atccatatga 26220

cacggaaacc ggtcctccaa ctgtgccttt tcttactcct ccctttgtat cccccaatgg 26280

gtttcaagag agtccccctg gggtactctc tttgcgccta tccgaacctc tagttacctc 26340

caatggcatg cttgcgctca aaatgggcaa cggcctctct ctggacgagg ccggcaacct 26400

tacctcccaa aatgtaacca ctgtgagccc acctctcaaa aaaaccaagt caaacataaa 26460

cctggaaata tctgcacccc tcacagttac ctcagaagcc ctaactgtgg ctgccgccgc 26520

acctctaatg gtcgcgggca acacactcac catgcaatca caggccccgc taaccgtgca 26580

cgactccaaa cttagcattg cacccaagg acccctcaca gtgtcagaag gaaagctagc 26640

cctgcaaaca tcaggccccc tcaccaccac cgatagcagt acccttacta tcactgcctc 26700

accccctcta actactgcca ctggtagctt gggcattgac ttgaaagagc ccatttatac 26760

acaaaatgga aaactaggac taaagtacgg ggctcctttg catgtaacag acgacctaaa 26820

cactttgacc gtagcaactg gtccaggtgt gactattaat aatacttcct tgcaaactaa 26880

agttactgga gccttgggtt ttgattcaca aggcaatatg caacttaatg tagcaggagg 26940

actaaggatt gattctcaaa agacgcct tatacttgat gttagttatc cgtttgatgc 27000

tcaaaaccaa ctaaatctaa gactaggaca gggccctctt tttataaact cagcccacaa 27060

cttggatatt aactacaaca aaggccttta cttgtttaca gcttcaaaca attccaaaaa 27120

gcttgaggtt aacctaagca ctgccaaggg gttgatgttt gacgctacag ccatagccat 27180

taatgcagga gatgggcttg aatttggttc acctaatgca ccaaacacaa atcccctcaa 27240

aacaaaaatt ggccatggcc tagaatttga ttcaaacaag gctatggttc ctaaactagg 27300

aactggcctt agttttgaca gcacaggtgc cattacagta ggaaacaaaa ataatgataa 27360

gctaactttg tggaccggaa taaaccctcc acctaactgt caaattgtgg aaaacactaa 27420

tacaaatgat ggcaaactta ctttagtatt agtaaaaaat ggagggcttg ttaatggcta 27480

cgtgtctcta gttggtgtat cagacactgt gaaccaaatg ttcacacaaa agacagcaaa 27540

catccaatta agattatatt ttgactcttc tggaaatcta ttaactgagg aatcagactt 27600

aaaaattcca cttaaaaata aatcttctac agcgaccagt gaaactgtag ccagcagcaa 27660

agcctttatg ccaagtacta cagcttatcc cttcaacacc actactaggg atagtgaaaa 27720

ctacattcat ggaatatgtt actacatgac tagttatgat agaagtctat ttcccttgaa 27780

catttctata atgctaaaca gccgtatgat ttcttccaat gttgcctatg ccatacaatt 27840

tgaatggaat ctaaatgcaa gtgaatctcc agaaagcaac atagctacgc tgaccacatc 27900

cccctttttc ttttcttaca ttacagaaga cgacaactaa agaatcgttt gtgttatgtt 27960

tcaacgtgtt tatttttcaa ttgcagaaaa tttcaagtca tttttcattc agtagtatag 28020

ccccaccacc acatagctta tacagatcac cgtaccttaa tcaaactcac agaaccctag 28080

tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg 28140

ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg 28200

tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta 28260

agttcatgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa 28320

cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga 28380

tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc 28440

aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 28500

gccttgtcct ccggggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 28560

agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 28620

tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 28680

gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 28740

cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 28800

agctggccaa aacctgcccg ccggctatac actgcaggga acggggactg gaacaatgac 28860

agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg 28920

cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 28980

ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 29040

ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 29100

cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 29160

gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg 29220

acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 29280

cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 29340

tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 29400

acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 29460

cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 29520

atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 29580

aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 29640

aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 29700

ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 29760

caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 29820

agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 29880

cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 29940

cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc 30000

ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 30060

ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 30120

ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca 30180

tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 30240

aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 30300

tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 30360

tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 30420

cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 30480

tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 30540

acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac 30600

ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 30660

cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 30720

aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 30780

agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 30840

aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 30900

tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 30960

acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg 31020

ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 31080

tattgatgat g 31091

<210> 22

<211> 37678

<212> DNA

<213> Artificial sequence

<220>

<223> plasmid vector #1

<400> 22

ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag 180

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa 780

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt 1020

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc 1200

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320

ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tactgggcta 1440

tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500

ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560

cgccctctgg taaggttggg aagccctgca aagtaaactg gatggctttc ttgccgccaa 1620

ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860

aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc 2040

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg 2460

acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520

gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640

aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt 2880

aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940

atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000

tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060

atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120

tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180

aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240

gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 3300

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta 3600

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccatg 3720

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780

actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca 3840

gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt cgacgagctc 3900

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa 3960

gacaccggga ccgatccagc ctccgatttg ccaccatgtt tgtgttcctg gtgctgctgc 4020

cactggtgtc cagccagtgt gtgaacctga ccaccaggac ccaacttcct cctgcctaca 4080

ccaactcctt caccagggga gtctactacc ctgacaaggt gttcaggtcc tctgtgctgc 4140

acagcaccca ggacctgttc ctgccattct tcagcaatgt gacctggttc catgccatcc 4200

atgtgtctgg caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg 4260

gagtctactt tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca 4320

ccctggacag caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta 4380

aggtgtgtga gttccagttc tgtaatgacc cattcctggg agtctactac cacaagaaca 4440

acaagtcctg gatggagtct gagttcaggg tctactcctc tgccaacaac tgtacctttg 4500

aatatgtgag ccaaccattc ctgatggact tggagggcaa gcagggcaac ttcaagaacc 4560

tgagggagtt tgtgttcaag aacattgatg gctacttcaa gatttacagc aaacacacac 4620

caatcaacct ggtgagggac ctgccacagg gcttctctgc cttggaacca ctggtggacc 4680

tgccaattgg catcaacatc accaggttcc agaccctgct ggctctgcac aggtcctacc 4740

tgacacctgg agactcctcc tctggctgga cagcaggagc agcagcctac tatgtgggct 4800

acctccaacc aaggaccttc ctgctgaaat acaatgagaa tggcaccatc acagatgctg 4860

tggactgtgc cctggaccca ctgtctgaga ccaagtgtac cctgaaatcc ttcacagtgg 4920

agaagggcat ctaccagacc agcaacttca gggtccaacc aacagagagc attgtgaggt 4980

ttccaaacat caccaacctg tgtccattg gagaggtgtt caatgccacc aggtttgcct 5040

ctgtctatgc ctggaacagg aagaggatta gcaactgtgt ggctgactac tctgtgctct 5100

acaactctgc ctccttcagc accttcaagt gttatggagt gagcccaacc aaactgaatg 5160

acctgtgttt caccaatgtc tatgctgact cctttgtgat taggggagat gaggtgagac 5220

agattgcccc tggacaaaca ggcaagattg ctgactacaa ctacaaactg cctgatgact 5280

tcacaggctg tgtgattgcc tggaacagca acaacctgga cagcaaggtg ggaggcaact 5340

acaactacct ctacagactg ttcaggaaga gcaacctgaa accatttgag agggacatca 5400

gcacagagat ttaccaggct ggcagcacac catgtaatgg agtggagggc ttcaactgtt 5460

actttccact ccaatcctat ggcttccaac caaccaatgg agtgggctac caaccataca 5520

gggtggtggt gctgtccttt gaactgctcc atgcccctgc cacagtgtgt ggaccaaaga 5580

agagcaccaa cctggtgaag aacaagtgtg tgaacttcaa cttcaatgga ctgacaggca 5640

caggagtgct gacagagagc aacaagaagt tcctgccatt ccaacagttt ggcagggaca 5700

ttgctgacac cacagatgct gtgagggacc cacagacctt ggagattctg gacatcacac 5760

catgttcctt tggagagtg tctgtgatta cacctggcac caacaccagc aaccaggtgg 5820

ctgtgctcta ccaggatgtg aactgtactg aggtgcctgt ggctatccat gctgaccaac 5880

ttacaccaac ctggagggtc tacagcacag gcagcaatgt gttccagacc agggctggct 5940

gtctgattgg agcagagcat gtgaacaact cctatgagtg tgacatccca attggagcag 6000

gcatctgtgc ctcctaccag acccagacca acagcccaag gagggcaagg tctgtggcaa 6060

gccagagcat cattgcctac acaatgagtc tgggagcaga gaactctgtg gcttacagca 6120

acaacagcat tgccatccca accaacttca ccatctctgt gaccacagag attctgcctg 6180

tgagtatgac caagacctct gtggactgta caatgtatat ctgtggagac agcacagagt 6240

gtagcaacct gctgctccaa tatggctcct tctgtaccca acttaacagg gctctgacag 6300

gcattgctgt ggaacaggac aagaacaccc aggaggtgtt tgcccaggtg aagcagattt 6360

acaagacacc tccaatcaag gactttggag gcttcaactt cagccagatt ctgcctgacc 6420

caagcaagcc aagcaagagg tccttcattg aggacctgct gttcaacaag gtgaccctgg 6480

ctgatgctgg cttcatcaag caatatggag actgtctggg agacattgct gccagggacc 6540

tgatttgtgc ccagaagttc aatggactga cagtgctgcc tccactgctg acagatgaga 6600

tgattgccca atacacctct gccctgctgg ctggcaccat cacctctggc tggacctttg 6660

gagcaggagc agccctccaa atcccatttg ctatgcagat ggcttacagg ttcaatggca 6720

ttggagtgac ccagaatgtg ctctatgaga accagaaact gattgccaac cagttcaact 6780

ctgccattgg caagattcag gactccctgt ccagcacagc ctctgccctg ggcaaactcc 6840

aagatgtggt gaaccagaat gcccaggctc tgaacaccct ggtgaagcaa ctttccagca 6900

actttggagc catctcctct gtgctgaatg acatcctgag cagactggac aaggtggagg 6960

ctgaggtcca gattgacaga ctgattacag gcagactcca atccctccaa acctatgtga 7020

cccaacaact tatcagggct gctgagatta gggcatctgc caacctggct gccaccaaga 7080

tgagtgagtg tgtgctggga caaagcaaga gggtggactt ctgtggcaag ggctaccacc 7140

tgatgagttt tccacagtct gcccctcatg gagtggtgtt cctgcatgtg acctatgtgc 7200

ctgcccagga gaagaacttc accacagccc ctgccatctg ccatgatggc aaggctcact 7260

ttccaaggga gggagtgttt gtgagcaatg gcacccactg gtttgtgacc cagaggaact 7320

tctatgaacc acagattatc accacagaca acacctttgt gtctggcaac tgtgatgtgg 7380

tgattggcat tgtgaacaac acagtctatg acccactcca acctgaactg gactccttca 7440

aggaggaact ggacaaatac ttcaagaacc acaccagccc tgatgtggac ctgggagaca 7500

tctctggcat caatgcctct gtggtgaaca tccagaagga gattgacaga ctgaatgagg 7560

tggctaagaa cctgaatgag tccctgattg acctccaaga actgggcaaa tatgaacaat 7620

acatcaagtg gccatgaaaa ttgatcataa tcagccatac cacatttgta gaggttttac 7680

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 7740

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 7800

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 7860

atgtatctta acgcggatct gggcgtggtt aagggtggga aagaatatat aaggtggggg 7920

tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca ccaactcgtt 7980

tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg ccggggtgcg 8040

tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa actctactac 8100

cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg ccgccgcttc 8160

agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga gcccgcttgc 8220

aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc ttttggcaca 8280

attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg atctgcgcca 8340

gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa 8400

accagactct gtttggattt ggatcaagca agtgtcttgc tgtctttatt taggggtttt 8460

gcgcgcgcgg taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc 8520

caggacgtgg taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg 8580

gtggaggtag caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc 8640

gtagcaggag cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag 8700

gggcaggccc ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg 8760

ggatatgaga tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct 8820

ccggggattc atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt 8880

gtcatgtagc ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag 8940

attttccatg cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa 9000

gatatttctg ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat 9060

ttttacaaag cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg 9120

ggcgtagtta ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat 9180

gtctacctgc ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga 9240

aagcaggttc ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat 9300

taccggctgc aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc 9360

cacttcgtta agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg 9420

ctcgccgccc agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc 9480

gtccgccgta ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc 9540

ggtcacctgc tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg 9600

ctttcgctgt acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac 9660

gggcgcaggg tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc 9720

gcgctggcca gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg 9780

ccctgcgcgt cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg 9840

tggcccttgg cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt 9900

ttgagggcgt agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg 9960

caggccccgc agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca 10020

aaaaccaggt ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg 10080

tgtccacgct cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg 10140

tcctcgagcg gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag 10200

gctcgcgtcc aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact 10260

aggggggtcca ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag 10320

gtgattggtt tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag 10380

ggggtggggg cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt 10440

tggggtgagt actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc 10500

aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca 10560

tccatctggt cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag 10620

agggcgttgg acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg 10680

cgctccttgg ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga 10740

aagacggtgg tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg 10800

acaaggtcaa cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg 10860

ccgcccttgc gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct 10920

gcgtccacgg taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct 10980

tgcaagtcta gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt 11040

gggggacccc atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa 11100

acgtagaggg gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg 11160

ctggcgcgca cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg 11220

ctacgggcgg gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat 11280

gatatggttg gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc 11340

acgaaggagg cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct 11400

agggcgcagt agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc 11460

cacagctcgc ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac 11520

ccgtcggcct ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg 11580

cagcatccct tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg 11640

gtgagcgcaa aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg 11700

tcgcatccgc cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc 11760

agggcgaagg tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg 11820

atgcggaagg gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc 11880

tcgtcaaagc cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc 11940

ttgatggaag gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg 12000

tgctctgaaa gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg 12060

tcacgggcca ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc 12120

attttttctg gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca 12180

aggttcgcgg ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg 12240

accagcatga agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca 12300

tcgtaggtga caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc 12360

tcccgccacc aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg 12420

gccgaacact cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc 12480

tgtacatcct gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg 12540

agcccctcgc ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg 12600

tctggctgct cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc 12660

cagatgtccg cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc 12720

atggtctgga gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat 12780

agacgggtca gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg 12840

gcggcgtcga tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc 12900

gggcggtggg ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag 12960

cccccggagg tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc 13020

cgcgcgcggg caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc 13080

ggttgatctc ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgaacc 13140

tgaaagagag ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct 13200

cctgcacgtc tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt 13260

cctcctggag atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc 13320

gggccatgag ctgcgagaag gcgttgaggc ctccctcgtt cgacgcgg ctgtagacca 13380

cgcccccttc ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc 13440

gggcgaagac ggcgtagttt cgcaggcgct gaaagaggta gttgaggtg gtggcggtgt 13500

gttctgccac gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca 13560

aggcctcaag gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt 13620

tgcgcgccga cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc 13680

gcacctcgcg ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa 13740

gggcctcccc ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac 13800

ggcgcaccgg gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg 13860

tctcggtgac ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt 13920

cccggttatg ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc 13980

tcaacaattg ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg 14040

gatcggaaaa cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca 14100

ccgtggcggg cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga 14160

tgtaattaaa gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg 14220

gtccggcctg ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc 14280

gcaggtcttt gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct 14340

cttgtcctgc atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc 14400

gccctcttcc tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt 14460

cggcgacaac gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt 14520

catccatgtc cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca 14580

taacggacca gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg 14640

agtaagccct cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca 14700

ccaaaaagtg cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg 14760

gggcgagatc ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga 14820

tgccggcggc ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca 14880

gcggcaaaaa gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga 14940

cgctctagcg tgcaaaagga gagcctgtaa gcgggcactc ttccgtggtc tggtggataa 15000

attcgcaagg gtatcatggc ggacgaccgg ggttcgagcc ccgtatccgg ccgtccgccg 15060

tgatccatgc ggttaccgcc cgcgtgtcga acccaggtgt gcgacgtcag acaacggggg 15120

agtgctcctt ttggcttcct tccaggcgcg gcggctgctg cgctagcttt tttggccact 15180

ggccgcgcgc agcgtaagcg gttaggctgg aaagcgaaag cattaagtgg ctcgctccct 15240

gtagccggag ggttattttc caagggttga gtcgcgggac ccccggttcg agtctcggac 15300

cggccggact gcggcgaacg ggggtttgcc tccccgtcat gcaagacccc gcttgcaaat 15360

tcctccggaa acagggacga gccccttttt tgcttttccc agatgcatcc ggtgctgcgg 15420

cagatgcgcc cccctcctca gcagcggcaa gagcaagagc agcggcagac atgcagggca 15480

ccctcccctc ctcctaccgc gtcaggaggg gcgacatccg cggttgacgc ggcagcagat 15540

ggtgattacg aacccccgcg gcgccgggcc cggcactacc tggacttgga ggagggcgag 15600

ggcctggcgc ggctaggagc gccctctcct gagcggcacc caagggtgca gctgaagcgt 15660

gatacgcgtg aggcgtacgt gccgcggcag aacctgtttc gcgaccgcga gggagaggag 15720

cccgaggaga tgcgggatcg aaagttccac gcagggcgcg agctgcggca tggcctgaat 15780

cgcgagcggt tgctgcgcga ggaggacttt gagcccgacg cgcgaaccgg gattagtccc 15840

gcgcgcgcac acgtggcggc cgccgacctg gtaaccgcat acgagcagac ggtgaaccag 15900

gagattaact ttcaaaaaag ctttaacaac cacgtgcgta cgcttgtggc gcgcgaggag 15960

gtggctatag gactgatgca tctgtgggac tttgtaagcg cgctggagca aaacccaaat 16020

agcaagccgc tcatggcgca gctgttcctt atagtgcagc acagcaggga caacgaggca 16080

ttcagggatg cgctgctaaa catagtagag cccgagggcc gctggctgct cgatttgata 16140

aacatcctgc agagcatagt ggtgcaggag cgcagcttga gcctggctga caaggtggcc 16200

gccatcaact attccatgct tagcctgggc aagttttacg cccgcaagat ataccatacc 16260

ccttacgttc ccatagacaa ggaggtaaag atcgaggggt tctacatgcg catggcgctg 16320

aaggtgctta ccttgagcga cgacctgggc gtttatcgca acgagcgcat ccacaaggcc 16380

gtgagcgtga gccggcggcg cgagctcagc gaccgcgagc tgatgcacag cctgcaaagg 16440

gccctggctg gcacggggcag cggcgataga gaggccgagt cctactttga cgcgggcgct 16500

gacctgcgct gggccccaag ccgacgcgcc ctggaggcag ctggggccgg acctgggctg 16560

gcggtggcac ccgcgcgcgc tggcaacgtc ggcggcgtgg aggaatatga cgaggacgat 16620

gagtacgagc cagaggacgg cgagtactaa gcggtgatgt ttctgatcag atgatgcaag 16680

acgcaacgga cccggcggtg cgggcggcgc tgcagagcca gccgtccggc cttaactcca 16740

cggacgactg gcgccaggtc atggaccgca tcatgtcgct gactgcgcgc aatcctgacg 16800

cgttccggca gcagccgcag gccaaccggc tctccgcaat tctggaagcg gtggtcccgg 16860

cgcgcgcaaa ccccacgcac gagaaggtgc tggcgatcgt aaacgcgctg gccgaaaaca 16920

gggccatccg gcccgacgag gccggcctgg tctacgacgc gctgcttcag cgcgtggctc 16980

gttacaacag cggcaacgtg cagaccaacc tggaccggct ggtgggggat gtgcgcgagg 17040

ccgtggcgca gcgtgagcgc gcgcagcagc agggcaacct gggctccatg gttgcactaa 17100

acgccttcct gagtacacag cccgccaacg tgccgcgggg acaggaggac tacaccaact 17160

ttgtgagcgc actgcggcta atggtgactg agacaccgca aagtgaggtg taccagtctg 17220

ggccagacta ttttttccag accagtagac aaggcctgca gaccgtaaac ctgagccagg 17280

ctttcaaaaa cttgcagggg ctgtgggggg tgcgggctcc cacaggcgac cgcgcgaccg 17340

tgtctagctt gctgacgccc aactcgcgcc tgttgctgct gctaatagcg cccttcacgg 17400

acagtggcag cgtgtcccgg gacacatacc taggtcactt gctgacactg taccgcgagg 17460

ccataggtca ggcgcatgtg gacgagcata ctttccagga gattacaagt gtcagccgcg 17520

cgctggggca ggaggaacacg ggcagcctgg aggcaaccct aaactacctg ctgaccaacc 17580

ggcggcagaa gatcccctcg ttgcacagtt taaacagcga ggaggagcgc attttgcgct 17640

acgtgcagca gagcgtgagc cttaacctga tgcgcgacgg ggtaacgccc agcgtggcgc 17700

tggacatgac cgcgcgcaac atggaaccgg gcatgtatgc ctcaaaccgg ccgtttatca 17760

accgcctaat ggactacttg catcgcgcgg ccgccgtgaa ccccgagtat ttcaccaatg 17820

ccatcttgaa cccgcactgg ctaccgcccc ctggtttcta caccggggga ttcgaggtgc 17880

ccgagggtaa cgatggattc ctctgggacg acatagacga cagcgtgttt tccccgcaac 17940

cgcagaccct gctagagttg caacagcgcg agcaggcaga ggcggcgctg cgaaaggaaa 18000

gcttccgcag gccaagcagc ttgtccgatc taggcgctgc ggccccgcgg tcagatgcta 18060

gtagcccatt tccaagcttg atagggtctc ttaccagcac tcgcaccacc cgcccgcgcc 18120

tgctgggcga ggagagtac ctaaacaact cgctgctgca gccgcagcgc gaaaaaaacc 18180

tgcctccggc atttcccaac aacgggatag agagcctagt ggacaagatg agtagatgga 18240

agacgtacgc gcaggagcac agggacgtgc caggcccgcg cccgcccacc cgtcgtcaaa 18300

ggcacgaccg tcagcggggt ctggtgtggg aggacgatga ctcggcagac gacagcagcg 18360

tcctggattt gggagggagt ggcaacccgt ttgcgcacct tcgccccagg ctggggagaa 18420

tgttttaaaa aaaaaaaagc atgatgcaaa ataaaaaact caccaaggcc atggcaccga 18480

gcgttggttt tcttgtattc cccttagtat gcggcgcgcg gcgatgtatg aggaaggtcc 18540

tcctccctcc tacgagagtg tggtgagcgc ggcgccagtg gcggcggcgc tgggttctcc 18600

cttcgatgct cccctggacc cgccgtttgt gcctccgcgg tacctgcggc ctaccggggg 18660

gagaaacagc atccgttact ctgagttggc acccctattc gacaccaccc gtgtgtacct 18720

ggtggacaac aagtcaacgg atgtggcatc cctgaactac cagaacgacc acagcaactt 18780

tctgaccacg gtcattcaaa acaatgacta cagcccgggg gaggcaagca cacagaccat 18840

caatcttgac gaccggtcgc actggggcgg cgacctgaaa accatcctgc ataccaacat 18900

gccaaatgtg aacgagttca tgtttaccaa taagtttaag gcgcgggtga tggtgtcgcg 18960

cttgcctact aaggacaatc aggtggagct gaaatacgag tgggtggagt tcacgctgcc 19020

cgagggcaac tactccgaga ccatgaccat agaccttatg aacaacgcga tcgtggagca 19080

ctacttgaaa gtgggcagac agaacggggt tctggaaagc gacatcgggg taaagtttga 19140

cacccgcaac ttcagactgg ggtttgaccc cgtcactggt cttgtcatgc ctggggtata 19200

tacaaacgaa gccttccatc cagacatcat tttgctgcca ggatgcgggg tggacttcac 19260

ccacagccgc ctgagcaact tgttgggcat ccgcaagcgg caacccttcc aggagggctt 19320

taggatcacc tacgatgatc tggagggtgg taacattccc gcactgttgg atgtggacgc 19380

ctaccaggcg agcttgaaag atgacaccga acagggcggg ggtggcgcag gcggcagcaa 19440

cagcagtggc agcggcgcgg aagagaactc caacgcggca gccgcggcaa tgcagccggt 19500

ggaggacatg aacgatcatg ccattcgcgg cgacaccttt gccacacggg ctgaggagaa 19560

gcgcgctgag gccgaagcag cggccgaagc tgccgccccc gctgcgcaac ccgaggtcga 19620

gaagcctcag aagaaaccgg tgatcaaacc cctgacagag gacagcaaga aacgcagtta 19680

caacctaata agcaatgaca gcaccttcac ccagtaccgc agctggtacc ttgcatacaa 19740

ctacggcgac cctcagaccg gaatccgctc atggaccctg ctttgcactc ctgacgtaac 19800

ctgcggctcg gagcaggtct actggtcgtt gccagacatg atgcaagacc ccgtgacctt 19860

ccgctccacg cgccagatca gcaactttcc ggtggtgggc gccgagctgt tgcccgtgca 19920

ctccaagagc ttctacaacg accaggccgt ctactcccaa ctcatccgcc agtttacctc 19980

tctgacccac gtgttcaatc gctttcccga gaaccagatt ttggcgcgcc cgccagcccc 20040

caccatcacc accgtcagtg aaaacgttcc tgctctcaca gatcacggga cgctaccgct 20100

gcgcaacagc atcggaggag tccagcgagt gaccattact gacgccagac gccgcacctg 20160

cccctacgtt tacaaggccc tgggcatagt ctcgccgcgc gtcctatcga gccgcacttt 20220

ttgagcaagc atgtccatcc ttatatcgcc cagcaataac acaggctggg gcctgcgctt 20280

cccaagcaag atgtttggcg gggccaagaa gcgctccgac caacacccag tgcgcgtgcg 20340

cgggcactac cgcgcgccct ggggcgcgca caaacgcggc cgcactgggc gcaccaccgt 20400

cgatgacgcc atcgacgcgg tggtggagga ggcgcgcaac tacacgccca cgccgccacc 20460

agtgtccaca gtggacgcgg ccattcagac cgtggtgcgc ggagcccggc gctatgctaa 20520

aatgaagaga cggcggaggc gcgtagcacg tcgccaccgc cgccgacccg gcactgccgc 20580

ccaacgcgcg gcggcggccc tgcttaaccg cgcacgtcgc accggccgac gggcggccat 20640

gcgggccgct cgaaggctgg ccgcgggtat tgtcactgtg ccccccaggt ccaggcgacg 20700

agcggccgcc gcagcagccg cggccattag tgctatgact cagggtcgca ggggcaacgt 20760

gtattgggtg cgcgactcgg ttagcggcct gcgcgtgccc gtgcgcaccc gccccccgcg 20820

caactagatt gcaagaaaaa actacttaga ctcgtactgt tgtatgtatc cagcggcggc 20880

ggcgcgcaac gaagctatgt ccaagcgcaa aatcaaagaa gagatgctcc aggtcatcgc 20940

gccggagatc tatggccccc cgaagaagga agagcaggat tacaagcccc gaaagctaaa 21000

gcgggtcaaa aagaaaaaga aagatgatga tgatgaactt gacgacgagg tggaactgct 21060

gcacgctacc gcgcccaggc gacgggtaca gtggaaaggt cgacgcgtaa aacgtgtttt 21120

gcgacccggc accaccgtag tctttacgcc cggtgagcgc tccacccgca cctacaagcg 21180

cgtgtatgat gaggtgtacg gcgacgagga cctgcttgag caggccaacg agcgcctcgg 21240

ggagtttgcc tacggaaagc ggcataagga catgctggcg ttgccgctgg acgagggcaa 21300

cccaacacct agcctaaagc ccgtaacact gcagcaggtg ctgcccgcgc ttgcaccgtc 21360

cgaagaaaag cgcggcctaa agcgcgagtc tggtgacttg gcacccaccg tgcagctgat 21420

ggtacccaag cgccagcgac tggaagatgt cttggaaaaa atgaccgtgg aacctgggct 21480

ggagcccgag gtccgcgtgc ggccaatcaa gcaggtggcg ccgggactgg gcgtgcagac 21540

cgtggacgtt cagataccca ctaccagtag caccagtatt gccaccgcca cagaggcat 21600

ggagacacaa acgtccccgg ttgcctcagc ggtggcggat gccgcggtgc aggcggtcgc 21660

tgcggccgcg tccaagacct ctacggaggt gcaaacggac ccgtggatgt ttcgcgtttc 21720

agccccccgg cgcccgcgcc gttcgaggaa gtacggcgcc gccagcgcgc tactgcccga 21780

atatgcccta catccttcca ttgcgcctac ccccggctat cgtggctaca cctaccgccc 21840

cagaagacga gcaactaccc gacgccgaac caccactgga acccgccgcc gccgtcgccg 21900

tcgccagccc gtgctggccc cgatttccgt gcgcagggtg gctcgcgaag gaggcaggac 21960

cctggtgctg ccaacagcgc gctaccaccc cagcatcgtt taaaagccgg tctttgtggt 22020

tcttgcagat atggccctca cctgccgcct ccgtttcccg gtgccgggat tccgaggaag 22080

aatgcaccgt aggaggggca tggccggcca cggcctgacg ggcggcatgc gtcgtgcgca 22140

ccaccggcgg cggcgcgcgt cgcaccgtcg catgcgcggc ggtatcctgc ccctccttat 22200

tccactgatc gccgcggcga ttggcgccgt gcccggaatt gcatccgtgg ccttgcaggc 22260

gcagagacac tgattaaaaa caagttgcat gtggaaaaat caaaataaaa agtctggact 22320

ctcacgctcg cttggtcctg taactatttt gtagaatgga agacatcaac tttgcgtctc 22380

tggccccgcg acacggctcg cgcccgttca tgggaaactg gcaagatatc ggcaccagca 22440

atatgagcgg tggcgccttc agctggggct cgctgtggag cggcattaaa aatttcggtt 22500

ccaccgttaa gaactatggc agcaaggcct ggaacagcag cacaggccag atgctgaggg 22560

ataagttgaa agagcaaaat ttccaacaaa aggtggtaga tggcctggcc tctggcatta 22620

gcggggtggt ggacctggcc aaccaggcag tgcaaaataa gattaacagt aagcttgatc 22680

cccgccctcc cgtagaggag cctccaccgg ccgtggagac agtgtctcca gagggcgtg 22740

gcgaaaagcg tccgcgcccc gacagggaag aaactctggt gacgcaaata gacgagcctc 22800

cctcgtacga ggaggcacta aagcaaggcc tgcccaccac ccgtcccatc gcgcccatgg 22860

ctaccggagt gctgggccag cacacacccg taacgctgga cctgcctccc cccgccgaca 22920

cccagcagaa acctgtgctg ccaggcccga ccgccgttgt tgtaacccgt cctagccgcg 22980

cgtccctgcg ccgcgccgcc agcggtccgc gatcgttgcg gcccgtagcc agtggcaact 23040

ggcaaagcac actgaacagc atcgtgggtc tggggggtgca atccctgaag cgccgacgat 23100

gcttctgata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 23160

agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 23220

tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 23280

cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 23340

gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 23400

cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 23460

gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 23520

ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 23580

ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 23640

gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 23700

gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 23760

ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 23820

cagtggtacg aaacagaaat taatcatgca gctgggagag tcctaaaaaa gactacccca 23880

atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 23940

cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 24000

actgaggcag ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 24060

gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 24120

aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 24180

agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 24240

ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 24300

taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 24360

gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 24420

cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 24480

aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 24540

aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 24600

agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 24660

tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 24720

gctcccgggc tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 24780

gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 24840

ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 24900

aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 24960

aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 25020

tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 25080

cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 25140

gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 25200

cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 25260

tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 25320

ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 25380

agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 25440

gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 25500

atgctagcta actataacat tggctaccag ggcttctata tcccagagag ctacaaggac 25560

cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 25620

aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 25680

ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 25740

cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 25800

ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 25860

caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 25920

atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 25980

cagccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 26040

gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 26100

aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 26160

acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 26220

ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 26280

catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 26340

ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 26400

cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 26460

gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 26520

ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 26580

ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 26640

gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 26700

aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 26760

gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 26820

catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 26880

actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 26940

tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 27000

cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 27060

ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 27120

tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 27180

gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 27240

taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 27300

cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 27360

cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 27420

tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 27480

tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 27540

gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 27600

gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 27660

tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 27720

aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 27780

ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 27840

cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 27900

cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 27960

tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 28020

tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 28080

ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 28140

tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 28200

cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 28260

gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 28320

gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 28380

ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 28440

taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 28500

ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 28560

gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 28620

aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 28680

acctagatgt ggggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 28740

gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 28800

acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 28860

agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 28920

atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 28980

cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 29040

aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 29100

aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 29160

acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 29220

ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 29280

agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 29340

gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 29400

gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 29460

ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 29520

gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 29580

ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 29640

aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 29700

cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 29760

tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 29820

acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 29880

acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 29940

tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 30000

gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 30060

actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 30120

acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 30180

ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 30240

tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 30300

accacgccca cgagattagg ttctacgaag accaatcccg cccgcctaat gcggagctta 30360

ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 30420

gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 30480

agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 30540

cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 30600

tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 30660

tggggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 30720

ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 30780

acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 30840

gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 30900

caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 30960

caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 31020

gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 31080

ggcagcggca gcaacagcag cggccacaca gaagcaaagg cgaccggata gcaagactct 31140

gacaaagccc aagaaatcca cagcggcggc agcagcagga ggagggagcgc tgcgtctggc 31200

gcccaacgaa cccgtatcga cccgcgagct tagaaacagg atttttccca ctctgtatgc 31260

tatatttcaa cagagcaggg gccaagaaca agagctgaaa ataaaaaaca ggtctctgcg 31320

atccctcacc cgcagctgcc tgtatcacaa aagcgaagat cagcttcggc gcacgctgga 31380

agacgcggag gctctcttca gtaaatactg cgcgctgact cttaaggact agtttcgcgc 31440

cctttctcaa atttaagcgc gaaaactacg tcatctccag cggccacacc cggcgccagc 31500

acctgttgtc agcgccatta tgagcaagga aattcccacg ccctacatgt ggagttacca 31560

gccacaaatg ggacttgcgg ctggagctgc ccaagactac tcaacccgaa taaactacat 31620

gagcgcggga ccccacatga tatcccgggt caacggaata cgcgcccacc gaaaccgaat 31680

tctcctggaa caggcggcta ttaccaccac acctcgtaat aaccttaatc cccgtagttg 31740

gcccgctgcc ctggtgtacc aggaaagtcc cgctcccacc actgtggtac ttcccagaga 31800

cgcccaggcc gaagttcaga tgactaactc aggggcgcag cttgcgggcg gctttcgtca 31860

cagggtgcgg tcgcccgggc agggtataac tcacctgaca atcagagggc gaggtattca 31920

gctcaacgac gagtcggtga gctcctcgct tggtctccgt ccggacggga catttcagat 31980

cggcggcgcc ggccgctctt cattcacgcc tcgtcaggca atcctaactc tgcagacctc 32040

gtcctctgag ccgcgctctg gaggcattgg aactctgcaa tttattgagg agtttgtgcc 32100

atcggtctac tttaacccct tctcgggacc tcccggccac tatccggatc aatttattcc 32160

taactttgac gcggtaaagg actcggcgga cggctacgac tgaatgttaa gtggagaggc 32220

agagcaactg cgcctgaaac acctggtcca ctgtcgccgc cacaagtgct ttgcccgcga 32280

ctccggtgag ttttgctact ttgaattgcc cgaggatcat atcgagggcc cggcgcacgg 32340

cgtccggctt accgcccagg gagagcttgc ccgtagcctg attcgggagt ttacccagcg 32400

ccccctgcta gttgagcggg acaggggacc ctgtgttctc actgtgattt gcaactgtcc 32460

taaccctgga ttacatcaag atcctctagt taatgtcagg tcgcctaagt cgattaacta 32520

gagtacccgg ggatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 32580

ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 32640

cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 32700

tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 32760

cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 32820

cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 32880

ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 32940

gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 33000

gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 33060

gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 33120

gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 33180

agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 33240

ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 33300

actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 33360

ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 33420

gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 33480

ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 33540

tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 33600

aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 33660

tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 33720

ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 33780

gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 33840

catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 33900

tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 33960

accggaataa accctccacc taactgtcaa attgtggaaa acactaatac aaatgatggc 34020

aaacttactt tagtattagt aaaaaatgga gggcttgtta atggctacgt gtctctagtt 34080

ggtgtatcag acactgtgaa ccaaatgttc acacaaaaga cagcaaacat ccaattaaga 34140

ttatattttg actcttctgg aaatctatta actgaggaat cagacttaaa aattccactt 34200

aaaaataaat cttctacagc gaccagtgaa actgtagcca gcagcaaagc ctttatgcca 34260

agtactacag cttatccctt caacaccact actagggata gtgaaaacta cattcatgga 34320

atatgttact acatgactag ttatgataga agtctatttc ccttgaacat ttctataatg 34380

ctaaacagcc gtatgatttc ttccaatgtt gcctatgcca tacaatttga atggaatcta 34440

aatgcaagtg aatctccaga aagcaacata gctacgctga ccacatcccc ctttttcttt 34500

tcttacatta cagaagacga caactaaaga atcgtttgtg ttatgtttca acgtgtttat 34560

ttttcaattg cagaaaattt caagtcattt ttcattcagt agtatagccc caccaccaca 34620

tagcttatac agatcaccgt accttaatca aactcacaga accctagtat tcaacctgcc 34680

acctccctcc caacacacag agtacacagt cctttctccc cggctggcct taaaaagcat 34740

catatcatgg gtaacagaca tattcttagg tgttatattc cacacggttt cctgtcgagc 34800

caaacgctca tcagtgatat taataaactc cccggggcagc tcacttaagt tcatgtcgct 34860

gtccagctgc tgagccacag gctgctgtcc aacttgcggt tgcttaacgg gcggcgaagg 34920

agaagtccac gcctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg 34980

ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat 35040

ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg 35100

ggcacagcag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac 35160

aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac 35220

agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa 35280

cacgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca 35340

tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac 35400

ctgcccgccg gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca 35460

ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca 35520

cacgtgcata cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccagg 35580

aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact 35640

cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt 35700

agcgcgggtt tctgtctcaa aaggaggtag acgatcccta ctgtacggag tgcgccgaga 35760

caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt 35820

tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct 35880

tagatcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc 35940

tggcttcggg ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg 36000

cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag 36060

cgggaagagc tggaagaacc atgttttttt ttttattcca aaagattatc caaaacctca 36120

aaatgaagat ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc 36180

aaagaacaga taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc 36240

ctcacgtcca agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt 36300

ccagcacctt caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta 36360

agcaaatccc gaatattaag tccggccatt gtaaaaatct gctccagagc gccctccacc 36420

ttcagcctca agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa 36480

gattcaaaag cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca 36540

gctgaacata atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccadgaacca 36600

tgacaaaaga acccacactg attatgacac gcatactcgg agctatgcta accagcgtag 36660

ccccgatgta agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat 36720

caggcaaagc ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc 36780

aggtaagctc cggaaccacc acagaaaaag acaccatttt tctctcaaac atgtctgcgg 36840

gtttctgcat aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct 36900

tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc 36960

gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcatgtccgg 37020

agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa 37080

gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc 37140

cataggaggt ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc 37200

ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc 37260

agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac 37320

acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat 37380

aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 37440

aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt 37500

tttcccacgt tacgtcactt cccatttaa gaaaactaca attcccaaca catacaagtt 37560

actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 37620

tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg 37678

<210> 23

<211> 34739

<212> DNA

<213> Artificial sequence

<220>

<223> vector #1

<400> 23

catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tactgtaata gtaatcaatt 360

acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420

ggcccgcctg gctgaccgcc caacgacccc cgcccatga cgtcaataat gacgtatgtt 480

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660

acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720

tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt 780

gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840

aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900

agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020

agacaccggg accgatccag cctccgattt gccaccatgt ttgtgttcct ggtgctgctg 1080

ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc tcctgcctac 1140

accaactcct tcaccagggg agtctactac cctgacaagg tgttcaggtc ctctgtgctg 1200

cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt ccatgccatc 1260

catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc attcaatgat 1320

ggagtctact ttgccagcac agagaagagc aacatcatca ggggctggat ttttggcacc 1380

accctggaca gcaagacca gtccctgctg attgtgaaca atgccaccaa tgtggtgatt 1440

aaggtgtgtg agttccagtt ctgtaatgac ccattcctgg gagtctacta ccacaagaac 1500

aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa ctgtaccttt 1560

gaatatgtga gccaaccatt cctgatggac ttggagggca agcagggcaa cttcaagaac 1620

ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag caaacacaca 1680

ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc actggtggac 1740

ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca caggtcctac 1800

ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta ctatgtgggc 1860

tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat cacagatgct 1920

gtggactgtg ccctggaccc actngtctgag accaagtgta ccctgaaatc cttcacagtg 1980

gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag cattgtgagg 2040

tttccaaaca tcaccaacct gtgtccatt ggagaggtgt tcaatgccac caggtttgcc 2100

tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta ctctgtgctc 2160

tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac caaactgaat 2220

gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga tgaggtgaga 2280

cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact gcctgatgac 2340

ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt gggaggcaac 2400

tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga gagggacatc 2460

agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg cttcaactgt 2520

tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta ccaaccatac 2580

agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgtg tggaccaaag 2640

aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg actgacaggc 2700

acaggagtgc tgacagagag caacaagaag ttcctgccat tccaacagtt tggcagggac 2760

attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct ggacatcaca 2820

ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag caaccaggtg 2880

gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca tgctgaccaa 2940

cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac cagggctggc 3000

tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc aattggagca 3060

ggcatctgtg cctcctacca gacccagacc aacagcccaa ggagggcaag gtctgtggca 3120

agccagagca tcattgccta cacaatgagt ctgggagcag agaactctgt ggcttacagc 3180

aacaacagca ttgccatccc aaccaacttc accatctctg tgaccacaga gattctgcct 3240

gtgagtatga ccaagacctc tgtggactgt acaatgtata tctgtggaga cagcacagag 3300

tgtagcaacc tgctgctcca atatggctcc ttctgtaccc aacttaacag ggctctgaca 3360

ggcattgctg tggaacagga caagaacacc caggaggtgt ttgcccaggt gaagcagatt 3420

tacaagacac ctccaatcaa ggactttgga ggcttcaact tcagccagat tctgcctgac 3480

ccaagcaagc caagcaagag gtccttcatt gaggacctgc tgttcaacaa ggtgaccctg 3540

gctgatgctg gcttcatcaa gcaatatgga gactgtctgg gagacattgc tgccagggac 3600

ctgatttgtg cccagaagtt caatggactg acagtgctgc ctccactgct gacagatgag 3660

atgattgccc aatacacctc tgccctgctg gctggcacca tcacctctgg ctggaccttt 3720

ggagcaggag cagccctcca aatcccattt gctatgcaga tggcttacag gttcaatggc 3780

attggagtga cccagaatgt gctctatgag aaccagaaac tgattgccaa ccagttcaac 3840

tctgccattg gcaagattca ggactccctg tccagcacag cctctgccct gggcaaactc 3900

caagatgtgg tgaaccagaa tgcccaggct ctgaacaccc tggtgaagca actttccagc 3960

aactttggag ccatctcctc tgtgctgaat gacatcctga gcagactgga caaggtggag 4020

gctgaggtcc agattgacag actgattaca ggcagactcc aatccctcca aacctatgtg 4080

acccaacaac ttatcagggc tgctgagatt agggcatctg ccaacctggc tgccaccaag 4140

atgagtgagt gtgtgctggg acaaagcaag agggtggact tctgtggcaa gggctaccac 4200

ctgatgagtt ttccacagtc tgcccctcat ggagtggtgt tcctgcatgt gacctatgtg 4260

cctgcccagg agaagaactt caccacagcc cctgccatct gccatgatgg caaggctcac 4320

tttccaaggg agggagtgtt tgtgagcaat ggcacccact ggtttgtgac cccaggaac 4380

ttctatgaac cacagattat caccacagac aacacctttg tgtctggcaa ctgtgatgtg 4440

gtgattggca ttgtgaacaa cacagtctat gacccactcc aacctgaact ggactccttc 4500

aaggaggaac tggacaaata cttcaagaac cacaccagcc ctgatgtgga cctggggagac 4560

atctctggca tcaatgcctc tgtggtgaac atccagaagg agattgacag actgaatgag 4620

gtggctaaga acctgaatga gtccctgatt gacctccaag aactgggcaa atatgaacaa 4680

tacatcaagt ggccatgaaa attgatcata atcagccata ccacatttgt agaggtttta 4740

cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 4800

gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 4860

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 4920

aatgtatctt aacgcggatc tgggcgtggt taagggtggg aaagaatata taaggtgggg 4980

gtcttatgta gttttgtatc tgttttgcag cagccgccgc cgccatgagc accaactcgt 5040

ttgatggaag cattgtgagc tcatatttga caacgcgcat gcccccatgg gccggggtgc 5100

gtcagaatgt gatgggctcc agcattgatg gtcgccccgt cctgcccgca aactctacta 5160

ccttgaccta cgagaccgtg tctggaacgc cgttggagac tgcagcctcc gccgccgctt 5220

cagccgctgc agccaccgcc cgcgggattg tgactgactt tgctttcctg agcccgcttg 5280

caagcagtgc agcttcccgt tcatccgccc gcgatgacaa gttgacggct cttttggcac 5340

aattggattc tttgacccgg gaacttaatg tcgtttctca gcagctgttg gatctgcgcc 5400

agcaggtttc tgccctgaag gcttcctccc ctcccaatgc ggtttaaaac ataaataaaa 5460

aaccagactc tgtttggatt tggatcaagc aagtgtcttg ctgtctttat ttaggggttt 5520

tgcgcgcgcg gtaggcccgg gaccagcggt ctcggtcgtt gagggtcctg tgtatttttt 5580

ccaggacgtg gtaaaggtga ctctggatgt tcagatacat gggcataagc ccgtctctgg 5640

ggtggaggta gcaccactgc agagcttcat gctgcggggt ggtgttgtag atgatccagt 5700

cgtagcagga gcgctgggcg tggtgcctaa aaatgtcttt cagtagcaag ctgattgcca 5760

ggggcaggcc cttggtgtaa gtgtttacaa agcggttaag ctgggatggg tgcatacgtg 5820

gggatatgag atgcatcttg gactgtattt ttaggttggc tatgttccca gccatatccc 5880

tccggggatt catgttgtgc agaaccacca gcacagtgta tccggtgcac ttgggaaatt 5940

tgtcatgtag cttagaagga aatgcgtgga agaacttgga gacgcccttg tgacctccaa 6000

gattttccat gcattcgtcc ataatgatgg caatgggccc acgggcggcg gcctgggcga 6060

agatatttct gggatcacta acgtcatagt tgtgttccag gatgagatcg tcataggcca 6120

tttttacaaa gcgcgggcgg agggtgccag actgcggtat aatggttcca tccggcccag 6180

gggcgtagtt accctcacag atttgcattt cccacgcttt gagttcagat ggggggatca 6240

tgtctacctg cggggcgatg aagaaaacgg tttccggggt aggggagatc agctgggaag 6300

aaagcaggtt cctgagcagc tgcgacttac cgcagccggt gggcccgtaa atcacaccta 6360

ttaccggctg caactggtag ttaagagagc tgcagctgcc gtcatccctg agcagggggg 6420

ccacttcgtt aagcatgtcc ctgactcgca tgttttccct gaccaaatcc gccagaaggc 6480

gctcgccgcc cagcgatagc agttcttgca aggaagcaaa gtttttcaac ggtttgagac 6540

cgtccgccgt aggcatgctt ttgagcgttt gaccaagcag ttccaggcgg tcccacagct 6600

cggtcacctg ctctacggca tctcgatcca gcatatctcc tcgtttcgcg ggttggggcg 6660

gctttcgctg tacggcagta gtcggtgctc gtccagacgg gccagggtca tgtctttcca 6720

cgggcgcagg gtcctcgtca gcgtagtctg ggtcacggtg aaggggtgcg ctccgggctg 6780

cgcgctggcc agggtgcgct tgaggctggt cctgctggtg ctgaagcgct gccggtcttc 6840

gccctgcgcg tcggccaggt agcatttgac catggtgtca tagtccagcc cctccgcggc 6900

gtggcccttg gcgcgcagct tgcccttgga ggaggcgccg cacgaggggc agtgcagact 6960

tttgagggcg tagagcttgg gcgcgagaaa taccgattcc ggggagtagg catccgcgcc 7020

gcaggccccg cagacggtct cgcattccac gagccaggtg agctctggcc gttcggggtc 7080

aaaaaccagg tttcccccat gctttttgat gcgtttctta cctctggttt ccatgagccg 7140

gtgtccacgc tcggtgacga aaaggctgtc cgtgtccccg tatacagact tgagaggcct 7200

gtcctcgagc ggtgttccgc ggtcctcctc gtatagaaac tcggaccact ctgagacaaa 7260

ggctcgcgtc caggccagca cgaaggaggc taagtgggag gggtagcggt cgttgtccac 7320

tagggggtcc actcgctcca gggtgtgaag acacatgtcg ccctcttcgg catcaaggaa 7380

ggtgattggt ttgtaggtgt aggccacgtg accgggtgtt cctgaagggg ggctataaaa 7440

gggggtgggg gcgcgttcgt cctcactctc ttccgcatcg ctgtctgcga gggccagctg 7500

ttggggtgag tactccctct gaaaagcggg catgacttct gcgctaagat tgtcagtttc 7560

caaaaacgag gaggatttga tattcacctg gcccgcggtg atgcctttga gggtggccgc 7620

atccatctgg tcagaaaaga caatcttttt gttgtcaagc ttggtggcaa acgacccgta 7680

gagggcgttg gacagcaact tggcgatgga gcgcagggtt tggtttttgt cgcgatcggc 7740

gcgctccttg gccgcgatgt ttagctgcac gtattcgcgc gcaacgcacc gccattcggg 7800

aaagacggtg gtgcgctcgt cgggcaccag gtgcacgcgc caaccgcggt tgtgcagggt 7860

gacaaggtca acgctggtgg ctacctctcc gcgtaggcgc tcgttggtcc agcagaggcg 7920

gccgcccttg cgcgagcaga atggcggtag ggggtctagc tgcgtctcgt ccggggggtc 7980

tgcgtccacg gtaaagaccc cgggcagcag gcgcgcgtcg aagtagtcta tcttgcatcc 8040

ttgcaagtct agcgcctgct gccatgcgcg ggcggcaagc gcgcgctcgt atgggttgag 8100

tggggggaccc catggcatgg ggtgggtgag cgcggaggcg tacatgccgc aaatgtcgta 8160

aacgtagagg ggctctctga gtattccaag atatgtaggg tagcatcttc caccgcggat 8220

gctggcgcgc acgtaatcgt atagttcgtg cgagggagcg aggaggtcgg gaccgaggtt 8280

gctacgggcg ggctgctctg ctcggaagac tatctgcctg aagatggcat gtgagttgga 8340

tgatatggtt ggacgctgga agacgttgaa gctggcgtct gtgagaccta ccgcgtcacg 8400

cacgaaggag gcgtaggagt cgcgcagctt gttgaccagc tcggcggtga cctgcacgtc 8460

tagggcgcag tagtccagg tttccttgat gatgtcatac ttatcctgtc cctttttttt 8520

ccacagctcg cggttgagga caaactcttc gcggtctttc cagtactctt ggatcggaaa 8580

cccgtcggcc tccgaacggt aagagcctag catgtagaac tggttgacgg cctggtaggc 8640

gcagcatccc ttttctacgg gtagcgcgta tgcctgcgcg gccttccgga gcgaggtgtg 8700

ggtgagcgca aaggtgtccc tgaccatgac tttgaggtac tggtatttga agtcagtgtc 8760

gtcgcatccg ccctgctccc agagcaaaaa gtccgtgcgc tttttggaac gcggatttgg 8820

cagggcgaag gtgacatcgt tgaagagtat ctttcccgcg cgaggcataa agttgcgtgt 8880

gatgcggaag ggtcccggca cctcggaacg gttgttaatt acctgggcgg cgagcacgat 8940

ctcgtcaaag ccgttgatgt tgtggcccac aatgtaaagt tccaagaagc gcgggatgcc 9000

cttgatggaa ggcaattttt taagttcctc gtaggtgagc tcttcagggg agctgagccc 9060

gtgctctgaa agggcccagt ctgcaagatg agggttggaa gcgacgaatg agctccacag 9120

gtcacgggcc attagcattt gcaggtggtc gcgaaaggtc ctaaactggc gacctatggc 9180

cattttttct ggggtgatgc agtagaaggt aagcgggtct tgttcccagc ggtcccatcc 9240

aaggttcgcg gctaggtctc gcgcggcagt cactagaggc tcatctccgc cgaacttcat 9300

gaccagcatg aagggcacga gctgcttccc aaaggccccc atccaagtat aggtctctac 9360

atcgtaggtg acaaagagac gctcggtgcg aggatgcgag ccgatcggga agaactggat 9420

ctcccgccac caattggagg agtggctatt gatgtggtga aagtagaagt ccctgcgacg 9480

ggccgaacac tcgtgctggc ttttgtaaaa acgtgcgcag tactggcagc ggtgcacggg 9540

ctgtacatcc tgcacgaggt tgacctgacg accgcgcaca aggaagcaga gtgggaattt 9600

gagcccctcg cctggcgggt ttggctggtg gtcttctact tcggctgctt gtccttgacc 9660

gtctggctgc tcgaggggag ttacggtgga tcggaccacc acgccgcgcg agcccaaagt 9720

ccagatgtcc gcgcgcggcg gtcggagctt gatgacaaca tcgcgcagat gggagctgtc 9780

catggtctgg agctcccgcg gcgtcaggtc aggcgggagc tcctgcaggt ttacctcgca 9840

tagacgggtc agggcgcggg ctagatccag gtgataccta atttccaggg gctggttggt 9900

ggcggcgtcg atggcttgca agaggccgca tccccgcggc gcgactacgg taccgcgcgg 9960

cgggcggtgg gccgcggggg tgtccttgga tgatgcatct aaaagcggtg acgcgggcga 10020

gcccccggag gtaggggggg ctccggaccc gccgggagag ggggcagggg cacgtcggcg 10080

ccgcgcgcgg gcaggagctg gtgctgcgcg cgtaggttgc tggcgaacgc gacgacgcgg 10140

cggttgatct cctgaatctg gcgcctctgc gtgaagacga cgggcccggt gagcttgaac 10200

ctgaaagaga gttcgacaga atcaatttcg gtgtcgttga cggcggcctg gcgcaaaatc 10260

tcctgcacgt ctcctgagtt gtcttgatag gcgatctcgg ccatgaactg ctcgatctct 10320

tcctcctgga gatctccgcg tccggctcgc tccacggtgg cggcgaggtc gttggaaatg 10380

cgggccatga gctgcgagaa ggcgttgagg cctccctcgt tccagacgcg gctgtagacc 10440

acgccccctt cggcatcgcg ggcgcgcatg accacctgcg cgagattgag ctccacgtgc 10500

cgggcgaaga cggcgtagtt tcgcaggcgc tgaaagaggt agttgaggt ggtggcggtg 10560

tgttctgcca cgaagaagta cataacccag cgtcgcaacg tggattcgtt gatatccccc 10620

aaggcctcaa ggcgctccat ggcctcgtag aagtccacgg cgaagttgaa aaactgggag 10680

ttgcgcgccg acacggttaa ctcctcctcc agaagacgga tgagctcggc gacagtgtcg 10740

cgcacctcgc gctcaaaggc tacaggggcc tcttcttctt cttcaatctc ctcttccata 10800

agggcctccc cttcttcttc ttctggcggc ggtgggggag gggggacacg gcggcgacga 10860

cggcgcaccg ggaggcggtc gacaaagcgc tcgatcatct ccccgcggcg acggcgcatg 10920

gtctcggtga cggcgcggcc gttctcgcgg gggcgcagtt ggaagacgcc gcccgtcatg 10980

tcccggttat gggttggcgg ggggctgcca tgcggcaggg atacggcgct aacgatgcat 11040

ctcaacaatt gttgtgtagg tactccgccg ccgagggacc tgagcgagtc cgcatcgacc 11100

ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg taggctgagc 11160

accgtggcgg gcggcagcgg gcggcggtcg gggttgtttc tggcggaggt gctgctgatg 11220

atgtaattaa agtaggcggt cttgagacgg cggatggtcg acagaagcac catgtccttg 11280

ggtccggcct gctgaatgcg caggcggtcg gccatgcccc aggcttcgtt ttgacatcgg 11340

cgcaggtctt tgtagtagtc ttgcatgagc ctttctaccg gcacttcttc ttctccttcc 11400

tcttgtcctg catctcttgc atctatcgct gcggcggcgg cggagtttgg ccgtaggtgg 11460

cgccctcttc ctcccatgcg tgtgaccccg aagcccctca tcggctgaag cagggctagg 11520

tcggcgacaa cgcgctcggc taatatggcc tgctgcacct gcgtgaggt agactggaag 11580

tcatccatgt ccacaaagcg gtggtatgcg cccgtgttga tggtgtaagt gcagttggcc 11640

ataacggacc agttaacggt ctggtgaccc ggctgcgaga gctcggtgta cctgagacgc 11700

gagtaagccc tcgagtcaaa tacgtagtcg ttgcaagtcc gcaccaggta ctggtatccc 11760

accaaaaagt gcggcggcgg ctggcggtag aggggccagc gtagggtggc cggggctccg 11820

ggggcgagat cttccaacat aaggcgatga tatccgtaga tgtacctgga catccaggtg 11880

atgccggcgg cggtggtgga ggcgcgcgga aagtcgcgga cgcggttcca gatgttgcgc 11940

agcggcaaaa agtgctccat ggtcgggacg ctctggccgg tcaggcgcgc gcaatcgttg 12000

acgctctagc gtgcaaaagg agagcctgta agcgggcact cttccgtggt ctggtggata 12060

aattcgcaag ggtatcatgg cggacgaccg gggttcgagc cccgtatccg gccgtccgcc 12120

gtgatccatg cggttaccgc ccgcgtgtcg aacccaggtg tgcgacgtca gacaacgggg 12180

gagtgctcct tttggcttcc ttccaggcgc ggcggctgct gcgctagctt ttttggccac 12240

tggccgcgcg cagcgtaagc ggttaggctg gaaagcgaaa gcattaagtg gctcgctccc 12300

tgtagccgga gggttatttt ccaagggttg agtcgcggga cccccggttc gagtctcgga 12360

ccggccggac tgcggcgaac gggggtttgc ctccccgtca tgcaagaccc cgcttgcaaa 12420

ttcctccgga aacagggacg agcccctttt ttgcttttcc cagatgcatc cggtgctgcg 12480

gcagatgcgc ccccctcctc agcagcggca agagcaagag cagcggcaga catgcagggc 12540

accctcccct cctcctaccg cgtcaggagg ggcgacatcc gcggttgacg cggcagcaga 12600

tggtgattac gaacccccgc ggcgccgggc ccggcactac ctggacttgg aggagggcga 12660

gggcctggcg cggctaggag cgccctctcc tgagcggcac ccaagggtgc agctgaagcg 12720

tgatacgcgt gaggcgtacg tgccgcggca gaacctgttt cgcgaccgcg agggagga 12780

gcccgaggag atgcgggatc gaaagttcca cgcagggcgc gagctgcggc atggcctgaa 12840

tcgcgagcgg ttgctgcgcg aggaggactt tgagcccgac gcgcgaaccg ggattagtcc 12900

cgcgcgcgca cacgtggcgg ccgccgacct ggtaaccgca tacgagcaga cggtgaacca 12960

ggagattaac tttcaaaaaa gctttaacaa ccacgtgcgt acgcttgtgg cgcgcgagga 13020

ggtggctata ggactgatgc atctgtggga ctttgtaagc gcgctggagc aaaacccaaa 13080

tagcaagccg ctcatggcgc agctgttcct tatagtgcag cacagcaggg acaacgaggc 13140

attcagggat gcgctgctaa acatagtaga gcccgagggc cgctggctgc tcgatttgat 13200

aaacatcctg cagagcatag tggtgcagga gcgcagcttg agcctggctg acaaggtggc 13260

cgccatcaac tattccatgc ttagcctggg caagttttac gcccgcaaga tataccatac 13320

cccttacgtt cccatagaca aggaggtaaa gatcgagggg ttctacatgc gcatggcgct 13380

gaaggtgctt accttgagcg acgacctggg cgtttatcgc aacgagcgca tccacaaggc 13440

cgtgagcgtg agccggcggc gcgagctcag cgaccgcgag ctgatgcaca gcctgcaaag 13500

ggccctggct ggcacgggca gcggcgatag agaggccgag tcctactttg acgcgggcgc 13560

tgacctgcgc tgggccccaa gccgacgcgc cctggaggca gctggggccg gacctgggct 13620

ggcggtggca cccgcgcgcg ctggcaacgt cggcggcgtg gaggaatatg acgaggacga 13680

tgagtacgag ccagaggacg gcgagtacta agcggtgatg tttctgatca gatgatgcaa 13740

gacgcaacgg acccggcggt gcgggcggcg ctgcagagcc agccgtccgg ccttaactcc 13800

acggacgact ggcgccaggt catggaccgc atcatgtcgc tgactgcgcg caatcctgac 13860

gcgttccggc agcagccgca ggccaaccgg ctctccgcaa ttctggaagc ggtggtcccg 13920

gcgcgcgcaa accccacgca cgagaaggtg ctggcgatcg taaacgcgct ggccgaaaac 13980

agggccatcc ggcccgacga ggccggcctg gtctacgacg cgctgcttca gcgcgtggct 14040

cgttacaaca gcggcaacgt gcagaccaac ctggaccggc tggtggggga tgtgcgcgag 14100

gccgtggcgc agcgtgagcg cgcgcagcag cagggcaacc tgggctccat ggttgcacta 14160

aacgccttcc tgagtacaca gcccgccaac gtgccgcggg gacaggagga ctacaccaac 14220

tttgtgagcg cactgcggct aatggtgact gagacaccgc aaagtgaggt gtaccagtct 14280

gggccagact attttttcca gaccagtaga caaggcctgc agaccgtaaa cctgagccag 14340

gctttcaaaa acttgcaggg gctgtggggg gtgcgggctc ccacaggcga ccgcgcgacc 14400

gtgtctagct tgctgacgcc caactcgcgc ctgttgctgc tgctaatagc gcccttcacg 14460

gacagtggca gcgtgtcccg ggacacatac ctaggtcact tgctgacact gtaccgcgag 14520

gccataggtc aggcgcatgt ggacgagcat actttccagg agattacaag tgtcagccgc 14580

gcgctggggc aggaggacac gggcagcctg gaggcaaccc taaactacct gctgaccaac 14640

cggcggcaga agatcccctc gttgcacagt ttaaacagcg aggaggagcg cattttgcgc 14700

tacgtgcagc agagcgtgag ccttaacctg atgcgcgacg gggtaacgcc cagcgtggcg 14760

ctggacatga ccgcgcgcaa catggaaccg ggcatgtatg cctcaaaccg gccgtttatc 14820

aaccgcctaa tggactactt gcatcgcgcg gccgccgtga accccgagta tttcaccaat 14880

gccatcttga acccgcactg gctaccgccc cctggtttct acaccggggg attcgaggtg 14940

cccgaggta acgatggatt cctctgggac gacatagacg acagcgtgtt ttccccgcaa 15000

ccgcagaccc tgctagagtt gcaacagcgc gagcaggcag aggcggcgct gcgaaaggaa 15060

agcttccgca ggccaagcag cttgtccgat ctaggcgctg cggccccgcg gtcagatgct 15120

agtagcccat ttccaagctt gatagggtct cttaccagca ctcgcaccac ccgcccgcgc 15180

ctgctgggcg aggaggagta cctaaacaac tcgctgctgc agccgcagcg cgaaaaaaac 15240

ctgcctccgg catttcccaa caacgggata gagagcctag tggacaagat gagtagatgg 15300

aagacgtacg cgcaggagca cagggacgtg ccaggcccgc gcccgcccac ccgtcgtcaa 15360

aggcacgacc gtcagcgggg tctggtgtgg gaggacgatg actcggcaga cgacagcagc 15420

gtcctggatt tgggagggag tggcaacccg tttgcgcacc ttcgccccag gctggggaga 15480

atgttttaaa aaaaaaaaag catgatgcaa aataaaaaac tcaccaaggc catggcaccg 15540

agcgttggtt ttcttgtatt ccccttagta tgcggcgcgc ggcgatgtat gaggaaggtc 15600

ctcctccctc ctacgagagt gtggtgagcg cggcgccagt ggcggcggcg ctgggttctc 15660

ccttcgatgc tcccctggac ccgccgtttg tgcctccgcg gtacctgcgg cctaccgggg 15720

ggagaaacag catccgttac tctgagttgg cacccctatt cgacaccacc cgtgtgtacc 15780

tggtggacaa caagtcaacg gatgtggcat ccctgaacta ccagaacgac cacagcaact 15840

ttctgaccac ggtcattcaa aacaatgact acagcccggg ggaggcaagc acacagacca 15900

tcaatcttga cgaccggtcg cactggggcg gcgacctgaa aaccatcctg cataccaaca 15960

tgccaaatgt gaacgagttc atgtttacca ataagtttaa ggcgcgggtg atggtgtcgc 16020

gcttgcctac taaggacaat caggtggagc tgaaatacga gtgggtggag ttcacgctgc 16080

ccgagggcaa ctactccgag accatgacca tagaccttat gaacaacgcg atcgtggagc 16140

actacttgaa agtgggcaga cagaacgggg ttctggaaag cgacatcggg gtaaagtttg 16200

acacccgcaa cttcagactg gggtttgacc ccgtcactgg tcttgtcatg cctggggtat 16260

atacaaacga agccttccat ccagacatca ttttgctgcc aggatgcggg gtggacttca 16320

cccacagccg cctgagcaac ttgttgggca tccgcaagcg gcaacccttc caggagggct 16380

ttaggatcac ctacgatgat ctggagggtg gtaacattcc cgcactgttg gatgtggacg 16440

cctaccaggc gagcttgaaa gatgacaccg aacagggcgg gggtggcgca ggcggcagca 16500

acagcagtgg cagcggcgcg gaagagaact ccaacgcggc agccgcggca atgcagccgg 16560

tggaggacat gaacgatcat gccattcgcg gcgacacctt tgccacacgg gctgaggaga 16620

agcgcgctga ggccgaagca gcggccgaag ctgccgcccc cgctgcgcaa cccgaggtcg 16680

agaagcctca gaagaaaccg gtgatcaaac ccctgacaga ggacagcaag aaacgcagtt 16740

acaacctaat aagcaatgac agcaccttca cccagtaccg cagctggtac cttgcataca 16800

actacggcga ccctcagacc ggaatccgct catggaccct gctttgcact cctgacgtaa 16860

cctgcggctc ggagcaggtc tactggtcgt tgccagacat gatgcaagac cccgtgacct 16920

tccgctccac gcgccagatc agcaactttc cggtggtggg cgccgagctg ttgcccgtgc 16980

actccaagag cttctacaac gaccaggccg tctactccca actcatccgc cagtttacct 17040

ctctgaccca cgtgttcaat cgctttcccg agaaccagat tttggcgcgc ccgccagccc 17100

cccacatcac caccgtcagt gaaaacgttc ctgctctcac agatcacggg acgctaccgc 17160

tgcgcaacag catcggagga gtccagcgag tgaccattac tgacgccaga cgccgcacct 17220

gcccctacgt ttacaaggcc ctgggcatag tctcgccgcg cgtcctatcg agccgcactt 17280

tttgagcaag catgtccatc cttatatcgc ccagcaataa cacaggctgg ggcctgcgct 17340

tcccaagcaa gatgtttggc ggggccaaga agcgctccga ccaacaccca gtgcgcgtgc 17400

gcgggcacta ccgcgcgccc tggggcgcgc acaaacgcgg ccgcactggg cgcaccaccg 17460

tcgatgacgc catcgacgcg gtggtggagg aggcgcgcaa ctacacgccc acgccgccac 17520

cagtgtccac agtggacgcg gccattcaga ccgtggtgcg cggagcccgg cgctatgcta 17580

aaatgaagag acggcggagg cgcgtagcac gtcgccaccg ccgccgaccc ggcactgccg 17640

cccaacgcgc ggcggcggcc ctgcttaacc gcgcacgtcg caccggccga cgggcggcca 17700

tgcgggccgc tcgaaggctg gccgcgggta ttgtcactgt gccccccagg tccaggcgac 17760

gagcggccgc cgcagcagcc gcggccatta gtgctatgac tcagggtcgc aggggcaacg 17820

tgtattgggt gcgcgactcg gttagcggcc tgcgcgtgcc cgtgcgcacc cgccccccgc 17880

gcaactagat tgcaagaaaa aactacttag actcgtactg ttgtatgtat ccagcggcgg 17940

cggcgcgcaa cgaagctatg tccaagcgca aaatcaaaga agagatgctc caggtcatcg 18000

cgccggagat ctatggcccc ccgaagaagg aagagcagga ttacaagccc cgaaagctaa 18060

agcgggtcaa aaagaaaaag aaagatgatg atgatgaact tgacgacgag gtggaactgc 18120

tgcacgctac cgcgcccagg cgacgggtac agtggaaagg tcgacgcgta aaacgtgttt 18180

tgcgacccgg caccaccgta gtctttacgc ccggtgagcg ctccacccgc acctacaagc 18240

gcgtgtatga tgaggtgtac ggcgacgagg acctgcttga gcaggccaac gagcgcctcg 18300

gggagtttgc ctacggaaag cggcataagg acatgctggc gttgccgctg gacgagggca 18360

acccaacacc tagcctaaag cccgtaacac tgcagcaggt gctgcccgcg cttgcaccgt 18420

ccgaagaaaa gcgcggccta aagcgcgagt ctggtgactt ggcacccacc gtgcagctga 18480

tggtacccaa gcgccagcga ctggaagatg tcttggaaaa aatgaccgtg gaacctgggc 18540

tggagcccga ggtccgcgtg cggccaatca agcaggtggc gccgggactg ggcgtgcaga 18600

ccgtggacgt tcagataccc actaccagta gcaccagtat tgccaccgcc agagggca 18660

tggagacaca aacgtccccg gttgcctcag cggtggcgga tgccgcggtg caggcggtcg 18720

ctgcggccgc gtccaagacc tctacggagg tgcaaacgga cccgtggatg tttcgcgttt 18780

cagccccccg gcgcccgcgc cgttcgagga agtacggcgc cgccagcgcg ctactgcccg 18840

aatatgccct acatccttcc attgcgccta cccccggcta tcgtggctac acctaccgcc 18900

ccagaagacg agcaactacc cgacgccgaa ccaccactgg aacccgccgc cgccgtcgcc 18960

gtcgccagcc cgtgctggcc ccgatttccg tgcgcagggt ggctcgcgaa ggaggcagga 19020

ccctggtgct gccaacagcg cgctaccacc ccagcatcgt ttaaaagccg gtctttgtgg 19080

ttcttgcaga tatggccctc acctgccgcc tccgtttccc ggtgccggga ttccgaggaa 19140

gaatgcaccg taggaggggc atggccggcc acggcctgac gggcggcatg cgtcgtgcgc 19200

accaccggcg gcggcgcgcg tcgcaccgtc gcatgcgcgg cggtatcctg cccctcctta 19260

ttccactgat cgccgcggcg attggcgccg tgcccggaat tgcatccgtg gccttgcagg 19320

cgcagagaca ctgattaaaa acaagttgca tgtggaaaaa tcaaaataaa aagtctggac 19380

tctcacgctc gcttggtcct gtaactattt tgtagaatgg aagacatcaa ctttgcgtct 19440

ctggccccgc gacacggctc gcgcccgttc atgggaaact ggcaagatat cggcaccagc 19500

aatatgagcg gtggcgcctt cagctggggc tcgctgtgga gcggcattaa aaatttcggt 19560

tccaccgtta agaactatgg cagcaaggcc tggaacagca gcacaggcca gatgctgagg 19620

gataagttga aagagcaaaa tttccaacaa aaggtggtag atggcctggc ctctggcatt 19680

agcggggtgg tggacctggc caaccaggca gtgcaaaata agattaacag taagcttgat 19740

ccccgccctc ccgtagagga gcctccaccg gccgtggaga cagtgtctcc agaggggcgt 19800

ggcgaaaagc gtccgcgccc cgacagggaa gaaactctgg tgacgcaaat agacgagcct 19860

ccctcgtacg aggaggcact aaagcaaggc ctgcccacca cccgtcccat cgcgcccatg 19920

gctaccggag tgctgggcca gcacacaccc gtaacgctgg acctgcctcc ccccgccgac 19980

acccagcaga aacctgtgct gccaggcccg accgccgttg ttgtaacccg tcctagccgc 20040

gcgtccctgc gccgcgccgc cagcggtccg cgatcgttgc ggcccgtagc cagtggcaac 20100

tggcaaagca cactgaacag catcgtgggt ctggggggtgc aatccctgaa gcgccgacga 20160

tgcttctgat agctaacgtg tcgtatgtgt gtcatgtatg cgtccatgtc gccgccagag 20220

gagctgctga gccgccgcgc gcccgctttc caagatggct accccttcga tgatgccgca 20280

gtggtcttac atgcacatct cgggccagga cgcctcggag tacctgagcc ccgggctggt 20340

gcagtttgcc cgcgccaccg agacgtactt cagcctgaat aacaagttta gaaaccccac 20400

ggtggcgcct acgcacgacg tgaccacaga ccggtcccag cgtttgacgc tgcggttcat 20460

ccctgtggac cgtgaggata ctgcgtactc gtacaaggcg cggttcaccc tagctgtggg 20520

tgataaccgt gtgctggaca tggcttccac gtactttgac atccgcggcg tgctggacag 20580

gggccctact tttaagccct actctggcac tgcctacaac gccctggctc ccaagggtgc 20640

cccaaatcct tgcgaatggg atgaagctgc tactgctctt gaaataaacc tagaagaaga 20700

ggacgatgac aacgaagacg aagtagacga gcaagctgag cagcaaaaaa ctcacgtatt 20760

tgggcaggcg ccttattctg gtataaatat tacaaaggag ggtattcaaa taggtgtcga 20820

aggtcaaaca cctaaatatg ccgataaaac atttcaacct gaacctcaaa taggagaatc 20880

tcagtggtac gaaacagaaa ttaatcatgc agctgggaga gtcctaaaaa agactacccc 20940

aatgaaacca tgttacggtt catatgcaaa acccacaaat gaaaatggag ggcaaggcat 21000

tcttgtaaag caacaaaatg gaaagctaga aagtcaagtg gaaatgcaat ttttctcaac 21060

tactgaggca gccgcaggca atggtgataa cttgactcct aaagtggtat tgtacagtga 21120

agatgtagat atagaaaccc cagacactca tatttcttac atgcccacta ttaaggaagg 21180

taactcacga gaactaatgg gccaacaatc tatgcccaac aggcctaatt acattgcttt 21240

tagggacaat tttattggtc taatgtatta caacagcacg ggtaatatgg gtgttctggc 21300

gggccaagca tcgcagttga atgctgttgt agatttgcaa gacagaaaca cagagctttc 21360

ataccagctt ttgcttgatt ccattggtga tagaaccagg tacttttcta tgtggaatca 21420

ggctgttgac agctatgatc cagatgttag aattattgaa aatcatggaa ctgaagatga 21480

acttccaaat tactgctttc cactgggagg tgtgattaat acagagactc ttaccaaggt 21540

aaaacctaaa acaggtcagg aaaatggatg ggaaaaagat gctacagaat tttcagataa 21600

aaatgaaata agagttggaa ataattttgc catggaaatc aatctaaatg ccaacctgtg 21660

gagaaatttc ctgtactcca acatagcgct gtatttgccc gacaagctaa agtacagtcc 21720

ttccaacgta aaaatttctg ataacccaaa cacctacgac tacatgaaca agcgagtggt 21780

ggctcccggg ctagtggact gctacattaa ccttggagca cgctggtccc ttgactatat 21840

ggacaacgtc aacccattta accaccaccg caatgctggc ctgcgctacc gctcaatgtt 21900

gctgggcaat ggtcgctatg tgcccttcca catccaggtg cctcagaagt tctttgccat 21960

taaaaacctc cttctcctgc cgggctcata cacctacgag tggaacttca ggaaggatgt 22020

taacatggtt ctgcagagct ccctaggaaa tgacctaagg gttgacggag ccagcattaa 22080

gtttgatagc atttgccttt acgccacctt cttccccatg gcccacaaca ccgcctccac 22140

gcttgaggcc atgcttagaa acgacaccaa cgaccagtcc tttaacgact atctctccgc 22200

cgccaacatg ctctacccta tacccgccaa cgctaccaac gtgcccatat ccatcccctc 22260

ccgcaactgg gcggctttcc gcggctgggc cttcacgcgc cttaagacta aggaaacccc 22320

atcactgggc tcgggctacg acccttatta cacctactct ggctctatac cctacctaga 22380

tggaaccttt tacctcaacc acacctttaa gaaggtggcc attacctttg actcttctgt 22440

cagctggcct ggcaatgacc gcctgcttac ccccaacgag tttgaaatta agcgctcagt 22500

tgacggggag ggttacaacg ttgcccagtg taacatgacc aaagactggt tcctggtaca 22560

aatgctagct aactataaca ttggctacca gggcttctat atcccagaga gctacaagga 22620

ccgcatgtac tccttcttta gaaacttcca gcccatgagc cgtcaggtgg tggatgatac 22680

taaatacaag gactaccaac aggtgggcat cctacaccaa cacaacaact ctggatttgt 22740

tggctacctt gcccccacca tgcgcgaagg acaggcctac cctgctaact tcccctatcc 22800

gcttataggc aagaccgcag ttgacagcat tacccagaaa aagtttcttt gcgatcgcac 22860

cctttggcgc atcccattct ccagtaactt tatgtccatg ggcgcactca cagacctggg 22920

ccaaaacctt ctctacgcca actccgccca cgcgctagac atgacttttg aggtggatcc 22980

catggacgag cccacccttc tttatgtttt gtttgaagtc tttgacgtgg tccgtgtgca 23040

ccagccgcac cgcggcgtca tcgaaaccgt gtacctgcgc acgcccttct cggccggcaa 23100

cgccacaaca taaagaagca agcaacatca acaacagctg ccgccatggg ctccagtgag 23160

caggaactga aagccattgt caaagatctt ggttgtgggc catatttttt gggcacctat 23220

gacaagcgct ttccaggctt tgtttctcca cacaagctcg cctgcgccat agtcaatacg 23280

gccggtcgcg agactggggg cgtacactgg atggcctttg cctggaaccc gcactcaaaa 23340

acatgctacc tctttgagcc ctttggcttt tctgaccagc gactcaagca ggtttaccag 23400

tttgagtacg agtcactcct gcgccgtagc gccattgctt cttcccccga ccgctgtata 23460

acgctggaaa agtccaccca aagcgtacag gggcccaact cggccgcctg tggactattc 23520

tgctgcatgt ttctccacgc ctttgccaac tggccccaaa ctcccatgga tcacaacccc 23580

accatgaacc ttattaccgg ggtacccaac tccatgctca acagtcccca ggtacagccc 23640

accctgcgtc gcaaccagga acagctctac agcttcctgg agcgccactc gccctacttc 23700

cgcagccaca gtgcgcagat taggagcgcc acttcttttt gtcacttgaa aaacatgtaa 23760

aaataatgta ctagagacac tttcaataaa ggcaaatgct tttatttgta cactctcggg 23820

tgattattta cccccaccct tgccgtctgc gccgtttaaa aatcaaaggg gttctgccgc 23880

gcatcgctat gcgccactgg cagggacacg ttgcgatact ggtgtttagt gctccactta 23940

aactcaggca caaccatccg cggcagctcg gtgaagtttt cactccacag gctgcgcacc 24000

atcaccaacg cgtttagcag gtcgggcgcc gatatcttga agtcgcagtt ggggcctccg 24060

ccctgcgcgc gcgagttgcg atacacaggg ttgcagcact ggaacactat cagcgccggg 24120

tggtgcacgc tggccagcac gctcttgtcg gagatcagat ccgcgtccag gtcctccgcg 24180

ttgctcaggg cgaacggagt caactttggt agctgccttc ccaaaaaggg cgcgtgccca 24240

ggctttgagt tgcactcgca ccgtagtggc atcaaaaggt gaccgtgccc ggtctgggcg 24300

ttaggataca gcgcctgcat aaaagccttg atctgcttaa aagccacctg agcctttgcg 24360

ccttcagaga agaacatgcc gcaagacttg ccggaaaact gattggccgg acaggccgcg 24420

tcgtgcacgc agcaccttgc gtcggtgttg gagatctgca ccacatttcg gccccaccgg 24480

ttcttcacga tcttggcctt gctagactgc tccttcagcg cgcgctgccc gttttcgctc 24540

gtcacatcca tttcaatcac gtgctcctta tttatcataa tgcttccgtg tagacactta 24600

agctcgcctt cgatctcagc gcagcggtgc agccacaacg cgcagcccgt gggctcgtga 24660

tgcttgtagg tcacctctgc aaacgactgc aggtacgcct gcaggaatcg ccccatcatc 24720

gtcacaaagg tcttgttgct ggtgaaggtc agctgcaacc cgcggtgctc ctcgttcagc 24780

caggtcttgc atacggccgc cagagcttcc acttggtcag gcagtagttt gaagttcgcc 24840

tttagatcgt tatccacgtg gtacttgtcc atcagcgcgc gcgcagcctc catgcccttc 24900

tcccacgcag acacgatcgg cacactcagc gggttcatca ccgtaatttc actttccgct 24960

tcgctgggct cttcctcttc ctcttgcgtc cgcataccac gcgccactgg gtcgtcttca 25020

ttcagccgcc gcactgtgcg cttacctcct ttgccatgct tgattagcac cggtgggttg 25080

ctgaaaccca ccatttgtag cgccacatct tctctttctt cctcgctgtc cacgattacc 25140

tctggtgatg gcgggcgctc gggcttggga gaagggcgct tctttttctt cttgggcgca 25200

atggccaaat ccgccgccga ggtcgatggc cgcgggctgg gtgtgcgcgg caccagcgcg 25260

tcttgtgatg agtcttcctc gtcctcggac tcgatacgcc gcctcatccg cttttttggg 25320

ggcgcccggg gaggcggcgg cgacggggac ggggacgaca cgtcctccat ggttggggga 25380

cgtcgcgccg caccgcgtcc gcgctcgggg gtggtttcgc gctgctcctc ttcccgactg 25440

gccatttcct tctcctatag gcagaaaaag atcatggagt cagtcgagaa gaaggacagc 25500

ctaaccgccc cctctgagtt cgccaccacc gcctccaccg atgccgccaa cgcgcctacc 25560

accttccccg tcgaggcacc cccgcttgag gagggaggaag tgattatcga gcaggaccca 25620

ggttttgtaa gcgaagacga cgaggaccgc tcagtaccaa cagaggataa aaagcaagac 25680

caggacaacg cagaggcaaa cgaggaacaa gtcgggcggg gggacgaaag gcatggcgac 25740

tacctagatg tgggagacga cgtgctgttg aagcatctgc agcgccagtg cgccattatc 25800

tgcgacgcgt tgcaagagcg cagcgatgtg cccctcgcca tagcggatgt cagccttgcc 25860

tacgaacgcc acctattctc accgcgcgta ccccccaaac gccaagaaaa cggcacatgc 25920

gagcccaacc cgcgcctcaa cttctacccc gtatttgccg tgccagaggt gcttgccacc 25980

tatcacatct ttttccaaaa ctgcaagata cccctatcct gccgtgccaa ccgcagccga 26040

gcggacaagc agctggcctt gcggcagggc gctgtcatac ctgatatcgc ctcgctcaac 26100

gaagtgccaa aaatctttga gggtcttgga cgcgacgaga agcgcgcggc aaacgctctg 26160

caacaggaaa acagcgaaaa tgaaagtcac tctggagtgt tggtggaact cgaggtgac 26220

aacgcgcgcc tagccgtact aaaacgcagc atcgaggtca cccactttgc ctacccggca 26280

cttaacctac cccccaaggt catgagcaca gtcatgagtg agctgatcgt gcgccgtgcg 26340

cagcccctgg agagggatgc aaatttgcaa gaacaaacag aggagggcct acccgcagtt 26400

ggcgacgagc agctagcgcg ctggcttcaa acgcgcgagc ctgccgactt ggagggagcga 26460

cgcaaactaa tgatggccgc agtgctcgtt accgtggagc ttgagtgcat gcagcggttc 26520

tttgctgacc cggagatgca gcgcaagcta gaggaaacat tgcactacac ctttcgacag 26580

ggctacgtac gccaggcctg caagatctcc aacgtggagc tctgcaacct ggtctcctac 26640

cttggaattt tgcacgaaaa ccgccttggg caaaacgtgc ttcattccac gctcaagggc 26700

gaggcgcgcc gcgactacgt ccgcgactgc gtttacttat ttctatgcta cacctggcag 26760

acggccatgg gcgtttggca gcagtgcttg gaggagtgca acctcaagga gctgcagaaa 26820

ctgctaaagc aaaacttgaa ggacctatgg acggccttca acgagcgctc cgtggccgcg 26880

cacctggcgg acatcatttt ccccgaacgc ctgcttaaaa ccctgcaaca gggtctgcca 26940

gacttcacca gtcaaagcat gttgcagaac tttaggaact ttatcctaga gcgctcagga 27000

atcttgcccg ccacctgctg tgcacttcct agcgactttg tgcccattaa gtaccgcgaa 27060

tgccctccgc cgctttgggg ccactgctac cttctgcagc tagccaacta ccttgcctac 27120

cactctgaca taatggaaga cgtgagcggt gacggtctac tggagtgtca ctgtcgctgc 27180

aacctatgca ccccgcaccg ctccctggtt tgcaattcgc agctgcttaa cgaaagtcaa 27240

attatcggta cctttgagct gcagggtccc tcgcctgacg aaaagtccgc ggctccgggg 27300

ttgaaactca ctccggggct gtggacgtcg gcttaccttc gcaaatttgt acctgaggac 27360

taccacgccc acgagattag gttctacgaa gaccaatccc gcccgcctaa tgcggagctt 27420

accgcctgcg tcattaccca gggccacatt cttggccaat tgcaagccat caacaaagcc 27480

cgccaagagt ttctgctacg aaagggacgg ggggtttact tggaccccca gtccggcgag 27540

gagctcaacc caatcccccc gccgccgcag ccctatcagc agcagccgcg ggcccttgct 27600

tcccaggatg gcacccaaaa agaagctgca gctgccgccg cccaccacgg acgaggagga 27660

atactgggac agtcaggcag aggaggtttt ggacgaggag gagggagca tgatggaaga 27720

ctggggagagc ctagacgagg aagcttccga ggtcgaagag gtgtcagacg aaacaccgtc 27780

accctcggtc gcattcccct cgccggcgcc ccagaaatcg gcaaccggtt ccagcatggc 27840

tacaacctcc gctcctcagg cgccgccggc actgcccgtt cgccgaccca accgtagatg 27900

ggacaccact ggaaccaggg ccggtaagtc caagcagccg ccgccgttag cccaagagca 27960

acaacagcgc caaggctacc gctcatggcg cgggcacaag aacgccatag ttgcttgctt 28020

gcaagactgt gggggcaaca tctccttcgc ccgccgcttt cttctctacc atcacggcgt 28080

ggccttcccc cgtaacatcc tgcattacta ccgtcatctc tacagcccat actgcaccgg 28140

cggcagcggc agcaacagca gcggccacac agaagcaaag gcgaccggat agcaagactc 28200

tgacaaagcc caagaaatcc acagcggcgg cagcagcagg aggagggagcg ctgcgtctgg 28260

cgcccaacga acccgtatcg acccgcgagc ttagaaacag gatttttccc actctgtatg 28320

ctatatttca acagagcagg ggccaagaac aagagctgaa aataaaaaac aggtctctgc 28380

gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga tcagcttcgg cgcacgctgg 28440

aagacgcgga ggctctcttc agtaaatact gcgcgctgac tcttaaggac tagtttcgcg 28500

ccctttctca aatttaagcg cgaaaactac gtcatctcca gcggccacac ccggcgccag 28560

cacctgttgt cagcgccatt atgagcaagg aaattcccac gccctacatg tggagttacc 28620

agccacaaat gggacttgcg gctggagctg cccaagacta ctcaacccga ataaactaca 28680

tgagcgcggg accccacatg atatcccggg tcaacggaat acgcgcccac cgaaaccgaa 28740

ttctcctgga acaggcggct attaccacca cacctcgtaa taaccttaat ccccgtagtt 28800

ggcccgctgc cctggtgtac caggaaagtc ccgctcccac cactgtggta cttcccagag 28860

acgcccaggc cgaagttcag atgactaact caggggcgca gcttgcgggc ggctttcgtc 28920

acagggtgcg gtcgcccggg cagggtataa ctcacctgac aatcagaggg cgaggtattc 28980

agctcaacga cgagtcggtg agctcctcgc ttggtctccg tccggacggg acatttcaga 29040

tcggcggcgc cggccgctct tcattcacgc ctcgtcaggc aatcctaact ctgcagacct 29100

cgtcctctga gccgcgctct ggaggcattg gaactctgca atttattgag gagtttgtgc 29160

catcggtcta ctttaacccc ttctcgggac ctcccggcca ctatccggat caatttattc 29220

ctaactttga cgcggtaaag gactcggcgg acggctacga ctgaatgtta agtggagagg 29280

cagagcaact gcgcctgaaa cacctggtcc actngtcgccg ccacaagtgc tttgcccgcg 29340

actccggtga gttttgctac tttgaattgc ccgaggatca tatcgagggc ccggcgcacg 29400

gcgtccggct taccgcccag ggagagcttg cccgtagcct gattcgggag tttacccagc 29460

gccccctgct agttgagcgg gacaggggac cctgtgttct cactgtgatt tgcaactgtc 29520

ctaaccctgg attacatcaa gatcctctag ttaatgtcag gtcgcctaag tcgattaact 29580

agagtacccg gggatcttat tccctttaac taataaaaaa aaataataaa gcatcactta 29640

cttaaaatca gttagcaaat ttctgtccag tttattcagc agcacctcct tgccctcctc 29700

ccagctctgg tattgcagct tcctcctggc tgcaaacttt ctccacaatc taaatggaat 29760

gtcagtttcc tcctgttcct gtccatccgc acccactatc ttcatgttgt tgcagatgaa 29820

gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat ccatatgaca cggaaaccgg 29880

tcctccaact gtgccttttc ttactcctcc ctttgtatcc cccaatgggt ttcaagagag 29940

tccccctggg gtactctctt tgcgcctatc cgaacctcta gttacctcca atggcatgct 30000

tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc ggcaacctta cctcccaaaa 30060

tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca aacataaacc tggaaatatc 30120

tgcacccctc acagttacct cagaagccct aactgtggct gccgccgcac ctctaatggt 30180

cgcgggcaac acactcacca tgcaatcaca ggccccgcta accgtgcacg actccaaact 30240

tagcattgcc acccaaggac ccctcacagt gtcagaagga aagctagccc tgcaaacatc 30300

aggccccctc accaccaccg atagcagtac ccttactatc actgcctcac cccctctaac 30360

tactgccact ggtagcttgg gcattgactt gaaagagccc atttatacac aaaatggaaa 30420

actaggacta aagtacgggg ctcctttgca tgtaacagac gacctaaaca ctttgaccgt 30480

agcaactggt ccaggtgtga ctattaataa tacttccttg caaactaaag ttactggagc 30540

cttgggtttt gattcacaag gcaatatgca acttaatgta gcaggaggac taaggattga 30600

ttctcaaaac agacgcctta tacttgatgt tagttatccg tttgatgctc aaaaccaact 30660

aaatctaaga ctaggacagg gccctctttt tataaactca gcccacaact tggatattaa 30720

ctacaacaaa ggcctttact tgtttacagc ttcaaacaat tccaaaaagc ttgaggttaa 30780

cctaagcact gccaaggggt tgatgtttga cgctacagcc atagccatta atgcaggaga 30840

tgggcttgaa tttggttcac ctaatgcacc aaacacaaat cccctcaaaa caaaaattgg 30900

ccatggccta gaatttgatt caaacaaggc tatggttcct aaactaggaa ctggccttag 30960

ttttgacagc acaggtgcca ttacagtagg aaacaaaaat aatgataagc taactttgtg 31020

gaccggaata aaccctccac ctaactgtca aattgtggaa aacactaata caaatgatgg 31080

caaacttact ttagtattag taaaaaatgg agggcttgtt aatggctacg tgtctctagt 31140

tggtgtatca gacactgtga accaaatgtt cacacaaaag acagcaaaca tccaattaag 31200

attatatttt gactcttctg gaaatctatt aactgaggaa tcagacttaa aaattccact 31260

taaaaataaa tcttctacag cgaccagtga aactgtagcc agcagcaaag cctttatgcc 31320

aagtactaca gcttatccct tcaacaccac tactagggat agtgaaaact acattcatgg 31380

aatatgttac tacatgacta gttatgatag aagtctattt cccttgaaca tttctataat 31440

gctaaacagc cgtatgattt cttccaatgt tgcctatgcc atacaatttg aatggaatct 31500

aaatgcaagt gaatctccag aaagcaacat agctacgctg accacatccc cctttttctt 31560

ttcttacatt acagaagacg acaactaaag aatcgtttgt gttatgtttc aacgtgttta 31620

tttttcaatt gcagaaaatt tcaagtcatt tttcattcag tagtatagcc ccaccaccac 31680

atagcttata cagatcaccg taccttaatc aaactcacag aaccctagta ttcaacctgc 31740

cacctccctc ccaacacaca gagtacacag tcctttctcc ccggctggcc ttaaaaagca 31800

tcatatcatg ggtaacagac atattcttag gtgttatatt cccacggtt tcctgtcgag 31860

ccaaacgctc atcagtgata ttaataaact ccccggggcag ctcacttaag ttcatgtcgc 31920

tgtccagctg ctgagccaca ggctgctgtc caacttgcgg ttgcttaacg ggcggcgaag 31980

gagaagtcca cgcctacatg ggggtagagt cataatcgtg catcaggata gggcggtggt 32040

gctgcagcag cgcgcgaata aactgctgcc gccgccgctc cgtcctgcag gaatacaaca 32100

tggcagtggt ctcctcagcg atgattcgca ccgcccgcag cataaggcgc cttgtcctcc 32160

gggcacagca gcgcaccctg atctcactta aatcagcaca gtaactgcag cacagcacca 32220

caatattgtt caaaatccca cagtgcaagg cgctgtatcc aaagctcatg gcggggacca 32280

cagaacccac gtggccatca taccacaagc gcaggtagat taagtggcga cccctcataa 32340

acacgctgga cataaacatt acctcttttg gcatgttgta attcaccacc tcccggtacc 32400

atataaacct ctgattaaac atggcgccat ccaccaccat cctaaaccag ctggccaaaa 32460

cctgcccgcc ggctatacac tgcagggaac cgggactgga acaatgacag tggagagccc 32520

aggactcgta accatggatc atcatgctcg tcatgatatc aatgttggca caacacaggc 32580

acacgtgcat acacttcctc aggattacaa gctcctcccg cgttagaacc atatcccagg 32640

gaacaaccca ttcctgaatc agcgtaaatc cccacactgca gggaagacct cgcacgtaac 32700

tcacgttgtg cattgtcaaa gtgttacatt cgggcagcag cggatgatcc tccagtatgg 32760

tagcgcgggt ttctgtctca aaaggaggta gacgatccct actgtacgga gtgcgccgag 32820

acaaccgaga tcgtgttggt cgtagtgtca tgccaaatgg aacgccggac gtagtcatat 32880

ttcctgaagc aaaaccaggt gcgggcgtga caaacagatc tgcgtctccg gtctcgccgc 32940

ttagatcgct ctgtgtagta gttgtagtat atccactctc tcaaagcatc caggcgcccc 33000

ctggcttcgg gttctatgta aactccttca tgcgccgctg ccctgataac atccaccacc 33060

gcagaataag ccacacccag ccaacctaca cattcgttct gcgagtcaca cacgggagga 33120

gcgggaagag ctggaagaac catgtttttt tttttattcc aaaagattat ccaaaacctc 33180

aaaatgaaga tctattaagt gaacgcgctc ccctccggtg gcgtggtcaa actctacagc 33240

caaagaacag ataatggcat ttgtaagatg ttgcacaatg gcttccaaaa ggcaaacggc 33300

cctcacgtcc aagtggacgt aaaggctaaa cccttcagg tgaatctcct ctataaacat 33360

tccagcacct tcaaccatgc ccaaataatt ctcatctcgc caccttctca atatatctct 33420

aagcaaatcc cgaatattaa gtccggccat tgtaaaaatc tgctccagag cgccctccac 33480

cttcagcctc aagcagcgaa tcatgattgc aaaaattcag gttcctcaca gacctgtata 33540

agattcaaaa gcggaacatt aacaaaaata ccgcgatccc gtaggtccct tcgcagggcc 33600

agctgaacat aatcgtgcag gtctgcacgg accagcgcgg ccacttcccc gccaggaacc 33660

atgacaaaag aacccacact gattatgaca cgcatactcg gagctatgct aaccagcgta 33720

gccccgatgt aagcttgttg catgggcggc gatataaaat gcaaggtgct gctcaaaaaa 33780

tcaggcaaag cctcgcgcaa aaaagaaagc acatcgtagt catgctcatg cagataaagg 33840

caggtaagct ccggaaccac cacagaaaaa gacaccattt ttctctcaaa catgtctgcg 33900

ggtttctgca taaacacaaa ataaaataac aaaaaaacat ttaaacatta gaagcctgtc 33960

ttacaacagg aaaaacaacc cttataagca taagacggac tacggccatg ccggcgtgac 34020

cgtaaaaaaa ctggtcaccg tgattaaaaa gcaccaccga cagctcctcg gtcatgtccg 34080

gagtcataat gtaagactcg gtaaacacat caggttgatt cacatcggtc agtgctaaaa 34140

agcgaccgaa atagcccggg ggaatacata cccgcaggcg tagagacaac attacagccc 34200

ccataggagg tataacaaaa ttaataggag agaaaaacac ataaacacct gaaaaaccct 34260

cctgcctagg caaaatagca ccctcccgct ccagaacaac atacagcgct tccacagcgg 34320

cagccataac agtcagcctt accagtaaaa aagaaaacct attaaaaaaa caccactcga 34380

cacggcacca gctcaatcag tcacagtgta aaaaagggcc aagtgcagag cgagtatata 34440

taggactaaa aaatgacgta acggttaaag tccacaaaaa acacccagaa aaccgcacgc 34500

gaacctacgc ccagaaacga aagccaaaaa acccacaact tcctcaaatc gtcacttccg 34560

ttttcccacg ttacgtcact tcccatttta agaaaactac aattcccaac acatacaagt 34620

tactccgccc taaaacctac gtcacccgcc ccgttcccac gccccgcgcc acgtcacaaa 34680

ctccaccccc tcattatcat attggcttca atccaaaata aggtatatta ttgatgatg 34739

<210> 24

<211> 37666

<212> DNA

<213> Artificial sequence

<220>

<223> plasmid vector #2

<400> 24

ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag 180

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa 780

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt 1020

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc 1200

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320

ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tactgggcta 1440

tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500

ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560

cgccctctgg taaggttggg aagccctgca aagtaaactg gatggctttc ttgccgccaa 1620

ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860

aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc 2040

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg 2460

acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520

gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640

aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt 2880

aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940

atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000

tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060

atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120

tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180

aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240

gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 3300

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta 3600

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccatg 3720

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780

actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca 3840

gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt cgacgagctc 3900

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa 3960

gacaccggga ccgatccagc ctccgatttg ccaccatgtt tgtgttcctg gtgctgctgc 4020

cactggtgtc cagccagtgt gtgaacctga ccaccaggac ccaacttcct cctgcctaca 4080

ccaactcctt caccagggga gtctactacc ctgacaaggt gttcaggtcc tctgtgctgc 4140

acagcaccca ggacctgttc ctgccattct tcagcaatgt gacctggttc catgccatcc 4200

atgtgtctgg caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg 4260

gagtctactt tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca 4320

ccctggacag caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta 4380

aggtgtgtga gttccagttc tgtaatgacc cattcctggg agtctactac cacaagaaca 4440

acaagtcctg gatggagtct gagttcaggg tctactcctc tgccaacaac tgtacctttg 4500

aatatgtgag ccaaccattc ctgatggact tggagggcaa gcagggcaac ttcaagaacc 4560

tgagggagtt tgtgttcaag aacattgatg gctacttcaa gatttacagc aaacacacac 4620

caatcaacct ggtgagggac ctgccacagg gcttctctgc cttggaacca ctggtggacc 4680

tgccaattgg catcaacatc accaggttcc agaccctgct ggctctgcac aggtcctacc 4740

tgacacctgg agactcctcc tctggctgga cagcaggagc agcagcctac tatgtgggct 4800

acctccaacc aaggaccttc ctgctgaaat acaatgagaa tggcaccatc acagatgctg 4860

tggactgtgc cctggaccca ctgtctgaga ccaagtgtac cctgaaatcc ttcacagtgg 4920

agaagggcat ctaccagacc agcaacttca gggtccaacc aacagagagc attgtgaggt 4980

ttccaaacat caccaacctg tgtccatttg gagaggtgtt caatgccacc aggtttgcct 5040

ctgtctatgc ctggaacagg aagaggatta gcaactgtgt ggctgactac tctgtgctct 5100

acaactctgc ctccttcagc accttcaagt gttatggagt gagcccaacc aaactgaatg 5160

acctgtgttt caccaatgtc tatgctgact cctttgtgat taggggagat gaggtgagac 5220

agattgcccc tggacaaaca ggcaagattg ctgactacaa ctacaaactg cctgatgact 5280

tcacaggctg tgtgattgcc tggaacagca acaacctgga cagcaaggtg ggaggcaact 5340

acaactacct ctacagactg ttcaggaaga gcaacctgaa accatttgag agggacatca 5400

gcacagagat ttaccaggct ggcagcacac catgtaatgg agtggagggc ttcaactgtt 5460

actttccact ccaatcctat ggcttccaac caaccaatgg agtgggctac caaccataca 5520

gggtggtggt gctgtccttt gaactgctcc atgcccctgc cacagtgtgt ggaccaaaga 5580

agagcaccaa cctggtgaag aacaagtgtg tgaacttcaa cttcaatgga ctgacaggca 5640

caggagtgct gacagagagc aacaagaagt tcctgccatt ccaacagttt ggcagggaca 5700

ttgctgacac cacagatgct gtgagggacc cacagacctt ggagattctg gacatcacac 5760

catgttcctt tggagagtg tctgtgatta cacctggcac caacaccagc aaccaggtgg 5820

ctgtgctcta ccaggatgtg aactgtactg aggtgcctgt ggctatccat gctgaccaac 5880

ttacaccaac ctggagggtc tacagcacag gcagcaatgt gttccagacc agggctggct 5940

gtctgattgg agcagagcat gtgaacaact cctatgagtg tgacatccca attggagcag 6000

gcatctgtgc ctcctaccag acccagacca tcctcaggtc tgtggcaagc cagagcatca 6060

ttgcctacac aatgagtctg ggagcagaga actctgtggc ttacagcaac aacagcattg 6120

ccatcccaac caacttcacc atctctgtga cccacagagat tctgcctgtg agtatgacca 6180

agacctctgt ggactgtaca atgtatatct gtggagacag cacagagtgt agcaacctgc 6240

tgctccaata tggctccttc tgtacccaac ttaacagggc tctgacaggc attgctgtgg 6300

aacaggacaa gaacacccag gaggtgtttg cccaggtgaa gcagatttac aagacacctc 6360

caatcaagga ctttggaggc ttcaacttca gccagattct gcctgaccca agcaagccaa 6420

gcaagaggtc cttcattgag gacctgctgt tcaacaaggt gaccctggct gatgctggct 6480

tcatcaagca atatggagac tgtctgggag acattgctgc cagggacctg atttgtgccc 6540

agaagttcaa tggactgaca gtgctgcctc cactgctgac agatgagatg attgcccaat 6600

acacctctgc cctgctggct ggcaccatca cctctggctg gacctttgga gcaggagcag 6660

ccctccaaat cccatttgct atgcagatgg cttacaggtt caatggcatt ggagtgaccc 6720

agaatgtgct ctatgagaac cagaaactga ttgccaacca gttcaactct gccattggca 6780

agattcagga ctccctgtcc agcacagcct ctgccctggg caaactccaa gatgtggtga 6840

accagaatgc ccaggctctg aacaccctgg tgaagcaact ttccagcaac tttggagcca 6900

tctcctctgt gctgaatgac atcctgagca gactggacaa ggtggaggct gaggtccaga 6960

ttgacagact gattacaggc agactccaat ccctccaaac ctatgtgacc caacaactta 7020

tcagggctgc tgagattagg gcatctgcca acctggctgc caccaagatg agtgagtgtg 7080

tgctgggaca aagcaagagg gtggacttct gtggcaaggg ctaccacctg atgagttttc 7140

cacagtctgc ccctcatgga gtggtgttcc tgcatgtgac ctatgtgcct gcccaggaga 7200

agaacttcac cacagcccct gccatctgcc atgatggcaa ggctcacttt ccaagggagg 7260

gagtgtttgt gagcaatggc acccactggt ttgtgaccca gaggaacttc tatgaaccac 7320

agattatcac cacagacaac acctttgtgt ctggcaactg tgatgtggtg attggcattg 7380

tgaacaacac agtctatgac ccactccaac ctgaactgga ctccttcaag gaggaactgg 7440

acaaatactt caagaaccac accagccctg atgtggacct gggagacatc tctggcatca 7500

atgcctctgt ggtgaacatc cagaaggaga ttgacagact gaatgaggtg gctaagaacc 7560

tgaatgagtc cctgattgac ctccaagaac tgggcaaata tgaacaatac atcaagtggc 7620

catgaaaatt gacataatc agccatacca catttgtaga ggttttactt gctttaaaaa 7680

acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact 7740

tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 7800

aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttaac 7860

gcggatctgg gcgtggttaa gggtgggaaa gaatatataa ggtgggggtc ttatgtagtt 7920

ttgtatctgt tttgcagcag ccgccgccgc catgagcacc aactcgtttg atggaagcat 7980

tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 8040

gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 8100

gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 8160

caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 8220

ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 8280

gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 8340

cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 8400

ttggatttgg atcaagcaag tgtcttgctg tctttattta ggggttttgc gcgcgcggta 8460

ggcccgggac cagcggtctc ggtcgttgag ggtcctgtgt attttttcca ggacgtggta 8520

aaggtgactc tggatgttca gatacatggg cataagcccg tctctggggt ggaggtagca 8580

ccactgcaga gcttcatgct gcggggtggt gttgtagatg atccagtcgt agcaggagcg 8640

ctgggcgtgg tgcctaaaaa tgtctttcag tagcaagctg attgccaggg gcaggccctt 8700

ggtgtaagtg tttacaaagc ggttaagctg ggatgggtgc atacgtgggg atatgagatg 8760

catcttggac tgtattttta ggttggctat gttcccagcc atatccctcc ggggattcat 8820

gttgtgcaga accaccagca cagtgtatcc ggtgcacttg ggaaatttgt catgtagctt 8880

agaaggaaat gcgtggaaga acttggagac gcccttgtga cctccaagat tttccatgca 8940

ttcgtccata atgatggcaa tgggcccacg ggcggcggcc tgggcgaaga tatttctggg 9000

atcactaacg tcatagttgt gttccaggat gagatcgtca taggccattt ttacaaagcg 9060

cgggcggagg gtgccagact gcggtataat ggttccatcc ggcccagggg cgtagttacc 9120

ctcacagatt tgcatttccc acgctttgag ttcagatggg gggatcatgt ctacctgcgg 9180

ggcgatgaag aaaacggttt ccggggtagg ggagatcagc tgggaagaaa gcaggttcct 9240

gagcagctgc gacttaccgc agccggtggg cccgtaaatc acacctatta ccggctgcaa 9300

ctggtagtta agagagctgc agctgccgtc atccctgagc aggggggcca cttcgttaag 9360

catgtccctg actcgcatgt tttccctgac caaatccgcc agaaggcgct cgccgcccag 9420

cgatagcagt tcttgcaagg aagcaaagtt tttcaacggt ttgagaccgt ccgccgtagg 9480

catgcttttg agcgtttgac caagcagttc caggcggtcc cacagctcgg tcacctgctc 9540

tacggcatct cgatccagca tatctcctcg tttcgcgggt tggggcggct ttcgctgtac 9600

ggcagtagtc ggtgctcgtc cagacggggcc agggtcatgt ctttccacgg gcgcagggtc 9660

ctcgtcagcg tagtctgggt cacggtgaag gggtgcgctc cgggctgcgc gctggccagg 9720

gtgcgcttga ggctggtcct gctggtgctg aagcgctgcc ggtcttcgcc ctgcgcgtcg 9780

gccaggtagc atttgaccat ggtgtcatag tccagcccct ccgcggcgtg gcccttggcg 9840

cgcagcttgc ccttggagga ggcgccgcac gaggggcagt gcagactttt gagggcgtag 9900

agcttgggcg cgagaaatac cgattccggg gagtaggcat ccgcgccgca ggccccgcag 9960

acggtctcgc attccacgag ccaggtgagc tctggccgtt cggggtcaaa aaccaggttt 10020

cccccatgct ttttgatgcg tttcttacct ctggtttcca tgagccggtg tccacgctcg 10080

gtgacgaaaa ggctgtccgt gtccccgtat acagacttga gaggcctgtc ctcgagcggt 10140

gttccgcggt cctcctcgta tagaaactcg gaccactctg agacaaaggc tcgcgtccag 10200

gccagcacga aggaggctaa gtgggagggg tagcggtcgt tgtccactag ggggtccact 10260

cgctccaggg tgtgaagaca catgtcgccc tcttcggcat caaggaaggt gattggtttg 10320

taggtgtagg ccacgtgacc gggtgttcct gaaggggggc tataaaaggg ggtgggggcg 10380

cgttcgtcct cactctcttc cgcatcgctg tctgcgaggg ccagctgttg gggtgagtac 10440

tccctctgaa aagcgggcat gacttctgcg ctaagattgt cagtttccaa aaacgaggag 10500

gatttgatat tcacctggcc cgcggtgatg cctttgagg tggccgcatc catctggtca 10560

gaaaagacaa tctttttgtt gtcaagcttg gtggcaaacg acccgtagag ggcgttggac 10620

agcaacttgg cgatggagcg cagggtttgg tttttgtcgc gatcggcgcg ctccttggcc 10680

gcgatgttta gctgcacgta ttcgcgcgca acgcaccgcc attcgggaaa gacggtggtg 10740

cgctcgtcgg gcaccaggtg cacgcgccaa ccgcggttgt gcagggtgac aaggtcaacg 10800

ctggtggcta cctctccgcg taggcgctcg ttggtccagc agaggcggcc gcccttgcgc 10860

gagcagaatg gcggtagggg gtctagctgc gtctcgtccg gggggtctgc gtccacggta 10920

aagaccccgg gcagcaggcg cgcgtcgaag tagtctatct tgcatccttg caagtctagc 10980

gcctgctgcc atgcgcgggc ggcaagcgcg cgctcgtatg ggttgagtgg gggaccccat 11040

ggcatggggt gggtgagcgc ggaggcgtac atgccgcaaa tgtcgtaaac gtagaggggc 11100

tctctgagta ttccaagata tgtagggtag catcttccac cgcggatgct ggcgcgcacg 11160

taatcgtata gttcgtgcga gggagcgagg aggtcgggac cgaggttgct acgggcgggc 11220

tgctctgctc ggaagactat ctgcctgaag atggcatgtg agttggatga tatggttgga 11280

cgctggaaga cgttgaagct ggcgtctgtg agacctaccg cgtcacgcac gaaggaggcg 11340

taggagtcgc gcagcttgtt gaccagctcg gcggtgacct gcacgtctag ggcgcagtag 11400

tccagggttt ccttgatgat gtcatactta tcctgtccct tttttttcca cagctcgcgg 11460

ttgaggacaa actcttcgcg gtctttccag tactcttgga tcggaaaccc gtcggcctcc 11520

gaacggtaag agcctagcat gtagaactgg ttgacggcct ggtaggcgca gcatcccttt 11580

tctacgggta gcgcgtatgc ctgcgcggcc ttccggagcg aggtgtgggt gagcgcaaag 11640

gtgtccctga ccatgacttt gaggtactgg tatttgaagt cagtgtcgtc gcatccgccc 11700

tgctcccaga gcaaaaagtc cgtgcgcttt ttggaacgcg gatttggcag ggcgaaggtg 11760

acatcgttga agagtatctt tcccgcgcga ggcataaagt tgcgtgtgat gcggaagggt 11820

cccggcacct cggaacggtt gttaattacc tgggcggcga gcacgatctc gtcaaagccg 11880

ttgatgttgt ggcccacaat gtaaagttcc aagaagcgcg ggatgccctt gatggaaggc 11940

aattttttaa gttcctcgta ggtgagctct tcaggggagc tgagcccgtg ctctgaaagg 12000

gcccagtctg caagatgagg gttggaagcg acgaatgagc tccacaggtc acgggccatt 12060

agcatttgca ggtggtcgcg aaaggtccta aactggcgac ctatggccat tttttctggg 12120

gtgatgcagt agaaggtaag cgggtcttgt tcccagcggt cccatccaag gttcgcggct 12180

aggtctcgcg cggcagtcac tagaggctca tctccgccga acttcatgac cagcatgaag 12240

ggcacgagct gcttcccaaa ggcccccatc caagtatagg tctctacatc gtaggtgaca 12300

aagagacgct cggtgcgagg atgcgagccg atcgggaaga actggatctc ccgccaccaa 12360

ttggagggagt ggctattgat gtggtgaaag tagaagtccc tgcgacgggc cgaacactcg 12420

tgctggcttt tgtaaaaacg tgcgcagtac tggcagcggt gcacgggctg tacatcctgc 12480

acgaggttga cctgacgacc gcgcacaagg aagcagagtg ggaatttgag cccctcgcct 12540

ggcgggtttg gctggtggtc ttctacttcg gctgcttgtc cttgaccgtc tggctgctcg 12600

aggggagtta cggtggatcg gaccaccacg ccgcgcgagc ccaaagtcca gatgtccgcg 12660

cgcggcggtc ggagcttgat gacaacatcg cgcagatggg agctgtccat ggtctggagc 12720

tcccgcggcg tcaggtcagg cgggagctcc tgcaggttta cctcgcatag acgggtcagg 12780

gcgcgggcta gatccaggtg atacctaatt tccaggggct ggttggtggc ggcgtcgatg 12840

gcttgcaaga ggccgcatcc ccgcggcgcg actacggtac cgcgcggcgg gcggtgggcc 12900

gcggggggtgt ccttggatga tgcatctaaa agcggtgacg cgggcgagcc cccggaggta 12960

gggggggctc cggacccgcc gggagagggg gcaggggcac gtcggcgccg cgcgcgggca 13020

ggagctggtg ctgcgcgcgt aggttgctgg cgaacgcgac gacgcggcgg ttgatctcct 13080

gaatctggcg cctctgcgtg aagacgacgg gcccggtgag cttgaacctg aaagagagtt 13140

cgacagaatc aatttcggtg tcgttgacgg cggcctggcg caaaatctcc tgcacgtctc 13200

ctgagttgtc ttgataggcg atctcggcca tgaactgctc gatctcttcc tcctggagat 13260

ctccgcgtcc ggctcgctcc acggtggcgg cgaggtcgtt ggaaatgcgg gccatgagct 13320

gcgagaaggc gttgaggcct ccctcgttcc agacgcggct gtagaccacg cccccttcgg 13380

catcgcgggc gcgcatgacc acctgcgcga gattgagctc cacgtgccgg gcgaagacgg 13440

cgtagtttcg caggcgctga aagaggtagt tgaggtggt ggcggtgtgt tctgccacga 13500

agaagtacat aacccagcgt cgcaacgtgg attcgttgat atcccccaag gcctcaaggc 13560

gctccatggc ctcgtagaag tccacggcga agttgaaaaa ctgggagttg cgcgccgaca 13620

cggttaactc ctcctccaga agacggatga gctcggcgac agtgtcgcgc acctcgcgct 13680

caaaggctac aggggcctct tcttcttctt caatctcctc ttccataagg gcctcccctt 13740

cttcttcttc tggcggcggt gggggagggg ggacacggcg gcgacgacgg cgcaccggga 13800

ggcggtcgac aaagcgctcg atcatctccc cgcggcgacg gcgcatggtc tcggtgacgg 13860

cgcggccgtt ctcgcggggg cgcagttgga agacgccgcc cgtcatgtcc cggttatggg 13920

ttggcggggg gctgccatgc ggcagggata cggcgctaac gatgcatctc aacaattgtt 13980

gtgtaggtac tccgccgccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc 14040

tctcgagaaa ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg 14100

gcagcgggcg gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt 14160

aggcggtctt gagacggcgg atggtcgaca gaagcaccat gtccttgggt ccggcctgct 14220

gaatgcgcag gcggtcggcc atgccccagg cttcgttttg acatcggcgc aggtctttgt 14280

agtagtcttg catgagcctt tctaccggca cttcttcttc tccttcctct tgtcctgcat 14340

ctcttgcatc tatcgctgcg gcggcggcgg agtttggccg taggtggcgc cctcttcctc 14400

ccatgcgtgt gaccccgaag cccctcatcg gctgaagcag ggctaggtcg gcgacaacgc 14460

gctcggctaa tatggcctgc tgcacctgcg tgagggtaga ctggaagtca tccatgtcca 14520

caaagcggtg gtatgcgccc gtgttgatgg tgtaagtgca gttggccata acggaccagt 14580

taacggtctg gtgacccggc tgcgagagct cggtgtacct gagacgcgag taagccctcg 14640

agtcaaatac gtagtcgttg caagtccgca ccaggtactg gtatcccacc aaaaagtgcg 14700

gcggcggctg gcggtagagg ggccagcgta gggtggccgg ggctccgggg gcgagatctt 14760

ccaacataag gcgatgatat ccgtagatgt acctggacat ccaggtgatg ccggcggcgg 14820

tggtggaggc gcgcggaaag tcgcggacgc ggttccagat gttgcgcagc ggcaaaaagt 14880

gctccatggt cgggacgctc tggccggtca ggcgcgcgca atcgttgacg ctctagcgtg 14940

caaaaggaga gcctgtaagc gggcactctt ccgtggtctg gtggataaat tcgcaagggt 15000

atcatggcgg acgaccgggg ttcgagcccc gtatccggcc gtccgccgtg atccatgcgg 15060

ttaccgcccg cgtgtcgaac ccaggtgtgc gacgtcagac aacgggggag tgctcctttt 15120

ggcttccttc caggcgcggc ggctgctgcg ctagcttttt tggccactgg ccgcgcgcag 15180

cgtaagcggt taggctggaa agcgaaagca ttaagtggct cgctccctgt agccggaggg 15240

ttattttcca agggttgagt cgcgggaccc ccggttcgag tctcggaccg gccggactgc 15300

ggcgaacggg ggtttgcctc cccgtcatgc aagaccccgc ttgcaaattc ctccggaaac 15360

agggacgagc cccttttttg cttttcccag atgcatccgg tgctgcggca gatgcgcccc 15420

cctcctcagc agcggcaaga gcaagagcag cggcagacat gcagggcacc ctcccctcct 15480

cctaccgcgt caggaggggc gacatccgcg gttgacgcgg cagcagatgg tgattacgaa 15540

cccccgcggc gccgggcccg gcactacctg gacttggagg agggcgaggg cctggcgcgg 15600

ctaggagcgc cctctcctga gcggcaccca agggtgcagc tgaagcgtga tacgcgtgag 15660

gcgtacgtgc cgcggcagaa cctgtttcgc gaccgcgagg gagaggagcc cgaggagatg 15720

cgggatcgaa agttccacgc agggcgcgag ctgcggcatg gcctgaatcg cgagcggttg 15780

ctgcgcgagg aggactttga gcccgacgcg cgaaccggga ttagtcccgc gcgcgcacac 15840

gtggcggccg ccgacctggt aaccgcatac gagcagacgg tgaaccagga gattaacttt 15900

caaaaaagct ttaacaacca cgtgcgtacg cttgtggcgc gcgaggaggt ggctatagga 15960

ctgatgcatc tgtgggactt tgtaagcgcg ctggagcaaa acccaaatag caagccgctc 16020

atggcgcagc tgttccttat agtgcagcac agcagggaca acgaggcatt cagggatgcg 16080

ctgctaaaca tagtagagcc cgagggccgc tggctgctcg atttgataaa catcctgcag 16140

agcatagtgg tgcaggagcg cagcttgagc ctggctgaca aggtggccgc catcaactat 16200

tccatgctta gcctgggcaa gttttacgcc cgcaagatat accatacccc ttacgttccc 16260

atagacaagg aggtaaagat cgaggggttc tacatgcgca tggcgctgaa ggtgcttacc 16320

ttgagcgacg acctgggcgt ttatcgcaac gagcgcatcc acaaggccgt gagcgtgagc 16380

cggcggcgcg agctcagcga ccgcgagctg atgcacagcc tgcaaagggc cctggctggc 16440

acgggcagcg gcgatagaga ggccgagtcc tactttgacg cgggcgctga cctgcgctgg 16500

gccccaagcc gacgcgccct ggaggcagct ggggccggac ctgggctggc ggtggcaccc 16560

gcgcgcgctg gcaacgtcgg cggcgtggag gaatatgacg aggacgatga gtacgagcca 16620

gaggacggcg agtactaagc ggtgatgttt ctgatcagat gatgcaagac gcaacggacc 16680

cggcggtgcg ggcggcgctg cagagccagc cgtccggcct taactccacg gacgactggc 16740

gccaggtcat ggaccgcatc atgtcgctga ctgcgcgcaa tcctgacgcg ttccggcagc 16800

agccgcaggc caaccggctc tccgcaattc tggaagcggt ggtcccggcg cgcgcaaacc 16860

ccacgcacga gaaggtgctg gcgatcgtaa acgcgctggc cgaaaacagg gccatccggc 16920

ccgacgaggc cggcctggtc tacgacgcgc tgcttcagcg cgtggctcgt tacaacagcg 16980

gcaacgtgca gaccaacctg gaccggctgg tgggggatgt gcgcgaggcc gtggcgcagc 17040

gtgagcgcgc gcagcagcag ggcaacctgg gctccatggt tgcactaaac gccttcctga 17100

gtacacagcc cgccaacgtg ccgcggggac aggaggacta caccaacttt gtgagcgcac 17160

tgcggctaat ggtgactgag acaccgcaaa gtgaggtgta ccagtctggg ccagactatt 17220

ttttccagac cagtagacaa ggcctgcaga ccgtaaacct gagccaggct ttcaaaaact 17280

tgcaggggct gtggggggtg cgggctccca caggcgaccg cgcgaccgtg tctagcttgc 17340

tgacgcccaa ctcgcgcctg ttgctgctgc taatagcgcc cttcacggac agtggcagcg 17400

tgtcccggga cacataccta ggtcacttgc tgacactgta ccgcgaggcc ataggtcagg 17460

cgcatgtgga cgagcatact ttccaggaga ttacaagtgt cagccgcgcg ctggggcagg 17520

aggacacggg cagcctggag gcaaccctaa actacctgct gaccaaccgg cggcagaaga 17580

tcccctcgtt gcacagttta aacagcgagg aggagcgcat tttgcgctac gtgcagcaga 17640

gcgtgagcct taacctgatg cgcgacgggg taacgcccag cgtggcgctg gacatgaccg 17700

cgcgcaacat ggaaccgggc atgtatgcct caaaccggcc gtttatcaac cgcctaatgg 17760

actacttgca tcgcgcggcc gccgtgaacc ccgagtattt caccaatgcc atcttgaacc 17820

cgcactggct accgccccct ggtttctaca ccgggggatt cgaggtgccc gagggtaacg 17880

atggattcct ctgggacgac atagacgaca gcgtgttttc cccgcaaccg cagaccctgc 17940

tagagttgca acagcgcgag caggcagagg cggcgctgcg aaaggaaagc ttccgcaggc 18000

caagcagctt gtccgatcta ggcgctgcgg ccccgcggtc agatgctagt agcccatttc 18060

caagcttgat agggtctctt accagcactc gcaccacccg cccgcgcctg ctgggcgagg 18120

aggagtacct aaacaactcg ctgctgcagc cgcagcgcga aaaaaacctg cctccggcat 18180

ttcccaacaa cgggatagag agcctagtgg acaagatgag tagatggaag acgtacgcgc 18240

aggagcacag ggacgtgcca ggcccgcgcc cgcccacccg tcgtcaaagg cacgaccgtc 18300

agcggggtct ggtgtgggag gacgatgact cggcagacga cagcagcgtc ctggatttgg 18360

gagggagtgg caacccgttt gcgcaccttc gccccaggct ggggagaatg ttttaaaaaa 18420

aaaaaagcat gatgcaaaat aaaaaactca ccaaggccat ggcaccgagc gttggttttc 18480

ttgtattccc cttagtatgc ggcgcgcggc gatgtatgag gaaggtcctc ctccctccta 18540

cgagagtgtg gtgagcgcgg cgccagtggc ggcggcgctg ggttctccct tcgatgctcc 18600

cctggacccg ccgtttgtgc ctccgcggta cctgcggcct accgggggga gaaacagcat 18660

ccgttactct gagttggcac ccctattcga caccacccgt gtgtacctgg tggacaacaa 18720

gtcaacggat gtggcatccc tgaactacca gaacgaccac agcaactttc tgaccacggt 18780

cattcaaaac aatgactaca gcccggggga ggcaagcaca cagaccatca atcttgacga 18840

ccggtcgcac tggggcggcg acctgaaaac catcctgcat accaacatgc caaatgtgaa 18900

cgagttcatg tttaccaata agtttaaggc gcgggtgatg gtgtcgcgct tgcctactaa 18960

ggacaatcag gtggagctga aatacgagtg ggtggagttc acgctgcccg agggcaacta 19020

ctccgagacc atgaccatag accttatgaa caacgcgatc gtggagcact acttgaaagt 19080

gggcagacag aacggggttc tggaaagcga catcggggta aagtttgaca cccgcaactt 19140

cagactgggg tttgaccccg tcactggtct tgtcatgcct ggggtatata caaacgaagc 19200

cttccatcca gacatcattt tgctgccagg atgcggggtg gacttcaccc acagccgcct 19260

gagcaacttg ttgggcatcc gcaagcggca acccttccag gagggcttta ggatcaccta 19320

cgatgatctg gagggtggta acattcccgc actgttggat gtggacgcct accaggcgag 19380

cttgaaagat gacaccgaac agggcggggg tggcgcaggc ggcagcaaca gcagtggcag 19440

cggcgcggaa gagaactcca acgcggcagc cgcggcaatg cagccggtgg aggacatgaa 19500

cgatcatgcc attcgcggcg acacctttgc cacacgggct gaggagaagc gcgctgaggc 19560

cgaagcagcg gccgaagctg ccgcccccgc tgcgcaaccc gaggtcgaga agcctcagaa 19620

gaaaccggtg atcaaacccc tgacagagga cagcaagaaa cgcagttaca acctaataag 19680

caatgacagc accttcaccc agtaccgcag ctggtacctt gcatacaact acggcgaccc 19740

tcagaccgga atccgctcat ggaccctgct ttgcactcct gacgtaacct gcggctcgga 19800

gcaggtctac tggtcgttgc cagacatgat gcaagacccc gtgaccttcc gctccacgcg 19860

ccagatcagc aactttccgg tggtgggcgc cgagctgttg cccgtgcact ccaagagctt 19920

ctacaacgac caggccgtct actcccaact catccgccag tttacctctc tgacccacgt 19980

gttcaatcgc tttcccgaga accagatttt ggcgcgcccg ccagccccca ccatcaccac 20040

cgtcagtgaa aacgttcctg ctctcacaga tcacgggacg ctaccgctgc gcaacagcat 20100

cggagggagtc cagcgagtga ccattactga cgccagacgc cgcacctgcc cctacgttta 20160

caaggccctg ggcatagtct cgccgcgcgt cctatcgagc cgcacttttt gagcaagcat 20220

gtccatcctt atatcgccca gcaataacac aggctggggc ctgcgcttcc caagcaagat 20280

gtttggcggg gccaagaagc gctccgacca acacccagtg cgcgtgcgcg ggcactaccg 20340

cgcgccctgg ggcgcgcaca aacgcggccg cactgggcgc accaccgtcg atgacgccat 20400

cgacgcggtg gtggaggagg cgcgcaacta cacgcccacg ccgccaccag tgtccacagt 20460

ggacgcggcc attcagaccg tggtgcgcgg agcccggcgc tatgctaaaa tgaagagacg 20520

gcggaggcgc gtagcacgtc gccaccgccg ccgacccggc actgccgccc aacgcgcggc 20580

ggcggccctg cttaaccgcg cacgtcgcac cggccgacgg gcggccatgc gggccgctcg 20640

aaggctggcc gcgggtattg tcactgtgcc ccccaggtcc aggcgacgag cggccgccgc 20700

agcagccgcg gccattagtg ctatgactca gggtcgcagg ggcaacgtgt attgggtgcg 20760

cgactcggtt agcggcctgc gcgtgcccgt gcgcacccgc cccccgcgca actagattgc 20820

aagaaaaaac tacttagact cgtactgttg tatgtatcca gcggcggcgg cgcgcaacga 20880

agctatgtcc aagcgcaaaa tcaaagaaga gatgctccag gtcatcgcgc cggagatcta 20940

tggccccccg aagaaggaag agcaggatta caagccccga aagctaaagc gggtcaaaaa 21000

gaaaaagaaa gatgatgatg atgaacttga cgacgaggtg gaactgctgc acgctaccgc 21060

gcccaggcga cgggtacagt ggaaaggtcg acgcgtaaaa cgtgttttgc gacccggcac 21120

caccgtagtc tttacgcccg gtgagcgctc cacccgcacc tacaagcgcg tgtatgatga 21180

ggtgtacggc gacgaggacc tgcttgagca ggccaacgag cgcctcgggg agtttgccta 21240

cggaaagcgg cataaggaca tgctggcgtt gccgctggac gagggcaacc caacacctag 21300

cctaaagccc gtaacactgc agcaggtgct gcccgcgctt gcaccgtccg aagaaaagcg 21360

cggcctaaag cgcgagtctg gtgacttggc acccaccgtg cagctgatgg tacccaagcg 21420

ccagcgactg gaagatgtct tggaaaaaat gaccgtggaa cctgggctgg agcccgaggt 21480

ccgcgtgcgg ccaatcaagc aggtggcgcc gggactgggc gtgcagaccg tggacgttca 21540

gatacccact accagtagca ccagtattgc caccgccaca gagggcatgg agacacaaac 21600

gtccccggtt gcctcagcgg tggcggatgc cgcggtgcag gcggtcgctg cggccgcgtc 21660

caagacctct acggaggtgc aaacggaccc gtggatgttt cgcgtttcag ccccccggcg 21720

cccgcgccgt tcgaggaagt acggcgccgc cagcgcgcta ctgcccgaat atgccctaca 21780

tccttccatt gcgcctaccc ccggctatcg tggctacacc taccgcccca gaagacgagc 21840

aactacccga cgccgaacca ccactggaac ccgccgccgc cgtcgccgtc gccagcccgt 21900

gctggccccg atttccgtgc gcagggtggc tcgcgaagga ggcaggaccc tggtgctgcc 21960

aacagcgcgc taccacccca gcatcgttta aaagccggtc tttgtggttc ttgcagatat 22020

ggccctcacc tgccgcctcc gtttcccggt gccggggattc cgaggaagaa tgcaccgtag 22080

gaggggcatg gccggccacg gcctgacggg cggcatgcgt cgtgcgcacc accggcggcg 22140

gcgcgcgtcg caccgtcgca tgcgcggcgg tatcctgccc ctccttattc cactgatcgc 22200

cgcggcgatt ggcgccgtgc ccggaattgc atccgtggcc ttgcaggcgc agagacactg 22260

attaaaaaca agttgcatgt ggaaaaatca aaataaaaag tctggactct cacgctcgct 22320

tggtcctgta actattttgt agaatggaag acatcaactt tgcgtctctg gccccgcgac 22380

acggctcgcg cccgttcatg ggaaactggc aagatatcgg caccagcaat atgagcggtg 22440

gcgccttcag ctggggctcg ctgtggagcg gcattaaaaa tttcggttcc accgttaaga 22500

actatggcag caaggcctgg aacagcagca caggccagat gctgagggat aagttgaaag 22560

agcaaaattt ccaacaaaag gtggtagatg gcctggcctc tggcattagc ggggtggtgg 22620

acctggccaa ccaggcagtg caaaataaga ttaacagtaa gcttgatccc cgccctcccg 22680

tagaggagcc tccaccggcc gtggagacag tgtctccaga ggggcgtggc gaaaagcgtc 22740

cgcgccccga cagggaagaa actctggtga cgcaaataga cgagcctccc tcgtacgagg 22800

aggcactaaa gcaaggcctg cccaccaccc gtcccatcgc gcccatggct accggagtgc 22860

tgggccagca cacacccgta acgctggacc tgcctccccc cgccgacacc cagcagaaac 22920

ctgtgctgcc aggcccgacc gccgttgttg taacccgtcc tagccgcgcg tccctgcgcc 22980

gcgccgccag cggtccgcga tcgttgcggc ccgtagccag tggcaactgg caaagcacac 23040

tgaacagcat cgtgggtctg ggggtgcaat ccctgaagcg ccgacgatgc ttctgatagc 23100

taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag ctgctgagcc 23160

gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg gtcttacatg 23220

cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca gtttgcccgc 23280

gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt ggcgcctacg 23340

cacgacgtga cccacagaccg gtcccagcgt ttgacgctgc ggttcatccc tgtggaccgt 23400

gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga taaccgtgtg 23460

ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg ccctactttt 23520

aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc aaatccttgc 23580

gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga cgatgacaac 23640

gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg gcaggcgcct 23700

tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg tcaaacacct 23760

aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca gtggtacgaa 23820

acagaaatta atcatgcagc tgggagagtc ctaaaaaaga ctaccccaat gaaaccatgt 23880

tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct tgtaaagcaa 23940

caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac tgaggcagcc 24000

gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga tgtagatata 24060

gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa ctcacgagaa 24120

ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag ggacaatttt 24180

attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg ccaagcatcg 24240

cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata ccagcttttg 24300

cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc tgttgacagc 24360

tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact tccaaattac 24420

tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa acctaaaaca 24480

ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa tgaaataaga 24540

gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag aaatttcctg 24600

tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc caacgtaaaa 24660

atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc tcccgggcta 24720

gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga caacgtcaac 24780

ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct gggcaatggt 24840

cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa aaacctcctt 24900

ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa catggttctg 24960

cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt tgatagcatt 25020

tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct tgaggccatg 25080

cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc caacatgctc 25140

taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg caactgggcg 25200

gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc actgggctcg 25260

ggctacgacc cttattacac ctactctggc tctataccct acctagatgg aaccttttac 25320

ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag ctggcctggc 25380

aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga cggggagggt 25440

tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat gctagctaac 25500

tataacattg gctaccaggg cttctatatc ccagagagct acaaggaccg catgtactcc 25560

ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa atacaaggac 25620

taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg ctaccttgcc 25680

cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct tataggcaag 25740

accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct ttggcgcatc 25800

ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca aaaccttctc 25860

tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat ggacgagccc 25920

acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcacca gccgcaccgc 25980

ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc cacaacataa 26040

agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag gaactgaaag 26100

ccattgtcaa agatcttggt tgtggggccat attttttggg cacctatgac aagcgctttc 26160

caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc ggtcgcgaga 26220

ctggggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca tgctacctct 26280

ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt gagtacgagt 26340

cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg ctggaaaagt 26400

ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc tgcatgtttc 26460

tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc atgaacctta 26520

ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc ctgcgtcgca 26580

accaccaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc agccacagtg 26640

cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa taatgtacta 26700

gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga ttatttaccc 26760

ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca tcgctatgcg 26820

ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac tcaggcacaa 26880

ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc accaacgcgt 26940

ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc tgcgcgcgcg 27000

agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg tgcacgctgg 27060

ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg ctcagggcga 27120

acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc tttgagttgc 27180

actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta ggatacagcg 27240

cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct tcagagaaga 27300

acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg tgcacgcagc 27360

accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc ttcacgatct 27420

tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc acatccattt 27480

caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc tcgccttcga 27540

tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc ttgtaggtca 27600

cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc acaaaggtct 27660

tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag gtcttgcata 27720

cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt agatcgttat 27780

ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc cacgcagaca 27840

cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg ctgggctctt 27900

cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc agccgccgca 27960

ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg aaacccacca 28020

tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct ggtgatggcg 28080

ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg gccaaatccg 28140

ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct tgtgatgagt 28200

cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc gcccggggag 28260

gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt cgcgccgcac 28320

cgcgtccgcg ctcggggggtg gtttcgcgct gctcctcttc ccgactggcc atttccttct 28380

cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta accgccccct 28440

ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc ttccccgtcg 28500

aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt tttgtaagcg 28560

aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag gacaacgcag 28620

aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac ctagatgtgg 28680

gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc gacgcgttgc 28740

aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac gaacgccacc 28800

tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag cccaacccgc 28860

gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat cacatctttt 28920

tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg gacaagcagc 28980

tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa gtgccaaaaa 29040

tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa caggaaaaca 29100

gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac gcgcgcctag 29160

ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt aacctacccc 29220

ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag cccctggaga 29280

gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc gacgagcagc 29340

tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc aaactaatga 29400

tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt gctgacccgg 29460

agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc tacgtacgcc 29520

aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt ggaattttgc 29580

acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag gcgcgccgcg 29640

actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg gccatgggcg 29700

tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg ctaaagcaaa 29760

acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac ctggcggaca 29820

tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac ttcaccagtc 29880

aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc ttgcccgcca 29940

cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc cctccgccgc 30000

tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac tctgacataa 30060

tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac ctatgcaccc 30120

cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt atcggtacct 30180

ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg aaactcactc 30240

cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac cacgcccacg 30300

agattaggtt ctacgaagac caatcccgcc cgcctaatgc ggagcttacc gcctgcgtca 30360

ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc caagagtttc 30420

tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag ctcaacccaa 30480

tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc caggatggca 30540

cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata ctgggacagt 30600

caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg ggagagccta 30660

gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc ctcggtcgca 30720

ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac aacctccgct 30780

cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga caccactgga 30840

accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca acagcgccaa 30900

ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca agactgtggg 30960

ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc cttcccccgt 31020

aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg cagcggcagc 31080

aacagcagcg gccacacaga agcaaaggcg accggatagc aagactctga caaagcccaa 31140

gaaatccaca gcggcggcag cagcaggagg aggagcgctg cgtctggcgc ccaacgaacc 31200

cgtatcgacc cgcgagctta gaaacaggat ttttcccact ctgtatgcta tatttcaaca 31260

gagcaggggc caagaacaag agctgaaaat aaaaaacagg tctctgcgat ccctcacccg 31320

cagctgcctg tatcacaaaa gcgaagatca gcttcggcgc acgctggaag acgcggaggc 31380

tctcttcagt aaatactgcg cgctgactct taaggactag tttcgcgccc tttctcaaat 31440

ttaagcgcga aaactacgtc atctccagcg gccacacccg gcgccagcac ctgttgtcag 31500

cgccattatg agcaaggaaa ttcccacgcc ctacatgtgg agttaccagc cacaaatggg 31560

acttgcggct ggagctgccc aagactactc aacccgaata aactacatga gcgcgggacc 31620

ccacatgata tcccggggtca acggaatacg cgcccaccga aaccgaattc tcctggaaca 31680

ggcggctatt accaccacac ctcgtaataa ccttaatccc cgtagttggc ccgctgccct 31740

ggtgtaccag gaaagtcccg ctcccaccac tgtggtactt cccagagacg cccaggccga 31800

agttcagatg actaactcag gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc 31860

gcccgggcag ggtataactc acctgacaat cagagggcga ggtattcagc tcaacgacga 31920

gtcggtgagc tcctcgcttg gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg 31980

ccgctcttca ttcacgcctc gtcaggcaat cctaactctg cagacctcgt cctctgagcc 32040

gcgctctgga ggcattggaa ctctgcaatt tattgaggag tttgtgccat cggtctactt 32100

taaccccttc tcgggacctc ccggccacta tccggatcaa tttattccta actttgacgc 32160

ggtaaaggac tcggcggacg gctacgactg aatgttaagt ggagaggcag agcaactgcg 32220

cctgaaacac ctggtccact gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt 32280

ttgctacttt gaattgcccg aggatcatat cgagggcccg gcgcacggcg tccggcttac 32340

cgcccaggga gagcttgccc gtagcctgat tcgggagttt acccagcgcc ccctgctagt 32400

tgagcgggac aggggaccct gtgttctcac tgtgatttgc aactgtccta accctggatt 32460

acatcaagat cctctagtta atgtcaggtc gcctaagtcg attaactaga gtacccgggg 32520

atcttattcc ctttaactaa taaaaaaaaa taataaagca tcacttactt aaaatcagtt 32580

agcaaatttc tgtccagttt attcagcagc acctccttgc cctcctccca gctctggtat 32640

tgcagcttcc tcctggctgc aaactttctc cacaatctaa atggaatgtc agtttcctcc 32700

tgttcctgtc catccgcacc cactatcttc atgttgttgc agatgaagcg cgcaagaccg 32760

tctgaagata ccttcaaccc cgtgtatcca tatgacacgg aaaccggtcc tccaactgtg 32820

ccttttctta ctcctccctt tgtatccccc aatgggtttc aagagagtcc ccctggggta 32880

ctctctttgc gcctatccga acctctagtt acctccaatg gcatgcttgc gctcaaaatg 32940

ggcaacggcc tctctctgga cgaggccggc aaccttacct cccaaaatgt aaccactgtg 33000

agcccacctc tcaaaaaaac caagtcaaac ataaacctgg aaatatctgc acccctcaca 33060

gttacctcag aagccctaac tgtggctgcc gccgcacctc taatggtcgc gggcaacaca 33120

ctcaccatgc aatcacaggc cccgctaacc gtgcacgact ccaaacttag cattgccacc 33180

caaggacccc tcacagtgtc agaaggaaag ctagccctgc aaacatcagg ccccctcacc 33240

accaccgata gcagtaccct tactatcact gcctcacccc ctctaactac tgccactggt 33300

agcttgggca ttgacttgaa agagcccatt tatacacaaa atggaaaact aggactaaag 33360

tacggggctc ctttgcatgt aacagacgac ctaaacactt tgaccgtagc aactggtcca 33420

ggtgtgacta ttaataatac ttccttgcaa actaaagtta ctggagcctt gggttttgat 33480

tcacaaggca atatgcaact taatgtagca ggaggactaa ggattgattc tcaaaacaga 33540

cgccttatac ttgatgttag ttatccgttt gatgctcaaa accaactaaa tctaagacta 33600

ggacagggcc ctctttttat aaactcagcc cacaacttgg atattaacta caacaaaggc 33660

ctttacttgt ttacagcttc aaacaattcc aaaaagcttg aggttaacct aagcactgcc 33720

aaggggttga tgtttgacgc tacagccata gccattaatg caggagatgg gcttgaattt 33780

ggttcaccta atgcaccaaa cacaaatccc ctcaaaacaa aaattggcca tggcctagaa 33840

tttgattcaa acaaggctat ggttcctaaa ctaggaactg gccttagttt tgacagcaca 33900

ggtgccatta cagtaggaaa caaaaataat gataagctaa ctttgtggac cggaataaac 33960

cctccaccta actgtcaaat tgtggaaaac actaatacaa atgatggcaa acttacttta 34020

gtattagtaa aaaatggagg gcttgttaat ggctacgtgt ctctagttgg tgtatcagac 34080

actgtgaacc aaatgttcac acaaaagaca gcaaacatcc aattaagatt atattttgac 34140

tcttctggaa atctattaac tgaggaatca gacttaaaaa ttccacttaa aaataaatct 34200

tctacagcga ccagtgaaac tgtagccagc agcaaagcct ttatgccaag tactacagct 34260

tatcccttca acaccactac tagggatagt gaaaactaca ttcatggaat atgttactac 34320

atgactagtt atgatagaag tctatttccc ttgaacattt ctataatgct aaacagccgt 34380

atgatttctt ccaatgttgc ctatgccata caatttgaat ggaatctaaa tgcaagtgaa 34440

tctccagaaa gcaacatagc tacgctgacc acatccccct ttttcttttc ttacattaca 34500

gaagacgaca actaaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 34560

gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata gcttatacag 34620

atcaccgtac cttaatcaaa ctcacagaac cctagtattc aacctgccac ctccctccca 34680

acacacagag tacacagtcc tttctccccg gctggcctta aaaagcatca tatcatgggt 34740

aacagacata ttcttaggtg ttatattcca cacggtttcc tgtcgagcca aacgctcatc 34800

agtgatatta ataaactccc cgggcagctc acttaagttc atgtcgctgt ccagctgctg 34860

agccacaggc tgctgtccaa cttgcggttg cttaacgggc ggcgaaggag aagtccacgc 34920

ctacatgggg gtagagtcat aatcgtgcat caggataggg cggtggtgct gcagcagcgc 34980

gcgaataaac tgctgccgcc gccgctccgt cctgcaggaa tacaacatgg cagtggtctc 35040

ctcagcgatg attcgcaccg cccgcagcat aaggcgcctt gtcctccggg cacagcagcg 35100

caccctgatc tcacttaaat cagcacagta actgcagcac agcaccacaa tattgttcaa 35160

aatcccacag tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag aacccacgtg 35220

gccatcatac cacaagcgca ggtagattaa gtggcgaccc ctcataaaca cgctggacat 35280

aaacattacc tcttttggca tgttgtaatt caccacctcc cggtaccata taaacctctg 35340

attaaacatg gcgccatcca cccacatcct aaaccagctg gccaaaacct gcccgccggc 35400

tatacactgc agggaaccgg gactggaaca atgacagtgg agagcccagg actcgtaacc 35460

atggatcatc atgctcgtca tgatatcaat gttggcacaa cacaggcaca cgtgcataca 35520

cttcctcagg attacaagct cctcccgcgt tagaaccata tcccagggaa caacccattc 35580

ctgaatcagc gtaaatccca cactgcaggg aagacctcgc acgtaactca cgttgtgcat 35640

tgtcaaagtg ttacattcgg gcagcagcgg atgatcctcc agtatggtag cgcgggtttc 35700

tgtctcaaaa ggaggtagac gatccctact gtacggagtg cgccgagaca accgagatcg 35760

tgttggtcgt agtgtcatgc caaatggaac gccggacgta gtcatatttc ctgaagcaaa 35820

accaggtgcg ggcgtgacaa acagatctgc gtctccggtc tcgccgctta gatcgctctg 35880

tgtagtagtt gtagtatatc cactctctca aagcatccag gcgccccctg gcttcgggtt 35940

ctatgtaaac tccttcatgc gccgctgccc tgataacatc caccaccgca gaataagcca 36000

cacccagcca acctacacat tcgttctgcg agtcacacac gggaggagcg ggaagagctg 36060

gaagaaccat gttttttttt ttattccaaa agattatcca aaacctcaaa atgaagatct 36120

attaagtgaa cgcgctcccc tccggtggcg tggtcaaact ctacagccaa agaacagata 36180

atggcatttg taagatgttg cacaatggct tccaaaaggc aaacggccct cacgtccaag 36240

tggacgtaaa ggctaaaccc ttcagggtga atctcctcta taaacattcc agcaccttca 36300

accatgccca aataattctc atctcgccac cttctcaata tatctctaag caaatcccga 36360

atattaagtc cggccattgt aaaaatctgc tccagagcgc cctccacctt cagcctcaag 36420

cagcgaatca tgattgcaaa aattcaggtt cctcacagac ctgtataaga ttcaaaagcg 36480

gaacattaac aaaaataccg cgatcccgta ggtcccttcg cagggccagc tgaacataat 36540

cgtgcaggtc tgcacggacc agcgcggcca cttccccgcc aggaaccatg acaaaagaac 36600

cccacactgat tatgacacgc atactcggag ctatgctaac cagcgtagcc ccgatgtaag 36660

cttgttgcat gggcggcgat ataaaatgca aggtgctgct caaaaaatca ggcaaagcct 36720

cgcgcaaaaa agaaagcaca tcgtagtcat gctcatgcag ataaaggcag gtaagctccg 36780

gaaccaccac agaaaaagac accatttttc tctcaaacat gtctgcgggt ttctgcataa 36840

acacaaaata aaataacaaa aaaacattta aacattagaa gcctgtctta caacaggaaa 36900

aacaaccctt ataagcataa gacggactac ggccatgccg gcgtgaccgt aaaaaaactg 36960

gtcaccgtga ttaaaaagca ccaccgacag ctcctcggtc atgtccggag tcataatgta 37020

agactcggta aacacatcag gttgattcac atcggtcagt gctaaaaagc gaccgaaata 37080

gcccggggga atacataccc gcaggcgtag agacaacatt acagccccca taggaggtat 37140

aacaaaatta ataggagaga aaaacacata aacacctgaa aaaccctcct gcctaggcaa 37200

aatagcaccc tcccgctcca gaacaacata cagcgcttcc acagcggcag ccataacagt 37260

cagccttacc agtaaaaaag aaaacctatt aaaaaaacac cactcgacac ggcaccagct 37320

caatcagtca cagtgtaaaa aagggccaag tgcagagcga gtatatatag gactaaaaaa 37380

tgacgtaacg gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca 37440

gaaacgaaag ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt tcccacgtta 37500

cgtcacttcc cattttaaga aaactacaat tcccaacaca tacaagttac tccgccctaa 37560

aacctacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc caccccctca 37620

ttatcatatt ggcttcaatc caaaataagg tatattattg atgatg 37666

<210> 25

<211> 34727

<212> DNA

<213> Artificial sequence

<220>

<223> vector #2

<400> 25

catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tactgtaata gtaatcaatt 360

acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420

ggcccgcctg gctgaccgcc caacgacccc cgcccatga cgtcaataat gacgtatgtt 480

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660

acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720

tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt 780

gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840

aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900

agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020

agacaccggg accgatccag cctccgattt gccaccatgt ttgtgttcct ggtgctgctg 1080

ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc tcctgcctac 1140

accaactcct tcaccagggg agtctactac cctgacaagg tgttcaggtc ctctgtgctg 1200

cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt ccatgccatc 1260

catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc attcaatgat 1320

ggagtctact ttgccagcac agagaagagc aacatcatca ggggctggat ttttggcacc 1380

accctggaca gcaagacca gtccctgctg attgtgaaca atgccaccaa tgtggtgatt 1440

aaggtgtgtg agttccagtt ctgtaatgac ccattcctgg gagtctacta ccacaagaac 1500

aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa ctgtaccttt 1560

gaatatgtga gccaaccatt cctgatggac ttggagggca agcagggcaa cttcaagaac 1620

ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag caaacacaca 1680

ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc actggtggac 1740

ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca caggtcctac 1800

ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta ctatgtgggc 1860

tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat cacagatgct 1920

gtggactgtg ccctggaccc actgtctgag accaagtgta ccctgaaatc cttcacagtg 1980

gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag cattgtgagg 2040

tttccaaaca tcaccaacct gtgtccatt ggagaggtgt tcaatgccac caggtttgcc 2100

tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta ctctgtgctc 2160

tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac caaactgaat 2220

gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga tgaggtgaga 2280

cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact gcctgatgac 2340

ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt gggaggcaac 2400

tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga gagggacatc 2460

agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg cttcaactgt 2520

tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta ccaaccatac 2580

agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgtg tggaccaaag 2640

aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg actgacaggc 2700

acaggagtgc tgacagagag caacaagaag ttcctgccat tccaacagtt tggcagggac 2760

attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct ggacatcaca 2820

ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag caaccaggtg 2880

gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca tgctgaccaa 2940

cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac cagggctggc 3000

tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc aattggagca 3060

ggcatctgtg cctcctacca gacccagacc atcctcaggt ctgtggcaag cgagagcatc 3120

attgcctaca caatgagtct gggagcagag aactctgtgg cttacagcaa caacagcatt 3180

gccatcccaa ccaacttcac catctctgtg accacagaga ttctgcctgt gagtatgacc 3240

aagacctctg tggactgtac aatgtatatc tgtggagaca gcacagagtg tagcaacctg 3300

ctgctccaat atggctcctt ctgtacccaa cttaacaggg ctctgacagg cattgctgtg 3360

gaacaggaca agaacaccca ggaggtgttt gcccaggtga agcagattta caagacacct 3420

ccaatcaagg actttggagg cttcaacttc agccagattc tgcctgaccc aagcaagcca 3480

agcaagaggt ccttcattga ggacctgctg ttcaacaagg tgaccctggc tgatgctggc 3540

ttcatcaagc aatatggaga ctgtctggga gacattgctg ccagggacct gatttgtgcc 3600

cagaagttca atggactgac agtgctgcct ccactgctga cagatgagat gattgcccaa 3660

tacacctctg ccctgctggc tggcaccatc acctctggct ggacctttgg agcaggagca 3720

gccctccaaa tcccatttgc tatgcagatg gcttacaggt tcaatggcat tggagtgacc 3780

cagaatgtgc tctatgagaa ccagaaactg attgccaacc agttcaactc tgccattggc 3840

aagattcagg actccctgtc cagcacagcc tctgccctgg gcaaactcca agatgtggtg 3900

aaccagaatg cccaggctct gaacaccctg gtgaagcaac tttccagcaa ctttggagcc 3960

atctcctctg tgctgaatga catcctgagc agactggaca aggtggaggc tgaggtccag 4020

attgacagac tgattacagg cagactccaa tccctccaaa cctatgtgac ccaacaactt 4080

atcagggctg ctgagattag ggcatctgcc aacctggctg ccaccaagat gagtgagtgt 4140

gtgctgggac aaagcaagag ggtggacttc tgtggcaagg gctaccacct gatgagtttt 4200

ccacagtctg cccctcatgg agtggtgttc ctgcatgtga cctatgtgcc tgcccaggag 4260

aagaacttca ccacagcccc tgccatctgc catgatggca aggctcactt tccaagggag 4320

ggagtgtttg tgagcaatgg cacccactgg tttgtgaccc agaggaactt ctatgaacca 4380

cagattatca ccacagacaa cacctttgtg tctggcaact gtgatgtggt gattggcatt 4440

gtgaacaaca cagtctatga cccactccaa cctgaactgg actccttcaa ggaggaactg 4500

gacaaatact tcaagaacca caccagccct gatgtggacc tgggagacat ctctggcatc 4560

aatgcctctg tggtgaacat ccagaaggag attgacagac tgaatgaggt ggctaagaac 4620

ctgaatgagt ccctgattga cctccaagaa ctgggcaaat atgaacaata catcaagtgg 4680

ccatgaaaat tgatcataat cagccatacc acatttgtag aggttttact tgctttaaaa 4740

aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac 4800

ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 4860

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttaa 4920

cgcggatctg ggcgtggtta agggtgggaa agaatatata aggtgggggt cttatgtagt 4980

tttgtatctg ttttgcagca gccgccgccg ccatgagcac caactcgttt gatggaagca 5040

ttgtgagctc atatttgaca acgcgcatgc ccccatgggc cggggtgcgt cagaatgtga 5100

tgggctccag cattgatggt cgccccgtcc tgcccgcaaa ctctactacc ttgacctacg 5160

agaccgtgtc tggaacgccg ttggagactg cagcctccgc cgccgcttca gccgctgcag 5220

ccaccgcccg cgggattgtg actgactttg ctttcctgag cccgcttgca agcagtgcag 5280

cttcccgttc atccgcccgc gatgacaagt tgacggctct tttggcacaa ttggattctt 5340

tgacccggga acttaatgtc gtttctcagc agctgttgga tctgcgccag caggtttctg 5400

ccctgaaggc ttcctcccct cccaatgcgg tttaaaacat aaataaaaaa ccagactctg 5460

tttggatttg gatcaagcaa gtgtcttgct gtctttattt aggggttttg cgcgcgcggt 5520

aggcccggga ccagcggtct cggtcgttga gggtcctgtg tattttttcc aggacgtggt 5580

aaaggtgact ctggatgttc agatacatgg gcataagccc gtctctgggg tggaggtagc 5640

accactgcag agcttcatgc tgcggggtgg tgttgtagat gatccagtcg tagcaggagc 5700

gctgggcgtg gtgcctaaaa atgtctttca gtagcaagct gattgccagg ggcaggccct 5760

tggtgtaagt gtttacaaag cggttaagct gggatgggtg catacgtggg gatatgagat 5820

gcatcttgga ctgtattttt aggttggcta tgttcccagc catatccctc cggggattca 5880

tgttgtgcag aaccaccagc acagtgtatc cggtgcactt gggaaatttg tcatgtagct 5940

tagaaggaaa tgcgtggaag aacttggaga cgcccttgtg acctccaaga ttttccatgc 6000

attcgtccat aatgatggca atgggcccac gggcggcggc ctgggcgaag atatttctgg 6060

gatcactaac gtcatagttg tgttccagga tgagatcgtc ataggccatt tttacaaagc 6120

gcgggcggag ggtgccagac tgcggtataa tggttccatc cggcccaggg gcgtagttac 6180

cctcacagat ttgcatttcc cacgctttga gttcagatgg ggggatcatg tctacctgcg 6240

gggcgatgaa gaaaacggtt tccggggtag gggagatcag ctgggaagaa agcaggttcc 6300

tgagcagctg cgacttaccg cagccggtgg gcccgtaaat cacacctatt accggctgca 6360

actggtagtt aagagagctg cagctgccgt catccctgag caggggggcc acttcgttaa 6420

gcatgtccct gactcgcatg ttttccctga ccaaatccgc cagaaggcgc tcgccgccca 6480

gcgatagcag ttcttgcaag gaagcaaagt ttttcaacgg tttgagaccg tccgccgtag 6540

gcatgctttt gagcgtttga ccaagcagtt ccaggcggtc ccacagctcg gtcacctgct 6600

ctacggcatc tcgatccagc atatctcctc gtttcgcggg ttggggcggc tttcgctgta 6660

cggcagtagt cggtgctcgt cgacgggc cagggtcatg tctttccacg ggcgcagggt 6720

cctcgtcagc gtagtctggg tcacggtgaa ggggtgcgct ccgggctgcg cgctggccag 6780

ggtgcgcttg aggctggtcc tgctggtgct gaagcgctgc cggtcttcgc cctgcgcgtc 6840

ggccaggtag catttgacca tggtgtcata gtccagcccc tccgcggcgt ggcccttggc 6900

gcgcagcttg cccttggagg aggcgccgca cgaggggcag tgcagacttt tgaggcgta 6960

gagcttgggc gcgagaaata ccgattccgg ggagtaggca tccgcgccgc aggccccgca 7020

gacggtctcg cattccacga gccaggtgag ctctggccgt tcggggtcaa aaaccaggtt 7080

tcccccatgc tttttgatgc gtttcttacc tctggtttcc atgagccggt gtccacgctc 7140

ggtgacgaaa aggctgtccg tgtccccgta tacagacttg agaggcctgt cctcgagcgg 7200

tgttccgcgg tcctcctcgt atagaaactc ggaccactct gagacaaagg ctcgcgtcca 7260

ggccagcacg aaggaggcta agtgggagg gtagcggtcg ttgtccacta gggggtccac 7320

tcgctccagg gtgtgaagac acatgtcgcc ctcttcggca tcaaggaagg tgattggttt 7380

gtaggtgtag gccacgtgac cgggtgttcc tgaagggggg ctataaaagg gggtggggggc 7440

gcgttcgtcc tcactctctt ccgcatcgct gtctgcgagg gccagctgtt ggggtgagta 7500

ctccctctga aaagcgggca tgacttctgc gctaagattg tcagtttcca aaaacgagga 7560

ggatttgata ttcacctggc ccgcggtgat gcctttgagg gtggccgcat ccatctggtc 7620

agaaaagaca atctttttgt tgtcaagctt ggtggcaaac gacccgtaga gggcgttgga 7680

cagcaacttg gcgatggagc gcagggtttg gtttttgtcg cgatcggcgc gctccttggc 7740

cgcgatgttt agctgcacgt attcgcgcgc aacgcaccgc cattcgggaa agacggtggt 7800

gcgctcgtcg ggcaccaggt gcacgcgcca accgcggttg tgcagggtga caaggtcaac 7860

gctggtggct acctctccgc gtaggcgctc gttggtccag cagaggcggc cgcccttgcg 7920

cgagcagaat ggcggtaggg ggtctagctg cgtctcgtcc ggggggtctg cgtccacggt 7980

aaagaccccg ggcagcaggc gcgcgtcgaa gtagtctatc ttgcatcctt gcaagtctag 8040

cgcctgctgc catgcgcggg cggcaagcgc gcgctcgtat gggttgagtg ggggacccca 8100

tggcatgggg tgggtgagcg cggaggcgta catgccgcaa atgtcgtaaa cgtagagggg 8160

ctctctgagt attccaagat atgtagggta gcatcttcca ccgcggatgc tggcgcgcac 8220

gtaatcgtat agttcgtgcg agggagcgag gaggtcggga ccgaggttgc tacgggcggg 8280

ctgctctgct cggaagacta tctgcctgaa gatggcatgt gagttggatg atatggttgg 8340

acgctggaag acgttgaagc tggcgtctgt gagacctacc gcgtcacgca cgaaggaggc 8400

gtaggagtcg cgcagcttgt tgaccagctc ggcggtgacc tgcacgtcta gggcgcagta 8460

gtccagggtt tccttgatga tgtcatactt atcctgtccc ttttttttcc acagctcgcg 8520

gttgaggaca aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc 8580

cgaacggtaa gagcctagca tgtagaactg gttgacggcc tggtaggcgc agcatccctt 8640

ttctacgggt agcgcgtatg cctgcgcggc cttccggagc gaggtgtggg tgagcgcaaa 8700

ggtgtccctg accatgactt tgaggtactg gtatttgaag tcagtgtcgt cgcatccgcc 8760

ctgctcccag agcaaaaagt ccgtgcgctt tttggaacgc ggatttggca gggcgaaggt 8820

gacatcgttg aagagtatct ttcccgcgcg aggcataaag ttgcgtgtga tgcggaaggg 8880

tcccggcacc tcggaacggt tgttaattac ctgggcggcg agcacgatct cgtcaaagcc 8940

gttgatgttg tggcccacaa tgtaaagttc caagaagcgc gggatgccct tgatggaagg 9000

caatttttta agttcctcgt aggtgagctc ttcaggggag ctgagcccgt gctctgaaag 9060

ggcccagtct gcaagatgag ggttggaagc gacgaatgag ctccacaggt cacgggccat 9120

tagcatttgc aggtggtcgc gaaaggtcct aaactggcga cctatggcca ttttttctgg 9180

ggtgatgcag tagaaggtaa gcgggtcttg ttcccagcgg tcccatccaa ggttcgcggc 9240

taggtctcgc gcggcagtca ctagaggctc atctccgccg aacttcatga ccagcatgaa 9300

gggcacgagc tgcttcccaa aggcccccat ccaagtatag gtctctacat cgtaggtgac 9360

aaagagacgc tcggtgcgag gatgcgagcc gatcgggaag aactggatct cccgccacca 9420

attggaggag tggctattga tgtggtgaaa gtagaagtcc ctgcgacggg ccgaacactc 9480

gtgctggctt ttgtaaaaac gtgcgcagta ctggcagcgg tgcacgggct gtacatcctg 9540

cacgaggttg acctgacgac cgcgcacaag gaagcagagt gggaatttga gcccctcgcc 9600

tggcgggttt ggctggtggt cttctacttc ggctgcttgt ccttgaccgt ctggctgctc 9660

gagggggagtt acggtggatc ggaccaccac gccgcgcgag cccaaagtcc agatgtccgc 9720

gcgcggcggt cggagcttga tgacaacatc gcgcagatgg gagctgtcca tggtctggag 9780

ctcccgcggc gtcaggtcag gcgggagctc ctgcaggttt acctcgcata gacgggtcag 9840

ggcgcgggct agatccaggt gatacctaat ttccaggggc tggttggtgg cggcgtcgat 9900

ggcttgcaag aggccgcatc cccgcggcgc gactacggta ccgcgcggcg ggcggtgggc 9960

cgcggggggtg tccttggatg atgcatctaa aagcggtgac gcgggcgagc ccccggaggt 10020

aggggggggct ccggacccgc cgggagaggg ggcaggggca cgtcggcgcc gcgcgcgggc 10080

aggagctggt gctgcgcgcg taggttgctg gcgaacgcga cgacgcggcg gttgatctcc 10140

tgaatctggc gcctctgcgt gaagacgacg ggcccggtga gcttgaacct gaaagagagt 10200

tcgacagaat caatttcggt gtcgttgacg gcggcctggc gcaaaatctc ctgcacgtct 10260

cctgagttgt cttgataggc gatctcggcc atgaactgct cgatctcttc ctcctggaga 10320

tctccgcgtc cggctcgctc cacggtggcg gcgaggtcgt tggaaatgcg ggccatgagc 10380

tgcgagaagg cgttgaggcc tccctcgttc cagacgcggc tgtagaccac gcccccttcg 10440

gcatcgcggg cgcgcatgac cacctgcgcg agattgagct ccacgtgccg ggcgaagacg 10500

gcgtagtttc gcaggcgctg aaagaggtag ttgagggtgg tggcggtgtg ttctgccacg 10560

aagaagtaca taacccagcg tcgcaacgtg gattcgttga tatcccccaa ggcctcaagg 10620

cgctccatgg cctcgtagaa gtccacggcg aagttgaaaa actgggagtt gcgcgccgac 10680

acggttaact cctcctccag aagacggatg agctcggcga cagtgtcgcg cacctcgcgc 10740

tcaaaggcta caggggcctc ttcttcttct tcaatctcct cttccataag ggcctcccct 10800

tcttcttctt ctggcggcgg tgggggaggg gggacacggc ggcgacgacg gcgcaccggg 10860

aggcggtcga caaagcgctc gatcatctcc ccgcggcgac ggcgcatggt ctcggtgacg 10920

gcgcggccgt tctcgcgggg gcgcagttgg aagacgccgc ccgtcatgtc ccggttatgg 10980

gttggcgggg ggctgccatg cggcagggat acggcgctaa cgatgcatct caacaattgt 11040

tgtgtaggta ctccgccgcc gagggacctg agcgagtccg catcgaccgg atcggaaaac 11100

ctctcgagaa aggcgtctaa ccagtcacag tcgcaaggta ggctgagcac cgtggcgggc 11160

ggcagcgggc ggcggtcggg gttgtttctg gcggaggtgc tgctgatgat gtaattaaag 11220

taggcggtct tgagacggcg gatggtcgac agaagcacca tgtccttggg tccggcctgc 11280

tgaatgcgca ggcggtcggc catgccccag gcttcgtttt gacatcggcg caggtctttg 11340

tagtagtctt gcatgagcct ttctaccggc acttcttctt ctccttcctc ttgtcctgca 11400

tctcttgcat ctatcgctgc ggcggcggcg gagtttggcc gtaggtggcg ccctcttcct 11460

cccatgcgtg tgaccccgaa gcccctcatc ggctgaagca gggctaggtc ggcgacaacg 11520

cgctcggcta atatggcctg ctgcacctgc gtgagggtag actggaagtc atccatgtcc 11580

acaaagcggt ggtatgcgcc cgtgttgatg gtgtaagtgc agttggccat aacggaccag 11640

ttaacggtct ggtgacccgg ctgcgagagc tcggtgtacc tgagacgcga gtaagccctc 11700

gagtcaaata cgtagtcgtt gcaagtccgc accaggtact ggtatcccac caaaaagtgc 11760

ggcggcggct ggcggtagag gggccagcgt agggtggccg gggctccggg ggcgagatct 11820

tccaacataa ggcgatgata tccgtagatg tacctggaca tccaggtgat gccggcggcg 11880

gtggtggagg cgcgcggaaa gtcgcggacg cggttccaga tgttgcgcag cggcaaaaag 11940

tgctccatgg tcgggacgct ctggccggtc aggcgcgcgc aatcgttgac gctctagcgt 12000

gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa ttcgcaaggg 12060

tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt gatccatgcg 12120

gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga gtgctccttt 12180

tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg gccgcgcgca 12240

gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg tagccggagg 12300

gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc ggccggactg 12360

cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt cctccggaaa 12420

cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc agatgcgccc 12480

ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac cctcccctcc 12540

tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg gtgattacga 12600

acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg gcctggcgcg 12660

gctaggagcg ccctctcctg agcggcaccc aagggtgcag ctgaagcgtg atacgcgtga 12720

ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc ccgaggagat 12780

gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt 12840

gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca 12900

cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg agattaactt 12960

tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg 13020

actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata gcaagccgct 13080

catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat tcagggatgc 13140

gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa acatcctgca 13200

gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg ccatcaacta 13260

ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc cttacgttcc 13320

catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga aggtgcttac 13380

cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag 13440

ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg ccctggctgg 13500

cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg acctgcgctg 13560

ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg cggtggcacc 13620

cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg agtacgagcc 13680

agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac 13740

ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac ggacgactgg 13800

cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc gttccggcag 13860

cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac 13920

cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg 13980

cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc 14040

ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag 14100

cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa cgccttcctg 14160

agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt tgtgagcgca 14220

ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg gccagactat 14280

tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc tttcaaaaac 14340

ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg 14400

ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga cagtggcagc 14460

gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc cataggtcag 14520

gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc gctggggcag 14580

gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg gcggcagaag 14640

atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag 14700

agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc 14760

gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg 14820

gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc catcttgaac 14880

ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc cgagggtaac 14940

gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc gcagaccctg 15000

ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg 15060

ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag tagcccattt 15120

ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct gctgggcgag 15180

gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca 15240

tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa gacgtacgcg 15300

caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt 15360

cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt cctggatttg 15420

ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat gttttaaaaa 15480

aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag cgttggtttt 15540

cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct 15600

acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc ttcgatgctc 15660

ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg agaaacagca 15720

tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg gtggacaaca 15780

agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt ctgaccacgg 15840

tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc aatcttgacg 15900

accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg ccaaatgtga 15960

acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta 16020

aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc gagggcaact 16080

actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac tacttgaaag 16140

tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac acccgcaact 16200

tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat acaaacgaag 16260

ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc cacagccgcc 16320

tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt aggatcacct 16380

acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc taccaggcga 16440

gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac agcagtggca 16500

gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg gaggacatga 16560

acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag cgcgctgagg 16620

ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga 16680

agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac aacctaataa 16740

gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac tacggcgacc 16800

ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg 16860

agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc cgctccacgc 16920

gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct 16980

tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct ctgacccacg 17040

tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc accatcacca 17100

ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg cgcaacagca 17160

tcggagggagt ccagcgagtg accattactg acgccagacg ccgcacctgc ccctacgttt 17220

acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca 17280

tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc ccaagcaaga 17340

tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc gggcactacc 17400

gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc gatgacgcca 17460

tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca gtgtccacag 17520

tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac 17580

ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg 17640

cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg cgggccgctc 17700

gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga gcggccgccg 17760

cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg tattgggtgc 17820

gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg 17880

caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg 17940

aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg ccggagatct 18000

atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag cgggtcaaaa 18060

agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg cacgctaccg 18120

cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca 18180

ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg 18240

aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg gagtttgcct 18300

acggaaagcg gcataaggac atgctggcgt tgccgctgga cgaggcaac ccaacaccta 18360

gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc 18420

gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg gtacccaagc 18480

gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg 18540

tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc gtggacgttc 18600

agatacccac taccagtagc accagtattg ccaccgccac agagggcatg gagacacaaa 18660

cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt 18720

ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca gccccccggc 18780

gcccgcgccg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa tatgccctac 18840

atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc agaagacgag 18900

caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt cgccagcccg 18960

tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc 19020

caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt cttgcagata 19080

tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta 19140

ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc 19200

ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt ccactgatcg 19260

ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg cagagacact 19320

gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc 19380

ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct ggccccgcga 19440

cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa tatgagcggt 19500

ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc caccgttaag 19560

aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga taagttgaaa 19620

gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag cggggtggtg 19680

gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc ccgccctccc 19740

gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt 19800

ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc ctcgtacgag 19860

gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc taccggagtg 19920

ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac ccagcagaaa 19980

cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc 20040

cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca 20100

ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg cttctgatag 20160

ctaacgtgtc gtatgtgtgt catgtatgcg tccatgtcgc cgccagagga gctgctgagc 20220

cgccgcgcgc ccgctttcca agatggctac cccttcgatg atgccgcagt ggtcttacat 20280

gcacatctcg ggccaggacg cctcggagta cctgagcccc gggctggtgc agtttgcccg 20340

cgccaccgag acgtacttca gcctgaataa caagtttaga aaccccacgg tggcgcctac 20400

gcacgacgtg accacagacc ggtcccagcg tttgacgctg cggttcatcc ctgtggaccg 20460

tgaggatact gcgtactcgt acaaggcgcg gttcacccta gctgtgggtg ataaccgtgt 20520

gctggacatg gcttccacgt actttgacat ccgcggcgtg ctggacaggg gccctacttt 20580

taagccctac tctggcactg cctacaacgc cctggctccc aagggtgccc caaatccttg 20640

cgaatgggat gaagctgcta ctgctcttga aataaaccta gaagaagagg acgatgacaa 20700

cgaagacgaa gtagacgagc aagctgagca gcaaaaaact cacgtatttg ggcaggcgcc 20760

ttattctggt ataaatatta caaaggaggg tattcaaata ggtgtcgaag gtcaaacacc 20820

taaatatgcc gataaaacat ttcaacctga acctcaaata ggagaatctc agtggtacga 20880

aacagaaatt aatcatgcag ctgggagagt cctaaaaaag actaccccaa tgaaaccatg 20940

ttacggttca tatgcaaaac ccacaaatga aaatggaggg caaggcattc ttgtaaagca 21000

acaaaatgga aagctagaaa gtcaagtgga aatgcaattt ttctcaacta ctgaggcagc 21060

cgcaggcaat ggtgataact tgactcctaa agtggtattg tacagtgaag atgtagatat 21120

agaaacccca gacactcata tttcttacat gcccactatt aaggaaggta actcacgaga 21180

actaatgggc caacaatcta tgcccaacag gcctaattac attgctttta gggacaattt 21240

tattggtcta atgtattaca acagcacggg taatatgggt gttctggcgg gccaagcatc 21300

gcagttgaat gctgttgtag atttgcaaga cagaaacaca gagctttcat accagctttt 21360

gcttgattcc attggtgata gaaccaggta cttttctatg tggaatcagg ctgttgacag 21420

ctatgatcca gatgttagaa ttattgaaaa tcatggaact gaagatgaac ttccaaatta 21480

ctgctttcca ctgggaggtg tgattaatac agagactctt accaaggtaa aacctaaaac 21540

aggtcaggaa aatggatggg aaaaagatgc tacagaattt tcagataaaa atgaaataag 21600

agttggaaat aattttgcca tggaaatcaa tctaaatgcc aacctgtgga gaaatttcct 21660

gtactccaac atagcgctgt atttgcccga caagctaaag tacagtcctt ccaacgtaaa 21720

aatttctgat aacccaaaca cctacgacta catgaacaag cgagtggtgg ctcccgggct 21780

agtggactgc tacattaacc ttggagcacg ctggtccctt gactatatgg acaacgtcaa 21840

cccatttaac caccaccgca atgctggcct gcgctaccgc tcaatgttgc tgggcaatgg 21900

tcgctatgtg cccttccaca tccaggtgcc tcagaagttc tttgccatta aaaacctcct 21960

tctcctgccg ggctcataca cctacgagtg gaacttcagg aaggatgtta acatggttct 22020

gcagagctcc ctaggaaatg acctaagggt tgacggagcc agcattaagt ttgatagcat 22080

ttgcctttac gccaccttct tccccatggc ccacaacacc gcctccacgc ttgaggccat 22140

gcttagaaac gacaccaacg accagtcctt taacgactat ctctccgccg ccaacatgct 22200

ctaccctata cccgccaacg ctaccaacgt gcccatatcc atcccctccc gcaactgggc 22260

ggctttccgc ggctgggcct tcacgcgcct taagactaag gaaaccccat cactgggctc 22320

gggctacgac ccttattaca cctactctgg ctctataccc tacctagatg gaacctttta 22380

cctcaaccac acctttaaga aggtggccat tacctttgac tcttctgtca gctggcctgg 22440

caatgaccgc ctgcttaccc ccaacgagtt tgaaattaag cgctcagttg acggggaggg 22500

ttacaacgtt gcccagtgta acatgaccaa agactggttc ctggtacaaa tgctagctaa 22560

ctataacatt ggctaccagg gcttctatat cccagagagc tacaaggacc gcatgtactc 22620

cttctttaga aacttccagc ccatgagccg tcaggtggtg gatgatacta aatacaagga 22680

ctaccaacag gtgggcatcc tacaccaaca caacaactct ggatttgttg gctaccttgc 22740

ccccaccatg cgcgaaggac aggcctaccc tgctaacttc ccctatccgc ttataggcaa 22800

gaccgcagtt gacagcatta cccagaaaaa gtttctttgc gatcgcaccc tttggcgcat 22860

cccattctcc agtaacttta tgtccatggg cgcactcaca gacctgggcc aaaaccttct 22920

ctacgccaac tccgcccacg cgctagacat gacttttgag gtggatccca tggacgagcc 22980

cacccttctt tatgttttgt ttgaagtctt tgacgtggtc cgtgtgcacc agccgcaccg 23040

cggcgtcatc gaaaccgtgt acctgcgcac gcccttctcg gccggcaacg ccacaacata 23100

aagaagcaag caacatcaac aacagctgcc gccatgggct ccagtgagca ggaactgaaa 23160

gccattgtca aagatcttgg ttgtggggcca tattttttgg gcacctatga caagcgcttt 23220

ccaggctttg tttctccaca caagctcgcc tgcgccatag tcaatacggc cggtcgcgag 23280

actgggggcg tacactggat ggcctttgcc tggaacccgc actcaaaaac atgctacctc 23340

tttgagccct ttggcttttc tgaccagcga ctcaagcagg tttaccagtt tgagtacgag 23400

tcactcctgc gccgtagcgc cattgcttct tcccccgacc gctgtataac gctggaaaag 23460

tccacccaaa gcgtacaggg gcccaactcg gccgcctgtg gactattctg ctgcatgttt 23520

ctccacgcct ttgccaactg gccccaaact cccatggatc acaaccccac catgaacctt 23580

attaccgggg tacccaactc catgctcaac agtccccagg tacagcccac cctgcgtcgc 23640

aaccaggaac agctctacag cttcctggag cgccactcgc cctacttccg cagccacagt 23700

gcgcagatta ggagcgccac ttctttttgt cacttgaaaa acatgtaaaa ataatgtact 23760

agagacactt tcaataaagg caaatgcttt tatttgtaca ctctcgggtg attatttacc 23820

cccacccttg ccgtctgcgc cgtttaaaaa tcaaaggggt tctgccgcgc atcgctatgc 23880

gccactggca gggacacgtt gcgatactgg tgtttagtgc tccacttaaa ctcaggcaca 23940

accatccgcg gcagctcggt gaagttttca ctccacaggc tgcgcaccat caccaacgcg 24000

tttagcaggt cgggcgccga tatcttgaag tcgcagttgg ggcctccgcc ctgcgcgcgc 24060

gagttgcgat acacagggtt gcagcactgg aacactatca gcgccgggtg gtgcacgctg 24120

gccagcacgc tcttgtcgga gatcagatcc gcgtccaggt cctccgcgtt gctcagggcg 24180

aacggagtca actttggtag ctgccttccc aaaaagggcg cgtgcccagg ctttgagttg 24240

cactcgcacc gtagtggcat caaaaggtga ccgtgcccgg tctgggcgtt aggatacagc 24300

gcctgcataa aagccttgat ctgcttaaaa gccacctgag cctttgcgcc ttcagagaag 24360

aacatgccgc aagacttgcc ggaaaactga ttggccggac aggccgcgtc gtgcacgcag 24420

caccttgcgt cggtgttgga gatctgcacc acatttcggc cccaccggtt cttcacgatc 24480

ttggccttgc tagactgctc cttcagcgcg cgctgcccgt tttcgctcgt cacatccatt 24540

tcaatcacgt gctccttatt tatcataatg cttccgtgta gacacttaag ctcgccttcg 24600

atctcagcgc agcggtgcag ccacaacgcg cagcccgtgg gctcgtgatg cttgtaggtc 24660

acctctgcaa acgactgcag gtacgcctgc aggaatcgcc ccatcatcgt cacaaaggtc 24720

ttgttgctgg tgaaggtcag ctgcaacccg cggtgctcct cgttcagcca ggtcttgcat 24780

acggccgcca gagcttccac ttggtcaggc agtagtttga agttcgcctt tagatcgtta 24840

tccacgtggt acttgtccat cagcgcgcgc gcagcctcca tgcccttctc ccacgcagac 24900

acgatcggca cactcagcgg gttcatcacc gtaatttcac tttccgcttc gctgggctct 24960

tcctcttcct cttgcgtccg cataccacgc gccactgggt cgtcttcatt cagccgccgc 25020

actgtgcgct tacctccttt gccatgcttg attagcaccg gtgggttgct gaaacccacc 25080

atttgtagcg ccacatcttc tctttcttcc tcgctgtcca cgattacctc tggtgatggc 25140

gggcgctcgg gcttgggaga agggcgcttc tttttcttct tgggcgcaat ggccaaatcc 25200

gccgccgagg tcgatggccg cgggctgggt gtgcgcggca ccagcgcgtc ttgtgatgag 25260

tcttcctcgt cctcggactc gatacgccgc ctcatccgct tttttggggg cgcccgggga 25320

ggcggcggcg acggggacgg ggacgacacg tcctccatgg ttgggggacg tcgcgccgca 25380

ccgcgtccgc gctcggggggt ggtttcgcgc tgctcctctt cccgactggc catttccttc 25440

tcctataggc agaaaaagat catggagtca gtcgagaaga aggacagcct aaccgccccc 25500

tctgagttcg ccaccaccgc ctccaccgat gccgccaacg cgcctaccac cttccccgtc 25560

gaggcacccc cgcttgagga ggaggaagtg attatcgagc aggacccagg ttttgtaagc 25620

gaagacgacg aggaccgctc agtaccaaca gaggataaaa agcaagacca ggacaacgca 25680

gaggcaaacg aggaacaagt cgggcggggg gacgaaaggc atggcgacta cctagatgtg 25740

ggagacgacg tgctgttgaa gcatctgcag cgccagtgcg ccattatctg cgacgcgttg 25800

caagagcgca gcgatgtgcc cctcgccata gcggatgtca gccttgccta cgaacgccac 25860

ctattctcac cgcgcgtacc ccccaaacgc caagaaaacg gcacatgcga gcccaacccg 25920

cgcctcaact tctaccccgt atttgccgtg ccagaggtgc ttgccaccta tcacatcttt 25980

ttccaaaact gcaagatacc cctatcctgc cgtgccaacc gcagccgagc ggacaagcag 26040

ctggccttgc ggcagggcgc tgtcatacct gatatcgcct cgctcaacga agtgccaaaa 26100

atctttgagg gtcttggacg cgacgagaag cgcgcggcaa acgctctgca acaggaaaac 26160

agcgaaaatg aaagtcactc tggagtgttg gtggaactcg agggtgacaa cgcgcgccta 26220

gccgtactaa aacgcagcat cgaggtcacc cactttgcct acccggcact taacctaccc 26280

cccaaggtca tgagcacagt catgagtgag ctgatcgtgc gccgtgcgca gcccctggag 26340

agggatgcaa atttgcaaga acaaacagag gagggcctac ccgcagttgg cgacgagcag 26400

ctagcgcgct ggcttcaaac gcgcgagcct gccgacttgg aggagcgacg caaactaatg 26460

atggccgcag tgctcgttac cgtggagctt gagtgcatgc agcggttctt tgctgacccg 26520

gagatgcagc gcaagctaga ggaaacattg cactacacct ttcgacaggg ctacgtacgc 26580

caggcctgca agatctccaa cgtggagctc tgcaacctgg tctcctacct tggaattttg 26640

cacgaaaacc gccttgggca aaacgtgctt cattccacgc tcaagggcga ggcgcgccgc 26700

gactacgtcc gcgactgcgt ttacttattt ctatgctaca cctggcagac ggccatgggc 26760

gtttggcagc agtgcttgga ggagtgcaac ctcaaggagc tgcagaaact gctaaagcaa 26820

aacttgaagg acctatggac ggccttcaac gagcgctccg tggccgcgca cctggcggac 26880

atcattttcc ccgaacgcct gcttaaaacc ctgcaacagg gtctgccaga cttcaccagt 26940

caaagcatgt tgcagaactt taggaacttt atcctagagc gctcaggaat cttgcccgcc 27000

acctgctgtg cacttcctag cgactttgtg cccattaagt accgcgaatg ccctccgccg 27060

ctttggggcc actgctacct tctgcagcta gccaactacc ttgcctacca ctctgacata 27120

atggaagacg tgagcggtga cggtctactg gagtgtcact gtcgctgcaa cctatgcacc 27180

ccgcaccgct ccctggtttg caattcgcag ctgcttaacg aaagtcaaat tatcggtacc 27240

tttgagctgc agggtccctc gcctgacgaa aagtccgcgg ctccggggtt gaaactcact 27300

ccggggctgt ggacgtcggc ttaccttcgc aaatttgtac ctgaggacta ccacgcccac 27360

gagattaggt tctacgaaga ccaatcccgc ccgcctaatg cggagcttac cgcctgcgtc 27420

attacccagg gccacattct tggccaattg caagccatca acaaagcccg ccaagagttt 27480

ctgctacgaa agggacgggg ggtttacttg gacccccagt ccggcgagga gctcaaccca 27540

atccccccgc cgccgcagcc ctatcagcag cagccgcggg cccttgcttc ccaggatggc 27600

acccaaaaag aagctgcagc tgccgccgcc acccacggac gagggaggaat actgggacag 27660

tcaggcagag gaggttttgg acgaggagga ggaggacatg atggaagact gggagagcct 27720

agacgaggaa gcttccgagg tcgaagaggt gtcagacgaa acaccgtcac cctcggtcgc 27780

attcccctcg ccggcgcccc agaaatcggc aaccggttcc agcatggcta caacctccgc 27840

tcctcaggcg ccgccggcac tgcccgttcg ccgacccaac cgtagatggg acaccactgg 27900

aaccagggcc ggtaagtcca agcagccgcc gccgttagcc caagagcaac aacagcgcca 27960

aggctaccgc tcatggcgcg ggcacaagaa cgccatagtt gcttgcttgc aagactgtgg 28020

gggcaacatc tccttcgccc gccgctttct tctctaccat cacggcgtgg ccttcccccg 28080

taacatcctg cattactacc gtcatctcta cagcccatac tgcaccggcg gcagcggcag 28140

caacagcagc ggccacacag aagcaaaggc gaccggatag caagactctg acaaagccca 28200

agaaatccac agcggcggca gcagcaggag gaggagcgct gcgtctggcg cccaacgaac 28260

ccgtatcgac ccgcgagctt agaaacagga tttttcccac tctgtatgct atatttcaac 28320

agagcagggg ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga tccctcaccc 28380

gcagctgcct gtatcacaaa agcgaagatc agcttcggcg cacgctggaa gacgcggagg 28440

ctctcttcag taaatactgc gcgctgactc ttaaggacta gtttcgcgcc ctttctcaaa 28500

tttaagcgcg aaaactacgt catctccagc ggccacaccc ggcgccagca cctgttgtca 28560

gcgccattat gagcaaggaa attcccacgc cctacatgtg gagttaccag ccacaaatgg 28620

gacttgcggc tggagctgcc caagactact caacccgaat aaactacatg agcgcgggac 28680

cccacatgat atcccgggtc aacggaatac gcgcccaccg aaaccgaatt ctcctggaac 28740

aggcggctat taccaccaca cctcgtaata accttaatcc ccgtagttgg cccgctgccc 28800

tggtgtacca ggaaagtccc gctcccacca ctgtggtact tcccagagac gcccaggccg 28860

aagttcagat gactaactca ggggcgcagc ttgcgggcgg ctttcgtcac agggtgcggt 28920

cgcccgggca gggtataact cacctgacaa tcagagggcg aggtattcag ctcaacgacg 28980

agtcggtgag ctcctcgctt ggtctccgtc cggacgggac atttcagatc ggcggcgccg 29040

gccgctcttc attcacgcct cgtcaggcaa tcctaactct gcagacctcg tcctctgagc 29100

cgcgctctgg aggcattgga actctgcaat ttattgagga gtttgtgcca tcggtctact 29160

ttaacccctt ctcgggacct cccggccact atccggatca atttattcct aactttgacg 29220

cggtaaagga ctcggcggac ggctacgact gaatgttaag tggagaggca gagcaactgc 29280

gcctgaaaca cctggtccac tgtcgccgcc acaagtgctt tgcccgcgac tccggtgagt 29340

tttgctactt tgaattgccc gaggatcata tcgagggccc ggcgcacggc gtccggctta 29400

ccgcccaggg agagcttgcc cgtagcctga ttcgggagtt tacccagcgc cccctgctag 29460

ttgagcggga caggggaccc tgtgttctca ctgtgatttg caactgtcct aaccctggat 29520

tacatcaaga tcctctagtt aatgtcaggt cgcctaagtc gattaactag agtacccggg 29580

gatcttattc cctttaacta ataaaaaaaa ataataaagc atcacttact taaaatcagt 29640

tagcaaattt ctgtccagtt tattcagcag cacctccttg ccctcctccc agctctggta 29700

ttgcagcttc ctcctggctg caaactttct ccacaatcta aatggaatgt cagtttcctc 29760

ctgttcctgt ccatccgcac ccactatctt catgttgttg cagatgaagc gcgcaagacc 29820

gtctgaagat accttcaacc ccgtgtatcc atatgacacg gaaaccggtc ctccaactgt 29880

gccttttctt actcctccct ttgtatcccc caatgggttt caagagagtc cccctggggt 29940

actctctttg cgcctatccg aacctctagt tacctccaat ggcatgcttg cgctcaaaat 30000

gggcaacggc ctctctctgg acgaggccgg caaccttacc tcccaaaatg taaccactgt 30060

gagcccacct ctcaaaaaaa ccaagtcaaa cataaacctg gaaatatctg cacccctcac 30120

agttacctca gaagccctaa ctgtggctgc cgccgcacct ctaatggtcg cgggcaacac 30180

actcaccatg caatcacagg ccccgctaac cgtgcacgac tccaaactta gcattgccac 30240

ccaaggaccc ctcacagtgt cagaaggaaa gctagccctg caaacatcag gccccctcac 30300

caccaccgat agcagtaccc ttactatcac tgcctcaccc cctctaacta ctgccactgg 30360

tagcttgggc attgacttga aagagcccat ttatacacaa aatggaaaac taggactaaa 30420

gtacggggct cctttgcatg taacagacga cctaaacact ttgaccgtag caactggtcc 30480

aggtgtgact attaataata cttccttgca aactaaagtt actggagcct tgggttttga 30540

ttcacaaggc aatatgcaac ttaatgtagc aggaggacta aggattgatt ctcaaaacag 30600

acgccttata cttgatgtta gttatccgtt tgatgctcaa aaccaactaa atctaagact 30660

aggacagggc cctcttttta taaactcagc ccacaacttg gatattaact acaacaaagg 30720

cctttacttg tttacagctt caaacaattc caaaaagctt gaggttaacc taagcactgc 30780

caaggggttg atgtttgacg ctacagccat agccattaat gcaggagatg ggcttgaatt 30840

tggttcacct aatgcaccaa acacaaatcc cctcaaaaca aaaattggcc atggcctaga 30900

atttgattca aacaaggcta tggttcctaa actaggaact ggccttagtt ttgacagcac 30960

aggtgccatt acagtaggaa acaaaaataa tgataagcta actttgtgga ccggaataaa 31020

ccctccacct aactgtcaaa ttgtggaaaa cactaataca aatgatggca aacttacttt 31080

agtattagta aaaaatggag ggcttgttaa tggctacgtg tctctagttg gtgtatcaga 31140

cactgtgaac caaatgttca cacaaaagac agcaaacatc caattaagat tatattttga 31200

ctcttctgga aatctattaa ctgaggaatc agacttaaaa attccactta aaaataaatc 31260

ttctacagcg accagtgaaa ctgtagccag cagcaaagcc tttatgccaa gtactacagc 31320

ttatcccttc aacaccacta ctagggatag tgaaaactac attcatggaa tatgttacta 31380

catgactagt tatgatagaa gtctatttcc cttgaacatt tctataatgc taaacagccg 31440

tatgatttct tccaatgttg cctatgccat acaatttgaa tggaatctaa atgcaagtga 31500

atctccagaa agcaacatag ctacgctgac cacatccccc tttttctttt cttacattac 31560

agaagacgac aactaaagaa tcgtttgtgt tatgtttcaa cgtgtttatt tttcaattgc 31620

agaaaatttc aagtcatttt tcattcagta gtatagcccc accaccacat agcttataca 31680

gatcaccgta ccttaatcaa actcacagaa ccctagtatt caacctgcca cctccctccc 31740

aacacacaga gtacacagtc ctttctcccc ggctggcctt aaaaagcatc atatcatggg 31800

taacagacat attcttaggt gttatattcc acacggtttc ctgtcgagcc aaacgctcat 31860

cagtgatatt aataaactcc ccgggcagct cacttaagtt catgtcgctg tccagctgct 31920

gagccacagg ctgctgtcca acttgcggtt gcttaacggg cggcgaagga gaagtccacg 31980

cctacatggg ggtagagtca taatcgtgca tcaggatagg gcggtggtgc tgcagcagcg 32040

cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga atacaacatg gcagtggtct 32100

cctcagcgat gattcgcacc gcccgcagca taaggcgcct tgtcctccgg gcacagcagc 32160

gcaccctgat ctcacttaaa tcagcacagt aactgcagca cagcaccaca atattgttca 32220

aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc ggggaccaca gaacccacgt 32280

ggccatcata ccacaagcgc aggtagatta agtggcgacc cctcataaac acgctggaca 32340

taaacattac ctcttttggc atgttgtaat tcaccacctc ccggtaccat ataaacctct 32400

gattaaacat ggcgccatcc accaccatcc taaaccagct ggccaaaacc tgcccgccgg 32460

ctatacactg cagggaaccg ggactggaac aatgacagtg gagagcccag gactcgtaac 32520

catggatcat catgctcgtc atgatatcaa tgttggcaca acacaggcac acgtgcatac 32580

acttcctcag gattacaagc tcctcccgcg ttagaaccat atcccaggga acaacccatt 32640

cctgaatcag cgtaaatccc acactgcagg gaagacctcg cacgtaactc acgttgtgca 32700

ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc cagtatggta gcgcgggttt 32760

ctgtctcaaa aggaggtaga cgatccctac tgtacggagt gcgccgagac aaccgagatc 32820

gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt agtcatattt cctgaagcaa 32880

aaccaggtgc gggcgtgaca aacagatctg cgtctccggt ctcgccgctt agatcgctct 32940

gtgtagtagt tgtagtatat ccactctctc aaagcatcca ggcgccccct ggcttcgggt 33000

tctatgtaaa ctccttcatg cgccgctgcc ctgataacat ccaccaccgc agaataagcc 33060

acacccagcc aacctacaca ttcgttctgc gagtcacaca cgggaggagc gggaagagct 33120

ggaagaacca tgtttttttt tttattccaa aagattatcc aaaacctcaa aatgaagatc 33180

tattaagtga acgcgctccc ctccggtggc gtggtcaaac tctacagcca aagaacagat 33240

aatggcattt gtaagatgtt gcacaatggc ttccaaaagg caaacggccc tcacgtccaa 33300

gtggacgtaa aggctaaacc cttcagggtg aatctcctct ataaacattc cagcaccttc 33360

aaccatgccc aaataattct catctcgcca ccttctcaat atatctctaa gcaaatcccg 33420

aatattaagt ccggccattg taaaaatctg ctccagagcg ccctccacct tcagcctcaa 33480

gcagcgaatc atgattgcaa aaattcaggt tcctcacaga cctgtataag attcaaaagc 33540

ggaacattaa caaaaatacc gcgatcccgt aggtcccttc gcagggccag ctgaacataa 33600

tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc caggaaccat gacaaaagaa 33660

cccacactga ttatgacacg catactcgga gctatgctaa ccagcgtagc cccgatgtaa 33720

gcttgttgca tgggcggcga tataaaatgc aaggtgctgc tcaaaaaatc aggcaaagcc 33780

tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca gataaaggca ggtaagctcc 33840

ggaaccacca cagaaaaaga caccattttt ctctcaaaca tgtctgcggg tttctgcata 33900

aacacaaaat aaaataacaa aaaaacattt aaacattaga agcctgtctt acaacaggaa 33960

aaacaaccct tataagcata agacggacta cggccatgcc ggcgtgaccg taaaaaaact 34020

ggtcaccgtg attaaaaagc accaccgaca gctcctcggt catgtccgga gtcataatgt 34080

aagactcggt aaacacatca ggttgattca catcggtcag tgctaaaaag cgaccgaaat 34140

agcccggggg aatacatacc cgcaggcgta gagacaacat tacagccccc ataggaggta 34200

taacaaaatt aataggagag aaaaacacat aaacacctga aaaaccctcc tgcctaggca 34260

aaatagcacc ctcccgctcc agaacaacat acagcgcttc cacagcggca gccataacag 34320

tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca ccactcgaca cggcaccagc 34380

tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg agtatatata ggactaaaaa 34440

atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa ccgcacgcga acctacgccc 34500

agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt cacttccgtt ttcccacgtt 34560

acgtcacttc ccattttaag aaaactacaa ttcccaacac atacaagtta ctccgcccta 34620

aaacctacgt cacccgcccc gttcccacgc cccgcgccac gtcacaaact ccaccccctc 34680

attatcatat tggcttcaat ccaaaataag gtatattatt gatgatg 34727

<210> 26

<211> 37675

<212> DNA

<213> Artificial sequence

<220>

<223> plasmid vector #3

<400> 26

ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag 180

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa 780

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt 1020

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc 1200

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320

ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tactgggcta 1440

tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500

ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560

cgccctctgg taaggttggg aagccctgca aagtaaactg gatggctttc ttgccgccaa 1620

ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860

aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc 2040

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg 2460

acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520

gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640

aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt 2880

aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940

atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000

tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060

atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120

tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180

aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240

gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 3300

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta 3600

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccatg 3720

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780

actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca 3840

gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt cgacgagctc 3900

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa 3960

gacaccggga ccgatccagc ctccgatttg ccaccatgtt tgtgttcctg gtgctgctgc 4020

cactggtgtc cagccagtgt gtgaacctga ccaccaggac ccaacttcct cctgcctaca 4080

ccaactcctt caccagggga gtctactacc ctgacaaggt gttcaggtcc tctgtgctgc 4140

acagcaccca ggacctgttc ctgccattct tcagcaatgt gacctggttc catgccatcc 4200

atgtgtctgg caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg 4260

gagtctactt tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca 4320

ccctggacag caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta 4380

aggtgtgtga gttccagttc tgtaatgacc cattcctggg agtctactac cacaagaaca 4440

acaagtcctg gatggagtct gagttcaggg tctactcctc tgccaacaac tgtacctttg 4500

aatatgtgag ccaaccattc ctgatggact tggagggcaa gcagggcaac ttcaagaacc 4560

tgagggagtt tgtgttcaag aacattgatg gctacttcaa gatttacagc aaacacacac 4620

caatcaacct ggtgagggac ctgccacagg gcttctctgc cttggaacca ctggtggacc 4680

tgccaattgg catcaacatc accaggttcc agaccctgct ggctctgcac aggtcctacc 4740

tgacacctgg agactcctcc tctggctgga cagcaggagc agcagcctac tatgtgggct 4800

acctccaacc aaggaccttc ctgctgaaat acaatgagaa tggcaccatc acagatgctg 4860

tggactgtgc cctggaccca ctgtctgaga ccaagtgtac cctgaaatcc ttcacagtgg 4920

agaagggcat ctaccagacc agcaacttca gggtccaacc aacagagagc attgtgaggt 4980

ttccaaacat caccaacctg tgtccattg gagaggtgtt caatgccacc aggtttgcct 5040

ctgtctatgc ctggaacagg aagaggatta gcaactgtgt ggctgactac tctgtgctct 5100

acaactctgc ctccttcagc accttcaagt gttatggagt gagcccaacc aaactgaatg 5160

acctgtgttt caccaatgtc tatgctgact cctttgtgat taggggagat gaggtgagac 5220

agattgcccc tggacaaaca ggcaagattg ctgactacaa ctacaaactg cctgatgact 5280

tcacaggctg tgtgattgcc tggaacagca acaacctgga cagcaaggtg ggaggcaact 5340

acaactacct ctacagactg ttcaggaaga gcaacctgaa accatttgag agggacatca 5400

gcacagagat ttaccaggct ggcagcacac catgtaatgg agtggagggc ttcaactgtt 5460

actttccact ccaatcctat ggcttccaac caaccaatgg agtgggctac caaccataca 5520

gggtggtggt gctgtccttt gaactgctcc atgcccctgc cacagtgtgt ggaccaaaga 5580

agagcaccaa cctggtgaag aacaagtgtg tgaacttcaa cttcaatgga ctgacaggca 5640

caggagtgct gacagagagc aacaagaagt tcctgccatt ccaacagttt ggcagggaca 5700

ttgctgacac cacagatgct gtgagggacc cacagacctt ggagattctg gacatcacac 5760

catgttcctt tggagagtg tctgtgatta cacctggcac caacaccagc aaccaggtgg 5820

ctgtgctcta ccaggatgtg aactgtactg aggtgcctgt ggctatccat gctgaccaac 5880

ttacaccaac ctggagggtc tacagcacag gcagcaatgt gttccagacc agggctggct 5940

gtctgattgg agcagagcat gtgaacaact cctatgagtg tgacatccca attggagcag 6000

gcatctgtgc ctcctaccag acccagaccg gtggcggtgg gtcgaggtct gtggcaagcc 6060

agagcatcat tgcctacaca atgagtctgg gagcagagaa ctctgtggct tacagcaaca 6120

acagcattgc catcccaacc aacttcacca tctctgtgac cacagagatt ctgcctgtga 6180

gtatgaccaa gacctctgtg gactgtacaa tgtatatctg tggagacagc acagagtgta 6240

gcaacctgct gctccaatat ggctccttct gtacccaact taacagggct ctgacaggca 6300

ttgctgtgga acaggacaag aacacccagg aggtgtttgc ccaggtgaag cagatttaca 6360

agacacctcc aatcaaggac tttggaggct tcaacttcag ccagattctg cctgacccaa 6420

gcaagccaag caagaggtcc ttcattgagg acctgctgtt caacaaggtg accctggctg 6480

atgctggctt catcaagcaa tatggagact gtctgggaga cattgctgcc agggacctga 6540

tttgtgccca gaagttcaat ggactgacag tgctgcctcc actgctgaca gatgagatga 6600

ttgcccaata cacctctgcc ctgctggctg gcaccatcac ctctggctgg acctttggag 6660

caggagcagc cctccaaatc ccatttgcta tgcagatggc ttacaggttc aatggcattg 6720

gagtgaccca gaatgtgctc tatgagaacc agaaactgat tgccaaccag ttcaactctg 6780

ccattggcaa gattcaggac tccctgtcca gcacagcctc tgccctgggc aaactccaag 6840

atgtggtgaa ccagaatgcc caggctctga acaccctggt gaagcaactt tccagcaact 6900

ttggagccat ctcctctgtg ctgaatgaca tcctgagcag actggacaag gtggaggctg 6960

aggtccagat tgacagactg attacaggca gactccaatc cctccaaacc tatgtgaccc 7020

aacaacttat cagggctgct gagattaggg catctgccaa cctggctgcc accaagatga 7080

gtgagtgtgt gctgggacaa agcaagagg tggacttctg tggcaagggc taccacctga 7140

tgagttttcc acagtctgcc cctcatggag tggtgttcct gcatgtgacc tatgtgcctg 7200

cccaggagaa gaacttcacc acagcccctg ccatctgcca tgatggcaag gctcactttc 7260

caagggaggg agtgtttgtg agcaatggca cccactggtt tgtgacccag aggaacttct 7320

atgaaccaca gattatcacc acagacaaca cctttgtgtc tggcaactgt gatgtggtga 7380

ttggcattgt gaacaacaca gtctatgacc cactccaacc tgaactggac tccttcaagg 7440

aggaactgga caaatacttc aagaaccaca ccagccctga tgtggacctg ggagacatct 7500

ctggcatcaa tgcctctgtg gtgaacatcc agaaggagat tgacagactg aatgaggtgg 7560

ctaagaacct gaatgagtcc ctgattgacc tccaagaact gggcaaatat gaacaataca 7620

tcaagtggcc atgaaaattg atcataatca gccataccac atttgtagag gttttacttg 7680

ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 7740

ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 7800

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg 7860

tatcttaacg cggatctggg cgtggttaag ggtgggaaag aatatataag gtggggggtct 7920

tatgtagttt tgtatctgtt ttgcagcagc cgccgccgcc atgagcacca actcgtttga 7980

tggaagcatt gtgagctcat atttgacaac gcgcatgccc ccatgggccg gggtgcgtca 8040

gaatgtgatg ggctccagca ttgatggtcg ccccgtcctg cccgcaaact ctactacctt 8100

gacctacgag accgtgtctg gaacgccgtt ggagactgca gcctccgccg ccgcttcagc 8160

cgctgcagcc accgcccgcg ggattgtgac tgactttgct ttcctgagcc cgcttgcaag 8220

cagtgcagct tcccgttcat ccgcccgcga tgacaagttg acggctcttt tggcacaatt 8280

ggattctttg acccgggaac ttaatgtcgt ttctcagcag ctgttggatc tgcgccagca 8340

ggtttctgcc ctgaaggctt cctcccctcc caatgcggtt taaaacataa ataaaaaacc 8400

agactctgtt tggatttgga tcaagcaagt gtcttgctgt ctttatttag gggttttgcg 8460

cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 8520

gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 8580

gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 8640

gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 8700

caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 8760

tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 8820

gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 8880

atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 8940

ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 9000

atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 9060

tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 9120

gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 9180

tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 9240

caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 9300

cggctgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 9360

ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 9420

gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 9480

cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 9540

cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 9600

tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 9660

cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 9720

ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 9780

tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 9840

cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 9900

agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 9960

gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 10020

accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 10080

ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 10140

tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 10200

cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 10260

gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 10320

attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 10380

gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 10440

ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 10500

aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgaggt ggccgcatcc 10560

atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 10620

gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 10680

tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 10740

acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 10800

aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 10860

cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 10920

tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 10980

aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 11040

ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 11100

tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 11160

gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 11220

cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 11280

atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 11340

aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 11400

gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 11460

agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 11520

tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 11580

catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 11640

agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 11700

catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 11760

gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 11820

cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 11880

tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 11940

atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 12000

tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 12060

cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 12120

ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 12180

ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 12240

agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 12300

taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 12360

cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 12420

gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 12480

acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 12540

ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 12600

ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 12660

atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 12720

gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 12780

cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 12840

gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 12900

cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 12960

ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 13020

gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 13080

tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgaacctga 13140

aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 13200

gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 13260

cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 13320

ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 13380

ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 13440

cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 13500

ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 13560

cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 13620

gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 13680

cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 13740

cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 13800

gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 13860

cggtgacggc gcggccgttc tcgcggggggc gcagttggaa gacgccgccc gtcatgtccc 13920

ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 13980

acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 14040

cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 14100

tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 14160

aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 14220

cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 14280

ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 14340

gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 14400

ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 14460

cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 14520

ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 14580

cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 14640

aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 14700

aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 14760

cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 14820

cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 14880

gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 14940

tctagcgtgc aaaaggagag cctgtaagcg ggcactcttc cgtggtctgg tggataaatt 15000

cgcaagggta tcatggcgga cgaccggggt tcgagccccg tatccggccg tccgccgtga 15060

tccatgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca acgggggagt 15120

gctccttttg gcttccttcc aggcgcggcg gctgctgcgc tagctttttt ggccactggc 15180

cgcgcgcagc gtaagcggtt aggctggaaa gcgaaagcat taagtggctc gctccctgta 15240

gccggagggt tattttccaa gggttgagtc gcgggacccc cggttcgagt ctcggaccgg 15300

ccggactgcg gcgaacgggg gtttgcctcc ccgtcatgca agaccccgct tgcaaattcc 15360

tccggaaaca gggacgagcc ccttttttgc ttttcccaga tgcatccggt gctgcggcag 15420

atgcgccccc ctcctcagca gcggcaagag caagagcagc ggcagacatg cagggcaccc 15480

tcccctcctc ctaccgcgtc aggaggggcg acatccgcgg ttgacgcggc agcagatggt 15540

gattacgaac ccccgcggcg ccgggcccgg cactacctgg acttggagga gggcgagggc 15600

ctggcgcggc taggagcgcc ctctcctgag cggcacccaa gggtgcagct gaagcgtgat 15660

acgcgtgagg cgtacgtgcc gcggcagaac ctgtttcgcg accgcgaggg agaggagccc 15720

gaggagatgc gggatcgaaa gttccacgca gggcgcgagc tgcggcatgg cctgaatcgc 15780

gagcggttgc tgcgcgagga ggactttgag cccgacgcgc gaaccgggat tagtcccgcg 15840

cgcgcacacg tggcggccgc cgacctggta accgcatacg agcagacggt gaaccaggag 15900

attaactttc aaaaaagctt taacaaccac gtgcgtacgc ttgtggcgcg cgaggaggtg 15960

gctataggac tgatgcatct gtgggacttt gtaagcgcgc tggagcaaaa cccaaatagc 16020

aagccgctca tggcgcagct gttccttata gtgcagcaca gcagggacaa cgaggcattc 16080

agggatgcgc tgctaaacat agtagagccc gagggccgct ggctgctcga tttgataaac 16140

atcctgcaga gcatagtggt gcaggagcgc agcttgagcc tggctgacaa ggtggccgcc 16200

atcaactatt ccatgcttag cctgggcaag ttttacgccc gcaagatata ccatacccct 16260

tacgttccca tagacaagga ggtaaagatc gaggggttct acatgcgcat ggcgctgaag 16320

gtgcttacct tgagcgacga cctgggcgtt tatcgcaacg agcgcatcca caaggccgtg 16380

agcgtgagcc ggcggcgcga gctcagcgac cgcgagctga tgcacagcct gcaaagggcc 16440

ctggctggca cgggcagcgg cgatagagag gccgagtcct actttgacgc gggcgctgac 16500

ctgcgctggg ccccaagccg acgcgccctg gaggcagctg gggccggacc tgggctggcg 16560

gtggcacccg cgcgcgctgg caacgtcggc ggcgtggagg aatatgacga ggacgatgag 16620

tacgagccag aggacggcga gtactaagcg gtgatgtttc tgatcagatg atgcaagacg 16680

caacggaccc ggcggtgcgg gcggcgctgc agagccagcc gtccggcctt aactccacgg 16740

acgactggcg ccaggtcatg gaccgcatca tgtcgctgac tgcgcgcaat cctgacgcgt 16800

tccggcagca gccgcaggcc aaccggctct ccgcaattct ggaagcggtg gtcccggcgc 16860

gcgcaaaccc cacgcacgag aaggtgctgg cgatcgtaaa cgcgctggcc gaaaacaggg 16920

ccatccggcc cgacgaggcc ggcctggtct acgacgcgct gcttcagcgc gtggctcgtt 16980

acaacagcgg caacgtgcag accaacctgg accggctggt gggggatgtg cgcgaggccg 17040

tggcgcagcg tgagcgcgcg cagcagcagg gcaacctggg ctccatggtt gcactaaacg 17100

ccttcctgag tacacagccc gccaacgtgc cgcggggaca ggaggactac accaactttg 17160

tgagcgcact gcggctaatg gtgactgaga caccgcaaag tgaggtgtac cagtctgggc 17220

cagactattt tttccagacc agtagacaag gcctgcagac cgtaaacctg agccaggctt 17280

tcaaaaactt gcaggggctg tggggggtgc gggctcccac aggcgaccgc gcgaccgtgt 17340

ctagcttgct gacgcccaac tcgcgcctgt tgctgctgct aatagcgccc ttcacggaca 17400

gtggcagcgt gtcccgggac acatacctag gtcacttgct gacactgtac cgcgaggcca 17460

taggtcaggc gcatgtggac gagcatactt tccaggagat tacaagtgtc agccgcgcgc 17520

tggggcagga ggacacgggc agcctggagg caaccctaaa ctacctgctg accaaccggc 17580

ggcagaagat cccctcgttg cacagtttaa acagcgagga ggagcgcatt ttgcgctacg 17640

tgcagcagag cgtgagcctt aacctgatgc gcgacggggt aacgcccagc gtggcgctgg 17700

acatgaccgc gcgcaacatg gaaccgggca tgtatgcctc aaaccggccg tttatcaacc 17760

gcctaatgga ctacttgcat cgcgcggccg ccgtgaaccc cgagtatttc accaatgcca 17820

tcttgaaccc gcactggcta ccgccccctg gtttctacac cgggggattc gaggtgcccg 17880

agggtaacga tggattcctc tgggacgaca tagacgacag cgtgttttcc ccgcaaccgc 17940

agaccctgct agagttgcaa cagcgcgagc aggcagaggc ggcgctgcga aaggaaagct 18000

tccgcaggcc aagcagcttg tccgatctag gcgctgcggc cccgcggtca gatgctagta 18060

gcccatttcc aagcttgata gggtctctta ccagcactcg caccacccgc ccgcgcctgc 18120

tgggcgagga ggagtaccta aacaactcgc tgctgcagcc gcagcgcgaa aaaaacctgc 18180

ctccggcatt tcccaacaac gggatagaga gcctagtgga caagatgagt agatggaaga 18240

cgtacgcgca ggagcacagg gacgtgccag gcccgcgccc gcccacccgt cgtcaaaggc 18300

acgaccgtca gcggggtctg gtgtgggagg acgatgactc ggcagacgac agcagcgtcc 18360

tggatttggg agggagtggc aacccgtttg cgcaccttcg ccccaggctg gggagaatgt 18420

tttaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 18480

ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 18540

tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 18600

cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 18660

aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctggt 18720

ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 18780

gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 18840

tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 18900

aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 18960

gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 19020

gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 19080

cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 19140

ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 19200

aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 19260

cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 19320

gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 19380

ccaggcgagc ttgaaagatg acaccgaaca gggcggggggt ggcgcaggcg gcagcaacag 19440

cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 19500

ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 19560

cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 19620

gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 19680

cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 19740

cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 19800

cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 19860

ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 19920

caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 19980

gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc cagcccccac 20040

catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 20100

caacagcatc ggagagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 20160

ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 20220

agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 20280

aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 20340

gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 20400

tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 20460

gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 20520

gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 20580

acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 20640

ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 20700

ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg gcaacgtgta 20760

ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc ccccgcgcaa 20820

ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag cggcggcggc 20880

gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 20940

ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 21000

ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 21060

cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 21120

acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 21180

gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 21240

gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg agggcaaccc 21300

aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 21360

agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 21420

acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 21480

gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 21540

ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag agggcatgga 21600

gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 21660

ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 21720

cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 21780

tgccctacat ccttccatg cgcctacccc cggctatcgt ggctacacct accgccccag 21840

aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 21900

ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 21960

ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 22020

tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 22080

gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 22140

ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 22200

actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 22260

gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 22320

acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 22380

ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc accagcaata 22440

tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 22500

ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 22560

agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 22620

gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 22680

gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 22740

aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 22800

cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg cccatggcta 22860

ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 22920

agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 22980

ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt ggcaactggc 23040

aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 23100

tctgatagct aacgtgtcgt atgtgtgtca tgtatgcgtc catgtcgccg ccagaggagc 23160

tgctgagccg ccgcgcgccc gctttccaag atggctaccc cttcgatgat gccgcagtgg 23220

tcttacatgc acatctcggg ccaggacgcc tcggagtacc tgagccccgg gctggtgcag 23280

tttgcccgcg ccaccgagac gtacttcagc ctgaataaca agtttagaaa ccccacggtg 23340

gcgcctacgc acgacgtgac cacagaccgg tcccagcgtt tgacgctgcg gttcatccct 23400

gtggaccgtg aggatactgc gtactcgtac aaggcgcggt tcaccctagc tgtgggtgat 23460

aaccgtgtgc tggacatggc ttccacgtac tttgacatcc gcggcgtgct ggacaggggc 23520

cctactttta agccctactc tggcactgcc tacaacgccc tggctcccaa gggtgcccca 23580

aatccttgcg aatgggatga agctgctact gctcttgaaa taaacctaga agaagaggac 23640

gatgacaacg aagacgaagt agacgagcaa gctgagcagc aaaaaactca cgtatttggg 23700

caggcgcctt attctggtat aaatattaca aaggaggta ttcaaatagg tgtcgaaggt 23760

caaacaccta aatatgccga taaaacattt caacctgaac ctcaaatagg agaatctcag 23820

tggtacgaaa cagaaattaa tcatgcagct ggggagagtcc taaaaaagac taccccaatg 23880

aaaccatgtt acggttcata tgcaaaaccc acaaatgaaa atggagggca aggcattctt 23940

gtaaagcaac aaaatggaaa gctagaaagt caagtggaaa tgcaattttt ctcaactact 24000

gaggcagccg caggcaatgg tgataacttg actcctaaag tggtattgta cagtgaagat 24060

gtagatatag aaaccccaga cactcatatt tcttacatgc ccactattaa ggaaggtaac 24120

tcacgagaac taatgggcca acaatctatg cccaacaggc ctaattacat tgcttttagg 24180

gacaatttta ttggtctaat gtattacaac agcacgggta atatgggtgt tctggcgggc 24240

caagcatcgc agttgaatgc tgttgtagat ttgcaagaca gaaacacaga gctttcatac 24300

cagcttttgc ttgattccat tggtgataga accaggtact tttctatgtg gaatcaggct 24360

gttgacagct atgatccaga tgttagaatt attgaaaatc atggaactga agatgaactt 24420

ccaaattact gctttccact gggaggtgtg attaatacag agactcttac caaggtaaaa 24480

cctaaaacag gtcaggaaaa tggatgggaa aaagatgcta cagaattttc agataaaaat 24540

gaaataagag ttggaaataa ttttgccatg gaaatcaatc taaatgccaa cctgtggaga 24600

aatttcctgt actccaacat agcgctgtat ttgcccgaca agctaaagta cagtccttcc 24660

aacgtaaaaa tttctgataa cccaaacacc tacgactaca tgaacaagcg agtggtggct 24720

cccgggctag tggactgcta cattaacctt ggagcacgct ggtcccttga ctatatggac 24780

aacgtcaacc catttaacca ccaccgcaat gctggcctgc gctaccgctc aatgttgctg 24840

ggcaatggtc gctatgtgcc cttccacatc caggtgcctc agaagttctt tgccattaaa 24900

aacctccttc tcctgccggg ctcatacacc tacgagtgga acttcaggaa ggatgttaac 24960

atggttctgc agagctccct aggaaatgac ctaagggttg acggagccag cattaagttt 25020

gatagcattt gcctttacgc caccttcttc cccatggccc acaacaccgc ctccacgctt 25080

gaggccatgc ttagaaacga caccaacgac cagtccttta acgactatct ctccgccgcc 25140

aacatgctct accctatacc cgccaacgct accaacgtgc ccatatccat cccctcccgc 25200

aactgggcgg ctttccgcgg ctgggccttc acgcgcctta agactaagga aaccccatca 25260

ctgggctcgg gctacgaccc ttattacacc tactctggct ctatacccta cctagatgga 25320

accttttacc tcaaccacac ctttaagaag gtggccatta cctttgactc ttctgtcagc 25380

tggcctggca atgaccgcct gcttaccccc aacgagtttg aaattaagcg ctcagttgac 25440

ggggagggtt acaacgttgc ccagtgtaac atgaccaaag actggttcct ggtacaaatg 25500

ctagctaact ataacattgg ctaccagggc ttctatatcc cagagagcta caaggaccgc 25560

atgtactcct tctttagaaa cttccagccc atgagccgtc aggtggtgga tgatactaaa 25620

tacaaggact accaacaggt gggcatccta caccaacaca acaactctgg atttgttggc 25680

taccttgccc cccacatgcg cgaaggacag gcctaccctg ctaacttccc ctatccgctt 25740

ataggcaaga ccgcagttga cagcattacc cagaaaaagt ttctttgcga tcgcaccctt 25800

tggcgcatcc cattctccag taactttatg tccatgggcg cactcacaga cctgggccaa 25860

aaccttctct acgccaactc cgcccacgcg ctagacatga cttttgaggt ggatcccatg 25920

gacgagccca cccttcttta tgttttgttt gaagtctttg acgtggtccg tgtgcaccag 25980

ccgcaccgcg gcgtcatcga aaccgtgtac ctgcgcacgc ccttctcggc cggcaacgcc 26040

acaacataaa gaagcaagca acatcaacaa cagctgccgc catgggctcc agtgagcagg 26100

aactgaaagc cattgtcaaa gatcttggtt gtgggccata ttttttgggc acctatgaca 26160

agcgctttcc aggctttgtt tctccacaca agctcgcctg cgccatagtc aatacggccg 26220

gtcgcgagac tgggggcgta cactggatgg cctttgcctg gaacccgcac tcaaaaacat 26280

gctacctctt tgagcccttt ggcttttctg accagcgact caagcaggtt taccagtttg 26340

agtacgagtc actcctgcgc cgtagcgcca ttgcttcttc ccccgaccgc tgtataacgc 26400

tggaaaagtc cacccaaagc gtacaggggc ccaactcggc cgcctgtgga ctattctgct 26460

gcatgtttct ccacgccttt gccaactggc cccaaactcc catggatcac aaccccacca 26520

tgaaccttat taccggggta cccaactcca tgctcaacag tccccaggta cagcccaccc 26580

tgcgtcgcaa ccaggaacag ctctacagct tcctggagcg ccactcgccc tacttccgca 26640

gccacagtgc gcagattagg agcgccactt ctttttgtca cttgaaaaac atgtaaaaat 26700

aatgtactag agacactttc aataaaggca aatgctttta tttgtacact ctcgggtgat 26760

tatttacccc cacccttgcc gtctgcgccg tttaaaaatc aaaggggttc tgccgcgcat 26820

cgctatgcgc cactggcagg gacacgttgc gatactggtg tttagtgctc cacttaaact 26880

caggcacaac catccgcggc agctcggtga agttttcact ccacaggctg cgcaccatca 26940

ccaacgcgtt tagcaggtcg ggcgccgata tcttgaagtc gcagttgggg cctccgccct 27000

gcgcgcgcga gttgcgatac acagggttgc agcactggaa cactatcagc gccgggtggt 27060

gcacgctggc cagcacgctc ttgtcggaga tcagatccgc gtccaggtcc tccgcgttgc 27120

tcagggcgaa cggagtcaac tttggtagct gccttcccaa aaagggcgcg tgcccaggct 27180

ttgagttgca ctcgcaccgt agtggcatca aaaggtgacc gtgcccggtc tgggcgttag 27240

gatacagcgc ctgcataaaa gccttgatct gcttaaaagc cacctgagcc tttgcgcctt 27300

cagagaagaa catgccgcaa gacttgccgg aaaactgatt ggccggacag gccgcgtcgt 27360

gcacgcagca ccttgcgtcg gtgttggaga tctgcaccac atttcggccc caccggttct 27420

tcacgatctt ggccttgcta gactgctcct tcagcgcgcg ctgcccgttt tcgctcgtca 27480

catccattc aatcacgtgc tccttattta tcataatgct tccgtgtaga cacttaagct 27540

cgccttcgat ctcagcgcag cggtgcagcc acaacgcgca gcccgtgggc tcgtgatgct 27600

tgtaggtcac ctctgcaaac gactgcaggt acgcctgcag gaatcgcccc atcatcgtca 27660

caaaggtctt gttgctggtg aaggtcagct gcaacccgcg gtgctcctcg ttcagccagg 27720

tcttgcatac ggccgccaga gcttccactt ggtcaggcag tagtttgaag ttcgccttta 27780

gatcgttatc cacgtggtac ttgtccatca gcgcgcgcgc agcctccatg cccttctccc 27840

acgcagacac gatcggcaca ctcagcgggt tcatcaccgt aatttcactt tccgcttcgc 27900

tgggctcttc ctcttcctct tgcgtccgca taccacgcgc cactgggtcg tcttcattca 27960

gccgccgcac tgtgcgctta cctcctttgc catgcttgat tagcaccggt gggttgctga 28020

aacccaccat ttgtagcgcc acatcttctc tttcttcctc gctgtccacg attacctctg 28080

gtgatggcgg gcgctcgggc ttgggagaag ggcgcttctt tttcttcttg ggcgcaatgg 28140

ccaaatccgc cgccgaggtc gatggccgcg ggctgggtgt gcgcggcacc agcgcgtctt 28200

gtgatgagtc ttcctcgtcc tcggactcga tacgccgcct catccgcttt tttggggggcg 28260

cccggggagg cggcggcgac ggggacgggg acgacacgtc ctccatggtt gggggacgtc 28320

gcgccgcacc gcgtccgcgc tcggggggtgg tttcgcgctg ctcctcttcc cgactggcca 28380

tttccttctc ctataggcag aaaaagatca tggagtcagt cgagaagaag gacagcctaa 28440

ccgccccctc tgagttcgcc accaccgcct ccaccgatgc cgccaacgcg cctaccacct 28500

tccccgtcga ggcacccccg cttgaggagg aggaagtgat tatcgagcag gacccaggtt 28560

ttgtaagcga agacgacgag gaccgctcag taccaacaga ggataaaaag caagaccagg 28620

acaacgcaga ggcaaacgag gaacaagtcg ggcgggggga cgaaaggcat ggcgactacc 28680

tagatgtggg agacgacgtg ctgttgaagc atctgcagcg ccagtgcgcc attatctgcg 28740

acgcgttgca agagcgcagc gatgtgcccc tcgccatagc ggatgtcagc cttgcctacg 28800

aacgccacct attctcaccg cgcgtacccc ccaaacgcca agaaaacggc acatgcgagc 28860

ccaacccgcg cctcaacttc taccccgtat ttgccgtgcc agaggtgctt gccacctatc 28920

acatcttttt ccaaaactgc aagatacccc tatcctgccg tgccaaccgc agccgagcgg 28980

acaagcagct ggccttgcgg cagggcgctg tcatacctga tatcgcctcg ctcaacgaag 29040

tgccaaaaat ctttgagggt cttggacgcg acgagaagcg cgcggcaaac gctctgcaac 29100

aggaaaacag cgaaaatgaa agtcactctg gagtgttggt ggaactcgag ggtgacaacg 29160

cgcgcctagc cgtactaaaa cgcagcatcg aggtcaccca ctttgcctac ccggcactta 29220

acctaccccc caaggtcatg agcacagtca tgagtgagct gatcgtgcgc cgtgcgcagc 29280

ccctggagag ggatgcaaat ttgcaagaac aaacagagga gggcctaccc gcagttggcg 29340

acgagcagct agcgcgctgg cttcaaacgc gcgagcctgc cgacttggag gagcgacgca 29400

aactaatgat ggccgcagtg ctcgttaccg tggagcttga gtgcatgcag cggttctttg 29460

ctgacccgga gatgcagcgc aagctagagg aaacattgca ctacaccttt cgacagggct 29520

acgtacgcca ggcctgcaag atctccaacg tggagctctg caacctggtc tcctaccttg 29580

gaattttgca cgaaaaccgc cttgggcaaa acgtgcttca ttccacgctc aagggcgagg 29640

cgcgccgcga ctacgtccgc gactgcgttt acttatttct atgctacacc tggcagacgg 29700

ccatgggcgt ttggcagcag tgcttggagg agtgcaacct caagggagctg cagaaactgc 29760

taaagcaaaa cttgaaggac ctatggacgg ccttcaacga gcgctccgtg gccgcgcacc 29820

tggcggacat cattttcccc gaacgcctgc ttaaaaccct gcaacagggt ctgccagact 29880

tcaccagtca aagcatgttg cagaacttta ggaactttat cctagagcgc tcaggaatct 29940

tgcccgccac ctgctgtgca cttcctagcg actttgtgcc cattaagtac cgcgaatgcc 30000

ctccgccgct ttggggccac tgctaccttc tgcagctagc caactacctt gcctaccact 30060

ctgacataat ggaagacgtg agcggtgacg gtctactgga gtgtcactgt cgctgcaacc 30120

tatgcacccc gcaccgctcc ctggtttgca attcgcagct gcttaacgaa agtcaaatta 30180

tcggtacctt tgagctgcag ggtccctcgc ctgacgaaaa gtccgcggct ccggggttga 30240

aactcactcc ggggctgtgg acgtcggctt accttcgcaa atttgtacct gaggactacc 30300

acgcccacga gattaggttc tacgaagacc aatcccgccc gcctaatgcg gagcttaccg 30360

cctgcgtcat tacccagggc cacattcttg gccaattgca agccatcaac aaagcccgcc 30420

aagagtttct gctacgaaag ggacgggggg tttacttgga cccccagtcc ggcgaggagc 30480

tcaacccaat ccccccgccg ccgcagccct atcagcagca gccgcgggcc cttgcttccc 30540

aggatggcac ccaaaaagaa gctgcagctg ccgccgccac ccacggacga ggaggaatac 30600

tgggacagtc aggcagagga ggttttggac gaggaggagg aggacatgat ggaagactgg 30660

gagagcctag acgaggaagc ttccgaggtc gaagaggtgt cagacgaaac accgtcaccc 30720

tcggtcgcat tcccctcgcc ggcgccccag aaatcggcaa ccggttccag catggctaca 30780

acctccgctc ctcaggcgcc gccggcactg cccgttcgcc gacccaaccg tagatgggac 30840

accactggaa cccaggccgg taagtccaag cagccgccgc cgttagccca agagcaacaa 30900

cagcgccaag gctaccgctc atggcgcggg cacaagaacg ccatagttgc ttgcttgcaa 30960

gactgtgggg gcaacatctc cttcgcccgc cgctttcttc tctaccatca cggcgtggcc 31020

ttcccccgta acatcctgca ttactaccgt catctctaca gcccatactg caccggcggc 31080

agcggcagca acagcagcgg ccacacagaa gcaaaggcga ccggatagca agactctgac 31140

aaagcccaag aaatccacag cggcggcagc agcaggagga ggagcgctgc gtctggcgcc 31200

caacgaaccc gtatcgaccc gcgagcttag aaacaggatt tttcccactc tgtatgctat 31260

atttcaacag agcaggggcc aagaacaaga gctgaaaata aaaaacaggt ctctgcgatc 31320

cctcacccgc agctgcctgt atcacaaaag cgaagatcag cttcggcgca cgctggaaga 31380

cgcggaggct ctcttcagta aatactgcgc gctgactctt aaggactagt ttcgcgccct 31440

ttctcaaatt taagcgcgaa aactacgtca tctccagcgg ccacacccgg cgccagcacc 31500

tgttgtcagc gccattatga gcaaggaaat tcccacgccc tacatgtgga gttaccagcc 31560

acaaatggga cttgcggctg gagctgccca agactactca acccgaataa actacatgag 31620

cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa accgaattct 31680

cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc gtagttggcc 31740

cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc ccagagacgc 31800

ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag 31860

ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag gtattcagct 31920

caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat ttcagatcgg 31980

cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc 32040

ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt ttgtgccatc 32100

ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat ttattcctaa 32160

ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg gagaggcaga 32220

gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg cccgcgactc 32280

cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg cgcacggcgt 32340

ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta cccagcgccc 32400

cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca actgtcctaa 32460

ccctggatta catcaagatc ctctagttaa tgtcaggtcg cctaagtcga ttaactagag 32520

tacccgggga tcttattccc tttaactaat aaaaaaaaat aataaagcat cacttactta 32580

aaatcagtta gcaaatttct gtccagttta ttcagcagca cctccttgcc ctcctcccag 32640

ctctggtatt gcagcttcct cctggctgca aactttctcc acaatctaaa tggaatgtca 32700

gtttcctcct gttcctgtcc atccgcaccc actatcttca tgttgttgca gatgaagcgc 32760

gcaagaccgt ctgaagatac cttcaacccc gtgtatccat atgacacgga aaccggtcct 32820

ccaactgtgc cttttcttac tcctcccttt gtatccccca atgggtttca agagagtccc 32880

cctggggtac tctctttgcg cctatccgaa cctctagtta cctccaatgg catgcttgcg 32940

ctcaaaatgg gcaacggcct ctctctggac gaggccggca accttacctc ccaaaatgta 33000

accactgtga gcccacctct caaaaaaacc aagtcaaaca taaacctgga aatatctgca 33060

cccctcacag ttacctcaga agccctaact gtggctgccg ccgcacctct aatggtcgcg 33120

ggcaacacac tcaccatgca atcacaggcc ccgctaaccg tgcacgactc caaacttagc 33180

attgccaccc aaggacccct cacagtgtca gaaggaaagc tagccctgca aacatcaggc 33240

cccctcacca ccaccgatag cagtaccctt actatcactg cctcaccccc tctaactact 33300

gccactggta gcttgggcat tgacttgaaa gagcccattt atacacaaaa tggaaaacta 33360

ggactaaagt acggggctcc tttgcatgta agacgacc taaacacttt gaccgtagca 33420

actggtccag gtgtgactat taataatact tccttgcaaa ctaaagttac tggagccttg 33480

ggttttgatt cacaaggcaa tatgcaactt aatgtagcag gaggactaag gattgattct 33540

caaaacagac gccttatact tgatgttagt tatccgtttg atgctcaaaa ccaactaaat 33600

ctaagactag gacagggccc tctttttata aactcagccc acaacttgga tattaactac 33660

aacaaaggcc tttacttgtt tacagcttca aacaattcca aaaagcttga ggttaaccta 33720

agcactgcca aggggttgat gtttgacgct acagccatag ccattaatgc aggagatggg 33780

cttgaatttg gttcacctaa tgcaccaaac acaaatcccc tcaaaacaaa aattggccat 33840

ggcctagaat ttgattcaaa caaggctatg gttcctaaac taggaactgg ccttagtttt 33900

gacagcacag gtgccattac agtaggaaac aaaaataatg ataagctaac tttgtggacc 33960

ggaataaacc ctccacctaa ctgtcaaatt gtggaaaaca ctaatacaaa tgatggcaaa 34020

cttactttag tattagtaaa aaatggaggg cttgttaatg gctacgtgtc tctagttggt 34080

gtatcagaca ctgtgaacca aatgttcaca caaaagacag caaacatcca attaagatta 34140

tattttgact cttctggaaa tctattaact gaggaatcag acttaaaaat tccacttaaa 34200

aataaatctt ctacagcgac cagtgaaact gtagccagca gcaaagcctt tatgccaagt 34260

actacagctt atcccttcaa caccactact agggatagtg aaaactacat tcatggaata 34320

tgttactaca tgactagtta tgatagaagt ctatttccct tgaacatttc tataatgcta 34380

aacagccgta tgatttcttc caatgttgcc tatgccatac aatttgaatg gaatctaaat 34440

gcaagtgaat ctccagaaag caacatagct acgctgacca catccccctt tttcttttct 34500

tacattacag aagacgacaa ctaaagaatc gtttgtgtta tgtttcaacg tgtttatttt 34560

tcaattgcag aaaatttcaa gtcatttttc attcagtagt atagccccac caccacatag 34620

cttatacaga tcaccgtacc ttaatcaaac tcacagaacc ctagtattca acctgccacc 34680

tccctcccaa cacacagagt acacagtcct ttctccccgg ctggccttaa aaagcatcat 34740

atcatgggta acagacatat tcttaggtgt tatattccac acggtttcct gtcgagccaa 34800

acgctcatca gtgatattaa taaactcccc gggcagctca cttaagttca tgtcgctgtc 34860

cagctgctga gccacaggct gctgtccaac ttgcggttgc ttaacgggcg gcgaaggaga 34920

agtccacgcc tacatggggg tagagtcata atcgtgcatc aggatagggc ggtggtgctg 34980

cagcagcgcg cgaataaact gctgccgccg ccgctccgtc ctgcaggaat acaacatggc 35040

agtggtctcc tcagcgatga ttcgcaccgc ccgcagcata aggcgccttg tcctccgggc 35100

acagcagcgc accctgatct cacttaaatc agcacagtaa ctgcagcaca gcaccacaat 35160

attgttcaaa atcccacagt gcaaggcgct gtatccaaag ctcatggcgg ggaccacaga 35220

acccacgtgg ccatcatacc acaagcgcag gtagattaag tggcgacccc tcataaacac 35280

gctggacata aacattacct cttttggcat gttgtaattc accacctccc ggtaccatat 35340

aaacctctga ttaaacatgg cgccatccac caccatccta aaccagctgg ccaaaacctg 35400

cccgccggct atacactgca gggaaccggg actggaacaa tgacagtgga gagcccagga 35460

ctcgtaacca tggatcatca tgctcgtcat gatatcaatg ttggcacaac acaggcacac 35520

gtgcatacac ttcctcagga ttacaagctc ctcccgcgtt agaaccatat cccagggaac 35580

aacccattcc tgaatcagcg taaatcccac actgcaggga agacctcgca cgtaactcac 35640

gttgtgcatt gtcaaagtgt tacattcggg cagcagcgga tgatcctcca gtatggtagc 35700

gcgggtttct gtctcaaaag gaggtagacg atccctactg tacggagtgc gccgagacaa 35760

ccgagatcgt gttggtcgta gtgtcatgcc aaatggaacg ccggacgtag tcatatttcc 35820

tgaagcaaaa ccaggtgcgg gcgtgacaaa cagatctgcg tctccggtct cgccgcttag 35880

atcgctctgt gtagtagttg tagtatatcc actctctcaa agcatccagg cgccccctgg 35940

cttcgggttc tatgtaaact ccttcatgcg ccgctgccct gataacatcc accaccgcag 36000

aataagccac acccagccaa cctacacatt cgttctgcga gtcacacacg ggagggagcgg 36060

gaagagctgg aagaaccatg tttttttttt tattccaaaa gattatccaa aacctcaaaa 36120

tgaagatcta ttaagtgaac gcgctcccct ccggtggcgt ggtcaaactc tacagccaaa 36180

gaacagataa tggcatttgt aagatgttgc acaatggctt ccaaaaggca aacggccctc 36240

acgtccaagt ggacgtaaag gctaaaccct tcagggtgaa tctcctctat aaacattcca 36300

gcaccttcaa ccatgcccaa ataattctca tctcgccacc ttctcaatat atctctaagc 36360

aaatcccgaa tattaagtcc ggccattgta aaaatctgct ccagagcgcc ctccaccttc 36420

agcctcaagc agcgaatcat gattgcaaaa attcaggttc ctcacagacc tgtataagat 36480

tcaaaagcgg aacattaaca aaaataccgc gatcccgtag gtcccttcgc agggccagct 36540

gaacataatc gtgcaggtct gcacggacca gcgcggccac ttccccgcca ggaaccatga 36600

caaaagaacc cacactgatt atgacacgca tactcggagc tatgctaacc agcgtagccc 36660

cgatgtaagc ttgttgcatg ggcggcgata taaaatgcaa ggtgctgctc aaaaaatcag 36720

gcaaagcctc gcgcaaaaaa gaaagcacat cgtagtcatg ctcatgcaga taaaggcagg 36780

taagctccgg aaccaccaca gaaaaagaca ccatttttct ctcaaacatg tctgcgggtt 36840

tctgcataaa cacaaaataa aataacaaaa aaacatttaa acattagaag cctgtcttac 36900

aacaggaaaa acaaccctta taagcataag acggactacg gccatgccgg cgtgaccgta 36960

aaaaaactgg tcaccgtgat taaaaagcac caccgacagc tcctcggtca tgtccggagt 37020

cataatgtaa gactcggtaa acacatcagg ttgattcaca tcggtcagtg ctaaaaagcg 37080

accgaaatag cccgggggaa tacatacccg caggcgtaga gacaacatta cagcccccat 37140

aggaggtata acaaaattaa taggagagaa aaacacataa acacctgaaa aaccctcctg 37200

cctaggcaaa atagcaccct cccgctccag aacaacatac agcgcttcca cagcggcagc 37260

cataacagtc agccttacca gtaaaaaaga aaacctatta aaaaaacacc actcgacacg 37320

gcaccagctc aatcagtcac agtgtaaaaa agggccaagt gcagagcgag tatatatagg 37380

actaaaaaat gacgtaacgg ttaaagtcca caaaaaacac ccagaaaacc gcacgcgaac 37440

ctacgcccag aaacgaaagc caaaaaaccc acaacttcct caaatcgtca cttccgtttt 37500

cccacgttac gtcacttccc attttaagaa aactacaatt cccaacacat acaagttact 37560

ccgccctaaa acctacgtca cccgccccgt tcccacgccc cgcgccacgt cacaaactcc 37620

accccctcat tatcatattg gcttcaatcc aaaataaggt atattattga tgatg 37675

<210> 27

<211> 34736

<212> DNA

<213> Artificial sequence

<220>

<223> vector #3

<400> 27

catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tactgtaata gtaatcaatt 360

acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420

ggcccgcctg gctgaccgcc caacgacccc cgcccatga cgtcaataat gacgtatgtt 480

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660

acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720

tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt 780

gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840

aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900

agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020

agacaccggg accgatccag cctccgattt gccaccatgt ttgtgttcct ggtgctgctg 1080

ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc tcctgcctac 1140

accaactcct tcaccagggg agtctactac cctgacaagg tgttcaggtc ctctgtgctg 1200

cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt ccatgccatc 1260

catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc attcaatgat 1320

ggagtctact ttgccagcac agagaagagc aacatcatca ggggctggat ttttggcacc 1380

accctggaca gcaagacca gtccctgctg attgtgaaca atgccaccaa tgtggtgatt 1440

aaggtgtgtg agttccagtt ctgtaatgac ccattcctgg gagtctacta ccacaagaac 1500

aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa ctgtaccttt 1560

gaatatgtga gccaaccatt cctgatggac ttggagggca agcagggcaa cttcaagaac 1620

ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag caaacacaca 1680

ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc actggtggac 1740

ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca caggtcctac 1800

ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta ctatgtgggc 1860

tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat cacagatgct 1920

gtggactgtg ccctggaccc actngtctgag accaagtgta ccctgaaatc cttcacagtg 1980

gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag cattgtgagg 2040

tttccaaaca tcaccaacct gtgtccatt ggagaggtgt tcaatgccac caggtttgcc 2100

tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta ctctgtgctc 2160

tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac caaactgaat 2220

gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga tgaggtgaga 2280

cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact gcctgatgac 2340

ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt gggaggcaac 2400

tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga gagggacatc 2460

agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg cttcaactgt 2520

tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta ccaaccatac 2580

agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgtg tggaccaaag 2640

aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg actgacaggc 2700

acaggagtgc tgacagagag caacaagaag ttcctgccat tccaacagtt tggcagggac 2760

attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct ggacatcaca 2820

ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag caaccaggtg 2880

gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca tgctgaccaa 2940

cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac cagggctggc 3000

tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc aattggagca 3060

ggcatctgtg cctcctacca gacccagacc ggtggcggtg ggtcgaggtc tgtggcaagc 3120

cagagcatca ttgcctacac aatgagtctg ggagcagaga actctgtggc ttacagcaac 3180

aacagcattg ccatcccaac caacttcacc atctctgtga cccacagat tctgcctgtg 3240

agtatgacca agacctctgt ggactgtaca atgtatatct gtggagacag cacagagtgt 3300

agcaacctgc tgctccaata tggctccttc tgtacccaac ttaacagggc tctgacaggc 3360

attgctgtgg aacaggacaa gaacacccag gaggtgtttg cccaggtgaa gcagatttac 3420

aagacacctc caatcaagga ctttggaggc ttcaacttca gccagattct gcctgaccca 3480

agcaagccaa gcaagaggtc cttcattgag gacctgctgt tcaacaaggt gaccctggct 3540

gatgctggct tcatcaagca atatggagac tgtctgggag acattgctgc cagggacctg 3600

atttgtgccc agaagttcaa tggactgaca gtgctgcctc cactgctgac agatgagatg 3660

attgcccaat acacctctgc cctgctggct ggcaccatca cctctggctg gacctttgga 3720

gcaggagcag ccctccaaat cccatttgct atgcagatgg cttacaggtt caatggcatt 3780

ggagtgaccc agaatgtgct ctatgagaac cagaaactga ttgccaacca gttcaactct 3840

gccattggca agattcagga ctccctgtcc agcacagcct ctgccctggg caaactccaa 3900

gatgtggtga accagaatgc ccaggctctg aacaccctgg tgaagcaact ttccagcaac 3960

tttggagcca tctcctctgt gctgaatgac atcctgagca gactggacaa ggtggaggct 4020

gaggtccaga ttgacagact gattacaggc agactccaat ccctccaaac ctatgtgacc 4080

caacaactta tcagggctgc tgagattagg gcatctgcca acctggctgc caccaagatg 4140

agtgagtgtg tgctgggaca aagcaagagg gtggacttct gtggcaaggg ctaccacctg 4200

atgagttttc cacagtctgc ccctcatgga gtggtgttcc tgcatgtgac ctatgtgcct 4260

gcccaggaga agaacttcac cacagcccct gccatctgcc atgatggcaa ggctcacttt 4320

ccaagggagg gagtgtttgt gagcaatggc acccactggt ttgtgaccca gaggaacttc 4380

tatgaaccac agattatcac cacagacaac acctttgtgt ctggcaactg tgatgtggtg 4440

attggcattg tgaacaacac agtctatgac ccactccaac ctgaactgga ctccttcaag 4500

gaggaactgg acaaatactt caagaaccac accagccctg atgtggacct gggagacatc 4560

tctggcatca atgcctctgt ggtgaacatc cagaaggaga ttgacagact gaatgaggtg 4620

gctaagaacc tgaatgagtc cctgattgac ctccaagaac tgggcaaata tgaacaatac 4680

atcaagtggc catgaaaatt gatcataatc agccatacca catttgtaga ggttttactt 4740

gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt 4800

gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat 4860

ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat 4920

gtatcttaac gcggatctgg gcgtggttaa gggtgggaaa gaatatataa ggtgggggtc 4980

ttatgtagtt ttgtatctgt tttgcagcag ccgccgccgc catgagcacc aactcgtttg 5040

atggaagcat tgtgagctca tatttgacaa cgcgcatgcc cccatggggcc ggggtgcgtc 5100

agaatgtgat gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct 5160

tgacctacga gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag 5220

ccgctgcagc caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa 5280

gcagtgcagc ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat 5340

tggattcttt gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc 5400

aggtttctgc cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac 5460

cagactctgt ttggatttgg atcaagcaag tgtcttgctg tctttattta ggggttttgc 5520

gcgcgcggta ggcccgggac cagcggtctc ggtcgttgag ggtcctgtgt attttttcca 5580

ggacgtggta aaggtgactc tggatgttca gatacatggg cataagcccg tctctggggt 5640

ggaggtagca ccactgcaga gcttcatgct gcggggtggt gttgtagatg atccagtcgt 5700

agcaggagcg ctgggcgtgg tgcctaaaaa tgtctttcag tagcaagctg attgccaggg 5760

gcaggccctt ggtgtaagtg tttacaaagc ggttaagctg ggatgggtgc atacgtgggg 5820

atatgagatg catcttggac tgtattttta ggttggctat gttcccagcc atatccctcc 5880

ggggattcat gttgtgcaga accaccagca cagtgtatcc ggtgcacttg ggaaatttgt 5940

catgtagctt agaaggaaat gcgtggaaga acttggagac gcccttgtga cctccaagat 6000

tttccatgca ttcgtccata atgatggcaa tgggcccacg ggcggcggcc tgggcgaaga 6060

tatttctggg atcactaacg tcatagttgt gttccaggat gagatcgtca taggccattt 6120

ttacaaagcg cgggcggagg gtgccagact gcggtataat ggttccatcc ggcccagggg 6180

cgtagttacc ctcacagatt tgcatttccc acgctttgag ttcagatggg gggatcatgt 6240

ctacctgcgg ggcgatgaag aaaacggttt ccggggtagg ggagatcagc tgggaagaaa 6300

gcaggttcct gagcagctgc gacttaccgc agccggtggg cccgtaaatc acacctatta 6360

ccggctgcaa ctggtagtta agagagctgc agctgccgtc atccctgagc aggggggcca 6420

cttcgttaag catgtccctg actcgcatgt tttccctgac caaatccgcc agaaggcgct 6480

cgccgcccag cgatagcagt tcttgcaagg aagcaaagtt tttcaacggt ttgagaccgt 6540

ccgccgtagg catgcttttg agcgtttgac caagcagttc caggcggtcc cacagctcgg 6600

tcacctgctc tacggcatct cgatccagca tatctcctcg tttcgcgggt tggggcggct 6660

ttcgctgtac ggcagtagtc ggtgctcgtc cagacggggcc agggtcatgt ctttccacgg 6720

gcgcagggtc ctcgtcagcg tagtctgggt cacggtgaag gggtgcgctc cgggctgcgc 6780

gctggccagg gtgcgcttga ggctggtcct gctggtgctg aagcgctgcc ggtcttcgcc 6840

ctgcgcgtcg gccaggtagc atttgaccat ggtgtcatag tccagcccct ccgcggcgtg 6900

gcccttggcg cgcagcttgc ccttggagga ggcgccgcac gaggggcagt gcagactttt 6960

gagggcgtag agcttgggcg cgagaaatac cgattccggg gagtaggcat ccgcgccgca 7020

ggccccgcag acggtctcgc attccacgag ccaggtgagc tctggccgtt cggggtcaaa 7080

aaccaggttt cccccatgct ttttgatgcg tttcttacct ctggtttcca tgagccggtg 7140

tccacgctcg gtgacgaaaa ggctgtccgt gtccccgtat acagacttga gaggcctgtc 7200

ctcgagcggt gttccgcggt cctcctcgta tagaaactcg gaccactctg agacaaaggc 7260

tcgcgtccag gccagcacga aggaggctaa gtgggagggg tagcggtcgt tgtccactag 7320

ggggtccact cgctccagg tgtgaagaca catgtcgccc tcttcggcat caaggaaggt 7380

gattggtttg taggtgtagg ccacgtgacc gggtgttcct gaaggggggc tataaaaggg 7440

ggtggggggcg cgttcgtcct cactctcttc cgcatcgctg tctgcgaggg ccagctgttg 7500

gggtgagtac tccctctgaa aagcgggcat gacttctgcg ctaagattgt cagtttccaa 7560

aaacgaggag gatttgatat tcacctggcc cgcggtgatg cctttgaggg tggccgcatc 7620

catctggtca gaaaagacaa tctttttgtt gtcaagcttg gtggcaaacg acccgtagag 7680

ggcgttggac agcaacttgg cgatggagcg cagggtttgg tttttgtcgc gatcggcgcg 7740

ctccttggcc gcgatgttta gctgcacgta ttcgcgcgca acgcaccgcc attcgggaaa 7800

gacggtggtg cgctcgtcgg gcaccaggtg cacgcgccaa ccgcggttgt gcagggtgac 7860

aaggtcaacg ctggtggcta cctctccgcg taggcgctcg ttggtccagc agaggcggcc 7920

gcccttgcgc gagcagaatg gcggtagggg gtctagctgc gtctcgtccg gggggtctgc 7980

gtccacggta aagaccccgg gcagcaggcg cgcgtcgaag tagtctatct tgcatccttg 8040

caagtctagc gcctgctgcc atgcgcgggc ggcaagcgcg cgctcgtatg ggttgagtgg 8100

gggaccccat ggcatggggt gggtgagcgc ggaggcgtac atgccgcaaa tgtcgtaaac 8160

gtagaggggc tctctgagta ttccaagata tgtagggtag catcttccac cgcggatgct 8220

ggcgcgcacg taatcgtata gttcgtgcga gggagcgagg aggtcgggac cgaggttgct 8280

acgggcgggc tgctctgctc ggaagactat ctgcctgaag atggcatgtg agttggatga 8340

tatggttgga cgctggaaga cgttgaagct ggcgtctgtg agacctaccg cgtcacgcac 8400

gaaggaggcg taggagtcgc gcagcttgtt gaccagctcg gcggtgacct gcacgtctag 8460

ggcgcagtag tccagggttt ccttgatgat gtcatactta tcctgtccct tttttttcca 8520

cagctcgcgg ttgaggacaa actcttcgcg gtctttccag tactcttgga tcggaaaccc 8580

gtcggcctcc gaacggtaag agcctagcat gtagaactgg ttgacggcct ggtaggcgca 8640

gcatcccttt tctacgggta gcgcgtatgc ctgcgcggcc ttccggagcg aggtgtgggt 8700

gagcgcaaag gtgtccctga ccatgacttt gaggtactgg tatttgaagt cagtgtcgtc 8760

gcatccgccc tgctcccaga gcaaaaagtc cgtgcgcttt ttggaacgcg gatttggcag 8820

ggcgaaggtg acatcgttga agagtatctt tcccgcgcga ggcataaagt tgcgtgtgat 8880

gcggaagggt cccggcacct cggaacggtt gttaattacc tgggcggcga gcacgatctc 8940

gtcaaagccg ttgatgttgt ggcccacaat gtaaagttcc aagaagcgcg ggatgccctt 9000

gatggaaggc aattttttaa gttcctcgta ggtgagctct tcaggggagc tgagcccgtg 9060

ctctgaaagg gcccagtctg caagatgagg gttggaagcg acgaatgagc tccacaggtc 9120

acgggccatt agcatttgca ggtggtcgcg aaaggtccta aactggcgac ctatggccat 9180

tttttctggg gtgatgcagt agaaggtaag cgggtcttgt tcccagcggt cccatccaag 9240

gttcgcggct aggtctcgcg cggcagtcac tagaggctca tctccgccga acttcatgac 9300

cagcatgaag ggcacgagct gcttcccaaa ggcccccatc caagtatagg tctctacatc 9360

gtaggtgaca aagagacgct cggtgcgagg atgcgagccg atcgggaaga actggatctc 9420

ccgccaccaa ttggagggagt ggctattgat gtggtgaaag tagaagtccc tgcgacgggc 9480

cgaacactcg tgctggcttt tgtaaaaacg tgcgcagtac tggcagcggt gcacgggctg 9540

tacatcctgc acgaggttga cctgacgacc gcgcacaagg aagcagagtg ggaatttgag 9600

cccctcgcct ggcgggtttg gctggtggtc ttctacttcg gctgcttgtc cttgaccgtc 9660

tggctgctcg aggggagtta cggtggatcg gaccaccacg ccgcgcgagc ccaaagtcca 9720

gatgtccgcg cgcggcggtc ggagcttgat gacaacatcg cgcagatggg agctgtccat 9780

ggtctggagc tcccgcggcg tcaggtcagg cgggagctcc tgcaggttta cctcgcatag 9840

acgggtcagg gcgcgggcta gatccaggtg atacctaatt tccaggggct ggttggtggc 9900

ggcgtcgatg gcttgcaaga ggccgcatcc ccgcggcgcg actacggtac cgcgcggcgg 9960

gcggtgggcc gcggggggtgt ccttggatga tgcatctaaa agcggtgacg cgggcgagcc 10020

cccggaggta gggggggctc cggacccgcc gggagagggg gcaggggcac gtcggcgccg 10080

cgcgcgggca ggagctggtg ctgcgcgcgt aggttgctgg cgaacgcgac gacgcggcgg 10140

ttgatctcct gaatctggcg cctctgcgtg aagacgacgg gcccggtgag cttgaacctg 10200

aaagagagtt cgacagaatc aatttcggtg tcgttgacgg cggcctggcg caaaatctcc 10260

tgcacgtctc ctgagttgtc ttgataggcg atctcggcca tgaactgctc gatctcttcc 10320

tcctggagat ctccgcgtcc ggctcgctcc acggtggcgg cgaggtcgtt ggaaatgcgg 10380

gccatgagct gcgagaaggc gttgaggcct ccctcgttcc agacgcggct gtagaccacg 10440

cccccttcgg catcgcgggc gcgcatgacc acctgcgcga gattgagctc cacgtgccgg 10500

gcgaagacgg cgtagtttcg caggcgctga aagaggtagt tgaggtggt ggcggtgtgt 10560

tctgccacga agaagtacat aacccagcgt cgcaacgtgg attcgttgat atcccccaag 10620

gcctcaaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa ctgggagttg 10680

cgcgccgaca cggttaactc ctcctccaga agacggatga gctcggcgac agtgtcgcgc 10740

acctcgcgct caaaggctac aggggcctct tcttcttctt caatctcctc ttccataagg 10800

gcctcccctt cttcttcttc tggcggcggt gggggagggg ggacacggcg gcgacgacgg 10860

cgcaccggga ggcggtcgac aaagcgctcg atcatctccc cgcggcgacg gcgcatggtc 10920

tcggtgacgg cgcggccgtt ctcgcggggg cgcagttgga agacgccgcc cgtcatgtcc 10980

cggttatggg ttggcggggg gctgccatgc ggcagggata cggcgctaac gatgcatctc 11040

aacaattgtt gtgtaggtac tccgccgccg agggacctga gcgagtccgc atcgaccgga 11100

tcggaaaacc tctcgagaaa ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc 11160

gtggcgggcg gcagcgggcg gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg 11220

taattaaagt aggcggtctt gagacggcgg atggtcgaca gaagcaccat gtccttgggt 11280

ccggcctgct gaatgcgcag gcggtcggcc atgccccagg cttcgttttg acatcggcgc 11340

aggtctttgt agtagtcttg catgagcctt tctaccggca cttcttcttc tccttcctct 11400

tgtcctgcat ctcttgcatc tatcgctgcg gcggcggcgg agtttggccg taggtggcgc 11460

cctcttcctc ccatgcgtgt gaccccgaag cccctcatcg gctgaagcag ggctaggtcg 11520

gcgacaacgc gctcggctaa tatggcctgc tgcacctgcg tgaggtaga ctggaagtca 11580

tccatgtcca caaagcggtg gtatgcgccc gtgttgatgg tgtaagtgca gttggccata 11640

acggaccagt taacggtctg gtgacccggc tgcgagagct cggtgtacct gagacgcgag 11700

taagccctcg agtcaaatac gtagtcgttg caagtccgca ccaggtactg gtatcccacc 11760

aaaaagtgcg gcggcggctg gcggtagagg ggccagcgta gggtggccgg ggctccgggg 11820

gcgagatctt ccaacataag gcgatgatat ccgtagatgt acctggacat ccaggtgatg 11880

ccggcggcgg tggtggaggc gcgcggaaag tcgcggacgc ggttccagat gttgcgcagc 11940

ggcaaaaagt gctccatggt cgggacgctc tggccggtca ggcgcgcgca atcgttgacg 12000

ctctagcgtg caaaaggaga gcctgtaagc gggcactctt ccgtggtctg gtggataaat 12060

tcgcaagggt atcatggcgg acgaccgggg ttcgagcccc gtatccggcc gtccgccgtg 12120

atccatgcgg ttaccgcccg cgtgtcgaac ccaggtgtgc gacgtcagac aacgggggag 12180

tgctcctttt ggcttccttc caggcgcggc ggctgctgcg ctagcttttt tggccactgg 12240

ccgcgcgcag cgtaagcggt taggctggaa agcgaaagca ttaagtggct cgctccctgt 12300

agccggaggg ttattttcca agggttgagt cgcgggaccc ccggttcgag tctcggaccg 12360

gccggactgc ggcgaacggg ggtttgcctc cccgtcatgc aagaccccgc ttgcaaattc 12420

ctccggaaac agggacgagc cccttttttg cttttcccag atgcatccgg tgctgcggca 12480

gatgcgcccc cctcctcagc agcggcaaga gcaagagcag cggcagacat gcagggcacc 12540

ctcccctcct cctaccgcgt caggaggggc gacatccgcg gttgacgcgg cagcagatgg 12600

tgattacgaa cccccgcggc gccgggcccg gcactacctg gacttggagg agggcgagg 12660

cctggcgcgg ctaggagcgc cctctcctga gcggcaccca agggtgcagc tgaagcgtga 12720

tacgcgtgag gcgtacgtgc cgcggcagaa cctgtttcgc gaccgcgagg gagaggagcc 12780

cgaggagatg cgggatcgaa agttccacgc agggcgcgag ctgcggcatg gcctgaatcg 12840

cgagcggttg ctgcgcgagg aggactttga gcccgacgcg cgaaccggga ttagtcccgc 12900

gcgcgcacac gtggcggccg ccgacctggt aaccgcatac gagcagacgg tgaaccagga 12960

gattaacttt caaaaaagct ttaacaacca cgtgcgtacg cttgtggcgc gcgaggaggt 13020

ggctatagga ctgatgcatc tgtgggactt tgtaagcgcg ctggagcaaa acccaaatag 13080

caagccgctc atggcgcagc tgttccttat agtgcagcac agcagggaca acgaggcatt 13140

cagggatgcg ctgctaaaca tagtagagcc cgagggccgc tggctgctcg atttgataaa 13200

catcctgcag agcatagtgg tgcaggagcg cagcttgagc ctggctgaca aggtggccgc 13260

catcaactat tccatgctta gcctgggcaa gttttacgcc cgcaagatat accatacccc 13320

ttacgttccc atagacaagg aggtaaagat cgaggggttc tacatgcgca tggcgctgaa 13380

ggtgcttacc ttgagcgacg acctgggcgt ttatcgcaac gagcgcatcc acaaggccgt 13440

gagcgtgagc cggcggcgcg agctcagcga ccgcgagctg atgcacagcc tgcaaagggc 13500

cctggctggc acgggcagcg gcgatagaga ggccgagtcc tactttgacg cgggcgctga 13560

cctgcgctgg gccccaagcc gacgcgccct ggaggcagct ggggccggac ctgggctggc 13620

ggtggcaccc gcgcgcgctg gcaacgtcgg cggcgtggag gaatatgacg aggacgatga 13680

gtacgagcca gaggacggcg agtactaagc ggtgatgttt ctgatcagat gatgcaagac 13740

gcaacggacc cggcggtgcg ggcggcgctg cagagccagc cgtccggcct taactccacg 13800

gacgactggc gccaggtcat ggaccgcatc atgtcgctga ctgcgcgcaa tcctgacgcg 13860

ttccggcagc agccgcaggc caaccggctc tccgcaattc tggaagcggt ggtcccggcg 13920

cgcgcaaacc ccacgcacga gaaggtgctg gcgatcgtaa acgcgctggc cgaaaacagg 13980

gccatccggc ccgacgaggc cggcctggtc tacgacgcgc tgcttcagcg cgtggctcgt 14040

tacaacagcg gcaacgtgca gaccaacctg gaccggctgg tgggggatgt gcgcgaggcc 14100

gtggcgcagc gtgagcgcgc gcagcagcag ggcaacctgg gctccatggt tgcactaaac 14160

gccttcctga gtacacagcc cgccaacgtg ccgcggggac aggaggacta caccaacttt 14220

gtgagcgcac tgcggctaat ggtgactgag acaccgcaaa gtgaggtgta ccagtctggg 14280

ccagactatt ttttccagac cagtagacaa ggcctgcaga ccgtaaacct gagccaggct 14340

ttcaaaaact tgcaggggct gtggggggtg cgggctccca caggcgaccg cgcgaccgtg 14400

tctagcttgc tgacgcccaa ctcgcgcctg ttgctgctgc taatagcgcc cttcacggac 14460

agtggcagcg tgtcccggga cacataccta ggtcacttgc tgacactgta ccgcgaggcc 14520

ataggtcagg cgcatgtgga cgagcatact ttccaggaga ttacaagtgt cagccgcgcg 14580

ctggggcagg aggacacggg cagcctggag gcaaccctaa actacctgct gaccaaccgg 14640

cggcagaaga tcccctcgtt gcacagttta aacagcgagg aggagcgcat tttgcgctac 14700

gtgcagcaga gcgtgagcct taacctgatg cgcgacgggg taacgcccag cgtggcgctg 14760

gacatgaccg cgcgcaacat ggaaccgggc atgtatgcct caaaccggcc gtttatcaac 14820

cgcctaatgg actacttgca tcgcgcggcc gccgtgaacc ccgagtattt caccaatgcc 14880

atcttgaacc cgcactggct accgccccct ggtttctaca ccggggggatt cgaggtgccc 14940

gagggtaacg atggattcct ctgggacgac atagacgaca gcgtgttttc cccgcaaccg 15000

cagaccctgc tagagttgca acagcgcgag caggcagagg cggcgctgcg aaaggaaagc 15060

ttccgcaggc caagcagctt gtccgatcta ggcgctgcgg ccccgcggtc agatgctagt 15120

agcccatttc caagcttgat agggtctctt accagcactc gcaccacccg cccgcgcctg 15180

ctgggcgagg aggagtacct aaacaactcg ctgctgcagc cgcagcgcga aaaaaacctg 15240

cctccggcat ttcccaacaa cgggatagag agcctagtgg acaagatgag tagatggaag 15300

acgtacgcgc aggagcacag ggacgtgcca ggcccgcgcc cgcccacccg tcgtcaaagg 15360

cacgaccgtc agcggggtct ggtgtgggag gacgatgact cggcagacga cagcagcgtc 15420

ctggatttgg gagggagtgg caacccgttt gcgcaccttc gccccaggct ggggagaatg 15480

ttttaaaaaa aaaaaagcat gatgcaaaat aaaaaactca ccaaggccat ggcaccgagc 15540

gttggttttc ttgtattccc cttagtatgc ggcgcgcggc gatgtatgag gaaggtcctc 15600

ctccctccta cgagagtgtg gtgagcgcgg cgccagtggc ggcggcgctg ggttctccct 15660

tcgatgctcc cctggacccg ccgtttgtgc ctccgcggta cctgcggcct accgggggga 15720

gaaacagcat ccgttactct gagttggcac ccctattcga caccacccgt gtgtacctgg 15780

tggacaacaa gtcaacggat gtggcatccc tgaactacca gaacgaccac agcaactttc 15840

tgaccacggt cattcaaaac aatgactaca gcccggggga ggcaagcaca cagaccatca 15900

atcttgacga ccggtcgcac tggggcggcg acctgaaaac catcctgcat accaacatgc 15960

caaatgtgaa cgagttcatg tttaccaata agtttaaggc gcgggtgatg gtgtcgcgct 16020

tgcctactaa ggacaatcag gtggagctga aatacgagtg ggtggagttc acgctgcccg 16080

agggcaacta ctccgagacc atgaccatag accttatgaa caacgcgatc gtggagcact 16140

acttgaaagt gggcagacag aacggggttc tggaaagcga catcggggta aagtttgaca 16200

cccgcaactt cagactgggg tttgaccccg tcactggtct tgtcatgcct ggggtatata 16260

caaacgaagc cttccatcca gacatcattt tgctgccagg atgcggggtg gacttcaccc 16320

acagccgcct gagcaacttg ttgggcatcc gcaagcggca acccttccag gagggcttta 16380

ggatcaccta cgatgatctg gagggtggta acattcccgc actgttggat gtggacgcct 16440

accaggcgag cttgaaagat gacaccgaac agggcggggg tggcgcaggc ggcagcaaca 16500

gcagtggcag cggcgcggaa gagaactcca acgcggcagc cgcggcaatg cagccggtgg 16560

aggacatgaa cgatcatgcc attcgcggcg acacctttgc cacacgggct gaggagaagc 16620

gcgctgaggc cgaagcagcg gccgaagctg ccgcccccgc tgcgcaaccc gaggtcgaga 16680

agcctcagaa gaaaccggtg atcaaacccc tgacagagga cagcaagaaa cgcagttaca 16740

acctaataag caatgacagc accttcaccc agtaccgcag ctggtacctt gcatacaact 16800

acggcgaccc tcagaccgga atccgctcat ggaccctgct ttgcactcct gacgtaacct 16860

gcggctcgga gcaggtctac tggtcgttgc cagacatgat gcaagacccc gtgaccttcc 16920

gctccacgcg ccagatcagc aactttccgg tggtgggcgc cgagctgttg cccgtgcact 16980

ccaagagctt ctacaacgac caggccgtct actcccaact catccgccag tttacctctc 17040

tgacccacgt gttcaatcgc tttcccgaga accagatttt ggcgcgcccg ccagccccca 17100

ccatcaccac cgtcagtgaa aacgttcctg ctctcacaga tcacgggacg ctaccgctgc 17160

gcaacagcat cggaggagtc cagcgagtga ccattactga cgccagacgc cgcacctgcc 17220

cctacgttta caaggccctg ggcatagtct cgccgcgcgt cctatcgagc cgcacttttt 17280

gagcaagcat gtccatcctt atatcgccca gcaataacac aggctggggc ctgcgcttcc 17340

caagcaagat gtttggcggg gccaagaagc gctccgacca acacccagtg cgcgtgcgcg 17400

ggcactaccg cgcgccctgg ggcgcgcaca aacgcggccg cactgggcgc accaccgtcg 17460

atgacgccat cgacgcggtg gtggaggagg cgcgcaacta cacgcccacg ccgccaccag 17520

tgtccacagt ggacgcggcc attcagaccg tggtgcgcgg agcccggcgc tatgctaaaa 17580

tgaagagacg gcggaggcgc gtagcacgtc gccaccgccg ccgacccggc actgccgccc 17640

aacgcgcggc ggcggccctg cttaaccgcg cacgtcgcac cggccgacgg gcggccatgc 17700

gggccgctcg aaggctggcc gcgggtattg tcactgtgcc ccccaggtcc aggcgacgag 17760

cggccgccgc agcagccgcg gccattagtg ctatgactca gggtcgcagg ggcaacgtgt 17820

attgggtgcg cgactcggtt agcggcctgc gcgtgcccgt gcgcacccgc cccccgcgca 17880

actagattgc aagaaaaaac tacttagact cgtactgttg tatgtatcca gcggcggcgg 17940

cgcgcaacga agctatgtcc aagcgcaaaa tcaaagaaga gatgctccag gtcatcgcgc 18000

cggagatcta tggccccccg aagaaggaag agcaggatta caagccccga aagctaaagc 18060

gggtcaaaaa gaaaaagaaa gatgatgatg atgaacttga cgacgaggtg gaactgctgc 18120

acgctaccgc gcccaggcga cgggtacagt ggaaaggtcg acgcgtaaaa cgtgttttgc 18180

gacccggcac caccgtagtc tttacgcccg gtgagcgctc cacccgcacc tacaagcgcg 18240

tgtatgatga ggtgtacggc gacgaggacc tgcttgagca ggccaacgag cgcctcgggg 18300

agtttgccta cggaaagcgg cataaggaca tgctggcgtt gccgctggac gagggcaacc 18360

caacacctag cctaaagccc gtaacactgc agcaggtgct gcccgcgctt gcaccgtccg 18420

aagaaaagcg cggcctaaag cgcgagtctg gtgacttggc acccaccgtg cagctgatgg 18480

tacccaagcg ccagcgactg gaagatgtct tggaaaaaat gaccgtggaa cctgggctgg 18540

agcccgaggt ccgcgtgcgg ccaatcaagc aggtggcgcc gggactgggc gtgcagaccg 18600

tggacgttca gatacccact accagtagca ccagtattgc caccgccaca gagggcatgg 18660

agacacaaac gtccccggtt gcctcagcgg tggcggatgc cgcggtgcag gcggtcgctg 18720

cggccgcgtc caagacctct acggaggtgc aaacggaccc gtggatgttt cgcgtttcag 18780

ccccccggcg cccgcgccgt tcgaggaagt acggcgccgc cagcgcgcta ctgcccgaat 18840

atgccctaca tccttccatt gcgcctaccc ccggctatcg tggctacacc taccgcccca 18900

gaagacgagc aactacccga cgccgaacca ccactggaac ccgccgccgc cgtcgccgtc 18960

gccagcccgt gctggccccg atttccgtgc gcagggtggc tcgcgaagga ggcaggaccc 19020

tggtgctgcc aacagcgcgc taccacccca gcatcgttta aaagccggtc tttgtggttc 19080

ttgcagatat ggccctcacc tgccgcctcc gtttcccggt gccgggattc cgaggaagaa 19140

tgcaccgtag gaggggcatg gccggccacg gcctgacggg cggcatgcgt cgtgcgcacc 19200

accggcggcg gcgcgcgtcg caccgtcgca tgcgcggcgg tatcctgccc ctccttattc 19260

cactgatcgc cgcggcgatt ggcgccgtgc ccggaattgc atccgtggcc ttgcaggcgc 19320

agagacactg attaaaaaca agttgcatgt ggaaaaatca aaataaaaag tctggactct 19380

cacgctcgct tggtcctgta actattttgt agaatggaag acatcaactt tgcgtctctg 19440

gccccgcgac acggctcgcg cccgttcatg ggaaactggc aagatatcgg caccagcaat 19500

atgagcggtg gcgccttcag ctggggctcg ctgtggagcg gcattaaaaa tttcggttcc 19560

accgttaaga actatggcag caaggcctgg aacagcagca caggccagat gctgagggat 19620

aagttgaaag agcaaaattt ccaacaaaag gtggtagatg gcctggcctc tggcattagc 19680

ggggtggtgg acctggccaa ccaggcagtg caaaataaga ttaacagtaa gcttgatccc 19740

cgccctcccg tagaggagcc tccaccggcc gtggagacag tgtctccaga ggggcgtggc 19800

gaaaagcgtc cgcgccccga cagggaagaa actctggtga cgcaaataga cgagcctccc 19860

tcgtacgagg aggcactaaa gcaaggcctg cccaccaccc gtcccatcgc gcccatggct 19920

accggagtgc tgggccagca cacacccgta acgctggacc tgcctccccc cgccgacacc 19980

cagcagaaac ctgtgctgcc aggcccgacc gccgttgttg taacccgtcc tagccgcgcg 20040

tccctgcgcc gcgccgccag cggtccgcga tcgttgcggc ccgtagccag tggcaactgg 20100

caaagcacac tgaacagcat cgtgggtctg ggggtgcaat ccctgaagcg ccgacgatgc 20160

ttctgatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 20220

ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg 20280

gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 20340

gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 20400

ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc 20460

tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20520

taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20580

ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20640

aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 20700

cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20760

gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20820

tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca 20880

gtggtacgaa acagaaatta atcatgcagc tgggagagtc ctaaaaaaga ctaccccaat 20940

gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 21000

tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 21060

tgaggcagcc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 21120

tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 21180

ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 21240

ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 21300

ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 21360

ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc 21420

tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact 21480

tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa 21540

acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa 21600

tgaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21660

aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21720

caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21780

tcccgggcta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21840

caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21900

gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21960

aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 22020

catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 22080

tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 22140

tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc 22200

caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 22260

caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 22320

actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 22380

aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag 22440

ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22500

cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22560

gctagctaac tataacattg gctaccaggg cttctatatc ccagagagct acaaggaccg 22620

catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22680

atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22740

ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22800

tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct 22860

ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca 22920

aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat 22980

ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcacca 23040

gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 23100

cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 23160

gaactgaaag ccattgtcaa agatcttggt tgtggggccat attttttggg cacctatgac 23220

aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc 23280

ggtcgcgaga ctggggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 23340

tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 23400

gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg 23460

ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23520

tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23580

atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23640

ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23700

agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23760

taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23820

ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca 23880

tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23940

tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 24000

accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 24060

tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 24120

tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg 24180

ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc 24240

tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta 24300

ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 24360

tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 24420

tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24480

ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24540

acatccatt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24600

tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24660

ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc 24720

acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24780

gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24840

agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24900

cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24960

ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 25020

agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 25080

aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct 25140

ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 25200

gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 25260

tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 25320

gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt 25380

cgcgccgcac cgcgtccgcg ctcggggggtg gtttcgcgct gctcctcttc ccgactggcc 25440

atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25500

accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25560

ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25620

tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25680

gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac 25740

ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc 25800

gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac 25860

gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25920

cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25980

cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg 26040

gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 26100

gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 26160

caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac 26220

gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt 26280

aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 26340

cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 26400

gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc 26460

aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26520

gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26580

tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26640

ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 26700

gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26760

gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26820

ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac 26880

ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26940

ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 27000

ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 27060

cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 27120

tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 27180

ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 27240

atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 27300

aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 27360

cacgcccacg agattaggtt ctacgaagac caatcccgcc cgcctaatgc ggagcttacc 27420

gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27480

caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27540

ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc 27600

caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27660

ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27720

ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27780

ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac 27840

aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27900

caccactgga accaccggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27960

acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca 28020

agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 28080

cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 28140

cagcggcagc aacagcagcg gccacacaga agcaaaggcg accggatagc aagactctga 28200

caaagcccaa gaaatccaca gcggcggcag cagcaggagg aggagcgctg cgtctggcgc 28260

ccaacgaacc cgtatcgacc cgcgagctta gaaacaggat ttttcccact ctgtatgcta 28320

tatttcaaca gagcaggggc caagaacaag agctgaaaat aaaaaacagg tctctgcgat 28380

ccctcacccg cagctgcctg tatcacaaaa gcgaagatca gcttcggcgc acgctggaag 28440

acgcggaggc tctcttcagt aaatactgcg cgctgactct taaggactag tttcgcgccc 28500

tttctcaaat ttaagcgcga aaactacgtc atctccagcg gccacacccg gcgccagcac 28560

ctgttgtcag cgccattatg agcaaggaaa ttcccacgcc ctacatgtgg agttaccagc 28620

cacaaatggg acttgcggct ggagctgccc aagactactc aacccgaata aactacatga 28680

gcgcgggacc ccacatgata tcccgggtca acggaatacg cgcccaccga aaccgaattc 28740

tcctggaaca ggcggctatt accaccacac ctcgtaataa ccttaatccc cgtagttggc 28800

ccgctgccct ggtgtaccag gaaagtcccg ctcccaccac tgtggtactt cccagagacg 28860

cccaggccga agttcagatg actaactcag gggcgcagct tgcgggcggc tttcgtcaca 28920

gggtgcggtc gcccggggcag ggtataactc acctgacaat cagagggcga ggtattcagc 28980

tcaacgacga gtcggtgagc tcctcgcttg gtctccgtcc ggacgggaca tttcagatcg 29040

gcggcgccgg ccgctcttca ttcacgcctc gtcaggcaat cctaactctg cagacctcgt 29100

cctctgagcc gcgctctgga ggcattggaa ctctgcaatt tattgaggag tttgtgccat 29160

cggtctactt taaccccttc tcgggacctc ccggccacta tccggatcaa tttattccta 29220

actttgacgc ggtaaaggac tcggcggacg gctacgactg aatgttaagt ggagaggcag 29280

agcaactgcg cctgaaacac ctggtccact gtcgccgcca caagtgcttt gcccgcgact 29340

ccggtgagtt ttgctacttt gaattgcccg aggatcatat cgagggcccg gcgcacggcg 29400

tccggcttac cgcccaggga gagcttgccc gtagcctgat tcgggagttt acccagcgcc 29460

ccctgctagt tgagcgggac aggggaccct gtgttctcac tgtgatttgc aactgtccta 29520

accctggatt acatcaagat cctctagtta atgtcaggtc gcctaagtcg attaactaga 29580

gtacccgggg atcttattcc ctttaactaa taaaaaaaaa taataaagca tcacttactt 29640

aaaatcagtt agcaaatttc tgtccagttt attcagcagc acctccttgc cctcctccca 29700

gctctggtat tgcagcttcc tcctggctgc aaactttctc cacaatctaa atggaatgtc 29760

agtttcctcc tgttcctgtc catccgcacc cactatcttc atgttgttgc agatgaagcg 29820

cgcaagaccg tctgaagata ccttcaaccc cgtgtatcca tatgacacgg aaaccggtcc 29880

tccaactgtg ccttttctta ctcctccctt tgtatccccc aatgggtttc aagagagtcc 29940

ccctggggta ctctctttgc gcctatccga acctctagtt acctccaatg gcatgcttgc 30000

gctcaaaatg ggcaacggcc tctctctgga cgaggccggc aaccttacct cccaaaatgt 30060

aaccactgtg agcccacctc tcaaaaaaac caagtcaaac ataaacctgg aaatatctgc 30120

acccctcaca gttacctcag aagccctaac tgtggctgcc gccgcacctc taatggtcgc 30180

gggcaacaca ctcaccatgc aatcacaggc cccgctaacc gtgcacgact ccaaacttag 30240

cattgccacc caaggacccc tcacagtgtc agaaggaaag ctagccctgc aaacatcagg 30300

ccccctcacc accaccgata gcagtaccct tactatcact gcctcacccc ctctaactac 30360

tgccactggt agcttgggca ttgacttgaa agagcccatt tatacacaaa atggaaaact 30420

aggactaaag tacggggctc ctttgcatgt aacagacgac ctaaacactt tgaccgtagc 30480

aactggtcca ggtgtgacta ttaataatac ttccttgcaa actaaagtta ctggagcctt 30540

gggttttgat tcacaaggca atatgcaact taatgtagca ggaggactaa ggattgattc 30600

tcaaaacaga cgccttatac ttgatgttag ttatccgttt gatgctcaaa accaactaaa 30660

tctaagacta ggacagggcc ctctttttat aaactcagcc cacaacttgg atattaacta 30720

caacaaaggc ctttacttgt ttacagcttc aaacaattcc aaaaagcttg aggttaacct 30780

aagcactgcc aaggggttga tgtttgacgc tacagccata gccattaatg caggagatgg 30840

gcttgaattt ggttcaccta atgcaccaaa cacaaatccc ctcaaaacaa aaattggcca 30900

tggcctagaa tttgattcaa acaaggctat ggttcctaaa ctaggaactg gccttagttt 30960

tgacagcaca ggtgccatta cagtaggaaa caaaaataat gataagctaa ctttgtggac 31020

cggaataaac cctccaccta actngtcaaat tgtggaaaac actaatacaa atgatggcaa 31080

acttacttta gtattagtaa aaaatggagg gcttgttaat ggctacgtgt ctctagttgg 31140

tgtatcagac actgtgaacc aaatgttcac acaaaagaca gcaaacatcc aattaagatt 31200

atattttgac tcttctggaa atctattaac tgaggaatca gacttaaaaa ttccacttaa 31260

aaataaatct tctacagcga ccagtgaaac tgtagccagc agcaaagcct ttatgccaag 31320

tactacagct tatcccttca acaccactac tagggatagt gaaaactaca ttcatggaat 31380

atgttactac atgactagtt atgatagaag tctatttccc ttgaacattt ctataatgct 31440

aaacagccgt atgatttctt ccaatgttgc ctatgccata caatttgaat ggaatctaaa 31500

tgcaagtgaa tctccagaaa gcaacatagc tacgctgacc acatccccct ttttcttttc 31560

ttacattaca gaagacgaca actaaagaat cgtttgtgtt atgtttcaac gtgtttattt 31620

ttcaattgca gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata 31680

gcttatacag atcaccgtac cttaatcaaa ctcacagaac cctagtattc aacctgccac 31740

ctccctccca acacacagag tacacagtcc tttctccccg gctggcctta aaaagcatca 31800

tatcatgggt aacagacata ttcttaggtg ttatattcca cacggtttcc tgtcgagcca 31860

aacgctcatc agtgatatta ataaactccc cgggcagctc acttaagttc atgtcgctgt 31920

ccagctgctg agccacaggc tgctgtccaa cttgcggttg cttaacgggc ggcgaaggag 31980

aagtccacgc ctacatgggg gtagagtcat aatcgtgcat caggataggg cggtggtgct 32040

gcagcagcgc gcgaataaac tgctgccgcc gccgctccgt cctgcaggaa tacaacatgg 32100

cagtggtctc ctcagcgatg attcgcaccg cccgcagcat aaggcgcctt gtcctccggg 32160

cacagcagcg caccctgatc tcacttaaat cagcacagta actgcagcac agcaccacaa 32220

tattgttcaa aatcccacag tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag 32280

aacccacgtg gccatcatac cacaagcgca ggtagattaa gtggcgaccc ctcataaaca 32340

cgctggacat aaacattacc tcttttggca tgttgtaatt caccacctcc cggtaccata 32400

taaacctctg attaaacatg gcgccatcca cccacatcct aaaccagctg gccaaaacct 32460

gcccgccggc tatacactgc agggaaccgg gactggaaca atgacagtgg agagcccagg 32520

actcgtaacc atggatcatc atgctcgtca tgatatcaat gttggcacaa cacaggcaca 32580

cgtgcataca cttcctcagg attacaagct cctcccgcgt tagaaccata tcccagggaa 32640

caacccattc ctgaatcagc gtaaatccca cactgcaggg aagacctcgc acgtaactca 32700

cgttgtgcat tgtcaaagtg ttacattcgg gcagcagcgg atgatcctcc agtatggtag 32760

cgcgggtttc tgtctcaaaa ggaggtagac gatccctact gtacggagtg cgccgagaca 32820

accgagatcg tgttggtcgt agtgtcatgc caaatggaac gccggacgta gtcatatttc 32880

ctgaagcaaa accaggtgcg ggcgtgacaa acagatctgc gtctccggtc tcgccgctta 32940

gatcgctctg tgtagtagtt gtagtatatc cactctctca aagcatccag gcgccccctg 33000

gcttcgggtt ctatgtaaac tccttcatgc gccgctgccc tgataacatc caccaccgca 33060

gaataagcca cacccagcca acctacacat tcgttctgcg agtcacacac gggaggagcg 33120

ggaagagctg gaagaaccat gttttttttt ttattccaaa agattatcca aaacctcaaa 33180

atgaagatct attaagtgaa cgcgctcccc tccggtggcg tggtcaaact ctacagccaa 33240

agaacagata atggcatttg taagatgttg cacaatggct tccaaaaggc aaacggccct 33300

cacgtccaag tggacgtaaa ggctaaaccc ttcagggtga atctcctcta taaacattcc 33360

agcaccttca accatgccca aataattctc atctcgccac cttctcaata tatctctaag 33420

caaatcccga atattaagtc cggccattgt aaaaatctgc tccagagcgc cctccacctt 33480

cagcctcaag cagcgaatca tgattgcaaa aattcaggtt cctcacagac ctgtataaga 33540

ttcaaaagcg gaacattaac aaaaataccg cgatcccgta ggtcccttcg caggggccagc 33600

tgaacataat cgtgcaggtc tgcacggacc agcgcggcca cttccccgcc aggaaccatg 33660

acaaaagaac ccacactgat tatgacacgc atactcggag ctatgctaac cagcgtagcc 33720

ccgatgtaag cttgttgcat gggcggcgat ataaaatgca aggtgctgct caaaaaatca 33780

ggcaaagcct cgcgcaaaaa agaaagcaca tcgtagtcat gctcatgcag ataaaggcag 33840

gtaagctccg gaaccaccac agaaaaagac accatttttc tctcaaacat gtctgcgggt 33900

ttctgcataa acacaaaata aaataacaaa aaaacattta aacattagaa gcctgtctta 33960

caacaggaaa aacaaccctt ataagcataa gacggactac ggccatgccg gcgtgaccgt 34020

aaaaaaactg gtcaccgtga ttaaaaagca ccaccgacag ctcctcggtc atgtccggag 34080

tcataatgta agactcggta aacacatcag gttgattcac atcggtcagt gctaaaaagc 34140

gaccgaaata gcccggggga atacataccc gcaggcgtag agacaacatt acagccccca 34200

taggaggtat aacaaaatta ataggagaga aaaacacata aacacctgaa aaaccctcct 34260

gcctaggcaa aatagcaccc tcccgctcca gaacaacata cagcgcttcc acagcggcag 34320

ccataacagt cagccttacc agtaaaaaag aaaacctatt aaaaaaacac cactcgacac 34380

ggcaccagct caatcagtca cagtgtaaaa aagggccaag tgcagagcga gtatatatag 34440

gactaaaaaa tgacgtaacg gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa 34500

cctacgccca gaaacgaaag ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt 34560

tcccacgtta cgtcacttcc cattttaaga aaactacaat tcccaacaca tacaagttac 34620

tccgccctaa aacctacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc 34680

caccccctca ttatcatatt ggcttcaatc caaaataagg tatattattg atgatg 34736

<210> 28

<211> 37705

<212> DNA

<213> Artificial sequence

<220>

<223> plasmid vector #4

<400> 28

ttaattaaca tgcatggatc catatgcggt gtgaaatacc gcacagatgc gtaaggagaa 60

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 120

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag 180

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 240

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 300

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 360

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 420

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt 480

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 540

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 600

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 660

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 720

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa 780

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 840

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 900

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa 960

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt 1020

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag 1080

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca 1140

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc 1200

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt 1260

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg 1320

ttgttgccat tgctgcagcc atgagattat caaaaaggat cttcacctag atccttttca 1380

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tactgggcta 1440

tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat 1500

ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg 1560

cgccctctgg taaggttggg aagccctgca aagtaaactg gatggctttc ttgccgccaa 1620

ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca 1680

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg 1740

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag 1800

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc 1860

aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc 1920

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg 1980

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc 2040

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca 2100

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag 2160

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg 2220

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg 2280

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca 2340

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc 2400

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg 2460

acgagttctt ctgaattttg ttaaaatttt tgttaaatca gctcattttt taaccaatag 2520

gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt 2580

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga 2640

aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg 2700

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct 2760

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc 2820

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt 2880

aatgcgccgc tacagggcgc gtccattcgc cattcaggat cgaattaatt cttaattaac 2940

atcatcaata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 3000

tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 3060

atgttgcaag tgtggcggaa cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg 3120

tgtgcgccgg tgtacacagg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 3180

aaatttgggc gtaaccgagt aagatttggc cattttcgcg ggaaaactga ataagaggaa 3240

gtgaaatctg aataattttg tgttactcat agcgcgtaat actgtaatag taatcaatta 3300

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 3360

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc 3420

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa 3480

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca 3540

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta 3600

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 3660

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccatg 3720

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca 3780

actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca 3840

gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt cgacgagctc 3900

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa 3960

gacaccggga ccgatccagc ctccgatttg ccaccatgtt tgtgttcctg gtgctgctgc 4020

cactggtgtc cagccagtgt gtgaacctga ccaccaggac ccaacttcct cctgcctaca 4080

ccaactcctt caccagggga gtctactacc ctgacaaggt gttcaggtcc tctgtgctgc 4140

acagcaccca ggacctgttc ctgccattct tcagcaatgt gacctggttc catgccatcc 4200

atgtgtctgg caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg 4260

gagtctactt tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca 4320

ccctggacag caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta 4380

aggtgtgtga gttccagttc tgtaatgacc cattcctggg agtctactac cacaagaaca 4440

acaagtcctg gatggagtct gagttcaggg tctactcctc tgccaacaac tgtacctttg 4500

aatatgtgag ccaaccattc ctgatggact tggagggcaa gcagggcaac ttcaagaacc 4560

tgagggagtt tgtgttcaag aacattgatg gctacttcaa gatttacagc aaacacacac 4620

caatcaacct ggtgagggac ctgccacagg gcttctctgc cttggaacca ctggtggacc 4680

tgccaattgg catcaacatc accaggttcc agaccctgct ggctctgcac aggtcctacc 4740

tgacacctgg agactcctcc tctggctgga cagcaggagc agcagcctac tatgtgggct 4800

acctccaacc aaggaccttc ctgctgaaat acaatgagaa tggcaccatc acagatgctg 4860

tggactgtgc cctggaccca ctgtctgaga ccaagtgtac cctgaaatcc ttcacagtgg 4920

agaagggcat ctaccagacc agcaacttca gggtccaacc aacagagagc attgtgaggt 4980

ttccaaacat caccaacctg tgtccattg gagaggtgtt caatgccacc aggtttgcct 5040

ctgtctatgc ctggaacagg aagaggatta gcaactgtgt ggctgactac tctgtgctct 5100

acaactctgc ctccttcagc accttcaagt gttatggagt gagcccaacc aaactgaatg 5160

acctgtgttt caccaatgtc tatgctgact cctttgtgat taggggagat gaggtgagac 5220

agattgcccc tggacaaaca ggcaagattg ctgactacaa ctacaaactg cctgatgact 5280

tcacaggctg tgtgattgcc tggaacagca acaacctgga cagcaaggtg ggaggcaact 5340

acaactacct ctacagactg ttcaggaaga gcaacctgaa accatttgag agggacatca 5400

gcacagagat ttaccaggct ggcagcacac catgtaatgg agtggagggc ttcaactgtt 5460

actttccact ccaatcctat ggcttccaac caaccaatgg agtgggctac caaccataca 5520

gggtggtggt gctgtccttt gaactgctcc atgcccctgc cacagtgtgt ggaccaaaga 5580

agagcaccaa cctggtgaag aacaagtgtg tgaacttcaa cttcaatgga ctgacaggca 5640

caggagtgct gacagagagc aacaagaagt tcctgccatt ccaacagttt ggcagggaca 5700

ttgctgacac cacagatgct gtgagggacc cacagacctt ggagattctg gacatcacac 5760

catgttcctt tggagagtg tctgtgatta cacctggcac caacaccagc aaccaggtgg 5820

ctgtgctcta ccaggatgtg aactgtactg aggtgcctgt ggctatccat gctgaccaac 5880

ttacaccaac ctggagggtc tacagcacag gcagcaatgt gttccagacc agggctggct 5940

gtctgattgg agcagagcat gtgaacaact cctatgagtg tgacatccca attggagcag 6000

gcatctgtgc ctcctaccag acccagaccg gtggcggtgg gtcgggcggt ggtgggtcgg 6060

gtggcggcgg ttccaggtct gtggcaagcc agagcatcat tgcctacaca atgagtctgg 6120

gagcagagaa ctctgtggct tacagcaaca acagcattgc catcccaacc aacttcacca 6180

tctctgtgac cacagagatt ctgcctgtga gtatgaccaa gacctctgtg gactgtacaa 6240

tgtatatctg tggagacagc acagagtgta gcaacctgct gctccaatat ggctccttct 6300

gtacccaact taacagggct ctgacaggca ttgctgtgga acaggacaag aacacccagg 6360

aggtgtttgc ccaggtgaag cagatttaca agacacctcc aatcaaggac tttggaggct 6420

tcaacttcag ccagattctg cctgacccaa gcaagccaag caagaggtcc ttcattgagg 6480

acctgctgtt caacaaggtg accctggctg atgctggctt catcaagcaa tatggagact 6540

gtctggggaga cattgctgcc agggacctga tttgtgccca gaagttcaat ggactgacag 6600

tgctgcctcc actgctgaca gatgagatga ttgcccaata cacctctgcc ctgctggctg 6660

gcaccatcac ctctggctgg acctttggag caggagcagc cctccaaatc ccatttgcta 6720

tgcagatggc ttacaggttc aatggcattg gagtgaccca gaatgtgctc tatgagaacc 6780

agaaactgat tgccaaccag ttcaactctg ccattggcaa gattcaggac tccctgtcca 6840

gcacagcctc tgccctgggc aaactccaag atgtggtgaa ccagaatgcc caggctctga 6900

acaccctggt gaagcaactt tccagcaact ttggagccat ctcctctgtg ctgaatgaca 6960

tcctgagcag actggacaag gtggaggctg aggtccagat tgacagactg attacaggca 7020

gactccaatc cctccaaacc tatgtgaccc aacaacttat cagggctgct gagattaggg 7080

catctgccaa cctggctgcc accaagatga gtgagtgtgt gctgggacaa agcaagagg 7140

tggacttctg tggcaagggc taccacctga tgagttttcc acagtctgcc cctcatggag 7200

tggtgttcct gcatgtgacc tatgtgcctg cccaggagaa gaacttcacc acagcccctg 7260

ccatctgcca tgatggcaag gctcactttc caagggaggg agtgtttgtg agcaatggca 7320

cccactggtt tgtgacccag aggaacttct atgaaccaca gattatcacc acagacaaca 7380

cctttgtgtc tggcaactgt gatgtggtga ttggcattgt gaacaacaca gtctatgacc 7440

cactccaacc tgaactggac tccttcaagg aggaactgga caaatacttc aagaaccaca 7500

ccagccctga tgtggacctg ggagacatct ctggcatcaa tgcctctgtg gtgaacatcc 7560

agaaggagat tgacagactg aatgaggtgg ctaagaacct gaatgagtcc ctgattgacc 7620

tccaagaact gggcaaatat gaacaataca tcaagtggcc atgaaaattg atcataatca 7680

gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga 7740

acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg 7800

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt 7860

ctagttgtgg tttgtccaaa ctcatcaatg tatcttaacg cggatctggg cgtggttaag 7920

ggtgggaaag aatatataag gtggggggtct tatgtagttt tgtatctgtt ttgcagcagc 7980

cgccgccgcc atgagcacca actcgtttga tggaagcatt gtgagctcat atttgacaac 8040

gcgcatgccc ccatgggccg gggtgcgtca gaatgtgatg ggctccagca ttgatggtcg 8100

ccccgtcctg cccgcaaact ctactacctt gacctacgag accgtgtctg gaacgccgtt 8160

ggagactgca gcctccgccg ccgcttcagc cgctgcagcc accgcccgcg ggattgtgac 8220

tgactttgct ttcctgagcc cgcttgcaag cagtgcagct tcccgttcat ccgcccgcga 8280

tgacaagttg acggctcttt tggcacaatt ggattctttg acccgggaac ttaatgtcgt 8340

ttctcagcag ctgttggatc tgcgccagca ggtttctgcc ctgaaggctt cctcccctcc 8400

caatgcggtt taaaacataa ataaaaaacc agactctgtt tggatttgga tcaagcaagt 8460

gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 8520

gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 8580

atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 8640

cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 8700

gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 8760

gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 8820

gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 8880

agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 8940

cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 9000

gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 9060

ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 9120

cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 9180

cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 9240

cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 9300

gccggtgggc ccgtaaatca cacctattac cggctgcaac tggtagttaa gagagctgca 9360

gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 9420

ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 9480

agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 9540

aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 9600

atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 9660

agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 9720

acggtgaagg ggtgcgctcc gggctgcgcg ctggccagg tgcgcttgag gctggtcctg 9780

ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 9840

gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 9900

gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 9960

gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 10020

caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 10080

ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 10140

tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 10200

agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 10260

tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 10320

atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 10380

ggtgttcctg aaggggggct ataaaagggg gtggggggcgc gttcgtcctc actctcttcc 10440

gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 10500

acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 10560

gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 10620

tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 10680

agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 10740

tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 10800

acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 10860

aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 10920

tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 10980

gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 11040

gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 11100

gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 11160

gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 11220

ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 11280

tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 11340

gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 11400

accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 11460

tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 11520

tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 11580

tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 11640

tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 11700

aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 11760

gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 11820

cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 11880

ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 11940

taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 12000

gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 12060

ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 12120

aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 12180

gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 12240

agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 12300

gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 12360

tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 12420

tggtgaaagt agaagtccct gcgacggggcc gaacactcgt gctggctttt gtaaaaacgt 12480

gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 12540

cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 12600

tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 12660

accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 12720

acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 12780

gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 12840

tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 12900

cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cggggggtgtc cttggatgat 12960

gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 13020

ggagagggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 13080

ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 13140

agacgacggg cccggtgagc ttgaacctga aagagagttc gacagaatca atttcggtgt 13200

cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 13260

tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 13320

cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 13380

cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 13440

cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 13500

agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 13560

gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 13620

ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 13680

gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 13740

cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 13800

ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 13860

tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 13920

gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 13980

gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 14040

gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 14100

agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 14160

tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 14220

tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 14280

tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 14340

ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 14400

cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 14460

ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 14520

gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 14580

tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 14640

gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 14700

aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 14760

gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 14820

cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 14880

cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 14940

ggccggtcag gcgcgcgcaa tcgttgacgc tctagcgtgc aaaaggagag cctgtaagcg 15000

ggcactcttc cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt 15060

tcgagccccg tatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc 15120

caggtgtgcg acgtcagaca acgggggagt gctccttttg gcttccttcc aggcgcggcg 15180

gctgctgcgc tagctttttt ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa 15240

gcgaaagcat taagtggctc gctccctgta gccggagggt tattttccaa gggttgagtc 15300

gcgggacccc cggttcgagt ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc 15360

ccgtcatgca agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc 15420

ttttcccaga tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag 15480

caagagcagc ggcagacatg cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg 15540

acatccgcgg ttgacgcggc agcagatggt gattacgaac ccccgcggcg ccgggcccgg 15600

cactacctgg acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag 15660

cggcacccaa gggtgcagct gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac 15720

ctgtttcgcg accgcgaggg agaggagccc gaggatgc gggatcgaaa gttccacgca 15780

gggcgcgagc tgcggcatgg cctgaatcgc gagcggttgc tgcgcgagga ggactttgag 15840

cccgacgcgc gaaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta 15900

accgcatacg agcagacggt gaaccaggag attaactttc aaaaaagctt taacaaccac 15960

gtgcgtacgc ttgtggcgcg cgaggaggtg gctataggac tgatgcatct gtgggacttt 16020

gtaagcgcgc tggagcaaaa cccaaatagc aagccgctca tggcgcagct gttccttata 16080

gtgcagcaca gcagggacaa cgaggcattc agggatgcgc tgctaaacat agtagagccc 16140

gagggccgct ggctgctcga tttgataaac atcctgcaga gcatagtggt gcaggagcgc 16200

agcttgagcc tggctgacaa ggtggccgcc atcaactatt ccatgcttag cctgggcaag 16260

ttttacgccc gcaagatata ccatacccct tacgttccca tagacaagga ggtaaagatc 16320

gaggggttct acatgcgcat ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt 16380

tatcgcaacg agcgcatcca caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac 16440

cgcgagctga tgcacagcct gcaaagggcc ctggctggca cgggcagcgg cgatagagag 16500

gccgagtcct actttgacgc gggcgctgac ctgcgctggg ccccaagccg acgcgccctg 16560

gaggcagctg gggccggacc tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc 16620

ggcgtggagg aatatgacga ggacgatgag tacgagccag aggacggcga gtactaagcg 16680

gtgatgtttc tgatcagatg atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc 16740

agagccagcc gtccggcctt aactccacgg acgactggcg ccaggtcatg gaccgcatca 16800

tgtcgctgac tgcgcgcaat cctgacgcgt tccggcagca gccgcaggcc aaccggctct 16860

ccgcaattct ggaagcggtg gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg 16920

cgatcgtaaa cgcgctggcc gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct 16980

acgacgcgct gcttcagcgc gtggctcgtt acaacagcgg caacgtgcag accaacctgg 17040

accggctggt gggggatgtg cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg 17100

gcaacctggg ctccatggtt gcactaaacg ccttcctgag tacacagccc gccaacgtgc 17160

cgcggggaca ggaggactac accaactttg tgagcgcact gcggctaatg gtgactgaga 17220

caccgcaaag tgaggtgtac cagtctgggc cagactattt tttccagacc agtagacaag 17280

gcctgcagac cgtaaacctg agccaggctt tcaaaaactt gcaggggctg tggggggtgc 17340

gggctcccac aggcgaccgc gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt 17400

tgctgctgct aatagcgccc ttcacggaca gtggcagcgt gtcccgggac acatacctag 17460

gtcacttgct gacactgtac cgcgaggcca taggtcaggc gcatgtggac gagcatactt 17520

tccaggagat tacaagtgtc agccgcgcgc tggggcagga ggacacgggc agcctggagg 17580

caaccctaaa ctacctgctg accaaccggc ggcagaagat cccctcgttg cacagtttaa 17640

acagcgagga ggagcgcatt ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc 17700

gcgacggggt aacgcccagc gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca 17760

tgtatgcctc aaaccggccg tttatcaacc gcctaatgga ctacttgcat cgcgcggccg 17820

ccgtgaaccc cgagtatttc accaatgcca tcttgaaccc gcactggcta ccgccccctg 17880

gtttctacac cgggggattc gaggtgcccg agggtaacga tggattcctc tgggacgaca 17940

tagacgacag cgtgttttcc ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc 18000

aggcagaggc ggcgctgcga aaggaaagct tccgcaggcc aagcagcttg tccgatctag 18060

gcgctgcggc cccgcggtca gatgctagta gcccatttcc aagcttgata gggtctctta 18120

ccagcactcg caccacccgc ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc 18180

tgctgcagcc gcagcgcgaa aaaaacctgc ctccggcatt tcccaacaac gggatagaga 18240

gcctagtgga caagatgagt agatggaaga cgtacgcgca ggagcacagg gacgtgccag 18300

gcccgcgccc gcccacccgt cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg 18360

acgatgactc ggcagacgac agcagcgtcc tggatttggg agggagtggc aacccgtttg 18420

cgcaccttcg ccccaggctg gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata 18480

aaaaactcac caaggccatg gcaccgagcg ttggttttct tgtattcccc ttagtatgcg 18540

gcgcgcggcg atgtatgagg aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc 18600

gccagtggcg gcggcgctgg gttctccctt cgatgctccc ctggacccgc cgtttgtgcc 18660

tccgcggtac ctgcggccta ccggggggag aaacagcatc cgttactctg agttggcacc 18720

cctattcgac accacccgtg tgtacctggt ggacaacaag tcaacggatg tggcatccct 18780

gaactaccag aacgaccaca gcaactttct gaccacggtc attcaaaaca atgactacag 18840

cccgggggag gcaagcacac agaccatcaa tcttgacgac cggtcgcact ggggcggcga 18900

cctgaaaacc atcctgcata ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa 18960

gtttaaggcg cgggtgatgg tgtcgcgctt gcctactaag gacaatcagg tggagctgaa 19020

atacgagtgg gtggagttca cgctgcccga gggcaactac tccgagacca tgaccataga 19080

ccttatgaac aacgcgatcg tggagcacta cttgaaagtg ggcagacaga acggggttct 19140

ggaaagcgac atcggggtaa agtttgacac ccgcaacttc agactggggt ttgaccccgt 19200

cactggtctt gtcatgcctg gggtatatac aaacgaagcc ttccatccag acatcatttt 19260

gctgccagga tgcggggtgg acttcaccca cagccgcctg agcaacttgt tgggcatccg 19320

caagcggcaa cccttccagg agggctttag gatcacctac gatgatctgg agggtggtaa 19380

cattcccgca ctgttggatg tggacgccta ccaggcgagc ttgaaagatg acaccgaaca 19440

gggcgggggt ggcgcaggcg gcagcaacag cagtggcagc ggcgcggaag agaactccaa 19500

cgcggcagcc gcggcaatgc agccggtgga ggacatgaac gatcatgcca ttcgcggcga 19560

cacctttgcc acacgggctg aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc 19620

cgcccccgct gcgcaacccg aggtcgagaa gcctcagaag aaaccggtga tcaaacccct 19680

gacagaggac agcaagaaac gcagttacaa cctaataagc aatgacagca ccttcaccca 19740

gtaccgcagc tggtaccttg catacaacta cggcgaccct cagaccggaa tccgctcatg 19800

gaccctgctt tgcactcctg acgtaacctg cggctcggag caggtctact ggtcgttgcc 19860

agacatgatg caagaccccg tgaccttccg ctccacgcgc cagatcagca actttccggt 19920

ggtgggcgcc gagctgttgc ccgtgcactc caagagcttc tacaacgacc aggccgtcta 19980

ctcccaactc atccgccagt ttacctctct gacccacgtg ttcaatcgct ttcccgagaa 20040

ccagattttg gcgcgcccgc cagcccccac catcaccacc gtcagtgaaa acgttcctgc 20100

tctcacagat cacgggacgc taccgctgcg caacagcatc ggagagtcc agcgagtgac 20160

cattactgac gccagacgcc gcacctgccc ctacgtttac aaggccctgg gcatagtctc 20220

gccgcgcgtc ctatcgagcc gcactttttg agcaagcatg tccatcctta tatcgcccag 20280

caataacaca ggctggggcc tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg 20340

ctccgaccaa cacccagtgc gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa 20400

acgcggccgc actgggcgca ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc 20460

gcgcaactac acgcccacgc cgccaccagt gtccacagtg gacgcggcca ttcagaccgt 20520

ggtgcgcgga gcccggcgct atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg 20580

ccaccgccgc cgacccggca ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc 20640

acgtcgcacc ggccgacggg cggccatgcg ggccgctcga aggctggccg cgggtattgt 20700

cactgtgccc cccaggtcca ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc 20760

tatgactcag ggtcgcaggg gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg 20820

cgtgcccgtg cgcacccgcc ccccgcgcaa ctagattgca agaaaaaact acttagactc 20880

gtactgttgt atgtatccag cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat 20940

caaagaagag atgctccagg tcatcgcgcc ggagatctat ggccccccga agaaggaaga 21000

gcaggattac aagccccgaa agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga 21060

tgaacttgac gacgaggtgg aactgctgca cgctaccgcg cccaggcgac gggtacagtg 21120

gaaaggtcga cgcgtaaaac gtgttttgcg acccggcacc accgtagtct ttacgcccgg 21180

tgagcgctcc acccgcacct acaagcgcgt gtatgatgag gtgtacggcg acgaggacct 21240

gcttgagcag gccaacgagc gcctcgggga gtttgcctac ggaaagcggc ataaggacat 21300

gctggcgttg ccgctggacg agggcaaccc aacacctagc ctaaagcccg taacactgca 21360

gcaggtgctg cccgcgcttg caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg 21420

tgacttggca cccaccgtgc agctgatggt acccaagcgc cagcgactgg aagatgtctt 21480

ggaaaaaatg accgtggaac ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca 21540

ggtggcgccg ggactgggcg tgcagaccgt ggacgttcag atacccacta ccagtagcac 21600

cagtattgcc accgccacag agggcatgga gacacaaacg tccccggttg cctcagcggt 21660

ggcggatgcc gcggtgcagg cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca 21720

aacggacccg tggatgtttc gcgtttcagc cccccggcgc ccgcgccgtt cgaggaagta 21780

cggcgccgcc agcgcgctac tgcccgaata tgccctacat ccttccattg cgcctacccc 21840

cggctatcgt ggctacacct accgccccag aagacgagca actacccgac gccgaaccac 21900

cactggaacc cgccgccgcc gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg 21960

cagggtggct cgcgaaggag gcaggaccct ggtgctgcca acagcgcgct accaccccag 22020

catcgtttaa aagccggtct ttgtggttct tgcagatatg gccctcacct gccgcctccg 22080

tttcccggtg ccgggattcc gaggaagaat gcaccgtagg aggggcatgg ccggccacgg 22140

cctgacgggc ggcatgcgtc gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat 22200

gcgcggcggt atcctgcccc tccttattcc actgatcgcc gcggcgattg gcgccgtgcc 22260

cggaattgca tccgtggcct tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg 22320

gaaaaatcaa aataaaaagt ctggactctc acgctcgctt ggtcctgtaa ctattttgta 22380

gaatggaaga catcaacttt gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg 22440

gaaactggca agatatcggc accagcaata tgagcggtgg cgccttcagc tggggctcgc 22500

tgtggagcgg cattaaaaat ttcggttcca ccgttaagaa ctatggcagc aaggcctgga 22560

acagcagcac aggccagatg ctgagggata agttgaaaga gcaaaatttc caacaaaagg 22620

tggtagatgg cctggcctct ggcattagcg gggtggtgga cctggccaac caggcagtgc 22680

aaaataagat taacagtaag cttgatcccc gccctcccgt agaggagcct ccaccggccg 22740

tggagacagt gtctccagag gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa 22800

ctctggtgac gcaaatagac gagcctccct cgtacgagga ggcactaaag caaggcctgc 22860

ccaccacccg tcccatcgcg cccatggcta ccggagtgct gggccagcac acacccgtaa 22920

cgctggacct gcctcccccc gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg 22980

ccgttgttgt aacccgtcct agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat 23040

cgttgcggcc cgtagccagt ggcaactggc aaagcacact gaacagcatc gtgggtctgg 23100

gggtgcaatc cctgaagcgc cgacgatgct tctgatagct aacgtgtcgt atgtgtgtca 23160

tgtatgcgtc catgtcgccg ccagaggagc tgctgagccg ccgcgcgccc gctttccaag 23220

atggctaccc cttcgatgat gccgcagtgg tcttacatgc acatctcggg ccaggacgcc 23280

tcggagtacc tgagccccgg gctggtgcag tttgcccgcg ccaccgagac gtacttcagc 23340

ctgaataaca agtttagaaa ccccacggtg gcgcctacgc acgacgtgac cacagaccgg 23400

tcccagcgtt tgacgctgcg gttcatccct gtggaccgtg aggatactgc gtactcgtac 23460

aaggcgcggt tcaccctagc tgtgggtgat aaccgtgtgc tggacatggc ttccacgtac 23520

tttgacatcc gcggcgtgct ggacaggggc cctactttta agccctactc tggcactgcc 23580

tacaacgccc tggctcccaa gggtgcccca aatccttgcg aatgggatga agctgctact 23640

gctcttgaaa taaacctaga agaagaggac gatgacaacg aagacgaagt agacgagcaa 23700

gctgagcagc aaaaaactca cgtatttggg caggcgcctt attctggtat aaatattaca 23760

aaggaggta ttcaaatagg tgtcgaaggt caaacaccta aatatgccga taaaacattt 23820

caacctgaac ctcaaatagg agaatctcag tggtacgaaa cagaaattaa tcatgcagct 23880

ggggagagtcc taaaaaagac taccccaatg aaaccatgtt acggttcata tgcaaaaccc 23940

acaaatgaaa atggagggca aggcattctt gtaaagcaac aaaatggaaa gctagaaagt 24000

caagtggaaa tgcaattttt ctcaactact gaggcagccg caggcaatgg tgataacttg 24060

actcctaaag tggtattgta cagtgaagat gtagatatag aaaccccaga cactcatatt 24120

tcttacatgc ccactattaa ggaaggtaac tcacgagaac taatgggcca acaatctatg 24180

cccaacaggc ctaattacat tgcttttagg gacaatttta ttggtctaat gtattacaac 24240

agcacgggta atatgggtgt tctggcgggc caagcatcgc agttgaatgc tgttgtagat 24300

ttgcaagaca gaaacacaga gctttcatac cagcttttgc ttgattccat tggtgataga 24360

accaggtact tttctatgtg gaatcaggct gttgacagct atgatccaga tgttagaatt 24420

attgaaaatc atggaactga agatgaactt ccaaattact gctttccact gggaggtgtg 24480

attaatacag agactcttac caaggtaaaa cctaaaacag gtcaggaaaa tggatgggaa 24540

aaagatgcta cagaattttc agataaaaat gaaataagag ttggaaataa ttttgccatg 24600

gaaatcaatc taaatgccaa cctgtggaga aatttcctgt actccaacat agcgctgtat 24660

ttgcccgaca agctaaagta cagtccttcc aacgtaaaaa tttctgataa cccaaacacc 24720

tacgactaca tgaacaagcg agtggtggct cccgggctag tggactgcta cattaacctt 24780

ggagcacgct ggtcccttga ctatatggac aacgtcaacc catttaacca ccaccgcaat 24840

gctggcctgc gctaccgctc aatgttgctg ggcaatggtc gctatgtgcc cttccacatc 24900

caggtgcctc agaagttctt tgccattaaa aacctccttc tcctgccggg ctcatacacc 24960

tacgagtgga acttcaggaa ggatgttaac atggttctgc agagctccct aggaaatgac 25020

ctaagggttg acggagccag cattaagttt gatagcattt gcctttacgc caccttcttc 25080

cccatggccc acaacaccgc ctccacgctt gaggccatgc ttagaaacga caccaacgac 25140

cagtccttta acgactatct ctccgccgcc aacatgctct accctatacc cgccaacgct 25200

accaacgtgc ccatatccat cccctcccgc aactgggcgg ctttccgcgg ctgggccttc 25260

acgcgcctta agactaagga aaccccatca ctgggctcgg gctacgaccc ttattacacc 25320

tactctggct ctatacccta cctagatgga accttttacc tcaaccacac ctttaagaag 25380

gtggccatta cctttgactc ttctgtcagc tggcctggca atgaccgcct gcttaccccc 25440

aacgagtttg aaattaagcg ctcagttgac ggggagggtt acaacgttgc ccagtgtaac 25500

atgaccaaag actggttcct ggtacaaatg ctagctaact ataacattgg ctaccagggc 25560

ttctatatcc cagagagcta caaggaccgc atgtactcct tctttagaaa cttccagccc 25620

atgagccgtc aggtggtgga tgatactaaa tacaaggact accaacaggt gggcatccta 25680

caccaacaca acaactctgg atttgttggc taccttgccc caccatgcg cgaaggacag 25740

gcctaccctg ctaacttccc ctatccgctt ataggcaaga ccgcagttga cagcattacc 25800

cagaaaaagt ttctttgcga tcgcaccctt tggcgcatcc cattctccag taactttatg 25860

tccatgggcg cactcacaga cctgggccaa aaccttctct acgccaactc cgcccacgcg 25920

ctagacatga cttttgaggt ggatcccatg gacgagccca cccttcttta tgttttgttt 25980

gaagtctttg acgtggtccg tgtgcaccag ccgcaccgcg gcgtcatcga aaccgtgtac 26040

ctgcgcacgc ccttctcggc cggcaacgcc acaacataaa gaagcaagca acatcaacaa 26100

cagctgccgc catgggctcc agtgagcagg aactgaaagc cattgtcaaa gatcttggtt 26160

gtgggccata ttttttgggc acctatgaca agcgctttcc aggctttgtt tctccacaca 26220

agctcgcctg cgccatagtc aatacggccg gtcgcgagac tgggggcgta cactggatgg 26280

cctttgcctg gaacccgcac tcaaaaacat gctacctctt tgagcccttt ggcttttctg 26340

accagcgact caagcaggtt taccagtttg agtacgagtc actcctgcgc cgtagcgcca 26400

ttgcttcttc ccccgaccgc tgtataacgc tggaaaagtc cacccaaagc gtacaggggc 26460

ccaactcggc cgcctgtgga ctattctgct gcatgtttct ccacgccttt gccaactggc 26520

cccaaactcc catggatcac aaccccacca tgaaccttat taccggggta cccaactcca 26580

tgctcaacag tccccaggta cagcccaccc tgcgtcgcaa cccaggaacag ctctacagct 26640

tcctggagcg ccactcgccc tacttccgca gccacagtgc gcagattagg agcgccactt 26700

ctttttgtca cttgaaaaac atgtaaaaat aatgtactag agacactttc aataaaggca 26760

aatgctttta tttgtacact ctcgggtgat tatttacccc cacccttgcc gtctgcgccg 26820

tttaaaaatc aaaggggttc tgccgcgcat cgctatgcgc cactggcagg gacacgttgc 26880

gatactggtg tttagtgctc cacttaaact caggcacaac catccgcggc agctcggtga 26940

agttttcact ccacaggctg cgcaccatca ccaacgcgtt tagcaggtcg ggcgccgata 27000

tcttgaagtc gcagttgggg cctccgccct gcgcgcgcga gttgcgatac acagggttgc 27060

agcactggaa cactatcagc gccgggtggt gcacgctggc cagcacgctc ttgtcggaga 27120

tcagatccgc gtccaggtcc tccgcgttgc tcagggcgaa cggagtcaac tttggtagct 27180

gccttcccaa aaagggcgcg tgcccaggct ttgagttgca ctcgcaccgt agtggcatca 27240

aaaggtgacc gtgcccggtc tgggcgttag gatacagcgc ctgcataaaa gccttgatct 27300

gcttaaaagc cacctgagcc tttgcgcctt cagagaagaa catgccgcaa gacttgccgg 27360

aaaactgatt ggccggacag gccgcgtcgt gcacgcagca ccttgcgtcg gtgttggaga 27420

tctgcaccac atttcggccc caccggttct tcacgatctt ggccttgcta gactgctcct 27480

tcagcgcgcg ctgcccgttt tcgctcgtca catccattc aatcacgtgc tccttattta 27540

tcataatgct tccgtgtaga cacttaagct cgccttcgat ctcagcgcag cggtgcagcc 27600

acaacgcgca gcccgtgggc tcgtgatgct tgtaggtcac ctctgcaaac gactgcaggt 27660

acgcctgcag gaatcgcccc atcatcgtca caaaggtctt gttgctggtg aaggtcagct 27720

gcaacccgcg gtgctcctcg ttcagccagg tcttgcatac ggccgccaga gcttccactt 27780

ggtcaggcag tagtttgaag ttcgccttta gatcgttatc cacgtggtac ttgtccatca 27840

gcgcgcgcgc agcctccatg cccttctccc acgcagacac gatcggcaca ctcagcgggt 27900

tcatcaccgt aatttcactt tccgcttcgc tgggctcttc ctcttcctct tgcgtccgca 27960

taccacgcgc cactgggtcg tcttcattca gccgccgcac tgtgcgctta cctcctttgc 28020

catgcttgat tagcaccggt gggttgctga aacccaccat ttgtagcgcc acatcttctc 28080

tttcttcctc gctgtccacg attacctctg gtgatggcgg gcgctcgggc ttgggagaag 28140

ggcgcttctt tttcttcttg ggcgcaatgg ccaaatccgc cgccgaggtc gatggccgcg 28200

ggctgggtgt gcgcggcacc agcgcgtctt gtgatgagtc ttcctcgtcc tcggactcga 28260

tacgccgcct catccgcttt tttggggggcg cccggggagg cggcggcgac ggggacgggg 28320

acgacacgtc ctccatggtt gggggacgtc gcgccgcacc gcgtccgcgc tcggggggtgg 28380

tttcgcgctg ctcctcttcc cgactggcca tttccttctc ctataggcag aaaaagatca 28440

tggagtcagt cgagaagaag gacagcctaa ccgccccctc tgagttcgcc accaccgcct 28500

ccaccgatgc cgccaacgcg cctaccacct tccccgtcga ggcacccccg cttgaggagg 28560

aggaagtgat tatcgagcag gacccaggtt ttgtaagcga agacgacgag gaccgctcag 28620

taccaacaga ggataaaaag caagaccagg acaacgcaga ggcaaacgag gaacaagtcg 28680

ggcgggggga cgaaaggcat ggcgactacc tagatgtggg agacgacgtg ctgttgaagc 28740

atctgcagcg ccagtgcgcc attatctgcg acgcgttgca agagcgcagc gatgtgcccc 28800

tcgccatagc ggatgtcagc cttgcctacg aacgccacct attctcaccg cgcgtacccc 28860

ccaaacgcca agaaaacggc acatgcgagc ccaacccgcg cctcaacttc taccccgtat 28920

ttgccgtgcc agaggtgctt gccacctatc acatcttttt ccaaaactgc aagatacccc 28980

tatcctgccg tgccaaccgc agccgagcgg acaagcagct ggccttgcgg cagggcgctg 29040

tcatacctga tatcgcctcg ctcaacgaag tgccaaaaat ctttgaggt cttggacgcg 29100

acgagaagcg cgcggcaaac gctctgcaac aggaaaacag cgaaaatgaa agtcactctg 29160

gagtgttggt ggaactcgag ggtgacaacg cgcgcctagc cgtactaaaa cgcagcatcg 29220

aggtcaccca ctttgcctac ccggcactta acctaccccc caaggtcatg agcacagtca 29280

tgagtgagct gatcgtgcgc cgtgcgcagc ccctggagag ggatgcaaat ttgcaagaac 29340

aaacagagga gggcctaccc gcagttggcg acgagcagct agcgcgctgg cttcaaacgc 29400

gcgagcctgc cgacttggag gagcgacgca aactaatgat ggccgcagtg ctcgttaccg 29460

tggagcttga gtgcatgcag cggttctttg ctgacccgga gatgcagcgc aagctagagg 29520

aaacattgca ctacaccttt cgacagggct acgtacgcca ggcctgcaag atctccaacg 29580

tggagctctg caacctggtc tcctaccttg gaattttgca cgaaaaccgc cttgggcaaa 29640

acgtgcttca ttccacgctc aagggcgagg cgcgccgcga ctacgtccgc gactgcgttt 29700

acttatttct atgctacacc tggcagacgg ccatgggcgt ttggcagcag tgcttggagg 29760

agtgcaacct caaggagctg cagaaactgc taaagcaaaa cttgaaggac ctatggacgg 29820

ccttcaacga gcgctccgtg gccgcgcacc tggcggacat cattttcccc gaacgcctgc 29880

ttaaaaccct gcaacagggt ctgccagact tcaccagtca aagcatgttg cagaacttta 29940

ggaactttat cctagagcgc tcaggaatct tgcccgccac ctgctgtgca cttcctagcg 30000

actttgtgcc cattaagtac cgcgaatgcc ctccgccgct ttggggccac tgctaccttc 30060

tgcagctagc caactacctt gcctaccact ctgacataat ggaagacgtg agcggtgacg 30120

gtctactgga gtgtcactgt cgctgcaacc tatgcacccc gcaccgctcc ctggtttgca 30180

attcgcagct gcttaacgaa agtcaaatta tcggtacctt tgagctgcag ggtccctcgc 30240

ctgacgaaaa gtccgcggct ccggggttga aactcactcc ggggctgtgg acgtcggctt 30300

accttcgcaa atttgtacct gaggactacc acgcccacga gattaggttc tacgaagacc 30360

aatcccgccc gcctaatgcg gagcttaccg cctgcgtcat tacccagggc cacattcttg 30420

gccaattgca agccatcaac aaagcccgcc aagagtttct gctacgaaag ggacgggggg 30480

tttacttgga cccccagtcc ggcgaggagc tcaacccaat ccccccgccg ccgcagccct 30540

atcagcagca gccgcgggcc cttgcttccc aggatggcac ccaaaaagaa gctgcagctg 30600

ccgccgccac ccacggacga ggaggaatac tgggacagtc aggcagagga ggttttggac 30660

gaggaggagg aggacatgat ggaagactgg gagagcctag acgaggaagc ttccgaggtc 30720

gaagaggtgt cagacgaaac accgtcaccc tcggtcgcat tcccctcgcc ggcgccccag 30780

aaatcggcaa ccggttccag catggctaca acctccgctc ctcaggcgcc gccggcactg 30840

cccgttcgcc gacccaaccg tagatgggac accactggaa cccaggccgg taagtccaag 30900

cagccgccgc cgttagccca agagcaacaa cagcgccaag gctaccgctc atggcgcggg 30960

cacaagaacg ccatagttgc ttgcttgcaa gactgtgggg gcaacatctc cttcgcccgc 31020

cgctttcttc tctaccatca cggcgtggcc ttcccccgta acatcctgca ttactaccgt 31080

catctctaca gcccatactg caccggcggc agcggcagca acagcagcgg ccacacagaa 31140

gcaaaggcga ccggatagca agactctgac aaagcccaag aaatccacag cggcggcagc 31200

agcaggagga ggagcgctgc gtctggcgcc caacgaaccc gtatcgaccc gcgagcttag 31260

aaacaggatt tttcccactc tgtatgctat atttcaacag agcaggggcc aagaacaaga 31320

gctgaaaata aaaaacaggt ctctgcgatc cctcacccgc agctgcctgt atcacaaaag 31380

cgaagatcag cttcggcgca cgctggaaga cgcggaggct ctcttcagta aatactgcgc 31440

gctgactctt aaggactagt ttcgcgccct ttctcaaatt taagcgcgaa aactacgtca 31500

tctccagcgg ccacacccgg cgccagcacc tgttgtcagc gccattatga gcaaggaaat 31560

tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg gagctgccca 31620

agactactca acccgaataa actacatgag cgcgggaccc cacatgatat cccgggtcaa 31680

cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta ccaccacacc 31740

tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc 31800

tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga ctaactcagg 31860

ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg gtataactca 31920

cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct cctcgcttgg 31980

tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg 32040

tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag gcattggaac 32100

tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct cgggacctcc 32160

cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact cggcggacgg 32220

ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc tggtccactg 32280

tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg aattgcccga 32340

ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag agcttgcccg 32400

tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca ggggaccctg 32460

tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc ctctagttaa 32520

tgtcaggtcg cctaagtcga ttaactagag tacccgggga tcttattccc tttaactaat 32580

aaaaaaaaat aataaagcat cacttactta aaatcagtta gcaaatttct gtccagttta 32640

ttcagcagca cctccttgcc ctcctcccag ctctggtatt gcagcttcct cctggctgca 32700

aactttctcc acaatctaaa tggaatgtca gtttcctcct gttcctgtcc atccgcaccc 32760

actatcttca tgttgttgca gatgaagcgc gcaagaccgt ctgaagatac cttcaacccc 32820

gtgtatccat atgacacgga aaccggtcct ccaactgtgc cttttcttac tcctcccttt 32880

gtatccccca atgggtttca agagagtccc cctggggtac tctctttgcg cctatccgaa 32940

cctctagtta cctccaatgg catgcttgcg ctcaaaatgg gcaacggcct ctctctggac 33000

gaggccggca accttacctc ccaaaatgta accactgtga gcccacctct caaaaaaacc 33060

aagtcaaaca taaacctgga aatatctgca cccctcacag ttacctcaga agccctaact 33120

gtggctgccg ccgcacctct aatggtcgcg ggcaacacac tcaccatgca atcacaggcc 33180

ccgctaaccg tgcacgactc caaacttagc attgccaccc aaggacccct cacagtgtca 33240

gaaggaaagc tagccctgca aacatcaggc cccctcacca ccaccgatag cagtaccctt 33300

actatcactg cctcaccccc tctaactact gccactggta gcttgggcat tgacttgaaa 33360

gagcccattt atacacaaaa tggaaaacta ggactaaagt acggggctcc tttgcatgta 33420

agacgacc taaacacttt gaccgtagca actggtccag gtgtgactat taataatact 33480

tccttgcaaa ctaaagttac tggagccttg ggttttgatt cacaaggcaa tatgcaactt 33540

aatgtagcag gaggactaag gattgattct caaaacagac gccttatact tgatgttagt 33600

tatccgtttg atgctcaaaa ccaactaaat ctaagactag gacagggccc tcttttttata 33660

aactcagccc acaacttgga tattaactac aacaaaggcc tttacttgtt tacagcttca 33720

aacaattcca aaaagcttga ggttaaccta agcactgcca aggggttgat gtttgacgct 33780

acagccatag ccattaatgc aggagatggg cttgaatttg gttcacctaa tgcaccaaac 33840

acaaatcccc tcaaaacaaa aattggccat ggcctagaat ttgattcaaa caaggctatg 33900

gttcctaaac taggaactgg ccttagtttt gacagcacag gtgccattac agtaggaaac 33960

aaaaataatg ataagctaac tttgtggacc ggaataaacc ctccacctaa ctgtcaaatt 34020

gtggaaaaca ctaatacaaa tgatggcaaa cttactttag tattagtaaa aaatggaggg 34080

cttgttaatg gctacgtgtc tctagttggt gtatcagaca ctgtgaacca aatgttcaca 34140

caaaagacag caaacatcca attaagatta tattttgact cttctggaaa tctattaact 34200

gaggaatcag acttaaaaat tccacttaaa aataaatctt ctacagcgac cagtgaaact 34260

gtagccagca gcaaagcctt tatgccaagt actacagctt atcccttcaa caccactact 34320

agggatagtg aaaactacat tcatggaata tgttactaca tgactagtta tgatagaagt 34380

ctatttccct tgaacatttc tataatgcta aacagccgta tgatttcttc caatgttgcc 34440

tatgccatac aatttgaatg gaatctaaat gcaagtgaat ctccagaaag caacatagct 34500

acgctgacca catccccctt tttcttttct tacattacag aagacgacaa ctaaagaatc 34560

gtttgtgtta tgtttcaacg tgtttatttt tcaattgcag aaaatttcaa gtcatttttc 34620

attcagtagt atagccccac caccacatag cttatacaga tcaccgtacc ttaatcaaac 34680

tcacagaacc ctagtattca acctgccacc tccctcccaa cacacagagt acacagtcct 34740

ttctccccgg ctggccttaa aaagcatcat atcatgggta acagacatat tcttaggtgt 34800

tatattccac acggtttcct gtcgagccaa acgctcatca gtgatattaa taaactcccc 34860

gggcagctca cttaagttca tgtcgctgtc cagctgctga gccacaggct gctgtccaac 34920

ttgcggttgc ttaacgggcg gcgaaggaga agtccacgcc tacatggggg tagagtcata 34980

atcgtgcatc aggatagggc ggtggtgctg cagcagcgcg cgaataaact gctgccgccg 35040

ccgctccgtc ctgcaggaat acaacatggc agtggtctcc tcagcgatga ttcgcaccgc 35100

ccgcagcata aggcgccttg tcctccgggc acagcagcgc accctgatct cacttaaatc 35160

agcacagtaa ctgcagcaca gcaccacaat attgttcaaa atcccacagt gcaaggcgct 35220

gtatccaaag ctcatggcgg ggaccacaga acccacgtgg ccatcatacc acaagcgcag 35280

gtagattaag tggcgacccc tcataaacac gctggacata aacattacct cttttggcat 35340

gttgtaattc accacctccc ggtaccatat aaacctctga ttaaacatgg cgccatccac 35400

caccatccta aaccagctgg ccaaaacctg cccgccggct atacactgca gggaaccggg 35460

actggaacaa tgacagtgga gagcccagga ctcgtaacca tggatcatca tgctcgtcat 35520

gatatcaatg ttggcacaac acaggcacac gtgcatacac ttcctcagga ttacaagctc 35580

ctcccgcgtt agaaccatat cccagggaac aacccattcc tgaatcagcg taaatcccac 35640

actgcaggga agacctcgca cgtaactcac gttgtgcatt gtcaaagtgt tacattcggg 35700

cagcagcgga tgatcctcca gtatggtagc gcgggtttct gtctcaaaag gaggtagacg 35760

atccctactg tacggagtgc gccgagacaa ccgagatcgt gttggtcgta gtgtcatgcc 35820

aaatggaacg ccggacgtag tcatatttcc tgaagcaaaa ccaggtgcgg gcgtgacaaa 35880

cagatctgcg tctccggtct cgccgcttag atcgctctgt gtagtagttg tagtatatcc 35940

actctctcaa agcatccagg cgccccctgg cttcgggttc tatgtaaact ccttcatgcg 36000

ccgctgccct gataacatcc accaccgcag aataagccac acccagccaa cctacacatt 36060

cgttctgcga gtcacacacg ggagggagcgg gaagagctgg aagaaccatg ttttttttttt 36120

tattccaaaa gattatccaa aacctcaaaa tgaagatcta ttaagtgaac gcgctcccct 36180

ccggtggcgt ggtcaaactc tacagccaaa gaacagataa tggcatttgt aagatgttgc 36240

acaatggctt ccaaaaggca aacggccctc acgtccaagt ggacgtaaag gctaaaccct 36300

tcagggtgaa tctcctctat aaacattcca gcaccttcaa ccatgcccaa aataattctca 36360

tctcgccacc ttctcaatat atctctaagc aaatcccgaa tattaagtcc ggccattgta 36420

aaaatctgct ccagagcgcc ctccaccttc agcctcaagc agcgaatcat gattgcaaaa 36480

attcaggttc ctcacagacc tgtataagat tcaaaagcgg aacattaaca aaaataccgc 36540

gatcccgtag gtcccttcgc agggccagct gaacataatc gtgcaggtct gcacggacca 36600

gcgcggccac ttccccgcca ggaaccatga caaaagaacc cacactgatt atgacacgca 36660

tactcggagc tatgctaacc agcgtagccc cgatgtaagc ttgttgcatg ggcggcgata 36720

taaaatgcaa ggtgctgctc aaaaaatcag gcaaagcctc gcgcaaaaaa gaaagcacat 36780

cgtagtcatg ctcatgcaga taaaggcagg taagctccgg aaccaccaca gaaaaagaca 36840

ccatttttct ctcaaacatg tctgcgggtt tctgcataaa cacaaaataa aataacaaaa 36900

aaacatttaa acattagaag cctgtcttac aacaggaaaa acaaccctta taagcataag 36960

acggactacg gccatgccgg cgtgaccgta aaaaaactgg tcaccgtgat taaaaagcac 37020

caccgacagc tcctcggtca tgtccggagt cataatgtaa gactcggtaa acacatcagg 37080

ttgattcaca tcggtcagtg ctaaaaagcg accgaaatag cccgggggaa tacatacccg 37140

caggcgtaga gacaacatta cagcccccat aggaggtata acaaaattaa taggagagaa 37200

aaacacataa acacctgaaa aaccctcctg cctaggcaaa atagcaccct cccgctccag 37260

aacaacatac agcgcttcca cagcggcagc cataacagtc agccttacca gtaaaaaaga 37320

aaacctatta aaaaaacacc actcgacacg gcaccagctc aatcagtcac agtgtaaaaa 37380

agggccaagt gcagagcgag tatatatagg actaaaaaat gacgtaacgg ttaaagtcca 37440

caaaaaacac ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc 37500

acaacttcct caaatcgtca cttccgtttt cccacgttac gtcacttccc attttaagaa 37560

aactacaatt cccaacacat acaagttact ccgccctaaa acctacgtca cccgccccgt 37620

tcccacgccc cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc 37680

aaaataaggt atattattga tgatg 37705

<210> 29

<211> 34766

<212> DNA

<213> Artificial sequence

<220>

<223> vector #4

<400> 29

catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tactgtaata gtaatcaatt 360

acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 420

ggcccgcctg gctgaccgcc caacgacccc cgcccatga cgtcaataat gacgtatgtt 480

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa 540

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 600

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 660

acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 720

tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt 780

gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 840

aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 900

agagctctcc ctatcagtga tagagatctc cctatcagtg atagagatcg tcgacgagct 960

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga 1020

agacaccggg accgatccag cctccgattt gccaccatgt ttgtgttcct ggtgctgctg 1080

ccactggtgt ccagccagtg tgtgaacctg accaccagga cccaacttcc tcctgcctac 1140

accaactcct tcaccagggg agtctactac cctgacaagg tgttcaggtc ctctgtgctg 1200

cacagcaccc aggacctgtt cctgccattc ttcagcaatg tgacctggtt ccatgccatc 1260

catgtgtctg gcaccaatgg caccaagagg tttgacaacc ctgtgctgcc attcaatgat 1320

ggagtctact ttgccagcac agagaagagc aacatcatca ggggctggat ttttggcacc 1380

accctggaca gcaagacca gtccctgctg attgtgaaca atgccaccaa tgtggtgatt 1440

aaggtgtgtg agttccagtt ctgtaatgac ccattcctgg gagtctacta ccacaagaac 1500

aacaagtcct ggatggagtc tgagttcagg gtctactcct ctgccaacaa ctgtaccttt 1560

gaatatgtga gccaaccatt cctgatggac ttggagggca agcagggcaa cttcaagaac 1620

ctgagggagt ttgtgttcaa gaacattgat ggctacttca agatttacag caaacacaca 1680

ccaatcaacc tggtgaggga cctgccacag ggcttctctg ccttggaacc actggtggac 1740

ctgccaattg gcatcaacat caccaggttc cagaccctgc tggctctgca caggtcctac 1800

ctgacacctg gagactcctc ctctggctgg acagcaggag cagcagccta ctatgtgggc 1860

tacctccaac caaggacctt cctgctgaaa tacaatgaga atggcaccat cacagatgct 1920

gtggactgtg ccctggaccc actngtctgag accaagtgta ccctgaaatc cttcacagtg 1980

gagaagggca tctaccagac cagcaacttc agggtccaac caacagagag cattgtgagg 2040

tttccaaaca tcaccaacct gtgtccatt ggagaggtgt tcaatgccac caggtttgcc 2100

tctgtctatg cctggaacag gaagaggatt agcaactgtg tggctgacta ctctgtgctc 2160

tacaactctg cctccttcag caccttcaag tgttatggag tgagcccaac caaactgaat 2220

gacctgtgtt tcaccaatgt ctatgctgac tcctttgtga ttaggggaga tgaggtgaga 2280

cagattgccc ctggacaaac aggcaagatt gctgactaca actacaaact gcctgatgac 2340

ttcacaggct gtgtgattgc ctggaacagc aacaacctgg acagcaaggt gggaggcaac 2400

tacaactacc tctacagact gttcaggaag agcaacctga aaccatttga gagggacatc 2460

agcacagaga tttaccaggc tggcagcaca ccatgtaatg gagtggaggg cttcaactgt 2520

tactttccac tccaatccta tggcttccaa ccaaccaatg gagtgggcta ccaaccatac 2580

agggtggtgg tgctgtcctt tgaactgctc catgcccctg ccacagtgtg tggaccaaag 2640

aagagcacca acctggtgaa gaacaagtgt gtgaacttca acttcaatgg actgacaggc 2700

acaggagtgc tgacagagag caacaagaag ttcctgccat tccaacagtt tggcagggac 2760

attgctgaca ccacagatgc tgtgagggac ccacagacct tggagattct ggacatcaca 2820

ccatgttcct ttggaggagt gtctgtgatt acacctggca ccaacaccag caaccaggtg 2880

gctgtgctct accaggatgt gaactgtact gaggtgcctg tggctatcca tgctgaccaa 2940

cttacaccaa cctggagggt ctacagcaca ggcagcaatg tgttccagac cagggctggc 3000

tgtctgattg gagcagagca tgtgaacaac tcctatgagt gtgacatccc aattggagca 3060

ggcatctgtg cctcctacca gacccagacc ggtggcggtg ggtcgggcgg tggtgggtcg 3120

ggtggcggcg gttccaggtc tgtggcaagc cagagcatca ttgcctacac aatgagtctg 3180

ggagcagaga actctgtggc ttacagcaac aacagcattg ccatcccaac caacttcacc 3240

atctctgtga ccacagagat tctgcctgtg agtatgacca agacctctgt ggactgtaca 3300

atgtatatct gtggagacag cacagagtgt agcaacctgc tgctccaata tggctccttc 3360

tgtacccaac ttaacagggc tctgacaggc attgctgtgg aacaggacaa gaacacccag 3420

gaggtgtttg cccaggtgaa gcagatttac aagacacctc caatcaagga ctttggaggc 3480

ttcaacttca gccagattct gcctgaccca agcaagccaa gcaagaggtc cttcattgag 3540

gacctgctgt tcaacaaggt gaccctggct gatgctggct tcatcaagca atatggagac 3600

tgtctgggag acattgctgc cagggacctg atttgtgccc agaagttcaa tggactgaca 3660

gtgctgcctc cactgctgac agatgagatg attgcccaat acacctctgc cctgctggct 3720

ggcaccatca cctctggctg gacctttgga gcaggagcag ccctccaaat cccatttgct 3780

atgcagatgg cttacaggtt caatggcatt ggagtgaccc agaatgtgct ctatgagaac 3840

cagaaactga ttgccaacca gttcaactct gccattggca agattcagga ctccctgtcc 3900

agcacagcct ctgccctggg caaactccaa gatgtggtga accagaatgc ccaggctctg 3960

aacaccctgg tgaagcaact ttccagcaac tttggagcca tctcctctgt gctgaatgac 4020

atcctgagca gactggacaa ggtggaggct gaggtccaga ttgacagact gattacaggc 4080

agactccaat ccctccaaac ctatgtgacc caacaactta tcagggctgc tgagattagg 4140

gcatctgcca acctggctgc caccaagatg agtgagtgtg tgctgggaca aagcaagagg 4200

gtggacttct gtggcaaggg ctaccacctg atgagttttc cacagtctgc ccctcatgga 4260

gtggtgttcc tgcatgtgac ctatgtgcct gcccaggaga agaacttcac cacagcccct 4320

gccatctgcc atgatggcaa ggctcacttt ccaagggagg gagtgtttgt gagcaatggc 4380

acccactggt ttgtgaccca gaggaacttc tatgaaccac agattatcac cacagacaac 4440

acctttgtgt ctggcaactg tgatgtggtg attggcattg tgaacaacac agtctatgac 4500

ccactccaac ctgaactgga ctccttcaag gaggaactgg acaaatactt caagaaccac 4560

accagccctg atgtggacct gggagacatc tctggcatca atgcctctgt ggtgaacatc 4620

cagaaggaga ttgacagact gaatgaggtg gctaagaacc tgaatgagtc cctgattgac 4680

ctccaagaac tgggcaaata tgaacaatac atcaagtggc catgaaaatt gatcataatc 4740

agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg 4800

aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat 4860

ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 4920

tctagttgtg gtttgtccaa actcatcaat gtatcttaac gcggatctgg gcgtggttaa 4980

gggtgggaaa gaatatataa ggtggggggtc ttatgtagtt ttgtatctgt tttgcagcag 5040

ccgccgccgc catgagcacc aactcgtttg atggaagcat tgtgagctca tatttgacaa 5100

cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat gggctccagc attgatggtc 5160

gccccgtcct gcccgcaaac tctactacct tgacctacga gaccgtgtct ggaacgccgt 5220

tggagactgc agcctccgcc gccgcttcag ccgctgcagc caccgcccgc gggattgtga 5280

ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc ttcccgttca tccgcccgcg 5340

atgacaagtt gacggctctt ttggcacaat tggattcttt gacccgggaa cttaatgtcg 5400

tttctcagca gctgttggat ctgcgccagc aggtttctgc cctgaaggct tcctcccctc 5460

ccaatgcggt ttaaaacata aataaaaaac cagactctgt ttggatttgg atcaagcaag 5520

tgtcttgctg tctttattta ggggttttgc gcgcgcggta ggcccgggac cagcggtctc 5580

ggtcgttgag ggtcctgtgt attttttcca ggacgtggta aaggtgactc tggatgttca 5640

gatacatggg cataagcccg tctctggggt ggaggtagca ccactgcaga gcttcatgct 5700

gcggggtggt gttgtagatg atccagtcgt agcaggagcg ctgggcgtgg tgcctaaaaa 5760

tgtctttcag tagcaagctg attgccaggg gcaggccctt ggtgtaagtg tttacaaagc 5820

ggttaagctg ggatgggtgc atacgtgggg atatgagatg catcttggac tgtattttta 5880

ggttggctat gttcccagcc atatccctcc ggggattcat gttgtgcaga accaccagca 5940

cagtgtatcc ggtgcacttg ggaaatttgt catgtagctt agaaggaaat gcgtggaaga 6000

acttggagac gcccttgtga cctccaagat tttccatgca ttcgtccata atgatggcaa 6060

tgggcccacg ggcggcggcc tgggcgaaga tatttctggg atcactaacg tcatagttgt 6120

gttccaggat gagatcgtca taggccatt ttacaaagcg cgggcggagg gtgccagact 6180

gcggtataat ggttccatcc ggcccagggg cgtagttacc ctcacagatt tgcatttccc 6240

acgctttgag ttcagatggg gggatcatgt ctacctgcgg ggcgatgaag aaaacggttt 6300

ccggggtagg ggagatcagc tgggaagaaa gcaggttcct gagcagctgc gacttaccgc 6360

agccggtggg cccgtaaatc acacctatta ccggctgcaa ctggtagtta agagagctgc 6420

agctgccgtc atccctgagc aggggggcca cttcgttaag catgtccctg actcgcatgt 6480

tttccctgac caaatccgcc agaaggcgct cgccgcccag cgatagcagt tcttgcaagg 6540

aagcaaagtt tttcaacggt ttgagaccgt ccgccgtagg catgcttttg agcgtttgac 6600

caagcagttc caggcggtcc cacagctcgg tcacctgctc tacggcatct cgatccagca 6660

tatctcctcg tttcgcgggt tggggcggct ttcgctgtac ggcagtagtc ggtgctcgtc 6720

cagacgggcc agggtcatgt ctttccacgg gcgcagggtc ctcgtcagcg tagtctgggt 6780

cacggtgaag gggtgcgctc cgggctgcgc gctggccagg gtgcgcttga ggctggtcct 6840

gctggtgctg aagcgctgcc ggtcttcgcc ctgcgcgtcg gccaggtagc atttgaccat 6900

ggtgtcatag tccagcccct ccgcggcgtg gcccttggcg cgcagcttgc ccttggagga 6960

ggcgccgcac gaggggcagt gcagactttt gagggcgtag agcttgggcg cgagaaatac 7020

cgattccggg gagtaggcat ccgcgccgca ggccccgcag acggtctcgc attccacgag 7080

ccaggtgagc tctggccgtt cggggtcaaa aaccaggttt cccccatgct ttttgatgcg 7140

tttcttacct ctggtttcca tgagccggtg tccacgctcg gtgacgaaaa ggctgtccgt 7200

gtccccgtat acagacttga gaggcctgtc ctcgagcggt gttccgcggt cctcctcgta 7260

tagaaactcg gaccactctg agacaaaggc tcgcgtccag gccagcacga aggaggctaa 7320

gtgggagggg tagcggtcgt tgtccactag ggggtccact cgctccaggg tgtgaagaca 7380

catgtcgccc tcttcggcat caaggaaggt gattggtttg taggtgtagg ccacgtgacc 7440

gggtgttcct gaaggggggc tataaaaggg ggtggggggcg cgttcgtcct cactctcttc 7500

cgcatcgctg tctgcgaggg ccagctgttg gggtgagtac tccctctgaa aagcgggcat 7560

gacttctgcg ctaagattgt cagtttccaa aaacgaggag gatttgatat tcacctggcc 7620

cgcggtgatg cctttgaggg tggccgcatc catctggtca gaaaagacaa tctttttgtt 7680

gtcaagcttg gtggcaaacg acccgtagag ggcgttggac agcaacttgg cgatggagcg 7740

cagggtttgg tttttgtcgc gatcggcgcg ctccttggcc gcgatgttta gctgcacgta 7800

ttcgcgcgca acgcaccgcc attcgggaaa gacggtggtg cgctcgtcgg gcaccaggtg 7860

cacgcgccaa ccgcggttgt gcagggtgac aaggtcaacg ctggtggcta cctctccgcg 7920

taggcgctcg ttggtccagc agaggcggcc gcccttgcgc gagcagaatg gcggtagggg 7980

gtctagctgc gtctcgtccg gggggtctgc gtccacggta aagaccccgg gcagcaggcg 8040

cgcgtcgaag tagtctatct tgcatccttg caagtctagc gcctgctgcc atgcgcgggc 8100

ggcaagcgcg cgctcgtatg ggttgagtgg gggaccccat ggcatggggt gggtgagcgc 8160

ggaggcgtac atgccgcaaa tgtcgtaaac gtagaggggc tctctgagta ttccaagata 8220

tgtagggtag catcttccac cgcggatgct ggcgcgcacg taatcgtata gttcgtgcga 8280

gggagcgagg aggtcgggac cgaggttgct acgggcgggc tgctctgctc ggaagactat 8340

ctgcctgaag atggcatgtg agttggatga tatggttgga cgctggaaga cgttgaagct 8400

ggcgtctgtg agacctaccg cgtcacgcac gaaggaggcg taggagtcgc gcagcttgtt 8460

gaccagctcg gcggtgacct gcacgtctag ggcgcagtag tccagggttt ccttgatgat 8520

gtcatactta tcctgtccct tttttttcca cagctcgcgg ttgaggacaa actcttcgcg 8580

gtctttccag tactcttgga tcggaaaccc gtcggcctcc gaacggtaag agcctagcat 8640

gtagaactgg ttgacggcct ggtaggcgca gcatcccttt tctacgggta gcgcgtatgc 8700

ctgcgcggcc ttccggagcg aggtgtgggt gagcgcaaag gtgtccctga ccatgacttt 8760

gaggtactgg tatttgaagt cagtgtcgtc gcatccgccc tgctcccaga gcaaaaagtc 8820

cgtgcgcttt ttggaacgcg gatttggcag ggcgaaggtg acatcgttga agagtatctt 8880

tcccgcgcga ggcataaagt tgcgtgtgat gcggaagggt cccggcacct cggaacggtt 8940

gttaattacc tgggcggcga gcacgatctc gtcaaagccg ttgatgttgt ggcccacaat 9000

gtaaagttcc aagaagcgcg ggatgccctt gatggaaggc aattttttaa gttcctcgta 9060

ggtgagctct tcaggggagc tgagcccgtg ctctgaaagg gcccagtctg caagatgagg 9120

gttggaagcg acgaatgagc tccacaggtc acgggccatt agcatttgca ggtggtcgcg 9180

aaaggtccta aactggcgac ctatggccat tttttctggg gtgatgcagt agaaggtaag 9240

cgggtcttgt tcccagcggt cccatccaag gttcgcggct aggtctcgcg cggcagtcac 9300

tagaggctca tctccgccga acttcatgac cagcatgaag ggcacgagct gcttcccaaa 9360

ggcccccatc caagtatagg tctctacatc gtaggtgaca aagagacgct cggtgcgagg 9420

atgcgagccg atcgggaaga actggatctc ccgccaccaa ttggagggagt ggctattgat 9480

gtggtgaaag tagaagtccc tgcgacgggc cgaacactcg tgctggcttt tgtaaaaacg 9540

tgcgcagtac tggcagcggt gcacgggctg tacatcctgc acgaggttga cctgacgacc 9600

gcgcacaagg aagcagagtg ggaatttgag cccctcgcct ggcgggtttg gctggtggtc 9660

ttctacttcg gctgcttgtc cttgaccgtc tggctgctcg aggggagtta cggtggatcg 9720

gaccaccacg ccgcgcgagc ccaaagtcca gatgtccgcg cgcggcggtc ggagcttgat 9780

gacaacatcg cgcagatggg agctgtccat ggtctggagc tcccgcggcg tcaggtcagg 9840

cgggagctcc tgcaggttta cctcgcatag acgggtcagg gcgcgggcta gatccaggtg 9900

atacctaatt tccaggggct ggttggtggc ggcgtcgatg gcttgcaaga ggccgcatcc 9960

ccgcggcgcg actacggtac cgcgcggcgg gcggtgggcc gcggggggtgt ccttggatga 10020

tgcatctaaa agcggtgacg cgggcgagcc cccggaggta gggggggctc cggacccgcc 10080

gggagagggg gcaggggcac gtcggcgccg cgcgcgggca ggagctggtg ctgcgcgcgt 10140

aggttgctgg cgaacgcgac gacgcggcgg ttgatctcct gaatctggcg cctctgcgtg 10200

aagacgacgg gcccggtgag cttgaacctg aaagagagtt cgacagaatc aatttcggtg 10260

tcgttgacgg cggcctggcg caaaatctcc tgcacgtctc ctgagttgtc ttgataggcg 10320

atctcggcca tgaactgctc gatctcttcc tcctggagat ctccgcgtcc ggctcgctcc 10380

acggtggcgg cgaggtcgtt ggaaatgcgg gccatgagct gcgagaaggc gttgaggcct 10440

ccctcgttcc agacgcggct gtagaccacg cccccttcgg catcgcgggc gcgcatgacc 10500

acctgcgcga gattgagctc cacgtgccgg gcgaagacgg cgtagtttcg caggcgctga 10560

aagaggtagt tgaggtggt ggcggtgtgt tctgccacga agaagtacat aacccagcgt 10620

cgcaacgtgg attcgttgat atcccccaag gcctcaaggc gctccatggc ctcgtagaag 10680

tccacggcga agttgaaaaa ctgggagttg cgcgccgaca cggttaactc ctcctccaga 10740

agacggatga gctcggcgac agtgtcgcgc acctcgcgct caaaggctac aggggcctct 10800

tcttcttctt caatctcctc ttccataagg gcctcccctt cttcttcttc tggcggcggt 10860

gggggagggg ggacacggcg gcgacgacgg cgcaccggga ggcggtcgac aaagcgctcg 10920

atcatctccc cgcggcgacg gcgcatggtc tcggtgacgg cgcggccgtt ctcgcggggg 10980

cgcagttgga agacgccgcc cgtcatgtcc cggttatggg ttggcggggg gctgccatgc 11040

ggcagggata cggcgctaac gatgcatctc aacaattgtt gtgtaggtac tccgccgccg 11100

agggacctga gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa ggcgtctaac 11160

cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg gcagcgggcg gcggtcgggg 11220

ttgtttctgg cggaggtgct gctgatgatg taattaaagt aggcggtctt gagacggcgg 11280

atggtcgaca gaagcaccat gtccttgggt ccggcctgct gaatgcgcag gcggtcggcc 11340

atgccccagg cttcgttttg acatcggcgc aggtctttgt agtagtcttg catgagcctt 11400

tctaccggca cttcttcttc tccttcctct tgtcctgcat ctcttgcatc tatcgctgcg 11460

gcggcggcgg agtttggccg taggtggcgc cctcttcctc ccatgcgtgt gaccccgaag 11520

cccctcatcg gctgaagcag ggctaggtcg gcgacaacgc gctcggctaa tatggcctgc 11580

tgcacctgcg tgaggtaga ctggaagtca tccatgtcca caaagcggtg gtatgcgccc 11640

gtgttgatgg tgtaagtgca gttggccata acggaccagt taacggtctg gtgacccggc 11700

tgcgagagct cggtgtacct gagacgcgag taagccctcg agtcaaatac gtagtcgttg 11760

caagtccgca ccaggtactg gtatcccacc aaaaagtgcg gcggcggctg gcggtagagg 11820

ggccagcgta gggtggccgg ggctccgggg gcgagatctt ccaacataag gcgatgatat 11880

ccgtagatgt acctggacat ccaggtgatg ccggcggcgg tggtggaggc gcgcggaaag 11940

tcgcggacgc ggttccagat gttgcgcagc ggcaaaaagt gctccatggt cgggacgctc 12000

tggccggtca ggcgcgcgca atcgttgacg ctctagcgtg caaaaggaga gcctgtaagc 12060

gggcactctt ccgtggtctg gtggataaat tcgcaagggt atcatggcgg acgaccgggg 12120

ttcgagcccc gtatccggcc gtccgccgtg atccatgcgg ttaccgcccg cgtgtcgaac 12180

ccaggtgtgc gacgtcagac aacgggggag tgctcctttt ggcttccttc caggcgcggc 12240

ggctgctgcg ctagcttttt tggccactgg ccgcgcgcag cgtaagcggt taggctggaa 12300

agcgaaagca ttaagtggct cgctccctgt agccggaggg ttattttcca agggttgagt 12360

cgcgggaccc ccggttcgag tctcggaccg gccggactgc ggcgaacggg ggtttgcctc 12420

cccgtcatgc aagaccccgc ttgcaaattc ctccggaaac agggacgagc cccttttttg 12480

cttttcccag atgcatccgg tgctgcggca gatgcgcccc cctcctcagc agcggcaaga 12540

gcaagagcag cggcagacat gcagggcacc ctcccctcct cctaccgcgt caggaggggc 12600

gacatccgcg gttgacgcgg cagcagatgg tgattacgaa cccccgcggc gccgggcccg 12660

gcactacctg gacttggagg agggcgaggg cctggcgcgg ctaggagcgc cctctcctga 12720

gcggcaccca agggtgcagc tgaagcgtga tacgcgtgag gcgtacgtgc cgcggcagaa 12780

cctgtttcgc gaccgcgagg gagaggagcc cgaggagatg cgggatcgaa agttccacgc 12840

agggcgcgag ctgcggcatg gcctgaatcg cgagcggttg ctgcgcgagg aggactttga 12900

gcccgacgcg cgaaccggga ttagtcccgc gcgcgcacac gtggcggccg ccgacctggt 12960

aaccgcatac gagcagacgg tgaaccagga gattaacttt caaaaaagct ttaacaacca 13020

cgtgcgtacg cttgtggcgc gcgaggaggt ggctatagga ctgatgcatc tgtgggactt 13080

tgtaagcgcg ctggagcaaa acccaaatag caagccgctc atggcgcagc tgttccttat 13140

agtgcagcac agcagggaca acgaggcatt cagggatgcg ctgctaaaca tagtagagcc 13200

cgaggggccgc tggctgctcg atttgataaa catcctgcag agcatagtgg tgcaggagcg 13260

cagcttgagc ctggctgaca aggtggccgc catcaactat tccatgctta gcctgggcaa 13320

gttttacgcc cgcaagatat accatacccc ttacgttccc atagacaagg aggtaaagat 13380

cgaggggttc tacatgcgca tggcgctgaa ggtgcttacc ttgagcgacg acctgggcgt 13440

ttatcgcaac gagcgcatcc acaaggccgt gagcgtgagc cggcggcgcg agctcagcga 13500

ccgcgagctg atgcacagcc tgcaaagggc cctggctggc acgggcagcg gcgatagaga 13560

ggccgagtcc tactttgacg cgggcgctga cctgcgctgg gccccaagcc gacgcgccct 13620

ggaggcagct ggggccggac ctgggctggc ggtggcaccc gcgcgcgctg gcaacgtcgg 13680

cggcgtggag gaatatgacg aggacgatga gtacgagcca gaggacggcg agtactaagc 13740

ggtgatgttt ctgatcagat gatgcaagac gcaacggacc cggcggtgcg ggcggcgctg 13800

cagagccagc cgtccggcct taactccacg gacgactggc gccaggtcat ggaccgcatc 13860

atgtcgctga ctgcgcgcaa tcctgacgcg ttccggcagc agccgcaggc caaccggctc 13920

tccgcaattc tggaagcggt ggtcccggcg cgcgcaaacc ccacgcacga gaaggtgctg 13980

gcgatcgtaa acgcgctggc cgaaaacagg gccatccggc ccgacgaggc cggcctggtc 14040

tacgacgcgc tgcttcagcg cgtggctcgt tacaacagcg gcaacgtgca gaccaacctg 14100

gaccggctgg tgggggatgt gcgcgaggcc gtggcgcagc gtgagcgcgc gcagcagcag 14160

ggcaacctgg gctccatggt tgcactaaac gccttcctga gtacacagcc cgccaacgtg 14220

ccgcggggac aggaggacta caccaacttt gtgagcgcac tgcggctaat ggtgactgag 14280

acaccgcaaa gtgaggtgta ccagtctggg ccagactatt ttttccagac cagtagacaa 14340

ggcctgcaga ccgtaaacct gagccaggct ttcaaaaact tgcaggggct gtggggggtg 14400

cgggctccca caggcgaccg cgcgaccgtg tctagcttgc tgacgcccaa ctcgcgcctg 14460

ttgctgctgc taatagcgcc cttcacggac agtggcagcg tgtcccggga cacataccta 14520

ggtcacttgc tgacactgta ccgcgaggcc ataggtcagg cgcatgtgga cgagcatact 14580

ttccaggaga ttacaagtgt cagccgcgcg ctggggcagg aggacacggg cagcctggag 14640

gcaaccctaa actacctgct gaccaaccgg cggcagaaga tcccctcgtt gcacagttta 14700

aacagcgagg aggagcgcat tttgcgctac gtgcagcaga gcgtgagcct taacctgatg 14760

cgcgacgggg taacgcccag cgtggcgctg gacatgaccg cgcgcaacat ggaaccgggc 14820

atgtatgcct caaaccggcc gtttatcaac cgcctaatgg actacttgca tcgcgcggcc 14880

gccgtgaacc ccgagtattt caccaatgcc atcttgaacc cgcactggct accgccccct 14940

ggtttctaca ccgggggatt cgaggtgccc gagggtaacg atggattcct ctgggacgac 15000

atagacgaca gcgtgttttc cccgcaaccg cagaccctgc tagagttgca acagcgcgag 15060

caggcagagg cggcgctgcg aaaggaaagc ttccgcaggc caagcagctt gtccgatcta 15120

ggcgctgcgg ccccgcggtc agatgctagt agcccatttc caagcttgat agggtctctt 15180

accagcactc gcaccacccg cccgcgcctg ctgggcgagg aggagtacct aaacaactcg 15240

ctgctgcagc cgcagcgcga aaaaaacctg cctccggcat ttcccaacaa cgggatagag 15300

agcctagtgg acaagatgag tagatggaag acgtacgcgc aggagcacag ggacgtgcca 15360

ggcccgcgcc cgcccacccg tcgtcaaagg cacgaccgtc agcggggtct ggtgtggggag 15420

gacgatgact cggcagacga cagcagcgtc ctggatttgg gagggagtgg caacccgttt 15480

gcgcaccttc gccccaggct ggggagaatg ttttaaaaaa aaaaaagcat gatgcaaaat 15540

aaaaaactca ccaaggccat ggcaccgagc gttggttttc ttgtattccc cttagtatgc 15600

ggcgcgcggc gatgtatgag gaaggtcctc ctccctccta cgagagtgtg gtgagcgcgg 15660

cgccagtggc ggcggcgctg ggttctccct tcgatgctcc cctggacccg ccgtttgtgc 15720

ctccgcggta cctgcggcct accgggggga gaaacagcat ccgttactct gagttggcac 15780

ccctattcga caccacccgt gtgtacctgg tggacaacaa gtcaacggat gtggcatccc 15840

tgaactacca gaacgaccac agcaactttc tgaccacggt cattcaaaac aatgactaca 15900

gcccggggga ggcaagcaca cagaccatca atcttgacga ccggtcgcac tggggcggcg 15960

acctgaaaac catcctgcat accaacatgc caaatgtgaa cgagttcatg tttaccaata 16020

agtttaaggc gcgggtgatg gtgtcgcgct tgcctactaa ggacaatcag gtggagctga 16080

aatacgagtg ggtggagttc acgctgcccg agggcaacta ctccgagacc atgaccatag 16140

accttatgaa caacgcgatc gtggagcact acttgaaagt gggcagacag aacggggttc 16200

tggaaagcga catcggggta aagtttgaca cccgcaactt cagactgggg tttgaccccg 16260

tcactggtct tgtcatgcct ggggtatata caaacgaagc cttccatcca gacatcattt 16320

tgctgccagg atgcggggtg gacttcaccc acagccgcct gagcaacttg ttgggcatcc 16380

gcaagcggca acccttccag gagggcttta ggatcaccta cgatgatctg gagggtggta 16440

acattcccgc actgttggat gtggacgcct accaggcgag cttgaaagat gacaccgaac 16500

agggcggggg tggcgcaggc ggcagcaaca gcagtggcag cggcgcggaa gagaactcca 16560

acgcggcagc cgcggcaatg cagccggtgg aggacatgaa cgatcatgcc attcgcggcg 16620

acacctttgc cacacggggct gaggagaagc gcgctgaggc cgaagcagcg gccgaagctg 16680

ccgcccccgc tgcgcaaccc gaggtcgaga agcctcagaa gaaaccggtg atcaaacccc 16740

tgacagagga cagcaagaaa cgcagttaca acctaataag caatgacagc accttcaccc 16800

agtaccgcag ctggtacctt gcatacaact acggcgaccc tcagaccgga atccgctcat 16860

ggaccctgct ttgcactcct gacgtaacct gcggctcgga gcaggtctac tggtcgttgc 16920

cagacatgat gcaagacccc gtgaccttcc gctccacgcg cgagatcagc aactttccgg 16980

tggtgggcgc cgagctgttg cccgtgcact ccaagagctt ctacaacgac caggccgtct 17040

actcccaact catccgccag tttacctctc tgacccacgt gttcaatcgc tttcccgaga 17100

accagattt ggcgcgcccg ccagccccca ccatcaccac cgtcagtgaa aacgttcctg 17160

ctctcacaga tcacgggacg ctaccgctgc gcaacagcat cggagggagtc cagcgagtga 17220

ccattactga cgccagacgc cgcacctgcc cctacgttta caaggccctg ggcatagtct 17280

cgccgcgcgt cctatcgagc cgcacttttt gagcaagcat gtccatcctt atatcgccca 17340

gcaataacac aggctggggc ctgcgcttcc caagcaagat gtttggcggg gccaagaagc 17400

gctccgacca acacccagtg cgcgtgcgcg ggcactaccg cgcgccctgg ggcgcgcaca 17460

aacgcggccg cactgggcgc accaccgtcg atgacgccat cgacgcggtg gtggaggagg 17520

cgcgcaacta cacgcccacg ccgccaccag tgtccacagt ggacgcggcc attcagaccg 17580

tggtgcgcgg agcccggcgc tatgctaaaa tgaagagacg gcggaggcgc gtagcacgtc 17640

gccaccgccg ccgacccggc actgccgccc aacgcgcggc ggcggccctg cttaaccgcg 17700

cacgtcgcac cggccgacgg gcggccatgc gggccgctcg aaggctggcc gcgggtattg 17760

tcactgtgcc ccccaggtcc aggcgacgag cggccgccgc agcagccgcg gccattagtg 17820

ctatgactca gggtcgcagg ggcaacgtgt attgggtgcg cgactcggtt agcggcctgc 17880

gcgtgcccgt gcgcacccgc cccccgcgca actagattgc aagaaaaaac tacttagact 17940

cgtactgttg tatgtatcca gcggcggcgg cgcgcaacga agctatgtcc aagcgcaaaa 18000

tcaaagaaga gatgctccag gtcatcgcgc cggagatcta tggccccccg aagaaggaag 18060

agcaggatta caagccccga aagctaaagc gggtcaaaaa gaaaaagaaa gatgatgatg 18120

atgaacttga cgacgaggtg gaactgctgc acgctaccgc gcccaggcga cgggtacagt 18180

ggaaaggtcg acgcgtaaaa cgtgttttgc gacccggcac caccgtagtc tttacgcccg 18240

gtgagcgctc cacccgcacc tacaagcgcg tgtatgatga ggtgtacggc gacgaggacc 18300

tgcttgagca ggccaacgag cgcctcgggg agtttgccta cggaaagcgg cataaggaca 18360

tgctggcgtt gccgctggac gagggcaacc caacacctag cctaaagccc gtaacactgc 18420

agcaggtgct gcccgcgctt gcaccgtccg aagaaaagcg cggcctaaag cgcgagtctg 18480

gtgacttggc acccaccgtg cagctgatgg tacccaagcg ccagcgactg gaagatgtct 18540

tggaaaaaat gaccgtggaa cctgggctgg agcccgaggt ccgcgtgcgg ccaatcaagc 18600

aggtggcgcc gggactgggc gtgcagaccg tggacgttca gatacccact accagtagca 18660

ccagtattgc caccgccaca gagggcatgg agacacaaac gtccccggtt gcctcagcgg 18720

tggcggatgc cgcggtgcag gcggtcgctg cggccgcgtc caagacctct acggaggtgc 18780

aaacggaccc gtggatgttt cgcgtttcag ccccccggcg cccgcgccgt tcgaggaagt 18840

acggcgccgc cagcgcgcta ctgcccgaat atgccctaca tccttccatt gcgcctaccc 18900

ccggctatcg tggctacacc taccgcccca gaagacgagc aactacccga cgccgaacca 18960

ccactggaac ccgccgccgc cgtcgccgtc gccagcccgt gctggccccg atttccgtgc 19020

gcagggtggc tcgcgaagga ggcaggaccc tggtgctgcc aacagcgcgc taccacccca 19080

gcatcgttta aaagccggtc tttgtggttc ttgcagatat ggccctcacc tgccgcctcc 19140

gtttcccggt gccgggattc cgaggaagaa tgcaccgtag gaggggcatg gccggccacg 19200

gcctgacggg cggcatgcgt cgtgcgcacc accggcggcg gcgcgcgtcg caccgtcgca 19260

tgcgcggcgg tatcctgccc ctccttattc cactgatcgc cgcggcgatt ggcgccgtgc 19320

ccggaattgc atccgtggcc ttgcaggcgc agagacactg attaaaaaca agttgcatgt 19380

ggaaaaatca aaataaaaag tctggactct cacgctcgct tggtcctgta actattttgt 19440

agaatggaag acatcaactt tgcgtctctg gccccgcgac acggctcgcg cccgttcatg 19500

ggaaactggc aagatatcgg caccagcaat atgagcggtg gcgccttcag ctggggctcg 19560

ctgtggagcg gcattaaaaa tttcggttcc accgttaaga actatggcag caaggcctgg 19620

aacagcagca caggccagat gctgagggat aagttgaaag agcaaaattt ccaacaaaag 19680

gtggtagatg gcctggcctc tggcattagc ggggtggtgg acctggccaa ccaggcagtg 19740

caaaataaga ttaacagtaa gcttgatccc cgccctcccg tagagggagcc tccaccggcc 19800

gtggagacag tgtctccaga ggggcgtggc gaaaagcgtc cgcgccccga cagggaagaa 19860

actctggtga cgcaaataga cgagcctccc tcgtacgagg aggcactaaa gcaaggcctg 19920

cccaccaccc gtcccatcgc gcccatggct accggagtgc tgggccagca cacacccgta 19980

acgctggacc tgcctccccc cgccgacacc cagcagaaac ctgtgctgcc aggcccgacc 20040

gccgttgttg taacccgtcc tagccgcgcg tccctgcgcc gcgccgccag cggtccgcga 20100

tcgttgcggc ccgtagccag tggcaactgg caaagcacac tgaacagcat cgtgggtctg 20160

ggggtgcaat ccctgaagcg ccgacgatgc ttctgatagc taacgtgtcg tatgtgtgtc 20220

atgtatgcgt ccatgtcgcc gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa 20280

gatggctacc ccttcgatga tgccgcagtg gtcttacatg cacatctcgg gccaggacgc 20340

ctcggagtac ctgagccccg ggctggtgca gtttgcccgc gccaccgaga cgtacttcag 20400

cctgaataac aagtttagaa accccacggt ggcgcctacg cacgacgtga ccacagaccg 20460

gtcccagcgt ttgacgctgc ggttcatccc tgtggaccgt gaggatactg cgtactcgta 20520

caaggcgcgg ttcaccctag ctgtgggtga taaccgtgtg ctggacatgg cttccacgta 20580

ctttgacatc cgcggcgtgc tggacagggg ccctactttt aagccctact ctggcactgc 20640

ctacaacgcc ctggctccca agggtgcccc aaatccttgc gaatgggatg aagctgctac 20700

tgctcttgaa ataaacctag aagaagagga cgatgacaac gaagacgaag tagacgagca 20760

agctgagcag caaaaaactc acgtatttgg gcaggcgcct tattctggta taaatattac 20820

aaaggagggt attcaaatag gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt 20880

tcaacctgaa cctcaaatag gagaatctca gtggtacgaa acagaaatta atcatgcagc 20940

tggggagagtc ctaaaaaaga ctaccccaat gaaaccatgt tacggttcat atgcaaaacc 21000

cacaaatgaa aatggagggc aaggcattct tgtaaagcaa caaaatggaa agctagaaag 21060

tcaagtggaa atgcaatttt tctcaactac tgaggcagcc gcaggcaatg gtgataactt 21120

gactcctaaa gtggtattgt acagtgaaga tgtagatata gaaaccccag acactcatat 21180

ttcttacatg cccactatta aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat 21240

gcccaacagg cctaattaca ttgcttttag ggacaatttt attggtctaa tgtattacaa 21300

cagcacgggt aatatgggtg ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga 21360

tttgcaagac agaaacacag agctttcata ccagcttttg cttgattcca ttggtgatag 21420

aaccaggtac ttttctatgt ggaatcaggc tgttgacagc tatgatccag atgttagaat 21480

tattgaaaat catggaactg aagatgaact tccaaattac tgctttccac tgggaggtgt 21540

gattaataca gagactctta ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga 21600

aaaagatgct acagaatttt cagataaaaa tgaaataaga gttggaaata attttgccat 21660

ggaaatcaat ctaaatgcca acctgtggag aaatttcctg tactccaaca tagcgctgta 21720

tttgcccgac aagctaaagt acagtccttc caacgtaaaa atttctgata acccaaacac 21780

ctacgactac atgaacaagc gagtggtggc tcccgggcta gtggactgct acattaacct 21840

tggagcacgc tggtcccttg actatatgga caacgtcaac ccatttaacc accaccgcaa 21900

tgctggcctg cgctaccgct caatgttgct gggcaatggt cgctatgtgc ccttccacat 21960

ccaggtgcct cagaagttct ttgccattaa aaacctcctt ctcctgccgg gctcatacac 22020

ctacgagtgg aacttcagga aggatgttaa catggttctg cagagctccc taggaaatga 22080

cctaagggtt gacggagcca gcattaagtt tgatagcatt tgcctttacg ccaccttctt 22140

ccccatggcc cacaacaccg cctccacgct tgaggccatg cttagaaacg acaccaacga 22200

ccagtccttt aacgactatc tctccgccgc caacatgctc taccctatac ccgccaacgc 22260

taccaacgtg cccatatcca tcccctcccg caactgggcg gctttccgcg gctgggcctt 22320

cacgcgcctt aagactaagg aaaccccatc actgggctcg ggctacgacc cttattacac 22380

ctactctggc tctataccct acctagatgg aaccttttac ctcaaccaca cctttaagaa 22440

ggtggccatt acctttgact cttctgtcag ctggcctggc aatgaccgcc tgcttacccc 22500

caacgagttt gaaattaagc gctcagttga cggggagggt tacaacgttg cccagtgtaa 22560

catgaccaaa gactggttcc tggtacaaat gctagctaac tataacattg gctaccaggg 22620

cttctatatc ccagagagct acaaggaccg catgtactcc ttctttagaa acttccagcc 22680

catgagccgt caggtggtgg atgatactaa atacaaggac taccaacagg tgggcatcct 22740

acaccaacac aacaactctg gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca 22800

ggcctaccct gctaacttcc cctatccgct tataggcaag accgcagttg acagcattac 22860

ccagaaaaag tttctttgcg atcgcaccct ttggcgcatc ccattctcca gtaactttat 22920

gtccatgggc gcactcacag acctgggcca aaaccttctc tacgccaact ccgcccacgc 22980

gctagacatg acttttgagg tggatcccat ggacgagccc acccttcttt atgttttgtt 23040

tgaagtcttt gacgtggtcc gtgtgcacca gccgcaccgc ggcgtcatcg aaaccgtgta 23100

cctgcgcacg cccttctcgg ccggcaacgc cacaacataa agaagcaagc aacatcaaca 23160

acagctgccg ccatgggctc cagtgagcag gaactgaaag ccattgtcaa agatcttggt 23220

tgtgggccat attttttggg cacctatgac aagcgctttc caggctttgt ttctccacac 23280

aagctcgcct gcgccatagt caatacggcc ggtcgcgaga ctggggggcgt acactggatg 23340

gcctttgcct ggaacccgca ctcaaaaaca tgctacctct ttgagccctt tggcttttct 23400

gaccagcgac tcaagcaggt ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc 23460

attgcttctt cccccgaccg ctgtataacg ctggaaaagt ccacccaaag cgtacagggg 23520

cccaactcgg ccgcctgtgg actattctgc tgcatgtttc tccacgcctt tgccaactgg 23580

ccccaaactc ccatggatca caaccccacc atgaacctta ttaccggggt acccaactcc 23640

atgctcaaca gtccccaggt acagcccacc ctgcgtcgca accaggaaca gctctacagc 23700

ttcctggagc gccactcgcc ctacttccgc agccacagtg cgcagattag gagcgccact 23760

tctttttgtc acttgaaaaa catgtaaaaa taatgtacta gagacacttt caataaaggc 23820

aaatgctttt atttgtacac tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc 23880

gtttaaaaat caaaggggtt ctgccgcgca tcgctatgcg ccactggcag ggacacgttg 23940

cgatactggt gtttagtgct ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg 24000

aagttttcac tccacaggct gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat 24060

atcttgaagt cgcagttggg gcctccgccc tgcgcgcgcg agttgcgata cacaggttg 24120

cagcactgga acactatcag cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag 24180

atcagatccg cgtccaggtc ctccgcgttg ctcagggcga acggagtcaa ctttggtagc 24240

tgccttccca aaaagggcgc gtgcccaggc tttgagttgc actcgcaccg tagtggcatc 24300

aaaaggtgac cgtgcccggt ctgggcgtta ggatacagcg cctgcataaa agccttgatc 24360

tgcttaaaag ccacctgagc ctttgcgcct tcagagaaga acatgccgca agacttgccg 24420

gaaaactgat tggccggaca ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag 24480

atctgcacca catttcggcc ccaccggttc ttcacgatct tggccttgct agactgctcc 24540

ttcagcgcgc gctgcccgtt ttcgctcgtc acatccattt caatcacgtg ctccttattt 24600

atcataatgc ttccgtgtag acacttaagc tcgccttcga tctcagcgca gcggtgcagc 24660

cacaacgcgc agcccgtggg ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg 24720

tacgcctgca ggaatcgccc catcatcgtc acaaaggtct tgttgctggt gaaggtcagc 24780

tgcaacccgc ggtgctcctc gttcagccag gtcttgcata cggccgccag agcttccact 24840

tggtcaggca gtagtttgaa gttcgccttt agatcgttat ccacgtggta cttgtccatc 24900

agcgcgcgcg cagcctccat gcccttctcc cacgcagaca cgatcggcac actcagcggg 24960

ttcatcaccg taatttcact ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc 25020

ataccacgcg ccactgggtc gtcttcattc agccgccgca ctgtgcgctt acctcctttg 25080

ccatgcttga ttagcaccgg tgggttgctg aaacccacca tttgtagcgc cacatcttct 25140

ctttcttcct cgctgtccac gattacctct ggtgatggcg ggcgctcggg cttggggagaa 25200

gggcgcttct ttttcttctt gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc 25260

gggctgggtg tgcgcggcac cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg 25320

atacgccgcc tcatccgctt ttttgggggc gcccggggag gcggcggcga cggggacggg 25380

gacgacacgt cctccatggt tgggggacgt cgcgccgcac cgcgtccgcg ctcggggggtg 25440

gtttcgcgct gctcctcttc ccgactggcc atttccttct cctataggca gaaaaagatc 25500

atggagtcag tcgagaagaa ggacagccta accgccccct ctgagttcgc caccaccgcc 25560

tccaccgatg ccgccaacgc gcctaccacc ttccccgtcg aggcaccccc gcttgaggag 25620

gaggaagtga ttatcgagca ggacccaggt tttgtaagcg aagacgacga ggaccgctca 25680

gtaccaacag aggataaaaa gcaagaccag gacaacgcag aggcaaacga ggaacaagtc 25740

gggcgggggg acgaaaggca tggcgactac ctagatgtgg gagacgacgt gctgttgaag 25800

catctgcagc gccagtgcgc cattatctgc gacgcgttgc aagagcgcag cgatgtgccc 25860

ctcgccatag cggatgtcag ccttgcctac gaacgccacc tattctcacc gcgcgtaccc 25920

cccaaacgcc aagaaaacgg cacatgcgag cccaacccgc gcctcaactt ctaccccgta 25980

tttgccgtgc cagaggtgct tgccacctat cacatctttt tccaaaactg caagataccc 26040

ctatcctgcc gtgccaaccg cagccgagcg gacaagcagc tggccttgcg gcagggcgct 26100

gtcatacctg atatcgcctc gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc 26160

gacgagaagc gcgcggcaaa cgctctgcaa caggaaaaca gcgaaaatga aagtcactct 26220

ggagtgttgg tggaactcga gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc 26280

gaggtcaccc actttgccta cccggcactt aacctacccc ccaaggtcat gagcacagtc 26340

atgagtgagc tgatcgtgcg ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa 26400

caaacagagg agggcctacc cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg 26460

cgcgagcctg ccgacttgga ggagcgacgc aaactaatga tggccgcagt gctcgttacc 26520

gtggagcttg agtgcatgca gcggttcttt gctgacccgg agatgcagcg caagctagag 26580

gaaacattgc actacacctt tcgacagggc tacgtacgcc aggcctgcaa gatctccaac 26640

gtggagctct gcaacctggt ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa 26700

aacgtgcttc attccacgct caagggcgag gcgcgccgcg actacgtccg cgactgcgtt 26760

tacttatttc tatgctacac ctggcagacg gccatgggcg tttggcagca gtgcttggag 26820

gagtgcaacc tcaaggagct gcagaaactg ctaaagcaaa acttgaagga cctatggacg 26880

gccttcaacg agcgctccgt ggccgcgcac ctggcggaca tcattttccc cgaacgcctg 26940

cttaaaaccc tgcaacaggg tctgccagac ttcaccagtc aaagcatgtt gcagaacttt 27000

aggaacttta tcctagagcg ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc 27060

gactttgtgc ccattaagta ccgcgaatgc cctccgccgc tttggggcca ctgctacctt 27120

ctgcagctag ccaactacct tgcctaccac tctgacataa tggaagacgt gagcggtgac 27180

ggtctactgg agtgtcactg tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc 27240

aattcgcagc tgcttaacga aagtcaaatt atcggtacct ttgagctgca gggtccctcg 27300

cctgacgaaa agtccgcggc tccggggttg aaactcactc cggggctgtg gacgtcggct 27360

taccttcgca aatttgtacc tgaggactac cacgcccacg agattaggtt ctacgaagac 27420

caatcccgcc cgcctaatgc ggagcttacc gcctgcgtca ttacccaggg ccacattctt 27480

ggccaattgc aagccatcaa caaagcccgc caagagtttc tgctacgaaa gggacggggg 27540

gtttacttgg acccccagtc cggcgaggag ctcaacccaa tccccccgcc gccgcagccc 27600

tatcagcagc agccgcgggc ccttgcttcc caggatggca cccaaaaaga agctgcagct 27660

gccgccgcca cccacggacg aggaggaata ctgggacagt caggcagagg aggttttgga 27720

cgaggaggag gaggacatga tggaagactg ggagagccta gacgaggaag cttccgaggt 27780

cgaagaggtg tcagacgaaa caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca 27840

gaaatcggca accggttcca gcatggctac aacctccgct cctcaggcgc cgccggcact 27900

gcccgttcgc cgacccaacc gtagatggga caccactgga accaggggccg gtaagtccaa 27960

gcagccgccg ccgttagccc aagagcaaca acagcgccaa ggctaccgct catggcgcgg 28020

gcacaagaac gccatagttg cttgcttgca agactgtggg ggcaacatct ccttcgcccg 28080

ccgctttctt ctctaccatc acggcgtggc cttcccccgt aacatcctgc attactaccg 28140

tcatctctac agcccatact gcaccggcgg cagcggcagc aacagcagcg gccacacaga 28200

agcaaaggcg accggatagc aagactctga caaagcccaa gaaatccaca gcggcggcag 28260

cagcaggagg aggagcgctg cgtctggcgc ccaacgaacc cgtatcgacc cgcgagctta 28320

gaaacaggat ttttcccact ctgtatgcta tatttcaaca gagcaggggc caagaacaag 28380

agctgaaaat aaaaaacagg tctctgcgat ccctcacccg cagctgcctg tatcacaaaa 28440

gcgaagatca gcttcggcgc acgctggaag acgcggaggc tctcttcagt aaatactgcg 28500

cgctgactct taaggactag tttcgcgccc tttctcaaat ttaagcgcga aaactacgtc 28560

atctccagcg gccacacccg gcgccagcac ctgttgtcag cgccattatg agcaaggaaa 28620

ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28680

aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28740

acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28800

ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 28860

ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28920

gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28980

acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 29040

gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 29100

gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 29160

ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 29220

ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 29280

gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 29340

gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 29400

aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 29460

gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 29520

gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat cctctagtta 29580

atgtcaggtc gcctaagtcg attaactaga gtacccgggg atcttattcc ctttaactaa 29640

taaaaaaaaa taataaagca tcacttactt aaaatcagtt agcaaatttc tgtccagttt 29700

attcagcagc acctccttgc cctcctccca gctctggtat tgcagcttcc tcctggctgc 29760

aaactttctc cacaatctaa atggaatgtc agtttcctcc tgttcctgtc catccgcacc 29820

cactatcttc atgttgttgc agatgaagcg cgcaagaccg tctgaagata ccttcaaccc 29880

cgtgtatcca tatgacacgg aaaccggtcc tccaactgtg ccttttctta ctcctccctt 29940

tgtatccccc aatgggtttc aagagagtcc ccctggggta ctctctttgc gcctatccga 30000

acctctagtt acctccaatg gcatgcttgc gctcaaaatg ggcaacggcc tctctctgga 30060

cgaggccggc aaccttacct cccaaaatgt aaccactgtg agcccacctc tcaaaaaaac 30120

caagtcaaac ataaacctgg aaatatctgc acccctcaca gttacctcag aagccctaac 30180

tgtggctgcc gccgcacctc taatggtcgc gggcaacaca ctcaccatgc aatcacaggc 30240

cccgctaacc gtgcacgact ccaaacttag cattgccacc caaggacccc tcacagtgtc 30300

agaaggaaag ctagccctgc aaacatcagg ccccctcacc accaccgata gcagtaccct 30360

tactatcact gcctcacccc ctctaactac tgccactggt agcttgggca ttgacttgaa 30420

agagcccatt tatacacaaa atggaaaact aggactaaag tacggggctc ctttgcatgt 30480

aacagacgac ctaaacactt tgaccgtagc aactggtcca ggtgtgacta ttaataatac 30540

ttccttgcaa actaaagtta ctggagcctt gggttttgat tcacaaggca atatgcaact 30600

taatgtagca ggaggactaa ggattgattc tcaaaacaga cgccttatac ttgatgttag 30660

ttatccgttt gatgctcaaa accaactaaa tctaagacta ggacagggcc ctctttttat 30720

aaactcagcc cacaacttgg atattaacta caacaaaggc ctttacttgt ttacagcttc 30780

aaacaattcc aaaaagcttg aggttaacct aagcactgcc aaggggttga tgtttgacgc 30840

tacagccata gccattaatg caggagatgg gcttgaattt ggttcaccta atgcaccaaa 30900

cacaaatccc ctcaaaacaa aaattggcca tggcctagaa tttgattcaa acaaggctat 30960

ggttcctaaa ctaggaactg gccttagttt tgacagcaca ggtgccatta cagtaggaaa 31020

caaaaataat gataagctaa ctttgtggac cggaataaac cctccaccta actgtcaaat 31080

tgtggaaaac actaatacaa atgatggcaa acttacttta gtattagtaa aaaatggagg 31140

gcttgttaat ggctacgtgt ctctagttgg tgtatcagac actgtgaacc aaatgttcac 31200

acaaaagaca gcaaacatcc aattaagatt atattttgac tcttctggaa atctattaac 31260

tgaggaatca gacttaaaaa ttccacttaa aaataaatct tctacagcga ccagtgaaac 31320

tgtagccagc agcaaagcct ttatgccaag tactacagct tatcccttca acaccactac 31380

tagggatagt gaaaactaca ttcatggaat atgttactac atgactagtt atgatagaag 31440

tctatttccc ttgaacattt ctataatgct aaacagccgt atgatttctt ccaatgttgc 31500

ctatgccata caatttgaat ggaatctaaa tgcaagtgaa tctccagaaa gcaacatagc 31560

tacgctgacc acatccccct ttttcttttc ttacattaca gaagacgaca actaaagaat 31620

cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca gaaaatttca agtcattttt 31680

cattcagtag tatagcccca ccaccacata gcttatacag atcaccgtac cttaatcaaa 31740

ctcacagaac cctagtattc aacctgccac ctccctccca acacacagag tacacagtcc 31800

tttctccccg gctggcctta aaaagcatca tatcatgggt aacagacata ttcttaggtg 31860

ttatattcca cacggtttcc tgtcgagcca aacgctcatc agtgatatta ataaactccc 31920

cgggcagctc acttaagttc atgtcgctgt ccagctgctg agccacaggc tgctgtccaa 31980

cttgcggttg cttaacgggc ggcgaaggag aagtccacgc ctacatgggg gtagagtcat 32040

aatcgtgcat caggataggg cggtggtgct gcagcagcgc gcgaataaac tgctgccgcc 32100

gccgctccgt cctgcaggaa tacaacatgg cagtggtctc ctcagcgatg attcgcaccg 32160

cccgcagcat aaggcgcctt gtcctccggg cacagcagcg caccctgatc tcacttaaat 32220

cagcacagta actgcagcac agcaccacaa tattgttcaa aatcccacag tgcaaggcgc 32280

tgtatccaaa gctcatggcg gggaccacag aacccacgtg gccatcatac cacaagcgca 32340

ggtagattaa gtggcgaccc ctcataaaca cgctggacat aaacattacc tcttttggca 32400

tgttgtaatt caccacctcc cggtaccata taaacctctg attaaacatg gcgccatcca 32460

cccacatcct aaaccagctg gccaaaacct gcccgccggc tatacactgc agggaaccgg 32520

gactggaaca atgacagtgg agagcccagg actcgtaacc atggatcatc atgctcgtca 32580

tgatatcaat gttggcacaa cacaggcaca cgtgcataca cttcctcagg attacaagct 32640

cctcccgcgt tagaaccata tcccagggaa caacccattc ctgaatcagc gtaaatccca 32700

cactgcaggg aagacctcgc acgtaactca cgttgtgcat tgtcaaagtg ttacattcgg 32760

gcagcagcgg atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa ggaggtagac 32820

gatccctact gtacggagtg cgccgagaca accgagatcg tgttggtcgt agtgtcatgc 32880

caaatggaac gccggacgta gtcatatttc ctgaagcaaa accaggtgcg ggcgtgacaa 32940

acagatctgc gtctccggtc tcgccgctta gatcgctctg tgtagtagtt gtagtatatc 33000

cactctctca aagcatccag gcgccccctg gcttcgggtt ctatgtaaac tccttcatgc 33060

gccgctgccc tgataacatc caccaccgca gaataagcca cacccagcca acctacacat 33120

tcgttctgcg agtcacacac gggaggagcg ggaagagctg gaagaaccat gtttttttttt 33180

ttattccaaa agattatcca aaacctcaaa atgaagatct attaagtgaa cgcgctcccc 33240

tccggtggcg tggtcaaact ctacagccaa agaacagata atggcatttg taagatgttg 33300

cacaatggct tccaaaaggc aaacggccct cacgtccaag tggacgtaaa ggctaaaccc 33360

ttcaggtga atctcctcta taaacattcc agcaccttca accatgccca aataattctc 33420

atctcgccac cttctcaata tatctctaag caaatcccga atattaagtc cggccattgt 33480

aaaaatctgc tccagagcgc cctccacctt cagcctcaag cagcgaatca tgattgcaaa 33540

aattcaggtt cctcacagac ctgtataaga ttcaaaagcg gaacattaac aaaaataccg 33600

cgatcccgta ggtcccttcg cagggccagc tgaacataat cgtgcaggtc tgcacggacc 33660

agcgcggcca cttccccgcc aggaaccatg acaaaagaac ccacactgat tatgacacgc 33720

atactcggag ctatgctaac cagcgtagcc ccgatgtaag cttgttgcat gggcggcgat 33780

ataaaatgca aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa agaaagcaca 33840

tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaaccaccac agaaaaagac 33900

accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata aaataacaaa 33960

aaaacattta aacattagaa gcctgtctta caacaggaaa aacaaccctt ataagcataa 34020

gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga ttaaaaagca 34080

ccaccgacag ctcctcggtc atgtccggag tcataatgta agactcggta aacacatcag 34140

gttgattcac atcggtcagt gctaaaaagc gaccgaaata gcccggggga atacataccc 34200

gcaggcgtag agacaacatt acagccccca taggaggtat aacaaaatta ataggagaga 34260

aaaacacata aacacctgaa aaaccctcct gcctaggcaa aatagcaccc tcccgctcca 34320

gaacaacata cagcgcttcc acagcggcag ccataacagt cagccttacc agtaaaaaag 34380

aaaacctatt aaaaaaacac cactcgacac ggcaccagct caatcagtca cagtgtaaaa 34440

aagggccaag tgcagagcga gtatatatag gactaaaaaa tgacgtaacg gttaaagtcc 34500

acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca gaaacgaaag ccaaaaaacc 34560

cacaacttcc tcaaatcgtc acttccgttt tcccacgtta cgtcacttcc cattttaaga 34620

aaactacaat tcccaacaca tacaagttac tccgccctaa aacctacgtc acccgccccg 34680

ttcccacgcc ccgcgccacg tcacaaactc caccccctca ttatcatatt ggcttcaatc 34740

caaaataagg tatattattg atgatg 34766

<210> 30

<211> 35726

<212> DNA

<213> Artificial sequence

<220>

<223> Adk35F2-Spike/E4orf6(mPGK)-E4dl-711(E4re#29)

<400> 30

ttaattaaca tcatcaataa tataccttat tttggattga agccaatatg ataatgaggg 60

ggtggagttt gtgacgtggc gcggggcgtg ggaacggggc gggtgacgta gtagtgtggc 120

ggaagtgtga tgttgcaagt gtggcggaac acatgtaagc gacggatgtg gcaaaagtga 180

cgtttttggt gtgcgccggt gtacacagga agtgacaatt ttcgcgcggt tttaggcgga 240

tgttgtagta aatttgggcg taaccgagta agatttggcc attttcgcgg gaaaactgaa 300

taagaggaag tgaaatctga ataattttgt gttactcata gcgcgtaata atttctgtaa 360

tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa 420

cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 480

atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 540

tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc 600

cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 660

tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 720

cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt 780

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 840

aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag 900

gtctatataa gcagagctct ccctatcagt gatagagatc tccctatcag tgatagagat 960

cgtcgacgag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt 1020

gacctccata gaagacaccg ggaccgatcc agcctccgat ttgccaccat gtttgtgttc 1080

ctggtgctgc tgccactggt gtccagccag tgtgtgaacc tgaccaccag gacccaactt 1140

cctcctgcct acaccaactc cttcaccagg ggagtctact accctgacaa ggtgttcagg 1200

tcctctgtgc tgcacagcac ccaggacctg ttcctgccat tcttcagcaa tgtgacctgg 1260

ttccatgcca tccatgtgtc tggcaccaat ggcaccaaga ggtttgacaa ccctgtgctg 1320

ccattcaatg atggagtcta ctttgccagc acagagaaga gcaacatcat caggggctgg 1380

atttttggca ccaccctgga cagcaagacc cagtccctgc tgattgtgaa caatgccacc 1440

aatgtggtga ttaaggtgtg tgagttccag ttctgtaatg acccattcct gggagtctac 1500

taccacaaga acaacaagtc ctggatggag tctgagttca gggtctactc ctctgccaac 1560

aactgtacct ttgaatatgt gagccaacca ttcctgatgg acttggaggg caagcagggc 1620

aacttcaaga acctgaggga gtttgtgttc aagaacattg atggctactt caagatttac 1680

agcaaacaca caccaatcaa cctggtgagg gacctgccac agggcttctc tgccttggaa 1740

ccactggtgg acctgccaat tggcatcaac atcaccaggt tccagaccct gctggctctg 1800

cacaggtcct acctgacacc tggagactcc tcctctggct ggacagcagg agcagcagcc 1860

tactatgtgg gctacctcca accaaggacc ttcctgctga aatacaatga gaatggcacc 1920

atcacagatg ctgtggactg tgccctggac ccactgtctg agaccaagtg taccctgaaa 1980

tccttcacag tggagaaggg catctaccag accagcaact tcagggtcca accaacagag 2040

agcattgtga ggtttccaaa catcaccaac ctgtgtccat ttggagaggt gttcaatgcc 2100

accaggtttg cctctgtcta tgcctggaac aggaagagga ttagcaactg tgtggctgac 2160

tactctgtgc tctacaactc tgcctccttc agcaccttca agtgttatgg agtgagccca 2220

accaaactga atgacctgtg tttcaccaat gtctatgctg actcctttgt gattagggga 2280

gatgaggtga gacagattgc ccctggacaa acaggcaaga ttgctgacta caactacaaa 2340

ctgcctgatg acttcacagg ctgtgtgatt gcctggaaca gcaacaacct ggacagcaag 2400

gtgggaggca actacaacta cctctacaga ctgttcagga agagcaacct gaaaccattt 2460

gagagggaca tcagcacaga gatttaccag gctggcagca caccatgtaa tggagtggag 2520

ggcttcaact gttactttcc actccaatcc tatggcttcc aaccaaccaa tggagtgggc 2580

taccaaccat acagggtggt ggtgctgtcc tttgaactgc tccatgcccc tgccacagtg 2640

tgtggaccaa agaagagcac caacctggtg aagaacaagt gtgtgaactt caacttcaat 2700

ggactgacag gcacaggagt gctgacagag agcaacaaga agttcctgcc attccaacag 2760

tttggcaggg acattgctga caccacagat gctgtgaggg acccacagac cttggagatt 2820

ctggacatca caccatgttc ctttggagga gtgtctgtga ttacacctgg caccaacacc 2880

agcaaccagg tggctgtgct ctaccaggat gtgaactgta ctgaggtgcc tgtggctatc 2940

catgctgacc aacttacacc aacctggagg gtctacagca caggcagcaa tgtgttccag 3000

accagggctg gctgtctgat tggagcagag catgtgaaca actcctatga gtgtgacatc 3060

ccaattggag caggcatctg tgcctcctac cagacccaga ccggtggcgg tgggtcgagg 3120

tctgtggcaa gccagagcat cattgcctac acaatgagtc tgggagcaga gaactctgtg 3180

gcttacagca acaacagcat tgccatccca accaacttca ccatctctgt gaccacagag 3240

attctgcctg tgagtatgac caagacctct gtggactgta caatgtatat ctgtggagac 3300

agcacagagt gtagcaacct gctgctccaa tatggctcct tctgtaccca acttaacagg 3360

gctctgacag gcattgctgt ggaacaggac aagaacaccc aggaggtgtt tgcccaggtg 3420

aagcagattt acaagacacc tccaatcaag gactttggag gcttcaactt cagccagatt 3480

ctgcctgacc caagcaagcc aagcaagagg tccttcattg aggacctgct gttcaacaag 3540

gtgaccctgg ctgatgctgg cttcatcaag caatatggag actgtctggg agacattgct 3600

gccagggacc tgatttgtgc ccagaagttc aatggactga cagtgctgcc tccactgctg 3660

acagatgaga tgattgccca atacacctct gccctgctgg ctggcaccat cacctctggc 3720

tggacctttg gagcaggagc agccctccaa atcccatttg ctatgcagat ggcttacagg 3780

ttcaatggca ttggagtgac ccagaatgtg ctctatgaga accagaaact gattgccaac 3840

cagttcaact ctgccattgg caagattcag gactccctgt ccagcacagc ctctgccctg 3900

ggcaaactcc aagatgtggt gaaccagaat gcccaggctc tgaacaccct ggtgaagcaa 3960

ctttccagca actttggagc catctcctct gtgctgaatg acatcctgag cagactggac 4020

aaggtggagg ctgaggtcca gattgacaga ctgattacag gcagactcca atccctccaa 4080

acctatgtga cccaacaact tatcagggct gctgagatta gggcatctgc caacctggct 4140

gccaccaaga tgagtgagtg tgtgctggga caaagcaaga gggtggactt ctgtggcaag 4200

ggctaccacc tgatgagttt tccacagtct gcccctcatg gagtggtgtt cctgcatgtg 4260

acctatgtgc ctgcccagga gaagaacttc acccacagccc ctgccatctg ccatgatggc 4320

aaggctcact ttccaaggga gggagtgttt gtgagcaatg gcacccactg gtttgtgacc 4380

cagaggaact tctatgaacc acagattatc accacagaca acacctttgt gtctggcaac 4440

tgtgatgtgg tgattggcat tgtgaacaac acagtctatg acccactcca acctgaactg 4500

gactccttca aggaggaact ggacaaatac ttcaagaacc acaccagccc tgatgtggac 4560

ctggggagaca tctctggcat caatgcctct gtggtgaaca tccagaagga gattgacaga 4620

ctgaatgagg tggctaagaa cctgaatgag tccctgattg acctccaaga actgggcaaa 4680

tatgaacaat acatcaagtg gccatgaaaa ttgatcataa tcagccatac cacatttgta 4740

gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 4800

aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 4860

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 4920

aaactcatca atgtatctta acgcggatcg ggtaggggag gcgcttttcc caaggcagtc 4980

tggagcatgc gctttagcag ccccgctggg cacttggcgc tacacaagtg gcctctggcc 5040

tcgcacacat tccacatcca ccggtaggcg ccaaccggct ccgttctttg gtggcccctt 5100

cgcgccacct tctactcctc ccctagtcag gaagttcccc cccgccccgc agctcgcgtc 5160

gtgcaggacg tgacaaatgg aagtagcacg tctcactagt ctcgtgcaga tggacagcac 5220

cgctgagcaa tggaagcggg taggcctttg gggcagcggc caatagcagc tttgctcctt 5280

cgctttctgg gctcagaggc tgggaagggg tgggtccggg ggcgggctca ggggcgggct 5340

caggggcggg gcgggcgccc gaaggtcctc cggaggcccg gcattctgca cgcttcaaaa 5400

gcgcacgtct gccgcgctgt tctcctcttc ctcatctccg ggcctttcga aactacccca 5460

agctggccac catgactacg tccggcgttc catttggcat gacactacga ccaacacgat 5520

ctcggttgtc tcggcgcact ccgtacagta gggatcgtct acctcctttt gagacagaaa 5580

cccgcgctac catactggag gatcatccgc tgctgcccga atgtaacact ttgacaatgc 5640

acaacgtgag ttacgtgcga ggtcttccct gcagtgtggg atttacgctg attcaggaat 5700

gggttgttcc ctgggatatg gttctaacgc gggaggagct tgtaatcctg aggaagtgta 5760

tgcacgtgtg cctgtgttgt gccaacattg atatcatgac gagcatgatg atccatggtt 5820

acgagtcctg ggctctccac tgtcattgtt ccagtcccgg ttccctgcag tgtatagccg 5880

gcgggcaggt tttggccagc tggtttagga tggtggtgga tggcgccatg tttaatcaga 5940

ggtttatatg gtaccgggag gtggtgaatt acaacatgcc aaaagaggta atgtttatgt 6000

ccagcgtgtt tatgaggggt cgccacttaa tctacctgcg cttgtggtat gatggccacg 6060

tgggttctgt ggtccccgcc atgagctttg gatacagcgc cttgcactgt gggattttga 6120

acaatattgt ggtgctgtgc tgcagttact gtgctgattt aagtgagatc agggtgcgct 6180

gctgtgcccg gaggacaagg cgccttatgc tgcgggcggt gcgaatcatc gctgaggaga 6240

ccactgccat gttgtattcc tgcaggacgg agcggcggcg gcagcagttt attcgcgcgc 6300

tgctgcagca ccaccgccct atcctgatgc acgattatga ctctaccccc atgtagaagc 6360

ttggggatca attctctaga gctcgctgat cagcctcgac tgtgccttct agttgccagc 6420

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg 6480

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc 6540

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg 6600

ctggggatgc ggtgggctct atggcttctg aggaaattgg gcgtggctta agggtgggaa 6660

agaatatata aggtgggggt cttatgtagt tttgtatctg ttttgcagca gccgccgccg 6720

ccatgagcac caactcgttt gatggaagca ttgtgagctc atatttgaca acgcgcatgc 6780

ccccatgggc cggggtgcgt cagaatgtga tgggctccag cattgatggt cgccccgtcc 6840

tgcccgcaaa ctctactacc ttgacctacg agaccgtgtc tggaacgccg ttggagactg 6900

cagcctccgc cgccgcttca gccgctgcag ccaccgcccg cgggattgtg actgactttg 6960

ctttcctgag cccgcttgca agcagtgcag cttcccgttc atccgcccgc gatgacaagt 7020

tgacggctct tttggcacaa ttggattctt tgacccggga acttaatgtc gtttctcagc 7080

agctgttgga tctgcgccag caggtttctg ccctgaaggc ttcctcccct cccaatgcgg 7140

tttaaaacat aaataaaaaa ccagactctg tttggatttg gatcaagcaa gtgtcttgct 7200

gtctttattt aggggttttg cgcgcgcggt aggcccggga ccagcggtct cggtcgttga 7260

gggtcctgtg tattttttcc aggacgtggt aaaggtgact ctggatgttc agatacatgg 7320

gcataagccc gtctctgggg tggaggtagc accactgcag agcttcatgc tgcggggtgg 7380

tgttgtagat gatccagtcg tagcaggagc gctgggcgtg gtgcctaaaa atgtctttca 7440

gtagcaagct gattgccagg ggcaggccct tggtgtaagt gtttacaaag cggttaagct 7500

gggatgggtg catacgtggg gatatgagat gcatcttgga ctgtattttt aggttggcta 7560

tgttcccagc catatccctc cggggattca tgttgtgcag aaccaccagc acagtgtatc 7620

cggtgcactt gggaaatttg tcatgtagct tagaaggaaa tgcgtggaag aacttggaga 7680

cgcccttgtg acctccaaga ttttccatgc attcgtccat aatgatggca atgggcccac 7740

gggcggcggc ctgggcgaag atatttctgg gatcactaac gtcatagttg tgttccagga 7800

tgagatcgtc ataggccatt tttacaaagc gcgggcggag ggtgccagac tgcggtataa 7860

tggttccatc cggcccaggg gcgtagttac cctcacagat ttgcatttcc cacgctttga 7920

gttcagatgg ggggatcatg tctacctgcg gggcgatgaa gaaaacggtt tccggggtag 7980

ggggagatcag ctgggaagaa agcaggttcc tgagcagctg cgacttaccg cagccggtgg 8040

gcccgtaaat cacacctatt accgggtgca actggtagtt aagagagctg cagctgccgt 8100

catccctgag caggggggcc acttcgttaa gcatgtccct gactcgcatg ttttccctga 8160

ccaaatccgc cagaaggcgc tcgccgccca gcgatagcag ttcttgcaag gaagcaaagt 8220

ttttcaacgg tttgagaccg tccgccgtag gcatgctttt gagcgtttga ccaagcagtt 8280

ccaggcggtc ccacagctcg gtcacctgct ctacggcatc tcgatccagc atatctcctc 8340

gtttcgcggg ttggggcggc tttcgctgta cggcagtagt cggtgctcgt cgacgggc 8400

cagggtcatg tctttccacg ggcgcagggt cctcgtcagc gtagtctggg tcacggtgaa 8460

ggggtgcgct ccgggctgcg cgctggccag ggtgcgcttg aggctggtcc tgctggtgct 8520

gaagcgctgc cggtcttcgc cctgcgcgtc ggccaggtag catttgacca tggtgtcata 8580

gtccagcccc tccgcggcgt ggcccttggc gcgcagcttg cccttggagg aggcgccgca 8640

cgaggggcag tgcagacttt tgagggcgta gagcttgggc gcgagaaata ccgattccgg 8700

ggagtaggca tccgcgccgc aggccccgca gacggtctcg cattccacga gccaggtgag 8760

ctctggccgt tcggggtcaa aaaccaggtt tcccccatgc tttttgatgc gtttcttacc 8820

tctggtttcc atgagccggt gtccacgctc ggtgacgaaa aggctgtccg tgtccccgta 8880

tacagacttg agaggcctgt cctcgagcgg tgttccgcgg tcctcctcgt atagaaactc 8940

ggaccactct gagacaaagg ctcgcgtcca ggccagcacg aaggaggcta agtgggagg 9000

gtagcggtcg ttgtccacta gggggtccac tcgctccagg gtgtgaagac acatgtcgcc 9060

ctcttcggca tcaaggaagg tgattggttt gtaggtgtag gccacgtgac cgggtgttcc 9120

tgaagggggg ctataaaagg gggtgggggc gcgttcgtcc tcactctctt ccgcatcgct 9180

gtctgcgagg gccagctgtt ggggtgagta ctccctctga aaagcgggca tgacttctgc 9240

gctaagattg tcagtttcca aaaacgagga ggatttgata ttcacctggc ccgcggtgat 9300

gcctttgagg gtggccgcat ccatctggtc agaaaagaca atctttttgt tgtcaagctt 9360

ggtggcaaac gacccgtaga gggcgttgga cagcaacttg gcgatggagc gcagggtttg 9420

gtttttgtcg cgatcggcgc gctccttggc cgcgatgttt agctgcacgt attcgcgcgc 9480

aacgcaccgc cattcgggaa agacggtggt gcgctcgtcg ggcaccaggt gcacgcgcca 9540

accgcggttg tgcagggtga caaggtcaac gctggtggct acctctccgc gtaggcgctc 9600

gttggtccag cagaggcggc cgcccttgcg cgagcagaat ggcggtaggg ggtctagctg 9660

cgtctcgtcc ggggggtctg cgtccacggt aaagaccccg ggcagcaggc gcgcgtcgaa 9720

gtagtctatc ttgcatcctt gcaagtctag cgcctgctgc catgcgcggg cggcaagcgc 9780

gcgctcgtat gggttgagtg ggggacccca tggcatgggg tgggtgagcg cggaggcgta 9840

catgccgcaa atgtcgtaaa cgtagagggg ctctctgagt attccaagat atgtagggta 9900

gcatcttcca ccgcggatgc tggcgcgcac gtaatcgtat agttcgtgcg agggagcgag 9960

gaggtcggga ccgaggttgc tacgggcggg ctgctctgct cggaagacta tctgcctgaa 10020

gatggcatgt gagttggatg atatggttgg acgctggaag acgttgaagc tggcgtctgt 10080

gagacctacc gcgtcacgca cgaaggaggc gtaggagtcg cgcagcttgt tgaccagctc 10140

ggcggtgacc tgcacgtcta gggcgcagta gtccagggtt tccttgatga tgtcatactt 10200

atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc ggtctttcca 10260

gtactcttgg atcggaaacc cgtcggcctc cgaacggtaa gagcctagca tgtagaactg 10320

gttgacggcc tggtaggcgc agcatccctt ttctacgggt agcgcgtatg cctgcgcggc 10380

cttccggagc gaggtgtggg tgagcgcaaa ggtgtccctg accatgactt tgaggtactg 10440

gtatttgaag tcagtgtcgt cgcatccgcc ctgctcccag agcaaaaagt ccgtgcgctt 10500

tttggaacgc ggatttggca gggcgaaggt gacatcgttg aagagtatct ttcccgcgcg 10560

aggcataaag ttgcgtgtga tgcggaaggg tcccggcacc tcggaacggt tgttaattac 10620

ctgggcggcg agcacgatct cgtcaaagcc gttgatgttg tggcccacaa tgtaaagttc 10680

caagaagcgc gggatgccct tgatggaagg caatttttta agttcctcgt aggtgagctc 10740

ttcaggggag ctgagcccgt gctctgaaag ggcccagtct gcaagatgag ggttggaagc 10800

gacgaatgag ctccacaggt cacggggccat tagcatttgc aggtggtcgc gaaaggtcct 10860

aaactggcga cctatggcca ttttttctgg ggtgatgcag tagaaggtaa gcgggtcttg 10920

ttcccagcgg tcccatccaa ggttcgcggc taggtctcgc gcggcagtca ctagaggctc 10980

atctccgccg aacttcatga ccagcatgaa gggcacgagc tgcttcccaa aggcccccat 11040

ccaagtatag gtctctacat cgtaggtgac aaagagacgc tcggtgcgag gatgcgagcc 11100

gatcgggaag aactggatct cccgccacca attggaggag tggctattga tgtggtgaaa 11160

gtagaagtcc ctgcgacggg ccgaacactc gtgctggctt ttgtaaaaac gtgcgcagta 11220

ctggcagcgg tgcacgggct gtacatcctg cacgaggttg acctgacgac cgcgcacaag 11280

gaagcagagt gggaatttga gcccctcgcc tggcgggttt ggctggtggt cttctacttc 11340

ggctgcttgt ccttgaccgt ctggctgctc gaggggagtt acggtggatc ggaccaccac 11400

gccgcgcgag cccaaagtcc agatgtccgc gcgcggcggt cggagcttga tgacaacatc 11460

gcgcagatgg gagctgtcca tggtctggag ctcccgcggc gtcaggtcag gcgggagctc 11520

ctgcaggttt acctcgcata gacgggtcag ggcgcgggct agatccaggt gatacctaat 11580

ttccaggggc tggttggtgg cggcgtcgat ggcttgcaag aggccgcatc cccgcggcgc 11640

gactacggta ccgcgcggcg ggcggtgggc cgcggggggtg tccttggatg atgcatctaa 11700

aagcggtgac gcgggcgagc ccccggaggt aggggggggct ccggacccgc cggggagagg 11760

ggcaggggca cgtcggcgcc gcgcgcgggc aggagctggt gctgcgcgcg taggttgctg 11820

gcgaacgcga cgacgcggcg gttgatctcc tgaatctggc gcctctgcgt gaagacgacg 11880

ggcccggtga gcttgaacct gaaagagagt tcgacagaat caatttcggt gtcgttgacg 11940

gcggcctggc gcaaaatctc ctgcacgtct cctgagttgt cttgataggc gatctcggcc 12000

atgaactgct cgatctcttc ctcctggaga tctccgcgtc cggctcgctc cacggtggcg 12060

gcgaggtcgt tggaaatgcg ggccatgagc tgcgagaagg cgttgaggcc tccctcgttc 12120

cagacgcggc tgtagaccac gcccccttcg gcatcgcggg cgcgcatgac cacctgcgcg 12180

agattgagct ccacgtgccg ggcgaagacg gcgtagtttc gcaggcgctg aaagaggtag 12240

ttgaggtgg tggcggtgtg ttctgccacg aagaagtaca taacccagcg tcgcaacgtg 12300

gattcgttga tatcccccaa ggcctcaagg cgctccatgg cctcgtagaa gtccacggcg 12360

aagttgaaaa actgggagtt gcgcgccgac acggttaact cctcctccag aagacggatg 12420

agctcggcga cagtgtcgcg cacctcgcgc tcaaaggcta caggggcctc ttcttcttct 12480

tcaatctcct cttccataag ggcctcccct tcttcttctt ctggcggcgg tgggggagg 12540

gggacacggc ggcgacgacg gcgcaccggg aggcggtcga caaagcgctc gatcatctcc 12600

ccgcggcgac ggcgcatggt ctcggtgacg gcgcggccgt tctcgcgggg gcgcagttgg 12660

aagacgccgc ccgtcatgtc ccggttatgg gttggcgggg ggctgccatg cggcagggat 12720

acggcgctaa cgatgcatct caacaattgt tgtgtaggta ctccgccgcc gagggacctg 12780

agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag 12840

tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg 12900

gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac 12960

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag 13020

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc 13080

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg 13140

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc 13200

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc 13260

gtgaggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg 13320

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc 13380

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc 13440

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt 13500

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg 13560

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg 13620

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc 13680

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct 13740

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc 13800

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg 13860

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc 13920

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc 13980

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc 14040

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg 14100

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca 14160

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca 14220

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc 14280

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct 14340

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggcaccc 14400

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg 14460

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga 14520

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc 14580

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata 14640

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac 14700

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc 14760

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca 14820

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg 14880

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag 14940

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc 15000

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt 15060

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa 15120

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct 15180

gatgcacagc ctgcaaaggg ccctggctgg cacggggcagc ggcgatagag aggccgagtc 15240

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc 15300

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga 15360

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt 15420

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag 15480

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg 15540

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt 15600

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta 15660

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg 15720

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg 15780

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg 15840

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga 15900

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa 15960

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag 16020

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc 16080

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg 16140

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg 16200

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag 16260

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta 16320

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag 16380

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg 16440

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc 16500

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac 16560

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac 16620

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctggggacga catagacgac 16680

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag 16740

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg 16800

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact 16860

cgcaccaccc gcccgcgcct gctgggcgag gagggagtacc taaacaactc gctgctgcag 16920

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg 16980

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc 17040

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac 17100

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt 17160

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc 17220

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg 17280

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg 17340

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt 17400

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg 17460

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc 17520

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg 17580

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa 17640

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg 17700

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt 17760

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga 17820

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg 17880

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc 17940

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag 18000

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc 18060

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg 18120

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg 18180

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag 18240

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg 18300

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg 18360

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg 18420

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca 18480

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc 18540

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga 18600

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg 18660

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac 18720

tcatccgcca gtttacctct ctgaccacg tgttcaatcg ctttcccgag aaccagattt 18780

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag 18840

atcacgggac gctaccgctg cgcaacagca tcggagggagt ccagcgagtg accattactg 18900

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg 18960

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca 19020

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc 19080

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc 19140

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact 19200

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg 19260

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc 19320

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca 19380

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc 19440

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc 19500

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg 19560

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt 19620

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag 19680

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt 19740

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg 19800

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc 19860

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct 19920

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc 19980

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt 20040

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc 20100

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg 20160

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa 20220

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc 20280

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg 20340

ccaccgccac agaggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg 20400

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc 20460

cgtggatgtt tcgcgtttca gccccccggc gcccgcgccg ttcgaggaag tacggcgccg 20520

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc 20580

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa 20640

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg 20700

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt 20760

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg 20820

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg 20880

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg 20940

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg 21000

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc 21060

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa 21120

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg 21180

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc 21240

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc 21300

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat 21360

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag 21420

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca 21480

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg 21540

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc 21600

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac 21660

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt 21720

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg 21780

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa 21840

tccctgaagc gccgacgatg cttctgatag ctaacgtgtc gtatgtgtgt catgtatgcg 21900

tccatgtcgc cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac 21960

cccttcgatg atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta 22020

cctgagcccc gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa 22080

caagtttaga aaccccacgg tggcgcctac gcacgacgtg accaccagacc ggtcccagcg 22140

tttgacgctg cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg 22200

gttcacccta gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat 22260

ccgcggcgtg ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc 22320

cctggctccc aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga 22380

aataaaccta gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca 22440

gcaaaaaact cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg 22500

tattcaaata ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga 22560

acctcaaata ggagaatctc agtggtacga aacagaaatt aatcatgcag ctggggagagt 22620

cctaaaaaag actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga 22680

aaatggaggg caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga 22740

aatgcaattt ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa 22800

agtggtattg tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat 22860

gcccactatt aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag 22920

gcctaattac attgctttta gggacaattt tattggtcta atgtattaca acagcacggg 22980

taatatgggt gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga 23040

cagaaacaca gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta 23100

cttttctatg tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa 23160

tcatggaact gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac 23220

agagactctt accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc 23280

tacagaattt tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa 23340

tctaaatgcc aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga 23400

caagctaaag tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta 23460

catgaacaag cgagtggtgg ctcccggggct agtggactgc tacattaacc ttggagcacg 23520

ctggtccctt gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct 23580

gcgctaccgc tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc 23640

tcagaagttc tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg 23700

gaacttcagg aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt 23760

tgacggagcc agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc 23820

ccacaacacc gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt 23880

taacgactat ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt 23940

gcccatatcc atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct 24000

taagactaag gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg 24060

ctctataccc tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat 24120

tacctttgac tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt 24180

tgaaattaag cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa 24240

agactggttc ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat 24300

cccagagagc tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg 24360

tcaggtggtg gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca 24420

caacaactct ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc 24480

tgctaacttc ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa 24540

gtttctttgc gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg 24600

cgcactcaca gacctggggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat 24660

gacttttgag gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt 24720

tgacgtggtc cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac 24780

gcccttctcg gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc 24840

gccatgggct ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca 24900

tattttttgg gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc 24960

tgcgccatag tcaatacggc cggtcgcgag actggggggcg tacactggat ggcctttgcc 25020

tggaacccgc actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga 25080

ctcaagcagg tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct 25140

tcccccgacc gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg 25200

gccgcctgtg gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact 25260

cccatggatc acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac 25320

agtccccagg tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag 25380

cgccactcgc cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt 25440

cacttgaaaa acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt 25500

tatttgtaca ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa 25560

tcaaaggggt tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg 25620

tgtttagtgc tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca 25680

ctccacaggc tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag 25740

tcgcagttgg ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg 25800

aacactatca gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc 25860

gcgtccaggt cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc 25920

aaaaagggcg cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga 25980

ccgtgcccgg tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa 26040

gccacctgag cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga 26100

ttggccggac aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc 26160

acatttcggc cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg 26220

cgctgcccgt tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg 26280

cttccgtgta gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg 26340

cagcccgtgg gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc 26400

aggaatcgcc ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg 26460

cggtgctcct cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc 26520

agtagtttga agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc 26580

gcagcctcca tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc 26640

gtaatttcac tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc 26700

gccactgggt cgtcttcatt cagccgccgc actngtgcgct tacctccttt gccatgcttg 26760

attagcaccg gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc 26820

tcgctgtcca cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc 26880

tttttcttct tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt 26940

gtgcgcggca ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc 27000

ctcatccgct tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg 27060

tcctccatgg ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc 27120

tgctcctctt cccgactggc catttccttc tcctataggc agaaaaagat catggagtca 27180

gtcgagaaga aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat 27240

gccgccaacg cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg 27300

attatcgagc aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca 27360

gaggataaaa agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg 27420

gacgaaaggc atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag 27480

cgccagtgcg ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata 27540

gcggatgtca gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc 27600

caagaaaacg gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg 27660

ccagaggtgc ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc 27720

cgtgccaacc gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct 27780

gatatcgcct cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag 27840

cgcgcggcaa acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg 27900

gtggaactcg agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc 27960

cactttgcct acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag 28020

ctgatcgtgc gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag 28080

gagggcctac ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct 28140

gccgacttgg aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt 28200

gagtgcatgc agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg 28260

cactacacct ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc 28320

tgcaacctgg tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt 28380

cattccacgc tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt 28440

ctatgctaca cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac 28500

ctcaaggagc tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac 28560

gagcgctccg tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc 28620

ctgcaacagg gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt 28680

atcctagagc gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg 28740

cccattaagt accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta 28800

gccaactacc ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg 28860

gagtgtcact gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag 28920

ctgcttaacg aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa 28980

aagtccgcgg ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc 29040

aaatttgtac ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc 29100

ccgcctaatg cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg 29160

caagccatca acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg 29220

gacccccagt ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag 29280

cagccgcggg cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc 29340

acccacggac gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga 29400

ggaggacatg atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt 29460

gtcagacgaa acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc 29520

aaccggttcc agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg 29580

ccgacccaac cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc 29640

gccgttagcc caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa 29700

cgccatagtt gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct 29760

tctctaccat cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta 29820

cagcccatac tgcaccggcg gcagcggcag caacagcagc ggccacacag aagcaaaggc 29880

gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag 29940

gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga 30000

tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa 30060

taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc 30120

agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc 30180

ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc 30240

ggccacaccc ggcgccagca cctgttgtca gcgccattat gagcaaggaa attcccacgc 30300

cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact 30360

caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatac 30420

gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca cctcgtaata 30480

accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca 30540

ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc 30600

ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa 30660

tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc 30720

cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa 30780

tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat 30840

ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact 30900

atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact 30960

gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc 31020

acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata 31080

tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga 31140

ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca 31200

ctgtgatttg caactgtcct aaccctggat tacatcaaga tcctctagtt aatgtcaggt 31260

cgcctaagtc gattaactag agtacccggg gatcttattc cctttaacta ataaaaaaaa 31320

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag 31380

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct 31440

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt 31500

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc 31560

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc 31620

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt 31680

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg 31740

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa 31800

cataaacctg gaaatatctg cacccctcac agttacctca gaagcctaa ctgtggctgc 31860

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac 31920

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa 31980

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac 32040

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat 32100

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga 32160

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca 32220

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc 32280

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt 32340

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc 32400

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc 32460

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat 32520

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc 32580

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa 32640

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa 32700

tgataagcta actttgtgga ccggaataaa ccctccacct aactgtcaaa ttgtggaaaa 32760

cactaataca aatgatggca aacttacttt agtattagta aaaaatggag ggcttgttaa 32820

tggctacgtg tctctagttg gtgtatcaga cactgtgaac caaatgttca cacaaaagac 32880

agcaaacatc caattaagat tatattttga ctcttctgga aatctattaa ctgaggaatc 32940

agacttaaaa attccactta aaaataaatc ttctacagcg accagtgaaa ctgtagccag 33000

cagcaaagcc tttatgccaa gtactacagc ttatcccttc aacaccacta ctagggatag 33060

tgaaaactac attcatggaa tatgttacta catgactagt tatgatagaa gtctatttcc 33120

cttgaacatt tctataatgc taaacagccg tatgatttct tccaatgttg cctatgccat 33180

acaatttgaa tggaatctaa atgcaagtga atctccagaa agcaacatag ctacgctgac 33240

cacatccccc tttttctttt cttacattac agaagacgac aactaaagaa tcgtttgtgt 33300

tatgtttcaa cgtgtttatt tttcaattgc agaaaatttc aagtcatttt tcattcagta 33360

gtatagcccc accaccacat agcttataca gatcaccgta ccttaatcaa actcacagaa 33420

ccctagtatt caacctgcca cctccctccc aacacacaga gtacacagtc ctttctcccc 33480

ggctggcctt aaaaagcatc atatcatggg taacagacat attcttaggt gttatattcc 33540

acacggtttc ctgtcgagcc aaacgctcat cagtgatatt aataaactcc ccgggcagct 33600

cacttaagtt catgtcgctg tccagctgct gagccacagg ctgctgtcca acttgcggtt 33660

gcttaacggg cggcgaagga gaagtccacg cgttgtgcat tgtcaaagtg ttacattcgg 33720

gcagcagcgg atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa ggaggtagac 33780

gatccctact gtacggagtg cgccgagaca accgagatcg tgttggtcgt agtgtcatgc 33840

caaatggaac gccggacgta gtcatatttc ctgaagcaaa accaggtgcg ggcgtgacaa 33900

acagatctgc gtctccggtc tcgccgctta gatcgctctg tgtagtagtt gtagtatatc 33960

cactctctca aagcatccag gcgccccctg gcttcgggtt ctatgtaaac tccttcatgc 34020

gccgctgccc tgataacatc caccaccgca gaataagcca cacccagcca acctacacat 34080

tcgttctgcg agtcacacac gggaggagcg ggaagagctg gaagaaccat gtttttttttt 34140

ttattccaaa agattatcca aaacctcaaa atgaagatct attaagtgaa cgcgctcccc 34200

tccggtggcg tggtcaaact ctacagccaa agaacagata atggcatttg taagatgttg 34260

cacaatggct tccaaaaggc aaacggccct cacgtccaag tggacgtaaa ggctaaaccc 34320

ttcaggtga atctcctcta taaacattcc agcaccttca accatgccca aataattctc 34380

atctcgccac cttctcaata tatctctaag caaatcccga atattaagtc cggccattgt 34440

aaaaatctgc tccagagcgc cctccacctt cagcctcaag cagcgaatca tgattgcaaa 34500

aattcaggtt cctcacagac ctgtataaga ttcaaaagcg gaacattaac aaaaataccg 34560

cgatcccgta ggtcccttcg cagggccagc tgaacataat cgtgcaggtc tgcacggacc 34620

agcgcggcca cttccccgcc aggaaccatg acaaaagaac ccacactgat tatgacacgc 34680

atactcggag ctatgctaac cagcgtagcc ccgatgtaag cttgttgcat gggcggcgat 34740

ataaaatgca aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa agaaagcaca 34800

tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaaccaccac agaaaaagac 34860

accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata aaataacaaa 34920

aaaacattta aacattagaa gcctgtctta caacaggaaa aacaaccctt ataagcataa 34980

gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga ttaaaaagca 35040

ccaccgacag ctcctcggtc atgtccggag tcataatgta agactcggta aacacatcag 35100

gttgattcac atcggtcagt gctaaaaagc gaccgaaata gcccggggga atacataccc 35160

gcaggcgtag agacaacatt acagccccca taggaggtat aacaaaatta ataggagaga 35220

aaaacacata aacacctgaa aaaccctcct gcctaggcaa aatagcaccc tcccgctcca 35280

gaacaacata cagcgcttcc acagcggcag ccataacagt cagccttacc agtaaaaaag 35340

aaaacctatt aaaaaaacac cactcgacac ggcaccagct caatcagtca cagtgtaaaa 35400

aagggccaag tgcagagcga gtatatatag gactaaaaaa tgacgtaacg gttaaagtcc 35460

acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca gaaacgaaag ccaaaaaacc 35520

cacaacttcc tcaaatcgtc acttccgttt tcccacgtta cgtcacttcc cattttaaga 35580

aaactacaat tcccaacaca tacaagttac tccgccctaa aacctacgtc acccgccccg 35640

ttcccacgcc ccgcgccacg tcacaaactc caccccctca ttatcatatt ggcttcaatc 35700

caaaataagg tatattattg atgatg 35726

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Claims (15)

1. Recombinant spike protein, in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced, where the recombinant spike protein is used to obtain a vaccine for the prevention or treatment of coronavirus infection, wherein the antigen, the spike protein linked by a linker sequence, has increased stability and an increased level of expression of the antigen, and where the linker consists of GGGGS. 2. The recombinant spike protein according to claim 1, wherein the coronavirus is SARS-CoV, MERS-CoV or SARS-CoV-2. 3. The recombinant spike protein according to claim 2, wherein the coronavirus is SARS-CoV-2. 4. A polynucleotide encoding a recombinant spike protein, in which the cleavage site between the S1 and S2 genes of the coronavirus spike protein is removed and a linker sequence is introduced, where the antigen, the spike protein linked by the linker sequence, has increased stability and an increased level of antigen expression, and where the linker consists from GGGGS. 5. The polynucleotide according to claim 4, wherein the coronavirus is SARS-CoV, MERS-CoV or SARS-CoV-2. 6. An adenoviral vector containing a polynucleotide according to claim 4, where the adenoviral vector is used to produce a vaccine for the prevention or treatment of coronavirus infection. 7. The vector according to claim 6, where the coronavirus is SARS-CoV, MERS-CoV or SARS-CoV-2. 8. The vector according to claim 7, where the coronavirus is SARS-CoV-2. 9. The vector according to claim 6, where the adenovirus is Ad2, Ad4, Ad5, Ad11, Ad26, Ad35, ChAd68, FAd9 or PAd3. 10. The vector according to claim 9, where the adenovirus has a high level of antigen expression. 11. A vaccine for the prevention or treatment of coronavirus infection, containing the vector according to claim 6. 12. A vaccine for the prevention or treatment of coronavirus infection according to claim 11, where the coronavirus infection is SARS, MERS or COVID-19. 13. A method for preventing or treating coronavirus infection, including the step of introducing the vector according to claim 6.