KR20230058943A - Injection preparing device - Google Patents

Abstract

The disclosed invention relates to an injection preparation device, comprising: a vial fixing unit for fixing a vial in which a medicine is sealed and having a rubber stopper; and a spike fixing unit for fixing a spike that penetrates the rubber stopper of the vial to form a flow path. ; And, a spike up and down driving unit for moving the spike fixing unit in an up and down direction with respect to the vial fixing unit; And, a control panel for controlling the operation of the spike up and down driving unit; And, a pair of pistons provided therein are relatively fixed. and a cylinder pump equipped with a cylinder cartridge for introducing and discharging external fluid through a change in cylinder volume caused by a rotational motion, and independently driving a pair of pistons provided inside the cylinder cartridge. and a first tube connected to the outlet pipe of the cylinder cartridge, a 3-way valve selectively connecting one of the two inlet passages to the outlet passage, and an outlet passage of the 3-way valve to the inflow passage of the cylinder cartridge. A tube and valve assembly including a second tube connected to the pipe and a third tube connected to the first inflow passage of the 3-way valve, and connecting the second inflow passage of the 3-way valve to the spike.

Description

Injection preparation device {INJECTION PREPARING DEVICE}

The present invention relates to an injection preparation device, and more specifically, to a semi-automatic system that minimizes the amount of work that must be performed by an operator while configuring a closed system capable of minimizing contamination from the external environment, thereby allowing the operator to prepare highly toxic drugs The present invention relates to an injection preparation device capable of safely and accurately preparing and administering an injection by reducing the risk of exposure to the drug and at the same time reducing the number of errors caused by manual preparation.

In the medical field, which is responsible for the health and life of patients, blood transfusion for diseases, accidents, or excessive bleeding during surgery, or for the treatment of diseases caused by infections or weakened immunity, or when the body lacks water, electrolytes, or nutrients. As one of supplemental therapy, deficiency correction, and therapeutic therapy, it is generally made to inject blood, Ringer's solution, amino acid solution, glucose solution or various medicines into the patient's body.

A syringe pump or an infusion pump is used to inject injections such as blood and medicines into the patient at an accurate amount and speed according to a doctor's prescription. Syringe pump is a method of injecting by pushing the plunger of a syringe and applying pressure to the injection solution contained therein, and infusion pump is a method of injecting injection by squeezing the infusion tube of a drug solution container suspended at a height at which gravity acts appropriately for the patient. am. That is, the syringe pump and infusion pump are used separately according to the shape and type of the container in which the injection is sterilized and sealed, and the operation of pushing the plunger in the syringe pump and the operation of repeatedly pressing the infusion tube in the infusion pump are controlled by the motor As the injection is done accurately, the injection dose, rate, time, etc. proceed as prescribed.

On the other hand, injections often contain toxic drugs such as anticancer agents or contrast agents. Anticancer drugs, etc., must be handled by a professional pharmacist in a sterile dispensary. Professional pharmacists wash their hands thoroughly before entering the sterile dispensary, and then carefully wear personal protective equipment such as antibacterial clothing, antibacterial shoes, masks, hair caps, protective gloves, and safety glasses. Should be. In addition, even in the aseptic dispensary, the surrounding environment, such as the workbench, must be disinfected, and the prescriptions of the drugs handled must be accurately checked, and syringes, needles, and ampoules must be disinfected and discarded in a designated manner after use. In addition, the injection prepared in the aseptic dispensary must be maintained in a sterile state, and the problem of contamination must be minimized by releasing the seal immediately before administration to the patient.

As such, the procedure for handling toxic drugs such as anticancer drugs is very complex and strict, and even highly trained professional pharmacists always face difficulties and risks when directly handling toxic substances. In addition, complicated procedures must be repeated to mix several toxic drugs in one pack, and in this case, the possibility of error or mistake in dosage increases. In particular, it is not easy for a professional pharmacist surrounded by various personal protective equipment to maintain concentration for a long time, so it becomes an excessive burden to leave the responsibility for preparing toxic medicines only to professional pharmacists.

Conventionally, as a solution to this problem, an automated dispensing robot that mixes cytotoxic intravenous injections has been introduced. In the dispensing automation robot, an articulated robot arm is installed in an internal space where an aseptic environment is maintained, classified by barcode scan based on prescription data, and the articulated robot arm dispenses specified medicines to extract and dispense medicines with a syringe. It is a method that automatically proceeds a series of processes of injecting the drug into the container. That is, it is a method in which an articulated robot arm replaces the role of a conventional professional pharmacist as it is.

However, since the price of the device itself is too high compared to the operation rate, only a few units are sold to large hospitals with capital as the main customers, so it is not universally distributed in the front-line medical field where hundreds of thousands of cases of anticancer drugs are prepared annually. The limits were clear.

Republic of Korea Patent Registration No. 10-0948632 (registered on March 12, 2010)

The present invention is a preparation that combines various medicinal materials, especially toxic anticancer agents, parenteral nutrients that are fatal to contamination and infection, and the like, so that the preparation of injections, which must be carefully managed under strictly limited conditions, is safe and safe without using expensive equipment. Its purpose is to provide an injection preparation device that can be performed hygienically and conveniently.

The present invention relates to an injection preparation device, comprising: a vial fixing unit for fixing a vial in which medicine is sealed and having a rubber stopper; and a spike fixing unit for fixing a spike forming a flow path through the rubber stopper of the vial; And, a spike up and down drive unit for moving the spike fixing unit in an up and down direction relative to the vial fixing unit; and a control panel for controlling the operation of the spike up and down drive unit; and a pair of pistons provided therein are relatively fixed and A cylinder pump equipped with a cylinder cartridge that introduces and discharges external fluid through a change in cylinder volume caused by a rotating operation, and independently drives a pair of pistons provided inside the cylinder cartridge; and a first tube connected to the outlet pipe of the cylinder cartridge, a 3-way valve selectively connecting one of the two inlet passages to the outlet passage, and an outlet passage of the 3-way valve to the inflow passage of the cylinder cartridge. A tube and valve assembly including a second tube connected to the pipe and a third tube connected to the first inflow passage of the 3-way valve, and connecting the second inflow passage of the 3-way valve to the spike.

Here, the spike is maintained in a fixed state by penetrating the rubber stopper of the vial by the downward movement of the spike fixing unit.

According to one embodiment of the present invention, the vial fixing part, the spike fixing part, and the spike up and down driving part are fixed to one coupling plate, the coupling plate can be rotated in an inverted posture by the rotation driving unit, and the control panel Controls the operation of the rotary drive unit.

Then, the fluid pack is connected to the first tube and the third tube.

In one embodiment of the present invention, the spike body includes a first flow path through which one end communicates with an air vent hole, and a second flow path separated from the first flow path and capable of entering and exiting the drug; A first needle coupled to the other end of the first channel and protruding out of the spike body; coupled to one end of the second channel and protruding out of the spike body in the same direction as the first needle a second needle; and a female swivel valve coupled to the spike body so as to communicate with the other end of the second flow path and having a valve means opened only when the second inflow path of the 3-way valve is inserted.

Here, the length of the first needle may be longer than the length of the second needle, and in particular, the length of the second needle may correspond to the thickness of the rubber stopper of the vial.

On the other hand, the cylinder cartridge has an upper rotating body and a lower rotating body that rotate freely with each other, an annular cylinder space is formed between the upper rotating body and the lower rotating body, and a first piston of the pair of pistons The second piston may be coupled to the upper rotating body to rotate along the cylinder space, and the second piston may be coupled to the lower rotating body to rotate along the cylinder space.

The cylinder pump includes a cylinder driving unit independently driving a pair of pistons provided in the cylinder cartridge and a control unit controlling the cylinder driving unit, wherein the control unit determines the amount of liquid introduced and discharged through the cylinder cartridge. Control the speed to a preset value.

According to one embodiment of the present invention, in a state in which the 3-way valve is connected to the first tube and the second tube and the fluid pack connected to the third tube forms a circulation circuit, the control unit pre-transmits the fluid in the fluid pack. The air in the tube and valve assembly can be discharged by inflow and outflow through the cylinder cartridge at the set amount and speed.

In addition, in a state in which the 3-way valve forms a closed circuit in which the vial into which the spike is inserted, the second tube, and the first tube are connected, the control unit dispenses the medicine in the vial at a predetermined amount and speed through the cylinder cartridge. It can be introduced into the sap pack by inflow and outflow.

In addition, introducing the medicine in the vial into the sap pack may be performed in a state where the vial is inverted.

The injection preparation device of the present invention having the above configuration can automatically perform the conventional injector operation as the cylinder pump performs two operations of suction and discharge, and the intervention of workers is reduced accordingly, thereby reducing toxicity. The risk of handling a chemical solution with a chemical solution is greatly reduced, and the worry of mistakes in preparation is also eliminated because accurate weighing is performed automatically.

In addition, in the prior art, in the process of preparing injections, there is a moment when they are inevitably exposed to the external environment during the use of syringes and needles, so there is a risk of contamination or infection. Because the process is performed, a separate clean bench is not required. In addition, the risk of handling toxic medicines is significantly reduced as much as the high-risk work of inserting and withdrawing a needle directly by a medical person disappears as in the prior art.

In addition, since the present invention can prepare and inject injections without limiting the capacity, the work of sticking and withdrawing the needle several times using a syringe with limited capacity as in the prior art is eliminated, thereby reducing the risk of contamination and infection. significantly prevented.

In addition, the present invention solves all problems caused by negative pressure when extracting a drug from a vial and positive pressure when introducing a drug solution into a vial by using a needle-type spike having a pressure offset function.

In addition, the needle-type spike with a pressure offset function shortens the length of the second needle for extracting the drug to correspond to the thickness of the rubber stopper sealing the vial, so that the drug contained in the vial can be extracted to the maximum without any residual amount. As a result, waste medicines are minimized, environmental pollution is suppressed, and economic feasibility such as waste drug treatment costs and waste drug savings is improved.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the detailed description below.

1 is a view showing the overall configuration of an injection preparation device according to the present invention.
Figure 2 is a front view of the injection preparation device according to the present invention.
Figure 3 is a view showing the overall configuration of the cylinder pump.
Figure 4 is an exploded perspective view of a cylinder cartridge mounted on the cylinder pump of Figure 2;
5 is a view showing a state in which the cylinder cartridge is mounted on the cylinder pump of FIG. 2;
6 is a view of a cylinder driving unit provided in the cylinder pump of FIG. 2;
7 is an exploded perspective view of the cylinder driving unit of FIG. 5;
8 is a view showing a suction and discharge process performed in a cylinder cartridge;
9 is a view showing an example in which a vial takes an inverted posture in the injection preparation device according to the present invention.
10 is a view showing a spike having a pressure offset function applied to the present invention.
11 is a view showing a pressure offset effect when extracting a drug inside a vial using the spike of FIG. 10;

Since the present invention can apply various transformations and have various embodiments, specific embodiments will be exemplified and described in detail in the detailed description. However, it should be understood that this is not intended to limit the present invention to specific embodiments, and includes all transformations, equivalents, and substitutes included in the spirit and scope of the present invention.

Terms used in the present invention are only used to describe specific embodiments, and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly dictates otherwise. In the present invention, terms such as 'include' or 'having' are intended to designate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, but one or more other features It should be understood that the presence or addition of numbers, steps, operations, components, parts, or combinations thereof is not precluded.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. At this time, it should be noted that in the accompanying drawings, the same components are indicated by the same reference numerals as much as possible. In addition, detailed descriptions of well-known functions and configurations that may obscure the gist of the present invention will be omitted. For the same reason, in the accompanying drawings, some components are exaggerated, omitted, or schematically illustrated.

1 is a view showing the overall configuration of an injection preparation device 10 according to the present invention, and FIG. 2 is a front view of the injection preparation device 10 according to the present invention. The present invention will be described in detail with reference to the accompanying drawings.

The present invention relates to an injection preparation device (10), which is a preparation combining various medicinal materials, particularly in cases where strict management is required due to the inclusion of toxic anticancer agents or contrast media, so that injection preparations can be prepared more safely and accurately will be. The injection preparation device 10 of the present invention is largely divided into a vial fixing part 100, a spike fixing part 200, a spike up and down driving part 300, a control panel 800, a cylinder pump 500, and a tube and valve assembly. (700).

The vial fixing unit 100 is configured to fix the vial 900 in which the medicine is sealed and having a rubber stopper 910. The vial 900 mounted on the vial fixing unit 100 is stably mounted so that it does not leave its place even if the posture of the vial fixing unit 100 is changed, for example, reversed as described below. For example, as shown in FIG. 1, the vial 900 can be detachably and stably mounted by inserting the body of the vial 900 into a circular groove and locking the concave neck portion with a hinged clamp. Of course, in addition to this, various structures such as pressing and fixing the body of the vial 900 with a pneumatic tube may be applied, and the configuration of the vial fixing unit 100 is not limited to the illustrated embodiment.

The spike fixing part 200 is configured to fix the spike 1000 forming a flow path by penetrating the rubber stopper 910 of the vial 900 . The spike 1000 is a known medical part that inserts into a rubber stopper 910 such as a bottle-type ring or vial 900 to extract internal medicines or vice versa to create a flow path for introducing medicines. In the illustrated embodiment, the spike fixing part 200 fixes the spike 1000 as a casement type clamp, but the configuration of the spike fixing part 200 is also not limited to the illustrated clamp structure. In addition, the present invention also discloses an embodiment in which a special needle-shaped spike 1000 capable of removing the pressure change occurring inside the vial 900 is applied, and the specific configuration of the spike 1000 is described in the corresponding paragraph. Explain in detail.

The spike up and down driver 300 is configured to move the spike fixing part 200 in the vertical direction with respect to the vial fixing part 100. That is, the spike up and down driving unit 300 automatically inserts or removes the spike 1000 mounted on the spike fixing unit 200 into the rubber stopper 910 of the vial 900 mounted on the vial fixing unit 100. It is a configuration performed by That is, the spike 1000 penetrates the rubber stopper 910 of the vial 900 by the downward motion of the spike fixing unit 200 to maintain a fixed state. Therefore, the injection preparation device 10 of the present invention provides very safe working conditions by eliminating human intervention in the operation of inserting or removing the spike 1000 from the vial 900 containing the toxic anticancer agent or contrast agent. do.

According to the illustrated embodiment, the spike up and down driving unit 300 is composed of a stepping motor, a screw, and a nut member screwed to the screw, and a screw rotated by the stepping motor is coupled to the spike fixing unit 200. The rotational motion of the stepping motor is converted into linear motion of the fixing spike 200 by forming a screw connection with. However, other known mechanisms for converting rotational motion (or rotational motion) into linear motion, such as a rack and pinion mechanism or a link mechanism, may also be applied.

The operation of the spike up/down driver 300 is controlled by the control panel 800 . For example, when a corresponding button provided on the control panel 800 is pressed, the upward or downward movement of the spike up and down driving unit 300 occurs for a predetermined time or distance.

And, the cylinder pump 500 is a configuration that is essential to the injection preparation device 10 of the present invention and can also function as an independent device. The cylinder pump 500 is equipped with a cylinder cartridge 600 that introduces and discharges external fluid through a change in cylinder volume caused by a relatively fixed and rotating operation of a pair of pistons provided therein, and the cylinder cartridge 600 (600) Independently drive a pair of pistons provided inside. The configuration and operation of the cylinder pump 500 will be described in detail. However, the configuration of the cylinder pump 500 will be briefly described to the extent necessary for understanding the present invention.

Figure 3 is a view showing the overall appearance of the cylinder pump 500, a state in which the front cover 510 is opened. When the front cover 510 is opened, the cylinder cartridge 600 shown in FIG. 4 can be coupled, and FIG. 5 (b) shows a state in which the cylinder cartridge 600 is coupled into the cylinder pump 500. For reference, the cylinder cartridge 600 is fixed by an auto-lock function, and thus the cylinder cartridge 600 coupled with the driving shaft 522 is fixed so as not to move during operation. Hereinafter, the cylinder cartridge 600, its driving unit 520, and its operating principle will be described.

Referring to FIG. 4, the cylinder cartridge 600 has a structure in which an upper housing 610 and a lower housing 620 are sealed and coupled to form one housing, and an upper rotating body 614 and a lower rotating body 622 are formed therein. are coaxially aligned so that they can rotate independently of each other. The upper rotator 614 and the lower rotator 622 each form a truncated cone shape, and the vertex portions of each truncated cone (the vertex extending the generatrix) are arranged to face each other, creating a concave space between them and the housing. form This annular space is used as the cylinder space 630.

Upper and lower fastening members 618 and 626 are integrally formed on the slopes of the upper and lower rotating bodies 622, respectively, and the upper fastening member 618 has a first piston 640 and a lower fastening member 626. ) The second piston 642 is coupled. The first piston 640 and the second piston 642 are made of a material that has elasticity and can be deformed to adhere closely to the surrounding surface, such as a rubber packing coupled to the tip of a conventional syringe. That is, the first piston 640 and the second piston 642 are in close contact with the inner circumferential surface of the housing, and the annular cylinder space 630 partially moves according to the rotational motion of the first piston 640 or the second piston 642. As a result, negative and positive pressures can be formed. For reference, an annular member not shown in FIG. 4 is a sealing member for sealing.

In addition, the lower housing 620 is provided with an inlet pipe 650 and an outlet pipe 652, and tubes are inserted into the inlet pipe 650 and the outlet pipe 652, respectively. In addition, a drive shaft insertion hole 612 is formed in the center of the upper housing 610, and a first drive shaft fastening hole 616 is formed in the upper rotating body 614 coaxially with the drive shaft insertion hole 612. And, a second driving shaft fastening hole 624 is formed in the lower rotating body 622 . Here, the first driving shaft fastening hole 616 is larger than the second driving shaft fastening hole 624 . In other words, it is possible to access the second driving shaft fastening hole 624 through the first driving shaft fastening hole 616 . In addition, the first driving shaft fastening hole 616 and the second driving shaft fastening hole 624 have directivity and are independent of each other. In the illustrated embodiment, the first driving shaft fastening hole 616 has a cross shape with different widths, and the second driving shaft fastening hole 624 has a T shape.

Referring to (a) of Figure 5, there is a drive shaft 522 is shown in the central portion of the cartridge mounting groove 512, the cylinder drive unit 520 disposed in the main body of the cylinder pump 500 is shown in Figures 6 and 7 has been Two drive motors are provided in the cylinder drive unit 520, and the first drive shaft 538 and the second drive shaft 548, which are individually operated by each drive motor, have a second drive shaft 538 in the first drive shaft 538 while the rotation axes coincide. As a dual shaft structure in which the drive shaft 548 is inserted, it constitutes one drive shaft 522 outwardly.

7 is an exploded perspective view of the cylinder driving unit 520. The first and second driving units 530 and 540 each have a worm gear structure. The first driving unit 530 includes a first driving motor 532, a first worm 534 coupled to a shaft of the first driving motor 532, and a first worm gear 536 meshing with the first worm 534. Including, the first driving shaft 538 extends in a direction perpendicular to the gear of the first worm gear (536). The second driving unit 540 also has the same structure as the second driving motor 542, the second worm 544, the second worm gear 546, and the second driving shaft 548.

In particular, the cylinder drive unit 520 of FIG. 7 has a dual shaft structure in which the second drive shaft 548 is inserted into the first drive shaft 538. That is, the first driving shaft 538 forms a hollow shaft, and the second driving shaft 548 enters therein and protrudes further. Even if this dual shaft structure is achieved, since the first and second driving units 530 and 540 have a worm gear structure, even if one of the first driving shaft 538 or the second driving shaft 548 rotates, the other driving shaft rotates. can't make it Thus, the first driving shaft 538 and the second driving shaft 548 operate independently.

4, 6 and 7 together, the outer surface of the first drive shaft 538 corresponds to the shape of the first drive shaft fastening hole 616 formed in the upper rotating body 614 of the cylinder cartridge 600, , The end of the second driving shaft 548 corresponds to the shape of the second driving shaft fastening hole 624 formed in the lower rotating body 622 . Also, the first driving shaft fastening hole 616 is larger than the second driving shaft fastening hole 624 , and the second driving shaft 548 protrudes more than the first driving shaft 538 . Therefore, when the cylinder cartridge 600 is mounted in the cartridge mounting groove 512, the second drive shaft 548 passes through the first drive shaft fastening hole 616 through the drive shaft insertion hole 612 of the cylinder cartridge 600, It is bound to the second driving shaft fastening hole 624 of the lower rotating body 622 located further inside, and the first driving shaft 538 is bound to the first driving shaft fastening hole 616. Since the first driving shaft 538 and the second driving shaft 548 operate independently, the first piston 640 coupled to the upper rotating body 614 by the first driving unit 530 rotates independently, and the lower rotation The second piston 642 coupled to the whole 622 may also rotate independently by the second driving unit 540 .

The principle of operation of the cylinder pump 500 of FIGS. 3 to 7 having such a structure is shown in FIG. 8 .

The illustrated cylinder pump 500 controls the rotational operation of the first piston 640 and the second piston 642 of the cylinder cartridge 600 through the operation of the driving unit 520, so that the injection passes through the cylinder cartridge 600. Outflow, i.e. infusion into the patient. The inhalation and discharge of such an injection are composed of an infusion cycle and an alternation cycle.

For example, when the cylinder pump 500 is initially driven, the control unit of the cylinder pump 500 controls the injection stroke, as shown in (a) of FIG. 652), and the first piston 640, which was located on the side of the inlet pipe 650, rotates counterclockwise to the cylinder space 630 between the first piston 640 and the second piston 642. A negative pressure is created. The injection is introduced into the cylinder cartridge 600 through the inlet pipe 650 by this negative pressure.

And, as the first piston 640 continues to rotate counterclockwise as shown in (b) and (c) of FIG. 8, the injection is introduced into the cylinder through the inlet pipe 650, and the injection inside the cylinder The movement (inflow and outflow) of the injection flowing out of the cylinder cartridge 600 through the outflow pipe 652 continues.

Thereafter, when the first piston 640 rotates and is located in the outflow pipe 652 as shown in (d) of FIG. 8, the injection agent in the cylinder does not flow out. At this point, the controller controls the first piston 640 and the second By simultaneously driving the piston 642, the first piston 640 is positioned between the inlet pipe 650 and the outlet pipe 652 where the second piston 642 was previously located, as shown in (e) of FIG. 8, The second piston 642 performs counterclockwise rotation control. That is, alternate stroke control in which the first piston 640 and the second piston 642 change their roles (fixation and rotation) is performed.

After this alternating stroke control is performed, the injection stroke control in which the second piston 642 rotates counterclockwise as shown in (f) and (g) of FIG. 8 while the first piston 640 is fixed is performed again. It goes on. Of course, as shown in (h) of FIG. 8, when the second piston 642 rotates to the outlet pipe 652, the shift stroke control proceeds once again, and the role of the first piston 640 and the second piston 642 this is alternated

The inflow and outflow of the injection by the injection stroke performed by the first and second pistons 640 and 642 corresponds to the volume of the cylinder corresponding to the rotation angle of the rotating piston. Therefore, by controlling the rotation speed and rotation angle of the first drive motor 532 and the second drive motor 542, it is possible to accurately maintain the injection speed and injection amount of the injection discharged by the cylinder pump 500 (for example, The first drive motor 532 and the second drive motor 542 may be configured as encoder motors). That is, the cylinder pump 500 described above can accurately control the flow rate and flow rate of the injection passing through the cylinder cartridge 600 according to the set value, which means that the cylinder pump 500 in the present invention It means that it has a bolus function that accurately injects into the patient at the injection speed and injection amount.

This cylinder pump 500 has several advantages in addition to being able to accurately perform the bolus function. One advantage thereof is that the cylinder cartridge 600 constitutes an independent closed system. That is, by connecting the infusion tube and the injection pack to the inlet tube 650 and the outlet tube 652 around the cylinder cartridge 600, it can be mounted and used in any cylinder pump 500. This can be used as an injection at any time by combining the cylinder cartridge 600, an infusion set, and various medicines such as anticancer drugs in a kit form in a clean environment, so problems such as contamination or infection are fundamentally improved.

Another is that the operation of the cylinder pump 500 is achieved through the rotational motion of the first/second pistons 140 and 142 provided in the cylinder cartridge 600 . Therefore, unlike the conventional syringe pump, there is no need to replace the syringe even when used for a long time for a patient for more than several days, and also, like an infusion pump, to avoid fluctuations in the injection amount due to deformation of the fluid tube, the position where the fluid tube is pressed is adjusted periodically. It is also a great advantage that it can be used continuously for a very long time without interruption because it is not needed.

Then, the cylinder pump 500 is connected to the spike 1000 and the fluid pack 1200 through the tube and valve assembly 700 as follows to form one flow path. The configuration of the tube and valve assembly 700 may refer to FIG. 2 .

The tube and valve assembly 700 selectively selects the first tube 720 connected to the outlet pipe of the cylinder cartridge 600 and any one of the two inlet channels 712 and 714 as the outlet channel 716. A 3-way valve 710 connected to the 3-way valve 710, a second tube 730 connected to the inlet pipe of the cylinder cartridge 600 through the outflow passage 716 of the 3-way valve 710, and the first of the 3-way valve 710 It includes a third tube 740 connected to the first inflow passage 712, and the second inflow passage 714 of the 3-way valve 710 is connected to the spike 1000. The first tube 720 and the third tube 740 are connected to the transfusion pack 1200.

Cylinder pump 500 extracts the sap from the sap pack 1200 through the tube and valve assembly 700, or performs an operation of injecting the medicine into the sap pack 1200. This process is determined by the opening direction of the 3-way valve 710, and the cylinder pump 500 performs suction and discharge operations according to a preset capacity and speed. The injection preparation device 10 of the present invention is largely divided into a priming process and a chemical solution injection process.

The priming process is a process of discharging air from the inner space of the tube and valve assembly 700 and filling the fluid. In other words, the priming process may be referred to as a preparation process for extracting the medicine inside the vial 900 in an accurate capacity and injecting it into the sap pack 1200.

In the priming process, the 3-way valve 710 is connected to the first tube 720 and the third tube 740, the fluid pack 1200 and the second tube 730 form a circulation circuit. That is, the tube and valve assembly 700 forms a circulation circuit between the cylinder pump 500 and the fluid pack 1200, and in this state, the control unit of the cylinder pump 500 pre-transmits the fluid in the fluid pack 1200. By inflow and outflow through the cylinder cartridge 600 at the set amount and speed, the air in the tube and valve assembly 700 is discharged and the fluid is filled. Here, it may be preferable that the flow rate of the fluid is set to correspond to the volume of the tube and valve assembly 700 .

After the priming process, a drug solution injection process is performed. In the drug solution injection process, the tube and valve assembly 700 includes the 3-way valve 710, the vial 900 into which the spike 1000 is inserted, and the second tube 730 and a closed circuit to which the first tube 720 is connected. That is, in the course of drug solution injection, a one-way circuit is formed in which the medicine inside the vial 900 is introduced into the infusion pack 1200 through the cylinder pump 500, and this one-way circuit forms a closed circuit sealed against the outside. By forming, there is no leakage of medicine to the outside. During the drug solution injection process, the control unit introduces the drug into the infusion pack 1200 by allowing the drug in the vial 900 to flow in and out through the cylinder cartridge 600 at a preset amount and speed.

Here, in one embodiment of the present invention, several additional configurations for effectively extracting the medicine contained in the vial 900 may be further included.

One is to prevent air from entering the spike 1000 by taking a reverse posture of turning the vial 900 upside down during the drug injection process, that is, the process of introducing the medicine in the vial 900 into the infusion pack 1200. is to do To this end, the vial fixing unit 100, the spike fixing unit 200, and the spike up and down driving unit 300 are fixed to one coupling plate 410, and the coupling plate 410 is in an inverted position by the rotation driving unit 400. , and the control panel 800 controls the operation of the rotary drive unit 400. 9 shows a state in which the vial 900 is inverted by the rotation drive unit 400.

The other relates to Spike 1000. Positive or negative pressure fluctuations accompany the entry and exit of the drug to be contained in an airtight container such as the vial 900. Such pressure fluctuations cause an excessive load on the cylinder pump 500, preventing extraction of an accurate amount. In addition, the negative pressure generated inside the vial 900 is likely to cause problems such as creating air bubbles inside the syringe. The spike 1000 applied to one embodiment of the present invention ensures smooth operation of the cylinder pump 500 by offsetting these pressure fluctuations.

These special spikes 1000 can be called needle-type spikes, and the configuration of the needle-type spikes 1000 is shown in FIG. 10 . The illustrated spike 1000 includes a first flow path 1110, one end of which communicates with the air vent hole 1130, and a second flow path 1120 that is separated from the first flow path 1110 and is capable of entering and exiting the drug. It is provided with a spike body 1100 that does. In addition, the first needle 1140 is coupled to the other end of the first flow path 1110 and protrudes out of the spike body 1100, and the second needle 1150 is coupled to one end of the second flow path 1120 to make the first needle 1150. 1 protrudes to the outside of the spike body 1100 toward the same direction as the needle (1140). In addition, the shown spike 1000 is coupled to the spike body 1100 so as to communicate with the other end of the second flow path 1120, and is opened only when the second inflow path 714 of the 3-way valve 710 is inserted. and a female swivel valve 1160 having valve means.

According to the spike 1000 having this configuration, through the first flow path 1110 and the first needle 1140 communicating with the air vent hole 1130 automatically by the pressure difference between the inside and outside of the vial 900. When external air is introduced into the vial 900 (at negative pressure) or when the air inside the vial 900 flows out (at positive pressure), the pressure inside the vial 900 changes automatically and immediately. this cancels out FIG. 11 is a diagram illustrating a pressure offset effect when extracting a drug inside a vial 900 using the spike 1000 of FIG. 10 .

In addition, the length of the first needle 1140 may be longer than the length of the second needle 1150, and in particular, the length of the second needle 1150 may correspond to the thickness of the rubber stopper 910 of the vial 900. can

Making the length of the first needle 1140 longer allows the first needle 1140 to enter deeply into the vial 900 when the vial 900 is inverted, so that air can flow in and out smoothly, In addition, this is to create a stable supporting force in which the short second needle 1150 does not escape from the vial 900.

In addition, shortening the length of the second needle 1150 to the extent corresponding to the thickness of the rubber stopper 910 sealing the vial 900 is to maximize the extraction of the drug contained in the vial 900 without any residual amount. As the drug can be extracted as much as possible, the expensive drug in the vial 900 can be economically used, the waste drug is minimized and environmental pollution is suppressed, and it is very advantageous in terms of economic feasibility, such as waste drug treatment cost and waste drug saving. It happens.

The above description is merely an example of the technical idea of the present invention, and various modifications and variations can be made to those skilled in the art without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention, but to explain, and the scope of the technical idea of the present invention is not limited by these embodiments.

10: injection preparation device 100: vial fixing unit
200: spike fixing part 300: spike up and down driving part
400: rotation drive unit 410: coupling plate
500: cylinder pump 510: cover
512: cartridge mounting groove 520: cylinder driving unit
522: drive shaft 530: first drive unit
532: first drive motor 534: first worm
536: first worm gear 538: first drive shaft
540: second driving unit 542: second driving motor
544: second worm 546: second worm gear
548: second drive shaft 600: cylinder cartridge
610: upper housing 612: drive shaft insertion hole
614: upper rotating body 616: first drive shaft fastening hole
618: upper fastening member 620: lower housing
622: lower rotating body 624: second drive shaft fastening hole
626: lower fastening member 630: cylinder space
640: first piston 642: second piston
650: inlet pipe 652: outlet pipe
700: tube and valve assembly 710: 3-way valve
712: first inflow passage 714: second inflow passage
716: outlet flow path 720: first tube
730: second tube 740: third tube
800: control panel 900: vial
910: rubber stopper 1000: spike
1100: spike body 1110: first euro
1120: second flow path 1130: air vent hole
1140: first needle 1150: second needle
1160: swivel valve 1200: sap pack

Claims (12)

A vial fixing unit for fixing a vial in which the medicine is enclosed and having a rubber stopper;
A spike fixing part for fixing a spike forming a flow path through the rubber stopper of the vial;
a spike up and down driving unit for moving the spike fixing unit in an up and down direction with respect to the vial fixing unit;
a control panel for controlling the operation of the spike up/down driver;
A cylinder cartridge that introduces and discharges external fluid through a change in cylinder volume caused by relatively fixed and rotating motions of a pair of pistons provided inside is mounted, and a pair of pistons provided inside the cylinder cartridge Cylinder pump independently driven; and
A first tube connected to the outlet pipe of the cylinder cartridge, a 3-way valve selectively connecting one of the two inlet passages to the outlet passage, and an outlet passage of the 3-way valve connected to the inlet pipe of the cylinder cartridge. a tube and valve assembly including a second tube connected to and a third tube connected to the first inflow path of the 3-way valve, wherein the second inflow path of the 3-way valve is connected to the spike;
Injection preparation device comprising a. According to claim 1,
The injection preparation device, characterized in that the spike penetrates the rubber stopper of the vial and maintains a fixed state by the descending operation of the spike fixing part. According to claim 2,
The vial fixing part, the spike fixing part, and the spike up and down driving part are fixed to one coupling plate,
The coupling plate can be rotated in an inverted posture by a rotation drive unit,
The injection preparation device, characterized in that the control panel controls the operation of the rotary drive unit. According to claim 1,
Injection preparation device, characterized in that the infusion pack is connected to the first tube and the third tube. According to claim 1,
The spike,
A spike body having a first passage communicating with an air vent hole and one end thereof, and a second passage separated from the first passage and allowing entry and exit of the drug;
a first needle coupled to the other end of the first channel and protruding out of the spike body;
a second needle coupled to one end of the second channel and protruding out of the spike body in the same direction as the first needle; and
a female swivel valve coupled to the spike body so as to communicate with the other end of the second flow path and having a valve means opened only when the second inflow path of the 3-way valve is inserted;
An injection preparation device comprising a. According to claim 5,
An injection preparation device, characterized in that the length of the first needle is longer than the length of the second needle. According to claim 6,
The injection preparation device, characterized in that the length of the second needle corresponds to the thickness of the rubber stopper of the vial. According to claim 1,
The cylinder cartridge,
An upper rotating body and a lower rotating body freely rotating with each other,
An annular cylinder space is formed between the upper rotating body and the lower rotating body,
A first piston of the pair of pistons is coupled to the upper rotating body to rotate along the cylinder space, and a second piston is coupled to the lower rotating body to rotate along the cylinder space. Injectable preparation device to be. According to claim 8,
The cylinder pump includes a cylinder driving unit for independently driving a pair of pistons provided in the cylinder cartridge and a control unit for controlling the cylinder driving unit,
The control unit controls the amount and speed of the liquid flowing in and out through the cylinder cartridge to a preset value. According to claim 9,
In a state where the 3-way valve, the fluid pack connected to the first tube and the third tube and the second tube form a circulation circuit,
The control unit is configured to discharge air in the tube and valve assembly by inflow and outflow of the infusion in the infusion pack through the cylinder cartridge at a preset amount and speed. According to claim 10,
In a state where the 3-way valve forms a closed circuit in which the vial into which the spike is inserted, the second tube, and the first tube are connected,
The control unit introduces the medicine in the vial into the infusion pack by inflow and outflow through the cylinder cartridge at a preset amount and speed. According to claim 11,
Introduction of the medicine in the vial into the infusion pack is an injection preparation device, characterized in that the vial is made in an inverted state.

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