KR20230056879A - Biodegradable microcapsules and manufacturing method of the same - Google Patents

Abstract

The present invention relates to a capsule having a shape in which a capsule wall surrounds an oil phase of a core material, and specifically, to a biodegradable microcapsule in which a biodegradable polymer formed by a reaction of a biodegradable lipid-based material and an aliphatic isocyanate monomer forms the capsule wall of the capsule, and which has a size of 0.1 to 300 ㎛, and a manufacturing method thereof. According to the present invention, the capsule decomposes in nature and does not pollute the environment, and no harmful components remain in the human body to be harmless to the human body, such as the skin, and the core material can be captured inside the biodegradable capsule wall to achieve a stabilized state.

Description

Biodegradable microcapsules and manufacturing method of the same

The present invention relates to a biodegradable capsule and a manufacturing method thereof, and more particularly, to a biodegradable capsule wall that is degradable in nature and does not pollute the environment, and is harmless to the human body such as the skin because there is no residual component harmful to the human body. It relates to biodegradable microcapsules in which core substances are collected and stabilized, and a manufacturing method thereof.

The environmental pollution of microplastics, which has recently become a global issue, has reached a situation where it destroys the marine ecosystem and further affects the human table. Accordingly, international organizations and countries have begun to put a brake on the production and sale of microplastics, and unless alternative materials are found, it is becoming difficult to impart functionality by using particle-type materials to functional chemical materials used in various industries.

In addition, in Korea, the safety of chemical materials applied to various industrial materials and materials parts is being strengthened while experiencing side effects such as biocides.

Existing microcapsules are mostly made of plastic materials and contain harmful substances such as formaldehyde and organic solvents.

On the other hand, development fields related to biodegradable materials have been concentrated on biodegradable resins or drug delivery systems so far, and the shape of particles is made in the form of liposomes, beads, and emulsions through multi-layer coating or ion gelation reaction using natural materials. there is. In the case of manufacturing biodegradable microcapsules with biodegradable materials, they are made by methods such as dropping, micro-fluid system, and multi-layer coating. These methods include wall components of microcapsules. It is difficult to secure the productivity or stability of microcapsules due to limitations in manufacturing methods and limitations of manufacturing methods.

Therefore, there is a demand for the development of a new concept capsule that does not pollute the environment, does not harm the human body, and has improved performance compared to existing biodegradable capsules.

Republic of Korea Patent Registration No. 10-1366307

The problem to be solved by the present invention is that it is decomposed in nature, does not pollute the environment, does not remain harmful to the human body, is harmless to the human body such as the skin, and core substances are collected inside the biodegradable capsule wall to achieve a stable state. It is to provide a biodegradable microcapsule and a manufacturing method thereof.

The present invention is a capsule having a shape in which the capsule wall surrounds the oil phase of the core material, and a biodegradable polymer formed by reacting a biodegradable lipid-based material with an aliphatic isocyanate monomer constitutes the capsule wall of the capsule, and the capsule has a 0.1 Biodegradable microcapsules with a size of -300 μm are provided.

The biodegradable lipid-based material may include at least one material selected from the group consisting of sphingo lipid-based materials, glycolipid-based materials, sphingo-glycolipid-based materials, and phospholipid-based materials.

The sphingolipid-based material may include ceramide, phytoceramide, sphingomyelin, cerebroside, ganglioside, or a mixture thereof.

The glycolipid-based material may include glycerol glycolipids, galatolipids, sulfolipids, or mixtures thereof.

The sphingo glycolipid-based substance is glycolipid, cerebroside, glucocerebroside, monoglycosylceramide, galactocerebroside, glucose cerebroside, It may include sulfatide (sulfated galactocerebroside), ganglioside, globoside, or mixtures thereof.

The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin, cephalin or Mixtures of these may be included.

The aliphatic isocyanate monomer is 4,4'-dicyclohexylmethane diisocyanate, trans-1,4-cyclohexane diisocyanate, isophorone Isophorone diisocyanate, Hexamethylene diisocyanate, Trimethyl hexamethylene diisocyanate, 1,3-Bis(Isocyanomethyl)cyclohexane ), 2.4-diisocyanato cyclohexane, 1,6-diisocyanato-2,2,4-trimethylhexane, 1,6-diisocyanato-2,4,4-trimethylhexane (1,6-diisocyanato-2,4,4-trimethylhexane), 1-isocyanatomethyl-3-isocyanato-l, 5,5-trimethylcyclohexane (1-isocyanatomethyl-3-isocyanato-l,5,5-trimethyl cyclohexane), tetramethoxybutane 1,4- diisocyanate, butane 1,4- Butane 1,4-diisocyanate, hexane 1,6- diisocyanate, dicyclohexylmethane diisocyanate and cyclohexane 1,4-diisocyanate 4-diisocyanate) may include one or more materials selected from the group consisting of.

The core material may include at least one phase change material selected from the group consisting of nonadecane, octadecane, heptadecane, hexadecane, tetradecane, pentadecane stearic acid, cyanamide, propyl amide, and pentaerythritol.

The heart substance includes at least one fat-soluble vitamin selected from the group consisting of α-carotene, β-carotene, retinol, tretinoin, alphacalcidol, dihydrotakisterol, calcipotriol, tocopherol, naphthoquinone, and phylloquinone. can do.

The core material may include a phase change material (PCM), a fat-soluble vitamin, a functional fragrance, a functional oil, or a mixture thereof.

In addition, the present invention is a method for manufacturing a capsule having a shape in which the capsule wall surrounds the oil phase of the core material, comprising the steps of mixing the core material, a biodegradable lipid-based material and an aliphatic isocyanate monomer, Mixing and emulsifying an aqueous solution of a phospholipid-based material capable of emulsifying the core material with a mixture of a lipid-based material and an aliphatic-based isocyanate monomer to form an oil/aqueous phase emulsion, while stirring by applying heat to the oil/water phase emulsion Reacting to form a capsule and mixing a protective colloid compound with the reaction product, wherein the biodegradable polymer formed by reacting the biodegradable lipid-based material with the aliphatic isocyanate monomer forms the capsule wall of the capsule, The capsule provides a method for producing biodegradable microcapsules having a size of 0.1 to 300 μm.

The biodegradable lipid-based material may include at least one material selected from the group consisting of sphingo lipid-based materials, glycolipid-based materials, sphingo-glycolipid-based materials, and phospholipid-based materials.

The sphingolipid-based material may include ceramide, phytoceramide, sphingomyelin, cerebroside, ganglioside, or a mixture thereof.

The glycolipid-based material may include glycerol glycolipids, galatolipids, sulfolipids, or mixtures thereof.

The sphingo glycolipid-based substance is glycolipid, cerebroside, glucocerebroside, monoglycosylceramide, galactoserebroside, glucose cerebroside, sulfatide ( sulfatide or sulfurized galactocerebroside), ganglioside, globoside, or mixtures thereof.

The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin, cephalin or Mixtures of these may be included.

The aliphatic isocyanate monomer is 4,4'-dicyclohexylmethane diisocyanate, trans-1,4-cyclohexane diisocyanate, isophorone Isophorone diisocyanate, Hexamethylene diisocyanate, Trimethyl hexamethylene diisocyanate, 1,3-Bis(Isocyanomethyl)cyclohexane ), 2.4-diisocyanato cyclohexane, 1,6-diisocyanato-2,2,4-trimethylhexane, 1,6-diisocyanato-2,4,4-trimethylhexane (1,6-diisocyanato-2,4,4-trimethylhexane), 1-isocyanatomethyl-3-isocyanato-l, 5,5-trimethylcyclohexane (1-isocyanatomethyl-3-isocyanato-l,5,5-trimethyl cyclohexane), tetramethoxybutane 1,4- diisocyanate, butane 1,4- Butane 1,4-diisocyanate, hexane 1,6- diisocyanate, dicyclohexylmethane diisocyanate and cyclohexane 1,4-diisocyanate 4-diisocyanate) may include one or more materials selected from the group consisting of.

The biodegradable lipid-based material is preferably mixed in an amount of 1 to 20 parts by weight based on 100 parts by weight of the core material.

It is preferable to mix 0.1 to 10 parts by weight of the aliphatic isocyanate monomer based on 100 parts by weight of the core material.

The aqueous solution of the phospholipid-based material may be an aqueous solution prepared by mixing 1 to 10 parts by weight of the phospholipid-based material with respect to 100 parts by weight of the core material and adding 10 to 90 parts by weight of water with respect to 100 parts by weight of the core material.

The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin and cephalin. It may include one or more materials selected from the group consisting of.

The protective colloidal compound may include a material having a hydroxy group or an amine group capable of reacting with the aliphatic isocyanate monomer.

The core material may include at least one phase change material selected from the group consisting of nonadecane, octadecane, heptadecane, hexadecane, tetradecane, pentadecane stearic acid, cyanamide, propyl amide, and pentaerythritol.

The heart substance includes at least one fat-soluble vitamin selected from the group consisting of α-carotene, β-carotene, retinol, tretinoin, alphacalcidol, dihydrotakisterol, calcipotriol, tocopherol, naphthoquinone, and phylloquinone. can do.

The core material may include a phase change material (PCM), a fat-soluble vitamin, a functional fragrance, a functional oil, or a mixture thereof.

According to the present invention, it is decomposed in nature and does not pollute the environment, and no components harmful to the human body remain, so it is harmless to the human body such as the skin, and the core material is collected inside the biodegradable capsule wall to form a stable state.

According to the present invention, by encapsulating and stabilizing unstable fragrances or functional oils that can be easily volatilized in air or deteriorated due to oxidation, it is possible to improve the instability problem that occurs when applying unstable fragrances or functional oils to chemical household products, cosmetic formulations, etc. and the effectiveness of the product can last for a long time.

A biodegradable microcapsule having a biodegradable capsule wall is stabilized by collecting core material therein. These biodegradable microcapsules can be widely applied not only as materials for chemical products such as building and civil engineering materials, liquid detergents, and fabric softeners, but also as liquid-type cosmetic materials such as liquid-type shampoo and body soap for personal care. .

1 is a view showing a biodegradable microcapsule according to a preferred embodiment of the present invention.

Hereinafter, preferred embodiments according to the present invention will be described in detail with reference to the accompanying drawings. However, the following embodiments are provided to those skilled in the art to sufficiently understand the present invention, and may be modified in various forms, and the scope of the present invention is limited to the following examples. it is not going to be

When it is said that any one component "includes" another component in the detailed description or claims of the invention, it is not construed as being limited to only the corresponding component unless otherwise stated, and other components are not further defined. It should be understood that it can include.

The present invention is degraded in nature after use and does not pollute the environment, does not remain harmful to the human body, is harmless to the human body such as the skin, and has improved physicochemical properties, economic feasibility and usability compared to existing biodegradable capsules. Microcapsules and their manufacturing method are presented.

The biodegradable microcapsule according to a preferred embodiment of the present invention is a capsule having a shape in which the capsule wall surrounds the oil phase of the core material, and the biodegradable polymer formed by reacting the biodegradable lipid-based material with the aliphatic isocyanate monomer is the capsule. forming a capsule wall, and the capsule may have a size of 0.1 to 300 μm.

The biodegradable lipid-based material may include at least one material selected from the group consisting of sphingo lipid-based materials, glycolipid-based materials, sphingo-glycolipid-based materials, and phospholipid-based materials.

The sphingolipid-based material may include ceramide, phytoceramide, sphingomyelin, cerebroside, ganglioside, or a mixture thereof.

The glycolipid-based material may include glycerol glycolipids, galatolipids, sulfolipids, or mixtures thereof.

The sphingo glycolipid-based substance is glycolipid, cerebroside, glucocerebroside, monoglycosylceramide, galactocerebroside, glucose cerebroside, It may include sulfatide (sulfated galactocerebroside), ganglioside, globoside, or mixtures thereof.

The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin, cephalin or Mixtures of these may be included.

The aliphatic isocyanate monomer is 4,4'-dicyclohexylmethane diisocyanate, trans-1,4-cyclohexane diisocyanate, isophorone Isophorone diisocyanate, Hexamethylene diisocyanate, Trimethyl hexamethylene diisocyanate, 1,3-Bis(Isocyanomethyl)cyclohexane ), 2.4-diisocyanato cyclohexane, 1,6-diisocyanato-2,2,4-trimethylhexane, 1,6-diisocyanato-2,4,4-trimethylhexane (1,6-diisocyanato-2,4,4-trimethylhexane), 1-isocyanatomethyl-3-isocyanato-l, 5,5-trimethylcyclohexane (1-isocyanatomethyl-3-isocyanato-l,5,5-trimethyl cyclohexane), tetramethoxybutane 1,4- diisocyanate, butane 1,4- Butane 1,4-diisocyanate, hexane 1,6- diisocyanate, dicyclohexylmethane diisocyanate and cyclohexane 1,4-diisocyanate 4-diisocyanate) may include one or more materials selected from the group consisting of.

The core material may include at least one phase change material selected from the group consisting of nonadecane, octadecane, heptadecane, hexadecane, tetradecane, pentadecane stearic acid, cyanamide, propyl amide, and pentaerythritol.

The heart substance includes at least one fat-soluble vitamin selected from the group consisting of α-carotene, β-carotene, retinol, tretinoin, alphacalcidol, dihydrotakisterol, calcipotriol, tocopherol, naphthoquinone, and phylloquinone. can do.

The core material may include a phase change material (PCM), a fat-soluble vitamin, a functional fragrance, a functional oil, or a mixture thereof.

A method for manufacturing biodegradable microcapsules according to a preferred embodiment of the present invention is a method for manufacturing a capsule having a shape in which the capsule wall surrounds the oil phase of the core substance, the core substance, the biodegradable lipid-based substance and the aliphatic isocyanate monomer. Mixing and emulsifying an aqueous solution of a phospholipid-based material capable of emulsifying the core material with a mixture of a core material, a biodegradable lipid-based material, and an aliphatic isocyanate monomer to form an oil/water phase emulsion; Biodegradation formed by reacting a biodegradable lipid-based material with an aliphatic isocyanate monomer, comprising a step of reacting with stirring while applying heat to the oil/aqueous emulsion to form a capsule and mixing a protective colloid compound with the reaction product A sex polymer forms the capsule wall of the capsule, and the capsule may have a size of 0.1 to 300 μm.

The biodegradable lipid-based material may include at least one material selected from the group consisting of sphingo lipid-based materials, glycolipid-based materials, sphingo-glycolipid-based materials, and phospholipid-based materials.

The sphingolipid-based material may include ceramide, phytoceramide, sphingomyelin, cerebroside, ganglioside, or a mixture thereof.

The glycolipid-based material may include glycerol glycolipids, galatolipids, sulfolipids, or mixtures thereof.

The sphingo glycolipid-based substance is glycolipid, cerebroside, glucocerebroside, monoglycosylceramide, galactocerebroside, glucose cerebroside, It may include sulfatide (sulfated galactocerebroside), ganglioside, globoside, or mixtures thereof.

The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin, cephalin or Mixtures of these may be included.

The aliphatic isocyanate monomer is 4,4'-dicyclohexylmethane diisocyanate, trans-1,4-cyclohexane diisocyanate, isophorone Isophorone diisocyanate, Hexamethylene diisocyanate, Trimethyl hexamethylene diisocyanate, 1,3-Bis(Isocyanomethyl)cyclohexane ), 2.4-diisocyanato cyclohexane, 1,6-diisocyanato-2,2,4-trimethylhexane, 1,6-diisocyanato-2,4,4-trimethylhexane (1,6-diisocyanato-2,4,4-trimethylhexane), 1-isocyanatomethyl-3-isocyanato-l, 5,5-trimethylcyclohexane (1-isocyanatomethyl-3-isocyanato-l,5,5-trimethyl cyclohexane), tetramethoxybutane 1,4- diisocyanate, butane 1,4- Butane 1,4-diisocyanate, hexane 1,6- diisocyanate, dicyclohexylmethane diisocyanate and cyclohexane 1,4-diisocyanate 4-diisocyanate) may include one or more materials selected from the group consisting of.

The biodegradable lipid-based material is preferably mixed in an amount of 1 to 20 parts by weight based on 100 parts by weight of the core material.

It is preferable to mix 0.1 to 10 parts by weight of the aliphatic isocyanate monomer based on 100 parts by weight of the core material.

The aqueous solution of the phospholipid-based material may be an aqueous solution prepared by mixing 1 to 10 parts by weight of the phospholipid-based material with respect to 100 parts by weight of the core material and adding 10 to 90 parts by weight of water with respect to 100 parts by weight of the core material.

The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin and cephalin. It may include one or more materials selected from the group consisting of.

The protective colloidal compound may include a material having a hydroxy group or an amine group capable of reacting with the aliphatic isocyanate monomer.

The core material may include at least one phase change material selected from the group consisting of nonadecane, octadecane, heptadecane, hexadecane, tetradecane, pentadecane stearic acid, cyanamide, propyl amide, and pentaerythritol.

The heart substance includes at least one fat-soluble vitamin selected from the group consisting of α-carotene, β-carotene, retinol, tretinoin, alphacalcidol, dihydrotakisterol, calcipotriol, tocopherol, naphthoquinone, and phylloquinone. can do.

The core material may include a phase change material (PCM), a fat-soluble vitamin, a functional fragrance, a functional oil, or a mixture thereof.

Hereinafter, the biodegradable microcapsules according to a preferred embodiment of the present invention will be described in more detail.

1 is a view showing a biodegradable microcapsule according to a preferred embodiment of the present invention.

Referring to FIG. 1, the biodegradable microcapsule according to a preferred embodiment of the present invention is a capsule having a shape in which the capsule wall 10 surrounds the oil phase 20 of the core material, and includes a biodegradable lipid-based material and an aliphatic-based capsule. A biodegradable polymer formed by the reaction of isocyanate monomer forms the capsule wall 10 of the capsule, and the capsule has a diameter of 0.1 to 300 μm.

The core material may include a phase change material (PCM), a fat-soluble vitamin, a functional fragrance, a functional oil, or a mixture thereof.

The biodegradable microcapsules form a form in which phase change materials, fat-soluble vitamins, functional flavors, functional oils, or mixtures thereof are trapped inside the capsule walls as core substances.

The phase change material is a material used as a functional material for construction or civil engineering, such as nonadecane, octadecane, heptadecane, hexadecane, tetradecane, pentadecane stearic acid, cyanamide, propyl amide, pentaerythritol or mixtures thereof can be

The fat-soluble vitamin may be α-carotene, β-carotene, retinol, tretinoin, alphacalcidol, dihydrotakisterol, calcipotriol, tocopherol, naphthoquinone, phylloquinone, or mixtures thereof.

The functional flavor may be aroma herb flavor, rose flavor, jasmine flavor, lavender flavor, mint flavor, banana flavor, apple flavor, strawberry flavor, vanilla flavor, or a mixture thereof.

The functional oil may be natural oil, synthetic oil, oily oil, or a mixture thereof. The natural oils include hydrocarbon oils such as paraffin/squalane, jojoba oil, olive oil, herb oil, meadowfoam seed oil, rosehip oil, canola oil, camellia oil, argan oil, avocado oil, coconut oil, almond oil, and macadamia oil. , tea tree oil, eucalyptus oil, rosemary oil, lavender oil, or mixtures thereof. The synthetic oil may be a silicone-based oil such as ester-based oil, dimethicone, or methylpolysiloxane, or a mixture thereof. The oily oil is retinol, ceramide, ethylhexyl salicylate, ethylhexyl methoxycinnamate, alpha-bisabolol, oil-soluble licorice extract, tocopherol, vitamin-based oils such as retinol, adenosine, arbutin, carnosine, phenylethylreso Cynol, ethylhexyltriazone, ethylhexylmethoxycinnamate, ethylhexyl salicylate, octocrylene, isoamyl-p-methoxycinnamate, diethylhexyl 2,6-naphthalate, ethylhexylisononano It may be a material used as a raw material for household items such as cosmetics, personal care products, etc., such as eight or a mixture thereof. Adenosine, arbutin, carnosine, phenylethylresorcinol, etc. are used as cosmetic raw materials for wrinkle improvement and whitening improvement substances, and ethylhexyltriazone, ethylhexylmethoxycinnamate, ethylhexyl salicylate, octocrylene, isoamyl -p-Methoxycinnamate is used as a raw material for sunscreens, and diethylhexyl 2,6-naphthalate and ethylhexyl isononanoate are functional oils for skin softening and are used as raw materials for cosmetics.

The biodegradable polymer is formed by reacting a biodegradable lipid-based material with an aliphatic isocyanate monomer and forms the capsule wall 10 of the capsule. As will be described later, a portion of the phospholipid-based material contained in the aqueous solution of the phospholipid-based material added for emulsification during the manufacturing process may also react with the aliphatic isocyanate monomer to form the capsule wall 10 of the capsule.

The biodegradable lipid-based material may include at least one material selected from the group consisting of sphingo lipid-based materials, glycolipid-based materials, sphingo-glycolipid-based materials, and phospholipid-based materials.

The sphingolipid-based material may include ceramide, phytoceramide, sphingomyelin, cerebroside, ganglioside, or a mixture thereof.

The glycolipid-based material may include glycerol glycolipids, galatolipids, sulfolipids, or mixtures thereof.

The sphingo glycolipid-based substance is glycolipid, cerebroside, glucocerebroside, monoglycosylceramide, galactocerebroside, glucose cerebroside, It may include sulfatide (sulfatide or sulfurized galactocerebroside), ganglioside, globoside, or mixtures thereof.

The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine (PE), phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin, cephalin ), mixtures thereof, and the like.

The aliphatic isocyanate monomer is 4,4'-dicyclohexylmethane diisocyanate, trans-1,4-cyclohexane diisocyanate, isophorone Isophorone diisocyanate, Hexamethylene diisocyanate, Trimethyl hexamethylene diisocyanate, 1,3-Bis(Isocyanomethyl)cyclohexane ), 2.4-diisocyanato cyclohexane, 1,6-diisocyanato-2,2,4-trimethylhexane, 1,6-diisocyanato-2,4,4-trimethylhexane (1,6-diisocyanato-2,4,4-trimethylhexane), 1-isocyanatomethyl-3-isocyanato-l, 5,5-trimethylcyclohexane (1-isocyanatomethyl-3-isocyanato-l,5,5-trimethyl cyclohexane), tetramethoxybutane 1,4- diisocyanate, butane 1,4- Butane 1,4-diisocyanate, hexane 1,6- diisocyanate, dicyclohexylmethane diisocyanate and cyclohexane 1,4-diisocyanate 4-diisocyanate) may include one or more materials selected from the group consisting of.

The biodegradable polymer forming the capsule wall 10 is 2 to 80 parts by weight based on 100 parts by weight of the oil phase 20 (phase change material, fat-soluble vitamin, functional flavor, functional oil or mixture thereof) of the core material. , more preferably 5 to 50 parts by weight. If the biodegradable polymer is used less than the above range, it may be difficult to form a capsule by collecting the oil phase 20 of the core material, and if it is used too much, the particle size may become too large and agglomeration may occur.

Hereinafter, a method for preparing biodegradable microcapsules according to a preferred embodiment of the present invention will be described in more detail.

A core material, a biodegradable lipid-based material, and an aliphatic isocyanate monomer are mixed. This will be described in more detail.

Mix the core material and the biodegradable lipid-based material. The biodegradable lipid-based material is preferably mixed in an amount of 1 to 20 parts by weight based on 100 parts by weight of the core material.

The core material may include a phase change material (PCM), a fat-soluble vitamin, a functional fragrance, a functional oil, or a mixture thereof.

The phase change material is a material used as a functional material for construction or civil engineering, such as nonadecane, octadecane, heptadecane, hexadecane, tetradecane, pentadecane stearic acid, cyanamide, propyl amide, pentaerythritol or mixtures thereof can be

The fat-soluble vitamin may be α-carotene, β-carotene, retinol, tretinoin, alphacalcidol, dihydrotakisterol, calcipotriol, tocopherol, naphthoquinone, phylloquinone, or mixtures thereof.

The functional flavor may be aroma herb flavor, rose flavor, jasmine flavor, lavender flavor, mint flavor, banana flavor, apple flavor, strawberry flavor, vanilla flavor, or a mixture thereof.

The functional oil may be natural oil, synthetic oil, oily oil, or a mixture thereof. The natural oils include hydrocarbon oils such as paraffin/squalane, jojoba oil, olive oil, herb oil, meadowfoam seed oil, rosehip oil, canola oil, camellia oil, argan oil, avocado oil, coconut oil, almond oil, and macadamia oil. , tea tree oil, eucalyptus oil, rosemary oil, lavender oil, or mixtures thereof. The synthetic oil may be a silicone-based oil such as ester-based oil, dimethicone, or methylpolysiloxane, or a mixture thereof. The oily oil is retinol, ceramide, ethylhexyl salicylate, ethylhexyl methoxycinnamate, alpha-bisabolol, oil-soluble licorice extract, tocopherol, vitamin-based oils such as retinol, adenosine, arbutin, carnosine, phenylethylreso Cynol, ethylhexyltriazone, ethylhexylmethoxycinnamate, ethylhexyl salicylate, octocrylene, isoamyl-p-methoxycinnamate, diethylhexyl 2,6-naphthalate, ethylhexylisononano It may be a material used as a raw material for household items such as cosmetics, personal care products, etc., such as eight or a mixture thereof. Adenosine, arbutin, carnosine, phenylethylresorcinol, etc. are used as cosmetic raw materials for wrinkle improvement and whitening improvement substances, and ethylhexyltriazone, ethylhexylmethoxycinnamate, ethylhexyl salicylate, octocrylene, isoamyl -p-Methoxycinnamate is used as a raw material for sunscreens, and diethylhexyl 2,6-naphthalate and ethylhexyl isononanoate are functional oils for skin softening and are used as raw materials for cosmetics.

The core material is a functional material (phase change material) such as construction and civil engineering, functional fragrance, functional oil, fat-soluble vitamin, etc. required for cosmetics, personal care products, household goods, etc. If encapsulation is required, it is limited to the materials listed above It is not.

The biodegradable lipid-based material may include at least one material selected from the group consisting of sphingo lipid-based materials, glycolipid-based materials, sphingo-glycolipid-based materials, and phospholipid-based materials.

The sphingolipid-based material may be ceramide, phytoceramide, sphingomyelin, cerebroside, ganglioside, or a mixture thereof.

The glycolipid-based material may be a glycerol glycolipid, a galatolipid, a sulfolipid, or a mixture thereof.

The sphingo glycolipid-based substance is glycolipid, cerebroside, glucocerebroside, monoglycosylceramide, galactocerebroside, glucose cerebroside, It may be sulfatide (sulfatide or sulfurized galactocerebroside), ganglioside, globoside, or mixtures thereof.

The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine (PE), phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin and cephalin. ) may include one or more materials selected from the group consisting of.

An aliphatic isocyanate monomer is mixed with a mixture of a core material and a biodegradable lipid-based material. It is preferable to mix 0.1 to 10 parts by weight of the aliphatic isocyanate monomer based on 100 parts by weight of the core material.

The aliphatic isocyanate monomer is 4,4'-dicyclohexylmethane diisocyanate, trans-1,4-cyclohexane diisocyanate, isophorone Isophorone diisocyanate, Hexamethylene diisocyanate, Trimethyl hexamethylene diisocyanate, 1,3-Bis(Isocyanomethyl)cyclohexane ), 2.4-diisocyanato cyclohexane, 1,6-diisocyanato-2,2,4-trimethylhexane, 1,6-diisocyanato-2,4,4-trimethylhexane (1,6-diisocyanato-2,4,4-trimethylhexane), 1-isocyanatomethyl-3-isocyanato-l, 5,5-trimethylcyclohexane (1-isocyanatomethyl-3-isocyanato-l,5,5-trimethyl cyclohexane), tetramethoxybutane 1,4- diisocyanate, butane 1,4- Butane 1,4-diisocyanate, hexane 1,6- diisocyanate, dicyclohexylmethane diisocyanate and cyclohexane 1,4-diisocyanate 4-diisocyanate) may include one or more materials selected from the group consisting of.

An aqueous solution of a phospholipid-based material is mixed with a mixture of a core material, a biodegradable lipid-based material, and an aliphatic isocyanate monomer, and then emulsified to form an oil/water phase emulsion. After mixing the core material, the biodegradable lipid-based material, and the aliphatic isocyanate monomer, emulsification occurs when an aqueous solution of the phospholipid-based material capable of emulsifying the core material is mixed and stirred. By the emulsification, an oil/water phase (Oil/Water, O/W or Oil in Water) emulsion (emulsion emulsion) is formed. In the emulsification process step of forming the oil/aqueous emulsion, the size of the capsule particles may be adjusted by adjusting the stirring speed and stirring time. In preparing biodegradable microcapsules, stirring speed, stirring time, etc. are adjusted in order to control the size of the capsule particles. For the stirring, a homomixer or the like may be used, and the stirring speed is preferably about 500 to 5,000 rpm, and the stirring time is about 1 minute to 1 hour, more preferably about 1 to 30 minutes. If the stirring time is too short, the size of the capsules increases, and when the biodegradable microcapsules are mixed with building materials, chemicals, etc., dispersion stability may be deteriorated, and precipitation may occur, and the effectiveness of the capsules may be reduced. If the agitation is carried out for an excessively long time, the size of the capsule becomes too small, making it difficult to collect the core material in the capsule, and the collection rate may decrease. The size of biodegradable microcapsules can be controlled by adjusting the stirring speed and stirring time, and the stability of core substances such as phase change substances, fat-soluble vitamins, functional flavors, functional oils, or mixtures thereof is increased to build biodegradable microcapsules. Dispersibility and stability can be improved when mixing materials and chemicals. If the stirring speed is increased and the stirring time is increased, small particles are formed and the stability of the core material (phase change material, fat-soluble vitamin, functional flavor, functional oil, or a mixture thereof) can be further increased.

An aqueous solution of a phospholipid-based material capable of emulsifying a core material may be an aqueous solution made by mixing 1 to 10 parts by weight of a phospholipid-based material with respect to 100 parts by weight of the core material and adding 10 to 90 parts by weight of water with respect to 100 parts by weight of the core material. there is. The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine (PE), phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin and cephalin. ) may include one or more materials selected from the group consisting of.

Heat is applied to the oil/aqueous emulsion to react while stirring to form capsules. When the oil/aqueous emulsion is reacted while stirring, biodegradable microcapsules are formed. The reaction is preferably carried out at a temperature of 40 to 90°C, more preferably 50 to 80°C, and most preferably 60 to 80°C. The stirring is preferably performed at a speed of about 100 to 1000 rpm. When the oil/aqueous emulsion is reacted, it hardens over time to form a capsule wall, and finally biodegradable microcapsules are formed. In the biodegradable microcapsule, a biodegradable lipid-based material reacts with an aliphatic isocyanate monomer to form a capsule wall, and a portion of the phospholipid-based material contained in an aqueous phospholipid-based material reacts with the aliphatic isocyanate monomer to form a capsule wall of the capsule. can achieve The strength of the capsule wall can be adjusted according to the biodegradable lipid-based material used, the aqueous solution of the phospholipid-based material used, the aliphatic isocyanate monomer used, and the mixing ratio thereof.

A protective colloidal compound is mixed with the reaction product. The protective colloidal compound includes a material having a hydroxy group or an amine group capable of reacting with the aliphatic isocyanate. Examples of such protective colloidal compounds are PEG-20 sorbitan monolaurate, PEG-20 sorbitan monopalmitate, PEG-20 sorbitan stearate, PEG-20 sorbitan monooleate, PEG-20 40 Hydrogenated Castor Oil, PEG-50 Hydrogenated Castor Oil, PEG-60 Hydrogenated Castor Oil, Polyvinyl Alcohol, Methyl Cellulose, Ethyl Cellulose, Hydroxymethyl Cellulose, Hydroxyethyl Cellulose, Hydroxypropyl Cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, dextrin, starch, polyglycerin stearate, polyglycerin laurate, polyglycerin myristate, chitosan, coconut amine, stearyl amine, sucrose stearate, or mixtures thereof; and the like.

The amount of the protective colloid compound used may vary depending on the reactivity of the biodegradable lipid-based material and the aliphatic isocyanate monomer, the aqueous solution of the phospholipid-based material, the content of the core material, etc. The protective colloid compound is based on 100 parts by weight of the core material. It is preferable to add 1 to 20 parts by weight, more preferably 1 to 10 parts by weight. The protective colloidal compound serves to prevent aggregation by suppressing adhesion between capsule walls during the process of forming the capsule walls. In addition, the protective colloidal compound completely reacts with the unreacted aliphatic isocyanate monomer so that no residual amount of the aliphatic isocyanate monomer remains. Since the protective colloid compound having a hydroxy group reacts with the aliphatic isocyanate monomer to form urethane, and the protective colloid compound having an amine group reacts with the aliphatic isocyanate monomer to form urea, unreacted aliphatic isocyanate can be completely removed.

The biodegradable microcapsules prepared in this way are preferably manufactured in a size of 0.1 to 300 μm, more preferably 1 to 300 μm. If the size is smaller, it is difficult to perform the function of the capsule smoothly and there are restrictions on mass production to secure economic feasibility. It may be difficult to do, and if it is larger than this, it is difficult to secure the stability of the capsule and there may be restrictions on application to various products.

The biodegradable microcapsule according to the present invention completely reacts the aliphatic isocyanate monomer, which may remain in trace amounts, using a reactive protective colloidal compound, thereby removing the aliphatic isocyanate monomer, which may be irritating to the human body, to ensure safety. .

The biodegradable microcapsules for functional materials manufactured in this way do not pollute the environment as they are degraded in nature after use, and are harmless to the human body such as the skin because no harmful ingredients remain in the human body. Economic feasibility and usability are improved.

In order to effectively apply phase change materials, fat-soluble vitamins, functional fragrances, or functional oils, which are the core materials of biodegradable microcapsules, to building and civil engineering materials and chemical household products, the points to be considered are phase change materials, fat-soluble vitamins, functional fragrances, Stabilization and solubilization of functional oils.

In order to solubilize phase change substances, fat-soluble vitamins, and functional oils, and to increase the stability of unstable fragrances or oils, they can be manufactured into biodegradable capsules to ensure stability and to be used as materials for chemical products. By encapsulating and stabilizing unstable fragrances or functional oils that can easily volatilize in the air or deteriorate due to oxidation, instability problems that occur when applying unstable fragrances or functional oils to chemical household products and cosmetic formulations can be improved. Efficacy can also last for a long time.

A biodegradable microcapsule having a biodegradable capsule wall is stabilized by collecting core material therein. These biodegradable microcapsules can be widely applied not only as materials for chemical products such as building and civil engineering materials, liquid detergents, and fabric softeners, but also as liquid-type cosmetic materials such as liquid-type shampoo and body soap for personal care. .

Hereinafter, experimental examples according to the present invention are specifically presented, and the present invention is not limited by the experimental examples presented below.

<Experimental Example 1>

In a 500 ml beaker, 100 g of nonadecane and 15 g of monoglycosyl ceramide (Monoglycosyl ceramide, manufactured by Avati Polar Lipid Inc.), a biodegradable lipid-based material, were evenly mixed, and 5 g of hexamethylene diisocyanate prepared in advance was added and mixed. , Phosphatidyl choline (Phosphatidyl choline, a product of Natural Factors), a phospholipid-based substance, was mixed with 10 g of water and 90 g of water, and an aqueous solution of phospholipid-based substance was added and stirred for about 20 minutes at a speed of 3,000 rpm using a homomixer to form an oil/aqueous phase. An emulsion was formed.

After adding the oil/aqueous emulsion to a 500 ml four-necked flask, adjusting the reaction temperature to 70 ° C, reacting with stirring for about 3 hours to synthesize a capsule, and then a protective colloidal compound, PEG-20 Sorbitan Monolau By adding 10 g of late, biodegradable microcapsules were finally prepared.

The average particle diameter of the biodegradable microcapsules thus obtained was 6.5 μm.

<Experimental Example 2>

Biodegradable microcapsules were prepared in the same manner as in Experimental Example 1, except that 15 g of glycolipid (RHEACE ^ⓡ One, manufactured by Evonik) was used as a biodegradable lipid-based material.

The average particle diameter of the biodegradable microcapsules thus obtained was 8.3 μm.

<Experimental Example 3>

Biodegradable microcapsules were prepared in the same manner as in Experimental Example 1, except that 15 g of glucocerebroside (Watson Co.) was used as a biodegradable lipid-based material.

The average particle diameter of the biodegradable microcapsules thus obtained was 9.7 μm.

<Experimental Example 4>

Biodegradable microcapsules were prepared in the same manner as in Experimental Example 1, except that 15 g of ganglioside (GM2, manufactured by Nagara Science Co., Ltd.) was used as a biodegradable lipid-based material.

The average particle diameter of the biodegradable microcapsules thus obtained was 5.5 μm.

Comparative examples are presented so that the characteristics of the above experimental examples can be more easily grasped, and the following comparative examples are simply presented to aid understanding and are not prior art of the present invention.

<Comparative example>

As a comparative example for the production of biodegradable microcapsules according to Experimental Examples 1 to 4, the preparation of melamine microcapsules, which are general capsules without using biodegradable materials, was performed as follows.

Add 10 g of melamine, 40 g of distilled water, 20 g of 35 wt% formaldehyde aqueous solution, and a small amount of sodium hydroxide to a 1 liter four-necked flask to adjust the pH to 8-10, and stir at 80 ° C for 30 minutes to obtain a melamine-formaldehyde prepolymer. was manufactured.

In a separate 1-liter beaker, 200 g of an emulsifier containing 5 wt% of ethylene-maleic acid copolymer resin was prepared, and 100 g of nonadecane was added thereto and stirred for about 20 minutes at a speed of 3,500 rpm using a homomixer to prepare an emulsion.

After mixing the melamine-formaldehyde prepolymer and the emulsion, they were stirred at 70° C. for 2 hours to prepare melamine microcapsules.

The average particle diameter of the melamine microcapsules thus obtained was 5.9 μm.

The microcapsules prepared according to Experimental Examples 1 to 4 and Comparative Example were evaluated for biodegradability, breakage irritation and stability.

[Method of measuring biodegradability and criteria]

KS I ISO 9408 and OECD equivalent for measuring the aerobic final biodegradability of organic compounds in a liquid medium by measuring the oxygen demand of each microcapsule prepared in Experimental Examples 1 to 4 and Comparative Example. Evaluated by the 301F method.

Specifically, it is shown in Table 1 as follows according to the measured biodegradability.

○: Biodegradability value is 60% or more compared to the reference material

△: Biodegradability value is 30% or more to less than 60% compared to the reference material

X: Biodegradability value is less than 30% compared to the standard substance

[Skin irritation test method and evaluation criteria]

Each of the microcapsules prepared in Experimental Examples 1 to 4 and Comparative Example was patched on the back of 31 subjects for 24 hours, and then observed 30 minutes, 24 hours, and 48 hours after removing the patch, and the International Contact Dermatitis Society (ICDRG) and American Cosmetics According to the criteria applied with the association (PCPC) criteria, it was evaluated as non-irritating / low-irritating / light-irritating / medium-irritating / strong-stimulating, and shown in Table 1.

[Stability test method and evaluation criteria]

After leaving each of the microcapsules prepared in Experimental Examples 1 to 4 and Comparative Example in an incubator maintained at 40 ° C., the time until the capsules do not precipitate was measured, and the time for maintaining their stability was evaluated and the table 1.

evaluation item Experimental Example 1 Experimental Example 2 Experimental Example 3 Experimental Example 4 comparative example biodegradable ○ ○ ○ ○ X skin irritation non-irritating non-irritating non-irritating hypoallergenic moderate stimulation stability more than 30 days more than 30 days more than 30 days more than 30 days less than 30 days

As shown in Table 1, Experimental Examples 1 to 4 showed excellent results in terms of biodegradability, skin irritation and stability compared to Comparative Examples.

In the above, the preferred embodiment of the present invention has been described in detail, but the present invention is not limited to the above embodiment, and various modifications are possible by those skilled in the art.

10: capsule wall
20: Oil phase of core substance

Claims (17)

A capsule having a shape in which the capsule wall surrounds the oil phase of the heart substance,
A biodegradable polymer formed by reacting a biodegradable lipid-based material with an aliphatic isocyanate monomer forms the capsule wall of the capsule,
The capsule is a biodegradable microcapsule, characterized in that having a size of 0.1 ~ 300㎛.
The method of claim 1, wherein the biodegradable lipid-based material is biodegradable, characterized in that it comprises at least one material selected from the group consisting of sphingo lipid-based material, glycolipid-based material, sphingo glycolipid-based material and phospholipid-based material. microcapsule.
The method of claim 2, wherein the sphingolipid-based material includes ceramide, phytoceramide, sphingomyelin, cerebroside, ganglioside, or a mixture thereof,
The glycolipid-based material includes glycerol glycolipids, galatolipids, sulfolipids, or mixtures thereof,
The sphingo glycolipid-based substance is glycolipid, cerebroside, glucocerebroside, monoglycosylceramide, galactocerebroside, glucose cerebroside, Contains sulfatide (sulfatide or sulfurized galactocerebroside), ganglioside, globoside or mixtures thereof;
The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin, cephalin or Biodegradable microcapsules comprising a mixture thereof.
The method of claim 1, wherein the aliphatic isocyanate monomer is 4,4'-dicyclohexylmethane diisocyanate, trans-1,4-cyclohexane diisocyanate (trans-1,4- Cyclohexane diisocyanate, Isophorone diisocyanate, Hexamethylene diisocyanate, Trimethyl hexamethylene diisocyanate, 1,3-bis(isocyanomethyl)cyclohexane (1,3 -Bis (Isocyanomethyl) cyclohexane), 2.4-diisocyanato cyclohexane, 1,6-diisocyanato-2,2,4-trimethylhexane (1,6-diisocyanato-2,2 ,4-trimethylhexane), 1,6-diisocyanato-2,4,4-trimethylhexane (1,6-diisocyanato-2,4,4-trimethylhexane), 1-isocyanatomethyl-3-iso 1-isocyanatomethyl-3-isocyanato-l,5,5-trimethyl cyclohexane, tetramethoxybutane 1,4- diisocyanate , butane 1,4-diisocyanate, hexane 1,6- diisocyanate, dicyclohexylmethane diisocyanate and cyclohexane 1,4- A biodegradable microcapsule comprising at least one material selected from the group consisting of cyclohexane 1,4-diisocyanate.
The method of claim 1, wherein the core material is at least one phase change material selected from the group consisting of nonadecane, octadecane, heptadecane, hexadecane, tetradecane, pentadecanestearic acid, cyanamide, propyl amide, and pentaerythritol. Biodegradable microcapsules comprising a.
The method of claim 1, wherein the heart substance is 1 selected from the group consisting of α-carotene, β-carotene, retinol, tretinoin, alphacalcidol, dihydrotachisterol, calcipotriol, tocopherol, naphthoquinone, and phylloquinone. Biodegradable microcapsules, characterized in that they contain more than one kind of fat-soluble vitamins.
The biodegradable microcapsule according to claim 1, wherein the core material includes phase change material (PCM), fat-soluble vitamins, functional flavors, functional oils, or mixtures thereof.
A method for producing a capsule having a shape in which the capsule wall surrounds the oil phase of the core substance,
mixing a core material, a biodegradable lipid-based material, and an aliphatic isocyanate monomer;
Mixing and emulsifying an aqueous solution of a phospholipid-based material capable of emulsifying the core material with a mixture of a core material, a biodegradable lipid-based material, and an aliphatic isocyanate monomer to form an oil/water phase emulsion;
Applying heat to the oil/aqueous emulsion to react while stirring to form capsules; and
Mixing a protective colloidal compound with the reaction product,
A biodegradable polymer formed by reacting a biodegradable lipid-based material with an aliphatic isocyanate monomer forms the capsule wall of the capsule,
The method of producing a biodegradable microcapsule, characterized in that the capsule has a size of 0.1 ~ 300㎛.
The method of claim 8, wherein the biodegradable lipid-based material is biodegradable, characterized in that it comprises at least one material selected from the group consisting of sphingo lipid-based material, glycolipid-based material, sphingo glycolipid-based material and phospholipid-based material Manufacturing method of microcapsules.
10. The method of claim 9, wherein the sphingolipid-based material includes ceramide, phytoceramide, sphingomyelin, cerebroside, ganglioside, or a mixture thereof,
The glycolipid-based material includes glycerol glycolipids, galatolipids, sulfolipids, or mixtures thereof,
The sphingo glycolipid-based substance is glycolipid, cerebroside, glucocerebroside, monoglycosylceramide, galactocerebroside, glucose cerebroside, Contains sulfatide (sulfatide or sulfurized galactocerebroside), ganglioside, globoside or mixtures thereof;
The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin, cephalin or A method for producing biodegradable microcapsules comprising a mixture thereof.
The method of claim 8, wherein the aliphatic isocyanate monomer is 4,4'-dicyclohexylmethane diisocyanate, trans-1,4-cyclohexane diisocyanate (trans-1,4- Cyclohexane diisocyanate, Isophorone diisocyanate, Hexamethylene diisocyanate, Trimethyl hexamethylene diisocyanate, 1,3-bis(isocyanomethyl)cyclohexane (1,3 -Bis (Isocyanomethyl) cyclohexane), 2.4-diisocyanato cyclohexane, 1,6-diisocyanato-2,2,4-trimethylhexane (1,6-diisocyanato-2,2 ,4-trimethylhexane), 1,6-diisocyanato-2,4,4-trimethylhexane (1,6-diisocyanato-2,4,4-trimethylhexane), 1-isocyanatomethyl-3-iso 1-isocyanatomethyl-3-isocyanato-l,5,5-trimethyl cyclohexane, tetramethoxybutane 1,4- diisocyanate , butane 1,4-diisocyanate, hexane 1,6- diisocyanate, dicyclohexylmethane diisocyanate and cyclohexane 1,4- A method for producing biodegradable microcapsules comprising at least one material selected from the group consisting of diisocyanate (cyclohexane 1,4-diisocyanate).
The method of claim 8, wherein the biodegradable lipid-based material is mixed with 1 to 20 parts by weight based on 100 parts by weight of the core material,
The aliphatic isocyanate monomer is a method for producing biodegradable microcapsules, characterized in that 0.1 to 10 parts by weight is mixed with respect to 100 parts by weight of the core material.
The method of claim 8, wherein the aqueous solution of the phospholipid-based material is an aqueous solution prepared by mixing 1 to 10 parts by weight of the phospholipid-based material with respect to 100 parts by weight of the core material and adding 10 to 90 parts by weight of water with respect to 100 parts by weight of the core material,
The phospholipid-based material is phosphatidyl choline, phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, diphosphatidylglycerol, lecithin and cephalin. A method for producing biodegradable microcapsules comprising at least one material selected from the group consisting of:
9. The method of claim 8, wherein the protective colloidal compound comprises a material having a hydroxy group or an amine group capable of reacting with the aliphatic isocyanate monomer.
The method of claim 8, wherein the core material is at least one phase change material selected from the group consisting of nonadecane, octadecane, heptadecane, hexadecane, tetradecane, pentadecanestearic acid, cyanamide, propyl amide and pentaerythritol Method for producing biodegradable microcapsules comprising a.
The method of claim 8, wherein the heart substance is α-carotene, β-carotene, retinol, tretinoin, alphacalcidol, dihydrotachisterol, calcipotriol, tocopherol, naphthoquinone and phylloquinone selected from the group consisting of 1 A method for producing biodegradable microcapsules comprising at least one fat-soluble vitamin.
The method of claim 8, wherein the core material includes a phase change material (PCM), a fat-soluble vitamin, a functional flavor, a functional oil, or a mixture thereof.

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