KR101346844B1 - microsphere containing water soluble active materials and fat soluble active materials by multiple emulsion, and cosmetic composition comprising the microsphere - Google Patents

Abstract

The present invention relates to microspheres of spherical particles comprising a water-soluble active substance and a fat-soluble active substance used in cosmetics at the same time through a multi-emulsion of w1 / o / w2 form, specifically, a water-soluble active substance micro Located at the innermost side of the sphere, the organic layer surrounding the water-soluble active material contains a fat-soluble active material and a hydrophobic polymer together, and the outermost part is composed of a water phase, containing both a water-soluble active material and a fat-soluble active material at the same time A microsphere and a cosmetic composition containing the same.
Microspheres according to the present invention by containing a water-soluble active material and a fat-soluble active material that is an active material in cosmetics in a single microsphere through a multi-emulsion, conventionally a water-soluble active material and a fat-soluble active material as a core material The multi-step process of preparing the microcapsules and mixing them together can be simplified into a single process, and the titer of the active substance is influenced by external factors such as heat, light, air, moisture, and metal ions during storage. The fall of a cosmetic is suppressed and stability of cosmetics is improved.

Description

Microsphere containing water soluble active materials and fat soluble active materials by multiple emulsion, and cosmetic composition comprising the microsphere

The present invention relates to microspheres of spherical particles comprising a water-soluble active substance and a fat-soluble active substance used in cosmetics at the same time through a multi-emulsion of w1 / o / w2 form, specifically, a water-soluble active substance micro Located at the innermost side of the sphere, the organic layer surrounding the water-soluble active material contains a fat-soluble active material and a hydrophobic polymer together, and the outermost part is composed of a water phase, containing both a water-soluble active material and a fat-soluble active material at the same time A microsphere and a cosmetic composition containing the same.

Functional cosmetics refers to cosmetics that have improved efficacy and safety, that is, products with enhanced functionality, which can be classified into wrinkle-improving, whitening, and ultraviolet screening products and existing between both groups of pharmaceuticals and cosmetics.

Substances that are active in functional cosmetics can be classified into water-soluble active substances or fat-soluble active substances, and are prone to unstable conditions by external factors such as temperature, pH, light, and air. Stabilization of heavy functional active materials is required.

Accordingly, various materials and manufacturing methods have been proposed to increase the physical and chemical stability of functional active materials, for example, nanocapsule, microsphere, liposome, niosome, etc. Various methods are introduced.

Among them, microspheres protect active ingredients or unstable substances from external stress to control the release rate of internal active ingredients, and in particular, prevent cosmetics from lowering the titer of functional cosmetic raw materials due to high temperature, humidity and microbial contamination. Indicates.

The material carried inside the microspheres is called a core material and the outer coating material is called a wall. The core material is made up of various active ingredients inside the wall and encapsulated and used in various fields such as cosmetics, medicines and foods. have.

For example, vitamin C, which is widely used in cosmetics, is a representative water-soluble vitamin, and when applied to skin, collagen synthesis, anti-aging effect, and wrinkle improvement effect are known to be excellent, but heat, light, air, metal ions, etc. There is a lot of problems to use as a functional cosmetic raw material because the color change and odor generated by oxidation.

In order to solve this problem, polymethylmethacrylate particles having various micron sizes are prepared by emulsion polymerization, and the coating solution (water and ethanol mixed solvent is prepared on the surface of the prepared polymethylmethacrylate particles). A method of coating vitamin C using cyclodextrin and a solution of vitamin C) has been proposed (Analytical Science & Technology, Vol 19, No 6, 468-472, 2006).

However, since the water-soluble active substance vitamin C is not contained in the capsule and coated on the surface of the hydrophobic polymer polymethyl methacrylate, it is included in the cosmetics, and thus there is a problem that it is easy to react with other ingredients and is exposed to heat and air.

In addition, vitamin A (retinol), a representative fat-soluble vitamin used in cosmetics, is a functional ingredient that helps to improve wrinkles of the skin, and vitamin A and its derivatives are collectively called retinoids.

However, retinoids are also easily oxidized in an aqueous solution or air, causing a problem in that the titer decreases and discoloration occurs over time. Thus, research has been conducted to increase the stability by preparing them as capsules.

For example, Korean Patent Publication No. 0173445 discloses an unstable cosmetic fat-soluble active substance retinoid (retinol, retinic acid, retinaldehyde and derivatives), tocopherol, unsaturated fatty acid and its derivatives, fat-soluble pigment or vitamin F, etc. The invention relates to a cosmetic double capsule and a cosmetic composition containing the same, which are prepared by dispersing and crosslinking by adding a crosslinking agent to prepare a primary capsule and then adding it to an aqueous solution of gellan gum at an appropriate concentration and adding other additives into a double capsule. .

As described above, the conventional microcapsule manufacturing method has prepared a microcapsule containing a water-soluble active material by coating a water-soluble active material on the surface of the hydrophobic polymer or by dissolving the water-soluble polymer with a water-soluble active material and then putting it in a poorly soluble solution. In addition, after mixing the hydrophobic polymer and the fat-soluble active material in the organic solvent together, a microcapsule containing the fat-soluble active material was prepared by solvent evaporation.

As such, in order to use the water-soluble active substance and the fat-soluble active substance together in the cosmetics, the microcapsules containing the water-soluble active substance and the microcapsules containing the fat-soluble active ingredient are prepared, respectively, and mixed with the cosmetics.

The present invention reduces the titer of the active substance by external factors such as heat, light, air, moisture, and metal ions, while containing water-soluble active substance and fat-soluble active substance which are active substances in cosmetics together in one microsphere. It is to provide a method that can be prevented to ensure the stability of the cosmetic.

In order to solve the above problems, the present invention surrounds the inner layer (w1) in which the water-soluble active substance is dissolved in purified water, the inner layer, and the organic layer (o) in which the fat-soluble active substance and the hydrophobic polymer are dissolved in the organic solvent, and the organic layer. The emulsion stabilizer comprises an outer layer (w2) dissolved in purified water, wherein the inner layer (w1) is 0.1-20.0 wt% of the sum of the inner layer (w1) and the organic layer (o), and the sum of the inner layer (w1) and the organic layer (o) is 10-50% by weight of the sum of the inner layer (w1), the organic layer (o) and the outer layer (w2), and the hydrophobic polymer is at least one selected from the group consisting of polymethyl methacrylate and polylactic acid, and has a water-soluble active substance and a fat-soluble composition. The water-soluble active substance and the fat-soluble active substance by multi-emulsion are characterized in that the water-soluble active substance and the fat-soluble active substance are accommodated inside with a weight of 10-100 times the sum of the active substance weight. It provides microspheres contained.

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The present invention also provides a cosmetic composition containing the microspheres.

Microspheres according to the present invention by containing a water-soluble active material and a fat-soluble active material that is an active material in cosmetics in a single microsphere through a multi-emulsion, conventionally a water-soluble active material and a fat-soluble active material as a core material Several steps of preparing the containing microcapsules and then mixing and using the same may be simplified into one process.

In addition, the stability of the cosmetics is improved by suppressing the lowering of the titer of the active substance by external factors such as heat, light, air, moisture, and metal ions during storage.

1 is a view showing the potency retention of vitamins A (retinol) and vitamin C (ascorbic acid) of the microspheres prepared in Examples 1 and 4 of the present invention.
Figure 2 is a view showing the potency retention of epigallocatechin gallate (epigallocatechin gallate, EGCG) and vitamin E (tocopherol) of the microspheres prepared in Examples 2 and 5.
Figure 3 is a view showing the potency retention of folic acid (folic acid) and vitamin K1 (phylloquinone) of the microspheres prepared in Examples 3 and 6.
Figure 4 is a view showing the potency maintenance of the cosmetic containing the microspheres of Application Examples 1 to 6 according to the present invention.
5 is a view showing a micrograph of the microspheres containing vitamin A and vitamin C prepared in Example 1.
FIG. 6 is a micrograph showing microspheres containing epicalocatechin gallate and vitamin E prepared in Example 2. FIG.
7 is a view showing a micrograph of the microspheres containing folic acid and vitamin K1 prepared in Example 3.
8 is a view showing a micrograph of the microspheres containing vitamin A and vitamin C prepared in Example 4.
FIG. 9 is a micrograph showing microspheres containing epicalocatechin gallate and vitamin E prepared in Example 5. FIG.
10 is a view showing a micrograph of the microspheres containing folic acid and vitamin K1 prepared in Example 6.

The present invention relates to a microsphere that simultaneously accommodates the water-soluble active substance and the fat-soluble active substance used in cosmetics in the capsule through the multiple emulsions of w1 / o / w2, a preparation method thereof and a cosmetic composition containing the same, The microsphere of the present invention has an inner layer (w1) in which a water-soluble active substance is dissolved in purified water, an inner layer, and an organic layer (o) in which an oil-soluble active substance and a hydrophobic polymer are dissolved in an organic solvent, and the organic layer, and an emulsifying stabilizer in the purified water. It consists of the melted outer layer (w2).

In addition, the method for producing microspheres of the present invention comprises the steps of preparing an internal aqueous phase by dissolving a water-soluble active material in purified water, preparing an organic material by dissolving a fat-soluble active material and a hydrophobic polymer in an organic solvent, the internal aqueous material Mixing with the organic material to perform a primary emulsification to prepare a primary emulsion in the form of w1 / o, dissolving an emulsifier stabilizer in purified water to prepare an external aqueous phase, and subjecting the primary emulsion to the external aqueous phase After mixing with the material to perform a second emulsification to prepare a secondary emulsion of the w1 / o / w2 form and to remove the organic solvent by distillation of the secondary emulsion under reduced pressure.

The water-soluble active substance is a water-soluble substance exhibiting activity on the skin such as wrinkle improvement, whitening, and ultraviolet rays while being used as an external skin agent, and is stably lowered by being influenced by external factors such as heat, light, air, moisture, and metal ions. Vitamin B and its derivatives, Vitamin C and its derivatives, epicalocatechin gallate, water soluble plant extracts, water soluble flavors, enzymes, microbial extracts, minerals and the like.

A water-soluble active substance is dissolved in purified water to prepare an internal water phase material, and the water-soluble active material is suitably contained in an amount of 0.01 to 30% by weight of the internal water phase material.

The fat-soluble active substance is also used as an external preparation for skin, but vitamin A and its derivatives, vitamin D and its derivatives, vitamin E and its derivatives, vitamin F and its, which are affected by heat, light, air, moisture, metal ions, etc. Derivatives, vitamin K and its derivatives, organic ultraviolet blockers, fat soluble plant extracts, fat soluble flavors and the like.

The fat-soluble active substance is dissolved in an organic solvent to prepare an organic substance, and the fat-soluble active substance is suitably contained in an amount of 0.1 to 10.0% by weight of the organic substance.

In order to place the water-soluble active substance and the fat-soluble active substance inside the wall, the organic solvent is mixed with a hydrophobic polymer having a water weight of 10 to 100 times the sum of the weight of the water-soluble active substance and the fat-soluble active substance.

The hydrophobic polymer may be selected from polymethyl methacrylate and polylactic acid, and may be used alone or in combination of two.

In addition, an antioxidant may be further added to the organic material. The antioxidant is not toxic to the skin while being soluble in an organic solvent and is not restricted to use. For example, dibutylhydroxytoluene ( dibutyl hydroxytoluene (BHT) can be used, and it is suitable to contain 0.05 to 0.2% by weight of the organic material.

In particular, the use of vitamin C as a water-soluble active substance has the effect of increasing the antioxidant capacity by interacting with dibutylhydroxytoluene, has a favorable effect on the stability of the microsphere of the present invention.

Next, the primary aqueous phase (w1 / o) is prepared by mixing the internal aqueous phase material and the organic material. The internal aqueous phase material is added to the organic material without using a surfactant and mixed with a homomixer, followed by a high pressure homogenizer. (microfluidizer) is used to prepare a primary emulsion (w1 / o) that forms spherical particles of micro size, for example 0.1-2.0 μm in diameter.

The spherical particles of the primary emulsion form a water in oil (w / o) which surrounds the inner layer (w1) of the water phase with the organic layer (o) of the oil phase, wherein the inner layer (w1) is 1 It is contained at 0.1 to 20.0% by weight of the tea emulsion (w1 / o).

Next, it is preferable to dissolve an emulsion stabilizer (emulsion stabilizer) in purified water to prepare an external water phase material, the emulsion stabilizer is preferably contained in 0.1 to 1.0% by weight of the external water phase material, HLB (hydrophilic) as the emulsion stabilizer Lipophilic balance 8 to 15 polyvinyl alcohol (o / w) surfactants (polyvinyl alcohol) may be used.

The external aqueous phase material is mixed with the prepared primary emulsion (w1 / o) and a secondary emulsion ((w1 / o / w2) is prepared using a homomixer, and then distilled under reduced pressure to obtain an organic layer (o). By removing the organic solvent, a microsphere containing both a water-soluble active substance and a fat-soluble active substance is prepared.

The primary emulsion (w1 / o) is preferably contained 10 to 50% by weight of the secondary emulsion (w1 / o / w2), the prepared microspheres are formed in a sphere having a size of 1 ~ 100㎛ diameter do.

The microspheres prepared according to the present invention contain both a water-soluble active substance and a fat-soluble active substance, and the titer of the active substance is not lowered by external factors such as heat, light, air, moisture, and metal ions. Nourishing lotion, massage cream, nourishing cream, pack, gel, skin type cosmetic, lipstick, makeup base, foundation, shampoo, rinse, body cleanser, soap, toothpaste, mouthwash, lotion, ointment, gel, cream, patch or It can be applied without limitation to various formulations such as sprays.

Hereinafter, the present invention will be described in more detail based on the following Examples, Application Examples, and Test Examples.

It is to be understood, however, that the invention is not to be construed as limited to the embodiments set forth herein, but is capable of modifications and equivalents within the spirit and scope of the invention. Will be apparent to those skilled in the art to which the present invention pertains.

Example 1 Preparation of Microspheres Containing Vitamin A and Vitamin C

0.2 g of vitamin C was dissolved in 7.5 g of purified water at 40 ° C to prepare an aqueous part (w1).

An oil phase part (o) was prepared by dissolving 10 g of polylactic acid (average molecular weight 100000), 0.1 g of dibutylhydroxytoluene and 0.4 g of vitamin A in 80 g of methylene chloride.

The aqueous part (w1) was slowly added to the oil phase part (o) while maintaining the temperature at 20 ° C. and emulsified at 5000 rpm for 3 minutes with a homomixer, and then twice at 700 bar using a high pressure homogenizer (M-110F, Microfluidics, USA). By circulation, a primary emulsion (w1 / o) was prepared.

The primary emulsion (w1 / o) was slowly added to 200 g of the aqueous part (w2) containing 0.3% by weight of polyvinyl alcohol while emulsifying at 5000 rpm for 3 minutes using a homomixer to prepare the secondary emulsion (w1 / o / w2). Prepared.

The secondary emulsion, which had been emulsified, was distilled under reduced pressure while heating to 50 ° C. to remove methylene chloride, and filtered and dried under reduced pressure for 12 hours at 45 ° C. to prepare microspheres containing both vitamin A and vitamin C (yield: 81.4). %).

The presence of microspheres was confirmed by 1000 times magnification observation with a microscope (NSB-50T, Samwon Science Industry Co., Ltd., Korea) (Software: Imagepartner ™) (see FIG. 5).

Example 2 Preparation of Microspheres Containing Epigallocategin Gallate and Vitamin E

In Example 1, instead of the aqueous solution of vitamin C as the aqueous part (w1), 0.5g of epigallocategin gallate was added to 9.5g of purified water adjusted to pH 3.0 by adding lactic acid to purified water. The microspheres containing both epigallocategin gallate and vitamin E were prepared in the same manner as in Example 1, except that 0.4 g of vitamin E was used instead of vitamin A as an oil phase part (o). Prepared (yield: 83.8%).

1000 times magnification was observed under the microscope to confirm the presence of microspheres (see FIG. 6).

Example 3 Preparation of Microspheres Containing Folic Acid and Vitamin K1

In Example 1, 0.01 g of folic acid was used instead of vitamin C as the water part (w1), and 0.4 g of vitamin K1 was used instead of vitamin A as the oil phase part (o). By the method, microspheres containing both folic acid and vitamin K1 were prepared (yield: 80.5%).

1000 times magnification was observed with the microscope to confirm the presence of microspheres (see FIG. 7).

Example 4 Preparation of Microspheres Containing Vitamin A and Vitamin C

In Example 1, except that 10g of polymethyl methacrylate was used in place of the polylactic acid of the oil phase part (o), a microsphere containing both vitamin A and vitamin C was prepared in the same manner as in Example 1. Yield: 88.3%.

The microscope was observed at 1000 times magnification to confirm the presence of microspheres (see FIG. 8).

Example 5 Preparation of Microspheres Containing Epigallocategin Gallate and Vitamin E

In Example 2, except that 10 g of polymethyl methacrylate was used instead of the polylactic acid of the oil phase part (o), both epigallocategin gallate and vitamin E were contained in the same manner as in Example 2. Microspheres were prepared (yield: 85.9%).

The microscope was observed at 1000 times magnification to confirm the presence of microspheres (see FIG. 9).

Example 6 Preparation of Microspheres Containing Folic Acid and Vitamin K1

In Example 3, except that 10 g of polymethyl methacrylate was used instead of the polylactic acid of the oil phase part (o), a microsphere containing both folic acid and vitamin K1 was prepared in the same manner as in Example 3. (Yield 87.1%).

The microscope was observed at 1000 times magnification to confirm the presence of microspheres (see FIG. 10).

<Application Examples 1 to 6> Preparation of Cosmetic Composition

The microspheres prepared in Examples 1 to 6 were added to prepare a cosmetic composition with the composition of Table 1 below.

Composition (% by weight) Application example 1 Application example 2 Application Example 3 Application example 4 Application Example 5 Application Example 6 Microspheres (Example 1) 3.00 - - - - - Microspheres (Example 2) - 3.00 - - - - Microspheres (Example 3) - - 3.00 - - - Microspheres (Example 4) - - - 3.00 - - Microspheres (Example 5) - - - - 3.00 - Microspheres (Example 6) - - - - - 3.00 glycerin 1.00 1.00 1.00 1.00 1.00 1.00 Butylene glycol 2.00 2.00 2.00 2.00 2.00 2.00 Arakidil Alcohol / Behenyl Alcohol / Arachidyl Glucoside 2.50 2.50 2.50 2.50 2.50 2.50 Glyceryl stearate 0.50 0.50 0.50 0.50 0.50 0.50 FAGE-4 olivate 0.50 0.50 0.50 0.50 0.50 0.50 Caprylic / capric triglyceride 5.00 4.00 5.00 5.00 4.00 5.00 Cholesteryl / behenyl / octyldodecyllaurylglutamate 1.00 1.00 1.00 1.00 1.00 1.00 Macadamia Seed Oil 1.00 1.00 1.00 1.00 1.00 1.00 Dimethicone 0.50 0.50 0.50 0.50 0.50 0.50 Cyclopentasiloxane / cyclohexasiloxane 2.00 2.00 2.00 2.00 2.00 2.00 Cetearyl alcohol 1.00 1.00 1.00 1.00 1.00 1.00 Mineral oil 2.50 2.50 2.50 2.50 2.50 2.50 Disodium iodide 0.03 0.03 0.03 0.03 0.03 0.03 BH 0.05 0.05 0.05 0.05 0.05 0.05 Tocopheryl acetate 0.30 0.30 0.30 0.30 0.30 0.30 Panthenol 0.20 0.20 0.20 0.20 0.20 0.20 Ethyl hexylmethoxycinnamate 0.20 0.20 0.20 0.20 0.20 0.20 Propylparaben 0.10 0.10 0.10 0.10 0.10 0.10 Methyl paraben 0.20 0.20 0.20 0.20 0.20 0.20 incense 0.01 0.01 0.01 0.01 0.01 0.01 Purified water to 100 to 100 to 100 to 100 to 100 to 100

&Lt; Test Example 1 >

The titer of the microspheres prepared in Examples 1 to 6 and the cosmetic composition containing the microspheres of Application Examples 1 to 6 was measured to determine the stability of the water-soluble active substance and the fat-soluble active substance.

Measurements were carried out at 1 week intervals for 4 weeks at a high temperature of 45 ℃ using HPLC (High Performance Liquid Chromatography) to confirm the high temperature stability by the multiple emulsion (w1 / o / w2) stabilization system.

1 shows the titer of the microspheres prepared in Examples 1 and 4 of vitamin A and vitamin C, and Fig. 2 shows epigallocategin gallate and the microspheres prepared in Examples 2 and 5. The titer of vitamin E is shown, and FIG. 3 shows the titer of folate and vitamin K1 of the microspheres prepared in Examples 3 and 6.

As can be seen in Figures 1 to 3, the change in the titer according to the polylactic acid and polymethyl methacrylate as a water-soluble active material and fat-soluble active material as the active material, a hydrophobic polymer did not show a constant tendency, but at a high temperature of 45 ℃ It can be seen that the stability is maintained more than 85% when exposed for 4 weeks at.

In addition, Figure 4 shows the potency maintenance capacity of the cosmetic composition containing the multiple microspheres of the application examples 1 to 6, the folic acid and vitamin K1 is contained as an active material and polymethyl methacrylate is used as a hydrophobic polymer The stability of Application Example 6 containing the microspheres of 6 was the best.

On the other hand, the stability of Application Example 3 containing the microspheres of Example 3 containing folic acid and vitamin K1 as the active substance and polylactic acid as the hydrophobic polymer was measured to be the lowest, but remained stable after 1 week. It became.

Overall, when the cosmetics are exposed for 4 weeks at a high temperature of 45 ℃ it can be seen that the stability of the active material is maintained at 90% or more, the active material exhibiting activity in the functional cosmetics multi-emulsion according to the present invention (w1 / o / w2) It can be seen that the inclusion in the microspheres in such a way has an effect on the stability of the active material.

<Test Example 2> Discoloration experiment

The cosmetic composition prepared according to Application Examples 1 to 6 was stored for 4 weeks at a temperature of 25 ° C. and 45 ° C. to observe whether the formulation was discolored and the results are shown in Table 2 below.

Condition Early 1 week 2 weeks 3 weeks 4 weeks Application example 1 25 ℃ - - - - - 45 ° C - - - - - Application example 2 25 ℃ - - - - - 45 ° C - - - - ± Application Example 3 25 ℃ - - - - - 45 ° C - - - - - Application example 4 25 ℃ - - - - - 45 ° C - - - ± + Application Example 5 25 ℃ - - - - - 45 ° C - - - - ± Application Example 6 25 ℃ - - - - - 45 ° C - - - - -

(-: No discoloration, ±: slight discoloration, +: discoloration)

As shown in Table 2, no discoloration was observed at a temperature of 25 ° C, and discoloration began to appear in Application Example 4 after 3 weeks and Application Examples 2 and 5 after 4 weeks at a temperature of 45 ° C. .

That is, discoloration did not occur until after 4 weeks at room temperature, and discoloration occurred after 3 weeks when heated to high temperature. It is judged that it would be desirable to prepare cosmetics in the formulations of Examples 1, 3 and 6.

As described above, the microspheres according to the present invention can accommodate microcapsules each containing a conventional water-soluble active substance and a fat-soluble active substance as a core substance in a single microsphere through a multiple emulsion stabilization system, and also storage. There is an effect that the stability of the cosmetic is improved by suppressing the lowering of the titer of the active substance by external factors such as heavy heat, light, air, moisture, and metal ions.

w1: inner layer of water-soluble active substance dissolved in purified water,
w2: an outer layer in which an emulsifying stabilizer is dissolved in purified water,
o: organic layer in which a fat-soluble active ingredient and a hydrophobic polymer are dissolved in an organic solvent

Claims (17)

Inner layer (w1) in which a water-soluble active substance is dissolved in purified water,
An organic layer (o) surrounding the inner layer and in which an oil-soluble active material and a hydrophobic polymer are dissolved in an organic solvent;
Surrounding the organic layer and the emulsion stabilizer comprises an outer layer (w2) dissolved in purified water,
The inner layer w1 is 0.1-20.0% by weight of the sum of the inner layer w1 and the organic layer o, and the sum of the inner layer w1 and the organic layer o is the sum of the inner layer w1, the organic layer o, and the outer layer w2. 10-50% by weight,
The hydrophobic polymer is at least one selected from the group consisting of polymethyl methacrylate and polylactic acid, and the water-soluble active substance and the fat-soluble active substance have a weight of 10 to 100 times the sum of the weight of the water-soluble active substance and the fat-soluble active substance. A microsphere containing water-soluble active substance and a fat-soluble active substance by multiple emulsions together. The method according to claim 1,
The water-soluble active substance is at least one selected from the group consisting of vitamin B and its derivatives, vitamin C and its derivatives, epicalocatechin gallate, water-soluble plant extracts, water-soluble flavors, enzymes, microbial extracts and minerals,
The fat-soluble active substance is selected from the group consisting of vitamin A and its derivatives, vitamin D and its derivatives, vitamin E and its derivatives, vitamin F and its derivatives, vitamin K and its derivatives, organic ultraviolet blockers, fat-soluble plant extracts and fat-soluble flavors. At least one of which is characterized in that, the microsphere containing a water-soluble active material and a fat-soluble active material by multiple emulsions together. The method according to claim 1,
The water-soluble active material is characterized in that it contains 0.01 to 30% by weight of the inner layer (w1), microspheres containing both the water-soluble active material and the fat-soluble active material by a multi-emulsion. The method according to claim 1,
The fat-soluble active material is characterized in that it contains 0.1 to 10.0% by weight of the organic layer (o), microspheres containing both a water-soluble active material and a fat-soluble active material by a multi-emulsion. delete delete The method according to claim 1,
The organic layer (o) is a microsphere containing a water-soluble active material and a fat-soluble active material by multiple emulsions, characterized in that further comprises 0.05 to 0.2% by weight of dibutyl hydroxytoluene. delete The method according to claim 1,
The organic layer (o) is a microsphere containing a water-soluble active material and a fat-soluble active material by a multi-emulsion, characterized in that the spherical particles of 0.1 ~ 2.0㎛ diameter. The method according to claim 1,
The emulsion stabilizer is a microsphere containing water-soluble active material and fat-soluble active material by a multi-emulsion, characterized in that contained in 0.1 to 1.0% by weight of the outer layer (w2). The method according to claim 1,
The emulsifying stabilizer is a microsphere of HLB 8 ~ 15, characterized in that the microspheres containing a water-soluble active material and a fat-soluble active material by a multi-emulsion. delete The method according to claim 1,
The microspheres are spherical particles having a size of 1 ~ 100㎛ diameter, microspheres containing a water-soluble active material and a fat-soluble active material by a multi-emulsion. delete delete Cosmetic composition containing the microsphere of any one of Claims 1-4, Claim 7, 9-11, or 13. 18. The method of claim 16,
The cosmetic composition is a flexible cosmetics, nourishing cosmetics, massage cream, nourishing cream, pack, gel, skin adhesive type cosmetics, lipstick, makeup base, foundation, lotion, ointment, gel, cream, patch or spray Composition.

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