KR20230052930A - Tlr9의 억제제로서 유용한 치환된 헤테로아릴 화합물 - Google Patents
Tlr9의 억제제로서 유용한 치환된 헤테로아릴 화합물 Download PDFInfo
- Publication number
- KR20230052930A KR20230052930A KR1020237009018A KR20237009018A KR20230052930A KR 20230052930 A KR20230052930 A KR 20230052930A KR 1020237009018 A KR1020237009018 A KR 1020237009018A KR 20237009018 A KR20237009018 A KR 20237009018A KR 20230052930 A KR20230052930 A KR 20230052930A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- methyl
- pyrrolo
- pyridine
- methylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063067389P | 2020-08-19 | 2020-08-19 | |
| US63/067,389 | 2020-08-19 | ||
| PCT/US2021/046475 WO2022040293A1 (en) | 2020-08-19 | 2021-08-18 | Substituted heteroaryl compounds useful as inhibitors of tlr9 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230052930A true KR20230052930A (ko) | 2023-04-20 |
Family
ID=77726550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237009018A Pending KR20230052930A (ko) | 2020-08-19 | 2021-08-18 | Tlr9의 억제제로서 유용한 치환된 헤테로아릴 화합물 |
Country Status (17)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4267560A1 (en) * | 2020-12-22 | 2023-11-01 | Gilead Sciences, Inc. | 6-substituted indole compounds |
| EP4267559A1 (en) * | 2020-12-22 | 2023-11-01 | Gilead Sciences, Inc. | Substituted indole compounds |
| US11661431B2 (en) | 2021-04-16 | 2023-05-30 | Gilead Sciences, Inc. | Thienopyrrole compounds |
| TW202440078A (zh) | 2021-09-10 | 2024-10-16 | 美商基利科學股份有限公司 | 噻吩并吡咯化合物 |
| MX2024009441A (es) * | 2022-02-18 | 2024-08-14 | Bristol Myers Squibb Co | Compuestos de imidazopiridinilo sustituidos utiles como inhibidores del receptor tipo toll 9 (tlr9). |
| WO2024102886A1 (en) * | 2022-11-10 | 2024-05-16 | Bristol-Myers Squibb Company | Substituted benzimidazole compounds useful as inhibitors of tlr9 |
| CN120152957A (zh) * | 2022-11-10 | 2025-06-13 | 百时美施贵宝公司 | 用作tlr9抑制剂的经取代的喹诺酮 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130158049A1 (en) * | 2011-12-20 | 2013-06-20 | Hoffmann-La Roche Inc. | 7-azaindole inhibitors of crac |
| US9643967B2 (en) | 2013-12-13 | 2017-05-09 | Takeda Pharmaceutical Company Limited | Pyrrolo[3,2-c]pyridine derivatives as TLR inhibitors |
| AR103232A1 (es) * | 2014-12-22 | 2017-04-26 | Bristol Myers Squibb Co | ANTAGONISTAS DE TGFbR |
| MX2020006168A (es) * | 2017-12-18 | 2020-08-13 | Bristol Myers Squibb Co | Compuestos de 4-azaindol. |
| EP3728253B1 (en) * | 2017-12-19 | 2024-03-27 | Bristol-Myers Squibb Company | 6-azaindole compounds |
| KR102730859B1 (ko) * | 2017-12-20 | 2024-11-15 | 브리스톨-마이어스 스큅 컴퍼니 | 아릴 및 헤테로아릴 치환된 인돌 화합물 |
-
2021
- 2021-08-18 EP EP21769573.3A patent/EP4200015B1/en active Active
- 2021-08-18 US US18/042,018 patent/US20230322770A1/en active Pending
- 2021-08-18 KR KR1020237009018A patent/KR20230052930A/ko active Pending
- 2021-08-18 WO PCT/US2021/046475 patent/WO2022040293A1/en not_active Ceased
- 2021-08-18 ES ES21769573T patent/ES3070309T3/es active Active
- 2021-08-18 MX MX2023001883A patent/MX2023001883A/es unknown
- 2021-08-18 JP JP2023512161A patent/JP7868034B2/ja active Active
- 2021-08-18 AR ARP210102328A patent/AR123284A1/es not_active Application Discontinuation
- 2021-08-18 AU AU2021328362A patent/AU2021328362A1/en not_active Abandoned
- 2021-08-18 PE PE2023000276A patent/PE20231318A1/es unknown
- 2021-08-18 TW TW110130426A patent/TW202227431A/zh unknown
- 2021-08-18 BR BR112023002662A patent/BR112023002662A2/pt unknown
- 2021-08-18 CN CN202180050343.7A patent/CN115956077A/zh active Pending
- 2021-08-18 IL IL300696A patent/IL300696A/en unknown
- 2021-08-18 CA CA3189816A patent/CA3189816A1/en active Pending
-
2023
- 2023-02-10 CL CL2023000428A patent/CL2023000428A1/es unknown
- 2023-02-15 CO CONC2023/0001670A patent/CO2023001670A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL300696A (en) | 2023-04-01 |
| BR112023002662A2 (pt) | 2023-03-14 |
| US20230322770A1 (en) | 2023-10-12 |
| MX2023001883A (es) | 2023-03-10 |
| CL2023000428A1 (es) | 2023-07-28 |
| AU2021328362A1 (en) | 2023-03-23 |
| EP4200015C0 (en) | 2026-04-29 |
| WO2022040293A1 (en) | 2022-02-24 |
| TW202227431A (zh) | 2022-07-16 |
| CN115956077A (zh) | 2023-04-11 |
| EP4200015A1 (en) | 2023-06-28 |
| CA3189816A1 (en) | 2022-02-24 |
| CO2023001670A2 (es) | 2023-02-27 |
| AR123284A1 (es) | 2022-11-16 |
| PE20231318A1 (es) | 2023-08-24 |
| ES3070309T3 (es) | 2026-06-15 |
| JP2023539136A (ja) | 2023-09-13 |
| EP4200015B1 (en) | 2026-04-29 |
| JP7868034B2 (ja) | 2026-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4200015B1 (en) | Substituted heteroaryl compounds useful as inhibitors of tlr9 | |
| US12590091B2 (en) | 1H-pyrrolo[3,2-C]pyridine and 1H-pyrrolo[2,3-C]pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis | |
| CN111819176A (zh) | 4-氮杂吲哚化合物 | |
| US12486267B2 (en) | Imidazo[1,2-A]pyridine and [1,2,4]triazolo[1,5-A]pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis | |
| EA047759B1 (ru) | Замещенные гетероарильные соединения, пригодные для применения в качестве ингибиторов tlr9 | |
| US20250163054A1 (en) | Substituted bicyclic heteroaryl compounds useful as inhibitors of tlr9 | |
| EA050843B1 (ru) | Замещенные гетероарильные соединения, пригодные для применения в качестве ингибиторов tlr9 | |
| WO2024102884A1 (en) | Substituted quinolone compounds useful as inhibitors of tlr9 | |
| WO2023159154A1 (en) | Substituted imidazopyridinyl compounds useful as inhibitors of tlr9 | |
| US20260001878A1 (en) | Substituted pyrrolopyridine compounds useful as inhibitors of tlr9 | |
| KR20250109202A (ko) | Tlr9의 억제제로서 유용한 치환된 벤즈이미다졸 화합물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
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| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| A201 | Request for examination | ||
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
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| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
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| D21 | Rejection of application intended |
Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE) |
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| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
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| E13 | Pre-grant limitation requested |
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| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
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| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
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| P11-X000 | Amendment of application requested |
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