KR20230005191A - 결손 간섭 바이러스 게놈 - Google Patents
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Abstract
본 발명은, 결함이 있는 간섭 바이러스 게놈(DVG), DVG를 포함하는 결함이 있는 간섭 입자, 및 그 생성 방법 및 용도에 관한 것이다.
Description
본 발명의 일부는 DARPA(방위고등연구계획국(Defense Advanced Research Projects Agency))이 부여한 계약 번호 HR0011-17-2-0023에 따른 정부 지원으로 이루어졌다. 미국 정부는 본 발명에 대해 특정 권리를 갖는다.
본 발명은 방위고등연구계획국(Defense Advanced Research Projects Agency(DARPA))이 부여한 DARPA 계약 번호 HR00111720023에 따른 정부 지원으로 이루어졌다. RNA 게놈을 가지고 있는 바이러스는 본질적으로 높은 오류율을 갖는 중합효소를 가지고 있다. 이러한 오류가 발생하기 쉬운 복제 과정의 결과로, 이러한 바이러스는 전장 바이러스 게놈 또는 점 돌연변이가 있는 게놈을 생성할 뿐만 아니라 결함이 있는 게놈(defective genome)을 생성한다. 절단(truncation), 삽입, 결실, 모자이크 또는 재배열된 게놈 및 카피백(copyback)/스냅백(snapback)을 포함하는, 다양한 유형의 결함이 있는 게놈이 설명되어 왔다. 결함이 있는 게놈의 대부분은 RNA 바이러스 복제의 막다른(dead-end) 부산물로 생각되는 반면, 이러한 결함이 있는 바이러스 게놈(DVG)의 서브세트는 많은 수의 감염성 자손 바이러스 입자의 생성을 방해한다.
높은 돌연변이율과 함께, 재조합은 RNA 바이러스 진화의 또 다른 주요 원동력이다. 비상동 재조합은 결함이 있는 바이러스 게놈(DVG)을 구성하는 절단(truncated) 및/또는 재배열된 바이러스 게놈을 생성할 수 있다. 1954년 Von Magnus가 A형 인플루엔자 바이러스에서 처음 기술한 DVG는 이후 모든 바이러스 과(family)에서 기술되어 왔다. 그의 게놈 또는 암호화된 기능의 일부가 부족하기 때문에, DVG는 전장 바이러스에 의해 암호화된 단백질을 이용하기 위해서는 세포를 그의 모체 바이러스와 함께 공동 감염시켜야 한다. 따라서, 복제 기계를 가로채거나 모체 바이러스에 의해 암호화된 단백질을 사용하는 DVG는 자원(resources)을 놓고 야생형 바이러스와 경쟁하여 모체 바이러스의 억제를 초래할 수 있다. 이러한 유형의 DVG는 종종 결함 간섭 입자(DIP)라고 한다. 또한, 많은 DVG는 포유류 및 무척추 동물 모두에서 강력한 면역 자극 잠재력을 가지고 있다. DVG는 급성 뎅기 바이러스 감염으로 고통받는 환자의 혈청에서 발견되었지만 그의 병태생리학적 역할은 아직 알려지지 않았다. 인간의 경우 DVG의 존재는 인플루엔자 바이러스 및 호흡기 세포융합 바이러스 감염의 경미한 질병 및 더 나은 결과와 관련이 있다. 이러한 이유는 모두 DVG를 항바이러스 요법으로 사용하는 것에 대한 새로운 관심을 정당화한다.
DVG는 대부분의 바이러스에 존재하는 것으로 기술되어 왔지만, DVG는 많은 바이러스 계열에서 관련성이 있거나 우세한 것으로 간주되지 않았다. 일반적으로, 임의의 주어진 바이러스에 대해 몇 가지 DVG만이 기술되어 왔다. 이러한 이전 보고는, 하나 또는 두 개의 DVG만을 선택하고 가장 짧거나 가장 풍부한 DVG로 편향되는 PCR 증폭과 같은 보다 고전적인 분리 방법에 의존했다. 이러한 DVG는 야생형 바이러스와 경쟁할 수 있는 능력의 측면에서 반드시 최상의 후보는 아니다. 따라서, 관심 있는 임의의 바이러스, 특히 인간 병원체에 적용될 수 있는 야생형 바이러스 감염과 경쟁하고 이를 방해하기 위한 최상의 DVG 후보를 식별하고 생성하기 위한 재현가능하고 합리적인 방법이 필요하다. 본 명세서에 개시된 발명은 이러한 필요성 및 기타 필요성을 충족시킨다.
본 발명자들의 통합된 실험적 진화 및 컴퓨터 접근방식은 임의의 바이러스에 대해 수천 개의 서로 다른 DVG를 식별한다. 첫째, 본 발명자들의 실험적 접근방식은 바이러스 집단에서 모든 가능한 DVG를 생성한다. 예상대로, 본 발명자들의 목록은 보다 고전적인 방법으로 식별된 것과 유사한 DVG를 포함한다. 둘째, 본 발명자들의 컴퓨터 분석을 통해, 시퀀스 데이터로부터 추정된 시간적 주파수(temporal frequencies)를 사용하여 결함이 있는 간섭 입자로 가장 잘 작동하는 DVG를 예측할 수 있다. 이러한 통합된 접근방식을 사용하여, 본 발명자들은 서로 다른 바이러스 과에 속하는 광범위한 바이러스에 대한 상위 후보 목록을 생성했으며, 그 중 최대 90%가 야생형 바이러스 복제를 방해할 수 있는 능력을 가짐을 확인했다.
본 개시는 DVG를 생성하는 방법을 제공하고 또한 그 방법에 의해 생성된 새로운 DVG를 제공한다. 치쿤구니야 바이러스(CHIKV), 지카 바이러스(ZIKV), 엔테로바이러스 71(EV71), 웨스트 나일 바이러스(WNV), 황열병 바이러스(YFV) 및 리노바이러스(RV), 및 코로나바이러스(CV)(예: SARS-CoV-2, 2019-nCov 또는 COVID-19로 명명된 최근 확인된 신종 코로나바이러스)로부터 생성된 DVG가 제공된다.
본 발명자들은 차세대 시퀀싱 방법에 이어 컴퓨터 분석을 사용하여 DVG를 확인하였으며, 핫스팟(hotspot) 분석은 결실 DVG(CHIKV, EV71, ZIKV 및 RV의 바이러스 게놈에서 내부 결실)인 다양한 DVG를 확인했다. 그 후, 이러한 DVG는 유전적으로 조작되었고 CHIKV, EV71, ZIKV 및 RV의 감염성 바이러스 역가를 감소시키는 그의 능력에 대해 테스트되었다. 성공적인 DVG 후보는 바이러스 감염의 심각성을 치료하고 제한하는 새로운 전략으로 사용될 수 있는 치료적 간섭 입자(TIP)로 사용될 가능성이 있다. 또한, WNV 및 YFV에 대한 DVG도 확인되었다. 다른 바이러스에 대한 성공을 기반으로, 이러한 DVG는 TIP로 사용될 가능성이 있다.
제1 측면에서, 결함이 있는 간섭 바이러스 게놈(DVG)을 생성하는 방법이 제공된다. 방법은 높은 감염 다중도(MOI)로 기준 감염성 바이러스(reference infectious visus)에 감염된 세포 및 고체 지지체를 포함하는 적어도 3개의 복제 시험관내 세포 배양물((replicate in vitro cell culture)의 제1 세트를 제공하고; 낮은 감염 다중도(MOI)로 기준 감염성 바이러스에 감염된 세포 및 고체 지지체를 포함하는 적어도 3개의 복제 시험관내 세포 배양물의 제2 세트를 제공하고; 복제 시험관내 세포 배양물의 제1 및 제2 세트를 정상 성장 조건 하에서 적어도 5회 계대 배양하고; 시험관내 복제 세포 배양물의 제1 및 제2 세트의 배지로부터 복수의 DVG 후보를 수집하고; 수집된 DVG 후보를 심층 시퀀싱(deep sequencing)하고; 복수의 DVG 후보로부터 DVG의 서브세트를 선택하는 것을 포함한다.
몇몇 구현예에서 방법은 높은 감염 다중도(MOI)로 기준 감염성 바이러스에 감염된 세포 및 고체 지지체를 포함하는 3개의 복제 시험관내 세포 배양물의 제3 세트를 제공하고/하거나; 낮은 감염 다중도(MOI)로 기준 감염성 바이러스에 감염된 세포 및 고체 지지체를 포함하는 적어도 3개의 복제 시험관내 세포 배양물의 제4 세트를 제공하고; 시험관내 세포 배양물의 제3 및/또는 제4 세트를 돌연변이 유발 조건 하에서 적어도 5회 계대 배양하거나; 또는 돌연변이 유발 유전자 표현형(mutator phenotype)을 갖는 기준 감염성 바이러스를 사용하여 상기 계대를 수행하기 위는 것을 추가로 포함한다.
몇몇 구현예에서, 복수의 DVG 후보로부터 DVG를 선택하는 것은 DVG 후보의 서열을 기준 감염성 바이러스의 게놈의 서열과 비교하고; 결실 또는 재배열인 적어도 하나의 스플라이싱 이벤트(splicing event)를 포함하는 게놈을 갖는 적어도 하나의 DVG 후보를 확인하고; 시퀀싱된 DVG 후보 게놈의 집단 중에서 적어도 하나의 스플라이싱 이벤트를 갖는 게놈을 갖는 적어도 하나의 DVG 후보의 상대 빈도를 결정하고; 그리고, a) 최소한 하나의 스플라이싱 이벤트가 낮은 MOI의 배양물에서보다는 높은 MOI의 배양물에서 더 풍부하고/하거나; b) 적어도 하나의 스플라이싱 이벤트가 적어도 2, 3, 4, 5, 6, 7, 8 또는 9개의 서로 다른 세포주에서 나타나고/나거나; c) 적어도 5, 10, 15 또는 20회의 계대 후, 적어도 12, 24 또는 36개의 독립적인 복제물 중 적어도 3개에서 적어도 하나의 스플라이싱 이벤트가 확인되고/되거나; d) 적어도 하나의 스플라이싱 이벤트가 결실 이벤트이고 그 결실의 뉴클레오티드 크기가 적어도 40, 42, 50, 100, 150, 200, 400, 600 또는 1000개의 뉴클레오티드이고/이거나; e) DVG의 오픈 리딩 프레임이 유지되고/되거나; f) 바이러스 복제에 필요한 구조적 도메인 및 기능이 DVG에서 유지되고/되거나; g) DVG가 기준 감염성 바이러스의 자가 복제 능력을 감소시키는 적어도 하나의 돌연변이를 포함하는 경우에 해당하는 적어도 하나의 DVG를 선택하는 것을 포함한다.
몇몇 구현예에서, DVG는 기준 감염성 바이러스에 대해 적어도 50%, 60%, 70%, 80% 또는 90%의 시험관내 억제 활성을 특징으로 한다. 몇몇 구현예에서, 기준 감염성 바이러스는 치쿤구니야 바이러스(CHIKV), 지카 바이러스(ZIKV), 엔테로바이러스 71(EV71), 리노바이러스(RV), 황열병 바이러스(YFV) 또는 웨스트 나일 바이러스(WNV)이다. 몇몇 구현예에서, 기준 감염성 바이러스는 CHIKV 인도양 계통(GenBank 수탁 번호 AM258994), CHIKV 카리브해 균주(GenBank 수탁 번호 LN898104.1), ZIKV 아프리카 균주 MR766(KY989511.1), EV71 Sep006(GenBank 수탁 번호 KX197462.1), RV-A01a(NC_038311.1), RV-A16 (L24917.1), RV-B14 (L05355.1), RV-C15 (GU219984.1), 웨스트 나일 바이러스 이스라엘 1998 및 YFV 균주, 황열 바이러스 아시비(YF-아시비) 균주 및 황열 바이러스 백신(YF-17D) 균주로 이루어진 군에서 선택된다. 몇몇 구현예에서, 기준 감염성 바이러스는 SARS-CoV-2이다(Zhu N 등, N Engl J Med., 2020 Jan 24). 몇몇 구현예에서, 세포는 아프리카 녹색 원숭이 신장 세포에서 유래된 세포주(선택적으로 Vero, 선택적으로 Vero-E6 세포주), 인간 근육에서 유래된 세포주(선택적으로 RD 세포주), 아기 햄스터 신장에서 유래된 세포주(선택적으로 BHK 세포주), 인간 배아 신장 세포로부터 유래된 세포주(선택적으로 HEK293T 세포주), 간암 세포로부터 유래된 세포주(선택적으로 Huh7 세포주), 및 자궁경부 선암종으로부터 유래된 세포주(선택적으로 H1-HeLa, 선택적으로 HeLa-E8 세포주)로 이루어진 군에서 선택된 포유동물 세포주이다. 몇몇 구현예에서, 세포는 이집트숲모기(Aedes aegypti)에서 유래된 세포주(선택적으로 Aag2 세포주), 흰줄숲모기(Aedes albopictus)에서 유래된 세포(선택적으로 C6/36 세포주) 및 흰줄숲모기에서 유래된 세포주(선택적으로 U4.4 세포주)로 이루어진 군에서 선택된 모기 세포주이다. 몇몇 구현예에서, 감염에 대한 낮은 MOI는 0.001 내지 0.1 PFU/세포, 특히 0.01 내지 0.1 PFU/세포이다. 몇몇 구현예에서, 감염에 대한 높은 MOI는 1 내지 100 PFU/세포이다.
또한, 본 발명의 방법에 의해 생성되는 DVG가 제공된다.
또한, 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201), 서열 번호: 21 (DG21: EV71 DVG 7238-7292), 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K), 서열 번호: 33 (ZIKV DVG-L), 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3), 서열 번호: 53 (CHIKV DVG-CA4), 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 92 (RV DVG C15-TIP-04), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19), 서열 번호: 87 (RV DVG B14-TIP-20), 서열 번호:93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K), 서열 번호: 104 (YFV DVG-L), 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5), 서열 번호: 110 (WNV DVG-6), 서열 번호: 111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는 DVG가 제공된다.
또한, 본 발명의 DVG를 포함하는 결함이 있는 간섭 입자가 제공된다.
또한, 대상체에서 바이러스 감염을 치료하는 방법으로서, 본 발명에 따른 적어도 하나의 DVG 또는 결함이 있는 간섭 입자를 효과적인 치료량으로 투여하는 것을 포함하는 방법이 제공된다.
몇몇 구현예에서, DVG는 RNA, 네이키드 RNA, 또는 나노입자 또는 지질과 같은 적절한 담체와 함께 제형화된 RNA로 투여된다.
몇몇 구현예에서, DVG는 패키징된 RNA, 바이러스-유사 입자(VLP) 또는 다른 패키징 담체로서 투여된다.
몇몇 구현예에서, DVG는 숙주에 적합한 전사 프로모터의 제어하에서 DNA로부터 전사된다.
몇몇 구현예에서, 적어도 하나의 DVG는 결함이 있는 간섭 CHIKV 게놈이다. 몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 CHIKV 게놈은: 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3) 및 서열 번호: 53 (CHIKV DVG-CA4)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 ZIKV 게놈이다. 몇몇 구현예에서, 적어도 하나의 간섭 ZIKV 게놈은: 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K) 및 서열 번호: 33 (ZIKV DVG-L)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 EV71 게놈이다. 몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 EV71 게놈은: 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201) 및 서열 번호: 21 (DG21: EV71 DVG 7238-7292)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 RV 게놈이다. 몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 RV 게놈은: 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 92 (RV DVG C15-TIP-04), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19) 및 서열 번호: 87 (RV DVG B14-TIP-20)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 YFV 게놈이다. 몇몇 구현예에서, 적어도 하나의 간섭 YFV 게놈은: 서열 번호:93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K) 및 서열 번호: 104 (YFV DVG-L)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 WNV 게놈이다. 몇몇 구현예에서, 적어도 하나의 간섭 WNV 게놈은: 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5) 및 서열 번호: 110 (WNV DVG-6)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
몇몇 구현예에서, 적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 CV 게놈, 예를 들어 결함이 있는 간섭 SARS-CoV-2 게놈이다. 몇몇 구현예에서, 적어도 하나의 간섭 SARS-CoV-2 게놈은: 서열 번호: 111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
또한, 대상체에 대한 CHIKV 감염의 치료 방법에 사용하기 위한 본 발명의 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자가 제공되며, 결함이 있는 간섭 게놈은: 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3) 및 서열 번호: 53 (CHIKV DVG-CA4)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
또한, 대상체에 대한 ZIKV 감염의 치료 방법에 사용하기 위한 본 발명의 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자가 제공되며, 결함이 있는 간섭 게놈은: 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K) 및 서열 번호: 33 (ZIKV DVG-L)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
또한, 대상체에 대한 EV71 감염의 치료 방법에 사용하기 위한 본 발명의 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자가 제공되며, 결함이 있는 간섭 게놈은: 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201) 및 서열 번호: 21 (DG21: EV71 DVG 7238-7292)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
또한, 대상체에 대한 RV 감염의 치료 방법에 사용하기 위한 본 발명의 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자가 제공되며, 결함이 있는 간섭 게놈은: 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 92 (RV DVG C15-TIP-04), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19) 및 서열 번호: 87 (RV DVG B14-TIP-20)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
또한, 대상체에 대한 YFV 감염의 치료 방법에 사용하기 위한 본 발명의 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자가 제공되며, 결함이 있는 간섭 게놈은: 서열 번호:93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K) 및 서열 번호: 104 (YFV DVG-L)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
또한, 대상체에 대한 WNV 감염의 치료 방법에 사용하기 위한 본 발명의 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자가 제공되며, 결함이 있는 간섭 게놈은: 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5) 및 서열 번호: 110 (WNV DVG-6)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
또한, 대상체에 대한 CV 감염의 치료 방법에 사용하기 위한 본 발명의 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자가 제공되며, CV 감염은 SARS-CoV-2에 의해 유발되고, 결함이 있는 간섭 게놈은: 서열 번호: 111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어진다.
또한, 본 발명에 따른 적어도 하나의 DVG 및 약학적으로 허용가능한 담체를 포함하는 약학적, 면역원성 또는 치료적 조성물이 제공된다.
또한, 본 발명에 따른 적어도 하나의 결함이 있는 간섭 입자 및 약학적으로 허용가능한 담체를 포함하는 약학적, 면역원성 또는 치료적 조성물이 제공된다.
또한, 본 발명의 면역원성 조성물을 포함하는 백신이 제공된다.
또한, DVG 또는 결함이 간섭 입자의 표적 바이러스에 감염된 환자의 치료를 위한 약물의 제조를 위한 본 발명의 DVG 또는 본 발명의 결함이 있는 간섭 입자의 용도가 제공된다.
또한, CHIKV에 감염된 환자의 치료를 위한 약물의 제조를 위한 본 발명의 DVG 또는 본 발명의 결함이 있는 간섭 입자의 용도가 제공된다.
또한, ZIKV에 감염된 환자의 치료를 위한 약물의 제조를 위한 본 발명의 DVG 또는 본 발명의 결함이 있는 간섭 입자의 용도가 제공된다.
또한, EV71에 감염된 환자의 치료를 위한 약물의 제조를 위한 본 발명의 DVG 또는 본 발명의 결함이 있는 간섭 입자의 용도가 제공된다.
또한, RV에 감염된 환자의 치료를 위한 약물의 제조를 위한 본 발명의 DVG 또는 본 발명의 결함이 있는 간섭 입자의 용도가 제공된다.
또한, YFV에 감염된 환자의 치료를 위한 약물의 제조를 위한 본 발명의 DVG 또는 본 발명의 결함이 있는 간섭 입자의 용도가 제공된다.
또한, WNV에 감염된 환자의 치료를 위한 약물의 제조를 위한 본 발명의 DVG 또는 본 발명의 결함이 있는 간섭 입자의 용도가 제공된다.
또한, CV, 특히 SARS-CoV-2에 의해 감염된 환자의 치료를 위한 약물의 제조를 위한 본 발명의 DVG 또는 본 발명의 결함이 있는 간섭 입자의 용도가 제공된다.
또한, 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201), 서열 번호: 21 (DG21: EV71 DVG 7238-7292), 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K), 서열 번호: 33 (ZIKV DVG-L), 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3), 서열 번호: 53 (CHIKV DVG-CA4), 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 92 (RV DVG C15-TIP-04), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19), 및 서열 번호: 87 (RV DVG B14-TIP-20), 서열 번호:93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K), 서열 번호: 104 (YFV DVG-L), 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5), 서열 번호: 110 (WNV DVG-6), 서열 번호: 111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는 폴리뉴클레오티드가 제공된다.
또한, 본 발명의 폴리뉴클레오티드를 포함하는 발현 벡터 또는 플라스미드가 제공된다.
또한, 본 발명에 따른 DVG를 생성하는 세포주가 제공된다.
본 발명은 이하의 비제한적인 실시예들을 통하여 더 상세히 이해될 수 있을 것이다.
실시예
실시예 1: 방법
바이러스의 성장
전통적으로, DVG는 바이러스가 높은 감염 다중도(MOI)로 계대되는 경우에 관찰되었다. 대부분의 공개된 연구(published work)는 적은 수의 계대 및 적은 수의 복제물로부터 DVG를 식별함으로써, 일반적으로 가장 큰 결실이 있는 가장 짧은 DVG를 식별하는 쪽으로 편향된 방법(예: RNA 게놈의 5' 및 3' 말단에 걸쳐 있는 프라이머를 사용한 RT-PCR 증폭)에 의해 단일의 가장 풍부한 DVG의 식별하는 것을 기반으로 한다. 이것은 임의의 주어진 바이러스의 경우 소수의 DVG만이 생성된다는 개념으로 이어졌다. 본 발명자들은 DVG 수는 서열에 따라 수백에서 수천에 이르고, 간섭을 위한 최상의 후보 DVG가 단일 성장 조건에서 나타나는 단일의 가장 풍부한 DVG일 필요는 없다는 것을 확인했다. 본 발명자들의 방법에서, 야생형 바이러스는 낮은(대조군) MOI 조건과 높은 MOI 조건 모두에서, 그리고 결함이 있는 게놈의 생성을 증가시키는 것으로 밝혀진 돌연변이 유발 조건에서 계대된다. 이러한 돌연변이 유발 조건에는 천연 야생형 바이러스보다 더 많은 오류를 생성하는 바이러스의 돌연변이 유발 변이체(mutator variant), 또는 이러한 오류율을 증가시키는 외적 처리(예: 리바비린, 5-플루오로우라실, 5-아자시티딘, T705와 같은 염기 유사체, 또는 온도를 높이거나 Mn++로 배지를 보충하는 것과 같은 처리)가 포함된다. 바이러스는 최대 10회의 계대 동안 높은 생물학적 복제 수(3, 12, 24 또는 36)로 계대된다. 본 발명자들은 필요한 데이터를 생성하는데 5회의 계대이면 충분하다는 것을 관찰했다. 또한, 본 발명자들은 세포주와 숙주 사이에서 선호되는 DVG 유형의 차이를 관찰했기 때문에 다양한 세포 유형 또는 다양한 숙주를 사용하는 것을 권장한다
DVG 후보의 식별
계대 시리즈(passage series) 유래의 바이러스는 전체 게놈에서 발생하는 모든 결실 또는 재배열을 특성 규명하기 위해 심층 시퀀싱된다. 해당 위치에서의 리드(read)의 총수 대비 특정 결실/재배열을 설명하는 리드의 수는 해당 결실이 전체 바이러스 집단에 존재하는 빈도의 대용물(proxy)로 사용된다. 이러한 방법을 사용하여 임의의 주어진 바이러스에 대해 수백에서 수천 개의 서로 다른 DVG가 확인된다. 본 발명자들은 컴퓨터 도구를 사용하여 이러한 DVG 중 어떤 것이 높은 빈도수 및 풍부도(abundance)로서 풍부하게 발생하고 복제물(replicate) 간에 중복되는지를 식별하여 추가 테스트를 위해 10 내지 20개의 최상의 후보를 선택한다.
본 발명자들은, 좋은 후보는 야생형에 비해 상대적으로 높은 복제 적합도(replication fitness)를 가지며, 야생형과 함께 캡슐화되거나 세포에서 세포로 계대되며, 야생형과 경쟁하여 및 이를 방해하고, 번식에 필요한 도메인 및 기능을 유지하고, 다양한 세포 유형 및 숙주에서 적합성을 유지한다는 가정에 기반하여, 하기 기준 및 근거를 사용하여 어떤 DVG가 최상의 TIP 후보가 될 것인지 예측한다.
집단에서 더 높은 빈도로 발생하는 DVG는 생존 가능성이 가장 높고(야생형 바이러스에 의해 복제하거나 복제될 수 있음) 야생형 바이러스와 경쟁할 가능성이 더 높다.
계대 시리즈에 걸쳐 발생하는 DVG는 야생형과 경쟁할 수 있고 VLP로 캡슐화되어 새로운 세포를 감염시킬 가능성이 가장 높다.
3개 이상의 생물학적 복제물에서 발생하는 DVG는 야생형과 경쟁하기에 충분히 높은 적합성을 가질 가능성이 더 높으며 복제 및 번식에 필요한 구조적 및 기능적 요소를 보유하고 있을 가능성이 높다.
하나 이상의 세포 유형 또는 숙주에서 발생하는 DVG는 다양한 세포 조건에서 생존할 가능성이 더 높다.
높은 MOI 또는 돌연변이 유발 조건 대(versus) 낮은 MOI 조건에서 더 높은 빈도로 발생하는 DVG는 야생형 바이러스의 진정한 경쟁자가 될 가능성이 더 높다.
또한, 본 발명자들은 결실의 시작 및 중지(중단점)의 뉴클레오티드 위치를 게놈의 예측된 RNA 구조와 일치시킨다(실시예 2, 도 8 내지 도 22 참조). 본 발명자들은 작은 결실이 전체 게놈에 걸쳐 무작위로 발생하는 반면, 위의 기준을 충족하는 DVG 후보에서의 더 큰 결실이 주요 구조적 부위에서 발생한다는 것을 확인했다. 즉, 바이러스의 예측된 RNA 구조를 사용하여 대규모 결실이 발생할 위치 및 이것이 생존가능한 DVG 후보가 될 것인지 여부를 예측할 수 있다.
본 발명자들은 DVG가 둘 이상의 메커니즘에 의해 간섭 및 작동할 수 있음을 관찰했다. 고전적인 견해는더 짧은 게놈이 더 빨리 복제하기 때문에 더 짧은 DVG가 야생형으로부터 복제 기계를 훔치고 야생형을 압도한다는 것이다. 그러나, 본 발명자들이 관찰한 추가 메커니즘은 하기의 DVG를 포함한다: 일반적으로 요구되는 것보다 더 많은 몇몇 바이러스 단백질을 제공함으로써 야생형에 이용가능한 바이러스 단백질의 화학량론(stoichiometry)을 변경하는 DVG; 세포 반응 및 위험 신호를 유도하는 잘못 접힌 단백질을 생성하는 DVG; 야생형 복제 및 조립을 '중독(poisoning)'시킴으로써 생존할 수 없는 야생형 바이러스를 초래하는 결함이 있는 단백질을 암호화하는 DVG; 더 쉽게 위험 신호로 감지되기 때문에 선천성 면역 및 기타 세포 반응을 유도하는 DVG. 이상적인 DVG는 이러한 메커니즘 중 하나, 몇몇 또는 모두를 제시할 수 있는 것이거나, 이러한 메커니즘 중 몇몇을 각각 나타내는 DVG의 칵테일로 구성될 수 있다.
이러한 접근 방식을 사용하여 본 발명자들은 하기 바이러스 및 균주의 전체 DVG 프로필(수백에서 수천)을 얻었다:
치쿤구니야 바이러스, 카리브해 및 인도양 섬 균주;
지카 바이러스, 아프리카 균주;
엔테로바이러스 A71;
리노바이러스 A01a, A16, B14 및 C15;
황열병 바이러스 17D 백신 균주 및 아시비; 및
웨스트 나일 바이러스.
코로나바이러스, 특히 SARS-CoV-2 균주(BetaCoV/France/IDF0372/2020).
이러한 목록으로부터, 위에서 언급한 선택 기준을 사용하여, 본 발명자들은 각 바이러스 유형에 대한 최상의 후보를 식별했다. 상위 후보의 상위 서열은 첨부된 정보 서열 목록에 제공되어 있다. 상위 후보 목록이 설정되면, DVG의 감염성 클론이 만들어지고 시험관내에서 테스트된 다음 생체내에서 테스트된다. 본 발명자들의 결과는 이러한 식별 및 하향 선택(down-selection) 방법이 매우 높은 성공률을 가지며 후보의 50 내지 90%가 시험관내에서 야생형 바이러스에 대한 억제 활성을 나타냄을 보여준다.
방법의 예
방법의 예들이 도 1 내지 7에 도시되어 있다.
도 1은 낮은/높은 MOI 또는 돌연변이 유발 조건에서의 계대 방법을 도시한다.
도 2는 결실을 검출하기 위한 생물정보학 파이프라인(bioinformatics pipeline)을 도시한다.
도 3은 결실의 히트 맵 예를 도시한다.
도 4는 시작/중지 예를 도시한다.
도 5는 샘플 예에서의 특정 결실을 도시한다.
도 6은 세포 유형 예의 차이점을 도시한다.
도 7은 돌연변이 유발 조건의 샘플을 도시한다.
실시예 2: 엔테로바이러스 A71(EV71)
EV71 내에서 발생하는 모든 DVG의 생성 및 특성규명
12웰 플레이트에 Vero 세포를 접종하여 다음날 약 90%의 컨플루언시(confluency)에 도달하도록 하였다. 12개의 웰을 Lipofectamine 2000(Life Technologies사)을 사용하여 500 ng pCAGGS-EV71_Sep006(EV71 Sep006 - GenBank: KX197462.1)으로 개별적으로 형질감염시켜서 안정적인 배경으로부터 감염성 바이러스를 생성했다. 이어서, Vero 세포를 300 ㎕의 바이러스 상층액으로 감염시켰다. 또는 Vero 또는 RD 세포의 12웰 플레이트를 고정된 낮은 부피(3 ㎕) 또는 높은 부피(300 ㎕)로 감염시켰다. 웰이 >90% CPE를 나타낼 때까지 세포를 37℃ 및 5% CO2에서 인큐베이션하였다. 두 번의 동결-해동 사이클 후에, 세포의 새로운 합류 단층(confluent monolayer)을 감염시켰다. 이것은 12개의 복제물을 사용하여 12회 반복하였다.
상층액을 원심분리(13,000g, 30분)한 다음, RNaseA 처리(1 ㎕; Thermo, 37℃에서 3시간)하거나 또는 PEG 침전(10 mM HEPES(Sigma사), pH 8.0, 0.8% PEG8000(Sigma사) 및 50 mM NaCl(Sigma사))시키고, 1시간 동안 13,500 x g에서 추가로 원심분리하였다. 클리어링된 상층액으로부터 RNA를 Trizol(Sigma사)을 사용하여 추출하였다.
샘플 RNA를 NEBNext RNA First Strand Buffer(NEB사)를 사용하여 단편화하고 94℃에서 15분 동안 열-단편화했다. 제조사의 지침에 따라 NEBNext Ultra II NEB(Non-Directional RNA Library Prep Kit for Illumina)를 사용하여 RNAseq 라이브러리를 생성했다. 샘플의 다중화(multiplexing)를 가능하게 하기 위해, NEBNext Multiplex Oligos for Illumina(NEB사)를 사용하여 인덱스를 생성했다. 생성된 라이브러리는 Illumina NextSeq 500/550 Mid Output Reagent Cartridge v2를 사용하여 Illumina NextSeq500 Sequencer에서 및 150 사이클 단일-엔드 리드를 사용하여 Illumina NextSeq 500/550 Mid Output Flow Cell Cartridge v2.5에서 풀링 및 시퀀싱하였다. 얻어진 서열을 BBMap 제품군 기반 컴퓨터 파이프라인을 사용하여 분석하였다.
초기에 식별된 DVG를 복제, 계대 및 세포주 사이의 재발을 통해 분석하였다. 이는 간섭 활성에 대한 분석을 위해 앞으로 취해진 15개 DVG의 목록을 생성했으며 따라서 이러한 DVG를 TIP로 사용할 수 있는지 여부를 결정했다. 15개의 식별된 DVG 중에서 6개는 중단점(breakpoint) 이후에 넌센스 돌연변이를 일으키는 결실을 초래했다. 대조군으로서, 이러한 6개의 DVG의 결실 길이는 오픈 리딩 프레임을 유지하도록 조정하였다. 따라서, 평가된 후보 목록은 21개의 DVG였다.
도 8: EV71의 연속적 계대. Vero 또는 RD 세포의 12개 복제물을 3 ㎕(낮음) 또는 300 ㎕(높음)의 고정 부피로 EV71로 감염시켰다. 세포가 >90% CPE를 보일 때까지 감염을 인큐베이션하였다. 바이러스는 12개 계대에 걸쳐 연속적으로 계대하였다. TCID50을 사용하여 바이러스 역가를 측정하고 이러한 고정 부피로 얻을 수 있는 MOI 범위를 계산했다.
도 9: EV71의 결실 히트멥. 연속적 계대 유래의 샘플을 RNAseq로 분석하고 BBMap 기반 파이프라인을 사용하여 결실을 검출했다. 그 후, 각 세포주, 조건 및 계대에서의 개별 복제물을 풀링하고 시각화하여 바이러스 게놈의 위치에 대한 각각의 결실된 뉴클레오티드의 빈도의 히트맵을 표시했다. 전반적으로 결실 핫스팟은 비교적 작았고 종종 게놈과 관련하여 뚜렷한 위치를 가졌다.
도 10: IRES의 결실 핫스팟. 결실 핫스팟을 바이러스 게놈에 정렬하면, EV71의 5' UTR에 위치하는, 계대 및 세포주에 걸쳐서 강력한 핫스팟이 있다. 더욱 자세히 분석하면, 이러한 핫스팟은 RNA를 바이러스 다단백질로 효율적으로 번역하는데 필요한 IRES의 스템 루프 IV(빨간색 원)의 상단에 해당한다.
도 11: 캡시드의 결실 핫스팟. EV71의 많은 결실 핫스팟은 게놈의 캡시드 영역에 위치한다. 이러한 영역은 바이러스의 구조 단백질에 해당한다. 빈번하게 결실된 영역의 예는 박스(검정색)로 표시되어 있으며 게놈에 대한 결실의 도식(schematic)은 주요 캡시드 단백질 VP1 내의 결실 및 VP3 및 VP1의 대부분의 영역에 걸쳐 있는 더 큰 결실을 보여준다.
도 12: 3C의 결실 핫스팟. EV71의 3C 단백질은 이중 기능을 가지고 있는데, 이는 다단백질을 이의 개개의 기능적 단백질로 절단하는 바이러스의 주요 프로테아제이다. 동시에 3C 단백질은 주요 인터페론 길항제이기도 하므로, 세포의 선천적 면역 반응에 대항하는 주요 단백질이다. 그 단백질의 길이는 183개 아미노산이며, 단백질의 3C 활성면(active side)은 최소 6개 잔기(빨간색으로 표시)로 구성된다. 흥미롭게도, 3C의 결실 핫스팟은 활성면과 겹치는 것으로 보이며, 이는 결실이 그 단백질을 기능하지 않게 만들 것임을 시사한다.
도 13: 3D의 결실 핫스팟. 바이러스 중합효소는 3D 단백질에 있다. 결실 히트맵은 단백질 전체에 걸쳐 다양한 작은 결실이 있음을 나타낸다. 흥미롭게도, 오픈 리딩 프레임의 3'-말단을 향한 두 개의 히트 신호가 있으며, 이 신호는 폴리오바이러스에서도 확인되고 그 바이러스의 충분한 복제에 관여하는 두 개의 예측된 스템-루프 구조 내에 위치한 것으로 보인다.
결실 후보 및 기타 DVG를 추가로 조사하여, 관찰된 결실된 서열이 특정 뉴클레오티드 시그니처(signature) 또는 RNA 구조와 상관관계가 있는지 여부를 결정했다.
도 14: 중단점 이후의 뉴클레오티드의 상보성. 중단점 주변의 뉴클레오티드의 상보성을 분석하기 위해, 뉴클레오티드를 개별적으로 평가하고 시작-중단점 이후의 위치 1 내지 6을 끝-중단점 이후의 위치 1 내지 6에 대해 테스트했다. 그래프는 y축에서 상보성의 빈도를 보여주고 x축에서 결실 길이, 즉 이러한 크기 이상의 모든 결실에 대한 뉴클레오티드 임계값을 보여준다. 41개 이하의 뉴클레오타이드의 결실은 중단점 주변의 상보성에 의존하지 않으며, 이는 오히려 작용 모드로서 게놈을 따른 폴리머라제의 미끄러짐(slipping)을 시사한다. 상보성의 빈도는 점진적으로 증가하는데, 이는 결실이 길수록 중단점 주변의 상보성이 더 중요함을 나타낸다. 79개 뉴클레오티드보다 긴 결실의 경우, 약 95%가 첫 번째 뉴클레오티드 위치를 갖고 약 88.5%가 서로 상보적인 처음 세 개의 뉴클레오티드 위치를 갖는다. 무작위 이벤트는 약 25%인 것으로 예상된다.
도 15: 중단점 주변의 뉴클레오티드의 상보성은 바이러스 전반에 걸쳐 보존된다. 중단점 주변의 상보성의 중요성을 CHIKV 카리브해 균주(CHIKVc), CHIKV IOL(CHIKVi), ZIKV, EV71 및 RV-B14(RV)에 대하여 분석하였다. y축은 상보성의 빈도를 나타내고, x축은 각각 시작 위치와 중지 위치 주변의 뉴클레오티드의 정렬을 나타낸다. 흥미롭게도, 상보성의 양성 신호 바로 옆의 결실은 중단점 직전의 뉴클레오티드 위치에서의 1% 미만의 음성 신호와 일치했다. 중단점 또는 프라이머 이후의 서로 상보적인 뉴클레오티드의 수는 개개의 바이러스에 따라 다르다. CHIKV의 경우 약 2개 뉴클레오티드, ZIKV의 경우 3 내지 5개 뉴클레오티드, EV71의 경우 3 내지 4개 뉴클레오티드, RV의 경우 2개 뉴클레오티드이다.
도 16: 42개 뉴클레오티드 이상의 결실에 대한 상보성 맵은 EV71이 "해제(disassociate) 및 재-프라임(re-prime)" 메커니즘을 사용한다는 것을 보여준다. 거의 동일하지 않은 "프라이머" 서열 직전의 위치에 강한 음성 신호가 있다(시간의 약 0.5% - 약 25%는 무작위임). 따라서, 프라이머 길이는 다양하지만, EV71의 평균 길이는 3개 뉴클레오티드인 것으로 보인다.
도 17: 중단점 주변의 상보성 서열의 예: 중합효소가 전사에 다시 관여하고 전사를 다시 개시하는데 사용할 수 있는 중단점 주변의 상보적 뉴클레오티드 서열을 활용함으로써 두 상보적 게놈 영역 사이의 서열의 내부 결실을 초래하는 DVG의 세 가지 예가 도시되어 있다.
도 18: 중단점 주변의 상보적 뉴클레오티드는 종종 RNA 이차 구조의 루프에 위치한다. NA 접힘(오른쪽)을 사용하여 EV71의 전체 게놈 RNA 2차 구조를 모델링하였다. 결실은 그 구조에 매핑하였으며 핫스팟은 종종 2차 구조의 루프 구조와 일치했다. 중단점 주변의 상보적 서열과 함께, 이것은 상보적 서열이 잠재적 프라이머로서 기능하여 결합하도록 하고 프라임-재정렬(prime-realign) 접근법을 사용하여 전사의 재개시를 허용하도록 이러한 서열이 짝을 이루지 않도록 할 수 있다. 중합효소는 "공여체" 측에서는 불안정한 것으로 보이며, 중합효소가 상보적 프라이머를 사용하여 게놈("수용체")의 다른 위치에 재부착할 수 있고 전사를 계속할 수 있을 때까지 복제가 중단되어 내부 결실이 발생한다.
도 19: EV71 DVG 서열들: 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201) 및 서열 번호: 21 (DG21: EV71 DVG 7238-7292).
EV71 DVG 서열들을 다음의 표에 나타내었다.
| 서열 번호 | 바이러스 | 명칭 | DVG 크기 | 도면 |
| 1 | EV71 | 293-390 | 7334 | 도 19 |
| 2 | EV71 | 294-404 | 7321 | 도 19 |
| 3 | EV71 | 1746-2895 | 6282 | 도 19 |
| 4 | EV71 | 1752-2894 | 6289 | 도 19 |
| 5 | EV71 | 1752-2896 | 6288 | 도 19 |
| 6 | EV71 | 1880-6487 | 6288 | 도 19 |
| 7 | EV71 | 1880-6488 | 2823 | 도 19 |
| 8 | EV71 | 3513-6516 | 4428 | 도 19 |
| 9 | EV71 | 5475-5634 | 7272 | 도 19 |
| 10 | EV71 | 5610-6876 | 7165 | 도 19 |
| 11 | EV71 | 5610-6877 | 7164 | 도 19 |
| 12 | EV71 | 5746-5821 | 7356 | 도 19 |
| 13 | EV71 | 6322-6356 | 7397 | 도 19 |
| 14 | EV71 | 6322-6358 | 7395 | 도 19 |
| 15 | EV71 | 6728-6779 | 7380 | 도 19 |
| 16 | EV71 | 6966-7012 | 7385 | 도 19 |
| 17 | EV71 | 6966-7014 | 7383 | 도 19 |
| 18 | EV71 | 7098-7122 | 7407 | 도 19 |
| 19 | EV71 | 7165-7200 | 7396 | 도 19 |
| 20 | EV71 | 7165-7201 | 7395 | 도 19 |
| 21 | EV71 | 7238-7292 | 7377 | 도 19 |
도 20: EV71 DI 후보 공동 형질감염
바람직한 EV71 DVG는: 서열 번호: 1 (EV71 DVG 293-390,DG1), 서열 번호: 3 (EV71 DVG 17646-2895, DG3), 서열 번호: 14 (EV71 DVG 6322-6358, DG14), 서열 번호: 15 (EV71 DVG 6728-6779, DG15), 서열 번호: 18 (EV71 DVG 7098-7122, DG18), 및 서열 번호: 21 (EV71 DVG 7238-7292, DG21)로 구성되는 군으로부터 선택된다.
EV71 TIP 후보는 시험관내에서 야생형 바이러스를 억제한다
24웰 플레이트에 293T 세포로 접종하여 다음 날에 약 90% 컨플루언시에 도달하도록 하였다. 200 ng의 pCAGGS-EV71_Sep006을 대조군 플라스미드(pcDNA3-RFP) 또는 개별 DVG로 단독으로 형질감염시켰다. 다른 플라스미드는 1:1, 5:1 또는 10:1(DVG 대 WT)의 몰 비율로 야생형 EV71 회수 플라스미드와 혼합했다. 형질감염은 4회 반복 수행하였다. 플라스미드를 Lipofectamine 2000(Life Technologies사)을 사용하여 형질감염시키고, 배지를 6시간 후에 교체하고, 샘플을 형질감염 4일 후에 수확하였다. 바이러스 역가는 TCID50 또는 플라크 분석에 의해 평가하였다. 간단히 말해서, TCID50의 경우, 96웰 플레이트에 Vero 세포 및 연속적으로 희석된 바이러스 상청액을 접종하고 2회 동결 해동하고 샘플을 추가하고 37℃ 및 5% CO2에서 7일 동안 인큐베이션했다. 플라크 분석을 위해, 바이러스는 감염 24시간 전에 접종된 VeroE6 세포를 사용하여 24웰 플레이트에 적정하였다. 10배 연속 희석된 바이러스 샘플을 1시간 인큐베이션한 후, 2% FBS(LifeTechnologies사), MEM(LifeTechnologies사) 및 0.05% 아가로스(Thermo사)를 사용하여 세포에 반고체 아가로스 오버레이(overlay)를 덮었다. 플레이트를 37℃ 및 5% CO2에서 72시간 동안 인큐베이션했다. 두 방법 모두의 경우, 4% 포르말린으로 고정된 세포 및 플라크를 크리스탈 바이올렛을 사용하여 시각화했다.
실시예 3: 지카 바이러스(ZIKV)
지카내에서 발생하는 모든 DVG의 생성 및 특성규명
방법: DVG의 식별에 사용된 바이러스는 지카 바이러스(ZIKV)의 아프리카 균주 MR766이다. DVG를 식별하기 위해, ZIKV를 Vero, BHK 또는 C6/36 세포에서 높은 감염 다중도로 계대하였다. 간단히 말해서, 70 내지 80% 컨플루언시에 도달하도록 접종된 세포를 5 PFU/세포의 초기 MOI로 감염시켰다. 감염 후 3일(Vero, BHK) 또는 5일(C6/36)에, 세포 배양 상층액을 원심분리에 의해 정화하고 300 ㎕의 상층액을 사용하여 미경험(naive) 세포를 감염시켰다(계대 2). 낮은 MOI 조건의 경우, 3 ㎕의 바이러스 상층액을 후속 계대에서 감염에 사용했다. 계대를 12회 반복하였다. 클리어링된 상층액으로부터 RNA를 추출(TRIzol)하여 차세대 시퀀싱에 사용했다. RNA Library Prep 키트(Illumina사)를 사용하여 제조한 라이브러리를 150 사이클 단일 말단 리드를 사용하여 Illumina NextSeq500 시퀀서에 로드했다. 얻은 리드(read)는 위에서 설명한 컴퓨터 파이프라인을 사용하여 분석하였다.
샘플의 심층 시퀀싱 및 컴퓨터 분석을 통해 게놈 전체의 모든 결실 핫스팟 및 집단 내에서 발생하는 특정 DVG를 식별했다. 도 21에서, 각 패널은 상이한 계대 수를 나타내는 반면, 각 패널의 각 행은 BHK 세포에서 수행된 상이한 생물학적 복제물이다. 분석 결과 여러 복제물에 공통적인 결실 핫스팟이 확인되는데, 이는 이러한 DVG가 무작위 결실을 갖는 다른 많은 DVG보다 적합성이 더 높음을 시사한다. 또한, 결실은 계대에 걸쳐서 발생하는데, 이는 해당 DVG가 더 높은 적합성이며 새로운 세포를 감염시키기 위해 패키징될 수 있음을 시사한다. 도 22에서, Vero 세포에서 계대된 바이러스에 대해 동일한 분석을 수행하였다. 데이터에 따르면, 초기 계대에서는 몇몇 결실 및 DVG가 BHK 세포에서도 발견되지만, 특정 결실 핫스팟(5' 게놈의 5'말단)은 이러한 세포주에 고유하며 빈도의 측면에서 다른 결실을 대신한다. 도 21에서, 결실 핫스팟은 Vero 세포에서 관찰된 패턴과 유사한 ZIKV 게놈의 5' 말단에서 결실된 영역을 나타낸다. 종합하면, 데이터는 다양한 조건에서 DVG의 전체 범위와 전반적인 적합성을 결정하기 위해 둘 이상의 세포주 또는 숙주를 사용하는 것이 중요하다는 것을 보여준다. 다양한 세포 유형에서 발견되는 일반적인 DVG 및 독특한 DVG에 대한 추가 비교가 도 24에 도시되어 있으며, 여기에서는 Vero(왼쪽 패널)와 C6/36(오른쪽 패널)에서 자란 지카가 비교되어 있다. 이 도면은 세포 유형 간에 많은 차이점이 있음을 강조할 뿐만 아니라, 계대 시리즈가 진행됨에 따라 나타나는 두 세포 유형 모두에서의 결실 클러스터를 보여준다(이러한 DVG의 높은 적합성을 암시함).
이러한 분석 및 다른 분석으로부터, 본 발명자들은 선택 기준에 따라 TIP 후보의 목록을 선택했다. 후보는 A, B, C, D, E, F, G, H, K 및 L로 명명하였다. 후보는 다양한 크기에 걸쳐 있으며 결실은 게놈의 다양한 위치에서 발생하여, 기존의 계대 및 분리를 사용하여 식별할 수 있는 것보다 더 넓은 어레이의 TIP 후보를 나타낸다.
도 21. BHK-21 세포에서 DVG 식별. 각 계대 유래의 ZIKV 집단을 심층 시퀀싱(RNAseq)하였으며 ZIKV 게놈 전체에 걸쳐 각각의 결실된 뉴클레오티드 위치(x축)의 정규화된 빈도가 히트맵으로 도시되어 있다. 각 패널은 모든 높은 MOI 복제물에 대한 상이한 계대수를 나타낸다. 각 패널 내의 각 행은 12개의 생물학적 복제물의 각각을 나타낸다.
도 22. Vero 세포에서 DVG 식별. 각 계대 유래의 ZIKV 집단을 심층 시퀀싱(RNAseq)하였으며 ZIKV 게놈 전체에 걸쳐 각각의 결실된 뉴클레오티드 위치의 정규화된 빈도가 히트맵으로 도시되어 있다. 각 패널은 모든 높은 MOI 복제물에 대한 상이한 계대수를 나타낸다.
도 23. C6/36 세포에서 DVG 식별. 각 계대 유래의 ZIKV 집단을 심층 시퀀싱(RNAseq)하였으며 ZIKV 게놈 전체에 걸쳐 각각의 결실된 뉴클레오티드 위치의 정규화된 빈도가 히트맵으로 도시되어 있다. 각 패널은 모든 높은 MOI 복제물에 대한 상이한 계대수를 나타낸다.
도 24: ZIKV DVG 핫스팟의 식별. 결실의 시작(x축) 및 중지(y축) 위치가 Vero(A) 및 C6/36(B) 세포 계대에 대해 도시되어 있다. 데이터 포인트는 계대수에 따라 착색되어 있다. 특히 Vero 세포에서 대략 500 내지 3000개 뉴클레오티드 시작-중지에 시작 및 중지 위치가 있는 영역에서 명확한 핫스팟이 관찰되었다.
도 25: 후보 ZIKV DVG의 개략도. ZIKV 후보 DVG를 계대 전체에 걸친 그의 중복성(redundancy) 및 빈도를 기반으로 선택하였다. 왼쪽의 각 문자는 DVG의 임시 명칭을 나타낸다.
지카 TIP 후보 K는 그 자체로는 복제가 불가능하다.
방법: DG의 복제 능력을 평가하기 위해 DG K-기반 레플리콘 작제물을 설계하였다. 플라비바이러스 레플리콘용으로 일반적으로 설계된 바와 같이 구조 단백질 대신에 리포터가 삽입된 Nanoluc 리포터 작제물을 생성하였다(도 29A). 시험관내 전사에 의해 DNA 클론으로부터 RNA를 생성하였고, Vero 세포에 형질감염시켰다. 형질감염 후 6, 24, 48 및 72시간에 세포에서 nanoluc 리포터 활성을 측정했다.
그 결과는 리포터 활성의 증가가 시간 경과에 따라 관찰되는 WT 레플리콘과 달리, DG K 레플리콘은 증가를 나타내지 않았음을 보여준다(도 29B). 그러나, 감염된 세포에서 분석을 반복했을 때 레플리콘 활성이 회복되었는데(도 29C), 이는 DG가 그 자체로는 복제가 불가능하지만 복제를 위해 WT를 필요로 함을 시사한다. 이러한 결과는 잠재적 TIP로서 DVG의 사용의 안전성의 측면에서 중요한 의미를 갖는다.
도 27. ZIKV DG는 그 자체로는 복제가 불가능하고 복제를 위해 WT에 의존한다. (A) 레플리콘 작제물의 개략도. 야생형 레플리콘의 경우, C38 및 E30은 각각 C의 N-말단 38개 아미노산 및 C-말단 30개 아미노산 E 단백질을 나타낸다. DG 레플리콘의 경우, Pr38 및 NS198은 각각 Pr 및 NS1 단백질의 N-말단 38개 아미노산 및 C-말단 98개 아미노산을 나타낸다. Nanoluc2A는 수족구병 바이러스 2A 프로테아제가 뒤따르는 nanoluc 리포터 서열을 나타낸다. 또한, 비활성 돌연변이 레플리콘(NS5△GDDAAA 레플리콘)도 제작하였다. (B) 야생형 및 DG 레플리콘 분석. 동일한 양의 야생형, NS5△GDDAAA 및 DG 레플리콘 RNA를 Vero 세포에 형질감염시키고, 형질감염 후 표시된 시간에서 상대적 광 단위(RLU)를 측정했다. (C) 감염되거나 감염되지 않은 세포에서 DG 레플리콘 분석. 동일한 양의 DG 레플리콘 RNA를 무경험 또는 감염된 Vero 세포(MOI 1 PFU/세포)에 형질감염시키고, 형질감염 후 표시된 시간에서 상대적 광 단위(RLU)를 측정하였다. 야생형 및 NS5△GDDAAA 레플리콘이 대조군으로 수행되었다. 모든 그래프는 평균 및 SD를 보여준다. 대표적인 실험의 경우 그룹당 n=3이고, 각 그룹 내의 시점을 4 시간에서의 RLU 값과 비교하였다. Dunnet 다중 비교 검정을 사용한 양방향 ANOVA(* = p≤ 0.05, **= p≤ 0.01, ***= p≤ 0.001, ****= p≤ 0.0001)를 수행했다.
지카 TIP 후보는 시험관내에서 야생형 바이러스를 억제한다
방법: HEK293T 세포를 증가하는 몰 비율(1:10, 1:1 또는 10:1 DVG:WT 비율)로 야생형 ZIKV 또는 후보 DVG를 암호화하는 플라스미드로 형질감염시켰다. 형질감염 4일 후, 플라크 분석에 의해 바이러스 역가를 측정하였다.
위에서 확인된 후보 TIP는 야생형 지카 바이러스를 억제하는 능력에 대해 시험관내에서 테스트되었다. 증가하는 몰비에서 각 DVG를 암호화하는 플라스미드와 함께 지카 바이러스를 암호화하는 플라스미드로 세포를 형질감염시켰다. WT 바이러스 성장에 미치는 TIP 후보의 영향은 처리 후 자손 바이러스의 양을 측정함으로싸결정하였다. 데이터(도 28)는 가장 높은 비율에서, DG-G 또는 프레임 외(out-of-frame) DG-H를 제외한 모든 TIP 후보가 최소한 약간의 억제 효과가 있는 반면, DG-C, -D, -E, -F, -K 및 -L은 바이러스 역가를 1 log 이상 저하시켰음을 보여준다. 또한, 결과는 억제의 용량 의존성을 나타낸다.
도 26: 후보 DVG에 의한 시험관내 ZIKV 복제의 억제. HEK293T 세포를 증가하는 몰비(1:10, 1:1 또는 10:1 DVG:WT)로 ZIKV 후보 DVG를 암호화하는 플라스미드 및 야생형 암호화 플라스미드로 형질감염시켰다. 형질감염 4일 후, 세포 배양 상층액을 수확하고 ZIKV 역가를 플라크 분석에 의해 특정하여 후보 DVG가 간섭 효과를 갖는지 여부를 결정하였다. Dunnet 다중 비교 검정을 이용한 양방향 ANOVA(* = p≤0.05, ** p≤0.01, *** p≤0.001, **** p≤0.0001)를 수행했다. 각 조건은 야생형 바이러스에만 형질감염된 세포와 비교하였다.
지카 TIP 후보는 생체내에서 야생형 바이러스를 억제한다.
마우스에서의 방법: AG129 수컷 마우스(4 내지 6주령)를 104 PFU의 지카 바이러스로 감염시키고, 생체내-jetPEI 형질감염 시약(Polyplus)을 사용하여 발바닥 주사(s.c.)를 통해 총 부피 50 ㎕로 DG-E, -H 또는 -K를 암호화하는 20 ㎍ 플라스미드(시험관내에서 가장 높은 억제 효과를 보인 후보 DVG)로 공동 형질감염시켰다. 대조군 마우스는 TIP를 암호화하지 않는 대조군 플라스미드를 투여 받았다. 감염을 약화시키는 TIP의 능력은 체중 감소를 통해 모니터링하였다. 바이러스혈증(Viremia)도 매일 측정하였다(5일째는 제외). 감염 7일 후, 마우스를 안락사시키고 비장 및 뇌를 이들 장기의 바이러스 역가를 측정하기 위해 해부하여 시험하였다.
결과는 3가지 TIP 모두가 체중 감소로부터 마우스를 보호한 반면, 대조군 플라스미드를 투여받은 마우스는 7일까지 유의한 체중 감소가 있었다는 것을 보여준(도 28A). 본 발명자들은 바이러스혈증에 대한 TIP 처리의 효과를 모니터링했다(도 28B). 데이터는 대조군 플라스미드를 투여받은 3마리의 마우스 모두 감염 후 2일째부터 혈액 내에 높은 수준의 바이러스를 가지고 있음을 보여준다. DG-E 또는 DG-H를 투여받은 마우스 3마리 중 2마리는 바이러스혈증이 없었고, 각 그룹의 마우스 1마리는 바이러스혈증이 1 내지 2일 지연되었다. DG-K를 투여받은 마우스는 바이러스혈증이 전혀 없었다. 그런 다음, 본 발명자들은 7일째에 마우스의 뇌, 고환 및 비장에서 바이러스 역가를 측정했다(도 28C). 대조군 처리를 받은 모든 마우스는 각 장기에서 매우 높은 역가를 나타냈다. 도 33B에서 지연된 바이러스혈증을 나타낸 마우스는 뇌에서 감소된 역가를 보였고 다른 장기에서는 유사한 역가를 나타냈다. 다른 모든 마우스는 어떤 조직에서도 검출가능한 바이러스 없이 완전히 보호되었다.
도 28: ZIKV 후보 DVG -E, -H 및 -K는 ZIKV 감염으로부터 AG129 마우스를 보호한다. AG129 마우스(수컷, 5 내지 6주령)에 형질감염 믹스 중의 20 ㎍의 DVG-암호화 플라스미드(또는 모의(mock) 플라스미드 대조군)와 104 PFU의 ZIKV의 혼합물을 주사했다. (A) 체중 감소를 매일 모니터링했다. 모의(mock) 플라스미드로 형질감염된 마우스만이 7일까지 체중이 감소했다. (B) 바이러스혈증을 매일 측정하였다. 모의 플라스미드로 형질감염된 마우스는 유사한 바이러스혈증 프로파일을 나타내었지만, 3마리 중 1마리만이 DVG-E 및 DVG-H에 대해 지연된 바이러스혈증을 나타냈다. 다른 모든 마우스(DG K로 형질감염된 마우스 포함)는 어느 시점에서도 바이러스혈증을 나타내지 않았다. (C) 7일째 오후에 마우스를 안락사시키고 뇌, 고환 및 비장을 수집하였다. 감염성 바이러스는 바이러스혈증을 나타내는 마우스에서만 검출되었다.
VLP 패키징 방법: 24-웰 플레이트에 있는 감염되지 않거나 감염된 Vero 세포(생산 세포, 24시간에서 MOI 1 PFU/세포)에 100 ng의 DVG 레플리콘 RNA, WT 레플리콘(양성 대조군) 또는 비활성 레플리콘(음성 대조군)을 TransIT-mRNA 형질감염 시약(Mirus Bio사)을 사용하여 형질감염시켰다. 형질감염 48시간 후, 상층액을 엔도뉴클레아제(25 Units/㎕ BaseMuncher, Expedeon)로 처리하고 이를 사용하여 24웰 플레이트에서 무경험 세포(수용 세포)를 감염시켰다. 수용 세포의 레플리콘 활성을 감염후 24시간에서 평가했다. 공여 및 수용 세포를 수동 용해 완충액(Promega사)에 용해시키고 루시퍼라제 활성을 Tecan infinite M200 pro 플레이트 판독기(Tecan group사)에서 Nano-Glo 루시퍼라제 분석 시스템(Promega사)을 사용하여 측정했다. 24웰 플레이트에 접종된 HEK-293T 세포를 200 ng의 CPrME 암호화 플라스미드, 200 ng의 E30-NS1 및 200 ng의 DVG 암호화 플라스미드(LT-1 형질감염 시약, Mirus Bio사)의 혼합물로 형질감염시켰다. 형질감염 72 시간 후, 배지를 원심분리에 의해 정화하였다. N개의 무경험 수용 세포를 엔도뉴클레아제(Basemuncher, Expedeon) 처리 후 생산 세포 상층액으로 감염시켰으며, 성공적인 패키징을 리포터 DVG 클론을 사용하는 경우 루시퍼라제 측정으로 확인되거나, 천연 DVG를 사용하는 경우 RT-qPCR에 의해 확인하였다.
마우스에서 VLP-DVG의 방법: 4-6주령 AG129 또는 C57BL/6 암컷 마우스에 케타민(10mg/mL)/자일라진(1mg/mL)의 혼합물을 복강내 주사로 투여했다. 마취된 후, 마우스에게 비히클(DMEM 배지), 104 PFU의 지카 바이러스 단독 또는 이를 DVG-함유 VLP(TIP)와 함께 피하(발바닥) 경로로 접종하였다. C57BL/6 마우스를 감염 하루 전에 복강내 주사에 의해 2 mg의 IFNAR1 블로킹 마우스 MAb(MAR-5A3, Euromedex)로 처리하였다. 감염 후 지정된 시간에 체중 감소 및 바이러스혈증을 모니터링했다. Microtainer 혈액 수집 튜브(BD) 내의 안면 정맥으로부터 혈액을 수집하고 실온에서 응고시켰다. 혈청을 원심분리에 의해 분리하고 -80℃에서 보관하였다. 바이러스혈증은 이전에 설명된 바와 같이19, 추출되지 않고 희석된 혈청 샘플에 대한 플라크 분석 또는 RT-qPCR에 의해 정량화하였다. 감염된 마우스를 경추 탈구로 안락사시켰다. 비장, 난소, 뇌 및 주사된 발바닥을 20초의 2 사이클 동안 5000 rpm에서 Precellys 24 균질화기(Bertin Technologies사)를 사용하여 세라믹 비드가 포함된 Precellys 튜브에서 2% FBS가 첨가된 600 ㎕ DMEM으로 균질화했다. 균질물을 원심분리에 의해 제거하고 상층액을 바이러스 적정 또는 RT-qPCR 때까지 -80℃에서 보관하였다. 장기의 바이러스 부담(burden)은 Direct-zol-96(Zymo사)을 사용한 RNA 추출 후 플라크 분석(장기의 경우 PFU/g로 표시) 또는 RT-qPCR(GAPDH에 대한 PFU 당량으로 표시)에 의해 측정하였다. 마우스 장기에서의 DVG 또는 WT RNA 게놈의 수는 마우스 GAPDH 프라이머(보충 표 1) 및 감염되지 않은 마우스의 각 장기로부터 추출한 RNA를 사용하여 표준 곡선으로부터 유도한 GAPDH 게놈에 정규화하였다.
도 29. DVG-A 운반 바이러스 유사 입자의 생성. (a) WT 바이러스에 의한 DVG-A 패키징 능력의 평가. 감염되거나 감염되지 않은 세포를 WT 레플리콘, 비활성 레플리콘, DVG-A 리포터 또는 DVG-A 프레임 외 리포터 RNA로 형질감염시켰다. 형질감염 48시간 후, 세포 상층액을 공여 세포로부터 수집하고, 네이키드 RNA를 고갈시키고, 이를 이용하여 무경험 수용 세포를 감염시키고, 24 시간 후 세포를 리포터 활성을 측정하기 위해 수확하였다. 수용 세포에서의 루시퍼라제 활성이 도시되어 있다. ****= p≤0.0001(감염되지 않은 세포와 비교하여, Dunnet 다중 비교를 사용한 양방향 ANOVA에 의함). (b) VLP 분석의 개략도: HEK-293T 세포를 CPrME, E30-NS1 및 DVG-암호화 플라스미드로 형질감염시켰다. 형질감염 후 72시간에, VLP를 함유하는 DVG가 있는 세포 배양 상청액을 수확하였다. (c) WT 레플리콘 및 DVG-A 리포터를 사용한 VLP 분석. 공여 세포를 CPrME 및 E30-NS1이 있거나 없는(모의) WT 레플리콘 또는 DVG-A 리포터 플라스미드로 형질감염시켰다. 세포 배양 상층액을 뉴클레아제로 처리하고 이를 이용하여 미경험 수용 세포를 감염시켰다. 수용 세포에서의 리포터 활성이 도시되어 있다. ****= p≤0.0001(모의 조건과 비교하여 Dunnet 다중 비교를 사용한 양방향 ANOVA에 의함). (d) 천연 DVG-A를 사용하여 생성된 VLP에서 DVG-A 게놈의 정량화. 공여 세포 유래의 정화 및 뉴클레아제 처리 상층액을 RT893 qPCR을 사용하여 DVG-A 정량화했다. 음성 대조군은 CPrME 또는 E30-NS1이 없는 상태에서 동일한 양의 DVG-A-함유 플라스미드로 형질감염된 세포에서 유래 상층액을 의미한다. ***: p= 0.0004(양측 t-검정에 의함). 모든 그래프는 평균 및 SD를 보여준다. 3개의 대표적인 실험의 그룹당 n=3.
도 30. 패키징 분석의 생산 세포에서 리포터 활성. (a) 감염되거나 감염되지 않은 Vero 세포를 WT 레플리콘, 비활성 레플리콘, DVG-A 리포터 또는 DVG-A 프레임 외 리포터 RNA로 형질감염시켰다. 형질감염 48시간 후, 세포 상층액을 생산 세포로부터 수집하고, 네이키드 RNA를 고갈시키고, 이를 이용하여 무경험 수용 세포를 감염시켰다(도 4a 참조). 생산 세포에서의 리포터 활성이 도시되어 있다. ***: p= 0.0004, ****= p≤0.0001(감염되지 않은 세포와 비교하여 Dunnet 다중 비교를 사용한 2-1011 방식 ANOVA에 의함). (b) WT 및 DVG-A 리포터를 사용한 VLP 분석. 공여 세포를 CPrME 및 E30-NS1이 있거나 없는(모의) WT 또는 DVG-A 리포터로 형질감염시켰다. 세포 배양 상층액을 뉴클레아제로 처리하고 이를 이용하여 무경험 세포를 감염시켰다. 생산 세포에서의 레플리콘 활성(감염후 72 시간)이 도시되어 있다. ****= p≤0.0001(모의 조건과 비교하여 Dunnet 다중 비교를 사용한 양방향 ANOVA에 의함). 모든 그래프는 평균과 SD를 보여준다. 3개의 대표적인 실험에 대해 그룹당 n=3.
DVG-A는 생체내 전달을 위해 바이러스 유사 입자(VLP)에 패키징될 수 있다. DVG를 잠재적 치료제로 고려하기 위해서는 적절한 전달 방법이 필요할 수 있다. 따라서, 본 발명자들은 DVG를 바이러스 유사 입자(VLP)에 캡슐화하는 패키징 시스템을 제작했다. 본 발명자들은 먼저 이러한 DVG가 캡슐화될 수 있는지 확인해야 했다. 이를 위해 본 발명자들은 감염되지 않았거나 감염된 세포를 DVG-A 리포터 또는 대조군 WT 레플리콘 RNA로 형질감염시켰다. '생산' 세포로 명명된 이 세포는 (감염된 경우) WT 바이러스 자손 및 패키징될 수 있는 게놈을 포함하는 비리온을 생산해야 한다. 감염된 생산 세포에서 유래한 상층액을 무경험(수용) 세포로 옮기면, 리포터 발현 게놈의 패키징을 평가할 수 있었다. 바이러스의 존재하의 배경 활성과 비교하여 유의하게 더 높은 WT 레플리콘 및 DVG-A 리포터 활성이 WT 바이러스의 존재하에 수용 세포에서 관찰되었으며, 이는 DVG-A가 WT 바이러스에 의해 패키징되었음을 확인시켜준다(도 29a, 생산 세포 리포터 활성은 도 30a에 도시되어 있다). 상대적으로, 비활성 레플리콘 또는 프레임 외 DVG-A의 경우에는 리포터 활성의 증가가 검출되지 않았으며, 이는 복제가 게놈 패키징을 위한 요건임을 시사한다. 다음으로 본 발명자들은 WT 바이러스의 부재하에서 DVG-A를 캡슐화하는 VLP 생성 시스템을 개발했다. 간략히 말해서, 본 발명자들은 DVG-A의 패키징 및 복제를 각각 가능하게 하기 위해 DVG-A, 구조 단백질(CPrME) 및 비구조 단백질 NS1을 암호화하는 플라스미드로 세포를 형질감염시켰다(도 29b). DVG-A의 VLP로의 패키징은 상층액을 무경험 수용 세포로 옮긴 후 평가하였다. 리포터 DVG-A를 사용하여, 본 발명자들은 패키징된 DVG-A에 대한 수용 세포의 리포터 활성은 패키징된 WT 레플리콘의 리포터 활성과 유사함을 확인했다(도 4c, 생산 세포 리포터 활성은 도 30b에 도시되어 있음). 마지막으로, 본 발명자들은 형질감염된 세포 상층액의 RT-qPCR에 의해 확인된 바와 같이, 천연 DVG-A가 VLP에 패키징되었음을 확인하였다(도 29d). 따라서, DVG-A는 생체내 평가를 위한 치료적 간섭 입자(TIP)의 역할을 할 수 있는 VLP에 적극적으로 패키징될 수 있다.
도 31. 지카 바이러스 DVG-A-보유 TIP는 마우스에서 바이러스 복제를 억제한다. (a) 실험의 설계. 4-6주령 AG129 또는 C57BL/6 암컷 마우스(n=5)를 DMEM에 희석된 WT 바이러스, 모의 TIP 상층액(구조 단백질 없이 수행된 형질감염 유래) 또는 DVG-패키징 VLP(TIP)를 함유하는 것으로 확인된 상청액에 감염시켰다. C57BL/6 마우스를 감염 24시간 전에 IFNAR1-차단 단일클론 항체 2 mg으로 처리하였다. 감염 후 여러 시간에서 혈청을 수집했다. 감염 후 6일에 마우스를 안락사시키고 장기를 적출하였다. (b-e) AG129 마우스: (b) 감염된 마우스의 체중 감소는 0일째에 체중의 %로 표시되어 있다. **:p= 0.011; ****: p≤0.0001. (c) 감염 후 2일, 4일 및 6일에서 바이러스혈증. ***: p= 0.0007; ****= p≤0.0001. (d) 주사된 발바닥, 감염 후 6일에서 비장, 난소 및 뇌의 바이러스 부하, ****= p≤0.0001. (e) RT-qPCR에 의해 측정된 수집된 모든 장기의 DVG 양. (f-h) 감염 24시간 전에 IFNAR1-블로킹 단일클론 항체를 투여한 C57BL/6 암컷 마우스. (f) 감염 후 3일 및 6일에, 바이러스혈증을 RT-qPCR에 의해 측정하였으며 PFU 당량/mL로 표시되어 있다. ****= p≤0.0001. (g) 감염후 6일에, 마우스를 안락사시키고 장기 내의 바이러스 부하를 RT-qPCR에 의해 측정했다. ****= p≤0.0001. (h) RT qPCR로 측정한 모든 장기의 DVG-A 양. 모든 경우에, Dunnet 다중 비교를 사용한 양방향 ANOVA를, 각 조건을 WT 바이러스에만 감염된 마우스와 비교함으로써 수행했다.
지카 바이러스 VLP-DVG는 마우스에서 감염 및 병독성을 감소시킨다. 다음으로 본 발명자들은 마우스에서 항바이러스 측정으로서 VLP로 패키징된 이러한 DVG의 효능을 평가했다. 본 발명자들은 α/β 및 γ 수용체가 결핍된 마우스(AG129 마우스)를 사용하였는데, 이들 마우스는 지카 바이러스 감염 및 질병 진행에 매우 취약하기 때문이다. 마우스를 모의 감염(비이클 단독)시키거나, 104 PFU의 WT 바이러스 단독으로 감염시키거나 또는 WT 바이러스와 DVG-A의 혼합물로 감염시켰다. 지카 바이러스 감염성 비리온당 대략 10개의 DVG-A 게놈 카피를 사용하였다. 추가 대조군으로서, 마우스에는 모의 생산 조건 유래의 상층액(CPrME 또는 NS1의 부재 하에 생성'대조군 TIP')와 WT 바이러스의 혼합물을 투여했다(도 31a). 모의 감염된 마우스를 제외한 모든 마우스는 6일째까지 체중이 감소했다. 이때, TIP 처리된(TIP 처리된 대조군은 아님) 마우스는 WT 바이러스에 감염된 마우스보다 유의하게 낮은 체중 감소를 나타냈다(도 31b). 또한, WT 바이러스 단독을 투여받거나 또는 대조군 처리를 받은 마우스와 달리, TIP 처리된 마우스는 감염후 2, 4 및 6일에서 바이러스 역가의 최대 2-log 차이와 함께 유의하게 더 낮은 바이러스혈증을 나타냈다(도 31c). 또한, 발바닥, 비장, 난소 및 뇌의 바이러스 부하도 6일째에 TIP 처리된 마우스에서 1 내지 2 log 더 낮았으며, 이는 이러한 TIP의 보호 효과를 강조한다(도 31d). 순환 혈액 내 DVG-A RNA가 검출 수준 미만인 반면, 본 발명자들은 TIP 처리된 마우스의 발바닥에는 DVG-A RNA가 존재하고 비장, 난소 및 뇌에서는 더 적은 양으로 존재함을 확인했다(도 31e). 이러한 결과는 DVG-A TIP가 주사 부위에서 말단 장기로 성공적으로 전파되었음을 확인시켜 준다. 추가의 뒷받침으로서, 본 발명자들은 면역학적으로 유능한(competent) 마우스 모델에서 TIP 효능을 평가했다. C57BL/6 마우스를 TIP 유무에 관계없이 지카 바이러스에 감염되기 전에 IFNAR1-블로킹 단일클론 항체로 처리하였다. 마우스는 이러한 조건에서 체중이 감소하거나 감염에 굴복하지 않기 때문에 체중 감소는 모니터링하지 않았다. 바이러스혈증은 감염 후 3일 및 6일에서 DVG 처리된 마우스에서 유의하게 낮았다(도 31f). 본 발명자들은 발바닥이나 비장에서 바이러스 부하의 차이를 관찰하지 않았지만, 난소와 뇌의 바이러스 부하가 대조군 조건과 비교하여 TIP 처리된 마우스에서 유의하게 낮았으며 바이러스 부하에서 최대 2-log 차이가 있었다(도 31g). AG129 마우스에서 언급된 바와 같이, 주사 부위에서 다량의 DVG-A가 TIP-처리된 마우스의 비장, 뇌 및 난소로 전파되었다(도 31h).
모기에서의 방법: 이집트숲모기에 Cellfectin 형질감염 시약(대조군 RNA, DG H 또는 DG K)을 사용하여 0.02 pmole RNA를 주입했다. 주입후 2일에, 모기에게 7x105 pfu/mL ZIKV를 함유한 혈분을 공급했다. 감염을 약화시키는 TIP의 능력은 감염 후 8일 또는 13일에 모기 몸통 부위의 해부 및 바이러스 부하 측정을 통해 모니터링하였다. 감염후 13일에, 모기는 또한 TIP의 존재하에서 전염을 차단할 수 있는지 여부를 조사하기 위해 침을 흘리게 했다.
결과는 감염후 13일에 모기의 전신에서, DG H 및 DG K를 주입한 모기에서 바이러스 부하가 크게 감소했음을 나타내며, 이는 TIP의 존재하에서 모기에서 바이러스 약독화를 시사한다(도 32A). 감염후 8일에서 전체 감염율은 대조군, DG H 또는 DG K-주사 모기에서는 영향을 받지 않았은 반면에, 사체에서의 유병률은 유의하게 영향을 받았는데(도 32B), 이는 DG가 모기에서 바이러스 전파를 약화시킨다는 것을 시사한다. 또한, 중장(midgut) 역가는 모든 조건의 경우에 유사했지만, 사체에서 양성인 유일한 양성 모기는 대조군 RNA-주입 모기에서보다 더 낮은 역가에 도달했다(도 32C). 마지막으로, 감염 후 13일에, 대조군 RNA가 주입된 모기 9마리 중 7마리는 침에서 ZIKV 양성인 반면(따라서 잠재적으로 바이러스를 전염시킬 수 있음), 침은 DG H에 대해 양성이 아니었으며(n=13) 16마리 중 1마리는 DG K 주입 모기에 대해 양성이었다(도 32 D).
도 32: ZIKV DG H 및 K는 실험적으로 감염된 모기에서 바이러스 복제, 전파 및 전염을 억제한다. 이집트숲모기에 0.02 pmole RNA를 주입했다. 주입 2일 후, 모기에 7x105 pfu/mL ZIKV를 함유한 혈분을 공급하고 주입후 8 또는 13일에 해부했다. (A) 주입후 13일에 대조군(n=8), 프레임 외 DG(n=11) 또는 프레임 내 DG(n=10) RNA가 미리 주입된 모기 전신의 바이러스 부하. (B) 감염후 8일에 대조군(n=6), 프레임 외 DG(n=10) 또는 프레임 내 DG(n=10)가 미리 주입된 모기의 중장 또는 사체에서 ZIKV 감염의 유병률. (C) (B) 유래의 동일한 모기의 중장 또는 시체의 바이러스 부하. (D) 주입후 13일에 대조군(n=9), 프레임 외 DG(n=13) 또는 프레임 내 DG(n=16)가 미리 주입된 모기의 ZIKV-양성 타액의 백분율. 프레임 외 DG = DG H; 프레임 내 DG = DG K.
확인된 ZIKV 서열은 도 40에 나열되어 있다.
ZIKV DVG 서열은: 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K) 및 서열 번호: 33 (ZIKV DVG-L)로 이루어지는 군으로부터 선택된다.
바람직한 ZIKV DVG 서열은: 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 24 (ZIKV DVG-C) 및 서열 번호: 25 (ZIKV DVG-D)로 이루어지는 군으로부터 선택된다.
가장 바람직한 ZIKV DVG 서열은 서열 번호: 26(ZIKV DVG-E), 서열 번호: 32(ZIKV DVG-K), 서열 번호: 33(ZIKV DVG-L) 및 하기의 특성을 갖는 클러스터 내의 다른 가능한 DVG로 이루어진 군에서 선택된다; 결실은, 시작 부위가 위치 500과 900 뉴클레오티드 사이에 있고 결실의 중지 부위가 ZIKV 게놈의 위치 2800과 3400 뉴클레오티드 사이에 있는 프레임 내 결실 이벤트를 초래한다.
실시예 4: 치쿤구니야 바이러스(CHIKV)
본 실시예에서, 본 발명자들은 시험관내 및 생체내에서 치쿤구니야 바이러스 감염 동안에 발생하는 결실을 포함하는 자연 발생 DVG를 문서화하고 특성규명한다. 이들 중에서, 본 발명자들은 복제물 사이의 빈도 및 재발 및/또는 여러 계대에 걸쳐 전달되는 그의 능력에 기반하여 간섭 능력을 가질 가능성이 가장 큰 DVG를 선택했다. 본 발명자들은 천연 DVG가 시험관내에서 포유류 및 모기 세포 모두에서 치쿤구니야 바이러스에 강력한 항바이러스 활성을 가지고 있음을 밝히고, 간섭 DVG가 다른 알파 바이러스에 대한 광범위 스펙트럼 억제제가 될 수 있음을 설명한다. 마지막으로, 본 발명자들은 아르보바이러스 전파를 억제하기 위해 감염 전에 DVG가 모기 벡터에 도입될 수 있음을 보여준다.
Vero, Huh7, 293T 및 BHK 세포는 37℃, 5% CO2의 가습 분위기에서 10% 우태아 혈청(FCS), 1% 페니실린/스트렙토마이신(P/S; Thermo Fisher사) 및 1% 비필수 아미노산(Thermo Fisher사)을 포함하는 Dulbecco's modified Eagle's medium (DMEM)Dulbecco의 변형된 Eagle 배지(DMEM)에서 성장시켰다. U4.4 및 Aag2 세포는 28℃에서 10% FCS, 1% P/S, 1% 비필수 아미노산(Sigma사) 및 1% 트립토오스 포스페이트(Sigma사)를 포함하는 Leibovitz's L-15 배지에서 유지하였다.
바이러스 스톡을 인도양 계통, ECSA 유전자형(IOL, 17에 설명) 또는 카리브해 균주, 아시아 유전자형(Carib, 18에 설명)에서 유래된 CHIKV 감염성 클론으로부터 생성하였다. DVG 간섭 활성을 테스트하기 위해, 서브게놈 프로모터 하에 가우시아(Gaussia) 루시퍼라제 유전자를 포함하는 CHIKV 감염성 클론을 사용했다(Andres Merits사에서 얻음). SP6 mMESSAGE mMACHINE 키트(Invitrogen사)를 사용한 시험관내 전사(IVT)를 lipofectamine 2000(Invitrogen사)을 사용하여 BHK에 형질감염시키기 전에 NotI 선형 플라스미드를 이용하여 수행했다. Vero 세포에서 1회 계대한 후, 스톡을 적정하고 사용 전에 -80℃에서 유지하였다.
바이러스 적정은 감염 24시간 전에, 24웰 플레이트에 플레이팅된 컨플루언트 Vero 세포에서 수행하였다. DMEM 단독으로 10배 희석을 수행하고 Vero 세포에 옮겼다. 감염을 가능하게 한 후, 2% FCS, 1% P/S 및 0.8% 아가로스를 포함하는 DMEM을 세포 위에 추가했다. 감염 3일 후, 세포를 4% 포르말린(Sigma사)으로 고정하고, 0.2% 크리스탈 바이올렛(Sigma)으로 염색한 후 플라크를 수동으로 계수했다.
세포를 24-웰 플레이트에 접종하여 다음날 대략 80% 컨플루언시(confluency)에 도달하도록 하였다. 계대 1의 경우, 바이러스를 PBS에 희석하여 5 PFU/세포(높은 MOI)의 감염 다중도(MOI)를 얻었다. 세포를 바이러스 접종물과 함께 37℃에서 1시간 동안 인큐베이션하였다. 바이러스 흡착 후, 접종물을 제거하고, 감염된 세포를 PBS로 세척하고, 2%(v/v) FCS를 함유하는 적절한 세포 배양 배지로 교체하였다. 감염 후 48 내지 72시간에서, 상층액을 수확하고 원심분리(12,000 x g, 5분)에 의해 정화하였다. 이후의 계대는 블라인드로 수행되었으며, 이전 계대 유래의 정제된 상층액의 고용량(300 ㎕)을 사용하여 무경험 세포를 감염시킨 후 동일한 절차를 수행했다. 총 10회의 계대를 수행하였다. 각 계대를 플라크 분석으로 적정하여, DVG 축적이 간섭을 초래할 수 있는 계대를 결정했다. 세포 유형당 최소 3번의 복제를 수행했다.
시퀀싱. 제조사의 프로토콜에 따라 TRIzol 시약(Invitrogen사) 또는 ZR 바이러스 RNA 키트(Zymo사)를 사용하여 각 샘플 상층액 100 ㎕의 RNA를 추출했다. RNA를 15 내지 30 ㎕의 뉴클레아제가 없는 물에 용출시켰다. Quant-iT RNA 분석 키트(Thermo Fisher Scientific사)를 이용하여 정량한 후, NEBNext Ultra II RNA Library kit(Illumina)를 이용하여 RNA 라이브러리를 제조하였다. 멀티플렉스 올리고(Illumina사)를 라이브러리 제조 동안에 사용하였다. 라이브러리의 품질은 고민감도 DNA 칩(Agilent사)을 사용하여 확인하고 Quant-iT DNA 분삭 키트(Thermo Fisher Scientific사)를 사용하여 정량했다. 라이브러리(1 nM로 희석)의 시퀀싱은 NextSeq 500 Mid Output 키트 v2(Illumina사)를 이용하여 NextSeq 시퀀서(Illumina사)에서 수행했다(151 사이클).
차세대 시퀀싱 데이터 분석. 모든 분석은 BBTools 제품군(Bushnell B. - sourceforge.net/projects/bbmap/)을 사용하여 수행되었다. 먼저, 샘플 시퀀싱으로부터 생성된 fastq 파일을 BBDuk을 사용하여 저품질 베이스 및 어댑터에 맞게 트리밍했다. 그런 다음, BBmap 및 적절한 CHIKV 기준 서열(Carib - GenBank 수탁 번호 LN898104.1, IOL - GenBank 수탁 번호 AM258994)을 사용하여 정렬을 수행했다. BBMap의 변형 호출자(variant caller) CallVariants는 결실 이벤트를 보고했으며, 샘플당 전체 DVG 빈도는 각 DVG에 해당하는 접합 리드 수(n)의 합으로 계산되었고 5/3 Х n/N으로 정규화되었다. 여기서 N은 위치당 적용 범위의 98번째 백분위수이다. 5/3을 곱하는 것은 검출 한계를 보정하기 위한 것이다. 실제로, 리드 길이가 150개 뉴클레오티드인 경우에도, 정렬된 부분의 길이는 일반적으로 30 내지 120개뉴클레오티드에 불과하다. 이는 중단점의 상류에서 30개 이하의 뉴클레오티드를 시작하는 리드가 중단점의 오른쪽에 정렬되지만 왼쪽에는 정렬되지 않으므로 DVG로 간주되지 않음을 의미한다. 결과적으로, (30+30)/150 = 60/150 = 2/5의 결실을 놓치고 있으므로, 보정 계수로 5/3을 곱해야 한다. 히트맵은 특정 위치를 제거하는 결실 이벤트를 기반으로 하는 뉴클레오티드 위치당 결실 점수를 보여준다. 구체적으로, 점수는 특정 뉴클레오티드 위치의 결실을 뒷받침하는 백만 리드당 리드수(RPM)의 합으로 계산되었다. 시작/중지 중단점을 플로팅하기 위해, 10개 뉴클레오티드 미만의 길이를 갖는 결실은 폐기되었다.
선택된 결함이 있는 게놈의 클로닝. 이전에 설명한 In Vivo Assembly(IVA) 방법19 또는 In-Fusion 시약(Takara Bio Reagent사)을 사용하여, 계대로부터 선택된 결함이 있는 게놈을 그의 균주에 해당하는 CHIKV 감염성 클론(SP6 프로모터 아래)에 클로닝했다. 프라이머는 60℃의 용융 온도에서 SnapGene 소프트웨어를 사용하여 설계하였으며 Integrated DNA Technology(IDT)사에서 얻었다. Phusion 고충실도 DNA 중합효소(Thermo Fisher사) 또는 Q5 DNA 중합효소(NEB)를 사용하여 50 ㎕ PCR을 수행했으며 융점은 Phusion 효소의 경우 57℃ 또는 Q5 중합효소의 경우 65℃였다. 18 사이클을 수행한 후 PCR 산물을 2시간 이상 DpnI(Thermo Fisher사)로 처리하여 플라스미드 주형을 제거하고 정제했다(Macherey Nagel PCR 및 겔 정제 키트). IVA 기법을 사용하는 경우, 제공된 프로토콜에 따라 2 ㎕의 PCR 산물을 XL10-Gold 엑스트라 컴피턴트 세포(Stratagene)에 직접 형질전환했다. In-Fusion 반응이 필요한 경우, 공급업체 지침에 따라 In-Fusion 시약(Takara Bio Reagent사)을 사용하여 PCR 산물을 라이겐이션하고 1 ㎕를 Turbo 세포(NEB사)에 형질전환했다.
DG 간섭 활성을 테스트하기 위한 루시페라제 분석. IVT는 DVG 및 CHIKV Carib-GLuc의 NotI 선형화 감염성 클론으로부터 SP6 mMESSAGE mMACHINE 키트(Invitrogen사)를 사용하여 수행하였다(위 참조). RNA 생성은 Qubit RNA TS 분석 키트(Thermo Fisher사)에 의해 정량화하였고 Carib-GLuc CHIKV와 비교하여 표시된 몰비로 희석하였다. 공급자의 프로토콜(웰당 25 ng의 Carib-GLuc CHIKV)에 따라 TransIT-mRNA 형질감염 키트(Mirus)를 이용하여 혼합 DVG 및 전체 게놈 RNA를 96웰 플레이트에 접종된 293T 또는 U4.4 세포에 형질감염시켰다. 세포 독성을 피하기 위해 형질감염 4시간 후에 배지를 교체하였다. 형질감염 48시간 후, 상층액을 수집하고 최종 농도 0.05 μM에서 코엘렌테라진(Y. Janin, Institut Pasteur에 의해 제공)과 혼합하고 Tecan Infinite 200 마이크로플레이트 리더에서 발광을 측정하였다. 비-루시퍼라제 발현 바이러스로 시험한 경우, 절차는 동일한 방식을 따랐지만 상층액은 형질감염 48시간 후에 플라크 분석에 의해 적정되었다.
DVG 자가 복제를 테스트하기 위한 RT-qPCR. 50 ng의 DVG 또는 CHIKV Carib IVT를 293T 세포(48웰 플레이트에 전날 접종)에 전술한 바와 같이 3중으로 형질감염시켰다. 형질감염 8시간 후, 상층액을 제거하고, 세포를 PBS로 3회 세척한 후 신선한 배지를 첨가하였다. 형질감염 후 8, 20, 28 및 44시간에서, ZR 96 바이러스 RNA 키트(Zymo) 유래의 용해 완충액 200 ㎕를 상층액 제거 후 세포에 첨가하고 모든 시점이 수집될 때까지 -20℃에서 보관하였다. ZR 96 바이러스 RNA 키트를 이용하여 세포 RNA를 추출하고 15 ㎕로 용출시켰다. TaqMan RNA-to-Ct One-step RT-PCR 키트(Applied Biosystems사)를 사용하여 정방향 프라이머로서 5'-GAGACACACGTAGCCTACCA-3', 역방향 프라이머로서 5'-GGTTCCACCTCAAACATGGG-3' 및 프로브로서 5'- [6-FAM] ACGCACGTTGCAGGGCCTTCA-3'을 사용하여 5'UTR-nsP1 영역에 걸쳐 정량적 RT-PCR을 수행했다. 50℃에서 20분 및 95℃에서 10분 후, 40 사이클(95℃에서 15초 후 60℃에서 1분)을 수행하였다.
모기. 태국 Kamphaeng Phet 지방에서 채집한 야생모기 7세대에 속하는 이집트숲 암컷 모기를 28℃, 상대습도 70% 및 12시간 광:12시간 암의 주기에서 성장시키고 10% 자당을 급여하였다. 급여 하루 전, 6 내지 10일 된 암컷을 선발하여 하루 굶겼다. 106 PFU/ml의 CHIKV가 포함된 혈분을 탈염된 돼지 내장 조각을 막으로 하여 37℃로 설정된 막 공급 시스템(Hemotek Ltd사)을 통해 60 마리 암컷의 풀에 제공하였다. 혈분 공급 후, 완전히 울혈된 암컷을 선택하고 28℃, 70% 상대 습도 및 12시간 광: 12 시간 암의 주기 하에 10% 자당에의 영구적 접근을 허용하면서 인큐베이션하였다. 7일 후, 모기를 희생시키고 해부하여 머리, 흉부, 중장, 다리 및 날개(다리/날개) 및 복벽(몸체)을 수집하였다. 각 장기를 Qiagen TissuLyser 2 기계로 2% FBS가 첨가된 L15 300 ㎕에서 분쇄한 다음, 원심분리로 정화한 다음 적정하고 RNA 심층 시퀀싱을 위해 TriZol 시약으로 RNA를 추출했다. 시험관내 전사(위에 기재된 바와 같음)에 의해 생성되고 페놀-클로로포름으로 정제된 150 나노그램의 RNA를 공급자의 지침에 따라 Leibovitz's L-15 배지 및 Cellfectin II 시약(Thermo Fisher사)와 혼합했다. 각 조건의 경우, 이 혼합물 300 nl를 6-8일 된 암컷 40 마리에게 Nanoject III Nanoliter Injector(Drummond science company)를 이용하여 흉부 내 주사했다. 이틀 후, 밤새 굶긴 후, 모기에 위에서 설명한 대로 106 PFU/ml의 CHIKV Carib-GLuc의 감염성 혈분을 공급했다. 5일 후, 모기를 희생시켰다: 중장 및 사체를 해부하고 앞서 언급한 바와 같이 분쇄했다. 그런 다음, 각 샘플을 루시퍼라제 활성에 대해 테스트하고 플라크 분석으로 적정했다.
시험관내 높은 MOI 계대에 의한 결함이 있는 바이러스 게놈(DVG)의 생성. 세포 배양에서 발생할 수 있는 결실된 DVG를 포착하기 위해 치쿤구니야 바이러스(CHIKV Carib)의 카리브 균주를 포유동물 세포(Vero, Huh7) 및 모기(Aag2, U4.4) 세포에서 높은 MOI로 3중으로 연속 계대했다. 각 계대에서 각 복제물의 정화된 상층액으로부터 RNA를 추출하고 RNA 심층 시퀀싱을 수행했다. 결실이 포함된 시퀀스 리드를 식별하여 DVG를 설명하고 정량화하기 위해 리드를 Bbmap 파이프라인으로 분석했다. 예상대로, 첫 번째 계대와 마지막 계대 사이의 DVG의 양은 모든 세포 유형에서 1 내지 5배 정도 증가했으며 비(rate) 및 진동(oscillation)은 각 세포 유형에 따라 차이가 있었다(도 33A).
시험관내에서 생성된 DVG의 특성규명. 다음으로, 본 발명자들은 여러 세포 유형에서 잠재적인 결실 핫스팟을 식별하기 위해 모든 계대에 대한 데이터 및 각 세포 유래의 복제물을 풀링했다. 얻어지는 히트 맵(도 33B)는 각 뉴클레오티드 위치가 결실된 빈도를 나타내며(결손의 전체 길이에 관계없이), 여기서 x축은 전체 치쿤구니야 바이러스 게놈을 따른 뉴클레오티드 위치를 나타낸다. 각 행은 다른 셀 유형을 나타낸다. 본 발명자들은 세포 유형 간 결실 빈도가 더 높은 영역에서 명확한 차이를 관찰했으며, 이는 동일한 바이러스 균주가 숙주 환경에 따라 다양한 결실 변이체를 생성한다는 것을 시사한다. Vero 및 Huh7 세포에서, 결실은 비구조적 단백질 nsP1-nsP2에 걸쳐 있는 영역에서 풍부했지만, 핫스팟 프로파일은 Vero 세포에 비해 HuH7에서 더 짧았다. Aag2 세포에서, 뉴클레오타이드가 결실될 가능성은 게놈 전체에 더 널리 퍼졌다. 치쿤구니야 바이러스 게놈의 전반부에서 결실이 발생한 다른 세포주와 달리, U4.4 세포에서 생성된 DVG는 게놈의 후반부(뉴클레오티드 6000[nsP3]에서 11500[3'UTR]까지)에서 더 자주 결실을 나타냈다. 참고로, CHIKV IOL(Indian Ocean Lineage) 균주에 대한 동일한 실험은 Vero 및 Aag2 세포에서 CHIKV Carib 균주와 유사한 결실 프로파일을 보였다. 그러나, CHIKV IOL 결실은 Huh7(가장 강한 핫스팟이 뉴클레오티드 9000[E2]에서 11000[3'UTR]까지임) 및 U4.4 세포(이 경우 프로파일이 Aag2 세포에서 얻은 프로파일과 유사함)에서 크게 달랐다(도 33B). 종합하면, 이러한 결과는 바이러스 균주 및 세포 환경이 시험관내 계대 동안 DVG의 생성 및 유지에 영향을 미친다는 것을 시사한다. 이러한 바이러스 집단에서 여러 DVG를 시각화하기 위해, >100개 뉴클레오티드가 결실된 개별 DVG의 특정 시작(x축) 및 중지(y축) 중단점을 플로팅하였다(도 33C). 분석 결과, 모든 세포 유형에서 관찰된 결실의 크기 및 위치에 따라 3개의 클러스터(클러스터 A, B 및 C)를 형성하는 우세한 DVG가 확인된 반면, 모기 세포에서는 네 번째 클러스터(클러스터 D)가 더 두드러졌다. 클러스터 A는 nsP1과 nsP2 유전자 사이에서 약 2500 nt의 비교적 작은 결실을 나타냈다. 클러스터 C는 nsP2의 끝에서 3'UTR의 시작 부분까지 9000 nt 이상의 큰 결실을 나타냈고, 클러스터 B의 경우 nsP1에서 3'UTR까지에 걸쳐 더 큰 결실을 나타냈다. 이집트숲모기 세포(Aag2 및 U4.4) 및 덜하지만 포유동물 세포에서는, nsP3과 3'UTR 사이에 약 5000nt의 결실을 갖는 또 다른 클러스터 D가 존재했다.
생체내 모기에서 치쿤구니야 DVG의 생성. DVG가 생체내 모기 감염 중에도 생성되는지 확인하기 위해, 본 발명자들은 106 PFU/ml의 카리브해 변종 치쿤구니야 바이러스를 함유한 이집트숲모기에 감염된 혈분을 공급했다. 감염이 7일 동안 모기 전체에 퍼질 수 있도록 한 후, 본 발명자들은 모기 중 10 마리를 희생시키고 해부하여 중장, 복벽(몸통), 흉부, 머리 및 다리/날개와 같은 개별 장기를 수집했다(도 34A). RNA를 추출하고 시퀀싱하고 BBmap 파이프라인을 사용하여 데이터를 분석했다. DVG 시작 및 중지 위치의 플롯은 Aag2 세포(도 34C)에서 생성된 데이터와 유사한 패턴을 보여주었으며, 4개의 별개의 클러스터(도 34B)가 있었다. 10마리 중 2마리의 모기(도 34C)에서, 본 발명자들은 여러 장기(한 모기의 경우 중장, 몸통, 머리 및 다리/날개, 다른 모기의 경우 몸통과 머리)에서 동일한 DVG(CM1)를 발견했다. 다른 모기나 이 모기를 감염시키는데 사용된 바이러스 스톡은 이러한 DVG-CM1를 포함하지 않았다. 이러한 결과는 DVG가 모기 숙주에서 쉽게 생성되고 세포 배양에서 관찰된 것과 유사한 결실 프로필을 공유한다는 것을 나타낸다.
치쿤구니야 DVG 후보는 복제되지 않는다. 이전 섹션에서 본 발명자들의 목표는 바이러스 감염 동안에 생성된 가능한 모든 DVG를 찾아내고 수백 개의 개별 DVG 중에서 가장 가능성이 높고 효율적으로 야생형 바이러스와 경쟁할 수 있는 DVG를 하향 선택하는 것이었다. 즉, 전체 DVG 중 어느 것이 가장 강력한 결함이 있는 간섭 입자인지를 식별하기 위한 것이었다. 본 발명자들의 근거는 그러한 DVG가 높은 MOI 계대에서 더 자주 발생하고, DVG가 자원을 놓고 야생형 바이러스와 경쟁함에 따라 시간이 지남에 따라 더 높은 빈도로 증가한다는 것이다. 따라서 DVG는 야생형 경쟁자에 비해 더 높은 적합성을 나타내는 기준에 따라 선택되었다. 그 기준은 높은 빈도를 가지며, 계대 시리즈 전체에 걸쳐 유지되고, 여러 복제물에서 발생한다는 것이다. 뉴클레오티드 2695(nsP2의 중간)에서 뉴클레오타이드 5358(nsP3의 끝)(도 35A)까지의 결실을 지닌 DVG-CM1 외에도, 본 발명자들은 CHIKV Carib(위에서 설명된) 및 CHIKV IOL의 세포 계대 심층 시퀀싱 데이터로부터 또 다른 19개의 DVG를 선택하고 클로닝했다. 4개 클러스터 모두의 대표가 선택되었다(도 35A). 본 발명자들은 DVG를 그의 기원 바이러스 균주(CHIKV Carib의 경우 C, CHIKV IOL의 경우 I) 및 DVG가 생성된 세포(Vero의 경우 V, Huh7의 경우 H, Aag2의 경우 A 및 U4.4의 경우 U, 생체내 모기의 경우 M)에 따라 명명했다. 이들의 게놈 구성은 도 35A에 도시되고 이들의 정확한 결실은 표 1에 나열되어 있다. 3개의 추가 후보는 정의된 클러스터에 속하지 않았지만 여러 복제물에서 높은 빈도로 존재했으며 계대 전체에 걸쳐 유지되었다(표 1). 선택된 DVG가 바이러스가 없으면 자가 복제할 수 없는 결함이 있는 게놈임을 확인하기 위해, 본 발명자들은 293T 세포에 각 DVG 또는 야생형 바이러스의 시험관내 전사된 RNA를 형질감염시켰다. 본 발명자들은 형질감염 후 8, 20, 28 및 44시간에서 각각의 DVG- 또는 대조군-형질감염된 세포를 수확하고, 세포로부터 RNA를 추출하고 RT-qPCR을 수행했다. 시점 전반에 걸쳐 RNA 카피 수가 증가하는 CHIKV Carib 전장 바이러스 RNA와 달리, 모든 DVG RNA 카피 수는 시간이 지남에 따라 감소하였는데, 이는 형질감염된 RNA의 점진적인 분해를 나타내고 후보 DVG 중 어느 것도 자가 복제할 수 없음을 입증한다(도 38).
치쿤구니야 DVG는 시험관내에서 야생형 바이러스를 방해한다. 다음으로 본 발명자들은 포유류 세포에서 포유류 세포 배양물(도 39B) 또는 모기 숙주 환경(도 39C)로부터 유래된 20개의 DVG의 간섭 활성을 테스트했다. 본 발명자들은 높은 형질감염성(transfectability)을 위해 293T 세포를 선택하고, 신속한 정량화를 위한 표적 바이러스로서 서브-게놈 프로모터(CHIKV Carib-Gluc)하에서 가우시아 루시퍼라제를 발현하는 CHIKV Carib 바이러스를 선택했다. 포유동물 세포 또는 모기 세포 배양에서 유래된 DVG를 테스트하기 위해, 293T 세포에 하나의 관심 DVG(또는 대조군 RNA)에 해당하는 시험관내 전사된 RNA와 CHIKV Carib-Gluc 전장 바이러스 RNA(1:1 또는 10:1 몰비)의 혼합물을 형질감염시켰다. 역가와 발광성이 상관관계가 있기 때문에, 상층액을 48시간에서 수확하여 야생형 바이러스 복제에 대한 대리 척도로서 루시페라제 활성을 측정했다(도 39). 1:1 몰비에서, 대부분의 DVG는 야생형 바이러스 루시퍼라제 발현을 감소시키지 않았지만 IV1 및 IH1의 형질감염은 완만한 감소를 나타냈다(p<0.05). 그러나, DVG RNA의 양을 CHIKV Carib-Gluc RNA의 양의 10배로 증가시키면 거의 모든 경우에 1 내지 3배 정도 바이러스 복제가 유의하게 억제되었다(도 34B 및 도 34C). 참고로, 가장 큰 결실(클러스터 B 유래의 CH2 및 CH3)을 가진 가장 작은 DVG는 1 log 미만의 감소로, 가장 높은 DVG:CHIKV Carib-Gluc 몰비에서 간섭 활성이 없거나 거의 없었다(도 35B). 이러한 결과는 포유동물 세포 또는 모기 세포 배양물에서 유래된 DVG가 외인성으로 도입될 때 포유동물 세포에서 바이러스 복제를 억제할 수 있음을 보여준다.
이러한 포동물 세포 및 모기 세포 유래 DVG가 모기 세포에서 바이러스 복제를 억제할 수 있는지 여부를 결정하기 위해, 본 발명자들은 흰줄숲모기 세포(U4.4)에서 실험을 반복했다. 293T 세포의 경우, 1:1 몰비에서 간섭이 관찰되지 않았지만, IV4를 제외하고 이전에 포유동물 세포에서 바이러스를 억제했던 모든 DVG의 경우 10:1 비율에서 루시페라제 활성의 1 내지 2 log 감소와 함께 상당한 억제가 관찰되었다. 293T 세포에서 볼 수 있는 것처럼, 모기 세포에서 DVG CV3의 경우 간섭은 관찰되지 않았으며(p>0,05)(도 35D), CH3와 함께 DVG CV3는 어떤 조건에서도 바이러스를 억제하는데 실패한 20개의 DVG 후보 중 단 2개였다. 반면에, 293T 세포에서 바이러스를 억제할 수 있었던 대부분의 모기 세포 유래 DVG는 모기 세포에서 간섭 활성을 완전히 잃었는데, DVG CA2, CA3 및 CM1만이 10:1의 몰비에서 U4.4 세포에서 루시퍼라제 활성을 1 내지 2 log로 유의하게 감소시켰다(도 35E).
치쿤구니야 DVG는 광범위한 억제제가 될 수 있다. 치쿤구니야 바이러스 인도양 계통은 동부, 남부 및 중앙 아프리카(ECSA) 유전자형에 속하며 아시아 유전자형에 속하는 치쿤구니야 바이러스 카리브 균주와 약 7%의 뉴클레오티드 분기(divergence)를 갖는다20. 이전 실험에서, 인도양 계통 또는 카리브해 균주에서 유래된 DVG를 가우시아 루시페라제를 발현하는 카리브해 균주 바이러스에 대해 테스트하였다. 중요하게도, 모든 CHIKV IOL 유래 DVG는 카리브해 균주를 억제하였는데, 이는 DVG가 동일한 바이러스 종 내에서 광범위하게 작용할 수 있음을 보여준다(도 35B, 35C, 35D 및 35E). 이러한 결과를 확장하기 위해, 본 발명자들은 CHIKV IOL 균주를 표적 바이러스로 사용하여 293T에서 동일한 실험을 반복했다. 이 경우, 본 발명자들은 발광 대신 바이러스 역가에 의해 억제를 측정했다. 대부분의 DVG는 포유동물(도 36A) 또는 모기(도 36B) 환경에서 확인되었는지 여부에 상관없이 바이러스 역가를 약간 또는 상당히 감소시켰다.
다음으로 본 발명자들은 CHIKV DVG가 알파바이러스 속 내에서 훨씬 더 광범위하게 억제할 수 있는지 여부를 조사했다. 본 발명자들은 오니옹니옹(O'nyong'nyong) 바이러스(ONNV, CHIKV의 가장 가까운 친척) 또는 신드비스(Sindbis) 바이러스(SINV, 매우 먼 친척)를 표적으로 하여 293T 세포에서 동일한 실험을 수행했다. 대부분의 DVG에서 억제 효과가 상실되었지만 몇몇 DVG는 여전히 오니옹니옹 바이러스(CV2 및 CH1)를 유의하게 억제했다(도 36C). 모기 유래 DVG 중 CM1은 오니옹니옹 바이러스 역가가 거의 검출되지 않고 억제 활성을 유지했다(도 36D). 관계가 먼 신드비스 바이러스에 대해 테스트했을 때, 간섭 활성은 모든 DVG의 경우에 상실되었지만, CM1의 경우는 신드비스 바이러스를 2 log 만큼 억제했다(도 36E, 도36F). 이러한 결과는 하나의 알파바이러스에서 유래된 몇몇 DVG가 동일한 속 유래의 관계가 밀접한, 어떤 경우에는 관계가 더 먼 바이러스를 포함하는 다른 균주에 대해 억제 활성을 가질 수 있음을 확인시켜 준다.
치쿤구니야 DVG는 이집트숲모기에서 생체내 바이러스 전파를 차단한다. DVG가 시험관내 감염을 제한/억제하는데 사용될 수 있음을 입증한 후, 본 발명자들은 간섭 활성이 모기 숙주의 감염 또는 전파를 차단하는데 사용될 수 있는지 여부를 테스트했다. 이를 위하여, 본 발명자들은 CHIKV Carib-Gluc 바이러스가 포함된 혈분을 공급하기 2일 전에 CV4, IH1 또는 CM1 DVG, 대조군 RNA 또는 PBS의 정제된 RNA를 이집트숲모기에 주입했다. 감염 5일 후, 모기를 죽이고 나머지 사체에서 중장을 절개했다(도 37A). 루시페라제 활성을 정량화하여 각 모기에서 바이러스 복제를 측정하였다. 중장에서의 복제는 간섭 DVG 후보가 존재하는지 여부에 관계없이 모든 모기에서 유사했다. 그러나, CV4- 및 CM1-처리된 모기 사체에서는 복제가 크게 감소했다(도 37B). 그런 다음, 중장(감염을 나타냄) 및 사체(바이러스 전파에 대한 대용물(proxy)) 내의 바이러스를 정량화하고 감염성 바이러스의 검출 여부에 따라 양성 또는 음성으로 분류했다(검출 한계는 장기당 30 PFU). 모든 그룹은 유사한 비율의 양성 중장(81 내지 91.7%)을 가졌으며(도 37C), 이는 혈분 공급 후 감염된 모기의 수가 각 그룹에서 유사함을 확인시켜 준다. 반면에, 바이러스 전파는 DVG의 존재에 의해 크게 영향을 받았다. CV4, IH1 또는 CM1 DVG를 주입한 모기는 PBS를 주입한 모기에 비해 전파율이 낮았다(각 그룹에서 총 감염된 모기 수의 16.7%, 47.6% 및 41.7%)(도 37C). 이러한 결과는 DVG가 모기 숙주에서 생체내 바이러스 복제 및 전파에 영향을 줄 수 있음을 확인시켜 준다.
도 33: 시험관내 다양한 숙주에서 치쿤구니야 바이러스(CHIKV) 결함 바이러스 게놈(DVG)의 생성. CHIKV의 카리브해 균주(Carib) 및 인도양 계통(IOL)을 모기(U4.4, Aag2) 또는 포유동물(Vero, Huh7) 세포에서 높은 MOI로 세 번 계대하였다. 각 계대에 대해, 이전 계대에서 수확한 상층액을 사용하여 신선한 세포를 감염시켰다. 감염은 48 내지 72시간 지속되었다. (A) 계대를 통한 DVG 축적. 각 샘플의 RNA 심층 시퀀싱 및 Bbmap 파이프라인 출력으로 DVG의 정량화 후에 결정된, 2개의 포유동물 세포주(Vero, Huh7) 및 2개의 모기 세포주(Aag2, U4.4)에서 각 복제에서 발생하는 CHIKV Carib DVG의 총 빈도. 적용범위(coverage)가 200 미만인 샘플은 분석에서 제외되었다. DVG 수는 각 계대(x축)에서 로그 스케일(y축)로 표시되어 있다. (B) 다양한 세포 유형에서 CHIKV Carib 또는 IOL DVG 히트 맵. 각 계대의 바이러스 집단을 딥 시퀀싱(RNAseq)하였고 BBmap 파이프라인을 통해 분석하였다. 전체 게놈 전체에 걸쳐 각각의 결실된 뉴클레오티드 위치(x축)의 정규화된 빈도의 모든 계대 및 복제의 평균은 각각의 다른 세포 유형(y축)에 대한 히트 맵(주황색 음영)으로 표시되어 있다. (C) CHIKV Carib에 의한 높은 MOI 계대에 의해 생성된 결실의 분석. 생성된 DVG의 중단점의 시작(x축) 및 중지(y축) 위치는 각 세포 유형에 대해 플롯되어 있다. 서로 다른 클러스터를 A, B, C, D로 명명한다.
도 34: 생체내 모기에서 치쿤구니야 DVG의 생성. (A) 타이 이집트숲모기(Thai Aedes aegypti)에게 106 PFU/ml의 CHIKV Carib에 감염된 혈분을 공급했다. 7일 후, 모기 10마리를 희생시키고 중장, 복벽(몸체), 흉부, 머리 및 다리/날개를 해부하였다. 적정에 의한 감염 확인 후, 바이러스 RNA를 추출하고 딥 시퀀싱했다. (B) 9마리의 감염된 모기에서 CHIKV Carib에 의해 생성된 결실의 분석. 생성된 DVG의 중단점의 시작(x축) 및 중지(y축) 위치가 각 장기에 대해 플롯되어 있다. (C) 2마리의 개별 모기의 여러 장기에서 생성된 DVG의 중단점의 시작(x축) 및 중지(y축) 위치. 빨간색 점은 2695에서 시작하여 5358에서 끝나는 결실을 나타내며 이 DVG를 CM1이라고 명명한다. 그 옆에 있는 숫자는 100만 리드당 리드 수(RPM)를 나타낸다.
도 35: 결함이 있는 바이러스 게놈은 치쿤구니야 바이러스 복제를 방해할 수 있다. (A) DVG 후보 및 이들이 유래된 세포 유형 및 균주(C Carib, I IOL)의 개략도. (B-E) 시험관내 DVG 활성의 측정. 포유동물 세포 계대(B,D) 또는 모기 세포 계대(C,E)에서 확인된 각 DVG 후보를 293T 세포(B,C) 또는 U4.4 세포(D,E)에 1:1 또는 10:1 몰비로 CHIKV Carib-루시퍼라제와 공동 형질감염시켰다. 48시간 후, 루시퍼라제 활성을 측정하였다. (3개의 독립적인 실험 중 하나의 실험에 대한 대표적인 결과가 표시되어 있다. n=3, *p<0,05, **p<0,01, ***p<0,001, ****p<0,0001, ns는 일원 분산 분석 테스트에서 Dunnett 다중 비교 후 야생형과 비교하여 유의하지 않음을 나타냄.)
도 36: 결함이 있는 바이러스 게놈은 알파바이러스 과에서 광범위한 억제 활성을 나타낸다. 포유동물 세포 계대(A,C,E) 또는 모기 세포 계대(B,D,F)에서 확인된 DVG를 CHIKV IOL(A, B), 오니옹니옹 바이러스(ONNV)(C, D) 및 신드비스 바이러스(SINV)(E, F)의 감염에 대하여 테스트했다. DVG 후보는 293T 세포에 10:1 몰 비율로 CHIKV IOL(A,B), ONNV(C,D) 및 SINV(E,F)와 공동 형질감염시켰다. 48시간 후, 바이러스 역가를 측정하였다. (3개의 독립적인 실험 중 하나의 실험을 대표하는 결과, n=3, *p<0,05, **p<0,01, ***p<0,001, ****p<0,0001, ns는 일원 분산 분석 테스트에 대한 Dunnett 다중 비교 후 야생형과 비교하여 유의하지 않음을 나타냄.)
도 37: 결함이 있는 바이러스 게놈은 이집트숲모기에서 치쿤구니야 바이러스의 바이러스 전파를 예방한다. (A) 150 ng의 DVG 후보 RNA(IH1, CV4 또는 CM1), 대조군 RNA 또는 PBS를 106 PFU/ml를 함유하는 감염된 혈분을 공급하기 2일 전에 이집트숲모기에 주입했다. 5일 후, 모기를 희생시키고, 사체에서 중장을 분리하였다. (B) 각 모기의 중장 또는 사체의 루시페라제 활성을 측정하였다. (C) 바이러스 적정 후, 양성 중장 또는 사체의 비율(예: PFU≥100 PFU/ml)을 측정하였다. (2개의 독립적인 실험 중 하나의 실험의 대표적인 결과가 표시됨, n=24, *p<0,05, **p<0,01, ***p<0,001, ns는 다중 비교를 이용한 일원 ANOVA(B) 또는 Holm 보정을 사용한 카이 제곱 검정, 다중 비교(C)후 PBS에 비해 유의하지 않음을 나타냄).
도 38: 치쿤구니야 바이러스 DVG는 자가 복제되지 않는다. 세포를 DVG 또는 CHIKV Carib 시험관내 전사된 RNA로 형질감염시키고 형질감염 후 8, 20, 28 및 44시간에 수확하였다. 세포 RNA를 추출하여 Taqman 프로브로 RT-qPCR을 수행하는데 사용했다.
도 39: 바이러스 적정에 의한 시험관내 DVG 활성의 측정. 각 DVG 후보(모기 세포에서 유래)의 시험관내 전사된 RNA를 U4.4 세포에 1:1 또는 10:1 몰비로 CHIKV Carib-luciferase RNA와 공동 형질감염시켰다. 48시간 후, 샘플을 적정하고 루시퍼라제 활성을 측정했다(도 34E). (n=3, **p<0,01, ****p<0,0001, ns는 일원 ANOVA 테스트에서 Dunnett 다중 비교 후 야생형과 비교하여 유의하지 않음을 나타냄).
도 41은 연구된 CHIKV DVG의 특성을 나열한다. DVG, 결함이 있는 바이러스 게놈; CHIKV, 치쿤구니야 바이러스; 결실 위치, 외피 단백질(E), 비구조 단백질(NSP) 또는 3' 비번역 영역(3'UTR)을 포함할 수 있는 결실에 의해 영향을 받는 게놈 영역.
고찰
거의 모든 RNA 바이러스 과에서 기술되어 설명되어 있으며 6,21 종종 바이러스 복제의 폐기물로 간주되는 결함이 있는 간섭 입자, 보다 광범위하게 말하면 DVG는 최근 항바이러스 도구서로의 그의 사용 가능성 때문에 주목을 받았습니다15,6,22-26. 실제로, 자연적인 인간 감염에서 DVG의 존재는 호흡기 세포융합 바이러스 및 인플루엔자 바이러스에 대한 임상 연구에서 더 가벼운 질병과 상관관계가 있고10,13; 인플루엔자 결함이 있는 간섭 입자는 치명적인 감염공격으로부터 마우스를 보호한다22,23,27. 본 연구에서, 본 발명자들은 포유동물 및 모기 환경에서 시험관내 및 모기 숙주에서 생체내에서 치쿤구니야 바이러스 감염 동안 발생하는 결실을 갖는 DVG를 가능한 한 광범위하게 특성 규명하는 것을 목표로 했다. 본 발명자들은 치쿤구니야 DVG가 시험관내 및 생체내 환경 모두에서 발생하지만 그의 유형과 풍부도는 숙주와 세포 유형, 바이러스 균주에 따라 달라지며, 이는 세포 환경 및 바이러스 게놈이 DVG 생성의 결정 요인(determinant)을 지니고 있음을 강조한다. 예를 들어, 클러스터 D는 Aedes 종 모기 세포 모두에서 강력하게 나타나며, 그 결실이 정확히 같은 위치에서 발생하지는 않지만 포유동물 세포에서는 매우 드물다.
항바이러스제로 유용할 수 있는 DVG를 찾기 위해, 본 발명자들은 여러 조건에서 발생하고 계대를 통해 전파된 가장 중복된 DVG를 선택했고, 본 발명자들은 이 DVG는 더 높은 적합성과 야생형 바이러스에 의해 패키징될 수 있는 능력을 나타내는 것으로 가정했다. 야생형 바이러스에 비해 더 많은 양을 사용할 때, 대부분의 후보는 유망한 억제 능력을 보여주었다. 참고로, 더 작은 게놈은 더 빨리 복제되므로7,8, 기존의 도그마(dogma)는 가장 작은 DVG가 모체 바이러스 복제 기계를 가장 효율적으로 가로채고 야생형 바이러스를 압도할 것이라고 제안하고 있다. 그러나, 본 발명자들의 연구에서, 식별된 가장 작은 DVG(클러스터 B 유래의 DVG 2개)에는 간섭 활성이 없거나 거의 없었다. 이 관찰 결과는 복제효소 및 복제 속도에 대한 엄격한 경쟁이 DVG가 모체 바이러스를 방해하는 유일한 메커니즘이 아니며 이전에 설명한 면역 자극 활성-7,9-11,28-33 또는 구조적 단백질 자원에 대한 경쟁34이 또한 중요한 역할을 할 수 있음을 의미한다. 중요한 것은 DVG를 식별하기 위해 작은 리드만을 생성하는 Illumina 딥 시퀀싱 기술을 사용하면 다양한 결실 및/또는 주요 재배열을 갖는 DVG를 식별하는 것이 거의 불가능하다는 것이다. 미래에, 이러한 접근 방식을 나노포어(nanopore)와 같은 긴-리드 시퀀싱 기술과 통합하면, 치쿤구니야 바이러스 집단에서 생성된 DVG의 특성에 대한 훨씬 더 완전한 그림을 생성하고 이들의 작용 방식을 알 수 있다.
이집트숲모기 생체내에서 생성된 DVG 중, CM1은 생체내에서 병목 현상을 일으킬 수 있기 때문에 본 발명자들의 관심을 끌었다. 자연 바이러스 감염 동안, 감염성 혈분 공급 후, 중장은 바이러스가 혈구에 도달하여 다른 모든 기관으로 전파되기 전에 감염되는 첫 번째 장기이다35. 모기에 대한 여러 연구에 따르면, 중장의 바이러스 출구가 모기 감염 시 주요 집단 병목으로 작용하여 집단 크기를 급격히 감소시킨 다음, 침샘에서 빠져나와 바이러스가 감염된 타액을 통해 포유동물 숙주로 전파되는 필수 단계인 것으로 확인되었다35-39. CM1은 두 개의 독립적인 모기의 중장에서 새로 생성되었으며 이들 동일한 모기의 체벽, 머리 및 다리/날개에 전파되는 것으로 확인되었다. CM1이 다른 장기에서 새로 생성되었을 가능성은 거의 없는데 이는 DVG가 중장에서 생성되지 않은 다른 모기의 어떤 기관에도 나타나지 않았기 때문이다. CM1이 중장 병목을 넘을 수 있는 방법 또는 이유는 명확하지 않다. 한 가지 가능성은 이는 다배체 비리온, 비리온 응집체 또는 비리온 함유 지질 소포와 같은, 다수의 바이러스 게놈을 동시에 포함하고 이를 단일 세포에 수송하는 구조인 집단 감염성 바이러스 단위(collective infectious viral unit)에 속한다는 것이다40,41. DVG를 포함하는 집단 감염성 단위의 가능성은 이미 제안되었다. 실제로, Leeks 등은. 바이러스 집단에 많은 DVG가 포함되어 있으면 집단 감염성 단위가 매우 커질 수 있다고 모델링했다. 그럼에도 불구하고, 간섭 DVG의 존재는 자유 비리온에 비해 집단 감염성 단위 내에서 전염을 선호하지 않을 것이다42. CM1은 부모 바이러스에 비해 높은 몰비에서 억제 활성을 가졌으나, 모기 샘플에서의 그의 빈도는 매우 낮았다(백만 당 4 내지 176 리드).
이러한 간섭 DVG 중 몇몇의 가치 있는 특성은 다른 치쿤구니야 바이러스 균주뿐만 아니라 다른 알파바이러스도 억제하는 광범위한 활성이다. 이러한 교차 반응성은 인플루엔자 및 센다이 바이러스의 경우에 이미 보고된 바 있는데, 그 이유는 이들의 DVG가 이들이 유래된 바이러스뿐만 아니라 관련 없는 바이러스에 대해서도 포유동물 모델에서 효율적인 백신 또는 백신 보조제인 것으로 확인되었기 때문이다15,22-26. 치료적 관점에서 이는 특히 중요하며, 그 이유는 관절형성 알파바이러스의 전세계적인 전파의 위험이 잘 받아들여지고 있고3,43-47, 특히 이러한 바이러스에 대한 항바이러스제나 백신이 현재 허가되지 않았기 때문이다. 이러한 맥락에서, 바이러스 속 또는 과에 걸쳐 작용할 수 있는 임의의 치료법(항바이러스 또는 백신)은 다가올 발병에 대처하는데 도움이 될 것이다.
치쿤구니야 DVG가 포유류 생체내 모델에서도 항바이러스제로 기능할 수 있는지 테스트하는 것은 미래에 중요할 것이다. 그러나, 적절한 전달 시스템은 여전히 개발될 필요가 있다. 인플루엔자 A 및 센다이 DVG에 대한 이전 연구에서, 저자는 수크로스 구배에서 야생형 바이러스와 DVG의 혼합물을 초 원심분리하여 DVG를 분리했다15,22-26. 그러나, 본 발명자들은 이러한 방법을 사용하여 야생형 바이러스로부터 치쿤구니야 DVG를 성공적으로 분리할 수 없었다. RNA 또는 DNA를 나노입자 또는 나노구조 지질로 전달하거나48,49, DVG를 바이러스 유사 입자(VLP)에 패키징하는 것과 같은 새로운 접근 방식을 탐색할 수 있다. 극복해야 할 또 다른 주요 장애물은 생체내 모델의 선택이다. 야생형 C57BL/6을 사용할 수 있지만, 마우스는 일시적이고 가벼운 감염만을 발생하기 때문에 최상의 DVG 후보의 경우에도 억제 효과를 입증하기가 어려울 것이다. 가장 일반적으로 사용되는 마우스 모델은 인터페론 α/β 녹아웃에 의존하지만50,51, 치쿤구니야 DVG에서 중요한 작용 기전일 수 있는 선천 면역의 유도는 제외되어 있다10,28-31,33.
마지막으로, 전염성 혈분 공급 2일 전에 이집트숲모기에 주입했을 때, 3개의 DVG가 모기 중장에서 바이러스 전파를 유의하게 감소시킴으로써, 모기의 상태를 치쿤구니야 바이러스 전파에 대한 유능한 벡터(vector)로부터 무능한 벡터로 전환했다. 이러한 결과는 DVG가 벡터 집단에서 치쿤구니야 바이러스 감염을 통제하는데 유용한 도구가 될 수 있다는 원리의 증거이다. 아르보바이러스가 발생하는 동안 무능한 모기를 야생에 방출하는 것이 효과적인 전염병 통제 전략으로 이미 입증되었고52,53, 더 간단한 전달 시스템이 필요함에도 불구하고, 간섭 DVG를 치쿤구니야 바이러스뿐만 아니라 임의의 아르보바이러스에 대한 방제 전략으로 사용할 수 있다는 제안은 유혹적이다. 또한, 간섭 DVG는 자가 복제할 수 없는 비활성 분자이고 야생형 바이러스가 존재할 때만 활성이기 때문에 아마도 안전한 항바이러스 도구일 것이다.
결론적으로, 본 연구는 모기 벡터에서 생체내 및 시험관내 척추동물 및 무척추동물 환경 모두에서 치쿤구니야 바이러스 감염 동안 생성된 다양한 유형의 결실된 DVG를 설명한다. 더욱이, 본 발명자들은 척추동물 및 무척추동물 숙주 모두에서 시험관내에서 야생형 치쿤구니야 바이러스를 억제할 수 있는 최상의 결함이 있는 간섭 입자 후보를 하향 선택하는 기준을 확인했다. 흥미로운 관찰 결과는 관련 알파바이러스와 상호작용할 수 있는 몇몇의 간섭 DVG의 광범위한 활성이다. 마지막으로, 본 발명자들은 DVG에의 사전 노출이 생체내에서 모기 내의 바이러스 전파를 조절할 수 있음을 보여준다. 이러한 결과는 결함이 있는 간섭 입자가 효과적인 벡터 제어 전략일 뿐만 아니라 치쿤구니야 바이러스 감염에 대한 유용한 치료 도구가 될 수 있다는 아이디어를 강화한다.
CHIKV DVG 서열은: 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3) 및 서열 번호: 53 (CHIKV DVG-CA4)로 이루어지는 군으로부터 선택된다.
바람직한 CHIKV DVG 서열은: 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3) 및 서열 번호: 53 (CHIKV DVG-CA4)로 이루어지는 군으로부터 선택된다.
가장 바람직한 CHIKV DVG 서열은: 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 38 (CHIKV DVG-IH1) 및 서열 번호: 43 (CHIKV DVG-CV4)로 이루어지는 군으로부터 선택된다.
실시예 5: 리노바이러스(RV)
리노바이러스 내에서 발생하는 DVG의 생성 및 특성규명
방법: 결함 있는 바이러스 게놈(DVG)의 식별에 사용되는 리노바이러스(RV) 유형에는 RV-A01a(NC_038311.1), RV-A16(L24917.1), RV-B14(L05355.1) 및 RV-C15(GU219984.1)가 포함된다. 간단히 말해서, 12웰 플레이트에 완전 배지(DMEM, 10% FBS, 1% 페니실린/스트렙토마이신)에 있는 3.5 x 105(350,000) H1-HeLa 세포를 접종하고 약 90% 컨플루언시에 도달하도록 37℃/5%O2에서 밤새 인큐베이션했다. RV-C15 바이러스의 경우, HeLa-E8 세포주를 사용하였다. 다음날, 세포를 높은(20) 및 낮은(0.1) 감염 다중도(MOI)로 야생형 RV-A01a, RV-A16, RV-B14 및 RV-C15 바이러스에 감염시켰다. 37℃/5%O2에서 1시간 동안 인큐베이션한 후, 바이러스를 제거하고 세포를 인산완충식염수(PBS) 용액으로 세척하였다. 그 다음, PBS를 흡인하고 1 mL의 감염 배지(DMEM, 2% FBS, 1% 페니실린/스트렙토마이신)를 첨가하였다. 세포를 완전한 세포변성 효과(CPE)가 관찰될 때까지 37℃/5%O2에서 인큐베이션하였다. CPE 시, 바이러스는 3회 반복된 동결-해동 사이클에 의해 수확하였고, 세포 파편은 원심분리(4℃에서 10분 동안 17,000 x g)에 의해 제거하였다. 바이러스 상층액을 분취하고 사용시까지 -80℃에서 보관하였다. 상층액을 사용하여 바이러스를 신선한 세포에 계대시켰다. 이 과정은 계대 10까지 반복하였다(도 42). 바이러스 RNA 분리 전, 100 ㎕의 바이러스 상층액을 5 ㎕의 RNase A/T1(Thermo Scientific사)로 처리하고 그 혼합물을 37℃에서 1시간 동안 인큐베이션하였다. RNase 처리 후 바이러스 상층액 100 ㎕당 TRI 시약(Sigma사) 300 ㎕를 첨가하여 균일하게 혼합하였다. 이후, Direct-zol-96 RNA 키트(Zymo Research사)를 이용하여 RNA를 분리하였다. 컬럼 내 DNase 처리는 제조사의 프로토콜에 따라 수행하였다. 5 마이크로리터의 분리된 RNA(일반적으로 ≤1 ng/㎕)를 라이브러리 제조에 사용했다. Illumina용 NEBNext Ultra II RNA Library Prep 키트(New England Biolabs사)를 사용하여 라이브러리를 제조했다. 라이브러리 과정 동안 멀티플렉스 올리고(Illumina사)를 사용했다. 라이브러리 제조 품질은 고감도 DNA 칩을 사용하여 Bioanalyser 2100(Agilent사)에서 확인했다. 1 nM로 희석된 라이브러리의 시퀀싱은 NextSeq 500 Mid Output 키트 v2.5(Illumina사)를 이용하여 NextSeq 500 시퀀서(Illumina)에서 수행하였다(151 사이클). 획득한 시퀀스를 사내(in-house) 파이프라인을 통해 분석하여 DVG를 식별했다.
수많은 RV 유형의 존재를 고려하여, 본 발명자들은 RV-A01a, -A16, -B14 및 -C15로 실험을 수행하여 모든 RV 종이 데이터 세트 내에 표시되도록 하였다. 이들 바이러스는 위에서 설명한 대로 H1-HeLa 세포주에서 낮은 MOI 및 높은 MOI에서 최대 10회 계대하였다(도 42). 샘플의 심층 시퀀싱 및 생물정보학 분석을 통해 집단 내의 RV 게놈 전반에 걸쳐 모든 결실 핫스팟을 식별했다. 테스트된 모든 RV 유형의 경우, 주요 결실 핫스팟은 게놈의 P1 영역(구조 단백질) 내에 포함되며 모두 프레임 내에 있다(도 43 내지 도 46). 또한, 모든 샘플은 RNA 분리 및 심층 시퀀싱 전에 RNase로 처리하었으며, 이는 식별된 DVG가 바이러스 캡시드에 패키징될 수 있음을 시사한다. 주요 핫스팟 내의 DVG와 관련하여, 모든 경우에 cis-작용 복제 요소(cre)가 보존되었으므로, 이들은 다른 DVG에 비해 복제 이점이 있다.
TIP 후보의 선택은 핫스팟의 존재, 게놈을 따른 위치, 결실의 크기 및 계대 내에/계대에 걸친 각 결실의 출현 빈도를 기반으로 수행하였다. TIP 후보의 명칭에는 RV 유형과 TIP 번호(예: B14-TIP-01)가 포함된다(도 47 및 도 48).
도 42. 리노바이러스 결함이 있는 바이러스 게놈을 생성하는데 사용되는 방법. 전체 과정은 낮은/높은 MOI에서 블라인드 계대배양 이후, 바이러스 RNA 정제, 심층 시퀀싱 및 결함이 있는 바이러스 게놈(DVG)을 식별하기 위한 데이터 분석을 포함했다. 계대하기 전에, 12웰 플레이트에 완전 배지(DMEM, 10% FBS, 1% 페니실린/스트렙토마이신)에서 3.5 x 105 H1-HeLa 세포/웰을 접종한 다음 37℃/5% CO2에서 24시간 동안 인큐베이션했다. RV-A01a, RV-A16 및 RV-B14의 경우, H1-HeLa 세포를 사용했다. RV-C15의 경우, HeLa-E8 세포를 사용했다. 실험 당일, 세포(약 90% 컨플루언시)는 MOI 0.1(낮은 MOI) 및 MOI 20(높은 MOI)로 감염시켰다. 감염된 세포를 34℃/5% CO2에서 1시간 동안 인큐베이션하였다. 인큐베이션 후, 바이러스를 제거하고, 세포를 1x PBS로 세척한 다음, 새로운 감염 배지(DMEM, 2% FBS, 1% 페니실린/스트렙토마이신)를 첨가하였다. 세포를 완전한 세포변성 효과(CPE)가 관찰될 때까지 34℃/5% CO2에서 인큐베이션하였다. CPE 시, 바이러스를 3회 반복된 동결-해동 사이클에 의해 수확하였고, 세포 파편은 원심분리(4℃에서 10분 동안 17,000 x g)에 의해 제거하였다. 이 과정을 계대 10까지 반복했다.
도 43. 높은 역가에서 H1-HeLa 세포에서 RV-A01a의 계대. (A) P1(구조적) 암호화 영역 내의 주요 결실 클러스터 형태 및 이 클러스터 내의 결함 바이러스 게놈(DVG)은 모두 프레임 내에 있다. 그래프는 식별된 결실의 시작 대(vs.) 중지 위치를 나타낸다. 결실의 크기에 따라, 데이터를 프레임 내(왼쪽, 빨간색 원) 결실 및 프레임 외(오른쪽, 청록색 원) 결실로 분할했다. 모든 계대(P01-P10) 및 모든 복제(n = 5) 유래의 데이터를 풀링했다. (B) 계대 수(P01-P10)에 따른 결실의 모양. 각 패널은 모든 복제(n = 5) 유래의 풀링된 데이터를 나타낸다. 맨 위 행의 패널은 프레임 내 결실을 나타내는 반면, 맨 아래 행의 패널은 게놈 전체에서 프레임 외 결실을 나타낸다.
도 44. 높은 역가에서 H1-HeLa 세포에서 RV-A16의 계대. (A) P1(구조적) 암호화 영역 내의 주요 결실 클러스터 형태 및 이 클러스터 내의 결함 바이러스 게놈(DVG)은 모두 프레임 내에 있다. 그래프는 식별된 결실의 시작 대(vs.) 중지 위치를 나타낸다. 결실의 크기에 따라, 데이터를 프레임 내(왼쪽, 빨간색 원) 결실 및 프레임 외(오른쪽, 청록색 원) 결실로 분할했다. 모든 계대(P01-P09) 및 모든 복제(n = 5) 유래의 데이터를 풀링했다. (B) 계대 수(P01-P09)에 따른 결실의 모양. 각 패널은 모든 복제(n = 5) 유래의 풀링된 데이터를 나타낸다. 맨 위 행의 패널은 프레임 내 결실을 나타내는 반면, 맨 아래 행의 패널은 게놈 전체에서 프레임 외 결실을 나타낸다.
도 45. 높은 역가에서 H1-HeLa 세포에서 RV-B14의 계대. (A) P1(구조적) 암호화 영역 내의 주요 결실 클러스터 형태 및 이 클러스터 내의 결함 바이러스 게놈(DVG)은 모두 프레임 내에 있다. 그래프는 식별된 결실의 시작 대(vs.) 중지 위치를 나타낸다. 결실의 크기에 따라, 데이터를 프레임 내(왼쪽, 빨간색 원) 결실 및 프레임 외(오른쪽, 청록색 원) 결실로 분할했다. 모든 계대(P01-P10) 및 모든 복제(n = 6) 유래의 데이터를 풀링했다. (B) 계대 수(P01-P10)에 따른 결실의 모양. 각 패널은 모든 복제(n = 6) 유래의 풀링된 데이터를 나타낸다. 맨 위 행의 패널은 프레임 내 결실을 나타내는 반면, 맨 아래 행의 패널은 게놈 전체에서 프레임 외 결실을 나타낸다.
도 46. 높은 역가에서 HeLa-E8 세포에서 RV-C15의 계대. (A) P1(구조적) 암호화 영역 내의 주요 결실 클러스터 형태 및 이 클러스터 내의 결함 바이러스 게놈(DVG)은 모두 프레임 내에 있다. 그래프는 식별된 결실의 시작 대(vs.) 중지 위치를 나타낸다. 결실의 크기에 따라, 데이터를 프레임 내(왼쪽, 빨간색 원) 결실 및 프레임 외(오른쪽, 청록색 원) 결실로 분할했다. 모든 계대(P01-P10) 및 모든 복제(n = 5) 유래의 데이터를 풀링했다. (B) 계대 수(P01-P10)에 따른 결실의 모양. 각 패널은 모든 복제(n = 5) 유래의 풀링된 데이터를 나타낸다. 맨 위 행의 패널은 프레임 내 결실을 나타내는 반면, 맨 아래 행의 패널은 게놈 전체에서 프레임 외 결실을 나타낸다.
도 47. 리노바이러스 TIP 후보. (A) 리노바이러스(RV)-B14, (B) RV-A01a, (C) RV-A16 및 (D) RV-C15 TIP 후보. TIP 후보의 명칭에는 RV 유형 및 TIP 번호가 포함된다(예: B14-TIP-01). 결실은 수평 빨간색 선으로 표시되는 반면, 돌연변이는 수직 빨간색 선으로 표시되어 있다. 각 도면 패널의 상단에는 표시된 바이러스 단백질의 위치와 함께 각 바이러스 유형에 대한 야생형 게놈이 표시되어 있다(진한 회색). VP4, VP2, VP3 및 VP1의 순서로 구조 단백질이 나타난다. 비구조 단백질은 2A, 2B, 2C, 3A, 3B, 3C, 3D의 순서로 나타난다. x축은 바이러스 게놈 길이(뉴클레오티드(nts))를 나타낸다.
도 48: 리노바이러스 TIP 후보의 세부사항. 각 TIP 후보의 보고된 특성에는 ID, 결실 시작 및 중지 위치, 결실 길이(DEL LENGTH = STOP - START), 돌연변이(있는 경우), 및 결실이 프레임 내 또는 프레임 외에서 오픈 리딩 프레임(ORF)을 유지하는지 여부가 포함된다. 결실이 3으로 나누어 질 수 있으면(나머지 = 0), 이는 프레임 내에 있고 그렇지 않으면 프레임 외에 있다. 시작 및 중지 위치는 각각 마지막으로 남은 것과 마지막으로 결실된 것을 나타낸다.
리노바이러스 TIP 후보는 시험관내에서 야생형 바이러스를 억제한다
방법: 형질감염 전에, 96웰 플레이트에 완전 배지(DMEM, 10% FBS, 1% 페니실린/스트렙토마이신)에 있는 2.0 x 104 H1-HeLa 세포를 접종한 다음 37℃/5% CO2에서 24시간 동안 인큐베이션하여 약 90% 컨플루언시에 도달하도록 하였다. 완전한 배지를 감염 배지(DMEM, 2% FBS, 1% 페니실린/스트렙토마이신)로 교체하고 세포를 TransIT-mRNA 형질감염 시약을 사용하여 표시된 몰비에서 야생형 및 선택된 TIP 후보로 공동 형질감염시켰다. 모든 공동 형질감염은 1:1, 1:5 및 1:10(WT:TIP) 몰비및 삼중(n = 3)으로 수행되었다. WT RNA 단독의 경우, "1"의 양은 25 ng의 RNA와 같다. 형질감염된 세포를 34℃/5% CO2에서 48시간 동안 인큐베이션하였다. 인큐베이션 후, 바이러스를 3회 반복된 동결-해동 사이클에 의해 수확하고, 세포 파편을 원심분리(4℃에서 10분 동안 17,000 x g)로 제거하였다. 감염성 바이러스의 역가는 플라크 분석에 의해 결정하였다. 대조군으로서, WT RNA를 대조군 RNA(pTRI-Xef: Xenopus elongation factor 1α)로 공동 형질감염시켰고, 이는 WT 단독과 유사한 역가를 초래하였다. 대조군 RNA 단독, TIP 후보 단독 및 모의 형질감염을 포함한 추가 대조군도 테스트하였으며, 이는 예상대로 감염성 바이러스를 생성하지 않았다. 최고 성능의 TIP 후보의 판리노바이러스 활성은 RV-A01a 및 RV-A16의 WT RNA를 사용하여 동일한 방식으로 테스트하였다.
결과는 TIP 후보의 이러한 선택 세트로부터, B14-TIP-03 후보가 WT 역가를 거의 100배 낮춤으로써 최상의 성능이 있음을 나타낸다(도 49A). 안전 특징(safety feature)으로서, 본 발명자들은 B14-TIP-03의 비복제 변형(K13L)을 생성하고 이를 "B14-TIP-06"으로 재명명했다. B14-TIP-06은 B14-TIP-03과 유사한 항바이러스 활성을 가지고 있다(도 49B). WT RNA의 맥락에서 동일한 돌연변이를 통합해도 예상대로 생존가능한 바이러스가 생성되지 않았다(도 49B). 이러한 결과는 DVG를 잠재적 TIP로 사용하는 안전성의 측면에서 중요한 의미를 갖는다.
본 발명자들의 시험관내 결과는 B14-TIP-03의 항바이러스 기능이 판리노바이러스성(panrhinoviral)임을 나타낸다. B14-TIP-03을 RV-A01a 및 RV-A16과 동시 형질감염시키면 감염성 바이러스 역가가 크게 감소한다. B14-TIP-03이 다수의 RV 유형에 대한 광범위한 항바이러스제로 사용될 가능성을 더욱 강화한다.
도 49. 판리노바이러스 TIP 후보는 시험관내에서 야생형 역가를 감소시킨다. (A) TIP 후보(B14-TIP-01, B14-TIP-03 및 B14-TIP-10)의 효능을 평가하기 위해 RV-B14-WT 및 TIP-후보 RNA를 H1-HeLa 세포에 공동 형질감염시켰다. 모든 공동 형질감염은 1:1, 1:5 및 1:10(WT:TIP) 몰비로 수행되었다. B14-WT 단독의 경우, "1"의 양은 25 ng의 RNA와 같다. 대조군으로서, RV-B14-WT RNA를 단독으로 또는 대조군 RNA(pTRI-Xef: Xenopus elongation factor 1α)와 함께 형질감염시켰다. 대조군 RNA 단독, TIP 후보 단독 및 모의 형질감염을 포함한 추가 대조군도 테스트하였으며, 이는 예상대로 감염성 바이러스를 생성하지 않았다. (B) B14-TIP-03의 비복제성 변이체(K13L 변이체 - 3C 단백질 내) TIP를 제작하고 이를 "B14-TIP-06"으로 재명명하였다. B14-TIP-06 TIP 후보는 B14-TIP-03 TIP 후보와 유사한 항바이러스 활성을 갖는다. WT 게놈의 맥락에서 동일한 돌연변이를 도입하는 것은 예상대로 실행 가능하지 않았다. (C) B14-TIP-03의 판리노바이러스 활성은 TIP 후보를 RV-B14, RV-A01a 및 RV-A16 야생형 게놈과 공동 형질감염시킴으로써 테스트하였다. x축은 테스트한 WT:TIP 샘플과 그의 몰비(괄호 안)를 나타내고, y축은 Log10(PFU/mL)을 나타낸다. 각 조건은 적어도 세 번 테스트되었다(n ≥ 3).
리노바이러스 TIP 후보는 시험관내에서 항바이러스성 선천 면역의 강력한 자극제이다
방법: 형질감염 전에, 96웰 플레이트에 완전 배지(DMEM, 10% FBS, 1% 페니실린/스트렙토마이신)에 있는 2.0 x 104 H1-HeLa 세포를 접종한 다음 37℃/5% CO2에서 24시간 동안 인큐베이션하여 약 90% 컨플루언시에 도달하도록 하였다. 완전한 배지를 감염 배지(DMEM, 2% FBS, 1% 페니실린/스트렙토마이신)로 교체하고 세포를 TransIT-mRNA 형질감염 시약을 이용하여 1:10(WT:TIP) 몰비의 WT 및 B14-TIP-03으로 공동 형질감염시켰다. "1"의 양은 25 ng의 WT RNA와 같다. 모든 공동-형질감염은 삼중으로(n = 3) 수행되었다. 형질감염된 세포를 34℃/5% CO2에서 3시간 동안 인큐베이션한 후, 입력 RNA를 제거하고 이 RNA가 RT-qPCR 실험을 방해하는 것을 방지하기 위해 인산염 완충 식염수로 여러 번 세척하였다. 그 다음, 형질감염된 세포를 34℃/5% CO2에서 48시간 동안 인큐베이션하였다. 인큐베이션 후, 바이러스를 3회 반복된 동결-해동 사이클로 수확하고, 세포 파편을 원심분리(4℃에서 10분 동안 17,000 x g)로 제거하였다. 바이러스 RNA를 분리하기 위해, Direct-zol RNA Miniprep 키트(Zymo Research사)를 제조사의 권장 프로토콜에 따라 사용했다. 그런 다음, 제조사의 권장 프로토콜에 따라 SuperScript IV(ThermoFisher) 역전사 효소 및 무작위 헥사머 프라이머를 사용하여 총 RNA를 역전사했다. 그런 다음, 2 ㎕의 10배 희석된 cDNA를 레티노산 유도성 유전자 I(RIG-I), 흑색종 분화 관련 유전자 5(MDA5), 인터페론(IFN)-α1, IFN-β1 및 IFN-λ1 유전자에 대한 유전자-특이적 프라이머를 사용하여 Power SYBR® Green PCR Master Mix를 사용하여 증폭했다. 상대적 배수 변화(fold-change) 계산은 대조군으로 GAPDH(glyceraldehyde 3-phosphate dehydrogenase) 하우스키핑 유전자를 사용하여 모의 형질감염된 세포에 대한 △△Ct 분석을 사용하여 수행하였다.
결과: qPCR 결과에 따르면, B14-TIP-03은 항바이러스성 선천 면역의 강력한 자극제이다. RV-B14-WT와 대조군 RNA(pTRI-Xef: Xenopus elongation factor 1α)의 공동 형질감염은 테스트된 모든 유전자의 약한 유도를 초래했다. 한편, RV-B14-WT과 B14-TIP-03 RNA의 공동 형질감염은 RIG-I 및 MDA5와 같은 패턴 인식 수용체(PRR)의 유전자 발현을 유의하게 증가시켰다. 또한, B14-TIP-03은 IFN-β1 및 IFN-λ1의 유전자 발현을 유도했지만, IFN-α1의 유전자 발현은 유도하지 않았다. 이러한 결과는 B14-TIP-03의 주요 작용 메커니즘을 나타낸다.
도 50. TIP 후보 B14-TIP-03은 항바이러스성 선천 면역의 강력한 자극제이다. 배수 변화 값은 각 막대 위에 표시되어 있다. 모든 공동 형질감염은 1:10(WT:TIP) 몰비로 수행되었다. B14-WT 단독의 경우, "1"의 양은 25 ng의 RNA와 같다. 대조군으로서, RV-B14-WT RNA를 대조군 RNA(pTRI-Xef: Xenopus elongation factor 1α)와 함께 형질감염시켰다. x축은 테스트한 WT:TIP 샘플을 나타내고, y축은 Log10(PFU/mL)을 나타낸다. 각 조건은 이중으로 테스트되었다.
식별된 DVG가 도 51 및 52에 나타나 있다.
RV DVG 서열은: 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19) 및 서열 번호: 87 (RV DVG B14-TIP-20)로 이루어지는 군으로부터 선택된다.
바람직한 RV DVG 서열은: 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 73 (RV DVG B14-TIP-06) 및 서열 번호: 77 (RV DVG B14-TIP-10)로 이루어지는 군으로부터 선택된다.
가장 바람직한 RV DVG 서열은: 서열 번호: 70 (RV DVG B14-TIP-03) 및 서열 번호: 73 (RV DVG B14-TIP-06)로 이루어지는 군으로부터 선택된다.
실시예 6: 황열병 바이러스(YFV)
황열병 바이러스 계대 내에서 발생하는 DVG의 생성 및 특성규명
황열병 바이러스 아시비(YF-Asibi) 균주 및 백신(YF-17D) 균주를 포유동물(SW13, Vero) 및 모기(C6/36) 세포주에서 높고 낮은 MOI로 12개의 생물학적 복제물에서 10 내지 20회 블라인드 계대하였다. 도 53은 수행된 모든 계대 유래 샘플의 초점 형성 분석법에 의한 적정을 나타낸다. 그래프는 로그 눈금(logarithmic scale)의 바이러스 역가(ffu/ml로 표시됨) 및 각 계대에 대한 MOI 값을 모두 보여준다. 각 실험에서, 4회의 계대가 시퀀싱을 위해 선택되었으며, 바이러스 역가가 떨어지기 전의 계대로서 선택되었다. 현재, SW13에서 YF-Asibi 및 YF-17D의 높은 MOI 감염 및 낮은 MOI 감염 유래의 샘플은 이미 심층 시퀀싱이 완료되었으며 다른 샘플은 라이브러리 제조를 위해 준비되어 있다.
시퀀싱된 계대에 대한 컴퓨터 분석은 게놈 전반에 걸친 모든 결실 핫스팟 및 집단 내에서 발생하는 전체 DVG를 식별했다. 도 54는 SW13 세포에서 높은 MOI 및 낮은 MOI에서 YF-17D 및 YF-Asibi 계대의 시퀀싱으로부터 얻어지는 히트맵이다. 각 패널은 다른 MOI를 나타내며 각 행은 다른 계대를 나타낸다. 여기에 도시된 데이터는 모든 생물학적 복제물을 함께 통합한 것이다. 뉴클레오티드 위치는 x에 표시되며 전체 게놈에 걸쳐 있다. 분석에 따르면, 결실 핫스팟은 계대에 공통적이고 계대 동안 보존되며, 이는 이러한 DVG가 더 적합하고 새로운 세포를 감염시키기 위해 패키징될 수 있음을 시사한다. 이러한 데이터의 분석 결과는 높은 MOI와 낮은 MOI 모두에 공통적인 결실 핫스팟을 보여준다. 더욱이, 몇몇 결실 핫스팟은 두 바이러스 균주 모두에 공통적이다. 도 55에는 두 개의 YF 균주에서 발견된 DVG의 추가 비교가 도시되어 있다. 이 도면은 계대 시리즈가 진행됨에 따라 나타나고 보존되는 두 바이러스 균주 모두에서의 결실 클러스터를 강조하여 도시하고 있다(이러한 DVG의 높은 적합성을 암시함).
도 XX4에 개략적으로 도시된 가장 보존된 DVG가 TIP의 새로운 합성을 위해 선택되었다.
도 53: 블라인드 계대의 적정. 각 패널은 서로 다른 세포주에서 YF-17D 및 YF-Asibi의 연속적 블라인드 계대 동안 수집된 샘플을 보여준다. 샘플은 초점 형성 분석(FFA)을 사용하여 적정하였고 여기에서는 ml당 초점 형성 단위(ffu/ml)로 각 계대의 12회 반복의 평균으로 표시되어 있다. 각 계대의 계산된 감염에 대한 MOI는 12개의 복제(빨간색 막대)의 평균으로 표시되어 있다.
도 54: SW13 세포에서 DVG 식별. 선택된 계대 유래의 YF-Asibi 및 YF-17D 집단을 딥 시퀀싱(RNAseq)하였으며 YF 게놈 전체에 걸쳐 각각의 결실된 뉴클레오티드 위치(x축)의 정규화된 빈도가 히트 맵으로 도시되어 있다. 각 패널의 각 행은 다른 계대를 나타낸다. 각 패널은 사용된 2개의 YF 균주에 대한 높고 낮은 MOI 복제물에 대한 다른 계대 수를 나타낸다.
도 55: SW13 세포에서 YF DVG 핫스팟 식별. YF-17D(A) 및 YF-Asibi(B)를 사용하여 SW13 세포 계대에 대해 결실의 시작(x축) 및 중지(y축) 위치를 플로팅했다. 프레임 내(주황색) 및 프레임 외(청록색) 결실이 분석된 각 계대에 대해 도시되어 있다. 두 바이러스 균주에 대해 대략 500 내지 3000nt 시작-중지에서 시작 및 중지 위치가 있는 영역에서 명확한 핫스팟이 관찰되었다.
도 56: 후보 YF DVG의 개략도. YFV 후보 DVG는 계대 전반에 걸친 보존 및 빈도를 기반으로 선택되었다. 각 DVG의 기원은 왼쪽에 표시되어 있다. 왼쪽의 각 문자는 DVG의 임시 명칭을 나타낸다.
YFV DVG 서열은: 서열 번호:93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K) 및 서열 번호: 104 (YFV DVG-L)로 이루어지는 군으로부터 선택된다.
실시예 7: 웨스트 나일 바이러스(WNV)
웨스트 나일 바이러스 이스라엘 1998 균주(WNV)를 BHK 또는 C6/36 세포에서 높은 감염 다중도로 계대하였다. 간단히 말해서, 70 내지 80% 컨플루언시에 도달하도록 접종된 세포를 0.1 또는 10 PFU/세포의 초기 MOI로 감염시켰다. 감염 2일 후, 3 ㎕ 또는 300 ㎕의 감염된 세포 상층액(각각)을 후속 계대에서 감염에 사용하였다. 계대를 10회 반복하였다. 도 57은 BHK21 세포(도 57A 및 도 57B) 및 C6/36(도 57C 및 도 57D)에서 수행된 모든 계대 유래의 샘플의 적정(초점 형성 분석 방법에 의한) 및 RNA 정량(RT-QPCR에 의한)을 나타낸다. 샘플에서 추출한 RNA는 차세대 시퀀싱에도 사용하였다. RNA 라이브러리 제조 키트(Illumina사)를 사용하여 제조한 라이브러리를 150 사이클 단일-말단 리드를 사용하여 Illumina NextSeq500 시퀀서에 로드했다. 얻은 리드값은 위에서 설명한 컴퓨터 파이프라인을 사용하여 분석하였다. 시퀀싱된 계대에 대한 컴퓨터 분석은 게놈 전반에 걸친 모든 삭제 핫스팟과 집단 내에서 발생하는 전체 DVG를 식별했다. BHK21 또는 C6/36 세포에서 10회 계대한 후 최소 5개의 샘플에서 최소 10개의 nt가 결실된 적어도 2개의 리드에서 얻은 데이터를 분석한 결과 결실 핫스팟이 두 세포주에서 전체 게놈을 통해 흩어져 있지만 BHK21 세포에서 더 많다는 것이 확인되었다(도 58). 도 59는 BHK21(도 59A 및 도 59B) 및 C6/36(도 59C 및 도 59D)에서 낮은 MOI 및 높은 MOI에서 WNV 계대의 시퀀싱으로 얻어지는 결실 히트맵을 보여준다. 각 패널의 각 행은 다른 계대수를 나타낸다. 분석 결과는 결실 핫스팟은 모기 세포(C6/36)에서 계대하는 동안 공통적이고 보존된다는 것을 나타내며, 이는 이러한 DVG가 더 적합하고 새로운 세포를 감염시키기 위해 패키징될 수 있는 반면 결실 핫스팟은 포유동물 세포(BHK21)의 대하여는 훨씬 덜 명백하다는 것을 시사한다. 특정 결실 핫스팟은 C6/36 세포주에 고유하며 E 당단백질 내부 및 주변에 위치한 결실 핫스팟과 같이 빈도의 측면에서 다른 결실을 나타낸다(도 59C 및 D). 이러한 결실 클러스터는 높은 MOI(도 59D, 계대 5)보다는 낮은 MOI(도 59C, 계대 4)에서 더 일찍 나타나고 두 MOI의 경우 다음 계대에서 보존된다. 그러나, C6/36 세포에서 두 MOI에서 계대 5 이후 RNA의 감소로 인해(도 57D 참조) 계대 6 후에는 결실 히트맵이 생성될 수 없었다. C6/36 세포 계대 4, 5 및 6(높은 MOI) 및 3, 4 및 5(낮은 MOI)에 대한 핫스팟 결실은 결실의 시작 및 중지 위치를 플로팅함으로써 식별되었다(도 60). 히트맵에 의해 이미 예측된 바와 같이(도 59 참조), 두 MOI의 경우 계대 3에서, 높은 MOI의 경우 계대 4에서 약 500-3000nt 시작-중지에서 시작 및 중지 위치가 있는 영역에서 명확한 핫스팟이 관찰되었지만 모두 프레임 내에서만 있었다(도 60, 주황색 점과 파란색 점을 비교).
종합하면, 데이터는 다양한 조건에서 DVG의 전체 범위와 전반적인 적합성을 결정하기 위해 둘 이상의 세포주 또는 숙주를 사용하는 것의 중요성을 보여준다. 이들 데이터는 세포 유형 간에도 많은 차이가 있음을 강조할 뿐만 아니라 계대 시리즈가 진행됨에 따라 나타나는 결실 클러스터를 나타낸다(이들 DVG의 높은 적합성을 암시함).
이러한 분석 및 다른 분석로부터 본 발명자들은 DVG 후보 목록을 선택했다. 1에서 6까지 번호가 매겨진 후보는 도 61에 도시되어 있다. 후보는 다양한 크기에 걸쳐 있으며 결실은 프레임 내 및 프레임외에서 게놈의 서로 다른 위치에서 발생하여, 기존의 계대 및 분리를 사용하여 식별할 수 있는 것보다 더 광범위한 DVG 후보를 나타낸다.
도 57: 샘플 생성 - 연속 계대. 각 패널은 다양한 세포주에서 WNV의 연속 계대 동안 수집된 샘플을 보여준다. 샘플은 초점 형성 분석(FFA)을 사용하여 적정하였고 여기에서는 ml당 초점 형성 단위(ffu/ml, y축)로 각 계대(x축)에 대한 3개의 복제물의 평균(및 표준 편차)으로 표시되었다. BHK21(패널 A) 및 C6/36 세포(패널 C)에 대해 0.1(밝은 녹색) 또는 10(진한 녹색)의 감염 다중도(MOI)가 표시되어 있다. RNA 정량은 Total RNA isolation Nucleospin 키트를 사용하여, 클리어링된 상층액에서 RNA를 추출한 후 수행하였다. 이는 ml당 바이러스 RNA 카피 수(바이러스 RNA 카피/ml, y축)로 각 계대(x축)에 대한 3개의 복제물의 평균으로 표시되어 있고 0.1(밝은 녹색) 또는 10(진한 녹색)의 MOI의 경우 BHK21(패널 C) 및 C6/36 세포(패널 D)에 대해 표시되어 있다.
도 58: 10 계대 후 WNV 게놈에서의 결실. BHK21 또는 C6/36 세포에서 10회 계대 후 5개 이상의 샘플에서 10개 이상의 삭제된 뉴클레오티드가 있는 2개 이상의 리드 데이터의 분석. 결실 수 및 위치가 표시되어 있다.
도 59: BHK21 또는 C6/36 세포에서 계대된 WNV의 결실 히트맵. BHK21(패널 A 및 B) 또는 C6/36(패널 C 및 D) 세포에서의 10회 계대로부터의 WNV 집단을 심층 시퀀싱(RNAseq)하였고, 게놈 전체에 걸친 각각의 결실된 뉴클레오티드 위치(x축)의 정규화된 빈도(y축)가 히트맵으로 도시되어 있다. 각 패널의 각 행은 다른 게대를 나타낸다. 높은 MOI와 낮은 MOI에서의 계대가 각 세포 유형 마다 도시되어 있다.
도 60: C6/36 세포에서 핫스팟 결실의 식별. 결실의 시작(x축) 및 중지(y축) 위치를 WNV를 사용한 C6/36 세포 계대에 대해 플롯팅했다. 프레임 내(주황색) 및 프레임 외(청록색) 결실이 계대 4, 5 및 6(높은 MOI) 및 3, 4 및 5(낮은 MOI)에 대해 도시되어 있다. 두 MOI에 대해 대략 500 내지 3000 nt 시작-중지에서 시작 및 중지 위치가 있는 영역에서 명확한 핫스팟이 관찰된다.
도 61: 후보 WNV DVG의 개략도. WNV 후보 DVG는 C6/36 세포에서 계대하는 동안 보존 및 빈도에 따라 선택하였다. WT 게놈은 암호화된 단백질 C(보라색), prM(청색), E(청록색), NS1(진한 녹색), NS2A(연한 녹색), NS2B(노란색), NS3(주황색), NS4A(갈색), NS4B(분홍색) 및 NS5(빨간색)뿐만 아니라 5' 및 3' UTR(검은색 선)와 함께 상단에 도시되어 있으며, 뉴클레오티드 번호가 도시되어 있다. 후보 DVG는 1부터 6까지 번호가 매겨져 있으며, 각각의 경우 해당 결실의 위치가 오른쪽에 표시되어 있다. UTR: 번역되지 않은 영역; ORF: 오픈 리딩 프레임.
WNV DVG 서열은: 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5) 및 서열 번호: 110 (WNV DVG-6)로 이루어지는 군으로부터 선택된다.
실시예 7: 코로나바이러스(CV) - SARS-CoV-2에 대한 잠재적인 항바이러스 억제제로서의 DVG의 식별
코로나바이러스 SARS-CoV-2 균주(BetaCoV/프랑스/IDF0372/2020)를 Vero E6 세포에서 높은 감염 다중도로 계대시켰다. 간단히 말해서, 세포를 5 x 105 PFU/세포의 초기 MOI로 감염시켰다. 감염 3일 후, 감염된 세포 상층액을 후속 계대에서 감염에 사용하였다. 계대를 10회 반복하였다. 전체 과정은 높은 MOI에서의 계대 후 바이러스 RNA 정제, 심층 시퀀싱 및 결함 있는 바이러스 게놈(DVG)을 식별하기 위한 데이터 분석을 포함하였다.
도 62: SARS-CoV-2 DVG의 심층 시퀀싱 맵. 3개의 DVG가 이들의 풍부도, 계대시 세포 배양에서의 이의 유지 및 크기에 따라 선택되었다. 이 3개의 DVG를 분리하고 시퀀싱했다. SARS-CoV-2 DVG 1, 2 및 3은 서열 번호: 111, 서열 번호: 112 및 서열 번호: 113의 뉴클레오티드 서열을 갖는다. 추가 분석을 위해 이러한 SARS-CoV-2 DVG 중 하나를 선택하였다(서열 번호: 112의 뉴클레오티드 서열을 갖는 SARS-CoV-2 DVG_2).
도 63: Vero E6 세포 및 A549-Ace2 세포(호모 사피엔스, 상피, 폐암)에서의 경쟁 분석. SARS-CoV-2 DVG_2를 T7 프로모터의 제어하에 벡터에 클로닝하였다. SARS-CoV-2 DVG_2 클론에 해당하는 RNA를 mMESSAGE mMACHINE T7 전사 키트(Thermofisher사)에 나타낸 절차에 따라 합성하였다. SARS-CoV-2 DVG_2 클론의 RNA를, 야생형 SARS-CoV-2 바이러스로 세포를 감염시키기 4시간 전 또는 후에 Vero E6 세포 또는 A549-Ace2 세포에 형질감염시켰다. 대조군으로, SARS-CoV-2 DVG_2 클론의 RNA와 동일한 크기의 작은 RNA를 동일한 조건에서 형질감염시켰다. 결과를 플라크 분석에 의해 얻었다. 도 63에 도시된 바와 같이, RNA 대조군의 형질감염은 무처리 세포와 비교하여 Vero E6 세포 및 A549-Ace2 세포 모두에서 SARS-CoV-2 복제 능력에 영향을 미치지 않는다(도 63의 각 그래프 왼쪽에 있는 두 개의 열 참조). SARS-CoV-2 DVG_2 클론의 RNA의 형질감염은 Vero E6 세포에서 SARS-CoV-2 바이러스 복제에 영향을 미치지 않는다. A549-Ace2 세포에서 SARS-CoV-2 바이러스의 복제 능력은, 특히 100 ng의 RNA가 세포에 형질감염되는 경우 SARS-CoV-2 DVG_2 클론의 RNA 형질감염에 의해 영향을 받는다. SARS-CoV-2 DVG_2 클론의 RNA 10 ng으로 A549-Ace2 세포를 후처리함으로써 SARS-CoV-2 역가의 2.5 log 감소가 관찰되었다. SARS-CoV-2 DVG_2 클론의 RNA 100 ng으로 A549-Ace2 세포를 전처리 또는 후처리함으로써 SARS-CoV-2 역가의 2.5 log 감소가 관찰되었다.
SARS-CoV-2 서열은: 서열 번호:111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택된다.
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SEQUENCE LISTING
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<120> DEFECTIVE INTERFERING VIRAL GENOMES
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ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcatgggg 300
cgctctaata cggacatggt gtgaagagtc tactgagcta gttagtagtc ctccggcccc 360
tgaatgcggc taatcccaac tgcggagcac acgcccacaa gccagcgggt agtgtgtcgt 420
aacgggtaac tctgcagcgg aaccgactac tttgggtgtc cgtgtttcct tttatcttta 480
tattggctgc ttatggtgac aattaaagaa ttgttaccat atagctattg gattggccat 540
ccggtgtgca acagagcaat tatttaccaa tttgttggtt ttgtaccatt aaccttgaat 600
tctgtgacca cccttaatta tattttgacc cttaacgcag ctaaacatgg gttcgcaagt 660
gtctacacag cgctccggtt ctcatgaaaa ctcaaactca gccactgagg gttctaccat 720
aaactacacc accatcaatt actacaaaga ctcttatgct gccacagcag gcaaacagag 780
tctcaagcag gatccagaca agtttgcaaa tcctgttaaa gacatcttca ctgaaatggc 840
agcgccattg aagtccccat ccgctgaggc atgtggatac agtgatcgag tggcacaatt 900
aactattggc aactccacca tcaccacgca agaagcggct aacatcatag tcggttatgg 960
tgagtggcct tcttactgct cagattctga cgctacagca gtggataaac caacgcgccc 1020
ggatgtttca gtgaataggt tttacacgtt agacactaaa ttatgggaga aatcgtccaa 1080
gggatggtac tggaagttcc cggatgtgtt aactgaaact ggggtttttg ggcaaaatgc 1140
acaattccac tacctctacc gatcagggtt ctgcatccac gtgcagtgta atgctagtaa 1200
attccaccaa ggagcactcc tagtcgctgt cctaccagag tatgtcattg ggacagtagc 1260
aggcggcaca gggacggaag atacccaccc cccttataag cagacccaac ccggtgccga 1320
tggcttcgag ctgcagcacc cgtacgtgct tgacgctggc atcccaatat cacagttaac 1380
agtgtgccca caccagtgga ttaatttgag gaccaacaat tgtgctacaa taatagtgcc 1440
atacattaac gcactgcctt ttgattctgc cttgaaccat tgcaactttg gcctgctagt 1500
tgtgcctatt agtccactag actacgacca aggagcgacg ccagtaatcc ctataactat 1560
cacattggcc ccaatgtgtt ctgagttcgc aggtcttagg caggcagtca cgcaagggtt 1620
ccctaccgag ctaaaacctg gcacaaatca attcttaacc accgatgatg gtgtctcagc 1680
acctattcta ccaaacttcc accccacccc gtgtatccac atacctggtg aagtgaggaa 1740
tttgctagag ttatgccagg tggaaaccat tctggaggtt aataatgtgc ccacgaatgc 1800
cactagcttg atggagagac tgcgcttccc ggtctcagca caagcaggga aaggtgaact 1860
gtgtgcggtg tttagagccg atcctgggcg aaacggacca tggcaatcca ccttactggg 1920
tcagttgtgc gggtactaca cccaatggtc aggatcattg gaggtcacct tcatgtttac 1980
tggatccttc atggctaccg gcaagatgct catagcctat acaccgccag gaggtcctct 2040
gcccaaggac cgggcgaccg ccatgttggg cacgcacgtc atctgggatt ttgggctgca 2100
atcgtctgtt acccttgtaa taccatggat cagcaacact cattatagag cacatgcccg 2160
agatggagtg tttgactact acaccacagg gttggtcagt atatggtatc agacaaatta 2220
cgtggttcca attggtgcgc ccaacacagc ctatataata gcactagcgg cagcccaaaa 2280
gaacttcact atgaaattgt gcaaggatgc tagtgatatc ttgcagacgg gcaccatcca 2340
gggagatagg gtggcagatg taattgaaag ctccatagga gatagcgtga gcagagccct 2400
cactcacgct ctaccagcac ccacaggtca gaacacacag gtgagcagtc atcgactgga 2460
tacgggcaag gttccagcac tccaagctgc tgaaattgga gcatcatcaa atgctagtga 2520
cgagagtatg attgagacac gctgtgtcct caactcgcac agtacagcag agaccactct 2580
tgatagtttc ttcagcaggg cgggattagt tggagagata gatctccctc ttgagggcac 2640
aactaaccca aatggttatg ccaactggga catagatata acaggttacg cgcaaatgcg 2700
tagaaaggta gagctcttca cctacatgcg ctttgatgca gagttcactt ttgttgcgtg 2760
tacacctacc ggggaagttg ttccacaact gctccaatat atgtttgtgc cacctggagc 2820
cccaaagcca gattctaggg aatcccttgc atggcaaacc gccactaacc cctcagtttt 2880
tgtcaagctg tcagaccctc cagcacaggt ttcagtgcca ttcatgtcac ctgcgagtgc 2940
ttatcaatgg ttttatgacg gatatcccac gttcggagaa cacaaacagg agaaagatct 3000
tgaatatggg gcatgtccta ataacatgat gggcacgttc tcagtgcgga ctgtagggtc 3060
ctccaagtcc aagtaccctc tagtgattag gatttacatg agaatgaagc acgtcagggc 3120
gtggatacct cgcccgatgc gtaaccagaa ctacctattc aaagccaatc caaattatgc 3180
tggcaactcc gttaagccaa ctggtgccag tcgcacagcg atcaccactc ttgggaaatt 3240
tggacaacag tctggggcta tttatgtggg caactttagg gtggtcaacc gacatcttgc 3300
cactcacaat gattgggcaa atcttgtttg ggaagacagc tctcgcgact tgctcgtgtc 3360
atccactacc gcccaaggtt gcgacacgat tgcccgctgc gattgccaga caggggtgta 3420
ctactgtaac tcgatgagaa aacactaccc agttagtttt tcaaaaccca gcctgatcta 3480
tgtagaggct agcgagtatt acccagccag gtaccaatca catctcatgc tcgcacaggg 3540
tcactcagaa cctggtgatt gcggtggtat ccttaggtgc caacatggcg tcgtcggcat 3600
agtgtccact ggtggtaatg ggcttgttgg ctttgcagac gtcagagacc tcttgtggtt 3660
agatgaagaa gccatggaac agggcgtgtc cgactacatc aagggtctcg gggatgcttt 3720
tggaacaggc tttactgacg cagtctcaag ggaggttgaa gctctcaaga actatctcat 3780
agggtctgaa ggagcagttg agaaaatttt gaaaaatcta attaaactaa tctctgcact 3840
ggtgattgtg atcagaagtg attatgatat ggttaccctc actgcgacct tggcgctgat 3900
aggttgtcat ggcagtccgt gggcttggat caaagccaaa acagcctcca tcttaggtat 3960
ccctattgct caaaagcaga gcgcttcctg gctcaagaag ttcaatgata tggccaacgc 4020
cgctaagggg ttagagtggg tttccaacaa gatcagcaaa tttattgatt ggcttaagga 4080
gaagatagta ccagcagcta gggagaaggt tgaattccta aataacttga aacagctgcc 4140
actgctagag aatcagatct caaacttgga acaatctgct gcctcacaag aggaccttga 4200
aatcatgttt gggaatgtat cgtacctagc tcacttctgc cgcaagttcc aaccgctata 4260
cgccacggaa gctaggagag tctatgccct ggagaagagg atgaataact atatgcagtt 4320
caagagcaaa caccgaattg aacctgtatg tctcatcatt aggggctcac caggcactgg 4380
gaagtctcta gccactggta ttattgctcg agcaatcgct gataagtacc actccagcgt 4440
gtactcgctc ccaccagacc cagatcattt tgacggttac aagcaacagg tggttaccgt 4500
gatggatgat ctgtgccaaa accccgacgg aaaggatatg tctttattct gtcaaatggt 4560
atccaccgta gacttcattc caccaatggc ttccctcgag gagaagggag tttccttcac 4620
ctctaagttt gtcatcgcat ccactaatgc cagtaatatc atagtaccaa cagtgtctga 4680
ttccgacgct attcgccgca ggttctacat ggactgtgac attgaagtga cagactcata 4740
caaaacagat ctaggtagac tggatgcagg gcgagccgct aaactgtgct ctgagaacaa 4800
cactgcaaat ttcaaacgtt gtagcccgtt agtgtgcggg aaagctatcc aacttagaga 4860
tagaaagtct aaagtcagat acagtgtgga tacggtggtt tcagaactta ttagggaata 4920
cagcaatagg tccgctattg gcaacacaat cgaggctctt ttccaaggtc cacccaagtt 4980
caggccaatt aggattagcc ttgaagaaaa accagcccca gacgctatta gcgatctcct 5040
tgctagcgta gatagtgaag aagtgcgcca gtactgcagg gatcaaggct ggattattcc 5100
tgaagttccc accaatgtag agcggcacct taatagagcg gtgcttgtca tgcaatccat 5160
cgccacagta gtggcagttg tctcgttggt gtatgtcatc tacaagctct ttgcagggtt 5220
ccagggtgcg tattctggtg ctcctaagca agtgcttaag aaacctgccc ttcgcacagc 5280
aacagtacag ggcccgagcc ttgactttgc tctctcccta ctgagaagga acatcagaca 5340
agttcaaaca gaccaggggc atttcaccat gttgggtgtt agggatcgct tagcagtcct 5400
tccacgtcac tcacaacctg gcaaaactat ttgggttgaa cacaaactcg tgaacgtcct 5460
tgatgcagtt gaactggtgg atgagcaagg agtcaacctg gaattgaccc tcattactct 5520
tgacaccaac gagaagttta gggatattac caagttcatc ccggaaaata ttagcactgc 5580
tagtgatgcc accctagtga tcaacacgga gcatatgcca tcaatgtttg tcccggtggg 5640
tgacgttgtg cagtatggct ttttgaatct cagtggtaag cctacccatc gcaccatgat 5700
gtacaacttt cctactaaag cagggcagtg tggaggagta gtgacatctg ttgggaaggt 5760
tgtcggtatt cacattggtg gcaatggcag acagggtttt tgcgcaggcc tcaaaaggag 5820
ttactttgct agtgaacaag gagagatcca atgggttaag cccaacaaag aaactggaag 5880
actcaacatt aatggaccaa cccgcaccaa attagaacct agtgtattcc atgacatctt 5940
cgagggaaat aaagagccag ctgtcttgca cagtaaagac ccccgacttg aagtagattt 6000
tgaacaggcc ctgttctcta agtatgtggg aaacacacta catgagcctg acgagtacat 6060
caaagaggcg gctcttcatt acgcgaacca attgaagcaa ttagaaatta atacctctca 6120
aatgagcatg gaagaggcct gctacggtac tgagaatctt gaggctattg atcttcacac 6180
tagtgcagga tacccttata gtgccttggg gataaagaaa agagacatct tagaccctac 6240
caccagggac gtgagtaaaa tgaagttcta catggacaag tatggtcttg atcttcctta 6300
ctccacttat gtcaaggacg agctacgctc gattgataaa attaagaaag ggaagtcccg 6360
tctgatcgag gctagtagtc taaatgattc agtgtacctc agaatggctt tcggacattt 6420
gtatgaggct ttccacgcaa atcctgggac aataactgga tcagccgtgg ggtgtaaccc 6480
tgacacattc tggagcaagc tgccaatttt gctccctggt tcactctttg ctttcgacta 6540
ctcaggttat gatgccagcc ttagccctgt ctggttcaga gcattagaat tagttctcag 6600
ggagataggg tatagtgaag aggcggtctc actcattgag ggaatcaacc acacacacca 6660
tgtgtatcgt aataagacct attgtgtgct tggtgggatg ccctcaggtt gttcgggaac 6720
atccattttc aactcaatga tcaacaacat tatcatcaga gcactgctca taaaaacatt 6780
taagggcatt gacttggatg aactcaacat ggtcgcttat ggagacgatg tgctcgctag 6840
ctatcccttc ccaattgatt gcttggaact agcaaagact ggtaaggagt atggtttgac 6900
catgactcct gctgataaat ctccttgctt caatgaggtt aattggggta atgcgacctt 6960
ccttaaaagg ggctttttgc ccgatgaaca gtttccgttc ttgattcacc ccactatgcc 7020
aatgagggag atccatgagt ccattcgatg gaccaaggac gcccgaaaca ctcaagatca 7080
tgtgcggtcc ttgtgcctcc tagcatggca taatggtaaa caagaatatg agaagtttgt 7140
gagcacaatt aggtctgttc cagtgggaag agcgttggct attccaaatt atgaaaacct 7200
tagacgcaat tggctcgagt tattttagag gttatacaca cctcaacccc accagaaatc 7260
tggtcgtgaa tgtgactggt gggggtaaat ttgttataac cagaatagca aaaaaaaaaa 7320
aaaaaaaaaa aaaa 7334
<210> 2
<211> 7321
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 2
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcatacgg 300
acatggtgtg aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa 360
tcccaactgc ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct 420
gcagcggaac cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta 480
tggtgacaat taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca 540
gagcaattat ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc 600
ttaattatat tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc 660
tccggttctc atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc 720
atcaattact acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat 780
ccagacaagt ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag 840
tccccatccg ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac 900
tccaccatca ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct 960
tactgctcag attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg 1020
aataggtttt acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg 1080
aagttcccgg atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac 1140
ctctaccgat cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga 1200
gcactcctag tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg 1260
acggaagata cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg 1320
cagcacccgt acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac 1380
cagtggatta atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca 1440
ctgccttttg attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt 1500
ccactagact acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca 1560
atgtgttctg agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta 1620
aaacctggca caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca 1680
aacttccacc ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta 1740
tgccaggtgg aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg 1800
gagagactgc gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt 1860
agagccgatc ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg 1920
tactacaccc aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg 1980
gctaccggca agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg 2040
gcgaccgcca tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc 2100
cttgtaatac catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt 2160
gactactaca ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt 2220
ggtgcgccca acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg 2280
aaattgtgca aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg 2340
gcagatgtaa ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta 2400
ccagcaccca caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt 2460
ccagcactcc aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt 2520
gagacacgct gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc 2580
agcagggcgg gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat 2640
ggttatgcca actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag 2700
ctcttcacct acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg 2760
gaagttgttc cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat 2820
tctagggaat cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca 2880
gaccctccag cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt 2940
tatgacggat atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca 3000
tgtcctaata acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag 3060
taccctctag tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc 3120
ccgatgcgta accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt 3180
aagccaactg gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct 3240
ggggctattt atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat 3300
tgggcaaatc ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc 3360
caaggttgcg acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg 3420
atgagaaaac actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc 3480
gagtattacc cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct 3540
ggtgattgcg gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt 3600
ggtaatgggc ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc 3660
atggaacagg gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt 3720
actgacgcag tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga 3780
gcagttgaga aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc 3840
agaagtgatt atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc 3900
agtccgtggg cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa 3960
aagcagagcg cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta 4020
gagtgggttt ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca 4080
gcagctaggg agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat 4140
cagatctcaa acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg 4200
aatgtatcgt acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct 4260
aggagagtct atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac 4320
cgaattgaac ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc 4380
actggtatta ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca 4440
ccagacccag atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg 4500
tgccaaaacc ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac 4560
ttcattccac caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc 4620
atcgcatcca ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt 4680
cgccgcaggt tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta 4740
ggtagactgg atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc 4800
aaacgttgta gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa 4860
gtcagataca gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc 4920
gctattggca acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg 4980
attagccttg aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat 5040
agtgaagaag tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc 5100
aatgtagagc ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg 5160
gcagttgtct cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat 5220
tctggtgctc ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc 5280
ccgagccttg actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac 5340
caggggcatt tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca 5400
caacctggca aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa 5460
ctggtggatg agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag 5520
aagtttaggg atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc 5580
ctagtgatca acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag 5640
tatggctttt tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct 5700
actaaagcag ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac 5760
attggtggca atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt 5820
gaacaaggag agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat 5880
ggaccaaccc gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa 5940
gagccagctg tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg 6000
ttctctaagt atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct 6060
cttcattacg cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa 6120
gaggcctgct acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac 6180
ccttatagtg ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg 6240
agtaaaatga agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc 6300
aaggacgagc tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct 6360
agtagtctaa atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc 6420
cacgcaaatc ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg 6480
agcaagctgc caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat 6540
gccagcctta gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat 6600
agtgaagagg cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat 6660
aagacctatt gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac 6720
tcaatgatca acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac 6780
ttggatgaac tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca 6840
attgattgct tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct 6900
gataaatctc cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc 6960
tttttgcccg atgaacagtt tccgttcttg attcacccca ctatgccaat gagggagatc 7020
catgagtcca ttcgatggac caaggacgcc cgaaacactc aagatcatgt gcggtccttg 7080
tgcctcctag catggcataa tggtaaacaa gaatatgaga agtttgtgag cacaattagg 7140
tctgttccag tgggaagagc gttggctatt ccaaattatg aaaaccttag acgcaattgg 7200
ctcgagttat tttagaggtt atacacacct caaccccacc agaaatctgg tcgtgaatgt 7260
gactggtggg ggtaaatttg ttataaccag aatagcaaaa aaaaaaaaaa aaaaaaaaaa 7320
a 7321
<210> 3
<211> 6282
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 3
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcatat gtttgtgcca cctggagccc caaagccaga ttctagggaa tcccttgcat 1800
ggcaaaccgc cactaacccc tcagtttttg tcaagctgtc agaccctcca gcacaggttt 1860
cagtgccatt catgtcacct gcgagtgctt atcaatggtt ttatgacgga tatcccacgt 1920
tcggagaaca caaacaggag aaagatcttg aatatggggc atgtcctaat aacatgatgg 1980
gcacgttctc agtgcggact gtagggtcct ccaagtccaa gtaccctcta gtgattagga 2040
tttacatgag aatgaagcac gtcagggcgt ggatacctcg cccgatgcgt aaccagaact 2100
acctattcaa agccaatcca aattatgctg gcaactccgt taagccaact ggtgccagtc 2160
gcacagcgat caccactctt gggaaatttg gacaacagtc tggggctatt tatgtgggca 2220
actttagggt ggtcaaccga catcttgcca ctcacaatga ttgggcaaat cttgtttggg 2280
aagacagctc tcgcgacttg ctcgtgtcat ccactaccgc ccaaggttgc gacacgattg 2340
cccgctgcga ttgccagaca ggggtgtact actgtaactc gatgagaaaa cactacccag 2400
ttagtttttc aaaacccagc ctgatctatg tagaggctag cgagtattac ccagccaggt 2460
accaatcaca tctcatgctc gcacagggtc actcagaacc tggtgattgc ggtggtatcc 2520
ttaggtgcca acatggcgtc gtcggcatag tgtccactgg tggtaatggg cttgttggct 2580
ttgcagacgt cagagacctc ttgtggttag atgaagaagc catggaacag ggcgtgtccg 2640
actacatcaa gggtctcggg gatgcttttg gaacaggctt tactgacgca gtctcaaggg 2700
aggttgaagc tctcaagaac tatctcatag ggtctgaagg agcagttgag aaaattttga 2760
aaaatctaat taaactaatc tctgcactgg tgattgtgat cagaagtgat tatgatatgg 2820
ttaccctcac tgcgaccttg gcgctgatag gttgtcatgg cagtccgtgg gcttggatca 2880
aagccaaaac agcctccatc ttaggtatcc ctattgctca aaagcagagc gcttcctggc 2940
tcaagaagtt caatgatatg gccaacgccg ctaaggggtt agagtgggtt tccaacaaga 3000
tcagcaaatt tattgattgg cttaaggaga agatagtacc agcagctagg gagaaggttg 3060
aattcctaaa taacttgaaa cagctgccac tgctagagaa tcagatctca aacttggaac 3120
aatctgctgc ctcacaagag gaccttgaaa tcatgtttgg gaatgtatcg tacctagctc 3180
acttctgccg caagttccaa ccgctatacg ccacggaagc taggagagtc tatgccctgg 3240
agaagaggat gaataactat atgcagttca agagcaaaca ccgaattgaa cctgtatgtc 3300
tcatcattag gggctcacca ggcactggga agtctctagc cactggtatt attgctcgag 3360
caatcgctga taagtaccac tccagcgtgt actcgctccc accagaccca gatcattttg 3420
acggttacaa gcaacaggtg gttaccgtga tggatgatct gtgccaaaac cccgacggaa 3480
aggatatgtc tttattctgt caaatggtat ccaccgtaga cttcattcca ccaatggctt 3540
ccctcgagga gaagggagtt tccttcacct ctaagtttgt catcgcatcc actaatgcca 3600
gtaatatcat agtaccaaca gtgtctgatt ccgacgctat tcgccgcagg ttctacatgg 3660
actgtgacat tgaagtgaca gactcataca aaacagatct aggtagactg gatgcagggc 3720
gagccgctaa actgtgctct gagaacaaca ctgcaaattt caaacgttgt agcccgttag 3780
tgtgcgggaa agctatccaa cttagagata gaaagtctaa agtcagatac agtgtggata 3840
cggtggtttc agaacttatt agggaataca gcaataggtc cgctattggc aacacaatcg 3900
aggctctttt ccaaggtcca cccaagttca ggccaattag gattagcctt gaagaaaaac 3960
cagccccaga cgctattagc gatctccttg ctagcgtaga tagtgaagaa gtgcgccagt 4020
actgcaggga tcaaggctgg attattcctg aagttcccac caatgtagag cggcacctta 4080
atagagcggt gcttgtcatg caatccatcg ccacagtagt ggcagttgtc tcgttggtgt 4140
atgtcatcta caagctcttt gcagggttcc agggtgcgta ttctggtgct cctaagcaag 4200
tgcttaagaa acctgccctt cgcacagcaa cagtacaggg cccgagcctt gactttgctc 4260
tctccctact gagaaggaac atcagacaag ttcaaacaga ccaggggcat ttcaccatgt 4320
tgggtgttag ggatcgctta gcagtccttc cacgtcactc acaacctggc aaaactattt 4380
gggttgaaca caaactcgtg aacgtccttg atgcagttga actggtggat gagcaaggag 4440
tcaacctgga attgaccctc attactcttg acaccaacga gaagtttagg gatattacca 4500
agttcatccc ggaaaatatt agcactgcta gtgatgccac cctagtgatc aacacggagc 4560
atatgccatc aatgtttgtc ccggtgggtg acgttgtgca gtatggcttt ttgaatctca 4620
gtggtaagcc tacccatcgc accatgatgt acaactttcc tactaaagca gggcagtgtg 4680
gaggagtagt gacatctgtt gggaaggttg tcggtattca cattggtggc aatggcagac 4740
agggtttttg cgcaggcctc aaaaggagtt actttgctag tgaacaagga gagatccaat 4800
gggttaagcc caacaaagaa actggaagac tcaacattaa tggaccaacc cgcaccaaat 4860
tagaacctag tgtattccat gacatcttcg agggaaataa agagccagct gtcttgcaca 4920
gtaaagaccc ccgacttgaa gtagattttg aacaggccct gttctctaag tatgtgggaa 4980
acacactaca tgagcctgac gagtacatca aagaggcggc tcttcattac gcgaaccaat 5040
tgaagcaatt agaaattaat acctctcaaa tgagcatgga agaggcctgc tacggtactg 5100
agaatcttga ggctattgat cttcacacta gtgcaggata cccttatagt gccttgggga 5160
taaagaaaag agacatctta gaccctacca ccagggacgt gagtaaaatg aagttctaca 5220
tggacaagta tggtcttgat cttccttact ccacttatgt caaggacgag ctacgctcga 5280
ttgataaaat taagaaaggg aagtcccgtc tgatcgaggc tagtagtcta aatgattcag 5340
tgtacctcag aatggctttc ggacatttgt atgaggcttt ccacgcaaat cctgggacaa 5400
taactggatc agccgtgggg tgtaaccctg acacattctg gagcaagctg ccaattttgc 5460
tccctggttc actctttgct ttcgactact caggttatga tgccagcctt agccctgtct 5520
ggttcagagc attagaatta gttctcaggg agatagggta tagtgaagag gcggtctcac 5580
tcattgaggg aatcaaccac acacaccatg tgtatcgtaa taagacctat tgtgtgcttg 5640
gtgggatgcc ctcaggttgt tcgggaacat ccattttcaa ctcaatgatc aacaacatta 5700
tcatcagagc actgctcata aaaacattta agggcattga cttggatgaa ctcaacatgg 5760
tcgcttatgg agacgatgtg ctcgctagct atcccttccc aattgattgc ttggaactag 5820
caaagactgg taaggagtat ggtttgacca tgactcctgc tgataaatct ccttgcttca 5880
atgaggttaa ttggggtaat gcgaccttcc ttaaaagggg ctttttgccc gatgaacagt 5940
ttccgttctt gattcacccc actatgccaa tgagggagat ccatgagtcc attcgatgga 6000
ccaaggacgc ccgaaacact caagatcatg tgcggtcctt gtgcctccta gcatggcata 6060
atggtaaaca agaatatgag aagtttgtga gcacaattag gtctgttcca gtgggaagag 6120
cgttggctat tccaaattat gaaaacctta gacgcaattg gctcgagtta ttttagaggt 6180
tatacacacc tcaaccccac cagaaatctg gtcgtgaatg tgactggtgg gggtaaattt 6240
gttataacca gaatagcaaa aaaaaaaaaa aaaaaaaaaa aa 6282
<210> 4
<211> 6289
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 4
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttatatgtt tgtgccacct ggagccccaa agccagattc tagggaatcc 1800
cttgcatggc aaaccgccac taacccctca gtttttgtca agctgtcaga ccctccagca 1860
caggtttcag tgccattcat gtcacctgcg agtgcttatc aatggtttta tgacggatat 1920
cccacgttcg gagaacacaa acaggagaaa gatcttgaat atggggcatg tcctaataac 1980
atgatgggca cgttctcagt gcggactgta gggtcctcca agtccaagta ccctctagtg 2040
attaggattt acatgagaat gaagcacgtc agggcgtgga tacctcgccc gatgcgtaac 2100
cagaactacc tattcaaagc caatccaaat tatgctggca actccgttaa gccaactggt 2160
gccagtcgca cagcgatcac cactcttggg aaatttggac aacagtctgg ggctatttat 2220
gtgggcaact ttagggtggt caaccgacat cttgccactc acaatgattg ggcaaatctt 2280
gtttgggaag acagctctcg cgacttgctc gtgtcatcca ctaccgccca aggttgcgac 2340
acgattgccc gctgcgattg ccagacaggg gtgtactact gtaactcgat gagaaaacac 2400
tacccagtta gtttttcaaa acccagcctg atctatgtag aggctagcga gtattaccca 2460
gccaggtacc aatcacatct catgctcgca cagggtcact cagaacctgg tgattgcggt 2520
ggtatcctta ggtgccaaca tggcgtcgtc ggcatagtgt ccactggtgg taatgggctt 2580
gttggctttg cagacgtcag agacctcttg tggttagatg aagaagccat ggaacagggc 2640
gtgtccgact acatcaaggg tctcggggat gcttttggaa caggctttac tgacgcagtc 2700
tcaagggagg ttgaagctct caagaactat ctcatagggt ctgaaggagc agttgagaaa 2760
attttgaaaa atctaattaa actaatctct gcactggtga ttgtgatcag aagtgattat 2820
gatatggtta ccctcactgc gaccttggcg ctgataggtt gtcatggcag tccgtgggct 2880
tggatcaaag ccaaaacagc ctccatctta ggtatcccta ttgctcaaaa gcagagcgct 2940
tcctggctca agaagttcaa tgatatggcc aacgccgcta aggggttaga gtgggtttcc 3000
aacaagatca gcaaatttat tgattggctt aaggagaaga tagtaccagc agctagggag 3060
aaggttgaat tcctaaataa cttgaaacag ctgccactgc tagagaatca gatctcaaac 3120
ttggaacaat ctgctgcctc acaagaggac cttgaaatca tgtttgggaa tgtatcgtac 3180
ctagctcact tctgccgcaa gttccaaccg ctatacgcca cggaagctag gagagtctat 3240
gccctggaga agaggatgaa taactatatg cagttcaaga gcaaacaccg aattgaacct 3300
gtatgtctca tcattagggg ctcaccaggc actgggaagt ctctagccac tggtattatt 3360
gctcgagcaa tcgctgataa gtaccactcc agcgtgtact cgctcccacc agacccagat 3420
cattttgacg gttacaagca acaggtggtt accgtgatgg atgatctgtg ccaaaacccc 3480
gacggaaagg atatgtcttt attctgtcaa atggtatcca ccgtagactt cattccacca 3540
atggcttccc tcgaggagaa gggagtttcc ttcacctcta agtttgtcat cgcatccact 3600
aatgccagta atatcatagt accaacagtg tctgattccg acgctattcg ccgcaggttc 3660
tacatggact gtgacattga agtgacagac tcatacaaaa cagatctagg tagactggat 3720
gcagggcgag ccgctaaact gtgctctgag aacaacactg caaatttcaa acgttgtagc 3780
ccgttagtgt gcgggaaagc tatccaactt agagatagaa agtctaaagt cagatacagt 3840
gtggatacgg tggtttcaga acttattagg gaatacagca ataggtccgc tattggcaac 3900
acaatcgagg ctcttttcca aggtccaccc aagttcaggc caattaggat tagccttgaa 3960
gaaaaaccag ccccagacgc tattagcgat ctccttgcta gcgtagatag tgaagaagtg 4020
cgccagtact gcagggatca aggctggatt attcctgaag ttcccaccaa tgtagagcgg 4080
caccttaata gagcggtgct tgtcatgcaa tccatcgcca cagtagtggc agttgtctcg 4140
ttggtgtatg tcatctacaa gctctttgca gggttccagg gtgcgtattc tggtgctcct 4200
aagcaagtgc ttaagaaacc tgcccttcgc acagcaacag tacagggccc gagccttgac 4260
tttgctctct ccctactgag aaggaacatc agacaagttc aaacagacca ggggcatttc 4320
accatgttgg gtgttaggga tcgcttagca gtccttccac gtcactcaca acctggcaaa 4380
actatttggg ttgaacacaa actcgtgaac gtccttgatg cagttgaact ggtggatgag 4440
caaggagtca acctggaatt gaccctcatt actcttgaca ccaacgagaa gtttagggat 4500
attaccaagt tcatcccgga aaatattagc actgctagtg atgccaccct agtgatcaac 4560
acggagcata tgccatcaat gtttgtcccg gtgggtgacg ttgtgcagta tggctttttg 4620
aatctcagtg gtaagcctac ccatcgcacc atgatgtaca actttcctac taaagcaggg 4680
cagtgtggag gagtagtgac atctgttggg aaggttgtcg gtattcacat tggtggcaat 4740
ggcagacagg gtttttgcgc aggcctcaaa aggagttact ttgctagtga acaaggagag 4800
atccaatggg ttaagcccaa caaagaaact ggaagactca acattaatgg accaacccgc 4860
accaaattag aacctagtgt attccatgac atcttcgagg gaaataaaga gccagctgtc 4920
ttgcacagta aagacccccg acttgaagta gattttgaac aggccctgtt ctctaagtat 4980
gtgggaaaca cactacatga gcctgacgag tacatcaaag aggcggctct tcattacgcg 5040
aaccaattga agcaattaga aattaatacc tctcaaatga gcatggaaga ggcctgctac 5100
ggtactgaga atcttgaggc tattgatctt cacactagtg caggataccc ttatagtgcc 5160
ttggggataa agaaaagaga catcttagac cctaccacca gggacgtgag taaaatgaag 5220
ttctacatgg acaagtatgg tcttgatctt ccttactcca cttatgtcaa ggacgagcta 5280
cgctcgattg ataaaattaa gaaagggaag tcccgtctga tcgaggctag tagtctaaat 5340
gattcagtgt acctcagaat ggctttcgga catttgtatg aggctttcca cgcaaatcct 5400
gggacaataa ctggatcagc cgtggggtgt aaccctgaca cattctggag caagctgcca 5460
attttgctcc ctggttcact ctttgctttc gactactcag gttatgatgc cagccttagc 5520
cctgtctggt tcagagcatt agaattagtt ctcagggaga tagggtatag tgaagaggcg 5580
gtctcactca ttgagggaat caaccacaca caccatgtgt atcgtaataa gacctattgt 5640
gtgcttggtg ggatgccctc aggttgttcg ggaacatcca ttttcaactc aatgatcaac 5700
aacattatca tcagagcact gctcataaaa acatttaagg gcattgactt ggatgaactc 5760
aacatggtcg cttatggaga cgatgtgctc gctagctatc ccttcccaat tgattgcttg 5820
gaactagcaa agactggtaa ggagtatggt ttgaccatga ctcctgctga taaatctcct 5880
tgcttcaatg aggttaattg gggtaatgcg accttcctta aaaggggctt tttgcccgat 5940
gaacagtttc cgttcttgat tcaccccact atgccaatga gggagatcca tgagtccatt 6000
cgatggacca aggacgcccg aaacactcaa gatcatgtgc ggtccttgtg cctcctagca 6060
tggcataatg gtaaacaaga atatgagaag tttgtgagca caattaggtc tgttccagtg 6120
ggaagagcgt tggctattcc aaattatgaa aaccttagac gcaattggct cgagttattt 6180
tagaggttat acacacctca accccaccag aaatctggtc gtgaatgtga ctggtggggg 6240
taaatttgtt ataaccagaa tagcaaaaaa aaaaaaaaaa aaaaaaaaa 6289
<210> 5
<211> 6288
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 5
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt ctatatgttt gtgccacctg gagccccaaa gccagattct agggaatccc 1800
ttgcatggca aaccgccact aacccctcag tttttgtcaa gctgtcagac cctccagcac 1860
aggtttcagt gccattcatg tcacctgcga gtgcttatca atggttttat gacggatatc 1920
ccacgttcgg agaacacaaa caggagaaag atcttgaata tggggcatgt cctaataaca 1980
tgatgggcac gttctcagtg cggactgtag ggtcctccaa gtccaagtac cctctagtga 2040
ttaggattta catgagaatg aagcacgtca gggcgtggat acctcgcccg atgcgtaacc 2100
agaactacct attcaaagcc aatccaaatt atgctggcaa ctccgttaag ccaactggtg 2160
ccagtcgcac agcgatcacc actcttggga aatttggaca acagtctggg gctatttatg 2220
tgggcaactt tagggtggtc aaccgacatc ttgccactca caatgattgg gcaaatcttg 2280
tttgggaaga cagctctcgc gacttgctcg tgtcatccac taccgcccaa ggttgcgaca 2340
cgattgcccg ctgcgattgc cagacagggg tgtactactg taactcgatg agaaaacact 2400
acccagttag tttttcaaaa cccagcctga tctatgtaga ggctagcgag tattacccag 2460
ccaggtacca atcacatctc atgctcgcac agggtcactc agaacctggt gattgcggtg 2520
gtatccttag gtgccaacat ggcgtcgtcg gcatagtgtc cactggtggt aatgggcttg 2580
ttggctttgc agacgtcaga gacctcttgt ggttagatga agaagccatg gaacagggcg 2640
tgtccgacta catcaagggt ctcggggatg cttttggaac aggctttact gacgcagtct 2700
caagggaggt tgaagctctc aagaactatc tcatagggtc tgaaggagca gttgagaaaa 2760
ttttgaaaaa tctaattaaa ctaatctctg cactggtgat tgtgatcaga agtgattatg 2820
atatggttac cctcactgcg accttggcgc tgataggttg tcatggcagt ccgtgggctt 2880
ggatcaaagc caaaacagcc tccatcttag gtatccctat tgctcaaaag cagagcgctt 2940
cctggctcaa gaagttcaat gatatggcca acgccgctaa ggggttagag tgggtttcca 3000
acaagatcag caaatttatt gattggctta aggagaagat agtaccagca gctagggaga 3060
aggttgaatt cctaaataac ttgaaacagc tgccactgct agagaatcag atctcaaact 3120
tggaacaatc tgctgcctca caagaggacc ttgaaatcat gtttgggaat gtatcgtacc 3180
tagctcactt ctgccgcaag ttccaaccgc tatacgccac ggaagctagg agagtctatg 3240
ccctggagaa gaggatgaat aactatatgc agttcaagag caaacaccga attgaacctg 3300
tatgtctcat cattaggggc tcaccaggca ctgggaagtc tctagccact ggtattattg 3360
ctcgagcaat cgctgataag taccactcca gcgtgtactc gctcccacca gacccagatc 3420
attttgacgg ttacaagcaa caggtggtta ccgtgatgga tgatctgtgc caaaaccccg 3480
acggaaagga tatgtcttta ttctgtcaaa tggtatccac cgtagacttc attccaccaa 3540
tggcttccct cgaggagaag ggagtttcct tcacctctaa gtttgtcatc gcatccacta 3600
atgccagtaa tatcatagta ccaacagtgt ctgattccga cgctattcgc cgcaggttct 3660
acatggactg tgacattgaa gtgacagact catacaaaac agatctaggt agactggatg 3720
cagggcgagc cgctaaactg tgctctgaga acaacactgc aaatttcaaa cgttgtagcc 3780
cgttagtgtg cgggaaagct atccaactta gagatagaaa gtctaaagtc agatacagtg 3840
tggatacggt ggtttcagaa cttattaggg aatacagcaa taggtccgct attggcaaca 3900
caatcgaggc tcttttccaa ggtccaccca agttcaggcc aattaggatt agccttgaag 3960
aaaaaccagc cccagacgct attagcgatc tccttgctag cgtagatagt gaagaagtgc 4020
gccagtactg cagggatcaa ggctggatta ttcctgaagt tcccaccaat gtagagcggc 4080
accttaatag agcggtgctt gtcatgcaat ccatcgccac agtagtggca gttgtctcgt 4140
tggtgtatgt catctacaag ctctttgcag ggttccaggg tgcgtattct ggtgctccta 4200
agcaagtgct taagaaacct gcccttcgca cagcaacagt acagggcccg agccttgact 4260
ttgctctctc cctactgaga aggaacatca gacaagttca aacagaccag gggcatttca 4320
ccatgttggg tgttagggat cgcttagcag tccttccacg tcactcacaa cctggcaaaa 4380
ctatttgggt tgaacacaaa ctcgtgaacg tccttgatgc agttgaactg gtggatgagc 4440
aaggagtcaa cctggaattg accctcatta ctcttgacac caacgagaag tttagggata 4500
ttaccaagtt catcccggaa aatattagca ctgctagtga tgccacccta gtgatcaaca 4560
cggagcatat gccatcaatg tttgtcccgg tgggtgacgt tgtgcagtat ggctttttga 4620
atctcagtgg taagcctacc catcgcacca tgatgtacaa ctttcctact aaagcagggc 4680
agtgtggagg agtagtgaca tctgttggga aggttgtcgg tattcacatt ggtggcaatg 4740
gcagacaggg tttttgcgca ggcctcaaaa ggagttactt tgctagtgaa caaggagaga 4800
tccaatgggt taagcccaac aaagaaactg gaagactcaa cattaatgga ccaacccgca 4860
ccaaattaga acctagtgta ttccatgaca tcttcgaggg aaataaagag ccagctgtct 4920
tgcacagtaa agacccccga cttgaagtag attttgaaca ggccctgttc tctaagtatg 4980
tgggaaacac actacatgag cctgacgagt acatcaaaga ggcggctctt cattacgcga 5040
accaattgaa gcaattagaa attaatacct ctcaaatgag catggaagag gcctgctacg 5100
gtactgagaa tcttgaggct attgatcttc acactagtgc aggataccct tatagtgcct 5160
tggggataaa gaaaagagac atcttagacc ctaccaccag ggacgtgagt aaaatgaagt 5220
tctacatgga caagtatggt cttgatcttc cttactccac ttatgtcaag gacgagctac 5280
gctcgattga taaaattaag aaagggaagt cccgtctgat cgaggctagt agtctaaatg 5340
attcagtgta cctcagaatg gctttcggac atttgtatga ggctttccac gcaaatcctg 5400
ggacaataac tggatcagcc gtggggtgta accctgacac attctggagc aagctgccaa 5460
ttttgctccc tggttcactc tttgctttcg actactcagg ttatgatgcc agccttagcc 5520
ctgtctggtt cagagcatta gaattagttc tcagggagat agggtatagt gaagaggcgg 5580
tctcactcat tgagggaatc aaccacacac accatgtgta tcgtaataag acctattgtg 5640
tgcttggtgg gatgccctca ggttgttcgg gaacatccat tttcaactca atgatcaaca 5700
acattatcat cagagcactg ctcataaaaa catttaaggg cattgacttg gatgaactca 5760
acatggtcgc ttatggagac gatgtgctcg ctagctatcc cttcccaatt gattgcttgg 5820
aactagcaaa gactggtaag gagtatggtt tgaccatgac tcctgctgat aaatctcctt 5880
gcttcaatga ggttaattgg ggtaatgcga ccttccttaa aaggggcttt ttgcccgatg 5940
aacagtttcc gttcttgatt caccccacta tgccaatgag ggagatccat gagtccattc 6000
gatggaccaa ggacgcccga aacactcaag atcatgtgcg gtccttgtgc ctcctagcat 6060
ggcataatgg taaacaagaa tatgagaagt ttgtgagcac aattaggtct gttccagtgg 6120
gaagagcgtt ggctattcca aattatgaaa accttagacg caattggctc gagttatttt 6180
agaggttata cacacctcaa ccccaccaga aatctggtcg tgaatgtgac tggtgggggt 6240
aaatttgtta taaccagaat agcaaaaaaa aaaaaaaaaa aaaaaaaa 6288
<210> 6
<211> 6288
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 6
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt ctatatgttt gtgccacctg gagccccaaa gccagattct agggaatccc 1800
ttgcatggca aaccgccact aacccctcag tttttgtcaa gctgtcagac cctccagcac 1860
aggtttcagt gccattcatg tcacctgcga gtgcttatca atggttttat gacggatatc 1920
ccacgttcgg agaacacaaa caggagaaag atcttgaata tggggcatgt cctaataaca 1980
tgatgggcac gttctcagtg cggactgtag ggtcctccaa gtccaagtac cctctagtga 2040
ttaggattta catgagaatg aagcacgtca gggcgtggat acctcgcccg atgcgtaacc 2100
agaactacct attcaaagcc aatccaaatt atgctggcaa ctccgttaag ccaactggtg 2160
ccagtcgcac agcgatcacc actcttggga aatttggaca acagtctggg gctatttatg 2220
tgggcaactt tagggtggtc aaccgacatc ttgccactca caatgattgg gcaaatcttg 2280
tttgggaaga cagctctcgc gacttgctcg tgtcatccac taccgcccaa ggttgcgaca 2340
cgattgcccg ctgcgattgc cagacagggg tgtactactg taactcgatg agaaaacact 2400
acccagttag tttttcaaaa cccagcctga tctatgtaga ggctagcgag tattacccag 2460
ccaggtacca atcacatctc atgctcgcac agggtcactc agaacctggt gattgcggtg 2520
gtatccttag gtgccaacat ggcgtcgtcg gcatagtgtc cactggtggt aatgggcttg 2580
ttggctttgc agacgtcaga gacctcttgt ggttagatga agaagccatg gaacagggcg 2640
tgtccgacta catcaagggt ctcggggatg cttttggaac aggctttact gacgcagtct 2700
caagggaggt tgaagctctc aagaactatc tcatagggtc tgaaggagca gttgagaaaa 2760
ttttgaaaaa tctaattaaa ctaatctctg cactggtgat tgtgatcaga agtgattatg 2820
atatggttac cctcactgcg accttggcgc tgataggttg tcatggcagt ccgtgggctt 2880
ggatcaaagc caaaacagcc tccatcttag gtatccctat tgctcaaaag cagagcgctt 2940
cctggctcaa gaagttcaat gatatggcca acgccgctaa ggggttagag tgggtttcca 3000
acaagatcag caaatttatt gattggctta aggagaagat agtaccagca gctagggaga 3060
aggttgaatt cctaaataac ttgaaacagc tgccactgct agagaatcag atctcaaact 3120
tggaacaatc tgctgcctca caagaggacc ttgaaatcat gtttgggaat gtatcgtacc 3180
tagctcactt ctgccgcaag ttccaaccgc tatacgccac ggaagctagg agagtctatg 3240
ccctggagaa gaggatgaat aactatatgc agttcaagag caaacaccga attgaacctg 3300
tatgtctcat cattaggggc tcaccaggca ctgggaagtc tctagccact ggtattattg 3360
ctcgagcaat cgctgataag taccactcca gcgtgtactc gctcccacca gacccagatc 3420
attttgacgg ttacaagcaa caggtggtta ccgtgatgga tgatctgtgc caaaaccccg 3480
acggaaagga tatgtcttta ttctgtcaaa tggtatccac cgtagacttc attccaccaa 3540
tggcttccct cgaggagaag ggagtttcct tcacctctaa gtttgtcatc gcatccacta 3600
atgccagtaa tatcatagta ccaacagtgt ctgattccga cgctattcgc cgcaggttct 3660
acatggactg tgacattgaa gtgacagact catacaaaac agatctaggt agactggatg 3720
cagggcgagc cgctaaactg tgctctgaga acaacactgc aaatttcaaa cgttgtagcc 3780
cgttagtgtg cgggaaagct atccaactta gagatagaaa gtctaaagtc agatacagtg 3840
tggatacggt ggtttcagaa cttattaggg aatacagcaa taggtccgct attggcaaca 3900
caatcgaggc tcttttccaa ggtccaccca agttcaggcc aattaggatt agccttgaag 3960
aaaaaccagc cccagacgct attagcgatc tccttgctag cgtagatagt gaagaagtgc 4020
gccagtactg cagggatcaa ggctggatta ttcctgaagt tcccaccaat gtagagcggc 4080
accttaatag agcggtgctt gtcatgcaat ccatcgccac agtagtggca gttgtctcgt 4140
tggtgtatgt catctacaag ctctttgcag ggttccaggg tgcgtattct ggtgctccta 4200
agcaagtgct taagaaacct gcccttcgca cagcaacagt acagggcccg agccttgact 4260
ttgctctctc cctactgaga aggaacatca gacaagttca aacagaccag gggcatttca 4320
ccatgttggg tgttagggat cgcttagcag tccttccacg tcactcacaa cctggcaaaa 4380
ctatttgggt tgaacacaaa ctcgtgaacg tccttgatgc agttgaactg gtggatgagc 4440
aaggagtcaa cctggaattg accctcatta ctcttgacac caacgagaag tttagggata 4500
ttaccaagtt catcccggaa aatattagca ctgctagtga tgccacccta gtgatcaaca 4560
cggagcatat gccatcaatg tttgtcccgg tgggtgacgt tgtgcagtat ggctttttga 4620
atctcagtgg taagcctacc catcgcacca tgatgtacaa ctttcctact aaagcagggc 4680
agtgtggagg agtagtgaca tctgttggga aggttgtcgg tattcacatt ggtggcaatg 4740
gcagacaggg tttttgcgca ggcctcaaaa ggagttactt tgctagtgaa caaggagaga 4800
tccaatgggt taagcccaac aaagaaactg gaagactcaa cattaatgga ccaacccgca 4860
ccaaattaga acctagtgta ttccatgaca tcttcgaggg aaataaagag ccagctgtct 4920
tgcacagtaa agacccccga cttgaagtag attttgaaca ggccctgttc tctaagtatg 4980
tgggaaacac actacatgag cctgacgagt acatcaaaga ggcggctctt cattacgcga 5040
accaattgaa gcaattagaa attaatacct ctcaaatgag catggaagag gcctgctacg 5100
gtactgagaa tcttgaggct attgatcttc acactagtgc aggataccct tatagtgcct 5160
tggggataaa gaaaagagac atcttagacc ctaccaccag ggacgtgagt aaaatgaagt 5220
tctacatgga caagtatggt cttgatcttc cttactccac ttatgtcaag gacgagctac 5280
gctcgattga taaaattaag aaagggaagt cccgtctgat cgaggctagt agtctaaatg 5340
attcagtgta cctcagaatg gctttcggac atttgtatga ggctttccac gcaaatcctg 5400
ggacaataac tggatcagcc gtggggtgta accctgacac attctggagc aagctgccaa 5460
ttttgctccc tggttcactc tttgctttcg actactcagg ttatgatgcc agccttagcc 5520
ctgtctggtt cagagcatta gaattagttc tcagggagat agggtatagt gaagaggcgg 5580
tctcactcat tgagggaatc aaccacacac accatgtgta tcgtaataag acctattgtg 5640
tgcttggtgg gatgccctca ggttgttcgg gaacatccat tttcaactca atgatcaaca 5700
acattatcat cagagcactg ctcataaaaa catttaaggg cattgacttg gatgaactca 5760
acatggtcgc ttatggagac gatgtgctcg ctagctatcc cttcccaatt gattgcttgg 5820
aactagcaaa gactggtaag gagtatggtt tgaccatgac tcctgctgat aaatctcctt 5880
gcttcaatga ggttaattgg ggtaatgcga ccttccttaa aaggggcttt ttgcccgatg 5940
aacagtttcc gttcttgatt caccccacta tgccaatgag ggagatccat gagtccattc 6000
gatggaccaa ggacgcccga aacactcaag atcatgtgcg gtccttgtgc ctcctagcat 6060
ggcataatgg taaacaagaa tatgagaagt ttgtgagcac aattaggtct gttccagtgg 6120
gaagagcgtt ggctattcca aattatgaaa accttagacg caattggctc gagttatttt 6180
agaggttata cacacctcaa ccccaccaga aatctggtcg tgaatgtgac tggtgggggt 6240
aaatttgtta taaccagaat agcaaaaaaa aaaaaaaaaa aaaaaaaa 6288
<210> 7
<211> 2823
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 7
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat gtgtacctca gaatggcttt cggacatttg tatgaggctt 1920
tccacgcaaa tcctgggaca ataactggat cagccgtggg gtgtaaccct gacacattct 1980
ggagcaagct gccaattttg ctccctggtt cactctttgc tttcgactac tcaggttatg 2040
atgccagcct tagccctgtc tggttcagag cattagaatt agttctcagg gagatagggt 2100
atagtgaaga ggcggtctca ctcattgagg gaatcaacca cacacaccat gtgtatcgta 2160
ataagaccta ttgtgtgctt ggtgggatgc cctcaggttg ttcgggaaca tccattttca 2220
actcaatgat caacaacatt atcatcagag cactgctcat aaaaacattt aagggcattg 2280
acttggatga actcaacatg gtcgcttatg gagacgatgt gctcgctagc tatcccttcc 2340
caattgattg cttggaacta gcaaagactg gtaaggagta tggtttgacc atgactcctg 2400
ctgataaatc tccttgcttc aatgaggtta attggggtaa tgcgaccttc cttaaaaggg 2460
gctttttgcc cgatgaacag tttccgttct tgattcaccc cactatgcca atgagggaga 2520
tccatgagtc cattcgatgg accaaggacg cccgaaacac tcaagatcat gtgcggtcct 2580
tgtgcctcct agcatggcat aatggtaaac aagaatatga gaagtttgtg agcacaatta 2640
ggtctgttcc agtgggaaga gcgttggcta ttccaaatta tgaaaacctt agacgcaatt 2700
ggctcgagtt attttagagg ttatacacac ctcaacccca ccagaaatct ggtcgtgaat 2760
gtgactggtg ggggtaaatt tgttataacc agaatagcaa aaaaaaaaaa aaaaaaaaaa 2820
aaa 2823
<210> 8
<211> 4428
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 8
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtatga ggctttccac gcaaatcctg 3540
ggacaataac tggatcagcc gtggggtgta accctgacac attctggagc aagctgccaa 3600
ttttgctccc tggttcactc tttgctttcg actactcagg ttatgatgcc agccttagcc 3660
ctgtctggtt cagagcatta gaattagttc tcagggagat agggtatagt gaagaggcgg 3720
tctcactcat tgagggaatc aaccacacac accatgtgta tcgtaataag acctattgtg 3780
tgcttggtgg gatgccctca ggttgttcgg gaacatccat tttcaactca atgatcaaca 3840
acattatcat cagagcactg ctcataaaaa catttaaggg cattgacttg gatgaactca 3900
acatggtcgc ttatggagac gatgtgctcg ctagctatcc cttcccaatt gattgcttgg 3960
aactagcaaa gactggtaag gagtatggtt tgaccatgac tcctgctgat aaatctcctt 4020
gcttcaatga ggttaattgg ggtaatgcga ccttccttaa aaggggcttt ttgcccgatg 4080
aacagtttcc gttcttgatt caccccacta tgccaatgag ggagatccat gagtccattc 4140
gatggaccaa ggacgcccga aacactcaag atcatgtgcg gtccttgtgc ctcctagcat 4200
ggcataatgg taaacaagaa tatgagaagt ttgtgagcac aattaggtct gttccagtgg 4260
gaagagcgtt ggctattcca aattatgaaa accttagacg caattggctc gagttatttt 4320
agaggttata cacacctcaa ccccaccaga aatctggtcg tgaatgtgac tggtgggggt 4380
aaatttgtta taaccagaat agcaaaaaaa aaaaaaaaaa aaaaaaaa 4428
<210> 9
<211> 7272
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 9
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatattacca agttcatccc ggaaaatatt agcactgcta 5520
gtgatgccac cctagtgatc aacacggagc atatgccatc aatgtttgtc ccggtgggtg 5580
acgttgtgca gtatggcttt ttgaatctca gtggtaagcc tacccatcgc accatgatgt 5640
acaactttcc tactaaagca gggcagtgtg gaggagtagt gacatctgtt gggaaggttg 5700
tcggtattca cattggtggc aatggcagac agggtttttg cgcaggcctc aaaaggagtt 5760
actttgctag tgaacaagga gagatccaat gggttaagcc caacaaagaa actggaagac 5820
tcaacattaa tggaccaacc cgcaccaaat tagaacctag tgtattccat gacatcttcg 5880
agggaaataa agagccagct gtcttgcaca gtaaagaccc ccgacttgaa gtagattttg 5940
aacaggccct gttctctaag tatgtgggaa acacactaca tgagcctgac gagtacatca 6000
aagaggcggc tcttcattac gcgaaccaat tgaagcaatt agaaattaat acctctcaaa 6060
tgagcatgga agaggcctgc tacggtactg agaatcttga ggctattgat cttcacacta 6120
gtgcaggata cccttatagt gccttgggga taaagaaaag agacatctta gaccctacca 6180
ccagggacgt gagtaaaatg aagttctaca tggacaagta tggtcttgat cttccttact 6240
ccacttatgt caaggacgag ctacgctcga ttgataaaat taagaaaggg aagtcccgtc 6300
tgatcgaggc tagtagtcta aatgattcag tgtacctcag aatggctttc ggacatttgt 6360
atgaggcttt ccacgcaaat cctgggacaa taactggatc agccgtgggg tgtaaccctg 6420
acacattctg gagcaagctg ccaattttgc tccctggttc actctttgct ttcgactact 6480
caggttatga tgccagcctt agccctgtct ggttcagagc attagaatta gttctcaggg 6540
agatagggta tagtgaagag gcggtctcac tcattgaggg aatcaaccac acacaccatg 6600
tgtatcgtaa taagacctat tgtgtgcttg gtgggatgcc ctcaggttgt tcgggaacat 6660
ccattttcaa ctcaatgatc aacaacatta tcatcagagc actgctcata aaaacattta 6720
agggcattga cttggatgaa ctcaacatgg tcgcttatgg agacgatgtg ctcgctagct 6780
atcccttccc aattgattgc ttggaactag caaagactgg taaggagtat ggtttgacca 6840
tgactcctgc tgataaatct ccttgcttca atgaggttaa ttggggtaat gcgaccttcc 6900
ttaaaagggg ctttttgccc gatgaacagt ttccgttctt gattcacccc actatgccaa 6960
tgagggagat ccatgagtcc attcgatgga ccaaggacgc ccgaaacact caagatcatg 7020
tgcggtcctt gtgcctccta gcatggcata atggtaaaca agaatatgag aagtttgtga 7080
gcacaattag gtctgttcca gtgggaagag cgttggctat tccaaattat gaaaacctta 7140
gacgcaattg gctcgagtta ttttagaggt tatacacacc tcaaccccac cagaaatctg 7200
gtcgtgaatg tgactggtgg gggtaaattt gttataacca gaatagcaaa aaaaaaaaaa 7260
aaaaaaaaaa aa 7272
<210> 10
<211> 7165
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 10
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ggcaatggca gacagggttt ttgcgcaggc 5640
ctcaaaagga gttactttgc tagtgaacaa ggagagatcc aatgggttaa gcccaacaaa 5700
gaaactggaa gactcaacat taatggacca acccgcacca aattagaacc tagtgtattc 5760
catgacatct tcgagggaaa taaagagcca gctgtcttgc acagtaaaga cccccgactt 5820
gaagtagatt ttgaacaggc cctgttctct aagtatgtgg gaaacacact acatgagcct 5880
gacgagtaca tcaaagaggc ggctcttcat tacgcgaacc aattgaagca attagaaatt 5940
aatacctctc aaatgagcat ggaagaggcc tgctacggta ctgagaatct tgaggctatt 6000
gatcttcaca ctagtgcagg atacccttat agtgccttgg ggataaagaa aagagacatc 6060
ttagacccta ccaccaggga cgtgagtaaa atgaagttct acatggacaa gtatggtctt 6120
gatcttcctt actccactta tgtcaaggac gagctacgct cgattgataa aattaagaaa 6180
gggaagtccc gtctgatcga ggctagtagt ctaaatgatt cagtgtacct cagaatggct 6240
ttcggacatt tgtatgaggc tttccacgca aatcctggga caataactgg atcagccgtg 6300
gggtgtaacc ctgacacatt ctggagcaag ctgccaattt tgctccctgg ttcactcttt 6360
gctttcgact actcaggtta tgatgccagc cttagccctg tctggttcag agcattagaa 6420
ttagttctca gggagatagg gtatagtgaa gaggcggtct cactcattga gggaatcaac 6480
cacacacacc atgtgtatcg taataagacc tattgtgtgc ttggtgggat gccctcaggt 6540
tgttcgggaa catccatttt caactcaatg atcaacaaca ttatcatcag agcactgctc 6600
ataaaaacat ttaagggcat tgacttggat gaactcaaca tggtcgctta tggagacgat 6660
gtgctcgcta gctatccctt cccaattgat tgcttggaac tagcaaagac tggtaaggag 6720
tatggtttga ccatgactcc tgctgataaa tctccttgct tcaatgaggt taattggggt 6780
aatgcgacct tccttaaaag gggctttttg cccgatgaac agtttccgtt cttgattcac 6840
cccactatgc caatgaggga gatccatgag tccattcgat ggaccaagga cgcccgaaac 6900
actcaagatc atgtgcggtc cttgtgcctc ctagcatggc ataatggtaa acaagaatat 6960
gagaagtttg tgagcacaat taggtctgtt ccagtgggaa gagcgttggc tattccaaat 7020
tatgaaaacc ttagacgcaa ttggctcgag ttattttaga ggttatacac acctcaaccc 7080
caccagaaat ctggtcgtga atgtgactgg tgggggtaaa tttgttataa ccagaatagc 7140
aaaaaaaaaa aaaaaaaaaa aaaaa 7165
<210> 11
<211> 7164
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 11
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca gcaatggcag acagggtttt tgcgcaggcc 5640
tcaaaaggag ttactttgct agtgaacaag gagagatcca atgggttaag cccaacaaag 5700
aaactggaag actcaacatt aatggaccaa cccgcaccaa attagaacct agtgtattcc 5760
atgacatctt cgagggaaat aaagagccag ctgtcttgca cagtaaagac ccccgacttg 5820
aagtagattt tgaacaggcc ctgttctcta agtatgtggg aaacacacta catgagcctg 5880
acgagtacat caaagaggcg gctcttcatt acgcgaacca attgaagcaa ttagaaatta 5940
atacctctca aatgagcatg gaagaggcct gctacggtac tgagaatctt gaggctattg 6000
atcttcacac tagtgcagga tacccttata gtgccttggg gataaagaaa agagacatct 6060
tagaccctac caccagggac gtgagtaaaa tgaagttcta catggacaag tatggtcttg 6120
atcttcctta ctccacttat gtcaaggacg agctacgctc gattgataaa attaagaaag 6180
ggaagtcccg tctgatcgag gctagtagtc taaatgattc agtgtacctc agaatggctt 6240
tcggacattt gtatgaggct ttccacgcaa atcctgggac aataactgga tcagccgtgg 6300
ggtgtaaccc tgacacattc tggagcaagc tgccaatttt gctccctggt tcactctttg 6360
ctttcgacta ctcaggttat gatgccagcc ttagccctgt ctggttcaga gcattagaat 6420
tagttctcag ggagataggg tatagtgaag aggcggtctc actcattgag ggaatcaacc 6480
acacacacca tgtgtatcgt aataagacct attgtgtgct tggtgggatg ccctcaggtt 6540
gttcgggaac atccattttc aactcaatga tcaacaacat tatcatcaga gcactgctca 6600
taaaaacatt taagggcatt gacttggatg aactcaacat ggtcgcttat ggagacgatg 6660
tgctcgctag ctatcccttc ccaattgatt gcttggaact agcaaagact ggtaaggagt 6720
atggtttgac catgactcct gctgataaat ctccttgctt caatgaggtt aattggggta 6780
atgcgacctt ccttaaaagg ggctttttgc ccgatgaaca gtttccgttc ttgattcacc 6840
ccactatgcc aatgagggag atccatgagt ccattcgatg gaccaaggac gcccgaaaca 6900
ctcaagatca tgtgcggtcc ttgtgcctcc tagcatggca taatggtaaa caagaatatg 6960
agaagtttgt gagcacaatt aggtctgttc cagtgggaag agcgttggct attccaaatt 7020
atgaaaacct tagacgcaat tggctcgagt tattttagag gttatacaca cctcaacccc 7080
accagaaatc tggtcgtgaa tgtgactggt gggggtaaat ttgttataac cagaatagca 7140
aaaaaaaaaa aaaaaaaaaa aaaa 7164
<210> 12
<211> 7356
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 12
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tgtggaggag 5760
tagtgacatc tgttgggaag gttgtcggta ttcacattgg tggcaatggc agacagggtt 5820
tttgcgcagg cctcaaaagg agttactttg ctagtgaaca aggagagatc caatgggtta 5880
agcccaacaa agaaactgga agactcaaca ttaatggacc aacccgcacc aaattagaac 5940
ctagtgtatt ccatgacatc ttcgagggaa ataaagagcc agctgtcttg cacagtaaag 6000
acccccgact tgaagtagat tttgaacagg ccctgttctc taagtatgtg ggaaacacac 6060
tacatgagcc tgacgagtac atcaaagagg cggctcttca ttacgcgaac caattgaagc 6120
aattagaaat taatacctct caaatgagca tggaagaggc ctgctacggt actgagaatc 6180
ttgaggctat tgatcttcac actagtgcag gataccctta tagtgccttg gggataaaga 6240
aaagagacat cttagaccct accaccaggg acgtgagtaa aatgaagttc tacatggaca 6300
agtatggtct tgatcttcct tactccactt atgtcaagga cgagctacgc tcgattgata 6360
aaattaagaa agggaagtcc cgtctgatcg aggctagtag tctaaatgat tcagtgtacc 6420
tcagaatggc tttcggacat ttgtatgagg ctttccacgc aaatcctggg acaataactg 6480
gatcagccgt ggggtgtaac cctgacacat tctggagcaa gctgccaatt ttgctccctg 6540
gttcactctt tgctttcgac tactcaggtt atgatgccag ccttagccct gtctggttca 6600
gagcattaga attagttctc agggagatag ggtatagtga agaggcggtc tcactcattg 6660
agggaatcaa ccacacacac catgtgtatc gtaataagac ctattgtgtg cttggtggga 6720
tgccctcagg ttgttcggga acatccattt tcaactcaat gatcaacaac attatcatca 6780
gagcactgct cataaaaaca tttaagggca ttgacttgga tgaactcaac atggtcgctt 6840
atggagacga tgtgctcgct agctatccct tcccaattga ttgcttggaa ctagcaaaga 6900
ctggtaagga gtatggtttg accatgactc ctgctgataa atctccttgc ttcaatgagg 6960
ttaattgggg taatgcgacc ttccttaaaa ggggcttttt gcccgatgaa cagtttccgt 7020
tcttgattca ccccactatg ccaatgaggg agatccatga gtccattcga tggaccaagg 7080
acgcccgaaa cactcaagat catgtgcggt ccttgtgcct cctagcatgg cataatggta 7140
aacaagaata tgagaagttt gtgagcacaa ttaggtctgt tccagtggga agagcgttgg 7200
ctattccaaa ttatgaaaac cttagacgca attggctcga gttattttag aggttataca 7260
cacctcaacc ccaccagaaa tctggtcgtg aatgtgactg gtgggggtaa atttgttata 7320
accagaatag caaaaaaaaa aaaaaaaaaa aaaaaa 7356
<210> 13
<211> 7397
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 13
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gaatgaagtt ctacatggac aagtatggtc ttgatcttcc 6360
ttactccact tatgtcaagg acgagctacg ctcgattgat aaaattaaga aagggaagtc 6420
ccgtctgatc gaggctagta gtctaaatga ttcagtgtac ctcagaatgg ctttcggaca 6480
tttgtatgag gctttccacg caaatcctgg gacaataact ggatcagccg tggggtgtaa 6540
ccctgacaca ttctggagca agctgccaat tttgctccct ggttcactct ttgctttcga 6600
ctactcaggt tatgatgcca gccttagccc tgtctggttc agagcattag aattagttct 6660
cagggagata gggtatagtg aagaggcggt ctcactcatt gagggaatca accacacaca 6720
ccatgtgtat cgtaataaga cctattgtgt gcttggtggg atgccctcag gttgttcggg 6780
aacatccatt ttcaactcaa tgatcaacaa cattatcatc agagcactgc tcataaaaac 6840
atttaagggc attgacttgg atgaactcaa catggtcgct tatggagacg atgtgctcgc 6900
tagctatccc ttcccaattg attgcttgga actagcaaag actggtaagg agtatggttt 6960
gaccatgact cctgctgata aatctccttg cttcaatgag gttaattggg gtaatgcgac 7020
cttccttaaa aggggctttt tgcccgatga acagtttccg ttcttgattc accccactat 7080
gccaatgagg gagatccatg agtccattcg atggaccaag gacgcccgaa acactcaaga 7140
tcatgtgcgg tccttgtgcc tcctagcatg gcataatggt aaacaagaat atgagaagtt 7200
tgtgagcaca attaggtctg ttccagtggg aagagcgttg gctattccaa attatgaaaa 7260
ccttagacgc aattggctcg agttatttta gaggttatac acacctcaac cccaccagaa 7320
atctggtcgt gaatgtgact ggtgggggta aatttgttat aaccagaata gcaaaaaaaa 7380
aaaaaaaaaa aaaaaaa 7397
<210> 14
<211> 7395
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 14
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gagaagttct acatggacaa gtatggtctt gatcttcctt 6360
actccactta tgtcaaggac gagctacgct cgattgataa aattaagaaa gggaagtccc 6420
gtctgatcga ggctagtagt ctaaatgatt cagtgtacct cagaatggct ttcggacatt 6480
tgtatgaggc tttccacgca aatcctggga caataactgg atcagccgtg gggtgtaacc 6540
ctgacacatt ctggagcaag ctgccaattt tgctccctgg ttcactcttt gctttcgact 6600
actcaggtta tgatgccagc cttagccctg tctggttcag agcattagaa ttagttctca 6660
gggagatagg gtatagtgaa gaggcggtct cactcattga gggaatcaac cacacacacc 6720
atgtgtatcg taataagacc tattgtgtgc ttggtgggat gccctcaggt tgttcgggaa 6780
catccatttt caactcaatg atcaacaaca ttatcatcag agcactgctc ataaaaacat 6840
ttaagggcat tgacttggat gaactcaaca tggtcgctta tggagacgat gtgctcgcta 6900
gctatccctt cccaattgat tgcttggaac tagcaaagac tggtaaggag tatggtttga 6960
ccatgactcc tgctgataaa tctccttgct tcaatgaggt taattggggt aatgcgacct 7020
tccttaaaag gggctttttg cccgatgaac agtttccgtt cttgattcac cccactatgc 7080
caatgaggga gatccatgag tccattcgat ggaccaagga cgcccgaaac actcaagatc 7140
atgtgcggtc cttgtgcctc ctagcatggc ataatggtaa acaagaatat gagaagtttg 7200
tgagcacaat taggtctgtt ccagtgggaa gagcgttggc tattccaaat tatgaaaacc 7260
ttagacgcaa ttggctcgag ttattttaga ggttatacac acctcaaccc caccagaaat 7320
ctggtcgtga atgtgactgg tgggggtaaa tttgttataa ccagaatagc aaaaaaaaaa 7380
aaaaaaaaaa aaaaa 7395
<210> 15
<211> 7380
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 15
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcatg tgtgcttggt gggatgccct caggttgttc gggaacatcc attttcaact 6780
caatgatcaa caacattatc atcagagcac tgctcataaa aacatttaag ggcattgact 6840
tggatgaact caacatggtc gcttatggag acgatgtgct cgctagctat cccttcccaa 6900
ttgattgctt ggaactagca aagactggta aggagtatgg tttgaccatg actcctgctg 6960
ataaatctcc ttgcttcaat gaggttaatt ggggtaatgc gaccttcctt aaaaggggct 7020
ttttgcccga tgaacagttt ccgttcttga ttcaccccac tatgccaatg agggagatcc 7080
atgagtccat tcgatggacc aaggacgccc gaaacactca agatcatgtg cggtccttgt 7140
gcctcctagc atggcataat ggtaaacaag aatatgagaa gtttgtgagc acaattaggt 7200
ctgttccagt gggaagagcg ttggctattc caaattatga aaaccttaga cgcaattggc 7260
tcgagttatt ttagaggtta tacacacctc aaccccacca gaaatctggt cgtgaatgtg 7320
actggtgggg gtaaatttgt tataaccaga atagcaaaaa aaaaaaaaaa aaaaaaaaaa 7380
<210> 16
<211> 7385
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 16
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactaaa tctccttgct tcaatgaggt taattggggt aatgcgacct tccttaaaag 7020
gggctttttg cccgatgaac agtttccgtt cttgattcac cccactatgc caatgaggga 7080
gatccatgag tccattcgat ggaccaagga cgcccgaaac actcaagatc atgtgcggtc 7140
cttgtgcctc ctagcatggc ataatggtaa acaagaatat gagaagtttg tgagcacaat 7200
taggtctgtt ccagtgggaa gagcgttggc tattccaaat tatgaaaacc ttagacgcaa 7260
ttggctcgag ttattttaga ggttatacac acctcaaccc caccagaaat ctggtcgtga 7320
atgtgactgg tgggggtaaa tttgttataa ccagaatagc aaaaaaaaaa aaaaaaaaaa 7380
aaaaa 7385
<210> 17
<211> 7383
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 17
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaacaatc tccttgcttc aatgaggtta attggggtaa tgcgaccttc cttaaaaggg 7020
gctttttgcc cgatgaacag tttccgttct tgattcaccc cactatgcca atgagggaga 7080
tccatgagtc cattcgatgg accaaggacg cccgaaacac tcaagatcat gtgcggtcct 7140
tgtgcctcct agcatggcat aatggtaaac aagaatatga gaagtttgtg agcacaatta 7200
ggtctgttcc agtgggaaga gcgttggcta ttccaaatta tgaaaacctt agacgcaatt 7260
ggctcgagtt attttagagg ttatacacac ctcaacccca ccagaaatct ggtcgtgaat 7320
gtgactggtg ggggtaaatt tgttataacc agaatagcaa aaaaaaaaaa aaaaaaaaaa 7380
aaa 7383
<210> 18
<211> 7407
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 18
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct gataaatctc 7020
cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc tttttgcccg 7080
atgaacagtt tccgttctgg gagatccatg agtccattcg atggaccaag gacgcccgaa 7140
acactcaaga tcatgtgcgg tccttgtgcc tcctagcatg gcataatggt aaacaagaat 7200
atgagaagtt tgtgagcaca attaggtctg ttccagtggg aagagcgttg gctattccaa 7260
attatgaaaa ccttagacgc aattggctcg agttatttta gaggttatac acacctcaac 7320
cccaccagaa atctggtcgt gaatgtgact ggtgggggta aatttgttat aaccagaata 7380
gcaaaaaaaa aaaaaaaaaa aaaaaaa 7407
<210> 19
<211> 7396
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 19
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct gataaatctc 7020
cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc tttttgcccg 7080
atgaacagtt tccgttcttg attcacccca ctatgccaat gagggagatc catgagtcca 7140
ttcgatggac caaggacgcc cgaaacatgg cataatggta aacaagaata tgagaagttt 7200
gtgagcacaa ttaggtctgt tccagtggga agagcgttgg ctattccaaa ttatgaaaac 7260
cttagacgca attggctcga gttattttag aggttataca cacctcaacc ccaccagaaa 7320
tctggtcgtg aatgtgactg gtgggggtaa atttgttata accagaatag caaaaaaaaa 7380
aaaaaaaaaa aaaaaa 7396
<210> 20
<211> 7395
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 20
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct gataaatctc 7020
cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc tttttgcccg 7080
atgaacagtt tccgttcttg attcacccca ctatgccaat gagggagatc catgagtcca 7140
ttcgatggac caaggacgcc cgaaaatggc ataatggtaa acaagaatat gagaagtttg 7200
tgagcacaat taggtctgtt ccagtgggaa gagcgttggc tattccaaat tatgaaaacc 7260
ttagacgcaa ttggctcgag ttattttaga ggttatacac acctcaaccc caccagaaat 7320
ctggtcgtga atgtgactgg tgggggtaaa tttgttataa ccagaatagc aaaaaaaaaa 7380
aaaaaaaaaa aaaaa 7395
<210> 21
<211> 7377
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 21
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct gataaatctc 7020
cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc tttttgcccg 7080
atgaacagtt tccgttcttg attcacccca ctatgccaat gagggagatc catgagtcca 7140
ttcgatggac caaggacgcc cgaaacactc aagatcatgt gcggtccttg tgcctcctag 7200
catggcataa tggtaaacaa gaatatgaga agtttgtgaa ccttagacgc aattggctcg 7260
agttatttta gaggttatac acacctcaac cccaccagaa atctggtcgt gaatgtgact 7320
ggtgggggta aatttgttat aaccagaata gcaaaaaaaa aaaaaaaaaa aaaaaaa 7377
<210> 22
<211> 927
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 22
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtccaa aaaaccccac gcgcttggaa gcgcaggatg ggaaaagaag gtggcgacct 720
tccccaccct tcaatctggg gcctgaactg gagactagct gtgaatctcc agcagaggga 780
ctagtggtta gaggagaccc cccggaaaac gcaaaacagc atattgacgc tgggaaagac 840
cagagactcc atgagtttcc accacgctgg ccgccaggca cagatcgccg aacttcggcg 900
gccggtgtgg ggaaatccat ggtttct 927
<210> 23
<211> 1170
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 23
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagctgc ctgtcttgca 300
aaatcatatg cgcagatgtg gcagctcctt tatttccaca gaagagacct tcgactgatg 360
gctaatgcca tttgctcggc tgtgccagtt gactgggtac caactgggag aaccacctgg 420
tcaatccatg gaaagggaga atggatgacc actgaggaca tgctcatggt gtggaataga 480
gtgtggattg aggagaacga ccatatggag gacaagactc ctgtaacaaa atggacagac 540
attccctatc taggaaaaag ggaggactta tggtgtggat cccttatagg gcacagaccc 600
cgcaccactt gggctgaaaa catcaaagac acagtcaaca tggtgcgcag gatcataggt 660
gatgaagaaa agtacatgga ctatctatcc acccaagtcc gctacttggg tgaggaaggg 720
tccacacccg gagtgttgta agcaccaatt ttagtgttgt caggcctgct agtcagccac 780
agtttgggga aagctgtgca gcctgtaacc cccccaggag aagctgggaa accaagctca 840
tagtcaggcc gagaacgcca tggcacggaa gaagccatgc tgcctgtgag cccctcagag 900
gacactgagt caaaaaaccc cacgcgcttg gaagcgcagg atgggaaaag aaggtggcga 960
ccttccccac ccttcaatct ggggcctgaa ctggagacta gctgtgaatc tccagcagag 1020
ggactagtgg ttagaggaga ccccccggaa aacgcaaaac agcatattga cgctgggaaa 1080
gaccagagac tccatgagtt tccaccacgc tggccgccag gcacagatcg ccgaacttcg 1140
gcggccggtg tggggaaatc catggtttct 1170
<210> 24
<211> 1296
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 24
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgaaaagta catggactat ctatccaccc aagtccgcta cttgggtgag 840
gaagggtcca cacccggagt gttgtaagca ccaattttag tgttgtcagg cctgctagtc 900
agccacagtt tggggaaagc tgtgcagcct gtaacccccc caggagaagc tgggaaacca 960
agctcatagt caggccgaga acgccatggc acggaagaag ccatgctgcc tgtgagcccc 1020
tcagaggaca ctgagtcaaa aaaccccacg cgcttggaag cgcaggatgg gaaaagaagg 1080
tggcgacctt ccccaccctt caatctgggg cctgaactgg agactagctg tgaatctcca 1140
gcagagggac tagtggttag aggagacccc ccggaaaacg caaaacagca tattgacgct 1200
gggaaagacc agagactcca tgagtttcca ccacgctggc cgccaggcac agatcgccga 1260
acttcggcgg ccggtgtggg gaaatccatg gtttct 1296
<210> 25
<211> 1731
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 25
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg agtgtggatt gaggagaacg accatatgga ggacaagact 1080
cctgtaacaa aatggacaga cattccctat ctaggaaaaa gggaggactt atggtgtgga 1140
tcccttatag ggcacagacc ccgcaccact tgggctgaaa acatcaaaga cacagtcaac 1200
atggtgcgca ggatcatagg tgatgaagaa aagtacatgg actatctatc cacccaagtc 1260
cgctacttgg gtgaggaagg gtccacaccc ggagtgttgt aagcaccaat tttagtgttg 1320
tcaggcctgc tagtcagcca cagtttgggg aaagctgtgc agcctgtaac ccccccagga 1380
gaagctggga aaccaagctc atagtcaggc cgagaacgcc atggcacgga agaagccatg 1440
ctgcctgtga gcccctcaga ggacactgag tcaaaaaacc ccacgcgctt ggaagcgcag 1500
gatgggaaaa gaaggtggcg accttcccca cccttcaatc tggggcctga actggagact 1560
agctgtgaat ctccagcaga gggactagtg gttagaggag accccccgga aaacgcaaaa 1620
cagcatattg acgctgggaa agaccagaga ctccatgagt ttccaccacg ctggccgcca 1680
ggcacagatc gccgaacttc ggcggccggt gtggggaaat ccatggtttc t 1731
<210> 26
<211> 1873
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 26
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1080
acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga 1140
ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1200
aacacaaggt gaggcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1260
attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1320
atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1380
ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttgtcaatga 1440
tacaggatat gaaactgtgt tgtcaggcct gctagtcagc cacagtttgg ggaaagctgt 1500
gcagcctgta acccccccag gagaagctgg gaaaccaagc tcatagtcag gccgagaacg 1560
ccatggcacg gaagaagcca tgctgcctgt gagcccctca gaggacactg agtcaaaaaa 1620
ccccacgcgc ttggaagcgc aggatgggaa aagaaggtgg cgaccttccc cacccttcaa 1680
tctggggcct gaactggaga ctagctgtga atctccagca gagggactag tggttagagg 1740
agaccccccg gaaaacgcaa aacagcatat tgacgctggg aaagaccaga gactccatga 1800
gtttccacca cgctggccgc caggcacaga tcgccgaact tcggcggccg gtgtggggaa 1860
atccatggtt tct 1873
<210> 27
<211> 4862
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 27
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1080
acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga 1140
ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1200
aacacaaggt gaggcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1260
attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1320
atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1380
ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttgtcaatga 1440
tacaggatat gaaactgacg aaaatagagc gaaagtcgag gttacgccta attcaccaag 1500
agcggaagca accttgggag gctttggaag cttaggactt gactgtgaac caaggacagg 1560
ccttgacttt tcagatctgt attacctgac catgaacaat aagcattggt tggtgcacaa 1620
agagtggttt catgacatcc cattgccttg gcatgctggg gcagacaccg gaactccaca 1680
ctggaacaac aaagaggcat tggtagaatt caaggatgcc cacgccaaga ggcaaaccgt 1740
cgtcgttctg gggagccagg aaggagccgt tcacacggct ctcgctggag ctctagaggc 1800
tgagatggat ggtgcaaagg gaaagctgtt ctctggccac ttgaaatgcc gcctaaaaat 1860
ggacaagctt agattgaagg gcgtgtcata ttccttgtgc actgcggcat tcacattcac 1920
caaggtccca gctgaaacac tgcatggaac agtcacagtg gaggtgcagt atgcagggac 1980
agatggaccc tgcaagatcc cagtccagat ggcggtggac atgcagaccc tgaccccagt 2040
tggaaggctg ataaccgcca accccgtgat tactgaaagc actgagaact caaagatgat 2100
gttggagctt gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa 2160
aatcacccac cactggcata ggagtggtag caccatcgga aaggcatttg aggccactgt 2220
gagaggcgcc aagagaatgg cagtcctggg ggatacagcc tgggacttcg gatcagtcgg 2280
gggtgtgttc aactcactgg gtaagggcat tcaccagatt tttggagcag ccttcaaatc 2340
actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tagtgtggtt 2400
aggtttgaac acaaagaatg gatctatctc cctcacatgc ttggccctgg ggggagtgat 2460
gatcttcctc tccacggctg tttctgctga tgtggggtgc tcagtggact tctcaaaaaa 2520
ggaaacgaga tgtggcacgg gggtattcat ctataatgat gttgaagcct ggagggaccg 2580
gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcctggga 2640
agaggggatc tgtgggatct catccgtttc aagaatggaa aacatcatgt ggaaatcagt 2700
agaaggggag ctcaatgcta tcctagagga gaatggagtt caactgacag ttgttgtggg 2760
atctgtaaaa aaccccatgt ggagaggtcc acaaagattg ccagtgcctg tgaatgagct 2820
gccccatggc tggaaagcct gggggaaatc gtattttgtt agggcggcaa agaccaacaa 2880
cagttttgtt gtcgacggtg acacactgaa ggaatgtccg cttgagcaca gagcatggaa 2940
tagttttctt gtggaggatc acgggtttgg agtcttccac accagtgtct ggcttaaggt 3000
cagagaagat tactcattag aatgtgaccc agccgtcata ggaacagctg ttaagggaag 3060
ggaggccgcg cacagtgatc tgggctattg gaaaaagaga aaagaagcaa ggagagttcg 3120
ggaaagcaaa aggtagccgc gccatctggt acatgtggtt gggagccaga ttcttggagt 3180
ttgaagccct tggattcttg aacgaggacc attggatggg aagagaaaac tcaggaggtg 3240
gagtcgaagg gttaggattg caaagacttg gatacattct agaagaaatg aatcgggcac 3300
caggaggaaa gatgtacgca gatgacactg ctggctggga cacccgcatt agtaagtttg 3360
atctggagaa tgaagctctg attaccaacc aaatggagga agggcacaga actctggcgt 3420
tggccgtgat taaatacaca taccaaaaca aagtggtgaa ggttctcaga ccagctgaag 3480
gaggaaaaac agttatggac atcatttcaa gacaagacca gagagggagt ggacaagttg 3540
tcacttatgc tctcaacaca ttcaccaact tggtggtgca gcttatccgg aacatggaag 3600
ctgaggaagt gttagagatg caagacttat ggttgttgag gaagccagag aaagtgacca 3660
gatggttgca gagcaatgga tgggatagac tcaaacgaat ggcggtcagt ggagatgact 3720
gcgttgtgaa gccaatcgat gataggtttg cacatgccct caggttcttg aatgacatgg 3780
gaaaagttag gaaagacaca caggagtgga aaccctcgac tggatggagc aattgggaag 3840
aagtcccgtt ctgctcccac cacttcaaca agctgtacct caaggatggg agatccattg 3900
tggtcccttg ccgccaccaa gatgaactga ttggccgagc tcgcgtctca ccaggggcag 3960
gatggagcat ccgggagact gcctgtcttg caaaatcata tgcgcagatg tggcagctcc 4020
tttatttcca cagaagagac cttcgactga tggctaatgc catttgctcg gctgtgccag 4080
ttgactgggt accaactggg agaaccacct ggtcaatcca tggaaaggga gaatggatga 4140
ccactgagga catgctcatg gtgtggaata gagtgtggat tgaggagaac gaccatatgg 4200
aggacaagac tcctgtaaca aaatggacag acattcccta tctaggaaaa agggaggact 4260
tatggtgtgg atcccttata gggcacagac cccgcaccac ttgggctgaa aacatcaaag 4320
acacagtcaa catggtgcgc aggatcatag gtgatgaaga aaagtacatg gactatctat 4380
ccacccaagt ccgctacttg ggtgaggaag ggtccacacc cggagtgttg taagcaccaa 4440
ttttagtgtt gtcaggcctg ctagtcagcc acagtttggg gaaagctgtg cagcctgtaa 4500
cccccccagg agaagctggg aaaccaagct catagtcagg ccgagaacgc catggcacgg 4560
aagaagccat gctgcctgtg agcccctcag aggacactga gtcaaaaaac cccacgcgct 4620
tggaagcgca ggatgggaaa agaaggtggc gaccttcccc acccttcaat ctggggcctg 4680
aactggagac tagctgtgaa tctccagcag agggactagt ggttagagga gaccccccgg 4740
aaaacgcaaa acagcatatt gacgctggga aagaccagag actccatgag tttccaccac 4800
gctggccgcc aggcacagat cgccgaactt cggcggccgg tgtggggaaa tccatggttt 4860
ct 4862
<210> 28
<211> 6513
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 28
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagtgaag 360
aaaggagaga ccacagatgg agtgtacaga gtgatgactc gcagactgct aggttcaaca 420
caggttggag tgggagtcat gcaagaggga gtcttccaca ccatgtggca cgttacaaaa 480
ggagccgcac tgaggagcgg tgagggaaga cttgatccat actgggggga tgtcaagcag 540
gacttggtgt catactgtgg gccttggaag ttggatgcag cttgggatgg actcagcgag 600
gtacagcttt tggccgtacc tcccggagag agggccagaa acattcagac cctgcctgga 660
atattcaaga caaaggacgg ggacatcgga gcagttgctc tggactaccc tgcagggacc 720
tcaggatctc cgatcctaga caaatgtgga agagtgatag gactctatgg caatggggtt 780
gtgatcaaga atggaagcta tgttagtgct ataacccagg gaaagaggga ggaggagact 840
ccggttgaat gtttcgaacc ctcgatgctg aagaagaagc agctaactgt cttggatctg 900
catccaggag ccggaaaaac caggagagtt cttcctgaaa tagtccgtga agccataaaa 960
aagagactcc ggacagtgat cttggcacca actagggttg tcgctgctga gatggaggag 1020
gccttgagag gacttccggt gcgttacatg acaacagcag tcaacgtcac ccattctggg 1080
acagaaatcg ttgatttgat gtgccatgcc actttcactt cacgcttact acaacccatc 1140
agagtcccta attacaatct ctacatcatg gatgaagccc acttcacaga cccctcaagt 1200
atagctgcaa gaggatacat atcaacaagg gttgaaatgg gcgaggcggc tgccattttt 1260
atgactgcca caccaccagg aacccgtgat gcgtttcctg actctaactc accaatcatg 1320
gacacagaag tggaagtccc agagagagcc tggagctcag gctttgattg ggtgacagac 1380
cattctggga aaacagtttg gttcgttcca agcgtgagaa acggaaatga aatcgcagcc 1440
tgtctgacaa aggctggaaa gcgggtcata cagctcagca ggaagacttt tgagacagaa 1500
tttcagaaaa caaaaaatca agagtgggac tttgtcataa caactgacat ctcagagatg 1560
ggcgccaact tcaaggctga ccgggtcata gactctagga gatgcctaaa accagtcata 1620
cttgatggtg agagagtcat cttggctggg cccatgcctg tcacgcatgc tagtgctgct 1680
cagaggagag gacgtatagg caggaaccct aacaaacctg gagatgagta catgtatgga 1740
ggtgggtgtg cagagactga tgaaggccat gcacactggc ttgaagcaag aatgcttctt 1800
gacaacatct acctccagga tggcctcata gcctcgctct atcggcctga ggccgataag 1860
gtagccgcca ttgagggaga gtttaagctg aggacagagc aaaggaagac cttcgtggaa 1920
ctcatgaaga gaggagacct tcccgtctgg ctagcctatc aggttgcatc tgccggaata 1980
acttacacag acagaagatg gtgctttgat ggcacaacca acaacaccat aatggaagac 2040
agcgtaccag cagaggtgtg gacaaagtat ggagagaaga gagtgctcaa accgagatgg 2100
atggatgcta gggtctgttc agaccatgcg gccctgaagt cgttcaaaga attcgccgct 2160
ggaaaaagag gagcggcttt gggagtaatg gaggccctgg gaacactgcc aggacacatg 2220
acagagaggt ttcaggaagc cattgacaac ctcgccgtgc tcatgcgagc agagactgga 2280
agcaggcctt ataaggcagc ggcagcccaa ctgccggaga ccctagagac cattatgctc 2340
ttaggtttgc tgggaacagt ttcactgggg atcttcttcg tcttgatgcg gaataagggc 2400
atcgggaaga tgggctttgg aatggtaacc cttggggcca gtgcatggct catgtggctt 2460
tcggaaattg aaccagccag aattgcatgt gtcctcattg ttgtgttttt attactggtg 2520
gtgctcatac ccgagccaga gaagcaaaga tctccccaag ataaccagat ggcaattatc 2580
atcatggtgg cagtgggcct tctaggtttg ataactgcaa acgaacttgg atggctggaa 2640
agaacaaaaa atgacatagc tcatctaatg ggaaggagag aagaaggagc aaccatggga 2700
ttctcaatgg acattgatct gcggccagcc tccgcctggg ctatctatgc cgcattgaca 2760
actctcatca ccccagctgt ccaacatgcg gtaaccactt catacaacaa ctactcctta 2820
atggcgatgg ccacacaagc tggagtgctg tttggcatgg gcaaagggat gccattttat 2880
gcatgggacc ttggagtccc gctgctaatg atgggttgct attcacaatt aacacccctg 2940
actctgatag tagctatcat tctgcttgtg gcgcactaca tgtacttgat cccaggccta 3000
caagcggcag cagcgcgtgc tgcccagaaa aggacagcag ctggcatcat gaagaatccc 3060
gttgtggatg gaatagtggt aactgacatt gacacaatga caatagaccc ccaggtggag 3120
aagaagatgg gacaagtgtt actcatagca gtagccatct ccagtgctgt gctgctgcgg 3180
accgcctggg gatgggggga ggctggagct ctgatcacag cagcgacctc caccttgtgg 3240
gaaggctctc caaacaaata ctggaactcc tctacagcca cctcactgtg caacatcttc 3300
agaggaagct atctggcagg agcttccctt atctatacag tgacgagaaa cgctggcctg 3360
gttaagagac gtggaggtgg gacgggagag actctgggag agaagtggaa agctcgtctg 3420
aatcagatgt cggccctgga gttctactct tataaaaagt caggtatcac tgaagtgtgt 3480
agagaggagg ctcgccgtgc cctcaaggat ggagtggcca caggaggaca tgccgtatcc 3540
cggggaagtg caaagctcag atggttggtg gagagaggat atctgcagcc ctatgggaag 3600
gttgttgacc tcggatgtgg cagagggggc tggagctatt atgccgccac catccgcaaa 3660
gtgcaggagg tgagaggata cacaaaggga ggtcccggtc atgaagaacc catgctggtg 3720
caaagctatg ggtggaacat agttcgtctc aagagtggag tggacgtctt ccacatggcg 3780
gctgagccgt gtgacactct gctgtgtgac ataggtgagt catcatctag tcctgaagtg 3840
gaagagacac gaacactcag agtgctctct atggtggggg actggcttga aaaaagacca 3900
ggggccttct gtataaaggt gctgtgccca tacaccagca ctatgatgga aaccatggag 3960
cgactgcaac gtaggcatgg gggaggatta gtcagagtgc cattgtctcg caactccaca 4020
catgagatgt actgggtctc tggggcaaag agcaacatca taaaaagtgt gtccaccaca 4080
agtcagctcc tcctgggacg catggatggc cccaggaggc cagtgaaata tgaggaggat 4140
gtgaacctcg gctcgggtac acgagctgtg gcaagctgtg ctgaggctcc taacatgaaa 4200
atcatcggca ggcgcattga gagaatccgc aatgaacatg cagaaacatg gtttcttgat 4260
gaaaaccacc catacaggac atgggcctac catgggagct acgaagcccc cacgcaagga 4320
tcagcgtctt ccctcgtgaa cggggttgtt agactcctgt caaagccttg ggacgtggtg 4380
actggagtta caggaatagc catgactgac accacaccat acggccaaca aagagtcttc 4440
aaagaaaaag tggacaccag ggtgccagat ccccaagaag gcactcgcca ggtaatgaac 4500
atagtctctt cctggctgtg gaaggagctg gggaaacgca agcggccacg cgtctgcacc 4560
aaagaagagt ttatcaacaa ggtgcgcagc aatgcagcac tgggagcaat atttgaagag 4620
gaaaaagaat ggaagacggc tgtggaagct gtgaatgatc caaggttttg ggccctagtg 4680
gatagggaga gagaacacca cctgagagga gagtgtcaca gctgtgtgta caacatgatg 4740
ggaaaaagag aaaagaagca aggagagttc gggaaagcaa aaggtagccg cgccatctgg 4800
tacatgtggt tgggagccag attcttggag tttgaagccc ttggattctt gaacgaggac 4860
cattggatgg gaagagaaaa ctcaggaggt ggagtcgaag ggttaggatt gcaaagactt 4920
ggatacattc tagaagaaat gaatcgggca ccaggaggaa agatgtacgc agatgacact 4980
gctggctggg acacccgcat tagtaagttt gatctggaga atgaagctct gattaccaac 5040
caaatggagg aagggcacag aactctggcg ttggccgtga ttaaatacac ataccaaaac 5100
aaagtggtga aggttctcag accagctgaa ggaggaaaaa cagttatgga catcatttca 5160
agacaagacc agagagggag tggacaagtt gtcacttatg ctctcaacac attcaccaac 5220
ttggtggtgc agcttatccg gaacatggaa gctgaggaag tgttagagat gcaagactta 5280
tggttgttga ggaagccaga gaaagtgacc agatggttgc agagcaatgg atgggataga 5340
ctcaaacgaa tggcggtcag tggagatgac tgcgttgtga agccaatcga tgataggttt 5400
gcacatgccc tcaggttctt gaatgacatg ggaaaagtta ggaaagacac acaggagtgg 5460
aaaccctcga ctggatggag caattgggaa gaagtcccgt tctgctccca ccacttcaac 5520
aagctgtacc tcaaggatgg gagatccatt gtggtccctt gccgccacca agatgaactg 5580
attggccgag ctcgcgtctc accaggggca ggatggagca tccgggagac tgcctgtctt 5640
gcaaaatcat atgcgcagat gtggcagctc ctttatttcc acagaagaga ccttcgactg 5700
atggctaatg ccatttgctc ggctgtgcca gttgactggg taccaactgg gagaaccacc 5760
tggtcaatcc atggaaaggg agaatggatg accactgagg acatgctcat ggtgtggaat 5820
agagtgtgga ttgaggagaa cgaccatatg gaggacaaga ctcctgtaac aaaatggaca 5880
gacattccct atctaggaaa aagggaggac ttatggtgtg gatcccttat agggcacaga 5940
ccccgcacca cttgggctga aaacatcaaa gacacagtca acatggtgcg caggatcata 6000
ggtgatgaag aaaagtacat ggactatcta tccacccaag tccgctactt gggtgaggaa 6060
gggtccacac ccggagtgtt gtaagcacca attttagtgt tgtcaggcct gctagtcagc 6120
cacagtttgg ggaaagctgt gcagcctgta acccccccag gagaagctgg gaaaccaagc 6180
tcatagtcag gccgagaacg ccatggcacg gaagaagcca tgctgcctgt gagcccctca 6240
gaggacactg agtcaaaaaa ccccacgcgc ttggaagcgc aggatgggaa aagaaggtgg 6300
cgaccttccc cacccttcaa tctggggcct gaactggaga ctagctgtga atctccagca 6360
gagggactag tggttagagg agaccccccg gaaaacgcaa aacagcatat tgacgctggg 6420
aaagaccaga gactccatga gtttccacca cgctggccgc caggcacaga tcgccgaact 6480
tcggcggccg gtgtggggaa atccatggtt tct 6513
<210> 29
<211> 8136
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 29
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta acaccagaga gggttacaga 600
acccaagtga aagggccatg gcacagtgaa gagcttgaaa tccggtttga ggaatgtcca 660
ggcaccaagg tttacgtgga ggagacatgc ggaactagag gaccatctct gagatcaact 720
actgcaagtg gaagggtcat tgaggaatgg tgctgtaggg aatgcacaat gcccccacta 780
tcgtttcgag caaaagacgg ctgctggtat ggaatggaga taaggcccag gaaagaacca 840
gagagcaact tagtgaggtc aatggtgaca gcggggtcaa ccgatcatat ggaccacttc 900
tctcttggag tgcttgtgat tctactcatg gtgcaggagg ggttgaagaa gagaatgacc 960
acaaagatca tcatgagcac atcaatggca gtgctggtag tcatgatctt gggaggattt 1020
tcaatgagtg acctggccaa gcttgtgatc ctgatgggtg ctactttcgc agaaatgaac 1080
actggaggag atgtagctca cttggcattg gtagcggcat ttaaagtcag accagccttg 1140
ctggtctcct tcattttcag agccaattgg acaccccgtg agagcatgct gctagccctg 1200
gcttcgtgtc ttctgcaaac tgcgatctct gctcttgaag gtgacttgat ggtcctcatt 1260
aatggatttg ctttggcctg gttggcaatt cgagcaatgg ccgtgccacg cactgacaac 1320
atcgctctac caatcttggc tgctctaaca ccactagctc gaggcacact gctcgtggca 1380
tggagagcgg gcctggctac ttgtggaggg atcatgctcc tctccctgaa agggaaaggt 1440
agtgtgaaga agaacctgcc atttgtcatg gccctgggat tgacagctgt gagggtagta 1500
gaccctatta atgtggtagg actactgtta ctcacaagga gtgggaagcg gagctggccc 1560
cctagtgaag ttctcacagc cgttggcctg atatgtgcac tggccggagg gtttgccaag 1620
gcagacattg agatggctgg acccatggct gcagtaggct tgctaattgt cagctatgtg 1680
gtctcgggaa agagtgtgga catgtacatt gaaagagcag gtgacatcac atgggaaaag 1740
gacgcggaag tcactggaaa cagtcctcgg cttgacgtgg cactggatga gagtggtgat 1800
ttctccttgg tagaggaaga tggtccaccc atgagagaga tcatactcaa ggtggtcctg 1860
atggccatct gtggcatgaa cccaatagct ataccttttg ctgcaggagc gtggtatgtg 1920
tatgtgaaga ctgggaaaag gagtggcgcc ctctgggacg tgcctgctcc caaagaagtg 1980
aagaaaggag agaccacaga tggagtgtac agagtgatga ctcgcagact gctaggttca 2040
acacaggttg gagtgggagt catgcaagag ggagtcttcc acaccatgtg gcacgttaca 2100
aaaggagccg cactgaggag cggtgaggga agacttgatc catactgggg ggatgtcaag 2160
caggacttgg tgtcatactg tgggccttgg aagttggatg cagcttggga tggactcagc 2220
gaggtacagc ttttggccgt acctcccgga gagagggcca gaaacattca gaccctgcct 2280
ggaatattca agacaaagga cggggacatc ggagcagttg ctctggacta ccctgcaggg 2340
acctcaggat ctccgatcct agacaaatgt ggaagagtga taggactcta tggcaatggg 2400
gttgtgatca agaatggaag ctatgttagt gctataaccc agggaaagag ggaggaggag 2460
actccggttg aatgtttcga accctcgatg ctgaagaaga agcagctaac tgtcttggat 2520
ctgcatccag gagccggaaa aaccaggaga gttcttcctg aaatagtccg tgaagccata 2580
aaaaagagac tccggacagt gatcttggca ccaactaggg ttgtcgctgc tgagatggag 2640
gaggccttga gaggacttcc ggtgcgttac atgacaacag cagtcaacgt cacccattct 2700
gggacagaaa tcgttgattt gatgtgccat gccactttca cttcacgctt actacaaccc 2760
atcagagtcc ctaattacaa tctctacatc atggatgaag cccacttcac agacccctca 2820
agtatagctg caagaggata catatcaaca agggttgaaa tgggcgaggc ggctgccatt 2880
tttatgactg ccacaccacc aggaacccgt gatgcgtttc ctgactctaa ctcaccaatc 2940
atggacacag aagtggaagt cccagagaga gcctggagct caggctttga ttgggtgaca 3000
gaccattctg ggaaaacagt ttggttcgtt ccaagcgtga gaaacggaaa tgaaatcgca 3060
gcctgtctga caaaggctgg aaagcgggtc atacagctca gcaggaagac ttttgagaca 3120
gaatttcaga aaacaaaaaa tcaagagtgg gactttgtca taacaactga catctcagag 3180
atgggcgcca acttcaaggc tgaccgggtc atagactcta ggagatgcct aaaaccagtc 3240
atacttgatg gtgagagagt catcttggct gggcccatgc ctgtcacgca tgctagtgct 3300
gctcagagga gaggacgtat aggcaggaac cctaacaaac ctggagatga gtacatgtat 3360
ggaggtgggt gtgcagagac tgatgaaggc catgcacact ggcttgaagc aagaatgctt 3420
cttgacaaca tctacctcca ggatggcctc atagcctcgc tctatcggcc tgaggccgat 3480
aaggtagccg ccattgaggg agagtttaag ctgaggacag agcaaaggaa gaccttcgtg 3540
gaactcatga agagaggaga ccttcccgtc tggctagcct atcaggttgc atctgccgga 3600
ataacttaca cagacagaag atggtgcttt gatggcacaa ccaacaacac cataatggaa 3660
gacagcgtac cagcagaggt gtggacaaag tatggagaga agagagtgct caaaccgaga 3720
tggatggatg ctagggtctg ttcagaccat gcggccctga agtcgttcaa agaattcgcc 3780
gctggaaaaa gaggagcggc tttgggagta atggaggccc tgggaacact gccaggacac 3840
atgacagaga ggtttcagga agccattgac aacctcgccg tgctcatgcg agcagagact 3900
ggaagcaggc cttataaggc agcggcagcc caactgccgg agaccctaga gaccattatg 3960
ctcttaggtt tgctgggaac agtttcactg gggatcttct tcgtcttgat gcggaataag 4020
ggcatcggga agatgggctt tggaatggta acccttgggg ccagtgcatg gctcatgtgg 4080
ctttcggaaa ttgaaccagc cagaattgca tgtgtcctca ttgttgtgtt tttattactg 4140
gtggtgctca tacccgagcc agagaagcaa agatctcccc aagataacca gatggcaatt 4200
atcatcatgg tggcagtggg ccttctaggt ttgataactg caaacgaact tggatggctg 4260
gaaagaacaa aaaatgacat agctcatcta atgggaagga gagaagaagg agcaaccatg 4320
ggattctcaa tggacattga tctgcggcca gcctccgcct gggctatcta tgccgcattg 4380
acaactctca tcaccccagc tgtccaacat gcggtaacca cttcatacaa caactactcc 4440
ttaatggcga tggccacaca agctggagtg ctgtttggca tgggcaaagg gatgccattt 4500
tatgcatggg accttggagt cccgctgcta atgatgggtt gctattcaca attaacaccc 4560
ctgactctga tagtagctat cattctgctt gtggcgcact acatgtactt gatcccaggc 4620
ctacaagcgg cagcagcgcg tgctgcccag aaaaggacag cagctggcat catgaagaat 4680
cccgttgtgg atggaatagt ggtaactgac attgacacaa tgacaataga cccccaggtg 4740
gagaagaaga tgggacaagt gttactcata gcagtagcca tctccagtgc tgtgctgctg 4800
cggaccgcct ggggatgggg ggaggctgga gctctgatca cagcagcgac ctccaccttg 4860
tgggaaggct ctccaaacaa atactggaac tcctctacag ccacctcact gtgcaacatc 4920
ttcagaggaa gctatctggc aggagcttcc cttatctata cagtgacgag aaacgctggc 4980
ctggttaaga gacgtggagg tgggacggga gagactctgg gagagaagtg gaaagctcgt 5040
ctgaatcaga tgtcggccct ggagttctac tcttataaaa agtcaggtat cactgaagtg 5100
tgtagagagg aggctcgccg tgccctcaag gatggagtgg ccacaggagg acatgccgta 5160
tcccggggaa gtgcaaagct cagatggttg gtggagagag gatatctgca gccctatggg 5220
aaggttgttg acctcggatg tggcagaggg ggctggagct attatgccgc caccatccgc 5280
aaagtgcagg aggtgagagg atacacaaag ggaggtcccg gtcatgaaga acccatgctg 5340
gtgcaaagct atgggtggaa catagttcgt ctcaagagtg gagtggacgt cttccacatg 5400
gcggctgagc cgtgtgacac tctgctgtgt gacataggtg agtcatcatc tagtcctgaa 5460
gtggaagaga cacgaacact cagagtgctc tctatggtgg gggactggct tgaaaaaaga 5520
ccaggggcct tctgtataaa ggtgctgtgc ccatacacca gcactatgat ggaaaccatg 5580
gagcgactgc aacgtaggca tgggggagga ttagtcagag tgccattgtc tcgcaactcc 5640
acacatgaga tgtactgggt ctctggggca aagagcaaca tcataaaaag tgtgtccacc 5700
acaagtcagc tcctcctggg acgcatggat ggccccagga ggccagtgaa atatgaggag 5760
gatgtgaacc tcggctcggg tacacgagct gtggcaagct gtgctgaggc tcctaacatg 5820
aaaatcatcg gcaggcgcat tgagagaatc cgcaatgaac atgcagaaac atggtttctt 5880
gatgaaaacc acccatacag gacatgggcc taccatggga gctacgaagc ccccacgcaa 5940
ggatcagcgt cttccctcgt gaacggggtt gttagactcc tgtcaaagcc ttgggacgtg 6000
gtgactggag ttacaggaat agccatgact gacaccacac catacggcca acaaagagtc 6060
ttcaaagaaa aagtggacac cagggtgcca gatccccaag aaggcactcg ccaggtaatg 6120
aacatagtct cttcctggct gtggaaggag ctggggaaac gcaagcggcc acgcgtctgc 6180
accaaagaag agtttatcaa caaggtgcgc agcaatgcag cactgggagc aatatttgaa 6240
gaggaaaaag aatggaagac ggctgtggaa gctgtgaatg atccaaggtt ttgggcccta 6300
gtggataggg agagagaaca ccacctgaga ggagagtgtc acagctgtgt gtacaacatg 6360
atgggaaaaa gagaaaagaa gcaaggagag ttcgggaaag caaaaggtag ccgcgccatc 6420
tggtacatgt ggttgggagc cagattcttg gagtttgaag cccttggatt cttgaacgag 6480
gaccattgga tgggaagaga aaactcagga ggtggagtcg aagggttagg attgcaaaga 6540
cttggataca ttctagaaga aatgaatcgg gcaccaggag gaaagatgta cgcagatgac 6600
actgctggct gggacacccg cattagtaag tttgatctgg agaatgaagc tctgattacc 6660
aaccaaatgg aggaagggca cagaactctg gcgttggccg tgattaaata cacataccaa 6720
aacaaagtgg tgaaggttct cagaccagct gaaggaggaa aaacagttat ggacatcatt 6780
tcaagacaag accagagagg gagtggacaa gttgtcactt atgctctcaa cacattcacc 6840
aacttggtgg tgcagcttat ccggaacatg gaagctgagg aagtgttaga gatgcaagac 6900
ttatggttgt tgaggaagcc agagaaagtg accagatggt tgcagagcaa tggatgggat 6960
agactcaaac gaatggcggt cagtggagat gactgcgttg tgaagccaat cgatgatagg 7020
tttgcacatg ccctcaggtt cttgaatgac atgggaaaag ttaggaaaga cacacaggag 7080
tggaaaccct cgactggatg gagcaattgg gaagaagtcc cgttctgctc ccaccacttc 7140
aacaagctgt acctcaagga tgggagatcc attgtggtcc cttgccgcca ccaagatgaa 7200
ctgattggcc gagctcgcgt ctcaccaggg gcaggatgga gcatccggga gactgcctgt 7260
cttgcaaaat catatgcgca gatgtggcag ctcctttatt tccacagaag agaccttcga 7320
ctgatggcta atgccatttg ctcggctgtg ccagttgact gggtaccaac tgggagaacc 7380
acctggtcaa tccatggaaa gggagaatgg atgaccactg aggacatgct catggtgtgg 7440
aatagagtgt ggattgagga gaacgaccat atggaggaca agactcctgt aacaaaatgg 7500
acagacattc cctatctagg aaaaagggag gacttatggt gtggatccct tatagggcac 7560
agaccccgca ccacttgggc tgaaaacatc aaagacacag tcaacatggt gcgcaggatc 7620
ataggtgatg aagaaaagta catggactat ctatccaccc aagtccgcta cttgggtgag 7680
gaagggtcca cacccggagt gttgtaagca ccaattttag tgttgtcagg cctgctagtc 7740
agccacagtt tggggaaagc tgtgcagcct gtaacccccc caggagaagc tgggaaacca 7800
agctcatagt caggccgaga acgccatggc acggaagaag ccatgctgcc tgtgagcccc 7860
tcagaggaca ctgagtcaaa aaaccccacg cgcttggaag cgcaggatgg gaaaagaagg 7920
tggcgacctt ccccaccctt caatctgggg cctgaactgg agactagctg tgaatctcca 7980
gcagagggac tagtggttag aggagacccc ccggaaaacg caaaacagca tattgacgct 8040
gggaaagacc agagactcca tgagtttcca ccacgctggc cgccaggcac agatcgccga 8100
acttcggcgg ccggtgtggg gaaatccatg gtttct 8136
<210> 30
<211> 10224
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 30
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1080
acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga 1140
ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1200
aacacaaggt gaggcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1260
attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1320
atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1380
ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttgtcaatga 1440
tacaggatat gaaactgacg aaaatagagc gaaagtcgag gttacgccta attcaccaag 1500
agcggaagca accttgggag gctttggaag cttaggactt gactgtgaac caaggacagg 1560
ccttgacttt tcagatctgt attacctgac catgaacaat aagcattggt tggtgcacaa 1620
agagtggttt catgacatcc cattgccttg gcatgctggg gcagacaccg gaactccaca 1680
ctggaacaac aaagaggcat tggtagaatt caaggatgcc cacgccaaga ggcaaaccgt 1740
cgtcgttctg gggagccagg aaggagccgt tcacacggct ctcgctggag ctctagaggc 1800
tgagatggat ggtgcaaagg gaaagctgtt ctctggccac ttgaaatgcc gcctaaaaat 1860
ggacaagctt agattgaagg gcgtgtcata ttccttgtgc actgcggcat tcacattcac 1920
caaggtccca gctgaaacac tgcatggaac agtcacagtg gaggtgcagt atgcagggac 1980
agatggaccc tgcaagatcc cagtccagat ggcggtggac atgcagaccc tgaccccagt 2040
tggaaggctg ataaccgcca accccgtgat tactgaaagc actgagaact caaagatgat 2100
gttggagctt gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa 2160
aatcacccac cactggcata ggagtggtag caccatcgga aaggcatttg aggccactgt 2220
gagaggcgcc aagagaatgg cagtcctggg ggatacagcc tgggacttcg gatcagtcgg 2280
gggtgtgttc aactcactgg gtaagggcat tcaccagatt tttggagcag ccttcaaatc 2340
actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tagtgtggtt 2400
aggtttgaac acaaagaatg gatctatctc cctcacatgc ttggccctgg ggggagtgat 2460
gatcttcctc tccacggctg tttctgctga tgtggggtgc tcagtggact tctcaaaaaa 2520
ggaaacgaga tgtggcacgg gggtattcat ctataatgat gttgaagcct ggagggaccg 2580
gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcctggga 2640
agaggggatc tgtgggatct catccgtttc aagaatggaa aacatcatgt ggaaatcagt 2700
agaaggggag ctcaatgcta tcctagagga gaatggagtt caactgacag ttgttgtggg 2760
atctgtaaaa aaccccatgt ggagaggtcc acaaagattg ccagtgcctg tgaatgagct 2820
gccccatggc tggaaagcct gggggaaatc gtattttgtt agggcggcaa agaccaacaa 2880
cagttttgtt gtcgacggtg acacactgaa ggaatgtccg cttgagcaca gagcatggaa 2940
tagttttctt gtggaggatc acgggtttgg agtcttccac accagtgtct ggcttaaggt 3000
cagagaagat tactcattag aatgtgaccc agccgtcata ggaacagctg ttaagggaag 3060
ggaggccgcg cacagtgatc tgggctattg gattgaaagt gaaaagaatg acacatggag 3120
gctgaagagg gcccacctga ttgagatgaa aacatgtgaa tggccaaagt ctcacacatt 3180
gtggacagat ggagtagaag aaagtgatct tatcataccc aagtctttag ctggtccact 3240
cagccaccac aacaccagag agggttacag aacccaagtg aaagggccat ggcacagtga 3300
agagcttgaa atccggtttg aggaatgtcc aggcaccaag gtttacgtgg aggagacatg 3360
cggaactaga ggaccatctc tgagatcaac tactgcaagt ggaagggtca ttgaggaatg 3420
gtgctgtagg gaatgcacaa tgcccccact atcgtttcga gcaaaagacg gctgctggta 3480
tggaatggag ataaggccca ggaaagaacc agagagcaac ttagtgaggt caatggtgac 3540
agcggggtca accgatcata tggaccactt ctctcttgga gtgcttgtga ttctactcat 3600
ggtgcaggag gggttgaaga agagaatgac cacaaagatc atcatgagca catcaatggc 3660
agtgctggta gtcatgatct tgggaggatt ttcaatgagt gacctggcca agcttgtgat 3720
cctgatgggt gctactttcg cagaaatgaa cactggagga gatgtagctc acttggcatt 3780
ggtagcggca tttaaagtca gaccagcctt gctggtctcc ttcattttca gagccaattg 3840
gacaccccgt gagagcatgc tgctagccct ggcttcgtgt cttctgcaaa ctgcgatctc 3900
tgctcttgaa ggtgacttga tggtcctcat taatggattt gctttggcct ggttggcaat 3960
tcgagcaatg gccgtgccac gcactgacaa catcgctcta ccaatcttgg ctgctctaac 4020
accactagct cgaggcacac tgctcgtggc atggagagcg ggcctggcta cttgtggagg 4080
gatcatgctc ctctccctga aagggaaagg tagtgtgaag aagaacctgc catttgtcat 4140
ggccctggga ttgacagctg tgagggtagt agaccctatt aatgtggtag gactactgtt 4200
actcacaagg agtgggaagc ggagctggcc ccctagtgaa gttctcacag ccgttggcct 4260
gatatgtgca ctggccggag ggtttgccaa ggcagacatt gagatggctg gacccatggc 4320
tgcagtaggc ttgctaattg tcagctatgt ggtctcggga aagagtgtgg acatgtacat 4380
tgaaagagca ggtgacatca catgggaaaa ggacgcggaa gtcactggaa acagtcctcg 4440
gcttgacgtg gcactggatg agagtggtga tttctccttg gtagaggaag atggtccacc 4500
catgagagag atcatactca aggtggtcct gatggccatc tgtggcatga acccaatagc 4560
tatacctttt gctgcaggag cgtggtatgt gtatgtgaag actgggaaaa ggagtggcgc 4620
cctctgggac gtgcctgctc ccaaagaagt gaagaaagga gagaccacag atggagtgta 4680
cagagtgatg actcgcagac tgctaggttc aacacaggtt ggagtgggag tcatgcaaga 4740
gggagtcttc cacaccatgt ggcacgttac aaaaggagcc gcactgagga gcggtgaggg 4800
aagacttgat ccatactggg gggatgtcaa gcaggacttg gtgtcatact gtgggccttg 4860
gaagttggat gcagcttggg atggactcag cgaggtacag cttttggccg tacctcccgg 4920
agagagggcc agaaacattc agaccctgcc tggaatattc aagacaaagg acggggacat 4980
cggagcagtt gctctggact accctgcagg gacctcagga tctccgatcc tagacaaatg 5040
tggaagagtg ataggactct atggcaatgg ggttgtgatc aagaatggaa gctatgttag 5100
tgctataacc cagggaaaga gggaggagga gactccggtt gaatgtttcg aaccctcgat 5160
gctgaagaag aagcagctaa ctgtcttgga tctgcatcca ggagccggaa aaaccaggag 5220
agttcttcct gaaatagtcc gtgaagccat aaaaaagaga ctccggacag tgatcttggc 5280
accaactagg gttgtcgctg ctgagatgga ggaggccttg agaggacttc cggtgcgtta 5340
catgacaaca gcagtcaacg tcacccattc tgggacagaa atcgttgatt tgatgtgcca 5400
tgccactttc acttcacgct tactacaacc catcagagtc cctaattaca atctctacat 5460
catggatgaa gcccacttca cagacccctc aagtatagct gcaagaggat acatatcaac 5520
aagggttgaa atgggcgagg cggctgccat ttttatgact gccacaccac caggaacccg 5580
tgatgcgttt cctgactcta actcaccaat catggacaca gaagtggaag tcccagagag 5640
agcctggagc tcaggctttg attgggtgac agaccattct gggaaaacag tttggttcgt 5700
tccaagcgtg agaaacggaa atgaaatcgc agcctgtctg acaaaggctg gaaagcgggt 5760
catacagctc agcaggaaga cttttgagac agaatttcag aaaacaaaaa atcaagagtg 5820
ggactttgtc ataacaactg acatctcaga gatgggcgcc aacttcaagg ctgaccgggt 5880
catagactct aggagatgcc taaaaccagt catacttgat ggtgagagag tcatcttggc 5940
tgggcccatg cctgtcacgc atgctagtgc tgctcagagg agaggacgta taggcaggaa 6000
ccctaacaaa cctggagatg agtacatgta tggaggtggg tgtgcagaga ctgatgaagg 6060
ccatgcacac tggcttgaag caagaatgct tcttgacaac atctacctcc aggatggcct 6120
catagcctcg ctctatcggc ctgaggccga taaggtagcc gccattgagg gagagtttaa 6180
gctgaggaca gagcaaagga agaccttcgt ggaactcatg aagagaggag accttcccgt 6240
ctggctagcc tatcaggttg catctgccgg aataacttac acagacagaa gatggtgctt 6300
tgatggcaca accaacaaca ccataatgga agacagcgta ccagcagagg tgtggacaaa 6360
gtatggagag aagagagtgc tcaaaccgag atggatggat gctagggtct gttcagacca 6420
tgcggccctg aagtcgttca aagaattcgc cgctggaaaa agaggagcgg ctttgggagt 6480
aatggaggcc ctgggaacac tgccaggaca catgacagag aggtttcagg aagccattga 6540
caacctcgcc gtgctcatgc gagcagagac tggaagcagg ccttataagg cagcggcagc 6600
ccaactgccg gagaccctag agaccattat gctcttaggt ttgctgggaa cagtttcact 6660
ggggatcttc ttcgtcttga tgcggaataa gggcatcggg aagatgggct ttggaatggt 6720
aacccttggg gccagtgcat ggctcatgtg gctttcggaa attgaaccag ccagaattgc 6780
atgtgtcctc attgttgtgt ttttattact ggtggtgctc atacccgagc cagagaagca 6840
aagatctccc caagataacc agatggcaat tatcatcatg gtggcagtgg gccttctagg 6900
tttgataact gcaaacgaac ttggatggct ggaaagaaca aaaaatgaca tagctcatct 6960
aatgggaagg agagaagaag gagcaaccat gggattctca atggacattg atctgcggcc 7020
agcctccgcc tgggctatct atgccgcatt gacaactctc atcaccccag ctgtccaaca 7080
tgcggtaacc acttcataca acaactactc cttaatggcg atggccacac aagctggagt 7140
gctgtttggc atgggcaaag ggatgccatt ttatgcatgg gaccttggag tcccgctgct 7200
aatgatgggt tgctattcac aattaacacc cctgactctg atagtagcta tcattctgct 7260
tgtggcgcac tacatgtact tgatcccagg cctacaagcg gcagcagcgc gtgctgccca 7320
gaaaaggaca gcagctggca tcatgaagaa tcccgttgtg gatggaatag tggtaactga 7380
cattgacaca atgacaatag acccccaggt ggagaagaag atgggacaag tgttactcat 7440
agcagtagcc atctccagtg ctgtgctgct gcggaccgcc tggggatggg gggaggctgg 7500
agctctgatc acagcagcga cctccacctt gtgggaaggc tctccaaaca aatactggaa 7560
ctcctctaca gccacctcac tgtgcaacat cttcagagga agctatctgg caggagcttc 7620
ccttatctat acagtgacga gaaacgctgg cctggttaag agacgtggag gtgggacggg 7680
agagactctg ggagagaagt ggaaagctcg tctgaatcag atgtcggccc tggagttcta 7740
ctcttataaa aagtcaggta tcactgaagt gtgtagagag gaggctcgcc gtgccctcaa 7800
ggatggagtg gccacaggag gacatgccgt atcccgggga agtgcaaagc tcagatggtt 7860
ggtggagaga ggatatctgc agccctatgg gaaggttgtt gacctcggat gtggcagagg 7920
gggctggagc tattatgccg ccaccatccg caaagtgcag gaggtgagag gatacacaaa 7980
gggaggtccc ggtcatgaag aacccatgct ggtgcaaagc tatgggtgga acatagttcg 8040
tctcaagagt ggagtggacg tcttccacat ggcggctgag ccgtgtgaca ctctgctgtg 8100
tgacataggt gagtcatcat ctagtcctga agtggaagag acacgaacac tcagagtgct 8160
ctctatggtg ggggactggc ttgaaaaaag accaggggcc ttctgtataa aggtgctgtg 8220
cccatacacc agcactatga tggaaaccat ggagcgactg caacgtaggc atgggggagg 8280
attagtcaga gtgccattgt ctcgcaactc cacacatgag atgtactggg tctctggggc 8340
aaagagcaac atcataaaaa gtgtgtccac cacaagtcag ctcctcctgg gacgcatgga 8400
tggccccagg aggccagtga aatatgagga ggatgtgtgt acaacatgat gggaaaaaga 8460
gaaaagaagc aaggagagtt cgggaaagca aaaggtagcc gcgccatctg gtacatgtgg 8520
ttgggagcca gattcttgga gtttgaagcc cttggattct tgaacgagga ccattggatg 8580
ggaagagaaa actcaggagg tggagtcgaa gggttaggat tgcaaagact tggatacatt 8640
ctagaagaaa tgaatcgggc accaggagga aagatgtacg cagatgacac tgctggctgg 8700
gacacccgca ttagtaagtt tgatctggag aatgaagctc tgattaccaa ccaaatggag 8760
gaagggcaca gaactctggc gttggccgtg attaaataca cataccaaaa caaagtggtg 8820
aaggttctca gaccagctga aggaggaaaa acagttatgg acatcatttc aagacaagac 8880
cagagaggga gtggacaagt tgtcacttat gctctcaaca cattcaccaa cttggtggtg 8940
cagcttatcc ggaacatgga agctgaggaa gtgttagaga tgcaagactt atggttgttg 9000
aggaagccag agaaagtgac cagatggttg cagagcaatg gatgggatag actcaaacga 9060
atggcggtca gtggagatga ctgcgttgtg aagccaatcg atgataggtt tgcacatgcc 9120
ctcaggttct tgaatgacat gggaaaagtt aggaaagaca cacaggagtg gaaaccctcg 9180
actggatgga gcaattggga agaagtcccg ttctgctccc accacttcaa caagctgtac 9240
ctcaaggatg ggagatccat tgtggtccct tgccgccacc aagatgaact gattggccga 9300
gctcgcgtct caccaggggc aggatggagc atccgggaga ctgcctgtct tgcaaaatca 9360
tatgcgcaga tgtggcagct cctttatttc cacagaagag accttcgact gatggctaat 9420
gccatttgct cggctgtgcc agttgactgg gtaccaactg ggagaaccac ctggtcaatc 9480
catggaaagg gagaatggat gaccactgag gacatgctca tggtgtggaa tagagtgtgg 9540
attgaggaga acgaccatat ggaggacaag actcctgtaa caaaatggac agacattccc 9600
tatctaggaa aaagggagga cttatggtgt ggatccctta tagggcacag accccgcacc 9660
acttgggctg aaaacatcaa agacacagtc aacatggtgc gcaggatcat aggtgatgaa 9720
gaaaagtaca tggactatct atccacccaa gtccgctact tgggtgagga agggtccaca 9780
cccggagtgt tgtaagcacc aattttagtg ttgtcaggcc tgctagtcag ccacagtttg 9840
gggaaagctg tgcagcctgt aaccccccca ggagaagctg ggaaaccaag ctcatagtca 9900
ggccgagaac gccatggcac ggaagaagcc atgctgcctg tgagcccctc agaggacact 9960
gagtcaaaaa accccacgcg cttggaagcg caggatggga aaagaaggtg gcgaccttcc 10020
ccacccttca atctggggcc tgaactggag actagctgtg aatctccagc agagggacta 10080
gtggttagag gagacccccc ggaaaacgca aaacagcata ttgacgctgg gaaagaccag 10140
agactccatg agtttccacc acgctggccg ccaggcacag atcgccgaac ttcggcggcc 10200
ggtgtgggga aatccatggt ttct 10224
<210> 31
<211> 10272
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 31
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1080
acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga 1140
ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1200
aacacaaggt gaggcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1260
attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1320
atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1380
ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttgtcaatga 1440
tacaggatat gaaactgacg aaaatagagc gaaagtcgag gttacgccta attcaccaag 1500
agcggaagca accttgggag gctttggaag cttaggactt gactgtgaac caaggacagg 1560
ccttgacttt tcagatctgt attacctgac catgaacaat aagcattggt tggtgcacaa 1620
agagtggttt catgacatcc cattgccttg gcatgctggg gcagacaccg gaactccaca 1680
ctggaacaac aaagaggcat tggtagaatt caaggatgcc cacgccaaga ggcaaaccgt 1740
cgtcgttctg gggagccagg aaggagccgt tcacacggct ctcgctggag ctctagaggc 1800
tgagatggat ggtgcaaagg gaaagctgtt ctctggccac ttgaaatgcc gcctaaaaat 1860
ggacaagctt agattgaagg gcgtgtcata ttccttgtgc actgcggcat tcacattcac 1920
caaggtccca gctgaaacac tgcatggaac agtcacagtg gaggtgcagt atgcagggac 1980
agatggaccc tgcaagatcc cagtccagat ggcggtggac atgcagaccc tgaccccagt 2040
tggaaggctg ataaccgcca accccgtgat tactgaaagc actgagaact caaagatgat 2100
gttggagctt gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa 2160
aatcacccac cactggcata ggagtggtag caccatcgga aaggcatttg aggccactgt 2220
gagaggcgcc aagagaatgg cagtcctggg ggatacagcc tgggacttcg gatcagtcgg 2280
gggtgtgttc aactcactgg gtaagggcat tcaccagatt tttggagcag ccttcaaatc 2340
actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tagtgtggtt 2400
aggtttgaac acaaagaatg gatctatctc cctcacatgc ttggccctgg ggggagtgat 2460
gatcttcctc tccacggctg tttctgctga tgtggggtgc tcagtggact tctcaaaaaa 2520
ggaaacgaga tgtggcacgg gggtattcat ctataatgat gttgaagcct ggagggaccg 2580
gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcctggga 2640
agaggggatc tgtgggatct catccgtttc aagaatggaa aacatcatgt ggaaatcagt 2700
agaaggggag ctcaatgcta tcctagagga gaatggagtt caactgacag ttgttgtggg 2760
atctgtaaaa aaccccatgt ggagaggtcc acaaagattg ccagtgcctg tgaatgagct 2820
gccccatggc tggaaagcct gggggaaatc gtattttgtt agggcggcaa agaccaacaa 2880
cagttttgtt gtcgacggtg acacactgaa ggaatgtccg cttgagcaca gagcatggaa 2940
tagttttctt gtggaggatc acgggtttgg agtcttccac accagtgtct ggcttaaggt 3000
cagagaagat tactcattag aatgtgaccc agccgtcata ggaacagctg ttaagggaag 3060
ggaggccgcg cacagtgatc tgggctattg gattgaaagt gaaaagaatg acacatggag 3120
gctgaagagg gcccacctga ttgagatgaa aacatgtgaa tggccaaagt ctcacacatt 3180
gtggacagat ggagtagaag aaagtgatct tatcataccc aagtctttag ctggtccact 3240
cagccaccac aacaccagag agggttacag aacccaagtg aaagggccat ggcacagtga 3300
agagcttgaa atccggtttg aggaatgtcc aggcaccaag gtttacgtgg aggagacatg 3360
cggaactaga ggaccatctc tgagatcaac tactgcaagt ggaagggtca ttgaggaatg 3420
gtgctgtagg gaatgcacaa tgcccccact atcgtttcga gcaaaagacg gctgctggta 3480
tggaatggag ataaggccca ggaaagaacc agagagcaac ttagtgaggt caatggtgac 3540
agcggggtca accgatcata tggaccactt ctctcttgga gtgcttgtga ttctactcat 3600
ggtgcaggag gggttgaaga agagaatgac cacaaagatc atcatgagca catcaatggc 3660
agtgctggta gtcatgatct tgggaggatt ttcaatgagt gacctggcca agcttgtgat 3720
cctgatgggt gctactttcg cagaaatgaa cactggagga gatgtagctc acttggcatt 3780
ggtagcggca tttaaagtca gaccagcctt gctggtctcc ttcattttca gagccaattg 3840
gacaccccgt gagagcatgc tgctagccct ggcttcgtgt cttctgcaaa ctgcgatctc 3900
tgctcttgaa ggtgacttga tggtcctcat taatggattt gctttggcct ggttggcaat 3960
tcgagcaatg gccgtgccac gcactgacaa catcgctcta ccaatcttgg ctgctctaac 4020
accactagct cgaggcacac tgctcgtggc atggagagcg ggcctggcta cttgtggagg 4080
gatcatgctc ctctccctga aagggaaagg tagtgtgaag aagaacctgc catttgtcat 4140
ggccctggga ttgacagctg tgagggtagt agaccctatt aatgtggtag gactactgtt 4200
actcacaagg agtgggaagc ggagctggcc ccctagtgaa gttctcacag ccgttggcct 4260
gatatgtgca ctggccggag ggtttgccaa ggcagacatt gagatggctg gacccatggc 4320
tgcagtaggc ttgctaattg tcagctatgt ggtctcggga aagagtgtgg acatgtacat 4380
tgaaagagca ggtgacatca catgggaaaa ggacgcggaa gtcactggaa acagtcctcg 4440
gcttgacgtg gcactggatg agagtggtga tttctccttg gtagaggaag atggtccacc 4500
catgagagag atcatactca aggtggtcct gatggccatc tgtggcatga acccaatagc 4560
tatacctttt gctgcaggag cgtggtatgt gtatgtgaag actgggaaaa ggagtggcgc 4620
cctctgggac gtgcctgctc ccaaagaagt gaagaaagga gagaccacag atggagtgta 4680
cagagtgatg actcgcagac tgctaggttc aacacaggtt ggagtgggag tcatgcaaga 4740
gggagtcttc cacaccatgt ggcacgttac aaaaggagcc gcactgagga gcggtgaggg 4800
aagacttgat ccatactggg gggatgtcaa gcaggacttg gtgtcatact gtgggccttg 4860
gaagttggat gcagcttggg atggactcag cgaggtacag cttttggccg tacctcccgg 4920
agagagggcc agaaacattc agaccctgcc tggaatattc aagacaaagg acggggacat 4980
cggagcagtt gctctggact accctgcagg gacctcagga tctccgatcc tagacaaatg 5040
tggaagagtg ataggactct atggcaatgg ggttgtgatc aagaatggaa gctatgttag 5100
tgctataacc cagggaaaga gggaggagga gactccggtt gaatgtttcg aaccctcgat 5160
gctgaagaag aagcagctaa ctgtcttgga tctgcatcca ggagccggaa aaaccaggag 5220
agttcttcct gaaatagtcc gtgaagccat aaaaaagaga ctccggacag tgatcttggc 5280
accaactagg gttgtcgctg ctgagatgga ggaggccttg agaggacttc cggtgcgtta 5340
catgacaaca gcagtcaacg tcacccattc tgggacagaa atcgttgatt tgatgtgcca 5400
tgccactttc acttcacgct tactacaacc catcagagtc cctaattaca atctctacat 5460
catggatgaa gcccacttca cagacccctc aagtatagct gcaagaggat acatatcaac 5520
aagggttgaa atgggcgagg cggctgccat ttttatgact gccacaccac caggaacccg 5580
tgatgcgttt cctgactcta actcaccaat catggacaca gaagtggaag tcccagagag 5640
agcctggagc tcaggctttg attgggtgac agaccattct gggaaaacag tttggttcgt 5700
tccaagcgtg agaaacggaa atgaaatcgc agcctgtctg acaaaggctg gaaagcgggt 5760
catacagctc agcaggaaga cttttgagac agaatttcag aaaacaaaaa atcaagagtg 5820
ggactttgtc ataacaactg acatctcaaa ccgagatgga tggatgctag ggtctgttca 5880
gaccatgcgg ccctgaagtc gttcaaagaa ttcgccgctg gaaaaagagg agcggctttg 5940
ggagtaatgg aggccctggg aacactgcca ggacacatga cagagaggtt tcaggaagcc 6000
attgacaacc tcgccgtgct catgcgagca gagactggaa gcaggcctta taaggcagcg 6060
gcagcccaac tgccggagac cctagagacc attatgctct taggtttgct gggaacagtt 6120
tcactgggga tcttcttcgt cttgatgcgg aataagggca tcgggaagat gggctttgga 6180
atggtaaccc ttggggccag tgcatggctc atgtggcttt cggaaattga accagccaga 6240
attgcatgtg tcctcattgt tgtgttttta ttactggtgg tgctcatacc cgagccagag 6300
aagcaaagat ctccccaaga taaccagatg gcaattatca tcatggtggc agtgggcctt 6360
ctaggtttga taactgcaaa cgaacttgga tggctggaaa gaacaaaaaa tgacatagct 6420
catctaatgg gaaggagaga agaaggagca accatgggat tctcaatgga cattgatctg 6480
cggccagcct ccgcctgggc tatctatgcc gcattgacaa ctctcatcac cccagctgtc 6540
caacatgcgg taaccacttc atacaacaac tactccttaa tggcgatggc cacacaagct 6600
ggagtgctgt ttggcatggg caaagggatg ccattttatg catgggacct tggagtcccg 6660
ctgctaatga tgggttgcta ttcacaatta acacccctga ctctgatagt agctatcatt 6720
ctgcttgtgg cgcactacat gtacttgatc ccaggcctac aagcggcagc agcgcgtgct 6780
gcccagaaaa ggacagcagc tggcatcatg aagaatcccg ttgtggatgg aatagtggta 6840
actgacattg acacaatgac aatagacccc caggtggaga agaagatggg acaagtgtta 6900
ctcatagcag tagccatctc cagtgctgtg ctgctgcgga ccgcctgggg atggggggag 6960
gctggagctc tgatcacagc agcgacctcc accttgtggg aaggctctcc aaacaaatac 7020
tggaactcct ctacagccac ctcactgtgc aacatcttca gaggaagcta tctggcagga 7080
gcttccctta tctatacagt gacgagaaac gctggcctgg ttaagagacg tggaggtggg 7140
acgggagaga ctctgggaga gaagtggaaa gctcgtctga atcagatgtc ggccctggag 7200
ttctactctt ataaaaagtc aggtatcact gaagtgtgta gagaggaggc tcgccgtgcc 7260
ctcaaggatg gagtggccac aggaggacat gccgtatccc ggggaagtgc aaagctcaga 7320
tggttggtgg agagaggata tctgcagccc tatgggaagg ttgttgacct cggatgtggc 7380
agagggggct ggagctatta tgccgccacc atccgcaaag tgcaggaggt gagaggatac 7440
acaaagggag gtcccggtca tgaagaaccc atgctggtgc aaagctatgg gtggaacata 7500
gttcgtctca agagtggagt ggacgtcttc cacatggcgg ctgagccgtg tgacactctg 7560
ctgtgtgaca taggtgagtc atcatctagt cctgaagtgg aagagacacg aacactcaga 7620
gtgctctcta tggtggggga ctggcttgaa aaaagaccag gggccttctg tataaaggtg 7680
ctgtgcccat acaccagcac tatgatggaa accatggagc gactgcaacg taggcatggg 7740
ggaggattag tcagagtgcc attgtctcgc aactccacac atgagatgta ctgggtctct 7800
ggggcaaaga gcaacatcat aaaaagtgtg tccaccacaa gtcagctcct cctgggacgc 7860
atggatggcc ccaggaggcc agtgaaatat gaggaggatg tgaacctcgg ctcgggtaca 7920
cgagctgtgg caagctgtgc tgaggctcct aacatgaaaa tcatcggcag gcgcattgag 7980
agaatccgca atgaacatgc agaaacatgg tttcttgatg aaaaccaccc atacaggaca 8040
tgggcctacc atgggagcta cgaagccccc acgcaaggat cagcgtcttc cctcgtgaac 8100
ggggttgtta gactcctgtc aaagccttgg gacgtggtga ctggagttac aggaatagcc 8160
atgactgaca ccacaccata cggccaacaa agagtcttca aagaaaaagt ggacaccagg 8220
gtgccagatc cccaagaagg cactcgccag gtaatgaaca tagtctcttc ctggctgtgg 8280
aaggagctgg ggaaacgcaa gcggccacgc gtctgcacca aagaagagtt tatcaacaag 8340
gtgcgcagca atgcagcact gggagcaata tttgaagagg aaaaagaatg gaagacggct 8400
gtggaagctg tgaatgatcc aaggttttgg gccctagtgg atagggagag agaacaccac 8460
ctgagaggag agtgtcacag ctgtgtgtac aacatgatgg gaaaaagaga aaagaagcaa 8520
ggagagttcg ggaaagcaaa aggtagccgc gccatctggt acatgtggtt gggagccaga 8580
ttcttggagt ttgaagccct tggattcttg aacgaggacc attggatggg aagagaaaac 8640
tcaggaggtg gagtcgaagg gttaggattg caaagacttg gatacattct agaagaaatg 8700
aatcgggcac caggaggaaa gatgtacgca gatgacactg ctggctggga cacccgcatt 8760
agtaagtttg atctggagaa tgaagctctg attaccaacc aaatggagga agggcacaga 8820
actctggcgt tggccgtgat taaatacaca taccaaaaca aagtggtgaa ggttctcaga 8880
ccagctgaag gaggaaaaac agttatggac atcatttcaa gacaagacca gagagggagt 8940
ggacaagttg tcacttatgc tctcaacaca ttcaccaact tggtggtgca gcttatccgg 9000
aacatggaag ctgaggaagt gttagagatg caagacttat ggttgttgag gaagccagag 9060
aaagtgacca gatggttgca gagcaatgga tgggatagac tcaaacgaat ggcggtcagt 9120
ggagatgact gcgttgtgaa gccaatcgat gataggtttg cacatgccct caggttcttg 9180
aatgacatgg gaaaagttag gaaagacaca caggagtgga aaccctcgac tggatggagc 9240
aattgggaag aagtcccgtt ctgctcccac cacttcaaca agctgtacct caaggatggg 9300
agatccattg tggtcccttg ccgccaccaa gatgaactga ttggccgagc tcgcgtctca 9360
ccaggggcag gatggagcat ccgggagact gcctgtcttg caaaatcata tgcgcagatg 9420
tggcagctcc tttatttcca cagaagagac cttcgactga tggctaatgc catttgctcg 9480
gctgtgccag ttgactgggt accaactggg agaaccacct ggtcaatcca tggaaaggga 9540
gaatggatga ccactgagga catgctcatg gtgtggaata gagtgtggat tgaggagaac 9600
gaccatatgg aggacaagac tcctgtaaca aaatggacag acattcccta tctaggaaaa 9660
agggaggact tatggtgtgg atcccttata gggcacagac cccgcaccac ttgggctgaa 9720
aacatcaaag acacagtcaa catggtgcgc aggatcatag gtgatgaaga aaagtacatg 9780
gactatctat ccacccaagt ccgctacttg ggtgaggaag ggtccacacc cggagtgttg 9840
taagcaccaa ttttagtgtt gtcaggcctg ctagtcagcc acagtttggg gaaagctgtg 9900
cagcctgtaa cccccccagg agaagctggg aaaccaagct catagtcagg ccgagaacgc 9960
catggcacgg aagaagccat gctgcctgtg agcccctcag aggacactga gtcaaaaaac 10020
cccacgcgct tggaagcgca ggatgggaaa agaaggtggc gaccttcccc acccttcaat 10080
ctggggcctg aactggagac tagctgtgaa tctccagcag agggactagt ggttagagga 10140
gaccccccgg aaaacgcaaa acagcatatt gacgctggga aagaccagag actccatgag 10200
tttccaccac gctggccgcc aggcacagat cgccgaactt cggcggccgg tgtggggaaa 10260
tccatggttt ct 10272
<210> 32
<211> 8137
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 32
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta aacaccagag agggttacag 600
aacccaagtg aaagggccat ggcacagtga agagcttgaa atccggtttg aggaatgtcc 660
aggcaccaag gtttacgtgg aggagacatg cggaactaga ggaccatctc tgagatcaac 720
tactgcaagt ggaagggtca ttgaggaatg gtgctgtagg gaatgcacaa tgcccccact 780
atcgtttcga gcaaaagacg gctgctggta tggaatggag ataaggccca ggaaagaacc 840
agagagcaac ttagtgaggt caatggtgac agcggggtca accgatcata tggaccactt 900
ctctcttgga gtgcttgtga ttctactcat ggtgcaggag gggttgaaga agagaatgac 960
cacaaagatc atcatgagca catcaatggc agtgctggta gtcatgatct tgggaggatt 1020
ttcaatgagt gacctggcca agcttgtgat cctgatgggt gctactttcg cagaaatgaa 1080
cactggagga gatgtagctc acttggcatt ggtagcggca tttaaagtca gaccagcctt 1140
gctggtctcc ttcattttca gagccaattg gacaccccgt gagagcatgc tgctagccct 1200
ggcttcgtgt cttctgcaaa ctgcgatctc tgctcttgaa ggtgacttga tggtcctcat 1260
taatggattt gctttggcct ggttggcaat tcgagcaatg gccgtgccac gcactgacaa 1320
catcgctcta ccaatcttgg ctgctctaac accactagct cgaggcacac tgctcgtggc 1380
atggagagcg ggcctggcta cttgtggagg gatcatgctc ctctccctga aagggaaagg 1440
tagtgtgaag aagaacctgc catttgtcat ggccctggga ttgacagctg tgagggtagt 1500
agaccctatt aatgtggtag gactactgtt actcacaagg agtgggaagc ggagctggcc 1560
ccctagtgaa gttctcacag ccgttggcct gatatgtgca ctggccggag ggtttgccaa 1620
ggcagacatt gagatggctg gacccatggc tgcagtaggc ttgctaattg tcagctatgt 1680
ggtctcggga aagagtgtgg acatgtacat tgaaagagca ggtgacatca catgggaaaa 1740
ggacgcggaa gtcactggaa acagtcctcg gcttgacgtg gcactggatg agagtggtga 1800
tttctccttg gtagaggaag atggtccacc catgagagag atcatactca aggtggtcct 1860
gatggccatc tgtggcatga acccaatagc tatacctttt gctgcaggag cgtggtatgt 1920
gtatgtgaag actgggaaaa ggagtggcgc cctctgggac gtgcctgctc ccaaagaagt 1980
gaagaaagga gagaccacag atggagtgta cagagtgatg actcgcagac tgctaggttc 2040
aacacaggtt ggagtgggag tcatgcaaga gggagtcttc cacaccatgt ggcacgttac 2100
aaaaggagcc gcactgagga gcggtgaggg aagacttgat ccatactggg gggatgtcaa 2160
gcaggacttg gtgtcatact gtgggccttg gaagttggat gcagcttggg atggactcag 2220
cgaggtacag cttttggccg tacctcccgg agagagggcc agaaacattc agaccctgcc 2280
tggaatattc aagacaaagg acggggacat cggagcagtt gctctggact accctgcagg 2340
gacctcagga tctccgatcc tagacaaatg tggaagagtg ataggactct atggcaatgg 2400
ggttgtgatc aagaatggaa gctatgttag tgctataacc cagggaaaga gggaggagga 2460
gactccggtt gaatgtttcg aaccctcgat gctgaagaag aagcagctaa ctgtcttgga 2520
tctgcatcca ggagccggaa aaaccaggag agttcttcct gaaatagtcc gtgaagccat 2580
aaaaaagaga ctccggacag tgatcttggc accaactagg gttgtcgctg ctgagatgga 2640
ggaggccttg agaggacttc cggtgcgtta catgacaaca gcagtcaacg tcacccattc 2700
tgggacagaa atcgttgatt tgatgtgcca tgccactttc acttcacgct tactacaacc 2760
catcagagtc cctaattaca atctctacat catggatgaa gcccacttca cagacccctc 2820
aagtatagct gcaagaggat acatatcaac aagggttgaa atgggcgagg cggctgccat 2880
ttttatgact gccacaccac caggaacccg tgatgcgttt cctgactcta actcaccaat 2940
catggacaca gaagtggaag tcccagagag agcctggagc tcaggctttg attgggtgac 3000
agaccattct gggaaaacag tttggttcgt tccaagcgtg agaaacggaa atgaaatcgc 3060
agcctgtctg acaaaggctg gaaagcgggt catacagctc agcaggaaga cttttgagac 3120
agaatttcag aaaacaaaaa atcaagagtg ggactttgtc ataacaactg acatctcaga 3180
gatgggcgcc aacttcaagg ctgaccgggt catagactct aggagatgcc taaaaccagt 3240
catacttgat ggtgagagag tcatcttggc tgggcccatg cctgtcacgc atgctagtgc 3300
tgctcagagg agaggacgta taggcaggaa ccctaacaaa cctggagatg agtacatgta 3360
tggaggtggg tgtgcagaga ctgatgaagg ccatgcacac tggcttgaag caagaatgct 3420
tcttgacaac atctacctcc aggatggcct catagcctcg ctctatcggc ctgaggccga 3480
taaggtagcc gccattgagg gagagtttaa gctgaggaca gagcaaagga agaccttcgt 3540
ggaactcatg aagagaggag accttcccgt ctggctagcc tatcaggttg catctgccgg 3600
aataacttac acagacagaa gatggtgctt tgatggcaca accaacaaca ccataatgga 3660
agacagcgta ccagcagagg tgtggacaaa gtatggagag aagagagtgc tcaaaccgag 3720
atggatggat gctagggtct gttcagacca tgcggccctg aagtcgttca aagaattcgc 3780
cgctggaaaa agaggagcgg ctttgggagt aatggaggcc ctgggaacac tgccaggaca 3840
catgacagag aggtttcagg aagccattga caacctcgcc gtgctcatgc gagcagagac 3900
tggaagcagg ccttataagg cagcggcagc ccaactgccg gagaccctag agaccattat 3960
gctcttaggt ttgctgggaa cagtttcact ggggatcttc ttcgtcttga tgcggaataa 4020
gggcatcggg aagatgggct ttggaatggt aacccttggg gccagtgcat ggctcatgtg 4080
gctttcggaa attgaaccag ccagaattgc atgtgtcctc attgttgtgt ttttattact 4140
ggtggtgctc atacccgagc cagagaagca aagatctccc caagataacc agatggcaat 4200
tatcatcatg gtggcagtgg gccttctagg tttgataact gcaaacgaac ttggatggct 4260
ggaaagaaca aaaaatgaca tagctcatct aatgggaagg agagaagaag gagcaaccat 4320
gggattctca atggacattg atctgcggcc agcctccgcc tgggctatct atgccgcatt 4380
gacaactctc atcaccccag ctgtccaaca tgcggtaacc acttcataca acaactactc 4440
cttaatggcg atggccacac aagctggagt gctgtttggc atgggcaaag ggatgccatt 4500
ttatgcatgg gaccttggag tcccgctgct aatgatgggt tgctattcac aattaacacc 4560
cctgactctg atagtagcta tcattctgct tgtggcgcac tacatgtact tgatcccagg 4620
cctacaagcg gcagcagcgc gtgctgccca gaaaaggaca gcagctggca tcatgaagaa 4680
tcccgttgtg gatggaatag tggtaactga cattgacaca atgacaatag acccccaggt 4740
ggagaagaag atgggacaag tgttactcat agcagtagcc atctccagtg ctgtgctgct 4800
gcggaccgcc tggggatggg gggaggctgg agctctgatc acagcagcga cctccacctt 4860
gtgggaaggc tctccaaaca aatactggaa ctcctctaca gccacctcac tgtgcaacat 4920
cttcagagga agctatctgg caggagcttc ccttatctat acagtgacga gaaacgctgg 4980
cctggttaag agacgtggag gtgggacggg agagactctg ggagagaagt ggaaagctcg 5040
tctgaatcag atgtcggccc tggagttcta ctcttataaa aagtcaggta tcactgaagt 5100
gtgtagagag gaggctcgcc gtgccctcaa ggatggagtg gccacaggag gacatgccgt 5160
atcccgggga agtgcaaagc tcagatggtt ggtggagaga ggatatctgc agccctatgg 5220
gaaggttgtt gacctcggat gtggcagagg gggctggagc tattatgccg ccaccatccg 5280
caaagtgcag gaggtgagag gatacacaaa gggaggtccc ggtcatgaag aacccatgct 5340
ggtgcaaagc tatgggtgga acatagttcg tctcaagagt ggagtggacg tcttccacat 5400
ggcggctgag ccgtgtgaca ctctgctgtg tgacataggt gagtcatcat ctagtcctga 5460
agtggaagag acacgaacac tcagagtgct ctctatggtg ggggactggc ttgaaaaaag 5520
accaggggcc ttctgtataa aggtgctgtg cccatacacc agcactatga tggaaaccat 5580
ggagcgactg caacgtaggc atgggggagg attagtcaga gtgccattgt ctcgcaactc 5640
cacacatgag atgtactggg tctctggggc aaagagcaac atcataaaaa gtgtgtccac 5700
cacaagtcag ctcctcctgg gacgcatgga tggccccagg aggccagtga aatatgagga 5760
ggatgtgaac ctcggctcgg gtacacgagc tgtggcaagc tgtgctgagg ctcctaacat 5820
gaaaatcatc ggcaggcgca ttgagagaat ccgcaatgaa catgcagaaa catggtttct 5880
tgatgaaaac cacccataca ggacatgggc ctaccatggg agctacgaag cccccacgca 5940
aggatcagcg tcttccctcg tgaacggggt tgttagactc ctgtcaaagc cttgggacgt 6000
ggtgactgga gttacaggaa tagccatgac tgacaccaca ccatacggcc aacaaagagt 6060
cttcaaagaa aaagtggaca ccagggtgcc agatccccaa gaaggcactc gccaggtaat 6120
gaacatagtc tcttcctggc tgtggaagga gctggggaaa cgcaagcggc cacgcgtctg 6180
caccaaagaa gagtttatca acaaggtgcg cagcaatgca gcactgggag caatatttga 6240
agaggaaaaa gaatggaaga cggctgtgga agctgtgaat gatccaaggt tttgggccct 6300
agtggatagg gagagagaac accacctgag aggagagtgt cacagctgtg tgtacaacat 6360
gatgggaaaa agagaaaaga agcaaggaga gttcgggaaa gcaaaaggta gccgcgccat 6420
ctggtacatg tggttgggag ccagattctt ggagtttgaa gcccttggat tcttgaacga 6480
ggaccattgg atgggaagag aaaactcagg aggtggagtc gaagggttag gattgcaaag 6540
acttggatac attctagaag aaatgaatcg ggcaccagga ggaaagatgt acgcagatga 6600
cactgctggc tgggacaccc gcattagtaa gtttgatctg gagaatgaag ctctgattac 6660
caaccaaatg gaggaagggc acagaactct ggcgttggcc gtgattaaat acacatacca 6720
aaacaaagtg gtgaaggttc tcagaccagc tgaaggagga aaaacagtta tggacatcat 6780
ttcaagacaa gaccagagag ggagtggaca agttgtcact tatgctctca acacattcac 6840
caacttggtg gtgcagctta tccggaacat ggaagctgag gaagtgttag agatgcaaga 6900
cttatggttg ttgaggaagc cagagaaagt gaccagatgg ttgcagagca atggatggga 6960
tagactcaaa cgaatggcgg tcagtggaga tgactgcgtt gtgaagccaa tcgatgatag 7020
gtttgcacat gccctcaggt tcttgaatga catgggaaaa gttaggaaag acacacagga 7080
gtggaaaccc tcgactggat ggagcaattg ggaagaagtc ccgttctgct cccaccactt 7140
caacaagctg tacctcaagg atgggagatc cattgtggtc ccttgccgcc accaagatga 7200
actgattggc cgagctcgcg tctcaccagg ggcaggatgg agcatccggg agactgcctg 7260
tcttgcaaaa tcatatgcgc agatgtggca gctcctttat ttccacagaa gagaccttcg 7320
actgatggct aatgccattt gctcggctgt gccagttgac tgggtaccaa ctgggagaac 7380
cacctggtca atccatggaa agggagaatg gatgaccact gaggacatgc tcatggtgtg 7440
gaatagagtg tggattgagg agaacgacca tatggaggac aagactcctg taacaaaatg 7500
gacagacatt ccctatctag gaaaaaggga ggacttatgg tgtggatccc ttatagggca 7560
cagaccccgc accacttggg ctgaaaacat caaagacaca gtcaacatgg tgcgcaggat 7620
cataggtgat gaagaaaagt acatggacta tctatccacc caagtccgct acttgggtga 7680
ggaagggtcc acacccggag tgttgtaagc accaatttta gtgttgtcag gcctgctagt 7740
cagccacagt ttggggaaag ctgtgcagcc tgtaaccccc ccaggagaag ctgggaaacc 7800
aagctcatag tcaggccgag aacgccatgg cacggaagaa gccatgctgc ctgtgagccc 7860
ctcagaggac actgagtcaa aaaaccccac gcgcttggaa gcgcaggatg ggaaaagaag 7920
gtggcgacct tccccaccct tcaatctggg gcctgaactg gagactagct gtgaatctcc 7980
agcagaggga ctagtggtta gaggagaccc cccggaaaac gcaaaacagc atattgacgc 8040
tgggaaagac cagagactcc atgagtttcc accacgctgg ccgccaggca cagatcgccg 8100
aacttcggcg gccggtgtgg ggaaatccat ggtttct 8137
<210> 33
<211> 8137
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 33
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cacaccagag agggttacag 600
aacccaagtg aaagggccat ggcacagtga agagcttgaa atccggtttg aggaatgtcc 660
aggcaccaag gtttacgtgg aggagacatg cggaactaga ggaccatctc tgagatcaac 720
tactgcaagt ggaagggtca ttgaggaatg gtgctgtagg gaatgcacaa tgcccccact 780
atcgtttcga gcaaaagacg gctgctggta tggaatggag ataaggccca ggaaagaacc 840
agagagcaac ttagtgaggt caatggtgac agcggggtca accgatcata tggaccactt 900
ctctcttgga gtgcttgtga ttctactcat ggtgcaggag gggttgaaga agagaatgac 960
cacaaagatc atcatgagca catcaatggc agtgctggta gtcatgatct tgggaggatt 1020
ttcaatgagt gacctggcca agcttgtgat cctgatgggt gctactttcg cagaaatgaa 1080
cactggagga gatgtagctc acttggcatt ggtagcggca tttaaagtca gaccagcctt 1140
gctggtctcc ttcattttca gagccaattg gacaccccgt gagagcatgc tgctagccct 1200
ggcttcgtgt cttctgcaaa ctgcgatctc tgctcttgaa ggtgacttga tggtcctcat 1260
taatggattt gctttggcct ggttggcaat tcgagcaatg gccgtgccac gcactgacaa 1320
catcgctcta ccaatcttgg ctgctctaac accactagct cgaggcacac tgctcgtggc 1380
atggagagcg ggcctggcta cttgtggagg gatcatgctc ctctccctga aagggaaagg 1440
tagtgtgaag aagaacctgc catttgtcat ggccctggga ttgacagctg tgagggtagt 1500
agaccctatt aatgtggtag gactactgtt actcacaagg agtgggaagc ggagctggcc 1560
ccctagtgaa gttctcacag ccgttggcct gatatgtgca ctggccggag ggtttgccaa 1620
ggcagacatt gagatggctg gacccatggc tgcagtaggc ttgctaattg tcagctatgt 1680
ggtctcggga aagagtgtgg acatgtacat tgaaagagca ggtgacatca catgggaaaa 1740
ggacgcggaa gtcactggaa acagtcctcg gcttgacgtg gcactggatg agagtggtga 1800
tttctccttg gtagaggaag atggtccacc catgagagag atcatactca aggtggtcct 1860
gatggccatc tgtggcatga acccaatagc tatacctttt gctgcaggag cgtggtatgt 1920
gtatgtgaag actgggaaaa ggagtggcgc cctctgggac gtgcctgctc ccaaagaagt 1980
gaagaaagga gagaccacag atggagtgta cagagtgatg actcgcagac tgctaggttc 2040
aacacaggtt ggagtgggag tcatgcaaga gggagtcttc cacaccatgt ggcacgttac 2100
aaaaggagcc gcactgagga gcggtgaggg aagacttgat ccatactggg gggatgtcaa 2160
gcaggacttg gtgtcatact gtgggccttg gaagttggat gcagcttggg atggactcag 2220
cgaggtacag cttttggccg tacctcccgg agagagggcc agaaacattc agaccctgcc 2280
tggaatattc aagacaaagg acggggacat cggagcagtt gctctggact accctgcagg 2340
gacctcagga tctccgatcc tagacaaatg tggaagagtg ataggactct atggcaatgg 2400
ggttgtgatc aagaatggaa gctatgttag tgctataacc cagggaaaga gggaggagga 2460
gactccggtt gaatgtttcg aaccctcgat gctgaagaag aagcagctaa ctgtcttgga 2520
tctgcatcca ggagccggaa aaaccaggag agttcttcct gaaatagtcc gtgaagccat 2580
aaaaaagaga ctccggacag tgatcttggc accaactagg gttgtcgctg ctgagatgga 2640
ggaggccttg agaggacttc cggtgcgtta catgacaaca gcagtcaacg tcacccattc 2700
tgggacagaa atcgttgatt tgatgtgcca tgccactttc acttcacgct tactacaacc 2760
catcagagtc cctaattaca atctctacat catggatgaa gcccacttca cagacccctc 2820
aagtatagct gcaagaggat acatatcaac aagggttgaa atgggcgagg cggctgccat 2880
ttttatgact gccacaccac caggaacccg tgatgcgttt cctgactcta actcaccaat 2940
catggacaca gaagtggaag tcccagagag agcctggagc tcaggctttg attgggtgac 3000
agaccattct gggaaaacag tttggttcgt tccaagcgtg agaaacggaa atgaaatcgc 3060
agcctgtctg acaaaggctg gaaagcgggt catacagctc agcaggaaga cttttgagac 3120
agaatttcag aaaacaaaaa atcaagagtg ggactttgtc ataacaactg acatctcaga 3180
gatgggcgcc aacttcaagg ctgaccgggt catagactct aggagatgcc taaaaccagt 3240
catacttgat ggtgagagag tcatcttggc tgggcccatg cctgtcacgc atgctagtgc 3300
tgctcagagg agaggacgta taggcaggaa ccctaacaaa cctggagatg agtacatgta 3360
tggaggtggg tgtgcagaga ctgatgaagg ccatgcacac tggcttgaag caagaatgct 3420
tcttgacaac atctacctcc aggatggcct catagcctcg ctctatcggc ctgaggccga 3480
taaggtagcc gccattgagg gagagtttaa gctgaggaca gagcaaagga agaccttcgt 3540
ggaactcatg aagagaggag accttcccgt ctggctagcc tatcaggttg catctgccgg 3600
aataacttac acagacagaa gatggtgctt tgatggcaca accaacaaca ccataatgga 3660
agacagcgta ccagcagagg tgtggacaaa gtatggagag aagagagtgc tcaaaccgag 3720
atggatggat gctagggtct gttcagacca tgcggccctg aagtcgttca aagaattcgc 3780
cgctggaaaa agaggagcgg ctttgggagt aatggaggcc ctgggaacac tgccaggaca 3840
catgacagag aggtttcagg aagccattga caacctcgcc gtgctcatgc gagcagagac 3900
tggaagcagg ccttataagg cagcggcagc ccaactgccg gagaccctag agaccattat 3960
gctcttaggt ttgctgggaa cagtttcact ggggatcttc ttcgtcttga tgcggaataa 4020
gggcatcggg aagatgggct ttggaatggt aacccttggg gccagtgcat ggctcatgtg 4080
gctttcggaa attgaaccag ccagaattgc atgtgtcctc attgttgtgt ttttattact 4140
ggtggtgctc atacccgagc cagagaagca aagatctccc caagataacc agatggcaat 4200
tatcatcatg gtggcagtgg gccttctagg tttgataact gcaaacgaac ttggatggct 4260
ggaaagaaca aaaaatgaca tagctcatct aatgggaagg agagaagaag gagcaaccat 4320
gggattctca atggacattg atctgcggcc agcctccgcc tgggctatct atgccgcatt 4380
gacaactctc atcaccccag ctgtccaaca tgcggtaacc acttcataca acaactactc 4440
cttaatggcg atggccacac aagctggagt gctgtttggc atgggcaaag ggatgccatt 4500
ttatgcatgg gaccttggag tcccgctgct aatgatgggt tgctattcac aattaacacc 4560
cctgactctg atagtagcta tcattctgct tgtggcgcac tacatgtact tgatcccagg 4620
cctacaagcg gcagcagcgc gtgctgccca gaaaaggaca gcagctggca tcatgaagaa 4680
tcccgttgtg gatggaatag tggtaactga cattgacaca atgacaatag acccccaggt 4740
ggagaagaag atgggacaag tgttactcat agcagtagcc atctccagtg ctgtgctgct 4800
gcggaccgcc tggggatggg gggaggctgg agctctgatc acagcagcga cctccacctt 4860
gtgggaaggc tctccaaaca aatactggaa ctcctctaca gccacctcac tgtgcaacat 4920
cttcagagga agctatctgg caggagcttc ccttatctat acagtgacga gaaacgctgg 4980
cctggttaag agacgtggag gtgggacggg agagactctg ggagagaagt ggaaagctcg 5040
tctgaatcag atgtcggccc tggagttcta ctcttataaa aagtcaggta tcactgaagt 5100
gtgtagagag gaggctcgcc gtgccctcaa ggatggagtg gccacaggag gacatgccgt 5160
atcccgggga agtgcaaagc tcagatggtt ggtggagaga ggatatctgc agccctatgg 5220
gaaggttgtt gacctcggat gtggcagagg gggctggagc tattatgccg ccaccatccg 5280
caaagtgcag gaggtgagag gatacacaaa gggaggtccc ggtcatgaag aacccatgct 5340
ggtgcaaagc tatgggtgga acatagttcg tctcaagagt ggagtggacg tcttccacat 5400
ggcggctgag ccgtgtgaca ctctgctgtg tgacataggt gagtcatcat ctagtcctga 5460
agtggaagag acacgaacac tcagagtgct ctctatggtg ggggactggc ttgaaaaaag 5520
accaggggcc ttctgtataa aggtgctgtg cccatacacc agcactatga tggaaaccat 5580
ggagcgactg caacgtaggc atgggggagg attagtcaga gtgccattgt ctcgcaactc 5640
cacacatgag atgtactggg tctctggggc aaagagcaac atcataaaaa gtgtgtccac 5700
cacaagtcag ctcctcctgg gacgcatgga tggccccagg aggccagtga aatatgagga 5760
ggatgtgaac ctcggctcgg gtacacgagc tgtggcaagc tgtgctgagg ctcctaacat 5820
gaaaatcatc ggcaggcgca ttgagagaat ccgcaatgaa catgcagaaa catggtttct 5880
tgatgaaaac cacccataca ggacatgggc ctaccatggg agctacgaag cccccacgca 5940
aggatcagcg tcttccctcg tgaacggggt tgttagactc ctgtcaaagc cttgggacgt 6000
ggtgactgga gttacaggaa tagccatgac tgacaccaca ccatacggcc aacaaagagt 6060
cttcaaagaa aaagtggaca ccagggtgcc agatccccaa gaaggcactc gccaggtaat 6120
gaacatagtc tcttcctggc tgtggaagga gctggggaaa cgcaagcggc cacgcgtctg 6180
caccaaagaa gagtttatca acaaggtgcg cagcaatgca gcactgggag caatatttga 6240
agaggaaaaa gaatggaaga cggctgtgga agctgtgaat gatccaaggt tttgggccct 6300
agtggatagg gagagagaac accacctgag aggagagtgt cacagctgtg tgtacaacat 6360
gatgggaaaa agagaaaaga agcaaggaga gttcgggaaa gcaaaaggta gccgcgccat 6420
ctggtacatg tggttgggag ccagattctt ggagtttgaa gcccttggat tcttgaacga 6480
ggaccattgg atgggaagag aaaactcagg aggtggagtc gaagggttag gattgcaaag 6540
acttggatac attctagaag aaatgaatcg ggcaccagga ggaaagatgt acgcagatga 6600
cactgctggc tgggacaccc gcattagtaa gtttgatctg gagaatgaag ctctgattac 6660
caaccaaatg gaggaagggc acagaactct ggcgttggcc gtgattaaat acacatacca 6720
aaacaaagtg gtgaaggttc tcagaccagc tgaaggagga aaaacagtta tggacatcat 6780
ttcaagacaa gaccagagag ggagtggaca agttgtcact tatgctctca acacattcac 6840
caacttggtg gtgcagctta tccggaacat ggaagctgag gaagtgttag agatgcaaga 6900
cttatggttg ttgaggaagc cagagaaagt gaccagatgg ttgcagagca atggatggga 6960
tagactcaaa cgaatggcgg tcagtggaga tgactgcgtt gtgaagccaa tcgatgatag 7020
gtttgcacat gccctcaggt tcttgaatga catgggaaaa gttaggaaag acacacagga 7080
gtggaaaccc tcgactggat ggagcaattg ggaagaagtc ccgttctgct cccaccactt 7140
caacaagctg tacctcaagg atgggagatc cattgtggtc ccttgccgcc accaagatga 7200
actgattggc cgagctcgcg tctcaccagg ggcaggatgg agcatccggg agactgcctg 7260
tcttgcaaaa tcatatgcgc agatgtggca gctcctttat ttccacagaa gagaccttcg 7320
actgatggct aatgccattt gctcggctgt gccagttgac tgggtaccaa ctgggagaac 7380
cacctggtca atccatggaa agggagaatg gatgaccact gaggacatgc tcatggtgtg 7440
gaatagagtg tggattgagg agaacgacca tatggaggac aagactcctg taacaaaatg 7500
gacagacatt ccctatctag gaaaaaggga ggacttatgg tgtggatccc ttatagggca 7560
cagaccccgc accacttggg ctgaaaacat caaagacaca gtcaacatgg tgcgcaggat 7620
cataggtgat gaagaaaagt acatggacta tctatccacc caagtccgct acttgggtga 7680
ggaagggtcc acacccggag tgttgtaagc accaatttta gtgttgtcag gcctgctagt 7740
cagccacagt ttggggaaag ctgtgcagcc tgtaaccccc ccaggagaag ctgggaaacc 7800
aagctcatag tcaggccgag aacgccatgg cacggaagaa gccatgctgc ctgtgagccc 7860
ctcagaggac actgagtcaa aaaaccccac gcgcttggaa gcgcaggatg ggaaaagaag 7920
gtggcgacct tccccaccct tcaatctggg gcctgaactg gagactagct gtgaatctcc 7980
agcagaggga ctagtggtta gaggagaccc cccggaaaac gcaaaacagc atattgacgc 8040
tgggaaagac cagagactcc atgagtttcc accacgctgg ccgccaggca cagatcgccg 8100
aacttcggcg gccggtgtgg ggaaatccat ggtttct 8137
<210> 34
<211> 9163
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 34
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacgagctt ggtccctatc ctcgaaacag cggggataaa actaaatgat 480
aggcagtggt ctcagataat tcaagccttc aaagaagaca aagcatactc acctgaagta 540
gccctgaatg aaatatgtac gcgcatgtat ggggtggatc tagacagcgg gctattttct 600
aaaccgttgg tgtctgtgta ttacgcggat aaccactggg ataataggcc tggagggaaa 660
atgttcggat ttaaccccga ggcagcatcc attctagaaa gaaagtatcc attcacaaaa 720
gggaagtgga acatcaacaa gcagatctgc gtgactacca ggaggataga agactttaac 780
cctaccacca acatcatacc ggccaacagg agactaccac actcattagt ggccgaacac 840
cgcccagtaa aaggggaaag aatggaatgg ctggttaaca agataaacgg ccaccacgtg 900
ctcctggtca gtggctataa ccttgcactg cctactaaga gagtcacttg ggtagcgccg 960
ttaggtgtcc gtggagcgga ctacacatac aacctagagt tgggtctgcc agcaacgctt 1020
ggtaggtatg acctagtggt cataaacatc cacacacctt ttcgcataca ccattaccaa 1080
cagtgcgtcg accacgcaat gaaactgcaa atgctcgggg gtgactcatt gagactgctc 1140
aaaccgggcg gctctctatt gatcagagca tatggttacg cagatagaac cagtgaacga 1200
gtcatctgcg tattgggacg caagtttaga tcgtctagag cgttgaaacc accatgtgtc 1260
accagcaaca ctgagatgtt tttcctattc agcaactttg acaatggcag aaggaatttc 1320
acaactcatg tcatgaacaa tcaactgaat gcagccttcg taggacaggt cacccgagca 1380
ggatgtgcac cgtcgtaccg ggtaaaacgc atggacatcg cgaagaacga tgaagagtgc 1440
gtagtcaacg ccgctaaccc tcgcgggtta ccgggtgacg gtgtttgcaa ggcagtatac 1500
aaaaaatggc cggagtcctt taagaacagt gcaacaccag tgggaaccgc aaaaacagtt 1560
atgtgcggta cgtatccagt aatccacgct gttggaccaa acttctctaa ttattcggag 1620
tctgaagggg accgggaatt ggcagctgcc tatcgagaag tcgcaaagga agtaactagg 1680
ctgggagtaa atagtgtagc tatacctctc ctctccacag gtgtatactc aggagggaaa 1740
gacaggctga cccagtcact gaaccacctc tttacagcca tggactcgac ggatgcagac 1800
gtggtcatct actgccgcga caaagaatgg gagaagaaaa tatctgaggc catacagatg 1860
cggacccaag tagagctgct ggatgagcac atctccatag actgcgatat tgttcgcgtg 1920
caccctgaca gcagcttggc aggcagaaaa ggatacagca ccacggaagg cgcactgtac 1980
tcatatctag aagggacccg ttttcatcag acggctgtgg atatggcgga gatacatact 2040
atgtggccaa agcaaacaga ggccaatgag caagtctgcc tatatgccct gggggaaagt 2100
attgaatcga tcaggcagaa atgcccggtg gatgatgcag acgcatcatc tccccccaaa 2160
actgtcccgt gcctttgccg ttacgctatg actccagaac gcgtcacccg gcttcgcatg 2220
aaccacgtca caagcataat tgtgtgttct tcgtttcccc tcccaaagta caaaatagaa 2280
ggagtgcaaa aagtcaaatg ctctaaggta atgctatttg accacaacgt gccatcgcgc 2340
gtaagtccaa gggaatatag atcttcccag gagtctgcac aggaggcgag tacaatcacg 2400
tcactgacgc atagtcaatt cgacctaagc gttgatggcg agatactgcc cgtcccgtca 2460
gacctggatg ctgacgcccc agccctagaa ccagcactag acgacggggc gacacacacg 2520
ctgccatcca caaccggaaa ccttgcggcc gtgtctgatt gggtaatgag caccgtacct 2580
gtcgcgccgc ccagaagaag gcgagggaga aacctgactg tgacatgtga cgagagagaa 2640
gggaatataa cacccatggc tagcgtccga ttctttaggg cagagctgtg tccggtcgta 2700
caagaaacag cggagacgcg tgacacagca atgtctcttc aggcaccacc gagtaccgcc 2760
acggaaccga atcatccgcc gatctccttc ggagcatcaa gcgagacgtt ccccattaca 2820
tttggggact tcaacgaagg agaaatcgaa agcttgtctt ctgagctact aactttcgga 2880
gacttcttac caggagaagt ggatgacttg acagacagcg actggtccac gtgctcagac 2940
acggacgacg agttatgact agacagggca ggtgggtata tattctcgtc ggacaccggt 3000
ccaggtcatt tacaacagaa gtcagtacgc cagtcagtgc tgccggtgaa caccctggag 3060
gaagtccacg aggagaagtg ttacccacct aagctggatg aagcaaagga gcaactatta 3120
cttaagaaac tccaggagag tgcatccatg gccaacagaa gcaggtatca gtcgcgcaaa 3180
gtagaaaaca tgaaagcagc aatcatccag agactaaaga gaggctgtag actatactta 3240
atgtcagaga ccccaaaagt ccctacttac cggactacat atccggcgcc tgtgtactcg 3300
cctccgatca acgtccgatt gtccaatccc gagtccgcag tggcagcatg caatgagttc 3360
ttagctagaa actatccaac tgtctcatca taccaaatta ccgacgagta tgatgcatat 3420
ctagacatgg tggacgggtc ggagagttgc ctggaccgag cgacattcaa tccgtcaaaa 3480
ctcaggagct acccgaaaca gcacgcttac cacgcgccct ccatcagaag cgctgtaccg 3540
tccccattcc agaacacact acagaatgta ctggcagcag ccacgaaaag aaactgcaac 3600
gtcacacaga tgagggaatt acccactttg gactcagcag tattcaacgt ggagtgtttc 3660
aaaaaattcg catgcaacca agaatactgg gaagaatttg ctgccagccc tattaggata 3720
acaactgaga atttagcaac ctatgttact aaactaaaag ggccaaaagc agcagcgcta 3780
ttcgcaaaaa cccataatct actgccacta caggaagtac caatggatag gttcacagta 3840
gatatgaaaa gggacgtaaa ggtgactcct ggtacaaagc atacagagga aagacctaag 3900
gtgcaggtta tacaggcggc tgaacccttg gcgacagcat acctatgtgg gattcacaga 3960
gagctggtta ggaggctgaa cgccgtcctc ctacccaatg tacatacact atttgacatg 4020
tctgccgagg atttcgatgc catcatagcc gcacacttta agccaggaga cactgttttg 4080
gaaacggaca tagcctcctt tgataagagc caagatgatt cacttgcgct tactgctttg 4140
atgctgttag aggatttagg ggtggatcac tccctgctgg acttgataga ggctgctttc 4200
ggagagattt ccagctgtca cctaccgaca ggtacgcgct tcaagttcgg cgccatgatg 4260
aaatcaggta tgttcctaac tctgttcgtc aacacattgt taaacatcac catcgccagc 4320
cgagtgctgg aagatcgtct gacaaaatcc gcgtgcgcgg ccttcatcgg cgacgacaac 4380
ataatacatg gagtcgtctc cgatgaattg atggcagcca gatgtgccac ttggatgaac 4440
atggaagtga agatcataga tgcagttgta tccttgaaag ccccttactt ttgtggaggg 4500
tttatactgc acgatactgt gacaggaaca gcttgcagag tggcagaccc gctaaaaagg 4560
ctttttaaac tgggcaaacc gctagcggca ggtgacgaac aagatgaaga tagaagacga 4620
gcgctggctg acgaagtgat cagatggcaa cgaacagggc taattgatga gctggagaaa 4680
gcggtatact ctaggtacga agtgcagggt atatcagttg tggtaatgtc catggccacc 4740
tttgcaagct ccagatccaa cttcgagaag ctcagaggac ccgtcataac tttgtacggc 4800
ggtcctaaat aggtacgcac tacagctacc tattttgcag aagccgacag caagtatcta 4860
aacactaatc agctacaatg gagttcatcc caacccaaac tttttacaat aggaggtacc 4920
agcctcgacc ctggactccg cgccctacta tccaagtcat caggcccaga ccgcgccctc 4980
agaggcaagc tgggcaactt gcccagctga tctcagcagt taataaactg acaatgcgcg 5040
cggtacccca acagaagcca cgcaggaatc ggaagaataa gaagcaaaag caaaaacaac 5100
aggcgccaca aaacaacaca aatcaaaaga agcagccacc taaaaagaaa ccggctcaaa 5160
agaaaaagaa gccgggccgc agagagagga tgtgcatgaa aatcgaaaat gattgtattt 5220
tcgaagtcaa gcacgaaggt aaggtaacag gttacgcgtg cctggtgggg gacaaagtaa 5280
tgaaaccagc acacgtaaag gggaccatcg ataacgcgga cctggccaaa ctggccttta 5340
agcggtcatc taagtatgac cttgaatgcg cgcagatacc cgtgcacatg aagtccgacg 5400
cttcgaagtt cacccatgag aaaccggagg ggtactacaa ctggcaccac ggagcagtac 5460
agtactcagg aggccggttc accatcccta caggtgctgg caaaccaggg gacagcggca 5520
gaccgatctt cgacaacaag ggacgcgtgg tggccatagt cttaggagga gctaatgaag 5580
gagcccgtac agccctctcg gtggtgacct ggaataaaga cattgtcact aaaatcaccc 5640
ccgagggggc cgaagagtgg agtcttgcca tcccagttat gtgcctgttg gcaaacacca 5700
cgttcccctg ctcccagccc ccttgcacgc cctgctgcta cgaaaaggaa ccggaggaaa 5760
ccctacgcat gcttgaggac aacgtcatga gacctgggta ctatcagctg ctacaagcat 5820
ccttaacatg ttctccccac cgccagcgac gcagcaccaa ggacaacttc aatgtctata 5880
aagccacaag accatactta gctcactgtc ccgactgtgg agaagggcac tcgtgccata 5940
gtcccgtagc actagaacgc atcagaaatg aagcgacaga cgggacgctg aaaatccagg 6000
tctccttgca aatcggaata aagacggatg acagccacga ttggaccaag ctgcgttata 6060
tggacaacca catgccagca gacgcagaga gggcggggct atttgtaaga acatcagcac 6120
cgtgtacgat tactggaaca atgggacact tcatcctggc ccgatgtcca aaaggggaaa 6180
ctctgacggt gggattcact gacagtagga agattagtca ctcatgtacg cacccatttc 6240
accacgaccc tcctgtgata ggtcgggaaa aattccattc ccgaccgcag cacggtaaag 6300
agctaccttg cagcacgtac gtgcagagca ccgccgcaac taccgaggag atagaggtac 6360
acatgccccc agacacccct gatcgcacat taatgtcaca acagtccggc aacgtaaaga 6420
tcacagtcaa tggccagacg gtgcggtaca agtgtaattg cggtggctca aatgaaggac 6480
taacaactac agacaaagtg attaataact gcaaggttga tcaatgtcat gccgcggtca 6540
ccaatcacaa aaagtggcag tataactccc ctctggtccc gcgtaatgct gaacttgggg 6600
accgaaaagg aaaaattcac atcccgtttc cgctggcaaa tgtaacatgc agggtgccta 6660
aagcaaggaa ccccaccgtg acgtacggga aaaaccaagt catcatgcta ctgtatcctg 6720
accacccaac actcctgtcc taccggaata tgggagaaga accaaactat caagaagagt 6780
gggtgatgca taagaaggaa gtcgtgctaa ccgtgccgac tgaagggctc gaggtcacgt 6840
ggggcaacaa cgagccgtat aagtattggc cgcagttatc tacaaacggt acagcccatg 6900
gccacccgca cgagataatt ctgtattatt atgagctgta ccccactatg actgtagtag 6960
ttgtgtcagt ggccacgttc atactcctgt cgatggtggg tatggcagcg gggatgtgca 7020
tgtgtgcacg acgcagatgc atcacaccgt atgaactgac accaggagct accgtccctt 7080
tcctgcttag cctaatatgc tgcatcagaa cagctaaagc ggccacatac caagaggctg 7140
cgatatacct gtggaacgag cagcaacctt tgttttggct acaagccctt attccgctgg 7200
cagccctgat tgttctatgc aactgtctga gactcttacc atgctgctgt aaaacgttgg 7260
cttttttagc cgtaatgagc gtcggtgccc acactgtgag cgcgtacgaa cacgtaacag 7320
tgatcccgaa cacggtggga gtaccgtata agactctagt caatagacct ggctacagcc 7380
ccatggtatt ggagatggaa ctactgtcag tcactttgga gccaacacta tcgcttgatt 7440
acatcacgtg cgagtacaaa accgtcatcc cgtctccgta cgtgaagtgc tgcggtacag 7500
cagagtgcaa ggacaaaaac ctacctgact acagctgtaa ggtcttcacc ggcgtctacc 7560
catttatgtg gggcggcgcc tactgcttct gcgacgctga aaacacgcag ttgagcgaag 7620
cacacgtgga gaagtccgaa tcatgcaaaa cagaatttgc atcagcatac agggctcata 7680
ccgcatctgc atcagctaag ctccgcgtcc tttaccaagg aaataacatc actgtaactg 7740
cctatgcaaa cggcgaccat gccgtcacag ttaaggacgc caaattcatt gtggggccaa 7800
tgtcttcagc ctggacacct ttcgacaaca aaattgtggt gtacaaaggt gacgtctata 7860
acatggacta cccgcccttt ggcgcaggaa gaccaggaca atttggcgat atccaaagtc 7920
gcacacctga gagtaaagac gtctatgcta atacacaact ggtactgcag agaccggctg 7980
tgggtacggt acacgtgcca tactctcagg caccatctgg ctttaagtat tggctaaaag 8040
aacgcggggc gtcgctgcag cacacagcac catttggctg ccaaatagca acaaacccgg 8100
taagagcggt gaactgcgcc gtagggaaca tgcccatctc catcgacata ccggaagcgg 8160
ccttcactag ggtcgtcgac gcgccctctt taacggacat gtcgtgcgag gtaccagcct 8220
gcacccattc ctcagacttt gggggcgtcg ccattattaa atatgcagcc agcaagaaag 8280
gcaagtgtgc ggtgcattcg atgactaacg ccgtcactat tcgggaagct gagatagaag 8340
ttgaagggaa ttctcagctg caaatctctt tctcgacggc cttagccagc gccgaattcc 8400
gcgtacaagt ctgttctaca caagtacact gtgcagccga gtgccacccc ccgaaggacc 8460
acatagtcaa ctacccggcg tcacatacca ccctcggggt ccaggacatc tccgctacgg 8520
cgatgtcatg ggtgcagaag atcacgggag gtgtgggact ggttgttgct gttgccgcac 8580
tgattctaat cgtggtgcta tgcgtgtcgt tcagcaggca ctaacttgac aattaagtat 8640
gaaggtatat gtgtccccta agagacacac tgtacatagc aaataatcta tagatcaaag 8700
ggctacgcaa cccctgaata gtaacaaaat ataaaatcac taaaaattat aaaaacagaa 8760
aaatacataa ataggtatac gtgtccccta agagacacat tgtatgtagg tgataagtat 8820
agatcaaagg gccgaataac ccctgaatag taacaaaata tgaaaatcaa taaaaatcat 8880
aaaatagaaa aaccataaac agaagtagtt caaagggcta taaaacccct gaatagtaac 8940
aaaacataaa attaataaaa atcaaatgaa taccataatt ggcaaacgga agagatgtag 9000
gtacttaagc ttcctaaaag cagccgaact cactttgaga agtaggcata gcataccgaa 9060
ctcttccacg attctccgaa cccacaggga cgtaggagat gttattttgt ttttaatatt 9120
tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 9163
<210> 35
<211> 9636
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 35
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctaacccgct ctatgcatca acgtcagagc acgtcaacgt actcctaacg cgtacggaag 720
gtaaactggt atggaagaca ctttccggcg acccgtggat aaagacgctg cagaacccac 780
cgaaaggaaa cttcaaagca actattaagg agtgggaggt ggagcatgca tcaataatgg 840
cgggcatctg cagtcaccaa atgaccttcg atacattcca aaataaagcc aacgtttgtt 900
gggctaagag cttggtccct atcctcgaaa cagcggggat aaaactaaat gataggcagt 960
ggtctcagat aattcaagcc ttcaaagaag acaaagcata ctcacctgaa gtagccctga 1020
atgaaatatg tacgcgcatg tatggggtgg atctagacag cgggctattt tctaaaccgt 1080
tggtgtctgt gtattacgcg gataaccact gggataatag gcctggaggg aaaatgttcg 1140
gatttaaccc cgaggcagca tccattctag aaagaaagta tccattcaca aaagggaagt 1200
ggaacatcaa caagcagatc tgcgtgacta ccaggaggat agaagacttt aaccctacca 1260
ccaacatcat accggccaac aggagactac cacactcatt agtggccgaa caccgcccag 1320
taaaagggga aagaatggaa tggctggtta acaagataaa cggccaccac gtgctcctgg 1380
tcagtggcta taaccttgca ctgcctacta agagagtcac ttgggtagcg ccgttaggtg 1440
tccgtggagc ggactacaca tacaacctag agttgggtct gccagcaacg cttggtaggt 1500
atgacctagt ggtcataaac atccacacac cttttcgcat acaccattac caacagtgcg 1560
tcgaccacgc aatgaaactg caaatgctcg ggggtgactc attgagactg ctcaaaccgg 1620
gcggctctct attgatcaga gcatatggtt acgcagatag aaccagtgaa cgagtcatct 1680
gcgtattggg acgcaagttt agatcgtcta gagcgttgaa accaccatgt gtcaccagca 1740
acactgagat gtttttccta ttcagcaact ttgacaatgg cagaaggaat ttcacaactc 1800
atgtcatgaa caatcaactg aatgcagcct tcgtaggaca ggtcacccga gcaggatgtg 1860
caccgtcgta ccgggtaaaa cgcatggaca tcgcgaagaa cgatgaagag tgcgtagtca 1920
acgccgctaa ccctcgcggg ttaccgggtg acggtgtttg caaggcagta tacaaaaaat 1980
ggccggagtc ctttaagaac agtgcaacac cagtgggaac cgcaaaaaca gttatgtgcg 2040
gtacgtatcc agtaatccac gctgttggac caaacttctc taattattcg gagtctgaag 2100
gggaccggga attggcagct gcctatcgag aagtcgcaaa ggaagtaact aggctgggag 2160
taaatagtgt agctatacct ctcctctcca caggtgtata ctcaggaggg aaagacaggc 2220
tgacccagtc actgaaccac ctctttacag ccatggactc gacggatgca gacgtggtca 2280
tctactgccg cgacaaagaa tgggagaaga aaatatctga ggccatacag atgcggaccc 2340
aagtagagct gctggatgag cacatctcca tagactgcga tattgttcgc gtgcaccctg 2400
acagcagctt ggcaggcaga aaaggataca gcaccacgga aggcgcactg tactcatatc 2460
tagaagggac ccgttttcat cagacggctg tggatatggc ggagatacat actatgtggc 2520
caaagcaaac agaggccaat gagcaagtct gcctatatgc cctgggggaa agtattgaat 2580
cgatcaggca gaaatgcccg gtggatgatg cagacgcatc atctcccccc aaaactgtcc 2640
cgtgcctttg ccgttacgct atgactccag aacgcgtcac ccggcttcgc atgaaccacg 2700
tcacaagcat aattgtgtgt tcttcgtttc ccctcccaaa gtacaaaata gaaggagtgc 2760
aaaaagtcaa atgctctaag gtaatgctat ttgaccacaa cgtgccatcg cgcgtaagtc 2820
caagggaata tagatcttcc caggagtctg cacaggaggc gagtacaatc acgtcactga 2880
cgcatagtca attcgaccta agcgttgatg gcgagatact gcccgtcccg tcagacctgg 2940
atgctgacgc cccagcccta gaaccagcac tagacgacgg ggcgacacac acgctgccat 3000
ccacaaccgg aaaccttgcg gccgtgtctg attgggtaat gagcaccgta cctgtcgcgc 3060
cgcccagaag aaggcgaggg agaaacctga ctgtgacatg tgacgagaga gaagggaata 3120
taacacccat ggctagcgtc cgattcttta gggcagagct gtgtccggtc gtacaagaaa 3180
cagcggagac gcgtgacaca gcaatgtctc ttcaggcacc accgagtacc gccacggaac 3240
cgaatcatcc gccgatctcc ttcggagcat caagcgagac gttccccatt acatttgggg 3300
acttcaacga aggagaaatc gaaagcttgt cttctgagct actaactttc ggagacttct 3360
taccaggaga agtggatgac ttgacagaca gcgactggtc cacgtgctca gacacggacg 3420
acgagttatg actagacagg gcaggtgggt atatattctc gtcggacacc ggtccaggtc 3480
atttacaaca gaagtcagta cgccagtcag tgctgccggt gaacaccctg gaggaagtcc 3540
acgaggagaa gtgttaccca cctaagctgg atgaagcaaa ggagcaacta ttacttaaga 3600
aactccagga gagtgcatcc atggccaaca gaagcaggta tcagtcgcgc aaagtagaaa 3660
acatgaaagc agcaatcatc cagagactaa agagaggctg tagactatac ttaatgtcag 3720
agaccccaaa agtccctact taccggacta catatccggc gcctgtgtac tcgcctccga 3780
tcaacgtccg attgtccaat cccgagtccg cagtggcagc atgcaatgag ttcttagcta 3840
gaaactatcc aactgtctca tcataccaaa ttaccgacga gtatgatgca tatctagaca 3900
tggtggacgg gtcggagagt tgcctggacc gagcgacatt caatccgtca aaactcagga 3960
gctacccgaa acagcacgct taccacgcgc cctccatcag aagcgctgta ccgtccccat 4020
tccagaacac actacagaat gtactggcag cagccacgaa aagaaactgc aacgtcacac 4080
agatgaggga attacccact ttggactcag cagtattcaa cgtggagtgt ttcaaaaaat 4140
tcgcatgcaa ccaagaatac tgggaagaat ttgctgccag ccctattagg ataacaactg 4200
agaatttagc aacctatgtt actaaactaa aagggccaaa agcagcagcg ctattcgcaa 4260
aaacccataa tctactgcca ctacaggaag taccaatgga taggttcaca gtagatatga 4320
aaagggacgt aaaggtgact cctggtacaa agcatacaga ggaaagacct aaggtgcagg 4380
ttatacaggc ggctgaaccc ttggcgacag catacctatg tgggattcac agagagctgg 4440
ttaggaggct gaacgccgtc ctcctaccca atgtacatac actatttgac atgtctgccg 4500
aggatttcga tgccatcata gccgcacact ttaagccagg agacactgtt ttggaaacgg 4560
acatagcctc ctttgataag agccaagatg attcacttgc gcttactgct ttgatgctgt 4620
tagaggattt aggggtggat cactccctgc tggacttgat agaggctgct ttcggagaga 4680
tttccagctg tcacctaccg acaggtacgc gcttcaagtt cggcgccatg atgaaatcag 4740
gtatgttcct aactctgttc gtcaacacat tgttaaacat caccatcgcc agccgagtgc 4800
tggaagatcg tctgacaaaa tccgcgtgcg cggccttcat cggcgacgac aacataatac 4860
atggagtcgt ctccgatgaa ttgatggcag ccagatgtgc cacttggatg aacatggaag 4920
tgaagatcat agatgcagtt gtatccttga aagcccctta cttttgtgga gggtttatac 4980
tgcacgatac tgtgacagga acagcttgca gagtggcaga cccgctaaaa aggcttttta 5040
aactgggcaa accgctagcg gcaggtgacg aacaagatga agatagaaga cgagcgctgg 5100
ctgacgaagt gatcagatgg caacgaacag ggctaattga tgagctggag aaagcggtat 5160
actctaggta cgaagtgcag ggtatatcag ttgtggtaat gtccatggcc acctttgcaa 5220
gctccagatc caacttcgag aagctcagag gacccgtcat aactttgtac ggcggtccta 5280
aataggtacg cactacagct acctattttg cagaagccga cagcaagtat ctaaacacta 5340
atcagctaca atggagttca tcccaaccca aactttttac aataggaggt accagcctcg 5400
accctggact ccgcgcccta ctatccaagt catcaggccc agaccgcgcc ctcagaggca 5460
agctgggcaa cttgcccagc tgatctcagc agttaataaa ctgacaatgc gcgcggtacc 5520
ccaacagaag ccacgcagga atcggaagaa taagaagcaa aagcaaaaac aacaggcgcc 5580
acaaaacaac acaaatcaaa agaagcagcc acctaaaaag aaaccggctc aaaagaaaaa 5640
gaagccgggc cgcagagaga ggatgtgcat gaaaatcgaa aatgattgta ttttcgaagt 5700
caagcacgaa ggtaaggtaa caggttacgc gtgcctggtg ggggacaaag taatgaaacc 5760
agcacacgta aaggggacca tcgataacgc ggacctggcc aaactggcct ttaagcggtc 5820
atctaagtat gaccttgaat gcgcgcagat acccgtgcac atgaagtccg acgcttcgaa 5880
gttcacccat gagaaaccgg aggggtacta caactggcac cacggagcag tacagtactc 5940
aggaggccgg ttcaccatcc ctacaggtgc tggcaaacca ggggacagcg gcagaccgat 6000
cttcgacaac aagggacgcg tggtggccat agtcttagga ggagctaatg aaggagcccg 6060
tacagccctc tcggtggtga cctggaataa agacattgtc actaaaatca cccccgaggg 6120
ggccgaagag tggagtcttg ccatcccagt tatgtgcctg ttggcaaaca ccacgttccc 6180
ctgctcccag cccccttgca cgccctgctg ctacgaaaag gaaccggagg aaaccctacg 6240
catgcttgag gacaacgtca tgagacctgg gtactatcag ctgctacaag catccttaac 6300
atgttctccc caccgccagc gacgcagcac caaggacaac ttcaatgtct ataaagccac 6360
aagaccatac ttagctcact gtcccgactg tggagaaggg cactcgtgcc atagtcccgt 6420
agcactagaa cgcatcagaa atgaagcgac agacgggacg ctgaaaatcc aggtctcctt 6480
gcaaatcgga ataaagacgg atgacagcca cgattggacc aagctgcgtt atatggacaa 6540
ccacatgcca gcagacgcag agagggcggg gctatttgta agaacatcag caccgtgtac 6600
gattactgga acaatgggac acttcatcct ggcccgatgt ccaaaagggg aaactctgac 6660
ggtgggattc actgacagta ggaagattag tcactcatgt acgcacccat ttcaccacga 6720
ccctcctgtg ataggtcggg aaaaattcca ttcccgaccg cagcacggta aagagctacc 6780
ttgcagcacg tacgtgcaga gcaccgccgc aactaccgag gagatagagg tacacatgcc 6840
cccagacacc cctgatcgca cattaatgtc acaacagtcc ggcaacgtaa agatcacagt 6900
caatggccag acggtgcggt acaagtgtaa ttgcggtggc tcaaatgaag gactaacaac 6960
tacagacaaa gtgattaata actgcaaggt tgatcaatgt catgccgcgg tcaccaatca 7020
caaaaagtgg cagtataact cccctctggt cccgcgtaat gctgaacttg gggaccgaaa 7080
aggaaaaatt cacatcccgt ttccgctggc aaatgtaaca tgcagggtgc ctaaagcaag 7140
gaaccccacc gtgacgtacg ggaaaaacca agtcatcatg ctactgtatc ctgaccaccc 7200
aacactcctg tcctaccgga atatgggaga agaaccaaac tatcaagaag agtgggtgat 7260
gcataagaag gaagtcgtgc taaccgtgcc gactgaaggg ctcgaggtca cgtggggcaa 7320
caacgagccg tataagtatt ggccgcagtt atctacaaac ggtacagccc atggccaccc 7380
gcacgagata attctgtatt attatgagct gtaccccact atgactgtag tagttgtgtc 7440
agtggccacg ttcatactcc tgtcgatggt gggtatggca gcggggatgt gcatgtgtgc 7500
acgacgcaga tgcatcacac cgtatgaact gacaccagga gctaccgtcc ctttcctgct 7560
tagcctaata tgctgcatca gaacagctaa agcggccaca taccaagagg ctgcgatata 7620
cctgtggaac gagcagcaac ctttgttttg gctacaagcc cttattccgc tggcagccct 7680
gattgttcta tgcaactgtc tgagactctt accatgctgc tgtaaaacgt tggctttttt 7740
agccgtaatg agcgtcggtg cccacactgt gagcgcgtac gaacacgtaa cagtgatccc 7800
gaacacggtg ggagtaccgt ataagactct agtcaataga cctggctaca gccccatggt 7860
attggagatg gaactactgt cagtcacttt ggagccaaca ctatcgcttg attacatcac 7920
gtgcgagtac aaaaccgtca tcccgtctcc gtacgtgaag tgctgcggta cagcagagtg 7980
caaggacaaa aacctacctg actacagctg taaggtcttc accggcgtct acccatttat 8040
gtggggcggc gcctactgct tctgcgacgc tgaaaacacg cagttgagcg aagcacacgt 8100
ggagaagtcc gaatcatgca aaacagaatt tgcatcagca tacagggctc ataccgcatc 8160
tgcatcagct aagctccgcg tcctttacca aggaaataac atcactgtaa ctgcctatgc 8220
aaacggcgac catgccgtca cagttaagga cgccaaattc attgtggggc caatgtcttc 8280
agcctggaca cctttcgaca acaaaattgt ggtgtacaaa ggtgacgtct ataacatgga 8340
ctacccgccc tttggcgcag gaagaccagg acaatttggc gatatccaaa gtcgcacacc 8400
tgagagtaaa gacgtctatg ctaatacaca actggtactg cagagaccgg ctgtgggtac 8460
ggtacacgtg ccatactctc aggcaccatc tggctttaag tattggctaa aagaacgcgg 8520
ggcgtcgctg cagcacacag caccatttgg ctgccaaata gcaacaaacc cggtaagagc 8580
ggtgaactgc gccgtaggga acatgcccat ctccatcgac ataccggaag cggccttcac 8640
tagggtcgtc gacgcgccct ctttaacgga catgtcgtgc gaggtaccag cctgcaccca 8700
ttcctcagac tttgggggcg tcgccattat taaatatgca gccagcaaga aaggcaagtg 8760
tgcggtgcat tcgatgacta acgccgtcac tattcgggaa gctgagatag aagttgaagg 8820
gaattctcag ctgcaaatct ctttctcgac ggccttagcc agcgccgaat tccgcgtaca 8880
agtctgttct acacaagtac actgtgcagc cgagtgccac cccccgaagg accacatagt 8940
caactacccg gcgtcacata ccaccctcgg ggtccaggac atctccgcta cggcgatgtc 9000
atgggtgcag aagatcacgg gaggtgtggg actggttgtt gctgttgccg cactgattct 9060
aatcgtggtg ctatgcgtgt cgttcagcag gcactaactt gacaattaag tatgaaggta 9120
tatgtgtccc ctaagagaca cactgtacat agcaaataat ctatagatca aagggctacg 9180
caacccctga atagtaacaa aatataaaat cactaaaaat tataaaaaca gaaaaataca 9240
taaataggta tacgtgtccc ctaagagaca cattgtatgt aggtgataag tatagatcaa 9300
agggccgaat aacccctgaa tagtaacaaa atatgaaaat caataaaaat cataaaatag 9360
aaaaaccata aacagaagta gttcaaaggg ctataaaacc cctgaatagt aacaaaacat 9420
aaaattaata aaaatcaaat gaataccata attggcaaac ggaagagatg taggtactta 9480
agcttcctaa aagcagccga actcactttg agaagtaggc atagcatacc gaactcttcc 9540
acgattctcc gaacccacag ggacgtagga gatgttattt tgtttttaat atttcaaaaa 9600
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 9636
<210> 36
<211> 4235
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 36
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctcgacaaac tgggcagatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgacg gaaggtagac gaggcaagtt gtctattatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctctac ccggaaagcc gcaagctact 840
taagagctgg cacctgccat cggtgttcca tttaaagggc aaactcagct tcacatgccg 900
ctgtgataca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacag ggtatgcggt aacccaccac gcagacggat tcctgatgtg 1020
caagactacc gacacggttg acggcgaaag agtgtcattc tcggtgtgca catacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
tacgaacacc atgaaaaatt atctgcttcc cgtggtcgcc caagccttca gtaagtgggc 1260
aaaggagtgc cggaaagaca tggaagatga aaaactcctg ggggtcagag aaagaacact 1320
gacctgctgc tgtctatggg cattcaagaa gcagaaaaca cacacggtct acaagagacc 1380
tgatacccag tcaattcaga aggttcaggc cgagtttgac agctttgtgg taccgagtct 1440
gtggtcgtcc gggttgtcaa tccctttgag gactagaatc aaatggttgt taagcaaggt 1500
gccaaaaacc gacctgatcc catacagcgg agacgcccga gaagcccggg acgcagaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcgcgaa gccctaccac ctctacaggc 1620
agcacaggaa gatgttcagg tcgaaatcga cgtggaacag cttgaggaca gagcgggcgc 1680
aggaataata gagactccga gaggagctat caaagttact gcccaaccaa cagaccacgt 1740
cgtgggagag tacctggtac tctccccgca gaccgtacta cgtagccaga agctcagtct 1800
gattcacgct ttggcggagc aagtgaagac gtgcacgcac aacggacgag cagggaggta 1860
tgcggtcgaa gcgtacgacg gccgagtcct agtgccctca ggctatgcaa tctcgcctga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtat aacgaaagag agttcgtaaa 1980
cagaaagcta caccatattg cgatgcacgg accagccctg aacaccgacg aagagtcgta 2040
tgagctggtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg atcagagaag 2100
atgctgtaag aaggaagaag ccgcaggact ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatatg aagggctaaa aatccgccct gcctgcccat acaaaattgc 2220
agtcatagga gtcttcggag taccgggatc tggcaagtca gctattatca agaacctagt 2280
taccaggcag gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcaccaccga 2340
cgtgatgaga cagagaggtc tagagatatc tgcacgtacg gttgactcgc tgctcttgaa 2400
tggatgcaac agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgctactt gctttgatcg ccttggtgag accaaggcag aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactata atcacaacat 2580
ctgcacccaa gtgtaccaca aaagtatctc caggcggtgt acactgcctg tgaccgccat 2640
tgtgtcatcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acaagccgat 2700
tgtagtggac actacaggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga tacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt agacaaaaag ttaatgaaaa 2880
cccgctctat gcatcaacgt cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacacttt ccggcgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaagcaacta ttaaggagtg ggaggtggag catgcatcaa taatggcggg 3060
catctgcagt caccaaatga ccttcgatac attccaaaat aaagccaacg tttgttgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
tcagataatt caagccttca aagaagacaa agcatactca cctgaagtag ccctgaatga 3240
aatatgtacg cgcatgtatg gggtggatct agacagcggg ctattttcta aaccgttggt 3300
gtctgtgtat tacgcggata accactggga taataggcct ggagggaaaa tgttcggatt 3360
taaccccgag gcagcatcca ttctagaaag aaagtatcca ttcacaaaag ggaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gactttaacc ctaccaccaa 3480
catcataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacggc caccacgtgc tcctggtcag 3600
tggctataac cttgcactgc ctactaagag agtcacttgg gtagcgccgt taggtgtccg 3660
tggagcggac tacacataca acctagagtt gggtctgcca gcaacgcttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtcga 3780
ccacgcaatg aaactgcaaa tgctcggggg tgactcattg agactgctca aaccgggcgg 3840
ctctctattg atcagagcat atggttacgc agatagaacc agtgaacgag ttagatcaaa 3900
gggccgaata acccctgaat agtaacaaaa tatgaaaatc aataaaaatc ataaaataga 3960
aaaaccataa acagaagtag ttcaaagggc tataaaaccc ctgaatagta acaaaacata 4020
aaattaataa aaatcaaatg aataccataa ttggcaaacg gaagagatgt aggtacttaa 4080
gcttcctaaa agcagccgaa ctcactttga gaagtaggca tagcataccg aactcttcca 4140
cgattctccg aacccacagg gacgtaggag atgttatttt gtttttaata tttcaaaaaa 4200
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 4235
<210> 37
<211> 4032
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 37
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctcgacaaac tgggcagatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgacg gaaggtagac gaggcaagtt gtctattatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctctac ccggaaagcc gcaagctact 840
taagagctgg cacctgccat cggtgttcca tttaaagggc aaactcagct tcacatgccg 900
ctgtgataca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacag ggtatgcggt aacccaccac gcagacggat tcctgatgtg 1020
caagactacc gacacggttg acggcgaaag agtgtcattc tcggtgtgca catacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
tacgaacacc atgaaaaatt atctgcttcc cgtggtcgcc caagccttca gtaagtgggc 1260
aaaggagtgc cggaaagaca tggaagatga aaaactcctg ggggtcagag aaagaacact 1320
gacctgctgc tgtctatggg cattcaagaa gcagaaaaca cacacggtct acaagagacc 1380
tgatacccag tcaattcaga aggttcaggc cgagtttgac agctttgtgg taccgagtct 1440
gtggtcgtcc gggttgtcaa tccctttgag gactagaatc aaatggttgt taagcaaggt 1500
gccaaaaacc gacctgatcc catacagcgg agacgcccga gaagcccggg acgcagaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcgcgaa gccctaccac ctctacaggc 1620
agcacaggaa gatgttcagg tcgaaatcga cgtggaacag cttgaggaca gagcgggcgc 1680
aggaataata gagactccga gaggagctat caaagttact gcccaaccaa cagaccacgt 1740
cgtgggagag tacctggtac tctccccgca gaccgtacta cgtagccaga agctcagtct 1800
gattcacgct ttggcggagc aagtgaagac gtgcacgcac aacggacgag cagggaggta 1860
tgcggtcgaa gcgtacgacg gccgagtcct agtgccctca ggctatgcaa tctcgcctga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtat aacgaaagag agttcgtaaa 1980
cagaaagcta caccatattg cgatgcacgg accagccctg aacaccgacg aagagtcgta 2040
tgagctggtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg atcagagaag 2100
atgctgtaag aaggaagaag ccgcaggact ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatatg aagggctaaa aatccgccct gcctgcccat acaaaattgc 2220
agtcatagga gtcttcggag taccgggatc tggcaagtca gctattatca agaacctagt 2280
taccaggcag gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcaccaccga 2340
cgtgatgaga cagagaggtc tagagatatc tgcacgtacg gttgactcgc tgctcttgaa 2400
tggatgcaac agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgctactt gctttgatcg ccttggtgag accaaggcag aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactata atcacaacat 2580
ctgcacccaa gtgtaccaca aaagtatctc caggcggtgt acactgcctg tgaccgccat 2640
tgtgtcatcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acaagccgat 2700
tgtagtggac actacaggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga tacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt agacaaaaag ttaatgaaaa 2880
cccgctctat gcatcaacgt cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacacttt ccggcgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaagcaacta ttaaggagtg ggaggtggag catgcatcaa taatggcggg 3060
catctgcagt caccaaatga ccttcgatac attccaaaat aaagccaacg tttgttgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
tcagataatt caagccttca aagaagacaa agcatactca cctgaagtag ccctgaatga 3240
aatatgtacg cgcatgtatg gggtggatct agacagcggg ctattttcta aaccgttggt 3300
gtctgtgtat tacgcggata accactggga taataggcct ggagggaaaa tgttcggatt 3360
taaccccgag gcagcatcca ttctagaaag aaagtatcca ttcacaaaag ggaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gactttaacc ctaccaccaa 3480
catcataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacggc caccacgtgc tcctggtcag 3600
tggctataac cttgcactgc ctactaagag agtcacttgg gtagcgccgt taggtgtccg 3660
tggagcggac tacacataca acctagagtt gggtctgcca gcaacgcttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtcga 3780
ccacgcaatg aaactgcaaa tgctcggggg tgactcattg agactgctca aaccgggcgg 3840
ctctctattg gcaaacggaa gagatgtagg tacttaagct tcctaaaagc agccgaactc 3900
actttgagaa gtaggcatag cataccgaac tcttccacga ttctccgaac ccacagggac 3960
gtaggagatg ttattttgtt tttaatattt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4020
aaaaaaaaaa aa 4032
<210> 38
<211> 8753
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 38
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctcgacaaac tgggcagatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgacg gaaggtagac gaggcaagtt gtctattatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctctac ccggaaagcc gcaagctact 840
taagagctgg cacctgccat cggtgttcca tttaaagggc aaactcagct tcacatgccg 900
ctgtgataca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacag ggtatgcggt aacccaccac gcagacggat tcctgatgtg 1020
caagactacc gacacggttg acggcgaaag agtgtcattc tcggtgtgca catacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
tacgaacacc atgaaaaatt atctgcttcc cgtggtcgcc caagccttca gtaagtgggc 1260
aaaggagtgc cggaaagaca tggaagatga aaaactcctg ggggtcagag aaagaacact 1320
gacctgctgc tgtctatggg cattcaagaa gcagaaaaca cacacggtct acaagagacc 1380
tgatacccag tcaattcaga aggttcaggc cgagtttgac agctttgtgg taccgagtct 1440
gtggtcgtcc gggttgtcaa tccctttgag gactagaatc aaatggttgt taagcaaggt 1500
gccaaaaacc gacctgatcc catacagcgg agacgcccga gaagcccggg acgcagaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcgcgaa gccctaccac ctctacaggc 1620
agcacaggaa gatgttcagg tcgaaatcga cgtggaacag cttgaggaca gagcgggcgc 1680
aggaataata gagactccga gaggagctat caaagttact gcccaaccaa cagaccacgt 1740
cgtgggagag tacctggtac tctccccgca gaccgtacta cgtagccaga agctcagtct 1800
gattcacgct ttggcggagc aagtgaagac gtgcacgcac aacggacgag cagggaggta 1860
tgcggtcgaa gcgtacgacg gccgagtcct agtgccctca ggctatgcaa tctcgcctga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtat aacgaaagag agttcgtaaa 1980
cagaaagcta caccatattg cgatgcacgg accagccctg aacaccgacg aagagtcgta 2040
tgagctggtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg atcagagaag 2100
atgctgtaag aaggaagaag ccgcaggact ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatatg aagggctaaa aatccgccct gcctgcccat acaaaattgc 2220
agtcatagga gtcttcggag taccgggatc tggcaagtca gctattatca agaacctagt 2280
taccaggcag gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcaccaccga 2340
cgtgatgaga cagagaggtc tagagatatc tgcacgtacg gttgactcgc tgctcttgaa 2400
tggatgcaac agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgctactt gctttgatcg ccttggtgag accaaggcag aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactata atcacaacat 2580
ctgcacccaa gtgtaccaca aaagtatctc caggcggtgt acactgcctg tgaccgccat 2640
tgtgtcatcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acaagccgat 2700
tgtagtggac actacaggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga tacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt agacaaaaag ttaatgaaaa 2880
cccgctctat gcatcaacgt cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacacttt ccggcgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaagcaacta ttaaggagtg ggaggtggag catgcatcaa taatggcggg 3060
catctgcagt caccaaatga ccttcgatac attccaaaat aaagccaacg tttgttgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
tcagataatt caagccttca aagaagacaa agcatactca cctgaagtag ccctgaatga 3240
aatatgtacg cgcatgtatg gggtggatct agacagcggg ctattttcta aaccgttggt 3300
gtctgtgtat tacgcggata accactggga taataggcct ggagggaaaa tgttcggatt 3360
taaccccgag gcagcatcca ttctagaaag aaagtatcca ttcacaaaag ggaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gactttaacc ctaccaccaa 3480
catcataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacggc caccacgtgc tcctggtcag 3600
tggctataac cttgcactgc ctactaagag agtcacttgg gtagcgccgt taggtgtccg 3660
tggagcggac tacacataca acctagagtt gggtctgcca gcaacgcttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtcga 3780
ccacgcaatg aaactgcaaa tgctcggggg tgactcattg agactgctca aaccgggcgg 3840
ctctctattg atcagagcat atggttacgc agatagaacc agtgaacgag tcatctgcgt 3900
attgggacgc aagtttagat cgtctagagc gttgaaacca ccatgtgtca ccagcaacac 3960
tgagatgttt ttcctattca gcaactttga caatggcaga aggaatttca caactcatgt 4020
catgaacaat caactgaatg cagccttcgt aggacaggtc acccgagcag gatgtgcacc 4080
gtcgtaccgg gtaaaacgca tggacatcgc gaagaacgat gaagagtgcg tagtcaacgc 4140
cgctaaccct cgcgggttac cgggtgacgg tgtttgcaag gcagtataca aaaaatggcc 4200
ggagtccttt aagaacagtg caacaccagt gggaaccgca aaaacagtta tgtgcggtac 4260
gtatccagta atccacgctg ttggaccaaa cttctctaat tattcggagt ctgaagggga 4320
ccgggaattg gcagctgcct atcgagaagt cgcaaaggaa gtaactaggc tgggagtaaa 4380
tagtgtagct atacctctcc tctccacagg tgtatactca ggagggaaag acaggctgac 4440
ccagtcactg aaccacctct ttacagccat ggactcgacg gatgcagacg tggtcatcta 4500
ctgccgcgac aaagaatggg agaagaaaat atctgaggcc atacagatgc ggacccaagt 4560
agagctgctg gatgagcaca tctccataga ctgcgatatt gttcgcgtgc accctgacag 4620
cagcttggca ggcagaaaag gatacagcac cacggaaggc gcactgtact catatctaga 4680
agggacccgt tttcatcaga cggctgtgga tatggcggag atacatacta tgtggccaaa 4740
gcaaacagag gccaatgagc aagtctgcct atatgccctg ggggaaagta ttgaatcgat 4800
caggcagaaa tgcccggtgg atgatgcaga cgcatcatct ccccccaaaa ctgtcccgtg 4860
cctttgccgt tacgctatga ctccagaacg cgtcacccgg cttcgcatga accacgtcac 4920
aagcataatt gtgtgttctt cgtttcccct cccaaagtac aaaatagaag gagtgcaaaa 4980
agtcaaatgc tctaaggtaa tgctatttga ccacaacgtg ccatcgcgcg taagtccaag 5040
ggaatataga tcttcccagg agtctgcaca ggaggcgagt acaatcacgt cactgacgca 5100
tagtcaattc gacctaagcg ttgatggcga gatactgccc gtcccgtcag acctggatgc 5160
tgacgcccca gccctagaac cagcactaga cgacggggcg acacacacgc tgccatccac 5220
aaccggaaac cttgcggccg tgtctgattg ggtaatgagc accgtacctg tcgcgccgcc 5280
cagaagaagg cgagggagaa acctgactgt gacatgtgac gagagagaag ggaatataac 5340
acccatggct agcgtccgat tctttagggc agagctgtgt ccggtcgtac aagaaacagc 5400
ggagacgcgt gacacagcaa tgtctcttca ggcaccaccg agtaccgcca cggaaccgaa 5460
tcatccgccg atctccttcg gagcatcaag cgagacgttc cccattacat ttggggactt 5520
caacgaagga gaaatcgaaa gcttgtcttc tgagctacta actttcggag acttcttacc 5580
aggagaagtg gatgacttga cagacagcga ctggtccacg tgctcagaca cggacgacga 5640
gttatgacta gacagggcag gtgggtatat attctcgtcg gacaccggtc caggtcattt 5700
acaacagaag tcagtacgcc agtcagtgct gccggtgaac accctggagg aagtccacga 5760
ggagaagtgt tacccaccta agctggatga agcaaaggag caactattac ttaagaaact 5820
ccaggagagt gcatccatgg ccaacagaag caggtatcag tcgcgcaaag tagaaaacat 5880
gaaagcagca atcatccaga gactaaagag aggctgtaga ctatacttaa tgtcagagac 5940
cccaaaagtc cctacttacc ggactacata tccggcgcct gtgtactcgc ctccgatcaa 6000
cgtccgattg tccaatcccg agtccgcagt ggcagcatgc aatgagttct tagctagaaa 6060
ctatccaact gtctcatcat accaaattac cgacgagtat gatgcatatc tagacatggt 6120
ggacgggtcg gagagttgcc tggaccgagc gacattcaat ccgtcaaaac tcaggagcta 6180
cccgaaacag cacgcttacc acgcgccctc catcagaagc gctgtaccgt ccccattcca 6240
gaacacacta cagaatgtac tggcagcagc cacgaaaaga aactgcaacg tcacacagat 6300
gagggaatta cccactttgg actcagcagt attcaacgtg gagtgtttca aaaaattcgc 6360
atgcaaccaa gaatactggg aagaatttgc tgccagccct attaggataa caactgagaa 6420
tttagcaacc tatgttacta aactaaaagg gccaaaagca gcagcgctat tcgcaaaaac 6480
ccataatcta ctgccactac aggaagtacc aatggatagg ttcacagtag atatgaaaag 6540
ggacgtaaag gtgactcctg gtacaaagca tacagaggaa agacctaagg tgcaggttat 6600
acaggcggct gaacccttgg cgacagcata cctatgtggg attcacagag agctggttag 6660
gaggctgaac gccgtcctcc tacccaatgt acatacacta tttgacatgt ctgccgagga 6720
tttcgatgcc atcatagccg cacactttaa gccaggagac actgttttgg aaacggacat 6780
agcctccttt gataagagcc aagatgattc acttgcgctt actgctttga tgctgttaga 6840
ggatttaggg gtggatcact ccctgctgga cttgatagag gctgctttcg gagagatttc 6900
cagctgtcac ctaccgacag gtacgcgctt caagttcggc gccatgatga aatcaggtat 6960
gttcctaact ctgttcgtca acacattgtt aaacatcacc atcgccagcc gagtgctgga 7020
agatcgtctg acaaaatccg cgtgcgcggc cttcatcggc gacgacaaca taatacatgg 7080
agtcgtctcc gatgaattga tggcagccag atgtgccact tggatgaaca tggaagtgaa 7140
gatcatagat gcagttgtat ccttgaaagc cccttacttt tgtggagggt ttatactgca 7200
cgatactgtg acaggaacag cttgcagagt ggcagacccg ctaaaaaggc tttttaaact 7260
gggcaaaccg ctagcggcag gtgacgaaca agatgaagat agaagacgag cgctggctga 7320
cgaagtgatc agatggcaac gaacagggct aattgatgag ctggagaaag cggtatactc 7380
taggtacgaa gtgcagggta tatcagttgt ggtaatgtcc atggccacct ttgcaagctc 7440
cagatccaac ttcgagaagc tcagaggacc cgtcataact ttgtacggcg gtcctaaata 7500
ggtacgcact acagctacct attttgcaga agccgacagc aagtatctaa acactaatca 7560
gctacaatgg agttcatccc aacccaaact ttttacaata ggaggtacca gcctcgaccc 7620
tggactccgc gccctactat ccaagtcatc aggcccagac cgcgccctca gaggcaagct 7680
gggcaacttg cccagctgat ctcagcagtt aataaactga caatgcgcgc ggtaccccaa 7740
cagaagccac gcaggaatcg gaagaataag aagcaaaagc aaaaacaaca ggcgccacaa 7800
aacaacacaa atcaaaagaa gcagccacct aaaaagaaac cggctcaaaa gaaaaagaag 7860
ccgggccgca gagagaggat gtgcatgaaa atcgaaaatg attgtatttt cgaagtcaag 7920
cacgaaggta aggtaacagg ttacgcgtgc ctggtggggg acaaagtaat gaaaccagca 7980
cacgtaaagg ggaccatcga taacgcggac ctggccaaac tggcctttaa gcggtcatct 8040
aagtatgacc ttgaatgcgc gcagataccc gtgcacatga agtccgacgc ttcgaagttc 8100
acccatgaga aaccggaggg gtactacaac tggcaccacg gagcagtaca gtactcagga 8160
ggccggttca ccatccctac aggtgctggc aaaccagggg acagcggcag accgatcttc 8220
gacaacaagg gacgcgtggt ggccatagtc ttaggaggag ctaatgaagg agcccgtaca 8280
gccctctcgg tggtgacctg gaataaagac attgtcacta aaatcacccc cgagggggcc 8340
gaagagtgga gtcttgccat cccagttatg tgcctgttgg caaacaccac gttcccctgc 8400
tcccagcccc cttgcacgcc ctgctgctac gaaaaggaac cggaggaaac cctacgcatg 8460
cttgaggaca acgtcatgag acctgggtac tatcgtagtt caaagggcta taaaacccct 8520
gaatagtaac aaaacataaa attaataaaa atcaaatgaa taccataatt ggcaaacgga 8580
agagatgtag gtacttaagc ttcctaaaag cagccgaact cactttgaga agtaggcata 8640
gcataccgaa ctcttccacg attctccgaa cccacaggga cgtaggagat gttattttgt 8700
ttttaatatt tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 8753
<210> 39
<211> 3912
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 39
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctcgacaaac tgggcagatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgacg gaaggtagac gaggcaagtt gtctattatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctctac ccggaaagcc gcaagctact 840
taagagctgg cacctgccat cggtgttcca tttaaagggc aaactcagct tcacatgccg 900
ctgtgataca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacag ggtatgcggt aacccaccac gcagacggat tcctgatgtg 1020
caagactacc gacacggttg acggcgaaag agtgtcattc tcggtgtgca catacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
tacgaacacc atgaaaaatt atctgcttcc cgtggtcgcc caagccttca gtaagtgggc 1260
aaaggagtgc cggaaagaca tggaagatga aaaactcctg ggggtcagag aaagaacact 1320
gacctgctgc tgtctatggg cattcaagaa gcagaaaaca cacacggtct acaagagacc 1380
tgatacccag tcaattcaga aggttcaggc cgagtttgac agctttgtgg taccgagtct 1440
gtggtcgtcc gggttgtcaa tccctttgag gactagaatc aaatggttgt taagcaaggt 1500
gccaaaaacc gacctgatcc catacagcgg agacgcccga gaagcccggg acgcagaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcgcgaa gccctaccac ctctacaggc 1620
agcacaggaa gatgttcagg tcgaaatcga cgtggaacag cttgaggaca gagcgggcgc 1680
aggaataata gagactccga gaggagctat caaagttact gcccaaccaa cagaccacgt 1740
cgtgggagag tacctggtac tctccccgca gaccgtacta cgtagccaga agctcagtct 1800
gattcacgct ttggcggagc aagtgaagac gtgcacgcac aacggacgag cagggaggta 1860
tgcggtcgaa gcgtacgacg gccgagtcct agtgccctca ggctatgcaa tctcgcctga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtat aacgaaagag agttcgtaaa 1980
cagaaagcta caccatattg cgatgcacgg accagccctg aacaccgacg aagagtcgta 2040
tgagctggtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg atcagagaag 2100
atgctgtaag aaggaagaag ccgcaggact ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatatg aagggctaaa aatccgccct gcctgcccat acaaaattgc 2220
agtcatagga gtcttcggag taccgggatc tggcaagtca gctattatca agaacctagt 2280
taccaggcag gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcaccaccga 2340
cgtgatgaga cagagaggtc tagagatatc tgcacgtacg gttgactcgc tgctcttgaa 2400
tggatgcaac agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgctactt gctttgatcg ccttggtgag accaaggcag aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactata atcacaacat 2580
ctgcacccaa gtgtaccaca aaagtatctc caggcggtgt acactgcctg tgaccgccat 2640
tgtgtcatcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acaagccgat 2700
tgtagtggac actacaggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga tacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt agacaaaaag ttaatgaaaa 2880
cccgctctat gcatcaacgt cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacacttt ccggcgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaagcaacta ttaaggagtg ggaggtggag catgcatcaa taatggcggg 3060
catctgcagt caccaaatga ccttcgatac attccaaaat aaagccaacg tttgttgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
tcagataatt caagccttca aagaagacaa agcatactca cctgaagtag ccctgaatga 3240
aatatgtacg cgcatgtatg gggtggatct agacagcggg ctattttcta aaccgttggt 3300
gtctgtgtat tacgcggata accactggga taataggcct ggagggaaaa tgttcggatt 3360
taaccccgag gcagcatcca ttctagaaag aaagtatcca ttcacaaaag ggaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gactttaacc ctaccaccaa 3480
catcataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gatcaaaggg ccgaataacc cctgaatagt 3600
aacaaaatat gaaaatcaat aaaaatcata aaatagaaaa accataaaca gaagtagttc 3660
aaagggctat aaaacccctg aatagtaaca aaacataaaa ttaataaaaa tcaaatgaat 3720
accataattg gcaaacggaa gagatgtagg tacttaagct tcctaaaagc agccgaactc 3780
actttgagaa gtaggcatag cataccgaac tcttccacga ttctccgaac ccacagggac 3840
gtaggagatg ttattttgtt tttaatattt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3900
aaaaaaaaaa aa 3912
<210> 40
<211> 9541
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 40
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacgagctt ggtccctatc ctcgaaacag cggggataaa actaaatgat 480
aggcagtggt cccagataat tcaagctttc aaagaagaca aagcatactc acccgaagta 540
gccctgaatg aaatatgcac gcgcatgtat ggggtggatc tagacagcgg gctattctct 600
aaaccgttgg tatctgtgta ttacgcggat aaccactggg ataataggcc gggaggaaag 660
atgttcggat tcaaccctga ggcagcgtcc attctagaaa gaaagtaccc gtttacaaaa 720
ggaaagtgga acatcaacaa gcagatctgc gtgactacca ggaggataga agacttcaac 780
cctaccacca acattatacc ggccaacagg agactaccac actcattagt ggccgaacac 840
cgcccagtaa aaggggaaag aatggaatgg ctggttaaca agataaacgg acatcatgtg 900
ctcctggtta gcggctataa ccttgcactg cctactaaga gagtcacctg ggtagcgcca 960
ctaggtgtcc gcggagcgga ctatacatac aacctagagc tgggtctacc ggcaacactt 1020
ggtaggtatg acctagtggt cataaacatc cacacacctt ttcgcataca ccattaccaa 1080
cagtgcgtag atcacgcaat gaaactgcaa atgctaggag gtgactcact gagactgctc 1140
aaaccgggtg gctctctatt gatcagagca tacggttacg cagatagaac cagtgaacga 1200
gtaatctgcg tactgggacg taagtttaga tcgtccagag cattgaaacc accatgtatc 1260
accagtaata ctgagatgtt cttcctattt agcagttttg acaatggcag aaggaatttt 1320
acaacgcatg ttatgaacaa tcaactgaac gcagcctttg taggacaggc cacccgagca 1380
ggatgtgcac catcgtaccg ggtaaagcgc atggacatcg cgaagaacga tgaagagtgc 1440
gtggtcaacg ccgccaaccc tcgcgggtta ccgggtgacg gtgtttgcaa ggcagtatat 1500
aaaaaatggc cggagtcctt taaaaatagt gcaacaccag taggaaccgc aaaaacagtt 1560
atgtgcggta catatccagt aatccatgcc gtaggaccaa acttctcaaa ttacacggag 1620
tccgaagggg accgggaatt ggcggctgcc tatcgagaag tcgcaaagga agtaactaga 1680
ctgggagtaa atagcgtagc tatacctctc ctctccacag gtgtatactc aggagggaaa 1740
gacaggctaa cccagtcact gaaccacctc tttacagcca tggactcgac ggatgcagac 1800
gtggtcatct actgccgaga caaggaatgg gagaagaaaa tatctgaggc catacagatg 1860
cggacccaag tggagctgct ggatgagcac atctccatag actgcgatgt cattcgcgtg 1920
caccctgaca gtagtttggc aggtagaaaa ggatacagca ccacggaagg cgcactgtat 1980
tcatatctag aagggacacg ttttcaccag acggcagtgg atgtggcaga gatacatact 2040
atgtggccaa agcaaataga ggccaatgag caagtctgcc tatatgccct gggggaaagt 2100
attgagtcaa tcaggcagaa atgcccggtg gatgatgcag atgcatcatc tcccccgaaa 2160
accgtcccgt gcctttgccg ttatgccatg actcctgaac gcgtcacccg acttcgcatg 2220
aaccatgtca caaatataat tgtgtgttct tcatttcccc ttccaaagta caagatagaa 2280
ggagtgcaaa aagtcaaatg ctccaaggta atgttatttg atcacaatgt gccatcgcgc 2340
gtaagtccaa gggaatacag atcttcccag gagtctgtac gggaagtgag tatgacaacg 2400
tcattgacgc atagtcagtt tgatctaagc gccgatggcg agacactgcc cgtcccgtca 2460
gacctggatg ctgacgcccc agccctagaa ccggccctag acgacggggc gatacatacg 2520
accggaaacc ttgcggccgt gtctgactgg gtaatgagca ccgtacccgt cgcgccgcct 2580
agaagaagga gagggagaaa cctgaccgtg atatgtgacg agagagaagg gaatataaca 2640
cccatggcta gcgtccgatt ctttagagca gagcagtgtc cgaccgtaca agaaacagcg 2700
gagacgcgtg acacagctat ttcctttcgg gcaccgccaa gtatcaccgt ggaactgagc 2760
catccaccga tctccttcgg agcaccaagc gagacgttcc ccatcacatt tggggacttc 2820
aacgatggag aaatcgaaag cttgtcttct gagctactaa ctttcggaga cttcctaccc 2880
ggtgaagtgg atgatttgac agatagcgac tggtccacgt gctcagacac ggacgacgag 2940
ttatgactag acagggcagg tgggtatata ttctcgtcgg acaccggtcc aggccattta 3000
caacagaagt cggtacgcca gtcagtgctg ccggtaaaca ccctggagga agttcacgag 3060
gagaagtgtt acccacctaa gctggatgaa ttaaaggagc aactactact taagaaactc 3120
caggagagtg cgtccacggc caatagaagc aggtatcaat cacgcaaagt ggaaaatatg 3180
aaagcaacaa tcatccagag actaaagaga ggctgtaaac tgtatttaat ggcagagacc 3240
ccgaaagtcc cgacttatcg gaccgtatac ccggcgcctg tgtactcgcc tccgatcaac 3300
gtccgattgt ccaatcccga gtccgcagtg gcagcatgta atgagttctt agctagaaac 3360
tacccaactg tttcatcata ccaaatcacc gatgagtatg atgcatatct agacatggtg 3420
gacgggtcgg agagttgctt ggaccgagcg acattcaatc cgtcaaaact taggagctac 3480
ccgaaacaac atgcttatca cgcgccctct atcagaagcg ctgtaccttc cccattccag 3540
aacacactac agaatgtact ggcagcagcc acgaaaagga actgcaacgt cacacagatg 3600
agggaattac ccactttgga ctcagcagta ttcaacgtgg agtgttttaa aaaattcgca 3660
tgcaaccgag aatactggga agaatttgct gccagcccta tcaggataac gactgagaat 3720
ctaacaacct atgtcactaa attaaagggg ccaaaagcag cagcgttgct tgcaagaacc 3780
cataatctgc tgccgctgca ggatgtacca atggataggt tcacagtaga tatgaaaagg 3840
gacgtgaagg taactcctgg cacaaagcat acagaggaaa ggcctaaggt gcaggttata 3900
caggcggctg aacccttggc aacagcgtac ctatgtggaa ttcacagaga attggttagg 3960
agattgaacg ccgtcctcct acccaacgtg catacactat ttgacatgtc tgccgaggac 4020
ttcgatgcca ttatagccgc acactttaag ccaggagacg ccgttttaga aacggacata 4080
gcctcctttg ataagagcca ggatgattca cttgcgctta ccgccttaat gctgttagaa 4140
gatttgggag tggatcactc cttgttggac ctgatagagg ctgcttttgg agagatttcc 4200
agctgtcacc tgccgacagg tacgcgcttc aagttcggcg ctatgatgaa atccggtatg 4260
ttcctaactc tgttcgtcaa cacattgtta aatatcacca tcgctagccg ggtgttggaa 4320
gatcgtctga caaaatctgc atgcgcggcc ttcatcggcg acgacaacat aatacatggt 4380
gtcgtctccg atgaattgat ggcagccaga tgcgctactt ggatgaacat ggaagtgaag 4440
atcatagatg cagttgtatc ccagaaagct ccctactttt gtggagggtt tatactgcat 4500
gatactgtga caggaacagc ttgcagggtg gcggacccgc taaaaaggtt atttaaactg 4560
ggcaaaccgt tagcggcagg tgacgaacaa gacgaagaca gaaggcgggc gctggctgat 4620
gaagtaatca gatggcaacg aacagggcta atagatgagc tggagaaagc ggtgtactct 4680
aggtacgaag tgcagggtat atcagttgct gtaatgtcca tggccacctt tgcaagctcc 4740
agatccaact tcgagaagct cagaggaccc gtcataacct tgtacggcgg tcctaaatag 4800
gtacgcacta cagctaccta ttttgcaaaa gccgacagca ggtacctaaa taccaatcag 4860
ccataatgga gtttatccca acccaaactt tctacaatag gaggtaccag cctcgacctt 4920
ggactccgcg ccctactatc caagtcatca gacccagacc gcgtccgcaa aggaaggccg 4980
ggcaacttgc ccagctgatc tcagcagtta ataaactgac aatgcgcgtg gtacctcaac 5040
agaagccgcg caagaatcgg aagaataaga agcaaaagca aaagcagcag gcgccacgaa 5100
acaatacgaa tcaaaagaag cagcccccca aaaagaaacc ggttcaaaag aaaaagaagc 5160
cgggccgcag agagagaatg tgcatgaaaa tcgaaaatga ttgcatcttc gaagtcaagc 5220
atgaaggtaa ggtaacaggt tacgcgtgct tggtagggga caaagtaatg aagccagcac 5280
acgtaaaggg gaccatcgat aacgcggacc tggccaaatt ggccttcaag cggtcatcta 5340
agtacgacct tgaatgcgcg cagatacccg tgcacatgaa gtccgacgct tcgaagttca 5400
cccatgagaa accggagggg tactacaact ggcaccacgg agcagtacag tactcaggag 5460
gccgattcac catccctaca ggtgcgggca aaccagggga tagtggtaga ccgatcttcg 5520
acaacaaggg gcgcgtggtg gccatagttt taggaggagc taatgaagga gcccgtacag 5580
ccctctcggt ggtgacctgg aacaaagaca tcgtcacgaa aatcacccct gagggggccg 5640
aagagtggag tctggccatt ccagttatgt gcctgctggc aaataccacg ttcccctgct 5700
cccggccccc ttgcacaccc tgctgctacg aaaaagagcc ggagaaaacc ttgcgcatgc 5760
ttgaagacaa tgtcatgagc cccgggtact atcagctgct acaagcatcc ttaacatgtt 5820
ctccccgacg ccagcggcgc agtattaagg accacttcaa tgtctataaa gccacaagac 5880
cgtacctagc tcactgtccc gactgtggag aagggcactc gtgccatagt cccgtagcgc 5940
tagaacgcat cagaaacgaa gcgacagacg ggacgttgaa aatccaggtt tccttgcaaa 6000
tcggaataaa gacggatgat agccatgatt ggaccaagct gcgttatatg gacaatcaca 6060
tgccagcaga cgcagagcgg gccgggctat ttgtaagaac gtcagcaccg tgcacgatta 6120
ctggaacaat gggacacttc attctggccc gatgtccgaa aggagaaact ctgacggtgg 6180
ggttcactga cggtaggaag atcagtcact catgtacgca cccatttcac catgaccctc 6240
ctgtgatagg ccgggaaaaa ttccattccc gaccgcagca cggtagggaa ctaccttgca 6300
gcacgtacgc gcagagcacc gctgcaactg ccgaggagat agaggtacac atgcccccag 6360
acaccccaga tcgcacatta atgtcacaac agtccggcaa tgtaaagatc acagtcaata 6420
gtcagacggt gcggtacaag tgcaattgtg gtgactcaag tgaaggatta accactacag 6480
ataaagtgat taataactgc aaggtcgatc aatgccatgc cgcggtcacc aatcacaaaa 6540
aatggcagta taattcccct ctggtcccgc gtaatgctga attcggggac cggaaaggaa 6600
aagttcacat tccatttcct ctggcaaatg tgacatgcag ggtgcctaaa gcaagaaacc 6660
ccaccgtgac gtacggaaaa aaccaagtca tcatgttgct gtatcctgac cacccaacgc 6720
tcctgtccta caggaatatg ggagaagaac caaactatca agaagagtgg gtgacgcata 6780
agaaggagat caggttaacc gtgccgactg aggggctcga ggtcacgtgg ggtaacaatg 6840
agccgtacaa gtattggccg cagttatcca caaacggtac agcccacggc cacccgcatg 6900
agataattct gtattattat gagctgtacc caactatgac tgcggtagtt ttgtcagtgg 6960
cctcgttcat actcctgtcg atggtgggtg tggcagtggg gatgtgcatg tgtgcacgac 7020
gcagatgcat tacaccgtac gaactgacac caggagctac cgtccctttc ctgcttagcc 7080
taatatgctg cattagaaca gctaaagcgg ccacatacca ggaggccgcg gtatacctgt 7140
ggaacgagca gcagccttta ttttggatgc aagcccttat tccgctggca gccctgattg 7200
tcctatgtaa ctgtctgaga ctcttaccat gctgttgtaa aatgttgact tttttagccg 7260
tactgagcgt cggtgcccac actgtgagcg cgtacgaaca cgtaacagtg atcccgaaca 7320
cggtgggagt accgtataag actctagtca acagaccggg ctacagcccc atggtattgg 7380
agatggagct tctgtctgtc accttggaac caacgctatc gcttgattac atcacgtgcg 7440
agtataaaac cgttatcccg tctccgtacg tgaaatgctg cggtacagca gagtgtaagg 7500
acaagagcct acctgattac agctgtaagg tcttcaccgg cgtctaccca ttcatgtggg 7560
gcggcgccta ctgcttctgc gacaccgaaa atacgcaatt gagcgaagca catgtggaga 7620
agtccgaatc atgcaaaaca gaatttgcat cagcatacag ggctcatacc gcatccgcat 7680
cagctaagct ccgcgtcctt taccaaggaa ataatatcac tgtggctgct tatgcaaacg 7740
gcgaccatgc cgtcacagtt aaggacgcta aattcatagt ggggccaatg tcttcagcct 7800
ggacaccttt cgacaataaa atcgtggtgt acaaaggcga cgtctacaac atggactacc 7860
cgcccttcgg cgcaggaaga ccaggacaat ttggcgacat ccaaagtcgc acgcctgaga 7920
gcgaagacgt ctatgctaat acacaactgg tactgcagag accgtccgcg ggtacggtgc 7980
acgtgccgta ctctcaggca ccatctggct tcaagtattg gctaaaagaa cgaggggcgt 8040
cgctgcagca cacagcacca tttggctgtc aaatagcaac aaacccggta agagcgatga 8100
actgcgccgt agggaacatg cctatctcca tcgacatacc ggacgcggcc tttaccaggg 8160
tcgtcgacgc gccatcttta acggacatgt cgtgtgaggt atcagcctgc acccattcct 8220
cagactttgg gggcgtagcc atcattaaat atgcagccag taagaaaggc aagtgtgcag 8280
tgcactcgat gactaacgcc gtcactattc gggaagctga aatagaagta gaagggaact 8340
ctcagttgca aatctctttt tcgacggccc tagccagcgc cgaatttcgc gtacaagtct 8400
gttctacaca agtacactgt gcagccgagt gccatccacc gaaagaccat atagtcaatt 8460
acccggcgtc acacaccacc ctcggggtcc aagacatttc cgctacggcg atgtcatggg 8520
tgcagaagat cacgggaggt gtgggactgg ttgtcgctgt tgcagcactg atcctaatcg 8580
tggtgctatg cgtgtcgttt agcaggcact aacttgacaa ctaggtatga aggcatacgc 8640
gtccctaaag agacacaccg catatagcta ggaatcaaca gataagtata gatctaaggg 8700
ctgaacaacc cctgaataac aaaatataaa aatcaacaaa aatcataaaa tagaaaacta 8760
gaaatagaag taggtaagaa ggtatatgtg tcccctaaga gacacaccat atatagctaa 8820
gaatcaatag ataagcatag atcaaagggc tgaacaaccc ctgaataata acaaaatata 8880
aaaaccaata aaaatcataa aatagaaaat caacaaaaat cataaaatag aaaactagaa 8940
atagaagtag gtaagaaggt atatgtgtcc cctaagagac acaccatata tagctaagaa 9000
tcaatagata agcatagatc aaagggctga acaacccctg aataataaca aaatataaaa 9060
accaataaaa atcataaaat agaaaaccac aaatagaagt agttcaaagg gctataaaac 9120
ccctgaatag taacaaaata taaaactaat aaaaatcaaa cgaataccat aattggcaat 9180
cggaagagat gtaggtactt aagcttctta aaagcagccg aactcgcttt gagatgtagg 9240
cgtagcacac cgaactcttc cataattctc cgaacccaca gggacgtagg agatgttcaa 9300
agtgactata aaaccctgaa cagtaataaa atataaaatt aataatgagt accataattg 9360
gcaaatggaa gagacgtagg tactaagctt cttaaaagca gccgaactca ctttgagatg 9420
taggcatagc ataccgaact cttccacaat tctccgtacc catagggacg taggagatgt 9480
tattttgttt ttaatatttc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 9540
a 9541
<210> 41
<211> 10014
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 41
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctaacccact ctatgcatca acatcagagc acgtcaacgt actcctaacg cgtacggaag 720
gtaaactggt atggaagaca ctctctggtg acccgtggat aaagacgctg cagaacccac 780
cgaaaggaaa cttcaaggca actattaagg agtgggaggt ggagcacgca tcgataatgg 840
cgggcatctg cagtcaccaa gtgacctttg acacgttcca aaacaaagcc aacgtttgct 900
gggctaagag cttggtccct atcctcgaaa cagcggggat aaaactaaat gataggcagt 960
ggtcccagat aattcaagct ttcaaagaag acaaagcata ctcacccgaa gtagccctga 1020
atgaaatatg cacgcgcatg tatggggtgg atctagacag cgggctattc tctaaaccgt 1080
tggtatctgt gtattacgcg gataaccact gggataatag gccgggagga aagatgttcg 1140
gattcaaccc tgaggcagcg tccattctag aaagaaagta cccgtttaca aaaggaaagt 1200
ggaacatcaa caagcagatc tgcgtgacta ccaggaggat agaagacttc aaccctacca 1260
ccaacattat accggccaac aggagactac cacactcatt agtggccgaa caccgcccag 1320
taaaagggga aagaatggaa tggctggtta acaagataaa cggacatcat gtgctcctgg 1380
ttagcggcta taaccttgca ctgcctacta agagagtcac ctgggtagcg ccactaggtg 1440
tccgcggagc ggactataca tacaacctag agctgggtct accggcaaca cttggtaggt 1500
atgacctagt ggtcataaac atccacacac cttttcgcat acaccattac caacagtgcg 1560
tagatcacgc aatgaaactg caaatgctag gaggtgactc actgagactg ctcaaaccgg 1620
gtggctctct attgatcaga gcatacggtt acgcagatag aaccagtgaa cgagtaatct 1680
gcgtactggg acgtaagttt agatcgtcca gagcattgaa accaccatgt atcaccagta 1740
atactgagat gttcttccta tttagcagtt ttgacaatgg cagaaggaat tttacaacgc 1800
atgttatgaa caatcaactg aacgcagcct ttgtaggaca ggccacccga gcaggatgtg 1860
caccatcgta ccgggtaaag cgcatggaca tcgcgaagaa cgatgaagag tgcgtggtca 1920
acgccgccaa ccctcgcggg ttaccgggtg acggtgtttg caaggcagta tataaaaaat 1980
ggccggagtc ctttaaaaat agtgcaacac cagtaggaac cgcaaaaaca gttatgtgcg 2040
gtacatatcc agtaatccat gccgtaggac caaacttctc aaattacacg gagtccgaag 2100
gggaccggga attggcggct gcctatcgag aagtcgcaaa ggaagtaact agactgggag 2160
taaatagcgt agctatacct ctcctctcca caggtgtata ctcaggaggg aaagacaggc 2220
taacccagtc actgaaccac ctctttacag ccatggactc gacggatgca gacgtggtca 2280
tctactgccg agacaaggaa tgggagaaga aaatatctga ggccatacag atgcggaccc 2340
aagtggagct gctggatgag cacatctcca tagactgcga tgtcattcgc gtgcaccctg 2400
acagtagttt ggcaggtaga aaaggataca gcaccacgga aggcgcactg tattcatatc 2460
tagaagggac acgttttcac cagacggcag tggatgtggc agagatacat actatgtggc 2520
caaagcaaat agaggccaat gagcaagtct gcctatatgc cctgggggaa agtattgagt 2580
caatcaggca gaaatgcccg gtggatgatg cagatgcatc atctcccccg aaaaccgtcc 2640
cgtgcctttg ccgttatgcc atgactcctg aacgcgtcac ccgacttcgc atgaaccatg 2700
tcacaaatat aattgtgtgt tcttcatttc cccttccaaa gtacaagata gaaggagtgc 2760
aaaaagtcaa atgctccaag gtaatgttat ttgatcacaa tgtgccatcg cgcgtaagtc 2820
caagggaata cagatcttcc caggagtctg tacgggaagt gagtatgaca acgtcattga 2880
cgcatagtca gtttgatcta agcgccgatg gcgagacact gcccgtcccg tcagacctgg 2940
atgctgacgc cccagcccta gaaccggccc tagacgacgg ggcgatacat acgaccggaa 3000
accttgcggc cgtgtctgac tgggtaatga gcaccgtacc cgtcgcgccg cctagaagaa 3060
ggagagggag aaacctgacc gtgatatgtg acgagagaga agggaatata acacccatgg 3120
ctagcgtccg attctttaga gcagagcagt gtccgaccgt acaagaaaca gcggagacgc 3180
gtgacacagc tatttccttt cgggcaccgc caagtatcac cgtggaactg agccatccac 3240
cgatctcctt cggagcacca agcgagacgt tccccatcac atttggggac ttcaacgatg 3300
gagaaatcga aagcttgtct tctgagctac taactttcgg agacttccta cccggtgaag 3360
tggatgattt gacagatagc gactggtcca cgtgctcaga cacggacgac gagttatgac 3420
tagacagggc aggtgggtat atattctcgt cggacaccgg tccaggccat ttacaacaga 3480
agtcggtacg ccagtcagtg ctgccggtaa acaccctgga ggaagttcac gaggagaagt 3540
gttacccacc taagctggat gaattaaagg agcaactact acttaagaaa ctccaggaga 3600
gtgcgtccac ggccaataga agcaggtatc aatcacgcaa agtggaaaat atgaaagcaa 3660
caatcatcca gagactaaag agaggctgta aactgtattt aatggcagag accccgaaag 3720
tcccgactta tcggaccgta tacccggcgc ctgtgtactc gcctccgatc aacgtccgat 3780
tgtccaatcc cgagtccgca gtggcagcat gtaatgagtt cttagctaga aactacccaa 3840
ctgtttcatc ataccaaatc accgatgagt atgatgcata tctagacatg gtggacgggt 3900
cggagagttg cttggaccga gcgacattca atccgtcaaa acttaggagc tacccgaaac 3960
aacatgctta tcacgcgccc tctatcagaa gcgctgtacc ttccccattc cagaacacac 4020
tacagaatgt actggcagca gccacgaaaa ggaactgcaa cgtcacacag atgagggaat 4080
tacccacttt ggactcagca gtattcaacg tggagtgttt taaaaaattc gcatgcaacc 4140
gagaatactg ggaagaattt gctgccagcc ctatcaggat aacgactgag aatctaacaa 4200
cctatgtcac taaattaaag gggccaaaag cagcagcgtt gcttgcaaga acccataatc 4260
tgctgccgct gcaggatgta ccaatggata ggttcacagt agatatgaaa agggacgtga 4320
aggtaactcc tggcacaaag catacagagg aaaggcctaa ggtgcaggtt atacaggcgg 4380
ctgaaccctt ggcaacagcg tacctatgtg gaattcacag agaattggtt aggagattga 4440
acgccgtcct cctacccaac gtgcatacac tatttgacat gtctgccgag gacttcgatg 4500
ccattatagc cgcacacttt aagccaggag acgccgtttt agaaacggac atagcctcct 4560
ttgataagag ccaggatgat tcacttgcgc ttaccgcctt aatgctgtta gaagatttgg 4620
gagtggatca ctccttgttg gacctgatag aggctgcttt tggagagatt tccagctgtc 4680
acctgccgac aggtacgcgc ttcaagttcg gcgctatgat gaaatccggt atgttcctaa 4740
ctctgttcgt caacacattg ttaaatatca ccatcgctag ccgggtgttg gaagatcgtc 4800
tgacaaaatc tgcatgcgcg gccttcatcg gcgacgacaa cataatacat ggtgtcgtct 4860
ccgatgaatt gatggcagcc agatgcgcta cttggatgaa catggaagtg aagatcatag 4920
atgcagttgt atcccagaaa gctccctact tttgtggagg gtttatactg catgatactg 4980
tgacaggaac agcttgcagg gtggcggacc cgctaaaaag gttatttaaa ctgggcaaac 5040
cgttagcggc aggtgacgaa caagacgaag acagaaggcg ggcgctggct gatgaagtaa 5100
tcagatggca acgaacaggg ctaatagatg agctggagaa agcggtgtac tctaggtacg 5160
aagtgcaggg tatatcagtt gctgtaatgt ccatggccac ctttgcaagc tccagatcca 5220
acttcgagaa gctcagagga cccgtcataa ccttgtacgg cggtcctaaa taggtacgca 5280
ctacagctac ctattttgca aaagccgaca gcaggtacct aaataccaat cagccataat 5340
ggagtttatc ccaacccaaa ctttctacaa taggaggtac cagcctcgac cttggactcc 5400
gcgccctact atccaagtca tcagacccag accgcgtccg caaaggaagg ccgggcaact 5460
tgcccagctg atctcagcag ttaataaact gacaatgcgc gtggtacctc aacagaagcc 5520
gcgcaagaat cggaagaata agaagcaaaa gcaaaagcag caggcgccac gaaacaatac 5580
gaatcaaaag aagcagcccc ccaaaaagaa accggttcaa aagaaaaaga agccgggccg 5640
cagagagaga atgtgcatga aaatcgaaaa tgattgcatc ttcgaagtca agcatgaagg 5700
taaggtaaca ggttacgcgt gcttggtagg ggacaaagta atgaagccag cacacgtaaa 5760
ggggaccatc gataacgcgg acctggccaa attggccttc aagcggtcat ctaagtacga 5820
ccttgaatgc gcgcagatac ccgtgcacat gaagtccgac gcttcgaagt tcacccatga 5880
gaaaccggag gggtactaca actggcacca cggagcagta cagtactcag gaggccgatt 5940
caccatccct acaggtgcgg gcaaaccagg ggatagtggt agaccgatct tcgacaacaa 6000
ggggcgcgtg gtggccatag ttttaggagg agctaatgaa ggagcccgta cagccctctc 6060
ggtggtgacc tggaacaaag acatcgtcac gaaaatcacc cctgaggggg ccgaagagtg 6120
gagtctggcc attccagtta tgtgcctgct ggcaaatacc acgttcccct gctcccggcc 6180
cccttgcaca ccctgctgct acgaaaaaga gccggagaaa accttgcgca tgcttgaaga 6240
caatgtcatg agccccgggt actatcagct gctacaagca tccttaacat gttctccccg 6300
acgccagcgg cgcagtatta aggaccactt caatgtctat aaagccacaa gaccgtacct 6360
agctcactgt cccgactgtg gagaagggca ctcgtgccat agtcccgtag cgctagaacg 6420
catcagaaac gaagcgacag acgggacgtt gaaaatccag gtttccttgc aaatcggaat 6480
aaagacggat gatagccatg attggaccaa gctgcgttat atggacaatc acatgccagc 6540
agacgcagag cgggccgggc tatttgtaag aacgtcagca ccgtgcacga ttactggaac 6600
aatgggacac ttcattctgg cccgatgtcc gaaaggagaa actctgacgg tggggttcac 6660
tgacggtagg aagatcagtc actcatgtac gcacccattt caccatgacc ctcctgtgat 6720
aggccgggaa aaattccatt cccgaccgca gcacggtagg gaactacctt gcagcacgta 6780
cgcgcagagc accgctgcaa ctgccgagga gatagaggta cacatgcccc cagacacccc 6840
agatcgcaca ttaatgtcac aacagtccgg caatgtaaag atcacagtca atagtcagac 6900
ggtgcggtac aagtgcaatt gtggtgactc aagtgaagga ttaaccacta cagataaagt 6960
gattaataac tgcaaggtcg atcaatgcca tgccgcggtc accaatcaca aaaaatggca 7020
gtataattcc cctctggtcc cgcgtaatgc tgaattcggg gaccggaaag gaaaagttca 7080
cattccattt cctctggcaa atgtgacatg cagggtgcct aaagcaagaa accccaccgt 7140
gacgtacgga aaaaaccaag tcatcatgtt gctgtatcct gaccacccaa cgctcctgtc 7200
ctacaggaat atgggagaag aaccaaacta tcaagaagag tgggtgacgc ataagaagga 7260
gatcaggtta accgtgccga ctgaggggct cgaggtcacg tggggtaaca atgagccgta 7320
caagtattgg ccgcagttat ccacaaacgg tacagcccac ggccacccgc atgagataat 7380
tctgtattat tatgagctgt acccaactat gactgcggta gttttgtcag tggcctcgtt 7440
catactcctg tcgatggtgg gtgtggcagt ggggatgtgc atgtgtgcac gacgcagatg 7500
cattacaccg tacgaactga caccaggagc taccgtccct ttcctgctta gcctaatatg 7560
ctgcattaga acagctaaag cggccacata ccaggaggcc gcggtatacc tgtggaacga 7620
gcagcagcct ttattttgga tgcaagccct tattccgctg gcagccctga ttgtcctatg 7680
taactgtctg agactcttac catgctgttg taaaatgttg acttttttag ccgtactgag 7740
cgtcggtgcc cacactgtga gcgcgtacga acacgtaaca gtgatcccga acacggtggg 7800
agtaccgtat aagactctag tcaacagacc gggctacagc cccatggtat tggagatgga 7860
gcttctgtct gtcaccttgg aaccaacgct atcgcttgat tacatcacgt gcgagtataa 7920
aaccgttatc ccgtctccgt acgtgaaatg ctgcggtaca gcagagtgta aggacaagag 7980
cctacctgat tacagctgta aggtcttcac cggcgtctac ccattcatgt ggggcggcgc 8040
ctactgcttc tgcgacaccg aaaatacgca attgagcgaa gcacatgtgg agaagtccga 8100
atcatgcaaa acagaatttg catcagcata cagggctcat accgcatccg catcagctaa 8160
gctccgcgtc ctttaccaag gaaataatat cactgtggct gcttatgcaa acggcgacca 8220
tgccgtcaca gttaaggacg ctaaattcat agtggggcca atgtcttcag cctggacacc 8280
tttcgacaat aaaatcgtgg tgtacaaagg cgacgtctac aacatggact acccgccctt 8340
cggcgcagga agaccaggac aatttggcga catccaaagt cgcacgcctg agagcgaaga 8400
cgtctatgct aatacacaac tggtactgca gagaccgtcc gcgggtacgg tgcacgtgcc 8460
gtactctcag gcaccatctg gcttcaagta ttggctaaaa gaacgagggg cgtcgctgca 8520
gcacacagca ccatttggct gtcaaatagc aacaaacccg gtaagagcga tgaactgcgc 8580
cgtagggaac atgcctatct ccatcgacat accggacgcg gcctttacca gggtcgtcga 8640
cgcgccatct ttaacggaca tgtcgtgtga ggtatcagcc tgcacccatt cctcagactt 8700
tgggggcgta gccatcatta aatatgcagc cagtaagaaa ggcaagtgtg cagtgcactc 8760
gatgactaac gccgtcacta ttcgggaagc tgaaatagaa gtagaaggga actctcagtt 8820
gcaaatctct ttttcgacgg ccctagccag cgccgaattt cgcgtacaag tctgttctac 8880
acaagtacac tgtgcagccg agtgccatcc accgaaagac catatagtca attacccggc 8940
gtcacacacc accctcgggg tccaagacat ttccgctacg gcgatgtcat gggtgcagaa 9000
gatcacggga ggtgtgggac tggttgtcgc tgttgcagca ctgatcctaa tcgtggtgct 9060
atgcgtgtcg tttagcaggc actaacttga caactaggta tgaaggcata cgcgtcccta 9120
aagagacaca ccgcatatag ctaggaatca acagataagt atagatctaa gggctgaaca 9180
acccctgaat aacaaaatat aaaaatcaac aaaaatcata aaatagaaaa ctagaaatag 9240
aagtaggtaa gaaggtatat gtgtccccta agagacacac catatatagc taagaatcaa 9300
tagataagca tagatcaaag ggctgaacaa cccctgaata ataacaaaat ataaaaacca 9360
ataaaaatca taaaatagaa aatcaacaaa aatcataaaa tagaaaacta gaaatagaag 9420
taggtaagaa ggtatatgtg tcccctaaga gacacaccat atatagctaa gaatcaatag 9480
ataagcatag atcaaagggc tgaacaaccc ctgaataata acaaaatata aaaaccaata 9540
aaaatcataa aatagaaaac cacaaataga agtagttcaa agggctataa aacccctgaa 9600
tagtaacaaa atataaaact aataaaaatc aaacgaatac cataattggc aatcggaaga 9660
gatgtaggta cttaagcttc ttaaaagcag ccgaactcgc tttgagatgt aggcgtagca 9720
caccgaactc ttccataatt ctccgaaccc acagggacgt aggagatgtt caaagtgact 9780
ataaaaccct gaacagtaat aaaatataaa attaataatg agtaccataa ttggcaaatg 9840
gaagagacgt aggtactaag cttcttaaaa gcagccgaac tcactttgag atgtaggcat 9900
agcataccga actcttccac aattctccgt acccataggg acgtaggaga tgttattttg 9960
tttttaatat ttcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 10014
<210> 42
<211> 4595
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 42
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taagatcaaa 3900
gggctgaaca acccctgaat aataacaaaa tataaaaacc aataaaaatc ataaaataga 3960
aaatcaacaa aaatcataaa atagaaaact agaaatagaa gtaggtaaga aggtatatgt 4020
gtcccctaag agacacacca tatatagcta agaatcaata gataagcata gatcaaaggg 4080
ctgaacaacc cctgaataat aacaaaatat aaaaaccaat aaaaatcata aaatagaaaa 4140
ccacaaatag aagtagttca aagggctata aaacccctga atagtaacaa aatataaaac 4200
taataaaaat caaacgaata ccataattgg caatcggaag agatgtaggt acttaagctt 4260
cttaaaagca gccgaactcg ctttgagatg taggcgtagc acaccgaact cttccataat 4320
tctccgaacc cacagggacg taggagatgt tcaaagtgac tataaaaccc tgaacagtaa 4380
taaaatataa aattaataat gagtaccata attggcaaat ggaagagacg taggtactaa 4440
gcttcttaaa agcagccgaa ctcactttga gatgtaggca tagcataccg aactcttcca 4500
caattctccg tacccatagg gacgtaggag atgttatttt gtttttaata tttcaaaaaa 4560
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 4595
<210> 43
<211> 4418
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 43
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taagatcaaa 3900
gggctgaaca acccctgaat aataacaaaa tataaaaacc aataaaaatc ataaaataga 3960
aaaccacaaa tagaagtagt tcaaagggct ataaaacccc tgaatagtaa caaaatataa 4020
aactaataaa aatcaaacga ataccataat tggcaatcgg aagagatgta ggtacttaag 4080
cttcttaaaa gcagccgaac tcgctttgag atgtaggcgt agcacaccga actcttccat 4140
aattctccga acccacaggg acgtaggaga tgttcaaagt gactataaaa ccctgaacag 4200
taataaaata taaaattaat aatgagtacc ataattggca aatggaagag acgtaggtac 4260
taagcttctt aaaagcagcc gaactcactt tgagatgtag gcatagcata ccgaactctt 4320
ccacaattct ccgtacccat agggacgtag gagatgttat tttgttttta atatttcaaa 4380
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 4418
<210> 44
<211> 10549
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 44
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagaaa attcgccccg cttgtccata taaaattgca 540
gtcataggag tcttcggggt accaggatct ggtaagtcag ccattatcaa gaacctagtt 600
accaggcaag acctggtgac tagcggaaag aaagaaaact gccaagaaat cagcaccgac 660
gtgatgagac agagaggtct agaaatatct gcacgtacgg ttgattcgct gctcttgaat 720
ggatgcaata gaccagtcga cgtgttgtac gtagacgagg cgtttgcgtg ccactctgga 780
acgttacttg ccttgatcgc cttggtgaga ccaagactga aagttgtact ttgtggtgac 840
ccgaagcagt gcggcttctt caatatgatg cagatgaaag tcaactacaa tcataacatc 900
tgcactcaag tgtaccacaa aagtatttcc aggcggtgta cactgcctgt gactgccatt 960
gtgtcgtcgt tgcattacga aggcaaaatg cgcactacga atgagtacaa catgccgatt 1020
gtagtggaca ctacgggctc aacaaaacct gaccctggag acctcgtgtt aacgtgcttc 1080
agagggtggg ttaaacaact gcaaattgac tatcgtggac acgaggtcat gacagcagcc 1140
gcatcccaag ggttaaccag aaaaggagtt tacgcagtta ggcaaaaagt taacgaaaac 1200
ccactctatg catcaacatc agagcacgtc aacgtactcc taacgcgtac ggaaggtaaa 1260
ctggtatgga agacactctc tggtgacccg tggataaaga cgctgcagaa cccaccgaaa 1320
ggaaacttca aggcaactat taaggagtgg gaggtggagc acgcatcgat aatggcgggc 1380
atctgcagtc accaagtgac ctttgacacg ttccaaaaca aagccaacgt ttgctgggct 1440
aagagcttgg tccctatcct cgaaacagcg gggataaaac taaatgatag gcagtggtcc 1500
cagataattc aagctttcaa agaagacaaa gcatactcac ccgaagtagc cctgaatgaa 1560
atatgcacgc gcatgtatgg ggtggatcta gacagcgggc tattctctaa accgttggta 1620
tctgtgtatt acgcggataa ccactgggat aataggccgg gaggaaagat gttcggattc 1680
aaccctgagg cagcgtccat tctagaaaga aagtacccgt ttacaaaagg aaagtggaac 1740
atcaacaagc agatctgcgt gactaccagg aggatagaag acttcaaccc taccaccaac 1800
attataccgg ccaacaggag actaccacac tcattagtgg ccgaacaccg cccagtaaaa 1860
ggggaaagaa tggaatggct ggttaacaag ataaacggac atcatgtgct cctggttagc 1920
ggctataacc ttgcactgcc tactaagaga gtcacctggg tagcgccact aggtgtccgc 1980
ggagcggact atacatacaa cctagagctg ggtctaccgg caacacttgg taggtatgac 2040
ctagtggtca taaacatcca cacacctttt cgcatacacc attaccaaca gtgcgtagat 2100
cacgcaatga aactgcaaat gctaggaggt gactcactga gactgctcaa accgggtggc 2160
tctctattga tcagagcata cggttacgca gatagaacca gtgaacgagt aatctgcgta 2220
ctgggacgta agtttagatc gtccagagca ttgaaaccac catgtatcac cagtaatact 2280
gagatgttct tcctatttag cagttttgac aatggcagaa ggaattttac aacgcatgtt 2340
atgaacaatc aactgaacgc agcctttgta ggacaggcca cccgagcagg atgtgcacca 2400
tcgtaccggg taaagcgcat ggacatcgcg aagaacgatg aagagtgcgt ggtcaacgcc 2460
gccaaccctc gcgggttacc gggtgacggt gtttgcaagg cagtatataa aaaatggccg 2520
gagtccttta aaaatagtgc aacaccagta ggaaccgcaa aaacagttat gtgcggtaca 2580
tatccagtaa tccatgccgt aggaccaaac ttctcaaatt acacggagtc cgaaggggac 2640
cgggaattgg cggctgccta tcgagaagtc gcaaaggaag taactagact gggagtaaat 2700
agcgtagcta tacctctcct ctccacaggt gtatactcag gagggaaaga caggctaacc 2760
cagtcactga accacctctt tacagccatg gactcgacgg atgcagacgt ggtcatctac 2820
tgccgagaca aggaatggga gaagaaaata tctgaggcca tacagatgcg gacccaagtg 2880
gagctgctgg atgagcacat ctccatagac tgcgatgtca ttcgcgtgca ccctgacagt 2940
agtttggcag gtagaaaagg atacagcacc acggaaggcg cactgtattc atatctagaa 3000
gggacacgtt ttcaccagac ggcagtggat gtggcagaga tacatactat gtggccaaag 3060
caaatagagg ccaatgagca agtctgccta tatgccctgg gggaaagtat tgagtcaatc 3120
aggcagaaat gcccggtgga tgatgcagat gcatcatctc ccccgaaaac cgtcccgtgc 3180
ctttgccgtt atgccatgac tcctgaacgc gtcacccgac ttcgcatgaa ccatgtcaca 3240
aatataattg tgtgttcttc atttcccctt ccaaagtaca agatagaagg agtgcaaaaa 3300
gtcaaatgct ccaaggtaat gttatttgat cacaatgtgc catcgcgcgt aagtccaagg 3360
gaatacagat cttcccagga gtctgtacgg gaagtgagta tgacaacgtc attgacgcat 3420
agtcagtttg atctaagcgc cgatggcgag acactgcccg tcccgtcaga cctggatgct 3480
gacgccccag ccctagaacc ggccctagac gacggggcga tacatacgac cggaaacctt 3540
gcggccgtgt ctgactgggt aatgagcacc gtacccgtcg cgccgcctag aagaaggaga 3600
gggagaaacc tgaccgtgat atgtgacgag agagaaggga atataacacc catggctagc 3660
gtccgattct ttagagcaga gcagtgtccg accgtacaag aaacagcgga gacgcgtgac 3720
acagctattt cctttcgggc accgccaagt atcaccgtgg aactgagcca tccaccgatc 3780
tccttcggag caccaagcga gacgttcccc atcacatttg gggacttcaa cgatggagaa 3840
atcgaaagct tgtcttctga gctactaact ttcggagact tcctacccgg tgaagtggat 3900
gatttgacag atagcgactg gtccacgtgc tcagacacgg acgacgagtt atgactagac 3960
agggcaggtg ggtatatatt ctcgtcggac accggtccag gccatttaca acagaagtcg 4020
gtacgccagt cagtgctgcc ggtaaacacc ctggaggaag ttcacgagga gaagtgttac 4080
ccacctaagc tggatgaatt aaaggagcaa ctactactta agaaactcca ggagagtgcg 4140
tccacggcca atagaagcag gtatcaatca cgcaaagtgg aaaatatgaa agcaacaatc 4200
atccagagac taaagagagg ctgtaaactg tatttaatgg cagagacccc gaaagtcccg 4260
acttatcgga ccgtataccc ggcgcctgtg tactcgcctc cgatcaacgt ccgattgtcc 4320
aatcccgagt ccgcagtggc agcatgtaat gagttcttag ctagaaacta cccaactgtt 4380
tcatcatacc aaatcaccga tgagtatgat gcatatctag acatggtgga cgggtcggag 4440
agttgcttgg accgagcgac attcaatccg tcaaaactta ggagctaccc gaaacaacat 4500
gcttatcacg cgccctctat cagaagcgct gtaccttccc cattccagaa cacactacag 4560
aatgtactgg cagcagccac gaaaaggaac tgcaacgtca cacagatgag ggaattaccc 4620
actttggact cagcagtatt caacgtggag tgttttaaaa aattcgcatg caaccgagaa 4680
tactgggaag aatttgctgc cagccctatc aggataacga ctgagaatct aacaacctat 4740
gtcactaaat taaaggggcc aaaagcagca gcgttgcttg caagaaccca taatctgctg 4800
ccgctgcagg atgtaccaat ggataggttc acagtagata tgaaaaggga cgtgaaggta 4860
actcctggca caaagcatac agaggaaagg cctaaggtgc aggttataca ggcggctgaa 4920
cccttggcaa cagcgtacct atgtggaatt cacagagaat tggttaggag attgaacgcc 4980
gtcctcctac ccaacgtgca tacactattt gacatgtctg ccgaggactt cgatgccatt 5040
atagccgcac actttaagcc aggagacgcc gttttagaaa cggacatagc ctcctttgat 5100
aagagccagg atgattcact tgcgcttacc gccttaatgc tgttagaaga tttgggagtg 5160
gatcactcct tgttggacct gatagaggct gcttttggag agatttccag ctgtcacctg 5220
ccgacaggta cgcgcttcaa gttcggcgct atgatgaaat ccggtatgtt cctaactctg 5280
ttcgtcaaca cattgttaaa tatcaccatc gctagccggg tgttggaaga tcgtctgaca 5340
aaatctgcat gcgcggcctt catcggcgac gacaacataa tacatggtgt cgtctccgat 5400
gaattgatgg cagccagatg cgctacttgg atgaacatgg aagtgaagat catagatgca 5460
gttgtatccc agaaagctcc ctacttttgt ggagggttta tactgcatga tactgtgaca 5520
ggaacagctt gcagggtggc ggacccgcta aaaaggttat ttaaactggg caaaccgtta 5580
gcggcaggtg acgaacaaga cgaagacaga aggcgggcgc tggctgatga agtaatcaga 5640
tggcaacgaa cagggctaat agatgagctg gagaaagcgg tgtactctag gtacgaagtg 5700
cagggtatat cagttgctgt aatgtccatg gccacctttg caagctccag atccaacttc 5760
gagaagctca gaggacccgt cataaccttg tacggcggtc ctaaataggt acgcactaca 5820
gctacctatt ttgcaaaagc cgacagcagg tacctaaata ccaatcagcc ataatggagt 5880
ttatcccaac ccaaactttc tacaatagga ggtaccagcc tcgaccttgg actccgcgcc 5940
ctactatcca agtcatcaga cccagaccgc gtccgcaaag gaaggccggg caacttgccc 6000
agctgatctc agcagttaat aaactgacaa tgcgcgtggt acctcaacag aagccgcgca 6060
agaatcggaa gaataagaag caaaagcaaa agcagcaggc gccacgaaac aatacgaatc 6120
aaaagaagca gccccccaaa aagaaaccgg ttcaaaagaa aaagaagccg ggccgcagag 6180
agagaatgtg catgaaaatc gaaaatgatt gcatcttcga agtcaagcat gaaggtaagg 6240
taacaggtta cgcgtgcttg gtaggggaca aagtaatgaa gccagcacac gtaaagggga 6300
ccatcgataa cgcggacctg gccaaattgg ccttcaagcg gtcatctaag tacgaccttg 6360
aatgcgcgca gatacccgtg cacatgaagt ccgacgcttc gaagttcacc catgagaaac 6420
cggaggggta ctacaactgg caccacggag cagtacagta ctcaggaggc cgattcacca 6480
tccctacagg tgcgggcaaa ccaggggata gtggtagacc gatcttcgac aacaaggggc 6540
gcgtggtggc catagtttta ggaggagcta atgaaggagc ccgtacagcc ctctcggtgg 6600
tgacctggaa caaagacatc gtcacgaaaa tcacccctga gggggccgaa gagtggagtc 6660
tggccattcc agttatgtgc ctgctggcaa ataccacgtt cccctgctcc cggccccctt 6720
gcacaccctg ctgctacgaa aaagagccgg agaaaacctt gcgcatgctt gaagacaatg 6780
tcatgagccc cgggtactat cagctgctac aagcatcctt aacatgttct ccccgacgcc 6840
agcggcgcag tattaaggac cacttcaatg tctataaagc cacaagaccg tacctagctc 6900
actgtcccga ctgtggagaa gggcactcgt gccatagtcc cgtagcgcta gaacgcatca 6960
gaaacgaagc gacagacggg acgttgaaaa tccaggtttc cttgcaaatc ggaataaaga 7020
cggatgatag ccatgattgg accaagctgc gttatatgga caatcacatg ccagcagacg 7080
cagagcgggc cgggctattt gtaagaacgt cagcaccgtg cacgattact ggaacaatgg 7140
gacacttcat tctggcccga tgtccgaaag gagaaactct gacggtgggg ttcactgacg 7200
gtaggaagat cagtcactca tgtacgcacc catttcacca tgaccctcct gtgataggcc 7260
gggaaaaatt ccattcccga ccgcagcacg gtagggaact accttgcagc acgtacgcgc 7320
agagcaccgc tgcaactgcc gaggagatag aggtacacat gcccccagac accccagatc 7380
gcacattaat gtcacaacag tccggcaatg taaagatcac agtcaatagt cagacggtgc 7440
ggtacaagtg caattgtggt gactcaagtg aaggattaac cactacagat aaagtgatta 7500
ataactgcaa ggtcgatcaa tgccatgccg cggtcaccaa tcacaaaaaa tggcagtata 7560
attcccctct ggtcccgcgt aatgctgaat tcggggaccg gaaaggaaaa gttcacattc 7620
catttcctct ggcaaatgtg acatgcaggg tgcctaaagc aagaaacccc accgtgacgt 7680
acggaaaaaa ccaagtcatc atgttgctgt atcctgacca cccaacgctc ctgtcctaca 7740
ggaatatggg agaagaacca aactatcaag aagagtgggt gacgcataag aaggagatca 7800
ggttaaccgt gccgactgag gggctcgagg tcacgtgggg taacaatgag ccgtacaagt 7860
attggccgca gttatccaca aacggtacag cccacggcca cccgcatgag ataattctgt 7920
attattatga gctgtaccca actatgactg cggtagtttt gtcagtggcc tcgttcatac 7980
tcctgtcgat ggtgggtgtg gcagtgggga tgtgcatgtg tgcacgacgc agatgcatta 8040
caccgtacga actgacacca ggagctaccg tccctttcct gcttagccta atatgctgca 8100
ttagaacagc taaagcggcc acataccagg aggccgcggt atacctgtgg aacgagcagc 8160
agcctttatt ttggatgcaa gcccttattc cgctggcagc cctgattgtc ctatgtaact 8220
gtctgagact cttaccatgc tgttgtaaaa tgttgacttt tttagccgta ctgagcgtcg 8280
gtgcccacac tgtgagcgcg tacgaacacg taacagtgat cccgaacacg gtgggagtac 8340
cgtataagac tctagtcaac agaccgggct acagccccat ggtattggag atggagcttc 8400
tgtctgtcac cttggaacca acgctatcgc ttgattacat cacgtgcgag tataaaaccg 8460
ttatcccgtc tccgtacgtg aaatgctgcg gtacagcaga gtgtaaggac aagagcctac 8520
ctgattacag ctgtaaggtc ttcaccggcg tctacccatt catgtggggc ggcgcctact 8580
gcttctgcga caccgaaaat acgcaattga gcgaagcaca tgtggagaag tccgaatcat 8640
gcaaaacaga atttgcatca gcatacaggg ctcataccgc atccgcatca gctaagctcc 8700
gcgtccttta ccaaggaaat aatatcactg tggctgctta tgcaaacggc gaccatgccg 8760
tcacagttaa ggacgctaaa ttcatagtgg ggccaatgtc ttcagcctgg acacctttcg 8820
acaataaaat cgtggtgtac aaaggcgacg tctacaacat ggactacccg cccttcggcg 8880
caggaagacc aggacaattt ggcgacatcc aaagtcgcac gcctgagagc gaagacgtct 8940
atgctaatac acaactggta ctgcagagac cgtccgcggg tacggtgcac gtgccgtact 9000
ctcaggcacc atctggcttc aagtattggc taaaagaacg aggggcgtcg ctgcagcaca 9060
cagcaccatt tggctgtcaa atagcaacaa acccggtaag agcgatgaac tgcgccgtag 9120
ggaacatgcc tatctccatc gacataccgg acgcggcctt taccagggtc gtcgacgcgc 9180
catctttaac ggacatgtcg tgtgaggtat cagcctgcac ccattcctca gactttgggg 9240
gcgtagccat cattaaatat gcagccagta agaaaggcaa gtgtgcagtg cactcgatga 9300
ctaacgccgt cactattcgg gaagctgaaa tagaagtaga agggaactct cagttgcaaa 9360
tctctttttc gacggcccta gccagcgccg aatttcgcgt acaagtctgt tctacacaag 9420
tacactgtgc agccgagtgc catccaccga aagaccatat agtcaattac ccggcgtcac 9480
acaccaccct cggggtccaa gacatttccg ctacggcgat gtcatgggtg cagaagatca 9540
cgggaggtgt gggactggtt gtcgctgttg cagcactgat cctaatcgtg gtgctatgcg 9600
tgtcgtttag caggcactaa cttgacaact aggtatgaag gcatacgcgt ccctaaagag 9660
acacaccgca tatagctagg aatcaacaga taagtataga tctaagggct gaacaacccc 9720
tgaataacaa aatataaaaa tcaacaaaaa tcataaaata gaaaactaga aatagaagta 9780
ggtaagaagg tatatgtgtc ccctaagaga cacaccatat atagctaaga atcaatagat 9840
aagcatagat caaagggctg aacaacccct gaataataac aaaatataaa aaccaataaa 9900
aatcataaaa tagaaaatca acaaaaatca taaaatagaa aactagaaat agaagtaggt 9960
aagaaggtat atgtgtcccc taagagacac accatatata gctaagaatc aatagataag 10020
catagatcaa agggctgaac aacccctgaa taataacaaa atataaaaac caataaaaat 10080
cataaaatag aaaaccacaa atagaagtag ttcaaagggc tataaaaccc ctgaatagta 10140
acaaaatata aaactaataa aaatcaaacg aataccataa ttggcaatcg gaagagatgt 10200
aggtacttaa gcttcttaaa agcagccgaa ctcgctttga gatgtaggcg tagcacaccg 10260
aactcttcca taattctccg aacccacagg gacgtaggag atgttcaaag tgactataaa 10320
accctgaaca gtaataaaat ataaaattaa taatgagtac cataattggc aaatggaaga 10380
gacgtaggta ctaagcttct taaaagcagc cgaactcact ttgagatgta ggcatagcat 10440
accgaactct tccacaattc tccgtaccca tagggacgta ggagatgtta ttttgttttt 10500
aatatttcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 10549
<210> 45
<211> 1186
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 45
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccatcaaca aaaatcataa aatagaaaac tagaaataga agtaggtaag 600
aaggtatatg tgtcccctaa gagacacacc atatatagct aagaatcaat agataagcat 660
agatcaaagg gctgaacaac ccctgaataa taacaaaata taaaaaccaa taaaaatcat 720
aaaatagaaa accacaaata gaagtagttc aaagggctat aaaacccctg aatagtaaca 780
aaatataaaa ctaataaaaa tcaaacgaat accataattg gcaatcggaa gagatgtagg 840
tacttaagct tcttaaaagc agccgaactc gctttgagat gtaggcgtag cacaccgaac 900
tcttccataa ttctccgaac ccacagggac gtaggagatg ttcaaagtga ctataaaacc 960
ctgaacagta ataaaatata aaattaataa tgagtaccat aattggcaaa tggaagagac 1020
gtaggtacta agcttcttaa aagcagccga actcactttg agatgtaggc atagcatacc 1080
gaactcttcc acaattctcc gtacccatag ggacgtagga gatgttattt tgtttttaat 1140
atttcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1186
<210> 46
<211> 1106
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 46
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccaatagct aagaatcaat agataagcat agatcaaagg gctgaacaac 600
ccctgaataa taacaaaata taaaaaccaa taaaaatcat aaaatagaaa accacaaata 660
gaagtagttc aaagggctat aaaacccctg aatagtaaca aaatataaaa ctaataaaaa 720
tcaaacgaat accataattg gcaatcggaa gagatgtagg tacttaagct tcttaaaagc 780
agccgaactc gctttgagat gtaggcgtag cacaccgaac tcttccataa ttctccgaac 840
ccacagggac gtaggagatg ttcaaagtga ctataaaacc ctgaacagta ataaaatata 900
aaattaataa tgagtaccat aattggcaaa tggaagagac gtaggtacta agcttcttaa 960
aagcagccga actcactttg agatgtaggc atagcatacc gaactcttcc acaattctcc 1020
gtacccatag ggacgtagga gatgttattt tgtttttaat atttcaaaaa aaaaaaaaaa 1080
aaaaaaaaaa aaaaaaaaaa aaaaaa 1106
<210> 47
<211> 9566
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 47
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatagagca 2700
gtgtccgacc gtacaagaaa cagcggagac gcgtgacaca gctatttcct ttcgggcacc 2760
gccaagtatc accgtggaac tgagccatcc accgatctcc ttcggagcac caagcgagac 2820
gttccccatc acatttgggg acttcaacga tggagaaatc gaaagcttgt cttctgagct 2880
actaactttc ggagacttcc tacccggtga agtggatgat ttgacagata gcgactggtc 2940
cacgtgctca gacacggacg acgagttatg actagacagg gcaggtgggt atatattctc 3000
gtcggacacc ggtccaggcc atttacaaca gaagtcggta cgccagtcag tgctgccggt 3060
aaacaccctg gaggaagttc acgaggagaa gtgttaccca cctaagctgg atgaattaaa 3120
ggagcaacta ctacttaaga aactccagga gagtgcgtcc acggccaata gaagcaggta 3180
tcaatcacgc aaagtggaaa atatgaaagc aacaatcatc cagagactaa agagaggctg 3240
taaactgtat ttaatggcag agaccccgaa agtcccgact tatcggaccg tatacccggc 3300
gcctgtgtac tcgcctccga tcaacgtccg attgtccaat cccgagtccg cagtggcagc 3360
atgtaatgag ttcttagcta gaaactaccc aactgtttca tcataccaaa tcaccgatga 3420
gtatgatgca tatctagaca tggtggacgg gtcggagagt tgcttggacc gagcgacatt 3480
caatccgtca aaacttagga gctacccgaa acaacatgct tatcacgcgc cctctatcag 3540
aagcgctgta ccttccccat tccagaacac actacagaat gtactggcag cagccacgaa 3600
aaggaactgc aacgtcacac agatgaggga attacccact ttggactcag cagtattcaa 3660
cgtggagtgt tttaaaaaat tcgcatgcaa ccgagaatac tgggaagaat ttgctgccag 3720
ccctatcagg ataacgactg agaatctaac aacctatgtc actaaattaa aggggccaaa 3780
agcagcagcg ttgcttgcaa gaacccataa tctgctgccg ctgcaggatg taccaatgga 3840
taggttcaca gtagatatga aaagggacgt gaaggtaact cctggcacaa agcatacaga 3900
ggaaaggcct aaggtgcagg ttatacaggc ggctgaaccc ttggcaacag cgtacctatg 3960
tggaattcac agagaattgg ttaggagatt gaacgccgtc ctcctaccca acgtgcatac 4020
actatttgac atgtctgccg aggacttcga tgccattata gccgcacact ttaagccagg 4080
agacgccgtt ttagaaacgg acatagcctc ctttgataag agccaggatg attcacttgc 4140
gcttaccgcc ttaatgctgt tagaagattt gggagtggat cactccttgt tggacctgat 4200
agaggctgct tttggagaga tttccagctg tcacctgccg acaggtacgc gcttcaagtt 4260
cggcgctatg atgaaatccg gtatgttcct aactctgttc gtcaacacat tgttaaatat 4320
caccatcgct agccgggtgt tggaagatcg tctgacaaaa tctgcatgcg cggccttcat 4380
cggcgacgac aacataatac atggtgtcgt ctccgatgaa ttgatggcag ccagatgcgc 4440
tacttggatg aacatggaag tgaagatcat agatgcagtt gtatcccaga aagctcccta 4500
cttttgtgga gggtttatac tgcatgatac tgtgacagga acagcttgca gggtggcgga 4560
cccgctaaaa aggttattta aactgggcaa accgttagcg gcaggtgacg aacaagacga 4620
agacagaagg cgggcgctgg ctgatgaagt aatcagatgg caacgaacag ggctaataga 4680
tgagctggag aaagcggtgt actctaggta cgaagtgcag ggtatatcag ttgctgtaat 4740
gtccatggcc acctttgcaa gctccagatc caacttcgag aagctcagag gacccgtcat 4800
aaccttgtac ggcggtccta aataggtacg cactacagct acctattttg caaaagccga 4860
cagcaggtac ctaaatacca atcagccata atggagttta tcccaaccca aactttctac 4920
aataggaggt accagcctcg accttggact ccgcgcccta ctatccaagt catcagaccc 4980
agaccgcgtc cgcaaaggaa ggccgggcaa cttgcccagc tgatctcagc agttaataaa 5040
ctgacaatgc gcgtggtacc tcaacagaag ccgcgcaaga atcggaagaa taagaagcaa 5100
aagcaaaagc agcaggcgcc acgaaacaat acgaatcaaa agaagcagcc ccccaaaaag 5160
aaaccggttc aaaagaaaaa gaagccgggc cgcagagaga gaatgtgcat gaaaatcgaa 5220
aatgattgca tcttcgaagt caagcatgaa ggtaaggtaa caggttacgc gtgcttggta 5280
ggggacaaag taatgaagcc agcacacgta aaggggacca tcgataacgc ggacctggcc 5340
aaattggcct tcaagcggtc atctaagtac gaccttgaat gcgcgcagat acccgtgcac 5400
atgaagtccg acgcttcgaa gttcacccat gagaaaccgg aggggtacta caactggcac 5460
cacggagcag tacagtactc aggaggccga ttcaccatcc ctacaggtgc gggcaaacca 5520
ggggatagtg gtagaccgat cttcgacaac aaggggcgcg tggtggccat agttttagga 5580
ggagctaatg aaggagcccg tacagccctc tcggtggtga cctggaacaa agacatcgtc 5640
acgaaaatca cccctgaggg ggccgaagag tggagtctgg ccattccagt tatgtgcctg 5700
ctggcaaata ccacgttccc ctgctcccgg cccccttgca caccctgctg ctacgaaaaa 5760
gagccggaga aaaccttgcg catgcttgaa gacaatgtca tgagccccgg gtactatcag 5820
ctgctacaag catccttaac atgttctccc cgacgccagc ggcgcagtat taaggaccac 5880
ttcaatgtct ataaagccac aagaccgtac ctagctcact gtcccgactg tggagaaggg 5940
cactcgtgcc atagtcccgt agcgctagaa cgcatcagaa acgaagcgac agacgggacg 6000
ttgaaaatcc aggtttcctt gcaaatcgga ataaagacgg atgatagcca tgattggacc 6060
aagctgcgtt atatggacaa tcacatgcca gcagacgcag agcgggccgg gctatttgta 6120
agaacgtcag caccgtgcac gattactgga acaatgggac acttcattct ggcccgatgt 6180
ccgaaaggag aaactctgac ggtggggttc actgacggta ggaagatcag tcactcatgt 6240
acgcacccat ttcaccatga ccctcctgtg ataggccggg aaaaattcca ttcccgaccg 6300
cagcacggta gggaactacc ttgcagcacg tacgcgcaga gcaccgctgc aactgccgag 6360
gagatagagg tacacatgcc cccagacacc ccagatcgca cattaatgtc acaacagtcc 6420
ggcaatgtaa agatcacagt caatagtcag acggtgcggt acaagtgcaa ttgtggtgac 6480
tcaagtgaag gattaaccac tacagataaa gtgattaata actgcaaggt cgatcaatgc 6540
catgccgcgg tcaccaatca caaaaaatgg cagtataatt cccctctggt cccgcgtaat 6600
gctgaattcg gggaccggaa aggaaaagtt cacattccat ttcctctggc aaatgtgaca 6660
tgcagggtgc ctaaagcaag aaaccccacc gtgacgtacg gaaaaaacca agtcatcatg 6720
ttgctgtatc ctgaccaccc aacgctcctg tcctacagga atatgggaga agaaccaaac 6780
tatcaagaag agtgggtgac gcataagaag gagatcaggt taaccgtgcc gactgagggg 6840
ctcgaggtca cgtggggtaa caatgagccg tacaagtatt ggccgcagtt atccacaaac 6900
ggtacagccc acggccaccc gcatgagata attctgtatt attatgagct gtacccaact 6960
atgactgcgg tagttttgtc agtggcctcg ttcatactcc tgtcgatggt gggtgtggca 7020
gtggggatgt gcatgtgtgc acgacgcaga tgcattacac cgtacgaact gacaccagga 7080
gctaccgtcc ctttcctgct tagcctaata tgctgcatta gaacagctaa agcggccaca 7140
taccaggagg ccgcggtata cctgtggaac gagcagcagc ctttattttg gatgcaagcc 7200
cttattccgc tggcagccct gattgtccta tgtaactgtc tgagactctt accatgctgt 7260
tgtaaaatgt tgactttttt agccgtactg agcgtcggtg cccacactgt gagcgcgtac 7320
gaacacgtaa cagtgatccc gaacacggtg ggagtaccgt ataagactct agtcaacaga 7380
ccgggctaca gccccatggt attggagatg gagcttctgt ctgtcacctt ggaaccaacg 7440
ctatcgcttg attacatcac gtgcgagtat aaaaccgtta tcccgtctcc gtacgtgaaa 7500
tgctgcggta cagcagagtg taaggacaag agcctacctg attacagctg taaggtcttc 7560
accggcgtct acccattcat gtggggcggc gcctactgct tctgcgacac cgaaaatacg 7620
caattgagcg aagcacatgt ggagaagtcc gaatcatgca aaacagaatt tgcatcagca 7680
tacagggctc ataccgcatc cgcatcagct aagctccgcg tcctttacca aggaaataat 7740
atcactgtgg ctgcttatgc aaacggcgac catgccgtca cagttaagga cgctaaattc 7800
atagtggggc caatgtcttc agcctggaca cctttcgaca ataaaatcgt ggtgtacaaa 7860
ggcgacgtct acaacatgga ctacccgccc ttcggcgcag gaagaccagg acaatttggc 7920
gacatccaaa gtcgcacgcc tgagagcgaa gacgtctatg ctaatacaca actggtactg 7980
cagagaccgt ccgcgggtac ggtgcacgtg ccgtactctc aggcaccatc tggcttcaag 8040
tattggctaa aagaacgagg ggcgtcgctg cagcacacag caccatttgg ctgtcaaata 8100
gcaacaaacc cggtaagagc gatgaactgc gccgtaggga acatgcctat ctccatcgac 8160
ataccggacg cggcctttac cagggtcgtc gacgcgccat ctttaacgga catgtcgtgt 8220
gaggtatcag cctgcaccca ttcctcagac tttgggggcg tagccatcat taaatatgca 8280
gccagtaaga aaggcaagtg tgcagtgcac tcgatgacta acgccgtcac tattcgggaa 8340
gctgaaatag aagtagaagg gaactctcag ttgcaaatct ctttttcgac ggccctagcc 8400
agcgccgaat ttcgcgtaca agtctgttct acacaagtac actgtgcagc cgagtgccat 8460
ccaccgaaag accatatagt caattacccg gcgtcacaca ccaccctcgg ggtccaagac 8520
atttccgcta cggcgatgtc atgggtgcag aagatcacgg gaggtgtggg actggttgtc 8580
gctgttgcag cactgatcct aatcgtggtg ctatgcgtgt cgtttagcag gcactaactt 8640
gacaactagg tatgaaggca tacgcgtccc taaagagaca caccgcatat agctaggaat 8700
caacagataa gtatagatct aagggctgaa caacccctga ataacaaaat ataaaaatca 8760
acaaaaatca taaaatagaa aactagaaat agaagtaggt aagaaggtat atgtgtcccc 8820
taagagacac accatatata gctaagaatc aatagataag catagatcaa agggctgaac 8880
aacccctgaa taataacaaa atataaaaac caataaaaat cataaaatag aaaatcaaca 8940
aaaatcataa aatagaaaac tagaaataga agtaggtaag aaggtatatg tgtcccctaa 9000
gagacacacc atatatagct aagaatcaat agataagcat agatcaaagg gctgaacaac 9060
ccctgaataa taacaaaata taaaaaccaa taaaaatcat aaaatagaaa accacaaata 9120
gaagtagttc aaagggctat aaaacccctg aatagtaaca aaatataaaa ctaataaaaa 9180
tcaaacgaat accataattg gcaatcggaa gagatgtagg tacttaagct tcttaaaagc 9240
agccgaactc gctttgagat gtaggcgtag cacaccgaac tcttccataa ttctccgaac 9300
ccacagggac gtaggagatg ttcaaagtga ctataaaacc ctgaacagta ataaaatata 9360
aaattaataa tgagtaccat aattggcaaa tggaagagac gtaggtacta agcttcttaa 9420
aagcagccga actcactttg agatgtaggc atagcatacc gaactcttcc acaattctcc 9480
gtacccatag ggacgtagga gatgttattt tgtttttaat atttcaaaaa aaaaaaaaaa 9540
aaaaaaaaaa aaaaaaaaaa aaaaaa 9566
<210> 48
<211> 6389
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 48
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taatctgcgt 3900
actgggacgt aagtttagat cgtccagagc attgaaacca ccatgtatca ccagtaatac 3960
tgagatgttc ttcctattta gcagttttga caatggcaga aggaatttta caacgcatgt 4020
tatgaacaat caactgaacg cagcctttgt aggacaggcc acccgagcag gatgtgcacc 4080
atcgtaccgg gtaaagcgca tggacatcgc gaagaacgat gaagagtgcg tggtcaacgc 4140
cgccaaccct cgcgggttac cgggtgacgg tgtttgcaag gcagtatata aaaaatggcc 4200
ggagtccttt aaaaatagtg caacaccagt aggaaccgca aaaacagtta tgtgcggtac 4260
atatccagta atccatgccg taggaccaaa cttctcaaat tacacggagt ccgaagggga 4320
ccgggaattg gcggctgcct atcgagaagt cgcaaaggaa gtaactagac tgggagtaaa 4380
tagcgtagct atacctctcc tctccacagg tgtatactca ggagggaaag acaggctaac 4440
ccagtcactg aaccacctct ttacagccat ggactcgacg gatgcagacg tggtcatcta 4500
ctgccgagac aaggaatggg agaagaaaat atctgaggcc atacagatgc ggacccaagt 4560
ggagctgctg gatgagcaca tctccataga ctgcgatgtc attcgcgtgc accctgacag 4620
tagtttggca ggtagaaaag gatacagcac cacggaaggc gcactgtatt catatctaga 4680
agggacacgt tttcaccaga cggcagtgga tgtggcagag atacatacta tgtggccaaa 4740
gcaaatagag gccaatgagc aagtctgcct atatgccctg ggggaaagta ttgagtcaat 4800
caggcagaaa tgcccggtgg atgatgcaga tgcatcatct cccccgaaaa ccgtcccgtg 4860
cctttgccgt tatgccatga ctcctgaacg cgtcacccga cttcgcatga accatgtcac 4920
aaatataatt gtgtgttctt catttcccct tccaaagtac aagatagaag gagtgcaaaa 4980
agtcaaatgc tccaaggtaa tgttatttga tcacaatgtg ccatcgcgcg taagtccaag 5040
ggaatacaga tcttcccagg agtctgtacg ggaagtgagt atgacaacgt cattgacgca 5100
tagtcagttt gatctaagcg ccgatggcga gacactgccc gtcccgtcag acctggatgc 5160
tgacgcccca gccctagaac cggccctaga cgacggggcg atacatacga ccggaaacct 5220
tgcggccgtg tctgactggg taatgagcac cgtacccgtc gcgccgccta gaagaaggag 5280
agggagaaac ctgaccgtga tatgtgacga gagagaaggg aatataacac ccatggctag 5340
cgtccgattc tttagagcag agcagtgtcc gaccgtacaa gaaacagcgg agacgcgtga 5400
cacagctatt tcctttcggg caccgccaag tatcaccgtg gaactgagcc atccaccgat 5460
ctccttcgga gcaccaagcg agacgttccc catcacattt ggggacttca acgatggaga 5520
aatcgaaagc ttgtcttctg agctactaac tttcggagac ttcctacccg gtgaagtgga 5580
tgatttgaca gatagcgact ggtccacgtg ctcagacacg gacgacgagg tatatgtgtc 5640
ccctaagaga cacaccatat atagctaaga atcaatagat aagcatagat caaagggctg 5700
aacaacccct gaataataac aaaatataaa aaccaataaa aatcataaaa tagaaaatca 5760
acaaaaatca taaaatagaa aactagaaat agaagtaggt aagaaggtat atgtgtcccc 5820
taagagacac accatatata gctaagaatc aatagataag catagatcaa agggctgaac 5880
aacccctgaa taataacaaa atataaaaac caataaaaat cataaaatag aaaaccacaa 5940
atagaagtag ttcaaagggc tataaaaccc ctgaatagta acaaaatata aaactaataa 6000
aaatcaaacg aataccataa ttggcaatcg gaagagatgt aggtacttaa gcttcttaaa 6060
agcagccgaa ctcgctttga gatgtaggcg tagcacaccg aactcttcca taattctccg 6120
aacccacagg gacgtaggag atgttcaaag tgactataaa accctgaaca gtaataaaat 6180
ataaaattaa taatgagtac cataattggc aaatggaaga gacgtaggta ctaagcttct 6240
taaaagcagc cgaactcact ttgagatgta ggcatagcat accgaactct tccacaattc 6300
tccgtaccca tagggacgta ggagatgtta ttttgttttt aatatttcaa aaaaaaaaaa 6360
aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 6389
<210> 49
<211> 6598
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 49
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taatctgcgt 3900
actgggacgt aagtttagat cgtccagagc attgaaacca ccatgtatca ccagtaatac 3960
tgagatgttc ttcctattta gcagttttga caatggcaga aggaatttta caacgcatgt 4020
tatgaacaat caactgaacg cagcctttgt aggacaggcc acccgagcag gatgtgcacc 4080
atcgtaccgg gtaaagcgca tggacatcgc gaagaacgat gaagagtgcg tggtcaacgc 4140
cgccaaccct cgcgggttac cgggtgacgg tgtttgcaag gcagtatata aaaaatggcc 4200
ggagtccttt aaaaatagtg caacaccagt aggaaccgca aaaacagtta tgtgcggtac 4260
atatccagta atccatgccg taggaccaaa cttctcaaat tacacggagt ccgaagggga 4320
ccgggaattg gcggctgcct atcgagaagt cgcaaaggaa gtaactagac tgggagtaaa 4380
tagcgtagct atacctctcc tctccacagg tgtatactca ggagggaaag acaggctaac 4440
ccagtcactg aaccacctct ttacagccat ggactcgacg gatgcagacg tggtcatcta 4500
ctgccgagac aaggaatggg agaagaaaat atctgaggcc atacagatgc ggacccaagt 4560
ggagctgctg gatgagcaca tctccataga ctgcgatgtc attcgcgtgc accctgacag 4620
tagtttggca ggtagaaaag gatacagcac cacggaaggc gcactgtatt catatctaga 4680
agggacacgt tttcaccaga cggcagtgga tgtggcagag atacatacta tgtggccaaa 4740
gcaaatagag gccaatgagc aagtctgcct atatgccctg ggggaaagta ttgagtcaat 4800
caggcagaaa tgcccggtgg atgatgcaga tgcatcatct cccccgaaaa ccgtcccgtg 4860
cctttgccgt tatgccatga ctcctgaacg cgtcacccga cttcgcatga accatgtcac 4920
aaatataatt gtgtgttctt catttcccct tccaaagtac aagatagaag gagtgcaaaa 4980
agtcaaatgc tccaaggtaa tgttatttga tcacaatgtg ccatcgcgcg taagtccaag 5040
ggaatacaga tcttcccagg agtctgtacg ggaagtgagt atgacaacgt cattgacgca 5100
tagtcagttt gatctaagcg ccgatggcga gacactgccc gtcccgtcag acctggatgc 5160
tgacgcccca gccctagaac cggccctaga cgacggggcg atacatacga ccggaaacct 5220
tgcggccgtg tctgactggg taatgagcac cgtacccgtc gcgccgccta gaagaaggag 5280
agggagaaac ctgaccgtga tatgtgacga gagagaaggg aatataacac ccatggctag 5340
cgtccgattc tttagagcag agcagtgtcc gaccgtacaa gaaacagcgg agacgcgtga 5400
cacagctatt tcctttcggg caccgccaag tatcaccgtg gaactgagcc atccaccgat 5460
ctccttcgga gcaccaagcg agacgttccc catcacattt ggggacttca acgatggaga 5520
aatcgaaagc ttgtcttctg agctactaac tttcggagac ttcctacccg gtgaagtgga 5580
tgatttgaca gatagcgact ggtccacgtg ctcagacacg gacgacgagt tatgactaga 5640
cagggcaggt gggtatatat tctcgtcgga caccggtcca ggccatttac aacagaagtc 5700
ggtacgccag tcagtgctgc cggtaaacac cctggaggaa gttcacgagg agaagtgtta 5760
cccacctaag ctggatgaat taaaggagca actactactt aagaaactcc aggagagtgc 5820
gtccacggcc aatagaagca ggtatcaatc acgcaaagtg gaaaatatga aagcaacaat 5880
catccagaga ctaaaggatc aaagggctga acaacccctg aataataaca aaatataaaa 5940
accaataaaa atcataaaat agaaaatcaa caaaaatcat aaaatagaaa actagaaata 6000
gaagtaggta agaaggtata tgtgtcccct aagagacaca ccatatatag ctaagaatca 6060
atagataagc atagatcaaa gggctgaaca acccctgaat aataacaaaa tataaaaacc 6120
aataaaaatc ataaaataga aaaccacaaa tagaagtagt tcaaagggct ataaaacccc 6180
tgaatagtaa caaaatataa aactaataaa aatcaaacga ataccataat tggcaatcgg 6240
aagagatgta ggtacttaag cttcttaaaa gcagccgaac tcgctttgag atgtaggcgt 6300
agcacaccga actcttccat aattctccga acccacaggg acgtaggaga tgttcaaagt 6360
gactataaaa ccctgaacag taataaaata taaaattaat aatgagtacc ataattggca 6420
aatggaagag acgtaggtac taagcttctt aaaagcagcc gaactcactt tgagatgtag 6480
gcatagcata ccgaactctt ccacaattct ccgtacccat agggacgtag gagatgttat 6540
tttgttttta atatttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 6598
<210> 50
<211> 6628
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 50
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taatctgcgt 3900
actgggacgt aagtttagat cgtccagagc attgaaacca ccatgtatca ccagtaatac 3960
tgagatgttc ttcctattta gcagttttga caatggcaga aggaatttta caacgcatgt 4020
tatgaacaat caactgaacg cagcctttgt aggacaggcc acccgagcag gatgtgcacc 4080
atcgtaccgg gtaaagcgca tggacatcgc gaagaacgat gaagagtgcg tggtcaacgc 4140
cgccaaccct cgcgggttac cgggtgacgg tgtttgcaag gcagtatata aaaaatggcc 4200
ggagtccttt aaaaatagtg caacaccagt aggaaccgca aaaacagtta tgtgcggtac 4260
atatccagta atccatgccg taggaccaaa cttctcaaat tacacggagt ccgaagggga 4320
ccgggaattg gcggctgcct atcgagaagt cgcaaaggaa gtaactagac tgggagtaaa 4380
tagcgtagct atacctctcc tctccacagg tgtatactca ggagggaaag acaggctaac 4440
ccagtcactg aaccacctct ttacagccat ggactcgacg gatgcagacg tggtcatcta 4500
ctgccgagac aaggaatggg agaagaaaat atctgaggcc atacagatgc ggacccaagt 4560
ggagctgctg gatgagcaca tctccataga ctgcgatgtc attcgcgtgc accctgacag 4620
tagtttggca ggtagaaaag gatacagcac cacggaaggc gcactgtatt catatctaga 4680
agggacacgt tttcaccaga cggcagtgga tgtggcagag atacatacta tgtggccaaa 4740
gcaaatagag gccaatgagc aagtctgcct atatgccctg ggggaaagta ttgagtcaat 4800
caggcagaaa tgcccggtgg atgatgcaga tgcatcatct cccccgaaaa ccgtcccgtg 4860
cctttgccgt tatgccatga ctcctgaacg cgtcacccga cttcgcatga accatgtcac 4920
aaatataatt gtgtgttctt catttcccct tccaaagtac aagatagaag gagtgcaaaa 4980
agtcaaatgc tccaaggtaa tgttatttga tcacaatgtg ccatcgcgcg taagtccaag 5040
ggaatacaga tcttcccagg agtctgtacg ggaagtgagt atgacaacgt cattgacgca 5100
tagtcagttt gatctaagcg ccgatggcga gacactgccc gtcccgtcag acctggatgc 5160
tgacgcccca gccctagaac cggccctaga cgacggggcg atacatacga ccggaaacct 5220
tgcggccgtg tctgactggg taatgagcac cgtacccgtc gcgccgccta gaagaaggag 5280
agggagaaac ctgaccgtga tatgtgacga gagagaaggg aatataacac ccatggctag 5340
cgtccgattc tttagagcag agcagtgtcc gaccgtacaa gaaacagcgg agacgcgtga 5400
cacagctatt tcctttcggg caccgccaag tatcaccgtg gaactgagcc atccaccgat 5460
ctccttcgga gcaccaagcg agacgttccc catcacattt ggggacttca acgatggaga 5520
aatcgaaagc ttgtcttctg agctactaac tttcggagac ttcctacccg gtgaagtgga 5580
tgatttgaca gatagcgact ggtccacgtg ctcagacacg gacgacgagt tatgactaga 5640
cagggcaggt gggtatatat tctcgtcgga caccggtcca ggccatttac aacagaagtc 5700
ggtacgccag tcagtgctgc cggtaaacac cctggaggaa gttcacgagg agaagtgtta 5760
cccacctaag ctggatgaat taaaggagca actactactt aagaaactcc aggagagtgc 5820
gtccacggcc aatagaagca ggtatcaatc acgcaaagtg gaaaatatga aagcaacaat 5880
catccagaga ctaaagagag gctgtaaact gtatttaatg gcagagaccc cgaaagtccc 5940
gacttatcgg accgtatacc cggcgcctgt gtactcgcct ccgatcaacg tccgattgtc 6000
caatcccgag tccgcagtgg cagcatgtaa tgagttctta gctagaaact acccaactgt 6060
ttcatcatac caaatcaccg atgagtatga tgcatatcta gacatggtgg acgggtcgga 6120
gagttgcttg gaccgagcga cattcaatcc gtcaaaactt aggagctacc cgaaacaaca 6180
tggaagtagt tcaaagggct ataaaacccc tgaatagtaa caaaatataa aactaataaa 6240
aatcaaacga ataccataat tggcaatcgg aagagatgta ggtacttaag cttcttaaaa 6300
gcagccgaac tcgctttgag atgtaggcgt agcacaccga actcttccat aattctccga 6360
acccacaggg acgtaggaga tgttcaaagt gactataaaa ccctgaacag taataaaata 6420
taaaattaat aatgagtacc ataattggca aatggaagag acgtaggtac taagcttctt 6480
aaaagcagcc gaactcactt tgagatgtag gcatagcata ccgaactctt ccacaattct 6540
ccgtacccat agggacgtag gagatgttat tttgttttta atatttcaaa aaaaaaaaaa 6600
aaaaaaaaaa aaaaaaaaaa aaaaaaaa 6628
<210> 51
<211> 9138
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 51
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga ttcaatccgt 3060
caaaacttag gagctacccg aaacaacatg cttatcacgc gccctctatc agaagcgctg 3120
taccttcccc attccagaac acactacaga atgtactggc agcagccacg aaaaggaact 3180
gcaacgtcac acagatgagg gaattaccca ctttggactc agcagtattc aacgtggagt 3240
gttttaaaaa attcgcatgc aaccgagaat actgggaaga atttgctgcc agccctatca 3300
ggataacgac tgagaatcta acaacctatg tcactaaatt aaaggggcca aaagcagcag 3360
cgttgcttgc aagaacccat aatctgctgc cgctgcagga tgtaccaatg gataggttca 3420
cagtagatat gaaaagggac gtgaaggtaa ctcctggcac aaagcataca gaggaaaggc 3480
ctaaggtgca ggttatacag gcggctgaac ccttggcaac agcgtaccta tgtggaattc 3540
acagagaatt ggttaggaga ttgaacgccg tcctcctacc caacgtgcat acactatttg 3600
acatgtctgc cgaggacttc gatgccatta tagccgcaca ctttaagcca ggagacgccg 3660
ttttagaaac ggacatagcc tcctttgata agagccagga tgattcactt gcgcttaccg 3720
ccttaatgct gttagaagat ttgggagtgg atcactcctt gttggacctg atagaggctg 3780
cttttggaga gatttccagc tgtcacctgc cgacaggtac gcgcttcaag ttcggcgcta 3840
tgatgaaatc cggtatgttc ctaactctgt tcgtcaacac attgttaaat atcaccatcg 3900
ctagccgggt gttggaagat cgtctgacaa aatctgcatg cgcggccttc atcggcgacg 3960
acaacataat acatggtgtc gtctccgatg aattgatggc agccagatgc gctacttgga 4020
tgaacatgga agtgaagatc atagatgcag ttgtatccca gaaagctccc tacttttgtg 4080
gagggtttat actgcatgat actgtgacag gaacagcttg cagggtggcg gacccgctaa 4140
aaaggttatt taaactgggc aaaccgttag cggcaggtga cgaacaagac gaagacagaa 4200
ggcgggcgct ggctgatgaa gtaatcagat ggcaacgaac agggctaata gatgagctgg 4260
agaaagcggt gtactctagg tacgaagtgc agggtatatc agttgctgta atgtccatgg 4320
ccacctttgc aagctccaga tccaacttcg agaagctcag aggacccgtc ataaccttgt 4380
acggcggtcc taaataggta cgcactacag ctacctattt tgcaaaagcc gacagcaggt 4440
acctaaatac caatcagcca taatggagtt tatcccaacc caaactttct acaataggag 4500
gtaccagcct cgaccttgga ctccgcgccc tactatccaa gtcatcagac ccagaccgcg 4560
tccgcaaagg aaggccgggc aacttgccca gctgatctca gcagttaata aactgacaat 4620
gcgcgtggta cctcaacaga agccgcgcaa gaatcggaag aataagaagc aaaagcaaaa 4680
gcagcaggcg ccacgaaaca atacgaatca aaagaagcag ccccccaaaa agaaaccggt 4740
tcaaaagaaa aagaagccgg gccgcagaga gagaatgtgc atgaaaatcg aaaatgattg 4800
catcttcgaa gtcaagcatg aaggtaaggt aacaggttac gcgtgcttgg taggggacaa 4860
agtaatgaag ccagcacacg taaaggggac catcgataac gcggacctgg ccaaattggc 4920
cttcaagcgg tcatctaagt acgaccttga atgcgcgcag atacccgtgc acatgaagtc 4980
cgacgcttcg aagttcaccc atgagaaacc ggaggggtac tacaactggc accacggagc 5040
agtacagtac tcaggaggcc gattcaccat ccctacaggt gcgggcaaac caggggatag 5100
tggtagaccg atcttcgaca acaaggggcg cgtggtggcc atagttttag gaggagctaa 5160
tgaaggagcc cgtacagccc tctcggtggt gacctggaac aaagacatcg tcacgaaaat 5220
cacccctgag ggggccgaag agtggagtct ggccattcca gttatgtgcc tgctggcaaa 5280
taccacgttc ccctgctccc ggcccccttg cacaccctgc tgctacgaaa aagagccgga 5340
gaaaaccttg cgcatgcttg aagacaatgt catgagcccc gggtactatc agctgctaca 5400
agcatcctta acatgttctc cccgacgcca gcggcgcagt attaaggacc acttcaatgt 5460
ctataaagcc acaagaccgt acctagctca ctgtcccgac tgtggagaag ggcactcgtg 5520
ccatagtccc gtagcgctag aacgcatcag aaacgaagcg acagacggga cgttgaaaat 5580
ccaggtttcc ttgcaaatcg gaataaagac ggatgatagc catgattgga ccaagctgcg 5640
ttatatggac aatcacatgc cagcagacgc agagcgggcc gggctatttg taagaacgtc 5700
agcaccgtgc acgattactg gaacaatggg acacttcatt ctggcccgat gtccgaaagg 5760
agaaactctg acggtggggt tcactgacgg taggaagatc agtcactcat gtacgcaccc 5820
atttcaccat gaccctcctg tgataggccg ggaaaaattc cattcccgac cgcagcacgg 5880
tagggaacta ccttgcagca cgtacgcgca gagcaccgct gcaactgccg aggagataga 5940
ggtacacatg cccccagaca ccccagatcg cacattaatg tcacaacagt ccggcaatgt 6000
aaagatcaca gtcaatagtc agacggtgcg gtacaagtgc aattgtggtg actcaagtga 6060
aggattaacc actacagata aagtgattaa taactgcaag gtcgatcaat gccatgccgc 6120
ggtcaccaat cacaaaaaat ggcagtataa ttcccctctg gtcccgcgta atgctgaatt 6180
cggggaccgg aaaggaaaag ttcacattcc atttcctctg gcaaatgtga catgcagggt 6240
gcctaaagca agaaacccca ccgtgacgta cggaaaaaac caagtcatca tgttgctgta 6300
tcctgaccac ccaacgctcc tgtcctacag gaatatggga gaagaaccaa actatcaaga 6360
agagtgggtg acgcataaga aggagatcag gttaaccgtg ccgactgagg ggctcgaggt 6420
cacgtggggt aacaatgagc cgtacaagta ttggccgcag ttatccacaa acggtacagc 6480
ccacggccac ccgcatgaga taattctgta ttattatgag ctgtacccaa ctatgactgc 6540
ggtagttttg tcagtggcct cgttcatact cctgtcgatg gtgggtgtgg cagtggggat 6600
gtgcatgtgt gcacgacgca gatgcattac accgtacgaa ctgacaccag gagctaccgt 6660
ccctttcctg cttagcctaa tatgctgcat tagaacagct aaagcggcca cataccagga 6720
ggccgcggta tacctgtgga acgagcagca gcctttattt tggatgcaag cccttattcc 6780
gctggcagcc ctgattgtcc tatgtaactg tctgagactc ttaccatgct gttgtaaaat 6840
gttgactttt ttagccgtac tgagcgtcgg tgcccacact gtgagcgcgt acgaacacgt 6900
aacagtgatc ccgaacacgg tgggagtacc gtataagact ctagtcaaca gaccgggcta 6960
cagccccatg gtattggaga tggagcttct gtctgtcacc ttggaaccaa cgctatcgct 7020
tgattacatc acgtgcgagt ataaaaccgt tatcccgtct ccgtacgtga aatgctgcgg 7080
tacagcagag tgtaaggaca agagcctacc tgattacagc tgtaaggtct tcaccggcgt 7140
ctacccattc atgtggggcg gcgcctactg cttctgcgac accgaaaata cgcaattgag 7200
cgaagcacat gtggagaagt ccgaatcatg caaaacagaa tttgcatcag catacagggc 7260
tcataccgca tccgcatcag ctaagctccg cgtcctttac caaggaaata atatcactgt 7320
ggctgcttat gcaaacggcg accatgccgt cacagttaag gacgctaaat tcatagtggg 7380
gccaatgtct tcagcctgga cacctttcga caataaaatc gtggtgtaca aaggcgacgt 7440
ctacaacatg gactacccgc ccttcggcgc aggaagacca ggacaatttg gcgacatcca 7500
aagtcgcacg cctgagagcg aagacgtcta tgctaataca caactggtac tgcagagacc 7560
gtccgcgggt acggtgcacg tgccgtactc tcaggcacca tctggcttca agtattggct 7620
aaaagaacga ggggcgtcgc tgcagcacac agcaccattt ggctgtcaaa tagcaacaaa 7680
cccggtaaga gcgatgaact gcgccgtagg gaacatgcct atctccatcg acataccgga 7740
cgcggccttt accagggtcg tcgacgcgcc atctttaacg gacatgtcgt gtgaggtatc 7800
agcctgcacc cattcctcag actttggggg cgtagccatc attaaatatg cagccagtaa 7860
gaaaggcaag tgtgcagtgc actcgatgac taacgccgtc actattcggg aagctgaaat 7920
agaagtagaa gggaactctc agttgcaaat ctctttttcg acggccctag ccagcgccga 7980
atttcgcgta caagtctgtt ctacacaagt acactgtgca gccgagtgcc atccaccgaa 8040
agaccatata gtcaattacc cggcgtcaca caccaccctc ggggtccaag acatttccgc 8100
tacggcgatg tcatgggtgc agaagatcac gggaggtgtg ggactggttg tcgctgttgc 8160
agcactgatc ctaatcgtgg tgctatgcgt gtcgtttagc aggcactaac ttgacaacta 8220
ggtatgaagg catacgcgtc cctaaagaga cacaccgcat atagctagga atcaacagat 8280
aagtatagat ctaagggctg aacaacccct gaataacaaa atataaaaat caacaaaaat 8340
cataaaatag aaaactagaa atagaagtag gtaagaaggt atatgtgtcc cctaagagac 8400
acaccatata tagctaagaa tcaatagata agcatagatc aaagggctga acaacccctg 8460
aataataaca aaatataaaa accaataaaa atcataaaat agaaaatcaa caaaaatcat 8520
aaaatagaaa actagaaata gaagtaggta agaaggtata tgtgtcccct aagagacaca 8580
ccatatatag ctaagaatca atagataagc atagatcaaa gggctgaaca acccctgaat 8640
aataacaaaa tataaaaacc aataaaaatc ataaaataga aaaccacaaa tagaagtagt 8700
tcaaagggct ataaaacccc tgaatagtaa caaaatataa aactaataaa aatcaaacga 8760
ataccataat tggcaatcgg aagagatgta ggtacttaag cttcttaaaa gcagccgaac 8820
tcgctttgag atgtaggcgt agcacaccga actcttccat aattctccga acccacaggg 8880
acgtaggaga tgttcaaagt gactataaaa ccctgaacag taataaaata taaaattaat 8940
aatgagtacc ataattggca aatggaagag acgtaggtac taagcttctt aaaagcagcc 9000
gaactcactt tgagatgtag gcatagcata ccgaactctt ccacaattct ccgtacccat 9060
agggacgtag gagatgttat tttgttttta atatttcaaa aaaaaaaaaa aaaaaaaaaa 9120
aaaaaaaaaa aaaaaaaa 9138
<210> 52
<211> 10258
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 52
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aaatgagaca gagaggtcta gaaatatctg cacgtacggt tgattcgctg 420
ctcttgaatg gatgcaatag accagtcgac gtgttgtacg tagacgaggc gtttgcgtgc 480
cactctggaa cgttacttgc cttgatcgcc ttggtgagac caagactgaa agttgtactt 540
tgtggtgacc cgaagcagtg cggcttcttc aatatgatgc agatgaaagt caactacaat 600
cataacatct gcactcaagt gtaccacaaa agtatttcca ggcggtgtac actgcctgtg 660
actgccattg tgtcgtcgtt gcattacgaa ggcaaaatgc gcactacgaa tgagtacaac 720
atgccgattg tagtggacac tacgggctca acaaaacctg accctggaga cctcgtgtta 780
acgtgcttca gagggtgggt taaacaactg caaattgact atcgtggaca cgaggtcatg 840
acagcagccg catcccaagg gttaaccaga aaaggagttt acgcagttag gcaaaaagtt 900
aacgaaaacc cactctatgc atcaacatca gagcacgtca acgtactcct aacgcgtacg 960
gaaggtaaac tggtatggaa gacactctct ggtgacccgt ggataaagac gctgcagaac 1020
ccaccgaaag gaaacttcaa ggcaactatt aaggagtggg aggtggagca cgcatcgata 1080
atggcgggca tctgcagtca ccaagtgacc tttgacacgt tccaaaacaa agccaacgtt 1140
tgctgggcta agagcttggt ccctatcctc gaaacagcgg ggataaaact aaatgatagg 1200
cagtggtccc agataattca agctttcaaa gaagacaaag catactcacc cgaagtagcc 1260
ctgaatgaaa tatgcacgcg catgtatggg gtggatctag acagcgggct attctctaaa 1320
ccgttggtat ctgtgtatta cgcggataac cactgggata ataggccggg aggaaagatg 1380
ttcggattca accctgaggc agcgtccatt ctagaaagaa agtacccgtt tacaaaagga 1440
aagtggaaca tcaacaagca gatctgcgtg actaccagga ggatagaaga cttcaaccct 1500
accaccaaca ttataccggc caacaggaga ctaccacact cattagtggc cgaacaccgc 1560
ccagtaaaag gggaaagaat ggaatggctg gttaacaaga taaacggaca tcatgtgctc 1620
ctggttagcg gctataacct tgcactgcct actaagagag tcacctgggt agcgccacta 1680
ggtgtccgcg gagcggacta tacatacaac ctagagctgg gtctaccggc aacacttggt 1740
aggtatgacc tagtggtcat aaacatccac acaccttttc gcatacacca ttaccaacag 1800
tgcgtagatc acgcaatgaa actgcaaatg ctaggaggtg actcactgag actgctcaaa 1860
ccgggtggct ctctattgat cagagcatac ggttacgcag atagaaccag tgaacgagta 1920
atctgcgtac tgggacgtaa gtttagatcg tccagagcat tgaaaccacc atgtatcacc 1980
agtaatactg agatgttctt cctatttagc agttttgaca atggcagaag gaattttaca 2040
acgcatgtta tgaacaatca actgaacgca gcctttgtag gacaggccac ccgagcagga 2100
tgtgcaccat cgtaccgggt aaagcgcatg gacatcgcga agaacgatga agagtgcgtg 2160
gtcaacgccg ccaaccctcg cgggttaccg ggtgacggtg tttgcaaggc agtatataaa 2220
aaatggccgg agtcctttaa aaatagtgca acaccagtag gaaccgcaaa aacagttatg 2280
tgcggtacat atccagtaat ccatgccgta ggaccaaact tctcaaatta cacggagtcc 2340
gaaggggacc gggaattggc ggctgcctat cgagaagtcg caaaggaagt aactagactg 2400
ggagtaaata gcgtagctat acctctcctc tccacaggtg tatactcagg agggaaagac 2460
aggctaaccc agtcactgaa ccacctcttt acagccatgg actcgacgga tgcagacgtg 2520
gtcatctact gccgagacaa ggaatgggag aagaaaatat ctgaggccat acagatgcgg 2580
acccaagtgg agctgctgga tgagcacatc tccatagact gcgatgtcat tcgcgtgcac 2640
cctgacagta gtttggcagg tagaaaagga tacagcacca cggaaggcgc actgtattca 2700
tatctagaag ggacacgttt tcaccagacg gcagtggatg tggcagagat acatactatg 2760
tggccaaagc aaatagaggc caatgagcaa gtctgcctat atgccctggg ggaaagtatt 2820
gagtcaatca ggcagaaatg cccggtggat gatgcagatg catcatctcc cccgaaaacc 2880
gtcccgtgcc tttgccgtta tgccatgact cctgaacgcg tcacccgact tcgcatgaac 2940
catgtcacaa atataattgt gtgttcttca tttccccttc caaagtacaa gatagaagga 3000
gtgcaaaaag tcaaatgctc caaggtaatg ttatttgatc acaatgtgcc atcgcgcgta 3060
agtccaaggg aatacagatc ttcccaggag tctgtacggg aagtgagtat gacaacgtca 3120
ttgacgcata gtcagtttga tctaagcgcc gatggcgaga cactgcccgt cccgtcagac 3180
ctggatgctg acgccccagc cctagaaccg gccctagacg acggggcgat acatacgacc 3240
ggaaaccttg cggccgtgtc tgactgggta atgagcaccg tacccgtcgc gccgcctaga 3300
agaaggagag ggagaaacct gaccgtgata tgtgacgaga gagaagggaa tataacaccc 3360
atggctagcg tccgattctt tagagcagag cagtgtccga ccgtacaaga aacagcggag 3420
acgcgtgaca cagctatttc ctttcgggca ccgccaagta tcaccgtgga actgagccat 3480
ccaccgatct ccttcggagc accaagcgag acgttcccca tcacatttgg ggacttcaac 3540
gatggagaaa tcgaaagctt gtcttctgag ctactaactt tcggagactt cctacccggt 3600
gaagtggatg atttgacaga tagcgactgg tccacgtgct cagacacgga cgacgagtta 3660
tgactagaca gggcaggtgg gtatatattc tcgtcggaca ccggtccagg ccatttacaa 3720
cagaagtcgg tacgccagtc agtgctgccg gtaaacaccc tggaggaagt tcacgaggag 3780
aagtgttacc cacctaagct ggatgaatta aaggagcaac tactacttaa gaaactccag 3840
gagagtgcgt ccacggccaa tagaagcagg tatcaatcac gcaaagtgga aaatatgaaa 3900
gcaacaatca tccagagact aaagagaggc tgtaaactgt atttaatggc agagaccccg 3960
aaagtcccga cttatcggac cgtatacccg gcgcctgtgt actcgcctcc gatcaacgtc 4020
cgattgtcca atcccgagtc cgcagtggca gcatgtaatg agttcttagc tagaaactac 4080
ccaactgttt catcatacca aatcaccgat gagtatgatg catatctaga catggtggac 4140
gggtcggaga gttgcttgga ccgagcgaca ttcaatccgt caaaacttag gagctacccg 4200
aaacaacatg cttatcacgc gccctctatc agaagcgctg taccttcccc attccagaac 4260
acactacaga atgtactggc agcagccacg aaaaggaact gcaacgtcac acagatgagg 4320
gaattaccca ctttggactc agcagtattc aacgtggagt gttttaaaaa attcgcatgc 4380
aaccgagaat actgggaaga atttgctgcc agccctatca ggataacgac tgagaatcta 4440
acaacctatg tcactaaatt aaaggggcca aaagcagcag cgttgcttgc aagaacccat 4500
aatctgctgc cgctgcagga tgtaccaatg gataggttca cagtagatat gaaaagggac 4560
gtgaaggtaa ctcctggcac aaagcataca gaggaaaggc ctaaggtgca ggttatacag 4620
gcggctgaac ccttggcaac agcgtaccta tgtggaattc acagagaatt ggttaggaga 4680
ttgaacgccg tcctcctacc caacgtgcat acactatttg acatgtctgc cgaggacttc 4740
gatgccatta tagccgcaca ctttaagcca ggagacgccg ttttagaaac ggacatagcc 4800
tcctttgata agagccagga tgattcactt gcgcttaccg ccttaatgct gttagaagat 4860
ttgggagtgg atcactcctt gttggacctg atagaggctg cttttggaga gatttccagc 4920
tgtcacctgc cgacaggtac gcgcttcaag ttcggcgcta tgatgaaatc cggtatgttc 4980
ctaactctgt tcgtcaacac attgttaaat atcaccatcg ctagccgggt gttggaagat 5040
cgtctgacaa aatctgcatg cgcggccttc atcggcgacg acaacataat acatggtgtc 5100
gtctccgatg aattgatggc agccagatgc gctacttgga tgaacatgga agtgaagatc 5160
atagatgcag ttgtatccca gaaagctccc tacttttgtg gagggtttat actgcatgat 5220
actgtgacag gaacagcttg cagggtggcg gacccgctaa aaaggttatt taaactgggc 5280
aaaccgttag cggcaggtga cgaacaagac gaagacagaa ggcgggcgct ggctgatgaa 5340
gtaatcagat ggcaacgaac agggctaata gatgagctgg agaaagcggt gtactctagg 5400
tacgaagtgc agggtatatc agttgctgta atgtccatgg ccacctttgc aagctccaga 5460
tccaacttcg agaagctcag aggacccgtc ataaccttgt acggcggtcc taaataggta 5520
cgcactacag ctacctattt tgcaaaagcc gacagcaggt acctaaatac caatcagcca 5580
taatggagtt tatcccaacc caaactttct acaataggag gtaccagcct cgaccttgga 5640
ctccgcgccc tactatccaa gtcatcagac ccagaccgcg tccgcaaagg aaggccgggc 5700
aacttgccca gctgatctca gcagttaata aactgacaat gcgcgtggta cctcaacaga 5760
agccgcgcaa gaatcggaag aataagaagc aaaagcaaaa gcagcaggcg ccacgaaaca 5820
atacgaatca aaagaagcag ccccccaaaa agaaaccggt tcaaaagaaa aagaagccgg 5880
gccgcagaga gagaatgtgc atgaaaatcg aaaatgattg catcttcgaa gtcaagcatg 5940
aaggtaaggt aacaggttac gcgtgcttgg taggggacaa agtaatgaag ccagcacacg 6000
taaaggggac catcgataac gcggacctgg ccaaattggc cttcaagcgg tcatctaagt 6060
acgaccttga atgcgcgcag atacccgtgc acatgaagtc cgacgcttcg aagttcaccc 6120
atgagaaacc ggaggggtac tacaactggc accacggagc agtacagtac tcaggaggcc 6180
gattcaccat ccctacaggt gcgggcaaac caggggatag tggtagaccg atcttcgaca 6240
acaaggggcg cgtggtggcc atagttttag gaggagctaa tgaaggagcc cgtacagccc 6300
tctcggtggt gacctggaac aaagacatcg tcacgaaaat cacccctgag ggggccgaag 6360
agtggagtct ggccattcca gttatgtgcc tgctggcaaa taccacgttc ccctgctccc 6420
ggcccccttg cacaccctgc tgctacgaaa aagagccgga gaaaaccttg cgcatgcttg 6480
aagacaatgt catgagcccc gggtactatc agctgctaca agcatcctta acatgttctc 6540
cccgacgcca gcggcgcagt attaaggacc acttcaatgt ctataaagcc acaagaccgt 6600
acctagctca ctgtcccgac tgtggagaag ggcactcgtg ccatagtccc gtagcgctag 6660
aacgcatcag aaacgaagcg acagacggga cgttgaaaat ccaggtttcc ttgcaaatcg 6720
gaataaagac ggatgatagc catgattgga ccaagctgcg ttatatggac aatcacatgc 6780
cagcagacgc agagcgggcc gggctatttg taagaacgtc agcaccgtgc acgattactg 6840
gaacaatggg acacttcatt ctggcccgat gtccgaaagg agaaactctg acggtggggt 6900
tcactgacgg taggaagatc agtcactcat gtacgcaccc atttcaccat gaccctcctg 6960
tgataggccg ggaaaaattc cattcccgac cgcagcacgg tagggaacta ccttgcagca 7020
cgtacgcgca gagcaccgct gcaactgccg aggagataga ggtacacatg cccccagaca 7080
ccccagatcg cacattaatg tcacaacagt ccggcaatgt aaagatcaca gtcaatagtc 7140
agacggtgcg gtacaagtgc aattgtggtg actcaagtga aggattaacc actacagata 7200
aagtgattaa taactgcaag gtcgatcaat gccatgccgc ggtcaccaat cacaaaaaat 7260
ggcagtataa ttcccctctg gtcccgcgta atgctgaatt cggggaccgg aaaggaaaag 7320
ttcacattcc atttcctctg gcaaatgtga catgcagggt gcctaaagca agaaacccca 7380
ccgtgacgta cggaaaaaac caagtcatca tgttgctgta tcctgaccac ccaacgctcc 7440
tgtcctacag gaatatggga gaagaaccaa actatcaaga agagtgggtg acgcataaga 7500
aggagatcag gttaaccgtg ccgactgagg ggctcgaggt cacgtggggt aacaatgagc 7560
cgtacaagta ttggccgcag ttatccacaa acggtacagc ccacggccac ccgcatgaga 7620
taattctgta ttattatgag ctgtacccaa ctatgactgc ggtagttttg tcagtggcct 7680
cgttcatact cctgtcgatg gtgggtgtgg cagtggggat gtgcatgtgt gcacgacgca 7740
gatgcattac accgtacgaa ctgacaccag gagctaccgt ccctttcctg cttagcctaa 7800
tatgctgcat tagaacagct aaagcggcca cataccagga ggccgcggta tacctgtgga 7860
acgagcagca gcctttattt tggatgcaag cccttattcc gctggcagcc ctgattgtcc 7920
tatgtaactg tctgagactc ttaccatgct gttgtaaaat gttgactttt ttagccgtac 7980
tgagcgtcgg tgcccacact gtgagcgcgt acgaacacgt aacagtgatc ccgaacacgg 8040
tgggagtacc gtataagact ctagtcaaca gaccgggcta cagccccatg gtattggaga 8100
tggagcttct gtctgtcacc ttggaaccaa cgctatcgct tgattacatc acgtgcgagt 8160
ataaaaccgt tatcccgtct ccgtacgtga aatgctgcgg tacagcagag tgtaaggaca 8220
agagcctacc tgattacagc tgtaaggtct tcaccggcgt ctacccattc atgtggggcg 8280
gcgcctactg cttctgcgac accgaaaata cgcaattgag cgaagcacat gtggagaagt 8340
ccgaatcatg caaaacagaa tttgcatcag catacagggc tcataccgca tccgcatcag 8400
ctaagctccg cgtcctttac caaggaaata atatcactgt ggctgcttat gcaaacggcg 8460
accatgccgt cacagttaag gacgctaaat tcatagtggg gccaatgtct tcagcctgga 8520
cacctttcga caataaaatc gtggtgtaca aaggcgacgt ctacaacatg gactacccgc 8580
ccttcggcgc aggaagacca ggacaatttg gcgacatcca aagtcgcacg cctgagagcg 8640
aagacgtcta tgctaataca caactggtac tgcagagacc gtccgcgggt acggtgcacg 8700
tgccgtactc tcaggcacca tctggcttca agtattggct aaaagaacga ggggcgtcgc 8760
tgcagcacac agcaccattt ggctgtcaaa tagcaacaaa cccggtaaga gcgatgaact 8820
gcgccgtagg gaacatgcct atctccatcg acataccgga cgcggccttt accagggtcg 8880
tcgacgcgcc atctttaacg gacatgtcgt gtgaggtatc agcctgcacc cattcctcag 8940
actttggggg cgtagccatc attaaatatg cagccagtaa gaaaggcaag tgtgcagtgc 9000
actcgatgac taacgccgtc actattcggg aagctgaaat agaagtagaa gggaactctc 9060
agttgcaaat ctctttttcg acggccctag ccagcgccga atttcgcgta caagtctgtt 9120
ctacacaagt acactgtgca gccgagtgcc atccaccgaa agaccatata gtcaattacc 9180
cggcgtcaca caccaccctc ggggtccaag acatttccgc tacggcgatg tcatgggtgc 9240
agaagatcac gggaggtgtg ggactggttg tcgctgttgc agcactgatc ctaatcgtgg 9300
tgctatgcgt gtcgtttagc aggcactaac ttgacaacta ggtatgaagg catacgcgtc 9360
cctaaagaga cacaccgcat atagctagga atcaacagat aagtatagat ctaagggctg 9420
aacaacccct gaataacaaa atataaaaat caacaaaaat cataaaatag aaaactagaa 9480
atagaagtag gtaagaaggt atatgtgtcc cctaagagac acaccatata tagctaagaa 9540
tcaatagata agcatagatc aaagggctga acaacccctg aataataaca aaatataaaa 9600
accaataaaa atcataaaat agaaaatcaa caaaaatcat aaaatagaaa actagaaata 9660
gaagtaggta agaaggtata tgtgtcccct aagagacaca ccatatatag ctaagaatca 9720
atagataagc atagatcaaa gggctgaaca acccctgaat aataacaaaa tataaaaacc 9780
aataaaaatc ataaaataga aaaccacaaa tagaagtagt tcaaagggct ataaaacccc 9840
tgaatagtaa caaaatataa aactaataaa aatcaaacga ataccataat tggcaatcgg 9900
aagagatgta ggtacttaag cttcttaaaa gcagccgaac tcgctttgag atgtaggcgt 9960
agcacaccga actcttccat aattctccga acccacaggg acgtaggaga tgttcaaagt 10020
gactataaaa ccctgaacag taataaaata taaaattaat aatgagtacc ataattggca 10080
aatggaagag acgtaggtac taagcttctt aaaagcagcc gaactcactt tgagatgtag 10140
gcatagcata ccgaactctt ccacaattct ccgtacccat agggacgtag gagatgttat 10200
tttgttttta atatttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 10258
<210> 53
<211> 3137
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 53
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgtt 2700
caaagggcta taaaacccct gaatagtaac aaaatataaa actaataaaa atcaaacgaa 2760
taccataatt ggcaatcgga agagatgtag gtacttaagc ttcttaaaag cagccgaact 2820
cgctttgaga tgtaggcgta gcacaccgaa ctcttccata attctccgaa cccacaggga 2880
cgtaggagat gttcaaagtg actataaaac cctgaacagt aataaaatat aaaattaata 2940
atgagtacca taattggcaa atggaagaga cgtaggtact aagcttctta aaagcagccg 3000
aactcacttt gagatgtagg catagcatac cgaactcttc cacaattctc cgtacccata 3060
gggacgtagg agatgttatt ttgtttttaa tatttcaaaa aaaaaaaaaa aaaaaaaaaa 3120
aaaaaaaaaa aaaaaaa 3137
<210> 54
<211> 7168
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 54
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
caagaatagt tacagaaaaa cagaaacatt ctgttgtcat cacaacacac atatatcata 3060
aagctaaaca cacaaaagct tggtgtccta ggccccctag agctgtccct tacacacata 3120
gtcatgtgac taattatatg ccagaaacag gtgacgtgac aacagccata gtccgcagaa 3180
acactataac aactgctggg cccagtgatc tatatgtgca tgtaggtaac ttaatatata 3240
gaaacttaca tctgttcaat tctgaaatgc atgattcaat tttgatttca tactcttctg 3300
atttaatcat ataccgcaca aacactatag gtgatgatta tattcccaat tgtaactgca 3360
ctgaggctac ttattattgt agacacaaaa ataggtatta cccaataaaa gttactccac 3420
atgattggta tgaaatacaa gagagtgaat attaccccaa acacatccaa tacaacctat 3480
taattggtga aggaccatgt gaacctggtg attgtggtgg aaaacttctt tgtagacatg 3540
gtgtcattgg cataatcaca gcaggtggtg aaggtcatgt agcatttata gatcttagac 3600
aatttcactg tgctgaggaa caaggcataa ctgattacat acacatgttg ggagaggctt 3660
ttggcaatgg ttttgtagat agtgttaaag aacaaataaa tgcaataaat ccaatcaata 3720
acattagtaa gaaggttatt aagtggctac ttagaataat ctcggctatg gttattataa 3780
tcagaaactc ctctgaccct caaacgatca tagcaacctt gacactaatt ggttgcaatg 3840
gttcaccatg gagatttctc aaagaaaagt tttgcaaatg gacccaatta acttatatcc 3900
acaaagagtc tgattcatgg cttaagaaat tcactgaaat gtgtaatgct gcacgtggtc 3960
ttgaatggat tggtaataaa atttcaaaat ttatagattg gatgaaatct atgctacccc 4020
aggcccaatt gaaagttaaa tacttgaatg aaataaagaa actcagtttg cttgaaaaac 4080
agattgaaaa tctacgtgcg gcagatagtg caacacaaga gaaaatcaaa tgtgaaattg 4140
acaccctaca tgatctatcg tgcaaatttc ttcctttgta tgcacatgag gcaaaaagaa 4200
tcaaagtgct ttataataaa tgttccaata taattaaaca aagaaagaga agtgaaccgg 4260
tggcggtgat gatacatgga ccacccggta ctggtaaatc tataacaact aacttcttgg 4320
ctagaatgat aacaaatgaa agtgatgtgt actcattacc tccagatccc aaatattttg 4380
atggttatga caatcagagt gttgtaatca tggatgatat tatgcaaaat ccagatggag 4440
aagacatgac actattttgc caaatggttt caagtgttac atttatacca cccatggctg 4500
atttgcctga caagggtaaa ccatttgatt caagatttat cttatgtagt actaaccact 4560
cgcttttagc cccacctact atatcttcat tacccgcaat gaatagaaga tttttctttg 4620
acttagatat tgtagttcat gacaattata aagatacaca agggaaatta gatgtatcca 4680
aagcttttcg accttgtaat gttaacacca aaattggcaa tgcaagatgt tgtccatttg 4740
tatgtggtaa ggcagtgaca ttcaaagatc gcagcacttg ctcaacatac accttagctc 4800
aagtttacaa tcacattttg gaagaagaca aaagaaggag acaggtggtg gatgtcatgt 4860
ctgcaatttt ccaaggacca atttctttag acgctccacc accaccagct atagcagatc 4920
tgttacaatc agttagaaca cctgaggtaa tcaagtactg tcaagataat aaatggatca 4980
ttccagcaga gtgccaagtg gaaagagact taaatatagc cagtagcata atagctatta 5040
tagcaaatat aataagtata gctggcatta tacttgtaat ttataaattg ttttgttcat 5100
tacaaggacc atactcaggt gaacctaaac ctaaaaccaa agtacctgaa agaagagtag 5160
ttgctcaagg tccagaagaa gaatttggaa ggtcaattct caaaaacaat acttgtgtga 5220
ttactacagg taatggaaaa tttacaggtc ttggtataca tgacagaatt ctaatcatcc 5280
caacacatgc tgatccaggt agagaggtcc aagttaatgg tgtccacact aaggttctag 5340
actcatatga tctttataat agagatggag ttaaacttga aataacggtc atacaattag 5400
atagaaatga aaaatttagg gacattagaa agtatatacc tgaaacagaa gacgattatc 5460
cagaatgcaa tttggcactt tcagctaatc aagatgaacc aactataatt aaagtaggag 5520
atgtagtgtc ctatggcaat attttgctta gtggaaatca aacagccaga atgcttaaat 5580
ataattaccc cacaaaatct gggtattgtg gaggggtact atataaaatt ggtcaaattc 5640
taggtattca tgtgggtgga aatggaaggg atggtttttc agccatgtta cttagatcat 5700
actttacaga tactcagggc caaattaaag tcaataagca tgctactgaa tgtggtcttc 5760
caactataca cactcctagc aaaaccaaac ttcagcctag tgtattttat gatgtcttcc 5820
caggttctaa ggaaccagct gtgctcacag ataatgaccc tagattggaa gttaatttta 5880
aagaagcttt attttctaaa tataaaggta atgtggaatg taatttgaat gaacatatgg 5940
aaattgctat tgcccattac tcagcacaat taatgacact agatattgat tccaggccaa 6000
tagcattgga agatagcgtg tttggaatag aaggacttga ggctttagat ctaaacacca 6060
gtgcagggtt tccttatgtc acaatgggta ttaaaaagag agatttaata aataacaaaa 6120
caaaagatat atccaggctt aaagaggctc tagataaata tggagttgac ttacccatga 6180
tcactttctt aaaagacgag cttaggaaaa aggagaaaat ttcaacaggt aaaactagag 6240
ttatagaagc aagtagtata aatgacacaa tattatttag aactactttt ggcaatttgt 6300
tctctaagtt tcatttaaac ccaggcgttg ttactggctc tgcagtaggg tgtgaccctg 6360
agactttctg gtctaaaatc ccagttatgc ttgatggaga ttgtataatg gcttttgact 6420
atacaaatta tgatggtagt atacaccctg tctggtttca agctctgaaa aaagttcttg 6480
aaaatttatc tttccaatct aatttaattg atagattgtg ttattccaag cacttgttta 6540
aatcaacata ttatgaagtg gcaggtggag ttccttctgg gtgttctgga accagtatat 6600
tcaatactat gattaataac attataataa gaacactagt tctagatgca tacaaaaata 6660
ttgatctgga caagcttaaa ataattgcat atggtgatga tgtgattttc tcttataaat 6720
atactctaga tatggaagct attgctaatg aaggaaagaa atatggactt acaataacac 6780
cagcagataa gtccaatgaa ttcaagaaac ttgattatag taatgtgact tttcttaaac 6840
gtggttttaa gcaagatgaa agacatacat tccttattca tcctacattc ccagtggaag 6900
agatacatga atcaattaga tggaccaaga aaccttcaca gatgcaagaa catgtgctat 6960
cattatgtca cctgatgtgg cacaatggac gtaaggtgta tgaagatttc tctagtaaga 7020
tacgcagtgt cagcgctgga cgtgcactgt atatcccacc ttatgatctg ttgaaacatg 7080
aatggtatga aaaattttag atatagaaat aatgaatgaa tgattcttta attctataaa 7140
aaaaaaaaaa aaaaaaaaaa aaaaaaaa 7168
<210> 55
<211> 6973
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 55
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttatctc 1920
ttgttgtacc atgggtgagt gccagccact tcaggttaac tgcagataat aaatactcca 1980
tggctggtta tatcacatgt tggtaccaaa ctaatttagt agtgccccca agtacgccac 2040
agactgctga tatgctgtgt tttgtttctg catgtaaaga tttttgtcta cgaatggcaa 2100
gggatacaga tttacacata caaagtggtc caatagagca aaatccagta gaaaactaca 2160
ttgatgaagt tttaaatgaa gttttagtag tgccgaatat aaaagaaagt catcacacta 2220
catcaaactc tgccccactt ttagatgctg cagagacggg acacaccagt aatgttcaac 2280
cagaagatgc tatagagaca aggtatgtta taacatcaca aacaagagat gagatgagta 2340
tagaaagttt ccttggtaga tctggttgtg tccacatctc aagaataaag gttgattaca 2400
ctgactataa tggacaggac ataaatttca caaaatggaa aatcacacta caggaaatgg 2460
cacagattag gagaaaattt gaattgttta catatgtcag gtttgactca gaaataacct 2520
tggtgccttg tattgctggt agaggagacg acattggaca tattgtaatg caatatatgt 2580
atgttcctcc aggagctcca attccttcaa aaagaaacga tttctcatgg caatcaggca 2640
ccaatatgtc aatattctgg caacatggac agccatttcc tagattttct ttaccatttc 2700
ttagcattgc atcagcttat tatatgtttt atgatggata tgatggagac aacacttctt 2760
ccaagtatgg tagcgtagtt actaatgata tgggtactat atgctcaaga atagttacag 2820
aaaaacagaa acattctgtt gtcatcacaa cacacatata tcataaagct aaacacacaa 2880
aagcttggtg tcctaggccc cctagagctg tcccttacac acatagtcat gtgactaatt 2940
atatgccaga aacaggtgac gtgacaacag ccatagtccg cagaaacact ataacaactg 3000
ctgggcccag tgatctatat gtgcatgtag gtaacttaat atatagaaac ttacatctgt 3060
tcaattctga aatgcatgat tcaattttga tttcatactc ttctgattta atcatatacc 3120
gcacaaacac tataggtgat gattatattc ccaattgtaa ctgcactgag gctacttatt 3180
attgtagaca caaaaatagg tattacccaa taaaagttac tccacatgat tggtatgaaa 3240
tacaagagag tgaatattac cccaaacaca tccaatacaa cctattaatt ggtgaaggac 3300
catgtgaacc tggtgattgt ggtggaaaac ttctttgtag acatggtgtc attggcataa 3360
tcacagcagg tggtgaaggt catgtagcat ttatagatct tagacaattt cactgtgctg 3420
aggaacaagg cataactgat tacatacaca tgttgggaga ggcttttggc aatggttttg 3480
tagatagtgt taaagaacaa ataaatgcaa taaatccaat caataacatt agtaagaagg 3540
ttattaagtg gctacttaga ataatctcgg ctatggttat tataatcaga aactcctctg 3600
accctcaaac gatcatagca accttgacac taattggttg caatggttca ccatggagat 3660
ttctcaaaga aaagttttgc aaatggaccc aattaactta tatccacaaa gagtctgatt 3720
catggcttaa gaaattcact gaaatgtgta atgctgcacg tggtcttgaa tggattggta 3780
ataaaatttc aaaatttata gattggatga aatctatgct accccaggcc caattgaaag 3840
ttaaatactt gaatgaaata aagaaactca gtttgcttga aaaacagatt gaaaatctac 3900
gtgcggcaga tagtgcaaca caagagaaaa tcaaatgtga aattgacacc ctacatgatc 3960
tatcgtgcaa atttcttcct ttgtatgcac atgaggcaaa aagaatcaaa gtgctttata 4020
ataaatgttc caatataatt aaacaaagaa agagaagtga accggtggcg gtgatgatac 4080
atggaccacc cggtactggt aaatctataa caactaactt cttggctaga atgataacaa 4140
atgaaagtga tgtgtactca ttacctccag atcccaaata ttttgatggt tatgacaatc 4200
agagtgttgt aatcatggat gatattatgc aaaatccaga tggagaagac atgacactat 4260
tttgccaaat ggtttcaagt gttacattta taccacccat ggctgatttg cctgacaagg 4320
gtaaaccatt tgattcaaga tttatcttat gtagtactaa ccactcgctt ttagccccac 4380
ctactatatc ttcattaccc gcaatgaata gaagattttt ctttgactta gatattgtag 4440
ttcatgacaa ttataaagat acacaaggga aattagatgt atccaaagct tttcgacctt 4500
gtaatgttaa caccaaaatt ggcaatgcaa gatgttgtcc atttgtatgt ggtaaggcag 4560
tgacattcaa agatcgcagc acttgctcaa catacacctt agctcaagtt tacaatcaca 4620
ttttggaaga agacaaaaga aggagacagg tggtggatgt catgtctgca attttccaag 4680
gaccaatttc tttagacgct ccaccaccac cagctatagc agatctgtta caatcagtta 4740
gaacacctga ggtaatcaag tactgtcaag ataataaatg gatcattcca gcagagtgcc 4800
aagtggaaag agacttaaat atagccagta gcataatagc tattatagca aatataataa 4860
gtatagctgg cattatactt gtaatttata aattgttttg ttcattacaa ggaccatact 4920
caggtgaacc taaacctaaa accaaagtac ctgaaagaag agtagttgct caaggtccag 4980
aagaagaatt tggaaggtca attctcaaaa acaatacttg tgtgattact acaggtaatg 5040
gaaaatttac aggtcttggt atacatgaca gaattctaat catcccaaca catgctgatc 5100
caggtagaga ggtccaagtt aatggtgtcc acactaaggt tctagactca tatgatcttt 5160
ataatagaga tggagttaaa cttgaaataa cggtcataca attagataga aatgaaaaat 5220
ttagggacat tagaaagtat atacctgaaa cagaagacga ttatccagaa tgcaatttgg 5280
cactttcagc taatcaagat gaaccaacta taattaaagt aggagatgta gtgtcctatg 5340
gcaatatttt gcttagtgga aatcaaacag ccagaatgct taaatataat taccccacaa 5400
aatctgggta ttgtggaggg gtactatata aaattggtca aattctaggt attcatgtgg 5460
gtggaaatgg aagggatggt ttttcagcca tgttacttag atcatacttt acagatactc 5520
agggccaaat taaagtcaat aagcatgcta ctgaatgtgg tcttccaact atacacactc 5580
ctagcaaaac caaacttcag cctagtgtat tttatgatgt cttcccaggt tctaaggaac 5640
cagctgtgct cacagataat gaccctagat tggaagttaa ttttaaagaa gctttatttt 5700
ctaaatataa aggtaatgtg gaatgtaatt tgaatgaaca tatggaaatt gctattgccc 5760
attactcagc acaattaatg acactagata ttgattccag gccaatagca ttggaagata 5820
gcgtgtttgg aatagaagga cttgaggctt tagatctaaa caccagtgca gggtttcctt 5880
atgtcacaat gggtattaaa aagagagatt taataaataa caaaacaaaa gatatatcca 5940
ggcttaaaga ggctctagat aaatatggag ttgacttacc catgatcact ttcttaaaag 6000
acgagcttag gaaaaaggag aaaatttcaa caggtaaaac tagagttata gaagcaagta 6060
gtataaatga cacaatatta tttagaacta cttttggcaa tttgttctct aagtttcatt 6120
taaacccagg cgttgttact ggctctgcag tagggtgtga ccctgagact ttctggtcta 6180
aaatcccagt tatgcttgat ggagattgta taatggcttt tgactataca aattatgatg 6240
gtagtataca ccctgtctgg tttcaagctc tgaaaaaagt tcttgaaaat ttatctttcc 6300
aatctaattt aattgataga ttgtgttatt ccaagcactt gtttaaatca acatattatg 6360
aagtggcagg tggagttcct tctgggtgtt ctggaaccag tatattcaat actatgatta 6420
ataacattat aataagaaca ctagttctag atgcatacaa aaatattgat ctggacaagc 6480
ttaaaataat tgcatatggt gatgatgtga ttttctctta taaatatact ctagatatgg 6540
aagctattgc taatgaagga aagaaatatg gacttacaat aacaccagca gataagtcca 6600
atgaattcaa gaaacttgat tatagtaatg tgacttttct taaacgtggt tttaagcaag 6660
atgaaagaca tacattcctt attcatccta cattcccagt ggaagagata catgaatcaa 6720
ttagatggac caagaaacct tcacagatgc aagaacatgt gctatcatta tgtcacctga 6780
tgtggcacaa tggacgtaag gtgtatgaag atttctctag taagatacgc agtgtcagcg 6840
ctggacgtgc actgtatatc ccaccttatg atctgttgaa acatgaatgg tatgaaaaat 6900
tttagatata gaaataatga atgaatgatt ctttaattct ataaaaaaaa aaaaaaaaaa 6960
aaaaaaaaaa aaa 6973
<210> 56
<211> 6972
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 56
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca acttatctct 1920
tgttgtacca tgggtgagtg ccagccactt caggttaact gcagataata aatactccat 1980
ggctggttat atcacatgtt ggtaccaaac taatttagta gtgcccccaa gtacgccaca 2040
gactgctgat atgctgtgtt ttgtttctgc atgtaaagat ttttgtctac gaatggcaag 2100
ggatacagat ttacacatac aaagtggtcc aatagagcaa aatccagtag aaaactacat 2160
tgatgaagtt ttaaatgaag ttttagtagt gccgaatata aaagaaagtc atcacactac 2220
atcaaactct gccccacttt tagatgctgc agagacggga cacaccagta atgttcaacc 2280
agaagatgct atagagacaa ggtatgttat aacatcacaa acaagagatg agatgagtat 2340
agaaagtttc cttggtagat ctggttgtgt ccacatctca agaataaagg ttgattacac 2400
tgactataat ggacaggaca taaatttcac aaaatggaaa atcacactac aggaaatggc 2460
acagattagg agaaaatttg aattgtttac atatgtcagg tttgactcag aaataacctt 2520
ggtgccttgt attgctggta gaggagacga cattggacat attgtaatgc aatatatgta 2580
tgttcctcca ggagctccaa ttccttcaaa aagaaacgat ttctcatggc aatcaggcac 2640
caatatgtca atattctggc aacatggaca gccatttcct agattttctt taccatttct 2700
tagcattgca tcagcttatt atatgtttta tgatggatat gatggagaca acacttcttc 2760
caagtatggt agcgtagtta ctaatgatat gggtactata tgctcaagaa tagttacaga 2820
aaaacagaaa cattctgttg tcatcacaac acacatatat cataaagcta aacacacaaa 2880
agcttggtgt cctaggcccc ctagagctgt cccttacaca catagtcatg tgactaatta 2940
tatgccagaa acaggtgacg tgacaacagc catagtccgc agaaacacta taacaactgc 3000
tgggcccagt gatctatatg tgcatgtagg taacttaata tatagaaact tacatctgtt 3060
caattctgaa atgcatgatt caattttgat ttcatactct tctgatttaa tcatataccg 3120
cacaaacact ataggtgatg attatattcc caattgtaac tgcactgagg ctacttatta 3180
ttgtagacac aaaaataggt attacccaat aaaagttact ccacatgatt ggtatgaaat 3240
acaagagagt gaatattacc ccaaacacat ccaatacaac ctattaattg gtgaaggacc 3300
atgtgaacct ggtgattgtg gtggaaaact tctttgtaga catggtgtca ttggcataat 3360
cacagcaggt ggtgaaggtc atgtagcatt tatagatctt agacaatttc actgtgctga 3420
ggaacaaggc ataactgatt acatacacat gttgggagag gcttttggca atggttttgt 3480
agatagtgtt aaagaacaaa taaatgcaat aaatccaatc aataacatta gtaagaaggt 3540
tattaagtgg ctacttagaa taatctcggc tatggttatt ataatcagaa actcctctga 3600
ccctcaaacg atcatagcaa ccttgacact aattggttgc aatggttcac catggagatt 3660
tctcaaagaa aagttttgca aatggaccca attaacttat atccacaaag agtctgattc 3720
atggcttaag aaattcactg aaatgtgtaa tgctgcacgt ggtcttgaat ggattggtaa 3780
taaaatttca aaatttatag attggatgaa atctatgcta ccccaggccc aattgaaagt 3840
taaatacttg aatgaaataa agaaactcag tttgcttgaa aaacagattg aaaatctacg 3900
tgcggcagat agtgcaacac aagagaaaat caaatgtgaa attgacaccc tacatgatct 3960
atcgtgcaaa tttcttcctt tgtatgcaca tgaggcaaaa agaatcaaag tgctttataa 4020
taaatgttcc aatataatta aacaaagaaa gagaagtgaa ccggtggcgg tgatgataca 4080
tggaccaccc ggtactggta aatctataac aactaacttc ttggctagaa tgataacaaa 4140
tgaaagtgat gtgtactcat tacctccaga tcccaaatat tttgatggtt atgacaatca 4200
gagtgttgta atcatggatg atattatgca aaatccagat ggagaagaca tgacactatt 4260
ttgccaaatg gtttcaagtg ttacatttat accacccatg gctgatttgc ctgacaaggg 4320
taaaccattt gattcaagat ttatcttatg tagtactaac cactcgcttt tagccccacc 4380
tactatatct tcattacccg caatgaatag aagatttttc tttgacttag atattgtagt 4440
tcatgacaat tataaagata cacaagggaa attagatgta tccaaagctt ttcgaccttg 4500
taatgttaac accaaaattg gcaatgcaag atgttgtcca tttgtatgtg gtaaggcagt 4560
gacattcaaa gatcgcagca cttgctcaac atacacctta gctcaagttt acaatcacat 4620
tttggaagaa gacaaaagaa ggagacaggt ggtggatgtc atgtctgcaa ttttccaagg 4680
accaatttct ttagacgctc caccaccacc agctatagca gatctgttac aatcagttag 4740
aacacctgag gtaatcaagt actgtcaaga taataaatgg atcattccag cagagtgcca 4800
agtggaaaga gacttaaata tagccagtag cataatagct attatagcaa atataataag 4860
tatagctggc attatacttg taatttataa attgttttgt tcattacaag gaccatactc 4920
aggtgaacct aaacctaaaa ccaaagtacc tgaaagaaga gtagttgctc aaggtccaga 4980
agaagaattt ggaaggtcaa ttctcaaaaa caatacttgt gtgattacta caggtaatgg 5040
aaaatttaca ggtcttggta tacatgacag aattctaatc atcccaacac atgctgatcc 5100
aggtagagag gtccaagtta atggtgtcca cactaaggtt ctagactcat atgatcttta 5160
taatagagat ggagttaaac ttgaaataac ggtcatacaa ttagatagaa atgaaaaatt 5220
tagggacatt agaaagtata tacctgaaac agaagacgat tatccagaat gcaatttggc 5280
actttcagct aatcaagatg aaccaactat aattaaagta ggagatgtag tgtcctatgg 5340
caatattttg cttagtggaa atcaaacagc cagaatgctt aaatataatt accccacaaa 5400
atctgggtat tgtggagggg tactatataa aattggtcaa attctaggta ttcatgtggg 5460
tggaaatgga agggatggtt tttcagccat gttacttaga tcatacttta cagatactca 5520
gggccaaatt aaagtcaata agcatgctac tgaatgtggt cttccaacta tacacactcc 5580
tagcaaaacc aaacttcagc ctagtgtatt ttatgatgtc ttcccaggtt ctaaggaacc 5640
agctgtgctc acagataatg accctagatt ggaagttaat tttaaagaag ctttattttc 5700
taaatataaa ggtaatgtgg aatgtaattt gaatgaacat atggaaattg ctattgccca 5760
ttactcagca caattaatga cactagatat tgattccagg ccaatagcat tggaagatag 5820
cgtgtttgga atagaaggac ttgaggcttt agatctaaac accagtgcag ggtttcctta 5880
tgtcacaatg ggtattaaaa agagagattt aataaataac aaaacaaaag atatatccag 5940
gcttaaagag gctctagata aatatggagt tgacttaccc atgatcactt tcttaaaaga 6000
cgagcttagg aaaaaggaga aaatttcaac aggtaaaact agagttatag aagcaagtag 6060
tataaatgac acaatattat ttagaactac ttttggcaat ttgttctcta agtttcattt 6120
aaacccaggc gttgttactg gctctgcagt agggtgtgac cctgagactt tctggtctaa 6180
aatcccagtt atgcttgatg gagattgtat aatggctttt gactatacaa attatgatgg 6240
tagtatacac cctgtctggt ttcaagctct gaaaaaagtt cttgaaaatt tatctttcca 6300
atctaattta attgatagat tgtgttattc caagcacttg tttaaatcaa catattatga 6360
agtggcaggt ggagttcctt ctgggtgttc tggaaccagt atattcaata ctatgattaa 6420
taacattata ataagaacac tagttctaga tgcatacaaa aatattgatc tggacaagct 6480
taaaataatt gcatatggtg atgatgtgat tttctcttat aaatatactc tagatatgga 6540
agctattgct aatgaaggaa agaaatatgg acttacaata acaccagcag ataagtccaa 6600
tgaattcaag aaacttgatt atagtaatgt gacttttctt aaacgtggtt ttaagcaaga 6660
tgaaagacat acattcctta ttcatcctac attcccagtg gaagagatac atgaatcaat 6720
tagatggacc aagaaacctt cacagatgca agaacatgtg ctatcattat gtcacctgat 6780
gtggcacaat ggacgtaagg tgtatgaaga tttctctagt aagatacgca gtgtcagcgc 6840
tggacgtgca ctgtatatcc caccttatga tctgttgaaa catgaatggt atgaaaaatt 6900
ttagatatag aaataatgaa tgaatgattc tttaattcta taaaaaaaaa aaaaaaaaaa 6960
aaaaaaaaaa aa 6972
<210> 57
<211> 6931
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 57
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
ctagaaactt acatctgttc aattctgaaa tgcatgattc aattttgatt tcatactctt 3060
ctgatttaat catataccgc acaaacacta taggtgatga ttatattccc aattgtaact 3120
gcactgaggc tacttattat tgtagacaca aaaataggta ttacccaata aaagttactc 3180
cacatgattg gtatgaaata caagagagtg aatattaccc caaacacatc caatacaacc 3240
tattaattgg tgaaggacca tgtgaacctg gtgattgtgg tggaaaactt ctttgtagac 3300
atggtgtcat tggcataatc acagcaggtg gtgaaggtca tgtagcattt atagatctta 3360
gacaatttca ctgtgctgag gaacaaggca taactgatta catacacatg ttgggagagg 3420
cttttggcaa tggttttgta gatagtgtta aagaacaaat aaatgcaata aatccaatca 3480
ataacattag taagaaggtt attaagtggc tacttagaat aatctcggct atggttatta 3540
taatcagaaa ctcctctgac cctcaaacga tcatagcaac cttgacacta attggttgca 3600
atggttcacc atggagattt ctcaaagaaa agttttgcaa atggacccaa ttaacttata 3660
tccacaaaga gtctgattca tggcttaaga aattcactga aatgtgtaat gctgcacgtg 3720
gtcttgaatg gattggtaat aaaatttcaa aatttataga ttggatgaaa tctatgctac 3780
cccaggccca attgaaagtt aaatacttga atgaaataaa gaaactcagt ttgcttgaaa 3840
aacagattga aaatctacgt gcggcagata gtgcaacaca agagaaaatc aaatgtgaaa 3900
ttgacaccct acatgatcta tcgtgcaaat ttcttccttt gtatgcacat gaggcaaaaa 3960
gaatcaaagt gctttataat aaatgttcca atataattaa acaaagaaag agaagtgaac 4020
cggtggcggt gatgatacat ggaccacccg gtactggtaa atctataaca actaacttct 4080
tggctagaat gataacaaat gaaagtgatg tgtactcatt acctccagat cccaaatatt 4140
ttgatggtta tgacaatcag agtgttgtaa tcatggatga tattatgcaa aatccagatg 4200
gagaagacat gacactattt tgccaaatgg tttcaagtgt tacatttata ccacccatgg 4260
ctgatttgcc tgacaagggt aaaccatttg attcaagatt tatcttatgt agtactaacc 4320
actcgctttt agccccacct actatatctt cattacccgc aatgaataga agatttttct 4380
ttgacttaga tattgtagtt catgacaatt ataaagatac acaagggaaa ttagatgtat 4440
ccaaagcttt tcgaccttgt aatgttaaca ccaaaattgg caatgcaaga tgttgtccat 4500
ttgtatgtgg taaggcagtg acattcaaag atcgcagcac ttgctcaaca tacaccttag 4560
ctcaagttta caatcacatt ttggaagaag acaaaagaag gagacaggtg gtggatgtca 4620
tgtctgcaat tttccaagga ccaatttctt tagacgctcc accaccacca gctatagcag 4680
atctgttaca atcagttaga acacctgagg taatcaagta ctgtcaagat aataaatgga 4740
tcattccagc agagtgccaa gtggaaagag acttaaatat agccagtagc ataatagcta 4800
ttatagcaaa tataataagt atagctggca ttatacttgt aatttataaa ttgttttgtt 4860
cattacaagg accatactca ggtgaaccta aacctaaaac caaagtacct gaaagaagag 4920
tagttgctca aggtccagaa gaagaatttg gaaggtcaat tctcaaaaac aatacttgtg 4980
tgattactac aggtaatgga aaatttacag gtcttggtat acatgacaga attctaatca 5040
tcccaacaca tgctgatcca ggtagagagg tccaagttaa tggtgtccac actaaggttc 5100
tagactcata tgatctttat aatagagatg gagttaaact tgaaataacg gtcatacaat 5160
tagatagaaa tgaaaaattt agggacatta gaaagtatat acctgaaaca gaagacgatt 5220
atccagaatg caatttggca ctttcagcta atcaagatga accaactata attaaagtag 5280
gagatgtagt gtcctatggc aatattttgc ttagtggaaa tcaaacagcc agaatgctta 5340
aatataatta ccccacaaaa tctgggtatt gtggaggggt actatataaa attggtcaaa 5400
ttctaggtat tcatgtgggt ggaaatggaa gggatggttt ttcagccatg ttacttagat 5460
catactttac agatactcag ggccaaatta aagtcaataa gcatgctact gaatgtggtc 5520
ttccaactat acacactcct agcaaaacca aacttcagcc tagtgtattt tatgatgtct 5580
tcccaggttc taaggaacca gctgtgctca cagataatga ccctagattg gaagttaatt 5640
ttaaagaagc tttattttct aaatataaag gtaatgtgga atgtaatttg aatgaacata 5700
tggaaattgc tattgcccat tactcagcac aattaatgac actagatatt gattccaggc 5760
caatagcatt ggaagatagc gtgtttggaa tagaaggact tgaggcttta gatctaaaca 5820
ccagtgcagg gtttccttat gtcacaatgg gtattaaaaa gagagattta ataaataaca 5880
aaacaaaaga tatatccagg cttaaagagg ctctagataa atatggagtt gacttaccca 5940
tgatcacttt cttaaaagac gagcttagga aaaaggagaa aatttcaaca ggtaaaacta 6000
gagttataga agcaagtagt ataaatgaca caatattatt tagaactact tttggcaatt 6060
tgttctctaa gtttcattta aacccaggcg ttgttactgg ctctgcagta gggtgtgacc 6120
ctgagacttt ctggtctaaa atcccagtta tgcttgatgg agattgtata atggcttttg 6180
actatacaaa ttatgatggt agtatacacc ctgtctggtt tcaagctctg aaaaaagttc 6240
ttgaaaattt atctttccaa tctaatttaa ttgatagatt gtgttattcc aagcacttgt 6300
ttaaatcaac atattatgaa gtggcaggtg gagttccttc tgggtgttct ggaaccagta 6360
tattcaatac tatgattaat aacattataa taagaacact agttctagat gcatacaaaa 6420
atattgatct ggacaagctt aaaataattg catatggtga tgatgtgatt ttctcttata 6480
aatatactct agatatggaa gctattgcta atgaaggaaa gaaatatgga cttacaataa 6540
caccagcaga taagtccaat gaattcaaga aacttgatta tagtaatgtg acttttctta 6600
aacgtggttt taagcaagat gaaagacata cattccttat tcatcctaca ttcccagtgg 6660
aagagataca tgaatcaatt agatggacca agaaaccttc acagatgcaa gaacatgtgc 6720
tatcattatg tcacctgatg tggcacaatg gacgtaaggt gtatgaagat ttctctagta 6780
agatacgcag tgtcagcgct ggacgtgcac tgtatatccc accttatgat ctgttgaaac 6840
atgaatggta tgaaaaattt tagatataga aataatgaat gaatgattct ttaattctat 6900
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 6931
<210> 58
<211> 7087
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 58
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
caagaatagt tacagaaaaa cagaaacatt ctgttgtcat cacaacacac atatatcata 3060
aagctaaaca cacaaaagct tggtgtccta ggccccctag agctgtccct tacacacata 3120
gtcatgtgac taattatatg ccagaaacag gtgacgtgac aacagccata gtccgcagaa 3180
acactataac aactgctggg cccagtgatc tatatgtgca tgtaggtaac ttaatatata 3240
gaaacttaca tctgttcaat tctgaaatgc atgattcaat tttgatttca tactcttctg 3300
atttaatcat ataccgcaca aacactatag gtgatgatta tattcccaat tgtaactgca 3360
ctgaggctac ttattattgt agacacaaaa ataggtatta cccaataaaa gttactccac 3420
atgattggta tgaaatacaa gagagtgaat attaccccaa acacatccaa tacaacctat 3480
taattggtga aggtcatgta gcatttatag atcttagaca atttcactgt gctgaggaac 3540
aaggcataac tgattacata cacatgttgg gagaggcttt tggcaatggt tttgtagata 3600
gtgttaaaga acaaataaat gcaataaatc caatcaataa cattagtaag aaggttatta 3660
agtggctact tagaataatc tcggctatgg ttattataat cagaaactcc tctgaccctc 3720
aaacgatcat agcaaccttg acactaattg gttgcaatgg ttcaccatgg agatttctca 3780
aagaaaagtt ttgcaaatgg acccaattaa cttatatcca caaagagtct gattcatggc 3840
ttaagaaatt cactgaaatg tgtaatgctg cacgtggtct tgaatggatt ggtaataaaa 3900
tttcaaaatt tatagattgg atgaaatcta tgctacccca ggcccaattg aaagttaaat 3960
acttgaatga aataaagaaa ctcagtttgc ttgaaaaaca gattgaaaat ctacgtgcgg 4020
cagatagtgc aacacaagag aaaatcaaat gtgaaattga caccctacat gatctatcgt 4080
gcaaatttct tcctttgtat gcacatgagg caaaaagaat caaagtgctt tataataaat 4140
gttccaatat aattaaacaa agaaagagaa gtgaaccggt ggcggtgatg atacatggac 4200
cacccggtac tggtaaatct ataacaacta acttcttggc tagaatgata acaaatgaaa 4260
gtgatgtgta ctcattacct ccagatccca aatattttga tggttatgac aatcagagtg 4320
ttgtaatcat ggatgatatt atgcaaaatc cagatggaga agacatgaca ctattttgcc 4380
aaatggtttc aagtgttaca tttataccac ccatggctga tttgcctgac aagggtaaac 4440
catttgattc aagatttatc ttatgtagta ctaaccactc gcttttagcc ccacctacta 4500
tatcttcatt acccgcaatg aatagaagat ttttctttga cttagatatt gtagttcatg 4560
acaattataa agatacacaa gggaaattag atgtatccaa agcttttcga ccttgtaatg 4620
ttaacaccaa aattggcaat gcaagatgtt gtccatttgt atgtggtaag gcagtgacat 4680
tcaaagatcg cagcacttgc tcaacataca ccttagctca agtttacaat cacattttgg 4740
aagaagacaa aagaaggaga caggtggtgg atgtcatgtc tgcaattttc caaggaccaa 4800
tttctttaga cgctccacca ccaccagcta tagcagatct gttacaatca gttagaacac 4860
ctgaggtaat caagtactgt caagataata aatggatcat tccagcagag tgccaagtgg 4920
aaagagactt aaatatagcc agtagcataa tagctattat agcaaatata ataagtatag 4980
ctggcattat acttgtaatt tataaattgt tttgttcatt acaaggacca tactcaggtg 5040
aacctaaacc taaaaccaaa gtacctgaaa gaagagtagt tgctcaaggt ccagaagaag 5100
aatttggaag gtcaattctc aaaaacaata cttgtgtgat tactacaggt aatggaaaat 5160
ttacaggtct tggtatacat gacagaattc taatcatccc aacacatgct gatccaggta 5220
gagaggtcca agttaatggt gtccacacta aggttctaga ctcatatgat ctttataata 5280
gagatggagt taaacttgaa ataacggtca tacaattaga tagaaatgaa aaatttaggg 5340
acattagaaa gtatatacct gaaacagaag acgattatcc agaatgcaat ttggcacttt 5400
cagctaatca agatgaacca actataatta aagtaggaga tgtagtgtcc tatggcaata 5460
ttttgcttag tggaaatcaa acagccagaa tgcttaaata taattacccc acaaaatctg 5520
ggtattgtgg aggggtacta tataaaattg gtcaaattct aggtattcat gtgggtggaa 5580
atggaaggga tggtttttca gccatgttac ttagatcata ctttacagat actcagggcc 5640
aaattaaagt caataagcat gctactgaat gtggtcttcc aactatacac actcctagca 5700
aaaccaaact tcagcctagt gtattttatg atgtcttccc aggttctaag gaaccagctg 5760
tgctcacaga taatgaccct agattggaag ttaattttaa agaagcttta ttttctaaat 5820
ataaaggtaa tgtggaatgt aatttgaatg aacatatgga aattgctatt gcccattact 5880
cagcacaatt aatgacacta gatattgatt ccaggccaat agcattggaa gatagcgtgt 5940
ttggaataga aggacttgag gctttagatc taaacaccag tgcagggttt ccttatgtca 6000
caatgggtat taaaaagaga gatttaataa ataacaaaac aaaagatata tccaggctta 6060
aagaggctct agataaatat ggagttgact tacccatgat cactttctta aaagacgagc 6120
ttaggaaaaa ggagaaaatt tcaacaggta aaactagagt tatagaagca agtagtataa 6180
atgacacaat attatttaga actacttttg gcaatttgtt ctctaagttt catttaaacc 6240
caggcgttgt tactggctct gcagtagggt gtgaccctga gactttctgg tctaaaatcc 6300
cagttatgct tgatggagat tgtataatgg cttttgacta tacaaattat gatggtagta 6360
tacaccctgt ctggtttcaa gctctgaaaa aagttcttga aaatttatct ttccaatcta 6420
atttaattga tagattgtgt tattccaagc acttgtttaa atcaacatat tatgaagtgg 6480
caggtggagt tccttctggg tgttctggaa ccagtatatt caatactatg attaataaca 6540
ttataataag aacactagtt ctagatgcat acaaaaatat tgatctggac aagcttaaaa 6600
taattgcata tggtgatgat gtgattttct cttataaata tactctagat atggaagcta 6660
ttgctaatga aggaaagaaa tatggactta caataacacc agcagataag tccaatgaat 6720
tcaagaaact tgattatagt aatgtgactt ttcttaaacg tggttttaag caagatgaaa 6780
gacatacatt ccttattcat cctacattcc cagtggaaga gatacatgaa tcaattagat 6840
ggaccaagaa accttcacag atgcaagaac atgtgctatc attatgtcac ctgatgtggc 6900
acaatggacg taaggtgtat gaagatttct ctagtaagat acgcagtgtc agcgctggac 6960
gtgcactgta tatcccacct tatgatctgt tgaaacatga atggtatgaa aaattttaga 7020
tatagaaata atgaatgaat gattctttaa ttctataaaa aaaaaaaaaa aaaaaaaaaa 7080
aaaaaaa 7087
<210> 59
<211> 7087
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 59
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
caagaatagt tacagaaaaa cagaaacatt ctgttgtcat cacaacacac atatatcata 3060
aagctaaaca cacaaaagct tggtgtccta ggccccctag agctgtccct tacacacata 3120
gtcatgtgac taattatatg ccagaaacag gtgacgtgac aacagccata gtccgcagaa 3180
acactataac aactgctggg cccagtgatc tatatgtgca tgtaggtaac ttaatatata 3240
gaaacttaca tctgttcaat tctgaaatgc atgattcaat tttgatttca tactcttctg 3300
atttaatcat ataccgcaca aacactatag gtgatgatta tattcccaat tgtaactgca 3360
ctgaggctac ttattattgt agacacaaaa ataggtatta cccaataaaa gttactccac 3420
atgattggta tgaaatacaa gagagtgaat attaccccaa acacatccaa tacaacctat 3480
taattggtga aggaccatgt gaacctggtg attgtggtgg aaaacttctt tgtagacatg 3540
gtgtcattgg cataatcaca gcaggtggtg aaggtcatgt agcatttata gatcttagac 3600
aatttcactg tgctgaggaa caaggcataa ctgattacat acacatgttg ggagaggctt 3660
ttggcaatgg ttttgtagat agtgttaaag aacaaataaa tgcaataaat ccaatcaata 3720
acattagtaa gaaggttatt aagtggctac ttagaataat ctcggctatg gttattataa 3780
tcagaaactc ctctgaccct caaacgatca tagcaacctt gacactaatt ggttgcaatg 3840
gttcaccatg gagatttctc aaagaaaagt tttgcaaatg gacccaatta acttatatcc 3900
acaaagagtc tgattcatgg cttaagaaat tcactgaaat gtgtaatgct gcacgtggtc 3960
ttgaatggat tggtaataaa atttcaaaat ttatagattg gatgaaatct atgctacccc 4020
aggcccaatt gaaagttaaa tacttgaatg aaataaagaa actcagtttg cttgaaaaac 4080
agattgaaaa tctacgtgcg gcagatagtg caacacaaga gaaaatcaaa tgtgaaattg 4140
acaccctaca tgatctatcg tgcaaatttc ttcctttgta tgcacatgag gcaaaaagaa 4200
tcaaagtgct ttataataaa tgttccaata taattaaaca aagaaagaga agtgaaccgg 4260
tggcggtgat gatacatgga ccacccggta ctggtaaatc tataacaact aacttcttgg 4320
ctagaatgat aacaaatgaa agtgatgtgt actcattacc tccagatccc aaatattttg 4380
atggttatga caatcagagt gttgtaatca tggatgatat tatgcaaaat ccagatggag 4440
aagacatgac actattttgc caaatggttt caagtgttac atttatacca cccatggctg 4500
atttgcctga caagggtaaa ccatttgatt caagatttat cttatgtagt actaaccact 4560
cgcttttagc cccacctact atatcttcat tacccgcaat gaatagaaga tttttctttg 4620
acttagatat tgtagttcat gacaattata aagatacaca agggaaatta gatgtatcca 4680
aagcttttcg accttgtaat gttaacacca aaattggcaa tgcaagatgt tgtccatttg 4740
tatgtggtaa ggcagtgaca ttcaaagatc gcagcacttg ctcaacatac accttagctc 4800
aagtttacaa tcacattttg gaagaagaca aaagaaggag acaggtggtg gatgtcatgt 4860
ctgcaatttt ccaaggacca atttctttag acgctccacc accaccagct atagcagatc 4920
tgttacaatc agttagaaca cctgaggtaa tcaagtactg tcaagataat aaatggatca 4980
ttccagcaga gtgccaagtg gataaattgt tttgttcatt acaaggacca tactcaggtg 5040
aacctaaacc taaaaccaaa gtacctgaaa gaagagtagt tgctcaaggt ccagaagaag 5100
aatttggaag gtcaattctc aaaaacaata cttgtgtgat tactacaggt aatggaaaat 5160
ttacaggtct tggtatacat gacagaattc taatcatccc aacacatgct gatccaggta 5220
gagaggtcca agttaatggt gtccacacta aggttctaga ctcatatgat ctttataata 5280
gagatggagt taaacttgaa ataacggtca tacaattaga tagaaatgaa aaatttaggg 5340
acattagaaa gtatatacct gaaacagaag acgattatcc agaatgcaat ttggcacttt 5400
cagctaatca agatgaacca actataatta aagtaggaga tgtagtgtcc tatggcaata 5460
ttttgcttag tggaaatcaa acagccagaa tgcttaaata taattacccc acaaaatctg 5520
ggtattgtgg aggggtacta tataaaattg gtcaaattct aggtattcat gtgggtggaa 5580
atggaaggga tggtttttca gccatgttac ttagatcata ctttacagat actcagggcc 5640
aaattaaagt caataagcat gctactgaat gtggtcttcc aactatacac actcctagca 5700
aaaccaaact tcagcctagt gtattttatg atgtcttccc aggttctaag gaaccagctg 5760
tgctcacaga taatgaccct agattggaag ttaattttaa agaagcttta ttttctaaat 5820
ataaaggtaa tgtggaatgt aatttgaatg aacatatgga aattgctatt gcccattact 5880
cagcacaatt aatgacacta gatattgatt ccaggccaat agcattggaa gatagcgtgt 5940
ttggaataga aggacttgag gctttagatc taaacaccag tgcagggttt ccttatgtca 6000
caatgggtat taaaaagaga gatttaataa ataacaaaac aaaagatata tccaggctta 6060
aagaggctct agataaatat ggagttgact tacccatgat cactttctta aaagacgagc 6120
ttaggaaaaa ggagaaaatt tcaacaggta aaactagagt tatagaagca agtagtataa 6180
atgacacaat attatttaga actacttttg gcaatttgtt ctctaagttt catttaaacc 6240
caggcgttgt tactggctct gcagtagggt gtgaccctga gactttctgg tctaaaatcc 6300
cagttatgct tgatggagat tgtataatgg cttttgacta tacaaattat gatggtagta 6360
tacaccctgt ctggtttcaa gctctgaaaa aagttcttga aaatttatct ttccaatcta 6420
atttaattga tagattgtgt tattccaagc acttgtttaa atcaacatat tatgaagtgg 6480
caggtggagt tccttctggg tgttctggaa ccagtatatt caatactatg attaataaca 6540
ttataataag aacactagtt ctagatgcat acaaaaatat tgatctggac aagcttaaaa 6600
taattgcata tggtgatgat gtgattttct cttataaata tactctagat atggaagcta 6660
ttgctaatga aggaaagaaa tatggactta caataacacc agcagataag tccaatgaat 6720
tcaagaaact tgattatagt aatgtgactt ttcttaaacg tggttttaag caagatgaaa 6780
gacatacatt ccttattcat cctacattcc cagtggaaga gatacatgaa tcaattagat 6840
ggaccaagaa accttcacag atgcaagaac atgtgctatc attatgtcac ctgatgtggc 6900
acaatggacg taaggtgtat gaagatttct ctagtaagat acgcagtgtc agcgctggac 6960
gtgcactgta tatcccacct tatgatctgt tgaaacatga atggtatgaa aaattttaga 7020
tatagaaata atgaatgaat gattctttaa ttctataaaa aaaaaaaaaa aaaaaaaaaa 7080
aaaaaaa 7087
<210> 60
<211> 7156
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 60
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
caagaatagt tacagaaaaa cagaaacatt ctgttgtcat cacaacacac atatatcata 3060
aagctaaaca cacaaaagct tggtgtccta ggccccctag agctgtccct tacacacata 3120
gtcatgtgac taattatatg ccagaaacag gtgacgtgac aacagccata gtccgcagaa 3180
acactataac aactgctggg cccagtgatc tatatgtgca tgtaggtaac ttaatatata 3240
gaaacttaca tctgttcaat tctgaaatgc atgattcaat tttgatttca tactcttctg 3300
atttaatcat ataccgcaca aacactatag gtgatgatta tattcccaat tgtaactgca 3360
ctgaggctac ttattattgt agacacaaaa ataggtatta cccaataaaa gttactccac 3420
atgattggta tgaaatacaa gagagtgaat attaccccaa acacatccaa tacaacctat 3480
taattggtga aggaccatgt gaacctggtg attgtggtgg aaaacttctt tgtagacatg 3540
gtgtcattgg cataatcaca gcaggtggtg aaggtcatgt agcatttata gatcttagac 3600
aatttcactg tgctgaggaa caaggcataa ctgattacat acacatgttg ggagaggctt 3660
ttggcaatgg ttttgtagat agtgttaaag aacaaataaa tgcaataaat ccaatcaata 3720
acattagtaa gaaggttatt aagtggctac ttagaataat ctcggctatg gttattataa 3780
tcagaaactc ctctgaccct caaacgatca tagcaacctt gacactaatt ggttgcaatg 3840
gttcaccatg gagatttctc aaagaaaagt tttgcaaatg gacccaatta acttatatcc 3900
acaaagagtc tgattcatgg cttaagaaat tcactgaaat gtgtaatgct gcacgtggtc 3960
ttgaatggat tggtaataaa atttcaaaat ttatagattg gatgaaatct atgctacccc 4020
aggcccaatt gaaagttaaa tacttgaatg aaataaagaa actcagtttg cttgaaaaac 4080
agattgaaaa tctacgtgcg gcagatagtg caacacaaga gaaaatcaaa tgtgaaattg 4140
acaccctaca tgatctatcg tgcaaatttc ttcctttgta tgcacatgag gcaaaaagaa 4200
tcaaagtgct ttataataaa tgttccaata taattaaaca aagaaagaga agtgaaccgg 4260
tggcggtgat gatacatgga ccacccggta ctggtaaatc tataacaact aacttcttgg 4320
ctagaatgat aacaaatgaa agtgatgtgt actcattacc tccagatccc aaatattttg 4380
atggttatga caatcagagt gttgtaatca tggatgatat tatgcaaaat ccagatggag 4440
aagacatgac actattttgc caaatggttt caagtgttac atttatacca cccatggctg 4500
atttgcctga caagggtaaa ccatttgatt caagatttat cttatgtagt actaaccact 4560
cgcttttagc cccacctact atatcttcat tacccgcaat gaatagaaga tttttctttg 4620
acttagatat tgtagttcat gacaattata aagatacaca agggaaatta gatgtatcca 4680
aagcttttcg accttgtaat gttaacacca aaattggcaa tgcaagatgt tgtccatttg 4740
tatgtggtaa ggcagtgaca ttcaaagatc gcagcacttg ctcaacatac accttagctc 4800
aagtttacaa tcacattttg gaagaagaca aaagaaggag acaggtggtg gatgtcatgt 4860
ctgcaatttt ccaaggacca atttctttag acgctccacc accaccagct atagcagatc 4920
tgttacaatc agttagaaca cctgaggtaa tcaagtactg tcaagataat aaatggatca 4980
ttccagcaga gtgccaagtg gaaagagact taaatatagc cagtagcata atagctatta 5040
tagcaaatat aataagtata gctggcatta tacttgtaat ttataaattg ttttgttcat 5100
tacaaggacc atactcaggt gaacctaaac ctaaaaccaa agtacctgaa agaagagtag 5160
ttgctcaagg tccagaagaa gaatttggaa ggtcaattct caaaaacaat acttgtgtga 5220
ttactacagg taatggaaaa tttacaggtc ttggtataca tgacagaatt ctaatcatcc 5280
caacacatgc tgatccaggt agagaggtcc aagttaatgg tgtccacact aaggttctag 5340
actcatatga tctttataat agagatggag ttaaacttga aataacggtc atacaattag 5400
atagaaatga aaaatttagg gacattagaa agtatatacc tgaaacagaa gacgattatc 5460
cagaatgcaa tttggcactt tcagctaatc aagatgaacc aactataatt aaagtaggag 5520
atgtagtgtc ctatggcaat attttgctta gtggaaatca aacagccaga atgcttaaat 5580
ataattaccc cacaaaatct gggtattgtg gaggggtact atataaaatt ggtcaaattc 5640
taggtattca tgtgggtgga aatggaaggg atggtttttc agccatgtta cttagatcat 5700
actttacaga tactcagggc caaattaaag tcaataagca tgctactgaa tgtggtcttc 5760
caactataca cactcctagc aaaaccaaac ttcagcctag tgtattttat gatgtcttcc 5820
aaccagctgt gctcacagat aatgacccta gattggaagt taattttaaa gaagctttat 5880
tttctaaata taaaggtaat gtggaatgta atttgaatga acatatggaa attgctattg 5940
cccattactc agcacaatta atgacactag atattgattc caggccaata gcattggaag 6000
atagcgtgtt tggaatagaa ggacttgagg ctttagatct aaacaccagt gcagggtttc 6060
cttatgtcac aatgggtatt aaaaagagag atttaataaa taacaaaaca aaagatatat 6120
ccaggcttaa agaggctcta gataaatatg gagttgactt acccatgatc actttcttaa 6180
aagacgagct taggaaaaag gagaaaattt caacaggtaa aactagagtt atagaagcaa 6240
gtagtataaa tgacacaata ttatttagaa ctacttttgg caatttgttc tctaagtttc 6300
atttaaaccc aggcgttgtt actggctctg cagtagggtg tgaccctgag actttctggt 6360
ctaaaatccc agttatgctt gatggagatt gtataatggc ttttgactat acaaattatg 6420
atggtagtat acaccctgtc tggtttcaag ctctgaaaaa agttcttgaa aatttatctt 6480
tccaatctaa tttaattgat agattgtgtt attccaagca cttgtttaaa tcaacatatt 6540
atgaagtggc aggtggagtt ccttctgggt gttctggaac cagtatattc aatactatga 6600
ttaataacat tataataaga acactagttc tagatgcata caaaaatatt gatctggaca 6660
agcttaaaat aattgcatat ggtgatgatg tgattttctc ttataaatat actctagata 6720
tggaagctat tgctaatgaa ggaaagaaat atggacttac aataacacca gcagataagt 6780
ccaatgaatt caagaaactt gattatagta atgtgacttt tcttaaacgt ggttttaagc 6840
aagatgaaag acatacattc cttattcatc ctacattccc agtggaagag atacatgaat 6900
caattagatg gaccaagaaa ccttcacaga tgcaagaaca tgtgctatca ttatgtcacc 6960
tgatgtggca caatggacgt aaggtgtatg aagatttctc tagtaagata cgcagtgtca 7020
gcgctggacg tgcactgtat atcccacctt atgatctgtt gaaacatgaa tggtatgaaa 7080
aattttagat atagaaataa tgaatgaatg attctttaat tctataaaaa aaaaaaaaaa 7140
aaaaaaaaaa aaaaaa 7156
<210> 61
<211> 7169
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 61
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag atattgcctc acatccctta gccacaaccc tcattggtga gatagcaagt 1920
tactttacac actggacagg gagcctgcga ttcagtttca tgttttgcgg gactgcaaac 1980
actaccttaa aagttttgct agcatataca cccccaggga ttggtaagcc tagaagtaga 2040
aaggaagcaa tgttagggac acacgtggtg tgggatgtag gtttacaatc tacagtgtca 2100
ttggttgtac catggatcag tgccagtcag tatagattca ctacaccaga cacatactcc 2160
tcagcaggct acattacatg ctggtatcaa actaattttg ttgttccacc aaacacacct 2220
aacactgctg agatgttgtg ttttgtatct ggatgcaagg acttttgcct tcggatggca 2280
agagacacag acctgcacaa gcaaacagga ccaataacac aaaatccagt ggaaagatat 2340
gtagatgaag tcttaaatga agtgttagta gtgcccaata ttaatgagag ccaccctacc 2400
acatcaaatg cggccccagt tttggatgct gctgaaacag gacataccaa taagatacag 2460
ccagaagaca ctatagaaac cagatatgtg caatcttcac agacattgga tgaaatgagt 2520
gtggaaagct tcctaggcag atcggggtgc atccatgaat cagtgttgga tattgtggac 2580
aattacaatg atcaaagttt cactaaatgg aagataaacc tgcaagaaat ggcacaaatt 2640
agaagaaaat ttgaaatgtt tacttatgca agatttgact ctgaaattac tatggtacca 2700
agtgtagcag ccaaagatgg tcacattggt catatagtca tgcaatatat gtatgtacca 2760
ccaggagcac ctataccaac aactagaaat gactatgctt ggcaatctgg aacaaatgca 2820
tctgtatttt ggcagcatgg gcaacctttc cctcgctttt cacttccctt tttgagtatt 2880
gcatcagcat attacatgtt ttatgatggt tatgatggag acacatataa atccagatat 2940
ggaactgtag tcaccaatga catgggaact ttgtgttcgc gtattgtgac cagtgagcaa 3000
ttacacaaag tcaaagtggt aacaaggata tatcacaaag ccaaacacac caaagcttgg 3060
tgcccaagac cacccagagc tgttcaatac tcacatacac ataccaccaa ctacaaattg 3120
agttcagaag tacacaatga tgtggctata agacctagaa caaatctaac aactgttggg 3180
cctagtgaca tgtatgtgca tgttggtaat ctaatataca gaaatctaca tttatttaac 3240
tctgacatac atgattccat tttagtgtct tattcatcag atttaatcat ataccgaaca 3300
agcacacaag gtgatgatta tattccaaca tgtaattgca ctgaagctac atattactgc 3360
aaacacaaaa acaggtacta cccaattaat gtcacacctc atgactggta tgagatacaa 3420
gagagtgaat attatccaaa acatatccag tacaatttac taataggtga aggaccatgt 3480
gaaccaggtg attgtggtgg gaaattatta tgcaaacatg gagtgatagg tattattaca 3540
gcaggtggtg agggccatgt tgcattcata gatcttagac actttcactg tgctgaagaa 3600
caaggaatca ctgattacat acacatgctc ggcgaagctt ttggcagtgg atttgtagat 3660
agtgttaaag accagattaa ttcaataaat cccatcaata acattagcag taagatggtt 3720
aaatggatgt taagaattat atcagctatg gttataatta ttagaaactc ttcagatccg 3780
caaacaataa ttgccacttt aacactgatt ggatgcaatg gttctccttg gagatttctc 3840
aaagaaaagt tctgtaaatg gactcaatta acttatatac acaaagaatc agattcatgg 3900
ctcaaaaaat tcactgagat gtgtaatgca gctagggggc tagaatggat tggaaacaaa 3960
atatccaaat ttatcgattg gatgaaatca atgctacccc aggcacaatt aaaagttaag 4020
tatttgagtg aacttaagaa actcaacttt ctggagaaac aggttgaaaa tctcagagca 4080
gctgatacta acactcaaga aaaaatcaag tgtgagatag atacattgca tgacttatcc 4140
tgtaagtttt tacctctgta tgccagtgaa gcaaagagaa ttaaagtgtt gtatcacaag 4200
tgcactaaca taattaaaca gaagaagaga agtgaacctg tagcagttat gatacacggg 4260
cctcctggga ccggaaaatc aatcactaca agcttcctgg ctagaatgat tactaatgag 4320
agtgacatat actcacttcc accagaccct aaatattttg atggttatga taaccagagt 4380
gtagtaataa tggatgacat catgcaaaac cctggtggtg aggacatgac attattctgt 4440
cagatggtat ctagtgtgac ttttataccc ccaatggctg atctaccaga taagggaaaa 4500
ccctttgatt ctagatttgt attgtgtagt actaatcact cactcttggc acccccaact 4560
atatcgtcgc tcccagcaat gaatagaaga ttctatttag atttagatat tcttgtgcat 4620
gataactaca aagataatca gggtaagtta gatgtttcta gagcatttcg actatgtgat 4680
gttgattcaa agattggaaa tgcaaaatgt tgtccatttg tatgtggcaa ggcagtgaca 4740
ttcaaggacc gcaacacatg tagaacttat tcactttccc aaatatacaa ccaaattctt 4800
gaggaagaca agagaaggag acaggtggtt gatgtcatgt ctgcaatttt ccaagggcct 4860
atatccatgg gtaaaccccc accaccagct ataacagacc ttttacactc agtaaggaca 4920
ccagaagtaa ttaagtactg ccaagacaat aaatggatag ttcctgcgga ctgccaaatt 4980
gaaagggatc tgaatatagc taatagcata atcacaatca tagctaatat catcagtata 5040
gcagggatta tatatataat ttataagctc ttttgctctc tacagggccc ttactcgggg 5100
gagcccaaac ctaagacaaa agttcccgag agaagagtgg tagctcaagg tccagaagaa 5160
gaatttggaa tgtctattat taaaaataat acctgtgttg tgaccacaac aaatggaaaa 5220
tttacaggat taggcattta tgacagaatc ttaatattac caacacatgc tgacccgggc 5280
agtgaaattc aagtaaatgg aatacacacc aaagtgcttg attcttatga cttgtttaat 5340
aaggaaggtg tcaagttgga aattactgtg ctaaagttag atagaaatga gaagttcagg 5400
gatatacgta agtacatacc tgaatcagaa gatgactatc ctgaatgcaa cctagcacta 5460
gtggccaatc aaacagaacc aactataatc aaagtagggg atgttgtgtc ttatggtaat 5520
atattactta gtggcacaca gacagccaga atgcttaaat ataactatcc tacaaaatct 5580
gggtattgtg gtggtgtgtt atacaagatt ggccagatct taggtataca tgtgggtggc 5640
aatggtagag atgggttttc atctatgcta ttgagatcat acttcactga acaacaaggc 5700
caaattcaaa tctctaaaca tgttaaagat gttggcttac cctcaataca tacgccaact 5760
aaaactaaat tgcagccaag tgtcttctat gacatttttc caggcagtaa ggaaccagca 5820
gtcctcacag aaaaagatcc tagattgaaa gtggactttg actcagctct tttttcaaaa 5880
tacaaaggta acacagagtg cagtttgaat gaacatatac aagttgcagt agcacactac 5940
tcagctcagc tagcaacact agatatagat ccacaaccaa ttgcaatgga agatagtgtt 6000
tttggaatgg atggcttgga agctttggat ctgaatacta gtgcaggtta tccctatgta 6060
acactaggaa ttaaaaagaa agatcttatt aataacaaga ctaaagatat ttccaaactt 6120
aagctagcat tagacaaata tggtgttgat ttgcccatga ttactttctt aaaagatgaa 6180
cttagaaaga aggataagat agcagcaggc aaaaccagag ttatagaagc tagtagtata 6240
aatgatacca ttttgtttag aacagtttat ggaaacctat tttctaaatt tcacttgaac 6300
ccaggagtgg taacaggctg tgcagttgga tgtgatccag aaaccttttg gtctaaaatt 6360
cccttgatgt tagatggaga ttgcattatg gcttttgatt atacaaatta tgatggtagc 6420
attcatccaa tttggtttaa agctctcgga atggtacttg ataatttatc ctttaaccct 6480
actctaatca atagactttg taaatcaaaa catattttca agtccacata ttatgaagtt 6540
gaaggtggtg tgccctctgg ttgttctgga actagtatat ttaactcaat gattaataat 6600
ataatcatta gaaccttagt tttggatgca tataaacata ttgatttaga taaacttaaa 6660
ataattgcct atggtgatga tgtgatcttt tcttacaagt ataaactaga catggaagcc 6720
atagccaagg aagggcagaa atatggactt actataacac ctgcagataa atctagtgaa 6780
ttcaaagaac ttgattatgg aaatgtaact tttcttaaaa gaggatttag acaagatgat 6840
aaatacaaat ttttgataca tcctactttt ccagttgaag agatttatga gtccattaga 6900
tggacaaaga aaccatctca aatgcaggag catgtcttat ccttgtgtca cttaatgtgg 6960
cacaatggtc ctgagattta taaggacttt gaaacaaaga tacgcagtgt cagcgctgga 7020
cgtgcactgt atatccctcc ttatgaactc ctaagacatg aatggtatga aaaattctag 7080
atatagaatt aataaatgaa tagtttgtta gttttataaa aaaaaaaaaa aaaaaaaaaa 7140
aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 7169
<210> 62
<211> 6959
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 62
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag gtttacaatc tacagtgtca ttggttgtac catggatcag tgccagtcag 1920
tatagattca ctacaccaga cacatactcc tcagcaggct acattacatg ctggtatcaa 1980
actaattttg ttgttccacc aaacacacct aacactgctg agatgttgtg ttttgtatct 2040
ggatgcaagg acttttgcct tcggatggca agagacacag acctgcacaa gcaaacagga 2100
ccaataacac aaaatccagt ggaaagatat gtagatgaag tcttaaatga agtgttagta 2160
gtgcccaata ttaatgagag ccaccctacc acatcaaatg cggccccagt tttggatgct 2220
gctgaaacag gacataccaa taagatacag ccagaagaca ctatagaaac cagatatgtg 2280
caatcttcac agacattgga tgaaatgagt gtggaaagct tcctaggcag atcggggtgc 2340
atccatgaat cagtgttgga tattgtggac aattacaatg atcaaagttt cactaaatgg 2400
aagataaacc tgcaagaaat ggcacaaatt agaagaaaat ttgaaatgtt tacttatgca 2460
agatttgact ctgaaattac tatggtacca agtgtagcag ccaaagatgg tcacattggt 2520
catatagtca tgcaatatat gtatgtacca ccaggagcac ctataccaac aactagaaat 2580
gactatgctt ggcaatctgg aacaaatgca tctgtatttt ggcagcatgg gcaacctttc 2640
cctcgctttt cacttccctt tttgagtatt gcatcagcat attacatgtt ttatgatggt 2700
tatgatggag acacatataa atccagatat ggaactgtag tcaccaatga catgggaact 2760
ttgtgttcgc gtattgtgac cagtgagcaa ttacacaaag tcaaagtggt aacaaggata 2820
tatcacaaag ccaaacacac caaagcttgg tgcccaagac cacccagagc tgttcaatac 2880
tcacatacac ataccaccaa ctacaaattg agttcagaag tacacaatga tgtggctata 2940
agacctagaa caaatctaac aactgttggg cctagtgaca tgtatgtgca tgttggtaat 3000
ctaatataca gaaatctaca tttatttaac tctgacatac atgattccat tttagtgtct 3060
tattcatcag atttaatcat ataccgaaca agcacacaag gtgatgatta tattccaaca 3120
tgtaattgca ctgaagctac atattactgc aaacacaaaa acaggtacta cccaattaat 3180
gtcacacctc atgactggta tgagatacaa gagagtgaat attatccaaa acatatccag 3240
tacaatttac taataggtga aggaccatgt gaaccaggtg attgtggtgg gaaattatta 3300
tgcaaacatg gagtgatagg tattattaca gcaggtggtg agggccatgt tgcattcata 3360
gatcttagac actttcactg tgctgaagaa caaggaatca ctgattacat acacatgctc 3420
ggcgaagctt ttggcagtgg atttgtagat agtgttaaag accagattaa ttcaataaat 3480
cccatcaata acattagcag taagatggtt aaatggatgt taagaattat atcagctatg 3540
gttataatta ttagaaactc ttcagatccg caaacaataa ttgccacttt aacactgatt 3600
ggatgcaatg gttctccttg gagatttctc aaagaaaagt tctgtaaatg gactcaatta 3660
acttatatac acaaagaatc agattcatgg ctcaaaaaat tcactgagat gtgtaatgca 3720
gctagggggc tagaatggat tggaaacaaa atatccaaat ttatcgattg gatgaaatca 3780
atgctacccc aggcacaatt aaaagttaag tatttgagtg aacttaagaa actcaacttt 3840
ctggagaaac aggttgaaaa tctcagagca gctgatacta acactcaaga aaaaatcaag 3900
tgtgagatag atacattgca tgacttatcc tgtaagtttt tacctctgta tgccagtgaa 3960
gcaaagagaa ttaaagtgtt gtatcacaag tgcactaaca taattaaaca gaagaagaga 4020
agtgaacctg tagcagttat gatacacggg cctcctggga ccggaaaatc aatcactaca 4080
agcttcctgg ctagaatgat tactaatgag agtgacatat actcacttcc accagaccct 4140
aaatattttg atggttatga taaccagagt gtagtaataa tggatgacat catgcaaaac 4200
cctggtggtg aggacatgac attattctgt cagatggtat ctagtgtgac ttttataccc 4260
ccaatggctg atctaccaga taagggaaaa ccctttgatt ctagatttgt attgtgtagt 4320
actaatcact cactcttggc acccccaact atatcgtcgc tcccagcaat gaatagaaga 4380
ttctatttag atttagatat tcttgtgcat gataactaca aagataatca gggtaagtta 4440
gatgtttcta gagcatttcg actatgtgat gttgattcaa agattggaaa tgcaaaatgt 4500
tgtccatttg tatgtggcaa ggcagtgaca ttcaaggacc gcaacacatg tagaacttat 4560
tcactttccc aaatatacaa ccaaattctt gaggaagaca agagaaggag acaggtggtt 4620
gatgtcatgt ctgcaatttt ccaagggcct atatccatgg gtaaaccccc accaccagct 4680
ataacagacc ttttacactc agtaaggaca ccagaagtaa ttaagtactg ccaagacaat 4740
aaatggatag ttcctgcgga ctgccaaatt gaaagggatc tgaatatagc taatagcata 4800
atcacaatca tagctaatat catcagtata gcagggatta tatatataat ttataagctc 4860
ttttgctctc tacagggccc ttactcgggg gagcccaaac ctaagacaaa agttcccgag 4920
agaagagtgg tagctcaagg tccagaagaa gaatttggaa tgtctattat taaaaataat 4980
acctgtgttg tgaccacaac aaatggaaaa tttacaggat taggcattta tgacagaatc 5040
ttaatattac caacacatgc tgacccgggc agtgaaattc aagtaaatgg aatacacacc 5100
aaagtgcttg attcttatga cttgtttaat aaggaaggtg tcaagttgga aattactgtg 5160
ctaaagttag atagaaatga gaagttcagg gatatacgta agtacatacc tgaatcagaa 5220
gatgactatc ctgaatgcaa cctagcacta gtggccaatc aaacagaacc aactataatc 5280
aaagtagggg atgttgtgtc ttatggtaat atattactta gtggcacaca gacagccaga 5340
atgcttaaat ataactatcc tacaaaatct gggtattgtg gtggtgtgtt atacaagatt 5400
ggccagatct taggtataca tgtgggtggc aatggtagag atgggttttc atctatgcta 5460
ttgagatcat acttcactga acaacaaggc caaattcaaa tctctaaaca tgttaaagat 5520
gttggcttac cctcaataca tacgccaact aaaactaaat tgcagccaag tgtcttctat 5580
gacatttttc caggcagtaa ggaaccagca gtcctcacag aaaaagatcc tagattgaaa 5640
gtggactttg actcagctct tttttcaaaa tacaaaggta acacagagtg cagtttgaat 5700
gaacatatac aagttgcagt agcacactac tcagctcagc tagcaacact agatatagat 5760
ccacaaccaa ttgcaatgga agatagtgtt tttggaatgg atggcttgga agctttggat 5820
ctgaatacta gtgcaggtta tccctatgta acactaggaa ttaaaaagaa agatcttatt 5880
aataacaaga ctaaagatat ttccaaactt aagctagcat tagacaaata tggtgttgat 5940
ttgcccatga ttactttctt aaaagatgaa cttagaaaga aggataagat agcagcaggc 6000
aaaaccagag ttatagaagc tagtagtata aatgatacca ttttgtttag aacagtttat 6060
ggaaacctat tttctaaatt tcacttgaac ccaggagtgg taacaggctg tgcagttgga 6120
tgtgatccag aaaccttttg gtctaaaatt cccttgatgt tagatggaga ttgcattatg 6180
gcttttgatt atacaaatta tgatggtagc attcatccaa tttggtttaa agctctcgga 6240
atggtacttg ataatttatc ctttaaccct actctaatca atagactttg taaatcaaaa 6300
catattttca agtccacata ttatgaagtt gaaggtggtg tgccctctgg ttgttctgga 6360
actagtatat ttaactcaat gattaataat ataatcatta gaaccttagt tttggatgca 6420
tataaacata ttgatttaga taaacttaaa ataattgcct atggtgatga tgtgatcttt 6480
tcttacaagt ataaactaga catggaagcc atagccaagg aagggcagaa atatggactt 6540
actataacac ctgcagataa atctagtgaa ttcaaagaac ttgattatgg aaatgtaact 6600
tttcttaaaa gaggatttag acaagatgat aaatacaaat ttttgataca tcctactttt 6660
ccagttgaag agatttatga gtccattaga tggacaaaga aaccatctca aatgcaggag 6720
catgtcttat ccttgtgtca cttaatgtgg cacaatggtc ctgagattta taaggacttt 6780
gaaacaaaga tacgcagtgt cagcgctgga cgtgcactgt atatccctcc ttatgaactc 6840
ctaagacatg aatggtatga aaaattctag atatagaatt aataaatgaa tagtttgtta 6900
gttttataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 6959
<210> 63
<211> 6958
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 63
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaatagg tttacaatct acagtgtcat tggttgtacc atggatcagt gccagtcagt 1920
atagattcac tacaccagac acatactcct cagcaggcta cattacatgc tggtatcaaa 1980
ctaattttgt tgttccacca aacacaccta acactgctga gatgttgtgt tttgtatctg 2040
gatgcaagga cttttgcctt cggatggcaa gagacacaga cctgcacaag caaacaggac 2100
caataacaca aaatccagtg gaaagatatg tagatgaagt cttaaatgaa gtgttagtag 2160
tgcccaatat taatgagagc caccctacca catcaaatgc ggccccagtt ttggatgctg 2220
ctgaaacagg acataccaat aagatacagc cagaagacac tatagaaacc agatatgtgc 2280
aatcttcaca gacattggat gaaatgagtg tggaaagctt cctaggcaga tcggggtgca 2340
tccatgaatc agtgttggat attgtggaca attacaatga tcaaagtttc actaaatgga 2400
agataaacct gcaagaaatg gcacaaatta gaagaaaatt tgaaatgttt acttatgcaa 2460
gatttgactc tgaaattact atggtaccaa gtgtagcagc caaagatggt cacattggtc 2520
atatagtcat gcaatatatg tatgtaccac caggagcacc tataccaaca actagaaatg 2580
actatgcttg gcaatctgga acaaatgcat ctgtattttg gcagcatggg caacctttcc 2640
ctcgcttttc acttcccttt ttgagtattg catcagcata ttacatgttt tatgatggtt 2700
atgatggaga cacatataaa tccagatatg gaactgtagt caccaatgac atgggaactt 2760
tgtgttcgcg tattgtgacc agtgagcaat tacacaaagt caaagtggta acaaggatat 2820
atcacaaagc caaacacacc aaagcttggt gcccaagacc acccagagct gttcaatact 2880
cacatacaca taccaccaac tacaaattga gttcagaagt acacaatgat gtggctataa 2940
gacctagaac aaatctaaca actgttgggc ctagtgacat gtatgtgcat gttggtaatc 3000
taatatacag aaatctacat ttatttaact ctgacataca tgattccatt ttagtgtctt 3060
attcatcaga tttaatcata taccgaacaa gcacacaagg tgatgattat attccaacat 3120
gtaattgcac tgaagctaca tattactgca aacacaaaaa caggtactac ccaattaatg 3180
tcacacctca tgactggtat gagatacaag agagtgaata ttatccaaaa catatccagt 3240
acaatttact aataggtgaa ggaccatgtg aaccaggtga ttgtggtggg aaattattat 3300
gcaaacatgg agtgataggt attattacag caggtggtga gggccatgtt gcattcatag 3360
atcttagaca ctttcactgt gctgaagaac aaggaatcac tgattacata cacatgctcg 3420
gcgaagcttt tggcagtgga tttgtagata gtgttaaaga ccagattaat tcaataaatc 3480
ccatcaataa cattagcagt aagatggtta aatggatgtt aagaattata tcagctatgg 3540
ttataattat tagaaactct tcagatccgc aaacaataat tgccacttta acactgattg 3600
gatgcaatgg ttctccttgg agatttctca aagaaaagtt ctgtaaatgg actcaattaa 3660
cttatataca caaagaatca gattcatggc tcaaaaaatt cactgagatg tgtaatgcag 3720
ctagggggct agaatggatt ggaaacaaaa tatccaaatt tatcgattgg atgaaatcaa 3780
tgctacccca ggcacaatta aaagttaagt atttgagtga acttaagaaa ctcaactttc 3840
tggagaaaca ggttgaaaat ctcagagcag ctgatactaa cactcaagaa aaaatcaagt 3900
gtgagataga tacattgcat gacttatcct gtaagttttt acctctgtat gccagtgaag 3960
caaagagaat taaagtgttg tatcacaagt gcactaacat aattaaacag aagaagagaa 4020
gtgaacctgt agcagttatg atacacgggc ctcctgggac cggaaaatca atcactacaa 4080
gcttcctggc tagaatgatt actaatgaga gtgacatata ctcacttcca ccagacccta 4140
aatattttga tggttatgat aaccagagtg tagtaataat ggatgacatc atgcaaaacc 4200
ctggtggtga ggacatgaca ttattctgtc agatggtatc tagtgtgact tttatacccc 4260
caatggctga tctaccagat aagggaaaac cctttgattc tagatttgta ttgtgtagta 4320
ctaatcactc actcttggca cccccaacta tatcgtcgct cccagcaatg aatagaagat 4380
tctatttaga tttagatatt cttgtgcatg ataactacaa agataatcag ggtaagttag 4440
atgtttctag agcatttcga ctatgtgatg ttgattcaaa gattggaaat gcaaaatgtt 4500
gtccatttgt atgtggcaag gcagtgacat tcaaggaccg caacacatgt agaacttatt 4560
cactttccca aatatacaac caaattcttg aggaagacaa gagaaggaga caggtggttg 4620
atgtcatgtc tgcaattttc caagggccta tatccatggg taaaccccca ccaccagcta 4680
taacagacct tttacactca gtaaggacac cagaagtaat taagtactgc caagacaata 4740
aatggatagt tcctgcggac tgccaaattg aaagggatct gaatatagct aatagcataa 4800
tcacaatcat agctaatatc atcagtatag cagggattat atatataatt tataagctct 4860
tttgctctct acagggccct tactcggggg agcccaaacc taagacaaaa gttcccgaga 4920
gaagagtggt agctcaaggt ccagaagaag aatttggaat gtctattatt aaaaataata 4980
cctgtgttgt gaccacaaca aatggaaaat ttacaggatt aggcatttat gacagaatct 5040
taatattacc aacacatgct gacccgggca gtgaaattca agtaaatgga atacacacca 5100
aagtgcttga ttcttatgac ttgtttaata aggaaggtgt caagttggaa attactgtgc 5160
taaagttaga tagaaatgag aagttcaggg atatacgtaa gtacatacct gaatcagaag 5220
atgactatcc tgaatgcaac ctagcactag tggccaatca aacagaacca actataatca 5280
aagtagggga tgttgtgtct tatggtaata tattacttag tggcacacag acagccagaa 5340
tgcttaaata taactatcct acaaaatctg ggtattgtgg tggtgtgtta tacaagattg 5400
gccagatctt aggtatacat gtgggtggca atggtagaga tgggttttca tctatgctat 5460
tgagatcata cttcactgaa caacaaggcc aaattcaaat ctctaaacat gttaaagatg 5520
ttggcttacc ctcaatacat acgccaacta aaactaaatt gcagccaagt gtcttctatg 5580
acatttttcc aggcagtaag gaaccagcag tcctcacaga aaaagatcct agattgaaag 5640
tggactttga ctcagctctt ttttcaaaat acaaaggtaa cacagagtgc agtttgaatg 5700
aacatataca agttgcagta gcacactact cagctcagct agcaacacta gatatagatc 5760
cacaaccaat tgcaatggaa gatagtgttt ttggaatgga tggcttggaa gctttggatc 5820
tgaatactag tgcaggttat ccctatgtaa cactaggaat taaaaagaaa gatcttatta 5880
ataacaagac taaagatatt tccaaactta agctagcatt agacaaatat ggtgttgatt 5940
tgcccatgat tactttctta aaagatgaac ttagaaagaa ggataagata gcagcaggca 6000
aaaccagagt tatagaagct agtagtataa atgataccat tttgtttaga acagtttatg 6060
gaaacctatt ttctaaattt cacttgaacc caggagtggt aacaggctgt gcagttggat 6120
gtgatccaga aaccttttgg tctaaaattc ccttgatgtt agatggagat tgcattatgg 6180
cttttgatta tacaaattat gatggtagca ttcatccaat ttggtttaaa gctctcggaa 6240
tggtacttga taatttatcc tttaacccta ctctaatcaa tagactttgt aaatcaaaac 6300
atattttcaa gtccacatat tatgaagttg aaggtggtgt gccctctggt tgttctggaa 6360
ctagtatatt taactcaatg attaataata taatcattag aaccttagtt ttggatgcat 6420
ataaacatat tgatttagat aaacttaaaa taattgccta tggtgatgat gtgatctttt 6480
cttacaagta taaactagac atggaagcca tagccaagga agggcagaaa tatggactta 6540
ctataacacc tgcagataaa tctagtgaat tcaaagaact tgattatgga aatgtaactt 6600
ttcttaaaag aggatttaga caagatgata aatacaaatt tttgatacat cctacttttc 6660
cagttgaaga gatttatgag tccattagat ggacaaagaa accatctcaa atgcaggagc 6720
atgtcttatc cttgtgtcac ttaatgtggc acaatggtcc tgagatttat aaggactttg 6780
aaacaaagat acgcagtgtc agcgctggac gtgcactgta tatccctcct tatgaactcc 6840
taagacatga atggtatgaa aaattctaga tatagaatta ataaatgaat agtttgttag 6900
ttttataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 6958
<210> 64
<211> 7124
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 64
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag atattgcctc acatccctta gccacaaccc tcattggtga gatagcaagt 1920
tactttacac actggacagg gagcctgcga ttcagtttca tgttttgcgg gactgcaaac 1980
actaccttaa aagttttgct agcatataca cccccaggga ttggtaagcc tagaagtaga 2040
aaggaagcaa tgttagggac acacgtggtg tgggatgtag gtttacaatc tacagtgtca 2100
ttggttgtac catggatcag tgccagtcag tatagattca ctacaccaga cacatactcc 2160
tcagcaggct acattacatg ctggtatcaa actaattttg ttgttccacc aaacacacct 2220
aacactgctg agatgttgtg ttttgtatct ggatgcaagg acttttgcct tcggatggca 2280
agagacacag acctgcacaa gcaaacagga ccaataacac aaaatccagt ggaaagatat 2340
gtagatgaag tcttaaatga agtgttagta gtgcccaata ttaatgagag ccaccctacc 2400
acatcaaatg cggccccagt tttggatgct gctgaaacag gacataccaa taagatacag 2460
ccagaagaca ctatagaaac cagatatgtg caatcttcac agacattgga tgaaatgagt 2520
gtggaaagct tcctaggcag atcggggtgc atccatgaat cagtgttgga tattgtggac 2580
aattacaatg atcaaagttt cactaaatgg aagataaacc tgcaagaaat ggcacaaatt 2640
agaagaaaat ttgaaatgtt tacttatgca agatttgact ctgaaattac tatggtacca 2700
agtgtagcag ccaaagatgg tcacattggt catatagtca tgcaatatat gtatgtacca 2760
ccaggagcac ctataccaac aactagaaat gactatgctt ggcaatctgg aacaaatgca 2820
tctgtatttt ggcagcatgg gcaacctttc cctcgctttt cacttccctt tttgagtatt 2880
gcatcagcat attacatgtt ttatgatggt tatgatggag acacatataa atccagatat 2940
ggaactgtag tcaccaatga catgggaact ttgtgttcgc gtattgtgac cagtgagcaa 3000
ttacacaaag tcaaagtggt aacaaggata tatcacaaag ccaaacacac caaagcttgg 3060
tgcccaagac cacccagagc tgttcaatac tcacatacac ataccaccaa ctacaaattg 3120
agttcagaag tacacaatga tgtggctata agacctagaa caaatctaat atacagaaat 3180
ctacatttat ttaactctga catacatgat tccattttag tgtcttattc atcagattta 3240
atcatatacc gaacaagcac acaaggtgat gattatattc caacatgtaa ttgcactgaa 3300
gctacatatt actgcaaaca caaaaacagg tactacccaa ttaatgtcac acctcatgac 3360
tggtatgaga tacaagagag tgaatattat ccaaaacata tccagtacaa tttactaata 3420
ggtgaaggac catgtgaacc aggtgattgt ggtgggaaat tattatgcaa acatggagtg 3480
ataggtatta ttacagcagg tggtgagggc catgttgcat tcatagatct tagacacttt 3540
cactgtgctg aagaacaagg aatcactgat tacatacaca tgctcggcga agcttttggc 3600
agtggatttg tagatagtgt taaagaccag attaattcaa taaatcccat caataacatt 3660
agcagtaaga tggttaaatg gatgttaaga attatatcag ctatggttat aattattaga 3720
aactcttcag atccgcaaac aataattgcc actttaacac tgattggatg caatggttct 3780
ccttggagat ttctcaaaga aaagttctgt aaatggactc aattaactta tatacacaaa 3840
gaatcagatt catggctcaa aaaattcact gagatgtgta atgcagctag ggggctagaa 3900
tggattggaa acaaaatatc caaatttatc gattggatga aatcaatgct accccaggca 3960
caattaaaag ttaagtattt gagtgaactt aagaaactca actttctgga gaaacaggtt 4020
gaaaatctca gagcagctga tactaacact caagaaaaaa tcaagtgtga gatagataca 4080
ttgcatgact tatcctgtaa gtttttacct ctgtatgcca gtgaagcaaa gagaattaaa 4140
gtgttgtatc acaagtgcac taacataatt aaacagaaga agagaagtga acctgtagca 4200
gttatgatac acgggcctcc tgggaccgga aaatcaatca ctacaagctt cctggctaga 4260
atgattacta atgagagtga catatactca cttccaccag accctaaata ttttgatggt 4320
tatgataacc agagtgtagt aataatggat gacatcatgc aaaaccctgg tggtgaggac 4380
atgacattat tctgtcagat ggtatctagt gtgactttta tacccccaat ggctgatcta 4440
ccagataagg gaaaaccctt tgattctaga tttgtattgt gtagtactaa tcactcactc 4500
ttggcacccc caactatatc gtcgctccca gcaatgaata gaagattcta tttagattta 4560
gatattcttg tgcatgataa ctacaaagat aatcagggta agttagatgt ttctagagca 4620
tttcgactat gtgatgttga ttcaaagatt ggaaatgcaa aatgttgtcc atttgtatgt 4680
ggcaaggcag tgacattcaa ggaccgcaac acatgtagaa cttattcact ttcccaaata 4740
tacaaccaaa ttcttgagga agacaagaga aggagacagg tggttgatgt catgtctgca 4800
attttccaag ggcctatatc catgggtaaa cccccaccac cagctataac agacctttta 4860
cactcagtaa ggacaccaga agtaattaag tactgccaag acaataaatg gatagttcct 4920
gcggactgcc aaattgaaag ggatctgaat atagctaata gcataatcac aatcatagct 4980
aatatcatca gtatagcagg gattatatat ataatttata agctcttttg ctctctacag 5040
ggcccttact cgggggagcc caaacctaag acaaaagttc ccgagagaag agtggtagct 5100
caaggtccag aagaagaatt tggaatgtct attattaaaa ataatacctg tgttgtgacc 5160
acaacaaatg gaaaatttac aggattaggc atttatgaca gaatcttaat attaccaaca 5220
catgctgacc cgggcagtga aattcaagta aatggaatac acaccaaagt gcttgattct 5280
tatgacttgt ttaataagga aggtgtcaag ttggaaatta ctgtgctaaa gttagataga 5340
aatgagaagt tcagggatat acgtaagtac atacctgaat cagaagatga ctatcctgaa 5400
tgcaacctag cactagtggc caatcaaaca gaaccaacta taatcaaagt aggggatgtt 5460
gtgtcttatg gtaatatatt acttagtggc acacagacag ccagaatgct taaatataac 5520
tatcctacaa aatctgggta ttgtggtggt gtgttataca agattggcca gatcttaggt 5580
atacatgtgg gtggcaatgg tagagatggg ttttcatcta tgctattgag atcatacttc 5640
actgaacaac aaggccaaat tcaaatctct aaacatgtta aagatgttgg cttaccctca 5700
atacatacgc caactaaaac taaattgcag ccaagtgtct tctatgacat ttttccaggc 5760
agtaaggaac cagcagtcct cacagaaaaa gatcctagat tgaaagtgga ctttgactca 5820
gctctttttt caaaatacaa aggtaacaca gagtgcagtt tgaatgaaca tatacaagtt 5880
gcagtagcac actactcagc tcagctagca acactagata tagatccaca accaattgca 5940
atggaagata gtgtttttgg aatggatggc ttggaagctt tggatctgaa tactagtgca 6000
ggttatccct atgtaacact aggaattaaa aagaaagatc ttattaataa caagactaaa 6060
gatatttcca aacttaagct agcattagac aaatatggtg ttgatttgcc catgattact 6120
ttcttaaaag atgaacttag aaagaaggat aagatagcag caggcaaaac cagagttata 6180
gaagctagta gtataaatga taccattttg tttagaacag tttatggaaa cctattttct 6240
aaatttcact tgaacccagg agtggtaaca ggctgtgcag ttggatgtga tccagaaacc 6300
ttttggtcta aaattccctt gatgttagat ggagattgca ttatggcttt tgattataca 6360
aattatgatg gtagcattca tccaatttgg tttaaagctc tcggaatggt acttgataat 6420
ttatccttta accctactct aatcaataga ctttgtaaat caaaacatat tttcaagtcc 6480
acatattatg aagttgaagg tggtgtgccc tctggttgtt ctggaactag tatatttaac 6540
tcaatgatta ataatataat cattagaacc ttagttttgg atgcatataa acatattgat 6600
ttagataaac ttaaaataat tgcctatggt gatgatgtga tcttttctta caagtataaa 6660
ctagacatgg aagccatagc caaggaaggg cagaaatatg gacttactat aacacctgca 6720
gataaatcta gtgaattcaa agaacttgat tatggaaatg taacttttct taaaagagga 6780
tttagacaag atgataaata caaatttttg atacatccta cttttccagt tgaagagatt 6840
tatgagtcca ttagatggac aaagaaacca tctcaaatgc aggagcatgt cttatccttg 6900
tgtcacttaa tgtggcacaa tggtcctgag atttataagg actttgaaac aaagatacgc 6960
agtgtcagcg ctggacgtgc actgtatatc cctccttatg aactcctaag acatgaatgg 7020
tatgaaaaat tctagatata gaattaataa atgaatagtt tgttagtttt ataaaaaaaa 7080
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 7124
<210> 65
<211> 5978
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 65
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag atattgcctc acatccctta gccacaaccc tcattggtga gatagcaagt 1920
tactttacac actggacagg gagcctgcga ttcagtttca tgttttgcgg gactgcaaac 1980
actaccttaa aagttttgct agcatataca cccccaggga ttggtaagcc tagaagtaga 2040
aaggaagcaa tgttagggac acacgtggtg tgggatgtag gtttacaatc tacagtgtca 2100
ttggttgtac catggatcag tgccagtcag tatagattca ctacaccaga cacatactcc 2160
tcagcaggct acattacatg ctggtatcaa actaattttg ttgttccacc aaacacacct 2220
aacactgctg agatgttgtg ttttgtatct ggatgcaagg acttttgcct tcggatggca 2280
agagacacag acctgcacaa gcaaacagga ccaataacac aaaatccagt ggaaagatat 2340
gtagatgaag tcttaaatga agtgttagta gtgcccaata ttaatgagag ccaccctacc 2400
acatcaaatg cggccccagt tttggatgct gctgaaacag gacataccaa taagatacag 2460
ccagaagaca ctatagaaac cagatatgtg caatcttcac agacattgga tgaaatgagt 2520
gtggaaagct tcctaggcag atcggggtgc atccatgaat cagtgttgga tattgtggac 2580
aattacaatg atcaaagttt cactaaatgg aagataaacc tgcaagaaat ggcacaaatt 2640
agaagaaaat ttgaaatgtt tacttatgca agatttgact ctgaaattac tatggtacca 2700
agtgtagcag ccaaagatgg tcacattggt catatagtca tgcaatatat gtatgtacca 2760
ccaggagcac ctataccaac aactagaaat gactatgctt ggcaatctgg aacaaatgca 2820
tctgtatttt ggcagcatgg gcaacctttc cctcgctttt cacttccctt tttgagtatt 2880
gcatcagcat attacatgtt ttatgatggt tatgataagt gtgagataga tacattgcat 2940
gacttatcct gtaagttttt acctctgtat gccagtgaag caaagagaat taaagtgttg 3000
tatcacaagt gcactaacat aattaaacag aagaagagaa gtgaacctgt agcagttatg 3060
atacacgggc ctcctgggac cggaaaatca atcactacaa gcttcctggc tagaatgatt 3120
actaatgaga gtgacatata ctcacttcca ccagacccta aatattttga tggttatgat 3180
aaccagagtg tagtaataat ggatgacatc atgcaaaacc ctggtggtga ggacatgaca 3240
ttattctgtc agatggtatc tagtgtgact tttatacccc caatggctga tctaccagat 3300
aagggaaaac cctttgattc tagatttgta ttgtgtagta ctaatcactc actcttggca 3360
cccccaacta tatcgtcgct cccagcaatg aatagaagat tctatttaga tttagatatt 3420
cttgtgcatg ataactacaa agataatcag ggtaagttag atgtttctag agcatttcga 3480
ctatgtgatg ttgattcaaa gattggaaat gcaaaatgtt gtccatttgt atgtggcaag 3540
gcagtgacat tcaaggaccg caacacatgt agaacttatt cactttccca aatatacaac 3600
caaattcttg aggaagacaa gagaaggaga caggtggttg atgtcatgtc tgcaattttc 3660
caagggccta tatccatggg taaaccccca ccaccagcta taacagacct tttacactca 3720
gtaaggacac cagaagtaat taagtactgc caagacaata aatggatagt tcctgcggac 3780
tgccaaattg aaagggatct gaatatagct aatagcataa tcacaatcat agctaatatc 3840
atcagtatag cagggattat atatataatt tataagctct tttgctctct acagggccct 3900
tactcggggg agcccaaacc taagacaaaa gttcccgaga gaagagtggt agctcaaggt 3960
ccagaagaag aatttggaat gtctattatt aaaaataata cctgtgttgt gaccacaaca 4020
aatggaaaat ttacaggatt aggcatttat gacagaatct taatattacc aacacatgct 4080
gacccgggca gtgaaattca agtaaatgga atacacacca aagtgcttga ttcttatgac 4140
ttgtttaata aggaaggtgt caagttggaa attactgtgc taaagttaga tagaaatgag 4200
aagttcaggg atatacgtaa gtacatacct gaatcagaag atgactatcc tgaatgcaac 4260
ctagcactag tggccaatca aacagaacca actataatca aagtagggga tgttgtgtct 4320
tatggtaata tattacttag tggcacacag acagccagaa tgcttaaata taactatcct 4380
acaaaatctg ggtattgtgg tggtgtgtta tacaagattg gccagatctt aggtatacat 4440
gtgggtggca atggtagaga tgggttttca tctatgctat tgagatcata cttcactgaa 4500
caacaaggcc aaattcaaat ctctaaacat gttaaagatg ttggcttacc ctcaatacat 4560
acgccaacta aaactaaatt gcagccaagt gtcttctatg acatttttcc aggcagtaag 4620
gaaccagcag tcctcacaga aaaagatcct agattgaaag tggactttga ctcagctctt 4680
ttttcaaaat acaaaggtaa cacagagtgc agtttgaatg aacatataca agttgcagta 4740
gcacactact cagctcagct agcaacacta gatatagatc cacaaccaat tgcaatggaa 4800
gatagtgttt ttggaatgga tggcttggaa gctttggatc tgaatactag tgcaggttat 4860
ccctatgtaa cactaggaat taaaaagaaa gatcttatta ataacaagac taaagatatt 4920
tccaaactta agctagcatt agacaaatat ggtgttgatt tgcccatgat tactttctta 4980
aaagatgaac ttagaaagaa ggataagata gcagcaggca aaaccagagt tatagaagct 5040
agtagtataa atgataccat tttgtttaga acagtttatg gaaacctatt ttctaaattt 5100
cacttgaacc caggagtggt aacaggctgt gcagttggat gtgatccaga aaccttttgg 5160
tctaaaattc ccttgatgtt agatggagat tgcattatgg cttttgatta tacaaattat 5220
gatggtagca ttcatccaat ttggtttaaa gctctcggaa tggtacttga taatttatcc 5280
tttaacccta ctctaatcaa tagactttgt aaatcaaaac atattttcaa gtccacatat 5340
tatgaagttg aaggtggtgt gccctctggt tgttctggaa ctagtatatt taactcaatg 5400
attaataata taatcattag aaccttagtt ttggatgcat ataaacatat tgatttagat 5460
aaacttaaaa taattgccta tggtgatgat gtgatctttt cttacaagta taaactagac 5520
atggaagcca tagccaagga agggcagaaa tatggactta ctataacacc tgcagataaa 5580
tctagtgaat tcaaagaact tgattatgga aatgtaactt ttcttaaaag aggatttaga 5640
caagatgata aatacaaatt tttgatacat cctacttttc cagttgaaga gatttatgag 5700
tccattagat ggacaaagaa accatctcaa atgcaggagc atgtcttatc cttgtgtcac 5760
ttaatgtggc acaatggtcc tgagatttat aaggactttg aaacaaagat acgcagtgtc 5820
agcgctggac gtgcactgta tatccctcct tatgaactcc taagacatga atggtatgaa 5880
aaattctaga tatagaatta ataaatgaat agtttgttag ttttataaaa aaaaaaaaaa 5940
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 5978
<210> 66
<211> 7012
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 66
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag atattgcctc acatccctta gccacaaccc tcattggtga gatagcaagt 1920
tactttacac actggacagg gagcctgcga ttcagtttca tgttttgcgg gactgcaaac 1980
actaccttaa aagttttgct agcatataca cccccaggga ttggtaagcc tagaagtaga 2040
aaggaagcaa tgttagggac acacgtggtg tgggatgtag gtttacaatc tacagtgtca 2100
ttggttgtac catggatcag tgccagtcag tatagattca ctacaccaga cacatactcc 2160
tcagcaggct acattacatg ctggtatcaa actaattttg ttgttccacc aaacacacct 2220
aacactgctg agatgttgtg ttttgtatct ggatgcaagg acttttgcct tcggatggca 2280
agagacacag acctgcacaa gcaaacagga ccaataacac aaaatccagt ggaaagatat 2340
gtagatgaag tcttaaatga agtgttagta gtgcccaata ttaatgagag ccaccctacc 2400
acatcaaatg cggccccagt tttggatgct gctgaaacag gacataccaa taagatacag 2460
ccagaagaca ctatagaaac cagatatgtg caatcttcac agacattgga tgaaatgagt 2520
gtggaaagct tcctaggcag atcggggtgc atccatgaat cagtgttgga tattgtggac 2580
aattacaatg atcaaagttt cactaaatgg aagataaacc tgcaagaaat ggcacaaatt 2640
agaagaaaat ttgaaatgtt tacttatgca agatttgact ctgaaattac tatggtacca 2700
agtgtagcag ccaaagatgg tcacattggt catatagtca tgcaatatat gtatgtacca 2760
ccaggagcac ctataccaac aactagaaat gactatgctt ggcaatctgg aacaaatgca 2820
tctgtatttt ggcagcatgg gcaacctttc cctcgctttt cacttccctt tttgagtatt 2880
gcatcagcat attacatgtt ttatgatggt tatgatggag acacatataa atccagatat 2940
ggaactgtag tcaccaatga catgggaact ttgtgttcgc gtattgtgac cagtgagcaa 3000
ttacacaaag tcaaagtggt aacaaggata tatcacaaag ccaaacacac caaagcttgg 3060
tgcccaagac cacccagagc tgttcaatac tcacatacac ataccaccaa ctacaaattg 3120
agttcagaag tacacaatga tgtggctata agacctagaa caaatctaac aactgttggg 3180
cctagtgaca tgtatgtgca tgttggtaat ctaatataca gaaatctaca tttatttaac 3240
tctgacatac atgattccat tttagtgtct tattcatcag atttaatcat ataccgaaca 3300
agcacacaag gtgatgatta tattccaaca tgtaattgca ctgaagctac atattactgc 3360
aaacacaaaa acaggtacta cccaattaat gtcacacctc atgactggta tgagatacaa 3420
gagagtgaat attatccaaa acatatccag tacaatttac taataggtga aggaccatgt 3480
gaaccaggtg attgtggtgg gaaattatta tgcaaacatg gagtgatagg tattattaca 3540
gcaggtggtg agggccatgt tgcattcata gatcttagac actttcactg tgctgaagaa 3600
caaggaatca ctgattacat acacatgctc ggcgaagctt ttggcagtgg atttgtagat 3660
agtgttaaag accagattaa ttcaataaat cccatcaata acattagcag taagatggtt 3720
aaatggatgt taagaattat atcagctatg gttataatta ttagaaactc ttcagatccg 3780
caaacaataa ttgccacttt aacactgatt ggatgcaatg gttctccttg gagatttctc 3840
aaagaaaagt tctgtaaatg gactcaatta acttatatac acaaagaatc agattcatgg 3900
ctcaaaaaat tcactgagat gtgtaatgca gctagggggc tagaatggat tggaaacaaa 3960
atatccaaat ttatcgattg gatgaaatca atgctacccc aggcacaatt aaaagttaag 4020
tatttgagtg aacttaagaa actcaacttt ctggagaaac aggttgaaaa tctcagagca 4080
gctgatacta acactcaaga aaaaatcaag tgtgagatag atacattgca tgacttatcc 4140
tggctagaat gattactaat gagagtgaca tatactcact tccaccagac cctaaatatt 4200
ttgatggtta tgataaccag agtgtagtaa taatggatga catcatgcaa aaccctggtg 4260
gtgaggacat gacattattc tgtcagatgg tatctagtgt gacttttata cccccaatgg 4320
ctgatctacc agataaggga aaaccctttg attctagatt tgtattgtgt agtactaatc 4380
actcactctt ggcaccccca actatatcgt cgctcccagc aatgaataga agattctatt 4440
tagatttaga tattcttgtg catgataact acaaagataa tcagggtaag ttagatgttt 4500
ctagagcatt tcgactatgt gatgttgatt caaagattgg aaatgcaaaa tgttgtccat 4560
ttgtatgtgg caaggcagtg acattcaagg accgcaacac atgtagaact tattcacttt 4620
cccaaatata caaccaaatt cttgaggaag acaagagaag gagacaggtg gttgatgtca 4680
tgtctgcaat tttccaaggg cctatatcca tgggtaaacc cccaccacca gctataacag 4740
accttttaca ctcagtaagg acaccagaag taattaagta ctgccaagac aataaatgga 4800
tagttcctgc ggactgccaa attgaaaggg atctgaatat agctaatagc ataatcacaa 4860
tcatagctaa tatcatcagt atagcaggga ttatatatat aatttataag ctcttttgct 4920
ctctacaggg cccttactcg ggggagccca aacctaagac aaaagttccc gagagaagag 4980
tggtagctca aggtccagaa gaagaatttg gaatgtctat tattaaaaat aatacctgtg 5040
ttgtgaccac aacaaatgga aaatttacag gattaggcat ttatgacaga atcttaatat 5100
taccaacaca tgctgacccg ggcagtgaaa ttcaagtaaa tggaatacac accaaagtgc 5160
ttgattctta tgacttgttt aataaggaag gtgtcaagtt ggaaattact gtgctaaagt 5220
tagatagaaa tgagaagttc agggatatac gtaagtacat acctgaatca gaagatgact 5280
atcctgaatg caacctagca ctagtggcca atcaaacaga accaactata atcaaagtag 5340
gggatgttgt gtcttatggt aatatattac ttagtggcac acagacagcc agaatgctta 5400
aatataacta tcctacaaaa tctgggtatt gtggtggtgt gttatacaag attggccaga 5460
tcttaggtat acatgtgggt ggcaatggta gagatgggtt ttcatctatg ctattgagat 5520
catacttcac tgaacaacaa ggccaaattc aaatctctaa acatgttaaa gatgttggct 5580
taccctcaat acatacgcca actaaaacta aattgcagcc aagtgtcttc tatgacattt 5640
ttccaggcag taaggaacca gcagtcctca cagaaaaaga tcctagattg aaagtggact 5700
ttgactcagc tcttttttca aaatacaaag gtaacacaga gtgcagtttg aatgaacata 5760
tacaagttgc agtagcacac tactcagctc agctagcaac actagatata gatccacaac 5820
caattgcaat ggaagatagt gtttttggaa tggatggctt ggaagctttg gatctgaata 5880
ctagtgcagg ttatccctat gtaacactag gaattaaaaa gaaagatctt attaataaca 5940
agactaaaga tatttccaaa cttaagctag cattagacaa atatggtgtt gatttgccca 6000
tgattacttt cttaaaagat gaacttagaa agaaggataa gatagcagca ggcaaaacca 6060
gagttataga agctagtagt ataaatgata ccattttgtt tagaacagtt tatggaaacc 6120
tattttctaa atttcacttg aacccaggag tggtaacagg ctgtgcagtt ggatgtgatc 6180
cagaaacctt ttggtctaaa attcccttga tgttagatgg agattgcatt atggcttttg 6240
attatacaaa ttatgatggt agcattcatc caatttggtt taaagctctc ggaatggtac 6300
ttgataattt atcctttaac cctactctaa tcaatagact ttgtaaatca aaacatattt 6360
tcaagtccac atattatgaa gttgaaggtg gtgtgccctc tggttgttct ggaactagta 6420
tatttaactc aatgattaat aatataatca ttagaacctt agttttggat gcatataaac 6480
atattgattt agataaactt aaaataattg cctatggtga tgatgtgatc ttttcttaca 6540
agtataaact agacatggaa gccatagcca aggaagggca gaaatatgga cttactataa 6600
cacctgcaga taaatctagt gaattcaaag aacttgatta tggaaatgta acttttctta 6660
aaagaggatt tagacaagat gataaataca aatttttgat acatcctact tttccagttg 6720
aagagattta tgagtccatt agatggacaa agaaaccatc tcaaatgcag gagcatgtct 6780
tatccttgtg tcacttaatg tggcacaatg gtcctgagat ttataaggac tttgaaacaa 6840
agatacgcag tgtcagcgct ggacgtgcac tgtatatccc tccttatgaa ctcctaagac 6900
atgaatggta tgaaaaattc tagatataga attaataaat gaatagtttg ttagttttat 6960
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 7012
<210> 67
<211> 7223
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 67
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagaaag agctatgaat caagccagca tgattattaa 5100
tactattctg atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc 5160
tcaaactcaa ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt 5220
acgcccagtt gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa 5280
cataatgact ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt 5340
ctgtgtgata cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat 5400
tagagttaag gataagtaca aattagtaga tccagagaac attaatctag agcttacagt 5460
gttgacttta gatagaaatg aaaaattcag agatatcagg ggatttatat cagaagatct 5520
agaaggtgtg gatgccactt tggtagtaca ttcaaataac tttaccaaca ctatcttaga 5580
agttggccct gtaacaatgg caggacttat taatttgagt agcaccccca ctaacagaat 5640
gattcgttat gattatgcaa caaaaactgg gcagtgtgga ggtgtgctgt gtgctactgg 5700
taagatcttt ggtattcatg ttggcggtaa tggaagacaa ggattttcag ctcaacttaa 5760
aaaacaatat tttgtagaga aacaaggcca agtaatagct agacataagg ttagggagtt 5820
taacataaat ccagtcaaca cgccaaccaa gtcaaaatta catcccagtg tattctatga 5880
tgttttccca ggtgacaagg aacctgctgt attgagtgac aatgatccca gactggaagt 5940
taaattgact gaatcattat tctctaagta caaggggaat gtaaatacgg aacccactga 6000
aaatatgctt gtggctgtag accattatgc agggcaacta ttatcactag atatccccac 6060
ttctgaactt acactaaaag aagcattata tggagtagat ggactagaac ctatagatat 6120
tacaaccagt gcaggatttc cctatgtgag tcttgggatc aaaaagagag acattctgaa 6180
taaagagacc caggacacag aaaagatgaa gttttatcta gacaagtatg gcattgactt 6240
gcctctagtt acatatatta aggatgaatt aagaagtgtt gacaaagtcc gattagggaa 6300
aagtagatta attgaagcct ccagtttgaa tgattctgtt aacatgagaa tgaaactagg 6360
caacctttac aaagcattcc atcaaaatcc cggtgttctg actggatcag cagtgggttg 6420
tgatcctgat gtgttttggt ctgtcatccc ttgcttaatg gatgggcacc tgatggcatt 6480
tgattactct aattttgatg cctctttgtc accagtttgg tttgtctgtc tagagaaggt 6540
tttgaccaag ttaggctttg caggctcttc attaattcaa tcaatttgta atacccatca 6600
tatctttagg gatgaaatat atgtggttga aggtggcatg ccctcagggt gttcaggaac 6660
cagcatattc aattccatga tcaacaacat aatcattagg actttgatat tagatgcata 6720
taaaggaata gatttagaca aacttaaaat cttagcttac ggtgatgatt tgattgtttc 6780
ttatccttat gaactggatc cgcaagtgtt ggcaactctt ggtaaaaatt atggactaac 6840
catcacaccc ccagacaaat ctgaaacttt tacaaaaatg acatgggaaa acttgacatt 6900
tttaaagaga tacttcaagc ctgatcaaca atttcccttt ttggttcacc cagttatgcc 6960
catgaaagat atacatgagt caatcagatg gacaaaggat cctaaaaaca cacaggatca 7020
cgtccgatca ttatgcatgt tagcatggca ctcaggagaa aaagagtaca atgaattcat 7080
tcagaagatc agaactactg acattggaaa atgtctaatt ctcccagaat acagcgtact 7140
taggaggcgc tggttggacc tcttttaggt taacaatata gacacttaat ttgagtagaa 7200
gtaggagttt ataaaaaaaa aaa 7223
<210> 68
<211> 6014
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 68
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaaagctta ggctgatgaa 1080
agatactcaa actatctcac agactgttgc actcactgaa ggcttaggtg atgaattaga 1140
agaagtcatc gttgagaaaa cgaaacagac ggtggcctca atctcatctg gtccaaaaca 1200
cacacaaaaa gtccccatac taactgcaaa cgaaacaggg gccacaatgc ctgttcttcc 1260
atcagacagc atagaaacca gaactaccta catgcacttt aatggttcag aaactgatgt 1320
agaatgcttt ttgggtcgtg cagcttgtgt gcatgtaact gaaatacaaa acaaagatgc 1380
tactggaata gataatcaca gagaagcaaa attgttcaat gattggaaaa tcaacctgtc 1440
cagccttgtc caacttagaa agaaactaga actcttcact tatgttaggt ttgattctga 1500
gtataccata ctggccactg catctcaacc tgattcagca aactattcaa gcaatttggt 1560
ggtccaagcc atgtatgttc cacctggtgc cccgaatcca aaagagtggg acgattacac 1620
atggcaaagt gcttcaaacc ccagtgtatt cttcaaggtg ggggatacat ccaggtttag 1680
tgtgccttat gtaggattgg catcagcata taattgtttt tatgatggtt actcacatga 1740
tgatgcagaa actcagtatg gcataactgt tctaaaccat atgggtagta tggcattcag 1800
aatagtaaat gaacatgatg aacataaaac tcttgtcaag atcagagttt atcacagggc 1860
aaagcacgtt gaagcatgga ttccaagagc acccagagca ctaccctaca catcaatagg 1920
gcgcacaaat tatcctaaga atacagaacc agtaattaag aagaggaaag gtgacattaa 1980
atcctatggt ttaggaccta ggtacggtgg gatttataca tcaaatgtta aaataatgaa 2040
ttaccacttg atgacaccag aagaccacca taatctgata gcaccctatc caaatagaga 2100
tttagcaata gtctcaacag gaggacatgg tgcagaaaca ataccacact gtaactgtac 2160
atcaggtgtt tactattcca catattacag aaagtattac cccataattt gtgaaaagcc 2220
caccaacatc tggattgaag gaaaccctta ttacccaagt agatttcaag caggagtgat 2280
gaaaggggtt gggccagcag aaccaggaga ctgcggtggg attttgagat gcatacatgg 2340
tcccattgga ttgttaacag ctggaggtag tggatatgtt tgttttgctg acatacgaca 2400
gttggagtgt atcgcagagg aacaggggct gagtgattac atcacaggtt tgggtagagc 2460
ttttggtgtc gggttcactg accaaatctc aacaaaagtc acagaactac aagaagtggc 2520
gaaagatttc ctcaccacaa aagttttgtc caaagtggtc aaaatggttt cagctttagt 2580
gatcatttgc agaaatcatg atgacttggt cactgttacg gccactctag cactacttgg 2640
atgtgatgga tctccctgga gatttctgaa gatgtacatt tccaaacact ttcaggtgcc 2700
ttacattgaa agacaagcaa atgatggatg gttcagaaag tttaatgatg catgtaatgc 2760
tgcaaaggga ttggaatgga ttgctaataa gatttccaaa ctgattgaat ggataaaaaa 2820
caaagtactt ccccaagcca aagaaaaact agaattttgt agtaaactca aacaacttga 2880
tatactagag agacaaataa ccaccatgca tatctcgaat ccaacacagg aaaaacgaga 2940
gcagttgttc aacaacgtat tgtggttgga acaaatgtcg caaaagtttg ccccacatta 3000
tgccgttgaa tcaaaaagaa tcagggaact caagaacaaa atggtaaatt atatgcaatt 3060
taaaagtaaa caaagaactg aaccagtgtg tgtattaatc catggtacac ccggttctgg 3120
taaatcatta acaacatcca ttgtgggacg tgcaattgca gaacacttca attcagcagt 3180
atattcactt ccaccagatc ccaagcactt tgatggttat cagcaacagg aagttgtgat 3240
tatggatgat ctgaaccaaa atccagacgg acaggatata agcatgtttt gtcaaatggt 3300
ttcttcagtg gatttcttgc ctccaatggc tagtttagat aacaagggca tgttattcac 3360
cagtaatttt gttctagcct ccacaaattc taacacacta agccccccaa caatcttgaa 3420
tcctgaagct ttagtcagga gatttggttt tgacctggat atatgtttgc atactaccta 3480
cacaaagaat ggaaaactca atgcaggcat gtcaaccaag acatgcaaag attgccatca 3540
accatctaat ttcaagaaat gttgccccct ggtctgtgga aaagctatta gcttggtaga 3600
cagaactacc aacgttaggt atagtgtgga tcaactggtc acagctatta taagtgattt 3660
caagagcaaa atgcaaatta cagattccct agaaacactg tttcaaggac cagtgtataa 3720
agatttagag attgatgttt gcaacacacc acctccagaa tgtatcaacg atttactgaa 3780
atctgtagat tcagaagaga ttagggaata ttgtaagaag aagaaatgga ttatacctga 3840
aattcctacc aacatagaaa gagctatgaa tcaagccagc atgattatta atactattct 3900
gatgtttgtc agtacattag gtattgttta tgtcatttat aaattgtttg ctcaaactca 3960
aggaccatat tctggtaacc cgcctcacaa taaactaaaa gccccaactt tacgcccagt 4020
tgttgtgcaa ggaccaaaca cagaatttgc actatccctg ttaaggaaaa acataatgac 4080
tataacaacc tcaaagggag agttcacagg gttaggcata catgatcgtg tctgtgtgat 4140
acccacacac gcacagcctg gtgatgatgt actagtgaat ggtcagaaaa ttagagttaa 4200
ggataagtac aaattagtag atccagagaa cattaatcta gagcttacag tgttgacttt 4260
agatagaaat gaaaaattca gagatatcag gggatttata tcagaagatc tagaaggtgt 4320
ggatgccact ttggtagtac attcaaataa ctttaccaac actatcttag aagttggccc 4380
tgtaacaatg gcaggactta ttaatttgag tagcaccccc actaacagaa tgattcgtta 4440
tgattatgca acaaaaactg ggcagtgtgg aggtgtgctg tgtgctactg gtaagatctt 4500
tggtattcat gttggcggta atggaagaca aggattttca gctcaactta aaaaacaata 4560
ttttgtagag aaacaaggcc aagtaatagc tagacataag gttagggagt ttaacataaa 4620
tccagtcaac acgccaacca agtcaaaatt acatcccagt gtattctatg atgttttccc 4680
aggtgacaag gaacctgctg tattgagtga caatgatccc agactggaag ttaaattgac 4740
tgaatcatta ttctctaagt acaaggggaa tgtaaatacg gaacccactg aaaatatgct 4800
tgtggctgta gaccattatg cagggcaact attatcacta gatatcccca cttctgaact 4860
tacactaaaa gaagcattat atggagtaga tggactagaa cctatagata ttacaaccag 4920
tgcaggattt ccctatgtga gtcttgggat caaaaagaga gacattctga ataaagagac 4980
ccaggacaca gaaaagatga agttttatct agacaagtat ggcattgact tgcctctagt 5040
tacatatatt aaggatgaat taagaagtgt tgacaaagtc cgattaggga aaagtagatt 5100
aattgaagcc tccagtttga atgattctgt taacatgaga atgaaactag gcaaccttta 5160
caaagcattc catcaaaatc ccggtgttct gactggatca gcagtgggtt gtgatcctga 5220
tgtgttttgg tctgtcatcc cttgcttaat ggatgggcac ctgatggcat ttgattactc 5280
taattttgat gcctctttgt caccagtttg gtttgtctgt ctagagaagg ttttgaccaa 5340
gttaggcttt gcaggctctt cattaattca atcaatttgt aatacccatc atatctttag 5400
ggatgaaata tatgtggttg aaggtggcat gccctcaggg tgttcaggaa ccagcatatt 5460
caattccatg atcaacaaca taatcattag gactttgata ttagatgcat ataaaggaat 5520
agatttagac aaacttaaaa tcttagctta cggtgatgat ttgattgttt cttatcctta 5580
tgaactggat ccgcaagtgt tggcaactct tggtaaaaat tatggactaa ccatcacacc 5640
cccagacaaa tctgaaactt ttacaaaaat gacatgggaa aacttgacat ttttaaagag 5700
atacttcaag cctgatcaac aatttccctt tttggttcac ccagttatgc ccatgaaaga 5760
tatacatgag tcaatcagat ggacaaagga tcctaaaaac acacaggatc acgtccgatc 5820
attatgcatg ttagcatggc actcaggaga aaaagagtac aatgaattca ttcagaagat 5880
cagaactact gacattggaa aatgtctaat tctcccagaa tacagcgtac ttaggaggcg 5940
ctggttggac ctcttttagg ttaacaatat agacacttaa tttgagtaga agtaggagtt 6000
tataaaaaaa aaaa 6014
<210> 69
<211> 6013
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 69
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaagcttag gctgatgaaa 1080
gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga tgaattagaa 1140
gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg tccaaaacac 1200
acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc tgttcttcca 1260
tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga aactgatgta 1320
gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa caaagatgct 1380
actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat caacctgtcc 1440
agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt tgattctgag 1500
tataccatac tggccactgc atctcaacct gattcagcaa actattcaag caatttggtg 1560
gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga cgattacaca 1620
tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc caggtttagt 1680
gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta ctcacatgat 1740
gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat ggcattcaga 1800
atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta tcacagggca 1860
aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac atcaataggg 1920
cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg tgacattaaa 1980
tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa aataatgaat 2040
taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc aaatagagat 2100
ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg taactgtaca 2160
tcaggtgttt actattccac atattacaga aagtattacc ccataatttg tgaaaagccc 2220
accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc aggagtgatg 2280
aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg catacatggt 2340
cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga catacgacag 2400
ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt gggtagagct 2460
tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca agaagtggcg 2520
aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc agctttagtg 2580
atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc actacttgga 2640
tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt tcaggtgcct 2700
tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc atgtaatgct 2760
gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg gataaaaaac 2820
aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa acaacttgat 2880
atactagaga gacaaataac caccatgcat atctcgaatc caacacagga aaaacgagag 2940
cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc cccacattat 3000
gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta tatgcaattt 3060
aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc cggttctggt 3120
aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa ttcagcagta 3180
tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga agttgtgatt 3240
atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg tcaaatggtt 3300
tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat gttattcacc 3360
agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac aatcttgaat 3420
cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca tactacctac 3480
acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga ttgccatcaa 3540
ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag cttggtagac 3600
agaactacca acgttaggta tagtgtggat caactggtca cagctattat aagtgatttc 3660
aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc agtgtataaa 3720
gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga tttactgaaa 3780
tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat tatacctgaa 3840
attcctacca acatagaaag agctatgaat caagccagca tgattattaa tactattctg 3900
atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc tcaaactcaa 3960
ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt acgcccagtt 4020
gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa cataatgact 4080
ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt ctgtgtgata 4140
cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat tagagttaag 4200
gataagtaca aattagtaga tccagagaac attaatctag agcttacagt gttgacttta 4260
gatagaaatg aaaaattcag agatatcagg ggatttatat cagaagatct agaaggtgtg 4320
gatgccactt tggtagtaca ttcaaataac tttaccaaca ctatcttaga agttggccct 4380
gtaacaatgg caggacttat taatttgagt agcaccccca ctaacagaat gattcgttat 4440
gattatgcaa caaaaactgg gcagtgtgga ggtgtgctgt gtgctactgg taagatcttt 4500
ggtattcatg ttggcggtaa tggaagacaa ggattttcag ctcaacttaa aaaacaatat 4560
tttgtagaga aacaaggcca agtaatagct agacataagg ttagggagtt taacataaat 4620
ccagtcaaca cgccaaccaa gtcaaaatta catcccagtg tattctatga tgttttccca 4680
ggtgacaagg aacctgctgt attgagtgac aatgatccca gactggaagt taaattgact 4740
gaatcattat tctctaagta caaggggaat gtaaatacgg aacccactga aaatatgctt 4800
gtggctgtag accattatgc agggcaacta ttatcactag atatccccac ttctgaactt 4860
acactaaaag aagcattata tggagtagat ggactagaac ctatagatat tacaaccagt 4920
gcaggatttc cctatgtgag tcttgggatc aaaaagagag acattctgaa taaagagacc 4980
caggacacag aaaagatgaa gttttatcta gacaagtatg gcattgactt gcctctagtt 5040
acatatatta aggatgaatt aagaagtgtt gacaaagtcc gattagggaa aagtagatta 5100
attgaagcct ccagtttgaa tgattctgtt aacatgagaa tgaaactagg caacctttac 5160
aaagcattcc atcaaaatcc cggtgttctg actggatcag cagtgggttg tgatcctgat 5220
gtgttttggt ctgtcatccc ttgcttaatg gatgggcacc tgatggcatt tgattactct 5280
aattttgatg cctctttgtc accagtttgg tttgtctgtc tagagaaggt tttgaccaag 5340
ttaggctttg caggctcttc attaattcaa tcaatttgta atacccatca tatctttagg 5400
gatgaaatat atgtggttga aggtggcatg ccctcagggt gttcaggaac cagcatattc 5460
aattccatga tcaacaacat aatcattagg actttgatat tagatgcata taaaggaata 5520
gatttagaca aacttaaaat cttagcttac ggtgatgatt tgattgtttc ttatccttat 5580
gaactggatc cgcaagtgtt ggcaactctt ggtaaaaatt atggactaac catcacaccc 5640
ccagacaaat ctgaaacttt tacaaaaatg acatgggaaa acttgacatt tttaaagaga 5700
tacttcaagc ctgatcaaca atttcccttt ttggttcacc cagttatgcc catgaaagat 5760
atacatgagt caatcagatg gacaaaggat cctaaaaaca cacaggatca cgtccgatca 5820
ttatgcatgt tagcatggca ctcaggagaa aaagagtaca atgaattcat tcagaagatc 5880
agaactactg acattggaaa atgtctaatt ctcccagaat acagcgtact taggaggcgc 5940
tggttggacc tcttttaggt taacaatata gacacttaat ttgagtagaa gtaggagttt 6000
ataaaaaaaa aaa 6013
<210> 70
<211> 6767
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 70
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 71
<211> 6766
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 71
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atatacagaa 2700
ccagtaatta agaagaggaa aggtgacatt aaatcctatg gtttaggacc taggtacggt 2760
gggatttata catcaaatgt taaaataatg aattaccact tgatgacacc agaagaccac 2820
cataatctga tagcacccta tccaaataga gatttagcaa tagtctcaac aggaggacat 2880
ggtgcagaaa caataccaca ctgtaactgt acatcaggtg tttactattc cacatattac 2940
agaaagtatt accccataat ttgtgaaaag cccaccaaca tctggattga aggaaaccct 3000
tattacccaa gtagatttca agcaggagtg atgaaagggg ttgggccagc agaaccagga 3060
gactgcggtg ggattttgag atgcatacat ggtcccattg gattgttaac agctggaggt 3120
agtggatatg tttgttttgc tgacatacga cagttggagt gtatcgcaga ggaacagggg 3180
ctgagtgatt acatcacagg tttgggtaga gcttttggtg tcgggttcac tgaccaaatc 3240
tcaacaaaag tcacagaact acaagaagtg gcgaaagatt tcctcaccac aaaagttttg 3300
tccaaagtgg tcaaaatggt ttcagcttta gtgatcattt gcagaaatca tgatgacttg 3360
gtcactgtta cggccactct agcactactt ggatgtgatg gatctccctg gagatttctg 3420
aagatgtaca tttccaaaca ctttcaggtg ccttacattg aaagacaagc aaatgatgga 3480
tggttcagaa agtttaatga tgcatgtaat gctgcaaagg gattggaatg gattgctaat 3540
aagatttcca aactgattga atggataaaa aacaaagtac ttccccaagc caaagaaaaa 3600
ctagaatttt gtagtaaact caaacaactt gatatactag agagacaaat aaccaccatg 3660
catatctcga atccaacaca ggaaaaacga gagcagttgt tcaacaacgt attgtggttg 3720
gaacaaatgt cgcaaaagtt tgccccacat tatgccgttg aatcaaaaag aatcagggaa 3780
ctcaagaaca aaatggtaaa ttatatgcaa tttaaaagta aacaaagaac tgaaccagtg 3840
tgtgtattaa tccatggtac acccggttct ggtaaatcat taacaacatc cattgtggga 3900
cgtgcaattg cagaacactt caattcagca gtatattcac ttccaccaga tcccaagcac 3960
tttgatggtt atcagcaaca ggaagttgtg attatggatg atctgaacca aaatccagac 4020
ggacaggata taagcatgtt ttgtcaaatg gtttcttcag tggatttctt gcctccaatg 4080
gctagtttag ataacaaggg catgttattc accagtaatt ttgttctagc ctccacaaat 4140
tctaacacac taagcccccc aacaatcttg aatcctgaag ctttagtcag gagatttggt 4200
tttgacctgg atatatgttt gcatactacc tacacaaaga atggaaaact caatgcaggc 4260
atgtcaacca agacatgcaa agattgccat caaccatcta atttcaagaa atgttgcccc 4320
ctggtctgtg gaaaagctat tagcttggta gacagaacta ccaacgttag gtatagtgtg 4380
gatcaactgg tcacagctat tataagtgat ttcaagagca aaatgcaaat tacagattcc 4440
ctagaaacac tgtttcaagg accagtgtat aaagatttag agattgatgt ttgcaacaca 4500
ccacctccag aatgtatcaa cgatttactg aaatctgtag attcagaaga gattagggaa 4560
tattgtaaga agaagaaatg gattatacct gaaattccta ccaacataga aagagctatg 4620
aatcaagcca gcatgattat taatactatt ctgatgtttg tcagtacatt aggtattgtt 4680
tatgtcattt ataaattgtt tgctcaaact caaggaccat attctggtaa cccgcctcac 4740
aataaactaa aagccccaac tttacgccca gttgttgtgc aaggaccaaa cacagaattt 4800
gcactatccc tgttaaggaa aaacataatg actataacaa cctcaaaggg agagttcaca 4860
gggttaggca tacatgatcg tgtctgtgtg atacccacac acgcacagcc tggtgatgat 4920
gtactagtga atggtcagaa aattagagtt aaggataagt acaaattagt agatccagag 4980
aacattaatc tagagcttac agtgttgact ttagatagaa atgaaaaatt cagagatatc 5040
aggggattta tatcagaaga tctagaaggt gtggatgcca ctttggtagt acattcaaat 5100
aactttacca acactatctt agaagttggc cctgtaacaa tggcaggact tattaatttg 5160
agtagcaccc ccactaacag aatgattcgt tatgattatg caacaaaaac tgggcagtgt 5220
ggaggtgtgc tgtgtgctac tggtaagatc tttggtattc atgttggcgg taatggaaga 5280
caaggatttt cagctcaact taaaaaacaa tattttgtag agaaacaagg ccaagtaata 5340
gctagacata aggttaggga gtttaacata aatccagtca acacgccaac caagtcaaaa 5400
ttacatccca gtgtattcta tgatgttttc ccaggtgaca aggaacctgc tgtattgagt 5460
gacaatgatc ccagactgga agttaaattg actgaatcat tattctctaa gtacaagggg 5520
aatgtaaata cggaacccac tgaaaatatg cttgtggctg tagaccatta tgcagggcaa 5580
ctattatcac tagatatccc cacttctgaa cttacactaa aagaagcatt atatggagta 5640
gatggactag aacctataga tattacaacc agtgcaggat ttccctatgt gagtcttggg 5700
atcaaaaaga gagacattct gaataaagag acccaggaca cagaaaagat gaagttttat 5760
ctagacaagt atggcattga cttgcctcta gttacatata ttaaggatga attaagaagt 5820
gttgacaaag tccgattagg gaaaagtaga ttaattgaag cctccagttt gaatgattct 5880
gttaacatga gaatgaaact aggcaacctt tacaaagcat tccatcaaaa tcccggtgtt 5940
ctgactggat cagcagtggg ttgtgatcct gatgtgtttt ggtctgtcat cccttgctta 6000
atggatgggc acctgatggc atttgattac tctaattttg atgcctcttt gtcaccagtt 6060
tggtttgtct gtctagagaa ggttttgacc aagttaggct ttgcaggctc ttcattaatt 6120
caatcaattt gtaataccca tcatatcttt agggatgaaa tatatgtggt tgaaggtggc 6180
atgccctcag ggtgttcagg aaccagcata ttcaattcca tgatcaacaa cataatcatt 6240
aggactttga tattagatgc atataaagga atagatttag acaaacttaa aatcttagct 6300
tacggtgatg atttgattgt ttcttatcct tatgaactgg atccgcaagt gttggcaact 6360
cttggtaaaa attatggact aaccatcaca cccccagaca aatctgaaac ttttacaaaa 6420
atgacatggg aaaacttgac atttttaaag agatacttca agcctgatca acaatttccc 6480
tttttggttc acccagttat gcccatgaaa gatatacatg agtcaatcag atggacaaag 6540
gatcctaaaa acacacagga tcacgtccga tcattatgca tgttagcatg gcactcagga 6600
gaaaaagagt acaatgaatt cattcagaag atcagaacta ctgacattgg aaaatgtcta 6660
attctcccag aatacagcgt acttaggagg cgctggttgg acctctttta ggttaacaat 6720
atagacactt aatttgagta gaagtaggag tttataaaaa aaaaaa 6766
<210> 72
<211> 6767
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 72
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttactca aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 73
<211> 6767
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 73
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaaggc tcaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 74
<211> 6767
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 74
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcctcgatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 75
<211> 6767
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 75
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
agacctccca gaatacagcg tacttaggga ccgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 76
<211> 6767
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 76
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgcg gcgttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 77
<211> 5558
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 77
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaaagctta ggctgatgaa 1080
agatactcaa actatctcac agactgttgc actcactgaa ggcttaggtg atgaattaga 1140
agaagtcatc gttgagaaaa cgaaacagac ggtggcctca atctcatctg gtccaaaaca 1200
cacacaaaaa gtccccatac taactgcaaa cgaaacaggg gccacaatgc ctgttcttcc 1260
atcagacagc atagaaacca gaactaccta catgcacttt aatggttcag aaactgatgt 1320
agaatgcttt ttgggtcgtg cagcttgtgt gcatgtaact gaaatacaaa acaaagatgc 1380
tactggaata gataatcaca gagaagcaaa attgttcaat gattggaaaa tcaacctgtc 1440
cagccttgtc caacttagaa agaaactaga actcttcact tataatacag aaccagtaat 1500
taagaagagg aaaggtgaca ttaaatccta tggtttagga cctaggtacg gtgggattta 1560
tacatcaaat gttaaaataa tgaattacca cttgatgaca ccagaagacc accataatct 1620
gatagcaccc tatccaaata gagatttagc aatagtctca acaggaggac atggtgcaga 1680
aacaatacca cactgtaact gtacatcagg tgtttactat tccacatatt acagaaagta 1740
ttaccccata atttgtgaaa agcccaccaa catctggatt gaaggaaacc cttattaccc 1800
aagtagattt caagcaggag tgatgaaagg ggttgggcca gcagaaccag gagactgcgg 1860
tgggattttg agatgcatac atggtcccat tggattgtta acagctggag gtagtggata 1920
tgtttgtttt gctgacatac gacagttgga gtgtatcgca gaggaacagg ggctgagtga 1980
ttacatcaca ggtttgggta gagcttttgg tgtcgggttc actgaccaaa tctcaacaaa 2040
agtcacagaa ctacaagaag tggcgaaaga tttcctcacc acaaaagttt tgtccaaagt 2100
ggtcaaaatg gtttcagctt tagtgatcat ttgcagaaat catgatgact tggtcactgt 2160
tacggccact ctagcactac ttggatgtga tggatctccc tggagatttc tgaagatgta 2220
catttccaaa cactttcagg tgccttacat tgaaagacaa gcaaatgatg gatggttcag 2280
aaagtttaat gatgcatgta atgctgcaaa gggattggaa tggattgcta ataagatttc 2340
caaactgatt gaatggataa aaaacaaagt acttccccaa gccaaagaaa aactagaatt 2400
ttgtagtaaa ctcaaacaac ttgatatact agagagacaa ataaccacca tgcatatctc 2460
gaatccaaca caggaaaaac gagagcagtt gttcaacaac gtattgtggt tggaacaaat 2520
gtcgcaaaag tttgccccac attatgccgt tgaatcaaaa agaatcaggg aactcaagaa 2580
caaaatggta aattatatgc aatttaaaag taaacaaaga actgaaccag tgtgtgtatt 2640
aatccatggt acacccggtt ctggtaaatc attaacaaca tccattgtgg gacgtgcaat 2700
tgcagaacac ttcaattcag cagtatattc acttccacca gatcccaagc actttgatgg 2760
ttatcagcaa caggaagttg tgattatgga tgatctgaac caaaatccag acggacagga 2820
tataagcatg ttttgtcaaa tggtttcttc agtggatttc ttgcctccaa tggctagttt 2880
agataacaag ggcatgttat tcaccagtaa ttttgttcta gcctccacaa attctaacac 2940
actaagcccc ccaacaatct tgaatcctga agctttagtc aggagatttg gttttgacct 3000
ggatatatgt ttgcatacta cctacacaaa gaatggaaaa ctcaatgcag gcatgtcaac 3060
caagacatgc aaagattgcc atcaaccatc taatttcaag aaatgttgcc ccctggtctg 3120
tggaaaagct attagcttgg tagacagaac taccaacgtt aggtatagtg tggatcaact 3180
ggtcacagct attataagtg atttcaagag caaaatgcaa attacagatt ccctagaaac 3240
actgtttcaa ggaccagtgt ataaagattt agagattgat gtttgcaaca caccacctcc 3300
agaatgtatc aacgatttac tgaaatctgt agattcagaa gagattaggg aatattgtaa 3360
gaagaagaaa tggattatac ctgaaattcc taccaacata gaaagagcta tgaatcaagc 3420
cagcatgatt attaatacta ttctgatgtt tgtcagtaca ttaggtattg tttatgtcat 3480
ttataaattg tttgctcaaa ctcaaggacc atattctggt aacccgcctc acaataaact 3540
aaaagcccca actttacgcc cagttgttgt gcaaggacca aacacagaat ttgcactatc 3600
cctgttaagg aaaaacataa tgactataac aacctcaaag ggagagttca cagggttagg 3660
catacatgat cgtgtctgtg tgatacccac acacgcacag cctggtgatg atgtactagt 3720
gaatggtcag aaaattagag ttaaggataa gtacaaatta gtagatccag agaacattaa 3780
tctagagctt acagtgttga ctttagatag aaatgaaaaa ttcagagata tcaggggatt 3840
tatatcagaa gatctagaag gtgtggatgc cactttggta gtacattcaa ataactttac 3900
caacactatc ttagaagttg gccctgtaac aatggcagga cttattaatt tgagtagcac 3960
ccccactaac agaatgattc gttatgatta tgcaacaaaa actgggcagt gtggaggtgt 4020
gctgtgtgct actggtaaga tctttggtat tcatgttggc ggtaatggaa gacaaggatt 4080
ttcagctcaa cttaaaaaac aatattttgt agagaaacaa ggccaagtaa tagctagaca 4140
taaggttagg gagtttaaca taaatccagt caacacgcca accaagtcaa aattacatcc 4200
cagtgtattc tatgatgttt tcccaggtga caaggaacct gctgtattga gtgacaatga 4260
tcccagactg gaagttaaat tgactgaatc attattctct aagtacaagg ggaatgtaaa 4320
tacggaaccc actgaaaata tgcttgtggc tgtagaccat tatgcagggc aactattatc 4380
actagatatc cccacttctg aacttacact aaaagaagca ttatatggag tagatggact 4440
agaacctata gatattacaa ccagtgcagg atttccctat gtgagtcttg ggatcaaaaa 4500
gagagacatt ctgaataaag agacccagga cacagaaaag atgaagtttt atctagacaa 4560
gtatggcatt gacttgcctc tagttacata tattaaggat gaattaagaa gtgttgacaa 4620
agtccgatta gggaaaagta gattaattga agcctccagt ttgaatgatt ctgttaacat 4680
gagaatgaaa ctaggcaacc tttacaaagc attccatcaa aatcccggtg ttctgactgg 4740
atcagcagtg ggttgtgatc ctgatgtgtt ttggtctgtc atcccttgct taatggatgg 4800
gcacctgatg gcatttgatt actctaattt tgatgcctct ttgtcaccag tttggtttgt 4860
ctgtctagag aaggttttga ccaagttagg ctttgcaggc tcttcattaa ttcaatcaat 4920
ttgtaatacc catcatatct ttagggatga aatatatgtg gttgaaggtg gcatgccctc 4980
agggtgttca ggaaccagca tattcaattc catgatcaac aacataatca ttaggacttt 5040
gatattagat gcatataaag gaatagattt agacaaactt aaaatcttag cttacggtga 5100
tgatttgatt gtttcttatc cttatgaact ggatccgcaa gtgttggcaa ctcttggtaa 5160
aaattatgga ctaaccatca cacccccaga caaatctgaa acttttacaa aaatgacatg 5220
ggaaaacttg acatttttaa agagatactt caagcctgat caacaatttc cctttttggt 5280
tcacccagtt atgcccatga aagatataca tgagtcaatc agatggacaa aggatcctaa 5340
aaacacacag gatcacgtcc gatcattatg catgttagca tggcactcag gagaaaaaga 5400
gtacaatgaa ttcattcaga agatcagaac tactgacatt ggaaaatgtc taattctccc 5460
agaatacagc gtacttagga ggcgctggtt ggacctcttt taggttaaca atatagacac 5520
ttaatttgag tagaagtagg agtttataaa aaaaaaaa 5558
<210> 78
<211> 5557
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 78
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaaagctta ggctgatgaa 1080
agatactcaa actatctcac agactgttgc actcactgaa ggcttaggtg atgaattaga 1140
agaagtcatc gttgagaaaa cgaaacagac ggtggcctca atctcatctg gtccaaaaca 1200
cacacaaaaa gtccccatac taactgcaaa cgaaacaggg gccacaatgc ctgttcttcc 1260
atcagacagc atagaaacca gaactaccta catgcacttt aatggttcag aaactgatgt 1320
agaatgcttt ttgggtcgtg cagcttgtgt gcatgtaact gaaatacaaa acaaagatgc 1380
tactggaata gataatcaca gagaagcaaa attgttcaat gattggaaaa tcaacctgtc 1440
cagccttgtc caacttagaa agaaactaga actcttcact tatatacaga accagtaatt 1500
aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg tgggatttat 1560
acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca ccataatctg 1620
atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca tggtgcagaa 1680
acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta cagaaagtat 1740
taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc ttattaccca 1800
agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg agactgcggt 1860
gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg tagtggatat 1920
gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg gctgagtgat 1980
tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat ctcaacaaaa 2040
gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt gtccaaagtg 2100
gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt ggtcactgtt 2160
acggccactc tagcactact tggatgtgat ggatctccct ggagatttct gaagatgtac 2220
atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg atggttcaga 2280
aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa taagatttcc 2340
aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa actagaattt 2400
tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat gcatatctcg 2460
aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt ggaacaaatg 2520
tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga actcaagaac 2580
aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt gtgtgtatta 2640
atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg acgtgcaatt 2700
gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca ctttgatggt 2760
tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga cggacaggat 2820
ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat ggctagttta 2880
gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa ttctaacaca 2940
ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg ttttgacctg 3000
gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg catgtcaacc 3060
aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc cctggtctgt 3120
ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt ggatcaactg 3180
gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc cctagaaaca 3240
ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac accacctcca 3300
gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga atattgtaag 3360
aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat gaatcaagcc 3420
agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt ttatgtcatt 3480
tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca caataaacta 3540
aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt tgcactatcc 3600
ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac agggttaggc 3660
atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga tgtactagtg 3720
aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga gaacattaat 3780
ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat caggggattt 3840
atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa taactttacc 3900
aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt gagtagcacc 3960
cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg tggaggtgtg 4020
ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag acaaggattt 4080
tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat agctagacat 4140
aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa attacatccc 4200
agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag tgacaatgat 4260
cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg gaatgtaaat 4320
acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca actattatca 4380
ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt agatggacta 4440
gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg gatcaaaaag 4500
agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta tctagacaag 4560
tatggcattg acttgcctct agttacatat attaaggatg aattaagaag tgttgacaaa 4620
gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc tgttaacatg 4680
agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt tctgactgga 4740
tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt aatggatggg 4800
cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt ttggtttgtc 4860
tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat tcaatcaatt 4920
tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg catgccctca 4980
gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat taggactttg 5040
atattagatg catataaagg aatagattta gacaaactta aaatcttagc ttacggtgat 5100
gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac tcttggtaaa 5160
aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa aatgacatgg 5220
gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc ctttttggtt 5280
cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa ggatcctaaa 5340
aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg agaaaaagag 5400
tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct aattctccca 5460
gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa tatagacact 5520
taatttgagt agaagtagga gtttataaaa aaaaaaa 5557
<210> 79
<211> 7148
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 79
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaaca 3180
cttgatgaca ccagaagacc accataatct gatagcaccc tatccaaata gagatttagc 3240
aatagtctca acaggaggac atggtgcaga aacaatacca cactgtaact gtacatcagg 3300
tgtttactat tccacatatt acagaaagta ttaccccata atttgtgaaa agcccaccaa 3360
catctggatt gaaggaaacc cttattaccc aagtagattt caagcaggag tgatgaaagg 3420
ggttgggcca gcagaaccag gagactgcgg tgggattttg agatgcatac atggtcccat 3480
tggattgtta acagctggag gtagtggata tgtttgtttt gctgacatac gacagttgga 3540
gtgtatcgca gaggaacagg ggctgagtga ttacatcaca ggtttgggta gagcttttgg 3600
tgtcgggttc actgaccaaa tctcaacaaa agtcacagaa ctacaagaag tggcgaaaga 3660
tttcctcacc acaaaagttt tgtccaaagt ggtcaaaatg gtttcagctt tagtgatcat 3720
ttgcagaaat catgatgact tggtcactgt tacggccact ctagcactac ttggatgtga 3780
tggatctccc tggagatttc tgaagatgta catttccaaa cactttcagg tgccttacat 3840
tgaaagacaa gcaaatgatg gatggttcag aaagtttaat gatgcatgta atgctgcaaa 3900
gggattggaa tggattgcta ataagatttc caaactgatt gaatggataa aaaacaaagt 3960
acttccccaa gccaaagaaa aactagaatt ttgtagtaaa ctcaaacaac ttgatatact 4020
agagagacaa ataaccacca tgcatatctc gaatccaaca caggaaaaac gagagcagtt 4080
gttcaacaac gtattgtggt tggaacaaat gtcgcaaaag tttgccccac attatgccgt 4140
tgaatcaaaa agaatcaggg aactcaagaa caaaatggta aattatatgc aatttaaaag 4200
taaacaaaga actgaaccag tgtgtgtatt aatccatggt acacccggtt ctggtaaatc 4260
attaacaaca tccattgtgg gacgtgcaat tgcagaacac ttcaattcag cagtatattc 4320
acttccacca gatcccaagc actttgatgg ttatcagcaa caggaagttg tgattatgga 4380
tgatctgaac caaaatccag acggacagga tataagcatg ttttgtcaaa tggtttcttc 4440
agtggatttc ttgcctccaa tggctagttt agataacaag ggcatgttat tcaccagtaa 4500
ttttgttcta gcctccacaa attctaacac actaagcccc ccaacaatct tgaatcctga 4560
agctttagtc aggagatttg gttttgacct ggatatatgt ttgcatacta cctacacaaa 4620
gaatggaaaa ctcaatgcag gcatgtcaac caagacatgc aaagattgcc atcaaccatc 4680
taatttcaag aaatgttgcc ccctggtctg tggaaaagct attagcttgg tagacagaac 4740
taccaacgtt aggtatagtg tggatcaact ggtcacagct attataagtg atttcaagag 4800
caaaatgcaa attacagatt ccctagaaac actgtttcaa ggaccagtgt ataaagattt 4860
agagattgat gtttgcaaca caccacctcc agaatgtatc aacgatttac tgaaatctgt 4920
agattcagaa gagattaggg aatattgtaa gaagaagaaa tggattatac ctgaaattcc 4980
taccaacata gaaagagcta tgaatcaagc cagcatgatt attaatacta ttctgatgtt 5040
tgtcagtaca ttaggtattg tttatgtcat ttataaattg tttgctcaaa ctcaaggacc 5100
atattctggt aacccgcctc acaataaact aaaagcccca actttacgcc cagttgttgt 5160
gcaaggacca aacacagaat ttgcactatc cctgttaagg aaaaacataa tgactataac 5220
aacctcaaag ggagagttca cagggttagg catacatgat cgtgtctgtg tgatacccac 5280
acacgcacag cctggtgatg atgtactagt gaatggtcag aaaattagag ttaaggataa 5340
gtacaaatta gtagatccag agaacattaa tctagagctt acagtgttga ctttagatag 5400
aaatgaaaaa ttcagagata tcaggggatt tatatcagaa gatctagaag gtgtggatgc 5460
cactttggta gtacattcaa ataactttac caacactatc ttagaagttg gccctgtaac 5520
aatggcagga cttattaatt tgagtagcac ccccactaac agaatgattc gttatgatta 5580
tgcaacaaaa actgggcagt gtggaggtgt gctgtgtgct actggtaaga tctttggtat 5640
tcatgttggc ggtaatggaa gacaaggatt ttcagctcaa cttaaaaaac aatattttgt 5700
agagaaacaa ggccaagtaa tagctagaca taaggttagg gagtttaaca taaatccagt 5760
caacacgcca accaagtcaa aattacatcc cagtgtattc tatgatgttt tcccaggtga 5820
caaggaacct gctgtattga gtgacaatga tcccagactg gaagttaaat tgactgaatc 5880
attattctct aagtacaagg ggaatgtaaa tacggaaccc actgaaaata tgcttgtggc 5940
tgtagaccat tatgcagggc aactattatc actagatatc cccacttctg aacttacact 6000
aaaagaagca ttatatggag tagatggact agaacctata gatattacaa ccagtgcagg 6060
atttccctat gtgagtcttg ggatcaaaaa gagagacatt ctgaataaag agacccagga 6120
cacagaaaag atgaagtttt atctagacaa gtatggcatt gacttgcctc tagttacata 6180
tattaaggat gaattaagaa gtgttgacaa agtccgatta gggaaaagta gattaattga 6240
agcctccagt ttgaatgatt ctgttaacat gagaatgaaa ctaggcaacc tttacaaagc 6300
attccatcaa aatcccggtg ttctgactgg atcagcagtg ggttgtgatc ctgatgtgtt 6360
ttggtctgtc atcccttgct taatggatgg gcacctgatg gcatttgatt actctaattt 6420
tgatgcctct ttgtcaccag tttggtttgt ctgtctagag aaggttttga ccaagttagg 6480
ctttgcaggc tcttcattaa ttcaatcaat ttgtaatacc catcatatct ttagggatga 6540
aatatatgtg gttgaaggtg gcatgccctc agggtgttca ggaaccagca tattcaattc 6600
catgatcaac aacataatca ttaggacttt gatattagat gcatataaag gaatagattt 6660
agacaaactt aaaatcttag cttacggtga tgatttgatt gtttcttatc cttatgaact 6720
ggatccgcaa gtgttggcaa ctcttggtaa aaattatgga ctaaccatca cacccccaga 6780
caaatctgaa acttttacaa aaatgacatg ggaaaacttg acatttttaa agagatactt 6840
caagcctgat caacaatttc cctttttggt tcacccagtt atgcccatga aagatataca 6900
tgagtcaatc agatggacaa aggatcctaa aaacacacag gatcacgtcc gatcattatg 6960
catgttagca tggcactcag gagaaaaaga gtacaatgaa ttcattcaga agatcagaac 7020
tactgacatt ggaaaatgtc taattctccc agaatacagc gtacttagga ggcgctggtt 7080
ggacctcttt taggttaaca atatagacac ttaatttgag tagaagtagg agtttataaa 7140
aaaaaaaa 7148
<210> 80
<211> 7171
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 80
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat taccagactg cggtgggatt 3480
ttgagatgca tacatggtcc cattggattg ttaacagctg gaggtagtgg atatgtttgt 3540
tttgctgaca tacgacagtt ggagtgtatc gcagaggaac aggggctgag tgattacatc 3600
acaggtttgg gtagagcttt tggtgtcggg ttcactgacc aaatctcaac aaaagtcaca 3660
gaactacaag aagtggcgaa agatttcctc accacaaaag ttttgtccaa agtggtcaaa 3720
atggtttcag ctttagtgat catttgcaga aatcatgatg acttggtcac tgttacggcc 3780
actctagcac tacttggatg tgatggatct ccctggagat ttctgaagat gtacatttcc 3840
aaacactttc aggtgcctta cattgaaaga caagcaaatg atggatggtt cagaaagttt 3900
aatgatgcat gtaatgctgc aaagggattg gaatggattg ctaataagat ttccaaactg 3960
attgaatgga taaaaaacaa agtacttccc caagccaaag aaaaactaga attttgtagt 4020
aaactcaaac aacttgatat actagagaga caaataacca ccatgcatat ctcgaatcca 4080
acacaggaaa aacgagagca gttgttcaac aacgtattgt ggttggaaca aatgtcgcaa 4140
aagtttgccc cacattatgc cgttgaatca aaaagaatca gggaactcaa gaacaaaatg 4200
gtaaattata tgcaatttaa aagtaaacaa agaactgaac cagtgtgtgt attaatccat 4260
ggtacacccg gttctggtaa atcattaaca acatccattg tgggacgtgc aattgcagaa 4320
cacttcaatt cagcagtata ttcacttcca ccagatccca agcactttga tggttatcag 4380
caacaggaag ttgtgattat ggatgatctg aaccaaaatc cagacggaca ggatataagc 4440
atgttttgtc aaatggtttc ttcagtggat ttcttgcctc caatggctag tttagataac 4500
aagggcatgt tattcaccag taattttgtt ctagcctcca caaattctaa cacactaagc 4560
cccccaacaa tcttgaatcc tgaagcttta gtcaggagat ttggttttga cctggatata 4620
tgtttgcata ctacctacac aaagaatgga aaactcaatg caggcatgtc aaccaagaca 4680
tgcaaagatt gccatcaacc atctaatttc aagaaatgtt gccccctggt ctgtggaaaa 4740
gctattagct tggtagacag aactaccaac gttaggtata gtgtggatca actggtcaca 4800
gctattataa gtgatttcaa gagcaaaatg caaattacag attccctaga aacactgttt 4860
caaggaccag tgtataaaga tttagagatt gatgtttgca acacaccacc tccagaatgt 4920
atcaacgatt tactgaaatc tgtagattca gaagagatta gggaatattg taagaagaag 4980
aaatggatta tacctgaaat tcctaccaac atagaaagag ctatgaatca agccagcatg 5040
attattaata ctattctgat gtttgtcagt acattaggta ttgtttatgt catttataaa 5100
ttgtttgctc aaactcaagg accatattct ggtaacccgc ctcacaataa actaaaagcc 5160
ccaactttac gcccagttgt tgtgcaagga ccaaacacag aatttgcact atccctgtta 5220
aggaaaaaca taatgactat aacaacctca aagggagagt tcacagggtt aggcatacat 5280
gatcgtgtct gtgtgatacc cacacacgca cagcctggtg atgatgtact agtgaatggt 5340
cagaaaatta gagttaagga taagtacaaa ttagtagatc cagagaacat taatctagag 5400
cttacagtgt tgactttaga tagaaatgaa aaattcagag atatcagggg atttatatca 5460
gaagatctag aaggtgtgga tgccactttg gtagtacatt caaataactt taccaacact 5520
atcttagaag ttggccctgt aacaatggca ggacttatta atttgagtag cacccccact 5580
aacagaatga ttcgttatga ttatgcaaca aaaactgggc agtgtggagg tgtgctgtgt 5640
gctactggta agatctttgg tattcatgtt ggcggtaatg gaagacaagg attttcagct 5700
caacttaaaa aacaatattt tgtagagaaa caaggccaag taatagctag acataaggtt 5760
agggagttta acataaatcc agtcaacacg ccaaccaagt caaaattaca tcccagtgta 5820
ttctatgatg ttttcccagg tgacaaggaa cctgctgtat tgagtgacaa tgatcccaga 5880
ctggaagtta aattgactga atcattattc tctaagtaca aggggaatgt aaatacggaa 5940
cccactgaaa atatgcttgt ggctgtagac cattatgcag ggcaactatt atcactagat 6000
atccccactt ctgaacttac actaaaagaa gcattatatg gagtagatgg actagaacct 6060
atagatatta caaccagtgc aggatttccc tatgtgagtc ttgggatcaa aaagagagac 6120
attctgaata aagagaccca ggacacagaa aagatgaagt tttatctaga caagtatggc 6180
attgacttgc ctctagttac atatattaag gatgaattaa gaagtgttga caaagtccga 6240
ttagggaaaa gtagattaat tgaagcctcc agtttgaatg attctgttaa catgagaatg 6300
aaactaggca acctttacaa agcattccat caaaatcccg gtgttctgac tggatcagca 6360
gtgggttgtg atcctgatgt gttttggtct gtcatccctt gcttaatgga tgggcacctg 6420
atggcatttg attactctaa ttttgatgcc tctttgtcac cagtttggtt tgtctgtcta 6480
gagaaggttt tgaccaagtt aggctttgca ggctcttcat taattcaatc aatttgtaat 6540
acccatcata tctttaggga tgaaatatat gtggttgaag gtggcatgcc ctcagggtgt 6600
tcaggaacca gcatattcaa ttccatgatc aacaacataa tcattaggac tttgatatta 6660
gatgcatata aaggaataga tttagacaaa cttaaaatct tagcttacgg tgatgatttg 6720
attgtttctt atccttatga actggatccg caagtgttgg caactcttgg taaaaattat 6780
ggactaacca tcacaccccc agacaaatct gaaactttta caaaaatgac atgggaaaac 6840
ttgacatttt taaagagata cttcaagcct gatcaacaat ttcccttttt ggttcaccca 6900
gttatgccca tgaaagatat acatgagtca atcagatgga caaaggatcc taaaaacaca 6960
caggatcacg tccgatcatt atgcatgtta gcatggcact caggagaaaa agagtacaat 7020
gaattcattc agaagatcag aactactgac attggaaaat gtctaattct cccagaatac 7080
agcgtactta ggaggcgctg gttggacctc ttttaggtta acaatataga cacttaattt 7140
gagtagaagt aggagtttat aaaaaaaaaa a 7171
<210> 81
<211> 7165
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 81
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga agatttctga agatgtacat ttccaaacac 3840
tttcaggtgc cttacattga aagacaagca aatgatggat ggttcagaaa gtttaatgat 3900
gcatgtaatg ctgcaaaggg attggaatgg attgctaata agatttccaa actgattgaa 3960
tggataaaaa acaaagtact tccccaagcc aaagaaaaac tagaattttg tagtaaactc 4020
aaacaacttg atatactaga gagacaaata accaccatgc atatctcgaa tccaacacag 4080
gaaaaacgag agcagttgtt caacaacgta ttgtggttgg aacaaatgtc gcaaaagttt 4140
gccccacatt atgccgttga atcaaaaaga atcagggaac tcaagaacaa aatggtaaat 4200
tatatgcaat ttaaaagtaa acaaagaact gaaccagtgt gtgtattaat ccatggtaca 4260
cccggttctg gtaaatcatt aacaacatcc attgtgggac gtgcaattgc agaacacttc 4320
aattcagcag tatattcact tccaccagat cccaagcact ttgatggtta tcagcaacag 4380
gaagttgtga ttatggatga tctgaaccaa aatccagacg gacaggatat aagcatgttt 4440
tgtcaaatgg tttcttcagt ggatttcttg cctccaatgg ctagtttaga taacaagggc 4500
atgttattca ccagtaattt tgttctagcc tccacaaatt ctaacacact aagcccccca 4560
acaatcttga atcctgaagc tttagtcagg agatttggtt ttgacctgga tatatgtttg 4620
catactacct acacaaagaa tggaaaactc aatgcaggca tgtcaaccaa gacatgcaaa 4680
gattgccatc aaccatctaa tttcaagaaa tgttgccccc tggtctgtgg aaaagctatt 4740
agcttggtag acagaactac caacgttagg tatagtgtgg atcaactggt cacagctatt 4800
ataagtgatt tcaagagcaa aatgcaaatt acagattccc tagaaacact gtttcaagga 4860
ccagtgtata aagatttaga gattgatgtt tgcaacacac cacctccaga atgtatcaac 4920
gatttactga aatctgtaga ttcagaagag attagggaat attgtaagaa gaagaaatgg 4980
attatacctg aaattcctac caacatagaa agagctatga atcaagccag catgattatt 5040
aatactattc tgatgtttgt cagtacatta ggtattgttt atgtcattta taaattgttt 5100
gctcaaactc aaggaccata ttctggtaac ccgcctcaca ataaactaaa agccccaact 5160
ttacgcccag ttgttgtgca aggaccaaac acagaatttg cactatccct gttaaggaaa 5220
aacataatga ctataacaac ctcaaaggga gagttcacag ggttaggcat acatgatcgt 5280
gtctgtgtga tacccacaca cgcacagcct ggtgatgatg tactagtgaa tggtcagaaa 5340
attagagtta aggataagta caaattagta gatccagaga acattaatct agagcttaca 5400
gtgttgactt tagatagaaa tgaaaaattc agagatatca ggggatttat atcagaagat 5460
ctagaaggtg tggatgccac tttggtagta cattcaaata actttaccaa cactatctta 5520
gaagttggcc ctgtaacaat ggcaggactt attaatttga gtagcacccc cactaacaga 5580
atgattcgtt atgattatgc aacaaaaact gggcagtgtg gaggtgtgct gtgtgctact 5640
ggtaagatct ttggtattca tgttggcggt aatggaagac aaggattttc agctcaactt 5700
aaaaaacaat attttgtaga gaaacaaggc caagtaatag ctagacataa ggttagggag 5760
tttaacataa atccagtcaa cacgccaacc aagtcaaaat tacatcccag tgtattctat 5820
gatgttttcc caggtgacaa ggaacctgct gtattgagtg acaatgatcc cagactggaa 5880
gttaaattga ctgaatcatt attctctaag tacaagggga atgtaaatac ggaacccact 5940
gaaaatatgc ttgtggctgt agaccattat gcagggcaac tattatcact agatatcccc 6000
acttctgaac ttacactaaa agaagcatta tatggagtag atggactaga acctatagat 6060
attacaacca gtgcaggatt tccctatgtg agtcttggga tcaaaaagag agacattctg 6120
aataaagaga cccaggacac agaaaagatg aagttttatc tagacaagta tggcattgac 6180
ttgcctctag ttacatatat taaggatgaa ttaagaagtg ttgacaaagt ccgattaggg 6240
aaaagtagat taattgaagc ctccagtttg aatgattctg ttaacatgag aatgaaacta 6300
ggcaaccttt acaaagcatt ccatcaaaat cccggtgttc tgactggatc agcagtgggt 6360
tgtgatcctg atgtgttttg gtctgtcatc ccttgcttaa tggatgggca cctgatggca 6420
tttgattact ctaattttga tgcctctttg tcaccagttt ggtttgtctg tctagagaag 6480
gttttgacca agttaggctt tgcaggctct tcattaattc aatcaatttg taatacccat 6540
catatcttta gggatgaaat atatgtggtt gaaggtggca tgccctcagg gtgttcagga 6600
accagcatat tcaattccat gatcaacaac ataatcatta ggactttgat attagatgca 6660
tataaaggaa tagatttaga caaacttaaa atcttagctt acggtgatga tttgattgtt 6720
tcttatcctt atgaactgga tccgcaagtg ttggcaactc ttggtaaaaa ttatggacta 6780
accatcacac ccccagacaa atctgaaact tttacaaaaa tgacatggga aaacttgaca 6840
tttttaaaga gatacttcaa gcctgatcaa caatttccct ttttggttca cccagttatg 6900
cccatgaaag atatacatga gtcaatcaga tggacaaagg atcctaaaaa cacacaggat 6960
cacgtccgat cattatgcat gttagcatgg cactcaggag aaaaagagta caatgaattc 7020
attcagaaga tcagaactac tgacattgga aaatgtctaa ttctcccaga atacagcgta 7080
cttaggaggc gctggttgga cctcttttag gttaacaata tagacactta atttgagtag 7140
aagtaggagt ttataaaaaa aaaaa 7165
<210> 82
<211> 7181
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 82
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttctggattg ctaataagat 3960
ttccaaactg attgaatgga taaaaaacaa agtacttccc caagccaaag aaaaactaga 4020
attttgtagt aaactcaaac aacttgatat actagagaga caaataacca ccatgcatat 4080
ctcgaatcca acacaggaaa aacgagagca gttgttcaac aacgtattgt ggttggaaca 4140
aatgtcgcaa aagtttgccc cacattatgc cgttgaatca aaaagaatca gggaactcaa 4200
gaacaaaatg gtaaattata tgcaatttaa aagtaaacaa agaactgaac cagtgtgtgt 4260
attaatccat ggtacacccg gttctggtaa atcattaaca acatccattg tgggacgtgc 4320
aattgcagaa cacttcaatt cagcagtata ttcacttcca ccagatccca agcactttga 4380
tggttatcag caacaggaag ttgtgattat ggatgatctg aaccaaaatc cagacggaca 4440
ggatataagc atgttttgtc aaatggtttc ttcagtggat ttcttgcctc caatggctag 4500
tttagataac aagggcatgt tattcaccag taattttgtt ctagcctcca caaattctaa 4560
cacactaagc cccccaacaa tcttgaatcc tgaagcttta gtcaggagat ttggttttga 4620
cctggatata tgtttgcata ctacctacac aaagaatgga aaactcaatg caggcatgtc 4680
aaccaagaca tgcaaagatt gccatcaacc atctaatttc aagaaatgtt gccccctggt 4740
ctgtggaaaa gctattagct tggtagacag aactaccaac gttaggtata gtgtggatca 4800
actggtcaca gctattataa gtgatttcaa gagcaaaatg caaattacag attccctaga 4860
aacactgttt caaggaccag tgtataaaga tttagagatt gatgtttgca acacaccacc 4920
tccagaatgt atcaacgatt tactgaaatc tgtagattca gaagagatta gggaatattg 4980
taagaagaag aaatggatta tacctgaaat tcctaccaac atagaaagag ctatgaatca 5040
agccagcatg attattaata ctattctgat gtttgtcagt acattaggta ttgtttatgt 5100
catttataaa ttgtttgctc aaactcaagg accatattct ggtaacccgc ctcacaataa 5160
actaaaagcc ccaactttac gcccagttgt tgtgcaagga ccaaacacag aatttgcact 5220
atccctgtta aggaaaaaca taatgactat aacaacctca aagggagagt tcacagggtt 5280
aggcatacat gatcgtgtct gtgtgatacc cacacacgca cagcctggtg atgatgtact 5340
agtgaatggt cagaaaatta gagttaagga taagtacaaa ttagtagatc cagagaacat 5400
taatctagag cttacagtgt tgactttaga tagaaatgaa aaattcagag atatcagggg 5460
atttatatca gaagatctag aaggtgtgga tgccactttg gtagtacatt caaataactt 5520
taccaacact atcttagaag ttggccctgt aacaatggca ggacttatta atttgagtag 5580
cacccccact aacagaatga ttcgttatga ttatgcaaca aaaactgggc agtgtggagg 5640
tgtgctgtgt gctactggta agatctttgg tattcatgtt ggcggtaatg gaagacaagg 5700
attttcagct caacttaaaa aacaatattt tgtagagaaa caaggccaag taatagctag 5760
acataaggtt agggagttta acataaatcc agtcaacacg ccaaccaagt caaaattaca 5820
tcccagtgta ttctatgatg ttttcccagg tgacaaggaa cctgctgtat tgagtgacaa 5880
tgatcccaga ctggaagtta aattgactga atcattattc tctaagtaca aggggaatgt 5940
aaatacggaa cccactgaaa atatgcttgt ggctgtagac cattatgcag ggcaactatt 6000
atcactagat atccccactt ctgaacttac actaaaagaa gcattatatg gagtagatgg 6060
actagaacct atagatatta caaccagtgc aggatttccc tatgtgagtc ttgggatcaa 6120
aaagagagac attctgaata aagagaccca ggacacagaa aagatgaagt tttatctaga 6180
caagtatggc attgacttgc ctctagttac atatattaag gatgaattaa gaagtgttga 6240
caaagtccga ttagggaaaa gtagattaat tgaagcctcc agtttgaatg attctgttaa 6300
catgagaatg aaactaggca acctttacaa agcattccat caaaatcccg gtgttctgac 6360
tggatcagca gtgggttgtg atcctgatgt gttttggtct gtcatccctt gcttaatgga 6420
tgggcacctg atggcatttg attactctaa ttttgatgcc tctttgtcac cagtttggtt 6480
tgtctgtcta gagaaggttt tgaccaagtt aggctttgca ggctcttcat taattcaatc 6540
aatttgtaat acccatcata tctttaggga tgaaatatat gtggttgaag gtggcatgcc 6600
ctcagggtgt tcaggaacca gcatattcaa ttccatgatc aacaacataa tcattaggac 6660
tttgatatta gatgcatata aaggaataga tttagacaaa cttaaaatct tagcttacgg 6720
tgatgatttg attgtttctt atccttatga actggatccg caagtgttgg caactcttgg 6780
taaaaattat ggactaacca tcacaccccc agacaaatct gaaactttta caaaaatgac 6840
atgggaaaac ttgacatttt taaagagata cttcaagcct gatcaacaat ttcccttttt 6900
ggttcaccca gttatgccca tgaaagatat acatgagtca atcagatgga caaaggatcc 6960
taaaaacaca caggatcacg tccgatcatt atgcatgtta gcatggcact caggagaaaa 7020
agagtacaat gaattcattc agaagatcag aactactgac attggaaaat gtctaattct 7080
cccagaatac agcgtactta ggaggcgctg gttggacctc ttttaggtta acaatataga 7140
cacttaattt gagtagaagt aggagtttat aaaaaaaaaa a 7181
<210> 83
<211> 7187
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 83
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagctat tctgatgttt gtcagtacat taggtattgt 5100
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 5160
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 5220
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 5280
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 5340
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 5400
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5460
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5520
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5580
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5640
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5700
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5760
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5820
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5880
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5940
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 6000
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 6060
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 6120
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 6180
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 6240
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 6300
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 6360
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6420
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6480
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6540
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6600
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6660
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6720
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6780
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6840
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6900
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6960
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 7020
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 7080
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 7140
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 7187
<210> 84
<211> 7182
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 84
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagaaag agctatgaat caagccagca tgattattaa 5100
tactattctg atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc 5160
tcaaactcaa ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt 5220
acgcccagtt gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa 5280
cataatgact ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt 5340
ctgtgtgata cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat 5400
tagagttaag gataagtaca atgactttag atagaaatga aaaattcaga gatatcaggg 5460
gatttatatc agaagatcta gaaggtgtgg atgccacttt ggtagtacat tcaaataact 5520
ttaccaacac tatcttagaa gttggccctg taacaatggc aggacttatt aatttgagta 5580
gcacccccac taacagaatg attcgttatg attatgcaac aaaaactggg cagtgtggag 5640
gtgtgctgtg tgctactggt aagatctttg gtattcatgt tggcggtaat ggaagacaag 5700
gattttcagc tcaacttaaa aaacaatatt ttgtagagaa acaaggccaa gtaatagcta 5760
gacataaggt tagggagttt aacataaatc cagtcaacac gccaaccaag tcaaaattac 5820
atcccagtgt attctatgat gttttcccag gtgacaagga acctgctgta ttgagtgaca 5880
atgatcccag actggaagtt aaattgactg aatcattatt ctctaagtac aaggggaatg 5940
taaatacgga acccactgaa aatatgcttg tggctgtaga ccattatgca gggcaactat 6000
tatcactaga tatccccact tctgaactta cactaaaaga agcattatat ggagtagatg 6060
gactagaacc tatagatatt acaaccagtg caggatttcc ctatgtgagt cttgggatca 6120
aaaagagaga cattctgaat aaagagaccc aggacacaga aaagatgaag ttttatctag 6180
acaagtatgg cattgacttg cctctagtta catatattaa ggatgaatta agaagtgttg 6240
acaaagtccg attagggaaa agtagattaa ttgaagcctc cagtttgaat gattctgtta 6300
acatgagaat gaaactaggc aacctttaca aagcattcca tcaaaatccc ggtgttctga 6360
ctggatcagc agtgggttgt gatcctgatg tgttttggtc tgtcatccct tgcttaatgg 6420
atgggcacct gatggcattt gattactcta attttgatgc ctctttgtca ccagtttggt 6480
ttgtctgtct agagaaggtt ttgaccaagt taggctttgc aggctcttca ttaattcaat 6540
caatttgtaa tacccatcat atctttaggg atgaaatata tgtggttgaa ggtggcatgc 6600
cctcagggtg ttcaggaacc agcatattca attccatgat caacaacata atcattagga 6660
ctttgatatt agatgcatat aaaggaatag atttagacaa acttaaaatc ttagcttacg 6720
gtgatgattt gattgtttct tatccttatg aactggatcc gcaagtgttg gcaactcttg 6780
gtaaaaatta tggactaacc atcacacccc cagacaaatc tgaaactttt acaaaaatga 6840
catgggaaaa cttgacattt ttaaagagat acttcaagcc tgatcaacaa tttccctttt 6900
tggttcaccc agttatgccc atgaaagata tacatgagtc aatcagatgg acaaaggatc 6960
ctaaaaacac acaggatcac gtccgatcat tatgcatgtt agcatggcac tcaggagaaa 7020
aagagtacaa tgaattcatt cagaagatca gaactactga cattggaaaa tgtctaattc 7080
tcccagaata cagcgtactt aggaggcgct ggttggacct cttttaggtt aacaatatag 7140
acacttaatt tgagtagaag taggagttta taaaaaaaaa aa 7182
<210> 85
<211> 7176
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 85
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagaaag agctatgaat caagccagca tgattattaa 5100
tactattctg atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc 5160
tcaaactcaa ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt 5220
acgcccagtt gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa 5280
cataatgact ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt 5340
ctgtgtgata cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat 5400
tagagttaag gataagtaca aattagtaga tccagagaac attaatctag agcttacagt 5460
gttgacttta gatagaaatg aaaaattcag agatatcagg ggatttatat cagaagatct 5520
agaaggtgtg gatgccactt tggtagtaca ttcaaataac tttaccaaca ctatcttaga 5580
agttggccct gtaacaatgg caggacttat taatttgagt agcaccccca ctaacagaat 5640
gattcgttat gattatgcaa caaaaactgg gcagtgtgga ggtgtgctgt gtgctactgg 5700
taagatcttt ggtattcatg ttggcggtaa tggaagacaa ggattttcag ctcaacttaa 5760
aaaacaatat tttgtagaga aacaaggcca agtaatagct agacataagg ttagggagtt 5820
taacataaat ccagtcaaca cgccaaccaa gtcaaaatta catcccagtg tattctatga 5880
tgttttccca ggtgacaagg aacctgctgt attgagtgac aatgatccca gactggaagt 5940
taaattgact gaatcattat tctctaagta caaggggaat gtaaatacgg aacccactga 6000
aaatatgctt gtggctgtag accattatgc agggcaacta ttatcactag atatccccac 6060
ttctgaactt acactaaaag aagcattata tggagtagat ggactagaac ctatagatat 6120
tacaacttct gaataaagag acccaggaca cagaaaagat gaagttttat ctagacaagt 6180
atggcattga cttgcctcta gttacatata ttaaggatga attaagaagt gttgacaaag 6240
tccgattagg gaaaagtaga ttaattgaag cctccagttt gaatgattct gttaacatga 6300
gaatgaaact aggcaacctt tacaaagcat tccatcaaaa tcccggtgtt ctgactggat 6360
cagcagtggg ttgtgatcct gatgtgtttt ggtctgtcat cccttgctta atggatgggc 6420
acctgatggc atttgattac tctaattttg atgcctcttt gtcaccagtt tggtttgtct 6480
gtctagagaa ggttttgacc aagttaggct ttgcaggctc ttcattaatt caatcaattt 6540
gtaataccca tcatatcttt agggatgaaa tatatgtggt tgaaggtggc atgccctcag 6600
ggtgttcagg aaccagcata ttcaattcca tgatcaacaa cataatcatt aggactttga 6660
tattagatgc atataaagga atagatttag acaaacttaa aatcttagct tacggtgatg 6720
atttgattgt ttcttatcct tatgaactgg atccgcaagt gttggcaact cttggtaaaa 6780
attatggact aaccatcaca cccccagaca aatctgaaac ttttacaaaa atgacatggg 6840
aaaacttgac atttttaaag agatacttca agcctgatca acaatttccc tttttggttc 6900
acccagttat gcccatgaaa gatatacatg agtcaatcag atggacaaag gatcctaaaa 6960
acacacagga tcacgtccga tcattatgca tgttagcatg gcactcagga gaaaaagagt 7020
acaatgaatt cattcagaag atcagaacta ctgacattgg aaaatgtcta attctcccag 7080
aatacagcgt acttaggagg cgctggttgg acctctttta ggttaacaat atagacactt 7140
aatttgagta gaagtaggag tttataaaaa aaaaaa 7176
<210> 86
<211> 6674
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 86
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagaaag agctatgaat caagccagca tgattattaa 5100
tactattctg atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc 5160
tcaaactcaa ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt 5220
acgcccagtt gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa 5280
cataatgact ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt 5340
ctgtgtgata cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat 5400
tagagttaag gataagtaca aattagtaga tccagagaac attaatctag agcttacagt 5460
gttgacttta gatagaaatg aaaaattcag agatatcagg ggatttatat cagaagatct 5520
agaaggtgtg gatgccactt tggtagtaca ttcaaataac tttaccaaca ctatcttaga 5580
agttggccct gtaacaatgg caggacttat taatttgagt agcaccccca ctaacagaat 5640
gattcgttat gattatgcaa caaaaactgg gcagtgtgga ggtgtgctgt gtgctactgg 5700
taagatcttt ggtattcatg ttggcggtaa tggaagacaa ggattttcag ctcaacttaa 5760
aaaacaatat tttgtagaga aacaaggcca agtaatagct agacataagg ttagggagtt 5820
taacataaat ccagtcaaca cgccaaccaa gtcaaaatta catcccagtg tattctatga 5880
tgttttccca ggtgacaagg aacctgctgt attgagtgac aatgatccca gactggaagt 5940
taaattgact gaatcattat tctctaagta caaggggaat gtaaatacgg aacccactga 6000
aaatatgctt gtggctgtag accattatgc agggcaacta ttatcactag atatccccac 6060
ttctgaactt acactaaaag aagcattata tggagtagat ggactagaac ctatagatat 6120
tacaaccagt gcaggatttc cctatgtgag tcttgggatc aaaaagagag acattctgaa 6180
taaagagacc caggacacag aaaagatgaa gttttatcta gacaagtatg gcattgactt 6240
gcctctagtt acatatatta aggatgaatt aagaagtgtt gacaaagtcc gattagggaa 6300
aagtagatta attgaagcct ccagtttgaa tgattctgtt aacatgagaa tgaaactagg 6360
caacctttac aaagcattcc atcaaaatcc cggtgttctg actggatcag cagtgggttg 6420
tgatcctgat gtgttttggt ctgtaaagga tcctaaaaac acacaggatc acgtccgatc 6480
attatgcatg ttagcatggc actcaggaga aaaagagtac aatgaattca ttcagaagat 6540
cagaactact gacattggaa aatgtctaat tctcccagaa tacagcgtac ttaggaggcg 6600
ctggttggac ctcttttagg ttaacaatat agacacttaa tttgagtaga agtaggagtt 6660
tataaaaaaa aaaa 6674
<210> 87
<211> 1106
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 87
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcaa gcttaggctg atgaaagata ctcaaactat 660
ctcacagact gttgcactca ctgaaggctt aggtgatgaa ttagaagaag tcatcgttga 720
gaaaacgaaa cagacggtgg cctcaatctc atctggtcca aaacacacac aaaaagtccc 780
catactaact gcaaacgaaa caggggccac aatgcctgtt cttccatcag acagcataga 840
aaccagaact acctacatgc actttaatgg ttcagaaact gatgtagaat gctttttggg 900
tcgtgcagct tgtgtgcatg taactgaaat acaaaacaaa gatgctactg gaatagataa 960
tcacagagaa gcaaaattgt tcaatgattg gaaaatcaac ctgtccagcc ttgtccaact 1020
tagaaagaaa ctagaactct tcacttatta ggttaacaat atagacactt aatttgagta 1080
gaagtaggag tttataaaaa aaaaaa 1106
<210> 88
<211> 7140
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 88
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaagggttc 2880
agacaacaat gaatatggaa ttgctcccac caatgacatg ggtttgttat gcttcaggac 2940
tttggacaat agtggtggaa atgatgtgaa aatatacgtc aaacccaaac acataacggc 3000
atgggtacca agaccaccaa gggcaacaca gtacacccac aagtacagta caaactacca 3060
ttacaaacct aactctagtg gacctgatga acacgtgctt aaagacagac actttatcaa 3120
aaccagaccc ctcatcagct cagcgggacc gagcgacatg tttgtgcaca caagagatgc 3180
aatttataaa tgtgcacatc taaccaatcc aactgatgaa accatacttc tggcattgac 3240
tgcagatcta caggtggata gtaccaatgt tccaggcccc gatgtgattc cgtgttgtga 3300
ttgcactgct ggttgctact actctagaag caaagacaga tacttcccag tggagtgtgt 3360
tagtcatgac tggtatgaga tacaagaatc tggctactat cccaaacata tacaatataa 3420
tctactcatt ggggaaggac actgtgaacc aggtgactgt ggaggcaagt tactatgcaa 3480
gcatggtgtg attggtatga tcactgcagg tggtgataac catgttgctt tcactgacct 3540
acgcccatac tcaagcttat cagaacacca aggggttatt tcagattact tcacccagtt 3600
gggtaatgca tttggtgagg gcttcacaac caacattcaa gaccactttt cacaaatcac 3660
caagtcaatt tctgacaaat ttacatcaaa ggctattaaa tggttggtgc gcatcataag 3720
cgcccttaca attatgatta gaaacaactc agacttgcct accatacttg ctactctgtc 3780
attgttgggg tgtagtagct caccatggtc tttcctcaag gacaaaatct gcagctggct 3840
tcaaatccag cgtcccgcaa gcaaacagag tgattcatgg ttgcgcaaat tcacagaatg 3900
ttgcaatgca gcaaaaggac ttgaatggat cagtatcaag attggcaagt ttattgattg 3960
gctgaaaggg aaactagtcc ccgctgtcca gaggaaaaga gacaccctag atagatgcaa 4020
gaaaatatct ctcttagaag aacaagtgaa tggattcagt tctgctagct cagaagcaca 4080
acaacaactt attgtagaag tggatactct aaagaagggt ttagatgagc tggcaccatt 4140
gtatgctagt gaaaacaaaa gggtgactaa gattcaaaaa gatctcaaac aactatcagc 4200
ttatctaaag aaccataggc atgaaccagt ttgcttattg ttacatggca acccaggatg 4260
tggaaaatca ctagttacaa ccataatcgc tagaggactc acccaggagg cacaggtata 4320
ctcactacca cctgatccca aatatttcga tggttatgac caacagcagg ttgtcatatt 4380
ggatgatctt ggacaaaatc ctgatggtaa agatttaagc acattctgtc agatggtatc 4440
aacaacagat ttcatagtac ctatggcatc actagaggat aagggtaagt ctttcaccag 4500
ccaatatgtg cttgccagca ctaacctgga cactctgtca ccaccaacag tcacaatacc 4560
tgaggctata aaacggcgat tctttctgga tgccgatctc atcacaacat ctaagttcag 4620
aaataccaca ggactgctag atgtagcaaa ggcactacaa ccatgcacag gttgtcccaa 4680
accagctcac tataaaacgt gctgtcctct gttgtgtggc aaggcagttg tagttcagga 4740
caggaaaaca aaagcaaatt tctcagtgaa cacaatagta gagcagctga ggcatgagaa 4800
tgctaccagg aaaaaggtta aacacaacct tgatgcaata ttccagggtc ttggtgactc 4860
agaaacacca ggttttatag ttgatctgct atcctcatct aaagacccca aagttataga 4920
atattgtgct gaacagggat ggataggtaa agcaaactca accatagaga gggattttaa 4980
ttatgtgcat tacatgttaa attgcttagg tagtctaata attatcttag ggactgtata 5040
tgcactatac aagctgatgt gtatgactca aggaccttac actggcttac caaaccccca 5100
aaccaaaaga ccagagctca ggaaagccac actacagggc cctgagcatg aattcgtcag 5160
ggctttaatt aaaagaaact gccatgtgat aaccacctca aaaggggagt tcaacatgct 5220
tggaatccat gataactgtg cggtggtgcc aacacacgct gaatgtggtg actctgtcac 5280
aattgacggc agggaagtca gggttcttaa acaatgcatt ctcactgaca caaatgacac 5340
agacactgaa ataactctcc tctggttaga tcagaatgaa aaatttaggg acattagaag 5400
gttcatccca gaacaccaac gcgaatggtc aaatatgcat cttgccacaa atgtaactaa 5460
attccccatg ctagatgtgg aggttggcac tgtaatacca tatggagagg tcaacctcag 5520
tggtaaccca acatgtcggc ttctcaagta caactatcct acaaagccag gacaatgtgg 5580
tggtgtcatt gcaaacacag gaaacatagt agcaattcat gttggcggaa atggacgtgt 5640
ggggtatgga gcagcattgc tacgtaagta cttcgcacag tctcaaggtg agatcactgc 5700
caaacatgat gttagagaaa aaggtttgcc acaaattaac acacctaata aaacaaaatt 5760
acaacccagt gtattttatg atgtttttcc aggggtgaag gaaccggcag ccttaagcaa 5820
tggagaccca cggcttgagg ttgatctcag tacatctgtg ttaagtaagt acaaaggtaa 5880
cacacaagtg gaatggaatg ataatatcca gattgcagtt gaccactact cagctcaact 5940
ttacatgtta gacatcaatc ctcaaccatt aaccatggaa caggcagtct atggcataga 6000
gcatctggaa ccactagacc tcaccaccag tgcaggattc ccctatgtaa ctatgggtat 6060
aaagaaaaag gatatagtca acaaagtgac aaaggatgta accaaacttc aggaaatgat 6120
tgacaaatat ggaatagact tgccttatgt cacctatcta aaagatgaat tgagagctcc 6180
tgagaaaatc aagaaaggga aaacgagagc aatagaggca gctagcataa atgacacaac 6240
ccacttccgc atggtgttcg gtaatctctt ttctgtattc catgctaacc caggtgtact 6300
tacaggctct gcagtaggct gtaaccctga tgtgttctgg tctcaaatgt atgcatgtat 6360
ggatggtgag ttgcttgctt ttgattacac aaactatgat ggtagtttgc acccaatctg 6420
gttcaaagca ctaggtaaag tcttagacaa tttgggattc ccaggtcact tagtaaatag 6480
attgtgcaat acaacacaca tctttaaaaa cttgatttat actgtggaag gaggtatgcc 6540
ctctggtatc tgtggcacaa gtattttcaa taccatgatc aataatataa tcattagagt 6600
gttggttctt gaaacataca agaatataga tctggacaag ctaaaaatta tagcatatgg 6660
tgatgatgta gtagtgtcat acccttttga attggatcca atggaaattg ccaataaggc 6720
agtgaggtat gggttaacca tcactccacc agacaagggc agtacatttc ataagattga 6780
ttggacaaat gtcacctttc tcaaaaggca tttcaaacca gacaccaaat acaaatttct 6840
gatacatcca gtatacaaga tggaggacat ctatgaatca attagatgga caaaggaccc 6900
aaagaacaca caagaccatg ttcactcatt gtgtctactt gcatggcaca acggagagga 6960
ggtctatgaa aagtttaggg agaaaatcag atctacaagt gttggtaagg ttctctacac 7020
ccctccttac tcattgttgt acaggcaatg gatagatcaa ttcatataaa caaataatat 7080
aatacaatgt ttgagtagaa cttagtatta taaaaaaaaa aaaaaaaaaa aaaaaaaaaa 7140
<210> 89
<211> 7071
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 89
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaaggacaa 2880
tagtggtgga aatgatgtga aaatatacgt caaacccaaa cacataacgg catgggtacc 2940
aagaccacca agggcaacac agtacaccca caagtacagt acaaactacc attacaaacc 3000
taactctagt ggacctgatg aacacgtgct taaagacaga cactttatca aaaccagacc 3060
cctcatcagc tcagcgggac cgagcgacat gtttgtgcac acaagagatg caatttataa 3120
atgtgcacat ctaaccaatc caactgatga aaccatactt ctggcattga ctgcagatct 3180
acaggtggat agtaccaatg ttccaggccc cgatgtgatt ccgtgttgtg attgcactgc 3240
tggttgctac tactctagaa gcaaagacag atacttccca gtggagtgtg ttagtcatga 3300
ctggtatgag atacaagaat ctggctacta tcccaaacat atacaatata atctactcat 3360
tggggaagga cactgtgaac caggtgactg tggaggcaag ttactatgca agcatggtgt 3420
gattggtatg atcactgcag gtggtgataa ccatgttgct ttcactgacc tacgcccata 3480
ctcaagctta tcagaacacc aaggggttat ttcagattac ttcacccagt tgggtaatgc 3540
atttggtgag ggcttcacaa ccaacattca agaccacttt tcacaaatca ccaagtcaat 3600
ttctgacaaa tttacatcaa aggctattaa atggttggtg cgcatcataa gcgcccttac 3660
aattatgatt agaaacaact cagacttgcc taccatactt gctactctgt cattgttggg 3720
gtgtagtagc tcaccatggt ctttcctcaa ggacaaaatc tgcagctggc ttcaaatcca 3780
gcgtcccgca agcaaacaga gtgattcatg gttgcgcaaa ttcacagaat gttgcaatgc 3840
agcaaaagga cttgaatgga tcagtatcaa gattggcaag tttattgatt ggctgaaagg 3900
gaaactagtc cccgctgtcc agaggaaaag agacacccta gatagatgca agaaaatatc 3960
tctcttagaa gaacaagtga atggattcag ttctgctagc tcagaagcac aacaacaact 4020
tattgtagaa gtggatactc taaagaaggg tttagatgag ctggcaccat tgtatgctag 4080
tgaaaacaaa agggtgacta agattcaaaa agatctcaaa caactatcag cttatctaaa 4140
gaaccatagg catgaaccag tttgcttatt gttacatggc aacccaggat gtggaaaatc 4200
actagttaca accataatcg ctagaggact cacccaggag gcacaggtat actcactacc 4260
acctgatccc aaatatttcg atggttatga ccaacagcag gttgtcatat tggatgatct 4320
tggacaaaat cctgatggta aagatttaag cacattctgt cagatggtat caacaacaga 4380
tttcatagta cctatggcat cactagagga taagggtaag tctttcacca gccaatatgt 4440
gcttgccagc actaacctgg acactctgtc accaccaaca gtcacaatac ctgaggctat 4500
aaaacggcga ttctttctgg atgccgatct catcacaaca tctaagttca gaaataccac 4560
aggactgcta gatgtagcaa aggcactaca accatgcaca ggttgtccca aaccagctca 4620
ctataaaacg tgctgtcctc tgttgtgtgg caaggcagtt gtagttcagg acaggaaaac 4680
aaaagcaaat ttctcagtga acacaatagt agagcagctg aggcatgaga atgctaccag 4740
gaaaaaggtt aaacacaacc ttgatgcaat attccagggt cttggtgact cagaaacacc 4800
aggttttata gttgatctgc tatcctcatc taaagacccc aaagttatag aatattgtgc 4860
tgaacaggga tggataggta aagcaaactc aaccatagag agggatttta attatgtgca 4920
ttacatgtta aattgcttag gtagtctaat aattatctta gggactgtat atgcactata 4980
caagctgatg tgtatgactc aaggacctta cactggctta ccaaaccccc aaaccaaaag 5040
accagagctc aggaaagcca cactacaggg ccctgagcat gaattcgtca gggctttaat 5100
taaaagaaac tgccatgtga taaccacctc aaaaggggag ttcaacatgc ttggaatcca 5160
tgataactgt gcggtggtgc caacacacgc tgaatgtggt gactctgtca caattgacgg 5220
cagggaagtc agggttctta aacaatgcat tctcactgac acaaatgaca cagacactga 5280
aataactctc ctctggttag atcagaatga aaaatttagg gacattagaa ggttcatccc 5340
agaacaccaa cgcgaatggt caaatatgca tcttgccaca aatgtaacta aattccccat 5400
gctagatgtg gaggttggca ctgtaatacc atatggagag gtcaacctca gtggtaaccc 5460
aacatgtcgg cttctcaagt acaactatcc tacaaagcca ggacaatgtg gtggtgtcat 5520
tgcaaacaca ggaaacatag tagcaattca tgttggcgga aatggacgtg tggggtatgg 5580
agcagcattg ctacgtaagt acttcgcaca gtctcaaggt gagatcactg ccaaacatga 5640
tgttagagaa aaaggtttgc cacaaattaa cacacctaat aaaacaaaat tacaacccag 5700
tgtattttat gatgtttttc caggggtgaa ggaaccggca gccttaagca atggagaccc 5760
acggcttgag gttgatctca gtacatctgt gttaagtaag tacaaaggta acacacaagt 5820
ggaatggaat gataatatcc agattgcagt tgaccactac tcagctcaac tttacatgtt 5880
agacatcaat cctcaaccat taaccatgga acaggcagtc tatggcatag agcatctgga 5940
accactagac ctcaccacca gtgcaggatt cccctatgta actatgggta taaagaaaaa 6000
ggatatagtc aacaaagtga caaaggatgt aaccaaactt caggaaatga ttgacaaata 6060
tggaatagac ttgccttatg tcacctatct aaaagatgaa ttgagagctc ctgagaaaat 6120
caagaaaggg aaaacgagag caatagaggc agctagcata aatgacacaa cccacttccg 6180
catggtgttc ggtaatctct tttctgtatt ccatgctaac ccaggtgtac ttacaggctc 6240
tgcagtaggc tgtaaccctg atgtgttctg gtctcaaatg tatgcatgta tggatggtga 6300
gttgcttgct tttgattaca caaactatga tggtagtttg cacccaatct ggttcaaagc 6360
actaggtaaa gtcttagaca atttgggatt cccaggtcac ttagtaaata gattgtgcaa 6420
tacaacacac atctttaaaa acttgattta tactgtggaa ggaggtatgc cctctggtat 6480
ctgtggcaca agtattttca ataccatgat caataatata atcattagag tgttggttct 6540
tgaaacatac aagaatatag atctggacaa gctaaaaatt atagcatatg gtgatgatgt 6600
agtagtgtca tacccttttg aattggatcc aatggaaatt gccaataagg cagtgaggta 6660
tgggttaacc atcactccac cagacaaggg cagtacattt cataagattg attggacaaa 6720
tgtcaccttt ctcaaaaggc atttcaaacc agacaccaaa tacaaatttc tgatacatcc 6780
agtatacaag atggaggaca tctatgaatc aattagatgg acaaaggacc caaagaacac 6840
acaagaccat gttcactcat tgtgtctact tgcatggcac aacggagagg aggtctatga 6900
aaagtttagg gagaaaatca gatctacaag tgttggtaag gttctctaca cccctcctta 6960
ctcattgttg tacaggcaat ggatagatca attcatataa acaaataata taatacaatg 7020
tttgagtaga acttagtatt ataaaaaaaa aaaaaaaaaa aaaaaaaaaa a 7071
<210> 90
<211> 7070
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 90
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaagacaat 2880
agtggtggaa atgatgtgaa aatatacgtc aaacccaaac acataacggc atgggtacca 2940
agaccaccaa gggcaacaca gtacacccac aagtacagta caaactacca ttacaaacct 3000
aactctagtg gacctgatga acacgtgctt aaagacagac actttatcaa aaccagaccc 3060
ctcatcagct cagcgggacc gagcgacatg tttgtgcaca caagagatgc aatttataaa 3120
tgtgcacatc taaccaatcc aactgatgaa accatacttc tggcattgac tgcagatcta 3180
caggtggata gtaccaatgt tccaggcccc gatgtgattc cgtgttgtga ttgcactgct 3240
ggttgctact actctagaag caaagacaga tacttcccag tggagtgtgt tagtcatgac 3300
tggtatgaga tacaagaatc tggctactat cccaaacata tacaatataa tctactcatt 3360
ggggaaggac actgtgaacc aggtgactgt ggaggcaagt tactatgcaa gcatggtgtg 3420
attggtatga tcactgcagg tggtgataac catgttgctt tcactgacct acgcccatac 3480
tcaagcttat cagaacacca aggggttatt tcagattact tcacccagtt gggtaatgca 3540
tttggtgagg gcttcacaac caacattcaa gaccactttt cacaaatcac caagtcaatt 3600
tctgacaaat ttacatcaaa ggctattaaa tggttggtgc gcatcataag cgcccttaca 3660
attatgatta gaaacaactc agacttgcct accatacttg ctactctgtc attgttgggg 3720
tgtagtagct caccatggtc tttcctcaag gacaaaatct gcagctggct tcaaatccag 3780
cgtcccgcaa gcaaacagag tgattcatgg ttgcgcaaat tcacagaatg ttgcaatgca 3840
gcaaaaggac ttgaatggat cagtatcaag attggcaagt ttattgattg gctgaaaggg 3900
aaactagtcc ccgctgtcca gaggaaaaga gacaccctag atagatgcaa gaaaatatct 3960
ctcttagaag aacaagtgaa tggattcagt tctgctagct cagaagcaca acaacaactt 4020
attgtagaag tggatactct aaagaagggt ttagatgagc tggcaccatt gtatgctagt 4080
gaaaacaaaa gggtgactaa gattcaaaaa gatctcaaac aactatcagc ttatctaaag 4140
aaccataggc atgaaccagt ttgcttattg ttacatggca acccaggatg tggaaaatca 4200
ctagttacaa ccataatcgc tagaggactc acccaggagg cacaggtata ctcactacca 4260
cctgatccca aatatttcga tggttatgac caacagcagg ttgtcatatt ggatgatctt 4320
ggacaaaatc ctgatggtaa agatttaagc acattctgtc agatggtatc aacaacagat 4380
ttcatagtac ctatggcatc actagaggat aagggtaagt ctttcaccag ccaatatgtg 4440
cttgccagca ctaacctgga cactctgtca ccaccaacag tcacaatacc tgaggctata 4500
aaacggcgat tctttctgga tgccgatctc atcacaacat ctaagttcag aaataccaca 4560
ggactgctag atgtagcaaa ggcactacaa ccatgcacag gttgtcccaa accagctcac 4620
tataaaacgt gctgtcctct gttgtgtggc aaggcagttg tagttcagga caggaaaaca 4680
aaagcaaatt tctcagtgaa cacaatagta gagcagctga ggcatgagaa tgctaccagg 4740
aaaaaggtta aacacaacct tgatgcaata ttccagggtc ttggtgactc agaaacacca 4800
ggttttatag ttgatctgct atcctcatct aaagacccca aagttataga atattgtgct 4860
gaacagggat ggataggtaa agcaaactca accatagaga gggattttaa ttatgtgcat 4920
tacatgttaa attgcttagg tagtctaata attatcttag ggactgtata tgcactatac 4980
aagctgatgt gtatgactca aggaccttac actggcttac caaaccccca aaccaaaaga 5040
ccagagctca ggaaagccac actacagggc cctgagcatg aattcgtcag ggctttaatt 5100
aaaagaaact gccatgtgat aaccacctca aaaggggagt tcaacatgct tggaatccat 5160
gataactgtg cggtggtgcc aacacacgct gaatgtggtg actctgtcac aattgacggc 5220
agggaagtca gggttcttaa acaatgcatt ctcactgaca caaatgacac agacactgaa 5280
ataactctcc tctggttaga tcagaatgaa aaatttaggg acattagaag gttcatccca 5340
gaacaccaac gcgaatggtc aaatatgcat cttgccacaa atgtaactaa attccccatg 5400
ctagatgtgg aggttggcac tgtaatacca tatggagagg tcaacctcag tggtaaccca 5460
acatgtcggc ttctcaagta caactatcct acaaagccag gacaatgtgg tggtgtcatt 5520
gcaaacacag gaaacatagt agcaattcat gttggcggaa atggacgtgt ggggtatgga 5580
gcagcattgc tacgtaagta cttcgcacag tctcaaggtg agatcactgc caaacatgat 5640
gttagagaaa aaggtttgcc acaaattaac acacctaata aaacaaaatt acaacccagt 5700
gtattttatg atgtttttcc aggggtgaag gaaccggcag ccttaagcaa tggagaccca 5760
cggcttgagg ttgatctcag tacatctgtg ttaagtaagt acaaaggtaa cacacaagtg 5820
gaatggaatg ataatatcca gattgcagtt gaccactact cagctcaact ttacatgtta 5880
gacatcaatc ctcaaccatt aaccatggaa caggcagtct atggcataga gcatctggaa 5940
ccactagacc tcaccaccag tgcaggattc ccctatgtaa ctatgggtat aaagaaaaag 6000
gatatagtca acaaagtgac aaaggatgta accaaacttc aggaaatgat tgacaaatat 6060
ggaatagact tgccttatgt cacctatcta aaagatgaat tgagagctcc tgagaaaatc 6120
aagaaaggga aaacgagagc aatagaggca gctagcataa atgacacaac ccacttccgc 6180
atggtgttcg gtaatctctt ttctgtattc catgctaacc caggtgtact tacaggctct 6240
gcagtaggct gtaaccctga tgtgttctgg tctcaaatgt atgcatgtat ggatggtgag 6300
ttgcttgctt ttgattacac aaactatgat ggtagtttgc acccaatctg gttcaaagca 6360
ctaggtaaag tcttagacaa tttgggattc ccaggtcact tagtaaatag attgtgcaat 6420
acaacacaca tctttaaaaa cttgatttat actgtggaag gaggtatgcc ctctggtatc 6480
tgtggcacaa gtattttcaa taccatgatc aataatataa tcattagagt gttggttctt 6540
gaaacataca agaatataga tctggacaag ctaaaaatta tagcatatgg tgatgatgta 6600
gtagtgtcat acccttttga attggatcca atggaaattg ccaataaggc agtgaggtat 6660
gggttaacca tcactccacc agacaagggc agtacatttc ataagattga ttggacaaat 6720
gtcacctttc tcaaaaggca tttcaaacca gacaccaaat acaaatttct gatacatcca 6780
gtatacaaga tggaggacat ctatgaatca attagatgga caaaggaccc aaagaacaca 6840
caagaccatg ttcactcatt gtgtctactt gcatggcaca acggagagga ggtctatgaa 6900
aagtttaggg agaaaatcag atctacaagt gttggtaagg ttctctacac ccctccttac 6960
tcattgttgt acaggcaatg gatagatcaa ttcatataaa caaataatat aatacaatgt 7020
ttgagtagaa cttagtatta taaaaaaaaa aaaaaaaaaa aaaaaaaaaa 7070
<210> 91
<211> 6945
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 91
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaagggttc 2880
agacaacaat gaatatggaa ttgctcccac caatgacatg ggtttgttat gcttcaggac 2940
tttggacaat agtggtggaa atgatgtgaa aatatacgtc aaacccaaac acataacggc 3000
atgggtacca agaccaccaa gggcaacaca gtacacccac aagtacagta caaactacca 3060
ttacaaacct aactctagtg gacctgatga acacgtgctt aaagacagac actttatcaa 3120
aaccagaccc ctcatcagct cagcgggacc gagcgacatg tttgtgcaca caagagatgc 3180
aatttataaa tgtgcacatc taaccaatcc aactgatgaa accatacttc tggcattgac 3240
tgcagatcta caggtgggtg actgtggagg caagttacta tgcaagcatg gtgtgattgg 3300
tatgatcact gcaggtggtg ataaccatgt tgctttcact gacctacgcc catactcaag 3360
cttatcagaa caccaagggg ttatttcaga ttacttcacc cagttgggta atgcatttgg 3420
tgagggcttc acaaccaaca ttcaagacca cttttcacaa atcaccaagt caatttctga 3480
caaatttaca tcaaaggcta ttaaatggtt ggtgcgcatc ataagcgccc ttacaattat 3540
gattagaaac aactcagact tgcctaccat acttgctact ctgtcattgt tggggtgtag 3600
tagctcacca tggtctttcc tcaaggacaa aatctgcagc tggcttcaaa tccagcgtcc 3660
cgcaagcaaa cagagtgatt catggttgcg caaattcaca gaatgttgca atgcagcaaa 3720
aggacttgaa tggatcagta tcaagattgg caagtttatt gattggctga aagggaaact 3780
agtccccgct gtccagagga aaagagacac cctagataga tgcaagaaaa tatctctctt 3840
agaagaacaa gtgaatggat tcagttctgc tagctcagaa gcacaacaac aacttattgt 3900
agaagtggat actctaaaga agggtttaga tgagctggca ccattgtatg ctagtgaaaa 3960
caaaagggtg actaagattc aaaaagatct caaacaacta tcagcttatc taaagaacca 4020
taggcatgaa ccagtttgct tattgttaca tggcaaccca ggatgtggaa aatcactagt 4080
tacaaccata atcgctagag gactcaccca ggaggcacag gtatactcac taccacctga 4140
tcccaaatat ttcgatggtt atgaccaaca gcaggttgtc atattggatg atcttggaca 4200
aaatcctgat ggtaaagatt taagcacatt ctgtcagatg gtatcaacaa cagatttcat 4260
agtacctatg gcatcactag aggataaggg taagtctttc accagccaat atgtgcttgc 4320
cagcactaac ctggacactc tgtcaccacc aacagtcaca atacctgagg ctataaaacg 4380
gcgattcttt ctggatgccg atctcatcac aacatctaag ttcagaaata ccacaggact 4440
gctagatgta gcaaaggcac tacaaccatg cacaggttgt cccaaaccag ctcactataa 4500
aacgtgctgt cctctgttgt gtggcaaggc agttgtagtt caggacagga aaacaaaagc 4560
aaatttctca gtgaacacaa tagtagagca gctgaggcat gagaatgcta ccaggaaaaa 4620
ggttaaacac aaccttgatg caatattcca gggtcttggt gactcagaaa caccaggttt 4680
tatagttgat ctgctatcct catctaaaga ccccaaagtt atagaatatt gtgctgaaca 4740
gggatggata ggtaaagcaa actcaaccat agagagggat tttaattatg tgcattacat 4800
gttaaattgc ttaggtagtc taataattat cttagggact gtatatgcac tatacaagct 4860
gatgtgtatg actcaaggac cttacactgg cttaccaaac ccccaaacca aaagaccaga 4920
gctcaggaaa gccacactac agggccctga gcatgaattc gtcagggctt taattaaaag 4980
aaactgccat gtgataacca cctcaaaagg ggagttcaac atgcttggaa tccatgataa 5040
ctgtgcggtg gtgccaacac acgctgaatg tggtgactct gtcacaattg acggcaggga 5100
agtcagggtt cttaaacaat gcattctcac tgacacaaat gacacagaca ctgaaataac 5160
tctcctctgg ttagatcaga atgaaaaatt tagggacatt agaaggttca tcccagaaca 5220
ccaacgcgaa tggtcaaata tgcatcttgc cacaaatgta actaaattcc ccatgctaga 5280
tgtggaggtt ggcactgtaa taccatatgg agaggtcaac ctcagtggta acccaacatg 5340
tcggcttctc aagtacaact atcctacaaa gccaggacaa tgtggtggtg tcattgcaaa 5400
cacaggaaac atagtagcaa ttcatgttgg cggaaatgga cgtgtggggt atggagcagc 5460
attgctacgt aagtacttcg cacagtctca aggtgagatc actgccaaac atgatgttag 5520
agaaaaaggt ttgccacaaa ttaacacacc taataaaaca aaattacaac ccagtgtatt 5580
ttatgatgtt tttccagggg tgaaggaacc ggcagcctta agcaatggag acccacggct 5640
tgaggttgat ctcagtacat ctgtgttaag taagtacaaa ggtaacacac aagtggaatg 5700
gaatgataat atccagattg cagttgacca ctactcagct caactttaca tgttagacat 5760
caatcctcaa ccattaacca tggaacaggc agtctatggc atagagcatc tggaaccact 5820
agacctcacc accagtgcag gattccccta tgtaactatg ggtataaaga aaaaggatat 5880
agtcaacaaa gtgacaaagg atgtaaccaa acttcaggaa atgattgaca aatatggaat 5940
agacttgcct tatgtcacct atctaaaaga tgaattgaga gctcctgaga aaatcaagaa 6000
agggaaaacg agagcaatag aggcagctag cataaatgac acaacccact tccgcatggt 6060
gttcggtaat ctcttttctg tattccatgc taacccaggt gtacttacag gctctgcagt 6120
aggctgtaac cctgatgtgt tctggtctca aatgtatgca tgtatggatg gtgagttgct 6180
tgcttttgat tacacaaact atgatggtag tttgcaccca atctggttca aagcactagg 6240
taaagtctta gacaatttgg gattcccagg tcacttagta aatagattgt gcaatacaac 6300
acacatcttt aaaaacttga tttatactgt ggaaggaggt atgccctctg gtatctgtgg 6360
cacaagtatt ttcaatacca tgatcaataa tataatcatt agagtgttgg ttcttgaaac 6420
atacaagaat atagatctgg acaagctaaa aattatagca tatggtgatg atgtagtagt 6480
gtcataccct tttgaattgg atccaatgga aattgccaat aaggcagtga ggtatgggtt 6540
aaccatcact ccaccagaca agggcagtac atttcataag attgattgga caaatgtcac 6600
ctttctcaaa aggcatttca aaccagacac caaatacaaa tttctgatac atccagtata 6660
caagatggag gacatctatg aatcaattag atggacaaag gacccaaaga acacacaaga 6720
ccatgttcac tcattgtgtc tacttgcatg gcacaacgga gaggaggtct atgaaaagtt 6780
tagggagaaa atcagatcta caagtgttgg taaggttctc tacacccctc cttactcatt 6840
gttgtacagg caatggatag atcaattcat ataaacaaat aatataatac aatgtttgag 6900
tagaacttag tattataaaa aaaaaaaaaa aaaaaaaaaa aaaaa 6945
<210> 92
<211> 7088
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 92
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaagggttc 2880
agacaacaat gaatatggaa ttgctcccac caatgacatg ggtttgttat gcttcaggac 2940
tttggacaat agtggtggaa atgatgtgaa aatatacgtc aaacccaaac acataacggc 3000
atgggtacca agaccaccaa gggcaacaca gtacacccac aagtacagta caaactacca 3060
ttacaaacct aactctagtg gacctgatga acacgtgctt aaagacagac actttatcaa 3120
aaccagaccc ctcatcagct cagcgggacc gagcgacatg tttgtgcaca caagagatgc 3180
aatttataaa tgtgcacatc taaccaatcc aactgatgaa accatacttc tggcattgac 3240
tgcagatcta caggtggata gtaccaatgt tccaggcccc gatgtgattc cgtgttgtga 3300
ttgcactgct ggttgctact actctagaag caaagacaga tacttcccag tggagtgtgt 3360
tagtcatgac tggtatgaga tacaagaatc tggctactat cccaaacata tacaatataa 3420
tctactcatt ggggaaggac actgtgaacc aggtgactgt ggaggcaagt tactatgcaa 3480
gcatggtgtg attggtatga tcactgcagg tggtgataac catgttgctt tcactgacct 3540
acgcccatac tcaagcttat cagaacacca aggggttatt tcagattact tcacccagtt 3600
gggtaatgca tttggtgagg gcttcacaac caacattcaa gaccactttt cacaaatcac 3660
caagtcaatt tctgacaaat ttacatcaaa ggctattaaa tggttggtgc gcatcataag 3720
cgcccttaca attatgatta gaaacaactc agacttgcct accatacttg ctactctgtc 3780
attgttgggg tgtagtagct caccatggtc tttcctcaag gacaaaatct gcagctggct 3840
tcaaatccag cgtcccgcaa gcaaacagag tgattcatgg ttgcgcaaat tcacagaatg 3900
ttgcaatgca gcaaaaggac ttgaatggat cagtatcaag attggcaagt ttattgattg 3960
gctgaaaggg aaactagtcc ccgctgtcca gaggaaaaga gacaccctag atagatgcaa 4020
gaaaatatct ctcttagaag aacaagtgaa tggattcagt tctgctagct cagaagcaca 4080
acaacaactt attgtagaag tggatactct aaagaagggt ttagatgagc tggcaccatt 4140
gtatgctagt gaaaacaaaa gggtgactaa gattcaaaaa gatctcaaac aactatcagc 4200
ttatctaaag aaccataggc atgaaccagt ttgcttattg ttacatggca acccaggatg 4260
tggaaaatca ctagttacaa ccataatcgc tagaggactc acccaggagg cacaggtata 4320
ctcactacca cctgatccca aatatttcga tggttatgac caacagcagg ttgtcatatt 4380
ggatgatctt ggacaaaatc ctgatggtaa agatttaagc acattctgtc agatggtatc 4440
aacaacagat ttcatagtac ctatggcatc actagaggat aagggtaagt ctttcaccag 4500
ccaatatgtg cttgccagca ctaacctgga cactctgtca ccaccaacag tcacaatacc 4560
tgaggctata aaacggcgat tctttctgga tgccgatctc atcacaacat ctaagttcag 4620
aaataccaca ggactgctag atgtagcaaa ggcactacaa ccatgcacag gttgtcccaa 4680
accagctcac tataaaacgt gctgtctttc tcagtgaaca caatagtaga gcagctgagg 4740
catgagaatg ctaccaggaa aaaggttaaa cacaaccttg atgcaatatt ccagggtctt 4800
ggtgactcag aaacaccagg ttttatagtt gatctgctat cctcatctaa agaccccaaa 4860
gttatagaat attgtgctga acagggatgg ataggtaaag caaactcaac catagagagg 4920
gattttaatt atgtgcatta catgttaaat tgcttaggta gtctaataat tatcttaggg 4980
actgtatatg cactatacaa gctgatgtgt atgactcaag gaccttacac tggcttacca 5040
aacccccaaa ccaaaagacc agagctcagg aaagccacac tacagggccc tgagcatgaa 5100
ttcgtcaggg ctttaattaa aagaaactgc catgtgataa ccacctcaaa aggggagttc 5160
aacatgcttg gaatccatga taactgtgcg gtggtgccaa cacacgctga atgtggtgac 5220
tctgtcacaa ttgacggcag ggaagtcagg gttcttaaac aatgcattct cactgacaca 5280
aatgacacag acactgaaat aactctcctc tggttagatc agaatgaaaa atttagggac 5340
attagaaggt tcatcccaga acaccaacgc gaatggtcaa atatgcatct tgccacaaat 5400
gtaactaaat tccccatgct agatgtggag gttggcactg taataccata tggagaggtc 5460
aacctcagtg gtaacccaac atgtcggctt ctcaagtaca actatcctac aaagccagga 5520
caatgtggtg gtgtcattgc aaacacagga aacatagtag caattcatgt tggcggaaat 5580
ggacgtgtgg ggtatggagc agcattgcta cgtaagtact tcgcacagtc tcaaggtgag 5640
atcactgcca aacatgatgt tagagaaaaa ggtttgccac aaattaacac acctaataaa 5700
acaaaattac aacccagtgt attttatgat gtttttccag gggtgaagga accggcagcc 5760
ttaagcaatg gagacccacg gcttgaggtt gatctcagta catctgtgtt aagtaagtac 5820
aaaggtaaca cacaagtgga atggaatgat aatatccaga ttgcagttga ccactactca 5880
gctcaacttt acatgttaga catcaatcct caaccattaa ccatggaaca ggcagtctat 5940
ggcatagagc atctggaacc actagacctc accaccagtg caggattccc ctatgtaact 6000
atgggtataa agaaaaagga tatagtcaac aaagtgacaa aggatgtaac caaacttcag 6060
gaaatgattg acaaatatgg aatagacttg ccttatgtca cctatctaaa agatgaattg 6120
agagctcctg agaaaatcaa gaaagggaaa acgagagcaa tagaggcagc tagcataaat 6180
gacacaaccc acttccgcat ggtgttcggt aatctctttt ctgtattcca tgctaaccca 6240
ggtgtactta caggctctgc agtaggctgt aaccctgatg tgttctggtc tcaaatgtat 6300
gcatgtatgg atggtgagtt gcttgctttt gattacacaa actatgatgg tagtttgcac 6360
ccaatctggt tcaaagcact aggtaaagtc ttagacaatt tgggattccc aggtcactta 6420
gtaaatagat tgtgcaatac aacacacatc tttaaaaact tgatttatac tgtggaagga 6480
ggtatgccct ctggtatctg tggcacaagt attttcaata ccatgatcaa taatataatc 6540
attagagtgt tggttcttga aacatacaag aatatagatc tggacaagct aaaaattata 6600
gcatatggtg atgatgtagt agtgtcatac ccttttgaat tggatccaat ggaaattgcc 6660
aataaggcag tgaggtatgg gttaaccatc actccaccag acaagggcag tacatttcat 6720
aagattgatt ggacaaatgt cacctttctc aaaaggcatt tcaaaccaga caccaaatac 6780
aaatttctga tacatccagt atacaagatg gaggacatct atgaatcaat tagatggaca 6840
aaggacccaa agaacacaca agaccatgtt cactcattgt gtctacttgc atggcacaac 6900
ggagaggagg tctatgaaaa gtttagggag aaaatcagat ctacaagtgt tggtaaggtt 6960
ctctacaccc ctccttactc attgttgtac aggcaatgga tagatcaatt catataaaca 7020
aataatataa tacaatgttt gagtagaact tagtattata aaaaaaaaaa aaaaaaaaaa 7080
aaaaaaaa 7088
<210> 93
<211> 8872
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 93
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagttg gcatcaacac aagaaacatg acaatgtcca tgagcatgat 420
cttggtagga gtgatcatga tgtttttgtc tctaggagtt ggggcggatc aaggatgcgc 480
catcaacttt ggcaagagag agctcaagtg cggagatggt atcttcatat ttagagactc 540
tgatgactgg ctgaacaagt actcatacta tccagaagat cctgtgaagc tggcatcaat 600
agtgaaagcc tcttttgaag aagggaagtg tggcctaaat tcagttgact cccttgagca 660
tgagatgtgg agaagcaggg cagatgagat caatgccatt cttgaggaaa acgaggtgga 720
catttctgtt gtcgtgcagg atccaaagaa tgtttaccag agaggaactc atccattttc 780
cagaattcgg gatggtctgc agtatggttg gaagacttgg ggtaagaacc ttgtgttctc 840
cccagggagg aagaatggaa gcttcatcat agatggaaag tccaggaaag aatgcccgtt 900
ttcaaaccgg gtctggaatt ctttccagat agaggagttt gggacgggag tgttcaccac 960
acgcgtgtac atggacgcag tctttgaata caccatagac tgcgatggat ctatcttggg 1020
tgcagcggtg aacggaaaaa agagtgccca tggctctcca acattttgga tgggaagtca 1080
tgaagtaaat gggacatgga tgatccacac cttggaggca ttagattaca aggagtgtga 1140
gtggccactg acacatacga ttggaacatc agttgaagag agtgaaatgt tcatgccgag 1200
atcaatcgga ggcccagtta gctctcacaa tcatatccct ggatacaagg ttcagacgaa 1260
cggaccttgg atgcaggtac cactagaggt gaagagagaa gcttgcccag ggactagcgt 1320
gatcattgat ggcaactgtg atggacgggg aaaatcaacc agatccacca cggatagcgg 1380
gaaaattatt cctgaatggt gttgccgctc ctgcacaatg ccgcctgtga gcttccatgg 1440
tagtgatggg tgttggtatc ccatggaaat taggccaagg aaaacgcatg aaagccatct 1500
ggtgcgctcc tgggttacag ctggagaaat acatgctgtc ccttttggtt tggtgagcat 1560
gatgatagca atggaagtgg tcctaaggaa aagacaggga ccaaagcaaa tgttggttgg 1620
aggagtggtg ctcttgggag caatgctggt cgggcaagta actctccttg atttgctgaa 1680
actcacagtg gctgtgggat tgcatttcca tgagatgaac aatggaggag acgccatgta 1740
tatggcgttg attgctgcct tttcaatcag accagggctg ctcatcggct ttgggctcag 1800
gaccctatgg agccctcggg aacgccttgt gctgacccta ggagcagcca tggtggagat 1860
tgccttgggt ggcatgatgg gcggcctgtg gaagtatcta aatgcagttt ctctctgcat 1920
cctgacaata aatgctgttg cttctaggaa agcatcaaat accatcttgc ccctcatggc 1980
tctgttgaca cctgtcacta tggctgaggt gagacttgcc acaatgctct tttgtaccgt 2040
ggttatcata ggggtccttc accagaactc caaggacacc tccatgcaga agactatacc 2100
tctggtggcc ctcacactca catcttacct gggcttgaca caaccttttt tgggcctgtg 2160
tgcatttctg gcaacccgca tatttgggcg aaggagtatc ccagtgaatg aggcactcgc 2220
agcagctggt ctagtgggag tgctggcagg actggctttt caggagatgg agaacttcct 2280
tggtccgatt gcagttggag gaatcctgat gatgctggtt agcgtggctg ggagggtgga 2340
tgggctagag ctcaagaagc ttggtgaagt ttcatgggaa gaggaggcgg agatcagcgg 2400
aagttccgcc cgctatgatg tggcactcag tgaacaaggg gagttcaagc tgctttctga 2460
agagaaagtg ccatgggacc aggttgtgat gacctcgctg gccttggttg gggctgccat 2520
tcatccattt gctcttctgc tggtccttgc tgggtggctg tttcatgtca ggggagctag 2580
gagaagtggg gatgtcttgt gggatattcc cactcctaag atcattgagg aatgtgaaca 2640
tctggaggat gggatttatg gcatattcca gtcaaccttc ttgggggcct cccagcgagg 2700
agtgggagtg gcacagggag gggtgttcca cacaatgtgg catgtcacaa gaggagcttt 2760
ccttgtcagg aatggcaaga agttgattcc atcttgggct tcagtaaagg aagaccttgt 2820
cgcctatggt ggctcatgga agttggaagg cagatgggat ggagaggaag aggtccaatt 2880
gatcgctgct gttccaggaa agaacgtggt caacgtccag acaaaaccga gcttgttcaa 2940
agtgaggaat gggggagaaa tcggggctgt cgctcttgac tatccgagtg gcacttcagg 3000
atctcctatt gttaacagga acggagaggt gattgggctg tacggcaatg gcatccttgt 3060
cggtgacaac tccttcgtgt ccgccatatc ccagactgag gtgaaggaag aaggaaagga 3120
ggagctccaa gagatcccga caatgctaaa gaaaggaatg acaactatcc ttgattttca 3180
tcctggagct gggaagacaa gacgttttct cccacagatc ttggccgagt gcgcacggag 3240
acgcttgcgc actcttgtgt tggcccccac cagggttgtt ctttctgaaa tgaaggaggc 3300
ttttcacggc ctggacgtga aattccacac acaggctttt tccgctcacg gcagcgggag 3360
agaagtcatt gatgccatgt gccatgccac cctaacttac aggatgttgg aaccaactag 3420
ggttgttaac tgggaagtga tcatcatgga tgaagcccat tttttggatc cagctagcat 3480
agccgccaga ggttgggcag cgcacagagc tagggcaaat gaaagtgcaa caatcttgat 3540
gacagccaca ccgcctggga ctagtgatga atttccacat tcaaatggtg aaatagaaga 3600
tgttcaaacg gacataccca gtgagccctg gaacacaggg catgactgga tcctggctga 3660
caaaaggccc acggcatggt tccttccatc catcagagct gcaaatgtca tggctgcctc 3720
tttgcgtaag gctggaaaga gtgtggtggt cctgaacagg aaaacctttg agagagaata 3780
ccccacgata aagcagaaga aacctgactt tatattggcc actgacatag ctgaaatggg 3840
agccaacctt tgcgtggagc gagtgctgga ttgcaggacg gcttttaagc ctgtgcttgt 3900
ggatgaaggg aggaaggtgg caataaaagg gccacttcgc atctccgcat cctctgctgc 3960
tcaaaggagg gggcgcattg ggagaaatcc caacagagat ggagactcat actactattc 4020
tgagcccaca agtgaagata atgcccacca cgtctgctgg ttggaggcct caatgctctt 4080
ggacaacatg gaggtgaggg gtggaatggt cgccccactc tatggcgttg aaggaactaa 4140
aacaccagtt tcccctggtg aaatgagact gagggatgac cagaggaaag tcttcagaga 4200
actagtgagg aattgtgacc tgcccgtttg gctttcgtgg caagtggcca aggctggttt 4260
gaagacgaat gatcgtaagt ggtgttttga aggccctgag gaacatgaga tcttgaatga 4320
cagcggtgaa acagtgaagt gcagggctcc tggaggagca aagaagcctc tgcgcccaag 4380
gtggtgtgat gaaagggtgt catctgacca gagtgcgctg tctgaattta ttaagtttgc 4440
tgaaggtagg aggggagctg cggaagtgct agttgtgctg agtgaactcc ctgatttcct 4500
ggctaaaaaa ggtggagagg caatggatac catcagtgtg tttctccact ctgaggaagg 4560
ctctagggct taccgcaatg cactatcaat gatgcctgag gcaatgacaa tagtcatgct 4620
gtttatactg gctggactac tgacatcggg aatggtcatc tttttcatgt ctcccaaagg 4680
catcagtaga atgtctatgg cgatgggcac aatggccggc tgtggatatc tcatgttcct 4740
tggaggcgtc aaacccactc acatctccta tatcatgctc atattctttg tcctgatggt 4800
ggttgtgatc cccgagccag ggcaacaaag gtccatccaa gacaaccaag tggcatacct 4860
cattattggc atcctgacgc tggtttcagt ggtggcagcc aacgagctag gcatgctgga 4920
gaaaaccaaa gaggacctct ttgggaagaa gaacttaatt ccatctagtg cttcaccctg 4980
gagttggccg gatcttgacc tgaagccagg agctgcctgg acagtgtacg ttggcattgt 5040
tacaatgctc tctccaatgt tgcaccactg gatcaaagtc gaatatggca acctgtctct 5100
gtctggaata gcccagtcag cctcagtcct ttctttcatg gacaagggga taccattcat 5160
gaagatgaat atctcggtca taatactgct ggtcagtggc tggaattcaa taacagtgat 5220
gcctctgctc tgtggcatag ggtgcgccat gctccactgg tctctcattt tacctggaat 5280
caaagcgcag cagtcaaagc ttgcacagag aagggtgttc catggcgttg ccaagaaccc 5340
tgtggttgat gggaatccaa cagttgacat tgaggaagct cctgaaatgc ctgcccttta 5400
tgagaagaaa ctggctctat atctccttct tgctctcagc ctagcttctg ttgccatgtg 5460
cagaacgccc ttttcattgg ctgaaggcat tgtcctagca tcagctgcct tagggccgct 5520
catagaggga aacaccagcc ttctttggaa tggacccatg gctgtctcca tgacaggagt 5580
catgcggggg aattactatg cttttgtggg agtcatgtac aatctatgga agatgaaaac 5640
tggacgccgg gggagtgcga atggaaaaac tttgggtgaa gtctggaaga gggaactgaa 5700
tctgttggac aagcaacagt ttgagttgta taaaaggacc gacattgtgg aggtggatcg 5760
tgatacggca cgcaggcatt tggccgaagg gaaggtggac accggggtgg cggtctccag 5820
ggggaccgca aagttaaggt ggttccatga gcgtggctat gtcaagctgg aaggtagggt 5880
gattgacctg gggtgtggcc gcggaggctg gtgttactac gctgctgcgc aaaaggaagt 5940
gagtggggtc aaaggattta ctcttggaag agacggccat gagaaaccca tgaatgtgca 6000
aagtctggga tggaacatca tcaccttcaa ggacaaaact gatatccacc gcctagaacc 6060
agtgaaatgt gacacccttt tgtgtgacat tggagagtca tcatcgtcat cggtcacaga 6120
gggggaaagg accgtgagag ttcttgatac tgtagaaaaa tggctggctt gtggggttga 6180
caacttctgt gtgaaggtgt tagctccata catgccagat gttcttgaga aactggaatt 6240
gctccaaagg aggtttggcg gaacagtgat caggaaccct ctctccagga attccactca 6300
tgaaatgtac tacgtgtctg gagcccgcag caatgtcaca tttactgtga accaaacatc 6360
ccgcctcctg atgaggagaa tgaggcgtcc aactggaaaa gtgaccctgg aggctgacgt 6420
catcctccca attgggacac gcagtgttga gacagacaag ggacccctgg acaaagaggc 6480
catagaagaa agggttgaga ggataaaatc tgagtacatg acctcttggt tttatgacaa 6540
tgacaacccc tacaggacct ggcactactg tggctcctat gtcacaaaaa cctcaggaag 6600
tgcggcgagc atggtaaatg gtgttattaa aattctgaca tacccatggg acaggataga 6660
ggaggtcaca agaatggcaa tgactgacac aacccctttt ggacagcaaa gagtgtttaa 6720
agaaaaagtt gacaccagag caaaggatcc accagcggga actaggaaga tcatgaaagt 6780
tgtcaacagg tggctgttcc gccacctggc cagagaaaag aaccccagac tgtgcacaaa 6840
ggaagaattt attgcaaaag tccgaagtca tgcagccatt ggagcttacc tggaagaaca 6900
agaacagtgg aagactgcca atgaggctgt ccaagaccca aagttctggg aactggtgga 6960
tgaagaaagg aagctgcacc aacaaggcag gtgtcggact tgtgtgtaca acatgatggg 7020
gaaaagagag aagaagctgt cagagtttgg gaaagcaaag ggaagccgtg ccatatggta 7080
tatgtggctg ggagcgcggt atcttgagtt tgaggccctg ggattcctga atgaggacca 7140
ttgggcttcc agggaaaact caggaggagg agtggaaggc attggcttac aatacctagg 7200
atatgtgatc agagacctgg ctgcaatgga tggtggtgga ttctacgcgg atgacaccgc 7260
tggatgggac acgcgcatca cagaggcaga ccttgatgat gaacaggaga tcttgaacta 7320
catgagccca catcacaaaa aactggcaca agcagtgatg gaaatgacat acaagaacaa 7380
agtggtgaaa gtgttgagac cagccccagg agggaaagcc tacatggatg tcataagtcg 7440
acgagaccag agaggatccg ggcaggtagt gacttatgct ctgaacacca tcaccaactt 7500
gaaagtccaa ttgatcagaa tggcagaagc agagatggtg atacatcacc aacatgttca 7560
agattgtgat gaatcagttc tgaccaggct ggaggcatgg ctcactgagc acggatgtaa 7620
cagactgaag aggatggcgg tgagtggaga cgactgtgtg gtccggccca tcgatgacag 7680
gttcggcctg gccctgtccc atctcaacgc catgtccaag gttagaaagg acatatctga 7740
atggcagcca tcaaaagggt ggaatgattg ggagaatgtg cccttctgtt cccaccactt 7800
ccatgaacta cagctgaagg atggcaggag gattgtggtg ccttgccgag aacaggacga 7860
gctcattggg agaggaaggg tgtctccagg aaacggctgg atgatcaagg aaacagcttg 7920
cctcagcaaa gcctatgcca acatgtggtc actgatgtat tttcacaaaa gggacatgag 7980
gctactgtca ttggctgttt cctcagctgt tcccacctca tgggttccac aaggacgcac 8040
aacatggtcg attcatggga aaggggagtg gatgaccacg gaagacatgc ttgaggtgtg 8100
gaacagagta tggataacca acaacccaca catgcaggac aagacaatgg tgaaagaatg 8160
gagagatgtc ccttatctaa ccaagagaca agacaagctg tgcggatcac tgattggaat 8220
gaccaatagg gccacctggg cctcccacat ccatttggtc atccatcgta tccgaacgct 8280
gattggacag gagaaatata ctgactacct aacagtcatg gacagatatt ctgtggatgc 8340
tgacctgcaa ccgggtgagc ttatctgaaa caccatctaa taggaataac cgggatacaa 8400
accacgggtg gagaaccgga ctccccacaa cttgaaaccg ggatataaac cacggctgga 8460
gaaccggact ccgcacttaa aatgaaacag aaaccgggat aaaaactacg gatggagaac 8520
cggactccac acattgagac agaagaagtt gtcagcccag aactccacac gagttttgcc 8580
actgctaagc tgtgaggcag tgcaggctgg gacagccgac ctccaggttg cgaaaaacct 8640
ggtttctggg acctcccacc ccagagtaaa aagaacggag cctccgctac caccctccca 8700
cgtggtggta gaaagacggg gtctagaggt tagaggagac cctccaggga acaaatagtg 8760
ggaccatatt gacgccaggg aaagaccgga gtggttctct gcttttcctc caggggtctg 8820
tgagcacagt ttgctcaaga ataagcagac ctttggatga caaacacaaa ac 8872
<210> 94
<211> 8419
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 94
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttaaaga gtgcccatgg 600
ctctccaaca ttttggatgg gaagtcatga agtaaatggg acatggatga tccacacctt 660
ggaggcatta gattacaagg agtgtgagtg gccactgaca catacgattg gaacatcagt 720
tgaagagagt gaaatgttca tgccgagatc aatcggaggc ccagttagct ctcacaatca 780
tatccctgga tacaaggttc agacgaacgg accttggatg caggtaccac tagaggtgaa 840
gagagaagct tgcccaggga ctagcgtgat cattgatggc aactgtgatg gacggggaaa 900
atcaaccaga tccaccacgg atagcgggaa aattattcct gaatggtgtt gccgctcctg 960
cacaatgccg cctgtgagct tccatggtag tgatgggtgt tggtatccca tggaaattag 1020
gccaaggaaa acgcatgaaa gccatctggt gcgctcctgg gttacagctg gagaaataca 1080
tgctgtccct tttggtttgg tgagcatgat gatagcaatg gaagtggtcc taaggaaaag 1140
acagggacca aagcaaatgt tggttggagg agtggtgctc ttgggagcaa tgctggtcgg 1200
gcaagtaact ctccttgatt tgctgaaact cacagtggct gtgggattgc atttccatga 1260
gatgaacaat ggaggagacg ccatgtatat ggcgttgatt gctgcctttt caatcagacc 1320
agggctgctc atcggctttg ggctcaggac cctatggagc cctcgggaac gccttgtgct 1380
gaccctagga gcagccatgg tggagattgc cttgggtggc atgatgggcg gcctgtggaa 1440
gtatctaaat gcagtttctc tctgcatcct gacaataaat gctgttgctt ctaggaaagc 1500
atcaaatacc atcttgcccc tcatggctct gttgacacct gtcactatgg ctgaggtgag 1560
acttgccaca atgctctttt gtaccgtggt tatcataggg gtccttcacc agaactccaa 1620
ggacacctcc atgcagaaga ctatacctct ggtggccctc acactcacat cttacctggg 1680
cttgacacaa ccttttttgg gcctgtgtgc atttctggca acccgcatat ttgggcgaag 1740
gagtatccca gtgaatgagg cactcgcagc agctggtcta gtgggagtgc tggcaggact 1800
ggcttttcag gagatggaga acttccttgg tccgattgca gttggaggaa tcctgatgat 1860
gctggttagc gtggctggga gggtggatgg gctagagctc aagaagcttg gtgaagtttc 1920
atgggaagag gaggcggaga tcagcggaag ttccgcccgc tatgatgtgg cactcagtga 1980
acaaggggag ttcaagctgc tttctgaaga gaaagtgcca tgggaccagg ttgtgatgac 2040
ctcgctggcc ttggttgggg ctgccattca tccatttgct cttctgctgg tccttgctgg 2100
gtggctgttt catgtcaggg gagctaggag aagtggggat gtcttgtggg atattcccac 2160
tcctaagatc attgaggaat gtgaacatct ggaggatggg atttatggca tattccagtc 2220
aaccttcttg ggggcctccc agcgaggagt gggagtggca cagggagggg tgttccacac 2280
aatgtggcat gtcacaagag gagctttcct tgtcaggaat ggcaagaagt tgattccatc 2340
ttgggcttca gtaaaggaag accttgtcgc ctatggtggc tcatggaagt tggaaggcag 2400
atgggatgga gaggaagagg tccaattgat cgctgctgtt ccaggaaaga acgtggtcaa 2460
cgtccagaca aaaccgagct tgttcaaagt gaggaatggg ggagaaatcg gggctgtcgc 2520
tcttgactat ccgagtggca cttcaggatc tcctattgtt aacaggaacg gagaggtgat 2580
tgggctgtac ggcaatggca tccttgtcgg tgacaactcc ttcgtgtccg ccatatccca 2640
gactgaggtg aaggaagaag gaaaggagga gctccaagag atcccgacaa tgctaaagaa 2700
aggaatgaca actatccttg attttcatcc tggagctggg aagacaagac gttttctccc 2760
acagatcttg gccgagtgcg cacggagacg cttgcgcact cttgtgttgg cccccaccag 2820
ggttgttctt tctgaaatga aggaggcttt tcacggcctg gacgtgaaat tccacacaca 2880
ggctttttcc gctcacggca gcgggagaga agtcattgat gccatgtgcc atgccaccct 2940
aacttacagg atgttggaac caactagggt tgttaactgg gaagtgatca tcatggatga 3000
agcccatttt ttggatccag ctagcatagc cgccagaggt tgggcagcgc acagagctag 3060
ggcaaatgaa agtgcaacaa tcttgatgac agccacaccg cctgggacta gtgatgaatt 3120
tccacattca aatggtgaaa tagaagatgt tcaaacggac atacccagtg agccctggaa 3180
cacagggcat gactggatcc tggctgacaa aaggcccacg gcatggttcc ttccatccat 3240
cagagctgca aatgtcatgg ctgcctcttt gcgtaaggct ggaaagagtg tggtggtcct 3300
gaacaggaaa acctttgaga gagaataccc cacgataaag cagaagaaac ctgactttat 3360
attggccact gacatagctg aaatgggagc caacctttgc gtggagcgag tgctggattg 3420
caggacggct tttaagcctg tgcttgtgga tgaagggagg aaggtggcaa taaaagggcc 3480
acttcgcatc tccgcatcct ctgctgctca aaggaggggg cgcattggga gaaatcccaa 3540
cagagatgga gactcatact actattctga gcccacaagt gaagataatg cccaccacgt 3600
ctgctggttg gaggcctcaa tgctcttgga caacatggag gtgaggggtg gaatggtcgc 3660
cccactctat ggcgttgaag gaactaaaac accagtttcc cctggtgaaa tgagactgag 3720
ggatgaccag aggaaagtct tcagagaact agtgaggaat tgtgacctgc ccgtttggct 3780
ttcgtggcaa gtggccaagg ctggtttgaa gacgaatgat cgtaagtggt gttttgaagg 3840
ccctgaggaa catgagatct tgaatgacag cggtgaaaca gtgaagtgca gggctcctgg 3900
aggagcaaag aagcctctgc gcccaaggtg gtgtgatgaa agggtgtcat ctgaccagag 3960
tgcgctgtct gaatttatta agtttgctga aggtaggagg ggagctgcgg aagtgctagt 4020
tgtgctgagt gaactccctg atttcctggc taaaaaaggt ggagaggcaa tggataccat 4080
cagtgtgttt ctccactctg aggaaggctc tagggcttac cgcaatgcac tatcaatgat 4140
gcctgaggca atgacaatag tcatgctgtt tatactggct ggactactga catcgggaat 4200
ggtcatcttt ttcatgtctc ccaaaggcat cagtagaatg tctatggcga tgggcacaat 4260
ggccggctgt ggatatctca tgttccttgg aggcgtcaaa cccactcaca tctcctatat 4320
catgctcata ttctttgtcc tgatggtggt tgtgatcccc gagccagggc aacaaaggtc 4380
catccaagac aaccaagtgg catacctcat tattggcatc ctgacgctgg tttcagtggt 4440
ggcagccaac gagctaggca tgctggagaa aaccaaagag gacctctttg ggaagaagaa 4500
cttaattcca tctagtgctt caccctggag ttggccggat cttgacctga agccaggagc 4560
tgcctggaca gtgtacgttg gcattgttac aatgctctct ccaatgttgc accactggat 4620
caaagtcgaa tatggcaacc tgtctctgtc tggaatagcc cagtcagcct cagtcctttc 4680
tttcatggac aaggggatac cattcatgaa gatgaatatc tcggtcataa tactgctggt 4740
cagtggctgg aattcaataa cagtgatgcc tctgctctgt ggcatagggt gcgccatgct 4800
ccactggtct ctcattttac ctggaatcaa agcgcagcag tcaaagcttg cacagagaag 4860
ggtgttccat ggcgttgcca agaaccctgt ggttgatggg aatccaacag ttgacattga 4920
ggaagctcct gaaatgcctg ccctttatga gaagaaactg gctctatatc tccttcttgc 4980
tctcagccta gcttctgttg ccatgtgcag aacgcccttt tcattggctg aaggcattgt 5040
cctagcatca gctgccttag ggccgctcat agagggaaac accagccttc tttggaatgg 5100
acccatggct gtctccatga caggagtcat gcgggggaat tactatgctt ttgtgggagt 5160
catgtacaat ctatggaaga tgaaaactgg acgccggggg agtgcgaatg gaaaaacttt 5220
gggtgaagtc tggaagaggg aactgaatct gttggacaag caacagtttg agttgtataa 5280
aaggaccgac attgtggagg tggatcgtga tacggcacgc aggcatttgg ccgaagggaa 5340
ggtggacacc ggggtggcgg tctccagggg gaccgcaaag ttaaggtggt tccatgagcg 5400
tggctatgtc aagctggaag gtagggtgat tgacctgggg tgtggccgcg gaggctggtg 5460
ttactacgct gctgcgcaaa aggaagtgag tggggtcaaa ggatttactc ttggaagaga 5520
cggccatgag aaacccatga atgtgcaaag tctgggatgg aacatcatca ccttcaagga 5580
caaaactgat atccaccgcc tagaaccagt gaaatgtgac acccttttgt gtgacattgg 5640
agagtcatca tcgtcatcgg tcacagaggg ggaaaggacc gtgagagttc ttgatactgt 5700
agaaaaatgg ctggcttgtg gggttgacaa cttctgtgtg aaggtgttag ctccatacat 5760
gccagatgtt cttgagaaac tggaattgct ccaaaggagg tttggcggaa cagtgatcag 5820
gaaccctctc tccaggaatt ccactcatga aatgtactac gtgtctggag cccgcagcaa 5880
tgtcacattt actgtgaacc aaacatcccg cctcctgatg aggagaatga ggcgtccaac 5940
tggaaaagtg accctggagg ctgacgtcat cctcccaatt gggacacgca gtgttgagac 6000
agacaaggga cccctggaca aagaggccat agaagaaagg gttgagagga taaaatctga 6060
gtacatgacc tcttggtttt atgacaatga caacccctac aggacctggc actactgtgg 6120
ctcctatgtc acaaaaacct caggaagtgc ggcgagcatg gtaaatggtg ttattaaaat 6180
tctgacatac ccatgggaca ggatagagga ggtcacaaga atggcaatga ctgacacaac 6240
cccttttgga cagcaaagag tgtttaaaga aaaagttgac accagagcaa aggatccacc 6300
agcgggaact aggaagatca tgaaagttgt caacaggtgg ctgttccgcc acctggccag 6360
agaaaagaac cccagactgt gcacaaagga agaatttatt gcaaaagtcc gaagtcatgc 6420
agccattgga gcttacctgg aagaacaaga acagtggaag actgccaatg aggctgtcca 6480
agacccaaag ttctgggaac tggtggatga agaaaggaag ctgcaccaac aaggcaggtg 6540
tcggacttgt gtgtacaaca tgatggggaa aagagagaag aagctgtcag agtttgggaa 6600
agcaaaggga agccgtgcca tatggtatat gtggctggga gcgcggtatc ttgagtttga 6660
ggccctggga ttcctgaatg aggaccattg ggcttccagg gaaaactcag gaggaggagt 6720
ggaaggcatt ggcttacaat acctaggata tgtgatcaga gacctggctg caatggatgg 6780
tggtggattc tacgcggatg acaccgctgg atgggacacg cgcatcacag aggcagacct 6840
tgatgatgaa caggagatct tgaactacat gagcccacat cacaaaaaac tggcacaagc 6900
agtgatggaa atgacataca agaacaaagt ggtgaaagtg ttgagaccag ccccaggagg 6960
gaaagcctac atggatgtca taagtcgacg agaccagaga ggatccgggc aggtagtgac 7020
ttatgctctg aacaccatca ccaacttgaa agtccaattg atcagaatgg cagaagcaga 7080
gatggtgata catcaccaac atgttcaaga ttgtgatgaa tcagttctga ccaggctgga 7140
ggcatggctc actgagcacg gatgtaacag actgaagagg atggcggtga gtggagacga 7200
ctgtgtggtc cggcccatcg atgacaggtt cggcctggcc ctgtcccatc tcaacgccat 7260
gtccaaggtt agaaaggaca tatctgaatg gcagccatca aaagggtgga atgattggga 7320
gaatgtgccc ttctgttccc accacttcca tgaactacag ctgaaggatg gcaggaggat 7380
tgtggtgcct tgccgagaac aggacgagct cattgggaga ggaagggtgt ctccaggaaa 7440
cggctggatg atcaaggaaa cagcttgcct cagcaaagcc tatgccaaca tgtggtcact 7500
gatgtatttt cacaaaaggg acatgaggct actgtcattg gctgtttcct cagctgttcc 7560
cacctcatgg gttccacaag gacgcacaac atggtcgatt catgggaaag gggagtggat 7620
gaccacggaa gacatgcttg aggtgtggaa cagagtatgg ataaccaaca acccacacat 7680
gcaggacaag acaatggtga aagaatggag agatgtccct tatctaacca agagacaaga 7740
caagctgtgc ggatcactga ttggaatgac caatagggcc acctgggcct cccacatcca 7800
tttggtcatc catcgtatcc gaacgctgat tggacaggag aaatatactg actacctaac 7860
agtcatggac agatattctg tggatgctga cctgcaaccg ggtgagctta tctgaaacac 7920
catctaatag gaataaccgg gatacaaacc acgggtggag aaccggactc cccacaactt 7980
gaaaccggga tataaaccac ggctggagaa ccggactccg cacttaaaat gaaacagaaa 8040
ccgggataaa aactacggat ggagaaccgg actccacaca ttgagacaga agaagttgtc 8100
agcccagaac tccacacgag ttttgccact gctaagctgt gaggcagtgc aggctgggac 8160
agccgacctc caggttgcga aaaacctggt ttctgggacc tcccacccca gagtaaaaag 8220
aacggagcct ccgctaccac cctcccacgt ggtggtagaa agacggggtc tagaggttag 8280
aggagaccct ccagggaaca aatagtggga ccatattgac gccagggaaa gaccggagtg 8340
gttctctgct tttcctccag gggtctgtga gcacagtttg ctcaagaata agcagacctt 8400
tggatgacaa acacaaaac 8419
<210> 95
<211> 9463
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 95
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggctcgtga ggaacccctt ttttgcagtg acagctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatggac ctgctgaggc 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gccgagttca ctgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa aaagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt aagagtgccc atggctctcc aacattttgg atgggaagtc atgaagtaaa 1680
tgggacatgg atgatccaca ccttggaggc attagattac aaggagtgtg agtggccact 1740
gacacatacg attggaacat cagttgaaga gagtgaaatg ttcatgccga gatcaatcgg 1800
aggcccagtt agctctcaca atcatatccc tggatacaag gttcagacga acggaccttg 1860
gatgcaggta ccactagagg tgaagagaga agcttgccca gggactagcg tgatcattga 1920
tggcaactgt gatggacggg gaaaatcaac cagatccacc acggatagcg ggaaaattat 1980
tcctgaatgg tgttgccgct cctgcacaat gccgcctgtg agcttccatg gtagtgatgg 2040
gtgttggtat cccatggaaa ttaggccaag gaaaacgcat gaaagccatc tggtgcgctc 2100
ctgggttaca gctggagaaa tacatgctgt cccttttggt ttggtgagca tgatgatagc 2160
aatggaagtg gtcctaagga aaagacaggg accaaagcaa atgttggttg gaggagtggt 2220
gctcttggga gcaatgctgg tcgggcaagt aactctcctt gatttgctga aactcacagt 2280
ggctgtggga ttgcatttcc atgagatgaa caatggagga gacgccatgt atatggcgtt 2340
gattgctgcc ttttcaatca gaccagggct gctcatcggc tttgggctca ggaccctatg 2400
gagccctcgg gaacgccttg tgctgaccct aggagcagcc atggtggaga ttgccttggg 2460
tggcatgatg ggcggcctgt ggaagtatct aaatgcagtt tctctctgca tcctgacaat 2520
aaatgctgtt gcttctagga aagcatcaaa taccatcttg cccctcatgg ctctgttgac 2580
acctgtcact atggctgagg tgagacttgc cacaatgctc ttttgtaccg tggttatcat 2640
aggggtcctt caccagaact ccaaggacac ctccatgcag aagactatac ctctggtggc 2700
cctcacactc acatcttacc tgggcttgac acaacctttt ttgggcctgt gtgcatttct 2760
ggcaacccgc atatttgggc gaaggagtat cccagtgaat gaggcactcg cagcagctgg 2820
tctagtggga gtgctggcag gactggcttt tcaggagatg gagaacttcc ttggtccgat 2880
tgcagttgga ggaatcctga tgatgctggt tagcgtggct gggagggtgg atgggctaga 2940
gctcaagaag cttggtgaag tttcatggga agaggaggcg gagatcagcg gaagttccgc 3000
ccgctatgat gtggcactca gtgaacaagg ggagttcaag ctgctttctg aagagaaagt 3060
gccatgggac caggttgtga tgacctcgct ggccttggtt ggggctgcca ttcatccatt 3120
tgctcttctg ctggtccttg ctgggtggct gtttcatgtc aggggagcta ggagaagtgg 3180
ggatgtcttg tgggatattc ccactcctaa gatcattgag gaatgtgaac atctggagga 3240
tgggatttat ggcatattcc agtcaacctt cttgggggcc tcccagcgag gagtgggagt 3300
ggcacaggga ggggtgttcc acacaatgtg gcatgtcaca agaggagctt tccttgtcag 3360
gaatggcaag aagttgattc catcttgggc ttcagtaaag gaagaccttg tcgcctatgg 3420
tggctcatgg aagttggaag gcagatggga tggagaggaa gaggtccaat tgatcgctgc 3480
tgttccagga aagaacgtgg tcaacgtcca gacaaaaccg agcttgttca aagtgaggaa 3540
tgggggagaa atcggggctg tcgctcttga ctatccgagt ggcacttcag gatctcctat 3600
tgttaacagg aacggagagg tgattgggct gtacggcaat ggcatccttg tcggtgacaa 3660
ctccttcgtg tccgccatat cccagactga ggtgaaggaa gaaggaaagg aggagctcca 3720
agagatcccg acaatgctaa agaaaggaat gacaactatc cttgattttc atcctggagc 3780
tgggaagaca agacgttttc tcccacagat cttggccgag tgcgcacgga gacgcttgcg 3840
cactcttgtg ttggccccca ccagggttgt tctttctgaa atgaaggagg cttttcacgg 3900
cctggacgtg aaattccaca cacaggcttt ttccgctcac ggcagcggga gagaagtcat 3960
tgatgccatg tgccatgcca ccctaactta caggatgttg gaaccaacta gggttgttaa 4020
ctgggaagtg atcatcatgg atgaagccca ttttttggat ccagctagca tagccgccag 4080
aggttgggca gcgcacagag ctagggcaaa tgaaagtgca acaatcttga tgacagccac 4140
accgcctggg actagtgatg aatttccaca ttcaaatggt gaaatagaag atgttcaaac 4200
ggacataccc agtgagccct ggaacacagg gcatgactgg atcctggctg acaaaaggcc 4260
cacggcatgg ttccttccat ccatcagagc tgcaaatgtc atggctgcct ctttgcgtaa 4320
ggctggaaag agtgtggtgg tcctgaacag gaaaaccttt gagagagaat accccacgat 4380
aaagcagaag aaacctgact ttatattggc cactgacata gctgaaatgg gagccaacct 4440
ttgcgtggag cgagtgctgg attgcaggac ggcttttaag cctgtgcttg tggatgaagg 4500
gaggaaggtg gcaataaaag ggccacttcg catctccgca tcctctgctg ctcaaaggag 4560
ggggcgcatt gggagaaatc ccaacagaga tggagactca tactactatt ctgagcccac 4620
aagtgaagat aatgcccacc acgtctgctg gttggaggcc tcaatgctct tggacaacat 4680
ggaggtgagg ggtggaatgg tcgccccact ctatggcgtt gaaggaacta aaacaccagt 4740
ttcccctggt gaaatgagac tgagggatga ccagaggaaa gtcttcagag aactagtgag 4800
gaattgtgac ctgcccgttt ggctttcgtg gcaagtggcc aaggctggtt tgaagacgaa 4860
tgatcgtaag tggtgttttg aaggccctga ggaacatgag atcttgaatg acagcggtga 4920
aacagtgaag tgcagggctc ctggaggagc aaagaagcct ctgcgcccaa ggtggtgtga 4980
tgaaagggtg tcatctgacc agagtgcgct gtctgaattt attaagtttg ctgaaggtag 5040
gaggggagct gcggaagtgc tagttgtgct gagtgaactc cctgatttcc tggctaaaaa 5100
aggtggagag gcaatggata ccatcagtgt gtttctccac tctgaggaag gctctagggc 5160
ttaccgcaat gcactatcaa tgatgcctga ggcaatgaca atagtcatgc tgtttatact 5220
ggctggacta ctgacatcgg gaatggtcat ctttttcatg tctcccaaag gcatcagtag 5280
aatgtctatg gcgatgggca caatggccgg ctgtggatat ctcatgttcc ttggaggcgt 5340
caaacccact cacatctcct atatcatgct catattcttt gtcctgatgg tggttgtgat 5400
ccccgagcca gggcaacaaa ggtccatcca agacaaccaa gtggcatacc tcattattgg 5460
catcctgacg ctggtttcag tggtggcagc caacgagcta ggcatgctgg agaaaaccaa 5520
agaggacctc tttgggaaga agaacttaat tccatctagt gcttcaccct ggagttggcc 5580
ggatcttgac ctgaagccag gagctgcctg gacagtgtac gttggcattg ttacaatgct 5640
ctctccaatg ttgcaccact ggatcaaagt cgaatatggc aacctgtctc tgtctggaat 5700
agcccagtca gcctcagtcc tttctttcat ggacaagggg ataccattca tgaagatgaa 5760
tatctcggtc ataatactgc tggtcagtgg ctggaattca ataacagtga tgcctctgct 5820
ctgtggcata gggtgcgcca tgctccactg gtctctcatt ttacctggaa tcaaagcgca 5880
gcagtcaaag cttgcacaga gaagggtgtt ccatggcgtt gccaagaacc ctgtggttga 5940
tgggaatcca acagttgaca ttgaggaagc tcctgaaatg cctgcccttt atgagaagaa 6000
actggctcta tatctccttc ttgctctcag cctagcttct gttgccatgt gcagaacgcc 6060
cttttcattg gctgaaggca ttgtcctagc atcagctgcc ttagggccgc tcatagaggg 6120
aaacaccagc cttctttgga atggacccat ggctgtctcc atgacaggag tcatgcgggg 6180
gaattactat gcttttgtgg gagtcatgta caatctatgg aagatgaaaa ctggacgccg 6240
ggggagtgcg aatggaaaaa ctttgggtga agtctggaag agggaactga atctgttgga 6300
caagcaacag tttgagttgt ataaaaggac cgacattgtg gaggtggatc gtgatacggc 6360
acgcaggcat ttggccgaag ggaaggtgga caccggggtg gcggtctcca gggggaccgc 6420
aaagttaagg tggttccatg agcgtggcta tgtcaagctg gaaggtaggg tgattgacct 6480
ggggtgtggc cgcggaggct ggtgttacta cgctgctgcg caaaaggaag tgagtggggt 6540
caaaggattt actcttggaa gagacggcca tgagaaaccc atgaatgtgc aaagtctggg 6600
atggaacatc atcaccttca aggacaaaac tgatatccac cgcctagaac cagtgaaatg 6660
tgacaccctt ttgtgtgaca ttggagagtc atcatcgtca tcggtcacag agggggaaag 6720
gaccgtgaga gttcttgata ctgtagaaaa atggctggct tgtggggttg acaacttctg 6780
tgtgaaggtg ttagctccat acatgccaga tgttcttgag aaactggaat tgctccaaag 6840
gaggtttggc ggaacagtga tcaggaaccc tctctccagg aattccactc atgaaatgta 6900
ctacgtgtct ggagcccgca gcaatgtcac atttactgtg aaccaaacat cccgcctcct 6960
gatgaggaga atgaggcgtc caactggaaa agtgaccctg gaggctgacg tcatcctccc 7020
aattgggaca cgcagtgttg agacagacaa gggacccctg gacaaagagg ccatagaaga 7080
aagggttgag aggataaaat ctgagtacat gacctcttgg ttttatgaca atgacaaccc 7140
ctacaggacc tggcactact gtggctccta tgtcacaaaa acctcaggaa gtgcggcgag 7200
catggtaaat ggtgttatta aaattctgac atacccatgg gacaggatag aggaggtcac 7260
aagaatggca atgactgaca caaccccttt tggacagcaa agagtgttta aagaaaaagt 7320
tgacaccaga gcaaaggatc caccagcggg aactaggaag atcatgaaag ttgtcaacag 7380
gtggctgttc cgccacctgg ccagagaaaa gaaccccaga ctgtgcacaa aggaagaatt 7440
tattgcaaaa gtccgaagtc atgcagccat tggagcttac ctggaagaac aagaacagtg 7500
gaagactgcc aatgaggctg tccaagaccc aaagttctgg gaactggtgg atgaagaaag 7560
gaagctgcac caacaaggca ggtgtcggac ttgtgtgtac aacatgatgg ggaaaagaga 7620
gaagaagctg tcagagtttg ggaaagcaaa gggaagccgt gccatatggt atatgtggct 7680
gggagcgcgg tatcttgagt ttgaggccct gggattcctg aatgaggacc attgggcttc 7740
cagggaaaac tcaggaggag gagtggaagg cattggctta caatacctag gatatgtgat 7800
cagagacctg gctgcaatgg atggtggtgg attctacgcg gatgacaccg ctggatggga 7860
cacgcgcatc acagaggcag accttgatga tgaacaggag atcttgaact acatgagccc 7920
acatcacaaa aaactggcac aagcagtgat ggaaatgaca tacaagaaca aagtggtgaa 7980
agtgttgaga ccagccccag gagggaaagc ctacatggat gtcataagtc gacgagacca 8040
gagaggatcc gggcaggtag tgacttatgc tctgaacacc atcaccaact tgaaagtcca 8100
attgatcaga atggcagaag cagagatggt gatacatcac caacatgttc aagattgtga 8160
tgaatcagtt ctgaccaggc tggaggcatg gctcactgag cacggatgta acagactgaa 8220
gaggatggcg gtgagtggag acgactgtgt ggtccggccc atcgatgaca ggttcggcct 8280
ggccctgtcc catctcaacg ccatgtccaa ggttagaaag gacatatctg aatggcagcc 8340
atcaaaaggg tggaatgatt gggagaatgt gcccttctgt tcccaccact tccatgaact 8400
acagctgaag gatggcagga ggattgtggt gccttgccga gaacaggacg agctcattgg 8460
gagaggaagg gtgtctccag gaaacggctg gatgatcaag gaaacagctt gcctcagcaa 8520
agcctatgcc aacatgtggt cactgatgta ttttcacaaa agggacatga ggctactgtc 8580
attggctgtt tcctcagctg ttcccacctc atgggttcca caaggacgca caacatggtc 8640
gattcatggg aaaggggagt ggatgaccac ggaagacatg cttgaggtgt ggaacagagt 8700
atggataacc aacaacccac acatgcagga caagacaatg gtgaaagaat ggagagatgt 8760
cccttatcta accaagagac aagacaagct gtgcggatca ctgattggaa tgaccaatag 8820
ggccacctgg gcctcccaca tccatttggt catccatcgt atccgaacgc tgattggaca 8880
ggagaaatat actgactacc taacagtcat ggacagatat tctgtggatg ctgacctgca 8940
accgggtgag cttatctgaa acaccatcta ataggaataa ccgggataca aaccacgggt 9000
ggagaaccgg actccccaca acttgaaacc gggatataaa ccacggctgg agaaccggac 9060
tccgcactta aaatgaaaca gaaaccggga taaaaactac ggatggagaa ccggactcca 9120
cacattgaga cagaagaagt tgtcagccca gaactccaca cgagttttgc cactgctaag 9180
ctgtgaggca gtgcaggctg ggacagccga cctccaggtt gcgaaaaacc tggtttctgg 9240
gacctcccac cccagagtaa aaagaacgga gcctccgcta ccaccctccc acgtggtggt 9300
agaaagacgg ggtctagagg ttagaggaga ccctccaggg aacaaatagt gggaccatat 9360
tgacgccagg gaaagaccgg agtggttctc tgcttttcct ccaggggtct gtgagcacag 9420
tttgctcaag aataagcaga cctttggatg acaaacacaa aac 9463
<210> 96
<211> 10351
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 96
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggctcgtga ggaacccctt ttttgcagtg acagctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatggac ctgctgaggc 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gccgagttca ctgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa aaagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt ggaagtggcg gggtgtggag agagatgcat catcttgtcg aatttgaacc 1680
tccgcatgcc gccactatca gagtactggc cctgggaaac caggaaggct ccttgaaaac 1740
agctcttacc ggcgcaatga gggttacaaa ggacacaaat gacaacaacc tttacaaact 1800
acatggtgga catgtttcct gcagagtgaa attgtcagct ttgacactca aggggacatc 1860
ctacaaaatg tgcactgaca aaatgtcttt tgtcaagaac ccaactgaca ctggccatgg 1920
cactgttgtg atgcaggtga aagtgccaaa aggagccccc tgcaagattc cagtgatagt 1980
agctgatgat cttacagcgg caatcaataa aggcattttg gttacagtta accccatcgc 2040
ctcaaccaat gatgatgaag tgctgattga ggtgaaccca ccttttggag acagctacat 2100
tatcgttggg acaggagatt cacgtctcac ttaccagtgg cacaaagagg gaagctcaat 2160
aggaaagttg ttcactcaga ccatgaaagg cgcggaacgc ctggccgtca tgggagacgc 2220
cgcctgggat ttcagctccg ctggagggtt cttcacttcg gttgggaaag gaattcatac 2280
ggtgtttggc tctgcctttc aggggctatt tggcggcttg aactggataa caaaggtcat 2340
catgggggcg gtactcatat gggttggcat caacacaaga aacatgacaa tgtccatgag 2400
catgatcttg gtaggagtga tcatgatgtt tttgtctcta ggagttgggg cggatcaagg 2460
atgcgccatc aactttggca agagagagct caagtgcgga gatggtatct tcatatttag 2520
agactctgat gactggctga acaagtactc atactatcca gaagatcctg tgaagctggc 2580
atcaatagtg aaagaggcat tagattacaa ggagtgtgag tggccactga cacatacgat 2640
tggaacatca gttgaagaga gtgaaatgtt catgccgaga tcaatcggag gcccagttag 2700
ctctcacaat catatccctg gatacaaggt tcagacgaac ggaccttgga tgcaggtacc 2760
actagaggtg aagagagaag cttgcccagg gactagcgtg atcattgatg gcaactgtga 2820
tggacgggga aaatcaacca gatccaccac ggatagcggg aaaattattc ctgaatggtg 2880
ttgccgctcc tgcacaatgc cgcctgtgag cttccatggt agtgatgggt gttggtatcc 2940
catggaaatt aggccaagga aaacgcatga aagccatctg gtgcgctcct gggttacagc 3000
tggagaaata catgctgtcc cttttggttt ggtgagcatg atgatagcaa tggaagtggt 3060
cctaaggaaa agacagggac caaagcaaat gttggttgga ggagtggtgc tcttgggagc 3120
aatgctggtc gggcaagtaa ctctccttga tttgctgaaa ctcacagtgg ctgtgggatt 3180
gcatttccat gagatgaaca atggaggaga cgccatgtat atggcgttga ttgctgcctt 3240
ttcaatcaga ccagggctgc tcatcggctt tgggctcagg accctatgga gccctcggga 3300
acgccttgtg ctgaccctag gagcagccat ggtggagatt gccttgggtg gcatgatggg 3360
cggcctgtgg aagtatctaa atgcagtttc tctctgcatc ctgacaataa atgctgttgc 3420
ttctaggaaa gcatcaaata ccatcttgcc cctcatggct ctgttgacac ctgtcactat 3480
ggctgaggtg agacttgcca caatgctctt ttgtaccgtg gttatcatag gggtccttca 3540
ccagaactcc aaggacacct ccatgcagaa gactatacct ctggtggccc tcacactcac 3600
atcttacctg ggcttgacac aacctttttt gggcctgtgt gcatttctgg caacccgcat 3660
atttgggcga aggagtatcc cagtgaatga ggcactcgca gcagctggtc tagtgggagt 3720
gctggcagga ctggcttttc aggagatgga gaacttcctt ggtccgattg cagttggagg 3780
aatcctgatg atgctggtta gcgtggctgg gagggtggat gggctagagc tcaagaagct 3840
tggtgaagtt tcatgggaag aggaggcgga gatcagcgga agttccgccc gctatgatgt 3900
ggcactcagt gaacaagggg agttcaagct gctttctgaa gagaaagtgc catgggacca 3960
ggttgtgatg acctcgctgg ccttggttgg ggctgccatt catccatttg ctcttctgct 4020
ggtccttgct gggtggctgt ttcatgtcag gggagctagg agaagtgggg atgtcttgtg 4080
ggatattccc actcctaaga tcattgagga atgtgaacat ctggaggatg ggatttatgg 4140
catattccag tcaaccttct tgggggcctc ccagcgagga gtgggagtgg cacagggagg 4200
ggtgttccac acaatgtggc atgtcacaag aggagctttc cttgtcagga atggcaagaa 4260
gttgattcca tcttgggctt cagtaaagga agaccttgtc gcctatggtg gctcatggaa 4320
gttggaaggc agatgggatg gagaggaaga ggtccaattg atcgctgctg ttccaggaaa 4380
gaacgtggtc aacgtccaga caaaaccgag cttgttcaaa gtgaggaatg ggggagaaat 4440
cggggctgtc gctcttgact atccgagtgg cacttcagga tctcctattg ttaacaggaa 4500
cggagaggtg attgggctgt acggcaatgg catccttgtc ggtgacaact ccttcgtgtc 4560
cgccatatcc cagactgagg tgaaggaaga aggaaaggag gagctccaag agatcccgac 4620
aatgctaaag aaaggaatga caactatcct tgattttcat cctggagctg ggaagacaag 4680
acgttttctc ccacagatct tggccgagtg cgcacggaga cgcttgcgca ctcttgtgtt 4740
ggcccccacc agggttgttc tttctgaaat gaaggaggct tttcacggcc tggacgtgaa 4800
attccacaca caggcttttt ccgctcacgg cagcgggaga gaagtcattg atgccatgtg 4860
ccatgccacc ctaacttaca ggatgttgga accaactagg gttgttaact gggaagtgat 4920
catcatggat gaagcccatt ttttggatcc agctagcata gccgccagag gttgggcagc 4980
gcacagagct agggcaaatg aaagtgcaac aatcttgatg acagccacac cgcctgggac 5040
tagtgatgaa tttccacatt caaatggtga aatagaagat gttcaaacgg acatacccag 5100
tgagccctgg aacacagggc atgactggat cctggctgac aaaaggccca cggcatggtt 5160
ccttccatcc atcagagctg caaatgtcat ggctgcctct ttgcgtaagg ctggaaagag 5220
tgtggtggtc ctgaacagga aaacctttga gagagaatac cccacgataa agcagaagaa 5280
acctgacttt atattggcca ctgacatagc tgaaatggga gccaaccttt gcgtggagcg 5340
agtgctggat tgcaggacgg cttttaagcc tgtgcttgtg gatgaaggga ggaaggtggc 5400
aataaaaggg ccacttcgca tctccgcatc ctctgctgct caaaggaggg ggcgcattgg 5460
gagaaatccc aacagagatg gagactcata ctactattct gagcccacaa gtgaagataa 5520
tgcccaccac gtctgctggt tggaggcctc aatgctcttg gacaacatgg aggtgagggg 5580
tggaatggtc gccccactct atggcgttga aggaactaaa acaccagttt cccctggtga 5640
aatgagactg agggatgacc agaggaaagt cttcagagaa ctagtgagga attgtgacct 5700
gcccgtttgg ctttcgtggc aagtggccaa ggctggtttg aagacgaatg atcgtaagtg 5760
gtgttttgaa ggccctgagg aacatgagat cttgaatgac agcggtgaaa cagtgaagtg 5820
cagggctcct ggaggagcaa agaagcctct gcgcccaagg tggtgtgatg aaagggtgtc 5880
atctgaccag agtgcgctgt ctgaatttat taagtttgct gaaggtagga ggggagctgc 5940
ggaagtgcta gttgtgctga gtgaactccc tgatttcctg gctaaaaaag gtggagaggc 6000
aatggatacc atcagtgtgt ttctccactc tgaggaaggc tctagggctt accgcaatgc 6060
actatcaatg atgcctgagg caatgacaat agtcatgctg tttatactgg ctggactact 6120
gacatcggga atggtcatct ttttcatgtc tcccaaaggc atcagtagaa tgtctatggc 6180
gatgggcaca atggccggct gtggatatct catgttcctt ggaggcgtca aacccactca 6240
catctcctat atcatgctca tattctttgt cctgatggtg gttgtgatcc ccgagccagg 6300
gcaacaaagg tccatccaag acaaccaagt ggcatacctc attattggca tcctgacgct 6360
ggtttcagtg gtggcagcca acgagctagg catgctggag aaaaccaaag aggacctctt 6420
tgggaagaag aacttaattc catctagtgc ttcaccctgg agttggccgg atcttgacct 6480
gaagccagga gctgcctgga cagtgtacgt tggcattgtt acaatgctct ctccaatgtt 6540
gcaccactgg atcaaagtcg aatatggcaa cctgtctctg tctggaatag cccagtcagc 6600
ctcagtcctt tctttcatgg acaaggggat accattcatg aagatgaata tctcggtcat 6660
aatactgctg gtcagtggct ggaattcaat aacagtgatg cctctgctct gtggcatagg 6720
gtgcgccatg ctccactggt ctctcatttt acctggaatc aaagcgcagc agtcaaagct 6780
tgcacagaga agggtgttcc atggcgttgc caagaaccct gtggttgatg ggaatccaac 6840
agttgacatt gaggaagctc ctgaaatgcc tgccctttat gagaagaaac tggctctata 6900
tctccttctt gctctcagcc tagcttctgt tgccatgtgc agaacgccct tttcattggc 6960
tgaaggcatt gtcctagcat cagctgcctt agggccgctc atagagggaa acaccagcct 7020
tctttggaat ggacccatgg ctgtctccat gacaggagtc atgcggggga attactatgc 7080
ttttgtggga gtcatgtaca atctatggaa gatgaaaact ggacgccggg ggagtgcgaa 7140
tggaaaaact ttgggtgaag tctggaagag ggaactgaat ctgttggaca agcaacagtt 7200
tgagttgtat aaaaggaccg acattgtgga ggtggatcgt gatacggcac gcaggcattt 7260
ggccgaaggg aaggtggaca ccggggtggc ggtctccagg gggaccgcaa agttaaggtg 7320
gttccatgag cgtggctatg tcaagctgga aggtagggtg attgacctgg ggtgtggccg 7380
cggaggctgg tgttactacg ctgctgcgca aaaggaagtg agtggggtca aaggatttac 7440
tcttggaaga gacggccatg agaaacccat gaatgtgcaa agtctgggat ggaacatcat 7500
caccttcaag gacaaaactg atatccaccg cctagaacca gtgaaatgtg acaccctttt 7560
gtgtgacatt ggagagtcat catcgtcatc ggtcacagag ggggaaagga ccgtgagagt 7620
tcttgatact gtagaaaaat ggctggcttg tggggttgac aacttctgtg tgaaggtgtt 7680
agctccatac atgccagatg ttcttgagaa actggaattg ctccaaagga ggtttggcgg 7740
aacagtgatc aggaaccctc tctccaggaa ttccactcat gaaatgtact acgtgtctgg 7800
agcccgcagc aatgtcacat ttactgtgaa ccaaacatcc cgcctcctga tgaggagaat 7860
gaggcgtcca actggaaaag tgaccctgga ggctgacgtc atcctcccaa ttgggacacg 7920
cagtgttgag acagacaagg gacccctgga caaagaggcc atagaagaaa gggttgagag 7980
gataaaatct gagtacatga cctcttggtt ttatgacaat gacaacccct acaggacctg 8040
gcactactgt ggctcctatg tcacaaaaac ctcaggaagt gcggcgagca tggtaaatgg 8100
tgttattaaa attctgacat acccatggga caggatagag gaggtcacaa gaatggcaat 8160
gactgacaca accccttttg gacagcaaag agtgtttaaa gaaaaagttg acaccagagc 8220
aaaggatcca ccagcgggaa ctaggaagat catgaaagtt gtcaacaggt ggctgttccg 8280
ccacctggcc agagaaaaga accccagact gtgcacaaag gaagaattta ttgcaaaagt 8340
ccgaagtcat gcagccattg gagcttacct ggaagaacaa gaacagtgga agactgccaa 8400
tgaggctgtc caagacccaa agttctggga actggtggat gaagaaagga agctgcacca 8460
acaaggcagg tgtcggactt gtgtgtacaa catgatgggg aaaagagaga agaagctgtc 8520
agagtttggg aaagcaaagg gaagccgtgc catatggtat atgtggctgg gagcgcggta 8580
tcttgagttt gaggccctgg gattcctgaa tgaggaccat tgggcttcca gggaaaactc 8640
aggaggagga gtggaaggca ttggcttaca atacctagga tatgtgatca gagacctggc 8700
tgcaatggat ggtggtggat tctacgcgga tgacaccgct ggatgggaca cgcgcatcac 8760
agaggcagac cttgatgatg aacaggagat cttgaactac atgagcccac atcacaaaaa 8820
actggcacaa gcagtgatgg aaatgacata caagaacaaa gtggtgaaag tgttgagacc 8880
agccccagga gggaaagcct acatggatgt cataagtcga cgagaccaga gaggatccgg 8940
gcaggtagtg acttatgctc tgaacaccat caccaacttg aaagtccaat tgatcagaat 9000
ggcagaagca gagatggtga tacatcacca acatgttcaa gattgtgatg aatcagttct 9060
gaccaggctg gaggcatggc tcactgagca cggatgtaac agactgaaga ggatggcggt 9120
gagtggagac gactgtgtgg tccggcccat cgatgacagg ttcggcctgg ccctgtccca 9180
tctcaacgcc atgtccaagg ttagaaagga catatctgaa tggcagccat caaaagggtg 9240
gaatgattgg gagaatgtgc ccttctgttc ccaccacttc catgaactac agctgaagga 9300
tggcaggagg attgtggtgc cttgccgaga acaggacgag ctcattggga gaggaagggt 9360
gtctccagga aacggctgga tgatcaagga aacagcttgc ctcagcaaag cctatgccaa 9420
catgtggtca ctgatgtatt ttcacaaaag ggacatgagg ctactgtcat tggctgtttc 9480
ctcagctgtt cccacctcat gggttccaca aggacgcaca acatggtcga ttcatgggaa 9540
aggggagtgg atgaccacgg aagacatgct tgaggtgtgg aacagagtat ggataaccaa 9600
caacccacac atgcaggaca agacaatggt gaaagaatgg agagatgtcc cttatctaac 9660
caagagacaa gacaagctgt gcggatcact gattggaatg accaataggg ccacctgggc 9720
ctcccacatc catttggtca tccatcgtat ccgaacgctg attggacagg agaaatatac 9780
tgactaccta acagtcatgg acagatattc tgtggatgct gacctgcaac cgggtgagct 9840
tatctgaaac accatctaat aggaataacc gggatacaaa ccacgggtgg agaaccggac 9900
tccccacaac ttgaaaccgg gatataaacc acggctggag aaccggactc cgcacttaaa 9960
atgaaacaga aaccgggata aaaactacgg atggagaacc ggactccaca cattgagaca 10020
gaagaagttg tcagcccaga actccacacg agttttgcca ctgctaagct gtgaggcagt 10080
gcaggctggg acagccgacc tccaggttgc gaaaaacctg gtttctggga cctcccaccc 10140
cagagtaaaa agaacggagc ctccgctacc accctcccac gtggtggtag aaagacgggg 10200
tctagaggtt agaggagacc ctccagggaa caaatagtgg gaccatattg acgccaggga 10260
aagaccggag tggttctctg cttttcctcc aggggtctgt gagcacagtt tgctcaagaa 10320
taagcagacc tttggatgac aaacacaaaa c 10351
<210> 97
<211> 10850
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 97
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggctcgtga ggaacccctt ttttgcagtg acagctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatggac ctgctgaggc 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gccgagttca ctgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa aaagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt ggaagtggcg gggtgtggag agagatgcat catcttgtcg aatttgaacc 1680
tccgcatgcc gccactatca gagtactggc cctgggaaac caggaaggct ccttgaaaac 1740
agctcttacc ggcgcaatga gggttacaaa ggacacaaat gacaacaacc tttacaaact 1800
acatggtgga catgtttcct gcagagtgaa attgtcagct ttgacactca aggggacatc 1860
ctacaaaatg tgcactgaca aaatgtcttt tgtcaagaac ccaactgaca ctggccatgg 1920
cactgttgtg atgcaggtga aagtgccaaa aggagccccc tgcaagattc cagtgatagt 1980
agctgatgat cttacagcgg caatcaataa aggcattttg gttacagtta accccatcgc 2040
ctcaaccaat gatgatgaag tgctgattga ggtgaaccca ccttttggag acagctacat 2100
tatcgttggg acaggagatt cacgtctcac ttaccagtgg cacaaagagg gaagctcaat 2160
aggaaagttg ttcactcaga ccatgaaagg cgcggaacgc ctggccgtca tgggagacgc 2220
cgcctgggat ttcagctccg ctggagggtt cttcacttcg gttgggaaag gaattcatac 2280
ggtgtttggc tctgcctttc aggggctatt tggcggcttg aactggataa caaaggtcat 2340
catgggggcg gtactcatat gggttggcat caacacaaga aacatgacaa tgtccatgag 2400
catgatcttg gtaggagtga tcatgatgtt tttgtctcta ggagttgggg cggatcaagg 2460
atgcgccatc aactttggca agagagagct caagtgcgga gatggtatct tcatatttag 2520
agactctgat gactggctga acaagtactc atactatcca gaagatcctg tgaagctggc 2580
atcaatagtg aaagcctctt ttgaagaagg gaagtgtggc ctaaattcag ttgactccct 2640
tgagcatgag atgtggagaa gcagggcaga tgagatcaat gccattcttg aggaaaacga 2700
ggtggacatt tctgttgtcg tgcaggatcc aaagaatgtt taccagagag gaactcatcc 2760
attttccaga attcgggatg gtctgcagta tggttggaag acttggggta agaaccttgt 2820
gttctcccca gggaggaaga atggaagctt catcatagat ggaaagtcca ggaaagaatg 2880
cccgttttca aaccgggtct ggaattcttt ccagatagag gagtttggga cgggagtgtt 2940
caccacacgc gtgtacatgg acgcagtctt tgaatacacc atagactgcg atggatctat 3000
cttgggtgca gcggtgaacg gaaaaaagag tgcccatggc tctccaacat tttggatggg 3060
aagtcatgaa gtaaatggga catggatgat ccacaccttg gaggcattag attacaagga 3120
gtgtgagtgg ccactgacac atacgattgg aacatcagtt gaagagagtg aaatgttcat 3180
gccgagatca atcggaggcc cagttagctc tcacaatcat atccctggat acaaggttca 3240
gacgaacgga ccttggatgc aggtaccact agaggtgaag agagaagctt gcccagggac 3300
tagcgtgatc attgatggca actgtgatgg acggggaaaa tcaaccagat ccaccacgga 3360
tagcgggaaa attattcctg aatggtgttg ccgctcctgc acaatgccgc ctgtgagctt 3420
ccatggtagt gatgggtgtt ggtatcccat ggaaattagg ccaaggaaaa cgcatgaaag 3480
ccatctggtg cgctcctggg ttacagctgg agaaatacat gctgtccctt ttggtttggt 3540
gagcatgatg atagcaatgg aagtggtcct aaggaaaaga cagggaccaa agcaaatgtt 3600
ggttggagga gtggtgctct tgggagcaat gctggtcggg caagtaactc tccttgattt 3660
gctgaaactc acagtggctg tgggattgca tttccatgag atgaacaatg gaggagacgc 3720
catgtatatg gcgttgattg ctgccttttc aatcagacca gggctgctca tcggctttgg 3780
gctcaggacc ctatggagcc ctcgggaacg ccttgtgctg accctaggag cagccatggt 3840
ggagattgcc ttgggtggca tgatgggcgg cctgtggaag tatctaaatg cagtttctct 3900
ctgcatcctg acaataaatg ctgttgcttc taggaaagca tcaaatacca tcttgcccct 3960
catggctctg ttgacacctg tcactatggc tgaggtgaga cttgccacaa tgctcttttg 4020
taccgtggtt atcatagggg tccttcacca gaactccaag gacacctcca tgcagaagac 4080
tatacctctg gtggccctca cactcacatc ttacctgggc ttgacacaac cttttttggg 4140
cctgtgtgca tttctggcaa cccgcatatt tgggcgaagg agtatcccag tgaatgaggc 4200
actcgcagca gctggtctag tgggagtgct ggcaggactg gcttttcagg agatggagaa 4260
cttccttggt ccgattgcag ttggaggaat cctgatgatg ctggttagcg tggctgggag 4320
ggtggatggg ctagagctca agaagcttgg tgaagtttca tgggaagagg aggcggagat 4380
cagcggaagt tccgcccgct atgatgtggc actcagtgaa caaggggagt tcaagctgct 4440
ttctgaagag aaagtgccat gggaccaggt tgtgatgacc tcgctggcct tggttggggc 4500
tgccattcat ccatttgctc ttctgctggt ccttgctggg tggctgtttc atgtcagggg 4560
agctaggaga agtggggatg tcttgtggga tattcccact cctaagatca ttgaggaatg 4620
tgaacatctg gaggatggga tttatggcat attccagtca accttcttgg gggcctccca 4680
gcgaggagtg ggagtggcac agggaggggt gttccacaca atgtggcatg tcacaagagg 4740
agctttcctt gtcaggaatg gcaagaagtt gattccatct tgggcttcag taaaggaaga 4800
ccttgtcgcc tatggtggct catggaagtt ggaaggcaga tgggatggag aggaagaggt 4860
ccaattgatc gctgctgttc caggaaagaa cgtggtcaac gtccagacaa aaccgagctt 4920
gttcaaagtg aggaatgggg gagaaatcgg ggctgtcgct cttgactatc cgagtggcac 4980
ttcaggatct cctattgtta acaggaacgg agaggtgatt gggctgtacg gcaatggcat 5040
ccttgtcggt gacaactcct tcgtgtccgc catatcccag actgaggtga aggaagaagg 5100
aaaggaggag ctccaagaga tcccgacaat gctaaagaaa ggaatgacaa ctatccttga 5160
ttttcatcct ggagctggga agacaagacg ttttctccca cagatcttgg ccgagtgcgc 5220
acggagacgc ttgcgcactc ttgtgttggc ccccaccagg gttgttcttt ctgaaatgaa 5280
ggaggctttt cacggcctgg acgtgaaatt ccacacacag gctttttccg ctcacggcag 5340
cgggagagaa gtcattgatg ccatgtgcca tgccacccta acttacagga tgttggaacc 5400
aactagggtt gttaactggg aagtgatcat catggatgaa gcccattttt tggatccagc 5460
tagcatagcc gccagaggtt gggcagcgca cagagctagg gcaaatgaaa gtgcaacaat 5520
cttgatgaca gccacaccgc ctgggactag tgatgaattt ccacattcaa atggtgaaat 5580
agaagatgtt caaacggaca tacccagtga gccctggaac acagggcatg actggatcct 5640
ggctgacaaa aggcccacgg catggttcct tccatccatc agagctgcaa atgtcatggc 5700
tgcctctttg cgtaaggctg gaaagagtgt ggtggtcctg aacaggaaaa cctttgagag 5760
agaatacccc acgataaagc agaagaaacc tgactttata ttggccactg acatagctga 5820
aatgggagcc aacctttgcg tggagcgagt gctggattgc aggacggctt ttaagcctgt 5880
gcttgtggat gaagggagga aggtggcaat aaaagggcca cttcgcatct ccgcatcctc 5940
tgctgctcaa aggagggggc gcattgggag aaatcccaac agagatggag actcatacta 6000
ctattctgag cccacaagtg aagataatgc ccaccacgtc tgctggttgg aggcctcaat 6060
gctcttggac aacatggagg tgaggggtgg aatggtcgcc ccactctatg gcgttgaagg 6120
aactaaaaca ccagtttccc ctggtgaaat gagactgagg gatgaccaga ggaaagtctt 6180
cagagaacta gtgaggaatt gtgacctgcc cgtttggctt tcgtggcaag tggccaaggc 6240
tggtttgaag acgaatgatc gtaagtggtg ttttgaaggc cctgaggaac atgagatctt 6300
gaatgacagc ggtgaaacag tgaagtgcag ggctcctgga ggagcaaaga agcctctgcg 6360
cccaaggtgg tgtgatgaaa gggtgtcatc tgaccagagt gcgctgtctg aatttattaa 6420
gtttgctgaa ggtaggaggg gagctgcgga agtgctagtt gtgctgagtg aactccctga 6480
tttcctggct aaaaaaggtg gagaggcaat ggataccatc agtgtgtttc tccactctga 6540
ggaaggctct agggcttacc gcaatgcact atcaatgatg cctgaggcaa tgacaatagt 6600
catgctgttt atactggctg gactactgac atcgggaatg gtcatctttt tcatgtctcc 6660
caaaggcatc agtagaatgt ctatggcgat gggcacaatg gccggctgtg gatatctcat 6720
gttccttgga ggcgtcaaac ccactcacat ctcctatatc atgctcatat tctttgtcct 6780
gatggtggtt gtgatccccg agccagggca acaaaggtcc atccaagaca accaagtggc 6840
atacctcatt attggcatcc tgacgctggt ttcagtggtg gcagccaacg agctaggcat 6900
gctggagaaa accaaagagg acctctttgg gaagaagaac ttaattccat ctagtgcttc 6960
accctggagt tggccggatc ttgacctgaa gccaggagct gcctggacag tgtacgttgg 7020
cattgttaca atgctctctc caatgttgca ccactggatc aaagtcgaat atggcaacct 7080
gtctctgtct ggaatagccc agtcagcctc agtcctttct ttcatggaca aggggatacc 7140
attcatgaag atgaatatct cggtcataat actgctggtc agtggctgga attcaataac 7200
agtgatgcct ctgctctgtg gcatagggtg cgccatgctc cactggtctc tcattttacc 7260
tggaatcaaa gcgcagcagt caaagcttgc acagagaagg gtgttccatg gcgttgccaa 7320
gaaccctgtg gttgatggga atccaacagt tgacattgag gaagctcctg aaatgcctgc 7380
cctttatgag aagaaactgg ctctatatct ccttcttgct ctcagcctag cttctgttgc 7440
catgtgcaga acgccctttt cattggctga aggcattgtc ctagcatcag ctgccttagg 7500
gccgctcata gagggaaaca ccagccttct ttggaatgga cccatggctg tctccatgac 7560
aggagtcatg cgggggaatt actatgcttt tgtgggagtc atgtacaatc tatggaagat 7620
gaaaactgga cgccggggga gtgcgaatgg aaaaactttg ggtgaagtct ggaagaggga 7680
actgaatctg ttggacaagc aacagtttga gttgtataaa aggaccgaca ttgtggaggt 7740
ggatcgtgat acggcacgca ggcatttggc cgaagggaag gtggacaccg gggtggcggt 7800
ctccaggggg accgcaaagt taaggtggtt ccatgagcgt ggctatgtca agctggaagg 7860
tagggtgatt gacctggggt gtggccgcgg aggctggtgt tactacgctg ctgcgcaaaa 7920
ggaagtgagt ggggtcaaag gatttactct tggaagagac ggccatgaga aacccatgaa 7980
tgtgcaaagt ctgggatgga acatcatcac cttcaaggac aaaactgata tccaccgcct 8040
agaaccagtg aaatgtgaca cccttttgtg tgacattgga gagtcatcat cgtcatcggt 8100
cacagagggg gaaaggaccg tgagagttct tgatactgta gaaaaatggc tggcttgtgg 8160
ggttgacaac ttctgtgtga aggtgttagc tccatacatg ccagatgttc ttgagaaact 8220
ggaattgctc caaaggaggt ttggcggaac agtgatcagg aaccctctct ccaggaattc 8280
cactcatgaa atgtactacg tgtctggagc ccgcagcaat gtcacattta ctgtgaacca 8340
aacatcccgc ctcctgatga ggagaatgag gcgtccaact ggaaaagtga ccctggaggc 8400
tgacgtcatc ctcccaattg ggacacgcag tgttgagaca gacaagggac ccctggacaa 8460
agaggccata gaagaaaggg ttgagaggat aaaatctgag tacatgacct cttggtttta 8520
tgacaatgac aacccctaca ggacctggca ctactgtggc tcctatgtca caaaaacctc 8580
aggaagtgcg gcgagcatgg taaatggtgt tattaaaatt ctgacatacc catgggacag 8640
gatagaggag gtcacaagaa tggcaatgac tgacacaacc ccttttggac agcaaagagt 8700
gtttaaagaa aaagttgaca ccagagcaaa ggatccacca gcgggaacta ggaagatcat 8760
gaaagttgtc aacaggtggc tgttccgcca cctggccaga gaaaagaacc ccagactgtg 8820
cacaaaggaa gaatttattg caaaagtccg aagtcatgca gccattggag cttacctgga 8880
agaacaagaa cagtggaaga ctgccaatga ggctgtccaa gacccaaagt tctgggaact 8940
ggtggatgaa gaaaggaagc tgcaccaaca aggcaggtgt cggacttgtg tgtacaacat 9000
gatggggaaa agagagaaga agctgtcaga gtttgggaaa gcaaagggaa gccgtgccat 9060
atggtatatg tggctgggag cgcggtatct tgagtttgag gccctgggat tcctgaatga 9120
ggaccattgg gcttccaggg aaaactcagg aggaggagtg gaaggcattg gcttacaata 9180
cctaggatat gtgatcagag acctggctgc aatggatggt ggtggattct acgcggatga 9240
caccgctgga tgggacacgc gcatcacaga ggcagacctt gatgatgaac aggagatctt 9300
gaactacatg agcccacatc acaaaaaact ggcacaagca gtgatggaaa tgacatacaa 9360
gaacaaagtg gtgaaagtgt tgagaccagc cccaggaggg aaagcctaca tggatgtcat 9420
aagtcgacga gaccagagag gatccgggca ggtagtgact tatgctctga acaccatcac 9480
caacttgaaa gtccaattga tcagaatggc agaagcagag atggtgatac atcaccaaca 9540
tgttcaagat tgtgatgaat cagttctgac caggctggag gcatggctca ctgagcacgg 9600
atgtaacaga ctgaagagga tggcggtgag tggagacgac tgtgtggtcc ggcccatcga 9660
tgacaggttc ggcctggccc tgtcccatct caacgccatg tccaaggtta gaaaggacat 9720
atctgaatgg cagccatcaa aagggtggaa tgattgggag aatgtgccct tctgttccca 9780
ccacttccat gaactacagc tgaaggatgg caggaggatt gtggtgcctt gccgagaaca 9840
ggacgagctc attgggagag gaagggtgtc tccaggaaac ggctggatga tcaaggaaac 9900
agcttgcctc agcaaagcct atgccaacat gtggtcactg atgtattttc acaaaaggga 9960
catgaggcta ctgtcattgg ctgtttcctc agctgttccc acctcatggg ttccacaagg 10020
acgcacaaca tggtcgattc atgggaaagg ggagtggatg accacggaag acatgcttga 10080
ggtgtggaac agagtatgga taaccaacaa cccacacatg caggacaaga caatggtgaa 10140
agaatggaga gatgtccctt atctaaccaa gagacaagac aagctgtgcg gatcactgat 10200
tggaatgacc aatagggcca cctgggcctc ccacatccat ttggtcatcc atcgtatccg 10260
aacgctgatt ggacaggaga aatatactga ctacctaaca gtcatggaca gatattctgt 10320
ggatgctgac ctgcaaccgg gtgagcttat ctgaaacacc atctaatagg aataaccggg 10380
atacaaacca cgggtggaga accggactcc ccacaacttg aaaccgggat ataaaccacg 10440
gctggagaac cggactccgc acaaacagaa accgggataa aaactacgga tggagaaccg 10500
gactccacac attgagacag aagaagttgt cagcccagaa ctccacacga gttttgccac 10560
tgctaagctg tgaggcagtg caggctggga cagccgacct ccaggttgcg aaaaacctgg 10620
tttctgggac ctcccacccc agagtaaaaa gaacggagcc tccgctacca ccctcccacg 10680
tggtggtaga aagacggggt ctagaggtta gaggagaccc tccagggaac aaatagtggg 10740
accatattga cgccagggaa agaccggagt ggttctctgc ttttcctcca ggggtctgtg 10800
agcacagttt gctcaagaat aagcagacct ttggatgaca aacacaaaac 10850
<210> 98
<211> 10827
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 98
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggctcgtga ggaacccctt ttttgcagtg acagctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatggac ctgctgaggc 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gccgagttca ctgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa aaagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt ggaagtggcg gggtgtggag agagatgcat catcttgtcg aatttgaacc 1680
tccgcatgcc gccactatca gagtactggc cctgggaaac caggaaggct ccttgaaaac 1740
agctcttacc ggcgcaatga gggttacaaa ggacacaaat gacaacaacc tttacaaact 1800
acatggtgga catgtttcct gcagagtgaa attgtcagct ttgacactca aggggacatc 1860
ctacaaaatg tgcactgaca aaatgtcttt tgtcaagaac ccaactgaca ctggccatgg 1920
cactgttgtg atgcaggtga aagtgccaaa aggagccccc tgcaagattc cagtgatagt 1980
agctgatgat cttacagcgg caatcaataa aggcattttg gttacagtta accccatcgc 2040
ctcaaccaat gatgatgaag tgctgattga ggtgaaccca ccttttggag acagctacat 2100
tatcgttggg acaggagatt cacgtctcac ttaccagtgg cacaaagagg gaagctcaat 2160
aggaaagttg ttcactcaga ccatgaaagg cgcggaacgc ctggccgtca tgggagacgc 2220
cgcctgggat ttcagctccg ctggagggtt cttcacttcg gttgggaaag gaattcatac 2280
ggtgtttggc tctgcctttc aggggctatt tggcggcttg aactggataa caaaggtcat 2340
catgggggcg gtactcatat gggttggcat caacacaaga aacatgacaa tgtccatgag 2400
catgatcttg gtaggagtga tcatgatgtt tttgtctcta ggagttgggg cggatcaagg 2460
atgcgccatc aactttggca agagagagct caagtgcgga gatggtatct tcatatttag 2520
agactctgat gactggctga acaagtactc atactatcca gaagatcctg tgaagctggc 2580
atcaatagtg aaagcctctt ttgaagaagg gaagtgtggc ctaaattcag ttgactccct 2640
tgagcatgag atgtggagaa gcagggcaga tgagatcaat gccattcttg aggaaaacga 2700
ggtggacatt tctgttgtcg tgcaggatcc aaagaatgtt taccagagag gaactcatcc 2760
attttccaga attcgggatg gtctgcagta tggttggaag acttggggta agaaccttgt 2820
gttctcccca gggaggaaga atggaagctt catcatagat ggaaagtcca ggaaagaatg 2880
cccgttttca aaccgggtct ggaattcttt ccagatagag gagtttggga cgggagtgtt 2940
caccacacgc gtgtacatgg acgcagtctt tgaatacacc atagactgcg atggatctat 3000
cttgggtgca gcggtgaacg gaaaaaagag tgcccatggc tctccaacat tttggatggg 3060
aagtcatgaa gtaaatggga catggatgat ccacaccttg gaggcattag attacaagga 3120
gtgtgagtgg ccactgacac atacgattgg aacatcagtt gaagagagtg aaatgttcat 3180
gccgagatca atcggaggcc cagttagctc tcacaatcat atccctggat acaaggttca 3240
gacgaacgga ccttggatgc aggtaccact agaggtgaag agagaagctt gcccagggac 3300
tagcgtgatc attgatggca actgtgatgg acggggaaaa tcaaccagat ccaccacgga 3360
tagcgggaaa attattcctg aatggtgttg ccgctcctgc acaatgccgc ctgtgagctt 3420
ccatggtagt gatgggtgtt ggtatcccat ggaaattagg ccaaggaaaa cgcatgaaag 3480
ccatctggtg cgctcctggg ttacagctgg agaaatacat gctgtccctt ttggtttggt 3540
gagcatgatg atagcaatgg aagtggtcct aaggaaaaga cagggaccaa agcaaatgtt 3600
ggttggagga gtggtgctct tgggagcaat gctggtcggg caagtaactc tccttgattt 3660
gctgaaactc acagtggctg tgggattgca tttccatgag atgaacaatg gaggagacgc 3720
catgtatatg gcgttgattg ctgccttttc aatcagacca gggctgctca tcggctttgg 3780
gctcaggacc ctatggagcc ctcgggaacg ccttgtgctg accctaggag cagccatggt 3840
ggagattgcc ttgggtggca tgatgggcgg cctgtggaag tatctaaatg cagtttctct 3900
ctgcatcctg acaataaatg ctgttgcttc taggaaagca tcaaatacca tcttgcccct 3960
catggctctg ttgacacctg tcactatggc tgaggtgaga cttgccacaa tgctcttttg 4020
taccgtggtt atcatagggg tccttcacca gaactccaag gacacctcca tgcagaagac 4080
tatacctctg gtggccctca cactcacatc ttacctgggc ttgacacaac cttttttggg 4140
cctgtgtgca tttctggcaa cccgcatatt tgggcgaagg agtatcccag tgaatgaggc 4200
actcgcagca gctggtctag tgggagtgct ggcaggactg gcttttcagg agatggagaa 4260
cttccttggt ccgattgcag ttggaggaat cctgatgatg ctggttagcg tggctgggag 4320
ggtggatggg ctagagctca agaagcttgg tgaagtttca tgggaagagg aggcggagat 4380
cagcggaagt tccgcccgct atgatgtggc actcagtgaa caaggggagt tcaagctgct 4440
ttctgaagag aaagtgccat gggaccaggt tgtgatgacc tcgctggcct tggttggggc 4500
tgccattcat ccatttgctc ttctgctggt ccttgctggg tggctgtttc atgtcagggg 4560
agctaggaga agtggggatg tcttgtggga tattcccact cctaagatca ttgaggaatg 4620
tgaacatctg gaggatggga tttatggcat attccagtca accttcttgg gggcctccca 4680
gcgaggagtg ggagtggcac agggaggggt gttccacaca atgtggcatg tcacaagagg 4740
agctttcctt gtcaggaatg gcaagaagtt gattccatct tgggcttcag taaaggaaga 4800
ccttgtcgcc tatggtggct catggaagtt ggaaggcaga tgggatggag aggaagaggt 4860
ccaattgatc gctgctgttc caggaaagaa cgtggtcaac gtccagacaa aaccgagctt 4920
gttcaaagtg aggaatgggg gagaaatcgg ggctgtcgct cttgactatc cgagtggcac 4980
ttcaggatct cctattgtta acaggaacgg agaggtgatt gggctgtacg gcaatggcat 5040
ccttgtcggt gacaactcct tcgtgtccgc catatcccag actgaggtga aggaagaagg 5100
aaaggaggag ctccaagaga tcccgacaat gctaaagaaa ggaatgacaa ctatccttga 5160
ttttcatcct ggagctggga agacaagacg ttttctccca cagatcttgg ccgagtgcgc 5220
acggagacgc ttgcgcactc ttgtgttggc ccccaccagg gttgttcttt ctgaaatgaa 5280
ggaggctttt cacggcctgg acgtgaaatt ccacacacag gctttttccg ctcacggcag 5340
cgggagagaa gtcattgatg ccatgtgcca tgccacccta acttacagga tgttggaacc 5400
aactagggtt gttaactggg aagtgatcat catggatgaa gcccattttt tggatccagc 5460
tagcatagcc gccagaggtt gggcagcgca cagagctagg gcaaatgaaa gtgcaacaat 5520
cttgatgaca gccacaccgc ctgggactag tgatgaattt ccacattcaa atggtgaaat 5580
agaagatgtt caaacggaca tacccagtga gccctggaac acagggcatg actggatcct 5640
ggctgacaaa aggcccacgg catggttcct tccatccatc agagctgcaa atgtcatggc 5700
tgcctctttg cgtaaggctg gaaagagtgt ggtggtcctg aacaggaaaa cctttgagag 5760
agaatacccc acgataaagc agaagaaacc tgactttata ttggccactg acatagctga 5820
aatgggagcc aacctttgcg tggagcgagt gctggattgc aggacggctt ttaagcctgt 5880
gcttgtggat gaagggagga aggtggcaat aaaagggcca cttcgcatct ccgcatcctc 5940
tgctgctcaa aggagggggc gcattgggag aaatcccaac agagatggag actcatacta 6000
ctattctgag cccacaagtg aagataatgc ccaccacgtc tgctggttgg aggcctcaat 6060
gctcttggac aacatggagg tgaggggtgg aatggtcgcc ccactctatg gcgttgaagg 6120
aactaaaaca ccagtttccc ctggtgaaat gagactgagg gatgaccaga ggaaagtctt 6180
cagagaacta gtgaggaatt gtgacctgcc cgtttggctt tcgtggcaag tggccaaggc 6240
tggtttgaag acgaatgatc gtaagtggtg ttttgaaggc cctgaggaac atgagatctt 6300
gaatgacagc ggtgaaacag tgaagtgcag ggctcctgga ggagcaaaga agcctctgcg 6360
cccaaggtgg tgtgatgaaa gggtgtcatc tgaccagagt gcgctgtctg aatttattaa 6420
gtttgctgaa ggtaggaggg gagctgcgga agtgctagtt gtgctgagtg aactccctga 6480
tttcctggct aaaaaaggtg gagaggcaat ggataccatc agtgtgtttc tccactctga 6540
ggaaggctct agggcttacc gcaatgcact atcaatgatg cctgaggcaa tgacaatagt 6600
catgctgttt atactggctg gactactgac atcgggaatg gtcatctttt tcatgtctcc 6660
caaaggcatc agtagaatgt ctatggcgat gggcacaatg gccggctgtg gatatctcat 6720
gttccttgga ggcgtcaaac ccactcacat ctcctatatc atgctcatat tctttgtcct 6780
gatggtggtt gtgatccccg agccagggca acaaaggtcc atccaagaca accaagtggc 6840
atacctcatt attggcatcc tgacgctggt ttcagtggtg gcagccaacg agctaggcat 6900
gctggagaaa accaaagagg acctctttgg gaagaagaac ttaattccat ctagtgcttc 6960
accctggagt tggccggatc ttgacctgaa gccaggagct gcctggacag tgtacgttgg 7020
cattgttaca atgctctctc caatgttgca ccactggatc aaagtcgaat atggcaacct 7080
gtctctgtct ggaatagccc agtcagcctc agtcctttct ttcatggaca aggggatacc 7140
attcatgaag atgaatatct cggtcataat actgctggtc agtggctgga attcaataac 7200
agtgatgcct ctgctctgtg gcatagggtg cgccatgctc cactggtctc tcattttacc 7260
tggaatcaaa gcgcagcagt caaagcttgc acagagaagg gtgttccatg gcgttgccaa 7320
gaaccctgtg gttgatggga atccaacagt tgacattgag gaagctcctg aaatgcctgc 7380
cctttatgag aagaaactgg ctctatatct ccttcttgct ctcagcctag cttctgttgc 7440
catgtgcaga acgccctttt cattggctga aggcattgtc ctagcatcag ctgccttagg 7500
gccgctcata gagggaaaca ccagccttct ttggaatgga cccatggctg tctccatgac 7560
aggagtcatg cgggggaatt actatgcttt tgtgggagtc atgtacaatc tatggaagat 7620
gaaaactgga cgccggggga gtgcgaatgg aaaaactttg ggtgaagtct ggaagaggga 7680
actgaatctg ttggacaagc aacagtttga gttgtataaa aggaccgaca ttgtggaggt 7740
ggatcgtgat acggcacgca ggcatttggc cgaagggaag gtggacaccg gggtggcggt 7800
ctccaggggg accgcaaagt taaggtggtt ccatgagcgt ggctatgtca agctggaagg 7860
tagggtgatt gacctggggt gtggccgcgg aggctggtgt tactacgctg ctgcgcaaaa 7920
ggaagtgagt ggggtcaaag gatttactct tggaagagac ggccatgaga aacccatgaa 7980
tgtgcaaagt ctgggatgga acatcatcac cttcaaggac aaaactgata tccaccgcct 8040
agaaccagtg aaatgtgaca cccttttgtg tgacattgga gagtcatcat cgtcatcggt 8100
cacagagggg gaaaggaccg tgagagttct tgatactgta gaaaaatggc tggcttgtgg 8160
ggttgacaac ttctgtgtga aggtgttagc tccatacatg ccagatgttc ttgagaaact 8220
ggaattgctc caaaggaggt ttggcggaac agtgatcagg aaccctctct ccaggaattc 8280
cactcatgaa atgtactacg tgtctggagc ccgcagcaat gtcacattta ctgtgaacca 8340
aacatcccgc ctcctgatga ggagaatgag gcgtccaact ggaaaagtga ccctggaggc 8400
tgacgtcatc ctcccaattg ggacacgcag tgttgagaca gacaagggac ccctggacaa 8460
agaggccata gaagaaaggg ttgagaggat aaaatctgag tacatgacct cttggtttta 8520
tgacaatgac aacccctaca ggacctggca ctactgtggc tcctatgtca caaaaacctc 8580
aggaagtgcg gcgagcatgg taaatggtgt tattaaaatt ctgacatacc catgggacag 8640
gatagaggag gtcacaagaa tggcaatgac tgacacaacc ccttttggac agcaaagagt 8700
gtttaaagaa aaagttgaca ccagagcaaa ggatccacca gcgggaacta ggaagatcat 8760
gaaagttgtc aacaggtggc tgttccgcca cctggccaga gaaaagaacc ccagactgtg 8820
cacaaaggaa gaatttattg caaaagtccg aagtcatgca gccattggag cttacctgga 8880
agaacaagaa cagtggaaga ctgccaatga ggctgtccaa gacccaaagt tctgggaact 8940
ggtggatgaa gaaaggaagc tgcaccaaca aggcaggtgt cggacttgtg tgtacaacat 9000
gatggggaaa agagagaaga agctgtcaga gtttgggaaa gcaaagggaa gccgtgccat 9060
atggtatatg tggctgggag cgcggtatct tgagtttgag gccctgggat tcctgaatga 9120
ggaccattgg gcttccaggg aaaactcagg aggaggagtg gaaggcattg gcttacaata 9180
cctaggatat gtgatcagag acctggctgc aatggatggt ggtggattct acgcggatga 9240
caccgctgga tgggacacgc gcatcacaga ggcagacctt gatgatgaac aggagatctt 9300
gaactacatg agcccacatc acaaaaaact ggcacaagca gtgatggaaa tgacatacaa 9360
gaacaaagtg gtgaaagtgt tgagaccagc cccaggaggg aaagcctaca tggatgtcat 9420
aagtcgacga gaccagagag gatccgggca ggtagtgact tatgctctga acaccatcac 9480
caacttgaaa gtccaattga tcagaatggc agaagcagag atggtgatac atcaccaaca 9540
tgttcaagat tgtgatgaat cagttctgac caggctggag gcatggctca ctgagcacgg 9600
atgtaacaga ctgaagagga tggcggtgag tggagacgac tgtgtggtcc ggcccatcga 9660
tgacaggttc ggcctggccc tgtcccatct caacgccatg tccaaggtta gaaaggacat 9720
atctgaatgg cagccatcaa aagggtggaa tgattgggag aatgtgccct tctgttccca 9780
ccacttccat gaactacagc tgaaggatgg caggaggatt gtggtgcctt gccgagaaca 9840
ggacgagctc attgggagag gaagggtgtc tccaggaaac ggctggatga tcaaggaaac 9900
agcttgcctc agcaaagcct atgccaacat gtggtcactg atgtattttc acaaaaggga 9960
catgaggcta ctgtcattgg ctgtttcctc agctgttccc acctcatggg ttccacaagg 10020
acgcacaaca tggtcgattc atgggaaagg ggagtggatg accacggaag acatgcttga 10080
ggtgtggaac agagtatgga taaccaacaa cccacacatg caggacaaga caatggtgaa 10140
agaatggaga gatgtccctt atctaaccaa gagacaagac aagctgtgcg gatcactgat 10200
tggaatgacc aatagggcca cctgggcctc ccacatccat ttggtcatcc atcgtatccg 10260
aacgctgatt ggacaggaga aatatactga ctacctaaca gtcatggaca gatattctgt 10320
ggatgctgac ctgcaaccgg gtgagcttat ctgaaacacc atctaatagg aataaccggg 10380
atacaaacca cgggtggaga accggactcc ccacaacttg aaaccgggat ataaaccacg 10440
gctggagaac cggactccgc acttaaaatg aaacagaaac cgggataaaa actacagaag 10500
aagttgtcag cccagaactc cacacgagtt ttgccactgc taagctgtga ggcagtgcag 10560
gctgggacag ccgacctcca ggttgcgaaa aacctggttt ctgggacctc ccaccccaga 10620
gtaaaaagaa cggagcctcc gctaccaccc tcccacgtgg tggtagaaag acggggtcta 10680
gaggttagag gagaccctcc agggaacaaa tagtgggacc atattgacgc cagggaaaga 10740
ccggagtggt tctctgcttt tcctccaggg gtctgtgagc acagtttgct caagaataag 10800
cagacctttg gatgacaaac acaaaac 10827
<210> 99
<211> 8070
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 99
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttaaat gggacatgga tgatccacac 300
cttggaggca ttagattaca aggagtgtga gtggccactg acacatacga ttggaacatc 360
agttgaagag agtgaaatgt tcatgccgag atcaatcgga ggcccagtta gctctcacaa 420
tcatatccct ggatacaagg ttcagacgaa cggaccttgg atgcaggtac cactagaagt 480
gaagagagaa gcttgcccag ggactagcgt gatcattgat ggcaactgtg atggacgggg 540
aaaatcaacc agatccacca cggatagcgg gaaagttatt cctgaatggt gttgccgctc 600
ctgcacaatg ccgcctgtga gcttccatgg tagtgatggg tgttggtatc ccatggaaat 660
taggccaagg aaaacgcatg aaagccatct ggtgcgctcc tgggttacag ctggagaaat 720
acatgctgtc ccttttggtt tggtgagcat gatgatagca atggaagtgg tcctaaggaa 780
aagacaggga ccaaagcaaa tgttggttgg aggagtagtg ctcttgggag caatgctggt 840
cgggcaagta actctccttg atttgctgaa actcacagtg gctgtgggat tgcatttcca 900
tgagatgaac aatggaggag acgccatgta tatggcgttg attgctgcct tttcaatcag 960
accagggctg ctcatcggct ttgggctcag gaccctatgg agccctcggg aacgccttgt 1020
gctgacccta ggagcagcca tggtggagat tgccttgggt ggcgtgatgg gcggcctgtg 1080
gaagtatcta aatgcagttt ctctctgcat cctgacaata aatgctgttg cttctaggaa 1140
agcatcaaat accatcttgc ccctcatggc tctgttgaca cctgtcacta tggctgaggt 1200
gagacttgcc gcaatgttct tttgtgccat ggttatcata ggggtccttc accagaattt 1260
caaggacacc tccatgcaga agactatacc tctggtggcc ctcacactca catcttacct 1320
gggcttgaca caaccttttt tgggcctgtg tgcatttctg gcaacccgca tatttgggcg 1380
aaggagtatc ccagtgaatg aggcactcgc agcagctggt ctagtgggag tgctggcagg 1440
actggctttt caggagatgg agaacttcct tggtccgatt gcagttggag gactcctgat 1500
gatgctggtt agcgtggctg ggagggtgga tgggctagag ctcaagaagc ttggtgaagt 1560
ttcatgggaa gaggaggcgg agatcagcgg gagttccgcc cgctatgatg tggcactcag 1620
tgaacaaggg gagttcaagc tgctttctga agagaaagtg ccatgggacc aggttgtgat 1680
gacctcgctg gccttggttg gggctgccct ccatccattt gctcttctgc tggtccttgc 1740
tgggtggctg tttcatgtca ggggagctag gagaagtggg gatgtcttgt gggatattcc 1800
cactcctaag atcatcgagg aatgtgaaca tctggaggat gggatttatg gcatattcca 1860
gtcaaccttc ttgggggcct cccagcgagg agtgggagtg gcacagggag gggtgttcca 1920
cacaatgtgg catgtcacaa gaggagcttt ccttgtcagg aatggcaaga agttgattcc 1980
atcttgggct tcagtaaagg aagaccttgt cgcctatggt ggctcatgga agttggaagg 2040
cagatgggat ggagaggaag aggtccagtt gatcgcggct gttccaggaa agaacgtggt 2100
caacgtccag acaaaaccga gcttgttcaa agtgaggaat gggggagaaa tcggggctgt 2160
cgctcttgac tatccgagtg gcacttcagg atctcctatt gttaacagga acggagaggt 2220
gattgggctg tacggcaatg gcatccttgt cggtgacaac tccttcgtgt ccgccatatc 2280
ccagactgag gtgaaggaag aaggaaagga ggagctccaa gagatcccga caatgctaaa 2340
gaaaggaatg acaactgtcc ttgattttca tcctggagct gggaagacaa gacgtttcct 2400
cccacagatc ttggccgagt gcgcacggag acgcttgcgc actcttgtgt tggcccccac 2460
cagggttgtt ctttctgaaa tgaaggaggc ttttcacggc ctggacgtga aattccacac 2520
acaggctttt tccgctcacg gcagcgggag agaagtcatt gatgccatgt gccatgccac 2580
cctaacttac aggatgttgg aaccaactag ggttgttaac tgggaagtga tcattatgga 2640
tgaagcccat tttttggatc cagctagcat agccgctaga ggttgggcag cgcacagagc 2700
tagggcaaat gaaagtgcaa caatcttgat gacagccaca ccgcctggga ctagtgatga 2760
atttccacat tcaaatggtg aaatagaaga tgttcaaacg gacataccca gtgagccctg 2820
gaacacaggg catgactgga tcctggctga caaaaggccc acggcatggt tccttccatc 2880
catcagagct gcaaatgtca tggctgcctc tttgcgtaag gctggaaaga gtgtggtggt 2940
cctgaacagg aaaacctttg agagagaata ccccacgata aagcagaaga aacctgactt 3000
tatattggcc actgacatag ctgaaatggg agccaacctt tgcgtggagc gagtgctgga 3060
ttgcaggacg gcttttaagc ctgtgcttgt ggatgaaggg aggaaggtgg caataaaagg 3120
gccacttcgt atctccgcat cctctgctgc tcaaaggagg gggcgcattg ggagaaatcc 3180
caacagagat ggagactcat actactattc tgagcctaca agtgaaaata atgcccacca 3240
cgtctgctgg ttggaggcct caatgctctt ggacaacatg gaggtgaggg gtggaatggt 3300
cgccccactc tatggcgttg aaggaactaa aacaccagtt tcccctggtg aaatgagact 3360
gagggatgac cagaggaaag tcttcagaga actagtgagg aattgtgacc tgcccgtttg 3420
gctttcgtgg caagtggcca aggctggttt gaagacgaat gatcgtaagt ggtgttttga 3480
aggccctgag gaacatgaga tcttgaatga cagcggtgaa acagtgaagt gcagggctcc 3540
tggaggagca aagaagcctc tgcgcccaag gtggtgtgat gaaagggtgt catctgacca 3600
gagtgcgctg tctgaattta ttaagtttgc tgaaggtagg aggggagctg ctgaagtgct 3660
agttgtgctg agtgaactcc ctgatttcct ggctaaaaaa ggtggagagg caatggatac 3720
catcagtgtg ttcctccact ctgaggaagg ctctagggct taccgcaatg cactatcaat 3780
gatgcctgag gcaatgacaa tagtcatgct gtttatactg gctggactac tgacatcggg 3840
aatggtcatc tttttcatgt ctcccaaagg catcagtaga atgtctatgg cgatgggcac 3900
aatggccggc tgtggatatc tcatgttcct tggaggcgtc aaacccactc acatctccta 3960
tgtcatgctc atattctttg tcctgatggt ggttgtgatc cccgagccag ggcaacaaag 4020
gtccatccaa gacaaccaag tggcatacct cattattggc atcctgacgc tggtttcagc 4080
ggtggcagcc aacgagctag gcatgctgga gaaaaccaaa gaggacctct ttgggaagaa 4140
gaacttaatt ccatctagtg cttcaccctg gagttggccg gatcttgacc tgaagccagg 4200
agctgcctgg acagtgtacg ttggcattgt tacaatgctc tctccaatgt tgcaccactg 4260
gatcaaagtc gaatatggca acctgtctct gtctggaata gcccagtcag cctcagtcct 4320
ttctttcatg gacaagggga taccattcat gaagatgaat atctcggtca taatgctgct 4380
ggtcagtggc tggaattcaa taacagtgat gcctctgctc tgtggcatag ggtgcgccat 4440
gctccactgg tctctcattt tacctggaat caaagcgcag cagtcaaagc ttgcacagag 4500
aagggtgttc catggcgttg ccaagaaccc tgtggttgat gggaatccaa cagttgacat 4560
tgaggaagct cctgaaatgc ctgcccttta tgagaagaaa ctggctctat atctccttct 4620
tgctctcagc ctagcttctg ttgccatgtg cagaacgccc ttttcattgg ctgaaggcat 4680
tgtcctagca tcagctgcct tagggccgct catagaggga aacaccagcc ttctttggaa 4740
tggacccatg gctgtctcca tgacaggagt catgaggggg aatcactatg cttttgtggg 4800
agtcatgtac aatctatgga agatgaaaac tggacgccgg gggagcgcga atggaaaaac 4860
tttgggtgaa gtctggaaga gggaactgaa tctgttggac aagcgacagt ttgagttgta 4920
taaaaggacc gacattgtgg aggtggatcg tgatacggca cgcaggcatt tggccgaagg 4980
gaaggtggac accggggtgg cggtctccag ggggaccgca aagttaaggt ggttccatga 5040
gcgtggctat gtcaagctgg aaggtagggt gattgacctg gggtgtggcc gcggaggctg 5100
gtgttactac gctgctgcgc aaaaggaagt gagtggggtc aaaggattta ctcttggaag 5160
agacggccat gagaaaccca tgaatgtgca aagtctggga tggaacatca tcaccttcaa 5220
ggacaaaact gatatccacc gcctagaacc agtgaaatgt gacacccttt tgtgtgacat 5280
tggagagtca tcatcgtcat cggtcacaga gggggaaagg accgtgagag ttcttgatac 5340
tgtagaaaaa tggctggctt gtggggttga caacttctgt gtgaaggtgt tagctccata 5400
catgccagat gttcttgaga aactggaatt gctccaaagg aggtttggcg gaacagtgat 5460
caggaaccct ctctccagga attccactca tgaaatgtac tacgtgtctg gagcccgcag 5520
caatgtcaca tttactgtga accaaacatc ccgcctcctg atgaggagaa tgaggcgtcc 5580
aactggaaaa gtgaccctgg aggctgacgt catcctccca attgggacac gcagtgttga 5640
gacagacaag ggacccctgg acaaagaggc catagaagaa agggttgaga ggataaaatc 5700
tgagtacatg acctcttggt tttatgacaa tgacaacccc tacaggacct ggcactactg 5760
tggctcctat gtcacaaaaa cctcaggaag tgcggcgagc atggtaaatg gtgttattaa 5820
aattctgaca tatccatggg acaggataga ggaggtcaca agaatggcaa tgactgacac 5880
aacccctttt ggacagcaaa gagtgtttaa agaaaaagtt gacaccagag caaaggatcc 5940
accagcggga actaggaaga tcatgaaagt tgtcaacagg tggctgttcc gccacctggc 6000
cagagaaaag aaccccagac tgtgcacaaa ggaagaattt attgcaaaag tccgaagtca 6060
tgcagccatt ggagcttacc tggaagaaca agaacagtgg aagactgcca atgaggctgt 6120
ccaagaccca aagttctggg aactggtgga tgaagaaagg aagctgcacc aacaaggcag 6180
gtgtcggact tgtgtgtaca acatgatggg gaaaagagag aagaagctgt cagagtttgg 6240
gaaagcaaag ggaagccgtg ccatatggta tatgtggctg ggagcgcggt atcttgagtt 6300
tgaggccctg ggattcctga atgaggacca ttgggcttcc agggaaaact caggaggagg 6360
agtggaaggc attggcttac aatacctagg atatgtgatc agagacctgg ctgcaatgga 6420
tggtggtgga ttctacgcgg atgacaccgc tggatgggac acgcgcatca cagaggcaga 6480
ccttgatgat gaacaggaga tcttgaacta catgagccca catcacaaaa aactggcaca 6540
agcagtgatg gaaatgacat acaagaacaa agtggtgaaa gtgttgagac cagccccagg 6600
agggaaagcc tacatggatg tcataagtcg acgagaccag agaggatccg ggcaggtagt 6660
gacttatgct ctgaacacca tcaccaactt gaaagtccaa ttgatcagaa tggcagaagc 6720
agagatggtg atacatcacc aacatgttca agattgtgat gaatcagttc tgaccaggct 6780
ggaggcatgg ctcactgagc acggatgtga cagactgaag aggatggcgg tgagtggaga 6840
cgactgtgtg gtccggccca tcgatgacag gttcggcctg gccctgtccc atctcaacgc 6900
catgtccaag gttagaaagg acatatctga atggcagcca tcaaaagggt ggaatgattg 6960
ggagaatgtg cccttctgtt cccaccactt ccatgaacta cagctgaagg atggcaggag 7020
gattgtggtg ccttgccgag aacaggacga gctcattggg agaggaaggg tgtctccagg 7080
aaacggctgg atgatcaagg aaacagcttg cctcagcaaa gcctatgcca acatgtggtc 7140
actgatgtat tttcacaaaa gggacatgag gctactgtca ttggctgttt cctcagctgt 7200
tcccacctca tgggttccac aaggacgcac aacatggtcg attcatggga aaggggagtg 7260
gatgaccacg gaagacatgc ttgaggtgtg gaacagagta tggataacca acaacccaca 7320
catgcaggac aagacaatgg tgaaaaaatg gagagatgtc ccttatctaa ccaagagaca 7380
agacaagctg tgcggatcac tgattggaat gaccaatagg gccacctggg cctcccacat 7440
ccatttagtc atccatcgta tccgaacgct gattggacag gagaaataca ctgactacct 7500
aacagtcatg gacaggtatt ctgtggatgc tgacctgcaa ctgggtgagc ttatctgaaa 7560
caccatctaa caggaataac cgggatacaa accacgggtg gagaaccgga ctccccacaa 7620
cctgaaaccg ggatataaac cacggctgga gaaccggact ccgcacttaa aatgaaacag 7680
aaaccgggat aaaaactacg gatggagaac cggactccac acattgagac agaagaagtt 7740
gtcagcccag aaccccacac gagttttgcc actgctaagc tgtgaggcag tgcaggctgg 7800
gacagccgac ctccaggttg cgaaaaacct ggtttctggg acctcccacc ccagagtaaa 7860
aagaacggag cctccgctac caccctccca cgtggtggta gaaagacggg gtctagaggt 7920
tagaggagac cctccaggga acaaatagtg ggaccatatt gacgccaggg aaagaccgga 7980
gtggttctct gcttttcctc cagaggtctg tgagcacagt ttgctcaaga ataagcagac 8040
ctttggatga caaacacaaa accactcgag 8070
<210> 100
<211> 8142
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 100
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagata ttcctgaatg 660
gtgttgccgc tcctgcacaa tgccgcctgt gagcttccat ggtagtgatg ggtgttggta 720
tcccatggaa attaggccaa ggaaaacgca tgaaagccat ctggtgcgct cctgggttac 780
agctggagaa atacatgctg tcccttttgg tttggtgagc atgatgatag caatggaagt 840
ggtcctaagg aaaagacagg gaccaaagca aatgttggtt ggaggagtag tgctcttggg 900
agcaatgctg gtcgggcaag taactctcct tgatttgctg aaactcacag tggctgtggg 960
attgcatttc catgagatga acaatggagg agacgccatg tatatggcgt tgattgctgc 1020
cttttcaatc agaccagggc tgctcatcgg ctttgggctc aggaccctat ggagccctcg 1080
ggaacgcctt gtgctgaccc taggagcagc catggtggag attgccttgg gtggcgtgat 1140
gggcggcctg tggaagtatc taaatgcagt ttctctctgc atcctgacaa taaatgctgt 1200
tgcttctagg aaagcatcaa ataccatctt gcccctcatg gctctgttga cacctgtcac 1260
tatggctgag gtgagacttg ccgcaatgtt cttttgtgcc atggttatca taggggtcct 1320
tcaccagaat ttcaaggaca cctccatgca gaagactata cctctggtgg ccctcacact 1380
cacatcttac ctgggcttga cacaaccttt tttgggcctg tgtgcatttc tggcaacccg 1440
catatttggg cgaaggagta tcccagtgaa tgaggcactc gcagcagctg gtctagtggg 1500
agtgctggca ggactggctt ttcaggagat ggagaacttc cttggtccga ttgcagttgg 1560
aggactcctg atgatgctgg ttagcgtggc tgggagggtg gatgggctag agctcaagaa 1620
gcttggtgaa gtttcatggg aagaggaggc ggagatcagc gggagttccg cccgctatga 1680
tgtggcactc agtgaacaag gggagttcaa gctgctttct gaagagaaag tgccatggga 1740
ccaggttgtg atgacctcgc tggccttggt tggggctgcc ctccatccat ttgctcttct 1800
gctggtcctt gctgggtggc tgtttcatgt caggggagct aggagaagtg gggatgtctt 1860
gtgggatatt cccactccta agatcatcga ggaatgtgaa catctggagg atgggattta 1920
tggcatattc cagtcaacct tcttgggggc ctcccagcga ggagtgggag tggcacaggg 1980
aggggtgttc cacacaatgt ggcatgtcac aagaggagct ttccttgtca ggaatggcaa 2040
gaagttgatt ccatcttggg cttcagtaaa ggaagacctt gtcgcctatg gtggctcatg 2100
gaagttggaa ggcagatggg atggagagga agaggtccag ttgatcgcgg ctgttccagg 2160
aaagaacgtg gtcaacgtcc agacaaaacc gagcttgttc aaagtgagga atgggggaga 2220
aatcggggct gtcgctcttg actatccgag tggcacttca ggatctccta ttgttaacag 2280
gaacggagag gtgattgggc tgtacggcaa tggcatcctt gtcggtgaca actccttcgt 2340
gtccgccata tcccagactg aggtgaagga agaaggaaag gaggagctcc aagagatccc 2400
gacaatgcta aagaaaggaa tgacaactgt ccttgatttt catcctggag ctgggaagac 2460
aagacgtttc ctcccacaga tcttggccga gtgcgcacgg agacgcttgc gcactcttgt 2520
gttggccccc accagggttg ttctttctga aatgaaggag gcttttcacg gcctggacgt 2580
gaaattccac acacaggctt tttccgctca cggcagcggg agagaagtca ttgatgccat 2640
gtgccatgcc accctaactt acaggatgtt ggaaccaact agggttgtta actgggaagt 2700
gatcattatg gatgaagccc attttttgga tccagctagc atagccgcta gaggttgggc 2760
agcgcacaga gctagggcaa atgaaagtgc aacaatcttg atgacagcca caccgcctgg 2820
gactagtgat gaatttccac attcaaatgg tgaaatagaa gatgttcaaa cggacatacc 2880
cagtgagccc tggaacacag ggcatgactg gatcctggct gacaaaaggc ccacggcatg 2940
gttccttcca tccatcagag ctgcaaatgt catggctgcc tctttgcgta aggctggaaa 3000
gagtgtggtg gtcctgaaca ggaaaacctt tgagagagaa taccccacga taaagcagaa 3060
gaaacctgac tttatattgg ccactgacat agctgaaatg ggagccaacc tttgcgtgga 3120
gcgagtgctg gattgcagga cggcttttaa gcctgtgctt gtggatgaag ggaggaaggt 3180
ggcaataaaa gggccacttc gtatctccgc atcctctgct gctcaaagga gggggcgcat 3240
tgggagaaat cccaacagag atggagactc atactactat tctgagccta caagtgaaaa 3300
taatgcccac cacgtctgct ggttggaggc ctcaatgctc ttggacaaca tggaggtgag 3360
gggtggaatg gtcgccccac tctatggcgt tgaaggaact aaaacaccag tttcccctgg 3420
tgaaatgaga ctgagggatg accagaggaa agtcttcaga gaactagtga ggaattgtga 3480
cctgcccgtt tggctttcgt ggcaagtggc caaggctggt ttgaagacga atgatcgtaa 3540
gtggtgtttt gaaggccctg aggaacatga gatcttgaat gacagcggtg aaacagtgaa 3600
gtgcagggct cctggaggag caaagaagcc tctgcgccca aggtggtgtg atgaaagggt 3660
gtcatctgac cagagtgcgc tgtctgaatt tattaagttt gctgaaggta ggaggggagc 3720
tgctgaagtg ctagttgtgc tgagtgaact ccctgatttc ctggctaaaa aaggtggaga 3780
ggcaatggat accatcagtg tgttcctcca ctctgaggaa ggctctaggg cttaccgcaa 3840
tgcactatca atgatgcctg aggcaatgac aatagtcatg ctgtttatac tggctggact 3900
actgacatcg ggaatggtca tctttttcat gtctcccaaa ggcatcagta gaatgtctat 3960
ggcgatgggc acaatggccg gctgtggata tctcatgttc cttggaggcg tcaaacccac 4020
tcacatctcc tatgtcatgc tcatattctt tgtcctgatg gtggttgtga tccccgagcc 4080
agggcaacaa aggtccatcc aagacaacca agtggcatac ctcattattg gcatcctgac 4140
gctggtttca gcggtggcag ccaacgagct aggcatgctg gagaaaacca aagaggacct 4200
ctttgggaag aagaacttaa ttccatctag tgcttcaccc tggagttggc cggatcttga 4260
cctgaagcca ggagctgcct ggacagtgta cgttggcatt gttacaatgc tctctccaat 4320
gttgcaccac tggatcaaag tcgaatatgg caacctgtct ctgtctggaa tagcccagtc 4380
agcctcagtc ctttctttca tggacaaggg gataccattc atgaagatga atatctcggt 4440
cataatgctg ctggtcagtg gctggaattc aataacagtg atgcctctgc tctgtggcat 4500
agggtgcgcc atgctccact ggtctctcat tttacctgga atcaaagcgc agcagtcaaa 4560
gcttgcacag agaagggtgt tccatggcgt tgccaagaac cctgtggttg atgggaatcc 4620
aacagttgac attgaggaag ctcctgaaat gcctgccctt tatgagaaga aactggctct 4680
atatctcctt cttgctctca gcctagcttc tgttgccatg tgcagaacgc ccttttcatt 4740
ggctgaaggc attgtcctag catcagctgc cttagggccg ctcatagagg gaaacaccag 4800
ccttctttgg aatggaccca tggctgtctc catgacagga gtcatgaggg ggaatcacta 4860
tgcttttgtg ggagtcatgt acaatctatg gaagatgaaa actggacgcc gggggagcgc 4920
gaatggaaaa actttgggtg aagtctggaa gagggaactg aatctgttgg acaagcgaca 4980
gtttgagttg tataaaagga ccgacattgt ggaggtggat cgtgatacgg cacgcaggca 5040
tttggccgaa gggaaggtgg acaccggggt ggcggtctcc agggggaccg caaagttaag 5100
gtggttccat gagcgtggct atgtcaagct ggaaggtagg gtgattgacc tggggtgtgg 5160
ccgcggaggc tggtgttact acgctgctgc gcaaaaggaa gtgagtgggg tcaaaggatt 5220
tactcttgga agagacggcc atgagaaacc catgaatgtg caaagtctgg gatggaacat 5280
catcaccttc aaggacaaaa ctgatatcca ccgcctagaa ccagtgaaat gtgacaccct 5340
tttgtgtgac attggagagt catcatcgtc atcggtcaca gagggggaaa ggaccgtgag 5400
agttcttgat actgtagaaa aatggctggc ttgtggggtt gacaacttct gtgtgaaggt 5460
gttagctcca tacatgccag atgttcttga gaaactggaa ttgctccaaa ggaggtttgg 5520
cggaacagtg atcaggaacc ctctctccag gaattccact catgaaatgt actacgtgtc 5580
tggagcccgc agcaatgtca catttactgt gaaccaaaca tcccgcctcc tgatgaggag 5640
aatgaggcgt ccaactggaa aagtgaccct ggaggctgac gtcatcctcc caattgggac 5700
acgcagtgtt gagacagaca agggacccct ggacaaagag gccatagaag aaagggttga 5760
gaggataaaa tctgagtaca tgacctcttg gttttatgac aatgacaacc cctacaggac 5820
ctggcactac tgtggctcct atgtcacaaa aacctcagga agtgcggcga gcatggtaaa 5880
tggtgttatt aaaattctga catatccatg ggacaggata gaggaggtca caagaatggc 5940
aatgactgac acaacccctt ttggacagca aagagtgttt aaagaaaaag ttgacaccag 6000
agcaaaggat ccaccagcgg gaactaggaa gatcatgaaa gttgtcaaca ggtggctgtt 6060
ccgccacctg gccagagaaa agaaccccag actgtgcaca aaggaagaat ttattgcaaa 6120
agtccgaagt catgcagcca ttggagctta cctggaagaa caagaacagt ggaagactgc 6180
caatgaggct gtccaagacc caaagttctg ggaactggtg gatgaagaaa ggaagctgca 6240
ccaacaaggc aggtgtcgga cttgtgtgta caacatgatg gggaaaagag agaagaagct 6300
gtcagagttt gggaaagcaa agggaagccg tgccatatgg tatatgtggc tgggagcgcg 6360
gtatcttgag tttgaggccc tgggattcct gaatgaggac cattgggctt ccagggaaaa 6420
ctcaggagga ggagtggaag gcattggctt acaataccta ggatatgtga tcagagacct 6480
ggctgcaatg gatggtggtg gattctacgc ggatgacacc gctggatggg acacgcgcat 6540
cacagaggca gaccttgatg atgaacagga gatcttgaac tacatgagcc cacatcacaa 6600
aaaactggca caagcagtga tggaaatgac atacaagaac aaagtggtga aagtgttgag 6660
accagcccca ggagggaaag cctacatgga tgtcataagt cgacgagacc agagaggatc 6720
cgggcaggta gtgacttatg ctctgaacac catcaccaac ttgaaagtcc aattgatcag 6780
aatggcagaa gcagagatgg tgatacatca ccaacatgtt caagattgtg atgaatcagt 6840
tctgaccagg ctggaggcat ggctcactga gcacggatgt gacagactga agaggatggc 6900
ggtgagtgga gacgactgtg tggtccggcc catcgatgac aggttcggcc tggccctgtc 6960
ccatctcaac gccatgtcca aggttagaaa ggacatatct gaatggcagc catcaaaagg 7020
gtggaatgat tgggagaatg tgcccttctg ttcccaccac ttccatgaac tacagctgaa 7080
ggatggcagg aggattgtgg tgccttgccg agaacaggac gagctcattg ggagaggaag 7140
ggtgtctcca ggaaacggct ggatgatcaa ggaaacagct tgcctcagca aagcctatgc 7200
caacatgtgg tcactgatgt attttcacaa aagggacatg aggctactgt cattggctgt 7260
ttcctcagct gttcccacct catgggttcc acaaggacgc acaacatggt cgattcatgg 7320
gaaaggggag tggatgacca cggaagacat gcttgaggtg tggaacagag tatggataac 7380
caacaaccca cacatgcagg acaagacaat ggtgaaaaaa tggagagatg tcccttatct 7440
aaccaagaga caagacaagc tgtgcggatc actgattgga atgaccaata gggccacctg 7500
ggcctcccac atccatttag tcatccatcg tatccgaacg ctgattggac aggagaaata 7560
cactgactac ctaacagtca tggacaggta ttctgtggat gctgacctgc aactgggtga 7620
gcttatctga aacaccatct aacaggaata accgggatac aaaccacggg tggagaaccg 7680
gactccccac aacctgaaac cgggatataa accacggctg gagaaccgga ctccgcactt 7740
aaaatgaaac agaaaccggg ataaaaacta cggatggaga accggactcc acacattgag 7800
acagaagaag ttgtcagccc agaaccccac acgagttttg ccactgctaa gctgtgaggc 7860
agtgcaggct gggacagccg acctccaggt tgcgaaaaac ctggtttctg ggacctccca 7920
ccccagagta aaaagaacgg agcctccgct accaccctcc cacgtggtgg tagaaagacg 7980
gggtctagag gttagaggag accctccagg gaacaaatag tgggaccata ttgacgccag 8040
ggaaagaccg gagtggttct ctgcttttcc tccagaggtc tgtgagcaca gtttgctcaa 8100
gaataagcag acctttggat gacaaacaca aaaccactcg ag 8142
<210> 101
<211> 8718
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 101
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aagagtttgg 780
gacgggagtg ttcaccacac gcgtgtacat ggacgcagtc tttgaataca ccatagactg 840
cgatggatct atcttgggtg cagcggtgaa cggaaaaaag agtgcccatg gctctccaac 900
attttggatg ggaagtcatg aagtaaatgg gacatggatg atccacacct tggaggcatt 960
agattacaag gagtgtgagt ggccactgac acatacgatt ggaacatcag ttgaagagag 1020
tgaaatgttc atgccgagat caatcggagg cccagttagc tctcacaatc atatccctgg 1080
atacaaggtt cagacgaacg gaccttggat gcaggtacca ctagaagtga agagagaagc 1140
ttgcccaggg actagcgtga tcattgatgg caactgtgat ggacggggaa aatcaaccag 1200
atccaccacg gatagcggga aagttattcc tgaatggtgt tgccgctcct gcacaatgcc 1260
gcctgtgagc ttccatggta gtgatgggtg ttggtatccc atggaaatta ggccaaggaa 1320
aacgcatgaa agccatctgg tgcgctcctg ggttacagct ggagaaatac atgctgtccc 1380
ttttggtttg gtgagcatga tgatagcaat ggaagtggtc ctaaggaaaa gacagggacc 1440
aaagcaaatg ttggttggag gagtagtgct cttgggagca atgctggtcg ggcaagtaac 1500
tctccttgat ttgctgaaac tcacagtggc tgtgggattg catttccatg agatgaacaa 1560
tggaggagac gccatgtata tggcgttgat tgctgccttt tcaatcagac cagggctgct 1620
catcggcttt gggctcagga ccctatggag ccctcgggaa cgccttgtgc tgaccctagg 1680
agcagccatg gtggagattg ccttgggtgg cgtgatgggc ggcctgtgga agtatctaaa 1740
tgcagtttct ctctgcatcc tgacaataaa tgctgttgct tctaggaaag catcaaatac 1800
catcttgccc ctcatggctc tgttgacacc tgtcactatg gctgaggtga gacttgccgc 1860
aatgttcttt tgtgccatgg ttatcatagg ggtccttcac cagaatttca aggacacctc 1920
catgcagaag actatacctc tggtggccct cacactcaca tcttacctgg gcttgacaca 1980
accttttttg ggcctgtgtg catttctggc aacccgcata tttgggcgaa ggagtatccc 2040
agtgaatgag gcactcgcag cagctggtct agtgggagtg ctggcaggac tggcttttca 2100
ggagatggag aacttccttg gtccgattgc agttggagga ctcctgatga tgctggttag 2160
cgtggctggg agggtggatg ggctagagct caagaagctt ggtgaagttt catgggaaga 2220
ggaggcggag atcagcggga gttccgcccg ctatgatgtg gcactcagtg aacaagggga 2280
gttcaagctg ctttctgaag agaaagtgcc atgggaccag gttgtgatga cctcgctggc 2340
cttggttggg gctgccctcc atccatttgc tcttctgctg gtccttgctg ggtggctgtt 2400
tcatgtcagg ggagctagga gaagtgggga tgtcttgtgg gatattccca ctcctaagat 2460
catcgaggaa tgtgaacatc tggaggatgg gatttatggc atattccagt caaccttctt 2520
gggggcctcc cagcgaggag tgggagtggc acagggaggg gtgttccaca caatgtggca 2580
tgtcacaaga ggagctttcc ttgtcaggaa tggcaagaag ttgattccat cttgggcttc 2640
agtaaaggaa gaccttgtcg cctatggtgg ctcatggaag ttggaaggca gatgggatgg 2700
agaggaagag gtccagttga tcgcggctgt tccaggaaag aacgtggtca acgtccagac 2760
aaaaccgagc ttgttcaaag tgaggaatgg gggagaaatc ggggctgtcg ctcttgacta 2820
tccgagtggc acttcaggat ctcctattgt taacaggaac ggagaggtga ttgggctgta 2880
cggcaatggc atccttgtcg gtgacaactc cttcgtgtcc gccatatccc agactgaggt 2940
gaaggaagaa ggaaaggagg agctccaaga gatcccgaca atgctaaaga aaggaatgac 3000
aactgtcctt gattttcatc ctggagctgg gaagacaaga cgtttcctcc cacagatctt 3060
ggccgagtgc gcacggagac gcttgcgcac tcttgtgttg gcccccacca gggttgttct 3120
ttctgaaatg aaggaggctt ttcacggcct ggacgtgaaa ttccacacac aggctttttc 3180
cgctcacggc agcgggagag aagtcattga tgccatgtgc catgccaccc taacttacag 3240
gatgttggaa ccaactaggg ttgttaactg ggaagtgatc attatggatg aagcccattt 3300
tttggatcca gctagcatag ccgctagagg ttgggcagcg cacagagcta gggcaaatga 3360
aagtgcaaca atcttgatga cagccacacc gcctgggact agtgatgaat ttccacattc 3420
aaatggtgaa atagaagatg ttcaaacgga catacccagt gagccctgga acacagggca 3480
tgactggatc ctggctgaca aaaggcccac ggcatggttc cttccatcca tcagagctgc 3540
aaatgtcatg gctgcctctt tgcgtaaggc tggaaagagt gtggtggtcc tgaacaggaa 3600
aacctttgag agagaatacc ccacgataaa gcagaagaaa cctgacttta tattggccac 3660
tgacatagct gaaatgggag ccaacctttg cgtggagcga gtgctggatt gcaggacggc 3720
ttttaagcct gtgcttgtgg atgaagggag gaaggtggca ataaaagggc cacttcgtat 3780
ctccgcatcc tctgctgctc aaaggagggg gcgcattggg agaaatccca acagagatgg 3840
agactcatac tactattctg agcctacaag tgaaaataat gcccaccacg tctgctggtt 3900
ggaggcctca atgctcttgg acaacatgga ggtgaggggt ggaatggtcg ccccactcta 3960
tggcgttgaa ggaactaaaa caccagtttc ccctggtgaa atgagactga gggatgacca 4020
gaggaaagtc ttcagagaac tagtgaggaa ttgtgacctg cccgtttggc tttcgtggca 4080
agtggccaag gctggtttga agacgaatga tcgtaagtgg tgttttgaag gccctgagga 4140
acatgagatc ttgaatgaca gcggtgaaac agtgaagtgc agggctcctg gaggagcaaa 4200
gaagcctctg cgcccaaggt ggtgtgatga aagggtgtca tctgaccaga gtgcgctgtc 4260
tgaatttatt aagtttgctg aaggtaggag gggagctgct gaagtgctag ttgtgctgag 4320
tgaactccct gatttcctgg ctaaaaaagg tggagaggca atggatacca tcagtgtgtt 4380
cctccactct gaggaaggct ctagggctta ccgcaatgca ctatcaatga tgcctgaggc 4440
aatgacaata gtcatgctgt ttatactggc tggactactg acatcgggaa tggtcatctt 4500
tttcatgtct cccaaaggca tcagtagaat gtctatggcg atgggcacaa tggccggctg 4560
tggatatctc atgttccttg gaggcgtcaa acccactcac atctcctatg tcatgctcat 4620
attctttgtc ctgatggtgg ttgtgatccc cgagccaggg caacaaaggt ccatccaaga 4680
caaccaagtg gcatacctca ttattggcat cctgacgctg gtttcagcgg tggcagccaa 4740
cgagctaggc atgctggaga aaaccaaaga ggacctcttt gggaagaaga acttaattcc 4800
atctagtgct tcaccctgga gttggccgga tcttgacctg aagccaggag ctgcctggac 4860
agtgtacgtt ggcattgtta caatgctctc tccaatgttg caccactgga tcaaagtcga 4920
atatggcaac ctgtctctgt ctggaatagc ccagtcagcc tcagtccttt ctttcatgga 4980
caaggggata ccattcatga agatgaatat ctcggtcata atgctgctgg tcagtggctg 5040
gaattcaata acagtgatgc ctctgctctg tggcataggg tgcgccatgc tccactggtc 5100
tctcatttta cctggaatca aagcgcagca gtcaaagctt gcacagagaa gggtgttcca 5160
tggcgttgcc aagaaccctg tggttgatgg gaatccaaca gttgacattg aggaagctcc 5220
tgaaatgcct gccctttatg agaagaaact ggctctatat ctccttcttg ctctcagcct 5280
agcttctgtt gccatgtgca gaacgccctt ttcattggct gaaggcattg tcctagcatc 5340
agctgcctta gggccgctca tagagggaaa caccagcctt ctttggaatg gacccatggc 5400
tgtctccatg acaggagtca tgagggggaa tcactatgct tttgtgggag tcatgtacaa 5460
tctatggaag atgaaaactg gacgccgggg gagcgcgaat ggaaaaactt tgggtgaagt 5520
ctggaagagg gaactgaatc tgttggacaa gcgacagttt gagttgtata aaaggaccga 5580
cattgtggag gtggatcgtg atacggcacg caggcatttg gccgaaggga aggtggacac 5640
cggggtggcg gtctccaggg ggaccgcaaa gttaaggtgg ttccatgagc gtggctatgt 5700
caagctggaa ggtagggtga ttgacctggg gtgtggccgc ggaggctggt gttactacgc 5760
tgctgcgcaa aaggaagtga gtggggtcaa aggatttact cttggaagag acggccatga 5820
gaaacccatg aatgtgcaaa gtctgggatg gaacatcatc accttcaagg acaaaactga 5880
tatccaccgc ctagaaccag tgaaatgtga cacccttttg tgtgacattg gagagtcatc 5940
atcgtcatcg gtcacagagg gggaaaggac cgtgagagtt cttgatactg tagaaaaatg 6000
gctggcttgt ggggttgaca acttctgtgt gaaggtgtta gctccataca tgccagatgt 6060
tcttgagaaa ctggaattgc tccaaaggag gtttggcgga acagtgatca ggaaccctct 6120
ctccaggaat tccactcatg aaatgtacta cgtgtctgga gcccgcagca atgtcacatt 6180
tactgtgaac caaacatccc gcctcctgat gaggagaatg aggcgtccaa ctggaaaagt 6240
gaccctggag gctgacgtca tcctcccaat tgggacacgc agtgttgaga cagacaaggg 6300
acccctggac aaagaggcca tagaagaaag ggttgagagg ataaaatctg agtacatgac 6360
ctcttggttt tatgacaatg acaaccccta caggacctgg cactactgtg gctcctatgt 6420
cacaaaaacc tcaggaagtg cggcgagcat ggtaaatggt gttattaaaa ttctgacata 6480
tccatgggac aggatagagg aggtcacaag aatggcaatg actgacacaa ccccttttgg 6540
acagcaaaga gtgtttaaag aaaaagttga caccagagca aaggatccac cagcgggaac 6600
taggaagatc atgaaagttg tcaacaggtg gctgttccgc cacctggcca gagaaaagaa 6660
ccccagactg tgcacaaagg aagaatttat tgcaaaagtc cgaagtcatg cagccattgg 6720
agcttacctg gaagaacaag aacagtggaa gactgccaat gaggctgtcc aagacccaaa 6780
gttctgggaa ctggtggatg aagaaaggaa gctgcaccaa caaggcaggt gtcggacttg 6840
tgtgtacaac atgatgggga aaagagagaa gaagctgtca gagtttggga aagcaaaggg 6900
aagccgtgcc atatggtata tgtggctggg agcgcggtat cttgagtttg aggccctggg 6960
attcctgaat gaggaccatt gggcttccag ggaaaactca ggaggaggag tggaaggcat 7020
tggcttacaa tacctaggat atgtgatcag agacctggct gcaatggatg gtggtggatt 7080
ctacgcggat gacaccgctg gatgggacac gcgcatcaca gaggcagacc ttgatgatga 7140
acaggagatc ttgaactaca tgagcccaca tcacaaaaaa ctggcacaag cagtgatgga 7200
aatgacatac aagaacaaag tggtgaaagt gttgagacca gccccaggag ggaaagccta 7260
catggatgtc ataagtcgac gagaccagag aggatccggg caggtagtga cttatgctct 7320
gaacaccatc accaacttga aagtccaatt gatcagaatg gcagaagcag agatggtgat 7380
acatcaccaa catgttcaag attgtgatga atcagttctg accaggctgg aggcatggct 7440
cactgagcac ggatgtgaca gactgaagag gatggcggtg agtggagacg actgtgtggt 7500
ccggcccatc gatgacaggt tcggcctggc cctgtcccat ctcaacgcca tgtccaaggt 7560
tagaaaggac atatctgaat ggcagccatc aaaagggtgg aatgattggg agaatgtgcc 7620
cttctgttcc caccacttcc atgaactaca gctgaaggat ggcaggagga ttgtggtgcc 7680
ttgccgagaa caggacgagc tcattgggag aggaagggtg tctccaggaa acggctggat 7740
gatcaaggaa acagcttgcc tcagcaaagc ctatgccaac atgtggtcac tgatgtattt 7800
tcacaaaagg gacatgaggc tactgtcatt ggctgtttcc tcagctgttc ccacctcatg 7860
ggttccacaa ggacgcacaa catggtcgat tcatgggaaa ggggagtgga tgaccacgga 7920
agacatgctt gaggtgtgga acagagtatg gataaccaac aacccacaca tgcaggacaa 7980
gacaatggtg aaaaaatgga gagatgtccc ttatctaacc aagagacaag acaagctgtg 8040
cggatcactg attggaatga ccaatagggc cacctgggcc tcccacatcc atttagtcat 8100
ccatcgtatc cgaacgctga ttggacagga gaaatacact gactacctaa cagtcatgga 8160
caggtattct gtggatgctg acctgcaact gggtgagctt atctgaaaca ccatctaaca 8220
ggaataaccg ggatacaaac cacgggtgga gaaccggact ccccacaacc tgaaaccggg 8280
atataaacca cggctggaga accggactcc gcacttaaaa tgaaacagaa accgggataa 8340
aaactacgga tggagaaccg gactccacac attgagacag aagaagttgt cagcccagaa 8400
ccccacacga gttttgccac tgctaagctg tgaggcagtg caggctggga cagccgacct 8460
ccaggttgcg aaaaacctgg tttctgggac ctcccacccc agagtaaaaa gaacggagcc 8520
tccgctacca ccctcccacg tggtggtaga aagacggggt ctagaggtta gaggagaccc 8580
tccagggaac aaatagtggg accatattga cgccagggaa agaccggagt ggttctctgc 8640
ttttcctcca gaggtctgtg agcacagttt gctcaagaat aagcagacct ttggatgaca 8700
aacacaaaac cactcgag 8718
<210> 102
<211> 8358
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 102
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat ggccactgac acatacgatt ggaacatcag ttgaagagag 660
tgaaatgttc atgccgagat caatcggagg cccagttagc tctcacaatc atatccctgg 720
atacaaggtt cagacgaacg gaccttggat gcaggtacca ctagaagtga agagagaagc 780
ttgcccaggg actagcgtga tcattgatgg caactgtgat ggacggggaa aatcaaccag 840
atccaccacg gatagcggga aagttattcc tgaatggtgt tgccgctcct gcacaatgcc 900
gcctgtgagc ttccatggta gtgatgggtg ttggtatccc atggaaatta ggccaaggaa 960
aacgcatgaa agccatctgg tgcgctcctg ggttacagct ggagaaatac atgctgtccc 1020
ttttggtttg gtgagcatga tgatagcaat ggaagtggtc ctaaggaaaa gacagggacc 1080
aaagcaaatg ttggttggag gagtagtgct cttgggagca atgctggtcg ggcaagtaac 1140
tctccttgat ttgctgaaac tcacagtggc tgtgggattg catttccatg agatgaacaa 1200
tggaggagac gccatgtata tggcgttgat tgctgccttt tcaatcagac cagggctgct 1260
catcggcttt gggctcagga ccctatggag ccctcgggaa cgccttgtgc tgaccctagg 1320
agcagccatg gtggagattg ccttgggtgg cgtgatgggc ggcctgtgga agtatctaaa 1380
tgcagtttct ctctgcatcc tgacaataaa tgctgttgct tctaggaaag catcaaatac 1440
catcttgccc ctcatggctc tgttgacacc tgtcactatg gctgaggtga gacttgccgc 1500
aatgttcttt tgtgccatgg ttatcatagg ggtccttcac cagaatttca aggacacctc 1560
catgcagaag actatacctc tggtggccct cacactcaca tcttacctgg gcttgacaca 1620
accttttttg ggcctgtgtg catttctggc aacccgcata tttgggcgaa ggagtatccc 1680
agtgaatgag gcactcgcag cagctggtct agtgggagtg ctggcaggac tggcttttca 1740
ggagatggag aacttccttg gtccgattgc agttggagga ctcctgatga tgctggttag 1800
cgtggctggg agggtggatg ggctagagct caagaagctt ggtgaagttt catgggaaga 1860
ggaggcggag atcagcggga gttccgcccg ctatgatgtg gcactcagtg aacaagggga 1920
gttcaagctg ctttctgaag agaaagtgcc atgggaccag gttgtgatga cctcgctggc 1980
cttggttggg gctgccctcc atccatttgc tcttctgctg gtccttgctg ggtggctgtt 2040
tcatgtcagg ggagctagga gaagtgggga tgtcttgtgg gatattccca ctcctaagat 2100
catcgaggaa tgtgaacatc tggaggatgg gatttatggc atattccagt caaccttctt 2160
gggggcctcc cagcgaggag tgggagtggc acagggaggg gtgttccaca caatgtggca 2220
tgtcacaaga ggagctttcc ttgtcaggaa tggcaagaag ttgattccat cttgggcttc 2280
agtaaaggaa gaccttgtcg cctatggtgg ctcatggaag ttggaaggca gatgggatgg 2340
agaggaagag gtccagttga tcgcggctgt tccaggaaag aacgtggtca acgtccagac 2400
aaaaccgagc ttgttcaaag tgaggaatgg gggagaaatc ggggctgtcg ctcttgacta 2460
tccgagtggc acttcaggat ctcctattgt taacaggaac ggagaggtga ttgggctgta 2520
cggcaatggc atccttgtcg gtgacaactc cttcgtgtcc gccatatccc agactgaggt 2580
gaaggaagaa ggaaaggagg agctccaaga gatcccgaca atgctaaaga aaggaatgac 2640
aactgtcctt gattttcatc ctggagctgg gaagacaaga cgtttcctcc cacagatctt 2700
ggccgagtgc gcacggagac gcttgcgcac tcttgtgttg gcccccacca gggttgttct 2760
ttctgaaatg aaggaggctt ttcacggcct ggacgtgaaa ttccacacac aggctttttc 2820
cgctcacggc agcgggagag aagtcattga tgccatgtgc catgccaccc taacttacag 2880
gatgttggaa ccaactaggg ttgttaactg ggaagtgatc attatggatg aagcccattt 2940
tttggatcca gctagcatag ccgctagagg ttgggcagcg cacagagcta gggcaaatga 3000
aagtgcaaca atcttgatga cagccacacc gcctgggact agtgatgaat ttccacattc 3060
aaatggtgaa atagaagatg ttcaaacgga catacccagt gagccctgga acacagggca 3120
tgactggatc ctggctgaca aaaggcccac ggcatggttc cttccatcca tcagagctgc 3180
aaatgtcatg gctgcctctt tgcgtaaggc tggaaagagt gtggtggtcc tgaacaggaa 3240
aacctttgag agagaatacc ccacgataaa gcagaagaaa cctgacttta tattggccac 3300
tgacatagct gaaatgggag ccaacctttg cgtggagcga gtgctggatt gcaggacggc 3360
ttttaagcct gtgcttgtgg atgaagggag gaaggtggca ataaaagggc cacttcgtat 3420
ctccgcatcc tctgctgctc aaaggagggg gcgcattggg agaaatccca acagagatgg 3480
agactcatac tactattctg agcctacaag tgaaaataat gcccaccacg tctgctggtt 3540
ggaggcctca atgctcttgg acaacatgga ggtgaggggt ggaatggtcg ccccactcta 3600
tggcgttgaa ggaactaaaa caccagtttc ccctggtgaa atgagactga gggatgacca 3660
gaggaaagtc ttcagagaac tagtgaggaa ttgtgacctg cccgtttggc tttcgtggca 3720
agtggccaag gctggtttga agacgaatga tcgtaagtgg tgttttgaag gccctgagga 3780
acatgagatc ttgaatgaca gcggtgaaac agtgaagtgc agggctcctg gaggagcaaa 3840
gaagcctctg cgcccaaggt ggtgtgatga aagggtgtca tctgaccaga gtgcgctgtc 3900
tgaatttatt aagtttgctg aaggtaggag gggagctgct gaagtgctag ttgtgctgag 3960
tgaactccct gatttcctgg ctaaaaaagg tggagaggca atggatacca tcagtgtgtt 4020
cctccactct gaggaaggct ctagggctta ccgcaatgca ctatcaatga tgcctgaggc 4080
aatgacaata gtcatgctgt ttatactggc tggactactg acatcgggaa tggtcatctt 4140
tttcatgtct cccaaaggca tcagtagaat gtctatggcg atgggcacaa tggccggctg 4200
tggatatctc atgttccttg gaggcgtcaa acccactcac atctcctatg tcatgctcat 4260
attctttgtc ctgatggtgg ttgtgatccc cgagccaggg caacaaaggt ccatccaaga 4320
caaccaagtg gcatacctca ttattggcat cctgacgctg gtttcagcgg tggcagccaa 4380
cgagctaggc atgctggaga aaaccaaaga ggacctcttt gggaagaaga acttaattcc 4440
atctagtgct tcaccctgga gttggccgga tcttgacctg aagccaggag ctgcctggac 4500
agtgtacgtt ggcattgtta caatgctctc tccaatgttg caccactgga tcaaagtcga 4560
atatggcaac ctgtctctgt ctggaatagc ccagtcagcc tcagtccttt ctttcatgga 4620
caaggggata ccattcatga agatgaatat ctcggtcata atgctgctgg tcagtggctg 4680
gaattcaata acagtgatgc ctctgctctg tggcataggg tgcgccatgc tccactggtc 4740
tctcatttta cctggaatca aagcgcagca gtcaaagctt gcacagagaa gggtgttcca 4800
tggcgttgcc aagaaccctg tggttgatgg gaatccaaca gttgacattg aggaagctcc 4860
tgaaatgcct gccctttatg agaagaaact ggctctatat ctccttcttg ctctcagcct 4920
agcttctgtt gccatgtgca gaacgccctt ttcattggct gaaggcattg tcctagcatc 4980
agctgcctta gggccgctca tagagggaaa caccagcctt ctttggaatg gacccatggc 5040
tgtctccatg acaggagtca tgagggggaa tcactatgct tttgtgggag tcatgtacaa 5100
tctatggaag atgaaaactg gacgccgggg gagcgcgaat ggaaaaactt tgggtgaagt 5160
ctggaagagg gaactgaatc tgttggacaa gcgacagttt gagttgtata aaaggaccga 5220
cattgtggag gtggatcgtg atacggcacg caggcatttg gccgaaggga aggtggacac 5280
cggggtggcg gtctccaggg ggaccgcaaa gttaaggtgg ttccatgagc gtggctatgt 5340
caagctggaa ggtagggtga ttgacctggg gtgtggccgc ggaggctggt gttactacgc 5400
tgctgcgcaa aaggaagtga gtggggtcaa aggatttact cttggaagag acggccatga 5460
gaaacccatg aatgtgcaaa gtctgggatg gaacatcatc accttcaagg acaaaactga 5520
tatccaccgc ctagaaccag tgaaatgtga cacccttttg tgtgacattg gagagtcatc 5580
atcgtcatcg gtcacagagg gggaaaggac cgtgagagtt cttgatactg tagaaaaatg 5640
gctggcttgt ggggttgaca acttctgtgt gaaggtgtta gctccataca tgccagatgt 5700
tcttgagaaa ctggaattgc tccaaaggag gtttggcgga acagtgatca ggaaccctct 5760
ctccaggaat tccactcatg aaatgtacta cgtgtctgga gcccgcagca atgtcacatt 5820
tactgtgaac caaacatccc gcctcctgat gaggagaatg aggcgtccaa ctggaaaagt 5880
gaccctggag gctgacgtca tcctcccaat tgggacacgc agtgttgaga cagacaaggg 5940
acccctggac aaagaggcca tagaagaaag ggttgagagg ataaaatctg agtacatgac 6000
ctcttggttt tatgacaatg acaaccccta caggacctgg cactactgtg gctcctatgt 6060
cacaaaaacc tcaggaagtg cggcgagcat ggtaaatggt gttattaaaa ttctgacata 6120
tccatgggac aggatagagg aggtcacaag aatggcaatg actgacacaa ccccttttgg 6180
acagcaaaga gtgtttaaag aaaaagttga caccagagca aaggatccac cagcgggaac 6240
taggaagatc atgaaagttg tcaacaggtg gctgttccgc cacctggcca gagaaaagaa 6300
ccccagactg tgcacaaagg aagaatttat tgcaaaagtc cgaagtcatg cagccattgg 6360
agcttacctg gaagaacaag aacagtggaa gactgccaat gaggctgtcc aagacccaaa 6420
gttctgggaa ctggtggatg aagaaaggaa gctgcaccaa caaggcaggt gtcggacttg 6480
tgtgtacaac atgatgggga aaagagagaa gaagctgtca gagtttggga aagcaaaggg 6540
aagccgtgcc atatggtata tgtggctggg agcgcggtat cttgagtttg aggccctggg 6600
attcctgaat gaggaccatt gggcttccag ggaaaactca ggaggaggag tggaaggcat 6660
tggcttacaa tacctaggat atgtgatcag agacctggct gcaatggatg gtggtggatt 6720
ctacgcggat gacaccgctg gatgggacac gcgcatcaca gaggcagacc ttgatgatga 6780
acaggagatc ttgaactaca tgagcccaca tcacaaaaaa ctggcacaag cagtgatgga 6840
aatgacatac aagaacaaag tggtgaaagt gttgagacca gccccaggag ggaaagccta 6900
catggatgtc ataagtcgac gagaccagag aggatccggg caggtagtga cttatgctct 6960
gaacaccatc accaacttga aagtccaatt gatcagaatg gcagaagcag agatggtgat 7020
acatcaccaa catgttcaag attgtgatga atcagttctg accaggctgg aggcatggct 7080
cactgagcac ggatgtgaca gactgaagag gatggcggtg agtggagacg actgtgtggt 7140
ccggcccatc gatgacaggt tcggcctggc cctgtcccat ctcaacgcca tgtccaaggt 7200
tagaaaggac atatctgaat ggcagccatc aaaagggtgg aatgattggg agaatgtgcc 7260
cttctgttcc caccacttcc atgaactaca gctgaaggat ggcaggagga ttgtggtgcc 7320
ttgccgagaa caggacgagc tcattgggag aggaagggtg tctccaggaa acggctggat 7380
gatcaaggaa acagcttgcc tcagcaaagc ctatgccaac atgtggtcac tgatgtattt 7440
tcacaaaagg gacatgaggc tactgtcatt ggctgtttcc tcagctgttc ccacctcatg 7500
ggttccacaa ggacgcacaa catggtcgat tcatgggaaa ggggagtgga tgaccacgga 7560
agacatgctt gaggtgtgga acagagtatg gataaccaac aacccacaca tgcaggacaa 7620
gacaatggtg aaaaaatgga gagatgtccc ttatctaacc aagagacaag acaagctgtg 7680
cggatcactg attggaatga ccaatagggc cacctgggcc tcccacatcc atttagtcat 7740
ccatcgtatc cgaacgctga ttggacagga gaaatacact gactacctaa cagtcatgga 7800
caggtattct gtggatgctg acctgcaact gggtgagctt atctgaaaca ccatctaaca 7860
ggaataaccg ggatacaaac cacgggtgga gaaccggact ccccacaacc tgaaaccggg 7920
atataaacca cggctggaga accggactcc gcacttaaaa tgaaacagaa accgggataa 7980
aaactacgga tggagaaccg gactccacac attgagacag aagaagttgt cagcccagaa 8040
ccccacacga gttttgccac tgctaagctg tgaggcagtg caggctggga cagccgacct 8100
ccaggttgcg aaaaacctgg tttctgggac ctcccacccc agagtaaaaa gaacggagcc 8160
tccgctacca ccctcccacg tggtggtaga aagacggggt ctagaggtta gaggagaccc 8220
tccagggaac aaatagtggg accatattga cgccagggaa agaccggagt ggttctctgc 8280
ttttcctcca gaggtctgtg agcacagttt gctcaagaat aagcagacct ttggatgaca 8340
aacacaaaac cactcgag 8358
<210> 103
<211> 9132
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 103
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggag ttggggcgga 720
tcaaggatgc gccatcaact ttggcaagag agagctcaag tgcggagatg gtatcttcat 780
atttagagac tctgatgact ggctgaacaa gtactcatac tatccagaag atcctgtgaa 840
gcttgcatca atagtgaaag cctcttttga agaagggaag tgtggcctaa attcagttga 900
ctcccttgag catgagatgt ggagaagcag ggcagatgag atcaatgcca tttttgagga 960
aaacgaggtg gacatttctg ttgtcgtgca ggatccaaag aatgtttacc agagaggaac 1020
tcatccattt tccagaattc gggatggtct gcagtatggt tggaagactt ggggtaagaa 1080
ccttgtgttc tccccaggga ggaagaatgg aagcttcatc atagatggaa agtccaggaa 1140
agaatgcccg ttttcaaacc gggtctggaa ttctttccag atagaggagt ttgggacggg 1200
agtgttcacc acacgcgtgt acatggacgc agtctttgaa tacaccatag actgcgatgg 1260
atctatcttg ggtgcagcgg tgaacggaaa aaagagtgcc catggctctc caacattttg 1320
gatgggaagt catgaagtaa atgggacatg gatgatccac accttggagg cattagatta 1380
caaggagtgt gagtggccac tgacacatac gattggaaca tcagttgaag agagtgaaat 1440
gttcatgccg agatcaatcg gaggcccagt tagctctcac aatcatatcc ctggatacaa 1500
ggttcagacg aacggacctt ggatgcaggt accactagaa gtgaagagag aagcttgccc 1560
agggactagc gtgatcattg atggcaactg tgatggacgg ggaaaatcaa ccagatccac 1620
cacggatagc gggaaagtta ttcctgaatg gtgttgccgc tcctgcacaa tgccgcctgt 1680
gagcttccat ggtagtgatg ggtgttggta tcccatggaa attaggccaa ggaaaacgca 1740
tgaaagccat ctggtgcgct cctgggttac agctggagaa atacatgctg tcccttttgg 1800
tttggtgagc atgatgatag caatggaagt ggtcctaagg aaaagacagg gaccaaagca 1860
aatgttggtt ggaggagtag tgctcttggg agcaatgctg gtcgggcaag taactctcct 1920
tgatttgctg aaactcacag tggctgtggg attgcatttc catgagatga acaatggagg 1980
agacgccatg tatatggcgt tgattgctgc cttttcaatc agaccagggc tgctcatcgg 2040
ctttgggctc aggaccctat ggagccctcg ggaacgcctt gtgctgaccc taggagcagc 2100
catggtggag attgccttgg gtggcgtgat gggcggcctg tggaagtatc taaatgcagt 2160
ttctctctgc atcctgacaa taaatgctgt tgcttctagg aaagcatcaa ataccatctt 2220
gcccctcatg gctctgttga cacctgtcac tatggctgag gtgagacttg ccgcaatgtt 2280
cttttgtgcc atggttatca taggggtcct tcaccagaat ttcaaggaca cctccatgca 2340
gaagactata cctctggtgg ccctcacact cacatcttac ctgggcttga cacaaccttt 2400
tttgggcctg tgtgcatttc tggcaacccg catatttggg cgaaggagta tcccagtgaa 2460
tgaggcactc gcagcagctg gtctagtggg agtgctggca ggactggctt ttcaggagat 2520
ggagaacttc cttggtccga ttgcagttgg aggactcctg atgatgctgg ttagcgtggc 2580
tgggagggtg gatgggctag agctcaagaa gcttggtgaa gtttcatggg aagaggaggc 2640
ggagatcagc gggagttccg cccgctatga tgtggcactc agtgaacaag gggagttcaa 2700
gctgctttct gaagagaaag tgccatggga ccaggttgtg atgacctcgc tggccttggt 2760
tggggctgcc ctccatccat ttgctcttct gctggtcctt gctgggtggc tgtttcatgt 2820
caggggagct aggagaagtg gggatgtctt gtgggatatt cccactccta agatcatcga 2880
ggaatgtgaa catctggagg atgggattta tggcatattc cagtcaacct tcttgggggc 2940
ctcccagcga ggagtgggag tggcacaggg aggggtgttc cacacaatgt ggcatgtcac 3000
aagaggagct ttccttgtca ggaatggcaa gaagttgatt ccatcttggg cttcagtaaa 3060
ggaagacctt gtcgcctatg gtggctcatg gaagttggaa ggcagatggg atggagagga 3120
agaggtccag ttgatcgcgg ctgttccagg aaagaacgtg gtcaacgtcc agacaaaacc 3180
gagcttgttc aaagtgagga atgggggaga aatcggggct gtcgctcttg actatccgag 3240
tggcacttca ggatctccta ttgttaacag gaacggagag gtgattgggc tgtacggcaa 3300
tggcatcctt gtcggtgaca actccttcgt gtccgccata tcccagactg aggtgaagga 3360
agaaggaaag gaggagctcc aagagatccc gacaatgcta aagaaaggaa tgacaactgt 3420
ccttgatttt catcctggag ctgggaagac aagacgtttc ctcccacaga tcttggccga 3480
gtgcgcacgg agacgcttgc gcactcttgt gttggccccc accagggttg ttctttctga 3540
aatgaaggag gcttttcacg gcctggacgt gaaattccac acacaggctt tttccgctca 3600
cggcagcggg agagaagtca ttgatgccat gtgccatgcc accctaactt acaggatgtt 3660
ggaaccaact agggttgtta actgggaagt gatcattatg gatgaagccc attttttgga 3720
tccagctagc atagccgcta gaggttgggc agcgcacaga gctagggcaa atgaaagtgc 3780
aacaatcttg atgacagcca caccgcctgg gactagtgat gaatttccac attcaaatgg 3840
tgaaatagaa gatgttcaaa cggacatacc cagtgagccc tggaacacag ggcatgactg 3900
gatcctggct gacaaaaggc ccacggcatg gttccttcca tccatcagag ctgcaaatgt 3960
catggctgcc tctttgcgta aggctggaaa gagtgtggtg gtcctgaaca ggaaaacctt 4020
tgagagagaa taccccacga taaagcagaa gaaacctgac tttatattgg ccactgacat 4080
agctgaaatg ggagccaacc tttgcgtgga gcgagtgctg gattgcagga cggcttttaa 4140
gcctgtgctt gtggatgaag ggaggaaggt ggcaataaaa gggccacttc gtatctccgc 4200
atcctctgct gctcaaagga gggggcgcat tgggagaaat cccaacagag atggagactc 4260
atactactat tctgagccta caagtgaaaa taatgcccac cacgtctgct ggttggaggc 4320
ctcaatgctc ttggacaaca tggaggtgag gggtggaatg gtcgccccac tctatggcgt 4380
tgaaggaact aaaacaccag tttcccctgg tgaaatgaga ctgagggatg accagaggaa 4440
agtcttcaga gaactagtga ggaattgtga cctgcccgtt tggctttcgt ggcaagtggc 4500
caaggctggt ttgaagacga atgatcgtaa gtggtgtttt gaaggccctg aggaacatga 4560
gatcttgaat gacagcggtg aaacagtgaa gtgcagggct cctggaggag caaagaagcc 4620
tctgcgccca aggtggtgtg atgaaagggt gtcatctgac cagagtgcgc tgtctgaatt 4680
tattaagttt gctgaaggta ggaggggagc tgctgaagtg ctagttgtgc tgagtgaact 4740
ccctgatttc ctggctaaaa aaggtggaga ggcaatggat accatcagtg tgttcctcca 4800
ctctgaggaa ggctctaggg cttaccgcaa tgcactatca atgatgcctg aggcaatgac 4860
aatagtcatg ctgtttatac tggctggact actgacatcg ggaatggtca tctttttcat 4920
gtctcccaaa ggcatcagta gaatgtctat ggcgatgggc acaatggccg gctgtggata 4980
tctcatgttc cttggaggcg tcaaacccac tcacatctcc tatgtcatgc tcatattctt 5040
tgtcctgatg gtggttgtga tccccgagcc agggcaacaa aggtccatcc aagacaacca 5100
agtggcatac ctcattattg gcatcctgac gctggtttca gcggtggcag ccaacgagct 5160
aggcatgctg gagaaaacca aagaggacct ctttgggaag aagaacttaa ttccatctag 5220
tgcttcaccc tggagttggc cggatcttga cctgaagcca ggagctgcct ggacagtgta 5280
cgttggcatt gttacaatgc tctctccaat gttgcaccac tggatcaaag tcgaatatgg 5340
caacctgtct ctgtctggaa tagcccagtc agcctcagtc ctttctttca tggacaaggg 5400
gataccattc atgaagatga atatctcggt cataatgctg ctggtcagtg gctggaattc 5460
aataacagtg atgcctctgc tctgtggcat agggtgcgcc atgctccact ggtctctcat 5520
tttacctgga atcaaagcgc agcagtcaaa gcttgcacag agaagggtgt tccatggcgt 5580
tgccaagaac cctgtggttg atgggaatcc aacagttgac attgaggaag ctcctgaaat 5640
gcctgccctt tatgagaaga aactggctct atatctcctt cttgctctca gcctagcttc 5700
tgttgccatg tgcagaacgc ccttttcatt ggctgaaggc attgtcctag catcagctgc 5760
cttagggccg ctcatagagg gaaacaccag ccttctttgg aatggaccca tggctgtctc 5820
catgacagga gtcatgaggg ggaatcacta tgcttttgtg ggagtcatgt acaatctatg 5880
gaagatgaaa actggacgcc gggggagcgc gaatggaaaa actttgggtg aagtctggaa 5940
gagggaactg aatctgttgg acaagcgaca gtttgagttg tataaaagga ccgacattgt 6000
ggaggtggat cgtgatacgg cacgcaggca tttggccgaa gggaaggtgg acaccggggt 6060
ggcggtctcc agggggaccg caaagttaag gtggttccat gagcgtggct atgtcaagct 6120
ggaaggtagg gtgattgacc tggggtgtgg ccgcggaggc tggtgttact acgctgctgc 6180
gcaaaaggaa gtgagtgggg tcaaaggatt tactcttgga agagacggcc atgagaaacc 6240
catgaatgtg caaagtctgg gatggaacat catcaccttc aaggacaaaa ctgatatcca 6300
ccgcctagaa ccagtgaaat gtgacaccct tttgtgtgac attggagagt catcatcgtc 6360
atcggtcaca gagggggaaa ggaccgtgag agttcttgat actgtagaaa aatggctggc 6420
ttgtggggtt gacaacttct gtgtgaaggt gttagctcca tacatgccag atgttcttga 6480
gaaactggaa ttgctccaaa ggaggtttgg cggaacagtg atcaggaacc ctctctccag 6540
gaattccact catgaaatgt actacgtgtc tggagcccgc agcaatgtca catttactgt 6600
gaaccaaaca tcccgcctcc tgatgaggag aatgaggcgt ccaactggaa aagtgaccct 6660
ggaggctgac gtcatcctcc caattgggac acgcagtgtt gagacagaca agggacccct 6720
ggacaaagag gccatagaag aaagggttga gaggataaaa tctgagtaca tgacctcttg 6780
gttttatgac aatgacaacc cctacaggac ctggcactac tgtggctcct atgtcacaaa 6840
aacctcagga agtgcggcga gcatggtaaa tggtgttatt aaaattctga catatccatg 6900
ggacaggata gaggaggtca caagaatggc aatgactgac acaacccctt ttggacagca 6960
aagagtgttt aaagaaaaag ttgacaccag agcaaaggat ccaccagcgg gaactaggaa 7020
gatcatgaaa gttgtcaaca ggtggctgtt ccgccacctg gccagagaaa agaaccccag 7080
actgtgcaca aaggaagaat ttattgcaaa agtccgaagt catgcagcca ttggagctta 7140
cctggaagaa caagaacagt ggaagactgc caatgaggct gtccaagacc caaagttctg 7200
ggaactggtg gatgaagaaa ggaagctgca ccaacaaggc aggtgtcgga cttgtgtgta 7260
caacatgatg gggaaaagag agaagaagct gtcagagttt gggaaagcaa agggaagccg 7320
tgccatatgg tatatgtggc tgggagcgcg gtatcttgag tttgaggccc tgggattcct 7380
gaatgaggac cattgggctt ccagggaaaa ctcaggagga ggagtggaag gcattggctt 7440
acaataccta ggatatgtga tcagagacct ggctgcaatg gatggtggtg gattctacgc 7500
ggatgacacc gctggatggg acacgcgcat cacagaggca gaccttgatg atgaacagga 7560
gatcttgaac tacatgagcc cacatcacaa aaaactggca caagcagtga tggaaatgac 7620
atacaagaac aaagtggtga aagtgttgag accagcccca ggagggaaag cctacatgga 7680
tgtcataagt cgacgagacc agagaggatc cgggcaggta gtgacttatg ctctgaacac 7740
catcaccaac ttgaaagtcc aattgatcag aatggcagaa gcagagatgg tgatacatca 7800
ccaacatgtt caagattgtg atgaatcagt tctgaccagg ctggaggcat ggctcactga 7860
gcacggatgt gacagactga agaggatggc ggtgagtgga gacgactgtg tggtccggcc 7920
catcgatgac aggttcggcc tggccctgtc ccatctcaac gccatgtcca aggttagaaa 7980
ggacatatct gaatggcagc catcaaaagg gtggaatgat tgggagaatg tgcccttctg 8040
ttcccaccac ttccatgaac tacagctgaa ggatggcagg aggattgtgg tgccttgccg 8100
agaacaggac gagctcattg ggagaggaag ggtgtctcca ggaaacggct ggatgatcaa 8160
ggaaacagct tgcctcagca aagcctatgc caacatgtgg tcactgatgt attttcacaa 8220
aagggacatg aggctactgt cattggctgt ttcctcagct gttcccacct catgggttcc 8280
acaaggacgc acaacatggt cgattcatgg gaaaggggag tggatgacca cggaagacat 8340
gcttgaggtg tggaacagag tatggataac caacaaccca cacatgcagg acaagacaat 8400
ggtgaaaaaa tggagagatg tcccttatct aaccaagaga caagacaagc tgtgcggatc 8460
actgattgga atgaccaata gggccacctg ggcctcccac atccatttag tcatccatcg 8520
tatccgaacg ctgattggac aggagaaata cactgactac ctaacagtca tggacaggta 8580
ttctgtggat gctgacctgc aactgggtga gcttatctga aacaccatct aacaggaata 8640
accgggatac aaaccacggg tggagaaccg gactccccac aacctgaaac cgggatataa 8700
accacggctg gagaaccgga ctccgcactt aaaatgaaac agaaaccggg ataaaaacta 8760
cggatggaga accggactcc acacattgag acagaagaag ttgtcagccc agaaccccac 8820
acgagttttg ccactgctaa gctgtgaggc agtgcaggct gggacagccg acctccaggt 8880
tgcgaaaaac ctggtttctg ggacctccca ccccagagta aaaagaacgg agcctccgct 8940
accaccctcc cacgtggtgg tagaaagacg gggtctagag gttagaggag accctccagg 9000
gaacaaatag tgggaccata ttgacgccag ggaaagaccg gagtggttct ctgcttttcc 9060
tccagaggtc tgtgagcaca gtttgctcaa gaataagcag acctttggat gacaaacaca 9120
aaaccactcg ag 9132
<210> 104
<211> 10770
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 104
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggttcgtga ggaacccctt ttttgcagtg acggctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatagac ctgctgaggt 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa agctggatag tggacagaca 1500
gtgggcccag gacttgaccc tgccatggca gagtggaagt ggcggggtgt ggagagagat 1560
gcatcatctt gtcgaatttg aacctccgca tgccgccact atcagagtac tggccctggg 1620
aaaccaggaa ggctccttga aaacagctct tactggcgca atgagggtta caaaggacac 1680
aaatgacaac aacctttaca aactacatgg tggacatgtt tcttgcagag tgaaattgtc 1740
agctttgaca ctcaagggga catcctacaa aatatgcact gacaaaatgt tttttgtcaa 1800
gaacccaact gacactggcc atggcactgt tgtgatgcag gtgaaagtgt caaaaggagc 1860
cccctgcagg attccagtga tagtagctga tgatcttaca gcggcaatca ataaaggcat 1920
tttggttaca gttaacccca tcgcctcaac caatgatgat gaagtgctga ttgaggtgaa 1980
cccacctttt ggagacagct acattatcgt tgggagagga gattcacgtc tcacttacca 2040
gtggcacaaa gagggaagct caataggaaa gttgttcact cagaccatga aaggcgtgga 2100
acgcctggcc gtcatgggag acaccgcctg ggatttcagc tccgctggag ggttcttcac 2160
ttcggttggg aaaggaattc atacggtgtt tggctctgcc tttcaggggc tatttggcgg 2220
cttgaactgg ataacaaagg tcatcatggg ggcggtactt atatgggttg gcatcaacac 2280
aagaaacatg acaatgtcca tgagcatgat cttggtagga gtgatcatga tgtttttgtc 2340
tctaggagtt ggggcggatc aaggatgcgc catcaacttt ggcaagagag agctcaagtg 2400
cggagatggt atcttcatat ttagagactc tgatgactgg ctgaacaagt actcatacta 2460
tccagaagat cctgtgaagc ttgcatcaat agtgaaagcc tcttttgaag aagggaagtg 2520
tggcctaaat tcagttgact cccttgagca tgagatgtgg agaagcaggg cagatgagat 2580
caatgccatt tttgaggaaa acgaggtgga catttctgtt gtcgtgcagg atccaaagaa 2640
tgtttaccag agaggaactc atccattttc cagaattcgg gatggtctgc agtatggttg 2700
gaagacttgg ggtaagaacc ttgtgttctc cccagggagg aagaatggaa gcttcatcat 2760
agatggaaag tccaggaaag aatgcccgtt ttcaaaccgg gtctggaatt ctttccagat 2820
agaggagttt gggacgggag tgttcaccac acgcgtgtac atggacgcag tctttgaata 2880
caccatagac tgcgatggat ctatcttggg tgcagcggtg aacggaaaaa agagtgccca 2940
tggctctcca acattttgga tgggaagtca tgaagtaaat gggacatgga tgatccacac 3000
cttggaggca ttagattaca aggagtgtga gtggccactg acacatacga ttggaacatc 3060
agttgaagag agtgaaatgt tcatgccgag atcaatcgga ggcccagtta gctctcacaa 3120
tcatatccct ggatacaagg ttcagacgaa cggaccttgg atgcaggtac cactagaagt 3180
gaagagagaa gcttgcccag ggactagcgt gatcattgat ggcaactgtg atggacgggg 3240
aaaatcaacc agatccacca cggatagcgg gaaagttatt cctgaatggt gttgccgctc 3300
ctgcacaatg ccgcctgtga gcttccatgg tagtgatggg tgttggtatc ccatggaaat 3360
taggccaagg aaaacgcatg aaagccatct ggtgcgctcc tgggttacag ctggagaaat 3420
acatgctgtc ccttttggtt tggtgagcat gatgatagca atggaagtgg tcctaaggaa 3480
aagacaggga ccaaagcaaa tgttggttgg aggagtagtg ctcttgggag caatgctggt 3540
cgggcaagta actctccttg atttgctgaa actcacagtg gctgtgggat tgcatttcca 3600
tgagatgaac aatggaggag acgccatgta tatggcgttg attgctgcct tttcaatcag 3660
accagggctg ctcatcggct ttgggctcag gaccctatgg agccctcggg aacgccttgt 3720
gctgacccta ggagcagcca tggtggagat tgccttgggt ggcgtgatgg gcggcctgtg 3780
gaagtatcta aatgcagttt ctctctgcat cctgacaata aatgctgttg cttctaggaa 3840
agcatcaaat accatcttgc ccctcatggc tctgttgaca cctgtcacta tggctgaggt 3900
gagacttgcc gcaatgttct tttgtgccat ggttatcata ggggtccttc accagaattt 3960
caaggacacc tccatgcaga agactatacc tctggtggcc ctcacactca catcttacct 4020
gggcttgaca caaccttttt tgggcctgtg tgcatttctg gcaacccgca tatttgggcg 4080
aaggagtatc ccagtgaatg aggcactcgc agcagctggt ctagtgggag tgctggcagg 4140
actggctttt caggagatgg agaacttcct tggtccgatt gcagttggag gactcctgat 4200
gatgctggtt agcgtggctg ggagggtgga tgggctagag ctcaagaagc ttggtgaagt 4260
ttcatgggaa gaggaggcgg agatcagcgg gagttccgcc cgctatgatg tggcactcag 4320
tgaacaaggg gagttcaagc tgctttctga agagaaagtg ccatgggacc aggttgtgat 4380
gacctcgctg gccttggttg gggctgccct ccatccattt gctcttctgc tggtccttgc 4440
tgggtggctg tttcatgtca ggggagctag gagaagtggg gatgtcttgt gggatattcc 4500
cactcctaag atcatcgagg aatgtgaaca tctggaggat gggatttatg gcatattcca 4560
gtcaaccttc ttgggggcct cccagcgagg agtgggagtg gcacagggag gggtgttcca 4620
cacaatgtgg catgtcacaa gaggagcttt ccttgtcagg aatggcaaga agttgattcc 4680
atcttgggct tcagtaaagg aagaccttgt cgcctatggt ggctcatgga agttggaagg 4740
cagatgggat ggagaggaag aggtccagtt gatcgcggct gttccaggaa agaacgtggt 4800
caacgtccag acaaaaccga gcttgttcaa agtgaggaat gggggagaaa tcggggctgt 4860
cgctcttgac tatccgagtg gcacttcagg atctcctatt gttaacagga acggagaggt 4920
gattgggctg tacggcaatg gcatccttgt cggtgacaac tccttcgtgt ccgccatatc 4980
ccagactgag gtgaaggaag aaggaaagga ggagctccaa gagatcccga caatgctaaa 5040
gaaaggaatg acaactgtcc ttgattttca tcctggagct gggaagacaa gacgtttcct 5100
cccacagatc ttggccgagt gcgcacggag acgcttgcgc actcttgtgt tggcccccac 5160
cagggttgtt ctttctgaaa tgaaggaggc ttttcacggc ctggacgtga aattccacac 5220
acaggctttt tccgctcacg gcagcgggag agaagtcatt gatgccatgt gccatgccac 5280
cctaacttac aggatgttgg aaccaactag ggttgttaac tgggaagtga tcattatgga 5340
tgaagcccat tttttggatc cagctagcat agccgctaga ggttgggcag cgcacagagc 5400
tagggcaaat gaaagtgcaa caatcttgat gacagccaca ccgcctggga ctagtgatga 5460
atttccacat tcaaatggtg aaatagaaga tgttcaaacg gacataccca gtgagccctg 5520
gaacacaggg catgactgga tcctggctga caaaaggccc acggcatggt tccttccatc 5580
catcagagct gcaaatgtca tggctgcctc tttgcgtaag gctggaaaga gtgtggtggt 5640
cctgaacagg aaaacctttg agagagaata ccccacgata aagcagaaga aacctgactt 5700
tatattggcc actgacatag ctgaaatggg agccaacctt tgcgtggagc gagtgctgga 5760
ttgcaggacg gcttttaagc ctgtgcttgt ggatgaaggg aggaaggtgg caataaaagg 5820
gccacttcgt atctccgcat cctctgctgc tcaaaggagg gggcgcattg ggagaaatcc 5880
caacagagat ggagactcat actactattc tgagcctaca agtgaaaata atgcccacca 5940
cgtctgctgg ttggaggcct caatgctctt ggacaacatg gaggtgaggg gtggaatggt 6000
cgccccactc tatggcgttg aaggaactaa aacaccagtt tcccctggtg aaatgagact 6060
gagggatgac cagaggaaag tcttcagaga actagtgagg aattgtgacc tgcccgtttg 6120
gctttcgtgg caagtggcca aggctggttt gaagacgaat gatcgtaagt ggtgttttga 6180
aggccctgag gaacatgaga tcttgaatga cagcggtgaa acagtgaagt gcagggctcc 6240
tggaggagca aagaagcctc tgcgcccaag gtggtgtgat gaaagggtgt catctgacca 6300
gagtgcgctg tctgaattta ttaagtttgc tgaaggtagg aggggagctg ctgaagtgct 6360
agttgtgctg agtgaactcc ctgatttcct ggctaaaaaa ggtggagagg caatggatac 6420
catcagtgtg ttcctccact ctgaggaagg ctctagggct taccgcaatg cactatcaat 6480
gatgcctgag gcaatgacaa tagtcatgct gtttatactg gctggactac tgacatcggg 6540
aatggtcatc tttttcatgt ctcccaaagg catcagtaga atgtctatgg cgatgggcac 6600
aatggccggc tgtggatatc tcatgttcct tggaggcgtc aaacccactc acatctccta 6660
tgtcatgctc atattctttg tcctgatggt ggttgtgatc cccgagccag ggcaacaaag 6720
gtccatccaa gacaaccaag tggcatacct cattattggc atcctgacgc tggtttcagc 6780
ggtggcagcc aacgagctag gcatgctgga gaaaaccaaa gaggacctct ttgggaagaa 6840
gaacttaatt ccatctagtg cttcaccctg gagttggccg gatcttgacc tgaagccagg 6900
agctgcctgg acagtgtacg ttggcattgt tacaatgctc tctccaatgt tgcaccactg 6960
gatcaaagtc gaatatggca acctgtctct gtctggaata gcccagtcag cctcagtcct 7020
ttctttcatg gacaagggga taccattcat gaagatgaat atctcggtca taatgctgct 7080
ggtcagtggc tggaattcaa taacagtgat gcctctgctc tgtggcatag ggtgcgccat 7140
gctccactgg tctctcattt tacctggaat caaagcgcag cagtcaaagc ttgcacagag 7200
aagggtgttc catggcgttg ccaagaaccc tgtggttgat gggaatccaa cagttgacat 7260
tgaggaagct cctgaaatgc ctgcccttta tgagaagaaa ctggctctat atctccttct 7320
tgctctcagc ctagcttctg ttgccatgtg cagaacgccc ttttcattgg ctgaaggcat 7380
tgtcctagca tcagctgcct tagggccgct catagaggga aacaccagcc ttctttggaa 7440
tggacccatg gctgtctcca tgacaggagt catgaggggg aatcactatg cttttgtggg 7500
agtcatgtac aatctatgga agatgaaaac tggacgccgg gggagcgcga atggaaaaac 7560
tttgggtgaa gtctggaaga gggaactgaa tctgttggac aagcgacagt ttgagttgta 7620
taaaaggacc gacattgtgg aggtggatcg tgatacggca cgcaggcatt tggccgaagg 7680
gaaggtggac accggggtgg cggtctccag ggggaccgca aagttaaggt ggttccatga 7740
gcgtggctat gtcaagctgg aaggtagggt gattgacctg gggtgtggcc gcggaggctg 7800
gtgttactac gctgctgcgc aaaaggaagt gagtggggtc aaaggattta ctcttggaag 7860
agacggccat gagaaaccca tgaatgtgca aagtctggga tggaacatca tcaccttcaa 7920
ggacaaaact gatatccacc gcctagaacc agtgaaatgt gacacccttt tgtgtgacat 7980
tggagagtca tcatcgtcat cggtcacaga gggggaaagg accgtgagag ttcttgatac 8040
tgtagaaaaa tggctggctt gtggggttga caacttctgt gtgaaggtgt tagctccata 8100
catgccagat gttcttgaga aactggaatt gctccaaagg aggtttggcg gaacagtgat 8160
caggaaccct ctctccagga attccactca tgaaatgtac tacgtgtctg gagcccgcag 8220
caatgtcaca tttactgtga accaaacatc ccgcctcctg atgaggagaa tgaggcgtcc 8280
aactggaaaa gtgaccctgg aggctgacgt catcctccca attgggacac gcagtgttga 8340
gacagacaag ggacccctgg acaaagaggc catagaagaa agggttgaga ggataaaatc 8400
tgagtacatg acctcttggt tttatgacaa tgacaacccc tacaggacct ggcactactg 8460
tggctcctat gtcacaaaaa cctcaggaag tgcggcgagc atggtaaatg gtgttattaa 8520
aattctgaca tatccatggg acaggataga ggaggtcaca agaatggcaa tgactgacac 8580
aacccctttt ggacagcaaa gagtgtttaa agaaaaagtt gacaccagag caaaggatcc 8640
accagcggga actaggaaga tcatgaaagt tgtcaacagg tggctgttcc gccacctggc 8700
cagagaaaag aaccccagac tgtgcacaaa ggaagaattt attgcaaaag tccgaagtca 8760
tgcagccatt ggagcttacc tggaagaaca agaacagtgg aagactgcca atgaggctgt 8820
ccaagaccca aagttctggg aactggtgga tgaagaaagg aagctgcacc aacaaggcag 8880
gtgtcggact tgtgtgtaca acatgatggg gaaaagagag aagaagctgt cagagtttgg 8940
gaaagcaaag ggaagccgtg ccatatggta tatgtggctg ggagcgcggt atcttgagtt 9000
tgaggccctg ggattcctga atgaggacca ttgggcttcc agggaaaact caggaggagg 9060
agtggaaggc attggcttac aatacctagg atatgtgatc agagacctgg ctgcaatgga 9120
tggtggtgga ttctacgcgg atgacaccgc tggatgggac acgcgcatca cagaggcaga 9180
ccttgatgat gaacaggaga tcttgaacta catgagccca catcacaaaa aactggcaca 9240
agcagtgatg gaaatgacat acaagaacaa agtggtgaaa gtgttgagac cagccccagg 9300
agggaaagcc tacatggatg tcataagtcg acgagaccag agaggatccg ggcaggtagt 9360
gacttatgct ctgaacacca tcaccaactt gaaagtccaa ttgatcagaa tggcagaagc 9420
agagatggtg atacatcacc aacatgttca agattgtgat gaatcagttc tgaccaggct 9480
ggaggcatgg ctcactgagc acggatgtga cagactgaag aggatggcgg tgagtggaga 9540
cgactgtgtg gtccggccca tcgatgacag gttcggcctg gccctgtccc atctcaacgc 9600
catgtccaag gttagaaagg acatatctga atggcagcca tcaaaagggt ggaatgattg 9660
ggagaatgtg cccttctgtt cccaccactt ccatgaacta cagctgaagg atggcaggag 9720
gattgtggtg ccttgccgag aacaggacga gctcattggg agaggaaggg tgtctccagg 9780
aaacggctgg atgatcaagg aaacagcttg cctcagcaaa gcctatgcca acatgtggtc 9840
actgatgtat tttcacaaaa gggacatgag gctactgtca ttggctgttt cctcagctgt 9900
tcccacctca tgggttccac aaggacgcac aacatggtcg attcatggga aaggggagtg 9960
gatgaccacg gaagacatgc ttgaggtgtg gaacagagta tggataacca acaacccaca 10020
catgcaggac aagacaatgg tgaaaaaatg gagagatgtc ccttatctaa ccaagagaca 10080
agacaagctg tgcggatcac tgattggaat gaccaatagg gccacctggg cctcccacat 10140
ccatttagtc atccatcgta tccgaacgct gattggacag gagaaataca ctgactacct 10200
aacagtcatg gacaggtatt ctgtggatgc tgacctgcaa ctgggtgagc ttatctgaaa 10260
caccatctaa caggaataac cgggatacaa accacgggtg gagaaccgga ctccccacaa 10320
cctgaaaccg ggatataaac cacggctgga gaaccggact ccgcacttaa aatgaaacag 10380
aaaccgggat aaaaactacg gatggagaac cggactccac acattgagac agaagaagtt 10440
gtcagcccag aaccccacac gagttttgcc actgctaagc tgtgaggcag tgcaggctgg 10500
gacagccgac ctccaggttg cgaaaaacct ggtttctggg acctcccacc ccagagtaaa 10560
aagaacggag cctccgctac caccctccca cgtggtggta gaaagacggg gtctagaggt 10620
tagaggagac cctccaggga acaaatagtg ggaccatatt gacgccaggg aaagaccgga 10680
gtggttctct gcttttcctc cagaggtctg tgagcacagt ttgctcaaga ataagcagac 10740
ctttggatga caaacacaaa accactcgag 10770
<210> 105
<211> 10948
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 105
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttgggaac agagagacgt taatggagtt tgaggaacca 1620
cacgccacga agcagtctgt gatagcattg ggctcacaag agggagctct gcatcaagct 1680
ttggctggag ccattcctgt ggaattttca agcaacactg tcaagttgac gtcgggtcat 1740
ttgaagtgta gagtgaagat ggaaaaattg cagttgaagg gaacaaccta tggcgtctgt 1800
tcaaaggctt tcaagtttct tgggactccc gcagacacag gtcacggcac tgtggtgttg 1860
gaattgcagt acactggcac ggatggacct tgcaaagttc ctatctcgtc agtggcttca 1920
ttgaacgacc taacgccagt gggcagattg gtcactgtca acccttttgt ttcagtggcc 1980
acggccaacg ctaaggtcct gattgaattg gaaccaccct ttggagactc atacatagtg 2040
gtgggcagag gagaacaaca gattaatcac cattggcaca agtctggaag cagcattggc 2100
aaagccttta caaccaccct caaaggagcg cagagactag ccgctctagg agacacagct 2160
tgggactttg gatcagttgg aggggtgttc acctcagttg ggaaggctgt ccatcaagtg 2220
ttcggaggag cattccgctc actgttcgga ggcatgtcct ggataacgca aggattgctg 2280
ggggctctcc tgttgtggat gggcatcaat gctcgtgata ggtccatagc tctcacgttt 2340
ctcgcagttg gaggagttct gctcttcctc tccgtgaacg tgcacgctga cactgggtgt 2400
gccatagaca tcagccggca agagctgaga tgtggaagtg gagtgttcat acacaatgat 2460
gtggaggctt ggatggaccg gtacaagtat taccctgaaa cgccacaagg cctagccaag 2520
atcattcaga aagctcataa ggaaggagtg tgcggtctac gatcagtttc cagactggag 2580
catcaaatgt gggaagcagt gaaggacgag ctgaacactc ttttgaagga gaatggtgtg 2640
gaccttagtg tcgtggttga gaaacaggag ggaatgtaca agtcagcacc taaacgcctc 2700
accgccacca cggaaaaact ggaaattggc tggaaggcct ggggaaagag tattttattt 2760
gcaccagaac tcgccaacaa cacctttgtg gttgatggtc cggagaccaa ggaatgtccg 2820
actcagaatc gcgcttggaa tagcttagaa gtggaggatt ttggatttgg tctcaccagc 2880
actcggatgt tcctgaaggt cagagagagc aacacaactg aatgtgactc gaagatcatt 2940
ggaacggctg tcaagaacaa cttggcgatc cacagtgacc tgtcctattg gattgaaagc 3000
aggctcaatg atacgtggaa gcttgaaagg gcagttctgg gtgaagtcaa atcatgtacg 3060
tggcctgaga cgcatacctt gtggggcgat ggaatccttg agagtgactt gataatacca 3120
gtcacactgg cgggaccacg aagcaatcac aatcggagac ctgggtacaa gacacaaaac 3180
cagggcccat gggacgaagg ccgggtagag attgacttcg attactgccc aggaactacg 3240
gtcaccctga gtgagagctg cggacaccgt ggacctgcca ctcgcaccac cacagagagc 3300
ggaaagttga taacagattg gtgctgcagg agctgcacct taccaccact gcgctaccaa 3360
actgacagcg gctgttggta tggtatggag atcagaccac agagacatga tgaaaagacc 3420
ctcgtgcagt cacaagtgaa tgcttataat gctgatatga ttgacccttt tcagttgggc 3480
cttctggtcg tgttcttggc cacccaggag gtccttcgca agaggtggac agccaagatc 3540
agcatgccag ctatactgat tgctctgcta gtcctggtgt ttgggggcat tacttacact 3600
gatgtgttac gctatgtcat cttggtgggg gcagctttcg cagaatctaa ttcgggagga 3660
gacgtggtac acttggcgct catggcgacc ttcaagatac aaccagtgtt tatggtggca 3720
tcgtttctca aagcgagatg gaccaaccag gagaacattt tgttgatgtt ggcggctgtt 3780
ttctttcaaa tggcttatca cgatgcccgc caaattctgc tctgggagat ccctgatgtg 3840
ttgaattcac tggcggtagc ttggatgata ctgagagcca taacattcac aacgacatca 3900
aacgtggttg ttccgctgct agccctgcta acacccgggc tgagatgctt gaatctggat 3960
gtgtacagga tactgctgtt gatggtcgga ataggcagct tgatcaggga gaagaggagt 4020
gcagctgcaa aaaagaaagg agcaagtctg ctatgcttgg ctctagcctc aacaggactt 4080
ttcaacccca tgatccttgc tgctggactg attgcatgtg atcccaaccg taaacgcgga 4140
tggcccgcaa ctgaagtgat gacagctgtc ggcctaatgt ttgccatcgt cggagggctg 4200
gcagagcttg acattgactc catggccatt ccaatgacta tcgcggggct catgtttgct 4260
gctttcgtga tttctgggaa atcaacagat atgtggattg agagaacggc ggacatttcc 4320
tgggaaagtg atgcagaaat tacaggctcg agcgaaagag ttgatgtgcg gcttgatgat 4380
gatggaaact tccagctcat gaatgatcca ggagcacctt ggaagatatg gatgctcaga 4440
atggtctgtc tcgcgattag tgcgtacacc ccctgggcaa tcttgccctc agtagttgga 4500
ttttggataa ctctccaata cacaaagaga ggaggtgtgt tgtgggacac tccctcacca 4560
aaggagtaca aaaaggggga cacgaccacc ggcgtctaca ggatcatgac tcgtgggctg 4620
ctcggcagtt atcaagcagg agcgggcgtg atggttgaag gtgttttcca caccctttgg 4680
catacaacaa aaggagccgc tttgatgagc ggagagggcc gcctggaccc atactggggc 4740
agtgtcaagg aggatcgact ttgttacgga ggaccctgga aattgcagca caagtggaac 4800
gggcaggatg aggtgcagat gattgtggtg gaacctggca agaacgttaa gaacgtccag 4860
acgaaaccag gggtgttcaa aacacctgaa ggagaaatcg gggccgtgac tttggacttc 4920
cccactggaa catcaggctc accaatagtg gacaaaaacg gtgatgtgat tgggctttat 4980
ggcaatggag tcataatgcc caacggctca tacataagcg cgatagtgca gggtgaaagg 5040
atggatgagc caatcccagc cggattcgaa cctgagatgc tgaggaaaaa acagatcact 5100
gtactggatc tccatcccgg cgccggtaaa acaaggagga ttctgccaca gatcatcaaa 5160
gaggccataa acagaagact gagaacagcc gtgctagcac caaccagggt tgtggctgct 5220
gagatggctg aagcactgag aggactgccc atccggtacc agacatccgc agtgcccaga 5280
gaacataatg gaaatgagat tgttgatgtc atgtgtcatg ctaccctcac ccacaggctg 5340
atgtctcctc acagggtgcc gaactacaac ctgttcgtga tggatgaggc tcatttcacc 5400
gacccagcta gtatcgcagc aagaggttac atttccacaa aggtcgagct aggggaggcg 5460
gcggcaatat tcatgacagc caccccacca ggcacttcag atccattccc agagtccaat 5520
tcaccaattt ccgacttaca gactgagatc ccggatcgag cttggaactc tggatacgaa 5580
tggatcacag aatacaccgg gaagacggtt tggtttgtgc ctagtgtcaa gatggggaat 5640
gagattgccc tttgcctaca acgtgctgga aagaaagtag tccaattgaa cagaaagtcg 5700
tacgagacgg agtacccaaa atgtaagaac gatgattggg actttgttat cacaacagac 5760
atatctgaaa tgggggctaa cttcaaggcg agcagggtga ttgacagccg gaagagtgtg 5820
aaaccaacca tcataacaga aggagaaggg agagtgatcc tgggagaacc atctgcagtg 5880
acagcagcta gtgccgccca gagacgtgga cgtatcggta gaaatccgtc gcaagttggt 5940
gatgagtact gttatggggg gcacacgaat gaagacgact cgaacttcgc ccattggact 6000
gaggcacgaa tcatgctgga caacatcaac atgccaaacg gactgatcgc tcaattctac 6060
caaccagagc gtgagaaggt atataccatg gatggggaat accggctcag aggagaagag 6120
aggaaaaact ttctggaact gttgaggact gcagatctgc cagtttggct ggcttacaag 6180
gttgcagcgg ctggagtgtc ataccacgac cggaggtggt gctttgatgg tcctaggaca 6240
aacacaattt tagaagacaa caacgaagtg gaagtcatca cgaagcttgg tgaaaggaag 6300
attctgaggc cgcgctggat tgacgccagg gtgtactcgg atcaccaggc actaaaggcg 6360
ttcaaggact tcgcctcggg aaaacgttct cagatagggc tcattgaggt tctgggaaag 6420
atgcctgagc acttcatggg gaagacatgg gaagcacttg acaccatgta cgtagtggcc 6480
actgcagaga aaggaggaag agctcacaga atggccctgg aggaactgcc agatgctctt 6540
cagacaattg ccttgattgc cttattgagt gtgatgacca tgggagtatt cttcctcctc 6600
atgcagcgga agggcattgg aaagataggt ttgggaggcg ctgtcttggg agtcgcgacc 6660
tttttctgtt ggatggctga agttccagga acgaagatcg ccggaatgtt gctgctctcc 6720
cttctcttga tgattgtgct aattcctgag ccagagaagc aacgttcgca gacagacaac 6780
cagctagccg tgttcctgat ttgtgtcatg acccttgtga gcgcagtggc agccaacgag 6840
atgggttggc tagataagac caagagtgac ataagcagtt tgtttgggca aagaattgag 6900
gtcaaggaga atttcagcat gggagagttt cttctggact tgaggccggc aacagcctgg 6960
tcactgtacg ctgtgacaac agcggtcctc actccactgc taaagcattt gatcacgtca 7020
gattacatca acacctcatt gacctcaata aacgttcagg caagtgcact attcacactc 7080
gcgcgaggct tccccttcgt cgatgttgga gtgtcggctc tcctgctagc agccggatgc 7140
tggggacaag tcaccctcac cgttacggta acagcggcaa cactcctttt ttgccactat 7200
gcctacatgg ttcccggttg gcaagctgag gcaatgcgct cagcccagcg gcggacagcg 7260
gccggaatca tgaagaacgc tgtagtggat ggcatcgtgg ccacggacgt cccagaatta 7320
gagcgcacca cacccatcat gcagaagaaa gttggacaga tcatgctgat cttggtgtct 7380
ctagctgcag tagtagtgaa cccgtctgtg aagacagtac gagaagccgg aattttgatc 7440
acggccgcag cggtgacgct ttgggagaat ggagcaagct ctgtttggaa cgcaacaact 7500
gccatcggac tctgccacat catgcgtggg ggttggttgt catgtctatc cataacatgg 7560
acactcataa agaacatgga aaaaccagga ctaaaaagag gtggggcaaa aggacgcacc 7620
ttgggagagg tttggaaaga aagactcaac cagatgacaa aagaagagtt cactaggtac 7680
cgcaaagagg ccatcatcga agtcgatcgc tcagcggcaa aacacgccag gaaagaaggc 7740
aatgtcactg gagggcattc agtctctagg ggcacagcaa aactgagatg gctggtcgaa 7800
cggaggtttc tcgaaccggt cggaaaagtg attgaccttg gatgtggaag aggcggttgg 7860
tgttactata tggcaaccca aaaaagagtc caagaagtca gagggtacac aaagggcggt 7920
cccggacatg aagagcccca actagtgcaa agttatggat ggaacattgt caccatgaag 7980
agtggagtgg atgtgttcta cagaccttct gagtgttgtg acaccctcct ttgtgacatc 8040
ggagagtcct cgtcaagtgc tgaggttgaa gagcatagga cgattcgtgt ccttgaaatg 8100
gttgaggact ggctgcaccg agggccaagg gaattttgcg tgaaggtgct ctgcccctac 8160
atgccgaaag tcatagagaa gatggagctg ctccaacgcc ggtatggggg gggactggtc 8220
agaaacccac tctcacggaa ttccacgcac gagatgtatt gggtgagtcg agcttcaggc 8280
aatgtggtac attcagtgaa tatgaccagc caggtgctcc taggaagaat ggaaaaaagg 8340
acctggaagg gaccccaata cgaggaagat gtaaacttgg gaagtggaac cagggcggtg 8400
ggaaaacccc tgctcaactc agacaccagt aaaatcaaga acaggattga acgactcagg 8460
cgtgagtaca gttcgacgtg gcaccacgat gagaaccacc catatagaac ctggaactat 8520
cacggcagtt atgatgtgaa gcccacaggc tccgccagtt cgctggtcaa tggagtggtc 8580
aggctcctct caaaaccatg ggacaccatc acgaatgtta ccaccatggc catgactgac 8640
actactccct tcgggcagca gcgagtgttc aaagagaagg tggacacgaa agctcctgaa 8700
ccgccagaag gagcgaagta cgtgctcaac gagaccacca actggttgtg ggcgtttttg 8760
gccagagaaa aacgtcccag aatgtgctct cgagaggaat tcataagaaa ggtcaacagc 8820
aatgcagctt tgggtgccat gtttgaagag cagaatcaat ggaggagcgc cagagaagca 8880
gttgaagatc caaaattttg ggagatggtg gatgaggagc gcgaggcaca tctgcggggg 8940
gaatgtcaca cttgcattta caacatgatg ggaaagagag agaaaaaacc cggagagttc 9000
ggaaaggcca agggaagcag agccatttgg ttcatgtggc tcggagctcg ctttctggag 9060
ttcgaggctc tgggttttct caatgaagac cactggcttg gaagaaagaa ctcaggagga 9120
ggtgtcgagg gcttgggcct ccaaaaactg ggttacatcc tgcgtgaagt tggcacccgg 9180
cctgggggca agatctatgc tgatgacaca gctggctggg acacccgcat cacgagagct 9240
gacttggaaa atgaagctaa ggtgcttgag ctgcttgatg gggaacatcg gcgtcttgcc 9300
agggccatca ttgagctcac ctatcgtcac aaagttgtga aagtgatgcg cccggctgct 9360
gatggaagaa ccgtcatgga tgttatctcc agagaagatc agagggggag tggacaagtt 9420
gtcacctacg ccctaaacac tttcaccaac ctggccgtcc agctggtgag gatgatggaa 9480
ggggaaggag tgattggccc agatgatgtg gagaaactca caaaagggaa aggacccaaa 9540
gtcaggacct ggctgtttga gaatggggaa gaaagactca gccgcatggc tgtcagtgga 9600
gatgactgtg tggtaaagcc cctggacgat cgctttgcca cctcgctcca cttcctcaat 9660
gctatgtcaa aggttcgcaa agacatccaa gagtggaaac cgtcaactgg atggtatgat 9720
tggcagcagg ttccattttg ctcaaaccat ttcactgaat tgatcatgaa agatggaaga 9780
acactggtgg ttccatgccg aggacaggat gaattggtag gcagagctcg catatctcca 9840
ggggccggat ggaacgtccg cgacactgct tgtctggcta agtcttatgc ccagatgtgg 9900
ctgcttctgt acttccacag aagagacctg cggctcatgg ccaacgccat ttgctccgct 9960
gtccctgtga attgggtccc taccggaaga accacgtggt ccatccatgc aggaggagag 10020
tggatgacaa cagaggacat gttggaggtc tggaaccgtg tttggataga ggagaatgaa 10080
tggatggaag acaaaacccc agtggagaaa tggagtgacg tcccatattc aggaaaacga 10140
gaggacatct ggtgtggcag cctgattggc acaagagccc gagccacgtg ggcagaaaac 10200
atccaggtgg ctatcaacca agtcagagca atcatcggag atgagaagta tgtggattac 10260
atgagttcac taaagagata tgaagacaca actttggttg aggacacagt actgtagata 10320
tttaatcaat tgtaaataga caatataagt atgcataaaa gtgtagtttt atagtagtat 10380
ttagtggtgt tagtgtaaat agttaagaaa attttgagga gaaagtcagg ccgggaagtt 10440
cccgccaccg gaagttgagt agacggtgct gcctgcgact caaccccagg aggactgggt 10500
gaacaaagcc gcgaagtgat ccatgtaagc cctcagaacc gtctcggaag gaggacccca 10560
catgttgtaa cttcaaagcc caatgtcaga ccacgctacg gcgtgctact ctgcggagag 10620
tgcagtctgc gatagtgccc caggaggact gggttaacaa aggcaaatca acgccccacg 10680
cggccctagc cccggtaatg gtgttaacca gggcgaaagg actagaggtt agaggagacc 10740
ccgcggttta aagtgcacgg cccagcctgg ctgaagctgt aggtcagggg aaggactaga 10800
ggttagtgga gaccccgtgc cacaaaacac cacaacaaaa cagcatattg acacctggga 10860
tagactagga gatcttctgc tctgcacaac cagccacacg gcacagtgcg ccgacaatgg 10920
tggctggtgg tgcgagaaca caggatct 10948
<210> 106
<211> 10794
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 106
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc 1620
atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg 1680
ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa 1740
gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact 1800
gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag 1860
ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca 1920
ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt 1980
cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc 2040
aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc 2100
tttggagact catacatagt ggtgggcaga ggagaacaac agattaatca ccattggcac 2160
aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta 2220
gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt 2280
gggaaggctg tccatcaaac aatgatgtgg aggcttggat ggaccggtac aagtattacc 2340
ctgaaacgcc acaaggccta gccaagatca ttcagaaagc tcataaggaa ggagtgtgcg 2400
gtctacgatc agtttccaga ctggagcatc aaatgtggga agcagtgaag gacgagctga 2460
acactctttt gaaggagaat ggtgtggacc ttagtgtcgt ggttgagaaa caggagggaa 2520
tgtacaagtc agcacctaaa cgcctcaccg ccaccacgga aaaactggaa attggctgga 2580
aggcctgggg aaagagtatt ttatttgcac cagaactcgc caacaacacc tttgtggttg 2640
atggtccgga gaccaaggaa tgtccgactc agaatcgcgc ttggaatagc ttagaagtgg 2700
aggattttgg atttggtctc accagcactc ggatgttcct gaaggtcaga gagagcaaca 2760
caactgaatg tgactcgaag atcattggaa cggctgtcaa gaacaacttg gcgatccaca 2820
gtgacctgtc ctattggatt gaaagcaggc tcaatgatac gtggaagctt gaaagggcag 2880
ttctgggtga agtcaaatca tgtacgtggc ctgagacgca taccttgtgg ggcgatggaa 2940
tccttgagag tgacttgata ataccagtca cactggcggg accacgaagc aatcacaatc 3000
ggagacctgg gtacaagaca caaaaccagg gcccatggga cgaaggccgg gtagagattg 3060
acttcgatta ctgcccagga actacggtca ccctgagtga gagctgcgga caccgtggac 3120
ctgccactcg caccaccaca gagagcggaa agttgataac agattggtgc tgcaggagct 3180
gcaccttacc accactgcgc taccaaactg acagcggctg ttggtatggt atggagatca 3240
gaccacagag acatgatgaa aagaccctcg tgcagtcaca agtgaatgct tataatgctg 3300
atatgattga cccttttcag ttgggccttc tggtcgtgtt cttggccacc caggaggtcc 3360
ttcgcaagag gtggacagcc aagatcagca tgccagctat actgattgct ctgctagtcc 3420
tggtgtttgg gggcattact tacactgatg tgttacgcta tgtcatcttg gtgggggcag 3480
ctttcgcaga atctaattcg ggaggagacg tggtacactt ggcgctcatg gcgaccttca 3540
agatacaacc agtgtttatg gtggcatcgt ttctcaaagc gagatggacc aaccaggaga 3600
acattttgtt gatgttggcg gctgttttct ttcaaatggc ttatcacgat gcccgccaaa 3660
ttctgctctg ggagatccct gatgtgttga attcactggc ggtagcttgg atgatactga 3720
gagccataac attcacaacg acatcaaacg tggttgttcc gctgctagcc ctgctaacac 3780
ccgggctgag atgcttgaat ctggatgtgt acaggatact gctgttgatg gtcggaatag 3840
gcagcttgat cagggagaag aggagtgcag ctgcaaaaaa gaaaggagca agtctgctat 3900
gcttggctct agcctcaaca ggacttttca accccatgat ccttgctgct ggactgattg 3960
catgtgatcc caaccgtaaa cgcggatggc ccgcaactga agtgatgaca gctgtcggcc 4020
taatgtttgc catcgtcgga gggctggcag agcttgacat tgactccatg gccattccaa 4080
tgactatcgc ggggctcatg tttgctgctt tcgtgatttc tgggaaatca acagatatgt 4140
ggattgagag aacggcggac atttcctggg aaagtgatgc agaaattaca ggctcgagcg 4200
aaagagttga tgtgcggctt gatgatgatg gaaacttcca gctcatgaat gatccaggag 4260
caccttggaa gatatggatg ctcagaatgg tctgtctcgc gattagtgcg tacaccccct 4320
gggcaatctt gccctcagta gttggatttt ggataactct ccaatacaca aagagaggag 4380
gtgtgttgtg ggacactccc tcaccaaagg agtacaaaaa gggggacacg accaccggcg 4440
tctacaggat catgactcgt gggctgctcg gcagttatca agcaggagcg ggcgtgatgg 4500
ttgaaggtgt tttccacacc ctttggcata caacaaaagg agccgctttg atgagcggag 4560
agggccgcct ggacccatac tggggcagtg tcaaggagga tcgactttgt tacggaggac 4620
cctggaaatt gcagcacaag tggaacgggc aggatgaggt gcagatgatt gtggtggaac 4680
ctggcaagaa cgttaagaac gtccagacga aaccaggggt gttcaaaaca cctgaaggag 4740
aaatcggggc cgtgactttg gacttcccca ctggaacatc aggctcacca atagtggaca 4800
aaaacggtga tgtgattggg ctttatggca atggagtcat aatgcccaac ggctcataca 4860
taagcgcgat agtgcagggt gaaaggatgg atgagccaat cccagccgga ttcgaacctg 4920
agatgctgag gaaaaaacag atcactgtac tggatctcca tcccggcgcc ggtaaaacaa 4980
ggaggattct gccacagatc atcaaagagg ccataaacag aagactgaga acagccgtgc 5040
tagcaccaac cagggttgtg gctgctgaga tggctgaagc actgagagga ctgcccatcc 5100
ggtaccagac atccgcagtg cccagagaac ataatggaaa tgagattgtt gatgtcatgt 5160
gtcatgctac cctcacccac aggctgatgt ctcctcacag ggtgccgaac tacaacctgt 5220
tcgtgatgga tgaggctcat ttcaccgacc cagctagtat cgcagcaaga ggttacattt 5280
ccacaaaggt cgagctaggg gaggcggcgg caatattcat gacagccacc ccaccaggca 5340
cttcagatcc attcccagag tccaattcac caatttccga cttacagact gagatcccgg 5400
atcgagcttg gaactctgga tacgaatgga tcacagaata caccgggaag acggtttggt 5460
ttgtgcctag tgtcaagatg gggaatgaga ttgccctttg cctacaacgt gctggaaaga 5520
aagtagtcca attgaacaga aagtcgtacg agacggagta cccaaaatgt aagaacgatg 5580
attgggactt tgttatcaca acagacatat ctgaaatggg ggctaacttc aaggcgagca 5640
gggtgattga cagccggaag agtgtgaaac caaccatcat aacagaagga gaagggagag 5700
tgatcctggg agaaccatct gcagtgacag cagctagtgc cgcccagaga cgtggacgta 5760
tcggtagaaa tccgtcgcaa gttggtgatg agtactgtta tggggggcac acgaatgaag 5820
acgactcgaa cttcgcccat tggactgagg cacgaatcat gctggacaac atcaacatgc 5880
caaacggact gatcgctcaa ttctaccaac cagagcgtga gaaggtatat accatggatg 5940
gggaataccg gctcagagga gaagagagga aaaactttct ggaactgttg aggactgcag 6000
atctgccagt ttggctggct tacaaggttg cagcggctgg agtgtcatac cacgaccgga 6060
ggtggtgctt tgatggtcct aggacaaaca caattttaga agacaacaac gaagtggaag 6120
tcatcacgaa gcttggtgaa aggaagattc tgaggccgcg ctggattgac gccagggtgt 6180
actcggatca ccaggcacta aaggcgttca aggacttcgc ctcgggaaaa cgttctcaga 6240
tagggctcat tgaggttctg ggaaagatgc ctgagcactt catggggaag acatgggaag 6300
cacttgacac catgtacgta gtggccactg cagagaaagg aggaagagct cacagaatgg 6360
ccctggagga actgccagat gctcttcaga caattgcctt gattgcctta ttgagtgtga 6420
tgaccatggg agtattcttc ctcctcatgc agcggaaggg cattggaaag ataggtttgg 6480
gaggcgctgt cttgggagtc gcgacctttt tctgttggat ggctgaagtt ccaggaacga 6540
agatcgccgg aatgttgctg ctctcccttc tcttgatgat tgtgctaatt cctgagccag 6600
agaagcaacg ttcgcagaca gacaaccagc tagccgtgtt cctgatttgt gtcatgaccc 6660
ttgtgagcgc agtggcagcc aacgagatgg gttggctaga taagaccaag agtgacataa 6720
gcagtttgtt tgggcaaaga attgaggtca aggagaattt cagcatggga gagtttcttc 6780
tggacttgag gccggcaaca gcctggtcac tgtacgctgt gacaacagcg gtcctcactc 6840
cactgctaaa gcatttgatc acgtcagatt acatcaacac ctcattgacc tcaataaacg 6900
ttcaggcaag tgcactattc acactcgcgc gaggcttccc cttcgtcgat gttggagtgt 6960
cggctctcct gctagcagcc ggatgctggg gacaagtcac cctcaccgtt acggtaacag 7020
cggcaacact ccttttttgc cactatgcct acatggttcc cggttggcaa gctgaggcaa 7080
tgcgctcagc ccagcggcgg acagcggccg gaatcatgaa gaacgctgta gtggatggca 7140
tcgtggccac ggacgtccca gaattagagc gcaccacacc catcatgcag aagaaagttg 7200
gacagatcat gctgatcttg gtgtctctag ctgcagtagt agtgaacccg tctgtgaaga 7260
cagtacgaga agccggaatt ttgatcacgg ccgcagcggt gacgctttgg gagaatggag 7320
caagctctgt ttggaacgca acaactgcca tcggactctg ccacatcatg cgtgggggtt 7380
ggttgtcatg tctatccata acatggacac tcataaagaa catggaaaaa ccaggactaa 7440
aaagaggtgg ggcaaaagga cgcaccttgg gagaggtttg gaaagaaaga ctcaaccaga 7500
tgacaaaaga agagttcact aggtaccgca aagaggccat catcgaagtc gatcgctcag 7560
cggcaaaaca cgccaggaaa gaaggcaatg tcactggagg gcattcagtc tctaggggca 7620
cagcaaaact gagatggctg gtcgaacgga ggtttctcga accggtcgga aaagtgattg 7680
accttggatg tggaagaggc ggttggtgtt actatatggc aacccaaaaa agagtccaag 7740
aagtcagagg gtacacaaag ggcggtcccg gacatgaaga gccccaacta gtgcaaagtt 7800
atggatggaa cattgtcacc atgaagagtg gagtggatgt gttctacaga ccttctgagt 7860
gttgtgacac cctcctttgt gacatcggag agtcctcgtc aagtgctgag gttgaagagc 7920
ataggacgat tcgtgtcctt gaaatggttg aggactggct gcaccgaggg ccaagggaat 7980
tttgcgtgaa ggtgctctgc ccctacatgc cgaaagtcat agagaagatg gagctgctcc 8040
aacgccggta tgggggggga ctggtcagaa acccactctc acggaattcc acgcacgaga 8100
tgtattgggt gagtcgagct tcaggcaatg tggtacattc agtgaatatg accagccagg 8160
tgctcctagg aagaatggaa aaaaggacct ggaagggacc ccaatacgag gaagatgtaa 8220
acttgggaag tggaaccagg gcggtgggaa aacccctgct caactcagac accagtaaaa 8280
tcaagaacag gattgaacga ctcaggcgtg agtacagttc gacgtggcac cacgatgaga 8340
accacccata tagaacctgg aactatcacg gcagttatga tgtgaagccc acaggctccg 8400
ccagttcgct ggtcaatgga gtggtcaggc tcctctcaaa accatgggac accatcacga 8460
atgttaccac catggccatg actgacacta ctcccttcgg gcagcagcga gtgttcaaag 8520
agaaggtgga cacgaaagct cctgaaccgc cagaaggagc gaagtacgtg ctcaacgaga 8580
ccaccaactg gttgtgggcg tttttggcca gagaaaaacg tcccagaatg tgctctcgag 8640
aggaattcat aagaaaggtc aacagcaatg cagctttggg tgccatgttt gaagagcaga 8700
atcaatggag gagcgccaga gaagcagttg aagatccaaa attttgggag atggtggatg 8760
aggagcgcga ggcacatctg cggggggaat gtcacacttg catttacaac atgatgggaa 8820
agagagagaa aaaacccgga gagttcggaa aggccaaggg aagcagagcc atttggttca 8880
tgtggctcgg agctcgcttt ctggagttcg aggctctggg ttttctcaat gaagaccact 8940
ggcttggaag aaagaactca ggaggaggtg tcgagggctt gggcctccaa aaactgggtt 9000
acatcctgcg tgaagttggc acccggcctg ggggcaagat ctatgctgat gacacagctg 9060
gctgggacac ccgcatcacg agagctgact tggaaaatga agctaaggtg cttgagctgc 9120
ttgatgggga acatcggcgt cttgccaggg ccatcattga gctcacctat cgtcacaaag 9180
ttgtgaaagt gatgcgcccg gctgctgatg gaagaaccgt catggatgtt atctccagag 9240
aagatcagag ggggagtgga caagttgtca cctacgccct aaacactttc accaacctgg 9300
ccgtccagct ggtgaggatg atggaagggg aaggagtgat tggcccagat gatgtggaga 9360
aactcacaaa agggaaagga cccaaagtca ggacctggct gtttgagaat ggggaagaaa 9420
gactcagccg catggctgtc agtggagatg actgtgtggt aaagcccctg gacgatcgct 9480
ttgccacctc gctccacttc ctcaatgcta tgtcaaaggt tcgcaaagac atccaagagt 9540
ggaaaccgtc aactggatgg tatgattggc agcaggttcc attttgctca aaccatttca 9600
ctgaattgat catgaaagat ggaagaacac tggtggttcc atgccgagga caggatgaat 9660
tggtaggcag agctcgcata tctccagggg ccggatggaa cgtccgcgac actgcttgtc 9720
tggctaagtc ttatgcccag atgtggctgc ttctgtactt ccacagaaga gacctgcggc 9780
tcatggccaa cgccatttgc tccgctgtcc ctgtgaattg ggtccctacc ggaagaacca 9840
cgtggtccat ccatgcagga ggagagtgga tgacaacaga ggacatgttg gaggtctgga 9900
accgtgtttg gatagaggag aatgaatgga tggaagacaa aaccccagtg gagaaatgga 9960
gtgacgtccc atattcagga aaacgagagg acatctggtg tggcagcctg attggcacaa 10020
gagcccgagc cacgtgggca gaaaacatcc aggtggctat caaccaagtc agagcaatca 10080
tcggagatga gaagtatgtg gattacatga gttcactaaa gagatatgaa gacacaactt 10140
tggttgagga cacagtactg tagatattta atcaattgta aatagacaat ataagtatgc 10200
ataaaagtgt agttttatag tagtatttag tggtgttagt gtaaatagtt aagaaaattt 10260
tgaggagaaa gtcaggccgg gaagttcccg ccaccggaag ttgagtagac ggtgctgcct 10320
gcgactcaac cccaggagga ctgggtgaac aaagccgcga agtgatccat gtaagccctc 10380
agaaccgtct cggaaggagg accccacatg ttgtaacttc aaagcccaat gtcagaccac 10440
gctacggcgt gctactctgc ggagagtgca gtctgcgata gtgccccagg aggactgggt 10500
taacaaaggc aaatcaacgc cccacgcggc cctagccccg gtaatggtgt taaccagggc 10560
gaaaggacta gaggttagag gagaccccgc ggtttaaagt gcacggccca gcctggctga 10620
agctgtaggt caggggaagg actagaggtt agtggagacc ccgtgccaca aaacaccaca 10680
acaaaacagc atattgacac ctgggataga ctaggagatc ttctgctctg cacaaccagc 10740
cacacggcac agtgcgccga caatggtggc tggtggtgcg agaacacagg atct 10794
<210> 107
<211> 10978
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 107
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc 1620
atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg 1680
ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa 1740
gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact 1800
gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag 1860
ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca 1920
ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt 1980
cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc 2040
aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc 2100
tttggagact catacatagt ggtgggcaga ggagaacaac agattaatca ccattggcac 2160
aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta 2220
gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt 2280
gggaaggctg tccatcaagt gttcggagga gcattccgct cactgttcgg aggcatgtcc 2340
tggataacgc aaggattgct gggggctctc ctgttgtgga tgggcatcaa tgctcgtgat 2400
aggtccatag ctctcacgtt tctcgcagtt ggaggagttc tgctcttcct ctccgtgaac 2460
gtgcacgctg acactgggtg tgccatagac atcagccggc aagagctgag atgtggaagt 2520
ggagtgttca tacacaatga tgtggaggct tggatggacc ggtacaagta ttaccctgaa 2580
acgccacaag gcctagccaa gatcattcag aaagctcata aggaaggagt gtgcggtcta 2640
cgatcagttt ccagactgga gcatcaaatg tgggaagcag tgaaggacga gctgaacact 2700
cttttgaagg agaatggtgt ggaccttagt gtcgtggttg agaaacagga gggaatgtac 2760
aagtcagcac ctaaacgcct caccgccacc acggaaaaac tggaaattgg ctggaaggcc 2820
tggggaaaga gtattttatt tgcaccagaa ctcgccaaca acacctttgt ggttgatggt 2880
ccggagacca aggaatgtcc gactcagaat cgcgcttgga atagcttaga agtggaggat 2940
tttggatttg gtctcaccag cactcggatg ttcctgaagg tcagagagag caacacaact 3000
gaatgtgact cgaagatcat tggaacggct gtcaagaaca acttggcgat ccacagtgac 3060
ctgtcctatt ggattgaaag caggctcaat gatacgtgga agcttgaaag ggcagttctg 3120
ggtgaagtca aatcatgtac gtggcctgag acgcatacct tgtggggcga tggaatcctt 3180
gagagtgact tgataatacc agtcacactg gcgggaccac gaagcaatca caatcggaga 3240
cctgggtaca agacacaaaa ccagggccca tgggacgaag gccgggtaga gattgacttc 3300
gattactgcc caggaactac ggtcaccctg agtgagagct gcggacaccg tggacctgcc 3360
actcgcacca ccacagagag cggaaagttg ataacagatt ggtgctgcag gagctgcacc 3420
ttaccaccac tgcgctacca aactgacagc ggctgttggt atggtatgga gatcagacca 3480
cagagacatg atgaaaagac cctcgtgcag tcacaagtga atgcttataa tgctgatatg 3540
attgaccctt ttcagttggg ccttctggtc gtgttcttgg ccacccagga ggtccttcgc 3600
aagaggtgga cagccaagat cagcatgcca gctatactga ttgctctgct agtcctggtg 3660
tttgggggca ttacttacac tgatgtgtta cgctatgtca tcttggtggg ggcagctttc 3720
gcagaatcta attcgggagg agacgtggta cacttggcgc tcatggcgac cttcaagata 3780
caaccagtgt ttatggtggc atcgtttctc aaagcgagat ggaccaacca ggagaacatt 3840
ttgttgatgt tggcggctgt tttctttcaa atggcttatc acgatgcccg ccaaattctg 3900
ctctgggaga tccctgatgt gttgaattca ctggcggtag cttggatgat actgagagcc 3960
ataacattca caacgacatc aaacgtggtt gttccgctgc tagccctgct aacacccggg 4020
ctgagatgct tgaatctgga tgtgtacagg atactgctgt tgatggtcgg aataggcagc 4080
ttgatcaggg agaagaggag tgcagctgca aaaaagaaag gagcaagtct gctatgcttg 4140
gctctagcct caacaggact tttcaacccc atgatccttg ctgctggact gattgcatgt 4200
gatcccaacc gtaaacgcgg atggcccgca actgaagtga tgacagctgt cggcctaatg 4260
tttgccatcg tcggagggct ggcagagctt gacattgact ccatggccat tccaatgact 4320
atcgcggggc tcatgtttgc tgctttcgtg atttctggga aatcaacaga tatgtggatt 4380
gagagaacgg cggacatttc ctgggaaagt gatgcagaaa ttacaggctc gagcgaaaga 4440
gttgatgtgc ggcttgatga tgatggaaac ttccagctca tgaatgatcc aggagcacct 4500
tggaagatat ggatgctcag aatggtctgt ctcgcgatta gtgcgtacac cccctgggca 4560
atcttgccct cagtagttgg attttggata actctccaat acacaaagag aggaggtgtg 4620
ttgtgggaca ctccctcacc aaaggagtac aaaaaggggg acacgaccac cggcgtctac 4680
aggatcatga ctcgtgggct gctcggcagt tatcaagcag gagcgggcgt gatggttgaa 4740
ggtgttttcc acaccctttg gcatacaaca aaaggagccg ctttgatgag cggagagggc 4800
cgcctggacc catactgggg cagtgtcaag gaggatcgac tttgttacgg aggaccctgg 4860
aaattgcagc acaagtggaa cgggcaggat gaggtgcaga tgattgtggt ggaacctggc 4920
aagaacgtta agaacgtcca gacgaaacca ggggtgttca aaacacctga aggagaaatc 4980
ggggccgtga ctttggactt ccccactgga acatcaggct caccaatagt ggacaaaaac 5040
ggtgatgtga ttgggcttta tggcaatgga gtcataatgc ccaacggctc atacataagc 5100
gcgatagtgc agggtgaaag gatggatgag ccaatcccag ccggattcga acctgagatg 5160
ctgaggaaaa aacagatcac tgtactggat ctccatcccg gcgccggtaa aacaaggagg 5220
attctgccac agatcatcaa agaggccata aacagaagac tgagaacagc cgtgctagca 5280
ccaaccaggg ttgtggctgc tgagatggct gaagcactga gaggactgcc catccggtac 5340
cagacatccg cagtgcccag agaacataat ggaaatgaga ttgttgatgt catgtgtcat 5400
gctaccctca cccacaggct gatgtctcct cacagggtgc cgaactacaa cctgttcgtg 5460
atggatgagg ctcatttcac cgacccagct agtatcgcag caagaggtta catttccaca 5520
aaggtcgagc taggggaggc ggcggcaata ttcatgacag ccaccccacc aggcacttca 5580
gatccattcc cagagtccaa ttcaccaatt tccgacttac agactgagat cccggatcga 5640
gcttggaact ctggatacga atggatcaca gaatacaccg ggaagacggt ttggtttgtg 5700
cctagtgtca agatggggaa tgagattgcc ctttgcctac aacgtgctgg aaagaaagta 5760
gtccaattga acagaaagtc gtacgagacg gagtacccaa aatgtaagaa cgatgattgg 5820
gactttgtta tcacaacaga catatctgaa atgggggcta acttcaaggc gagcagggtg 5880
attgacagcc ggaagagtgt gaaaccaacc atcataacag aaggagaagg gagagtgatc 5940
ctgggagaac catctgcagt gacagcagct agtgccgccc agagacgtgg acgtatcggt 6000
agaaatccgt cgcaagttgg tgatgagtac tgttatgggg ggcacacgaa tgaagacgac 6060
tcgaacttcg cccattggac tgaggcacga atcatgctgg acaacatcaa catgccaaac 6120
ggactgatcg ctcaattcta ccaaccagag cgtgagaagg tatataccat ggatggggaa 6180
taccggctca gaggagaaga gaggaaaaac tttctggaac tgttgaggac tgcagatctg 6240
ccagtttggc tggcttacaa ggttgcagcg gctggagtgt cataccacga ccggaggtgg 6300
tgctttgatg gtcctaggac aaacacaatt ttagaagaca acaacgaagt ggaagtcatc 6360
acgaagcttg gtgaaaggaa gattctgagg ccgcgctgga ttgacgccag ggtgtactcg 6420
gatcaccagg cactaaaggc gttcaaggac ttcgcctcgg gaaaacgttc tcagataggg 6480
ctcattgagg ttctgggaaa gatgcctgag cacttcatgg ggaagacatg ggaagcactt 6540
gacaccatgt acgtagtggc cactgcagag aaaggaggaa gagctcacag aatggccctg 6600
gaggaactgc cagatgctct tcagacaatt gccttgattg ccttattgag tgtgatgacc 6660
atgggagtat tcttcctcct catgcagcgg aagggcattg gaaagatagg tttgggaggc 6720
gctgtcttgg gagtcgcgac ctttttctgt tggatggctg aagttccagg aacgaagatc 6780
gccggaatgt tgctgctctc ccttctcttg atgattgtgc taattcctga gccagagaag 6840
caacgttcgc agacagacaa ccagctagcc gtgttcctga tttgtgtcat gacccttgtg 6900
agcgcagtgg cagccaacga gatgggttgg ctagataaga ccaagagtga cataagcagt 6960
ttgtttgggc aaagaattga ggtcaaggag aatttcagca tgggagagtt tcttctggac 7020
ttgaggccgg caacagcctg gtcactgtac gctgtgacaa cagcggtcct cactccactg 7080
ctaaagcatt tgatcacgtc agattacatc aacacctcat tgacctcaat aaacgttcag 7140
gcaagtgcac tattcacact cgcgcgaggc ttccccttcg tcgatgttgg agtgtcggct 7200
ctcctgctag cagccggatg ctggggacaa gtcaccctca ccgttacggt aacagcggca 7260
acactccttt tttgccacta tgcctacatg gttcccggtt ggcaagctga ggcaatgcgc 7320
tcagcccagc ggcggacagc ggccggaatc atgaagaacg ctgtagtgga tggcatcgtg 7380
gccacggacg tcccagaatt agagcgcacc acacccatca tgcagaagaa agttggacag 7440
atcatgctga tcttggtgtc tctagctgca gtagtagtga acccgtctgt gaagacagta 7500
cgagaagccg gaattttgat cacggccgca gcggtgacgc tttgggagaa tggagcaagc 7560
tctgtttgga acgcaacaac tgccatcgga ctctgccaca tcatgcgtgg gggttggttg 7620
tcatgtctat ccataacatg gacactcata aagaacatgg aaaaaccagg actaaaaaga 7680
ggtggggcaa aaggacgcac cttgggagag gtttggaaag aaagactcaa ccagatgaca 7740
aaagaagagt tcactaggta ccgcaaagag gccatcatcg aagtcgatcg ctcagcggca 7800
aaacacgcca ggaaagaagg caatgtcact ggagggcatt cagtctctag gggcacagca 7860
aaactgagat ggctggtcga acggaggttt ctcgaaccgg tcggaaaagt gattgacctt 7920
ggatgtggaa gaggcggttg gtgttactat atggcaaccc aaaaaagagt ccaagaagtc 7980
agagggtaca caaagggcgg tcccggacat gaagagcccc aactagtgca aagttatgga 8040
tggaacattg tcaccatgaa gagtggagtg gatgtgttct acagaccttc tgagtgttgt 8100
gacaccctcc tttgtgacat cggagagtcc tcgtcaagtg ctgaggttga agagcatagg 8160
acgattcgtg tccttgaaat ggttgaggac tggctgcacc gagggccaag ggaattttgc 8220
gtgaaggtgc tctgccccta catgccgaaa gtcatagaga agatggagct gctccaacgc 8280
cggtatgggg ggggactggt cagaaaccca ctctcacgga attccacgca cgagatgtat 8340
tgggtgagtc gagcttcagg caatgtggta cattcagtga atatgaccag ccaggtgctc 8400
ctaggaagaa tggaaaaaag gacctggaag ggaccccaat acgaggaaga tgtaaacttg 8460
ggaagtggaa ccagggcggt gggaaaaccc ctgctcaact cagacaccag taaaatcaag 8520
aacaggattc catatagaac ctggaactat cacggcagtt atgatgtgaa gcccacaggc 8580
tccgccagtt cgctggtcaa tggagtggtc aggctcctct caaaaccatg ggacaccatc 8640
acgaatgtta ccaccatggc catgactgac actactccct tcgggcagca gcgagtgttc 8700
aaagagaagg tggacacgaa agctcctgaa ccgccagaag gagcgaagta cgtgctcaac 8760
gagaccacca actggttgtg ggcgtttttg gccagagaaa aacgtcccag aatgtgctct 8820
cgagaggaat tcataagaaa ggtcaacagc aatgcagctt tgggtgccat gtttgaagag 8880
cagaatcaat ggaggagcgc cagagaagca gttgaagatc caaaattttg ggagatggtg 8940
gatgaggagc gcgaggcaca tctgcggggg gaatgtcaca cttgcattta caacatgatg 9000
ggaaagagag agaaaaaacc cggagagttc ggaaaggcca agggaagcag agccatttgg 9060
ttcatgtggc tcggagctcg ctttctggag ttcgaggctc tgggttttct caatgaagac 9120
cactggcttg gaagaaagaa ctcaggagga ggtgtcgagg gcttgggcct ccaaaaactg 9180
ggttacatcc tgcgtgaagt tggcacccgg cctgggggca agatctatgc tgatgacaca 9240
gctggctggg acacccgcat cacgagagct gacttggaaa atgaagctaa ggtgcttgag 9300
ctgcttgatg gggaacatcg gcgtcttgcc agggccatca ttgagctcac ctatcgtcac 9360
aaagttgtga aagtgatgcg cccggctgct gatggaagaa ccgtcatgga tgttatctcc 9420
agagaagatc agagggggag tggacaagtt gtcacctacg ccctaaacac tttcaccaac 9480
ctggccgtcc agctggtgag gatgatggaa ggggaaggag tgattggccc agatgatgtg 9540
gagaaactca caaaagggaa aggacccaaa gtcaggacct ggctgtttga gaatggggaa 9600
gaaagactca gccgcatggc tgtcagtgga gatgactgtg tggtaaagcc cctggacgat 9660
cgctttgcca cctcgctcca cttcctcaat gctatgtcaa aggttcgcaa agacatccaa 9720
gagtggaaac cgtcaactgg atggtatgat tggcagcagg ttccattttg ctcaaaccat 9780
ttcactgaat tgatcatgaa agatggaaga acactggtgg ttccatgccg aggacaggat 9840
gaattggtag gcagagctcg catatctcca ggggccggat ggaacgtccg cgacactgct 9900
tgtctggcta agtcttatgc ccagatgtgg ctgcttctgt acttccacag aagagacctg 9960
cggctcatgg ccaacgccat ttgctccgct gtccctgtga attgggtccc taccggaaga 10020
accacgtggt ccatccatgc aggaggagag tggatgacaa cagaggacat gttggaggtc 10080
tggaaccgtg tttggataga ggagaatgaa tggatggaag acaaaacccc agtggagaaa 10140
tggagtgacg tcccatattc aggaaaacga gaggacatct ggtgtggcag cctgattggc 10200
acaagagccc gagccacgtg ggcagaaaac atccaggtgg ctatcaacca agtcagagca 10260
atcatcggag atgagaagta tgtggattac atgagttcac taaagagata tgaagacaca 10320
actttggttg aggacacagt actgtagata tttaatcaat tgtaaataga caatataagt 10380
atgcataaaa gtgtagtttt atagtagtat ttagtggtgt tagtgtaaat agttaagaaa 10440
attttgagga gaaagtcagg ccgggaagtt cccgccaccg gaagttgagt agacggtgct 10500
gcctgcgact caaccccagg aggactgggt gaacaaagcc gcgaagtgat ccatgtaagc 10560
cctcagaacc gtctcggaag gaggacccca catgttgtaa cttcaaagcc caatgtcaga 10620
ccacgctacg gcgtgctact ctgcggagag tgcagtctgc gatagtgccc caggaggact 10680
gggttaacaa aggcaaatca acgccccacg cggccctagc cccggtaatg gtgttaacca 10740
gggcgaaagg actagaggtt agaggagacc ccgcggttta aagtgcacgg cccagcctgg 10800
ctgaagctgt aggtcagggg aaggactaga ggttagtgga gaccccgtgc cacaaaacac 10860
cacaacaaaa cagcatattg acacctggga tagactagga gatcttctgc tctgcacaac 10920
cagccacacg gcacagtgcg ccgacaatgg tggctggtgg tgcgagaaca caggatct 10978
<210> 108
<211> 10947
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 108
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc 1620
atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg 1680
ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa 1740
gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact 1800
gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag 1860
ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca 1920
ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt 1980
cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc 2040
aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc 2100
tttggagact catacatagt ggtgggcaga ggagaacaac agattaatca ccattggcac 2160
aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta 2220
gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt 2280
gggaaggctg tccatcaagt gttcggagga gcattccgct cactgttcgg aggcatgtcc 2340
tggataacgc aaggattgct gggggctctc ctgttgtgga tgggcatcaa tgctcgtgat 2400
aggtccatag ctctcacgtt tctcgcagtt ggaggagttc tgctcttcct ctccgtgaac 2460
gtgcacgctg acactgggtg tgccatagac atcagccggc aagagctgag atgtggaagt 2520
ggagtgttca tacacaatga tgtggaggct tggatggacc ggtacaagta ttaccctgaa 2580
acgccacaag gcctagccaa gatcattcag aaagctcata aggaaggagt gtgcggtcta 2640
cgatcagttt ccagactgga gcatcaaatg tgggaagcag tgaaggacga gctgaacact 2700
cttttgaagg agaatggtgt ggaccttagt gtcgtggttg agaaacagga gggaatgtac 2760
aagtcagcac ctaaacgcct caccgccacc acggaaaaac tggaaattgg ctggaaggcc 2820
tggggaaaga gtattttatt tgcaccagaa ctcgccaaca acacctttgt ggttgatggt 2880
ccggagacca aggaatgtcc gactcagaat cgcgcttgga atagcttaga agtggaggat 2940
tttggatttg gtctcaccag cactcggatg ttcctgaagg tcagagagag caacacaact 3000
gaatgtgact cgaagatcat tggaacggct gtcaagaaca acttggcgat ccacagtgac 3060
ctgtcctatt ggattgaaag caggctcaat gatacgtgga agcttgaaag ggcagttctg 3120
ggtgaagtca aatcatgtac gtggcctgag acgcatacct tgtggggcga tggaatcctt 3180
gagagtgact tgataatacc agtcacactg gcgggaccac gaagcaatca caatcggaga 3240
cctgggtaca agacacaaaa ccagggccca tgggacgaag gccgggtaga gattgacttc 3300
gattactgcc caggaactac ggtcaccctg agtgagagct gcggacaccg tggacctgcc 3360
actcgcacca ccacagagag cggaaagttg ataacagatt ggtgctgcag gagctgcacc 3420
ttaccaccac tgcgctacca aactgacagc ggctgttggt atggtatgga gatcagacca 3480
cagagacatg atgaaaagac cctcgtgcag tcacaagtga atgcttataa tgctgatatg 3540
attgaccctt ttcagttggg ccttctggtc gtgttcttgg ccacccagga ggtccttcgc 3600
aagaggtgga cagccaagat cagcatgcca gctatactga ttgctctgct agtcctggtg 3660
tttgggggca ttacttacac tgatgtgtta cgctatgtca tcttggtggg ggcagctttc 3720
gcagaatcta attcgggagg agacgtggta cacttggcgc tcatggcgac cttcaagata 3780
caaccagtgt ttatggtggc atcgtttctc aaagcgagat ggaccaacca ggagaacatt 3840
ttgttgatgt tggcggctgt tttctttcaa atggcttatc acgatgcccg ccaaattctg 3900
ctctgggaga tccctgatgt gttgaattca ctggcggtag cttggatgat actgagagcc 3960
ataacattca caacgacatc aaacgtggtt gttccgctgc tagccctgct aacacccggg 4020
ctgagatgct tgaatctgga tgtgtacagg atactgctgt tgatggtcgg aataggcagc 4080
ttgatcaggg agaagaggag tgcagctgca aaaaagaaag gagcaagtct gctatgcttg 4140
gctctagcct caacaggact tttcaacccc atgatccttg ctgctggact gattgcatgt 4200
gatcccaacc gtaaacgcgg atggcccgca actgaagtga tgacagctgt cggcctaatg 4260
tttgccatcg tcggagggct ggcagagctt gacattgact ccatggccat tccaatgact 4320
atcgcggggc tcatgtttgc tgctttcgtg atttctggga aatcaacaga tatgtggatt 4380
gagagaacgg cggacatttc ctgggaaagt gatgcagaaa ttacaggctc gagcgaaaga 4440
gttgatgtgc ggcttgatga tgatggaaac ttccagctca tgaatgatcc aggagcacct 4500
tggaagatat ggatgctcag aatggtctgt ctcgcgatta gtgcgtacac cccctgggca 4560
atcttgccct cagtagttgg attttggata actctccaat acacaaagag aggaggtgtg 4620
ttgtgggaca ctccctcacc aaaggagtac aaaaaggggg acacgaccac cggcgtctac 4680
aggatcatga ctcgtgggct gctcggcagt tatcaagcag gagcgggcgt gatggttgaa 4740
ggtgttttcc acaccctttg gcatacaaca aaaggagccg ctttgatgag cggagagggc 4800
cgcctggacc catactgggg cagtgtcaag gaggatcgac tttgttacgg aggaccctgg 4860
aaattgcagc acaagtggaa cgggcaggat gaggtgcaga tgattgtggt ggaacctggc 4920
aagaacgtta agaacgtcca gacgaaacca ggggtgttca aaacacctga aggagaaatc 4980
ggggccgtga ctttggactt ccccactgga acatcaggct caccaatagt ggacaaaaac 5040
ggtgatgtga ttgggcttta tggcaatgga gtcataatgc ccaacggctc atacataagc 5100
gcgatagtgc agggtgaaag gatggatgag ccaatcccag ccggattcga acctgagatg 5160
ctgaggaaaa aacagatcac tgtactggat ctccatcccg gcgccggtaa aacaaggagg 5220
attctgccac agatcatcaa agaggccata aacagaagac tgagaacagc cgtgctagca 5280
ccaaccaggg ttgtggctgc tgagatggct gaagcactga gaggactgcc catccggtac 5340
cagacatccg cagtgcccag agaacataat ggaaatgaga ttgttgatgt catgtgtcat 5400
gctaccctca cccacaggct gatgtctcct cacagggtgc cgaactacaa cctgttcgtg 5460
atggatgagg ctcatttcac cgacccagct agtatcgcag caagaggtta catttccaca 5520
aaggtcgagc taggggaggc ggcggcaata ttcatgacag ccaccccacc aggcacttca 5580
gatccattcc cagagtccaa ttcaccaatt tccgacttac agactgagat cccggatcga 5640
gcttggaact ctggatacga atggatcaca gaatacaccg ggaagacggt ttggtttgtg 5700
cctagtgtca agatggggaa tgagattgcc ctttgcctac aacgtgctgg aaagaaagta 5760
gtccaattga acagaaagtc gtacgagacg gagtacccaa aatgtaagaa cgatgattgg 5820
gactttgtta tcacaacaga catatctgaa atgggggcta acttcaaggc gagcagggtg 5880
attgacagcc ggaagagtgt gaaaccaacc atcataacag aaggagaagg gagagtgatc 5940
ctgggagaac catctgcagt gacagcagct agtgccgccc agagacgtgg acgtatcggt 6000
agaaatccgt cgcaagttgg tgatgagtac tgttatgggg ggcacacgaa tgaagacgac 6060
tcgaacttcg cccattggac tgaggcacga atcatgctgg acaacatcaa catgccaaac 6120
ggactgatcg ctcaattcta ccaaccagag cgtgagaagg tatataccat ggatggggaa 6180
taccggctca gaggagaaga gaggaaaaac tttctggaac tgttgaggac tgcagatctg 6240
ccagtttggc tggcttacaa ggttgcagcg gctggagtgt cataccacga ccggaggtgg 6300
tgctttgatg gtcctaggac aaacacaatt ttagaagaca acaacgaagt ggaagtcatc 6360
acgaagcttg gtgaaaggaa gattctgagg ccgcgctgga ttgacgccag ggtgtactcg 6420
gatcaccagg cactaaaggc gttcaaggac ttcgcctcgg gaaaacgttc tcagataggg 6480
ctcattgagg ttctgggaaa gatgcctgag cacttcatgg ggaagacatg ggaagcactt 6540
gacaccatgt acgtagtggc cactgcagag aaaggaggaa gagctcacag aatggccctg 6600
gaggaactgc cagatgctct tcagacaatt gccttgattg ccttattgag tgtgatgacc 6660
atgggagtat tcttcctcct catgcagcgg aagggcattg gaaagatagg tttgggaggc 6720
gctgtcttgg gagtcgcgac ctttttctgt tggatggctg aagttccagg aacgaagatc 6780
gccggaatgt tgctgctctc ccttctcttg atgattgtgc taattcctga gccagagaag 6840
caacgttcgc agacagacaa ccagctagcc gtgttcctga tttgtgtcat gacccttgtg 6900
agcgcagtgg cagccaacga gatgggttgg ctagataaga ccaagagtga cataagcagt 6960
ttgtttgggc aaagaattga ggtcaaggag aatttcagca tgggagagtt tcttctggac 7020
ttgaggccgg caacagcctg gtcactgtac gctgtgacaa cagcggtcct cactccactg 7080
ctaaagcatt tgatcacgtc agattacatc aacacctcat tgacctcaat aaacgttcag 7140
gcaagtgcac tattcacact cgcgcgaggc ttccccttcg tcgatgttgg agtgtcggct 7200
ctcctgctag cagccggatg ctggggacaa gtcaccctca ccgttacggt aacagcggca 7260
acactccttt tttgccacta tgcctacatg gttcccggtt ggcaagctga ggcaatgcgc 7320
tcagcccagc ggcggacagc ggccggaatc atgaagaacg ctgtagtgga tggcatcgtg 7380
gccacggacg tcccagaatt agagcgcacc acacccatca tgcagaagaa agttggacag 7440
atcatgctga tcttggtgtc tctagctgca gtagtagtga acccgtctgt gaagacagta 7500
cgagaagccg gaattttgat cacggccgca gcggtgacgc tttgggagaa tggagcaagc 7560
tctgtttgga acgcaacaac tgccatcgga ctctgccaca tcatgcgtgg gggttggttg 7620
tcatgtctat ccataacatg gacactcata aagaacatgg aaaaaccagg actaaaaaga 7680
ggtggggcaa aaggacgcac cttgggagag gtttggaaag aaagactcaa ccagatgaca 7740
aaagaagagt tcactaggta ccgcaaagag gccatcatcg aagtcgatcg ctcagcggca 7800
aaacacgcca ggaaagaagg caatgtcact ggagggcatt cagtctctag gggcacagca 7860
aaactgagat ggctggtcga acggaggttt ctcgaaccgg tcggaaaagt gattgacctt 7920
ggatgtggaa gaggcggttg gtgttactat atggcaaccc aaaaaagagt ccaagaagtc 7980
agagggtaca caaagggcgg tcccggacat gaagagcccc aactagtgca aagttatgga 8040
tggaacattg tcaccatgaa gagtggagtg gatgtgttct acagaccttc tgagtgttgt 8100
gacaccctcc tttgtgacat cggagagtcc tcgtcaagtg ctgaggttga agagcatagg 8160
acgattcgtg tccttgaaat ggttgaggac tggctgcacc gagggccaag ggaattttgc 8220
gtgaaggtgc tctgccccta catgccgaaa gtcatagaga agatggagct gctccaacgc 8280
cggtatgggg ggggactggt cagaaaccca ctctcacgga attccacgca cgagatgtat 8340
tgggtgagtc gagcttcagg caatgtggta cattcagtga atatgaccag ccaggtgctc 8400
ctaggaagaa tggaaaaaag gacctggaag ggaccccaat acgaggaaga tgtaaacttg 8460
ggaagtggaa ccagggcggt gggaaaaccc ctgctcaact cagacaccag taaaatcaag 8520
aacaggattg aacgactcag gcgtgagtac agttcgacgt ggcaccacga tgagaaccac 8580
ccatatagaa cctggaacta tcacggcagt tatgatgtga agcccacagg ctccgccagt 8640
tcgctggtca atggagtggt caggctcctc tcaaaaccat gggacaccat cacgaatgtt 8700
accaccatgg ccatgactga cactactccc ttcgggcagc agcgagtgtt caaagagaag 8760
gtggacacga aagctcctga accgccagaa ggagcgaagt acgtgctcaa cgagaccacc 8820
aactggttgt gggcgttttt ggccagagaa aaacgtccca gaatgtgctc tcgagaggaa 8880
ttcataagaa aggtcaacag caatgcagct ttgggtgcca tgtttgaaga gcagaatcaa 8940
tggaggagcg ccagagaagc agttgaagat ccaaaatttt gggagatggt ggatgaggag 9000
cgcgaggcac atctgcgggg ggaatgtcac acttgcattt acaacatgat gggaaagaga 9060
gagaaaaaac ccggagagtt cggaaaggcc aagggaagca gagccatttg gttcatgtgg 9120
ctcggagctc gctttctgga gttcgaggct ctgggttttc tcaatgaaga ccactggctt 9180
ggaagaaaga actcaggagg aggtgtcgag ggcttgggcc tccaaaaact gggttacatc 9240
ctgcgtgaag ttggcacccg gcctgggggc aagatctatg ctgatgacac agctggctgg 9300
gacacccgca tcacgagagc tgacttggaa aatgaagcta aggtgcttga gctgcttgat 9360
ggggaacatc ggcgtcttgc cagggccatc attgagctca cctatcgtca caaagttgtg 9420
aaagtgatgc gcccggctgc tgatggaaga accgtcatgg atgttatctc cagagaagat 9480
cagaggggga gtggacaagt tgtcacctac gccctaaaca ctttcaccaa cctggccgtc 9540
cagctggtga ggatgatgga aggggaagga gtgattggcc cagatgatgt ggagaaactc 9600
acaaaaggga aaggacccaa agtcaggacc tggctgtttg agaatgggga agaaagactc 9660
agccgcatgg ctgtcagtgg agatgactgt gtggtaaagc ccctggacga tcgctttgcc 9720
acctcgctcc acttcctcaa tgctatgtca aaggttcgca aagacatcca agagtggaaa 9780
ccgtcaactg gatggtatga ttggcagcag gttccatttt gctcaaacca tttcactgaa 9840
ttgatcatga aagatggaag aacactggtg gttccatgcc gaggacagga tgaattggta 9900
ggcagagctc gcatatctcc aggggccgga tggaacgtcc gcgacactgc ttgtctggct 9960
aagtcttatg cccagatgtg gctgcttctg tacttccaca gaagagacct gcggctcatg 10020
gccaacgcca tttgctccgc tgtccctgtg aattgggtcc ctaccggaag aaccacgtgg 10080
tccatccatg caggaggaga gtggatgaca acagaggaca tgttggaggt ctggaaccgt 10140
gtttggatag aggagaatga atggatggaa gacaaaaccc cagtggagaa atggagtgac 10200
gtcccatatt caggaaaacg agaggacatc tggtgtggca gcctgattgg cacaagagcc 10260
cgagccacgt gggcagaaaa catccaggtg gctatcaacc aagtcagagc aatcatcgga 10320
gatgagaagt atgtggatta catgagttca ctaaagagat atgaagacac aactttggtt 10380
gaggacacag tactgtagat attaagaaaa ttttgaggag aaagtcaggc cgggaagttc 10440
ccgccaccgg aagttgagta gacggtgctg cctgcgactc aaccccagga ggactgggtg 10500
aacaaagccg cgaagtgatc catgtaagcc ctcagaaccg tctcggaagg aggaccccac 10560
atgttgtaac ttcaaagccc aatgtcagac cacgctacgg cgtgctactc tgcggagagt 10620
gcagtctgcg atagtgcccc aggaggactg ggttaacaaa ggcaaatcaa cgccccacgc 10680
ggccctagcc ccggtaatgg tgttaaccag ggcgaaagga ctagaggtta gaggagaccc 10740
cgcggtttaa agtgcacggc ccagcctggc tgaagctgta ggtcagggga aggactagag 10800
gttagtggag accccgtgcc acaaaacacc acaacaaaac agcatattga cacctgggat 10860
agactaggag atcttctgct ctgcacaacc agccacacgg cacagtgcgc cgacaatggt 10920
ggctggtggt gcgagaacac aggatct 10947
<210> 109
<211> 2219
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 109
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttgtagat atttaatcaa ttgtaaatag acaatataag 1620
tatgcataaa agtgtagttt tatagtagta tttagtggtg ttagtgtaaa tagttaagaa 1680
aattttgagg agaaagtcag gccgggaagt tcccgccacc ggaagttgag tagacggtgc 1740
tgcctgcgac tcaaccccag gaggactggg tgaacaaagc cgcgaagtga tccatgtaag 1800
ccctcagaac cgtctcggaa ggaggacccc acatgttgta acttcaaagc ccaatgtcag 1860
accacgctac ggcgtgctac tctgcggaga gtgcagtctg cgatagtgcc ccaggaggac 1920
tgggttaaca aaggcaaatc aacgccccac gcggccctag ccccggtaat ggtgttaacc 1980
agggcgaaag gactagaggt tagaggagac cccgcggttt aaagtgcacg gcccagcctg 2040
gctgaagctg taggtcaggg gaaggactag aggttagtgg agaccccgtg ccacaaaaca 2100
ccacaacaaa acagcatatt gacacctggg atagactagg agatcttctg ctctgcacaa 2160
ccagccacac ggcacagtgc gccgacaatg gtggctggtg gtgcgagaac acaggatct 2219
<210> 110
<211> 2932
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 110
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc 1620
atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg 1680
ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa 1740
gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact 1800
gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag 1860
ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca 1920
ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt 1980
cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc 2040
aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc 2100
tttggagact catacatagt ggtgggcaga ggagaacaac agattaatca ccattggcac 2160
aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta 2220
gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt 2280
gggaaggctg tccatcaata gatatttaat caattgtaaa tagacaatat aagtatgcat 2340
aaaagtgtag ttttatagta gtatttagtg gtgttagtgt aaatagttaa gaaaattttg 2400
aggagaaagt caggccggga agttcccgcc accggaagtt gagtagacgg tgctgcctgc 2460
gactcaaccc caggaggact gggtgaacaa agccgcgaag tgatccatgt aagccctcag 2520
aaccgtctcg gaaggaggac cccacatgtt gtaacttcaa agcccaatgt cagaccacgc 2580
tacggcgtgc tactctgcgg agagtgcagt ctgcgatagt gccccaggag gactgggtta 2640
acaaaggcaa atcaacgccc cacgcggccc tagccccggt aatggtgtta accagggcga 2700
aaggactaga ggttagagga gaccccgcgg tttaaagtgc acggcccagc ctggctgaag 2760
ctgtaggtca ggggaaggac tagaggttag tggagacccc gtgccacaaa acaccacaac 2820
aaaacagcat attgacacct gggatagact aggagatctt ctgctctgca caaccagcca 2880
cacggcacag tgcgccgaca atggtggctg gtggtgcgag aacacaggat ct 2932
<210> 111
<211> 14195
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 111
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60
gttctctaaa agaactttaa gtcagttctt tattatcaaa acaatgtttt tatgtctgaa 120
gcaaaatgtt ggactgagac tgaccttact aaaggacctc atgaattttg ctctcaacat 180
acaatgctag ttaaacaggg tgatgattat gtgtaccttc cttacccaga tccatcaaga 240
atcctagggg ccggctgttt tgtagatgat atcgtaaaaa cagatggtac acttatgatt 300
gaacggttcg tgtctttagc tatagatgct tacccactta ctaaacatcc taatcaggag 360
tatgctgatg tctttcattt gtacttacaa tacataagaa agctacatga tgagttaaca 420
ggacacatgt tagacatgta ttctgttatg cttactaatg ataacacttc aaggtattgg 480
gaacctgagt tttatgaggc tatgtacaca ccgcatacag tcttacaggc tgttggggct 540
tgtgttcttt gcaattcaca gacttcatta agatgtggtg cttgcatacg tagaccattc 600
ttatgttgta aatgctgtta cgaccatgtc atatcaacat cacataaatt agtcttgtct 660
gttaatccgt atgtttgcaa tgctccaggt tgtgatgtca cagatgtgac tcaactttac 720
ttaggaggta tgagctatta ttgtaaatca cataaaccac ccattagttt tccattgtgt 780
gctaatggac aagtttttgg tttatataaa aatacatgtg ttggtagcga taatgttact 840
gactttaatg caattgcaac atgtgactgg acaaatgctg gtgattacat tttagctaac 900
acctgtactg aaagactcaa gctttttgca gcagaaacgc tcaaagctac tgaggagaca 960
tttaaactgt cttatggtat tgctactgta cgtgaagtgc tgtctgacag agaattacat 1020
ctttcatggg aagttggtaa acctagacca ccacttaacc gaaattatgt ctttactggt 1080
tatcgtgtaa ctaaaaacag taaagtacaa ataggagagt acacctttga aaaaggtgac 1140
tatggtgatg ctgttgttta ccgaggtaca acaacttaca aattaaatgt tggtgattat 1200
tttgtgctga catcacatac agtaatgcca ttaagtgcac ctacactagt gccacaagag 1260
cactatgtta gaattactgg cttataccca acactcaata tctcagatga gttttctagc 1320
aatgttgcaa attatcaaaa ggttggtatg caaaagtatt ctacactcca gggaccacct 1380
ggtactggta agagtcattt tgctattggc ctagctctct actacccttc tgctcgcata 1440
gtgtatacag cttgctctca tgccgctgtt gatgcactat gtgagaaggc attaaaatat 1500
ttgcctatag ataaatgtag tagaattata cctgcacgtg ctcgtgtaga gtgttttgat 1560
aaattcaaag tgaattcaac attagaacag tatgtctttt gtactgtaaa tgcattgcct 1620
gagacgacag cagatatagt tgtctttgat gaaatttcaa tggccacaaa ttatgatttg 1680
agtgttgtca atgccagatt acgtgctaag cactatgtgt acattggcga ccctgctcaa 1740
ttacctgcac cacgcacatt gctaactaag ggcacactag aaccagaata tttcaattca 1800
gtgtgtagac ttatgaaaac tataggtcca gacatgttcc tcggaacttg tcggcgttgt 1860
cctgctgaaa ttgttgacac tgtgagtgct ttggtttatg ataataagct taaagcacat 1920
aaagacaaat cagctcaatg ctttaaaatg ttttataagg gtgttatcac gcatgatgtt 1980
tcatctgcaa ttaacaggcc acaaataggc gtggtaagag aattccttac acgtaaccct 2040
gcttggagaa aagctgtctt tatttcacct tataattcac agaatgctgt agcctcaaag 2100
attttgggac taccaactca aactgttgat tcatcacagg gctcagaata tgactatgtc 2160
atattcactc aaaccactga aacagctcac tcttgtaatg taaacagatt taatgttgct 2220
attaccagag caaaagtagg catactttgc ataatgtctg atagagacct ttatgacaag 2280
ttgcaattta caagtcttga aattccacgt aggaatgtgg caactttaca agctgaaaat 2340
gtaacaggac tctttaaaga ttgtagtaag gtaatcactg ggttacatcc tacacaggca 2400
cctacacacc tcagtgttga cactaaattc aaaactgaag gtttatgtgt tgacatacct 2460
ggcataccta aggacatgac ctatagaaga ctcatctcta tgatgggttt taaaatgaat 2520
tatcaagtta atggttaccc taacatgttt atcacccgcg aagaagctat aagacatgta 2580
cgtgcatgga ttggcttcga tgtcgagggg tgtcatgcta ctagagaagc tgttggtacc 2640
aatttacctt tacagctagg tttttctaca ggtgttaacc tagttgctgt acctacaggt 2700
tatgttgata cacctaataa tacagatttt tccagagtta gtgctaaacc accgcctgga 2760
gatcaattta aacacctcat accacttatg tacaaaggac ttccttggaa tgtagtgcgt 2820
ataaagattg tacaaatgtt aagtgacaca cttaaaaatc tctctgacag agtcgtattt 2880
gtcttatggg cacatggctt tgagttgaca tctatgaagt attttgtgaa aataggacct 2940
gagcgcacct gttgtctatg tgatagacgt gccacatgct tttccactgc ttcagacact 3000
tatgcctgtt ggcatcattc tattggattt gattacgtct ataatccgtt tatgattgat 3060
gttcaacaat ggggttttac aggtaaccta caaagcaacc atgatctgta ttgtcaagtc 3120
catggtaatg cacatgtagc tagttgtgat gcaatcatga ctaggtgtct agctgtccac 3180
gagtgctttg ttaagcgtgt tgactggact attgaatatc ctataattgg tgatgaactg 3240
aagattaatg cggcttgtag aaaggttcaa cacatggttg ttaaagctgc attattagca 3300
gacaaattcc cagttcttca cgacattggt aaccctaaag ctattaagtg tgtacctcaa 3360
gctgatgtag aatggaagtt ctatgatgca cagccttgta gtgacaaagc ttataaaata 3420
gaagaattat tctattctta tgccacacat tctgacaaat tcacagatgg tgtatgccta 3480
ttttggaatt gcaatgtcga tagatatcct gctaattcca ttgtttgtag atttgacact 3540
agagtgctat ctaaccttaa cttgcctggt tgtgatggtg gcagtttgta tgtaaataaa 3600
catgcattcc acacaccagc ttttgataaa agtgcttttg ttaatttaaa acaattacca 3660
tttttctatt actctgacag tccatgtgag tctcatggaa aacaagtagt gtcagatata 3720
gattatgtac cactaaagtc tgctacgtgt ataacacgtt gcaatttagg tggtgctgtc 3780
tgtagacatc atgctaatga gtacagattg tatctcgatg cttataacat gatgatctca 3840
gctggcttta gcttgtgggt ttacaaacaa tttgatactt ataacctctg gaacactttt 3900
acaagacttc agagtttaga aaatgtggct tttaatgttg taaataaggg acactttgat 3960
ggacaacagg gtgaagtacc agtttctatc attaataaca ctgtttacac aaaagttgat 4020
ggtgttgatg tagaattgtt tgaaaataaa acaacattac ctgttaatgt agcatttgag 4080
ctttgggcta agcgcaacat taaaccagta ccagaggtga aaatactcaa taatttgggt 4140
gtggacattg ctgctaatac tgtgatctgg gactacaaaa gagatgctcc agcacatata 4200
tctactattg gtgtttgttc tatgactgac atagccaaga aaccaactga aacgatttgt 4260
gcaccactca ctgtcttttt tgatggtaga gttgatggtc aagtagactt atttagaaat 4320
gcccgtaatg gtgttcttat tacagaaggt agtgttaaag gtttacaacc atctgtaggt 4380
cccaaacaag ctagtcttaa tggagtcaca ttaattggag aagccgtaaa aacacagttc 4440
aattattata agaaagttga tggtgttgtc caacaattac ctgaaactta ctttactcag 4500
agtagaaatt tacaagaatt taaacccagg agtcaaatgg aaattgattt cttagaatta 4560
gctatggatg aattcattga acggtataaa ttagaaggct atgccttcga acatatcgtt 4620
tatggagatt ttagtcatag tcagttaggt ggtttacatc tactgattgg actagctaaa 4680
cgttttaagg aatcaccttt tgaattagaa gattttattc ctatggacag tacagttaaa 4740
aactatttca taacagatgc gcaaacaggt tcatctaagt gtgtgtgttc tgttattgat 4800
ttattacttg atgattttgt tgaaataata aaatcccaag atttatctgt agtttctaag 4860
gttgtcaaag tgactattga ctatacagaa atttcattta tgctttggtg taaagatggc 4920
catgtagaaa cattttaccc aaaattacaa tctagtcaag cgtggcaacc gggtgttgct 4980
atgcctaatc tttacaaaat gcaaagaatg ctattagaaa agtgtgacct tcaaaattat 5040
ggtgatagtg caacattacc taaaggcata atgatgaatg tcgcaaaata tactcaactg 5100
tgtcaatatt taaacacatt aacattagct gtaccctata atatgagagt tatacatttt 5160
ggtgctggtt ctgataaagg agttgcacca ggtacagctg ttttaagaca gtggttgcct 5220
acgggtacgc tgcttgtcga ttcagatctt aatgactttg tctctgatgc agattcaact 5280
ttgattggtg attgtgcaac tgtacataca gctaataaat gggatctcat tattagtgat 5340
atgtacgacc ctaagactaa aaatgttaca aaagaaaatg actctaaaga gggttttttc 5400
acttacattt gtgggtttat acaacaaaag ctagctcttg gaggttccgt ggctataaag 5460
ataacagaac attcttggaa tgctgatctt tataagctca tgggacactt cgcatggtgg 5520
acagcctttg ttactaatgt gaatgcgtca tcatctgaag catttttaat tggatgtaat 5580
tatcttggca aaccacgcga acaaatagat ggttatgtca tgcatgcaaa ttacatattt 5640
tggaggaata caaatccaat tcagttgtct tcctattctt tatttgacat gagtaaattt 5700
ccccttaaat taaggggtac tgctgttatg tctttaaaag aaggtcaaat caatgatatg 5760
attttatctc ttcttagtaa aggtagactt ataattagag aaaacaacag agttgttatt 5820
tctagtgatg ttcttgttaa caactaaacg aacaatgttt gtttttcttg ttttattgcc 5880
actagtctct agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac 5940
taattctttc acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca 6000
ttcaactcag gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca 6060
tgtctctggg accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg 6120
tgtttatttt gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac 6180
tttagattcg aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa 6240
agtctgtgaa tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa 6300
caaaagttgg atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga 6360
atatgtctct cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct 6420
tagggaattt gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc 6480
tattaattta gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt 6540
gccaataggt attaacatca ctaggtttca aactttactt gctttacata gaagttattt 6600
gactcctggt gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta 6660
tcttcaacct aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt 6720
agactgtgca cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga 6780
aaaaggaatc tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt 6840
tcctaatatt acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc 6900
tgtttatgct tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata 6960
taattccgca tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga 7020
tctctgcttt actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca 7080
aatcgctcca gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt 7140
tacaggctgc gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta 7200
taattacctg tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc 7260
aactgaaatc tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta 7320
ctttccttta caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag 7380
agtagtagta ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa 7440
gtctactaat ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac 7500
aggtgttctt actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat 7560
tgctgacact actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc 7620
atgttctttt ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc 7680
tgttctttat caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact 7740
tactcctact tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg 7800
tttaataggg gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg 7860
tatatgcgct agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag 7920
tcaatccatc attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa 7980
taactctatt gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt 8040
gtctatgacc aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg 8100
cagcaatctt ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg 8160
aatagctgtt gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta 8220
caaaacacca ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc 8280
atcaaaacca agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc 8340
agatgctggc ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct 8400
catttgtgca caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat 8460
gattgctcaa tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg 8520
tgcaggtgct gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat 8580
tggagttaca cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag 8640
tgctattggc aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca 8700
agatgtggtc aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa 8760
ttttggtgca atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc 8820
tgaagtgcaa attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac 8880
tcaacaatta attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat 8940
gtcagagtgt gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct 9000
tatgtccttc cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc 9060
tgcacaagaa aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt 9120
tcctcgtgaa ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt 9180
ttatgaacca caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt 9240
aataggaatt gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa 9300
ggaggagtta gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat 9360
ctctggcatt aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt 9420
tgccaagaat ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta 9480
tataaaatgg ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat 9540
ggtgacaatt atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc 9600
ttgtggatcc tgctgcaaat ttgatgaaga cgactctgag ccagtgctca aaggagtcaa 9660
attacattac acataaacga acttatggat ttgtttatga gaatcttcac aattggaact 9720
gtaactttga agcaaggtga aatcaaggat gctactcctt cagattttgt tcgcgctact 9780
gcaacgatac cgatacaagc ctcactccct ttcggatggc ttattgttgg cgttgcactt 9840
cttgctgttt ttcagagcgc ttccaaaatc ataaccctca aaaagagatg gcaactagca 9900
ctctccaagg gtgttcactt tgtttgcaac ttgctgttgt tgtttgtaac agtttactca 9960
caccttttgc tcgttgctgc tggccttgaa gccccttttc tctatcttta tgctttagtc 10020
tacttcttgc agagtataaa ctttgtaaga ataataatga ggctttggct ttgctggaaa 10080
tgccgttcca aaaacccatt actttatgat gccaactatt ttctttgctg gcatactaat 10140
tgttacgact attgtatacc ttacaatagt gtaacttctt caattgtcat tacttcaggt 10200
gatggcacaa caagtcctat ttctgaacat gactaccaga ttggtggtta tactgaaaaa 10260
tgggaatctg gagtaaaaga ctgtgttgta ttacacagtt acttcacttc agactattac 10320
cagctgtact caactcaatt gagtacagac actggtgttg aacatgttac cttcttcatc 10380
tacaataaaa ttgttgatga gcctgaagaa catgtccaaa ttcacacaat cgacggttca 10440
tccggagttg ttaatccagt aatggaacca atttatgatg aaccgacgac gactactagc 10500
gtgcctttgt aagcacaagc tgatgagtac gaacttatgt actcattcgt ttcggaagag 10560
acaggtacgt taatagttaa tagcgtactt ctttttcttg ctttcgtggt attcttgcta 10620
gttacactag ccatccttac tgcgcttcga ttgtgtgcgt actgctgcaa tattgttaac 10680
gtgagtcttg taaaaccttc tttttacgtt tactctcgtg ttaaaaatct gaattcttct 10740
agagttcctg atcttctggt ctaaacgaac taaatattat attagttttt ctgtttggaa 10800
ctttaatttt agccatggca gattccaacg gtactattac cgttgaagag cttaaaaagc 10860
tccttgaaca atggaaccta gtaataggtt tcctattcct tacatggatt tgtcttctac 10920
aatttgccta tgccaacagg aataggtttt tgtatataat taagttaatt ttcctctggc 10980
tgttatggcc agtaacttta gcttgttttg tgcttgctgc tgtttacaga ataaattgga 11040
tcaccggtgg aattgctatc gcaatggctt gtcttgtagg cttgatgtgg ctcagctact 11100
tcattgcttc tttcagactg tttgcgcgta cgcgttccat gtggtcattc aatccagaaa 11160
ctaacattct tctcaacgtg ccactccatg gcactattct gaccagaccg cttctagaaa 11220
gtgaactcgt aatcggagct gtgatccttc gtggacatct tcgtattgct ggacaccatc 11280
taggacgctg tgacatcaag gacctgccta aagaaatcac tgttgctaca tcacgaacgc 11340
tttcttatta caaattggga gcttcgcagc gtgtagcagg tgactcaggt tttgctgcat 11400
acagtcgcta caggattggc aactataaat taaacacaga ccattccagt agcagtgaca 11460
atattgcttt gcttgtacag taagtgacaa cagatgtttc atctcgttga ctttcaggtt 11520
actatagcag agatattact aattattatg aggactttta aagtttccat ttggaatctt 11580
gattacatca taaacctcat aattaaaaat ttatctaagt cactaactga gaataaatat 11640
tctcaattag atgaagagca accaatggag attgattaaa cgaacatgaa aattattctt 11700
ttcttggcac tgataacact cgctacttgt gagctttatc actaccaaga gtgtgttaga 11760
ggtacaacag tacttttaaa agaaccttgc tcttctggaa catacgaggg caattcacca 11820
tttcatcctc tagctgataa caaatttgca ctgacttgct ttagcactca atttgctttt 11880
gcttgtcctg acggcgtaaa acacgtctat cagttacgtg ccagatcagt ttcacctaaa 11940
ctgttcatca gacaagagga agttcaagaa ctttactctc caatttttct tattgttgcg 12000
gcaatagtgt ttataacact ttgcttcaca ctcaaaagaa agacagaatg attgaacttt 12060
cattaattga cttctatttg tgctttttag cctttctgct attccttgtt ttaattatgc 12120
ttattatctt ttggttctca cttgaactgc aagatcataa tgaaacttgt cacgcctaaa 12180
cgaacatgaa atttcttgtt ttcttaggaa tcatcacaac tgtagctgca tttcaccaag 12240
aatgtagttt acagtcatgt actcaacatc aaccatatgt agttgatgac ccgtgtccta 12300
ttcacttcta ttctaaatgg tatattagag taggagctag aaaatcagca cctttaattg 12360
aattgtgcgt ggatgaggct ggttctaaat cacccattca gtacatcgat atcggtaatt 12420
atacagtttc ctgtttacct tttacaatta attgccagga acctaaattg ggtagtcttg 12480
tagtgcgttg ttcgttctat gaagactttt tagagtatca tgacgttcgt gttgttttag 12540
atttcatcta aacgaacaaa ctaaaatgtc tgataatgga ccccaaaatc agcgaaatgc 12600
accccgcatt acgtttggtg gaccctcaga ttcaactggc agtaaccaga atggagaacg 12660
cagtggggcg cgatcaaaac aacgtcggcc ccaaggttta cccaataata ctgcgtcttg 12720
gttcaccgct ctcactcaac atggcaagga agaccttaaa ttccctcgag gacaaggcgt 12780
tccaattaac accaatagca gtccagatga ccaaattggc tactaccgaa gagctaccag 12840
acgaattcgt ggtggtgacg gtaaaatgaa agatctcagt ccaagatggt atttctacta 12900
cctaggaact gggccagaag ctggacttcc ctatggtgct aacaaagacg gcatcatatg 12960
ggttgcaact gagggagcct tgaatacacc aaaagatcac attggcaccc gcaatcctgc 13020
taacaatgct gcaatcgtgc tacaacttcc tcaaggaaca acattgccaa aaggcttcta 13080
cgcagaaggg agcagaggcg gcagtcaagc ctcttctcgt tcctcatcac gtagtcgcaa 13140
cagttcaaga aattcaactc caggcagcag taggggaact tctcctgcta gaatggctgg 13200
caatggcggt gatgctgctc ttgctttgct gctgcttgac agattgaacc agcttgagag 13260
caaaatgtct ggtaaaggcc aacaacaaca aggccaaact gtcactaaga aatctgctgc 13320
tgaggcttct aagaagcctc ggcaaaaacg tactgccact aaagcataca atgtaacaca 13380
agctttcggc agacgtggtc cagaacaaac ccaaggaaat tttggggacc aggaactaat 13440
cagacaagga actgattaca aacattggcc gcaaattgca caatttgccc ccagcgcttc 13500
agcgttcttc ggaatgtcgc gcattggcat ggaagtcaca ccttcgggaa cgtggttgac 13560
ctacacaggt gccatcaaat tggatgacaa agatccaaat ttcaaagatc aagtcatttt 13620
gctgaataag catattgacg catacaaaac attcccacca acagagccta aaaaggacaa 13680
aaagaagaag gctgatgaaa ctcaagcctt accgcagaga cagaagaaac agcaaactgt 13740
gactcttctt cctgctgcag atttggatga tttctccaaa caattgcaac aatccatgag 13800
cagtgctgac tcaactcagg cctaaactca tgcagaccac acaaggcaga tgggctatat 13860
aaacgttttc gcttttccgt ttacgatata tagtctactc ttgtgcagaa tgaattctcg 13920
taactacata gcacaagtag atgtagttaa ctttaatctc acatagcaat ctttaatcag 13980
tgtgtaacat tagggaggac ttgaaagagc caccacattt tcaccgaggc cacgcggagt 14040
acgatcgagt gtacagtgaa caatgctagg gagagctgcc tatatggaag agccctaatg 14100
tgtaaaatta attttagtag tgctatcccc atgtgatttt aatagcttct taggagaatg 14160
acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 14195
<210> 112
<211> 1999
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 112
tcttaatgga gtcacattaa ttggagaagc cgtaaaaaca cagttcaatt attataagaa 60
agttgatggt gttgtccaac aattacctga aacttacttt actcagagta gaaatttaca 120
agaatttaaa cccaggagtc aaatggaaat tgatttctta gaattagcta tggatgaatt 180
cattgaacgg tataaattag aaggctatgc cttcgaacat atcgtttatg gagattttag 240
tcatagtcag ttaggtggtt tacatctact gattggacta gctaaacgtt ttaaggaatc 300
accttttgaa ttagaagatt ttattcctat ggacagtaca gttaaaaact atttcataac 360
agatgcgcaa acaggttcat ctaagtgtgt gtgttctgtt attgatttat tacttgatga 420
ttttgttgaa ataataaaat cccaagattt atctgtagtt tctaaggttg tcaaagtgac 480
tattgactat acagaaattt catttatgct ttggtgtaaa gatggccatg tagaaacatt 540
ttacccaaaa ttacaatcta gtcaagcgtg gcaaccgggt gttgctatgc ctaatcttta 600
caaaatgcaa agaatgctat tagaaaagtg tgaccttcaa aattatggtg atagtgcaac 660
attacctaaa ggcataatga tgaatgtcgc aaaatatact caactgtgtc aatatttaaa 720
cacattaaca ttagctgtac cctataatat gagagttata cattttggtg ctggttctga 780
taaaggagtt gcaccaggta cagctgtttt aagacagtgg ttgcctacgg gtacgctgct 840
tgtcgattca gatcttaatg actttgtctc tgatgcagat tcaactttga ttggtgattg 900
tgcaactgta catacagcta ataaatggga tctcattatt agtgatatgt acgaccctaa 960
gactaaaaat gttacaaaag aaaatgactc taaagagggt tttttcactt acatttgtgg 1020
gtttatacaa caaaagctag ctcttggagg ttccgtggct ataaagataa cagaacattc 1080
ttggaatgct gatctttata agctcatggg acacttcgca tggtggacag cctttgttac 1140
taatgtgaat gcgtcatcat ctgaagcatt tttaattgga tgtaattatc ttggcaaacc 1200
acgcgaacaa atagatggtt atgtcatgca tgcaaattac atattttgga ggaatacaaa 1260
tccaattcag ttgtcttcct attctttatt tgacatgagt aaatttcccc ttaaattaag 1320
gggtactgct gttatgtctt taaaagaagg tcaaatcaat gatatgattt tatctcttct 1380
tagtaaaggt agacttataa ttagagaaaa caacagagtt gttatttcta gtgatgttct 1440
tgttaacaac taaacgaaca atgtttgttt ttcttgtttt attgccacta gtctctagtc 1500
agtgtgttaa tcttacaacc agaactcaat taccccctgc atacactaat tctttcacac 1560
gtggtgttta ttaccctgac aaagttttca gatcctcagt tttacattca actcaggact 1620
tgttcttacc tttcttttcc aatgttactt ggttccatgc tatacatgtc tctgggacca 1680
atggtactaa gaggtttgat aaccctgtcc taccatttaa tgatggtgtt tattttgctt 1740
ccactgagaa gtctaacata ataagaggct ggatttttgg tactacttta gattcgaaga 1800
cccagtccct acttattgtt aataacgcta ctaatgttgt tattaaagtc tgtgaatttc 1860
aattttgtaa tgatccattt ttgggtgttt attaccacaa aaacaacaaa agttggatgg 1920
aaagtgagtt cagagtttat tctagtgcga ataattgcac ttttgaatat gtctctcagc 1980
cttttcttat ggaccttga 1999
<210> 113
<211> 15602
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic sequence
<400> 113
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60
gttctctaaa caaactttaa tgttttattc tctacagtgt tcccacctac aagttttgga 120
ccactagtga gaaaaatatt tgttgatggt gttccatttg tagtttcaac tggataccac 180
ttcagagagc taggtgttgt acataatcag gatgtaaact tacatagctc tagacttagt 240
tttaaggaat tacttgtgta tgctgctgac cctgctatgc acgctgcttc tggtaatcta 300
ttactagata aacgcactac gtgcttttca gtagctgcac ttactaacaa tgttgctttt 360
caaactgtca aacccggtaa ttttaacaaa gacttctatg actttgctgt gtctaagggt 420
ttctttaagg aaggaagttc tgttgaatta aaacacttct tctttgctca ggatggtaat 480
gctgctatca gcgattatga ctactatcgt tataatctac caacaatgtg tgatatcaga 540
caactactat ttgtagttga agttgttgat aagtactttg attgttacga tggtggctgt 600
attaatgcta accaagtcat cgtcaacaac ctagacaaat cagctggttt tccatttaat 660
aaatggggta aggctagact ttattatgat tcaatgagtt atgaggatca agatgcactt 720
ttcgcatata caaaacgtaa tgtcatccct actataactc aaatgaatct taagtatgcc 780
attagtgcaa agaatagagc tcgcaccgta gctggtgtct ctatctgtag tactatgacc 840
aatagacagt ttcatcaaaa attattgaaa tcaatagccg ccactagagg agctactgta 900
gtaattggaa caagcaaatt ctatggtggt tggcacaaca tgttaaaaac tgtttatagt 960
gatgtagaaa accctcacct tatgggttgg gattatccta aatgtgatag agccatgcct 1020
aacatgctta gaattatggc ctcacttgtt cttgctcgca aacatacaac gtgttgtagc 1080
ttgtcacacc gtttctatag attagctaat gagtgtgctc aagtattgag tgaaatggtc 1140
atgtgtggcg gttcactata tgttaaacca ggtggaacct catcaggaga tgccacaact 1200
gcttatgcta atagtgtttt taacatttgt caagctgtca cggccaatgt taatgcactt 1260
ttatctactg atggtaacaa aattgccgat aagtatgtcc gcaatttaca acacagactt 1320
tatgagtgtc tctatagaaa tagagatgtt gacacagact ttgtgaatga gttttacgca 1380
tatttgcgta aacatttctc aatgatgata ctctctgacg atgctgttgt gtgtttcaat 1440
agcacttatg catctcaagg tctagtggct agcataaaga actttaagtc agttctttat 1500
tatcaaaaca atgtttttat gtctgaagca aaatgttgga ctgagactga ccttactaaa 1560
ggacctcatg aattttgctc tcaacataca atgctagtta aacagggtga tgattatgtg 1620
taccttcctt acccagatcc atcaagaatc ctaggggccg gctgttttgt agatgatatc 1680
gtaaaaacag atggtacact tatgattgaa cggttcgtgt ctttagctat agatgcttac 1740
ccacttacta aacatcctaa tcaggagtat gctgatgtct ttcatttgta cttacaatac 1800
ataagaaagc tacatgatga gttaacagga cacatgttag acatgtattc tgttatgctt 1860
actaatgata acacttcaag gtattgggaa cctgagtttt atgaggctat gtacacaccg 1920
catacagtct tacaggctgt tggggcttgt gttctttgca attcacagac ttcattaaga 1980
tgtggtgctt gcatacgtag accattctta tgttgtaaat gctgttacga ccatgtcata 2040
tcaacatcac ataaattagt cttgtctgtt aatccgtatg tttgcaatgc tccaggttgt 2100
gatgtcacag atgtgactca actttactta ggaggtatga gctattattg taaatcacat 2160
aaaccaccca ttagttttcc attgtgtgct aatggacaag tttttggttt atataaaaat 2220
acatgtgttg gtagcgataa tgttactgac tttaatgcaa ttgcaacatg tgactggaca 2280
aatgctggtg attacatttt agctaacacc tgtactgaaa gactcaagct ttttgcagca 2340
gaaacgctca aagctactga ggagacattt aaactgtctt atggtattgc tactgtacgt 2400
gaagtgctgt ctgacagaga attacatctt tcatgggaag ttggtaaacc tagaccacca 2460
cttaaccgaa attatgtctt tactggttat cgtgtaacta aaaacagtaa agtacaaata 2520
ggagagtaca cctttgaaaa aggtgactat ggtgatgctg ttgtttaccg aggtacaaca 2580
acttacaaat taaatgttgg tgattatttt gtgctgacat cacatacagt aatgccatta 2640
agtgcaccta cactagtgcc acaagagcac tatgttagaa ttactggctt atacccaaca 2700
ctcaatatct cagatgagtt ttctagcaat gttgcaaatt atcaaaaggt tggtatgcaa 2760
aagtattcta cactccaggg accacctggt actggtaaga gtcattttgc tattggccta 2820
gctctctact acccttctgc tcgcatagtg tatacagctt gctctcatgc cgctgttgat 2880
gcactatgtg agaaggcatt aaaatatttg cctatagata aatgtagtag aattatacct 2940
gcacgtgctc gtgtagagtg ttttgataaa ttcaaagtga attcaacatt agaacagtat 3000
gtcttttgta ctgtaaatgc attgcctgag acgacagcag atatagttgt ctttgatgaa 3060
atttcaatgg ccacaaatta tgatttgagt gttgtcaatg ccagattacg tgctaagcac 3120
tatgtgtaca ttggcgaccc tgctcaatta cctgcaccac gcacattgct aactaagggc 3180
acactagaac cagaatattt caattcagtg tgtagactta tgaaaactat aggtccagac 3240
atgttcctcg gaacttgtcg gcgttgtcct gctgaaattg ttgacactgt gagtgctttg 3300
gtttatgata ataagcttaa agcacataaa gacaaatcag ctcaatgctt taaaatgttt 3360
tataagggtg ttatcacgca tgatgtttca tctgcaatta acaggccaca aataggcgtg 3420
gtaagagaat tccttacacg taaccctgct tggagaaaag ctgtctttat ttcaccttat 3480
aattcacaga atgctgtagc ctcaaagatt ttgggactac caactcaaac tgttgattca 3540
tcacagggct cagaatatga ctatgtcata ttcactcaaa ccactgaaac agctcactct 3600
tgtaatgtaa acagatttaa tgttgctatt accagagcaa aagtaggcat actttgcata 3660
atgtctgata gagaccttta tgacaagttg caatttacaa gtcttgaaat tccacgtagg 3720
aatgtggcaa ctttacaagc tgaaaatgta acaggactct ttaaagattg tagtaaggta 3780
atcactgggt tacatcctac acaggcacct acacacctca gtgttgacac taaattcaaa 3840
actgaaggtt tatgtgttga catacctggc atacctaagg acatgaccta tagaagactc 3900
atctctatga tgggttttaa aatgaattat caagttaatg gttaccctaa catgtttatc 3960
acccgcgaag aagctataag acatgtacgt gcatggattg gcttcgatgt cgaggggtgt 4020
catgctacta gagaagctgt tggtaccaat ttacctttac agctaggttt ttctacaggt 4080
gttaacctag ttgctgtacc tacaggttat gttgatacac ctaataatac agatttttcc 4140
agagttagtg ctaaaccacc gcctggagat caatttaaac acctcatacc acttatgtac 4200
aaaggacttc cttggaatgt agtgcgtata aagattgtac aaatgttaag tgacacactt 4260
aaaaatctct ctgacagagt cgtatttgtc ttatgggcac atggctttga gttgacatct 4320
atgaagtatt ttgtgaaaat aggacctgag cgcacctgtt gtctatgtga tagacgtgcc 4380
acatgctttt ccactgcttc agacacttat gcctgttggc atcattctat tggatttgat 4440
tacgtctata atccgtttat gattgatgtt caacaatggg gttttacagg taacctacaa 4500
agcaaccatg atctgtattg tcaagtccat ggtaatgcac atgtagctag ttgtgatgca 4560
atcatgacta ggtgtctagc tgtccacgag tgctttgtta agcgtgttga ctggactatt 4620
gaatatccta taattggtga tgaactgaag attaatgcgg cttgtagaaa ggttcaacac 4680
atggttgtta aagctgcatt attagcagac aaattcccag ttcttcacga cattggtaac 4740
cctaaagcta ttaagtgtgt acctcaagct gatgtagaat ggaagttcta tgatgcacag 4800
ccttgtagtg acaaagctta taaaatagaa gaattattct attcttatgc cacacattct 4860
gacaaattca cagatggtgt atgcctattt tggaattgca atgtcgatag atatcctgct 4920
aattccattg tttgtagatt tgacactaga gtgctatcta accttaactt gcctggttgt 4980
gatggtggca gtttgtatgt aaataaacat gcattccaca caccagcttt tgataaaagt 5040
gcttttgtta atttaaaaca attaccattt ttctattact ctgacagtcc atgtgagtct 5100
catggaaaac aagtagtgtc agatatagat tatgtaccac taaagtctgc tacgtgtata 5160
acacgttgca atttaggtgg tgctgtctgt agacatcatg ctaatgagta cagattgtat 5220
ctcgatgctt ataacatgat gatctcagct ggctttagct tgtgggttta caaacaattt 5280
gatacttata acctctggaa cacttttaca agacttcaga gtttagaaaa tgtggctttt 5340
aatgttgtaa ataagggaca ctttgatgga caacagggtg aagtaccagt ttctatcatt 5400
aataacactg tttacacaaa agttgatggt gttgatgtag aattgtttga aaataaaaca 5460
acattacctg ttaatgtagc atttgagctt tgggctaagc gcaacattaa accagtacca 5520
gaggtgaaaa tactcaataa tttgggtgtg gacattgctg ctaatactgt gatctgggac 5580
tacaaaagag atgctccagc acatatatct actattggtg tttgttctat gactgacata 5640
gccaagaaac caactgaaac gatttgtgca ccactcactg tcttttttga tggtagagtt 5700
gatggtcaag tagacttatt tagaaatgcc cgtaatggtg ttcttattac agaaggtagt 5760
gttaaaggtt tacaaccatc tgtaggtccc aaacaagcta gtcttaatgg agtcacatta 5820
attggagaag ccgtaaaaac acagttcaat tattataaga aagttgatgg tgttgtccaa 5880
caattacctg aaacttactt tactcagagt agaaatttac aagaatttaa acccaggagt 5940
caaatggaaa ttgatttctt agaattagct atggatgaat tcattgaacg gtataaatta 6000
gaaggctatg ccttcgaaca tatcgtttat ggagatttta gtcatagtca gttaggtggt 6060
ttacatctac tgattggact agctaaacgt tttaaggaat caccttttga attagaagat 6120
tttattccta tggacagtac agttaaaaac tatttcataa cagatgcgca aacaggttca 6180
tctaagtgtg tgtgttctgt tattgattta ttacttgatg attttgttga aataataaaa 6240
tcccaagatt tatctgtagt ttctaaggtt gtcaaagtga ctattgacta tacagaaatt 6300
tcatttatgc tttggtgtaa agatggccat gtagaaacat tttacccaaa attacaatct 6360
agtcaagcgt ggcaaccggg tgttgctatg cctaatcttt acaaaatgca aagaatgcta 6420
ttagaaaagt gtgaccttca aaattatggt gatagtgcaa cattacctaa aggcataatg 6480
atgaatgtcg caaaatatac tcaactgtgt caatatttaa acacattaac attagctgta 6540
ccctataata tgagagttat acattttggt gctggttctg ataaaggagt tgcaccaggt 6600
acagctgttt taagacagtg gttgcctacg ggtacgctgc ttgtcgattc agatcttaat 6660
gactttgtct ctgatgcaga ttcaactttg attggtgatt gtgcaactgt acatacagct 6720
aataaatggg atctcattat tagtgatatg tacgacccta agactaaaaa tgttacaaaa 6780
gaaaatgact ctaaagaggg ttttttcact tacatttgtg ggtttataca acaaaagcta 6840
gctcttggag gttccgtggc tataaagata acagaacatt cttggaatgc tgatctttat 6900
aagctcatgg gacacttcgc atggtggaca gcctttgtta ctaatgtgaa tgcgtcatca 6960
tctgaagcat ttttaattgg atgtaattat cttggcaaac cacgcgaaca aatagatggt 7020
tatgtcatgc atgcaaatta catattttgg aggaatacaa atccaattca gttgtcttcc 7080
tattctttat ttgacatgag taaatttccc cttaaattaa ggggtactgc tgttatgtct 7140
ttaaaagaag gtcaaatcaa tgatatgatt ttatctcttc ttagtaaagg tagacttata 7200
attagagaaa acaacagagt tgttatttct agtgatgttc ttgttaacaa ctaaacgaac 7260
aatgtttgtt tttcttgttt tattgccact agtctctagt cagtgtgtta atcttacaac 7320
cagaactcaa ttaccccctg catacactaa ttctttcaca cgtggtgttt attaccctga 7380
caaagttttc agatcctcag ttttacattc aactcaggac ttgttcttac ctttcttttc 7440
caatgttact tggttccatg ctatacatgt ctctgggacc aatggtacta agaggtttga 7500
taaccctgtc ctaccattta atgatggtgt ttattttgct tccactgaga agtctaacat 7560
aataagaggc tggatttttg gtactacttt agattcgaag acccagtccc tacttattgt 7620
taataacgct actaatgttg ttattaaagt ctgtgaattt caattttgta atgatccatt 7680
tttgggtgtt tattaccaca aaaacaacaa aagttggatg gaaagtgagt tcagagttta 7740
ttctagtgcg aataattgca cttttgaata tgtctctcag ccttttctta tggaccttga 7800
aggaaaacag ggtaatttca aaaatcttag ggaatttgtg tttaagaata ttgatggtta 7860
ttttaaaata tattctaagc acacgcctat taatttagtg cgtgatctcc ctcagggttt 7920
ttcggcttta gaaccattgg tagatttgcc aataggtatt aacatcacta ggtttcaaac 7980
tttacttgct ttacatagaa gttatttgac tcctggtgat tcttcttcag gttggacagc 8040
tggtgctgca gcttattatg tgggttatct tcaacctagg acttttctat taaaatataa 8100
tgaaaatgga accattacag atgctgtaga ctgtgcactt gaccctctct cagaaacaaa 8160
gtgtacgttg aaatccttca ctgtagaaaa aggaatctat caaacttcta actttagagt 8220
ccaaccaaca gaatctattg ttagatttcc taatattaca aacttgtgcc cttttggtga 8280
agtttttaac gccaccagat ttgcatctgt ttatgcttgg aacaggaaga gaatcagcaa 8340
ctgtgttgct gattattctg tcctatataa ttccgcatca ttttccactt ttaagtgtta 8400
tggagtgtct cctactaaat taaatgatct ctgctttact aatgtctatg cagattcatt 8460
tgtaattaga ggtgatgaag tcagacaaat cgctccaggg caaactggaa agattgctga 8520
ttataattat aaattaccag atgattttac aggctgcgtt atagcttgga attctaacaa 8580
tcttgattct aaggttggtg gtaattataa ttacctgtat agattgttta ggaagtctaa 8640
tctcaaacct tttgagagag atatttcaac tgaaatctat caggccggta gcacaccttg 8700
taatggtgtt gaaggtttta attgttactt tcctttacaa tcatatggtt tccaacccac 8760
taatggtgtt ggttaccaac catacagagt agtagtactt tcttttgaac ttctacatgc 8820
accagcaact gtttgtggac ctaaaaagtc tactaatttg gttaaaaaca aatgtgtcaa 8880
tttcaacttc aatggtttaa caggcacagg tgttcttact gagtctaaca aaaagtttct 8940
gcctttccaa caatttggca gagacattgc tgacactact gatgctgtcc gtgatccaca 9000
gacacttgag attcttgaca ttacaccatg ttcttttggt ggtgtcagtg ttataacacc 9060
aggaacaaat acttctaacc aggttgctgt tctttatcag gatgttaact gcacagaagt 9120
ccctgttgct attcatgcag atcaacttac tcctacttgg cgtgtttatt ctacaggttc 9180
taatgttttt caaacacgtg caggctgttt aataggggct gaacatgtca acaactcata 9240
tgagtgtgac atacccattg gtgcaggtat atgcgctagt tatcagactc agactaattc 9300
tcctcggcgg gcacgtagtg tagctagtca atccatcatt gcctacacta tgtcacttgg 9360
tgcagaaaat tcagttgctt actctaataa ctctattgcc atacccacaa attttactat 9420
tagtgttacc acagaaattc taccagtgtc tatgaccaag acatcagtag attgtacaat 9480
gtacatttgt ggtgattcaa ctgaatgcag caatcttttg ttgcaatatg gcagtttttg 9540
tacacaatta aaccgtgctt taactggaat agctgttgaa caagacaaaa acacccaaga 9600
agtttttgca caagtcaaac aaatttacaa aacaccacca attaaagatt ttggtggttt 9660
taatttttca caaatattac cagatccatc aaaaccaagc aagaggtcat ttattgaaga 9720
tctacttttc aacaaagtga cacttgcaga tgctggcttc atcaaacaat atggtgattg 9780
ccttggtgat attgctgcta gagacctcat ttgtgcacaa aagtttaacg gccttactgt 9840
tttgccacct ttgctcacag atgaaatgat tgctcaatac acttctgcac tgttagcggg 9900
tacaatcact tctggttgga cctttggtgc aggtgctgca ttacaaatac catttgctat 9960
gcaaatggct tataggttta atggtattgg agttacacag aatgttctct atgagaacca 10020
aaaattgatt gccaaccaat ttaatagtgc tattggcaaa attcaagact cactttcttc 10080
cacagcaagt gcacttggaa aacttcaaga tgtggtcaac caaaatgcac aagctttaaa 10140
cacgcttgtt aaacaactta gctccaattt tggtgcaatt tcaagtgttt taaatgatat 10200
cctttcacgt cttgacaaag ttgaggctga agtgcaaatt gataggttga tcacaggcag 10260
acttcaaagt ttgcagacat atgtgactca acaattaatt agagctgcag aaatcagagc 10320
ttctgctaat cttgctgcta ctaaaatgtc agagtgtgta cttggacaat caaaaagagt 10380
tgatttttgt ggaaagggct atcatcttat gtccttccct cagtcagcac ctcatggtgt 10440
agtcttcttg catgtgactt atgtccctgc acaagaaaag aacttcacaa ctgctcctgc 10500
catttgtcat gatggaaaag cacactttcc tcgtgaaggt gtctttgttt caaatggcac 10560
acactggttt gtaacacaaa ggaattttta tgaaccacaa atcattacta cagacaacac 10620
atttgtgtct ggtaactgtg atgttgtaat aggaattgtc aacaacacag tttatgatcc 10680
tttgcaacct gaattagact cattcaagga ggagttagat aaatatttta agaatcatac 10740
atcaccagat gttgatttag gtgacatctc tggcattaat gcttcagttg taaacattca 10800
aaaagaaatt gaccgcctca atgaggttgc caagaattta aatgaatctc tcatcgatct 10860
ccaagaactt ggaaagtatg agcagtatat aaaatggcca tggtacattt ggctaggttt 10920
tatagctggc ttgattgcca tagtaatggt gacaattatg ctttgctgta tgaccagttg 10980
ctgtagttgt ctcaagggct gttgttcttg tggatcctgc tgcaaatttg atgaagacga 11040
ctctgagcca gtgctcaaag gagtcaaatt acattacaca taaacgaact tatggatttg 11100
tttatgagaa tcttcacaat tggaactgta actttgaagc aaggtgaaat caaggatgct 11160
actccttcag attttgttcg cgctactgca acgataccga tacaagcctc actccctttc 11220
ggatggctta ttgttggcgt tgcacttctt gctgtttttc agagcgcttc caaaatcata 11280
accctcaaaa agagatggca actagcactc tccaagggtg ttcactttgt ttgcaacttg 11340
ctgttgttgt ttgtaacagt ttactcacac cttttgctcg ttgctgctgg ccttgaagcc 11400
ccttttctct atctttatgc tttagtctac ttcttgcaga gtataaactt tgtaagaata 11460
ataatgaggc tttggctttg ctggaaatgc cgttccaaaa acccattact ttatgatgcc 11520
aactattttc tttgctggca tactaattgt tacgactatt gtatacctta caatagtgta 11580
acttcttcaa ttgtcattac ttcaggtgat ggcacaacaa gtcctatttc tgaacatgac 11640
taccagattg gtggttatac tgaaaaatgg gaatctggag taaaagactg tgttgtatta 11700
cacagttact tcacttcaga ctattaccag ctgtactcaa ctcaattgag tacagacact 11760
ggtgttgaac atgttacctt cttcatctac aataaaattg ttgatgagcc tgaagaacat 11820
gtccaaattc acacaatcga cggttcatcc ggagttgtta atccagtaat ggaaccaatt 11880
tatgatgaac cgacgacgac tactagcgtg cctttgtaag cacaagctga tgagtacgaa 11940
cttatgtact cattcgtttc ggaagagaca ggtacgttaa tagttaatag cgtacttctt 12000
tttcttgctt tcgtggtatt cttgctagtt acactagcca tccttactgc gcttcgattg 12060
tgtgcgtact gctgcaatat tgttaacgtg agtcttgtaa aaccttcttt ttacgtttac 12120
tctcgtgtta aaaatctgaa ttcttctaga gttcctgatc ttctggtcta aacgaactaa 12180
atattatatt agtttttctg tttggaactt taattttagc catggcagat tccaacggta 12240
ctattaccgt tgaagagctt aaaaagctcc ttgaacaatg gaacctagta ataggtttcc 12300
tattccttac atggatttgt cttctacaat ttgcctatgc caacaggaat aggtttttgt 12360
atataattaa gttaattttc ctctggctgt tatggccagt aactttagct tgttttgtgc 12420
ttgctgctgt ttacagaata aattggatca ccggtggaat tgctatcgca atggcttgtc 12480
ttgtaggctt gatgtggctc agctacttca ttgcttcttt cagactgttt gcgcgtacgc 12540
gttccatgtg gtcattcaat ccagaaacta acattcttct caacgtgcca ctccatggca 12600
ctattctgac cagaccgctt ctagaaagtg aactcgtaat cggagctgtg atccttcgtg 12660
gacatcttcg tattgctgga caccatctag gacgctgtga catcaaggac ctgcctaaag 12720
aaatcactgt tgctacatca cgaacgcttt cttattacaa attgggagct tcgcagcgtg 12780
tagcaggtga ctcaggtttt gctgcataca gtcgctacag gattggcaac tataaattaa 12840
acacagacca ttccagtagc agtgacaata ttgctttgct tgtacagtaa gtgacaacag 12900
atgtttcatc tcgttgactt tcaggttact atagcagaga tattactaat tattatgagg 12960
acttttaaag tttccatttg gaatcttgat tacatcataa acctcataat taaaaattta 13020
tctaagtcac taactgagaa taaatattct caattagatg aagagcaacc aatggagatt 13080
gattaaacga acatgaaaat tattcttttc ttggcactga taacactcgc tacttgtgag 13140
ctttatcact accaagagtg tgttagaggt acaacagtac ttttaaaaga accttgctct 13200
tctggaacat acgagggcaa ttcaccattt catcctctag ctgataacaa atttgcactg 13260
acttgcttta gcactcaatt tgcttttgct tgtcctgacg gcgtaaaaca cgtctatcag 13320
ttacgtgcca gatcagtttc acctaaactg ttcatcagac aagaggaagt tcaagaactt 13380
tactctccaa tttttcttat tgttgcggca atagtgttta taacactttg cttcacactc 13440
aaaagaaaga cagaatgatt gaactttcat taattgactt ctatttgtgc tttttagcct 13500
ttctgctatt ccttgtttta attatgctta ttatcttttg gttctcactt gaactgcaag 13560
atcataatga aacttgtcac gcctaaacga acatgaaatt tcttgttttc ttaggaatca 13620
tcacaactgt agctgcattt caccaagaat gtagtttaca gtcatgtact caacatcaac 13680
catatgtagt tgatgacccg tgtcctattc acttctattc taaatggtat attagagtag 13740
gagctagaaa atcagcacct ttaattgaat tgtgcgtgga tgaggctggt tctaaatcac 13800
ccattcagta catcgatatc ggtaattata cagtttcctg tttacctttt acaattaatt 13860
gccaggaacc taaattgggt agtcttgtag tgcgttgttc gttctatgaa gactttttag 13920
agtatcatga cgttcgtgtt gttttagatt tcatctaaac gaacaaacta aaatgtctga 13980
taatggaccc caaaatcagc gaaatgcacc ccgcattacg tttggtggac cctcagattc 14040
aactggcagt aaccagaatg gagaacgcag tggggcgcga tcaaaacaac gtcggcccca 14100
aggtttaccc aataatactg cgtcttggtt caccgctctc actcaacatg gcaaggaaga 14160
ccttaaattc cctcgaggac aaggcgttcc aattaacacc aatagcagtc cagatgacca 14220
aattggctac taccgaagag ctaccagacg aattcgtggt ggtgacggta aaatgaaaga 14280
tctcagtcca agatggtatt tctactacct aggaactggg ccagaagctg gacttcccta 14340
tggtgctaac aaagacggca tcatatgggt tgcaactgag ggagccttga atacaccaaa 14400
agatcacatt ggcacccgca atcctgctaa caatgctgca atcgtgctac aacttcctca 14460
aggaacaaca ttgccaaaag gcttctacgc agaagggagc agaggcggca gtcaagcctc 14520
ttctcgttcc tcatcacgta gtcgcaacag ttcaagaaat tcaactccag gcagcagtag 14580
gggaacttct cctgctagaa tggctggcaa tggcggtgat gctgctcttg ctttgctgct 14640
gcttgacaga ttgaaccagc ttgagagcaa aatgtctggt aaaggccaac aacaacaagg 14700
ccaaactgtc actaagaaat ctgctgctga ggcttctaag aagcctcggc aaaaacgtac 14760
tgccactaaa gcatacaatg taacacaagc tttcggcaga cgtggtccag aacaaaccca 14820
aggaaatttt ggggaccagg aactaatcag acaaggaact gattacaaac attggccgca 14880
aattgcacaa tttgccccca gcgcttcagc gttcttcgga atgtcgcgca ttggcatgga 14940
agtcacacct tcgggaacgt ggttgaccta cacaggtgcc atcaaattgg atgacaaaga 15000
tccaaatttc aaagatcaag tcattttgct gaataagcat attgacgcat acaaaacatt 15060
cccaccaaca gagcctaaaa aggacaaaaa gaagaaggct gatgaaactc aagccttacc 15120
gcagagacag aagaaacagc aaactgtgac tcttcttcct gctgcagatt tggatgattt 15180
ctccaaacaa ttgcaacaat ccatgagcag tgctgactca actcaggcct aaactcatgc 15240
agaccacaca aggcagatgg gctatataaa cgttttcgct tttccgttta cgatatatag 15300
tctactcttg tgcagaatga attctcgtaa ctacatagca caagtagatg tagttaactt 15360
taatctcaca tagcaatctt taatcagtgt gtaacattag ggaggacttg aaagagccac 15420
cacattttca ccgaggccac gcggagtacg atcgagtgta cagtgaacaa tgctagggag 15480
agctgcctat atggaagagc cctaatgtgt aaaattaatt ttagtagtgc tatccccatg 15540
tgattttaat agcttcttag gagaatgaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 15600
aa 15602
Claims (51)
- 결함이 있는 간섭 바이러스 게놈(DVG)을 생성하는 방법으로서,
높은 감염 다중도(MOI)로 기준 감염성 바이러스에 감염된 세포 및 고체 지지체를 포함하는 적어도 3개의 복제 시험관내 세포 배양물의 제1 세트를 제공하는 단계;
낮은 감염 다중도(MOI)로 기준 감염성 바이러스에 감염된 세포 및 고체 지지체를 포함하는 적어도 3개의 복제 시험관내 세포 배양물의 제2 세트를 제공하는 단계;
상기 복제 시험관내 세포 배양물의 제1 및 제2 세트를 돌연변이 유발 조건 하에서 적어도 5회 계대 배양하는 단계;
상기 시험관내 복제 세포 배양물의 제1 및 제2 세트의 배지로부터 복수의 DVG 후보를 수집하는 단계;
상기 수집된 DVG 후보를 심층 시퀀싱하는 단계;
상기 복수의 DVG 후보로부터 DVG를 선택하는 단계;를 포함하는, 방법. - 제 1 항에 있어서,
높은 감염 다중도(MOI)로 기준 감염성 바이러스에 감염된 세포 및 고체 지지체를 포함하는, 적어도 3개의 복제 시험관내 세포 배양물의 제3 세트를 제공하는 단계; 및/또는
낮은 감염 다중도(MOI)로 기준 감염성 바이러스에 감염된 세포 및 고체 지지체를 포함하는, 적어도 3개의 복제 시험관내 세포 배양물의 제4 세트를 제공하는 단계; 및
복제 시험관내 세포 배양물의 제3 및/또는 제4 세트를 비돌연변이유발 조건 하에서 적어도 5회 계대 배양하는 단계;를 더 포함하는, 방법. - 제 1 항 또는 제 2 항에 있어서,
복수의 DVG 후보로부터 DVG를 선택하는 단계는:
DVG 후보의 서열을 기준 감염성 바이러스의 게놈의 서열과 비교하는 단계;
결실 또는 재배열인 적어도 하나의 스플라이싱 이벤트(splicing event)를 포함하는 게놈을 갖는 적어도 하나의 DVG 후보를 확인하는 단계;
시퀀싱된 DVG 후보 게놈의 집단 중에서 적어도 하나의 스플라이싱 이벤트를 갖는 게놈을 갖는 적어도 하나의 DVG 후보의 상대 빈도를 결정하는 단계; 및
적어도 하나의 DVG를 선택하는 단계로서,
a) 적어도 하나의 스플라이싱 이벤트는 낮은 MOI의 배양물에서보다 높은 MOI의 배양물에서 더 풍부하고; 및/또는
b) 적어도 하나의 스플라이싱 이벤트는 적어도 2, 3, 4, 5, 6, 7, 8 또는 9개의 서로 다른 세포주에서 나타나고; 및/또는
c) 적어도 하나의 스플라이싱 이벤트는 적어도 5, 10, 15 또는 20회의 계대 후에, 적어도 12, 24 또는 36개의 독립적인 복제물 중 적어도 3개에서 확인되고; 및/또는
d) 적어도 하나의 스플라이싱 이벤트는 결실 이벤트이고 그 결실의 뉴클레오티드 크기는 적어도 40, 42, 50, 100, 150, 200, 400, 600 또는 1000개의 뉴클레오티드이고; 및/또는
e) DVG의 오픈 리딩 프레임이 유지되고; 및/또는
f) 바이러스 복제에 필요한 구조적 도메인 및 기능은 DVG에서 유지되고; 및/또는
g) DVG는 기준 감염성 바이러스의 자가 복제 능력을 감소시키는 적어도 하나의 돌연변이를 포함하는, DVG를 선택하는 단계;
를 포함하는, 방법. - 제 1 항 내지 제 3 항 중 어느 한 항에 있어서,
DVG는 기준 감염성 바이러스에 대해 적어도 50%, 60%, 70%, 80% 또는 90%의 시험관내 억제 활성에 의해 특성화되는, 방법. - 제 1 항 내지 제 4 항 중 어느 한 항에 있어서,
상기 기준 감염성 바이러스는 돌연변이 유발 유전자 표현형(mutator phenotype)을 갖는, 방법. - 제 1 항 내지 제 5 항 중 어느 한 항에 있어서,
상기 기준 감염성 바이러스는, 치쿤구니야 바이러스(CHIKV), 지카 바이러스(ZIKV), 엔테로바이러스 71(EV71), 리노바이러스(RV), 황열병 바이러스(YFV), 웨스트 나일 바이러스(WNV), 또는 코로나바이러스(CV)인, 방법. - 제 1 항 내지 제 5 항 중 어느 한 항에 있어서,
상기 기준 감염성 바이러스는: CHIKV 인도양 계통(GenBank 수탁 번호 AM258994), CHIKV 카리브해 균주(GenBank 수탁 번호 LN898104.1), ZIKV 아프리카 균주 MR766(KY989511.1), EV71 Sep006(GenBank 수탁 번호 KX197462.1), RV-A01a(NC_038311.1), RV-A16 (L24917.1), RV-B14 (L05355.1), RV-C15 (GU219984.1), 웨스트 나일 바이러스 이스라엘 1998 및 YFV 균주, 황열 바이러스 아시비(YF-아시비) 균주, 황열 바이러스 백신(YF-17D) 균주, 및 코로나바이러스 SARS-CoV-2 균주로 이루어진 군으로부터 선택되는, 방법. - 제 1 항 내지 제 7 항 중 어느 한 항에 있어서,
상기 세포는: 아프리카 녹색 원숭이 신장 세포에서 유래된 세포주(선택적으로 Vero, 선택적으로 Vero-E6 세포주), 인간 근육에서 유래된 세포주(선택적으로 RD 세포주), 아기 햄스터 신장에서 유래된 세포주(선택적으로 BHK 세포주), 인간 배아 신장 세포로부터 유래된 세포주(선택적으로 HEK293T 세포주), 간암 세포로부터 유래된 세포주(선택적으로 Huh7 세포주), 및 자궁경부 선암종으로부터 유래된 세포주(선택적으로 H1-HeLa, 선택적으로 HeLa-E8 세포주)로 이루어지는 군으로부터 선택된 포유동물 세포주인, 방법. - 제 1 항 내지 제 7 항 중 어느 한 항에 있어서,
상기 세포는: 이집트숲모기(Aedes aegypti)에서 유래된 세포주(선택적으로 Aag2 세포주), 흰줄숲모기(Aedes albopictus)에서 유래된 세포(선택적으로 C6/36 세포주) 및 흰줄숲모기에서 유래된 세포주(선택적으로 U4.4 세포주)로 이루어지는 군으로부터 선택된 모기 세포주인, 방법. - 제 1 항 내지 제 9 항 중 어느 한 항에 있어서,
감염에 대한 낮은 MOI는 0.001 내지 0.1 PFU/세포, 특히 0.01 내지 0.1 PFU/세포인, 방법. - 제 1 항 내지 제 10 항 중 어느 한 항에 있어서,
감염에 대한 높은 MOI는 1 내지 100 PFU/세포, 특히 5 내지 50 PFU/세포 또는 5 내지 20 PFU/세포인, 방법. - 제 1 항 내지 제 11 항 중 어느 한 항에 따른 방법에 의해 생성된 DVG.
- 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201), 서열 번호: 21 (DG21: EV71 DVG 7238-7292), 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K), 서열 번호: 33 (ZIKV DVG-L), 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3), 서열 번호: 53 (CHIKV DVG-CA4), 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 92 (RV DVG C15-TIP-04), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19), 서열 번호: 87 (RV DVG B14-TIP-20), 서열 번호:93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K), 서열 번호: 104 (YFV DVG-L), 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5), 서열 번호: 110 (WNV DVG-6), 서열 번호: 111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는 DVG.
- 제 12 항 또는 제 13 항의 DVG를 포함하는 결함이 있는(defective) 간섭 입자.
- 대상체에서 바이러스 감염을 치료하는 방법으로서, 제 12 항 내지 제 14 항 중 어느 한 항에 따른 적어도 하나의 DVG 또는 결함이 있는 간섭 입자를 효과적인 치료량으로 투여하는 것을 포함하는, 방법.
- 제 15 항에 있어서,
DVG는 네이키드 RNA로서 투여되는, 방법. - 제 15 항에 있어서,
적어도 하나의 DVG는 결함이 있는 간섭 CHIKV 게놈인, 방법. - 제 17 항에 있어서,
적어도 하나의 결함이 있는 간섭 CHIKV 게놈은: 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3) 및 서열 번호: 53 (CHIKV DVG-CA4)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 방법. - 제 15 항에 있어서,
적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 ZIKV 게놈인, 방법. - 제 19 항에 있어서,
적어도 하나의 간섭 ZIKV 게놈은: 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K) 및 서열 번호: 33 (ZIKV DVG-L), 특히 서열 번호: 32 (ZIKV DVG-K)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 방법. - 제 15 항에 있어서,
적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 EV71 게놈인, 방법. - 제 21 항에 있어서,
적어도 하나의 결함이 있는 간섭 EV71 게놈은: 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201) 및 서열 번호: 21 (DG21: EV71 DVG 7238-7292)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 방법. - 제 15 항에 있어서,
적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 RV 게놈인, 방법. - 제 23 항에 있어서,
적어도 하나의 결함이 있는 간섭 RV 게놈은: 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 92 (RV DVG C15-TIP-04), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19) 및 서열 번호: 87 (RV DVG B14-TIP-20)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 방법. - 제 15 항에 있어서,
적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 YFV 게놈인, 방법. - 제 25 항에 있어서,
적어도 하나의 간섭 YFV 게놈은: 서열 번호: 93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K) 및 서열 번호: 104 (YFV DVG-L)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 방법. - 제 15 항에 있어서,
적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 WNV 게놈인, 방법. - 제 27 항에 있어서,
적어도 하나의 간섭 WNV 게놈은: 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5) 및 서열 번호: 110 (WNV DVG-6)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 방법. - 제 15 항에 있어서,
적어도 하나의 결함이 있는 간섭 게놈은 결함이 있는 간섭 CV 게놈인, 방법. - 제 29 항에 있어서,
적어도 하나의 결함이 있는 간섭 CV 게놈은: 서열 번호: 111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 방법. - 대상체에 대한 CHIKV 감염의 치료 방법에 사용하기 위한 제 12 항 내지 제 14 항 중 어느 한 항에 따른 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자로서, 특히 결함이 있는 간섭 게놈은: 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3) 및 서열 번호: 53 (CHIKV DVG-CA4)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자.
- 대상체에 대한 ZIKV 감염의 치료 방법에 사용하기 위한 제 12 항 내지 제 14 항 중 어느 한 항에 따른 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자로서, 특히 결함이 있는 간섭 게놈은: 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K) 및 서열 번호: 33 (ZIKV DVG-L)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자.
- 대상체에 대한 EV71 감염의 치료 방법에 사용하기 위한 제 12 항 내지 제 14 항 중 어느 한 항에 따른 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자로서, 특히 결함이 있는 간섭 게놈은: 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201) 및 서열 번호: 21 (DG21: EV71 DVG 7238-7292)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자.
- 대상체에 대한 RV 감염의 치료 방법에 사용하기 위한 제 12 항 내지 제 14 항 중 어느 한 항에 따른 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자로서, 특히 결함이 있는 간섭 게놈은: 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 92 (RV DVG C15-TIP-04), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19) 및 서열 번호: 87 (RV DVG B14-TIP-20)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자.
- 대상체에 대한 YFV 감염의 치료 방법에 사용하기 위한 제 12 항 내지 제 14 항 중 어느 한 항에 따른 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자로서, 특히 결함이 있는 간섭 게놈은: 서열 번호: 93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K) 및 서열 번호: 104 (YFV DVG-L)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자.
- 대상체에 대한 WNV 감염의 치료 방법에 사용하기 위한 제 12 항 내지 제 14 항 중 어느 한 항에 따른 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자로서, 특히 결함이 있는 간섭 게놈은: 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5) 및 서열 번호: 110 (WNV DVG-6)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자.
- 대상체에 대한 CV 감염, 특히 대상체에 대한 SARS-CoV-2 감염의 치료 방법에 사용하기 위한 제 12 항 내지 제 14 항 중 어느 한 항에 따른 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자로서, 특히 결함이 있는 간섭 게놈은: 서열 번호: 111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 결함이 있는 간섭 게놈 DVG 또는 결함이 있는 간섭 입자.
- 제 12 항 또는 제 13 항에 따른 적어도 하나의 DVG, 및 약학적으로 허용가능한 담체를 포함하는, 약학적, 면역원성, 또는 치료적 조성물.
- 제 14 항에 따른 적어도 하나의 결함이 있는 간섭 입자, 및 약학적으로 허용가능한 담체를 포함하는, 약학적, 면역원성, 또는 치료적 조성물.
- 제 38 항 또는 제 39 항에 따른 조성물을 포함하는 백신.
- DVG 또는 결함이 간섭 입자의 표적 바이러스에 감염된 환자의 치료를 위한 약물의 제조를 위한, 제 12 항 또는 제 13 항에 따른 DVG 또는 제 14 항에 따른 결함이 있는 간섭 입자의 용도.
- CHIKV에 감염된 환자의 치료를 위한 약물의 제조를 위한, 제 12 항 또는 제 13 항에 따른 DVG 또는 제 14 항에 따른 결함이 있는 간섭 입자의 용도.
- ZIKV에 감염된 환자의 치료를 위한 약물의 제조를 위한, 제 12 항 또는 제 13 항에 따른 DVG 또는 제 14 항에 따른 결함이 있는 간섭 입자의 용도.
- EV71에 감염된 환자의 치료를 위한 약물의 제조를 위한, 제 12 항 또는 제 13 항에 따른 DVG 또는 제 14 항에 따른 결함이 있는 간섭 입자의 용도.
- RV에 감염된 환자의 치료를 위한 약물의 제조를 위한, 제 12 항 또는 제 13 항에 따른 DVG 또는 제 14 항에 따른 결함이 있는 간섭 입자의 용도.
- YFV에 감염된 환자의 치료를 위한 약물의 제조를 위한, 제 12 항 또는 제 13 항에 따른 DVG 또는 제 14 항에 따른 결함이 있는 간섭 입자의 용도.
- WNV에 감염된 환자의 치료를 위한 약물의 제조를 위한, 제 12 항 또는 제 13 항에 따른 DVG 또는 제 14 항에 따른 결함이 있는 간섭 입자의 용도.
- CV, 특히 SARS-CoV-2에 의해 감염된 환자의 치료를 위한 약물의 제조를 위한, 제 12 항 또는 제 13 항에 따른 DVG 또는 제 14 항에 따른 결함이 있는 간섭 입자의 용도.
- 서열 번호: 1 (DG1 : EV71 DVG 293-390), 서열 번호: 2 (DG2 : EV71 DVG 294-404), 서열 번호: 3 (DG3 : EV71 DVG 1746-2895), 서열 번호: 4 (DG4 : EV71 DVG 1752-2894), 서열 번호: 5 (DG5 : EV71 DVG 1752-2896), 서열 번호: 6 (DG6 : EV71 DVG 1880-6487), 서열 번호: 7 (DG7 : EV71 DVG 1880-6488), 서열 번호: 8 (DG8 : EV71 DVG 3513-6516), 서열 번호: 9 (DG9 : EV71 DVG 5475-5634), 서열 번호: 10 (DG10: EV71 DVG 5610-6876), 서열 번호: 11 (DG11 : EV71 DVG 5610-6877), 서열 번호: 12 (DG12: EV71 DVG 5746-5821), 서열 번호: 13 (DG13 : EV71 DVG 6322-6356), 서열 번호: 14 (DG14: EV71 DVG 6322-6358), 서열 번호: 15 (DG15: EV71 DVG 6728-6779), 서열 번호: 16 (DG16: EV71 DVG 6966-7012), 서열 번호: 17 (DG17: EV71 DVG 6966-7014), 서열 번호: 18 (DG18: EV71 DVG 7098-7122), 서열 번호: 19 (DG19: EV71 DVG 7165-7200), 서열 번호: 20 (DG20: EV71 DVG 7165-7201), 서열 번호: 21 (DG21: EV71 DVG 7238-7292), 서열 번호: 22 (ZIKV DVG-A), 서열 번호: 23 (ZIKV DVG-B), 서열 번호: 24 (ZIKV DVG-C), 서열 번호: 25 (ZIKV DVG-D), 서열 번호: 26 (ZIKV DVG-E), 서열 번호: 27 (ZIKV DVG-F), 서열 번호: 28 (ZIKV DVG-G), 서열 번호: 29 (ZIKV DVG-H), 서열 번호: 30 (ZIKV DVG-I), 서열 번호: 31 (ZIKV DVG-J), 서열 번호: 32 (ZIKV DVG-K), 서열 번호: 33 (ZIKV DVG-L), 서열 번호: 34 (CHIKV DVG-IV1), 서열 번호: 35 (CHIKV DVG-IV2), 서열 번호: 36 (CHIKV DVG-IV3), 서열 번호: 37 (CHIKV DVG-IV4), 서열 번호: 38 (CHIKV DVG-IH1), 서열 번호: 39 (CHIKV DVG-IU1), 서열 번호: 40 (CHIKV DVG-CV1), 서열 번호: 41 (CHIKV DVG-CV2), 서열 번호: 42 (CHIKV DVG-CV3), 서열 번호: 43 (CHIKV DVG-CV4), 서열 번호: 44 (CHIKV DVG-CH1), 서열 번호: 45 (CHIKV DVG-CH2), 서열 번호: 46 (CHIKV DVG-CH3), 서열 번호: 47 (CHIKV DVG-CM1), 서열 번호: 48 (CHIKV DVG-CU1), 서열 번호: 49 (CHIKV DVG-CU2), 서열 번호: 50 (CHIKV DVG-CA1), 서열 번호: 51 (CHIKV DVG-CA2), 서열 번호: 52 (CHIKV DVG-CA3), 서열 번호: 53 (CHIKV DVG-CA4), 서열 번호: 55 (RV DVG A01a-TIP-01), 서열 번호: 56 (RV DVG A01a-TIP-02), 서열 번호: 57 (RV DVG A01a-TIP-03), 서열 번호: 58 (RV DVG A01a-TIP-04), 서열 번호: 59 (RV DVG A01a-TIP-05), 서열 번호: 60 (RV DVG A01a-TIP-06), 서열 번호: 62 (RV DVG A16-TIP-01), 서열 번호: 63 (RV DVG A16-TIP-02), 서열 번호: 64 (RV DVG A16-TIP-03), 서열 번호: 65 (RV DVG A16-TIP-04), 서열 번호: 66 (RV DVG A16-TIP-05), 서열 번호: 89 (RV DVG C15-TIP-01), 서열 번호: 90 (RV DVG C15-TIP-02), 서열 번호: 91 (RV DVG C15-TIP-03), 서열 번호: 92 (RV DVG C15-TIP-04), 서열 번호: 68 (RV DVG B14-TIP-01), 서열 번호: 69 (RV DVG B14-TIP-02), 서열 번호: 70 (RV DVG B14-TIP-03), 서열 번호: 71 (RV DVG B14-TIP-04), 서열 번호: 72 (RV DVG B14-TIP-05), 서열 번호: 73 (RV DVG B14-TIP-06), 서열 번호: 74 (RV DVG B14-TIP-07), 서열 번호: 75 (RV DVG B14-TIP-08), 서열 번호: 76 (RV DVG B14-TIP-09), 서열 번호: 77 (RV DVG B14-TIP-10), 서열 번호: 78 (RV DVG B14-TIP-11), 서열 번호: 79 (RV DVG B14-TIP-12), 서열 번호: 80 (RV DVG B14-TIP-13), 서열 번호: 81 (RV DVG B14-TIP-14), 서열 번호: 82 (RV DVG B14-TIP-15), 서열 번호: 83 (RV DVG B14-TIP-16), 서열 번호: 84 (RV DVG B14-TIP-17), 서열 번호: 85 (RV DVG B14-TIP-18), 서열 번호: 86 (RV DVG B14-TIP-19), 서열 번호: 87 (RV DVG B14-TIP-20), 서열 번호:93 (YFV DVG-A), 서열 번호: 94 (YFV DVG-B), 서열 번호: 95 (YFV DVG-C), 서열 번호: 96 (YFV DVG-D), 서열 번호: 97 (YFV DVG-E), 서열 번호: 98 (YFV DVG-F), 서열 번호: 99 (YFV DVG-G), 서열 번호: 100 (YFV DVG-H), 서열 번호: 101 (YFV DVG-I), 서열 번호: 102 (YFV DVG-J), 서열 번호: 103 (YFV DVG-K), 서열 번호: 104 (YFV DVG-L), 서열 번호:105 (WNV DVG-1), 서열 번호: 106 (WNV DVG-2), 서열 번호: 107 (WNV DVG-3), 서열 번호: 108 (WNV DVG-4), 서열 번호: 109 (WNV DVG-5), 서열 번호: 110 (WNV DVG-6), 서열 번호: 111 (SARS-CoV-2 DVG_1), 서열 번호: 112 (SARS-CoV-2 DVG_2) 및 서열 번호: 113 (SARS-CoV-2 DVG_3)로 이루어지는 군으로부터 선택되는 뉴클레오티드 서열, 또는 이러한 서열 중 하나와 적어도 70% 동일성, 더 바람직하게는 적어도 80% 동일성; 더 바람직하게는 적어도 90% 동일성, 더 바람직하게는 적어도 91% 동일성, 더 바람직하게는 적어도 92% 동일성, 더 바람직하게는 적어도 93% 동일성, 더 바람직하게는 적어도 94% 동일성, 더 바람직하게는 적어도 95% 동일성, 더 바람직하게는 적어도 96% 동일성, 더 바람직하게는 적어도 97% 동일성, 더 바람직하게는 적어도 98% 동일성, 또는 더 바람직하게는 적어도 99% 동일성을 가지는 뉴클레오티드 서열을 포함하거나 또는 이로 이루어지는, 폴리뉴클레오티드.
- 제 49 항에 따른 폴리뉴클레오티드를 포함하는 발현 벡터 또는 플라스미드.
- 제 12 항 또는 제 13 항에 따른 DVG를 생성하는 세포주.
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