CN116018404A - 缺陷干扰病毒基因组 - Google Patents
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Abstract
产生缺陷干扰病毒基因组(DVG)的方法、包含所述DVG的缺陷干扰粒子及其方法和用途。
Description
本发明的一部分是在美国政府的支持下,根据国防高级研究计划局(DefenseAdvanced Research Projects Agency,DARPA)批准的第HR0011-17-2-0023号协议完成的。美国政府对本发明享有一定的权利。
引言
本发明是在美国政府的支持下,根据国防高级研究计划局(DARPA)批准的DARPA协议号HR00111720023完成的。具有RNA基因组的病毒具有固有高错误率的聚合酶。由于这种容易出错的复制过程,这些病毒不仅会生成全长病毒基因组或具有点突变的基因组,而且还会生成有缺陷的基因组。已经描述了多种类型的缺陷基因组,包括截断(truncation)、插入、缺失、嵌合(mosaic)或重排的基因组和写回(copyback)/回转(snapback)。虽然大多数缺陷基因组被认为是RNA病毒复制的死端副产物,但这些缺陷病毒基因组(defectiveviral genome,DVG)的一个子集会干扰感染性子代病毒颗粒生成较高数目。
除高突变率外,重组是RNA病毒进化的另一个主要驱动力。非同源重组可产生构成缺陷病毒基因组(DVG)的截断和/或重排的病毒基因组。1954年,Von Magnus在甲型流感病毒中首次描述了DVG,此后所有病毒家族中都描述了DVG。由于缺乏部分基因组或其编码功能,DVG必须与其亲代病毒共同感染细胞,以利用全长病毒编码的蛋白质。因此,劫持复制机制或使用亲代病毒编码的蛋白质的DVG可与野生型病毒竞争资源,从而抑制亲代病毒。这些类型的DVG通常被称为缺陷干扰粒子(defective interfering particle,DIP)。此外,许多DVG在哺乳动物和无脊椎动物中都具有强大的免疫刺激潜力。在急性登革热病毒感染患者的血清中发现了DVG,但它们的病理生理作用尚不清楚。在人类中,它们的存在与流感病毒和呼吸道合胞病毒感染的轻型疾病和更好的治疗结果相关。所有这些原因都解释了人们重新燃起的对使用DVG作为抗病毒疗法的兴趣。
虽然已记载了DVG存在于大多数病毒中,但在许多病毒家族中,DVG并不被认为是相关的或占主导地位的。通常,对于任何给定的病毒,仅记载了少许DVG。这些先前的报告依赖于更经典的分离方法,例如PCR扩增,其仅选择一种或两种DVG,并偏向于最短或最丰富的DVG。就与野生型病毒竞争的能力而言,这些DVG不一定是最佳候选。因此,需要可复制且合理的方法来识别和生成最佳的DVG候选,以与野生型病毒感染竞争并对其进行干扰,该方法可用于任何感兴趣的病毒,尤其是人类病原体。本文公开的发明满足这些及其他需要。
我们组合的实验进化和计算方法识别了任何病毒的数千种不同的DVG。首先,我们的实验方法在病毒种群中生成所有可能的DVG。不出所料,我们的列表中包括类似于更经典方法所识别的DVG。其次,我们的计算分析使我们能够使用从序列数据估计的时间频率来预测哪些DVG作为缺陷干扰粒子的效果最好。使用这种组合方法,我们为属于不同病毒家族的多种病毒生成了最佳候选列表,其中最高达90%的病毒已证实具有干扰野生型病毒复制的能力。
发明内容
本发明提供了生成DVG的方法,还提供了由所述方法生成的新DVG。提供了由基孔肯雅病毒(chikungunya virus,CHIKV)、寨卡病毒(Zika virus,ZIKV)、肠道病毒71型(enterovirus 71,EV71)、西尼罗河病毒(West Nile virus,WNV)、黄热病病毒(yellowfever virus YFV)和鼻病毒(rhinovirus,RV)以及冠状病毒(coronavirus CV)(例如,最近发现的名为SARS-CoV-2、2019-nCov或COVID-19的新型冠状病毒)生成的DVG。
发明人已经使用新一代测序方法识别了DVG,随后进行了计算分析、热点分析识别了多种为缺失DVG(CHIKV、EV71、ZIKV以及RV病毒基因组的内部缺失)的DVG。随后,对这些DVG进行了基因改造,并测试了其降低CHIKV、EV71、ZIKV和RV的传染性病毒滴度的能力。成功的DVG候选有可能被用作治疗性干扰粒子(therapeutic interfering particle,TIP),其可用作一种治疗和限制病毒感染严重程度的新策略。此外,还识别了WNV和YFV的DVG。基于其他病毒的成功,这些DVG有可能用作TIP。
在第一方面,提供了一种用于产生缺陷干扰病毒基因组(DVG)的方法。该方法包括:提供第一组至少三种复制的体外细胞培养物,所述培养物包含固体载体和以高感染复数(multiplicity of infection,MOI)感染参照感染性病毒的细胞;提供第二组至少三种复制的体外细胞培养物,所述培养物包含固体载体和以低感染复数(MOI)感染参照感染性病毒的细胞;在正常生长条件下,将第一组和第二组复制的体外细胞培养物培养至少5代;从第一组和第二组体外复制的细胞培养物的培养基中收集多种DVG候选;对收集的DVG候选进行深度测序;从多种DVG候选中选择一个DVG的子集。
在一些实施方案中,该方法还包括提供第三组至少三种复制的体外细胞培养物,所述培养物包含固体载体和以高感染复数(MOI)感染参照感染性病毒的细胞;和/或提供第四组至少三种复制的体外细胞培养物,所述培养物包含固体载体和以低感染复数(MOI)感染参照感染性病毒的细胞;和在诱变条件下,将第三组和/或第四组复制的体外细胞培养物培养至少5代;或使用具有增变基因表型(mutator phenotype)的参照感染性病毒进行所述传代。
在一些实施方案中,从多种DVG候选中选择一种DVG包括:将DVG候选的序列与参照感染性病毒的基因组序列进行比较;识别具有包含至少一个剪接事件(splicing event)的基因组的至少一种DVG候选,其中所述剪接事件是缺失或重排;确定在已测序的DVG候选基因组群中具有包含至少一个剪接事件的基因组的至少一种DVG候选的相对频率;并且,选择至少一种DVG,其中:a)至少一个剪接事件在高MOI培养物中比在低MOI培养物中更丰富;和/或b)至少一个剪接事件出现在至少2、3、4、5、6、7、8或9个不同的细胞系中;和/或,c)在至少5、10、15或20次传代后,在至少12、24或36次独立复制的至少3次中发现至少一个剪接事件;和/或,d)至少一个剪接事件是缺失事件,并且缺失的核苷酸大小是至少40、42、50、100、150、200、400、600或1000个核苷酸;和/或,e)保留该DVG中的开放阅读框;和/或,f)病毒复制所需的结构域和功能保留在该DVG中;和/或g)该DVG包含至少一种降低参照感染性病毒的自我复制能力的突变。
在一些实施方案中,DVG的特征在于对参照感染性病毒的体外抑制活性为至少50%、60%、70%、80%或90%。在一些实施方案中,参照感染性病毒是基孔肯雅病毒(chikungunya virus,CHIKV)、寨卡病毒(Zika virus,ZIKV)、肠道病毒71型(enterovirus71,EV71)、鼻病毒(rhinovirus,RV)、黄热病病毒(yellow fever virus,YFV)或西尼罗河病毒(West Nile virus,WNV)。在一些实施方案中,参照感染性病毒选自由以下组成的组:CHIKV印度洋谱系(GenBank登录号AM258994)、CHIKV加勒比海毒株(GenBank登录号LN898104.1)、ZIKV非洲株MR766(KY989511.1)、EV71 Sep006(GenBank:KX197462.1)、RV-A01a(NC_038311.1)、RV-A16(L24917.1)、RV-B14(L05355.1)、RV-C15(GU219984.1)、西尼罗河病毒以色列1998和YFV毒株,黄热病病毒Asibi(YF-Asibi)毒株和黄热病病毒疫苗(YF-17D)毒株。在一些实施方案中,参照感染性病毒是SARS-CoV-2(Zhu N等人,《新英格兰医学杂志》(N Engl J Med.),2020年1月24日)。在一些实施方案中,细胞是选自由以下组成的组的哺乳动物细胞系:源自非洲绿猴肾细胞的细胞系(可选Vero,可选Vero-E6细胞系)、源自人类肌肉的细胞系(可选RD细胞系)、源自幼仓鼠肾的细胞系(可选BHK细胞系)、源自人类胚胎肾细胞的细胞系(可选HEK293T细胞系)、源自肝癌细胞的细胞系(可选Huh7细胞系)和源自宫颈腺癌的细胞系(可选H1-HeLa,可选HeLa-E8细胞系)。在一些实施方案中,细胞是选自由以下组成的组的蚊子细胞系:源自埃及伊蚊(Aedes aegypti)的细胞系(可选Aag2细胞系)、源自白纹伊蚊(Aedes albopictus)的细胞(可选C6/36细胞系)和源自白纹伊蚊(Aedesalbopictus)的细胞系(可选U4.4细胞系)。在一些实施方案中,用于感染的低MOI为0.001至0.1空斑形成单位/细胞(PFU/cell),特别是0.01至0.1PFU/细胞。在一些实施方案中,用于感染的高MOI为1至100PFU/细胞。
还提供了一种通过本发明的方法产生的DVG。
还提供了一种DVG,其包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:1(DG1:EV71 DVG 293-390)、SEQ ID NO:2(DG2:EV71DVG 294-404)、SEQ ID NO:3(DG3:EV71 DVG 1746-2895)、SEQ ID NO:4(DG4:EV71 DVG1752-2894)、SEQ ID NO:5(DG5:EV71 DVG 1752-2896)、SEQ ID NO:6(DG6:EV71 DVG 1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQ ID NO:8(DG8:EV71 DVG 3513-6516)、SEQ ID NO:9(DG9:EV71 DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG 5610-6876)、SEQ ID NO:11(DG11:EV71 DVG 5610-6877)、SEQ ID NO:12(DG12:EV71 DVG 5746-5821)、SEQ ID NO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71 DVG 6322-6358)、SEQ ID NO:15(DG15:EV71 DVG 6728-6779)、SEQ ID NO:16(DG16:EV71 DVG 6966-7012)、SEQ ID NO:17(DG17:EV71 DVG 6966-7014)、SEQ ID NO:18(DG18:EV71 DVG 7098-7122)、SEQ ID NO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71 DVG 7165-7201)、SEQ ID NO:21(DG21:EV71 DVG 7238-7292)、SEQ ID NO:22(ZIKV DVG-A)、SEQ IDNO:23(ZIKV DVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ IDNO:26(ZIKV DVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ IDNO:29(ZIKV DVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ IDNO:32(ZIKV DVG-K)、SEQ ID NO:33(ZIKV DVG-L)、SEQ ID NO:34(CHIKV DVG-IV1)、SEQ IDNO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKV DVG-IV4)、SEQ ID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKVDVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQ ID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:45(CHIKV DVG-CH2)、SEQID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)、SEQ ID NO:53(CHIKV DVG-CA4)、SEQID NO:55(RV DVG A01a-TIP-01)、SEQ ID NO:56(RV DVG A01a-TIP-02)、SEQ ID NO:57(RVDVG A01a-TIP-03)、SEQ ID NO:58(RV DVG A01a-TIP-04)、SEQ ID NO:59(RV DVG A01a-TIP-05)、SEQ ID NO:60(RV DVG A01a-TIP-06)、SEQ ID NO:62(RV DVG A16-TIP-01)、SEQID NO:63(RV DVG A16-TIP-02)、SEQ ID NO:64(RV DVG A16-TIP-03)、SEQ ID NO:65(RVDVG A16-TIP-04)、SEQ ID NO:66(RV DVG A16-TIP-05)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ ID NO:91(RV DVG C15-TIP-03)、SEQ IDNO:92(RV DVG C15-TIP-04)、SEQ ID NO:68(RV DVG B14-TIP-01)、SEQ ID NO:69(RV DVGB14-TIP-02)、SEQ ID NO:70(RV DVG B14-TIP-03)、SEQ ID NO:71(RV DVG B14-TIP-04)、SEQ ID NO:72(RV DVG B14-TIP-05)、SEQ ID NO:73(RV DVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ ID NO:75(RV DVG B14-TIP-08)、SEQ ID NO:76(RV DVG B14-TIP-09)、SEQ ID NO:77(RV DVG B14-TIP-10)、SEQ ID NO:78(RV DVG B14-TIP-11)、SEQID NO:79(RV DVG B14-TIP-12)、SEQ ID NO:80(RV DVG B14-TIP-13)、SEQ ID NO:81(RVDVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ ID NO:83(RV DVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ ID NO:85(RV DVG B14-TIP-18)、SEQ IDNO:86(RV DVG B14-TIP-19)、SEQ ID NO:87(RV DVG B14-TIP-20)、SEQ ID NO:93(YFVDVG-A)、SEQ ID NO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQ ID NO:96(YFV DVG-D)、SEQ ID NO:97(YFV DVG-E)、SEQ ID NO:98(YFV DVG-F)、SEQ ID NO:99(YFV DVG-G)、SEQ ID NO:100(YFV DVG-H)、SEQ ID NO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFV DVG-K)、SEQ ID NO:104(YFV DVG-L),SEQ ID NO:105(WNV DVG-1),SEQ ID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ ID NO:109(WNV DVG-5)、SEQ ID NO:110(WNV DVG-6)、SEQ ID NO:111(SARS-CoV-2DVG_1)、SEQ ID NO:112(SARS-CoV-2 DVG_2)和SEQ ID NO:113(SARS-CoV-2 DVG_3),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了一种包含本发明的DVG的缺陷干扰粒子。
还提供了治疗受试者病毒感染的方法,包括施用治疗有效量的至少一种根据本发明的DVG或缺陷干扰粒子。
在一些实施方案中,DVG作为RNA——裸RNA或用适当载体例如纳米颗粒或脂质配制的RNA——施用。
在一些实施方案中,DVG作为包装的RNA、病毒样颗粒(virus-like particle,VLP)或其他包装载体施用。
在一些实施方案中,DVG是在宿主适当的转录启动子的控制下从DNA转录而来。
在一些实施方案中,至少一种DVG是缺陷干扰CHIKV基因组。在一些实施方案中,至少一种缺陷干扰CHIKV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:34(CHIKV DVG-IV1)、SEQ ID NO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKV DVG-IV4)、SEQ ID NO:38(CHIKVDVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKV DVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQ ID NO:43(CHIKV DVG-CV4)、SEQID NO:44(CHIKV DVG-CH1)、SEQ ID NO:45(CHIKV DVG-CH2)、SEQ ID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQID NO:52(CHIKV DVG-CA3)和SEQ ID NO:53(CHIKV DVG-CA4),或与这些序列之一具有至少70%同一性、更优选至少80%的同一性;更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
在一些实施方案中,至少一种缺陷干扰基因组是缺陷干扰ZIKV基因组。在一些实施方案中,至少一种干扰ZIKV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:22(ZIKV DVG-A)、SEQ ID NO:23(ZIKV DVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ ID NO:26(ZIKV DVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ ID NO:29(ZIKV DVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ ID NO:32(ZIKV DVG-K)和SEQ ID NO:33(ZIKV DVG-L),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
在一些实施方案中,至少一种缺陷干扰基因组是缺陷干扰EV71基因组。在一些实施方案中,至少一种缺陷干扰性EV71基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:1(DG1:EV71 DVG 293-390)、SEQ ID NO:2(DG2:EV71 DVG 294-404)、SEQ ID NO:3(DG3:EV71 DVG 1746-2895)、SEQ ID NO:4(DG4:EV71 DVG 1752-2894)、SEQ ID NO:5(DG5:EV71 DVG 1752-2896)、SEQ ID NO:6(DG6:EV71DVG 1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQ ID NO:8(DG8:EV71 DVG3513-6516)、SEQ ID NO:9(DG9:EV71 DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG5610-6876)、SEQ ID NO:11(DG11:EV71 DVG 5610-6877)、SEQ ID NO:12(DG12:EV71 DVG5746-5821)、SEQ ID NO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71DVG6322-6358)、SEQ ID NO:15(DG15:EV71 DVG 6728-6779)、SEQ ID NO:16(DG16:EV71 DVG6966-7012)、SEQ ID NO:17(DG17:EV71 DVG 6966-7014)、SEQ ID NO:18(DG18:EV71 DVG7098-7122)、SEQ ID NO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71 DVG7165-7201)和SEQ ID NO:21(DG21:EV71 DVG 7238-7292),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
在一些实施方案中,至少一种缺陷干扰基因组是缺陷干扰RV基因组。在一些实施方案中,至少一种缺陷干扰RV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:55(RV DVG A01a-TIP-01)、SEQ ID NO:56(RVDVG A01a-TIP-02)、SEQ ID NO:57(RV DVG A01a-TIP-03)、SEQ ID NO:58(RV DVG A01a-TIP-04)、SEQ ID NO:59(RV DVG A01a-TIP-05)、SEQ ID NO:60(RV DVG A01a-TIP-06)、SEQID NO:62(RV DVG A16-TIP-01)、SEQ ID NO:63(RV DVG A16-TIP-02)、SEQ ID NO:64(RVDVG A16-TIP-03)、SEQ ID NO:65(RV DVG A16-TIP-04)、SEQ ID NO:66(RV DVG A16-TIP-05)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ IDNO:91(RV DVG C15-TIP-03)、SEQ ID NO:92(RV DVG C15-TIP-04)、SEQ ID NO:68(RV DVGB14-TIP-01)、SEQ ID NO:69(RV DVG B14-TIP-02)、SEQ ID NO:70(RV DVG B14-TIP-03)、SEQ ID NO:71(RV DVG B14-TIP-04)、SEQ ID NO:72(RV DVG B14-TIP-05)、SEQ ID NO:73(RV DVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ ID NO:75(RV DVG B14-TIP-08)、SEQ ID NO:76(RV DVG B14-TIP-09)、SEQ ID NO:77(RV DVG B14-TIP-10)、SEQID NO:78(RV DVG B14-TIP-11)、SEQ ID NO:79(RV DVG B14-TIP-12)、SEQ ID NO:80(RVDVG B14-TIP-13)、SEQ ID NO:81(RV DVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ ID NO:83(RV DVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ IDNO:85(RV DVG B14-TIP-18)、SEQ ID NO:86(RV DVG B14-TIP-19)和SEQ ID NO:87(RV DVGB14-TIP-20),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
在一些实施方案中,至少一种缺陷干扰基因组是缺陷干扰YFV基因组。在一些实施方案中,至少一种缺陷干扰YFV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:93(YFV DVG-A)、SEQ ID NO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQ ID NO:96(YFV DVG-D)、SEQ ID NO:97(YFV DVG-E)、SEQID NO:98(YFV DVG-F)、SEQ ID NO:99(YFV DVG-G)、SEQ ID NO:100(YFV DVG-H)、SEQ IDNO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFV DVG-K)和SEQ IDNO:104(YFV DVG-L),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
在一些实施方案中,至少一种缺陷干扰基因组是缺陷干扰WNV基因组。在一些实施方案中,至少一种缺陷干扰WNV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:105(WNV DVG-1)、SEQ ID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ ID NO:109(WNV DVG-5)和SEQ ID NO:110(WNV DVG-6),或与这些序列之一具有至少70%同一性、更优选至少80%的同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
在一些实施方案中,至少一种缺陷干扰基因组是缺陷干扰CV基因组,例如缺陷干扰SARS-CoV-2基因组。在一些实施方案中,至少一种缺陷干扰SARS-CoV-2基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:111(SARS-CoV-2 DVG_1)、SEQ ID NO:112(SARS-CoV-2 DVG_2)和SEQ ID NO:113(SARS-CoV-2 DVG_3),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了本发明的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者CHIKV感染的方法中,其中所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:34(CHIKV DVG-IV1)、SEQ ID NO:35(CHIKVDVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKV DVG-IV4)、SEQ ID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKV DVG-CV1)、SEQID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQ ID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:45(CHIKV DVG-CH2)、SEQ ID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)和SEQ ID NO:53(CHIKV DVG-CA4),或与这些序列之一具有至少70%同一性、更优选至少80%的同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了本发明的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者ZIKV感染的方法中,其中所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:22(ZIKV DVG-A)、SEQ ID NO:23(ZIKV DVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ ID NO:26(ZIKV DVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ ID NO:29(ZIKV DVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ ID NO:32(ZIKV DVG-K)和SEQ ID NO:33(ZIKV DVG-L),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了本发明的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者EV71感染的方法中,其中所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:1(DG1:EV71 DVG 293-390)、SEQ ID NO:2(DG2:EV71 DVG 294-404)、SEQ ID NO:3(DG3:EV71 DVG 1746-2895)、SEQ ID NO:4(DG4:EV71DVG 1752-2894)、SEQ ID NO:5(DG5:EV71 DVG 1752-2896)、SEQ ID NO:6(DG6:EV71 DVG1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQ ID NO:8(DG8:EV71 DVG 3513-6516)、SEQ ID NO:9(DG9:EV71 DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG 5610-6876)、SEQ ID NO:11(DG11:EV71 DVG 5610-6877)、SEQ ID NO:12(DG12:EV71 DVG 5746-5821)、SEQ ID NO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71 DVG 6322-6358)、SEQ ID NO:15(DG15:EV71 DVG 6728-6779)、SEQ ID NO:16(DG16:EV71 DVG 6966-7012)、SEQ ID NO:17(DG17:EV71 DVG 6966-7014)、SEQ ID NO:18(DG18:EV71 DVG 7098-7122)、SEQ ID NO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71 DVG 7165-7201)和SEQ ID NO:21(DG21:EV71 DVG 7238-7292),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了本发明的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者RV感染的方法中,其中所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:55(RV DVG A01a-TIP-01)、SEQ ID NO:56(RV DVGA01a-TIP-02)、SEQ ID NO:57(RV DVG A01a-TIP-03)、SEQ ID NO:58(RV DVG A01a-TIP-04)、SEQ ID NO:59(RV DVG A01a-TIP-05)、SEQ ID NO:60(RV DVG A01a-TIP-06)、SEQ IDNO:62(RV DVG A16-TIP-01)、SEQ ID NO:63(RV DVG A16-TIP-02)、SEQ ID NO:64(RV DVGA16-TIP-03)、SEQ ID NO:65(RV DVG A16-TIP-04)、SEQ ID NO:66(RV DVG A16-TIP-05)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ ID NO:91(RV DVG C15-TIP-03)、SEQ ID NO:92(RV DVG C15-TIP-04)、SEQ ID NO:68(RV DVG B14-TIP-01)、SEQ ID NO:69(RV DVG B14-TIP-02)、SEQ ID NO:70(RV DVG B14-TIP-03)、SEQID NO:71(RV DVG B14-TIP-04)、SEQ ID NO:72(RV DVG B14-TIP-05)、SEQ ID NO:73(RVDVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ ID NO:75(RV DVG B14-TIP-08)、SEQ ID NO:76(RV DVG B14-TIP-09)、SEQ ID NO:77(RV DVG B14-TIP-10)、SEQ IDNO:78(RV DVG B14-TIP-11)、SEQ ID NO:79(RV DVG B14-TIP-12)、SEQ ID NO:80(RV DVGB14-TIP-13)、SEQ ID NO:81(RV DVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ ID NO:83(RV DVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ ID NO:85(RV DVG B14-TIP-18)、SEQ ID NO:86(RV DVG B14-TIP-19)和SEQ ID NO:87(RV DVG B14-TIP-20),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了本发明的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者YFV感染的方法中,其中所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:93(YFV DVG-A)、SEQ ID NO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQ ID NO:96(YFV DVG-D)、SEQ ID NO:97(YFV DVG-E)、SEQID NO:98(YFV DVG-F)、SEQ ID NO:99(YFV DVG-G)、SEQ ID NO:100(YFV DVG-H)、SEQ IDNO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFV DVG-K)和SEQ IDNO:104(YFV DVG-L),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了本发明的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者WNV感染的方法,其中所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:105(WNV DVG-1)、SEQ ID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ ID NO:109(WNV DVG-5)和SEQ ID NO:110(WNV DVG-6),或与这些序列之一具有至少70%同一性、更优选至少80%的同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了本发明的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者CV感染的方法中,其中所述CV感染由SARS-CoV-2引起,并且其中所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:111(SARS-CoV-2 DVG_1)、SEQ ID NO:112(SARS-CoV-2 DVG_2)和SEQ ID NO:113(SARS-CoV-2DVG_3),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
还提供了一种药物组合物、免疫原性组合物或治疗组合物,其包含至少一种根据本发明的DVG和药学上可接受的载体。
还提供了一种药物组合物、免疫原性组合物或治疗组合物,其包含至少一种根据本发明的缺陷干扰粒子和药学上可接受的载体。
还提供了一种包含本发明的免疫原性组合物的疫苗。
还提供了本发明的DVG或本发明的缺陷干扰粒子在制备用于治疗感染DVG或缺陷干扰粒子的靶病毒患者的药物中的用途。
还提供了本发明的DVG或本发明的缺陷干扰粒子在制备用于治疗感染CHIKV患者的药物中的用途。
还提供了本发明的DVG或本发明的缺陷干扰粒子在制备用于治疗感染ZIKV患者的药物中的用途。
还提供了本发明的DVG或本发明的缺陷干扰粒子在制备用于治疗感染EV71患者的药物中的用途。
还提供了本发明的DVG或本发明的缺陷干扰粒子在制备用于治疗感染RV患者的药物中的用途。
还提供了本发明的DVG或本发明的缺陷干扰粒子在制备用于治疗感染YFV患者的药物中的用途。
还提供了本发明的DVG或本发明的缺陷干扰粒子在制备用于治疗感染WNV患者的药物中的用途。
还提供了本发明的DVG或本发明的缺陷干扰粒子在制备用于治疗感染CV、特别是SARS-CoV-2患者的药物中的用途。
还提供了一种多核苷酸,其包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:1(DG1:EV71 DVG 293-390)、SEQ ID NO:2(DG2:EV71 DVG 294-404)、SEQ ID NO:3(DG3:EV71 DVG 1746-2895)、SEQ ID NO:4(DG4:EV71DVG 1752-2894)、SEQ ID NO:5(DG5:EV71 DVG 1752-2896)、SEQ ID NO:6(DG6:EV71 DVG1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQ ID NO:8(DG8:EV71 DVG 3513-6516)、SEQ ID NO:9(DG9:EV71 DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG 5610-6876)、SEQ ID NO:11(DG11:EV71 DVG 5610-6877)、SEQ ID NO:12(DG12:EV71 DVG 5746-5821)、SEQ ID NO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71 DVG 6322-6358)、SEQ ID NO:15(DG15:EV71 DVG 6728-6779)、SEQ ID NO:16(DG16:EV71 DVG 6966-7012)、SEQ ID NO:17(DG17:EV71 DVG 6966-7014)、SEQ ID NO:18(DG18:EV71 DVG 7098-7122)、SEQ ID NO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71 DVG 7165-7201)、SEQ ID NO:21(DG21:EV71 DVG 7238-7292)、SEQ ID NO:22(ZIKV DVG-A)、SEQ IDNO:23(ZIKV DVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ IDNO:26(ZIKV DVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ IDNO:29(ZIKV DVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ IDNO:32(ZIKV DVG-K)、SEQ ID NO:33(ZIKV DVG-L)、SEQ ID NO:34(CHIKV DVG-IV1)、SEQ IDNO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKV DVG-IV4)、SEQ ID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKVDVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQ ID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:45(CHIKV DVG-CH2)、SEQID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)、SEQ ID NO:53(CHIKV DVG-CA4)、SEQID NO:55(RV DVG A01a-TIP-01)、SEQ ID NO:56(RV DVG A01a-TIP-02)、SEQ ID NO:57(RVDVG A01a-TIP-03)、SEQ ID NO:58(RV DVG A01a-TIP-04)、SEQ ID NO:59(RV DVG A01a-TIP-05)、SEQ ID NO:60(RV DVG A01a-TIP-06)、SEQ ID NO:62(RV DVG A16-TIP-01)、SEQID NO:63(RV DVG A16-TIP-02)、SEQ ID NO:64(RV DVG A16-TIP-03)、SEQ ID NO:65(RVDVG A16-TIP-04)、SEQ ID NO:66(RV DVG A16-TIP-05)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ ID NO:91(RV DVG C15-TIP-03)、SEQ IDNO:92(RV DVG C15-TIP-04)、SEQ ID NO:68(RV DVG B14-TIP-01)、SEQ ID NO:69(RV DVGB14-TIP-02)、SEQ ID NO:70(RV DVG B14-TIP-03)、SEQ ID NO:71(RV DVG B14-TIP-04)、SEQ ID NO:72(RV DVG B14-TIP-05)、SEQ ID NO:73(RV DVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ ID NO:75(RV DVG B14-TIP-08)、SEQ ID NO:76(RV DVG B14-TIP-09)、SEQ ID NO:77(RV DVG B14-TIP-10)、SEQ ID NO:78(RV DVG B14-TIP-11)、SEQID NO:79(RV DVG B14-TIP-12)、SEQ ID NO:80(RV DVG B14-TIP-13)、SEQ ID NO:81(RVDVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ ID NO:83(RV DVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ ID NO:85(RV DVG B14-TIP-18)、SEQ IDNO:86(RV DVG B14-TIP-19)、和SEQ ID NO:87(RV DVG B14-TIP-20)、SEQ ID NO:93(YFVDVG-A)、SEQ ID NO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQ ID NO:96(YFV DVG-D)、SEQ ID NO:97(YFV DVG-E)、SEQ ID NO:98(YFV DVG-F)、SEQ ID NO:99(YFV DVG-G)、SEQ ID NO:100(YFV DVG-H)、SEQ ID NO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFV DVG-K)、SEQ ID NO:104(YFV DVG-L),SEQ ID NO:105(WNV DVG-1),SEQ ID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ ID NO:109(WNV DVG-5)、SEQ ID NO:110(WNV DVG-6)、SEQ ID NO:111(SARS-CoV-2DVG_1)、SEQ ID NO:112(SARS-CoV-2 DVG_2)和SEQ ID NO:113(SARS-CoV-2 DVG_3),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的多核苷酸。
还提供了一种包含本发明的多核苷酸的表达载体或质粒。
还提供了一种产生根据本发明的DVG的细胞系。
参考以下非限制性实施例将更充分地理解本发明。
实施例
实施例1:方法
病毒的生长
传统上,当病毒以高感染复数(MOI)传代时,会观察到DVG。大多数已发表的工作是基于从少数传代和少数复制中识别DVG,从而识别出单个最丰富的DVG,通常通过偏向于识别具有最大缺失的最短DVG的方法(例如,通过使用跨越RNA基因组5’端和3’端的引物进行RT-PCR扩增)。这导致了一种观念,即任何给定的病毒只会生成少量DVG。我们发现,就序列而言,DVG的数量在数百到数千之间;并且用于干扰的最佳候选DVG不一定是出现在单一生长条件下的单个最丰富的DVG。在我们的方法中,野生型病毒在低(对照)和高MOI条件下以及在我们发现会增加缺陷基因组生成的诱变条件下进行传代。这些诱变条件包括:产生比天然野生型病毒更多错误的病毒的增变基因变体,或增加这些错误率的外在处理(例如,碱基类似物,如利巴韦林、5-氟尿嘧啶、5-氮杂胞苷、T705,或其他处理,例如提高温度或用Mn++补充培养基)。病毒以高生物复制数(3、12、24或36)传代,最多传代10次。我们观察到5次传代足以生成所需的数据。我们还建议使用多种细胞类型或不同的宿主,因为我们观察到细胞系和宿主之间偏好的DVG类型存在差异。
确定DVG候选
来自传代系列的病毒经过深度测序,以表征整个基因组中发生的每一次缺失或重排。描述特定缺失/重排的读数相对于该位置的总读数被用作该缺失在整个病毒种群中出现的频率的指标。使用这种方法为任何给定的病毒找到成百上千个不同的DVG。我们使用计算工具来确定这些DVG中哪些出现的频率和丰度高,以及哪些在复制之间是冗余的,以选择10-20个最佳候选进行进一步测试。
我们使用以下标准和原理预测哪些DVG将成为最佳TIP候选,基于这种假设:与野生型相比,良好的候选者将具有相对较高的复制适应度,将与野生型一起在细胞之间进行蛋白质外壳包裹或传代,将与野生型竞争并对其进行干扰,将保留增殖所需的域和功能,将在不同的细胞类型和宿主中保持适应度:
在群中以较高频率出现的DVG最有可能存活(能够复制或被野生型病毒复制)并且更有可能与野生型病毒竞争。
出现在整个传代系列事件中的DVG最有可能能够与野生型竞争,并用蛋白质外壳包裹在VLP中,以感染新细胞。
在超过三次生物复制中出现的DVG更有可能具有足够高的适应度来与野生型竞争,并且可能保留了复制和增殖所需的结构和功能元素。
在超过一种细胞类型或宿主中出现的DVG更有可能在不同的细胞条件下存活。
在高MOI或诱变条件下以较高频率出现的DVG与在低MOI条件下以较高频率出现的DVG相比,更有可能成为野生型病毒的真正竞争对手。
此外,我们将缺失(断点)起始和终止的核苷酸位置与预测的基因组RNA结构相匹配(参见实施例2,图8-22)。我们发现,虽然小的缺失在整个基因组中随机发生,但符合上述标准的DVG候选中较大的缺失发生在关键结构位点。也就是说,病毒的预测RNA结构可用于预测大缺失将发生的位置,以及其是否会产生存活的DVG候选。
我们观察到DVG可通过多于一种机制进行干扰和影响。经典观点是,较短的DVG从野生型中窃取复制机制并在竞争中胜过野生型,因为它们较短的基因组复制速度更快。但是,我们观察到的其他机制包括:通过提供比通常所需更多的一些病毒蛋白来改变野生型可用的病毒蛋白的化学计量的DVG;生成诱导细胞反应和危险信号的错误折叠的蛋白质的DVG;编码错误蛋白质的DVG,所述错误蛋白质通过“毒化”野生型复制和组装来产生无法生存的野生型病毒;诱导先天免疫和其他细胞反应因为其更容易被感知为危险信号的DVG。理想的DVG可呈现这些机制中的一个、部分或全部,或者由DVG的混合物组成,其中每种DVG都表现出其中的一些机制。
使用这种方法,我们获得了以下病毒和毒株的总DVG谱(数百到数千):
基孔肯雅病毒,加勒比海和印度洋岛屿毒株(Caribbean and Indian Oceanislands strain);
寨卡病毒,非洲毒株(African strain);
肠道病毒A71型;
鼻病毒A01a、A16、B14和C15;
黄热病病毒17D疫苗毒株和Asibi;和
西尼罗病毒。
冠状病毒,特别是SARS-CoV-2株(BetaCoV/France/IDF0372/2020)。
从这些列表中,使用上述选择标准,我们确定了每种病毒的最佳候选。最佳候选的顶部序列(top sequence)在随附的信息序列列表中提供。确定最佳候选列表之后,制备DVG的感染性克隆并在体外进行测试,然后在体内进行测试。我们的结果表明,这种识别和向下选择(down-selection)的方法具有非常高的成功率,其中50-90%的候选者在表现出对野生型病毒的体外抑制活性。
方法示例
方法的示例如图1至图7所示。
图1示出在低/高MOI或诱变条件下的传代方法。
图2示出检测缺失的生物信息学管道(bioinformatics pipeline)。
图3示出缺失的热图示例(heat map example)。
图4示出起始/终止示例。
图5示出样本示例中特定的缺失。
图6示出细胞类型示例的差异。
图7示出诱变条件样本。
实施例2:肠道病毒A71型(EV71)
EV71中出现的所有DVG的生成和表征
用Vero细胞接种12孔板,在第二天达到约90%的融合度(confluency)。使用Lipofectamine 2000(Life Technologies),将12个孔用500ng pCAGGS-EV71_Sep006(EV71Sep006-GenBank:KX197462.1)单独转染,以从稳定的背景中产生感染性病毒。随后用300μl病毒上清液感染Vero细胞。或者用固定的低体积(3μl)或高体积(300μl)感染12孔板的Vero或RD细胞。细胞在37℃和5% CO2下培养直到孔显示>90% CPE。在两次冻融循环后,新鲜融合的单层细胞被感染。使用12次复制重复12次。
通过离心(13,000g 30分钟)处理上清液,然后进行RNA酶A(RnaseA)处理(1μl;Thermo;37℃下3小时)或PEG沉淀(10mM HEPES(Sigma),pH 8.0,0.8% PEG8000(Sigma)和50mM NaCl(Sigma)),然后再以13,500x g离心1小时。使用Trizol(Sigma)从澄清的上清液中提取RNA。
使用NEBNext RNA第一链缓冲液(NEB)对样本RNA进行片段化,并在94℃下加热片段化15分钟。RNAseq文库是使用Illumina的NEBNext Ultra II非定向RNA文库制备试剂盒(NEB)根据制造商的说明生成的。为了允许样本的复用,使用Illumina的NEBNext复用寡核苷酸(NEB)生成索引。使用Illumina NextSeq 500/550Mid Output Reagent Cartridge v2和Illumina NextSeq 500/550Mid Output Flow Cell Cartridge v2.5,使用150次循环单端读数,在Illumina NextSeq500测序仪上对所生成的文库进行汇集和测序。使用基于BBMap套件的计算管道分析获得的序列。
通过复制、传代和细胞系之间的重复发生分析最初识别的DVG。这产生了一个15种DVG的列表,这些DVG被用于分析干扰活动,从而确定这些DVG是否可以用作TIP。在已识别的15种DVG中,有6种导致缺失,所述缺失会导致断点后的无义突变。作为对照,调整这6种DVG的缺失长度以保留开放阅读框。因此,评估的候选列表是21种DVG。
图8:EV71的连续传代。用EV71以3μl(低)或300μl(高)的固定体积感染12种复制的Vero或RD细胞。培养感染直到细胞显示>90% CPE。病毒连续传代超过12次。使用TCID50测定病毒滴度,并计算使用这些固定体积可获得的MOI范围。
图9:EV71的缺失热图。通过RNAseq分析来自连续传代的样本,并使用基于BBMap的管道检测缺失。随后,将每个细胞系、条件和传代中的各复制进行汇集并可视化,以显示每种缺失核苷酸相对于病毒基因组中位置的频率的热图。总体而言,缺失热点相对较小,并且通常具有相对于该基因组的不同位置。
图10:IRES中的缺失热点。将缺失热点与病毒基因组对齐,在传代和细胞系中存在一个位于EV71的5’UTR的强热点。更仔细的分析表明,该热点对应于IRES的茎环IV的顶部(用红色圈出),这是启动RNA向病毒多聚蛋白的有效翻译所必需的。
图11:衣壳中的缺失热点。EV71的许多缺失热点位于基因组的衣壳区域。该区域对应病毒的结构蛋白。一个经常缺失的区域的示例标记在方框(黑色)中,并且与基因组相关的缺失示意图示出了主要衣壳蛋白VP1内的缺失,以及跨越VP3和VP1的大部分的较大缺失。
图12:3C中的缺失热点。EV71中的3C蛋白具有双重功能,它是病毒的主要蛋白酶,可将多聚蛋白切割成单独的功能蛋白。同时,3C蛋白也是主要的干扰素拮抗剂,因此也是抵消细胞先天免疫应答的主要蛋白。该蛋白质的长度为183个氨基酸,而蛋白质的3C活性侧由至少六个残基组成(用红色标记)。有趣的是,3C中的缺失热点似乎与所述活性侧重叠,这表明缺失会使蛋白质失去功能。
图13:3D中的缺失热点。病毒聚合酶位于3D蛋白中。缺失热图表明整个蛋白质中存在许多不同的小缺失。有趣的是,开放阅读框的3’端有两个热信号,它们似乎位于两个预测的茎环结构内,这些结构也在脊髓灰质炎病毒中发现,并与病毒的充分复制有关。
进一步检查了缺失候选以及其他DVG,以确定观察到的缺失序列是否与特定的核苷酸特征或RNA结构相关。
图14:断点后核苷酸的互补性。为了分析断点周围核苷酸的互补性,对核苷酸进行单独评估,并对起始断点后的位置1-6与终止断点后的位置1-6进行测试。该图的y轴上显示互补频率,x轴上显示缺失长度的核苷酸阈值,即所述尺寸和更大的所有缺失。41个核苷酸或更短的缺失不依赖于断点周围的互补性,这表明聚合酶沿着基因组滑动作为作用方式。互补的频率逐渐增加,表明缺失越长,断点周围的互补性就越重要。对于长度大于79个核苷酸的缺失,约95%的缺失具有第一个核苷酸位置,约88.5%的缺失具有互补的前三个核苷酸位置。随机事件预计为约25%。
图15:断点周围核苷酸的互补性在病毒中被保留。对于CHIKV加勒比海毒株(CHIKVc)、CHIKV IOL(CHIKVi)、ZIKV、EV71和RV-B14(RV)分析断点周围互补性的重要性。y轴表示互补频率,而x轴表示起始位置和终止位置周围的核苷酸排列。有趣的是,在互补性的阳性信号旁边,缺失与断点前核苷酸位置上小于1%的阴性信号相吻合。在断点或引物之后互补的核苷酸数量因单独的病毒而异。对于CHIKV,核苷酸数量为约2个核苷酸(nts),对于ZIKV,核苷酸数量为3-5nts,对于EV71,核苷酸数量为3-4nts,对于RV,核苷酸数量为2nts。
图16:42nt以上缺失的互补图示出EV71使用“解除关联和重新准备(disassociateand re-prime)”本定机制。在“引物”序列之前的位置具有强烈的阴性信号,其几乎从不完全相同(约0.5%的时间-约25%是随机的)。有各种引物长度,但对于EV71,平均长度似乎为3nt。
图17:断点周围的互补序列示例:所示为DVG的三个示例,它们利用聚合酶可用以重新附着和重新启动转录的断点周围的互补核苷酸序列,导致这两个互补基因组区域之间的序列的内部缺失。
图18:断点周围的互补核苷酸通常位于RNA二级结构的环中。EV71的全基因组RNA二级结构使用RNA折叠(右)进行建模。缺失被映射到该结构上,热点通常与该二级结构中的环结构相吻合。与断点周围的互补序列一起,这将允许这些序列不配对,从而使互补序列作为潜在的引物结合并允许使用引发-重组方法来重新启动转录。聚合酶在“供体”侧似乎不稳定,复制被中断,直到聚合酶可以使用互补引物重新附着在基因组的不同位置(“受体”)并继续转录,导致内部缺失。
图19:EV71 DVG序列:SEQ ID NO:1(DG1:EV71 DVG 293-390)、SEQ ID NO:2(DG2:EV71 DVG 294-404)、SEQ ID NO:3(DG3:EV71 DVG 1746-2895)、SEQ ID NO:4(DG4:EV71DVG 1752-2894)、SEQ ID NO:5(DG5:EV71 DVG 1752-2896)、SEQ ID NO:6(DG6:EV71 DVG1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQ ID NO:8(DG8:EV71 DVG 3513-6516)、SEQ ID NO:9(DG9:EV71 DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG 5610-6876)、SEQ ID NO:11(DG11:EV71 DVG 5610-6877)、SEQ ID NO:12(DG12:EV71 DVG 5746-5821)、SEQ ID NO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71 DVG 6322-6358)、SEQ ID NO:15(DG15:EV71 DVG 6728-6779)、SEQ ID NO:16(DG16:EV71 DVG 6966-7012)、SEQ ID NO:17(DG17:EV71 DVG 6966-7014)、SEQ ID NO:18(DG18:EV71 DVG 7098-7122)、SEQ ID NO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71 DVG 7165-7201)和SEQ ID NO:21(DG21:EV71 DVG 7238-7292)。
下表列出了EV71 DGV序列。
SEQ ID NO | 病毒 | 名称 | DVG大小 | 图 |
1 | EV71 | 293-390 | 7334 | 图19 |
2 | EV71 | 294-404 | 7321 | 图19 |
3 | EV71 | 1746-2895 | 6282 | 图19 |
4 | EV71 | 1752-2894 | 6289 | 图19 |
5 | EV71 | 1752-2896 | 6288 | 图19 |
6 | EV71 | 1880-6487 | 6288 | 图19 |
7 | EV71 | 1880-6488 | 2823 | 图19 |
8 | EV71 | 3513-6516 | 4428 | 图19 |
9 | EV71 | 5475-5634 | 7272 | 图19 |
10 | EV71 | 5610-6876 | 7165 | 图19 |
11 | EV71 | 5610-6877 | 7164 | 图19 |
12 | EV71 | 5746-5821 | 7356 | 图19 |
13 | EV71 | 6322-6356 | 7397 | 图19 |
14 | EV71 | 6322-6358 | 7395 | 图19 |
15 | EV71 | 6728-6779 | 7380 | 图19 |
16 | EV71 | 6966-7012 | 7385 | 图19 |
17 | EV71 | 6966-7014 | 7383 | 图19 |
18 | EV71 | 7098-7122 | 7407 | 图19 |
19 | EV71 | 7165-7200 | 7396 | 图19 |
20 | EV71 | 7165-7201 | 7395 | 图19 |
21 | EV71 | 7238-7292 | 7377 | 图19 |
图20:EV71 DI候选共转染
优选的EV71 DVG选自由以下组成的组:SEQ ID NO:1(EV71 DVG 293-390,DG1)、SEQ ID NO:3(EV71 DVG 17646-2895,DG3)、SEQ ID NO:14(EV71 DVG 6322-6358,DG14)、SEQ ID NO:15(EV71 DVG 6728-6779,DG15)、SEQ ID NO:18(EV71 DVG 7098-7122,DG18)和SEQ ID NO:21(EV71 DVG 7238-7292,DG21)。
EV71 TIP候选体外抑制野生型病毒
将含有293T细胞的24孔板接种,第二天达到约90%的融合度。将200ng的pCAGGS-EV71_Sep006单独转染或使用对照质粒(pcDNA3-RFP)或单独的DVG进行转染。其他质粒与野生型EV71回收质粒以1:1、5:1或10:1(DVG:WT)的摩尔浓度比混合。转染以四次重复进行。使用Lipofectamine 2000(Life Technologies)转染质粒,6小时后更换培养基,转染后4天收集样本。病毒滴度通过TCID50或通过空斑测定法(plaque assay)进行评估。简而言之,对于TCID50,用Vero细胞和连续稀释的病毒上清液接种96孔板,将其冻融两次,加入样本并在37℃和5% CO2下培养7天。对于空斑测定法,使用在感染前24小时接种VeroE6细胞的24孔板中滴定病毒。将10倍连续稀释的病毒样本培养1小时后,使用2% FBS(LifeTechnologies)、MEM(LifeTechnologies)和0.05% Agarose(Thermo)将细胞用半固态琼脂糖覆盖层覆盖。将该板在37℃和5% CO2下培养72小时。对于这两种方法,用4%福尔马林固定的细胞和斑块都使用结晶紫进行可视化。
实施例3:寨卡病毒(ZIKV)
寨卡病毒中出现的所有DVG的生成和表征
方法:用于识别DVG的病毒是寨卡病毒(ZIKV)的非洲毒株MR766。为了识别DVG,ZIKV在Vero、BHK或C6/36细胞中以高感染复数传代。简而言之,接种达到70-80%融合度的细胞用5PFU/细胞的初始MOI感染。感染后3(Vero,BHK)或5(C6/36)天,细胞培养上清液通过离心澄清,300ul上清液用于感染幼稚细胞(第2代)。对于低MOI条件,3ul病毒上清液用于后续传代中的感染。所述传代重复12次。从澄清的上清液(TRIzol)中提取RNA并用于新一代测序。使用RNA文库制备试剂盒(Illumina)制备的文库被加载到Illumina NextSeq500测序仪上,使用150次循环单端读数。使用上述计算管道分析获得的读数。
样本的深度测序和计算分析确定了整个基因组中的所有缺失热点和群中出现的特定DVG。在图21中,每个图表示不同的传代数,而每个图中的每一行是不同的生物复制,在BHK细胞中进行。分析显示了几次复制共有的缺失热点,表明这些DVG比许多其他携带随机缺失的DVG具有更高的适应度。缺失也发生在传代之中,这表明相应的DVG具有更高的适应度,可以被包装以感染新细胞。在图22中,对在Vero细胞中传代的病毒进行了相同的分析。数据显示,虽然在最初的传代中,在BHK细胞中也发现了一些缺失和DVG,但某些缺失热点(在基因组的5’端)是该细胞系所独有的,并且在频率方面取代了其他缺失。在图21中,缺失热点显示ZIKV基因组5’端的缺失区域,其与在Vero细胞中观察到的模式(pattern)相似。总而言之,该数据显示了使用多于一个细胞系或宿主来确定DVG在不同条件下的总宽度和整体适应度的重要性。图24示出了在不同细胞类型中发现的常见和独特DVG的进一步比较,其中比较了在Vero(左图)和C6/36(右图)中生长的寨卡病毒。该图强调了细胞类型之间存在许多差异,但也揭示了随着传代系列的进行,两种细胞类型中均出现的一簇缺失(表明这些DVG的高适应度)。
从这些和其他分析中,我们根据我们的选择标准选择了一系列TIP候选。候选者被命名为A、B、C、D、E、F、G、H、K和L。候选者跨越各种大小,并且缺失发生在基因组的不同位置,代表相比于使用常规传代和分离可识别的更广泛的TIP候选。
图21.BHK-21细胞中的DVG识别。对各代的ZIKV种群进行深度测序(RNAseq),并且整个ZIKV基因组中每个缺失的核苷酸位置(x轴)的归一化频率显示为热图。每个图代表所有高MOI复制的不同传代数。每个图中的每一行代表12次生物复制中的一次。
图22:Vero细胞中的DVG识别。对各代的ZIKV种群进行深度测序(RNAseq),并且整个ZIKV基因组中每个缺失的核苷酸位置的归一化频率显示为热图。每个图代表所有高MOI复制的不同传代数。
图23:C6/36细胞中的DVG识别。对各代的ZIKV种群进行深度测序(RNAseq),并且整个ZIKV基因组中每个缺失的核苷酸位置的归一化频率显示为热图。每个图代表所有高MOI复制的不同传代数。
图24:ZIKV DVG热点的识别。为Vero(A)和C6/36(B)细胞传代绘制了缺失的起始(x轴)和终止(y轴)位置。数据点根据传代数着色。在起始和终止位置为约500-3000nt起始-终止的区域中观察到明显的热点,特别是在Vero细胞中。
图25:候选ZIKV DVG的示意图。ZIKV候选DVG的选择是基于它们在整个传代过程中的冗余度和频率。左边的每个字母代表DVG的临时名称。
寨卡病毒TIP候选K本身是不可复制的
方法:基于DG K的复制子构建体设计用于评估DG的复制能力。Nanoluc报告基因构建体生成,其中所述报告基因插入代替结构蛋白,如通常为黄病毒复制子设计的(图29A)。RNA通过体外转录由DNA克隆生成,并转染到Vero细胞中。在转染后6、24、48和72小时,在细胞中测定nanoluc报告基因活性。
结果表明,与随时间推移观察到报告基因活性增加的WT复制子不同,DG K复制子未显示增加(图29B)。然而,当在感染的细胞中重复该测定时,复制子活性恢复(图29C),表明DG本身是不可复制的,但需要WT进行DG的复制。这些结果对使用DVG作为潜在TIP的安全性具有重要意义。
图27.ZIKV DG本身是不可复制的并依赖于WT进行复制。(A)复制子构建体示意图。对于野生型复制子,C38和E30分别代表C的N-末端38个氨基酸和E蛋白的C-末端30个氨基酸。对于DG复制子,Pr38和NS198分别代表Pr和NS1蛋白的N-末端38个氨基酸和C-末端98个氨基酸。Nanoluc2A代表nanoluc报告基因序列后接有手足口病病毒2A蛋白酶。还构建失活突变复制子(NS5ΔGDDAAA复制子)。(B)野生型和DG复制子测定。等量的野生型、NS5ΔGDDAAA和DG复制子RNA在Vero细胞中转染,并在转染后的指定时间测量相对光单位(RLU)。(C)感染或未感染细胞中的DG复制子测定。将等量的DG复制子RNA转染到幼稚或感染的Vero细胞(MOI1PFU/细胞)中,并在转染后的指定时间测量相对光单位(RLU)。野生型和NS5ΔGDDAAA复制子作为对照进行。所有图表均显示平均值和标准差(SD);对于代表性实验,每组n=3,并将每组内的时间点与4小时的RLU值进行比较。进行了使用Dunnet多重比较检验的双向ANOVA(*=p≤0.05,**=p≤0.01,***=p≤0.001,****=p≤0.0001)。
寨卡病毒TIP候选体外抑制野生型病毒
方法:HEK293T细胞用编码野生型ZIKV或候选DVG的质粒以增加的摩尔比(1:10、1:1或10:1的DVG:WT比率)转染。转染后4天,通过空斑测定法确定病毒滴度。
体外测试了上述确定的候选TIP抑制野生型寨卡病毒的能力。用编码寨卡病毒的质粒以及编码每个DVG的质粒以增加的摩尔比转染细胞。通过测量处理后子代病毒的量来确定TIP候选对WT病毒生长的影响。数据(图28)显示,在最高比率下,除DG-G或框外DG-H之外的所有TIP候选都具有至少轻微的抑制作用;而DG-C、DG-D、DG-E、DG-F、DG-K和DG-L将病毒滴度降低1log或更多。该结果还揭示了抑制的剂量依赖性。
图26:候选DVG体外抑制ZIKV复制。HEK293T细胞用编码ZIKV候选DVG的质粒和野生型编码质粒以增加的摩尔比(1:10、1:1或10:1的DVG:WT)转染。转染后4天,采集细胞培养上清液,并通过空斑测定法确定ZIKV滴度以确定候选DVG是否具有干扰作用。进行了使用Dunnet多重比较检验的双向ANOVA(*=p≤0.05,**=p≤0.01,***=p≤0.001,****=p≤0.0001)。将每种情况与仅用野生型病毒转染的细胞进行比较。
寨卡病毒TIP候选体内抑制野生型病毒。
小鼠方法:AG129雄性小鼠(4-6周龄)用104PFU的寨卡病毒感染并用20ug编码DG-E、DG-H或DG-K的质粒共转染(表现出体外最高抑制作用的候选DVG),使用体内-jetPEI转染试剂(Polyplus),通过爪垫注射(皮下注射(s.c.)),总体积50ul。对照小鼠接受不编码任何TIP的对照质粒。通过体重减轻监测TIP减轻感染的能力。此外每天测量病毒血症(第5天除外)。感染后7天,对小鼠实施安乐死,并对脾、脑和睾丸(tested)进行解剖,以测定这些器官中的病毒滴度。
结果显示(图28A)所有三种TIP保护小鼠免于体重减轻,而接受对照质粒的小鼠在第7天体重明显减轻。我们监测了TIP治疗对病毒血症的影响(图28B)。数据显示,所有接受对照质粒的三只小鼠早在感染后第2天就在血液中具有高水平的病毒。接受DG-E或DG-H的3只小鼠中有2只没有病毒血症,而每组中的一只小鼠病毒血症延迟1-2天。接受DG-K的小鼠没有任何病毒血症。然后,我们在第7天测定了小鼠脑、睾丸(testes)和脾中的病毒滴度(图28C)。接受对照治疗的所有小鼠的每个器官中都具有非常高的滴度。在图33B中呈现延迟性病毒血症的小鼠的脑中显示出降低的滴度,而在其他器官中显示出相似的滴度。所有其他小鼠都受到完全保护,其任何组织中都未检测到病毒。
图28:ZIKV候选DVG-E、DVG-H和DVG-K保护AG129小鼠免受ZIKV感染。AG129小鼠(雄性,5-6周)注射了20ug的DVG编码质粒(或模拟质粒对照)于转染混合物中和104PFU的ZIKV的混合物。(A)每天监测体重减轻。只有用模拟质粒转染的小鼠在7天后体重减轻。(B)每天跟踪病毒血症。虽然用模拟质粒转染的小鼠表现出相似的病毒血症特征,但只有三分之一的小鼠表现出DVG-E和DVG-H的延迟病毒血症。所有其他小鼠(包括用DG K转染的小鼠)在任何时间点均未出现病毒血症。(C)注射(p.i.)后7天对小鼠实施安乐死并收集脑、睾丸和脾。仅在表现出病毒血症的小鼠中检测到感染性病毒。
VLP包装方法:使用TransIT-mRNA转染试剂(Mirus Bio),用100ng DVG复制子RNA、WT复制子(阳性对照)或失活复制子(阴性对照)转染24孔板中未感染或感染的Vero细胞(生产细胞,24h时的MOI 1PFU/细胞)。转染后(p.t.)48小时,上清液经核酸内切酶处理(25单位/μl BaseMuncher,Expedeon)并用于感染24孔板中的幼稚Vero细胞(受体细胞)。注射后(p.i.)24小时,评估受体细胞中的复制子活性。在被动裂解缓冲液(Promega)中裂解供体和受体细胞,并在Tecan infinite M200 pro读板仪(Tecan group)中使用Nano-Glo荧光素酶测定系统(Promega)测量荧光素酶活性。接种于24孔板中的HEK-293T细胞用200ng CPrME编码质粒、200ng E30-NS1和200ng DVG编码质粒(LT-1转染试剂,Mirus Bio)的混合物转染。转染后(p.t.)72h,通过离心澄清培养基。在核酸内切酶(Basemuncher,Expedeon)处理后,N个幼稚受体细胞(Nrecipient cells)用生产细胞上清液感染,使用报告基因DVG克隆时通过荧光素酶测量确定成功包装,或使用天然DVG时通过RT-qPCR确定成功包装。
小鼠中的VLP-DVGs方法:通过腹膜内注射给予4-6周龄AG129或C57BL/6雌性小鼠氯胺酮(10mg/mL)/甲苯噻嗪(1mg/mL)混合物。麻醉后,通过皮下(爪垫)途径用载体(DMEM培养基)给小鼠接种104PFU单独寨卡病毒,或补充有含DVG的VLP(TIP)的寨卡病毒。C57BL/6小鼠在感染前一天通过腹膜内注射2mg的IFNAR1阻断小鼠MAb(MAR-5A3,Euromedex)进行治疗。在感染后的指定时间监测体重减轻和病毒血症。从面部静脉收集血液到Microtainer采血管(BD)中并使其在室温下凝结。血清通过离心分离并储存在-80℃下。如前所述19,病毒血症通过空斑测定法或RT-qPCR对未提取并稀释的血清样本进行量化。感染的小鼠通过颈椎脱臼进行安乐死。使用Precellys24均质器(Bertin Technologies)在5000rpm下进行20秒的2次循环,采集脾、卵巢、脑和注射的爪垫,并在含有陶瓷珠的Precellys管中用600μl补充有2%FBS的DMEM进行均质化。通过离心清除匀浆,并将上清液储存在-80℃下直至病毒滴定或RT-qPCR。在使用Direct-zol-96(Zymo)提取RNA后,通过空斑测定法(表示为PFU/g器官)或通过RT-qPCR(表示为相对于GAPDH的PFU当量)测量器官中的病毒载量。将小鼠器官中DVG或WT RNA基因组的数量标准化为GAPDH基因组,该基因组来自使用小鼠GAPDH引物(补充表1)和从未感染小鼠的相应器官中提取的RNA的标准曲线。
图29.生成携带DVG-A的病毒样颗粒。(a)WT病毒对DVG-A包装能力的评估。用WT复制子、失活复制子、DVG-A报告基因或DVG-A框外报告基因RNA转染感染或未感染的细胞。转染后48小时,从供体细胞采集细胞上清液,去除裸RNA,并用于感染幼稚受体细胞,24小时后采集用于测量报告基因活性。示出了受体细胞中的荧光素酶活性。****=p≤0.0001(与未感染的细胞相比,通过使用Dunnet多重比较的双向ANOVA)(b)VLP测定示意图:用CPrME、E30-NS1和DVG编码质粒转染HEK-293T细胞。转染后72小时,采集具有含DVG的VLP的细胞培养上清液。(c)使用WT复制子和DVG-A报告基因的VLP测定。用带有或不带有(模拟)CPrME和E30-NS1的WT复制子或DVG-A报告基因质粒转染供体细胞。用核酸酶处理细胞培养上清液并用于感染幼稚受体细胞。示出了受体细胞中的报告基因活性。****=p≤0.0001(与模拟条件相比,通过使用Dunnet多重比较的双向ANOVA)。(d)量化使用天然DVG-A生成的VLP中的DVG-A基因组。使用RT893 qPCR对来自供体细胞的澄清且经核酸酶处理的上清液进行DVG-A定量。阴性对照是指在不存在CPrME或E30-NS1的情况下,来自用相同数量的含有DVG-A的质粒转染的细胞的上清液。***:p=0.0004(通过双尾t检验)。所有图表均显示平均值和SD;对于三组实验的一个代表性实验,每组n=3。
图30.包装测定生产细胞中的报告基因活性。(a)用WT复制子、失活复制子、DVG-A报告基因或DVG-A框外报告基因RNA转染感染或未感染的Vero细胞。转染后48小时,从生产细胞采集细胞上清液,去除裸RNA,并用于感染幼稚受体细胞(如图4a所示)。示出了生产细胞中的报告基因活性。***:p=0.0004,****=p≤0.0001(与未感染的细胞相比,通过使用Dunnet多重比较的双1011向ANOVA)。(b)使用WT和DVG-A报告基因的VLP测定。用带有或不带有(模拟)CPrME和E30-NS1的WT或DVG-A报告基因转染供体细胞。用核酸酶处理细胞培养上清液并用于感染幼稚细胞。示出了生产细胞中的复制子活性(转染后72h)。****=p≤0.0001(与模拟条件相比,通过使用Dunnet多重比较的双向ANOVA)。所有图表均显示平均值和SD;对于三组实验的一个代表性实验,每组n=3。
DVG-A可以包装到病毒样颗粒(VLP)中,用于体内递送。为了将DVG作为潜在的治疗剂,我们可能需要适当的递送方法。因此,我们建立了一个包装系统,以将DVG用蛋白质壳体包裹成病毒样颗粒(VLP)。我们首先必须确认该DVG能够完全用蛋白质壳体包裹。为此,我们用DVG-A报告基因或对照WT复制子RNA转染未感染或感染的细胞。这些细胞——称为“生产”细胞——应(如果为感染的)产生WT病毒后代,以及包含可被包装的基因组的病毒体(virion)。将来自感染的生产细胞的上清液转移到幼稚(受体)细胞使我们能够评估表达报告基因的基因组的包装。与不存在病毒时的背景活性相比,在存在WT病毒的情况下,在受体细胞中观察到显著更高的WT复制子和DVG-A报告基因活性,证实了DVG-A被WT病毒包装(图29a,生产细胞报告基因活性如图30a所示)。相比之下,未检测到失活复制子或DVG-A_框外的报告基因活性增加,这表明复制是基因组包装的必要条件。接下来,我们开发了一种产生VLP的系统,以在没有WT病毒的情况下将DVG-A用蛋白质壳体包裹起来。简而言之,我们用编码DVG-A、结构蛋白(CPrME)和非结构蛋白NS1的质粒转染细胞,以分别实现DVG-A的包装和复制(图29b)。然后在将上清液转移到幼稚受体细胞后,评估将DVG-A向VLP中的包装。使用报告基因DVG-A,我们证实了包装的DVG-A在受体细胞中的报告基因活性与包装的WT复制子相当(图4c,图30b中示出生产细胞报告基因活性)。最后,我们证实了天然DVG-A被包装到VLP中,如转染的细胞上清液的RT-qPCR所示(图29d)。因此,DVG-A可有活性地包装到VLP中,所述VLP可作为治疗干扰粒子(therapeutic interfering particles,TIP)用于体内评估。
图31.携带寨卡病毒DVG-A的TIP抑制在小鼠中的病毒复制。(a)实验设计。4-6周龄AG129或C57BL/6雌性小鼠(n=5)接种在DMEM中稀释的WT病毒、模拟TIP上清液(来自没有结构蛋白的转染)或确认含有DVG包装VLP(TIP)的上清液。C57BL/6小鼠在感染前24小时用2mg的IFNAR1阻断单克隆抗体处理。在感染后的不同时间,采集血清。注射后(p.i.)6天,对小鼠实施安乐死并采集器官。(b-e)AG129小鼠:(b)感染小鼠的体重减轻以第0天体重的百分比表示。**:p=0.011;****:p≤0.0001。(c)感染后第2、4和6天的病毒血症。***:p=0.0007;****=p≤0.0001。(d)注射爪垫、脾、卵巢和脑中的病毒载量,注射后(p.i.)6天。****=p≤0.0001。(e)通过RT-qPCR测量所采集的所有器官中的DVG量。(f-h)C57BL/6雌性小鼠在感染前24小时给予IFNAR1-阻断单克隆抗体。(f)注射后(p.i.)3天和6天,通过RT-qPCR测量病毒血症并以PFU当量/mL进行描述。****=p≤0.0001。(g)注射后(p.i.)6天,对小鼠实施安乐死,并通过RT-qPCR测量器官中的病毒载量。****=p≤0.0001。(h)通过RTqPCR测量的所有器官中的DVG-A量。在所有情况下,进行了使用Dunnet多重比较的双向ANOVA,将每种情况与仅感染WT病毒的小鼠进行了比较。
寨卡病毒VLP-DVG降低小鼠的感染和毒性。我们接下来评估了这些包装为VLP的DVG作为小鼠抗病毒措施的功效。我们使用缺乏α/β和γ受体的小鼠(AG129小鼠),因为它们对寨卡病毒感染和疾病进展高度敏感。对小鼠进行模拟感染(仅载体),仅用104PFU WT病毒感染,或用WT病毒和DVG-A的混合物感染。使用每个寨卡病毒感染性病毒体约10个DVG-A基因组拷贝。作为另外的对照,小鼠接受了来自模拟生产条件的WT病毒和上清液的混合物(“对照TIP”,在没有CPrME或NS1的情况下生成)(图31a)。除模拟感染的小鼠外,所有小鼠在第6天体重减轻。此时,经TIP处理的(而非对照的经TIP处理的)小鼠的体重减轻明显少于WT病毒感染的小鼠(图31b)。此外,与仅接受WT病毒或对照处理的小鼠不同,经TIP处理的小鼠在注射(p.i.)后第2、4和6天表现出显著降低的病毒血症,病毒滴度差异最高达2-log(图31c)。在第6天,在TIP处理的小鼠中,爪垫、脾、卵巢和脑中的病毒载量也降低了1-2log,强调了该TIP的保护作用(图31d)。虽然循环血液中的DVG-A RNA低于检测水平,但我们证实了在经TIP处理的小鼠的爪垫中存在DVG-A RNA,并且在脾、卵巢和脑中含量较低(图31e)。这些结果证实了DVG-A TIP成功地从注射部位传播到远端器官。为进一步支持,我们在免疫能力更强的小鼠模型中评估了TIP功效。C57BL/6小鼠在感染寨卡病毒之前用IFNAR1-阻断单克隆抗体处理,使用或不使用TIP。未监测到体重减轻,因为在这些条件下小鼠既不会减轻体重也不会死于感染。在注射(p.i.)后第3天和第6天,经DVG处理的小鼠的病毒血症显著降低(图31f)。虽然我们没有观察到爪垫或脾中病毒载量的差异,但与对照条件相比,TIP处理的小鼠的卵巢和脑中的病毒载量显著降低,病毒载量差异最高达2-log(图31g)。正如在AG129小鼠中所注意到的,注射部位的大量DVG-A传播至经TIP处理的小鼠的脾、脑和卵巢中(图31h)。
蚊子试验方法:使用Cellfectin转染试剂(对照RNA、DG H或DG K)向埃及伊蚊(Ae.aegypti)注射0.02皮摩尔RNA。注射后2天,给蚊子喂食含有7X105pfu/mL ZIKV的血餐(bloodmeal)。通过在感染后第8或13天解剖蚊子身体部位并测定病毒载量来监测TIP减轻感染的能力。在注射(p.i.)后第13天,还使蚊子进行唾液分泌,以研究在TIP的存在下是否可阻断传播。
结果表明,在注射(p.i.)后13天的蚊子全身中,在注射DG H和DG K的蚊子中病毒载量显著降低,这表明在TIP的存在下蚊子中的病毒衰减(图32A)。在注射(p.i.)后第8天,在对照、注射DG H或DG K的蚊子中,总体感染率未受到影响,尸体中的感染率受到显著影响(图32B),这表明DG减弱了蚊子中的病毒传播。此外,虽然所有条件下的中肠滴度相似,但在尸体中呈阳性的仅有的阳性蚊子达到的滴度低于注射对照RNA的蚊子中的滴度(图32C)。最后,在注射(p.i.)后第13天,9只注射对照RNA的蚊子中有7只在唾液中呈ZIKV阳性(因此可能传播病毒),对于注射DG H的蚊子,没有唾液呈阳性(n=13),对于注射DG K的蚊子,16只蚊子中有一只呈阳性(图32D)。
图32:ZIKV DG H和DG K抑制实验感染蚊子的病毒复制、传递和传播。对埃及伊蚊被注射0.02皮摩尔RNA。注射后2天,给蚊子喂食含有7X105pfu/mL ZIKV的血餐,并在注射(p.i.)后第8或13天进行解剖。(A)注射(p.i.)后第13天,预注射对照(n=8)、框外DG(n=11)或框内DG(n=10)RNA的蚊子全身病毒载量。(B)注射(p.i.)后第8天,在预先注射对照(n=6)、框外DG(n=10)或框内DG(n=10)的蚊子的中肠或尸体中ZIKV感染的感染率。(C)(B)中相同蚊子的中肠或尸体中的病毒载量。(D)注射(p.i.)后第13天,在预先注射对照(n=9)、框外DG(n=13)或框内DG(n=16)的蚊子中ZIKV阳性唾液的百分比。框外DG=DG H;框内DG=DG K。
已识别的ZIKV序列列于图40。
ZIKV DVG序列选自由以下组成的组:SEQ ID NO:22(ZIKV DVG-A)、SEQ ID NO:23(ZIKV DVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ ID NO:26(ZIKV DVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ ID NO:29(ZIKV DVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ ID NO:32(ZIKV DVG-K)和SEQ ID NO:33(ZIKV DVG-L)。
优选的ZIKV DVG序列选自由以下组成的组:SEQ ID NO:22(ZIKV DVG-A)、SEQ IDNO:24(ZIKV DVG-C)和SEQ ID NO:25(ZIKV DVG-D)。
最优选的ZIKV DVG序列选自由以下组成的组:)、SEQ ID NO:26(ZIKV DVG-E)、SEQID NO:32(ZIKV DVG-K)、SEQ ID NO:33(ZIKV DVG-L)和具有以下特征的簇内的其他可能的DVG;缺失导致起始位点在ZIKV基因组的500和900nt之间且缺失的终止位点在2800和3400nt之间的框内缺失事件。
实施例4:基孔肯雅病毒(CHIKV)
在本实施例中,我们记录并描述了在体外和体内基孔肯雅病毒感染期间产生的带有缺失的天然存在的DVG。从这些DVG中,我们选择了最有可能具有干扰能力的DVG,这是基于它们的复制之间的频率和重复出现率和/或它们在多次传代中被携带的能力。我们示出了天然DVG在体外对哺乳动物和蚊子细胞中的基孔肯雅病毒具有很强的抗病毒活性,并证明了干扰DVG可广谱对抗其他甲病毒。最后,我们表明了DVG可在感染前被引入媒介蚊以抑制虫媒病毒的传播。
Vero、Huh7、293T和BHK细胞在Dulbecco改良Eagle培养基(DMEM)中生长,该培养基含有10%胎牛血清(FCS)、1%青霉素/链霉素(P/S;赛默飞世尔(Thermo Fisher))和1%非必需氨基酸(赛默飞世尔),在37℃和5% CO2的加湿环境中培养。U4.4和Aag2细胞在28℃下保持在Leibovitz's L-15培养基中,所述培养基含有10% FCS、1% P/S、1%非必需氨基酸(Sigma)和1%磷酸胰蛋白(Sigma)。
病毒原液由源自印度洋谱系(Indian Ocean lineage)ECSA基因型(IOL;描述于17中)或源自加勒比海毒株(Caribbean strain)亚洲基因型(Asian genotype)(加勒比(Carib);描述于18中)的CHIKV感染性克隆生成。为测试DVG干扰活性,使用了在亚基因组启动子下含有Gaussia荧光素酶基因的CHIKV感染性克隆(从Andres Merits获得)。在使用脂质体2000(Invitrogen)转染BHK之前,使用SP6 mMESSAGE mMACHINE试剂盒(Invitrogen)对非I线性化质粒进行体外转录(in vitro transcription,IVT)。在Vero细胞中传代一次后,对该原液进行滴定并保持在-80℃下至使用。
在感染前24小时,对在24孔板中覆盖的融合Vero细胞进行病毒滴定。在单独DMEM中进行十倍稀释并转移到Vero细胞上。允许感染后,将具有2% FCS、1% P/S和0.8%琼脂糖的DMEM添加到细胞顶部。感染后三天,用4%福尔马林(Sigma)固定细胞,并在用0.2%结晶紫(Sigma)染色后手动计数斑块。
将细胞接种在24孔板中,以在第二天达到约80%的融合度。对于第1代,将病毒在PBS中稀释以获得5PFU/细胞(高MOI)的感染复数(MOI)。将细胞与病毒接种物在37℃下培养1小时。病毒吸附后,去除接种物,用PBS洗涤感染的细胞,并更换为含有2%(v/v)FCS的合适的细胞培养基。在感染后48-72小时,采集上清液并通过离心(12 000xg,5分钟)澄清。以下传代是盲法进行的,使用来自上一代的大量(300μl)澄清上清液感染幼稚细胞,然后进行相同的程序。总共进行了10次传代。通过空斑测定法对每一代进行滴定,以确定在哪些代DVG积累可产生干扰。每种细胞类型进行了至少3次复制。
测序。依照制造商的方案,使用TRIzol试剂(Invitrogen)或ZR病毒RNA试剂盒(Zymo)提取100ul每种样本上清液的RNA。RNA在15-30μL不含核酸酶的水中洗脱。使用Quant-iT RNA检测试剂盒(赛默飞世尔科技(Thermo Fisher Scientific))进行定量后,用NEBNext Ultra II RNA文库试剂盒(Illumina)制备RNA文库。在文库制备过程中使用了复用寡核苷酸(Illumina)。使用高灵敏度DNA芯片(Agilent)验证文库的质量,并使用Quant-iT DNA检测试剂盒(赛默飞世尔科技)进行定量。文库测序(稀释至1nM)在NextSeq测序仪(Illumina)上使用NextSeq 500Mid Output kit v2(Illumina)进行(151次循环)。
新一代测序数据分析。所有分析均使用BBTools套件(Bushnell B.-sourceforge.net/projects/bbmap/)进行。首先,使用BBDuk对从样本测序生成的fastq文件进行裁剪,以剪切低质量的碱基和接头。然后,使用BBmap和适当的CHIKV参照序列(加勒比-GenBank登录号LN898104.1,IOL-GenBank登录号AM258994)进行对齐。BBMap的变体调用者CallVariants报告了缺失事件,并且每个样本的整体DVG频率是计算为与每个DVG对应的连接读取计数(n)的总和,并归一化为5/3×n/N,其中N表示每个位置的覆盖率的98%。乘以5/3旨在校正检测限。事实上,即使读数是150个核苷酸长,对齐部分通常也只有30到120个核苷酸长。这意味着在断点上游起始30个或更少核苷酸的读取将在断点的右侧而不是左侧对齐,因此不会被视为DVG。因此,我们缺少(30+30)/150=60/150=2/5的缺失,并且计数必须乘以5/3作为校正因子。热图说明了每个核苷酸位置的缺失分数,基于移除该特定位置的缺失事件。具体而言,分数计算为支持特定核苷酸位置缺失的每百万读数的读数(RPM)总和。为了绘制起始/终止断点,舍弃长度低于10个核苷酸的缺失。
克隆选定的缺陷基因组。使用先前在体内组装(IVA)方法中所描述的19或使用In-Fusion试剂(Takara Bio Reagent),将选自传代的缺陷基因组克隆到与其菌株相对应的CHIKV感染性克隆(在SP6启动子下)中。使用SnapGene软件设计引物,解链温度为60℃,并从Integrated DNA Technology(IDT)获得。使用Phusion高保真DNA聚合酶(赛默飞世尔)或Q5DNA聚合酶(NEB)进行50μl PCR,其中Phusion酶的解链温度为57℃,Q5聚合酶的解链温度为65℃。进行18次循环,然后PCR产物经Dpn I(赛默飞世尔)处理至少2小时以去除质粒模板并纯化(Macherey Nagel PCR和凝胶纯化试剂盒)。当使用IVA技术时,根据提供的方案,将2ulPCR产物直接转化到XL10-Gold超级感受态细胞(Stratagene)中。当需要In-Fusion反应时,依照供应商的说明使用In-Fusion试剂(Takara Bio Reagent)连接PCR产物,并将1ul转化到Turbo细胞(NEB)中。
用于测试DG干扰活性的荧光素酶测定。使用来自DVG和CHIVV Carib-GLuc的非I线性化感染性克隆的SP6 mMESSAGE mMACHINE试剂盒(Invitrogen)进行IVT(见上文)。通过Qubit RNA TS测定试剂盒(赛默飞世尔)对RNA生产进行量化,并稀释至指定的相对于Carib-GLuc CHIKV的摩尔比。依照供应商的方案(每孔25ng Carib-GLuc CHIKV),用TransIT-mRNA转染试剂盒(Mirus)将混合的DVG和全基因组RNA转染到接种在96孔板中的293T或U4.4细胞中。转染后4小时更换培养基以避免细胞毒性。转染48小时后,收集上清液并与腔肠素(由Y.Janin,巴斯德研究所(Institut Pasteur)提供)混合,最终浓度为0.05μM,在Tecan Infinite 200酶标仪上测量发光。当用不表达荧光素酶的病毒进行测试时,按照相同的方式进行该程序,但在转染后48小时通过空斑测定法对上清液进行滴定。
RT-qPCR检测DVG自我复制。如上所述,将50ng DVG或CHIKV Carib IVT转染到293T细胞中(前一天接种在48孔板中),一式三份。转染后8小时,去除上清液,用PBS洗涤细胞3次,然后加入新鲜培养基。在转染后8、20、28和44小时,将来自ZR 96病毒RNA试剂盒(Zymo)的200ul裂解缓冲液添加到去除上清液后的细胞上,并在-20℃下储存,直至收集了所有的时间点。用ZR 96病毒RNA试剂盒提取细胞RNA,并洗脱15μl。TaqMan RNA-to-Ct一步法RT-PCR试剂盒(美国应用生物系统公司(Applied Biosystems))用于进行跨越5’UTR-nsP1区域的定量RT-PCR,以5’-GAGACACACGTAGCCTACCA-3’作为正向引物,5’-GGTTCCACCTCAAACATGGG-3'作为反向引物,5’-[6-FAM]ACGCACGTTGCAGGGCCTTCA-3’作为探针。在50℃下20分钟和95℃下10分钟后,进行40次循环(95℃下15秒,然后60℃下1分钟)。
蚊子。雌性埃及伊蚊,其属于从甘榜省(泰国)(Kamphaeng Phet Province(Thailand))采集的野生蚊子的第7代,在28℃、70%相对湿度和12小时光照条件下生长:12小时黑暗循环,喂食10%蔗糖。喂血前一天,选择6至10天大的雌性并饥饿一天。含有106PFU/ml CHIKV的血餐通过设置在37℃下的膜饲喂系统(Hemotek Ltd)提供给一群60只雌性,该系统以一块脱盐猪肠作为膜。在血餐之后,选择完全饱血的雌性并在28℃、70%相对湿度和12小时光照下培养:12小时黑暗循环,随意食用(permanent access)10%蔗糖。7天后,将蚊子处死并解剖,收集头、胸、中肠、腿和翅(腿/翅)、腹壁(身体)。用QiagenTissuLyser 2机器将每个器官在300ul补充有2% FBS的L15中研磨,然后在滴定前通过离心澄清,并用TriZol试剂提取RNA进行RNA深度测序。将通过体外转录(如上所述)产生并通过苯酚-氯仿纯化的150纳克RNA与Leibovitz's L-15培养基和Cellfectin II试剂(赛默飞世尔)依照供应商的说明进行混合。对于每种情况,使用Nanoject III纳升级注射器(Drummond scientific company)向40只6至8天大的雌性胸内注射300nl的该混合物。两天后,经过一夜的饥饿,向蚊子喂食如上所述的106PFU/ml CHIKV Carib-GLuc的感染性血餐。5天后处死蚊子;如前所述,对中肠和尸体进行解剖和研磨。然后测试每个样本的荧光素酶活性并通过空斑测定法进行滴定。
缺陷病毒基因组(DVG)通过体外高MOI传代的生成。为了捕获可能在细胞培养中出现的缺失DVG,基孔肯雅病毒加勒比海毒株(CHIKV Carib)在哺乳动物(Vero,Huh7)和蚊子(Aag2,U4.4)细胞中在三份复制中(in triplicate)以高MOI连续传代。在每次传代时从每份复制的澄清上清液中提取RNA,并进行RNA深度测序。使用Bbmap管道分析读取,以通过识别包含缺失的序列读取来描述和量化DVG。正如预期,在所有细胞类型中,第一次和最后一次传代之间的DVG数量增加了1至5个数量级,并且每种细胞类型的速率和振荡不同(图33A)。
体外生成的DVG的表征。接下来,我们汇集了每种细胞的所有传代和复制的数据,以识别不同细胞类型中的潜在缺失热点。得到的热图(图33B)揭示了每个核苷酸位置缺失的频率(无论缺失的总长度是多少),其中x轴表示基孔肯雅病毒全基因组的核苷酸位置。每行代表不同的细胞类型。我们观察到细胞类型之间缺失频率较高的区域存在明显差异,这表明同一病毒株会根据宿主环境产生不同的缺失变体。在Vero和Huh7细胞中,在跨越非结构蛋白nsP1-nsP2的区域中缺失丰富,但与Vero细胞相比,HuH7中的热点轮廓更短。在Aag2细胞中,缺失核苷酸的概率在整个基因组中分布得更广泛。与其他细胞系(缺失出现在基孔肯雅病毒基因组的前半部分中)相比,在U4.4细胞中生成的DVG更经常在基因组的后半部分(从核苷酸6000[nsP3]至11500[3’UTR])中表现出缺失。值得注意的是,CHIKV IOL(印度洋谱系)毒株的相同实验具有与Vero和Aag2细胞中的CHIKV加勒比毒株相似的缺失谱。然而,CHIKV IOL缺失在Huh7(其中最强的热点是从核苷酸9000[E2]至11000[3’UTR])和U4.4细胞(在这种情况下其轮廓与在Aag2细胞中获得的轮廓相似)中存在很大差异(图33B)。总之,这些结果表明病毒株以及细胞环境都会影响体外传代过程中DVG的生成和保持。为了可视化这些病毒种群中不同的DVG,绘制了缺失>100个核苷酸的单个DVG的具体起始(x轴)和终止(y轴)断点(图33C)。分析显示了三个主要的DVG形成簇(簇A、B和C),基于在所有细胞类型中观察到的缺失的位置和大小,而第四簇(簇D)在蚊子细胞中更显著。簇A在nsP1和nsP2基因之间呈现约2500nt的相对较小的缺失。簇C从nsP2末端至3’UTR起始呈现超过9000nt的大缺失,而对于簇B,更大的缺失跨越nsP1至3’UTR。在伊蚊细胞(Aag2和U4.4)中,但在哺乳动物细胞中较少,存在另外的簇D,其在nsP3至3’UTR之间缺失约5000nt。
基孔肯雅DVG在蚊子体内的生成。为了观察蚊子体内感染期间是否也会生成DVG,我们给埃及伊蚊喂食含有106PFU/ml基孔肯雅病毒加勒比海毒株的感染血餐。使感染在7天内在所有蚊子中传播后,我们处死并解剖了其中的10只以收集单个器官:中肠、腹壁(身体)、胸、头和腿/翅(图34A)。提取RNA并测序,并使用Bbmap管道分析数据。DVG起始和终止位置的图显示与Aag2细胞中生成的数据相似的模式(图34C),具有四个不同的簇(图34B)。在10只中的两只蚊子(图34C)中,我们在几个器官(一只蚊子的中肠、身体、头和腿/翅,以及另一只蚊子的中肠、身体和头)中发现了相同的DVG(命名为CM1)。没有其他蚊子含有该DVG-CM1,也没有用来感染它们的病毒原液含有该DVG-CM1。这些结果表明DVG很容易在蚊子宿主中生成,并且它们具有与在细胞培养中观察到的相似的缺失谱。
基孔肯雅DVG候选是不可复制的。我们在前几节中的目标是发现在病毒感染期间生成的所有可能的DVG,并从数百种单独的DVG中向下筛选出那些最有可能与野生型病毒有效竞争的DVG。换言之,确定全部DVG中的哪一种是最有效的缺陷干扰粒子。我们的理由是,该DVG在高MOI传代时会更频繁地出现,并且随着DVG与野生型病毒竞争资源,其随着时间的推移会增至更高的频率。因此,DVG的选择基于表明与野生型竞争者相比具有更高适应度的标准:具有高频率,在整个传代系列中保持并在多次复制中出现。除了携带从核苷酸2695(nsP2中间)至核苷酸5358(nsP3末端)的缺失的DVG-CM1(图35A),我们从CHIKV加勒比(如上所述)和CHIKV IOL的细胞传代深度测序数据中选择了另外19种DVG并进行克隆。选择了来自所有四个簇的代表(图35A)。我们根据DVG的来源病毒株(C代表CHIKV Carib,I代表CHIKVIOL)和生成它们的细胞(V代表Vero,H代表Huh7,A代表Aag2且U代表U4.4,M代表蚊子体内)来命名DVG。它们的基因组组成如图35A所示,它们的确切缺失列于表1。另外三个候选者不属于任何定义的簇,但在几次复制中以高频率存在,并在整个传代中保持(表1)。为确认所选的DVG确实是缺陷基因组,在没有病毒的情况下无法自我复制,我们转染了在293T细胞中每种DVG或野生型病毒的体外转录的RNA。我们在转染后8、20、28和44小时采集每个DVG转染的或对照转染的细胞,从该细胞中提取RNA并进行RT-qPCR。与在整个时间点具有增加的RNA拷贝数的CHIKV Carib全长病毒RNA不同,所有DVG RNA拷贝数都随着时间的推移而减少,这反映了转染RNA的逐渐降解,并证明没有候选DVG可以自我复制(图38)。
基孔肯雅DVG体外干扰野生型病毒。我们接下来测试了来自哺乳动物细胞培养物(图39B)或哺乳动物细胞中的蚊子宿主环境(图39C)的20种DVG的干扰活性。我们选择了293T细胞,因为它们具有高转染性,并选择了在亚基因组启动子(CHIKV Carib-Gluc)下表达Gaussia荧光素酶的CHIKV加勒比病毒作为快速定量的靶病毒。为了测试源自哺乳动物或蚊子细胞培养物的DVG,用对应一种目标DVG的体外转录的RNA(或对照RNA)与CHIKV Carib-Gluc全长病毒RNA的混合物(摩尔比为1:1或10:1)转染293T细胞。在48小时采集上清液以测定荧光素酶活性作为野生型病毒复制的替代测定,因为滴度和发光相关(图39)。在1:1的摩尔比下,大多数DVG不会降低野生型病毒荧光素酶表达,但IV1和IH1的转染显示出中度的降低(p<0,05)。然而,将DVG RNA的量增加到CHIKV Carib-Gluc RNA的10倍,几乎在每种情况中都将病毒复制显著抑制了1至3个数量级(图34B和34C)。值得注意的是,具有最大缺失的最小DVG(来自簇B的CH2和CH3)在DVG:CHIKV Carib-Gluc摩尔比最高时没有或几乎没有干扰活性,其减少不到1log(图35B)。这些结果表明,当外源引入时,源自哺乳动物或蚊子细胞培养物的DVG可以抑制哺乳动物细胞中的病毒复制。
为了确定这些哺乳动物和蚊子细胞衍生的DVG是否也可以抑制蚊子细胞中的病毒复制,我们在白纹伊蚊(Aedes albopictus)细胞(U4.4)中重复了该实验。对于293T细胞,在1:1的摩尔比下没有观察到干扰;但是,除IV4外,所有先前在哺乳动物细胞中抑制病毒的DVG在10:1的比例下都观察到了相当大的抑制作用,其中荧光素酶活性降低了1至2log。如在293T细胞中所见,在蚊子细胞中没有观察到DVG CV3的干扰(p>0,05)(图35D),DVG CV3和CH3是20种DVG候选中仅有的两种在任何情况下都无法抑制病毒的DVG。另一方面,大部分可以抑制293T细胞中的病毒的蚊子细胞衍生的DVG在蚊子细胞中的干扰活性完全丧失;仅DVGCA2、CA3和CM1在U4.4细胞中在10:1的摩尔比下将荧光素酶活性显著降低1至2log(图35E)。
基孔肯雅DVG可为广谱抑制剂。基孔肯雅病毒印度洋谱系属于东非、南非和中非(ECSA)基因型,并且与属于亚洲基因型的基孔肯雅病毒加勒比海毒株具有大约7%的核苷酸差异20。在先前的实验中,源自印度洋谱系或加勒比海毒株的DVG已针对表达Gaussia荧光素酶的加勒比海毒株病毒进行了测试。重要的是,所有CHIKV IOL衍生的DVG都抑制了加勒比海毒株,表明DVG可以在同一病毒种类中广泛发挥作用(图35B、C、D、E)。为了扩展这些结果,我们使用CHIKV IOL株作为目标病毒在293T中重复了相同的实验。在这种情况下,我们通过病毒滴度而不是发光来测定抑制作用。大多数DVG导致病毒滴度中度或显著地降低,无论它们是从哺乳动物(图36A)还是蚊子(图36B)环境中识别出来的。
我们接下来研究了CHIKV DVG是否可以更广泛地抑制甲病毒属。我们以阿良良病毒(O'nyong'nyong virus)(ONNV,CHIKV的最近亲)或Sindbis病毒(SINV,非常远缘的亲属)为靶点,在293T细胞中进行了相同的实验。虽然大多数DVG失去了抑制作用,但一些DVG仍显著抑制阿良良病毒(CV2和CH1)(图36C)。在蚊子衍生的DVG中,CM1保持抑制活性,几乎没有可检测到的阿良良病毒滴度(图36D)。当针对远缘相关的Sindbis病毒进行测试时,所有DVG的干扰活性都丧失了,但对抑制Sindbis病毒的CM1而言,干扰活性降低了2logs(图36E、F)。这些结果证实,源自一种甲病毒的一些DVG可以对不同的毒株具有抑制活性,包括来自同一属的密切相关的病毒,以及在某些情况下更远缘相关的病毒。
基孔肯雅DVG阻断病毒在埃及伊蚊中的体内传播。在证明DVG可用于限制/抑制体外感染后,我们测试了它们的干扰活动是否可用于阻断蚊子宿主中的感染或传播。为此,在给埃及伊蚊喂食含有CHIKV Carib-Gluc病毒的血餐前2天,我们将CV4、IH1或CM1 DVG、对照RNA或PBS的纯化RNA注入埃及伊蚊体内。感染后五天,处死蚊子并从尸体的其余部分解剖中肠(图37A)。通过量化荧光素酶活性来测量每只蚊子的病毒复制。无论是否存在干扰DVG候选,所有蚊子中肠中的复制都是相似的。然而,在CV4和CM1处理的蚊子尸体中复制显著降低(图37B)。然后,量化中肠(代表感染)和尸体(代表病毒传播)中的病毒,并根据是否检测到感染性病毒(每个器官的检测限30PFU)分类为阳性或阴性。所有组的阳性中肠比例相似(在81%和91.7%之间)(图37C),证实了每组在喂食血餐后感染的蚊子数量相似。另一方面,DVG的存在显著影响病毒传播:与注射PBS的蚊子相比,注射CV4、IH1或CM1 DVG的蚊子的传播率较低(各组为感染蚊子总数的16.7%、47.6%和41.7%)(图37C)。这些结果证实DVG可影响蚊子宿主中病毒的体内复制和传播。
图33:不同宿主中基孔肯雅病毒(CHIKV)缺陷病毒基因组(DVG)的体外生成。CHIKV的加勒比毒株(Carib)和印度洋谱系(IOL)在蚊子(U4.4,Aag2)或哺乳动物(Vero,Huh7)细胞中以高MOI传代,一式三份。对于每一代,从前一代采集的上清液用于感染新鲜细胞。所述感染持续48至72小时。(A)DVG通过传代积累。CHIKV Carib DVG在2个哺乳动物细胞系(Vero,Huh7)和2个蚊子细胞系(Aag2,U4.4)的每次复制中出现的总频率,在对每个样本进行RNA深度测序并使用Bbmap管道输出量化DVG后确定。分析中排除了覆盖率低于200的样本。DVG计数在每次传代(x轴)处以对数刻度(y轴)表示。(B)不同细胞类型中CHIKV Carib或IOL DVG的热图。对各代的病毒种群进行深度测序(RNAseq)并通过BBmap管道进行分析。对于每个不同的细胞类型(y轴),整个基因组中每个缺失核苷酸位置(x轴)的归一化频率的所有传代和复制的平均值显示为热图(橙色阴影)。(C)由CHIKV Carib通过高MOI传代产生的缺失的分析。为每种细胞类型绘制了生成的DVG断点的起始(x轴)和终止(y轴)位置。不同的簇称为A、B、C、D。
图34:蚊子中基孔肯雅DVG的体内生成。(A)向泰国埃及伊蚊喂食感染有106PFU/mlCHIKV Carib的血餐。7天后,处死10只蚊子,解剖中肠、腹壁(身体)、胸、头和腿/翅。通过滴定确认感染后,提取病毒RNA并进行深度测序。(B)分析CHIKV Carib在集中在一起的9只感染蚊子中产生的缺失。绘制了每个器官中所产生的DVG断点的起始(x轴)和终止(y轴)位置。(C)在2只蚊子的不同器官中产生DVG断点的起始(x轴)和终止(y轴)位置。红点代表2695起始至5358结束的缺失,该DVG称为CM1。它旁边的数字表示每百万读数的读数(RPM)。
图35:缺陷病毒基因组可干扰基孔肯雅病毒的复制。(A)DVG候选以及它们所在的细胞类型和毒株(C Carib,IOL)的示意图。(B-E)DVG活性的体外测量。从哺乳动物细胞传代(B、D)或蚊细胞传代(C、E)中识别的每种DVG候选与CHIKV Carib-荧光素酶以1:1或10:1摩尔比在293T细胞(B、C)或U4.4细胞(D、E)中共转染。48小时后,测量荧光素酶活性。(显示了三个独立实验中的一个实验的代表性结果,n=3,*p<0,05,**p<0,01,***p<0,001,****p<0,0001,在对单向ANOVA检验进行Dunnett多重比较后,与野生型相比,ns不显著。)
图36:缺陷病毒基因组在甲病毒家族中具有广谱抑制活性。测试在哺乳动物细胞传代中(A、C、F)或蚊细胞传代(B、D、F)中识别的DVG对CHIKV IOL(A、B)、阿良良病毒(ONNV)(C、D)和辛德比斯病毒(Sindbis virus,SINV)(E、F)的抑制作用。DVG候选与CHIKV IOL(A、B)、ONNV(C、D)和SINV(E、F)在293T细胞中以10:1的摩尔比共转染。48小时后,测量病毒滴度。(三个独立实验中的一个实验的代表性结果,n=3,*p<0,05,**p<0,01,***p<0,001,****p<0,0001,在对单向ANOVA检验进行Dunnett多重比较后,与野生型相比,ns不显著。)
图37:在埃及伊蚊中缺陷病毒基因组阻止基孔肯雅病毒的体内病毒传播。(A)在喂食含有106PFU/ml的感染血餐之前,将150ng DVG候选RNA(IH1、CV4或CM1)、对照RNA或PBS注射到埃及伊蚊体内。5天后,处死蚊子,将中肠从尸体中分离。(B)测量每只蚊子的中肠或尸体的萤光素酶活性。(C)病毒滴定后,确定阳性中肠或尸体的比例(例如PFU≥100PFU/ml)。(显示了两个独立实验中的一个实验的代表性结果,n=24,*p<0,05,**p<0,01,***p<0,001,在采用多重比较(B)进行单向ANOVA或卡方检验,采用Holm校正多重比较(C)后,与PBS相比,ns不显著)。
图38:基孔肯雅病毒DVG不会自我复制。293T细胞用DVG或CHIKV Carib体外转录的RNA转染,并在转染后8、20、28和44小时采集。提取细胞RNA并用于进行使用Taqman探针的RT-qPCR。
图39:通过病毒滴定测定DVG体外活性。将每种DVG候选(源自蚊子细胞)的体外转录RNA与CHIKV Carib-荧光素酶RNA以1:1或10:1的摩尔比在U4.4细胞中共转染。48小时后,对样本进行滴定并测定萤光素酶活性(图34E)。(n=3,**p<0,01,****p<0,0001,在对单向ANOVA检验进行Dunnett多重比较后,与野生型相比,ns不显著。)。
图41列出了研究的CHIKV DVG的特征。DVG,缺陷病毒基因组;CHIKV,基孔肯雅病毒;缺失位置,受缺失影响的基因组区域,可包括包膜蛋白(E)、非结构蛋白(NSP)或3’非翻译区(3’UTR)。
讨论
几乎在所有RNA病毒家族中都有描述6,21并且通常认为是病毒复制的废产物——缺陷干扰粒子以及更一般地讲的DVG——最近因其可能用作抗病毒工具而受到关注15,6,22-26。事实上,人类自然感染中DVG的存在与呼吸道合胞病毒和流感病毒临床研究中的轻型病症相关10,13;流感缺陷干扰粒子保护小鼠免受致命的攻击22,23,27。在这项研究中,我们旨在尽可能广泛地描述在哺乳动物和蚊子环境中在基孔肯雅病毒体外感染期间以及在蚊子宿主中体内感染期间出现的带有缺失的DVG。我们表明,基孔肯雅DVG出现在所有体外和体内的环境中,但它们的类型和丰度取决于宿主和细胞类型以及病毒株,强调了细胞环境和病毒基因组都具有DVG生成的决定因素。例如,簇D在两种伊蚊属蚊子细胞中都是强表达的,尽管缺失并不发生在完全相同的位置,但其在哺乳动物细胞中却非常罕见。
为了找到可用作抗病毒药物的DVG,我们选择了最冗余的DVG,它们在几种情况下出现并在传代中传播,我们认为这表明更高的适应度和被野生型病毒包装的能力。当相对于野生型病毒以更高的量使用时,大多数候选显示出有潜力的抑制能力。值得注意的是,由于较小的基因组应更快地复制7,8,传统的教条建议最小的DVG将最有效地劫持亲本病毒复制机制并胜过野生型病毒。然而,在我们的工作中,识别的最小DVG(来自簇B的两种DVG)没有或几乎没有干扰活性。这一观察表明,对复制酶和复制速度的严格竞争并不是DVG干扰亲本病毒的唯一机制,而且他们先前描述的免疫刺激活性7,9-11,28-33或对结构蛋白资源的竞争8,34也可发挥重要作用。重要的是,我们使用了Illumina深度测序技术,该技术仅生成小读数来识别DVG,使得几乎不可能识别具有多个缺失和/或主要重排的DVG。将来,将这种方法与长读测序技术(如纳米孔)相结合,可能会更全面地了解基孔肯雅病毒种群中生成的DVG的性质,并了解它们的作用方式。
在埃及伊蚊体内生成的DVG中,CM1引起了我们的注意,因为它可以体内跨越障碍(bottleneck)。在自然病毒感染期间,在感染性血餐之后,中肠是病毒到达血腔传播到所有其他器官之前首先被感染的器官35。几项关于蚊子的研究表明,病毒从中肠排出是蚊子感染过程中的主要族群障碍,种群规模急剧减少,其次是从唾液腺排出——其为病毒通过感染的唾液传播给哺乳动物宿主的必要步骤35–39。CM1是在两只独立蚊子的中肠中新生成的,并且发现传播到相同蚊子的体壁、头和腿/翅。CM1在其他器官中重新生成是不可能的,因为这种DVG从未出现在没有在中肠生成它的任何其他蚊子的任何器官中。尚不清楚CM1如何或为何能够跨越中肠障碍。一种可能性是它属于一个总的感染病毒单元——同时包含多个病毒基因组并将其转运到单个细胞的结构,例如多倍体病毒体、病毒体聚集体或含有病毒体的脂质囊泡40,41。已经提出了包含DVG的总的感染单元的可能性。实际上,Leeks等人模拟了如果病毒种群包含多个DVG,总的感染单元可变得非常大。尽管如此,与游离病毒体相比,干扰DVG的存在不利于在总的感染单元内的传播42。与亲本病毒相比,虽然CM1在高摩尔比下具有抑制活性,但其在蚊子样本中的频率非常低(每百万4至176读数)。
其中一些干扰DVG的一个有价值的特征是它们的广谱活性,不仅对其他基孔肯雅病毒株而且对其他甲病毒都具有抑制作用。这种交叉反应性已经在流感和仙台病毒中报告,因为它们的DVG在哺乳动物模型中显示是有效的疫苗或疫苗佐剂,不仅可对抗它们所源自的病毒,还可对抗不相关的病毒15,22–26。从治疗的角度来看,这是特别令人感兴趣的,因为关节炎甲病毒在世界范围内传播的风险是公认的3,43–47,特别是因为目前没有针对任何这些病毒的抗病毒药物或疫苗获得许可。在这种情况下,任何可跨病毒属或病毒科发挥作用的治疗(抗病毒药物或疫苗)都将有助于应对将到来的爆发。
将来,测试基孔肯雅DVG是否可在哺乳动物体内模型中发挥抗病毒作用将是重要的;但是,仍然需要开发适当的递送系统。在先前关于甲型流感和仙台DVG的研究中,作者通过在蔗糖梯度上对野生型病毒和DVG混合物进行超离心来分离DVG15,22–26。然而,我们无法使用这些方法成功地将基孔肯雅DVG与野生型病毒分离。新方法,例如在纳米颗粒或纳米结构脂质中递送RNA或DNA48,49,或尝试将DVG包装在病毒样颗粒(VLP)中。另一个需要克服的主要障碍是选择体内模型。可使用野生型C57BL/6,但由于小鼠仅出现短暂的轻度感染,因此即使是最佳的DVG候选也很难证明其抑制作用。而最常用的小鼠模型依赖于干扰素α/β敲除50,51,将排除先天免疫的诱导,这可能是基孔肯雅DVG的重要作用机制10,28–31,33。
最后,当在感染性血餐前两天在埃及伊蚊中注射时,三种DVG显著减少了病毒从蚊子中肠的传播,从而将蚊子的状态从有竞争力的基孔肯雅病毒传播媒介转变为没有竞争力的基孔肯雅病毒传播媒介。这一结果证明了DVG可能是控制媒介群体中基孔肯雅病毒感染的有用工具。由于在虫媒病毒爆发期间在野外释放没有竞争力的蚊子已证明是有效的流行病控制策略52,53,并且尽管需要更简单的递送系统,提出干扰DVG不仅可用作基孔肯雅病毒还可用作任何虫媒病毒的控制策略是诱人的。此外,干扰DVG可能是安全的抗病毒工具,因为它们是不能自我复制的惰性分子,并且仅在存在野生型病毒时才具有活性。
总之,这项工作描述了在脊椎动物和无脊椎动物环境中基孔肯雅病毒感染期间在媒介蚊体外和体内生成的不同类型的缺失DVG。此外,我们确定了在脊椎动物和无脊椎动物宿主体外能够抑制野生型基孔肯雅病毒的最佳缺陷干扰粒子候选的筛选标准。一个有趣的观察结果是一些能够与相关甲病毒相互作用的干扰DVG的广谱活性。最后,我们表明预先暴露于DVG可调节蚊子体内的病毒传播。这些结果强调了这样一种观点,即缺陷干扰粒子可能是基孔肯雅病毒感染的有用治疗工具以及有效的媒介控制策略(vector controlstrategy)。
CHIKV DVG序列选自由以下组成的组:SEQ ID NO:34(CHIKV DVG-IV1)、SEQ IDNO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKV DVG-IV4)、SEQ ID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKVDVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQ ID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:45(CHIKV DVG-CH2)、SEQID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)和SEQ ID NO:53(CHIKV DVG-CA4)。
优选的CHIKV DVG序列选自由以下组成的组:SEQ ID NO:34(CHIKV DVG-IV1)、SEQID NO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKV DVG-IV4)、SEQ ID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKV DVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)和SEQID NO:53(CHIKV DVG-CA4)。
最优选的CHIKV DVG序列选自由以下组成的组:SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:38(CHIKVDVG-IH1)和SEQ ID NO:43(CHIKV DVG-CV4)。
实施例5:鼻病毒(RV)
鼻病毒中出现的DVG的生成和表征
方法:用于识别缺陷病毒基因组(DVG)的鼻病毒(RV)类型包括RV-A01a(NC_038311.1)、RV-A16(L24917.1)、RV-B14(L05355.1)和RV-C15(GU219984.1)。简而言之,12孔板在完全培养基(DMEM、10% FBS、1%青霉素/链霉素)中接种3.5x105(350,000)个H1-HeLa细胞/孔,并在37℃/5%CO2下培养过夜以达到约90%的融合度。对于RV-C15病毒,使用HeLa-E8细胞系。第二天,该细胞以高(20)和低(0.1)感染复数(MOI)感染野生型RV-A01a、RV-A16、RV-B14和RV-C15病毒。在34℃/5% CO2下培养一小时后,去除病毒并用磷酸盐缓冲盐水(PBS)溶液洗涤细胞。然后,吸出PBS并加入1mL感染培养基(DMEM、2% FBS、1%青霉素/链霉素)。细胞在34℃/5% CO2下培养,直到观察到完全的致细胞病变效应(CPE)。在CPE后,通过三次重复的冻融循环采集病毒,并通过离心(17,000x g,4℃下10分钟)去除细胞碎片。将病毒上清液等分并储存在-80℃下备用。所述上清液用于将病毒传代到新鲜细胞中。重复该过程直至第10代(图42)。在病毒RNA分离之前,将100μL病毒上清液用5μL RNase A/T1(Thermo Scientific)处理,并将混合物在37℃下培养1小时。RNase处理后,每100μL病毒上清液加入300μL TRI试剂(Sigma)并混合均匀。然后,使用Direct-zol-96RNA试剂盒(ZymoResearch)分离RNA。依照制造商的方案进行柱内DNase处理。5微升分离的RNA(通常≤1ng/μL)用于文库制备。使用Illumina(新英格兰生物实验室(New England Biolabs))的NEBNextUltra II RNA文库制备试剂盒制备文库。在文库过程中使用复用寡核苷酸(Illumina)。使用高灵敏度DNA芯片在Bioanalyser 2100(Agilent)上检查文库制备的质量。在NextSeq500测序仪(Illumina)上使用NextSeq 500Mid Output kit v2.5(Illumina)(151次循环)对稀释至1nM的文库进行测序。通过内部管道分析所获得的序列以识别DVG。
考虑到存在众多RV类型,我们对RV-A01a、RV-A16、RV-B14和RV-C15进行了实验,以确保所有RV物种都表示在我们的数据集中。如上所述,这些病毒在H1-HeLa细胞系中以低和高MOI传代最多达10次(图42)。样本的深度测序和生物信息学分析确定了族群中RV基因组的所有缺失热点。对于所有测试的RV类型,主要缺失热点都包含在基因组的P1区域(结构蛋白)内,并且它们都在框内(图43-46)。此外,所有样本在RNA分离和深度测序之前都经过RNase处理,这表明识别的DVG可包装到病毒衣壳中。由于其与主要热点内的DVG相关,在所有情况下,顺式作用复制元件(cis-acting replication element,cre)都被保留,使它们与其他DVG相比具有复制优势。
TIP候选的选择基于热点的存在、沿基因组的位置、缺失的大小以及每个缺失在传代内/跨传代的出现频率。TIP候选的名称包括RV类型,后跟TIP编号(例如B14-TIP-01)(图47和图48)。
图42.用于生成鼻病毒缺陷病毒基因组的方法。整个过程包括以低/高MOI进行盲传代,然后进行病毒RNA纯化、深度测序和数据分析,以识别缺陷病毒基因组(DVG)。传代前,12孔板在完全培养基(DMEM、10% FBS、1%青霉素/链霉素)中接种3.5x105个H1-HeLa细胞/孔,然后在37℃/5% CO2下培养24小时。对于RV-A01a、RV-A16和RV-B14,使用H1-HeLa细胞;对于RV-C15,使用HeLa-E8细胞。实验当天,细胞(约90%融合度)以0.1(低-MOI)和20(高-MOI)的MOI进行感染。感染的细胞在34℃/5% CO2下培养一小时。培养后,去除病毒,用1xPBS洗涤细胞,然后加入新鲜感染培养基(DMEM、2% FBS、1%青霉素/链霉素)。细胞在34℃/5% CO2下培养直到观察到完全的致细胞病变效应(CPE)。在CPE后,通过三次重复的冻融循环采集病毒,并通过离心(17,000x g,4℃下10分钟)去除细胞碎片。上清液用于将病毒传代到新鲜的H1-HeLa细胞中。重复该过程,直至第10代。
图43.在H1-HeLa细胞中以高滴度传代RV-A01a。(A)主要缺失簇在P1(结构)编码区内形成,并且该簇内的缺陷病毒基因组(DVG)均在框内。该图表示已识别缺失的起始与终止位置。根据缺失的大小,数据分为框内(左;红色圆圈)和框外(右;青色圆圈)缺失。来自所有传代(P01-P10)和所有复制(n=5)的汇总数据。(B)缺失的出现随传代数(P01-P10)而变化的函数。每个图代表来自所有复制(n=5)的汇总数据。顶行图代表框内缺失,而底行图代表整个基因组的框外缺失。
图44.在H1-HeLa细胞中以高滴度传代RV-A16。(A)主要缺失簇在P1(结构)编码区内形成,并且该簇内的缺陷病毒基因组(DVG)均在框内。该图表示已识别缺失的起始与终止位置。根据缺失的大小,数据分为框内(左;红色圆圈)和框外(右;青色圆圈)缺失。来自所有传代(P01-P09)和所有复制(n=5)的汇总数据。(B)缺失的出现随传代数(P01-P09)而变化。每个图代表来自所有复制(n=5)的汇总数据。顶行图代表框内缺失,而底行图代表整个基因组的框外缺失。
图45.在H1-HeLa细胞中以高滴度传代RV-B14。(A)主要缺失簇在P1(结构)编码区内形成,并且该簇内的缺陷病毒基因组(DVG)均在框内。该图表示已识别缺失的起始与终止位置。根据缺失的大小,数据分为框内(左;红色圆圈)和框外(右;青色圆圈)缺失。来自所有传代(P01-P10)和所有复制(n=6)的汇总数据。(B)缺失的出现随传代数(P01-P10)而变化。每个图代表来自所有复制(n=6)的汇总数据。顶行图代表框内缺失,而底行图代表整个基因组的框外缺失。
图46.在HeLa-E8细胞中以高滴度传代RV-C15。(A)P1(结构)编码区内的主要缺失簇形式和该簇内的缺陷病毒基因组(DVG)均在框内。该图表示已识别缺失的起始与终止位置。根据缺失的大小,数据分为框内(左;红色圆圈)和框外(右;青色圆圈)缺失。来自所有传代(P01-P10)和所有复制(n=5)的汇总数据。(B)缺失的出现随传代数(P01-P10)而变化。每个图代表来自所有复制(n=5)的汇总数据。顶行图代表框内缺失,而底行图代表整个基因组的框外缺失。
图47.鼻病毒TIP候选。(A)鼻病毒(RV)-B14、(B)RV-A01a、(C)RV-A16和(D)RV-C15TIP候选。TIP候选的名称包括RV类型,后跟TIP编号(例如B14-TIP-01)。缺失用水平红线表示,而突变用垂直红线表示。在每个图的顶部,显示了每种病毒类型的野生型基因组(深灰色),并标明了病毒蛋白的位置。结构蛋白与它们出现的顺序相同:VP4、VP2、VP3和VP1。非结构蛋白与它们出现的顺序相同:2A、2B、2C、3A、3B、3C和3D。x轴代表以核苷酸(nts)为单位的病毒基因组长度。
图48.鼻病毒TIP候选的详细信息。每个TIP候选报告的特征包括:其ID、缺失的起始和终止位置、缺失的长度(缺失长度=终止-起始)、突变(如有)以及缺失在框内或框外是否保持开放阅读框(ORF)。如果缺失可被3整除(余数=0),则其在框内,否则在框外。起始和终止位置分别表示最后剩余的和最后缺失的。
鼻病毒TIP候选体外抑制野生型病毒
方法:转染前,96孔板在完全培养基(DMEM、10% FBS、1%青霉素/链霉素)中接种2.0x104个H1-HeLa细胞/孔,然后在37℃/5% CO2下培养24小时以达到约90%的融合度。用感染培养基(DMEM、2% FBS、1%青霉素/链霉素)替换完全培养基,并使用TransIT-mRNA转染试剂以指定的摩尔比将所述细胞使用野生型和选定的TIP候选进行共转染。所有共转染均以1:1、1:5和1:10(WT:TIP)的摩尔比进行,一式三份(n=3)。在仅WT RNA的情况下,“1”的量等于25ng RNA。转染的细胞在34℃/5% CO2下培养48小时。培养后,通过三次重复的冻融循环采集病毒,并通过离心(17,000xg,4℃下10分钟)去除细胞碎片。感染性病毒的滴度通过空斑测定法进行测定。作为对照,WT RNA与对照RNA(pTRI-Xef:爪蟾延长因子1α)共转染,这导致与仅WT相似的滴度。还测试了其他对照,包括单独的对照RNA、单独的TIP候选和模拟转染,未产生感染性病毒,正如预期的。使用来自RV-A01a和RV-A16的WT RNA,以相同的方式测试了表现最佳的TIP候选的泛鼻病毒活性。
结果表明,从这组精选的TIP候选中,B14-TIP-03候选通过将WT滴度降低近100倍而表现最佳(图49A)。作为安全特征,我们生成了B14-TIP-03的非复制变体(K13L),并将其重命名为“B14-TIP-06”。B14-TIP-06具有与B14-TIP-03类似的抗病毒活性(图49B)。正如预期的,在WT RNA的背景下引入相同的突变不会生成活病毒(图49B)。这些结果对使用DVG作为潜在TIP的安全性具有重要意义。
我们的体外结果表明B14-TIP-03的抗病毒特征是泛鼻病毒。将B14-TIP-03与RV-A01a和RV-A16共转染可显著降低感染性病毒滴度。进一步增强B14-TIP-03用作针对多种RV类型的广谱抗病毒药物的潜力。
图49.泛鼻病毒TIP候选降低体外野生型滴度。(A)将RV-B14-WT和TIP候选RNA共转染到H1-HeLa细胞中,以评估一组精选的TIP候选(B14-TIP-01、B14-TIP-03和B14-TIP-10)的功效。所有共转染均以1:1、1:5和1:10(WT:TIP)摩尔比进行。在仅B14-WT的情况下,“1”的量等于25ng RNA。作为对照,RV-B14-WT RNA单独转染或与对照RNA(pTRI-Xef:爪蟾延长因子1α)共转染。还测试了其他对照,包括单独的对照RNA、单独的TIP候选和模拟转染,没有产生感染性病毒,正如预期的。(B)B14-TIP-03的非复制变体(K13L变体-在3C蛋白内)TIP被构建并重命名为“B14-TIP-06”。B14-TIP-06TIP候选具有与B14-TIP-03TIP候选相似的抗病毒活性。正如预期的,在WT基因组的背景下引入相同的突变是不能存活的。(C)通过将候选TIP与RV-B14、RV-A01a和RV-A16野生型基因组共转染来测试B14-TIP-03的泛鼻病毒活性。x轴代表测试的WT:TIP样本以及它们在括号中的摩尔比,y轴代表Log10(PFU/mL)。每个条件至少一式三份进行测试(n≥3)。
鼻病毒TIP候选是体外抗病毒先天免疫的有效刺激物
方法:转染前,96孔板在完全培养基(DMEM、10% FBS、1%青霉素/链霉素)中接种2.0x104个H1-HeLa细胞/孔,然后在37℃/5% CO2下培养24小时以达到约90%的融合度。用感染培养基(DMEM、2% FBS、1%青霉素/链霉素)替换完全培养基,并且使用TransIT-mRNA转染试剂,使用WT和B14-TIP-03以1:10(WT:TIP)的摩尔比共转染细胞。“1”的量等于25ngWT RNA。所有共转染一式三份(n=3)。转染的细胞在34℃/5% CO2下培养3小时,然后用磷酸盐缓冲盐溶液洗涤三次,以去除输入RNA并防止其干扰RT-qPCR实验。然后,将转染的细胞在34℃/5% CO2下培养48小时。培养后,通过三次重复的冻融循环采集病毒,并通过离心(17,000xg,4℃下10分钟)去除细胞碎片。为了分离病毒RNA,依照制造商推荐的方案使用Direct-zol RNA Miniprep试剂盒(Zymo Research)。然后,依照制造商推荐的方案,使用SuperScript IV(ThermoFisher)逆转录酶和随机六聚体引物对总RNA进行逆转录。然后,使用针对视黄酸诱导基因I(RIG-I)、黑色素瘤分化相关基因5(MDA5)、干扰素(IFN)-α1、IFN-β1和IFN-λ1基因的基因特异性引物,使用Power SYBRTM Green PCR Master Mix对2uL的10倍稀释的cDNA进行扩增。用3-磷酸甘油醛脱氢酶(GAPDH)管家基因作为对照,使用针对模拟转染细胞的ΔΔCt分析进行相对倍数变化计算。
结果:基于qPCR结果,B14-TIP-03是一种有效的抗病毒先天免疫刺激剂。RV-B14-WT和对照RNA(pTRI-Xef:爪蟾延长因子1α)的共转染致使所有测试基因的轻度诱导。另一方面,RV-B14-WT和B14-TIP-03RNA的共转染致使模式识别受体(PRR)(例如RIG-I和MDA5)的基因表达显著增加。此外,B14-TIP-03还诱导了IFN-β1和IFN-λ1的基因表达,但不诱导IFN-α1的基因表达。这些结果表明了B14-TIP-03的主要作用机制。
图50.TIP候选B14-TIP-03是一种有效的抗病毒先天免疫刺激剂。倍数变化值显示在每个柱形图的上方。所有共转染均以1:10(WT:TIP)的摩尔比进行。在仅B14-WT的情况下,“1”的量等于25ng RNA。作为对照,RV-B14-WT RNA用对照RNA(pTRI-Xef:爪蟾延长因子1α)转染。x轴代表测试的WT:TIP样本,y轴代表Log10(PFU/mL)。每个条件至少一式两份进行测试。
已识别的DVG在图51和52中列出。
RV DVG序列选自由以下组成的组:SEQ ID NO:55(RV DVG A01a-TIP-01)、SEQ IDNO:56(RV DVG A01a-TIP-02)、SEQ ID NO:57(RV DVG A01a-TIP-03)、SEQ ID NO:58(RVDVG A01a-TIP-04)、SEQ ID NO:59(RV DVG A01a-TIP-05)、SEQ ID NO:60(RV DVG A01a-TIP-06)、SEQ ID NO:62(RV DVG A16-TIP-01)、SEQ ID NO:63(RV DVG A16-TIP-02)、SEQID NO:64(RV DVG A16-TIP-03)、SEQ ID NO:65(RV DVG A16-TIP-04)、SEQ ID NO:66(RVDVG A16-TIP-05)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ ID NO:91(RV DVG C15-TIP-03)、SEQ ID NO:68(RV DVG B14-TIP-01)、SEQ IDNO:69(RV DVG B14-TIP-02)、SEQ ID NO:70(RV DVG B14-TIP-03)、SEQ ID NO:71(RV DVGB14-TIP-04)、SEQ ID NO:72(RV DVG B14-TIP-05)、SEQ ID NO:73(RV DVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ ID NO:75(RV DVG B14-TIP-08)、SEQ ID NO:76(RV DVG B14-TIP-09)、SEQ ID NO:77(RV DVG B14-TIP-10)、SEQ ID NO:78(RV DVG B14-TIP-11)、SEQ ID NO:79(RV DVG B14-TIP-12)、SEQ ID NO:80(RV DVG B14-TIP-13)、SEQID NO:81(RV DVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ ID NO:83(RVDVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ ID NO:85(RV DVG B14-TIP-18)、SEQ ID NO:86(RV DVG B14-TIP-19)和SEQ ID NO:87(RV DVG B14-TIP-20)。
优选的RV DVG序列选自由以下组成的组:SEQ ID NO:55(RV DVG A01a-TIP-01)、SEQ ID NO:62(RV DVG A16-TIP-01)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:68(RV DVG B14-TIP-01)、SEQ ID NO:70(RV DVG B14-TIP-03)、SEQ ID NO:73(RV DVG B14-TIP-06)和SEQ ID NO:77(RV DVG B14-TIP-10)。
最优选的RV DVG序列选自由以下组成的组:SEQ ID NO:70(RV DVG B14-TIP-03)和SEQ ID NO:73(RV DVG B14-TIP-06)。
实施例6:黄热病病毒(YFV)
黄热病病毒传代过程中DVG的生成和表征
黄热病病毒Asibi(YF-Asibi)毒株和疫苗(YF-17D)毒株在哺乳动物(SW13,Vero)和蚊子(C6/36)细胞系中以高和低MOI进行的12次生物复制中盲传代10至20次。图53表示通过焦点形成测定法对所有进行传代的样本的滴定。该图显示了病毒滴度(以ffu/ml为单位,以对数刻度表示)和每次传代的MOI值。从每个实验中选择4代进行测序,选择作为病毒滴度下降之前的传代。目前,SW13中YF-Asibi和YF-17D的高、低MOI感染样本已经深度测序,而其他样本已准备好进行文库制备。
对已测序传代的计算分析确定了整个基因组中的所有缺失热点和种群中出现的全部DVG。图54是在SW13细胞中YF-17D和YF-Asibi以高和低MOI的传代进行测序产生的缺失热图。每个图代表一个不同的MOI,而每一行是一次不同的传代。此处显示的数据将所有生物复制组合在一起。核苷酸位置在x轴上表示并跨越整个基因组。分析表明,缺失热点在传代过程中是常见的并且被保留,这表明这些DVG具有更高的适应度,并且可被包装以感染新细胞。对这些数据的分析揭示了高MOI和低MOI共有的缺失热点。此外,一些缺失热点是两种病毒株共有的。图55示出了在两种YF毒株中发现的DVG的进一步比较。该图突出显示了两种病毒株中的一簇缺失,该簇缺失随着传代系列的进展而出现并且被保留(表明这些DVG的高适应度)。
图XX4中示意性表示的最保留的DVG已被选择用于TIP的重新合成。
图53:盲传代的滴定。每个图显示了YF-17D和YF-Asibi在不同细胞系上的连续盲传代期间收集的样本。使用焦点形成测定法(FFA)对样本进行滴定,在此表示为各代的12次复制的平均值,以每毫升的焦点形成单位(ffu/ml)表示。各代计算感染的MOI显示为12次复制的平均值(红色条)。
图54:SW13细胞中的DVG识别。对来自选定传代的YF-Asibi和YF-17D群体进行深度测序(RNAseq),并且整个YF基因组中每个缺失的核苷酸位置(x轴)的归一化频率显示为热图。每个图中的每一行代表不同的传代。每个图代表所使用的两个YF毒株的高和低MOI复制的不同传代数。
图55:SW13细胞中YF DVG热点的识别。绘制了使用YF-17D(A)和YF-Asibi(B)的SW13细胞传代的缺失起始(x轴)和终止(y轴)位置。对于所分析的每次传代,都显示了框内(橙色)和框外(青色)缺失。对于两种病毒株,在起始和终止位置为约500-3000nt起始-终止的区域中观察到明显的热点。
图56:候选YF DVG的示意图。YFV候选DVG的选择是基于它们在整个传代过程中的保留和频率。每个DVG的来源显示在左侧。左边的每个字母代表DVG的临时名称。
YFV DVG序列选自由以下组成的组:SEQ ID NO:93(YFV DVG-A)、SEQ ID NO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQ ID NO:96(YFV DVG-D)、SEQ ID NO:97(YFVDVG-E)、SEQ ID NO:98(YFV DVG-F)、SEQ ID NO:99(YFV DVG-G)、SEQ ID NO:100(YFV DVG-H)、SEQ ID NO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFV DVG-K)和SEQ ID NO:104(YFV DVG-L)。
实施例7:西尼罗河病毒(WNV)
西尼罗河病毒以色列1998毒株(West Nile virus Israel 1998strain)(WNV)在BHK或C6/36细胞中以高感染复数传代。简而言之,用0.1或10PFU/细胞的初始MOI感染接种以达到70-80%融合度的细胞。感染两天后,3μl或300μl被感染的细胞上清液(分别)用于后续传代的感染。所述传代重复10次。图57表示在BHK21细胞(图57A和B)和C6/36(图57C和D)中进行的所有传代的样本的滴定(通过焦点形成测定法)以及RNA定量(通过RT-QPCR)。从样本中提取的RNA也用于新一代测序。将使用RNA文库制备试剂盒(Illumina)制备的文库加载到Illumina NextSeq500测序仪上,使用150次循环单端读数。使用上述计算管道分析所获得的读数。对已测序传代的计算分析确定了整个基因组中的所有缺失热点和种群中出现的全部DVG。对来自BHK21或C6/36细胞10次传代后至少5个样本中的具有至少10个缺失的nt的至少2次读取的数据分析显示,缺失热点分散在两种细胞系的整个基因组中,但在BHK21细胞中更多(图58)。图59显示了在BHK21(图59A和B)和C6/36(图59C和D)中WNV以低和高MOI的传代进行测序产生的缺失热图。每个图中的每一行代表不同的传代数。分析表明,在蚊子细胞(C6/36)的传代过程中,缺失热点很常见并且被保留,这表明这些DVG具有更高的适应度,并且可被包装以感染新细胞,而对于哺乳动物细胞(BHK21),识别了更少的缺失热点。某些缺失热点是C6/36细胞系独有的,并且在频率方面会取代其他缺失,例如位于E糖蛋白内和周围的缺失热点(图59C和D)。该簇缺失在低MOI(图59C,第4代)和高MOI(图59D,第5代)中较早出现,并在下一代对于两个MOI均保留。然而,由于第5代后C6/36细胞中两个MOI的RNA下降(参见图57D),第6代后无法生成缺失热图。C6/36细胞第4、5和6代(高MOI)和第3、4和5代(低MOI)的热点缺失通过绘制缺失的起始和终止位置来识别(图60)。正如热图已经预测的(参见图59),在这样的区域中观察到明显的热点:对于两个MOI,起始和终止位置为约500-3000nt起始-终止的区域,对于低MOI,在第3代,对于高MOI,在第4代,但对于两个MOI仅框内(图60,比较橙色和蓝色点)。
总而言之,该数据显示了使用多个细胞系或宿主来确定DVG在不同条件下的总宽度和整体适应度的重要性。这些数据强调了细胞类型之间也存在许多差异,但揭示了随着传代系列的进展出现的一簇缺失(表明这些DVG的高适应度)。
从这些和其他分析中,我们选择了一系列DVG候选。候选者命名为编号1至6,如图61所示。候选者跨越各种大小,并且缺失发生在基因组中的不同位置——框内和框外,代表了比使用传统传代和分离所能识别的更广泛的DVG候选。
图57:样本生成-连续传代。每个图显示在不同细胞系上连续传代WNV期间收集的样本。使用焦点形成测定法(FFA)对样本进行滴定,并在此表示为每次传代(x轴)的3次复制的平均值(和标准差),以每毫升的焦点形成单位(ffu/ml;y轴)表示。BHK21(图A)和C6/36细胞(图C)的感染复数(MOI)为0.1(浅绿色)或10(深绿色)。在用总RNA分离核蛋白试剂盒从澄清的上清液中提取RNA后进行RNA定量。其表示为每次传代(x轴)的3次复制的平均值,以每毫升的病毒RNA拷贝数(病毒RNA拷贝/毫升;y轴)表示,并且BHK21(图C)和C6/36细胞(图D)的MOI为0.1(浅绿色)或10(深绿色)。
图58:10次传代后WNV基因组的缺失。BHK21或C6/36细胞10次传代后至少5个样本中的具有至少10个缺失的核苷酸的至少2次读取的数据分析。示出了缺失的数量和位置。
图59:在BHK21或C6/36细胞中传代的WNV的缺失热图。对来自BHK21(图A和B)或C6/36(图C和D)细胞中10次传代的WNV种群进行深度测序(RNAseq),并且整个基因组中每个缺失的核苷酸位置(x轴)的归一化频率(y轴)显示为热图。每个图中的每一行代表不同的传代。示出了每种细胞类型以高MOI和低MOI的传代。
图60:C6/36细胞中热点缺失的识别。绘制了具有WNV的C6/36细胞传代的缺失的起始(x轴)和终止(y轴)位置。示出了第4、5和6代(高MOI)和第3、4和5代(低MOI)的框内(橙色)和框外(青色)缺失。在这样的区域中观察到明显的热点:对于两个MOI,起始和终止位置为约500-3000nt起始-终止。
图61:候选WNV DVG的示意图。WNV候选DVG的选择是基于它们在C6/36细胞中的传代过程中的保留和频率。WT基因组显示在顶部,编码蛋白C(紫色)、prM(蓝色)、E(青色)、NS1(深绿色)、NS2A(浅绿色)、NS2B(黄色)、NS3(橙色)、NS4A(棕色)、NS4B(粉红色)和NS5(红色),以及5’和3’UTR(黑线),并标明了核苷酸编号。候选DVG从1到6编号,并且对于每个DVG,对应缺失的位置显示在右侧。UTR:未翻译区;ORF:开放阅读框。
WNV DVG序列选自由以下组成的组:SEQ ID NO:105(WNV DVG-1)、SEQ ID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ ID NO:109(WNV DVG-5)和SEQ ID NO:110(WNV DVG-6)。
实施例7:冠状病毒(CV)-作为针对SARS-CoV-2的潜在抗病毒抑制剂的DVG的识别
冠状病毒SARS-CoV-2株(BetaCoV/France/IDF0372/2020)在Vero E6细胞中以高感染复数传代。简而言之,细胞以5x105PFU/细胞的初始MOI感染。感染后3天,感染的细胞上清液用于后续传代中的感染。所述传代重复10次。整个过程包括以高MOI传代,然后是病毒RNA纯化、深度测序和数据分析,以识别缺陷病毒基因组(DVG)。
图62:SARS-CoV-2 DVG的深度测序图。根据丰度、传代后在细胞培养物中的保持和大小选择了3种DVG。这3种DVG被分离和测序。SARS-CoV-2 DVG 1、2和3的核苷酸序列为SEQID NO:111、SEQ ID NO:112和SEQ ID NO:113。选择其中之一SARS-CoV-2 DVG(具有SEQ IDNO/112核苷酸序列的SARS-CoV-2 DVG_2)进行进一步分析。
图63:在Vero E6细胞和A549-Ace2细胞(智人,上皮细胞、肺癌)(Homo sapiens,epithelial,lung carcinoma)中的竞争测定。将SARS-CoV-2 DVG_2在T7启动子控制下克隆到载体中。对应SARS-CoV-2 DVG_2克隆的RNA按照mMESSAGE mMACHINE T7转录试剂盒(Thermofisher)指示的程序合成。在用野生型SARS-CoV-2病毒感染细胞之前或之后4小时,将SARS-CoV-2 DVG_2克隆的RNA转染到Vero E6细胞或A549-Ace2细胞中。作为对照,在相同条件下转染与SARS-CoV-2 DVG_2克隆的RNA大小相同的小RNA。通过空斑测定法获得结果。如图63所示,与未处理的细胞相比,在Vero E6细胞和A549-Ace2细胞中(参见图63每个图表的左侧的两列),RNA对照的转染不会影响SARS-CoV-2的复制能力。SARS-CoV-2 DVG_2克隆的RNA的转染对SARS-CoV-2病毒在Vero E6细胞中的复制没有影响。在A549-Ace2细胞上,SARS-CoV-2病毒的复制能力受到SARS-CoV-2 DVG_2克隆的RNA的转染的影响,特别是当细胞内转染100ng RNA时。通过用10ng SARS-CoV-2 DVG_2克隆的RNA后处理A549-Ace2细胞,观察到SARS-CoV-2滴度降低2.5log。通过用100ng SARS-CoV-2 DVG_2克隆的RNA预处理或后处理A549-Ace2细胞,观察到SARS-CoV-2滴度降低2.5log。
SARS-CoV-2序列选自由以下组成的组:SEQ ID NO:111(SARS-CoV-2 DVG_1)、SEQID NO:112(SARS-CoV-2 DVG_2)和SEQ ID NO:113(SARS-CoV-2 DVG_3)。
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48.Pilot,R.等人,表面增强拉曼散射综述,《生物传感器》9,57(2019年)(AReview on Surface-Enhanced Raman Scattering.Biosensors 9,57(2019))。
49.Erasmus,J.H.等人,用于递送复制病毒RNA的纳米结构脂质载体可提供针对寨卡病毒的单一、低剂量保护,《分子治疗》(2018年)doi:10.1016/j.ymthe.2018.07.010(ANanostructured Lipid Carrier for Delivery of a Replicating Viral RNA ProvidesSingle,Low-Dose Protection against Zika.Mol.Ther.(2018)doi:10.1016/j.ymthe.2018.07.010)。
50.Couderc,T.等人,基孔肯雅病毒感染的预防和治疗,《传染病杂志》200,516–523(2009年)(Prophylaxis and therapy for Chikungunya virusinfection.J.Infect.Dis.200,516–523(2009))。
51.Haese,N.N.等人,基孔肯雅病毒感染和疾病的动物模型,《传染病杂志》214,S482–S487(2016年)(Animal Models of Chikungunya Virus Infection andDisease.J.Infect.Dis.214,S482–S487(2016))。
52.Ferguson,N.M.等人,模拟沃尔巴克氏体介导的阻断埃及伊蚊登革热病毒感染对病毒传播的影响,《科学转化医学》7,279ra37(2015年)(Modeling the impact on virustransmission of Wolbachia-mediated blocking of dengue virus infection ofAedes aegypti.Sci.Transl.Med.7,279ra37(2015))。
53.Ferguson,N.M.,控制蚊媒感染的挑战和机遇,《自然》559,490–497(2018年)(Challenges and opportunities in controlling mosquito-borne infections.Nature559,490–497(2018))。
SEQUENCE LISTING
<110> 巴斯德研究所
<120> 缺陷干扰病毒基因组
<130> B14451WO - HLQ/AD
<140> PCT/FR
<141> 2021-03-26
<150> US 63/000,998
<151> 2020-03-27
<160> 113
<170> PatentIn version 3.5
<210> 1
<211> 7334
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 1
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcatgggg 300
cgctctaata cggacatggt gtgaagagtc tactgagcta gttagtagtc ctccggcccc 360
tgaatgcggc taatcccaac tgcggagcac acgcccacaa gccagcgggt agtgtgtcgt 420
aacgggtaac tctgcagcgg aaccgactac tttgggtgtc cgtgtttcct tttatcttta 480
tattggctgc ttatggtgac aattaaagaa ttgttaccat atagctattg gattggccat 540
ccggtgtgca acagagcaat tatttaccaa tttgttggtt ttgtaccatt aaccttgaat 600
tctgtgacca cccttaatta tattttgacc cttaacgcag ctaaacatgg gttcgcaagt 660
gtctacacag cgctccggtt ctcatgaaaa ctcaaactca gccactgagg gttctaccat 720
aaactacacc accatcaatt actacaaaga ctcttatgct gccacagcag gcaaacagag 780
tctcaagcag gatccagaca agtttgcaaa tcctgttaaa gacatcttca ctgaaatggc 840
agcgccattg aagtccccat ccgctgaggc atgtggatac agtgatcgag tggcacaatt 900
aactattggc aactccacca tcaccacgca agaagcggct aacatcatag tcggttatgg 960
tgagtggcct tcttactgct cagattctga cgctacagca gtggataaac caacgcgccc 1020
ggatgtttca gtgaataggt tttacacgtt agacactaaa ttatgggaga aatcgtccaa 1080
gggatggtac tggaagttcc cggatgtgtt aactgaaact ggggtttttg ggcaaaatgc 1140
acaattccac tacctctacc gatcagggtt ctgcatccac gtgcagtgta atgctagtaa 1200
attccaccaa ggagcactcc tagtcgctgt cctaccagag tatgtcattg ggacagtagc 1260
aggcggcaca gggacggaag atacccaccc cccttataag cagacccaac ccggtgccga 1320
tggcttcgag ctgcagcacc cgtacgtgct tgacgctggc atcccaatat cacagttaac 1380
agtgtgccca caccagtgga ttaatttgag gaccaacaat tgtgctacaa taatagtgcc 1440
atacattaac gcactgcctt ttgattctgc cttgaaccat tgcaactttg gcctgctagt 1500
tgtgcctatt agtccactag actacgacca aggagcgacg ccagtaatcc ctataactat 1560
cacattggcc ccaatgtgtt ctgagttcgc aggtcttagg caggcagtca cgcaagggtt 1620
ccctaccgag ctaaaacctg gcacaaatca attcttaacc accgatgatg gtgtctcagc 1680
acctattcta ccaaacttcc accccacccc gtgtatccac atacctggtg aagtgaggaa 1740
tttgctagag ttatgccagg tggaaaccat tctggaggtt aataatgtgc ccacgaatgc 1800
cactagcttg atggagagac tgcgcttccc ggtctcagca caagcaggga aaggtgaact 1860
gtgtgcggtg tttagagccg atcctgggcg aaacggacca tggcaatcca ccttactggg 1920
tcagttgtgc gggtactaca cccaatggtc aggatcattg gaggtcacct tcatgtttac 1980
tggatccttc atggctaccg gcaagatgct catagcctat acaccgccag gaggtcctct 2040
gcccaaggac cgggcgaccg ccatgttggg cacgcacgtc atctgggatt ttgggctgca 2100
atcgtctgtt acccttgtaa taccatggat cagcaacact cattatagag cacatgcccg 2160
agatggagtg tttgactact acaccacagg gttggtcagt atatggtatc agacaaatta 2220
cgtggttcca attggtgcgc ccaacacagc ctatataata gcactagcgg cagcccaaaa 2280
gaacttcact atgaaattgt gcaaggatgc tagtgatatc ttgcagacgg gcaccatcca 2340
gggagatagg gtggcagatg taattgaaag ctccatagga gatagcgtga gcagagccct 2400
cactcacgct ctaccagcac ccacaggtca gaacacacag gtgagcagtc atcgactgga 2460
tacgggcaag gttccagcac tccaagctgc tgaaattgga gcatcatcaa atgctagtga 2520
cgagagtatg attgagacac gctgtgtcct caactcgcac agtacagcag agaccactct 2580
tgatagtttc ttcagcaggg cgggattagt tggagagata gatctccctc ttgagggcac 2640
aactaaccca aatggttatg ccaactggga catagatata acaggttacg cgcaaatgcg 2700
tagaaaggta gagctcttca cctacatgcg ctttgatgca gagttcactt ttgttgcgtg 2760
tacacctacc ggggaagttg ttccacaact gctccaatat atgtttgtgc cacctggagc 2820
cccaaagcca gattctaggg aatcccttgc atggcaaacc gccactaacc cctcagtttt 2880
tgtcaagctg tcagaccctc cagcacaggt ttcagtgcca ttcatgtcac ctgcgagtgc 2940
ttatcaatgg ttttatgacg gatatcccac gttcggagaa cacaaacagg agaaagatct 3000
tgaatatggg gcatgtccta ataacatgat gggcacgttc tcagtgcgga ctgtagggtc 3060
ctccaagtcc aagtaccctc tagtgattag gatttacatg agaatgaagc acgtcagggc 3120
gtggatacct cgcccgatgc gtaaccagaa ctacctattc aaagccaatc caaattatgc 3180
tggcaactcc gttaagccaa ctggtgccag tcgcacagcg atcaccactc ttgggaaatt 3240
tggacaacag tctggggcta tttatgtggg caactttagg gtggtcaacc gacatcttgc 3300
cactcacaat gattgggcaa atcttgtttg ggaagacagc tctcgcgact tgctcgtgtc 3360
atccactacc gcccaaggtt gcgacacgat tgcccgctgc gattgccaga caggggtgta 3420
ctactgtaac tcgatgagaa aacactaccc agttagtttt tcaaaaccca gcctgatcta 3480
tgtagaggct agcgagtatt acccagccag gtaccaatca catctcatgc tcgcacaggg 3540
tcactcagaa cctggtgatt gcggtggtat ccttaggtgc caacatggcg tcgtcggcat 3600
agtgtccact ggtggtaatg ggcttgttgg ctttgcagac gtcagagacc tcttgtggtt 3660
agatgaagaa gccatggaac agggcgtgtc cgactacatc aagggtctcg gggatgcttt 3720
tggaacaggc tttactgacg cagtctcaag ggaggttgaa gctctcaaga actatctcat 3780
agggtctgaa ggagcagttg agaaaatttt gaaaaatcta attaaactaa tctctgcact 3840
ggtgattgtg atcagaagtg attatgatat ggttaccctc actgcgacct tggcgctgat 3900
aggttgtcat ggcagtccgt gggcttggat caaagccaaa acagcctcca tcttaggtat 3960
ccctattgct caaaagcaga gcgcttcctg gctcaagaag ttcaatgata tggccaacgc 4020
cgctaagggg ttagagtggg tttccaacaa gatcagcaaa tttattgatt ggcttaagga 4080
gaagatagta ccagcagcta gggagaaggt tgaattccta aataacttga aacagctgcc 4140
actgctagag aatcagatct caaacttgga acaatctgct gcctcacaag aggaccttga 4200
aatcatgttt gggaatgtat cgtacctagc tcacttctgc cgcaagttcc aaccgctata 4260
cgccacggaa gctaggagag tctatgccct ggagaagagg atgaataact atatgcagtt 4320
caagagcaaa caccgaattg aacctgtatg tctcatcatt aggggctcac caggcactgg 4380
gaagtctcta gccactggta ttattgctcg agcaatcgct gataagtacc actccagcgt 4440
gtactcgctc ccaccagacc cagatcattt tgacggttac aagcaacagg tggttaccgt 4500
gatggatgat ctgtgccaaa accccgacgg aaaggatatg tctttattct gtcaaatggt 4560
atccaccgta gacttcattc caccaatggc ttccctcgag gagaagggag tttccttcac 4620
ctctaagttt gtcatcgcat ccactaatgc cagtaatatc atagtaccaa cagtgtctga 4680
ttccgacgct attcgccgca ggttctacat ggactgtgac attgaagtga cagactcata 4740
caaaacagat ctaggtagac tggatgcagg gcgagccgct aaactgtgct ctgagaacaa 4800
cactgcaaat ttcaaacgtt gtagcccgtt agtgtgcggg aaagctatcc aacttagaga 4860
tagaaagtct aaagtcagat acagtgtgga tacggtggtt tcagaactta ttagggaata 4920
cagcaatagg tccgctattg gcaacacaat cgaggctctt ttccaaggtc cacccaagtt 4980
caggccaatt aggattagcc ttgaagaaaa accagcccca gacgctatta gcgatctcct 5040
tgctagcgta gatagtgaag aagtgcgcca gtactgcagg gatcaaggct ggattattcc 5100
tgaagttccc accaatgtag agcggcacct taatagagcg gtgcttgtca tgcaatccat 5160
cgccacagta gtggcagttg tctcgttggt gtatgtcatc tacaagctct ttgcagggtt 5220
ccagggtgcg tattctggtg ctcctaagca agtgcttaag aaacctgccc ttcgcacagc 5280
aacagtacag ggcccgagcc ttgactttgc tctctcccta ctgagaagga acatcagaca 5340
agttcaaaca gaccaggggc atttcaccat gttgggtgtt agggatcgct tagcagtcct 5400
tccacgtcac tcacaacctg gcaaaactat ttgggttgaa cacaaactcg tgaacgtcct 5460
tgatgcagtt gaactggtgg atgagcaagg agtcaacctg gaattgaccc tcattactct 5520
tgacaccaac gagaagttta gggatattac caagttcatc ccggaaaata ttagcactgc 5580
tagtgatgcc accctagtga tcaacacgga gcatatgcca tcaatgtttg tcccggtggg 5640
tgacgttgtg cagtatggct ttttgaatct cagtggtaag cctacccatc gcaccatgat 5700
gtacaacttt cctactaaag cagggcagtg tggaggagta gtgacatctg ttgggaaggt 5760
tgtcggtatt cacattggtg gcaatggcag acagggtttt tgcgcaggcc tcaaaaggag 5820
ttactttgct agtgaacaag gagagatcca atgggttaag cccaacaaag aaactggaag 5880
actcaacatt aatggaccaa cccgcaccaa attagaacct agtgtattcc atgacatctt 5940
cgagggaaat aaagagccag ctgtcttgca cagtaaagac ccccgacttg aagtagattt 6000
tgaacaggcc ctgttctcta agtatgtggg aaacacacta catgagcctg acgagtacat 6060
caaagaggcg gctcttcatt acgcgaacca attgaagcaa ttagaaatta atacctctca 6120
aatgagcatg gaagaggcct gctacggtac tgagaatctt gaggctattg atcttcacac 6180
tagtgcagga tacccttata gtgccttggg gataaagaaa agagacatct tagaccctac 6240
caccagggac gtgagtaaaa tgaagttcta catggacaag tatggtcttg atcttcctta 6300
ctccacttat gtcaaggacg agctacgctc gattgataaa attaagaaag ggaagtcccg 6360
tctgatcgag gctagtagtc taaatgattc agtgtacctc agaatggctt tcggacattt 6420
gtatgaggct ttccacgcaa atcctgggac aataactgga tcagccgtgg ggtgtaaccc 6480
tgacacattc tggagcaagc tgccaatttt gctccctggt tcactctttg ctttcgacta 6540
ctcaggttat gatgccagcc ttagccctgt ctggttcaga gcattagaat tagttctcag 6600
ggagataggg tatagtgaag aggcggtctc actcattgag ggaatcaacc acacacacca 6660
tgtgtatcgt aataagacct attgtgtgct tggtgggatg ccctcaggtt gttcgggaac 6720
atccattttc aactcaatga tcaacaacat tatcatcaga gcactgctca taaaaacatt 6780
taagggcatt gacttggatg aactcaacat ggtcgcttat ggagacgatg tgctcgctag 6840
ctatcccttc ccaattgatt gcttggaact agcaaagact ggtaaggagt atggtttgac 6900
catgactcct gctgataaat ctccttgctt caatgaggtt aattggggta atgcgacctt 6960
ccttaaaagg ggctttttgc ccgatgaaca gtttccgttc ttgattcacc ccactatgcc 7020
aatgagggag atccatgagt ccattcgatg gaccaaggac gcccgaaaca ctcaagatca 7080
tgtgcggtcc ttgtgcctcc tagcatggca taatggtaaa caagaatatg agaagtttgt 7140
gagcacaatt aggtctgttc cagtgggaag agcgttggct attccaaatt atgaaaacct 7200
tagacgcaat tggctcgagt tattttagag gttatacaca cctcaacccc accagaaatc 7260
tggtcgtgaa tgtgactggt gggggtaaat ttgttataac cagaatagca aaaaaaaaaa 7320
aaaaaaaaaa aaaa 7334
<210> 2
<211> 7321
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 2
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcatacgg 300
acatggtgtg aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa 360
tcccaactgc ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct 420
gcagcggaac cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta 480
tggtgacaat taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca 540
gagcaattat ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc 600
ttaattatat tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc 660
tccggttctc atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc 720
atcaattact acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat 780
ccagacaagt ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag 840
tccccatccg ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac 900
tccaccatca ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct 960
tactgctcag attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg 1020
aataggtttt acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg 1080
aagttcccgg atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac 1140
ctctaccgat cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga 1200
gcactcctag tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg 1260
acggaagata cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg 1320
cagcacccgt acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac 1380
cagtggatta atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca 1440
ctgccttttg attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt 1500
ccactagact acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca 1560
atgtgttctg agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta 1620
aaacctggca caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca 1680
aacttccacc ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta 1740
tgccaggtgg aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg 1800
gagagactgc gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt 1860
agagccgatc ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg 1920
tactacaccc aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg 1980
gctaccggca agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg 2040
gcgaccgcca tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc 2100
cttgtaatac catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt 2160
gactactaca ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt 2220
ggtgcgccca acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg 2280
aaattgtgca aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg 2340
gcagatgtaa ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta 2400
ccagcaccca caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt 2460
ccagcactcc aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt 2520
gagacacgct gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc 2580
agcagggcgg gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat 2640
ggttatgcca actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag 2700
ctcttcacct acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg 2760
gaagttgttc cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat 2820
tctagggaat cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca 2880
gaccctccag cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt 2940
tatgacggat atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca 3000
tgtcctaata acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag 3060
taccctctag tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc 3120
ccgatgcgta accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt 3180
aagccaactg gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct 3240
ggggctattt atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat 3300
tgggcaaatc ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc 3360
caaggttgcg acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg 3420
atgagaaaac actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc 3480
gagtattacc cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct 3540
ggtgattgcg gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt 3600
ggtaatgggc ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc 3660
atggaacagg gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt 3720
actgacgcag tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga 3780
gcagttgaga aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc 3840
agaagtgatt atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc 3900
agtccgtggg cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa 3960
aagcagagcg cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta 4020
gagtgggttt ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca 4080
gcagctaggg agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat 4140
cagatctcaa acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg 4200
aatgtatcgt acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct 4260
aggagagtct atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac 4320
cgaattgaac ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc 4380
actggtatta ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca 4440
ccagacccag atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg 4500
tgccaaaacc ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac 4560
ttcattccac caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc 4620
atcgcatcca ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt 4680
cgccgcaggt tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta 4740
ggtagactgg atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc 4800
aaacgttgta gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa 4860
gtcagataca gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc 4920
gctattggca acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg 4980
attagccttg aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat 5040
agtgaagaag tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc 5100
aatgtagagc ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg 5160
gcagttgtct cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat 5220
tctggtgctc ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc 5280
ccgagccttg actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac 5340
caggggcatt tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca 5400
caacctggca aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa 5460
ctggtggatg agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag 5520
aagtttaggg atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc 5580
ctagtgatca acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag 5640
tatggctttt tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct 5700
actaaagcag ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac 5760
attggtggca atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt 5820
gaacaaggag agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat 5880
ggaccaaccc gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa 5940
gagccagctg tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg 6000
ttctctaagt atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct 6060
cttcattacg cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa 6120
gaggcctgct acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac 6180
ccttatagtg ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg 6240
agtaaaatga agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc 6300
aaggacgagc tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct 6360
agtagtctaa atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc 6420
cacgcaaatc ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg 6480
agcaagctgc caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat 6540
gccagcctta gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat 6600
agtgaagagg cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat 6660
aagacctatt gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac 6720
tcaatgatca acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac 6780
ttggatgaac tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca 6840
attgattgct tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct 6900
gataaatctc cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc 6960
tttttgcccg atgaacagtt tccgttcttg attcacccca ctatgccaat gagggagatc 7020
catgagtcca ttcgatggac caaggacgcc cgaaacactc aagatcatgt gcggtccttg 7080
tgcctcctag catggcataa tggtaaacaa gaatatgaga agtttgtgag cacaattagg 7140
tctgttccag tgggaagagc gttggctatt ccaaattatg aaaaccttag acgcaattgg 7200
ctcgagttat tttagaggtt atacacacct caaccccacc agaaatctgg tcgtgaatgt 7260
gactggtggg ggtaaatttg ttataaccag aatagcaaaa aaaaaaaaaa aaaaaaaaaa 7320
a 7321
<210> 3
<211> 6282
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 3
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcatat gtttgtgcca cctggagccc caaagccaga ttctagggaa tcccttgcat 1800
ggcaaaccgc cactaacccc tcagtttttg tcaagctgtc agaccctcca gcacaggttt 1860
cagtgccatt catgtcacct gcgagtgctt atcaatggtt ttatgacgga tatcccacgt 1920
tcggagaaca caaacaggag aaagatcttg aatatggggc atgtcctaat aacatgatgg 1980
gcacgttctc agtgcggact gtagggtcct ccaagtccaa gtaccctcta gtgattagga 2040
tttacatgag aatgaagcac gtcagggcgt ggatacctcg cccgatgcgt aaccagaact 2100
acctattcaa agccaatcca aattatgctg gcaactccgt taagccaact ggtgccagtc 2160
gcacagcgat caccactctt gggaaatttg gacaacagtc tggggctatt tatgtgggca 2220
actttagggt ggtcaaccga catcttgcca ctcacaatga ttgggcaaat cttgtttggg 2280
aagacagctc tcgcgacttg ctcgtgtcat ccactaccgc ccaaggttgc gacacgattg 2340
cccgctgcga ttgccagaca ggggtgtact actgtaactc gatgagaaaa cactacccag 2400
ttagtttttc aaaacccagc ctgatctatg tagaggctag cgagtattac ccagccaggt 2460
accaatcaca tctcatgctc gcacagggtc actcagaacc tggtgattgc ggtggtatcc 2520
ttaggtgcca acatggcgtc gtcggcatag tgtccactgg tggtaatggg cttgttggct 2580
ttgcagacgt cagagacctc ttgtggttag atgaagaagc catggaacag ggcgtgtccg 2640
actacatcaa gggtctcggg gatgcttttg gaacaggctt tactgacgca gtctcaaggg 2700
aggttgaagc tctcaagaac tatctcatag ggtctgaagg agcagttgag aaaattttga 2760
aaaatctaat taaactaatc tctgcactgg tgattgtgat cagaagtgat tatgatatgg 2820
ttaccctcac tgcgaccttg gcgctgatag gttgtcatgg cagtccgtgg gcttggatca 2880
aagccaaaac agcctccatc ttaggtatcc ctattgctca aaagcagagc gcttcctggc 2940
tcaagaagtt caatgatatg gccaacgccg ctaaggggtt agagtgggtt tccaacaaga 3000
tcagcaaatt tattgattgg cttaaggaga agatagtacc agcagctagg gagaaggttg 3060
aattcctaaa taacttgaaa cagctgccac tgctagagaa tcagatctca aacttggaac 3120
aatctgctgc ctcacaagag gaccttgaaa tcatgtttgg gaatgtatcg tacctagctc 3180
acttctgccg caagttccaa ccgctatacg ccacggaagc taggagagtc tatgccctgg 3240
agaagaggat gaataactat atgcagttca agagcaaaca ccgaattgaa cctgtatgtc 3300
tcatcattag gggctcacca ggcactggga agtctctagc cactggtatt attgctcgag 3360
caatcgctga taagtaccac tccagcgtgt actcgctccc accagaccca gatcattttg 3420
acggttacaa gcaacaggtg gttaccgtga tggatgatct gtgccaaaac cccgacggaa 3480
aggatatgtc tttattctgt caaatggtat ccaccgtaga cttcattcca ccaatggctt 3540
ccctcgagga gaagggagtt tccttcacct ctaagtttgt catcgcatcc actaatgcca 3600
gtaatatcat agtaccaaca gtgtctgatt ccgacgctat tcgccgcagg ttctacatgg 3660
actgtgacat tgaagtgaca gactcataca aaacagatct aggtagactg gatgcagggc 3720
gagccgctaa actgtgctct gagaacaaca ctgcaaattt caaacgttgt agcccgttag 3780
tgtgcgggaa agctatccaa cttagagata gaaagtctaa agtcagatac agtgtggata 3840
cggtggtttc agaacttatt agggaataca gcaataggtc cgctattggc aacacaatcg 3900
aggctctttt ccaaggtcca cccaagttca ggccaattag gattagcctt gaagaaaaac 3960
cagccccaga cgctattagc gatctccttg ctagcgtaga tagtgaagaa gtgcgccagt 4020
actgcaggga tcaaggctgg attattcctg aagttcccac caatgtagag cggcacctta 4080
atagagcggt gcttgtcatg caatccatcg ccacagtagt ggcagttgtc tcgttggtgt 4140
atgtcatcta caagctcttt gcagggttcc agggtgcgta ttctggtgct cctaagcaag 4200
tgcttaagaa acctgccctt cgcacagcaa cagtacaggg cccgagcctt gactttgctc 4260
tctccctact gagaaggaac atcagacaag ttcaaacaga ccaggggcat ttcaccatgt 4320
tgggtgttag ggatcgctta gcagtccttc cacgtcactc acaacctggc aaaactattt 4380
gggttgaaca caaactcgtg aacgtccttg atgcagttga actggtggat gagcaaggag 4440
tcaacctgga attgaccctc attactcttg acaccaacga gaagtttagg gatattacca 4500
agttcatccc ggaaaatatt agcactgcta gtgatgccac cctagtgatc aacacggagc 4560
atatgccatc aatgtttgtc ccggtgggtg acgttgtgca gtatggcttt ttgaatctca 4620
gtggtaagcc tacccatcgc accatgatgt acaactttcc tactaaagca gggcagtgtg 4680
gaggagtagt gacatctgtt gggaaggttg tcggtattca cattggtggc aatggcagac 4740
agggtttttg cgcaggcctc aaaaggagtt actttgctag tgaacaagga gagatccaat 4800
gggttaagcc caacaaagaa actggaagac tcaacattaa tggaccaacc cgcaccaaat 4860
tagaacctag tgtattccat gacatcttcg agggaaataa agagccagct gtcttgcaca 4920
gtaaagaccc ccgacttgaa gtagattttg aacaggccct gttctctaag tatgtgggaa 4980
acacactaca tgagcctgac gagtacatca aagaggcggc tcttcattac gcgaaccaat 5040
tgaagcaatt agaaattaat acctctcaaa tgagcatgga agaggcctgc tacggtactg 5100
agaatcttga ggctattgat cttcacacta gtgcaggata cccttatagt gccttgggga 5160
taaagaaaag agacatctta gaccctacca ccagggacgt gagtaaaatg aagttctaca 5220
tggacaagta tggtcttgat cttccttact ccacttatgt caaggacgag ctacgctcga 5280
ttgataaaat taagaaaggg aagtcccgtc tgatcgaggc tagtagtcta aatgattcag 5340
tgtacctcag aatggctttc ggacatttgt atgaggcttt ccacgcaaat cctgggacaa 5400
taactggatc agccgtgggg tgtaaccctg acacattctg gagcaagctg ccaattttgc 5460
tccctggttc actctttgct ttcgactact caggttatga tgccagcctt agccctgtct 5520
ggttcagagc attagaatta gttctcaggg agatagggta tagtgaagag gcggtctcac 5580
tcattgaggg aatcaaccac acacaccatg tgtatcgtaa taagacctat tgtgtgcttg 5640
gtgggatgcc ctcaggttgt tcgggaacat ccattttcaa ctcaatgatc aacaacatta 5700
tcatcagagc actgctcata aaaacattta agggcattga cttggatgaa ctcaacatgg 5760
tcgcttatgg agacgatgtg ctcgctagct atcccttccc aattgattgc ttggaactag 5820
caaagactgg taaggagtat ggtttgacca tgactcctgc tgataaatct ccttgcttca 5880
atgaggttaa ttggggtaat gcgaccttcc ttaaaagggg ctttttgccc gatgaacagt 5940
ttccgttctt gattcacccc actatgccaa tgagggagat ccatgagtcc attcgatgga 6000
ccaaggacgc ccgaaacact caagatcatg tgcggtcctt gtgcctccta gcatggcata 6060
atggtaaaca agaatatgag aagtttgtga gcacaattag gtctgttcca gtgggaagag 6120
cgttggctat tccaaattat gaaaacctta gacgcaattg gctcgagtta ttttagaggt 6180
tatacacacc tcaaccccac cagaaatctg gtcgtgaatg tgactggtgg gggtaaattt 6240
gttataacca gaatagcaaa aaaaaaaaaa aaaaaaaaaa aa 6282
<210> 4
<211> 6289
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 4
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttatatgtt tgtgccacct ggagccccaa agccagattc tagggaatcc 1800
cttgcatggc aaaccgccac taacccctca gtttttgtca agctgtcaga ccctccagca 1860
caggtttcag tgccattcat gtcacctgcg agtgcttatc aatggtttta tgacggatat 1920
cccacgttcg gagaacacaa acaggagaaa gatcttgaat atggggcatg tcctaataac 1980
atgatgggca cgttctcagt gcggactgta gggtcctcca agtccaagta ccctctagtg 2040
attaggattt acatgagaat gaagcacgtc agggcgtgga tacctcgccc gatgcgtaac 2100
cagaactacc tattcaaagc caatccaaat tatgctggca actccgttaa gccaactggt 2160
gccagtcgca cagcgatcac cactcttggg aaatttggac aacagtctgg ggctatttat 2220
gtgggcaact ttagggtggt caaccgacat cttgccactc acaatgattg ggcaaatctt 2280
gtttgggaag acagctctcg cgacttgctc gtgtcatcca ctaccgccca aggttgcgac 2340
acgattgccc gctgcgattg ccagacaggg gtgtactact gtaactcgat gagaaaacac 2400
tacccagtta gtttttcaaa acccagcctg atctatgtag aggctagcga gtattaccca 2460
gccaggtacc aatcacatct catgctcgca cagggtcact cagaacctgg tgattgcggt 2520
ggtatcctta ggtgccaaca tggcgtcgtc ggcatagtgt ccactggtgg taatgggctt 2580
gttggctttg cagacgtcag agacctcttg tggttagatg aagaagccat ggaacagggc 2640
gtgtccgact acatcaaggg tctcggggat gcttttggaa caggctttac tgacgcagtc 2700
tcaagggagg ttgaagctct caagaactat ctcatagggt ctgaaggagc agttgagaaa 2760
attttgaaaa atctaattaa actaatctct gcactggtga ttgtgatcag aagtgattat 2820
gatatggtta ccctcactgc gaccttggcg ctgataggtt gtcatggcag tccgtgggct 2880
tggatcaaag ccaaaacagc ctccatctta ggtatcccta ttgctcaaaa gcagagcgct 2940
tcctggctca agaagttcaa tgatatggcc aacgccgcta aggggttaga gtgggtttcc 3000
aacaagatca gcaaatttat tgattggctt aaggagaaga tagtaccagc agctagggag 3060
aaggttgaat tcctaaataa cttgaaacag ctgccactgc tagagaatca gatctcaaac 3120
ttggaacaat ctgctgcctc acaagaggac cttgaaatca tgtttgggaa tgtatcgtac 3180
ctagctcact tctgccgcaa gttccaaccg ctatacgcca cggaagctag gagagtctat 3240
gccctggaga agaggatgaa taactatatg cagttcaaga gcaaacaccg aattgaacct 3300
gtatgtctca tcattagggg ctcaccaggc actgggaagt ctctagccac tggtattatt 3360
gctcgagcaa tcgctgataa gtaccactcc agcgtgtact cgctcccacc agacccagat 3420
cattttgacg gttacaagca acaggtggtt accgtgatgg atgatctgtg ccaaaacccc 3480
gacggaaagg atatgtcttt attctgtcaa atggtatcca ccgtagactt cattccacca 3540
atggcttccc tcgaggagaa gggagtttcc ttcacctcta agtttgtcat cgcatccact 3600
aatgccagta atatcatagt accaacagtg tctgattccg acgctattcg ccgcaggttc 3660
tacatggact gtgacattga agtgacagac tcatacaaaa cagatctagg tagactggat 3720
gcagggcgag ccgctaaact gtgctctgag aacaacactg caaatttcaa acgttgtagc 3780
ccgttagtgt gcgggaaagc tatccaactt agagatagaa agtctaaagt cagatacagt 3840
gtggatacgg tggtttcaga acttattagg gaatacagca ataggtccgc tattggcaac 3900
acaatcgagg ctcttttcca aggtccaccc aagttcaggc caattaggat tagccttgaa 3960
gaaaaaccag ccccagacgc tattagcgat ctccttgcta gcgtagatag tgaagaagtg 4020
cgccagtact gcagggatca aggctggatt attcctgaag ttcccaccaa tgtagagcgg 4080
caccttaata gagcggtgct tgtcatgcaa tccatcgcca cagtagtggc agttgtctcg 4140
ttggtgtatg tcatctacaa gctctttgca gggttccagg gtgcgtattc tggtgctcct 4200
aagcaagtgc ttaagaaacc tgcccttcgc acagcaacag tacagggccc gagccttgac 4260
tttgctctct ccctactgag aaggaacatc agacaagttc aaacagacca ggggcatttc 4320
accatgttgg gtgttaggga tcgcttagca gtccttccac gtcactcaca acctggcaaa 4380
actatttggg ttgaacacaa actcgtgaac gtccttgatg cagttgaact ggtggatgag 4440
caaggagtca acctggaatt gaccctcatt actcttgaca ccaacgagaa gtttagggat 4500
attaccaagt tcatcccgga aaatattagc actgctagtg atgccaccct agtgatcaac 4560
acggagcata tgccatcaat gtttgtcccg gtgggtgacg ttgtgcagta tggctttttg 4620
aatctcagtg gtaagcctac ccatcgcacc atgatgtaca actttcctac taaagcaggg 4680
cagtgtggag gagtagtgac atctgttggg aaggttgtcg gtattcacat tggtggcaat 4740
ggcagacagg gtttttgcgc aggcctcaaa aggagttact ttgctagtga acaaggagag 4800
atccaatggg ttaagcccaa caaagaaact ggaagactca acattaatgg accaacccgc 4860
accaaattag aacctagtgt attccatgac atcttcgagg gaaataaaga gccagctgtc 4920
ttgcacagta aagacccccg acttgaagta gattttgaac aggccctgtt ctctaagtat 4980
gtgggaaaca cactacatga gcctgacgag tacatcaaag aggcggctct tcattacgcg 5040
aaccaattga agcaattaga aattaatacc tctcaaatga gcatggaaga ggcctgctac 5100
ggtactgaga atcttgaggc tattgatctt cacactagtg caggataccc ttatagtgcc 5160
ttggggataa agaaaagaga catcttagac cctaccacca gggacgtgag taaaatgaag 5220
ttctacatgg acaagtatgg tcttgatctt ccttactcca cttatgtcaa ggacgagcta 5280
cgctcgattg ataaaattaa gaaagggaag tcccgtctga tcgaggctag tagtctaaat 5340
gattcagtgt acctcagaat ggctttcgga catttgtatg aggctttcca cgcaaatcct 5400
gggacaataa ctggatcagc cgtggggtgt aaccctgaca cattctggag caagctgcca 5460
attttgctcc ctggttcact ctttgctttc gactactcag gttatgatgc cagccttagc 5520
cctgtctggt tcagagcatt agaattagtt ctcagggaga tagggtatag tgaagaggcg 5580
gtctcactca ttgagggaat caaccacaca caccatgtgt atcgtaataa gacctattgt 5640
gtgcttggtg ggatgccctc aggttgttcg ggaacatcca ttttcaactc aatgatcaac 5700
aacattatca tcagagcact gctcataaaa acatttaagg gcattgactt ggatgaactc 5760
aacatggtcg cttatggaga cgatgtgctc gctagctatc ccttcccaat tgattgcttg 5820
gaactagcaa agactggtaa ggagtatggt ttgaccatga ctcctgctga taaatctcct 5880
tgcttcaatg aggttaattg gggtaatgcg accttcctta aaaggggctt tttgcccgat 5940
gaacagtttc cgttcttgat tcaccccact atgccaatga gggagatcca tgagtccatt 6000
cgatggacca aggacgcccg aaacactcaa gatcatgtgc ggtccttgtg cctcctagca 6060
tggcataatg gtaaacaaga atatgagaag tttgtgagca caattaggtc tgttccagtg 6120
ggaagagcgt tggctattcc aaattatgaa aaccttagac gcaattggct cgagttattt 6180
tagaggttat acacacctca accccaccag aaatctggtc gtgaatgtga ctggtggggg 6240
taaatttgtt ataaccagaa tagcaaaaaa aaaaaaaaaa aaaaaaaaa 6289
<210> 5
<211> 6288
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 5
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt ctatatgttt gtgccacctg gagccccaaa gccagattct agggaatccc 1800
ttgcatggca aaccgccact aacccctcag tttttgtcaa gctgtcagac cctccagcac 1860
aggtttcagt gccattcatg tcacctgcga gtgcttatca atggttttat gacggatatc 1920
ccacgttcgg agaacacaaa caggagaaag atcttgaata tggggcatgt cctaataaca 1980
tgatgggcac gttctcagtg cggactgtag ggtcctccaa gtccaagtac cctctagtga 2040
ttaggattta catgagaatg aagcacgtca gggcgtggat acctcgcccg atgcgtaacc 2100
agaactacct attcaaagcc aatccaaatt atgctggcaa ctccgttaag ccaactggtg 2160
ccagtcgcac agcgatcacc actcttggga aatttggaca acagtctggg gctatttatg 2220
tgggcaactt tagggtggtc aaccgacatc ttgccactca caatgattgg gcaaatcttg 2280
tttgggaaga cagctctcgc gacttgctcg tgtcatccac taccgcccaa ggttgcgaca 2340
cgattgcccg ctgcgattgc cagacagggg tgtactactg taactcgatg agaaaacact 2400
acccagttag tttttcaaaa cccagcctga tctatgtaga ggctagcgag tattacccag 2460
ccaggtacca atcacatctc atgctcgcac agggtcactc agaacctggt gattgcggtg 2520
gtatccttag gtgccaacat ggcgtcgtcg gcatagtgtc cactggtggt aatgggcttg 2580
ttggctttgc agacgtcaga gacctcttgt ggttagatga agaagccatg gaacagggcg 2640
tgtccgacta catcaagggt ctcggggatg cttttggaac aggctttact gacgcagtct 2700
caagggaggt tgaagctctc aagaactatc tcatagggtc tgaaggagca gttgagaaaa 2760
ttttgaaaaa tctaattaaa ctaatctctg cactggtgat tgtgatcaga agtgattatg 2820
atatggttac cctcactgcg accttggcgc tgataggttg tcatggcagt ccgtgggctt 2880
ggatcaaagc caaaacagcc tccatcttag gtatccctat tgctcaaaag cagagcgctt 2940
cctggctcaa gaagttcaat gatatggcca acgccgctaa ggggttagag tgggtttcca 3000
acaagatcag caaatttatt gattggctta aggagaagat agtaccagca gctagggaga 3060
aggttgaatt cctaaataac ttgaaacagc tgccactgct agagaatcag atctcaaact 3120
tggaacaatc tgctgcctca caagaggacc ttgaaatcat gtttgggaat gtatcgtacc 3180
tagctcactt ctgccgcaag ttccaaccgc tatacgccac ggaagctagg agagtctatg 3240
ccctggagaa gaggatgaat aactatatgc agttcaagag caaacaccga attgaacctg 3300
tatgtctcat cattaggggc tcaccaggca ctgggaagtc tctagccact ggtattattg 3360
ctcgagcaat cgctgataag taccactcca gcgtgtactc gctcccacca gacccagatc 3420
attttgacgg ttacaagcaa caggtggtta ccgtgatgga tgatctgtgc caaaaccccg 3480
acggaaagga tatgtcttta ttctgtcaaa tggtatccac cgtagacttc attccaccaa 3540
tggcttccct cgaggagaag ggagtttcct tcacctctaa gtttgtcatc gcatccacta 3600
atgccagtaa tatcatagta ccaacagtgt ctgattccga cgctattcgc cgcaggttct 3660
acatggactg tgacattgaa gtgacagact catacaaaac agatctaggt agactggatg 3720
cagggcgagc cgctaaactg tgctctgaga acaacactgc aaatttcaaa cgttgtagcc 3780
cgttagtgtg cgggaaagct atccaactta gagatagaaa gtctaaagtc agatacagtg 3840
tggatacggt ggtttcagaa cttattaggg aatacagcaa taggtccgct attggcaaca 3900
caatcgaggc tcttttccaa ggtccaccca agttcaggcc aattaggatt agccttgaag 3960
aaaaaccagc cccagacgct attagcgatc tccttgctag cgtagatagt gaagaagtgc 4020
gccagtactg cagggatcaa ggctggatta ttcctgaagt tcccaccaat gtagagcggc 4080
accttaatag agcggtgctt gtcatgcaat ccatcgccac agtagtggca gttgtctcgt 4140
tggtgtatgt catctacaag ctctttgcag ggttccaggg tgcgtattct ggtgctccta 4200
agcaagtgct taagaaacct gcccttcgca cagcaacagt acagggcccg agccttgact 4260
ttgctctctc cctactgaga aggaacatca gacaagttca aacagaccag gggcatttca 4320
ccatgttggg tgttagggat cgcttagcag tccttccacg tcactcacaa cctggcaaaa 4380
ctatttgggt tgaacacaaa ctcgtgaacg tccttgatgc agttgaactg gtggatgagc 4440
aaggagtcaa cctggaattg accctcatta ctcttgacac caacgagaag tttagggata 4500
ttaccaagtt catcccggaa aatattagca ctgctagtga tgccacccta gtgatcaaca 4560
cggagcatat gccatcaatg tttgtcccgg tgggtgacgt tgtgcagtat ggctttttga 4620
atctcagtgg taagcctacc catcgcacca tgatgtacaa ctttcctact aaagcagggc 4680
agtgtggagg agtagtgaca tctgttggga aggttgtcgg tattcacatt ggtggcaatg 4740
gcagacaggg tttttgcgca ggcctcaaaa ggagttactt tgctagtgaa caaggagaga 4800
tccaatgggt taagcccaac aaagaaactg gaagactcaa cattaatgga ccaacccgca 4860
ccaaattaga acctagtgta ttccatgaca tcttcgaggg aaataaagag ccagctgtct 4920
tgcacagtaa agacccccga cttgaagtag attttgaaca ggccctgttc tctaagtatg 4980
tgggaaacac actacatgag cctgacgagt acatcaaaga ggcggctctt cattacgcga 5040
accaattgaa gcaattagaa attaatacct ctcaaatgag catggaagag gcctgctacg 5100
gtactgagaa tcttgaggct attgatcttc acactagtgc aggataccct tatagtgcct 5160
tggggataaa gaaaagagac atcttagacc ctaccaccag ggacgtgagt aaaatgaagt 5220
tctacatgga caagtatggt cttgatcttc cttactccac ttatgtcaag gacgagctac 5280
gctcgattga taaaattaag aaagggaagt cccgtctgat cgaggctagt agtctaaatg 5340
attcagtgta cctcagaatg gctttcggac atttgtatga ggctttccac gcaaatcctg 5400
ggacaataac tggatcagcc gtggggtgta accctgacac attctggagc aagctgccaa 5460
ttttgctccc tggttcactc tttgctttcg actactcagg ttatgatgcc agccttagcc 5520
ctgtctggtt cagagcatta gaattagttc tcagggagat agggtatagt gaagaggcgg 5580
tctcactcat tgagggaatc aaccacacac accatgtgta tcgtaataag acctattgtg 5640
tgcttggtgg gatgccctca ggttgttcgg gaacatccat tttcaactca atgatcaaca 5700
acattatcat cagagcactg ctcataaaaa catttaaggg cattgacttg gatgaactca 5760
acatggtcgc ttatggagac gatgtgctcg ctagctatcc cttcccaatt gattgcttgg 5820
aactagcaaa gactggtaag gagtatggtt tgaccatgac tcctgctgat aaatctcctt 5880
gcttcaatga ggttaattgg ggtaatgcga ccttccttaa aaggggcttt ttgcccgatg 5940
aacagtttcc gttcttgatt caccccacta tgccaatgag ggagatccat gagtccattc 6000
gatggaccaa ggacgcccga aacactcaag atcatgtgcg gtccttgtgc ctcctagcat 6060
ggcataatgg taaacaagaa tatgagaagt ttgtgagcac aattaggtct gttccagtgg 6120
gaagagcgtt ggctattcca aattatgaaa accttagacg caattggctc gagttatttt 6180
agaggttata cacacctcaa ccccaccaga aatctggtcg tgaatgtgac tggtgggggt 6240
aaatttgtta taaccagaat agcaaaaaaa aaaaaaaaaa aaaaaaaa 6288
<210> 6
<211> 6288
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 6
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt ctatatgttt gtgccacctg gagccccaaa gccagattct agggaatccc 1800
ttgcatggca aaccgccact aacccctcag tttttgtcaa gctgtcagac cctccagcac 1860
aggtttcagt gccattcatg tcacctgcga gtgcttatca atggttttat gacggatatc 1920
ccacgttcgg agaacacaaa caggagaaag atcttgaata tggggcatgt cctaataaca 1980
tgatgggcac gttctcagtg cggactgtag ggtcctccaa gtccaagtac cctctagtga 2040
ttaggattta catgagaatg aagcacgtca gggcgtggat acctcgcccg atgcgtaacc 2100
agaactacct attcaaagcc aatccaaatt atgctggcaa ctccgttaag ccaactggtg 2160
ccagtcgcac agcgatcacc actcttggga aatttggaca acagtctggg gctatttatg 2220
tgggcaactt tagggtggtc aaccgacatc ttgccactca caatgattgg gcaaatcttg 2280
tttgggaaga cagctctcgc gacttgctcg tgtcatccac taccgcccaa ggttgcgaca 2340
cgattgcccg ctgcgattgc cagacagggg tgtactactg taactcgatg agaaaacact 2400
acccagttag tttttcaaaa cccagcctga tctatgtaga ggctagcgag tattacccag 2460
ccaggtacca atcacatctc atgctcgcac agggtcactc agaacctggt gattgcggtg 2520
gtatccttag gtgccaacat ggcgtcgtcg gcatagtgtc cactggtggt aatgggcttg 2580
ttggctttgc agacgtcaga gacctcttgt ggttagatga agaagccatg gaacagggcg 2640
tgtccgacta catcaagggt ctcggggatg cttttggaac aggctttact gacgcagtct 2700
caagggaggt tgaagctctc aagaactatc tcatagggtc tgaaggagca gttgagaaaa 2760
ttttgaaaaa tctaattaaa ctaatctctg cactggtgat tgtgatcaga agtgattatg 2820
atatggttac cctcactgcg accttggcgc tgataggttg tcatggcagt ccgtgggctt 2880
ggatcaaagc caaaacagcc tccatcttag gtatccctat tgctcaaaag cagagcgctt 2940
cctggctcaa gaagttcaat gatatggcca acgccgctaa ggggttagag tgggtttcca 3000
acaagatcag caaatttatt gattggctta aggagaagat agtaccagca gctagggaga 3060
aggttgaatt cctaaataac ttgaaacagc tgccactgct agagaatcag atctcaaact 3120
tggaacaatc tgctgcctca caagaggacc ttgaaatcat gtttgggaat gtatcgtacc 3180
tagctcactt ctgccgcaag ttccaaccgc tatacgccac ggaagctagg agagtctatg 3240
ccctggagaa gaggatgaat aactatatgc agttcaagag caaacaccga attgaacctg 3300
tatgtctcat cattaggggc tcaccaggca ctgggaagtc tctagccact ggtattattg 3360
ctcgagcaat cgctgataag taccactcca gcgtgtactc gctcccacca gacccagatc 3420
attttgacgg ttacaagcaa caggtggtta ccgtgatgga tgatctgtgc caaaaccccg 3480
acggaaagga tatgtcttta ttctgtcaaa tggtatccac cgtagacttc attccaccaa 3540
tggcttccct cgaggagaag ggagtttcct tcacctctaa gtttgtcatc gcatccacta 3600
atgccagtaa tatcatagta ccaacagtgt ctgattccga cgctattcgc cgcaggttct 3660
acatggactg tgacattgaa gtgacagact catacaaaac agatctaggt agactggatg 3720
cagggcgagc cgctaaactg tgctctgaga acaacactgc aaatttcaaa cgttgtagcc 3780
cgttagtgtg cgggaaagct atccaactta gagatagaaa gtctaaagtc agatacagtg 3840
tggatacggt ggtttcagaa cttattaggg aatacagcaa taggtccgct attggcaaca 3900
caatcgaggc tcttttccaa ggtccaccca agttcaggcc aattaggatt agccttgaag 3960
aaaaaccagc cccagacgct attagcgatc tccttgctag cgtagatagt gaagaagtgc 4020
gccagtactg cagggatcaa ggctggatta ttcctgaagt tcccaccaat gtagagcggc 4080
accttaatag agcggtgctt gtcatgcaat ccatcgccac agtagtggca gttgtctcgt 4140
tggtgtatgt catctacaag ctctttgcag ggttccaggg tgcgtattct ggtgctccta 4200
agcaagtgct taagaaacct gcccttcgca cagcaacagt acagggcccg agccttgact 4260
ttgctctctc cctactgaga aggaacatca gacaagttca aacagaccag gggcatttca 4320
ccatgttggg tgttagggat cgcttagcag tccttccacg tcactcacaa cctggcaaaa 4380
ctatttgggt tgaacacaaa ctcgtgaacg tccttgatgc agttgaactg gtggatgagc 4440
aaggagtcaa cctggaattg accctcatta ctcttgacac caacgagaag tttagggata 4500
ttaccaagtt catcccggaa aatattagca ctgctagtga tgccacccta gtgatcaaca 4560
cggagcatat gccatcaatg tttgtcccgg tgggtgacgt tgtgcagtat ggctttttga 4620
atctcagtgg taagcctacc catcgcacca tgatgtacaa ctttcctact aaagcagggc 4680
agtgtggagg agtagtgaca tctgttggga aggttgtcgg tattcacatt ggtggcaatg 4740
gcagacaggg tttttgcgca ggcctcaaaa ggagttactt tgctagtgaa caaggagaga 4800
tccaatgggt taagcccaac aaagaaactg gaagactcaa cattaatgga ccaacccgca 4860
ccaaattaga acctagtgta ttccatgaca tcttcgaggg aaataaagag ccagctgtct 4920
tgcacagtaa agacccccga cttgaagtag attttgaaca ggccctgttc tctaagtatg 4980
tgggaaacac actacatgag cctgacgagt acatcaaaga ggcggctctt cattacgcga 5040
accaattgaa gcaattagaa attaatacct ctcaaatgag catggaagag gcctgctacg 5100
gtactgagaa tcttgaggct attgatcttc acactagtgc aggataccct tatagtgcct 5160
tggggataaa gaaaagagac atcttagacc ctaccaccag ggacgtgagt aaaatgaagt 5220
tctacatgga caagtatggt cttgatcttc cttactccac ttatgtcaag gacgagctac 5280
gctcgattga taaaattaag aaagggaagt cccgtctgat cgaggctagt agtctaaatg 5340
attcagtgta cctcagaatg gctttcggac atttgtatga ggctttccac gcaaatcctg 5400
ggacaataac tggatcagcc gtggggtgta accctgacac attctggagc aagctgccaa 5460
ttttgctccc tggttcactc tttgctttcg actactcagg ttatgatgcc agccttagcc 5520
ctgtctggtt cagagcatta gaattagttc tcagggagat agggtatagt gaagaggcgg 5580
tctcactcat tgagggaatc aaccacacac accatgtgta tcgtaataag acctattgtg 5640
tgcttggtgg gatgccctca ggttgttcgg gaacatccat tttcaactca atgatcaaca 5700
acattatcat cagagcactg ctcataaaaa catttaaggg cattgacttg gatgaactca 5760
acatggtcgc ttatggagac gatgtgctcg ctagctatcc cttcccaatt gattgcttgg 5820
aactagcaaa gactggtaag gagtatggtt tgaccatgac tcctgctgat aaatctcctt 5880
gcttcaatga ggttaattgg ggtaatgcga ccttccttaa aaggggcttt ttgcccgatg 5940
aacagtttcc gttcttgatt caccccacta tgccaatgag ggagatccat gagtccattc 6000
gatggaccaa ggacgcccga aacactcaag atcatgtgcg gtccttgtgc ctcctagcat 6060
ggcataatgg taaacaagaa tatgagaagt ttgtgagcac aattaggtct gttccagtgg 6120
gaagagcgtt ggctattcca aattatgaaa accttagacg caattggctc gagttatttt 6180
agaggttata cacacctcaa ccccaccaga aatctggtcg tgaatgtgac tggtgggggt 6240
aaatttgtta taaccagaat agcaaaaaaa aaaaaaaaaa aaaaaaaa 6288
<210> 7
<211> 2823
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 7
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat gtgtacctca gaatggcttt cggacatttg tatgaggctt 1920
tccacgcaaa tcctgggaca ataactggat cagccgtggg gtgtaaccct gacacattct 1980
ggagcaagct gccaattttg ctccctggtt cactctttgc tttcgactac tcaggttatg 2040
atgccagcct tagccctgtc tggttcagag cattagaatt agttctcagg gagatagggt 2100
atagtgaaga ggcggtctca ctcattgagg gaatcaacca cacacaccat gtgtatcgta 2160
ataagaccta ttgtgtgctt ggtgggatgc cctcaggttg ttcgggaaca tccattttca 2220
actcaatgat caacaacatt atcatcagag cactgctcat aaaaacattt aagggcattg 2280
acttggatga actcaacatg gtcgcttatg gagacgatgt gctcgctagc tatcccttcc 2340
caattgattg cttggaacta gcaaagactg gtaaggagta tggtttgacc atgactcctg 2400
ctgataaatc tccttgcttc aatgaggtta attggggtaa tgcgaccttc cttaaaaggg 2460
gctttttgcc cgatgaacag tttccgttct tgattcaccc cactatgcca atgagggaga 2520
tccatgagtc cattcgatgg accaaggacg cccgaaacac tcaagatcat gtgcggtcct 2580
tgtgcctcct agcatggcat aatggtaaac aagaatatga gaagtttgtg agcacaatta 2640
ggtctgttcc agtgggaaga gcgttggcta ttccaaatta tgaaaacctt agacgcaatt 2700
ggctcgagtt attttagagg ttatacacac ctcaacccca ccagaaatct ggtcgtgaat 2760
gtgactggtg ggggtaaatt tgttataacc agaatagcaa aaaaaaaaaa aaaaaaaaaa 2820
aaa 2823
<210> 8
<211> 4428
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 8
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtatga ggctttccac gcaaatcctg 3540
ggacaataac tggatcagcc gtggggtgta accctgacac attctggagc aagctgccaa 3600
ttttgctccc tggttcactc tttgctttcg actactcagg ttatgatgcc agccttagcc 3660
ctgtctggtt cagagcatta gaattagttc tcagggagat agggtatagt gaagaggcgg 3720
tctcactcat tgagggaatc aaccacacac accatgtgta tcgtaataag acctattgtg 3780
tgcttggtgg gatgccctca ggttgttcgg gaacatccat tttcaactca atgatcaaca 3840
acattatcat cagagcactg ctcataaaaa catttaaggg cattgacttg gatgaactca 3900
acatggtcgc ttatggagac gatgtgctcg ctagctatcc cttcccaatt gattgcttgg 3960
aactagcaaa gactggtaag gagtatggtt tgaccatgac tcctgctgat aaatctcctt 4020
gcttcaatga ggttaattgg ggtaatgcga ccttccttaa aaggggcttt ttgcccgatg 4080
aacagtttcc gttcttgatt caccccacta tgccaatgag ggagatccat gagtccattc 4140
gatggaccaa ggacgcccga aacactcaag atcatgtgcg gtccttgtgc ctcctagcat 4200
ggcataatgg taaacaagaa tatgagaagt ttgtgagcac aattaggtct gttccagtgg 4260
gaagagcgtt ggctattcca aattatgaaa accttagacg caattggctc gagttatttt 4320
agaggttata cacacctcaa ccccaccaga aatctggtcg tgaatgtgac tggtgggggt 4380
aaatttgtta taaccagaat agcaaaaaaa aaaaaaaaaa aaaaaaaa 4428
<210> 9
<211> 7272
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 9
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatattacca agttcatccc ggaaaatatt agcactgcta 5520
gtgatgccac cctagtgatc aacacggagc atatgccatc aatgtttgtc ccggtgggtg 5580
acgttgtgca gtatggcttt ttgaatctca gtggtaagcc tacccatcgc accatgatgt 5640
acaactttcc tactaaagca gggcagtgtg gaggagtagt gacatctgtt gggaaggttg 5700
tcggtattca cattggtggc aatggcagac agggtttttg cgcaggcctc aaaaggagtt 5760
actttgctag tgaacaagga gagatccaat gggttaagcc caacaaagaa actggaagac 5820
tcaacattaa tggaccaacc cgcaccaaat tagaacctag tgtattccat gacatcttcg 5880
agggaaataa agagccagct gtcttgcaca gtaaagaccc ccgacttgaa gtagattttg 5940
aacaggccct gttctctaag tatgtgggaa acacactaca tgagcctgac gagtacatca 6000
aagaggcggc tcttcattac gcgaaccaat tgaagcaatt agaaattaat acctctcaaa 6060
tgagcatgga agaggcctgc tacggtactg agaatcttga ggctattgat cttcacacta 6120
gtgcaggata cccttatagt gccttgggga taaagaaaag agacatctta gaccctacca 6180
ccagggacgt gagtaaaatg aagttctaca tggacaagta tggtcttgat cttccttact 6240
ccacttatgt caaggacgag ctacgctcga ttgataaaat taagaaaggg aagtcccgtc 6300
tgatcgaggc tagtagtcta aatgattcag tgtacctcag aatggctttc ggacatttgt 6360
atgaggcttt ccacgcaaat cctgggacaa taactggatc agccgtgggg tgtaaccctg 6420
acacattctg gagcaagctg ccaattttgc tccctggttc actctttgct ttcgactact 6480
caggttatga tgccagcctt agccctgtct ggttcagagc attagaatta gttctcaggg 6540
agatagggta tagtgaagag gcggtctcac tcattgaggg aatcaaccac acacaccatg 6600
tgtatcgtaa taagacctat tgtgtgcttg gtgggatgcc ctcaggttgt tcgggaacat 6660
ccattttcaa ctcaatgatc aacaacatta tcatcagagc actgctcata aaaacattta 6720
agggcattga cttggatgaa ctcaacatgg tcgcttatgg agacgatgtg ctcgctagct 6780
atcccttccc aattgattgc ttggaactag caaagactgg taaggagtat ggtttgacca 6840
tgactcctgc tgataaatct ccttgcttca atgaggttaa ttggggtaat gcgaccttcc 6900
ttaaaagggg ctttttgccc gatgaacagt ttccgttctt gattcacccc actatgccaa 6960
tgagggagat ccatgagtcc attcgatgga ccaaggacgc ccgaaacact caagatcatg 7020
tgcggtcctt gtgcctccta gcatggcata atggtaaaca agaatatgag aagtttgtga 7080
gcacaattag gtctgttcca gtgggaagag cgttggctat tccaaattat gaaaacctta 7140
gacgcaattg gctcgagtta ttttagaggt tatacacacc tcaaccccac cagaaatctg 7200
gtcgtgaatg tgactggtgg gggtaaattt gttataacca gaatagcaaa aaaaaaaaaa 7260
aaaaaaaaaa aa 7272
<210> 10
<211> 7165
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 10
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ggcaatggca gacagggttt ttgcgcaggc 5640
ctcaaaagga gttactttgc tagtgaacaa ggagagatcc aatgggttaa gcccaacaaa 5700
gaaactggaa gactcaacat taatggacca acccgcacca aattagaacc tagtgtattc 5760
catgacatct tcgagggaaa taaagagcca gctgtcttgc acagtaaaga cccccgactt 5820
gaagtagatt ttgaacaggc cctgttctct aagtatgtgg gaaacacact acatgagcct 5880
gacgagtaca tcaaagaggc ggctcttcat tacgcgaacc aattgaagca attagaaatt 5940
aatacctctc aaatgagcat ggaagaggcc tgctacggta ctgagaatct tgaggctatt 6000
gatcttcaca ctagtgcagg atacccttat agtgccttgg ggataaagaa aagagacatc 6060
ttagacccta ccaccaggga cgtgagtaaa atgaagttct acatggacaa gtatggtctt 6120
gatcttcctt actccactta tgtcaaggac gagctacgct cgattgataa aattaagaaa 6180
gggaagtccc gtctgatcga ggctagtagt ctaaatgatt cagtgtacct cagaatggct 6240
ttcggacatt tgtatgaggc tttccacgca aatcctggga caataactgg atcagccgtg 6300
gggtgtaacc ctgacacatt ctggagcaag ctgccaattt tgctccctgg ttcactcttt 6360
gctttcgact actcaggtta tgatgccagc cttagccctg tctggttcag agcattagaa 6420
ttagttctca gggagatagg gtatagtgaa gaggcggtct cactcattga gggaatcaac 6480
cacacacacc atgtgtatcg taataagacc tattgtgtgc ttggtgggat gccctcaggt 6540
tgttcgggaa catccatttt caactcaatg atcaacaaca ttatcatcag agcactgctc 6600
ataaaaacat ttaagggcat tgacttggat gaactcaaca tggtcgctta tggagacgat 6660
gtgctcgcta gctatccctt cccaattgat tgcttggaac tagcaaagac tggtaaggag 6720
tatggtttga ccatgactcc tgctgataaa tctccttgct tcaatgaggt taattggggt 6780
aatgcgacct tccttaaaag gggctttttg cccgatgaac agtttccgtt cttgattcac 6840
cccactatgc caatgaggga gatccatgag tccattcgat ggaccaagga cgcccgaaac 6900
actcaagatc atgtgcggtc cttgtgcctc ctagcatggc ataatggtaa acaagaatat 6960
gagaagtttg tgagcacaat taggtctgtt ccagtgggaa gagcgttggc tattccaaat 7020
tatgaaaacc ttagacgcaa ttggctcgag ttattttaga ggttatacac acctcaaccc 7080
caccagaaat ctggtcgtga atgtgactgg tgggggtaaa tttgttataa ccagaatagc 7140
aaaaaaaaaa aaaaaaaaaa aaaaa 7165
<210> 11
<211> 7164
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 11
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca gcaatggcag acagggtttt tgcgcaggcc 5640
tcaaaaggag ttactttgct agtgaacaag gagagatcca atgggttaag cccaacaaag 5700
aaactggaag actcaacatt aatggaccaa cccgcaccaa attagaacct agtgtattcc 5760
atgacatctt cgagggaaat aaagagccag ctgtcttgca cagtaaagac ccccgacttg 5820
aagtagattt tgaacaggcc ctgttctcta agtatgtggg aaacacacta catgagcctg 5880
acgagtacat caaagaggcg gctcttcatt acgcgaacca attgaagcaa ttagaaatta 5940
atacctctca aatgagcatg gaagaggcct gctacggtac tgagaatctt gaggctattg 6000
atcttcacac tagtgcagga tacccttata gtgccttggg gataaagaaa agagacatct 6060
tagaccctac caccagggac gtgagtaaaa tgaagttcta catggacaag tatggtcttg 6120
atcttcctta ctccacttat gtcaaggacg agctacgctc gattgataaa attaagaaag 6180
ggaagtcccg tctgatcgag gctagtagtc taaatgattc agtgtacctc agaatggctt 6240
tcggacattt gtatgaggct ttccacgcaa atcctgggac aataactgga tcagccgtgg 6300
ggtgtaaccc tgacacattc tggagcaagc tgccaatttt gctccctggt tcactctttg 6360
ctttcgacta ctcaggttat gatgccagcc ttagccctgt ctggttcaga gcattagaat 6420
tagttctcag ggagataggg tatagtgaag aggcggtctc actcattgag ggaatcaacc 6480
acacacacca tgtgtatcgt aataagacct attgtgtgct tggtgggatg ccctcaggtt 6540
gttcgggaac atccattttc aactcaatga tcaacaacat tatcatcaga gcactgctca 6600
taaaaacatt taagggcatt gacttggatg aactcaacat ggtcgcttat ggagacgatg 6660
tgctcgctag ctatcccttc ccaattgatt gcttggaact agcaaagact ggtaaggagt 6720
atggtttgac catgactcct gctgataaat ctccttgctt caatgaggtt aattggggta 6780
atgcgacctt ccttaaaagg ggctttttgc ccgatgaaca gtttccgttc ttgattcacc 6840
ccactatgcc aatgagggag atccatgagt ccattcgatg gaccaaggac gcccgaaaca 6900
ctcaagatca tgtgcggtcc ttgtgcctcc tagcatggca taatggtaaa caagaatatg 6960
agaagtttgt gagcacaatt aggtctgttc cagtgggaag agcgttggct attccaaatt 7020
atgaaaacct tagacgcaat tggctcgagt tattttagag gttatacaca cctcaacccc 7080
accagaaatc tggtcgtgaa tgtgactggt gggggtaaat ttgttataac cagaatagca 7140
aaaaaaaaaa aaaaaaaaaa aaaa 7164
<210> 12
<211> 7356
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 12
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tgtggaggag 5760
tagtgacatc tgttgggaag gttgtcggta ttcacattgg tggcaatggc agacagggtt 5820
tttgcgcagg cctcaaaagg agttactttg ctagtgaaca aggagagatc caatgggtta 5880
agcccaacaa agaaactgga agactcaaca ttaatggacc aacccgcacc aaattagaac 5940
ctagtgtatt ccatgacatc ttcgagggaa ataaagagcc agctgtcttg cacagtaaag 6000
acccccgact tgaagtagat tttgaacagg ccctgttctc taagtatgtg ggaaacacac 6060
tacatgagcc tgacgagtac atcaaagagg cggctcttca ttacgcgaac caattgaagc 6120
aattagaaat taatacctct caaatgagca tggaagaggc ctgctacggt actgagaatc 6180
ttgaggctat tgatcttcac actagtgcag gataccctta tagtgccttg gggataaaga 6240
aaagagacat cttagaccct accaccaggg acgtgagtaa aatgaagttc tacatggaca 6300
agtatggtct tgatcttcct tactccactt atgtcaagga cgagctacgc tcgattgata 6360
aaattaagaa agggaagtcc cgtctgatcg aggctagtag tctaaatgat tcagtgtacc 6420
tcagaatggc tttcggacat ttgtatgagg ctttccacgc aaatcctggg acaataactg 6480
gatcagccgt ggggtgtaac cctgacacat tctggagcaa gctgccaatt ttgctccctg 6540
gttcactctt tgctttcgac tactcaggtt atgatgccag ccttagccct gtctggttca 6600
gagcattaga attagttctc agggagatag ggtatagtga agaggcggtc tcactcattg 6660
agggaatcaa ccacacacac catgtgtatc gtaataagac ctattgtgtg cttggtggga 6720
tgccctcagg ttgttcggga acatccattt tcaactcaat gatcaacaac attatcatca 6780
gagcactgct cataaaaaca tttaagggca ttgacttgga tgaactcaac atggtcgctt 6840
atggagacga tgtgctcgct agctatccct tcccaattga ttgcttggaa ctagcaaaga 6900
ctggtaagga gtatggtttg accatgactc ctgctgataa atctccttgc ttcaatgagg 6960
ttaattgggg taatgcgacc ttccttaaaa ggggcttttt gcccgatgaa cagtttccgt 7020
tcttgattca ccccactatg ccaatgaggg agatccatga gtccattcga tggaccaagg 7080
acgcccgaaa cactcaagat catgtgcggt ccttgtgcct cctagcatgg cataatggta 7140
aacaagaata tgagaagttt gtgagcacaa ttaggtctgt tccagtggga agagcgttgg 7200
ctattccaaa ttatgaaaac cttagacgca attggctcga gttattttag aggttataca 7260
cacctcaacc ccaccagaaa tctggtcgtg aatgtgactg gtgggggtaa atttgttata 7320
accagaatag caaaaaaaaa aaaaaaaaaa aaaaaa 7356
<210> 13
<211> 7397
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 13
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gaatgaagtt ctacatggac aagtatggtc ttgatcttcc 6360
ttactccact tatgtcaagg acgagctacg ctcgattgat aaaattaaga aagggaagtc 6420
ccgtctgatc gaggctagta gtctaaatga ttcagtgtac ctcagaatgg ctttcggaca 6480
tttgtatgag gctttccacg caaatcctgg gacaataact ggatcagccg tggggtgtaa 6540
ccctgacaca ttctggagca agctgccaat tttgctccct ggttcactct ttgctttcga 6600
ctactcaggt tatgatgcca gccttagccc tgtctggttc agagcattag aattagttct 6660
cagggagata gggtatagtg aagaggcggt ctcactcatt gagggaatca accacacaca 6720
ccatgtgtat cgtaataaga cctattgtgt gcttggtggg atgccctcag gttgttcggg 6780
aacatccatt ttcaactcaa tgatcaacaa cattatcatc agagcactgc tcataaaaac 6840
atttaagggc attgacttgg atgaactcaa catggtcgct tatggagacg atgtgctcgc 6900
tagctatccc ttcccaattg attgcttgga actagcaaag actggtaagg agtatggttt 6960
gaccatgact cctgctgata aatctccttg cttcaatgag gttaattggg gtaatgcgac 7020
cttccttaaa aggggctttt tgcccgatga acagtttccg ttcttgattc accccactat 7080
gccaatgagg gagatccatg agtccattcg atggaccaag gacgcccgaa acactcaaga 7140
tcatgtgcgg tccttgtgcc tcctagcatg gcataatggt aaacaagaat atgagaagtt 7200
tgtgagcaca attaggtctg ttccagtggg aagagcgttg gctattccaa attatgaaaa 7260
ccttagacgc aattggctcg agttatttta gaggttatac acacctcaac cccaccagaa 7320
atctggtcgt gaatgtgact ggtgggggta aatttgttat aaccagaata gcaaaaaaaa 7380
aaaaaaaaaa aaaaaaa 7397
<210> 14
<211> 7395
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 14
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gagaagttct acatggacaa gtatggtctt gatcttcctt 6360
actccactta tgtcaaggac gagctacgct cgattgataa aattaagaaa gggaagtccc 6420
gtctgatcga ggctagtagt ctaaatgatt cagtgtacct cagaatggct ttcggacatt 6480
tgtatgaggc tttccacgca aatcctggga caataactgg atcagccgtg gggtgtaacc 6540
ctgacacatt ctggagcaag ctgccaattt tgctccctgg ttcactcttt gctttcgact 6600
actcaggtta tgatgccagc cttagccctg tctggttcag agcattagaa ttagttctca 6660
gggagatagg gtatagtgaa gaggcggtct cactcattga gggaatcaac cacacacacc 6720
atgtgtatcg taataagacc tattgtgtgc ttggtgggat gccctcaggt tgttcgggaa 6780
catccatttt caactcaatg atcaacaaca ttatcatcag agcactgctc ataaaaacat 6840
ttaagggcat tgacttggat gaactcaaca tggtcgctta tggagacgat gtgctcgcta 6900
gctatccctt cccaattgat tgcttggaac tagcaaagac tggtaaggag tatggtttga 6960
ccatgactcc tgctgataaa tctccttgct tcaatgaggt taattggggt aatgcgacct 7020
tccttaaaag gggctttttg cccgatgaac agtttccgtt cttgattcac cccactatgc 7080
caatgaggga gatccatgag tccattcgat ggaccaagga cgcccgaaac actcaagatc 7140
atgtgcggtc cttgtgcctc ctagcatggc ataatggtaa acaagaatat gagaagtttg 7200
tgagcacaat taggtctgtt ccagtgggaa gagcgttggc tattccaaat tatgaaaacc 7260
ttagacgcaa ttggctcgag ttattttaga ggttatacac acctcaaccc caccagaaat 7320
ctggtcgtga atgtgactgg tgggggtaaa tttgttataa ccagaatagc aaaaaaaaaa 7380
aaaaaaaaaa aaaaa 7395
<210> 15
<211> 7380
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 15
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcatg tgtgcttggt gggatgccct caggttgttc gggaacatcc attttcaact 6780
caatgatcaa caacattatc atcagagcac tgctcataaa aacatttaag ggcattgact 6840
tggatgaact caacatggtc gcttatggag acgatgtgct cgctagctat cccttcccaa 6900
ttgattgctt ggaactagca aagactggta aggagtatgg tttgaccatg actcctgctg 6960
ataaatctcc ttgcttcaat gaggttaatt ggggtaatgc gaccttcctt aaaaggggct 7020
ttttgcccga tgaacagttt ccgttcttga ttcaccccac tatgccaatg agggagatcc 7080
atgagtccat tcgatggacc aaggacgccc gaaacactca agatcatgtg cggtccttgt 7140
gcctcctagc atggcataat ggtaaacaag aatatgagaa gtttgtgagc acaattaggt 7200
ctgttccagt gggaagagcg ttggctattc caaattatga aaaccttaga cgcaattggc 7260
tcgagttatt ttagaggtta tacacacctc aaccccacca gaaatctggt cgtgaatgtg 7320
actggtgggg gtaaatttgt tataaccaga atagcaaaaa aaaaaaaaaa aaaaaaaaaa 7380
<210> 16
<211> 7385
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 16
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactaaa tctccttgct tcaatgaggt taattggggt aatgcgacct tccttaaaag 7020
gggctttttg cccgatgaac agtttccgtt cttgattcac cccactatgc caatgaggga 7080
gatccatgag tccattcgat ggaccaagga cgcccgaaac actcaagatc atgtgcggtc 7140
cttgtgcctc ctagcatggc ataatggtaa acaagaatat gagaagtttg tgagcacaat 7200
taggtctgtt ccagtgggaa gagcgttggc tattccaaat tatgaaaacc ttagacgcaa 7260
ttggctcgag ttattttaga ggttatacac acctcaaccc caccagaaat ctggtcgtga 7320
atgtgactgg tgggggtaaa tttgttataa ccagaatagc aaaaaaaaaa aaaaaaaaaa 7380
aaaaa 7385
<210> 17
<211> 7383
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 17
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaacaatc tccttgcttc aatgaggtta attggggtaa tgcgaccttc cttaaaaggg 7020
gctttttgcc cgatgaacag tttccgttct tgattcaccc cactatgcca atgagggaga 7080
tccatgagtc cattcgatgg accaaggacg cccgaaacac tcaagatcat gtgcggtcct 7140
tgtgcctcct agcatggcat aatggtaaac aagaatatga gaagtttgtg agcacaatta 7200
ggtctgttcc agtgggaaga gcgttggcta ttccaaatta tgaaaacctt agacgcaatt 7260
ggctcgagtt attttagagg ttatacacac ctcaacccca ccagaaatct ggtcgtgaat 7320
gtgactggtg ggggtaaatt tgttataacc agaatagcaa aaaaaaaaaa aaaaaaaaaa 7380
aaa 7383
<210> 18
<211> 7407
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 18
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct gataaatctc 7020
cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc tttttgcccg 7080
atgaacagtt tccgttctgg gagatccatg agtccattcg atggaccaag gacgcccgaa 7140
acactcaaga tcatgtgcgg tccttgtgcc tcctagcatg gcataatggt aaacaagaat 7200
atgagaagtt tgtgagcaca attaggtctg ttccagtggg aagagcgttg gctattccaa 7260
attatgaaaa ccttagacgc aattggctcg agttatttta gaggttatac acacctcaac 7320
cccaccagaa atctggtcgt gaatgtgact ggtgggggta aatttgttat aaccagaata 7380
gcaaaaaaaa aaaaaaaaaa aaaaaaa 7407
<210> 19
<211> 7396
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 19
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct gataaatctc 7020
cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc tttttgcccg 7080
atgaacagtt tccgttcttg attcacccca ctatgccaat gagggagatc catgagtcca 7140
ttcgatggac caaggacgcc cgaaacatgg cataatggta aacaagaata tgagaagttt 7200
gtgagcacaa ttaggtctgt tccagtggga agagcgttgg ctattccaaa ttatgaaaac 7260
cttagacgca attggctcga gttattttag aggttataca cacctcaacc ccaccagaaa 7320
tctggtcgtg aatgtgactg gtgggggtaa atttgttata accagaatag caaaaaaaaa 7380
aaaaaaaaaa aaaaaa 7396
<210> 20
<211> 7395
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 20
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct gataaatctc 7020
cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc tttttgcccg 7080
atgaacagtt tccgttcttg attcacccca ctatgccaat gagggagatc catgagtcca 7140
ttcgatggac caaggacgcc cgaaaatggc ataatggtaa acaagaatat gagaagtttg 7200
tgagcacaat taggtctgtt ccagtgggaa gagcgttggc tattccaaat tatgaaaacc 7260
ttagacgcaa ttggctcgag ttattttaga ggttatacac acctcaaccc caccagaaat 7320
ctggtcgtga atgtgactgg tgggggtaaa tttgttataa ccagaatagc aaaaaaaaaa 7380
aaaaaaaaaa aaaaa 7395
<210> 21
<211> 7377
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 21
ttaaaacagc ctgtgggttg cacccaccca cagggcccac tgggcgcaag cactctggta 60
ccccggtacc tttgtgtgcc tgttttatac cccccccccc aatgaaactt agaagcagca 120
aaccacgatc aatagtaggc ataacgctcc agttatgtct tgatcaagca cttctgtttc 180
cccggactga gtatcaatag actgctcgcg cggttgaagg agaaaacgtt cgttatccgg 240
ctagctactt cggaaaacct agtaacacca tgaaagttgc ggagagcttc gttcagcact 300
cccccagtgt agatcaggtc gatgagtcac cgcattcccc acgggcgacc gtggcggtgg 360
ctgcgttggc ggcctgccca tggggtaacc catggggcgc tctaatacgg acatggtgtg 420
aagagtctac tgagctagtt agtagtcctc cggcccctga atgcggctaa tcccaactgc 480
ggagcacacg cccacaagcc agcgggtagt gtgtcgtaac gggtaactct gcagcggaac 540
cgactacttt gggtgtccgt gtttcctttt atctttatat tggctgctta tggtgacaat 600
taaagaattg ttaccatata gctattggat tggccatccg gtgtgcaaca gagcaattat 660
ttaccaattt gttggttttg taccattaac cttgaattct gtgaccaccc ttaattatat 720
tttgaccctt aacgcagcta aacatgggtt cgcaagtgtc tacacagcgc tccggttctc 780
atgaaaactc aaactcagcc actgagggtt ctaccataaa ctacaccacc atcaattact 840
acaaagactc ttatgctgcc acagcaggca aacagagtct caagcaggat ccagacaagt 900
ttgcaaatcc tgttaaagac atcttcactg aaatggcagc gccattgaag tccccatccg 960
ctgaggcatg tggatacagt gatcgagtgg cacaattaac tattggcaac tccaccatca 1020
ccacgcaaga agcggctaac atcatagtcg gttatggtga gtggccttct tactgctcag 1080
attctgacgc tacagcagtg gataaaccaa cgcgcccgga tgtttcagtg aataggtttt 1140
acacgttaga cactaaatta tgggagaaat cgtccaaggg atggtactgg aagttcccgg 1200
atgtgttaac tgaaactggg gtttttgggc aaaatgcaca attccactac ctctaccgat 1260
cagggttctg catccacgtg cagtgtaatg ctagtaaatt ccaccaagga gcactcctag 1320
tcgctgtcct accagagtat gtcattggga cagtagcagg cggcacaggg acggaagata 1380
cccacccccc ttataagcag acccaacccg gtgccgatgg cttcgagctg cagcacccgt 1440
acgtgcttga cgctggcatc ccaatatcac agttaacagt gtgcccacac cagtggatta 1500
atttgaggac caacaattgt gctacaataa tagtgccata cattaacgca ctgccttttg 1560
attctgcctt gaaccattgc aactttggcc tgctagttgt gcctattagt ccactagact 1620
acgaccaagg agcgacgcca gtaatcccta taactatcac attggcccca atgtgttctg 1680
agttcgcagg tcttaggcag gcagtcacgc aagggttccc taccgagcta aaacctggca 1740
caaatcaatt cttaaccacc gatgatggtg tctcagcacc tattctacca aacttccacc 1800
ccaccccgtg tatccacata cctggtgaag tgaggaattt gctagagtta tgccaggtgg 1860
aaaccattct ggaggttaat aatgtgccca cgaatgccac tagcttgatg gagagactgc 1920
gcttcccggt ctcagcacaa gcagggaaag gtgaactgtg tgcggtgttt agagccgatc 1980
ctgggcgaaa cggaccatgg caatccacct tactgggtca gttgtgcggg tactacaccc 2040
aatggtcagg atcattggag gtcaccttca tgtttactgg atccttcatg gctaccggca 2100
agatgctcat agcctataca ccgccaggag gtcctctgcc caaggaccgg gcgaccgcca 2160
tgttgggcac gcacgtcatc tgggattttg ggctgcaatc gtctgttacc cttgtaatac 2220
catggatcag caacactcat tatagagcac atgcccgaga tggagtgttt gactactaca 2280
ccacagggtt ggtcagtata tggtatcaga caaattacgt ggttccaatt ggtgcgccca 2340
acacagccta tataatagca ctagcggcag cccaaaagaa cttcactatg aaattgtgca 2400
aggatgctag tgatatcttg cagacgggca ccatccaggg agatagggtg gcagatgtaa 2460
ttgaaagctc cataggagat agcgtgagca gagccctcac tcacgctcta ccagcaccca 2520
caggtcagaa cacacaggtg agcagtcatc gactggatac gggcaaggtt ccagcactcc 2580
aagctgctga aattggagca tcatcaaatg ctagtgacga gagtatgatt gagacacgct 2640
gtgtcctcaa ctcgcacagt acagcagaga ccactcttga tagtttcttc agcagggcgg 2700
gattagttgg agagatagat ctccctcttg agggcacaac taacccaaat ggttatgcca 2760
actgggacat agatataaca ggttacgcgc aaatgcgtag aaaggtagag ctcttcacct 2820
acatgcgctt tgatgcagag ttcacttttg ttgcgtgtac acctaccggg gaagttgttc 2880
cacaactgct ccaatatatg tttgtgccac ctggagcccc aaagccagat tctagggaat 2940
cccttgcatg gcaaaccgcc actaacccct cagtttttgt caagctgtca gaccctccag 3000
cacaggtttc agtgccattc atgtcacctg cgagtgctta tcaatggttt tatgacggat 3060
atcccacgtt cggagaacac aaacaggaga aagatcttga atatggggca tgtcctaata 3120
acatgatggg cacgttctca gtgcggactg tagggtcctc caagtccaag taccctctag 3180
tgattaggat ttacatgaga atgaagcacg tcagggcgtg gatacctcgc ccgatgcgta 3240
accagaacta cctattcaaa gccaatccaa attatgctgg caactccgtt aagccaactg 3300
gtgccagtcg cacagcgatc accactcttg ggaaatttgg acaacagtct ggggctattt 3360
atgtgggcaa ctttagggtg gtcaaccgac atcttgccac tcacaatgat tgggcaaatc 3420
ttgtttggga agacagctct cgcgacttgc tcgtgtcatc cactaccgcc caaggttgcg 3480
acacgattgc ccgctgcgat tgccagacag gggtgtacta ctgtaactcg atgagaaaac 3540
actacccagt tagtttttca aaacccagcc tgatctatgt agaggctagc gagtattacc 3600
cagccaggta ccaatcacat ctcatgctcg cacagggtca ctcagaacct ggtgattgcg 3660
gtggtatcct taggtgccaa catggcgtcg tcggcatagt gtccactggt ggtaatgggc 3720
ttgttggctt tgcagacgtc agagacctct tgtggttaga tgaagaagcc atggaacagg 3780
gcgtgtccga ctacatcaag ggtctcgggg atgcttttgg aacaggcttt actgacgcag 3840
tctcaaggga ggttgaagct ctcaagaact atctcatagg gtctgaagga gcagttgaga 3900
aaattttgaa aaatctaatt aaactaatct ctgcactggt gattgtgatc agaagtgatt 3960
atgatatggt taccctcact gcgaccttgg cgctgatagg ttgtcatggc agtccgtggg 4020
cttggatcaa agccaaaaca gcctccatct taggtatccc tattgctcaa aagcagagcg 4080
cttcctggct caagaagttc aatgatatgg ccaacgccgc taaggggtta gagtgggttt 4140
ccaacaagat cagcaaattt attgattggc ttaaggagaa gatagtacca gcagctaggg 4200
agaaggttga attcctaaat aacttgaaac agctgccact gctagagaat cagatctcaa 4260
acttggaaca atctgctgcc tcacaagagg accttgaaat catgtttggg aatgtatcgt 4320
acctagctca cttctgccgc aagttccaac cgctatacgc cacggaagct aggagagtct 4380
atgccctgga gaagaggatg aataactata tgcagttcaa gagcaaacac cgaattgaac 4440
ctgtatgtct catcattagg ggctcaccag gcactgggaa gtctctagcc actggtatta 4500
ttgctcgagc aatcgctgat aagtaccact ccagcgtgta ctcgctccca ccagacccag 4560
atcattttga cggttacaag caacaggtgg ttaccgtgat ggatgatctg tgccaaaacc 4620
ccgacggaaa ggatatgtct ttattctgtc aaatggtatc caccgtagac ttcattccac 4680
caatggcttc cctcgaggag aagggagttt ccttcacctc taagtttgtc atcgcatcca 4740
ctaatgccag taatatcata gtaccaacag tgtctgattc cgacgctatt cgccgcaggt 4800
tctacatgga ctgtgacatt gaagtgacag actcatacaa aacagatcta ggtagactgg 4860
atgcagggcg agccgctaaa ctgtgctctg agaacaacac tgcaaatttc aaacgttgta 4920
gcccgttagt gtgcgggaaa gctatccaac ttagagatag aaagtctaaa gtcagataca 4980
gtgtggatac ggtggtttca gaacttatta gggaatacag caataggtcc gctattggca 5040
acacaatcga ggctcttttc caaggtccac ccaagttcag gccaattagg attagccttg 5100
aagaaaaacc agccccagac gctattagcg atctccttgc tagcgtagat agtgaagaag 5160
tgcgccagta ctgcagggat caaggctgga ttattcctga agttcccacc aatgtagagc 5220
ggcaccttaa tagagcggtg cttgtcatgc aatccatcgc cacagtagtg gcagttgtct 5280
cgttggtgta tgtcatctac aagctctttg cagggttcca gggtgcgtat tctggtgctc 5340
ctaagcaagt gcttaagaaa cctgcccttc gcacagcaac agtacagggc ccgagccttg 5400
actttgctct ctccctactg agaaggaaca tcagacaagt tcaaacagac caggggcatt 5460
tcaccatgtt gggtgttagg gatcgcttag cagtccttcc acgtcactca caacctggca 5520
aaactatttg ggttgaacac aaactcgtga acgtccttga tgcagttgaa ctggtggatg 5580
agcaaggagt caacctggaa ttgaccctca ttactcttga caccaacgag aagtttaggg 5640
atattaccaa gttcatcccg gaaaatatta gcactgctag tgatgccacc ctagtgatca 5700
acacggagca tatgccatca atgtttgtcc cggtgggtga cgttgtgcag tatggctttt 5760
tgaatctcag tggtaagcct acccatcgca ccatgatgta caactttcct actaaagcag 5820
ggcagtgtgg aggagtagtg acatctgttg ggaaggttgt cggtattcac attggtggca 5880
atggcagaca gggtttttgc gcaggcctca aaaggagtta ctttgctagt gaacaaggag 5940
agatccaatg ggttaagccc aacaaagaaa ctggaagact caacattaat ggaccaaccc 6000
gcaccaaatt agaacctagt gtattccatg acatcttcga gggaaataaa gagccagctg 6060
tcttgcacag taaagacccc cgacttgaag tagattttga acaggccctg ttctctaagt 6120
atgtgggaaa cacactacat gagcctgacg agtacatcaa agaggcggct cttcattacg 6180
cgaaccaatt gaagcaatta gaaattaata cctctcaaat gagcatggaa gaggcctgct 6240
acggtactga gaatcttgag gctattgatc ttcacactag tgcaggatac ccttatagtg 6300
ccttggggat aaagaaaaga gacatcttag accctaccac cagggacgtg agtaaaatga 6360
agttctacat ggacaagtat ggtcttgatc ttccttactc cacttatgtc aaggacgagc 6420
tacgctcgat tgataaaatt aagaaaggga agtcccgtct gatcgaggct agtagtctaa 6480
atgattcagt gtacctcaga atggctttcg gacatttgta tgaggctttc cacgcaaatc 6540
ctgggacaat aactggatca gccgtggggt gtaaccctga cacattctgg agcaagctgc 6600
caattttgct ccctggttca ctctttgctt tcgactactc aggttatgat gccagcctta 6660
gccctgtctg gttcagagca ttagaattag ttctcaggga gatagggtat agtgaagagg 6720
cggtctcact cattgaggga atcaaccaca cacaccatgt gtatcgtaat aagacctatt 6780
gtgtgcttgg tgggatgccc tcaggttgtt cgggaacatc cattttcaac tcaatgatca 6840
acaacattat catcagagca ctgctcataa aaacatttaa gggcattgac ttggatgaac 6900
tcaacatggt cgcttatgga gacgatgtgc tcgctagcta tcccttccca attgattgct 6960
tggaactagc aaagactggt aaggagtatg gtttgaccat gactcctgct gataaatctc 7020
cttgcttcaa tgaggttaat tggggtaatg cgaccttcct taaaaggggc tttttgcccg 7080
atgaacagtt tccgttcttg attcacccca ctatgccaat gagggagatc catgagtcca 7140
ttcgatggac caaggacgcc cgaaacactc aagatcatgt gcggtccttg tgcctcctag 7200
catggcataa tggtaaacaa gaatatgaga agtttgtgaa ccttagacgc aattggctcg 7260
agttatttta gaggttatac acacctcaac cccaccagaa atctggtcgt gaatgtgact 7320
ggtgggggta aatttgttat aaccagaata gcaaaaaaaa aaaaaaaaaa aaaaaaa 7377
<210> 22
<211> 927
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 22
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtccaa aaaaccccac gcgcttggaa gcgcaggatg ggaaaagaag gtggcgacct 720
tccccaccct tcaatctggg gcctgaactg gagactagct gtgaatctcc agcagaggga 780
ctagtggtta gaggagaccc cccggaaaac gcaaaacagc atattgacgc tgggaaagac 840
cagagactcc atgagtttcc accacgctgg ccgccaggca cagatcgccg aacttcggcg 900
gccggtgtgg ggaaatccat ggtttct 927
<210> 23
<211> 1170
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 23
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagctgc ctgtcttgca 300
aaatcatatg cgcagatgtg gcagctcctt tatttccaca gaagagacct tcgactgatg 360
gctaatgcca tttgctcggc tgtgccagtt gactgggtac caactgggag aaccacctgg 420
tcaatccatg gaaagggaga atggatgacc actgaggaca tgctcatggt gtggaataga 480
gtgtggattg aggagaacga ccatatggag gacaagactc ctgtaacaaa atggacagac 540
attccctatc taggaaaaag ggaggactta tggtgtggat cccttatagg gcacagaccc 600
cgcaccactt gggctgaaaa catcaaagac acagtcaaca tggtgcgcag gatcataggt 660
gatgaagaaa agtacatgga ctatctatcc acccaagtcc gctacttggg tgaggaaggg 720
tccacacccg gagtgttgta agcaccaatt ttagtgttgt caggcctgct agtcagccac 780
agtttgggga aagctgtgca gcctgtaacc cccccaggag aagctgggaa accaagctca 840
tagtcaggcc gagaacgcca tggcacggaa gaagccatgc tgcctgtgag cccctcagag 900
gacactgagt caaaaaaccc cacgcgcttg gaagcgcagg atgggaaaag aaggtggcga 960
ccttccccac ccttcaatct ggggcctgaa ctggagacta gctgtgaatc tccagcagag 1020
ggactagtgg ttagaggaga ccccccggaa aacgcaaaac agcatattga cgctgggaaa 1080
gaccagagac tccatgagtt tccaccacgc tggccgccag gcacagatcg ccgaacttcg 1140
gcggccggtg tggggaaatc catggtttct 1170
<210> 24
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 24
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgaaaagta catggactat ctatccaccc aagtccgcta cttgggtgag 840
gaagggtcca cacccggagt gttgtaagca ccaattttag tgttgtcagg cctgctagtc 900
agccacagtt tggggaaagc tgtgcagcct gtaacccccc caggagaagc tgggaaacca 960
agctcatagt caggccgaga acgccatggc acggaagaag ccatgctgcc tgtgagcccc 1020
tcagaggaca ctgagtcaaa aaaccccacg cgcttggaag cgcaggatgg gaaaagaagg 1080
tggcgacctt ccccaccctt caatctgggg cctgaactgg agactagctg tgaatctcca 1140
gcagagggac tagtggttag aggagacccc ccggaaaacg caaaacagca tattgacgct 1200
gggaaagacc agagactcca tgagtttcca ccacgctggc cgccaggcac agatcgccga 1260
acttcggcgg ccggtgtggg gaaatccatg gtttct 1296
<210> 25
<211> 1731
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 25
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg agtgtggatt gaggagaacg accatatgga ggacaagact 1080
cctgtaacaa aatggacaga cattccctat ctaggaaaaa gggaggactt atggtgtgga 1140
tcccttatag ggcacagacc ccgcaccact tgggctgaaa acatcaaaga cacagtcaac 1200
atggtgcgca ggatcatagg tgatgaagaa aagtacatgg actatctatc cacccaagtc 1260
cgctacttgg gtgaggaagg gtccacaccc ggagtgttgt aagcaccaat tttagtgttg 1320
tcaggcctgc tagtcagcca cagtttgggg aaagctgtgc agcctgtaac ccccccagga 1380
gaagctggga aaccaagctc atagtcaggc cgagaacgcc atggcacgga agaagccatg 1440
ctgcctgtga gcccctcaga ggacactgag tcaaaaaacc ccacgcgctt ggaagcgcag 1500
gatgggaaaa gaaggtggcg accttcccca cccttcaatc tggggcctga actggagact 1560
agctgtgaat ctccagcaga gggactagtg gttagaggag accccccgga aaacgcaaaa 1620
cagcatattg acgctgggaa agaccagaga ctccatgagt ttccaccacg ctggccgcca 1680
ggcacagatc gccgaacttc ggcggccggt gtggggaaat ccatggtttc t 1731
<210> 26
<211> 1873
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 26
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1080
acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga 1140
ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1200
aacacaaggt gaggcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1260
attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1320
atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1380
ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttgtcaatga 1440
tacaggatat gaaactgtgt tgtcaggcct gctagtcagc cacagtttgg ggaaagctgt 1500
gcagcctgta acccccccag gagaagctgg gaaaccaagc tcatagtcag gccgagaacg 1560
ccatggcacg gaagaagcca tgctgcctgt gagcccctca gaggacactg agtcaaaaaa 1620
ccccacgcgc ttggaagcgc aggatgggaa aagaaggtgg cgaccttccc cacccttcaa 1680
tctggggcct gaactggaga ctagctgtga atctccagca gagggactag tggttagagg 1740
agaccccccg gaaaacgcaa aacagcatat tgacgctggg aaagaccaga gactccatga 1800
gtttccacca cgctggccgc caggcacaga tcgccgaact tcggcggccg gtgtggggaa 1860
atccatggtt tct 1873
<210> 27
<211> 4862
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 27
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1080
acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga 1140
ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1200
aacacaaggt gaggcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1260
attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1320
atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1380
ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttgtcaatga 1440
tacaggatat gaaactgacg aaaatagagc gaaagtcgag gttacgccta attcaccaag 1500
agcggaagca accttgggag gctttggaag cttaggactt gactgtgaac caaggacagg 1560
ccttgacttt tcagatctgt attacctgac catgaacaat aagcattggt tggtgcacaa 1620
agagtggttt catgacatcc cattgccttg gcatgctggg gcagacaccg gaactccaca 1680
ctggaacaac aaagaggcat tggtagaatt caaggatgcc cacgccaaga ggcaaaccgt 1740
cgtcgttctg gggagccagg aaggagccgt tcacacggct ctcgctggag ctctagaggc 1800
tgagatggat ggtgcaaagg gaaagctgtt ctctggccac ttgaaatgcc gcctaaaaat 1860
ggacaagctt agattgaagg gcgtgtcata ttccttgtgc actgcggcat tcacattcac 1920
caaggtccca gctgaaacac tgcatggaac agtcacagtg gaggtgcagt atgcagggac 1980
agatggaccc tgcaagatcc cagtccagat ggcggtggac atgcagaccc tgaccccagt 2040
tggaaggctg ataaccgcca accccgtgat tactgaaagc actgagaact caaagatgat 2100
gttggagctt gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa 2160
aatcacccac cactggcata ggagtggtag caccatcgga aaggcatttg aggccactgt 2220
gagaggcgcc aagagaatgg cagtcctggg ggatacagcc tgggacttcg gatcagtcgg 2280
gggtgtgttc aactcactgg gtaagggcat tcaccagatt tttggagcag ccttcaaatc 2340
actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tagtgtggtt 2400
aggtttgaac acaaagaatg gatctatctc cctcacatgc ttggccctgg ggggagtgat 2460
gatcttcctc tccacggctg tttctgctga tgtggggtgc tcagtggact tctcaaaaaa 2520
ggaaacgaga tgtggcacgg gggtattcat ctataatgat gttgaagcct ggagggaccg 2580
gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcctggga 2640
agaggggatc tgtgggatct catccgtttc aagaatggaa aacatcatgt ggaaatcagt 2700
agaaggggag ctcaatgcta tcctagagga gaatggagtt caactgacag ttgttgtggg 2760
atctgtaaaa aaccccatgt ggagaggtcc acaaagattg ccagtgcctg tgaatgagct 2820
gccccatggc tggaaagcct gggggaaatc gtattttgtt agggcggcaa agaccaacaa 2880
cagttttgtt gtcgacggtg acacactgaa ggaatgtccg cttgagcaca gagcatggaa 2940
tagttttctt gtggaggatc acgggtttgg agtcttccac accagtgtct ggcttaaggt 3000
cagagaagat tactcattag aatgtgaccc agccgtcata ggaacagctg ttaagggaag 3060
ggaggccgcg cacagtgatc tgggctattg gaaaaagaga aaagaagcaa ggagagttcg 3120
ggaaagcaaa aggtagccgc gccatctggt acatgtggtt gggagccaga ttcttggagt 3180
ttgaagccct tggattcttg aacgaggacc attggatggg aagagaaaac tcaggaggtg 3240
gagtcgaagg gttaggattg caaagacttg gatacattct agaagaaatg aatcgggcac 3300
caggaggaaa gatgtacgca gatgacactg ctggctggga cacccgcatt agtaagtttg 3360
atctggagaa tgaagctctg attaccaacc aaatggagga agggcacaga actctggcgt 3420
tggccgtgat taaatacaca taccaaaaca aagtggtgaa ggttctcaga ccagctgaag 3480
gaggaaaaac agttatggac atcatttcaa gacaagacca gagagggagt ggacaagttg 3540
tcacttatgc tctcaacaca ttcaccaact tggtggtgca gcttatccgg aacatggaag 3600
ctgaggaagt gttagagatg caagacttat ggttgttgag gaagccagag aaagtgacca 3660
gatggttgca gagcaatgga tgggatagac tcaaacgaat ggcggtcagt ggagatgact 3720
gcgttgtgaa gccaatcgat gataggtttg cacatgccct caggttcttg aatgacatgg 3780
gaaaagttag gaaagacaca caggagtgga aaccctcgac tggatggagc aattgggaag 3840
aagtcccgtt ctgctcccac cacttcaaca agctgtacct caaggatggg agatccattg 3900
tggtcccttg ccgccaccaa gatgaactga ttggccgagc tcgcgtctca ccaggggcag 3960
gatggagcat ccgggagact gcctgtcttg caaaatcata tgcgcagatg tggcagctcc 4020
tttatttcca cagaagagac cttcgactga tggctaatgc catttgctcg gctgtgccag 4080
ttgactgggt accaactggg agaaccacct ggtcaatcca tggaaaggga gaatggatga 4140
ccactgagga catgctcatg gtgtggaata gagtgtggat tgaggagaac gaccatatgg 4200
aggacaagac tcctgtaaca aaatggacag acattcccta tctaggaaaa agggaggact 4260
tatggtgtgg atcccttata gggcacagac cccgcaccac ttgggctgaa aacatcaaag 4320
acacagtcaa catggtgcgc aggatcatag gtgatgaaga aaagtacatg gactatctat 4380
ccacccaagt ccgctacttg ggtgaggaag ggtccacacc cggagtgttg taagcaccaa 4440
ttttagtgtt gtcaggcctg ctagtcagcc acagtttggg gaaagctgtg cagcctgtaa 4500
cccccccagg agaagctggg aaaccaagct catagtcagg ccgagaacgc catggcacgg 4560
aagaagccat gctgcctgtg agcccctcag aggacactga gtcaaaaaac cccacgcgct 4620
tggaagcgca ggatgggaaa agaaggtggc gaccttcccc acccttcaat ctggggcctg 4680
aactggagac tagctgtgaa tctccagcag agggactagt ggttagagga gaccccccgg 4740
aaaacgcaaa acagcatatt gacgctggga aagaccagag actccatgag tttccaccac 4800
gctggccgcc aggcacagat cgccgaactt cggcggccgg tgtggggaaa tccatggttt 4860
ct 4862
<210> 28
<211> 6513
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 28
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagtgaag 360
aaaggagaga ccacagatgg agtgtacaga gtgatgactc gcagactgct aggttcaaca 420
caggttggag tgggagtcat gcaagaggga gtcttccaca ccatgtggca cgttacaaaa 480
ggagccgcac tgaggagcgg tgagggaaga cttgatccat actgggggga tgtcaagcag 540
gacttggtgt catactgtgg gccttggaag ttggatgcag cttgggatgg actcagcgag 600
gtacagcttt tggccgtacc tcccggagag agggccagaa acattcagac cctgcctgga 660
atattcaaga caaaggacgg ggacatcgga gcagttgctc tggactaccc tgcagggacc 720
tcaggatctc cgatcctaga caaatgtgga agagtgatag gactctatgg caatggggtt 780
gtgatcaaga atggaagcta tgttagtgct ataacccagg gaaagaggga ggaggagact 840
ccggttgaat gtttcgaacc ctcgatgctg aagaagaagc agctaactgt cttggatctg 900
catccaggag ccggaaaaac caggagagtt cttcctgaaa tagtccgtga agccataaaa 960
aagagactcc ggacagtgat cttggcacca actagggttg tcgctgctga gatggaggag 1020
gccttgagag gacttccggt gcgttacatg acaacagcag tcaacgtcac ccattctggg 1080
acagaaatcg ttgatttgat gtgccatgcc actttcactt cacgcttact acaacccatc 1140
agagtcccta attacaatct ctacatcatg gatgaagccc acttcacaga cccctcaagt 1200
atagctgcaa gaggatacat atcaacaagg gttgaaatgg gcgaggcggc tgccattttt 1260
atgactgcca caccaccagg aacccgtgat gcgtttcctg actctaactc accaatcatg 1320
gacacagaag tggaagtccc agagagagcc tggagctcag gctttgattg ggtgacagac 1380
cattctggga aaacagtttg gttcgttcca agcgtgagaa acggaaatga aatcgcagcc 1440
tgtctgacaa aggctggaaa gcgggtcata cagctcagca ggaagacttt tgagacagaa 1500
tttcagaaaa caaaaaatca agagtgggac tttgtcataa caactgacat ctcagagatg 1560
ggcgccaact tcaaggctga ccgggtcata gactctagga gatgcctaaa accagtcata 1620
cttgatggtg agagagtcat cttggctggg cccatgcctg tcacgcatgc tagtgctgct 1680
cagaggagag gacgtatagg caggaaccct aacaaacctg gagatgagta catgtatgga 1740
ggtgggtgtg cagagactga tgaaggccat gcacactggc ttgaagcaag aatgcttctt 1800
gacaacatct acctccagga tggcctcata gcctcgctct atcggcctga ggccgataag 1860
gtagccgcca ttgagggaga gtttaagctg aggacagagc aaaggaagac cttcgtggaa 1920
ctcatgaaga gaggagacct tcccgtctgg ctagcctatc aggttgcatc tgccggaata 1980
acttacacag acagaagatg gtgctttgat ggcacaacca acaacaccat aatggaagac 2040
agcgtaccag cagaggtgtg gacaaagtat ggagagaaga gagtgctcaa accgagatgg 2100
atggatgcta gggtctgttc agaccatgcg gccctgaagt cgttcaaaga attcgccgct 2160
ggaaaaagag gagcggcttt gggagtaatg gaggccctgg gaacactgcc aggacacatg 2220
acagagaggt ttcaggaagc cattgacaac ctcgccgtgc tcatgcgagc agagactgga 2280
agcaggcctt ataaggcagc ggcagcccaa ctgccggaga ccctagagac cattatgctc 2340
ttaggtttgc tgggaacagt ttcactgggg atcttcttcg tcttgatgcg gaataagggc 2400
atcgggaaga tgggctttgg aatggtaacc cttggggcca gtgcatggct catgtggctt 2460
tcggaaattg aaccagccag aattgcatgt gtcctcattg ttgtgttttt attactggtg 2520
gtgctcatac ccgagccaga gaagcaaaga tctccccaag ataaccagat ggcaattatc 2580
atcatggtgg cagtgggcct tctaggtttg ataactgcaa acgaacttgg atggctggaa 2640
agaacaaaaa atgacatagc tcatctaatg ggaaggagag aagaaggagc aaccatggga 2700
ttctcaatgg acattgatct gcggccagcc tccgcctggg ctatctatgc cgcattgaca 2760
actctcatca ccccagctgt ccaacatgcg gtaaccactt catacaacaa ctactcctta 2820
atggcgatgg ccacacaagc tggagtgctg tttggcatgg gcaaagggat gccattttat 2880
gcatgggacc ttggagtccc gctgctaatg atgggttgct attcacaatt aacacccctg 2940
actctgatag tagctatcat tctgcttgtg gcgcactaca tgtacttgat cccaggccta 3000
caagcggcag cagcgcgtgc tgcccagaaa aggacagcag ctggcatcat gaagaatccc 3060
gttgtggatg gaatagtggt aactgacatt gacacaatga caatagaccc ccaggtggag 3120
aagaagatgg gacaagtgtt actcatagca gtagccatct ccagtgctgt gctgctgcgg 3180
accgcctggg gatgggggga ggctggagct ctgatcacag cagcgacctc caccttgtgg 3240
gaaggctctc caaacaaata ctggaactcc tctacagcca cctcactgtg caacatcttc 3300
agaggaagct atctggcagg agcttccctt atctatacag tgacgagaaa cgctggcctg 3360
gttaagagac gtggaggtgg gacgggagag actctgggag agaagtggaa agctcgtctg 3420
aatcagatgt cggccctgga gttctactct tataaaaagt caggtatcac tgaagtgtgt 3480
agagaggagg ctcgccgtgc cctcaaggat ggagtggcca caggaggaca tgccgtatcc 3540
cggggaagtg caaagctcag atggttggtg gagagaggat atctgcagcc ctatgggaag 3600
gttgttgacc tcggatgtgg cagagggggc tggagctatt atgccgccac catccgcaaa 3660
gtgcaggagg tgagaggata cacaaaggga ggtcccggtc atgaagaacc catgctggtg 3720
caaagctatg ggtggaacat agttcgtctc aagagtggag tggacgtctt ccacatggcg 3780
gctgagccgt gtgacactct gctgtgtgac ataggtgagt catcatctag tcctgaagtg 3840
gaagagacac gaacactcag agtgctctct atggtggggg actggcttga aaaaagacca 3900
ggggccttct gtataaaggt gctgtgccca tacaccagca ctatgatgga aaccatggag 3960
cgactgcaac gtaggcatgg gggaggatta gtcagagtgc cattgtctcg caactccaca 4020
catgagatgt actgggtctc tggggcaaag agcaacatca taaaaagtgt gtccaccaca 4080
agtcagctcc tcctgggacg catggatggc cccaggaggc cagtgaaata tgaggaggat 4140
gtgaacctcg gctcgggtac acgagctgtg gcaagctgtg ctgaggctcc taacatgaaa 4200
atcatcggca ggcgcattga gagaatccgc aatgaacatg cagaaacatg gtttcttgat 4260
gaaaaccacc catacaggac atgggcctac catgggagct acgaagcccc cacgcaagga 4320
tcagcgtctt ccctcgtgaa cggggttgtt agactcctgt caaagccttg ggacgtggtg 4380
actggagtta caggaatagc catgactgac accacaccat acggccaaca aagagtcttc 4440
aaagaaaaag tggacaccag ggtgccagat ccccaagaag gcactcgcca ggtaatgaac 4500
atagtctctt cctggctgtg gaaggagctg gggaaacgca agcggccacg cgtctgcacc 4560
aaagaagagt ttatcaacaa ggtgcgcagc aatgcagcac tgggagcaat atttgaagag 4620
gaaaaagaat ggaagacggc tgtggaagct gtgaatgatc caaggttttg ggccctagtg 4680
gatagggaga gagaacacca cctgagagga gagtgtcaca gctgtgtgta caacatgatg 4740
ggaaaaagag aaaagaagca aggagagttc gggaaagcaa aaggtagccg cgccatctgg 4800
tacatgtggt tgggagccag attcttggag tttgaagccc ttggattctt gaacgaggac 4860
cattggatgg gaagagaaaa ctcaggaggt ggagtcgaag ggttaggatt gcaaagactt 4920
ggatacattc tagaagaaat gaatcgggca ccaggaggaa agatgtacgc agatgacact 4980
gctggctggg acacccgcat tagtaagttt gatctggaga atgaagctct gattaccaac 5040
caaatggagg aagggcacag aactctggcg ttggccgtga ttaaatacac ataccaaaac 5100
aaagtggtga aggttctcag accagctgaa ggaggaaaaa cagttatgga catcatttca 5160
agacaagacc agagagggag tggacaagtt gtcacttatg ctctcaacac attcaccaac 5220
ttggtggtgc agcttatccg gaacatggaa gctgaggaag tgttagagat gcaagactta 5280
tggttgttga ggaagccaga gaaagtgacc agatggttgc agagcaatgg atgggataga 5340
ctcaaacgaa tggcggtcag tggagatgac tgcgttgtga agccaatcga tgataggttt 5400
gcacatgccc tcaggttctt gaatgacatg ggaaaagtta ggaaagacac acaggagtgg 5460
aaaccctcga ctggatggag caattgggaa gaagtcccgt tctgctccca ccacttcaac 5520
aagctgtacc tcaaggatgg gagatccatt gtggtccctt gccgccacca agatgaactg 5580
attggccgag ctcgcgtctc accaggggca ggatggagca tccgggagac tgcctgtctt 5640
gcaaaatcat atgcgcagat gtggcagctc ctttatttcc acagaagaga ccttcgactg 5700
atggctaatg ccatttgctc ggctgtgcca gttgactggg taccaactgg gagaaccacc 5760
tggtcaatcc atggaaaggg agaatggatg accactgagg acatgctcat ggtgtggaat 5820
agagtgtgga ttgaggagaa cgaccatatg gaggacaaga ctcctgtaac aaaatggaca 5880
gacattccct atctaggaaa aagggaggac ttatggtgtg gatcccttat agggcacaga 5940
ccccgcacca cttgggctga aaacatcaaa gacacagtca acatggtgcg caggatcata 6000
ggtgatgaag aaaagtacat ggactatcta tccacccaag tccgctactt gggtgaggaa 6060
gggtccacac ccggagtgtt gtaagcacca attttagtgt tgtcaggcct gctagtcagc 6120
cacagtttgg ggaaagctgt gcagcctgta acccccccag gagaagctgg gaaaccaagc 6180
tcatagtcag gccgagaacg ccatggcacg gaagaagcca tgctgcctgt gagcccctca 6240
gaggacactg agtcaaaaaa ccccacgcgc ttggaagcgc aggatgggaa aagaaggtgg 6300
cgaccttccc cacccttcaa tctggggcct gaactggaga ctagctgtga atctccagca 6360
gagggactag tggttagagg agaccccccg gaaaacgcaa aacagcatat tgacgctggg 6420
aaagaccaga gactccatga gtttccacca cgctggccgc caggcacaga tcgccgaact 6480
tcggcggccg gtgtggggaa atccatggtt tct 6513
<210> 29
<211> 8136
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 29
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta acaccagaga gggttacaga 600
acccaagtga aagggccatg gcacagtgaa gagcttgaaa tccggtttga ggaatgtcca 660
ggcaccaagg tttacgtgga ggagacatgc ggaactagag gaccatctct gagatcaact 720
actgcaagtg gaagggtcat tgaggaatgg tgctgtaggg aatgcacaat gcccccacta 780
tcgtttcgag caaaagacgg ctgctggtat ggaatggaga taaggcccag gaaagaacca 840
gagagcaact tagtgaggtc aatggtgaca gcggggtcaa ccgatcatat ggaccacttc 900
tctcttggag tgcttgtgat tctactcatg gtgcaggagg ggttgaagaa gagaatgacc 960
acaaagatca tcatgagcac atcaatggca gtgctggtag tcatgatctt gggaggattt 1020
tcaatgagtg acctggccaa gcttgtgatc ctgatgggtg ctactttcgc agaaatgaac 1080
actggaggag atgtagctca cttggcattg gtagcggcat ttaaagtcag accagccttg 1140
ctggtctcct tcattttcag agccaattgg acaccccgtg agagcatgct gctagccctg 1200
gcttcgtgtc ttctgcaaac tgcgatctct gctcttgaag gtgacttgat ggtcctcatt 1260
aatggatttg ctttggcctg gttggcaatt cgagcaatgg ccgtgccacg cactgacaac 1320
atcgctctac caatcttggc tgctctaaca ccactagctc gaggcacact gctcgtggca 1380
tggagagcgg gcctggctac ttgtggaggg atcatgctcc tctccctgaa agggaaaggt 1440
agtgtgaaga agaacctgcc atttgtcatg gccctgggat tgacagctgt gagggtagta 1500
gaccctatta atgtggtagg actactgtta ctcacaagga gtgggaagcg gagctggccc 1560
cctagtgaag ttctcacagc cgttggcctg atatgtgcac tggccggagg gtttgccaag 1620
gcagacattg agatggctgg acccatggct gcagtaggct tgctaattgt cagctatgtg 1680
gtctcgggaa agagtgtgga catgtacatt gaaagagcag gtgacatcac atgggaaaag 1740
gacgcggaag tcactggaaa cagtcctcgg cttgacgtgg cactggatga gagtggtgat 1800
ttctccttgg tagaggaaga tggtccaccc atgagagaga tcatactcaa ggtggtcctg 1860
atggccatct gtggcatgaa cccaatagct ataccttttg ctgcaggagc gtggtatgtg 1920
tatgtgaaga ctgggaaaag gagtggcgcc ctctgggacg tgcctgctcc caaagaagtg 1980
aagaaaggag agaccacaga tggagtgtac agagtgatga ctcgcagact gctaggttca 2040
acacaggttg gagtgggagt catgcaagag ggagtcttcc acaccatgtg gcacgttaca 2100
aaaggagccg cactgaggag cggtgaggga agacttgatc catactgggg ggatgtcaag 2160
caggacttgg tgtcatactg tgggccttgg aagttggatg cagcttggga tggactcagc 2220
gaggtacagc ttttggccgt acctcccgga gagagggcca gaaacattca gaccctgcct 2280
ggaatattca agacaaagga cggggacatc ggagcagttg ctctggacta ccctgcaggg 2340
acctcaggat ctccgatcct agacaaatgt ggaagagtga taggactcta tggcaatggg 2400
gttgtgatca agaatggaag ctatgttagt gctataaccc agggaaagag ggaggaggag 2460
actccggttg aatgtttcga accctcgatg ctgaagaaga agcagctaac tgtcttggat 2520
ctgcatccag gagccggaaa aaccaggaga gttcttcctg aaatagtccg tgaagccata 2580
aaaaagagac tccggacagt gatcttggca ccaactaggg ttgtcgctgc tgagatggag 2640
gaggccttga gaggacttcc ggtgcgttac atgacaacag cagtcaacgt cacccattct 2700
gggacagaaa tcgttgattt gatgtgccat gccactttca cttcacgctt actacaaccc 2760
atcagagtcc ctaattacaa tctctacatc atggatgaag cccacttcac agacccctca 2820
agtatagctg caagaggata catatcaaca agggttgaaa tgggcgaggc ggctgccatt 2880
tttatgactg ccacaccacc aggaacccgt gatgcgtttc ctgactctaa ctcaccaatc 2940
atggacacag aagtggaagt cccagagaga gcctggagct caggctttga ttgggtgaca 3000
gaccattctg ggaaaacagt ttggttcgtt ccaagcgtga gaaacggaaa tgaaatcgca 3060
gcctgtctga caaaggctgg aaagcgggtc atacagctca gcaggaagac ttttgagaca 3120
gaatttcaga aaacaaaaaa tcaagagtgg gactttgtca taacaactga catctcagag 3180
atgggcgcca acttcaaggc tgaccgggtc atagactcta ggagatgcct aaaaccagtc 3240
atacttgatg gtgagagagt catcttggct gggcccatgc ctgtcacgca tgctagtgct 3300
gctcagagga gaggacgtat aggcaggaac cctaacaaac ctggagatga gtacatgtat 3360
ggaggtgggt gtgcagagac tgatgaaggc catgcacact ggcttgaagc aagaatgctt 3420
cttgacaaca tctacctcca ggatggcctc atagcctcgc tctatcggcc tgaggccgat 3480
aaggtagccg ccattgaggg agagtttaag ctgaggacag agcaaaggaa gaccttcgtg 3540
gaactcatga agagaggaga ccttcccgtc tggctagcct atcaggttgc atctgccgga 3600
ataacttaca cagacagaag atggtgcttt gatggcacaa ccaacaacac cataatggaa 3660
gacagcgtac cagcagaggt gtggacaaag tatggagaga agagagtgct caaaccgaga 3720
tggatggatg ctagggtctg ttcagaccat gcggccctga agtcgttcaa agaattcgcc 3780
gctggaaaaa gaggagcggc tttgggagta atggaggccc tgggaacact gccaggacac 3840
atgacagaga ggtttcagga agccattgac aacctcgccg tgctcatgcg agcagagact 3900
ggaagcaggc cttataaggc agcggcagcc caactgccgg agaccctaga gaccattatg 3960
ctcttaggtt tgctgggaac agtttcactg gggatcttct tcgtcttgat gcggaataag 4020
ggcatcggga agatgggctt tggaatggta acccttgggg ccagtgcatg gctcatgtgg 4080
ctttcggaaa ttgaaccagc cagaattgca tgtgtcctca ttgttgtgtt tttattactg 4140
gtggtgctca tacccgagcc agagaagcaa agatctcccc aagataacca gatggcaatt 4200
atcatcatgg tggcagtggg ccttctaggt ttgataactg caaacgaact tggatggctg 4260
gaaagaacaa aaaatgacat agctcatcta atgggaagga gagaagaagg agcaaccatg 4320
ggattctcaa tggacattga tctgcggcca gcctccgcct gggctatcta tgccgcattg 4380
acaactctca tcaccccagc tgtccaacat gcggtaacca cttcatacaa caactactcc 4440
ttaatggcga tggccacaca agctggagtg ctgtttggca tgggcaaagg gatgccattt 4500
tatgcatggg accttggagt cccgctgcta atgatgggtt gctattcaca attaacaccc 4560
ctgactctga tagtagctat cattctgctt gtggcgcact acatgtactt gatcccaggc 4620
ctacaagcgg cagcagcgcg tgctgcccag aaaaggacag cagctggcat catgaagaat 4680
cccgttgtgg atggaatagt ggtaactgac attgacacaa tgacaataga cccccaggtg 4740
gagaagaaga tgggacaagt gttactcata gcagtagcca tctccagtgc tgtgctgctg 4800
cggaccgcct ggggatgggg ggaggctgga gctctgatca cagcagcgac ctccaccttg 4860
tgggaaggct ctccaaacaa atactggaac tcctctacag ccacctcact gtgcaacatc 4920
ttcagaggaa gctatctggc aggagcttcc cttatctata cagtgacgag aaacgctggc 4980
ctggttaaga gacgtggagg tgggacggga gagactctgg gagagaagtg gaaagctcgt 5040
ctgaatcaga tgtcggccct ggagttctac tcttataaaa agtcaggtat cactgaagtg 5100
tgtagagagg aggctcgccg tgccctcaag gatggagtgg ccacaggagg acatgccgta 5160
tcccggggaa gtgcaaagct cagatggttg gtggagagag gatatctgca gccctatggg 5220
aaggttgttg acctcggatg tggcagaggg ggctggagct attatgccgc caccatccgc 5280
aaagtgcagg aggtgagagg atacacaaag ggaggtcccg gtcatgaaga acccatgctg 5340
gtgcaaagct atgggtggaa catagttcgt ctcaagagtg gagtggacgt cttccacatg 5400
gcggctgagc cgtgtgacac tctgctgtgt gacataggtg agtcatcatc tagtcctgaa 5460
gtggaagaga cacgaacact cagagtgctc tctatggtgg gggactggct tgaaaaaaga 5520
ccaggggcct tctgtataaa ggtgctgtgc ccatacacca gcactatgat ggaaaccatg 5580
gagcgactgc aacgtaggca tgggggagga ttagtcagag tgccattgtc tcgcaactcc 5640
acacatgaga tgtactgggt ctctggggca aagagcaaca tcataaaaag tgtgtccacc 5700
acaagtcagc tcctcctggg acgcatggat ggccccagga ggccagtgaa atatgaggag 5760
gatgtgaacc tcggctcggg tacacgagct gtggcaagct gtgctgaggc tcctaacatg 5820
aaaatcatcg gcaggcgcat tgagagaatc cgcaatgaac atgcagaaac atggtttctt 5880
gatgaaaacc acccatacag gacatgggcc taccatggga gctacgaagc ccccacgcaa 5940
ggatcagcgt cttccctcgt gaacggggtt gttagactcc tgtcaaagcc ttgggacgtg 6000
gtgactggag ttacaggaat agccatgact gacaccacac catacggcca acaaagagtc 6060
ttcaaagaaa aagtggacac cagggtgcca gatccccaag aaggcactcg ccaggtaatg 6120
aacatagtct cttcctggct gtggaaggag ctggggaaac gcaagcggcc acgcgtctgc 6180
accaaagaag agtttatcaa caaggtgcgc agcaatgcag cactgggagc aatatttgaa 6240
gaggaaaaag aatggaagac ggctgtggaa gctgtgaatg atccaaggtt ttgggcccta 6300
gtggataggg agagagaaca ccacctgaga ggagagtgtc acagctgtgt gtacaacatg 6360
atgggaaaaa gagaaaagaa gcaaggagag ttcgggaaag caaaaggtag ccgcgccatc 6420
tggtacatgt ggttgggagc cagattcttg gagtttgaag cccttggatt cttgaacgag 6480
gaccattgga tgggaagaga aaactcagga ggtggagtcg aagggttagg attgcaaaga 6540
cttggataca ttctagaaga aatgaatcgg gcaccaggag gaaagatgta cgcagatgac 6600
actgctggct gggacacccg cattagtaag tttgatctgg agaatgaagc tctgattacc 6660
aaccaaatgg aggaagggca cagaactctg gcgttggccg tgattaaata cacataccaa 6720
aacaaagtgg tgaaggttct cagaccagct gaaggaggaa aaacagttat ggacatcatt 6780
tcaagacaag accagagagg gagtggacaa gttgtcactt atgctctcaa cacattcacc 6840
aacttggtgg tgcagcttat ccggaacatg gaagctgagg aagtgttaga gatgcaagac 6900
ttatggttgt tgaggaagcc agagaaagtg accagatggt tgcagagcaa tggatgggat 6960
agactcaaac gaatggcggt cagtggagat gactgcgttg tgaagccaat cgatgatagg 7020
tttgcacatg ccctcaggtt cttgaatgac atgggaaaag ttaggaaaga cacacaggag 7080
tggaaaccct cgactggatg gagcaattgg gaagaagtcc cgttctgctc ccaccacttc 7140
aacaagctgt acctcaagga tgggagatcc attgtggtcc cttgccgcca ccaagatgaa 7200
ctgattggcc gagctcgcgt ctcaccaggg gcaggatgga gcatccggga gactgcctgt 7260
cttgcaaaat catatgcgca gatgtggcag ctcctttatt tccacagaag agaccttcga 7320
ctgatggcta atgccatttg ctcggctgtg ccagttgact gggtaccaac tgggagaacc 7380
acctggtcaa tccatggaaa gggagaatgg atgaccactg aggacatgct catggtgtgg 7440
aatagagtgt ggattgagga gaacgaccat atggaggaca agactcctgt aacaaaatgg 7500
acagacattc cctatctagg aaaaagggag gacttatggt gtggatccct tatagggcac 7560
agaccccgca ccacttgggc tgaaaacatc aaagacacag tcaacatggt gcgcaggatc 7620
ataggtgatg aagaaaagta catggactat ctatccaccc aagtccgcta cttgggtgag 7680
gaagggtcca cacccggagt gttgtaagca ccaattttag tgttgtcagg cctgctagtc 7740
agccacagtt tggggaaagc tgtgcagcct gtaacccccc caggagaagc tgggaaacca 7800
agctcatagt caggccgaga acgccatggc acggaagaag ccatgctgcc tgtgagcccc 7860
tcagaggaca ctgagtcaaa aaaccccacg cgcttggaag cgcaggatgg gaaaagaagg 7920
tggcgacctt ccccaccctt caatctgggg cctgaactgg agactagctg tgaatctcca 7980
gcagagggac tagtggttag aggagacccc ccggaaaacg caaaacagca tattgacgct 8040
gggaaagacc agagactcca tgagtttcca ccacgctggc cgccaggcac agatcgccga 8100
acttcggcgg ccggtgtggg gaaatccatg gtttct 8136
<210> 30
<211> 10224
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 30
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1080
acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga 1140
ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1200
aacacaaggt gaggcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1260
attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1320
atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1380
ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttgtcaatga 1440
tacaggatat gaaactgacg aaaatagagc gaaagtcgag gttacgccta attcaccaag 1500
agcggaagca accttgggag gctttggaag cttaggactt gactgtgaac caaggacagg 1560
ccttgacttt tcagatctgt attacctgac catgaacaat aagcattggt tggtgcacaa 1620
agagtggttt catgacatcc cattgccttg gcatgctggg gcagacaccg gaactccaca 1680
ctggaacaac aaagaggcat tggtagaatt caaggatgcc cacgccaaga ggcaaaccgt 1740
cgtcgttctg gggagccagg aaggagccgt tcacacggct ctcgctggag ctctagaggc 1800
tgagatggat ggtgcaaagg gaaagctgtt ctctggccac ttgaaatgcc gcctaaaaat 1860
ggacaagctt agattgaagg gcgtgtcata ttccttgtgc actgcggcat tcacattcac 1920
caaggtccca gctgaaacac tgcatggaac agtcacagtg gaggtgcagt atgcagggac 1980
agatggaccc tgcaagatcc cagtccagat ggcggtggac atgcagaccc tgaccccagt 2040
tggaaggctg ataaccgcca accccgtgat tactgaaagc actgagaact caaagatgat 2100
gttggagctt gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa 2160
aatcacccac cactggcata ggagtggtag caccatcgga aaggcatttg aggccactgt 2220
gagaggcgcc aagagaatgg cagtcctggg ggatacagcc tgggacttcg gatcagtcgg 2280
gggtgtgttc aactcactgg gtaagggcat tcaccagatt tttggagcag ccttcaaatc 2340
actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tagtgtggtt 2400
aggtttgaac acaaagaatg gatctatctc cctcacatgc ttggccctgg ggggagtgat 2460
gatcttcctc tccacggctg tttctgctga tgtggggtgc tcagtggact tctcaaaaaa 2520
ggaaacgaga tgtggcacgg gggtattcat ctataatgat gttgaagcct ggagggaccg 2580
gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcctggga 2640
agaggggatc tgtgggatct catccgtttc aagaatggaa aacatcatgt ggaaatcagt 2700
agaaggggag ctcaatgcta tcctagagga gaatggagtt caactgacag ttgttgtggg 2760
atctgtaaaa aaccccatgt ggagaggtcc acaaagattg ccagtgcctg tgaatgagct 2820
gccccatggc tggaaagcct gggggaaatc gtattttgtt agggcggcaa agaccaacaa 2880
cagttttgtt gtcgacggtg acacactgaa ggaatgtccg cttgagcaca gagcatggaa 2940
tagttttctt gtggaggatc acgggtttgg agtcttccac accagtgtct ggcttaaggt 3000
cagagaagat tactcattag aatgtgaccc agccgtcata ggaacagctg ttaagggaag 3060
ggaggccgcg cacagtgatc tgggctattg gattgaaagt gaaaagaatg acacatggag 3120
gctgaagagg gcccacctga ttgagatgaa aacatgtgaa tggccaaagt ctcacacatt 3180
gtggacagat ggagtagaag aaagtgatct tatcataccc aagtctttag ctggtccact 3240
cagccaccac aacaccagag agggttacag aacccaagtg aaagggccat ggcacagtga 3300
agagcttgaa atccggtttg aggaatgtcc aggcaccaag gtttacgtgg aggagacatg 3360
cggaactaga ggaccatctc tgagatcaac tactgcaagt ggaagggtca ttgaggaatg 3420
gtgctgtagg gaatgcacaa tgcccccact atcgtttcga gcaaaagacg gctgctggta 3480
tggaatggag ataaggccca ggaaagaacc agagagcaac ttagtgaggt caatggtgac 3540
agcggggtca accgatcata tggaccactt ctctcttgga gtgcttgtga ttctactcat 3600
ggtgcaggag gggttgaaga agagaatgac cacaaagatc atcatgagca catcaatggc 3660
agtgctggta gtcatgatct tgggaggatt ttcaatgagt gacctggcca agcttgtgat 3720
cctgatgggt gctactttcg cagaaatgaa cactggagga gatgtagctc acttggcatt 3780
ggtagcggca tttaaagtca gaccagcctt gctggtctcc ttcattttca gagccaattg 3840
gacaccccgt gagagcatgc tgctagccct ggcttcgtgt cttctgcaaa ctgcgatctc 3900
tgctcttgaa ggtgacttga tggtcctcat taatggattt gctttggcct ggttggcaat 3960
tcgagcaatg gccgtgccac gcactgacaa catcgctcta ccaatcttgg ctgctctaac 4020
accactagct cgaggcacac tgctcgtggc atggagagcg ggcctggcta cttgtggagg 4080
gatcatgctc ctctccctga aagggaaagg tagtgtgaag aagaacctgc catttgtcat 4140
ggccctggga ttgacagctg tgagggtagt agaccctatt aatgtggtag gactactgtt 4200
actcacaagg agtgggaagc ggagctggcc ccctagtgaa gttctcacag ccgttggcct 4260
gatatgtgca ctggccggag ggtttgccaa ggcagacatt gagatggctg gacccatggc 4320
tgcagtaggc ttgctaattg tcagctatgt ggtctcggga aagagtgtgg acatgtacat 4380
tgaaagagca ggtgacatca catgggaaaa ggacgcggaa gtcactggaa acagtcctcg 4440
gcttgacgtg gcactggatg agagtggtga tttctccttg gtagaggaag atggtccacc 4500
catgagagag atcatactca aggtggtcct gatggccatc tgtggcatga acccaatagc 4560
tatacctttt gctgcaggag cgtggtatgt gtatgtgaag actgggaaaa ggagtggcgc 4620
cctctgggac gtgcctgctc ccaaagaagt gaagaaagga gagaccacag atggagtgta 4680
cagagtgatg actcgcagac tgctaggttc aacacaggtt ggagtgggag tcatgcaaga 4740
gggagtcttc cacaccatgt ggcacgttac aaaaggagcc gcactgagga gcggtgaggg 4800
aagacttgat ccatactggg gggatgtcaa gcaggacttg gtgtcatact gtgggccttg 4860
gaagttggat gcagcttggg atggactcag cgaggtacag cttttggccg tacctcccgg 4920
agagagggcc agaaacattc agaccctgcc tggaatattc aagacaaagg acggggacat 4980
cggagcagtt gctctggact accctgcagg gacctcagga tctccgatcc tagacaaatg 5040
tggaagagtg ataggactct atggcaatgg ggttgtgatc aagaatggaa gctatgttag 5100
tgctataacc cagggaaaga gggaggagga gactccggtt gaatgtttcg aaccctcgat 5160
gctgaagaag aagcagctaa ctgtcttgga tctgcatcca ggagccggaa aaaccaggag 5220
agttcttcct gaaatagtcc gtgaagccat aaaaaagaga ctccggacag tgatcttggc 5280
accaactagg gttgtcgctg ctgagatgga ggaggccttg agaggacttc cggtgcgtta 5340
catgacaaca gcagtcaacg tcacccattc tgggacagaa atcgttgatt tgatgtgcca 5400
tgccactttc acttcacgct tactacaacc catcagagtc cctaattaca atctctacat 5460
catggatgaa gcccacttca cagacccctc aagtatagct gcaagaggat acatatcaac 5520
aagggttgaa atgggcgagg cggctgccat ttttatgact gccacaccac caggaacccg 5580
tgatgcgttt cctgactcta actcaccaat catggacaca gaagtggaag tcccagagag 5640
agcctggagc tcaggctttg attgggtgac agaccattct gggaaaacag tttggttcgt 5700
tccaagcgtg agaaacggaa atgaaatcgc agcctgtctg acaaaggctg gaaagcgggt 5760
catacagctc agcaggaaga cttttgagac agaatttcag aaaacaaaaa atcaagagtg 5820
ggactttgtc ataacaactg acatctcaga gatgggcgcc aacttcaagg ctgaccgggt 5880
catagactct aggagatgcc taaaaccagt catacttgat ggtgagagag tcatcttggc 5940
tgggcccatg cctgtcacgc atgctagtgc tgctcagagg agaggacgta taggcaggaa 6000
ccctaacaaa cctggagatg agtacatgta tggaggtggg tgtgcagaga ctgatgaagg 6060
ccatgcacac tggcttgaag caagaatgct tcttgacaac atctacctcc aggatggcct 6120
catagcctcg ctctatcggc ctgaggccga taaggtagcc gccattgagg gagagtttaa 6180
gctgaggaca gagcaaagga agaccttcgt ggaactcatg aagagaggag accttcccgt 6240
ctggctagcc tatcaggttg catctgccgg aataacttac acagacagaa gatggtgctt 6300
tgatggcaca accaacaaca ccataatgga agacagcgta ccagcagagg tgtggacaaa 6360
gtatggagag aagagagtgc tcaaaccgag atggatggat gctagggtct gttcagacca 6420
tgcggccctg aagtcgttca aagaattcgc cgctggaaaa agaggagcgg ctttgggagt 6480
aatggaggcc ctgggaacac tgccaggaca catgacagag aggtttcagg aagccattga 6540
caacctcgcc gtgctcatgc gagcagagac tggaagcagg ccttataagg cagcggcagc 6600
ccaactgccg gagaccctag agaccattat gctcttaggt ttgctgggaa cagtttcact 6660
ggggatcttc ttcgtcttga tgcggaataa gggcatcggg aagatgggct ttggaatggt 6720
aacccttggg gccagtgcat ggctcatgtg gctttcggaa attgaaccag ccagaattgc 6780
atgtgtcctc attgttgtgt ttttattact ggtggtgctc atacccgagc cagagaagca 6840
aagatctccc caagataacc agatggcaat tatcatcatg gtggcagtgg gccttctagg 6900
tttgataact gcaaacgaac ttggatggct ggaaagaaca aaaaatgaca tagctcatct 6960
aatgggaagg agagaagaag gagcaaccat gggattctca atggacattg atctgcggcc 7020
agcctccgcc tgggctatct atgccgcatt gacaactctc atcaccccag ctgtccaaca 7080
tgcggtaacc acttcataca acaactactc cttaatggcg atggccacac aagctggagt 7140
gctgtttggc atgggcaaag ggatgccatt ttatgcatgg gaccttggag tcccgctgct 7200
aatgatgggt tgctattcac aattaacacc cctgactctg atagtagcta tcattctgct 7260
tgtggcgcac tacatgtact tgatcccagg cctacaagcg gcagcagcgc gtgctgccca 7320
gaaaaggaca gcagctggca tcatgaagaa tcccgttgtg gatggaatag tggtaactga 7380
cattgacaca atgacaatag acccccaggt ggagaagaag atgggacaag tgttactcat 7440
agcagtagcc atctccagtg ctgtgctgct gcggaccgcc tggggatggg gggaggctgg 7500
agctctgatc acagcagcga cctccacctt gtgggaaggc tctccaaaca aatactggaa 7560
ctcctctaca gccacctcac tgtgcaacat cttcagagga agctatctgg caggagcttc 7620
ccttatctat acagtgacga gaaacgctgg cctggttaag agacgtggag gtgggacggg 7680
agagactctg ggagagaagt ggaaagctcg tctgaatcag atgtcggccc tggagttcta 7740
ctcttataaa aagtcaggta tcactgaagt gtgtagagag gaggctcgcc gtgccctcaa 7800
ggatggagtg gccacaggag gacatgccgt atcccgggga agtgcaaagc tcagatggtt 7860
ggtggagaga ggatatctgc agccctatgg gaaggttgtt gacctcggat gtggcagagg 7920
gggctggagc tattatgccg ccaccatccg caaagtgcag gaggtgagag gatacacaaa 7980
gggaggtccc ggtcatgaag aacccatgct ggtgcaaagc tatgggtgga acatagttcg 8040
tctcaagagt ggagtggacg tcttccacat ggcggctgag ccgtgtgaca ctctgctgtg 8100
tgacataggt gagtcatcat ctagtcctga agtggaagag acacgaacac tcagagtgct 8160
ctctatggtg ggggactggc ttgaaaaaag accaggggcc ttctgtataa aggtgctgtg 8220
cccatacacc agcactatga tggaaaccat ggagcgactg caacgtaggc atgggggagg 8280
attagtcaga gtgccattgt ctcgcaactc cacacatgag atgtactggg tctctggggc 8340
aaagagcaac atcataaaaa gtgtgtccac cacaagtcag ctcctcctgg gacgcatgga 8400
tggccccagg aggccagtga aatatgagga ggatgtgtgt acaacatgat gggaaaaaga 8460
gaaaagaagc aaggagagtt cgggaaagca aaaggtagcc gcgccatctg gtacatgtgg 8520
ttgggagcca gattcttgga gtttgaagcc cttggattct tgaacgagga ccattggatg 8580
ggaagagaaa actcaggagg tggagtcgaa gggttaggat tgcaaagact tggatacatt 8640
ctagaagaaa tgaatcgggc accaggagga aagatgtacg cagatgacac tgctggctgg 8700
gacacccgca ttagtaagtt tgatctggag aatgaagctc tgattaccaa ccaaatggag 8760
gaagggcaca gaactctggc gttggccgtg attaaataca cataccaaaa caaagtggtg 8820
aaggttctca gaccagctga aggaggaaaa acagttatgg acatcatttc aagacaagac 8880
cagagaggga gtggacaagt tgtcacttat gctctcaaca cattcaccaa cttggtggtg 8940
cagcttatcc ggaacatgga agctgaggaa gtgttagaga tgcaagactt atggttgttg 9000
aggaagccag agaaagtgac cagatggttg cagagcaatg gatgggatag actcaaacga 9060
atggcggtca gtggagatga ctgcgttgtg aagccaatcg atgataggtt tgcacatgcc 9120
ctcaggttct tgaatgacat gggaaaagtt aggaaagaca cacaggagtg gaaaccctcg 9180
actggatgga gcaattggga agaagtcccg ttctgctccc accacttcaa caagctgtac 9240
ctcaaggatg ggagatccat tgtggtccct tgccgccacc aagatgaact gattggccga 9300
gctcgcgtct caccaggggc aggatggagc atccgggaga ctgcctgtct tgcaaaatca 9360
tatgcgcaga tgtggcagct cctttatttc cacagaagag accttcgact gatggctaat 9420
gccatttgct cggctgtgcc agttgactgg gtaccaactg ggagaaccac ctggtcaatc 9480
catggaaagg gagaatggat gaccactgag gacatgctca tggtgtggaa tagagtgtgg 9540
attgaggaga acgaccatat ggaggacaag actcctgtaa caaaatggac agacattccc 9600
tatctaggaa aaagggagga cttatggtgt ggatccctta tagggcacag accccgcacc 9660
acttgggctg aaaacatcaa agacacagtc aacatggtgc gcaggatcat aggtgatgaa 9720
gaaaagtaca tggactatct atccacccaa gtccgctact tgggtgagga agggtccaca 9780
cccggagtgt tgtaagcacc aattttagtg ttgtcaggcc tgctagtcag ccacagtttg 9840
gggaaagctg tgcagcctgt aaccccccca ggagaagctg ggaaaccaag ctcatagtca 9900
ggccgagaac gccatggcac ggaagaagcc atgctgcctg tgagcccctc agaggacact 9960
gagtcaaaaa accccacgcg cttggaagcg caggatggga aaagaaggtg gcgaccttcc 10020
ccacccttca atctggggcc tgaactggag actagctgtg aatctccagc agagggacta 10080
gtggttagag gagacccccc ggaaaacgca aaacagcata ttgacgctgg gaaagaccag 10140
agactccatg agtttccacc acgctggccg ccaggcacag atcgccgaac ttcggcggcc 10200
ggtgtgggga aatccatggt ttct 10224
<210> 31
<211> 10272
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 31
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 600
catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 660
tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 720
caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 780
gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 840
caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 900
ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 960
tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1020
gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1080
acaggacaag ccaacagttg acatagagtt ggtcacgacg acggttagta acatggccga 1140
ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1200
aacacaaggt gaggcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1260
attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1320
atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1380
ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttgtcaatga 1440
tacaggatat gaaactgacg aaaatagagc gaaagtcgag gttacgccta attcaccaag 1500
agcggaagca accttgggag gctttggaag cttaggactt gactgtgaac caaggacagg 1560
ccttgacttt tcagatctgt attacctgac catgaacaat aagcattggt tggtgcacaa 1620
agagtggttt catgacatcc cattgccttg gcatgctggg gcagacaccg gaactccaca 1680
ctggaacaac aaagaggcat tggtagaatt caaggatgcc cacgccaaga ggcaaaccgt 1740
cgtcgttctg gggagccagg aaggagccgt tcacacggct ctcgctggag ctctagaggc 1800
tgagatggat ggtgcaaagg gaaagctgtt ctctggccac ttgaaatgcc gcctaaaaat 1860
ggacaagctt agattgaagg gcgtgtcata ttccttgtgc actgcggcat tcacattcac 1920
caaggtccca gctgaaacac tgcatggaac agtcacagtg gaggtgcagt atgcagggac 1980
agatggaccc tgcaagatcc cagtccagat ggcggtggac atgcagaccc tgaccccagt 2040
tggaaggctg ataaccgcca accccgtgat tactgaaagc actgagaact caaagatgat 2100
gttggagctt gacccaccat ttggggattc ttacattgtc ataggagttg gggacaagaa 2160
aatcacccac cactggcata ggagtggtag caccatcgga aaggcatttg aggccactgt 2220
gagaggcgcc aagagaatgg cagtcctggg ggatacagcc tgggacttcg gatcagtcgg 2280
gggtgtgttc aactcactgg gtaagggcat tcaccagatt tttggagcag ccttcaaatc 2340
actgtttgga ggaatgtcct ggttctcaca gatcctcata ggcacgctgc tagtgtggtt 2400
aggtttgaac acaaagaatg gatctatctc cctcacatgc ttggccctgg ggggagtgat 2460
gatcttcctc tccacggctg tttctgctga tgtggggtgc tcagtggact tctcaaaaaa 2520
ggaaacgaga tgtggcacgg gggtattcat ctataatgat gttgaagcct ggagggaccg 2580
gtacaagtac catcctgact ccccccgcag attggcagca gcagtcaagc aggcctggga 2640
agaggggatc tgtgggatct catccgtttc aagaatggaa aacatcatgt ggaaatcagt 2700
agaaggggag ctcaatgcta tcctagagga gaatggagtt caactgacag ttgttgtggg 2760
atctgtaaaa aaccccatgt ggagaggtcc acaaagattg ccagtgcctg tgaatgagct 2820
gccccatggc tggaaagcct gggggaaatc gtattttgtt agggcggcaa agaccaacaa 2880
cagttttgtt gtcgacggtg acacactgaa ggaatgtccg cttgagcaca gagcatggaa 2940
tagttttctt gtggaggatc acgggtttgg agtcttccac accagtgtct ggcttaaggt 3000
cagagaagat tactcattag aatgtgaccc agccgtcata ggaacagctg ttaagggaag 3060
ggaggccgcg cacagtgatc tgggctattg gattgaaagt gaaaagaatg acacatggag 3120
gctgaagagg gcccacctga ttgagatgaa aacatgtgaa tggccaaagt ctcacacatt 3180
gtggacagat ggagtagaag aaagtgatct tatcataccc aagtctttag ctggtccact 3240
cagccaccac aacaccagag agggttacag aacccaagtg aaagggccat ggcacagtga 3300
agagcttgaa atccggtttg aggaatgtcc aggcaccaag gtttacgtgg aggagacatg 3360
cggaactaga ggaccatctc tgagatcaac tactgcaagt ggaagggtca ttgaggaatg 3420
gtgctgtagg gaatgcacaa tgcccccact atcgtttcga gcaaaagacg gctgctggta 3480
tggaatggag ataaggccca ggaaagaacc agagagcaac ttagtgaggt caatggtgac 3540
agcggggtca accgatcata tggaccactt ctctcttgga gtgcttgtga ttctactcat 3600
ggtgcaggag gggttgaaga agagaatgac cacaaagatc atcatgagca catcaatggc 3660
agtgctggta gtcatgatct tgggaggatt ttcaatgagt gacctggcca agcttgtgat 3720
cctgatgggt gctactttcg cagaaatgaa cactggagga gatgtagctc acttggcatt 3780
ggtagcggca tttaaagtca gaccagcctt gctggtctcc ttcattttca gagccaattg 3840
gacaccccgt gagagcatgc tgctagccct ggcttcgtgt cttctgcaaa ctgcgatctc 3900
tgctcttgaa ggtgacttga tggtcctcat taatggattt gctttggcct ggttggcaat 3960
tcgagcaatg gccgtgccac gcactgacaa catcgctcta ccaatcttgg ctgctctaac 4020
accactagct cgaggcacac tgctcgtggc atggagagcg ggcctggcta cttgtggagg 4080
gatcatgctc ctctccctga aagggaaagg tagtgtgaag aagaacctgc catttgtcat 4140
ggccctggga ttgacagctg tgagggtagt agaccctatt aatgtggtag gactactgtt 4200
actcacaagg agtgggaagc ggagctggcc ccctagtgaa gttctcacag ccgttggcct 4260
gatatgtgca ctggccggag ggtttgccaa ggcagacatt gagatggctg gacccatggc 4320
tgcagtaggc ttgctaattg tcagctatgt ggtctcggga aagagtgtgg acatgtacat 4380
tgaaagagca ggtgacatca catgggaaaa ggacgcggaa gtcactggaa acagtcctcg 4440
gcttgacgtg gcactggatg agagtggtga tttctccttg gtagaggaag atggtccacc 4500
catgagagag atcatactca aggtggtcct gatggccatc tgtggcatga acccaatagc 4560
tatacctttt gctgcaggag cgtggtatgt gtatgtgaag actgggaaaa ggagtggcgc 4620
cctctgggac gtgcctgctc ccaaagaagt gaagaaagga gagaccacag atggagtgta 4680
cagagtgatg actcgcagac tgctaggttc aacacaggtt ggagtgggag tcatgcaaga 4740
gggagtcttc cacaccatgt ggcacgttac aaaaggagcc gcactgagga gcggtgaggg 4800
aagacttgat ccatactggg gggatgtcaa gcaggacttg gtgtcatact gtgggccttg 4860
gaagttggat gcagcttggg atggactcag cgaggtacag cttttggccg tacctcccgg 4920
agagagggcc agaaacattc agaccctgcc tggaatattc aagacaaagg acggggacat 4980
cggagcagtt gctctggact accctgcagg gacctcagga tctccgatcc tagacaaatg 5040
tggaagagtg ataggactct atggcaatgg ggttgtgatc aagaatggaa gctatgttag 5100
tgctataacc cagggaaaga gggaggagga gactccggtt gaatgtttcg aaccctcgat 5160
gctgaagaag aagcagctaa ctgtcttgga tctgcatcca ggagccggaa aaaccaggag 5220
agttcttcct gaaatagtcc gtgaagccat aaaaaagaga ctccggacag tgatcttggc 5280
accaactagg gttgtcgctg ctgagatgga ggaggccttg agaggacttc cggtgcgtta 5340
catgacaaca gcagtcaacg tcacccattc tgggacagaa atcgttgatt tgatgtgcca 5400
tgccactttc acttcacgct tactacaacc catcagagtc cctaattaca atctctacat 5460
catggatgaa gcccacttca cagacccctc aagtatagct gcaagaggat acatatcaac 5520
aagggttgaa atgggcgagg cggctgccat ttttatgact gccacaccac caggaacccg 5580
tgatgcgttt cctgactcta actcaccaat catggacaca gaagtggaag tcccagagag 5640
agcctggagc tcaggctttg attgggtgac agaccattct gggaaaacag tttggttcgt 5700
tccaagcgtg agaaacggaa atgaaatcgc agcctgtctg acaaaggctg gaaagcgggt 5760
catacagctc agcaggaaga cttttgagac agaatttcag aaaacaaaaa atcaagagtg 5820
ggactttgtc ataacaactg acatctcaaa ccgagatgga tggatgctag ggtctgttca 5880
gaccatgcgg ccctgaagtc gttcaaagaa ttcgccgctg gaaaaagagg agcggctttg 5940
ggagtaatgg aggccctggg aacactgcca ggacacatga cagagaggtt tcaggaagcc 6000
attgacaacc tcgccgtgct catgcgagca gagactggaa gcaggcctta taaggcagcg 6060
gcagcccaac tgccggagac cctagagacc attatgctct taggtttgct gggaacagtt 6120
tcactgggga tcttcttcgt cttgatgcgg aataagggca tcgggaagat gggctttgga 6180
atggtaaccc ttggggccag tgcatggctc atgtggcttt cggaaattga accagccaga 6240
attgcatgtg tcctcattgt tgtgttttta ttactggtgg tgctcatacc cgagccagag 6300
aagcaaagat ctccccaaga taaccagatg gcaattatca tcatggtggc agtgggcctt 6360
ctaggtttga taactgcaaa cgaacttgga tggctggaaa gaacaaaaaa tgacatagct 6420
catctaatgg gaaggagaga agaaggagca accatgggat tctcaatgga cattgatctg 6480
cggccagcct ccgcctgggc tatctatgcc gcattgacaa ctctcatcac cccagctgtc 6540
caacatgcgg taaccacttc atacaacaac tactccttaa tggcgatggc cacacaagct 6600
ggagtgctgt ttggcatggg caaagggatg ccattttatg catgggacct tggagtcccg 6660
ctgctaatga tgggttgcta ttcacaatta acacccctga ctctgatagt agctatcatt 6720
ctgcttgtgg cgcactacat gtacttgatc ccaggcctac aagcggcagc agcgcgtgct 6780
gcccagaaaa ggacagcagc tggcatcatg aagaatcccg ttgtggatgg aatagtggta 6840
actgacattg acacaatgac aatagacccc caggtggaga agaagatggg acaagtgtta 6900
ctcatagcag tagccatctc cagtgctgtg ctgctgcgga ccgcctgggg atggggggag 6960
gctggagctc tgatcacagc agcgacctcc accttgtggg aaggctctcc aaacaaatac 7020
tggaactcct ctacagccac ctcactgtgc aacatcttca gaggaagcta tctggcagga 7080
gcttccctta tctatacagt gacgagaaac gctggcctgg ttaagagacg tggaggtggg 7140
acgggagaga ctctgggaga gaagtggaaa gctcgtctga atcagatgtc ggccctggag 7200
ttctactctt ataaaaagtc aggtatcact gaagtgtgta gagaggaggc tcgccgtgcc 7260
ctcaaggatg gagtggccac aggaggacat gccgtatccc ggggaagtgc aaagctcaga 7320
tggttggtgg agagaggata tctgcagccc tatgggaagg ttgttgacct cggatgtggc 7380
agagggggct ggagctatta tgccgccacc atccgcaaag tgcaggaggt gagaggatac 7440
acaaagggag gtcccggtca tgaagaaccc atgctggtgc aaagctatgg gtggaacata 7500
gttcgtctca agagtggagt ggacgtcttc cacatggcgg ctgagccgtg tgacactctg 7560
ctgtgtgaca taggtgagtc atcatctagt cctgaagtgg aagagacacg aacactcaga 7620
gtgctctcta tggtggggga ctggcttgaa aaaagaccag gggccttctg tataaaggtg 7680
ctgtgcccat acaccagcac tatgatggaa accatggagc gactgcaacg taggcatggg 7740
ggaggattag tcagagtgcc attgtctcgc aactccacac atgagatgta ctgggtctct 7800
ggggcaaaga gcaacatcat aaaaagtgtg tccaccacaa gtcagctcct cctgggacgc 7860
atggatggcc ccaggaggcc agtgaaatat gaggaggatg tgaacctcgg ctcgggtaca 7920
cgagctgtgg caagctgtgc tgaggctcct aacatgaaaa tcatcggcag gcgcattgag 7980
agaatccgca atgaacatgc agaaacatgg tttcttgatg aaaaccaccc atacaggaca 8040
tgggcctacc atgggagcta cgaagccccc acgcaaggat cagcgtcttc cctcgtgaac 8100
ggggttgtta gactcctgtc aaagccttgg gacgtggtga ctggagttac aggaatagcc 8160
atgactgaca ccacaccata cggccaacaa agagtcttca aagaaaaagt ggacaccagg 8220
gtgccagatc cccaagaagg cactcgccag gtaatgaaca tagtctcttc ctggctgtgg 8280
aaggagctgg ggaaacgcaa gcggccacgc gtctgcacca aagaagagtt tatcaacaag 8340
gtgcgcagca atgcagcact gggagcaata tttgaagagg aaaaagaatg gaagacggct 8400
gtggaagctg tgaatgatcc aaggttttgg gccctagtgg atagggagag agaacaccac 8460
ctgagaggag agtgtcacag ctgtgtgtac aacatgatgg gaaaaagaga aaagaagcaa 8520
ggagagttcg ggaaagcaaa aggtagccgc gccatctggt acatgtggtt gggagccaga 8580
ttcttggagt ttgaagccct tggattcttg aacgaggacc attggatggg aagagaaaac 8640
tcaggaggtg gagtcgaagg gttaggattg caaagacttg gatacattct agaagaaatg 8700
aatcgggcac caggaggaaa gatgtacgca gatgacactg ctggctggga cacccgcatt 8760
agtaagtttg atctggagaa tgaagctctg attaccaacc aaatggagga agggcacaga 8820
actctggcgt tggccgtgat taaatacaca taccaaaaca aagtggtgaa ggttctcaga 8880
ccagctgaag gaggaaaaac agttatggac atcatttcaa gacaagacca gagagggagt 8940
ggacaagttg tcacttatgc tctcaacaca ttcaccaact tggtggtgca gcttatccgg 9000
aacatggaag ctgaggaagt gttagagatg caagacttat ggttgttgag gaagccagag 9060
aaagtgacca gatggttgca gagcaatgga tgggatagac tcaaacgaat ggcggtcagt 9120
ggagatgact gcgttgtgaa gccaatcgat gataggtttg cacatgccct caggttcttg 9180
aatgacatgg gaaaagttag gaaagacaca caggagtgga aaccctcgac tggatggagc 9240
aattgggaag aagtcccgtt ctgctcccac cacttcaaca agctgtacct caaggatggg 9300
agatccattg tggtcccttg ccgccaccaa gatgaactga ttggccgagc tcgcgtctca 9360
ccaggggcag gatggagcat ccgggagact gcctgtcttg caaaatcata tgcgcagatg 9420
tggcagctcc tttatttcca cagaagagac cttcgactga tggctaatgc catttgctcg 9480
gctgtgccag ttgactgggt accaactggg agaaccacct ggtcaatcca tggaaaggga 9540
gaatggatga ccactgagga catgctcatg gtgtggaata gagtgtggat tgaggagaac 9600
gaccatatgg aggacaagac tcctgtaaca aaatggacag acattcccta tctaggaaaa 9660
agggaggact tatggtgtgg atcccttata gggcacagac cccgcaccac ttgggctgaa 9720
aacatcaaag acacagtcaa catggtgcgc aggatcatag gtgatgaaga aaagtacatg 9780
gactatctat ccacccaagt ccgctacttg ggtgaggaag ggtccacacc cggagtgttg 9840
taagcaccaa ttttagtgtt gtcaggcctg ctagtcagcc acagtttggg gaaagctgtg 9900
cagcctgtaa cccccccagg agaagctggg aaaccaagct catagtcagg ccgagaacgc 9960
catggcacgg aagaagccat gctgcctgtg agcccctcag aggacactga gtcaaaaaac 10020
cccacgcgct tggaagcgca ggatgggaaa agaaggtggc gaccttcccc acccttcaat 10080
ctggggcctg aactggagac tagctgtgaa tctccagcag agggactagt ggttagagga 10140
gaccccccgg aaaacgcaaa acagcatatt gacgctggga aagaccagag actccatgag 10200
tttccaccac gctggccgcc aggcacagat cgccgaactt cggcggccgg tgtggggaaa 10260
tccatggttt ct 10272
<210> 32
<211> 8137
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 32
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta aacaccagag agggttacag 600
aacccaagtg aaagggccat ggcacagtga agagcttgaa atccggtttg aggaatgtcc 660
aggcaccaag gtttacgtgg aggagacatg cggaactaga ggaccatctc tgagatcaac 720
tactgcaagt ggaagggtca ttgaggaatg gtgctgtagg gaatgcacaa tgcccccact 780
atcgtttcga gcaaaagacg gctgctggta tggaatggag ataaggccca ggaaagaacc 840
agagagcaac ttagtgaggt caatggtgac agcggggtca accgatcata tggaccactt 900
ctctcttgga gtgcttgtga ttctactcat ggtgcaggag gggttgaaga agagaatgac 960
cacaaagatc atcatgagca catcaatggc agtgctggta gtcatgatct tgggaggatt 1020
ttcaatgagt gacctggcca agcttgtgat cctgatgggt gctactttcg cagaaatgaa 1080
cactggagga gatgtagctc acttggcatt ggtagcggca tttaaagtca gaccagcctt 1140
gctggtctcc ttcattttca gagccaattg gacaccccgt gagagcatgc tgctagccct 1200
ggcttcgtgt cttctgcaaa ctgcgatctc tgctcttgaa ggtgacttga tggtcctcat 1260
taatggattt gctttggcct ggttggcaat tcgagcaatg gccgtgccac gcactgacaa 1320
catcgctcta ccaatcttgg ctgctctaac accactagct cgaggcacac tgctcgtggc 1380
atggagagcg ggcctggcta cttgtggagg gatcatgctc ctctccctga aagggaaagg 1440
tagtgtgaag aagaacctgc catttgtcat ggccctggga ttgacagctg tgagggtagt 1500
agaccctatt aatgtggtag gactactgtt actcacaagg agtgggaagc ggagctggcc 1560
ccctagtgaa gttctcacag ccgttggcct gatatgtgca ctggccggag ggtttgccaa 1620
ggcagacatt gagatggctg gacccatggc tgcagtaggc ttgctaattg tcagctatgt 1680
ggtctcggga aagagtgtgg acatgtacat tgaaagagca ggtgacatca catgggaaaa 1740
ggacgcggaa gtcactggaa acagtcctcg gcttgacgtg gcactggatg agagtggtga 1800
tttctccttg gtagaggaag atggtccacc catgagagag atcatactca aggtggtcct 1860
gatggccatc tgtggcatga acccaatagc tatacctttt gctgcaggag cgtggtatgt 1920
gtatgtgaag actgggaaaa ggagtggcgc cctctgggac gtgcctgctc ccaaagaagt 1980
gaagaaagga gagaccacag atggagtgta cagagtgatg actcgcagac tgctaggttc 2040
aacacaggtt ggagtgggag tcatgcaaga gggagtcttc cacaccatgt ggcacgttac 2100
aaaaggagcc gcactgagga gcggtgaggg aagacttgat ccatactggg gggatgtcaa 2160
gcaggacttg gtgtcatact gtgggccttg gaagttggat gcagcttggg atggactcag 2220
cgaggtacag cttttggccg tacctcccgg agagagggcc agaaacattc agaccctgcc 2280
tggaatattc aagacaaagg acggggacat cggagcagtt gctctggact accctgcagg 2340
gacctcagga tctccgatcc tagacaaatg tggaagagtg ataggactct atggcaatgg 2400
ggttgtgatc aagaatggaa gctatgttag tgctataacc cagggaaaga gggaggagga 2460
gactccggtt gaatgtttcg aaccctcgat gctgaagaag aagcagctaa ctgtcttgga 2520
tctgcatcca ggagccggaa aaaccaggag agttcttcct gaaatagtcc gtgaagccat 2580
aaaaaagaga ctccggacag tgatcttggc accaactagg gttgtcgctg ctgagatgga 2640
ggaggccttg agaggacttc cggtgcgtta catgacaaca gcagtcaacg tcacccattc 2700
tgggacagaa atcgttgatt tgatgtgcca tgccactttc acttcacgct tactacaacc 2760
catcagagtc cctaattaca atctctacat catggatgaa gcccacttca cagacccctc 2820
aagtatagct gcaagaggat acatatcaac aagggttgaa atgggcgagg cggctgccat 2880
ttttatgact gccacaccac caggaacccg tgatgcgttt cctgactcta actcaccaat 2940
catggacaca gaagtggaag tcccagagag agcctggagc tcaggctttg attgggtgac 3000
agaccattct gggaaaacag tttggttcgt tccaagcgtg agaaacggaa atgaaatcgc 3060
agcctgtctg acaaaggctg gaaagcgggt catacagctc agcaggaaga cttttgagac 3120
agaatttcag aaaacaaaaa atcaagagtg ggactttgtc ataacaactg acatctcaga 3180
gatgggcgcc aacttcaagg ctgaccgggt catagactct aggagatgcc taaaaccagt 3240
catacttgat ggtgagagag tcatcttggc tgggcccatg cctgtcacgc atgctagtgc 3300
tgctcagagg agaggacgta taggcaggaa ccctaacaaa cctggagatg agtacatgta 3360
tggaggtggg tgtgcagaga ctgatgaagg ccatgcacac tggcttgaag caagaatgct 3420
tcttgacaac atctacctcc aggatggcct catagcctcg ctctatcggc ctgaggccga 3480
taaggtagcc gccattgagg gagagtttaa gctgaggaca gagcaaagga agaccttcgt 3540
ggaactcatg aagagaggag accttcccgt ctggctagcc tatcaggttg catctgccgg 3600
aataacttac acagacagaa gatggtgctt tgatggcaca accaacaaca ccataatgga 3660
agacagcgta ccagcagagg tgtggacaaa gtatggagag aagagagtgc tcaaaccgag 3720
atggatggat gctagggtct gttcagacca tgcggccctg aagtcgttca aagaattcgc 3780
cgctggaaaa agaggagcgg ctttgggagt aatggaggcc ctgggaacac tgccaggaca 3840
catgacagag aggtttcagg aagccattga caacctcgcc gtgctcatgc gagcagagac 3900
tggaagcagg ccttataagg cagcggcagc ccaactgccg gagaccctag agaccattat 3960
gctcttaggt ttgctgggaa cagtttcact ggggatcttc ttcgtcttga tgcggaataa 4020
gggcatcggg aagatgggct ttggaatggt aacccttggg gccagtgcat ggctcatgtg 4080
gctttcggaa attgaaccag ccagaattgc atgtgtcctc attgttgtgt ttttattact 4140
ggtggtgctc atacccgagc cagagaagca aagatctccc caagataacc agatggcaat 4200
tatcatcatg gtggcagtgg gccttctagg tttgataact gcaaacgaac ttggatggct 4260
ggaaagaaca aaaaatgaca tagctcatct aatgggaagg agagaagaag gagcaaccat 4320
gggattctca atggacattg atctgcggcc agcctccgcc tgggctatct atgccgcatt 4380
gacaactctc atcaccccag ctgtccaaca tgcggtaacc acttcataca acaactactc 4440
cttaatggcg atggccacac aagctggagt gctgtttggc atgggcaaag ggatgccatt 4500
ttatgcatgg gaccttggag tcccgctgct aatgatgggt tgctattcac aattaacacc 4560
cctgactctg atagtagcta tcattctgct tgtggcgcac tacatgtact tgatcccagg 4620
cctacaagcg gcagcagcgc gtgctgccca gaaaaggaca gcagctggca tcatgaagaa 4680
tcccgttgtg gatggaatag tggtaactga cattgacaca atgacaatag acccccaggt 4740
ggagaagaag atgggacaag tgttactcat agcagtagcc atctccagtg ctgtgctgct 4800
gcggaccgcc tggggatggg gggaggctgg agctctgatc acagcagcga cctccacctt 4860
gtgggaaggc tctccaaaca aatactggaa ctcctctaca gccacctcac tgtgcaacat 4920
cttcagagga agctatctgg caggagcttc ccttatctat acagtgacga gaaacgctgg 4980
cctggttaag agacgtggag gtgggacggg agagactctg ggagagaagt ggaaagctcg 5040
tctgaatcag atgtcggccc tggagttcta ctcttataaa aagtcaggta tcactgaagt 5100
gtgtagagag gaggctcgcc gtgccctcaa ggatggagtg gccacaggag gacatgccgt 5160
atcccgggga agtgcaaagc tcagatggtt ggtggagaga ggatatctgc agccctatgg 5220
gaaggttgtt gacctcggat gtggcagagg gggctggagc tattatgccg ccaccatccg 5280
caaagtgcag gaggtgagag gatacacaaa gggaggtccc ggtcatgaag aacccatgct 5340
ggtgcaaagc tatgggtgga acatagttcg tctcaagagt ggagtggacg tcttccacat 5400
ggcggctgag ccgtgtgaca ctctgctgtg tgacataggt gagtcatcat ctagtcctga 5460
agtggaagag acacgaacac tcagagtgct ctctatggtg ggggactggc ttgaaaaaag 5520
accaggggcc ttctgtataa aggtgctgtg cccatacacc agcactatga tggaaaccat 5580
ggagcgactg caacgtaggc atgggggagg attagtcaga gtgccattgt ctcgcaactc 5640
cacacatgag atgtactggg tctctggggc aaagagcaac atcataaaaa gtgtgtccac 5700
cacaagtcag ctcctcctgg gacgcatgga tggccccagg aggccagtga aatatgagga 5760
ggatgtgaac ctcggctcgg gtacacgagc tgtggcaagc tgtgctgagg ctcctaacat 5820
gaaaatcatc ggcaggcgca ttgagagaat ccgcaatgaa catgcagaaa catggtttct 5880
tgatgaaaac cacccataca ggacatgggc ctaccatggg agctacgaag cccccacgca 5940
aggatcagcg tcttccctcg tgaacggggt tgttagactc ctgtcaaagc cttgggacgt 6000
ggtgactgga gttacaggaa tagccatgac tgacaccaca ccatacggcc aacaaagagt 6060
cttcaaagaa aaagtggaca ccagggtgcc agatccccaa gaaggcactc gccaggtaat 6120
gaacatagtc tcttcctggc tgtggaagga gctggggaaa cgcaagcggc cacgcgtctg 6180
caccaaagaa gagtttatca acaaggtgcg cagcaatgca gcactgggag caatatttga 6240
agaggaaaaa gaatggaaga cggctgtgga agctgtgaat gatccaaggt tttgggccct 6300
agtggatagg gagagagaac accacctgag aggagagtgt cacagctgtg tgtacaacat 6360
gatgggaaaa agagaaaaga agcaaggaga gttcgggaaa gcaaaaggta gccgcgccat 6420
ctggtacatg tggttgggag ccagattctt ggagtttgaa gcccttggat tcttgaacga 6480
ggaccattgg atgggaagag aaaactcagg aggtggagtc gaagggttag gattgcaaag 6540
acttggatac attctagaag aaatgaatcg ggcaccagga ggaaagatgt acgcagatga 6600
cactgctggc tgggacaccc gcattagtaa gtttgatctg gagaatgaag ctctgattac 6660
caaccaaatg gaggaagggc acagaactct ggcgttggcc gtgattaaat acacatacca 6720
aaacaaagtg gtgaaggttc tcagaccagc tgaaggagga aaaacagtta tggacatcat 6780
ttcaagacaa gaccagagag ggagtggaca agttgtcact tatgctctca acacattcac 6840
caacttggtg gtgcagctta tccggaacat ggaagctgag gaagtgttag agatgcaaga 6900
cttatggttg ttgaggaagc cagagaaagt gaccagatgg ttgcagagca atggatggga 6960
tagactcaaa cgaatggcgg tcagtggaga tgactgcgtt gtgaagccaa tcgatgatag 7020
gtttgcacat gccctcaggt tcttgaatga catgggaaaa gttaggaaag acacacagga 7080
gtggaaaccc tcgactggat ggagcaattg ggaagaagtc ccgttctgct cccaccactt 7140
caacaagctg tacctcaagg atgggagatc cattgtggtc ccttgccgcc accaagatga 7200
actgattggc cgagctcgcg tctcaccagg ggcaggatgg agcatccggg agactgcctg 7260
tcttgcaaaa tcatatgcgc agatgtggca gctcctttat ttccacagaa gagaccttcg 7320
actgatggct aatgccattt gctcggctgt gccagttgac tgggtaccaa ctgggagaac 7380
cacctggtca atccatggaa agggagaatg gatgaccact gaggacatgc tcatggtgtg 7440
gaatagagtg tggattgagg agaacgacca tatggaggac aagactcctg taacaaaatg 7500
gacagacatt ccctatctag gaaaaaggga ggacttatgg tgtggatccc ttatagggca 7560
cagaccccgc accacttggg ctgaaaacat caaagacaca gtcaacatgg tgcgcaggat 7620
cataggtgat gaagaaaagt acatggacta tctatccacc caagtccgct acttgggtga 7680
ggaagggtcc acacccggag tgttgtaagc accaatttta gtgttgtcag gcctgctagt 7740
cagccacagt ttggggaaag ctgtgcagcc tgtaaccccc ccaggagaag ctgggaaacc 7800
aagctcatag tcaggccgag aacgccatgg cacggaagaa gccatgctgc ctgtgagccc 7860
ctcagaggac actgagtcaa aaaaccccac gcgcttggaa gcgcaggatg ggaaaagaag 7920
gtggcgacct tccccaccct tcaatctggg gcctgaactg gagactagct gtgaatctcc 7980
agcagaggga ctagtggtta gaggagaccc cccggaaaac gcaaaacagc atattgacgc 8040
tgggaaagac cagagactcc atgagtttcc accacgctgg ccgccaggca cagatcgccg 8100
aacttcggcg gccggtgtgg ggaaatccat ggtttct 8137
<210> 33
<211> 8137
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 33
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 60
agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa 120
gaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 180
ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 240
aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 300
tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 360
gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 420
cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 480
cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 540
ttcgtttgct accacattgg gagtgaacaa gtgccacgta cacaccagag agggttacag 600
aacccaagtg aaagggccat ggcacagtga agagcttgaa atccggtttg aggaatgtcc 660
aggcaccaag gtttacgtgg aggagacatg cggaactaga ggaccatctc tgagatcaac 720
tactgcaagt ggaagggtca ttgaggaatg gtgctgtagg gaatgcacaa tgcccccact 780
atcgtttcga gcaaaagacg gctgctggta tggaatggag ataaggccca ggaaagaacc 840
agagagcaac ttagtgaggt caatggtgac agcggggtca accgatcata tggaccactt 900
ctctcttgga gtgcttgtga ttctactcat ggtgcaggag gggttgaaga agagaatgac 960
cacaaagatc atcatgagca catcaatggc agtgctggta gtcatgatct tgggaggatt 1020
ttcaatgagt gacctggcca agcttgtgat cctgatgggt gctactttcg cagaaatgaa 1080
cactggagga gatgtagctc acttggcatt ggtagcggca tttaaagtca gaccagcctt 1140
gctggtctcc ttcattttca gagccaattg gacaccccgt gagagcatgc tgctagccct 1200
ggcttcgtgt cttctgcaaa ctgcgatctc tgctcttgaa ggtgacttga tggtcctcat 1260
taatggattt gctttggcct ggttggcaat tcgagcaatg gccgtgccac gcactgacaa 1320
catcgctcta ccaatcttgg ctgctctaac accactagct cgaggcacac tgctcgtggc 1380
atggagagcg ggcctggcta cttgtggagg gatcatgctc ctctccctga aagggaaagg 1440
tagtgtgaag aagaacctgc catttgtcat ggccctggga ttgacagctg tgagggtagt 1500
agaccctatt aatgtggtag gactactgtt actcacaagg agtgggaagc ggagctggcc 1560
ccctagtgaa gttctcacag ccgttggcct gatatgtgca ctggccggag ggtttgccaa 1620
ggcagacatt gagatggctg gacccatggc tgcagtaggc ttgctaattg tcagctatgt 1680
ggtctcggga aagagtgtgg acatgtacat tgaaagagca ggtgacatca catgggaaaa 1740
ggacgcggaa gtcactggaa acagtcctcg gcttgacgtg gcactggatg agagtggtga 1800
tttctccttg gtagaggaag atggtccacc catgagagag atcatactca aggtggtcct 1860
gatggccatc tgtggcatga acccaatagc tatacctttt gctgcaggag cgtggtatgt 1920
gtatgtgaag actgggaaaa ggagtggcgc cctctgggac gtgcctgctc ccaaagaagt 1980
gaagaaagga gagaccacag atggagtgta cagagtgatg actcgcagac tgctaggttc 2040
aacacaggtt ggagtgggag tcatgcaaga gggagtcttc cacaccatgt ggcacgttac 2100
aaaaggagcc gcactgagga gcggtgaggg aagacttgat ccatactggg gggatgtcaa 2160
gcaggacttg gtgtcatact gtgggccttg gaagttggat gcagcttggg atggactcag 2220
cgaggtacag cttttggccg tacctcccgg agagagggcc agaaacattc agaccctgcc 2280
tggaatattc aagacaaagg acggggacat cggagcagtt gctctggact accctgcagg 2340
gacctcagga tctccgatcc tagacaaatg tggaagagtg ataggactct atggcaatgg 2400
ggttgtgatc aagaatggaa gctatgttag tgctataacc cagggaaaga gggaggagga 2460
gactccggtt gaatgtttcg aaccctcgat gctgaagaag aagcagctaa ctgtcttgga 2520
tctgcatcca ggagccggaa aaaccaggag agttcttcct gaaatagtcc gtgaagccat 2580
aaaaaagaga ctccggacag tgatcttggc accaactagg gttgtcgctg ctgagatgga 2640
ggaggccttg agaggacttc cggtgcgtta catgacaaca gcagtcaacg tcacccattc 2700
tgggacagaa atcgttgatt tgatgtgcca tgccactttc acttcacgct tactacaacc 2760
catcagagtc cctaattaca atctctacat catggatgaa gcccacttca cagacccctc 2820
aagtatagct gcaagaggat acatatcaac aagggttgaa atgggcgagg cggctgccat 2880
ttttatgact gccacaccac caggaacccg tgatgcgttt cctgactcta actcaccaat 2940
catggacaca gaagtggaag tcccagagag agcctggagc tcaggctttg attgggtgac 3000
agaccattct gggaaaacag tttggttcgt tccaagcgtg agaaacggaa atgaaatcgc 3060
agcctgtctg acaaaggctg gaaagcgggt catacagctc agcaggaaga cttttgagac 3120
agaatttcag aaaacaaaaa atcaagagtg ggactttgtc ataacaactg acatctcaga 3180
gatgggcgcc aacttcaagg ctgaccgggt catagactct aggagatgcc taaaaccagt 3240
catacttgat ggtgagagag tcatcttggc tgggcccatg cctgtcacgc atgctagtgc 3300
tgctcagagg agaggacgta taggcaggaa ccctaacaaa cctggagatg agtacatgta 3360
tggaggtggg tgtgcagaga ctgatgaagg ccatgcacac tggcttgaag caagaatgct 3420
tcttgacaac atctacctcc aggatggcct catagcctcg ctctatcggc ctgaggccga 3480
taaggtagcc gccattgagg gagagtttaa gctgaggaca gagcaaagga agaccttcgt 3540
ggaactcatg aagagaggag accttcccgt ctggctagcc tatcaggttg catctgccgg 3600
aataacttac acagacagaa gatggtgctt tgatggcaca accaacaaca ccataatgga 3660
agacagcgta ccagcagagg tgtggacaaa gtatggagag aagagagtgc tcaaaccgag 3720
atggatggat gctagggtct gttcagacca tgcggccctg aagtcgttca aagaattcgc 3780
cgctggaaaa agaggagcgg ctttgggagt aatggaggcc ctgggaacac tgccaggaca 3840
catgacagag aggtttcagg aagccattga caacctcgcc gtgctcatgc gagcagagac 3900
tggaagcagg ccttataagg cagcggcagc ccaactgccg gagaccctag agaccattat 3960
gctcttaggt ttgctgggaa cagtttcact ggggatcttc ttcgtcttga tgcggaataa 4020
gggcatcggg aagatgggct ttggaatggt aacccttggg gccagtgcat ggctcatgtg 4080
gctttcggaa attgaaccag ccagaattgc atgtgtcctc attgttgtgt ttttattact 4140
ggtggtgctc atacccgagc cagagaagca aagatctccc caagataacc agatggcaat 4200
tatcatcatg gtggcagtgg gccttctagg tttgataact gcaaacgaac ttggatggct 4260
ggaaagaaca aaaaatgaca tagctcatct aatgggaagg agagaagaag gagcaaccat 4320
gggattctca atggacattg atctgcggcc agcctccgcc tgggctatct atgccgcatt 4380
gacaactctc atcaccccag ctgtccaaca tgcggtaacc acttcataca acaactactc 4440
cttaatggcg atggccacac aagctggagt gctgtttggc atgggcaaag ggatgccatt 4500
ttatgcatgg gaccttggag tcccgctgct aatgatgggt tgctattcac aattaacacc 4560
cctgactctg atagtagcta tcattctgct tgtggcgcac tacatgtact tgatcccagg 4620
cctacaagcg gcagcagcgc gtgctgccca gaaaaggaca gcagctggca tcatgaagaa 4680
tcccgttgtg gatggaatag tggtaactga cattgacaca atgacaatag acccccaggt 4740
ggagaagaag atgggacaag tgttactcat agcagtagcc atctccagtg ctgtgctgct 4800
gcggaccgcc tggggatggg gggaggctgg agctctgatc acagcagcga cctccacctt 4860
gtgggaaggc tctccaaaca aatactggaa ctcctctaca gccacctcac tgtgcaacat 4920
cttcagagga agctatctgg caggagcttc ccttatctat acagtgacga gaaacgctgg 4980
cctggttaag agacgtggag gtgggacggg agagactctg ggagagaagt ggaaagctcg 5040
tctgaatcag atgtcggccc tggagttcta ctcttataaa aagtcaggta tcactgaagt 5100
gtgtagagag gaggctcgcc gtgccctcaa ggatggagtg gccacaggag gacatgccgt 5160
atcccgggga agtgcaaagc tcagatggtt ggtggagaga ggatatctgc agccctatgg 5220
gaaggttgtt gacctcggat gtggcagagg gggctggagc tattatgccg ccaccatccg 5280
caaagtgcag gaggtgagag gatacacaaa gggaggtccc ggtcatgaag aacccatgct 5340
ggtgcaaagc tatgggtgga acatagttcg tctcaagagt ggagtggacg tcttccacat 5400
ggcggctgag ccgtgtgaca ctctgctgtg tgacataggt gagtcatcat ctagtcctga 5460
agtggaagag acacgaacac tcagagtgct ctctatggtg ggggactggc ttgaaaaaag 5520
accaggggcc ttctgtataa aggtgctgtg cccatacacc agcactatga tggaaaccat 5580
ggagcgactg caacgtaggc atgggggagg attagtcaga gtgccattgt ctcgcaactc 5640
cacacatgag atgtactggg tctctggggc aaagagcaac atcataaaaa gtgtgtccac 5700
cacaagtcag ctcctcctgg gacgcatgga tggccccagg aggccagtga aatatgagga 5760
ggatgtgaac ctcggctcgg gtacacgagc tgtggcaagc tgtgctgagg ctcctaacat 5820
gaaaatcatc ggcaggcgca ttgagagaat ccgcaatgaa catgcagaaa catggtttct 5880
tgatgaaaac cacccataca ggacatgggc ctaccatggg agctacgaag cccccacgca 5940
aggatcagcg tcttccctcg tgaacggggt tgttagactc ctgtcaaagc cttgggacgt 6000
ggtgactgga gttacaggaa tagccatgac tgacaccaca ccatacggcc aacaaagagt 6060
cttcaaagaa aaagtggaca ccagggtgcc agatccccaa gaaggcactc gccaggtaat 6120
gaacatagtc tcttcctggc tgtggaagga gctggggaaa cgcaagcggc cacgcgtctg 6180
caccaaagaa gagtttatca acaaggtgcg cagcaatgca gcactgggag caatatttga 6240
agaggaaaaa gaatggaaga cggctgtgga agctgtgaat gatccaaggt tttgggccct 6300
agtggatagg gagagagaac accacctgag aggagagtgt cacagctgtg tgtacaacat 6360
gatgggaaaa agagaaaaga agcaaggaga gttcgggaaa gcaaaaggta gccgcgccat 6420
ctggtacatg tggttgggag ccagattctt ggagtttgaa gcccttggat tcttgaacga 6480
ggaccattgg atgggaagag aaaactcagg aggtggagtc gaagggttag gattgcaaag 6540
acttggatac attctagaag aaatgaatcg ggcaccagga ggaaagatgt acgcagatga 6600
cactgctggc tgggacaccc gcattagtaa gtttgatctg gagaatgaag ctctgattac 6660
caaccaaatg gaggaagggc acagaactct ggcgttggcc gtgattaaat acacatacca 6720
aaacaaagtg gtgaaggttc tcagaccagc tgaaggagga aaaacagtta tggacatcat 6780
ttcaagacaa gaccagagag ggagtggaca agttgtcact tatgctctca acacattcac 6840
caacttggtg gtgcagctta tccggaacat ggaagctgag gaagtgttag agatgcaaga 6900
cttatggttg ttgaggaagc cagagaaagt gaccagatgg ttgcagagca atggatggga 6960
tagactcaaa cgaatggcgg tcagtggaga tgactgcgtt gtgaagccaa tcgatgatag 7020
gtttgcacat gccctcaggt tcttgaatga catgggaaaa gttaggaaag acacacagga 7080
gtggaaaccc tcgactggat ggagcaattg ggaagaagtc ccgttctgct cccaccactt 7140
caacaagctg tacctcaagg atgggagatc cattgtggtc ccttgccgcc accaagatga 7200
actgattggc cgagctcgcg tctcaccagg ggcaggatgg agcatccggg agactgcctg 7260
tcttgcaaaa tcatatgcgc agatgtggca gctcctttat ttccacagaa gagaccttcg 7320
actgatggct aatgccattt gctcggctgt gccagttgac tgggtaccaa ctgggagaac 7380
cacctggtca atccatggaa agggagaatg gatgaccact gaggacatgc tcatggtgtg 7440
gaatagagtg tggattgagg agaacgacca tatggaggac aagactcctg taacaaaatg 7500
gacagacatt ccctatctag gaaaaaggga ggacttatgg tgtggatccc ttatagggca 7560
cagaccccgc accacttggg ctgaaaacat caaagacaca gtcaacatgg tgcgcaggat 7620
cataggtgat gaagaaaagt acatggacta tctatccacc caagtccgct acttgggtga 7680
ggaagggtcc acacccggag tgttgtaagc accaatttta gtgttgtcag gcctgctagt 7740
cagccacagt ttggggaaag ctgtgcagcc tgtaaccccc ccaggagaag ctgggaaacc 7800
aagctcatag tcaggccgag aacgccatgg cacggaagaa gccatgctgc ctgtgagccc 7860
ctcagaggac actgagtcaa aaaaccccac gcgcttggaa gcgcaggatg ggaaaagaag 7920
gtggcgacct tccccaccct tcaatctggg gcctgaactg gagactagct gtgaatctcc 7980
agcagaggga ctagtggtta gaggagaccc cccggaaaac gcaaaacagc atattgacgc 8040
tgggaaagac cagagactcc atgagtttcc accacgctgg ccgccaggca cagatcgccg 8100
aacttcggcg gccggtgtgg ggaaatccat ggtttct 8137
<210> 34
<211> 9163
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 34
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacgagctt ggtccctatc ctcgaaacag cggggataaa actaaatgat 480
aggcagtggt ctcagataat tcaagccttc aaagaagaca aagcatactc acctgaagta 540
gccctgaatg aaatatgtac gcgcatgtat ggggtggatc tagacagcgg gctattttct 600
aaaccgttgg tgtctgtgta ttacgcggat aaccactggg ataataggcc tggagggaaa 660
atgttcggat ttaaccccga ggcagcatcc attctagaaa gaaagtatcc attcacaaaa 720
gggaagtgga acatcaacaa gcagatctgc gtgactacca ggaggataga agactttaac 780
cctaccacca acatcatacc ggccaacagg agactaccac actcattagt ggccgaacac 840
cgcccagtaa aaggggaaag aatggaatgg ctggttaaca agataaacgg ccaccacgtg 900
ctcctggtca gtggctataa ccttgcactg cctactaaga gagtcacttg ggtagcgccg 960
ttaggtgtcc gtggagcgga ctacacatac aacctagagt tgggtctgcc agcaacgctt 1020
ggtaggtatg acctagtggt cataaacatc cacacacctt ttcgcataca ccattaccaa 1080
cagtgcgtcg accacgcaat gaaactgcaa atgctcgggg gtgactcatt gagactgctc 1140
aaaccgggcg gctctctatt gatcagagca tatggttacg cagatagaac cagtgaacga 1200
gtcatctgcg tattgggacg caagtttaga tcgtctagag cgttgaaacc accatgtgtc 1260
accagcaaca ctgagatgtt tttcctattc agcaactttg acaatggcag aaggaatttc 1320
acaactcatg tcatgaacaa tcaactgaat gcagccttcg taggacaggt cacccgagca 1380
ggatgtgcac cgtcgtaccg ggtaaaacgc atggacatcg cgaagaacga tgaagagtgc 1440
gtagtcaacg ccgctaaccc tcgcgggtta ccgggtgacg gtgtttgcaa ggcagtatac 1500
aaaaaatggc cggagtcctt taagaacagt gcaacaccag tgggaaccgc aaaaacagtt 1560
atgtgcggta cgtatccagt aatccacgct gttggaccaa acttctctaa ttattcggag 1620
tctgaagggg accgggaatt ggcagctgcc tatcgagaag tcgcaaagga agtaactagg 1680
ctgggagtaa atagtgtagc tatacctctc ctctccacag gtgtatactc aggagggaaa 1740
gacaggctga cccagtcact gaaccacctc tttacagcca tggactcgac ggatgcagac 1800
gtggtcatct actgccgcga caaagaatgg gagaagaaaa tatctgaggc catacagatg 1860
cggacccaag tagagctgct ggatgagcac atctccatag actgcgatat tgttcgcgtg 1920
caccctgaca gcagcttggc aggcagaaaa ggatacagca ccacggaagg cgcactgtac 1980
tcatatctag aagggacccg ttttcatcag acggctgtgg atatggcgga gatacatact 2040
atgtggccaa agcaaacaga ggccaatgag caagtctgcc tatatgccct gggggaaagt 2100
attgaatcga tcaggcagaa atgcccggtg gatgatgcag acgcatcatc tccccccaaa 2160
actgtcccgt gcctttgccg ttacgctatg actccagaac gcgtcacccg gcttcgcatg 2220
aaccacgtca caagcataat tgtgtgttct tcgtttcccc tcccaaagta caaaatagaa 2280
ggagtgcaaa aagtcaaatg ctctaaggta atgctatttg accacaacgt gccatcgcgc 2340
gtaagtccaa gggaatatag atcttcccag gagtctgcac aggaggcgag tacaatcacg 2400
tcactgacgc atagtcaatt cgacctaagc gttgatggcg agatactgcc cgtcccgtca 2460
gacctggatg ctgacgcccc agccctagaa ccagcactag acgacggggc gacacacacg 2520
ctgccatcca caaccggaaa ccttgcggcc gtgtctgatt gggtaatgag caccgtacct 2580
gtcgcgccgc ccagaagaag gcgagggaga aacctgactg tgacatgtga cgagagagaa 2640
gggaatataa cacccatggc tagcgtccga ttctttaggg cagagctgtg tccggtcgta 2700
caagaaacag cggagacgcg tgacacagca atgtctcttc aggcaccacc gagtaccgcc 2760
acggaaccga atcatccgcc gatctccttc ggagcatcaa gcgagacgtt ccccattaca 2820
tttggggact tcaacgaagg agaaatcgaa agcttgtctt ctgagctact aactttcgga 2880
gacttcttac caggagaagt ggatgacttg acagacagcg actggtccac gtgctcagac 2940
acggacgacg agttatgact agacagggca ggtgggtata tattctcgtc ggacaccggt 3000
ccaggtcatt tacaacagaa gtcagtacgc cagtcagtgc tgccggtgaa caccctggag 3060
gaagtccacg aggagaagtg ttacccacct aagctggatg aagcaaagga gcaactatta 3120
cttaagaaac tccaggagag tgcatccatg gccaacagaa gcaggtatca gtcgcgcaaa 3180
gtagaaaaca tgaaagcagc aatcatccag agactaaaga gaggctgtag actatactta 3240
atgtcagaga ccccaaaagt ccctacttac cggactacat atccggcgcc tgtgtactcg 3300
cctccgatca acgtccgatt gtccaatccc gagtccgcag tggcagcatg caatgagttc 3360
ttagctagaa actatccaac tgtctcatca taccaaatta ccgacgagta tgatgcatat 3420
ctagacatgg tggacgggtc ggagagttgc ctggaccgag cgacattcaa tccgtcaaaa 3480
ctcaggagct acccgaaaca gcacgcttac cacgcgccct ccatcagaag cgctgtaccg 3540
tccccattcc agaacacact acagaatgta ctggcagcag ccacgaaaag aaactgcaac 3600
gtcacacaga tgagggaatt acccactttg gactcagcag tattcaacgt ggagtgtttc 3660
aaaaaattcg catgcaacca agaatactgg gaagaatttg ctgccagccc tattaggata 3720
acaactgaga atttagcaac ctatgttact aaactaaaag ggccaaaagc agcagcgcta 3780
ttcgcaaaaa cccataatct actgccacta caggaagtac caatggatag gttcacagta 3840
gatatgaaaa gggacgtaaa ggtgactcct ggtacaaagc atacagagga aagacctaag 3900
gtgcaggtta tacaggcggc tgaacccttg gcgacagcat acctatgtgg gattcacaga 3960
gagctggtta ggaggctgaa cgccgtcctc ctacccaatg tacatacact atttgacatg 4020
tctgccgagg atttcgatgc catcatagcc gcacacttta agccaggaga cactgttttg 4080
gaaacggaca tagcctcctt tgataagagc caagatgatt cacttgcgct tactgctttg 4140
atgctgttag aggatttagg ggtggatcac tccctgctgg acttgataga ggctgctttc 4200
ggagagattt ccagctgtca cctaccgaca ggtacgcgct tcaagttcgg cgccatgatg 4260
aaatcaggta tgttcctaac tctgttcgtc aacacattgt taaacatcac catcgccagc 4320
cgagtgctgg aagatcgtct gacaaaatcc gcgtgcgcgg ccttcatcgg cgacgacaac 4380
ataatacatg gagtcgtctc cgatgaattg atggcagcca gatgtgccac ttggatgaac 4440
atggaagtga agatcataga tgcagttgta tccttgaaag ccccttactt ttgtggaggg 4500
tttatactgc acgatactgt gacaggaaca gcttgcagag tggcagaccc gctaaaaagg 4560
ctttttaaac tgggcaaacc gctagcggca ggtgacgaac aagatgaaga tagaagacga 4620
gcgctggctg acgaagtgat cagatggcaa cgaacagggc taattgatga gctggagaaa 4680
gcggtatact ctaggtacga agtgcagggt atatcagttg tggtaatgtc catggccacc 4740
tttgcaagct ccagatccaa cttcgagaag ctcagaggac ccgtcataac tttgtacggc 4800
ggtcctaaat aggtacgcac tacagctacc tattttgcag aagccgacag caagtatcta 4860
aacactaatc agctacaatg gagttcatcc caacccaaac tttttacaat aggaggtacc 4920
agcctcgacc ctggactccg cgccctacta tccaagtcat caggcccaga ccgcgccctc 4980
agaggcaagc tgggcaactt gcccagctga tctcagcagt taataaactg acaatgcgcg 5040
cggtacccca acagaagcca cgcaggaatc ggaagaataa gaagcaaaag caaaaacaac 5100
aggcgccaca aaacaacaca aatcaaaaga agcagccacc taaaaagaaa ccggctcaaa 5160
agaaaaagaa gccgggccgc agagagagga tgtgcatgaa aatcgaaaat gattgtattt 5220
tcgaagtcaa gcacgaaggt aaggtaacag gttacgcgtg cctggtgggg gacaaagtaa 5280
tgaaaccagc acacgtaaag gggaccatcg ataacgcgga cctggccaaa ctggccttta 5340
agcggtcatc taagtatgac cttgaatgcg cgcagatacc cgtgcacatg aagtccgacg 5400
cttcgaagtt cacccatgag aaaccggagg ggtactacaa ctggcaccac ggagcagtac 5460
agtactcagg aggccggttc accatcccta caggtgctgg caaaccaggg gacagcggca 5520
gaccgatctt cgacaacaag ggacgcgtgg tggccatagt cttaggagga gctaatgaag 5580
gagcccgtac agccctctcg gtggtgacct ggaataaaga cattgtcact aaaatcaccc 5640
ccgagggggc cgaagagtgg agtcttgcca tcccagttat gtgcctgttg gcaaacacca 5700
cgttcccctg ctcccagccc ccttgcacgc cctgctgcta cgaaaaggaa ccggaggaaa 5760
ccctacgcat gcttgaggac aacgtcatga gacctgggta ctatcagctg ctacaagcat 5820
ccttaacatg ttctccccac cgccagcgac gcagcaccaa ggacaacttc aatgtctata 5880
aagccacaag accatactta gctcactgtc ccgactgtgg agaagggcac tcgtgccata 5940
gtcccgtagc actagaacgc atcagaaatg aagcgacaga cgggacgctg aaaatccagg 6000
tctccttgca aatcggaata aagacggatg acagccacga ttggaccaag ctgcgttata 6060
tggacaacca catgccagca gacgcagaga gggcggggct atttgtaaga acatcagcac 6120
cgtgtacgat tactggaaca atgggacact tcatcctggc ccgatgtcca aaaggggaaa 6180
ctctgacggt gggattcact gacagtagga agattagtca ctcatgtacg cacccatttc 6240
accacgaccc tcctgtgata ggtcgggaaa aattccattc ccgaccgcag cacggtaaag 6300
agctaccttg cagcacgtac gtgcagagca ccgccgcaac taccgaggag atagaggtac 6360
acatgccccc agacacccct gatcgcacat taatgtcaca acagtccggc aacgtaaaga 6420
tcacagtcaa tggccagacg gtgcggtaca agtgtaattg cggtggctca aatgaaggac 6480
taacaactac agacaaagtg attaataact gcaaggttga tcaatgtcat gccgcggtca 6540
ccaatcacaa aaagtggcag tataactccc ctctggtccc gcgtaatgct gaacttgggg 6600
accgaaaagg aaaaattcac atcccgtttc cgctggcaaa tgtaacatgc agggtgccta 6660
aagcaaggaa ccccaccgtg acgtacggga aaaaccaagt catcatgcta ctgtatcctg 6720
accacccaac actcctgtcc taccggaata tgggagaaga accaaactat caagaagagt 6780
gggtgatgca taagaaggaa gtcgtgctaa ccgtgccgac tgaagggctc gaggtcacgt 6840
ggggcaacaa cgagccgtat aagtattggc cgcagttatc tacaaacggt acagcccatg 6900
gccacccgca cgagataatt ctgtattatt atgagctgta ccccactatg actgtagtag 6960
ttgtgtcagt ggccacgttc atactcctgt cgatggtggg tatggcagcg gggatgtgca 7020
tgtgtgcacg acgcagatgc atcacaccgt atgaactgac accaggagct accgtccctt 7080
tcctgcttag cctaatatgc tgcatcagaa cagctaaagc ggccacatac caagaggctg 7140
cgatatacct gtggaacgag cagcaacctt tgttttggct acaagccctt attccgctgg 7200
cagccctgat tgttctatgc aactgtctga gactcttacc atgctgctgt aaaacgttgg 7260
cttttttagc cgtaatgagc gtcggtgccc acactgtgag cgcgtacgaa cacgtaacag 7320
tgatcccgaa cacggtggga gtaccgtata agactctagt caatagacct ggctacagcc 7380
ccatggtatt ggagatggaa ctactgtcag tcactttgga gccaacacta tcgcttgatt 7440
acatcacgtg cgagtacaaa accgtcatcc cgtctccgta cgtgaagtgc tgcggtacag 7500
cagagtgcaa ggacaaaaac ctacctgact acagctgtaa ggtcttcacc ggcgtctacc 7560
catttatgtg gggcggcgcc tactgcttct gcgacgctga aaacacgcag ttgagcgaag 7620
cacacgtgga gaagtccgaa tcatgcaaaa cagaatttgc atcagcatac agggctcata 7680
ccgcatctgc atcagctaag ctccgcgtcc tttaccaagg aaataacatc actgtaactg 7740
cctatgcaaa cggcgaccat gccgtcacag ttaaggacgc caaattcatt gtggggccaa 7800
tgtcttcagc ctggacacct ttcgacaaca aaattgtggt gtacaaaggt gacgtctata 7860
acatggacta cccgcccttt ggcgcaggaa gaccaggaca atttggcgat atccaaagtc 7920
gcacacctga gagtaaagac gtctatgcta atacacaact ggtactgcag agaccggctg 7980
tgggtacggt acacgtgcca tactctcagg caccatctgg ctttaagtat tggctaaaag 8040
aacgcggggc gtcgctgcag cacacagcac catttggctg ccaaatagca acaaacccgg 8100
taagagcggt gaactgcgcc gtagggaaca tgcccatctc catcgacata ccggaagcgg 8160
ccttcactag ggtcgtcgac gcgccctctt taacggacat gtcgtgcgag gtaccagcct 8220
gcacccattc ctcagacttt gggggcgtcg ccattattaa atatgcagcc agcaagaaag 8280
gcaagtgtgc ggtgcattcg atgactaacg ccgtcactat tcgggaagct gagatagaag 8340
ttgaagggaa ttctcagctg caaatctctt tctcgacggc cttagccagc gccgaattcc 8400
gcgtacaagt ctgttctaca caagtacact gtgcagccga gtgccacccc ccgaaggacc 8460
acatagtcaa ctacccggcg tcacatacca ccctcggggt ccaggacatc tccgctacgg 8520
cgatgtcatg ggtgcagaag atcacgggag gtgtgggact ggttgttgct gttgccgcac 8580
tgattctaat cgtggtgcta tgcgtgtcgt tcagcaggca ctaacttgac aattaagtat 8640
gaaggtatat gtgtccccta agagacacac tgtacatagc aaataatcta tagatcaaag 8700
ggctacgcaa cccctgaata gtaacaaaat ataaaatcac taaaaattat aaaaacagaa 8760
aaatacataa ataggtatac gtgtccccta agagacacat tgtatgtagg tgataagtat 8820
agatcaaagg gccgaataac ccctgaatag taacaaaata tgaaaatcaa taaaaatcat 8880
aaaatagaaa aaccataaac agaagtagtt caaagggcta taaaacccct gaatagtaac 8940
aaaacataaa attaataaaa atcaaatgaa taccataatt ggcaaacgga agagatgtag 9000
gtacttaagc ttcctaaaag cagccgaact cactttgaga agtaggcata gcataccgaa 9060
ctcttccacg attctccgaa cccacaggga cgtaggagat gttattttgt ttttaatatt 9120
tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 9163
<210> 35
<211> 9636
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 35
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctaacccgct ctatgcatca acgtcagagc acgtcaacgt actcctaacg cgtacggaag 720
gtaaactggt atggaagaca ctttccggcg acccgtggat aaagacgctg cagaacccac 780
cgaaaggaaa cttcaaagca actattaagg agtgggaggt ggagcatgca tcaataatgg 840
cgggcatctg cagtcaccaa atgaccttcg atacattcca aaataaagcc aacgtttgtt 900
gggctaagag cttggtccct atcctcgaaa cagcggggat aaaactaaat gataggcagt 960
ggtctcagat aattcaagcc ttcaaagaag acaaagcata ctcacctgaa gtagccctga 1020
atgaaatatg tacgcgcatg tatggggtgg atctagacag cgggctattt tctaaaccgt 1080
tggtgtctgt gtattacgcg gataaccact gggataatag gcctggaggg aaaatgttcg 1140
gatttaaccc cgaggcagca tccattctag aaagaaagta tccattcaca aaagggaagt 1200
ggaacatcaa caagcagatc tgcgtgacta ccaggaggat agaagacttt aaccctacca 1260
ccaacatcat accggccaac aggagactac cacactcatt agtggccgaa caccgcccag 1320
taaaagggga aagaatggaa tggctggtta acaagataaa cggccaccac gtgctcctgg 1380
tcagtggcta taaccttgca ctgcctacta agagagtcac ttgggtagcg ccgttaggtg 1440
tccgtggagc ggactacaca tacaacctag agttgggtct gccagcaacg cttggtaggt 1500
atgacctagt ggtcataaac atccacacac cttttcgcat acaccattac caacagtgcg 1560
tcgaccacgc aatgaaactg caaatgctcg ggggtgactc attgagactg ctcaaaccgg 1620
gcggctctct attgatcaga gcatatggtt acgcagatag aaccagtgaa cgagtcatct 1680
gcgtattggg acgcaagttt agatcgtcta gagcgttgaa accaccatgt gtcaccagca 1740
acactgagat gtttttccta ttcagcaact ttgacaatgg cagaaggaat ttcacaactc 1800
atgtcatgaa caatcaactg aatgcagcct tcgtaggaca ggtcacccga gcaggatgtg 1860
caccgtcgta ccgggtaaaa cgcatggaca tcgcgaagaa cgatgaagag tgcgtagtca 1920
acgccgctaa ccctcgcggg ttaccgggtg acggtgtttg caaggcagta tacaaaaaat 1980
ggccggagtc ctttaagaac agtgcaacac cagtgggaac cgcaaaaaca gttatgtgcg 2040
gtacgtatcc agtaatccac gctgttggac caaacttctc taattattcg gagtctgaag 2100
gggaccggga attggcagct gcctatcgag aagtcgcaaa ggaagtaact aggctgggag 2160
taaatagtgt agctatacct ctcctctcca caggtgtata ctcaggaggg aaagacaggc 2220
tgacccagtc actgaaccac ctctttacag ccatggactc gacggatgca gacgtggtca 2280
tctactgccg cgacaaagaa tgggagaaga aaatatctga ggccatacag atgcggaccc 2340
aagtagagct gctggatgag cacatctcca tagactgcga tattgttcgc gtgcaccctg 2400
acagcagctt ggcaggcaga aaaggataca gcaccacgga aggcgcactg tactcatatc 2460
tagaagggac ccgttttcat cagacggctg tggatatggc ggagatacat actatgtggc 2520
caaagcaaac agaggccaat gagcaagtct gcctatatgc cctgggggaa agtattgaat 2580
cgatcaggca gaaatgcccg gtggatgatg cagacgcatc atctcccccc aaaactgtcc 2640
cgtgcctttg ccgttacgct atgactccag aacgcgtcac ccggcttcgc atgaaccacg 2700
tcacaagcat aattgtgtgt tcttcgtttc ccctcccaaa gtacaaaata gaaggagtgc 2760
aaaaagtcaa atgctctaag gtaatgctat ttgaccacaa cgtgccatcg cgcgtaagtc 2820
caagggaata tagatcttcc caggagtctg cacaggaggc gagtacaatc acgtcactga 2880
cgcatagtca attcgaccta agcgttgatg gcgagatact gcccgtcccg tcagacctgg 2940
atgctgacgc cccagcccta gaaccagcac tagacgacgg ggcgacacac acgctgccat 3000
ccacaaccgg aaaccttgcg gccgtgtctg attgggtaat gagcaccgta cctgtcgcgc 3060
cgcccagaag aaggcgaggg agaaacctga ctgtgacatg tgacgagaga gaagggaata 3120
taacacccat ggctagcgtc cgattcttta gggcagagct gtgtccggtc gtacaagaaa 3180
cagcggagac gcgtgacaca gcaatgtctc ttcaggcacc accgagtacc gccacggaac 3240
cgaatcatcc gccgatctcc ttcggagcat caagcgagac gttccccatt acatttgggg 3300
acttcaacga aggagaaatc gaaagcttgt cttctgagct actaactttc ggagacttct 3360
taccaggaga agtggatgac ttgacagaca gcgactggtc cacgtgctca gacacggacg 3420
acgagttatg actagacagg gcaggtgggt atatattctc gtcggacacc ggtccaggtc 3480
atttacaaca gaagtcagta cgccagtcag tgctgccggt gaacaccctg gaggaagtcc 3540
acgaggagaa gtgttaccca cctaagctgg atgaagcaaa ggagcaacta ttacttaaga 3600
aactccagga gagtgcatcc atggccaaca gaagcaggta tcagtcgcgc aaagtagaaa 3660
acatgaaagc agcaatcatc cagagactaa agagaggctg tagactatac ttaatgtcag 3720
agaccccaaa agtccctact taccggacta catatccggc gcctgtgtac tcgcctccga 3780
tcaacgtccg attgtccaat cccgagtccg cagtggcagc atgcaatgag ttcttagcta 3840
gaaactatcc aactgtctca tcataccaaa ttaccgacga gtatgatgca tatctagaca 3900
tggtggacgg gtcggagagt tgcctggacc gagcgacatt caatccgtca aaactcagga 3960
gctacccgaa acagcacgct taccacgcgc cctccatcag aagcgctgta ccgtccccat 4020
tccagaacac actacagaat gtactggcag cagccacgaa aagaaactgc aacgtcacac 4080
agatgaggga attacccact ttggactcag cagtattcaa cgtggagtgt ttcaaaaaat 4140
tcgcatgcaa ccaagaatac tgggaagaat ttgctgccag ccctattagg ataacaactg 4200
agaatttagc aacctatgtt actaaactaa aagggccaaa agcagcagcg ctattcgcaa 4260
aaacccataa tctactgcca ctacaggaag taccaatgga taggttcaca gtagatatga 4320
aaagggacgt aaaggtgact cctggtacaa agcatacaga ggaaagacct aaggtgcagg 4380
ttatacaggc ggctgaaccc ttggcgacag catacctatg tgggattcac agagagctgg 4440
ttaggaggct gaacgccgtc ctcctaccca atgtacatac actatttgac atgtctgccg 4500
aggatttcga tgccatcata gccgcacact ttaagccagg agacactgtt ttggaaacgg 4560
acatagcctc ctttgataag agccaagatg attcacttgc gcttactgct ttgatgctgt 4620
tagaggattt aggggtggat cactccctgc tggacttgat agaggctgct ttcggagaga 4680
tttccagctg tcacctaccg acaggtacgc gcttcaagtt cggcgccatg atgaaatcag 4740
gtatgttcct aactctgttc gtcaacacat tgttaaacat caccatcgcc agccgagtgc 4800
tggaagatcg tctgacaaaa tccgcgtgcg cggccttcat cggcgacgac aacataatac 4860
atggagtcgt ctccgatgaa ttgatggcag ccagatgtgc cacttggatg aacatggaag 4920
tgaagatcat agatgcagtt gtatccttga aagcccctta cttttgtgga gggtttatac 4980
tgcacgatac tgtgacagga acagcttgca gagtggcaga cccgctaaaa aggcttttta 5040
aactgggcaa accgctagcg gcaggtgacg aacaagatga agatagaaga cgagcgctgg 5100
ctgacgaagt gatcagatgg caacgaacag ggctaattga tgagctggag aaagcggtat 5160
actctaggta cgaagtgcag ggtatatcag ttgtggtaat gtccatggcc acctttgcaa 5220
gctccagatc caacttcgag aagctcagag gacccgtcat aactttgtac ggcggtccta 5280
aataggtacg cactacagct acctattttg cagaagccga cagcaagtat ctaaacacta 5340
atcagctaca atggagttca tcccaaccca aactttttac aataggaggt accagcctcg 5400
accctggact ccgcgcccta ctatccaagt catcaggccc agaccgcgcc ctcagaggca 5460
agctgggcaa cttgcccagc tgatctcagc agttaataaa ctgacaatgc gcgcggtacc 5520
ccaacagaag ccacgcagga atcggaagaa taagaagcaa aagcaaaaac aacaggcgcc 5580
acaaaacaac acaaatcaaa agaagcagcc acctaaaaag aaaccggctc aaaagaaaaa 5640
gaagccgggc cgcagagaga ggatgtgcat gaaaatcgaa aatgattgta ttttcgaagt 5700
caagcacgaa ggtaaggtaa caggttacgc gtgcctggtg ggggacaaag taatgaaacc 5760
agcacacgta aaggggacca tcgataacgc ggacctggcc aaactggcct ttaagcggtc 5820
atctaagtat gaccttgaat gcgcgcagat acccgtgcac atgaagtccg acgcttcgaa 5880
gttcacccat gagaaaccgg aggggtacta caactggcac cacggagcag tacagtactc 5940
aggaggccgg ttcaccatcc ctacaggtgc tggcaaacca ggggacagcg gcagaccgat 6000
cttcgacaac aagggacgcg tggtggccat agtcttagga ggagctaatg aaggagcccg 6060
tacagccctc tcggtggtga cctggaataa agacattgtc actaaaatca cccccgaggg 6120
ggccgaagag tggagtcttg ccatcccagt tatgtgcctg ttggcaaaca ccacgttccc 6180
ctgctcccag cccccttgca cgccctgctg ctacgaaaag gaaccggagg aaaccctacg 6240
catgcttgag gacaacgtca tgagacctgg gtactatcag ctgctacaag catccttaac 6300
atgttctccc caccgccagc gacgcagcac caaggacaac ttcaatgtct ataaagccac 6360
aagaccatac ttagctcact gtcccgactg tggagaaggg cactcgtgcc atagtcccgt 6420
agcactagaa cgcatcagaa atgaagcgac agacgggacg ctgaaaatcc aggtctcctt 6480
gcaaatcgga ataaagacgg atgacagcca cgattggacc aagctgcgtt atatggacaa 6540
ccacatgcca gcagacgcag agagggcggg gctatttgta agaacatcag caccgtgtac 6600
gattactgga acaatgggac acttcatcct ggcccgatgt ccaaaagggg aaactctgac 6660
ggtgggattc actgacagta ggaagattag tcactcatgt acgcacccat ttcaccacga 6720
ccctcctgtg ataggtcggg aaaaattcca ttcccgaccg cagcacggta aagagctacc 6780
ttgcagcacg tacgtgcaga gcaccgccgc aactaccgag gagatagagg tacacatgcc 6840
cccagacacc cctgatcgca cattaatgtc acaacagtcc ggcaacgtaa agatcacagt 6900
caatggccag acggtgcggt acaagtgtaa ttgcggtggc tcaaatgaag gactaacaac 6960
tacagacaaa gtgattaata actgcaaggt tgatcaatgt catgccgcgg tcaccaatca 7020
caaaaagtgg cagtataact cccctctggt cccgcgtaat gctgaacttg gggaccgaaa 7080
aggaaaaatt cacatcccgt ttccgctggc aaatgtaaca tgcagggtgc ctaaagcaag 7140
gaaccccacc gtgacgtacg ggaaaaacca agtcatcatg ctactgtatc ctgaccaccc 7200
aacactcctg tcctaccgga atatgggaga agaaccaaac tatcaagaag agtgggtgat 7260
gcataagaag gaagtcgtgc taaccgtgcc gactgaaggg ctcgaggtca cgtggggcaa 7320
caacgagccg tataagtatt ggccgcagtt atctacaaac ggtacagccc atggccaccc 7380
gcacgagata attctgtatt attatgagct gtaccccact atgactgtag tagttgtgtc 7440
agtggccacg ttcatactcc tgtcgatggt gggtatggca gcggggatgt gcatgtgtgc 7500
acgacgcaga tgcatcacac cgtatgaact gacaccagga gctaccgtcc ctttcctgct 7560
tagcctaata tgctgcatca gaacagctaa agcggccaca taccaagagg ctgcgatata 7620
cctgtggaac gagcagcaac ctttgttttg gctacaagcc cttattccgc tggcagccct 7680
gattgttcta tgcaactgtc tgagactctt accatgctgc tgtaaaacgt tggctttttt 7740
agccgtaatg agcgtcggtg cccacactgt gagcgcgtac gaacacgtaa cagtgatccc 7800
gaacacggtg ggagtaccgt ataagactct agtcaataga cctggctaca gccccatggt 7860
attggagatg gaactactgt cagtcacttt ggagccaaca ctatcgcttg attacatcac 7920
gtgcgagtac aaaaccgtca tcccgtctcc gtacgtgaag tgctgcggta cagcagagtg 7980
caaggacaaa aacctacctg actacagctg taaggtcttc accggcgtct acccatttat 8040
gtggggcggc gcctactgct tctgcgacgc tgaaaacacg cagttgagcg aagcacacgt 8100
ggagaagtcc gaatcatgca aaacagaatt tgcatcagca tacagggctc ataccgcatc 8160
tgcatcagct aagctccgcg tcctttacca aggaaataac atcactgtaa ctgcctatgc 8220
aaacggcgac catgccgtca cagttaagga cgccaaattc attgtggggc caatgtcttc 8280
agcctggaca cctttcgaca acaaaattgt ggtgtacaaa ggtgacgtct ataacatgga 8340
ctacccgccc tttggcgcag gaagaccagg acaatttggc gatatccaaa gtcgcacacc 8400
tgagagtaaa gacgtctatg ctaatacaca actggtactg cagagaccgg ctgtgggtac 8460
ggtacacgtg ccatactctc aggcaccatc tggctttaag tattggctaa aagaacgcgg 8520
ggcgtcgctg cagcacacag caccatttgg ctgccaaata gcaacaaacc cggtaagagc 8580
ggtgaactgc gccgtaggga acatgcccat ctccatcgac ataccggaag cggccttcac 8640
tagggtcgtc gacgcgccct ctttaacgga catgtcgtgc gaggtaccag cctgcaccca 8700
ttcctcagac tttgggggcg tcgccattat taaatatgca gccagcaaga aaggcaagtg 8760
tgcggtgcat tcgatgacta acgccgtcac tattcgggaa gctgagatag aagttgaagg 8820
gaattctcag ctgcaaatct ctttctcgac ggccttagcc agcgccgaat tccgcgtaca 8880
agtctgttct acacaagtac actgtgcagc cgagtgccac cccccgaagg accacatagt 8940
caactacccg gcgtcacata ccaccctcgg ggtccaggac atctccgcta cggcgatgtc 9000
atgggtgcag aagatcacgg gaggtgtggg actggttgtt gctgttgccg cactgattct 9060
aatcgtggtg ctatgcgtgt cgttcagcag gcactaactt gacaattaag tatgaaggta 9120
tatgtgtccc ctaagagaca cactgtacat agcaaataat ctatagatca aagggctacg 9180
caacccctga atagtaacaa aatataaaat cactaaaaat tataaaaaca gaaaaataca 9240
taaataggta tacgtgtccc ctaagagaca cattgtatgt aggtgataag tatagatcaa 9300
agggccgaat aacccctgaa tagtaacaaa atatgaaaat caataaaaat cataaaatag 9360
aaaaaccata aacagaagta gttcaaaggg ctataaaacc cctgaatagt aacaaaacat 9420
aaaattaata aaaatcaaat gaataccata attggcaaac ggaagagatg taggtactta 9480
agcttcctaa aagcagccga actcactttg agaagtaggc atagcatacc gaactcttcc 9540
acgattctcc gaacccacag ggacgtagga gatgttattt tgtttttaat atttcaaaaa 9600
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 9636
<210> 36
<211> 4235
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 36
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctcgacaaac tgggcagatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgacg gaaggtagac gaggcaagtt gtctattatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctctac ccggaaagcc gcaagctact 840
taagagctgg cacctgccat cggtgttcca tttaaagggc aaactcagct tcacatgccg 900
ctgtgataca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacag ggtatgcggt aacccaccac gcagacggat tcctgatgtg 1020
caagactacc gacacggttg acggcgaaag agtgtcattc tcggtgtgca catacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
tacgaacacc atgaaaaatt atctgcttcc cgtggtcgcc caagccttca gtaagtgggc 1260
aaaggagtgc cggaaagaca tggaagatga aaaactcctg ggggtcagag aaagaacact 1320
gacctgctgc tgtctatggg cattcaagaa gcagaaaaca cacacggtct acaagagacc 1380
tgatacccag tcaattcaga aggttcaggc cgagtttgac agctttgtgg taccgagtct 1440
gtggtcgtcc gggttgtcaa tccctttgag gactagaatc aaatggttgt taagcaaggt 1500
gccaaaaacc gacctgatcc catacagcgg agacgcccga gaagcccggg acgcagaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcgcgaa gccctaccac ctctacaggc 1620
agcacaggaa gatgttcagg tcgaaatcga cgtggaacag cttgaggaca gagcgggcgc 1680
aggaataata gagactccga gaggagctat caaagttact gcccaaccaa cagaccacgt 1740
cgtgggagag tacctggtac tctccccgca gaccgtacta cgtagccaga agctcagtct 1800
gattcacgct ttggcggagc aagtgaagac gtgcacgcac aacggacgag cagggaggta 1860
tgcggtcgaa gcgtacgacg gccgagtcct agtgccctca ggctatgcaa tctcgcctga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtat aacgaaagag agttcgtaaa 1980
cagaaagcta caccatattg cgatgcacgg accagccctg aacaccgacg aagagtcgta 2040
tgagctggtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg atcagagaag 2100
atgctgtaag aaggaagaag ccgcaggact ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatatg aagggctaaa aatccgccct gcctgcccat acaaaattgc 2220
agtcatagga gtcttcggag taccgggatc tggcaagtca gctattatca agaacctagt 2280
taccaggcag gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcaccaccga 2340
cgtgatgaga cagagaggtc tagagatatc tgcacgtacg gttgactcgc tgctcttgaa 2400
tggatgcaac agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgctactt gctttgatcg ccttggtgag accaaggcag aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactata atcacaacat 2580
ctgcacccaa gtgtaccaca aaagtatctc caggcggtgt acactgcctg tgaccgccat 2640
tgtgtcatcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acaagccgat 2700
tgtagtggac actacaggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga tacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt agacaaaaag ttaatgaaaa 2880
cccgctctat gcatcaacgt cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacacttt ccggcgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaagcaacta ttaaggagtg ggaggtggag catgcatcaa taatggcggg 3060
catctgcagt caccaaatga ccttcgatac attccaaaat aaagccaacg tttgttgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
tcagataatt caagccttca aagaagacaa agcatactca cctgaagtag ccctgaatga 3240
aatatgtacg cgcatgtatg gggtggatct agacagcggg ctattttcta aaccgttggt 3300
gtctgtgtat tacgcggata accactggga taataggcct ggagggaaaa tgttcggatt 3360
taaccccgag gcagcatcca ttctagaaag aaagtatcca ttcacaaaag ggaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gactttaacc ctaccaccaa 3480
catcataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacggc caccacgtgc tcctggtcag 3600
tggctataac cttgcactgc ctactaagag agtcacttgg gtagcgccgt taggtgtccg 3660
tggagcggac tacacataca acctagagtt gggtctgcca gcaacgcttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtcga 3780
ccacgcaatg aaactgcaaa tgctcggggg tgactcattg agactgctca aaccgggcgg 3840
ctctctattg atcagagcat atggttacgc agatagaacc agtgaacgag ttagatcaaa 3900
gggccgaata acccctgaat agtaacaaaa tatgaaaatc aataaaaatc ataaaataga 3960
aaaaccataa acagaagtag ttcaaagggc tataaaaccc ctgaatagta acaaaacata 4020
aaattaataa aaatcaaatg aataccataa ttggcaaacg gaagagatgt aggtacttaa 4080
gcttcctaaa agcagccgaa ctcactttga gaagtaggca tagcataccg aactcttcca 4140
cgattctccg aacccacagg gacgtaggag atgttatttt gtttttaata tttcaaaaaa 4200
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 4235
<210> 37
<211> 4032
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 37
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctcgacaaac tgggcagatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgacg gaaggtagac gaggcaagtt gtctattatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctctac ccggaaagcc gcaagctact 840
taagagctgg cacctgccat cggtgttcca tttaaagggc aaactcagct tcacatgccg 900
ctgtgataca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacag ggtatgcggt aacccaccac gcagacggat tcctgatgtg 1020
caagactacc gacacggttg acggcgaaag agtgtcattc tcggtgtgca catacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
tacgaacacc atgaaaaatt atctgcttcc cgtggtcgcc caagccttca gtaagtgggc 1260
aaaggagtgc cggaaagaca tggaagatga aaaactcctg ggggtcagag aaagaacact 1320
gacctgctgc tgtctatggg cattcaagaa gcagaaaaca cacacggtct acaagagacc 1380
tgatacccag tcaattcaga aggttcaggc cgagtttgac agctttgtgg taccgagtct 1440
gtggtcgtcc gggttgtcaa tccctttgag gactagaatc aaatggttgt taagcaaggt 1500
gccaaaaacc gacctgatcc catacagcgg agacgcccga gaagcccggg acgcagaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcgcgaa gccctaccac ctctacaggc 1620
agcacaggaa gatgttcagg tcgaaatcga cgtggaacag cttgaggaca gagcgggcgc 1680
aggaataata gagactccga gaggagctat caaagttact gcccaaccaa cagaccacgt 1740
cgtgggagag tacctggtac tctccccgca gaccgtacta cgtagccaga agctcagtct 1800
gattcacgct ttggcggagc aagtgaagac gtgcacgcac aacggacgag cagggaggta 1860
tgcggtcgaa gcgtacgacg gccgagtcct agtgccctca ggctatgcaa tctcgcctga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtat aacgaaagag agttcgtaaa 1980
cagaaagcta caccatattg cgatgcacgg accagccctg aacaccgacg aagagtcgta 2040
tgagctggtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg atcagagaag 2100
atgctgtaag aaggaagaag ccgcaggact ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatatg aagggctaaa aatccgccct gcctgcccat acaaaattgc 2220
agtcatagga gtcttcggag taccgggatc tggcaagtca gctattatca agaacctagt 2280
taccaggcag gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcaccaccga 2340
cgtgatgaga cagagaggtc tagagatatc tgcacgtacg gttgactcgc tgctcttgaa 2400
tggatgcaac agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgctactt gctttgatcg ccttggtgag accaaggcag aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactata atcacaacat 2580
ctgcacccaa gtgtaccaca aaagtatctc caggcggtgt acactgcctg tgaccgccat 2640
tgtgtcatcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acaagccgat 2700
tgtagtggac actacaggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga tacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt agacaaaaag ttaatgaaaa 2880
cccgctctat gcatcaacgt cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacacttt ccggcgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaagcaacta ttaaggagtg ggaggtggag catgcatcaa taatggcggg 3060
catctgcagt caccaaatga ccttcgatac attccaaaat aaagccaacg tttgttgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
tcagataatt caagccttca aagaagacaa agcatactca cctgaagtag ccctgaatga 3240
aatatgtacg cgcatgtatg gggtggatct agacagcggg ctattttcta aaccgttggt 3300
gtctgtgtat tacgcggata accactggga taataggcct ggagggaaaa tgttcggatt 3360
taaccccgag gcagcatcca ttctagaaag aaagtatcca ttcacaaaag ggaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gactttaacc ctaccaccaa 3480
catcataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacggc caccacgtgc tcctggtcag 3600
tggctataac cttgcactgc ctactaagag agtcacttgg gtagcgccgt taggtgtccg 3660
tggagcggac tacacataca acctagagtt gggtctgcca gcaacgcttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtcga 3780
ccacgcaatg aaactgcaaa tgctcggggg tgactcattg agactgctca aaccgggcgg 3840
ctctctattg gcaaacggaa gagatgtagg tacttaagct tcctaaaagc agccgaactc 3900
actttgagaa gtaggcatag cataccgaac tcttccacga ttctccgaac ccacagggac 3960
gtaggagatg ttattttgtt tttaatattt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4020
aaaaaaaaaa aa 4032
<210> 38
<211> 8753
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 38
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctcgacaaac tgggcagatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgacg gaaggtagac gaggcaagtt gtctattatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctctac ccggaaagcc gcaagctact 840
taagagctgg cacctgccat cggtgttcca tttaaagggc aaactcagct tcacatgccg 900
ctgtgataca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacag ggtatgcggt aacccaccac gcagacggat tcctgatgtg 1020
caagactacc gacacggttg acggcgaaag agtgtcattc tcggtgtgca catacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
tacgaacacc atgaaaaatt atctgcttcc cgtggtcgcc caagccttca gtaagtgggc 1260
aaaggagtgc cggaaagaca tggaagatga aaaactcctg ggggtcagag aaagaacact 1320
gacctgctgc tgtctatggg cattcaagaa gcagaaaaca cacacggtct acaagagacc 1380
tgatacccag tcaattcaga aggttcaggc cgagtttgac agctttgtgg taccgagtct 1440
gtggtcgtcc gggttgtcaa tccctttgag gactagaatc aaatggttgt taagcaaggt 1500
gccaaaaacc gacctgatcc catacagcgg agacgcccga gaagcccggg acgcagaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcgcgaa gccctaccac ctctacaggc 1620
agcacaggaa gatgttcagg tcgaaatcga cgtggaacag cttgaggaca gagcgggcgc 1680
aggaataata gagactccga gaggagctat caaagttact gcccaaccaa cagaccacgt 1740
cgtgggagag tacctggtac tctccccgca gaccgtacta cgtagccaga agctcagtct 1800
gattcacgct ttggcggagc aagtgaagac gtgcacgcac aacggacgag cagggaggta 1860
tgcggtcgaa gcgtacgacg gccgagtcct agtgccctca ggctatgcaa tctcgcctga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtat aacgaaagag agttcgtaaa 1980
cagaaagcta caccatattg cgatgcacgg accagccctg aacaccgacg aagagtcgta 2040
tgagctggtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg atcagagaag 2100
atgctgtaag aaggaagaag ccgcaggact ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatatg aagggctaaa aatccgccct gcctgcccat acaaaattgc 2220
agtcatagga gtcttcggag taccgggatc tggcaagtca gctattatca agaacctagt 2280
taccaggcag gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcaccaccga 2340
cgtgatgaga cagagaggtc tagagatatc tgcacgtacg gttgactcgc tgctcttgaa 2400
tggatgcaac agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgctactt gctttgatcg ccttggtgag accaaggcag aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactata atcacaacat 2580
ctgcacccaa gtgtaccaca aaagtatctc caggcggtgt acactgcctg tgaccgccat 2640
tgtgtcatcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acaagccgat 2700
tgtagtggac actacaggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga tacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt agacaaaaag ttaatgaaaa 2880
cccgctctat gcatcaacgt cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacacttt ccggcgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaagcaacta ttaaggagtg ggaggtggag catgcatcaa taatggcggg 3060
catctgcagt caccaaatga ccttcgatac attccaaaat aaagccaacg tttgttgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
tcagataatt caagccttca aagaagacaa agcatactca cctgaagtag ccctgaatga 3240
aatatgtacg cgcatgtatg gggtggatct agacagcggg ctattttcta aaccgttggt 3300
gtctgtgtat tacgcggata accactggga taataggcct ggagggaaaa tgttcggatt 3360
taaccccgag gcagcatcca ttctagaaag aaagtatcca ttcacaaaag ggaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gactttaacc ctaccaccaa 3480
catcataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacggc caccacgtgc tcctggtcag 3600
tggctataac cttgcactgc ctactaagag agtcacttgg gtagcgccgt taggtgtccg 3660
tggagcggac tacacataca acctagagtt gggtctgcca gcaacgcttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtcga 3780
ccacgcaatg aaactgcaaa tgctcggggg tgactcattg agactgctca aaccgggcgg 3840
ctctctattg atcagagcat atggttacgc agatagaacc agtgaacgag tcatctgcgt 3900
attgggacgc aagtttagat cgtctagagc gttgaaacca ccatgtgtca ccagcaacac 3960
tgagatgttt ttcctattca gcaactttga caatggcaga aggaatttca caactcatgt 4020
catgaacaat caactgaatg cagccttcgt aggacaggtc acccgagcag gatgtgcacc 4080
gtcgtaccgg gtaaaacgca tggacatcgc gaagaacgat gaagagtgcg tagtcaacgc 4140
cgctaaccct cgcgggttac cgggtgacgg tgtttgcaag gcagtataca aaaaatggcc 4200
ggagtccttt aagaacagtg caacaccagt gggaaccgca aaaacagtta tgtgcggtac 4260
gtatccagta atccacgctg ttggaccaaa cttctctaat tattcggagt ctgaagggga 4320
ccgggaattg gcagctgcct atcgagaagt cgcaaaggaa gtaactaggc tgggagtaaa 4380
tagtgtagct atacctctcc tctccacagg tgtatactca ggagggaaag acaggctgac 4440
ccagtcactg aaccacctct ttacagccat ggactcgacg gatgcagacg tggtcatcta 4500
ctgccgcgac aaagaatggg agaagaaaat atctgaggcc atacagatgc ggacccaagt 4560
agagctgctg gatgagcaca tctccataga ctgcgatatt gttcgcgtgc accctgacag 4620
cagcttggca ggcagaaaag gatacagcac cacggaaggc gcactgtact catatctaga 4680
agggacccgt tttcatcaga cggctgtgga tatggcggag atacatacta tgtggccaaa 4740
gcaaacagag gccaatgagc aagtctgcct atatgccctg ggggaaagta ttgaatcgat 4800
caggcagaaa tgcccggtgg atgatgcaga cgcatcatct ccccccaaaa ctgtcccgtg 4860
cctttgccgt tacgctatga ctccagaacg cgtcacccgg cttcgcatga accacgtcac 4920
aagcataatt gtgtgttctt cgtttcccct cccaaagtac aaaatagaag gagtgcaaaa 4980
agtcaaatgc tctaaggtaa tgctatttga ccacaacgtg ccatcgcgcg taagtccaag 5040
ggaatataga tcttcccagg agtctgcaca ggaggcgagt acaatcacgt cactgacgca 5100
tagtcaattc gacctaagcg ttgatggcga gatactgccc gtcccgtcag acctggatgc 5160
tgacgcccca gccctagaac cagcactaga cgacggggcg acacacacgc tgccatccac 5220
aaccggaaac cttgcggccg tgtctgattg ggtaatgagc accgtacctg tcgcgccgcc 5280
cagaagaagg cgagggagaa acctgactgt gacatgtgac gagagagaag ggaatataac 5340
acccatggct agcgtccgat tctttagggc agagctgtgt ccggtcgtac aagaaacagc 5400
ggagacgcgt gacacagcaa tgtctcttca ggcaccaccg agtaccgcca cggaaccgaa 5460
tcatccgccg atctccttcg gagcatcaag cgagacgttc cccattacat ttggggactt 5520
caacgaagga gaaatcgaaa gcttgtcttc tgagctacta actttcggag acttcttacc 5580
aggagaagtg gatgacttga cagacagcga ctggtccacg tgctcagaca cggacgacga 5640
gttatgacta gacagggcag gtgggtatat attctcgtcg gacaccggtc caggtcattt 5700
acaacagaag tcagtacgcc agtcagtgct gccggtgaac accctggagg aagtccacga 5760
ggagaagtgt tacccaccta agctggatga agcaaaggag caactattac ttaagaaact 5820
ccaggagagt gcatccatgg ccaacagaag caggtatcag tcgcgcaaag tagaaaacat 5880
gaaagcagca atcatccaga gactaaagag aggctgtaga ctatacttaa tgtcagagac 5940
cccaaaagtc cctacttacc ggactacata tccggcgcct gtgtactcgc ctccgatcaa 6000
cgtccgattg tccaatcccg agtccgcagt ggcagcatgc aatgagttct tagctagaaa 6060
ctatccaact gtctcatcat accaaattac cgacgagtat gatgcatatc tagacatggt 6120
ggacgggtcg gagagttgcc tggaccgagc gacattcaat ccgtcaaaac tcaggagcta 6180
cccgaaacag cacgcttacc acgcgccctc catcagaagc gctgtaccgt ccccattcca 6240
gaacacacta cagaatgtac tggcagcagc cacgaaaaga aactgcaacg tcacacagat 6300
gagggaatta cccactttgg actcagcagt attcaacgtg gagtgtttca aaaaattcgc 6360
atgcaaccaa gaatactggg aagaatttgc tgccagccct attaggataa caactgagaa 6420
tttagcaacc tatgttacta aactaaaagg gccaaaagca gcagcgctat tcgcaaaaac 6480
ccataatcta ctgccactac aggaagtacc aatggatagg ttcacagtag atatgaaaag 6540
ggacgtaaag gtgactcctg gtacaaagca tacagaggaa agacctaagg tgcaggttat 6600
acaggcggct gaacccttgg cgacagcata cctatgtggg attcacagag agctggttag 6660
gaggctgaac gccgtcctcc tacccaatgt acatacacta tttgacatgt ctgccgagga 6720
tttcgatgcc atcatagccg cacactttaa gccaggagac actgttttgg aaacggacat 6780
agcctccttt gataagagcc aagatgattc acttgcgctt actgctttga tgctgttaga 6840
ggatttaggg gtggatcact ccctgctgga cttgatagag gctgctttcg gagagatttc 6900
cagctgtcac ctaccgacag gtacgcgctt caagttcggc gccatgatga aatcaggtat 6960
gttcctaact ctgttcgtca acacattgtt aaacatcacc atcgccagcc gagtgctgga 7020
agatcgtctg acaaaatccg cgtgcgcggc cttcatcggc gacgacaaca taatacatgg 7080
agtcgtctcc gatgaattga tggcagccag atgtgccact tggatgaaca tggaagtgaa 7140
gatcatagat gcagttgtat ccttgaaagc cccttacttt tgtggagggt ttatactgca 7200
cgatactgtg acaggaacag cttgcagagt ggcagacccg ctaaaaaggc tttttaaact 7260
gggcaaaccg ctagcggcag gtgacgaaca agatgaagat agaagacgag cgctggctga 7320
cgaagtgatc agatggcaac gaacagggct aattgatgag ctggagaaag cggtatactc 7380
taggtacgaa gtgcagggta tatcagttgt ggtaatgtcc atggccacct ttgcaagctc 7440
cagatccaac ttcgagaagc tcagaggacc cgtcataact ttgtacggcg gtcctaaata 7500
ggtacgcact acagctacct attttgcaga agccgacagc aagtatctaa acactaatca 7560
gctacaatgg agttcatccc aacccaaact ttttacaata ggaggtacca gcctcgaccc 7620
tggactccgc gccctactat ccaagtcatc aggcccagac cgcgccctca gaggcaagct 7680
gggcaacttg cccagctgat ctcagcagtt aataaactga caatgcgcgc ggtaccccaa 7740
cagaagccac gcaggaatcg gaagaataag aagcaaaagc aaaaacaaca ggcgccacaa 7800
aacaacacaa atcaaaagaa gcagccacct aaaaagaaac cggctcaaaa gaaaaagaag 7860
ccgggccgca gagagaggat gtgcatgaaa atcgaaaatg attgtatttt cgaagtcaag 7920
cacgaaggta aggtaacagg ttacgcgtgc ctggtggggg acaaagtaat gaaaccagca 7980
cacgtaaagg ggaccatcga taacgcggac ctggccaaac tggcctttaa gcggtcatct 8040
aagtatgacc ttgaatgcgc gcagataccc gtgcacatga agtccgacgc ttcgaagttc 8100
acccatgaga aaccggaggg gtactacaac tggcaccacg gagcagtaca gtactcagga 8160
ggccggttca ccatccctac aggtgctggc aaaccagggg acagcggcag accgatcttc 8220
gacaacaagg gacgcgtggt ggccatagtc ttaggaggag ctaatgaagg agcccgtaca 8280
gccctctcgg tggtgacctg gaataaagac attgtcacta aaatcacccc cgagggggcc 8340
gaagagtgga gtcttgccat cccagttatg tgcctgttgg caaacaccac gttcccctgc 8400
tcccagcccc cttgcacgcc ctgctgctac gaaaaggaac cggaggaaac cctacgcatg 8460
cttgaggaca acgtcatgag acctgggtac tatcgtagtt caaagggcta taaaacccct 8520
gaatagtaac aaaacataaa attaataaaa atcaaatgaa taccataatt ggcaaacgga 8580
agagatgtag gtacttaagc ttcctaaaag cagccgaact cactttgaga agtaggcata 8640
gcataccgaa ctcttccacg attctccgaa cccacaggga cgtaggagat gttattttgt 8700
ttttaatatt tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 8753
<210> 39
<211> 3912
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 39
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg atcctgtgta cgtggacata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa ccaaggcagg tcacaccgaa 180
tgaccatgct aatgctagag cgttctcgca tctagctata aaactaatag agcaggaaat 240
tgaccccgac tcaaccatcc tggatatcgg cagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgtct gcccgatgcg cagtgcggaa gatcccgaga gactcgccaa 360
ttatgcgaga aagctagcat ctgccgcagg aaaagtcctg gacagaaaca tctctggaaa 420
gatcggggac ttacaagcag taatggccgt gccagacacg gagacgccaa cattctgctt 480
acacacagac gtctcatgta gacagagagc agacgtcgct atataccaag acgtctatgc 540
tgtacacgca cccacgtcgc tataccacca ggcgattaaa ggggtccgag tggcgtactg 600
ggttgggttc gacacaaccc cgttcatgta caatgccatg gcgggtgcct acccctcata 660
ctcgacaaac tgggcagatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgacg gaaggtagac gaggcaagtt gtctattatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctctac ccggaaagcc gcaagctact 840
taagagctgg cacctgccat cggtgttcca tttaaagggc aaactcagct tcacatgccg 900
ctgtgataca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacag ggtatgcggt aacccaccac gcagacggat tcctgatgtg 1020
caagactacc gacacggttg acggcgaaag agtgtcattc tcggtgtgca catacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
tacgaacacc atgaaaaatt atctgcttcc cgtggtcgcc caagccttca gtaagtgggc 1260
aaaggagtgc cggaaagaca tggaagatga aaaactcctg ggggtcagag aaagaacact 1320
gacctgctgc tgtctatggg cattcaagaa gcagaaaaca cacacggtct acaagagacc 1380
tgatacccag tcaattcaga aggttcaggc cgagtttgac agctttgtgg taccgagtct 1440
gtggtcgtcc gggttgtcaa tccctttgag gactagaatc aaatggttgt taagcaaggt 1500
gccaaaaacc gacctgatcc catacagcgg agacgcccga gaagcccggg acgcagaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcgcgaa gccctaccac ctctacaggc 1620
agcacaggaa gatgttcagg tcgaaatcga cgtggaacag cttgaggaca gagcgggcgc 1680
aggaataata gagactccga gaggagctat caaagttact gcccaaccaa cagaccacgt 1740
cgtgggagag tacctggtac tctccccgca gaccgtacta cgtagccaga agctcagtct 1800
gattcacgct ttggcggagc aagtgaagac gtgcacgcac aacggacgag cagggaggta 1860
tgcggtcgaa gcgtacgacg gccgagtcct agtgccctca ggctatgcaa tctcgcctga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtat aacgaaagag agttcgtaaa 1980
cagaaagcta caccatattg cgatgcacgg accagccctg aacaccgacg aagagtcgta 2040
tgagctggtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg atcagagaag 2100
atgctgtaag aaggaagaag ccgcaggact ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatatg aagggctaaa aatccgccct gcctgcccat acaaaattgc 2220
agtcatagga gtcttcggag taccgggatc tggcaagtca gctattatca agaacctagt 2280
taccaggcag gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcaccaccga 2340
cgtgatgaga cagagaggtc tagagatatc tgcacgtacg gttgactcgc tgctcttgaa 2400
tggatgcaac agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgctactt gctttgatcg ccttggtgag accaaggcag aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactata atcacaacat 2580
ctgcacccaa gtgtaccaca aaagtatctc caggcggtgt acactgcctg tgaccgccat 2640
tgtgtcatcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acaagccgat 2700
tgtagtggac actacaggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga tacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt agacaaaaag ttaatgaaaa 2880
cccgctctat gcatcaacgt cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacacttt ccggcgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaagcaacta ttaaggagtg ggaggtggag catgcatcaa taatggcggg 3060
catctgcagt caccaaatga ccttcgatac attccaaaat aaagccaacg tttgttgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
tcagataatt caagccttca aagaagacaa agcatactca cctgaagtag ccctgaatga 3240
aatatgtacg cgcatgtatg gggtggatct agacagcggg ctattttcta aaccgttggt 3300
gtctgtgtat tacgcggata accactggga taataggcct ggagggaaaa tgttcggatt 3360
taaccccgag gcagcatcca ttctagaaag aaagtatcca ttcacaaaag ggaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gactttaacc ctaccaccaa 3480
catcataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gatcaaaggg ccgaataacc cctgaatagt 3600
aacaaaatat gaaaatcaat aaaaatcata aaatagaaaa accataaaca gaagtagttc 3660
aaagggctat aaaacccctg aatagtaaca aaacataaaa ttaataaaaa tcaaatgaat 3720
accataattg gcaaacggaa gagatgtagg tacttaagct tcctaaaagc agccgaactc 3780
actttgagaa gtaggcatag cataccgaac tcttccacga ttctccgaac ccacagggac 3840
gtaggagatg ttattttgtt tttaatattt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3900
aaaaaaaaaa aa 3912
<210> 40
<211> 9541
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 40
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacgagctt ggtccctatc ctcgaaacag cggggataaa actaaatgat 480
aggcagtggt cccagataat tcaagctttc aaagaagaca aagcatactc acccgaagta 540
gccctgaatg aaatatgcac gcgcatgtat ggggtggatc tagacagcgg gctattctct 600
aaaccgttgg tatctgtgta ttacgcggat aaccactggg ataataggcc gggaggaaag 660
atgttcggat tcaaccctga ggcagcgtcc attctagaaa gaaagtaccc gtttacaaaa 720
ggaaagtgga acatcaacaa gcagatctgc gtgactacca ggaggataga agacttcaac 780
cctaccacca acattatacc ggccaacagg agactaccac actcattagt ggccgaacac 840
cgcccagtaa aaggggaaag aatggaatgg ctggttaaca agataaacgg acatcatgtg 900
ctcctggtta gcggctataa ccttgcactg cctactaaga gagtcacctg ggtagcgcca 960
ctaggtgtcc gcggagcgga ctatacatac aacctagagc tgggtctacc ggcaacactt 1020
ggtaggtatg acctagtggt cataaacatc cacacacctt ttcgcataca ccattaccaa 1080
cagtgcgtag atcacgcaat gaaactgcaa atgctaggag gtgactcact gagactgctc 1140
aaaccgggtg gctctctatt gatcagagca tacggttacg cagatagaac cagtgaacga 1200
gtaatctgcg tactgggacg taagtttaga tcgtccagag cattgaaacc accatgtatc 1260
accagtaata ctgagatgtt cttcctattt agcagttttg acaatggcag aaggaatttt 1320
acaacgcatg ttatgaacaa tcaactgaac gcagcctttg taggacaggc cacccgagca 1380
ggatgtgcac catcgtaccg ggtaaagcgc atggacatcg cgaagaacga tgaagagtgc 1440
gtggtcaacg ccgccaaccc tcgcgggtta ccgggtgacg gtgtttgcaa ggcagtatat 1500
aaaaaatggc cggagtcctt taaaaatagt gcaacaccag taggaaccgc aaaaacagtt 1560
atgtgcggta catatccagt aatccatgcc gtaggaccaa acttctcaaa ttacacggag 1620
tccgaagggg accgggaatt ggcggctgcc tatcgagaag tcgcaaagga agtaactaga 1680
ctgggagtaa atagcgtagc tatacctctc ctctccacag gtgtatactc aggagggaaa 1740
gacaggctaa cccagtcact gaaccacctc tttacagcca tggactcgac ggatgcagac 1800
gtggtcatct actgccgaga caaggaatgg gagaagaaaa tatctgaggc catacagatg 1860
cggacccaag tggagctgct ggatgagcac atctccatag actgcgatgt cattcgcgtg 1920
caccctgaca gtagtttggc aggtagaaaa ggatacagca ccacggaagg cgcactgtat 1980
tcatatctag aagggacacg ttttcaccag acggcagtgg atgtggcaga gatacatact 2040
atgtggccaa agcaaataga ggccaatgag caagtctgcc tatatgccct gggggaaagt 2100
attgagtcaa tcaggcagaa atgcccggtg gatgatgcag atgcatcatc tcccccgaaa 2160
accgtcccgt gcctttgccg ttatgccatg actcctgaac gcgtcacccg acttcgcatg 2220
aaccatgtca caaatataat tgtgtgttct tcatttcccc ttccaaagta caagatagaa 2280
ggagtgcaaa aagtcaaatg ctccaaggta atgttatttg atcacaatgt gccatcgcgc 2340
gtaagtccaa gggaatacag atcttcccag gagtctgtac gggaagtgag tatgacaacg 2400
tcattgacgc atagtcagtt tgatctaagc gccgatggcg agacactgcc cgtcccgtca 2460
gacctggatg ctgacgcccc agccctagaa ccggccctag acgacggggc gatacatacg 2520
accggaaacc ttgcggccgt gtctgactgg gtaatgagca ccgtacccgt cgcgccgcct 2580
agaagaagga gagggagaaa cctgaccgtg atatgtgacg agagagaagg gaatataaca 2640
cccatggcta gcgtccgatt ctttagagca gagcagtgtc cgaccgtaca agaaacagcg 2700
gagacgcgtg acacagctat ttcctttcgg gcaccgccaa gtatcaccgt ggaactgagc 2760
catccaccga tctccttcgg agcaccaagc gagacgttcc ccatcacatt tggggacttc 2820
aacgatggag aaatcgaaag cttgtcttct gagctactaa ctttcggaga cttcctaccc 2880
ggtgaagtgg atgatttgac agatagcgac tggtccacgt gctcagacac ggacgacgag 2940
ttatgactag acagggcagg tgggtatata ttctcgtcgg acaccggtcc aggccattta 3000
caacagaagt cggtacgcca gtcagtgctg ccggtaaaca ccctggagga agttcacgag 3060
gagaagtgtt acccacctaa gctggatgaa ttaaaggagc aactactact taagaaactc 3120
caggagagtg cgtccacggc caatagaagc aggtatcaat cacgcaaagt ggaaaatatg 3180
aaagcaacaa tcatccagag actaaagaga ggctgtaaac tgtatttaat ggcagagacc 3240
ccgaaagtcc cgacttatcg gaccgtatac ccggcgcctg tgtactcgcc tccgatcaac 3300
gtccgattgt ccaatcccga gtccgcagtg gcagcatgta atgagttctt agctagaaac 3360
tacccaactg tttcatcata ccaaatcacc gatgagtatg atgcatatct agacatggtg 3420
gacgggtcgg agagttgctt ggaccgagcg acattcaatc cgtcaaaact taggagctac 3480
ccgaaacaac atgcttatca cgcgccctct atcagaagcg ctgtaccttc cccattccag 3540
aacacactac agaatgtact ggcagcagcc acgaaaagga actgcaacgt cacacagatg 3600
agggaattac ccactttgga ctcagcagta ttcaacgtgg agtgttttaa aaaattcgca 3660
tgcaaccgag aatactggga agaatttgct gccagcccta tcaggataac gactgagaat 3720
ctaacaacct atgtcactaa attaaagggg ccaaaagcag cagcgttgct tgcaagaacc 3780
cataatctgc tgccgctgca ggatgtacca atggataggt tcacagtaga tatgaaaagg 3840
gacgtgaagg taactcctgg cacaaagcat acagaggaaa ggcctaaggt gcaggttata 3900
caggcggctg aacccttggc aacagcgtac ctatgtggaa ttcacagaga attggttagg 3960
agattgaacg ccgtcctcct acccaacgtg catacactat ttgacatgtc tgccgaggac 4020
ttcgatgcca ttatagccgc acactttaag ccaggagacg ccgttttaga aacggacata 4080
gcctcctttg ataagagcca ggatgattca cttgcgctta ccgccttaat gctgttagaa 4140
gatttgggag tggatcactc cttgttggac ctgatagagg ctgcttttgg agagatttcc 4200
agctgtcacc tgccgacagg tacgcgcttc aagttcggcg ctatgatgaa atccggtatg 4260
ttcctaactc tgttcgtcaa cacattgtta aatatcacca tcgctagccg ggtgttggaa 4320
gatcgtctga caaaatctgc atgcgcggcc ttcatcggcg acgacaacat aatacatggt 4380
gtcgtctccg atgaattgat ggcagccaga tgcgctactt ggatgaacat ggaagtgaag 4440
atcatagatg cagttgtatc ccagaaagct ccctactttt gtggagggtt tatactgcat 4500
gatactgtga caggaacagc ttgcagggtg gcggacccgc taaaaaggtt atttaaactg 4560
ggcaaaccgt tagcggcagg tgacgaacaa gacgaagaca gaaggcgggc gctggctgat 4620
gaagtaatca gatggcaacg aacagggcta atagatgagc tggagaaagc ggtgtactct 4680
aggtacgaag tgcagggtat atcagttgct gtaatgtcca tggccacctt tgcaagctcc 4740
agatccaact tcgagaagct cagaggaccc gtcataacct tgtacggcgg tcctaaatag 4800
gtacgcacta cagctaccta ttttgcaaaa gccgacagca ggtacctaaa taccaatcag 4860
ccataatgga gtttatccca acccaaactt tctacaatag gaggtaccag cctcgacctt 4920
ggactccgcg ccctactatc caagtcatca gacccagacc gcgtccgcaa aggaaggccg 4980
ggcaacttgc ccagctgatc tcagcagtta ataaactgac aatgcgcgtg gtacctcaac 5040
agaagccgcg caagaatcgg aagaataaga agcaaaagca aaagcagcag gcgccacgaa 5100
acaatacgaa tcaaaagaag cagcccccca aaaagaaacc ggttcaaaag aaaaagaagc 5160
cgggccgcag agagagaatg tgcatgaaaa tcgaaaatga ttgcatcttc gaagtcaagc 5220
atgaaggtaa ggtaacaggt tacgcgtgct tggtagggga caaagtaatg aagccagcac 5280
acgtaaaggg gaccatcgat aacgcggacc tggccaaatt ggccttcaag cggtcatcta 5340
agtacgacct tgaatgcgcg cagatacccg tgcacatgaa gtccgacgct tcgaagttca 5400
cccatgagaa accggagggg tactacaact ggcaccacgg agcagtacag tactcaggag 5460
gccgattcac catccctaca ggtgcgggca aaccagggga tagtggtaga ccgatcttcg 5520
acaacaaggg gcgcgtggtg gccatagttt taggaggagc taatgaagga gcccgtacag 5580
ccctctcggt ggtgacctgg aacaaagaca tcgtcacgaa aatcacccct gagggggccg 5640
aagagtggag tctggccatt ccagttatgt gcctgctggc aaataccacg ttcccctgct 5700
cccggccccc ttgcacaccc tgctgctacg aaaaagagcc ggagaaaacc ttgcgcatgc 5760
ttgaagacaa tgtcatgagc cccgggtact atcagctgct acaagcatcc ttaacatgtt 5820
ctccccgacg ccagcggcgc agtattaagg accacttcaa tgtctataaa gccacaagac 5880
cgtacctagc tcactgtccc gactgtggag aagggcactc gtgccatagt cccgtagcgc 5940
tagaacgcat cagaaacgaa gcgacagacg ggacgttgaa aatccaggtt tccttgcaaa 6000
tcggaataaa gacggatgat agccatgatt ggaccaagct gcgttatatg gacaatcaca 6060
tgccagcaga cgcagagcgg gccgggctat ttgtaagaac gtcagcaccg tgcacgatta 6120
ctggaacaat gggacacttc attctggccc gatgtccgaa aggagaaact ctgacggtgg 6180
ggttcactga cggtaggaag atcagtcact catgtacgca cccatttcac catgaccctc 6240
ctgtgatagg ccgggaaaaa ttccattccc gaccgcagca cggtagggaa ctaccttgca 6300
gcacgtacgc gcagagcacc gctgcaactg ccgaggagat agaggtacac atgcccccag 6360
acaccccaga tcgcacatta atgtcacaac agtccggcaa tgtaaagatc acagtcaata 6420
gtcagacggt gcggtacaag tgcaattgtg gtgactcaag tgaaggatta accactacag 6480
ataaagtgat taataactgc aaggtcgatc aatgccatgc cgcggtcacc aatcacaaaa 6540
aatggcagta taattcccct ctggtcccgc gtaatgctga attcggggac cggaaaggaa 6600
aagttcacat tccatttcct ctggcaaatg tgacatgcag ggtgcctaaa gcaagaaacc 6660
ccaccgtgac gtacggaaaa aaccaagtca tcatgttgct gtatcctgac cacccaacgc 6720
tcctgtccta caggaatatg ggagaagaac caaactatca agaagagtgg gtgacgcata 6780
agaaggagat caggttaacc gtgccgactg aggggctcga ggtcacgtgg ggtaacaatg 6840
agccgtacaa gtattggccg cagttatcca caaacggtac agcccacggc cacccgcatg 6900
agataattct gtattattat gagctgtacc caactatgac tgcggtagtt ttgtcagtgg 6960
cctcgttcat actcctgtcg atggtgggtg tggcagtggg gatgtgcatg tgtgcacgac 7020
gcagatgcat tacaccgtac gaactgacac caggagctac cgtccctttc ctgcttagcc 7080
taatatgctg cattagaaca gctaaagcgg ccacatacca ggaggccgcg gtatacctgt 7140
ggaacgagca gcagccttta ttttggatgc aagcccttat tccgctggca gccctgattg 7200
tcctatgtaa ctgtctgaga ctcttaccat gctgttgtaa aatgttgact tttttagccg 7260
tactgagcgt cggtgcccac actgtgagcg cgtacgaaca cgtaacagtg atcccgaaca 7320
cggtgggagt accgtataag actctagtca acagaccggg ctacagcccc atggtattgg 7380
agatggagct tctgtctgtc accttggaac caacgctatc gcttgattac atcacgtgcg 7440
agtataaaac cgttatcccg tctccgtacg tgaaatgctg cggtacagca gagtgtaagg 7500
acaagagcct acctgattac agctgtaagg tcttcaccgg cgtctaccca ttcatgtggg 7560
gcggcgccta ctgcttctgc gacaccgaaa atacgcaatt gagcgaagca catgtggaga 7620
agtccgaatc atgcaaaaca gaatttgcat cagcatacag ggctcatacc gcatccgcat 7680
cagctaagct ccgcgtcctt taccaaggaa ataatatcac tgtggctgct tatgcaaacg 7740
gcgaccatgc cgtcacagtt aaggacgcta aattcatagt ggggccaatg tcttcagcct 7800
ggacaccttt cgacaataaa atcgtggtgt acaaaggcga cgtctacaac atggactacc 7860
cgcccttcgg cgcaggaaga ccaggacaat ttggcgacat ccaaagtcgc acgcctgaga 7920
gcgaagacgt ctatgctaat acacaactgg tactgcagag accgtccgcg ggtacggtgc 7980
acgtgccgta ctctcaggca ccatctggct tcaagtattg gctaaaagaa cgaggggcgt 8040
cgctgcagca cacagcacca tttggctgtc aaatagcaac aaacccggta agagcgatga 8100
actgcgccgt agggaacatg cctatctcca tcgacatacc ggacgcggcc tttaccaggg 8160
tcgtcgacgc gccatcttta acggacatgt cgtgtgaggt atcagcctgc acccattcct 8220
cagactttgg gggcgtagcc atcattaaat atgcagccag taagaaaggc aagtgtgcag 8280
tgcactcgat gactaacgcc gtcactattc gggaagctga aatagaagta gaagggaact 8340
ctcagttgca aatctctttt tcgacggccc tagccagcgc cgaatttcgc gtacaagtct 8400
gttctacaca agtacactgt gcagccgagt gccatccacc gaaagaccat atagtcaatt 8460
acccggcgtc acacaccacc ctcggggtcc aagacatttc cgctacggcg atgtcatggg 8520
tgcagaagat cacgggaggt gtgggactgg ttgtcgctgt tgcagcactg atcctaatcg 8580
tggtgctatg cgtgtcgttt agcaggcact aacttgacaa ctaggtatga aggcatacgc 8640
gtccctaaag agacacaccg catatagcta ggaatcaaca gataagtata gatctaaggg 8700
ctgaacaacc cctgaataac aaaatataaa aatcaacaaa aatcataaaa tagaaaacta 8760
gaaatagaag taggtaagaa ggtatatgtg tcccctaaga gacacaccat atatagctaa 8820
gaatcaatag ataagcatag atcaaagggc tgaacaaccc ctgaataata acaaaatata 8880
aaaaccaata aaaatcataa aatagaaaat caacaaaaat cataaaatag aaaactagaa 8940
atagaagtag gtaagaaggt atatgtgtcc cctaagagac acaccatata tagctaagaa 9000
tcaatagata agcatagatc aaagggctga acaacccctg aataataaca aaatataaaa 9060
accaataaaa atcataaaat agaaaaccac aaatagaagt agttcaaagg gctataaaac 9120
ccctgaatag taacaaaata taaaactaat aaaaatcaaa cgaataccat aattggcaat 9180
cggaagagat gtaggtactt aagcttctta aaagcagccg aactcgcttt gagatgtagg 9240
cgtagcacac cgaactcttc cataattctc cgaacccaca gggacgtagg agatgttcaa 9300
agtgactata aaaccctgaa cagtaataaa atataaaatt aataatgagt accataattg 9360
gcaaatggaa gagacgtagg tactaagctt cttaaaagca gccgaactca ctttgagatg 9420
taggcatagc ataccgaact cttccacaat tctccgtacc catagggacg taggagatgt 9480
tattttgttt ttaatatttc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 9540
a 9541
<210> 41
<211> 10014
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 41
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctaacccact ctatgcatca acatcagagc acgtcaacgt actcctaacg cgtacggaag 720
gtaaactggt atggaagaca ctctctggtg acccgtggat aaagacgctg cagaacccac 780
cgaaaggaaa cttcaaggca actattaagg agtgggaggt ggagcacgca tcgataatgg 840
cgggcatctg cagtcaccaa gtgacctttg acacgttcca aaacaaagcc aacgtttgct 900
gggctaagag cttggtccct atcctcgaaa cagcggggat aaaactaaat gataggcagt 960
ggtcccagat aattcaagct ttcaaagaag acaaagcata ctcacccgaa gtagccctga 1020
atgaaatatg cacgcgcatg tatggggtgg atctagacag cgggctattc tctaaaccgt 1080
tggtatctgt gtattacgcg gataaccact gggataatag gccgggagga aagatgttcg 1140
gattcaaccc tgaggcagcg tccattctag aaagaaagta cccgtttaca aaaggaaagt 1200
ggaacatcaa caagcagatc tgcgtgacta ccaggaggat agaagacttc aaccctacca 1260
ccaacattat accggccaac aggagactac cacactcatt agtggccgaa caccgcccag 1320
taaaagggga aagaatggaa tggctggtta acaagataaa cggacatcat gtgctcctgg 1380
ttagcggcta taaccttgca ctgcctacta agagagtcac ctgggtagcg ccactaggtg 1440
tccgcggagc ggactataca tacaacctag agctgggtct accggcaaca cttggtaggt 1500
atgacctagt ggtcataaac atccacacac cttttcgcat acaccattac caacagtgcg 1560
tagatcacgc aatgaaactg caaatgctag gaggtgactc actgagactg ctcaaaccgg 1620
gtggctctct attgatcaga gcatacggtt acgcagatag aaccagtgaa cgagtaatct 1680
gcgtactggg acgtaagttt agatcgtcca gagcattgaa accaccatgt atcaccagta 1740
atactgagat gttcttccta tttagcagtt ttgacaatgg cagaaggaat tttacaacgc 1800
atgttatgaa caatcaactg aacgcagcct ttgtaggaca ggccacccga gcaggatgtg 1860
caccatcgta ccgggtaaag cgcatggaca tcgcgaagaa cgatgaagag tgcgtggtca 1920
acgccgccaa ccctcgcggg ttaccgggtg acggtgtttg caaggcagta tataaaaaat 1980
ggccggagtc ctttaaaaat agtgcaacac cagtaggaac cgcaaaaaca gttatgtgcg 2040
gtacatatcc agtaatccat gccgtaggac caaacttctc aaattacacg gagtccgaag 2100
gggaccggga attggcggct gcctatcgag aagtcgcaaa ggaagtaact agactgggag 2160
taaatagcgt agctatacct ctcctctcca caggtgtata ctcaggaggg aaagacaggc 2220
taacccagtc actgaaccac ctctttacag ccatggactc gacggatgca gacgtggtca 2280
tctactgccg agacaaggaa tgggagaaga aaatatctga ggccatacag atgcggaccc 2340
aagtggagct gctggatgag cacatctcca tagactgcga tgtcattcgc gtgcaccctg 2400
acagtagttt ggcaggtaga aaaggataca gcaccacgga aggcgcactg tattcatatc 2460
tagaagggac acgttttcac cagacggcag tggatgtggc agagatacat actatgtggc 2520
caaagcaaat agaggccaat gagcaagtct gcctatatgc cctgggggaa agtattgagt 2580
caatcaggca gaaatgcccg gtggatgatg cagatgcatc atctcccccg aaaaccgtcc 2640
cgtgcctttg ccgttatgcc atgactcctg aacgcgtcac ccgacttcgc atgaaccatg 2700
tcacaaatat aattgtgtgt tcttcatttc cccttccaaa gtacaagata gaaggagtgc 2760
aaaaagtcaa atgctccaag gtaatgttat ttgatcacaa tgtgccatcg cgcgtaagtc 2820
caagggaata cagatcttcc caggagtctg tacgggaagt gagtatgaca acgtcattga 2880
cgcatagtca gtttgatcta agcgccgatg gcgagacact gcccgtcccg tcagacctgg 2940
atgctgacgc cccagcccta gaaccggccc tagacgacgg ggcgatacat acgaccggaa 3000
accttgcggc cgtgtctgac tgggtaatga gcaccgtacc cgtcgcgccg cctagaagaa 3060
ggagagggag aaacctgacc gtgatatgtg acgagagaga agggaatata acacccatgg 3120
ctagcgtccg attctttaga gcagagcagt gtccgaccgt acaagaaaca gcggagacgc 3180
gtgacacagc tatttccttt cgggcaccgc caagtatcac cgtggaactg agccatccac 3240
cgatctcctt cggagcacca agcgagacgt tccccatcac atttggggac ttcaacgatg 3300
gagaaatcga aagcttgtct tctgagctac taactttcgg agacttccta cccggtgaag 3360
tggatgattt gacagatagc gactggtcca cgtgctcaga cacggacgac gagttatgac 3420
tagacagggc aggtgggtat atattctcgt cggacaccgg tccaggccat ttacaacaga 3480
agtcggtacg ccagtcagtg ctgccggtaa acaccctgga ggaagttcac gaggagaagt 3540
gttacccacc taagctggat gaattaaagg agcaactact acttaagaaa ctccaggaga 3600
gtgcgtccac ggccaataga agcaggtatc aatcacgcaa agtggaaaat atgaaagcaa 3660
caatcatcca gagactaaag agaggctgta aactgtattt aatggcagag accccgaaag 3720
tcccgactta tcggaccgta tacccggcgc ctgtgtactc gcctccgatc aacgtccgat 3780
tgtccaatcc cgagtccgca gtggcagcat gtaatgagtt cttagctaga aactacccaa 3840
ctgtttcatc ataccaaatc accgatgagt atgatgcata tctagacatg gtggacgggt 3900
cggagagttg cttggaccga gcgacattca atccgtcaaa acttaggagc tacccgaaac 3960
aacatgctta tcacgcgccc tctatcagaa gcgctgtacc ttccccattc cagaacacac 4020
tacagaatgt actggcagca gccacgaaaa ggaactgcaa cgtcacacag atgagggaat 4080
tacccacttt ggactcagca gtattcaacg tggagtgttt taaaaaattc gcatgcaacc 4140
gagaatactg ggaagaattt gctgccagcc ctatcaggat aacgactgag aatctaacaa 4200
cctatgtcac taaattaaag gggccaaaag cagcagcgtt gcttgcaaga acccataatc 4260
tgctgccgct gcaggatgta ccaatggata ggttcacagt agatatgaaa agggacgtga 4320
aggtaactcc tggcacaaag catacagagg aaaggcctaa ggtgcaggtt atacaggcgg 4380
ctgaaccctt ggcaacagcg tacctatgtg gaattcacag agaattggtt aggagattga 4440
acgccgtcct cctacccaac gtgcatacac tatttgacat gtctgccgag gacttcgatg 4500
ccattatagc cgcacacttt aagccaggag acgccgtttt agaaacggac atagcctcct 4560
ttgataagag ccaggatgat tcacttgcgc ttaccgcctt aatgctgtta gaagatttgg 4620
gagtggatca ctccttgttg gacctgatag aggctgcttt tggagagatt tccagctgtc 4680
acctgccgac aggtacgcgc ttcaagttcg gcgctatgat gaaatccggt atgttcctaa 4740
ctctgttcgt caacacattg ttaaatatca ccatcgctag ccgggtgttg gaagatcgtc 4800
tgacaaaatc tgcatgcgcg gccttcatcg gcgacgacaa cataatacat ggtgtcgtct 4860
ccgatgaatt gatggcagcc agatgcgcta cttggatgaa catggaagtg aagatcatag 4920
atgcagttgt atcccagaaa gctccctact tttgtggagg gtttatactg catgatactg 4980
tgacaggaac agcttgcagg gtggcggacc cgctaaaaag gttatttaaa ctgggcaaac 5040
cgttagcggc aggtgacgaa caagacgaag acagaaggcg ggcgctggct gatgaagtaa 5100
tcagatggca acgaacaggg ctaatagatg agctggagaa agcggtgtac tctaggtacg 5160
aagtgcaggg tatatcagtt gctgtaatgt ccatggccac ctttgcaagc tccagatcca 5220
acttcgagaa gctcagagga cccgtcataa ccttgtacgg cggtcctaaa taggtacgca 5280
ctacagctac ctattttgca aaagccgaca gcaggtacct aaataccaat cagccataat 5340
ggagtttatc ccaacccaaa ctttctacaa taggaggtac cagcctcgac cttggactcc 5400
gcgccctact atccaagtca tcagacccag accgcgtccg caaaggaagg ccgggcaact 5460
tgcccagctg atctcagcag ttaataaact gacaatgcgc gtggtacctc aacagaagcc 5520
gcgcaagaat cggaagaata agaagcaaaa gcaaaagcag caggcgccac gaaacaatac 5580
gaatcaaaag aagcagcccc ccaaaaagaa accggttcaa aagaaaaaga agccgggccg 5640
cagagagaga atgtgcatga aaatcgaaaa tgattgcatc ttcgaagtca agcatgaagg 5700
taaggtaaca ggttacgcgt gcttggtagg ggacaaagta atgaagccag cacacgtaaa 5760
ggggaccatc gataacgcgg acctggccaa attggccttc aagcggtcat ctaagtacga 5820
ccttgaatgc gcgcagatac ccgtgcacat gaagtccgac gcttcgaagt tcacccatga 5880
gaaaccggag gggtactaca actggcacca cggagcagta cagtactcag gaggccgatt 5940
caccatccct acaggtgcgg gcaaaccagg ggatagtggt agaccgatct tcgacaacaa 6000
ggggcgcgtg gtggccatag ttttaggagg agctaatgaa ggagcccgta cagccctctc 6060
ggtggtgacc tggaacaaag acatcgtcac gaaaatcacc cctgaggggg ccgaagagtg 6120
gagtctggcc attccagtta tgtgcctgct ggcaaatacc acgttcccct gctcccggcc 6180
cccttgcaca ccctgctgct acgaaaaaga gccggagaaa accttgcgca tgcttgaaga 6240
caatgtcatg agccccgggt actatcagct gctacaagca tccttaacat gttctccccg 6300
acgccagcgg cgcagtatta aggaccactt caatgtctat aaagccacaa gaccgtacct 6360
agctcactgt cccgactgtg gagaagggca ctcgtgccat agtcccgtag cgctagaacg 6420
catcagaaac gaagcgacag acgggacgtt gaaaatccag gtttccttgc aaatcggaat 6480
aaagacggat gatagccatg attggaccaa gctgcgttat atggacaatc acatgccagc 6540
agacgcagag cgggccgggc tatttgtaag aacgtcagca ccgtgcacga ttactggaac 6600
aatgggacac ttcattctgg cccgatgtcc gaaaggagaa actctgacgg tggggttcac 6660
tgacggtagg aagatcagtc actcatgtac gcacccattt caccatgacc ctcctgtgat 6720
aggccgggaa aaattccatt cccgaccgca gcacggtagg gaactacctt gcagcacgta 6780
cgcgcagagc accgctgcaa ctgccgagga gatagaggta cacatgcccc cagacacccc 6840
agatcgcaca ttaatgtcac aacagtccgg caatgtaaag atcacagtca atagtcagac 6900
ggtgcggtac aagtgcaatt gtggtgactc aagtgaagga ttaaccacta cagataaagt 6960
gattaataac tgcaaggtcg atcaatgcca tgccgcggtc accaatcaca aaaaatggca 7020
gtataattcc cctctggtcc cgcgtaatgc tgaattcggg gaccggaaag gaaaagttca 7080
cattccattt cctctggcaa atgtgacatg cagggtgcct aaagcaagaa accccaccgt 7140
gacgtacgga aaaaaccaag tcatcatgtt gctgtatcct gaccacccaa cgctcctgtc 7200
ctacaggaat atgggagaag aaccaaacta tcaagaagag tgggtgacgc ataagaagga 7260
gatcaggtta accgtgccga ctgaggggct cgaggtcacg tggggtaaca atgagccgta 7320
caagtattgg ccgcagttat ccacaaacgg tacagcccac ggccacccgc atgagataat 7380
tctgtattat tatgagctgt acccaactat gactgcggta gttttgtcag tggcctcgtt 7440
catactcctg tcgatggtgg gtgtggcagt ggggatgtgc atgtgtgcac gacgcagatg 7500
cattacaccg tacgaactga caccaggagc taccgtccct ttcctgctta gcctaatatg 7560
ctgcattaga acagctaaag cggccacata ccaggaggcc gcggtatacc tgtggaacga 7620
gcagcagcct ttattttgga tgcaagccct tattccgctg gcagccctga ttgtcctatg 7680
taactgtctg agactcttac catgctgttg taaaatgttg acttttttag ccgtactgag 7740
cgtcggtgcc cacactgtga gcgcgtacga acacgtaaca gtgatcccga acacggtggg 7800
agtaccgtat aagactctag tcaacagacc gggctacagc cccatggtat tggagatgga 7860
gcttctgtct gtcaccttgg aaccaacgct atcgcttgat tacatcacgt gcgagtataa 7920
aaccgttatc ccgtctccgt acgtgaaatg ctgcggtaca gcagagtgta aggacaagag 7980
cctacctgat tacagctgta aggtcttcac cggcgtctac ccattcatgt ggggcggcgc 8040
ctactgcttc tgcgacaccg aaaatacgca attgagcgaa gcacatgtgg agaagtccga 8100
atcatgcaaa acagaatttg catcagcata cagggctcat accgcatccg catcagctaa 8160
gctccgcgtc ctttaccaag gaaataatat cactgtggct gcttatgcaa acggcgacca 8220
tgccgtcaca gttaaggacg ctaaattcat agtggggcca atgtcttcag cctggacacc 8280
tttcgacaat aaaatcgtgg tgtacaaagg cgacgtctac aacatggact acccgccctt 8340
cggcgcagga agaccaggac aatttggcga catccaaagt cgcacgcctg agagcgaaga 8400
cgtctatgct aatacacaac tggtactgca gagaccgtcc gcgggtacgg tgcacgtgcc 8460
gtactctcag gcaccatctg gcttcaagta ttggctaaaa gaacgagggg cgtcgctgca 8520
gcacacagca ccatttggct gtcaaatagc aacaaacccg gtaagagcga tgaactgcgc 8580
cgtagggaac atgcctatct ccatcgacat accggacgcg gcctttacca gggtcgtcga 8640
cgcgccatct ttaacggaca tgtcgtgtga ggtatcagcc tgcacccatt cctcagactt 8700
tgggggcgta gccatcatta aatatgcagc cagtaagaaa ggcaagtgtg cagtgcactc 8760
gatgactaac gccgtcacta ttcgggaagc tgaaatagaa gtagaaggga actctcagtt 8820
gcaaatctct ttttcgacgg ccctagccag cgccgaattt cgcgtacaag tctgttctac 8880
acaagtacac tgtgcagccg agtgccatcc accgaaagac catatagtca attacccggc 8940
gtcacacacc accctcgggg tccaagacat ttccgctacg gcgatgtcat gggtgcagaa 9000
gatcacggga ggtgtgggac tggttgtcgc tgttgcagca ctgatcctaa tcgtggtgct 9060
atgcgtgtcg tttagcaggc actaacttga caactaggta tgaaggcata cgcgtcccta 9120
aagagacaca ccgcatatag ctaggaatca acagataagt atagatctaa gggctgaaca 9180
acccctgaat aacaaaatat aaaaatcaac aaaaatcata aaatagaaaa ctagaaatag 9240
aagtaggtaa gaaggtatat gtgtccccta agagacacac catatatagc taagaatcaa 9300
tagataagca tagatcaaag ggctgaacaa cccctgaata ataacaaaat ataaaaacca 9360
ataaaaatca taaaatagaa aatcaacaaa aatcataaaa tagaaaacta gaaatagaag 9420
taggtaagaa ggtatatgtg tcccctaaga gacacaccat atatagctaa gaatcaatag 9480
ataagcatag atcaaagggc tgaacaaccc ctgaataata acaaaatata aaaaccaata 9540
aaaatcataa aatagaaaac cacaaataga agtagttcaa agggctataa aacccctgaa 9600
tagtaacaaa atataaaact aataaaaatc aaacgaatac cataattggc aatcggaaga 9660
gatgtaggta cttaagcttc ttaaaagcag ccgaactcgc tttgagatgt aggcgtagca 9720
caccgaactc ttccataatt ctccgaaccc acagggacgt aggagatgtt caaagtgact 9780
ataaaaccct gaacagtaat aaaatataaa attaataatg agtaccataa ttggcaaatg 9840
gaagagacgt aggtactaag cttcttaaaa gcagccgaac tcactttgag atgtaggcat 9900
agcataccga actcttccac aattctccgt acccataggg acgtaggaga tgttattttg 9960
tttttaatat ttcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 10014
<210> 42
<211> 4595
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 42
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taagatcaaa 3900
gggctgaaca acccctgaat aataacaaaa tataaaaacc aataaaaatc ataaaataga 3960
aaatcaacaa aaatcataaa atagaaaact agaaatagaa gtaggtaaga aggtatatgt 4020
gtcccctaag agacacacca tatatagcta agaatcaata gataagcata gatcaaaggg 4080
ctgaacaacc cctgaataat aacaaaatat aaaaaccaat aaaaatcata aaatagaaaa 4140
ccacaaatag aagtagttca aagggctata aaacccctga atagtaacaa aatataaaac 4200
taataaaaat caaacgaata ccataattgg caatcggaag agatgtaggt acttaagctt 4260
cttaaaagca gccgaactcg ctttgagatg taggcgtagc acaccgaact cttccataat 4320
tctccgaacc cacagggacg taggagatgt tcaaagtgac tataaaaccc tgaacagtaa 4380
taaaatataa aattaataat gagtaccata attggcaaat ggaagagacg taggtactaa 4440
gcttcttaaa agcagccgaa ctcactttga gatgtaggca tagcataccg aactcttcca 4500
caattctccg tacccatagg gacgtaggag atgttatttt gtttttaata tttcaaaaaa 4560
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 4595
<210> 43
<211> 4418
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 43
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taagatcaaa 3900
gggctgaaca acccctgaat aataacaaaa tataaaaacc aataaaaatc ataaaataga 3960
aaaccacaaa tagaagtagt tcaaagggct ataaaacccc tgaatagtaa caaaatataa 4020
aactaataaa aatcaaacga ataccataat tggcaatcgg aagagatgta ggtacttaag 4080
cttcttaaaa gcagccgaac tcgctttgag atgtaggcgt agcacaccga actcttccat 4140
aattctccga acccacaggg acgtaggaga tgttcaaagt gactataaaa ccctgaacag 4200
taataaaata taaaattaat aatgagtacc ataattggca aatggaagag acgtaggtac 4260
taagcttctt aaaagcagcc gaactcactt tgagatgtag gcatagcata ccgaactctt 4320
ccacaattct ccgtacccat agggacgtag gagatgttat tttgttttta atatttcaaa 4380
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 4418
<210> 44
<211> 10549
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 44
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagaaa attcgccccg cttgtccata taaaattgca 540
gtcataggag tcttcggggt accaggatct ggtaagtcag ccattatcaa gaacctagtt 600
accaggcaag acctggtgac tagcggaaag aaagaaaact gccaagaaat cagcaccgac 660
gtgatgagac agagaggtct agaaatatct gcacgtacgg ttgattcgct gctcttgaat 720
ggatgcaata gaccagtcga cgtgttgtac gtagacgagg cgtttgcgtg ccactctgga 780
acgttacttg ccttgatcgc cttggtgaga ccaagactga aagttgtact ttgtggtgac 840
ccgaagcagt gcggcttctt caatatgatg cagatgaaag tcaactacaa tcataacatc 900
tgcactcaag tgtaccacaa aagtatttcc aggcggtgta cactgcctgt gactgccatt 960
gtgtcgtcgt tgcattacga aggcaaaatg cgcactacga atgagtacaa catgccgatt 1020
gtagtggaca ctacgggctc aacaaaacct gaccctggag acctcgtgtt aacgtgcttc 1080
agagggtggg ttaaacaact gcaaattgac tatcgtggac acgaggtcat gacagcagcc 1140
gcatcccaag ggttaaccag aaaaggagtt tacgcagtta ggcaaaaagt taacgaaaac 1200
ccactctatg catcaacatc agagcacgtc aacgtactcc taacgcgtac ggaaggtaaa 1260
ctggtatgga agacactctc tggtgacccg tggataaaga cgctgcagaa cccaccgaaa 1320
ggaaacttca aggcaactat taaggagtgg gaggtggagc acgcatcgat aatggcgggc 1380
atctgcagtc accaagtgac ctttgacacg ttccaaaaca aagccaacgt ttgctgggct 1440
aagagcttgg tccctatcct cgaaacagcg gggataaaac taaatgatag gcagtggtcc 1500
cagataattc aagctttcaa agaagacaaa gcatactcac ccgaagtagc cctgaatgaa 1560
atatgcacgc gcatgtatgg ggtggatcta gacagcgggc tattctctaa accgttggta 1620
tctgtgtatt acgcggataa ccactgggat aataggccgg gaggaaagat gttcggattc 1680
aaccctgagg cagcgtccat tctagaaaga aagtacccgt ttacaaaagg aaagtggaac 1740
atcaacaagc agatctgcgt gactaccagg aggatagaag acttcaaccc taccaccaac 1800
attataccgg ccaacaggag actaccacac tcattagtgg ccgaacaccg cccagtaaaa 1860
ggggaaagaa tggaatggct ggttaacaag ataaacggac atcatgtgct cctggttagc 1920
ggctataacc ttgcactgcc tactaagaga gtcacctggg tagcgccact aggtgtccgc 1980
ggagcggact atacatacaa cctagagctg ggtctaccgg caacacttgg taggtatgac 2040
ctagtggtca taaacatcca cacacctttt cgcatacacc attaccaaca gtgcgtagat 2100
cacgcaatga aactgcaaat gctaggaggt gactcactga gactgctcaa accgggtggc 2160
tctctattga tcagagcata cggttacgca gatagaacca gtgaacgagt aatctgcgta 2220
ctgggacgta agtttagatc gtccagagca ttgaaaccac catgtatcac cagtaatact 2280
gagatgttct tcctatttag cagttttgac aatggcagaa ggaattttac aacgcatgtt 2340
atgaacaatc aactgaacgc agcctttgta ggacaggcca cccgagcagg atgtgcacca 2400
tcgtaccggg taaagcgcat ggacatcgcg aagaacgatg aagagtgcgt ggtcaacgcc 2460
gccaaccctc gcgggttacc gggtgacggt gtttgcaagg cagtatataa aaaatggccg 2520
gagtccttta aaaatagtgc aacaccagta ggaaccgcaa aaacagttat gtgcggtaca 2580
tatccagtaa tccatgccgt aggaccaaac ttctcaaatt acacggagtc cgaaggggac 2640
cgggaattgg cggctgccta tcgagaagtc gcaaaggaag taactagact gggagtaaat 2700
agcgtagcta tacctctcct ctccacaggt gtatactcag gagggaaaga caggctaacc 2760
cagtcactga accacctctt tacagccatg gactcgacgg atgcagacgt ggtcatctac 2820
tgccgagaca aggaatggga gaagaaaata tctgaggcca tacagatgcg gacccaagtg 2880
gagctgctgg atgagcacat ctccatagac tgcgatgtca ttcgcgtgca ccctgacagt 2940
agtttggcag gtagaaaagg atacagcacc acggaaggcg cactgtattc atatctagaa 3000
gggacacgtt ttcaccagac ggcagtggat gtggcagaga tacatactat gtggccaaag 3060
caaatagagg ccaatgagca agtctgccta tatgccctgg gggaaagtat tgagtcaatc 3120
aggcagaaat gcccggtgga tgatgcagat gcatcatctc ccccgaaaac cgtcccgtgc 3180
ctttgccgtt atgccatgac tcctgaacgc gtcacccgac ttcgcatgaa ccatgtcaca 3240
aatataattg tgtgttcttc atttcccctt ccaaagtaca agatagaagg agtgcaaaaa 3300
gtcaaatgct ccaaggtaat gttatttgat cacaatgtgc catcgcgcgt aagtccaagg 3360
gaatacagat cttcccagga gtctgtacgg gaagtgagta tgacaacgtc attgacgcat 3420
agtcagtttg atctaagcgc cgatggcgag acactgcccg tcccgtcaga cctggatgct 3480
gacgccccag ccctagaacc ggccctagac gacggggcga tacatacgac cggaaacctt 3540
gcggccgtgt ctgactgggt aatgagcacc gtacccgtcg cgccgcctag aagaaggaga 3600
gggagaaacc tgaccgtgat atgtgacgag agagaaggga atataacacc catggctagc 3660
gtccgattct ttagagcaga gcagtgtccg accgtacaag aaacagcgga gacgcgtgac 3720
acagctattt cctttcgggc accgccaagt atcaccgtgg aactgagcca tccaccgatc 3780
tccttcggag caccaagcga gacgttcccc atcacatttg gggacttcaa cgatggagaa 3840
atcgaaagct tgtcttctga gctactaact ttcggagact tcctacccgg tgaagtggat 3900
gatttgacag atagcgactg gtccacgtgc tcagacacgg acgacgagtt atgactagac 3960
agggcaggtg ggtatatatt ctcgtcggac accggtccag gccatttaca acagaagtcg 4020
gtacgccagt cagtgctgcc ggtaaacacc ctggaggaag ttcacgagga gaagtgttac 4080
ccacctaagc tggatgaatt aaaggagcaa ctactactta agaaactcca ggagagtgcg 4140
tccacggcca atagaagcag gtatcaatca cgcaaagtgg aaaatatgaa agcaacaatc 4200
atccagagac taaagagagg ctgtaaactg tatttaatgg cagagacccc gaaagtcccg 4260
acttatcgga ccgtataccc ggcgcctgtg tactcgcctc cgatcaacgt ccgattgtcc 4320
aatcccgagt ccgcagtggc agcatgtaat gagttcttag ctagaaacta cccaactgtt 4380
tcatcatacc aaatcaccga tgagtatgat gcatatctag acatggtgga cgggtcggag 4440
agttgcttgg accgagcgac attcaatccg tcaaaactta ggagctaccc gaaacaacat 4500
gcttatcacg cgccctctat cagaagcgct gtaccttccc cattccagaa cacactacag 4560
aatgtactgg cagcagccac gaaaaggaac tgcaacgtca cacagatgag ggaattaccc 4620
actttggact cagcagtatt caacgtggag tgttttaaaa aattcgcatg caaccgagaa 4680
tactgggaag aatttgctgc cagccctatc aggataacga ctgagaatct aacaacctat 4740
gtcactaaat taaaggggcc aaaagcagca gcgttgcttg caagaaccca taatctgctg 4800
ccgctgcagg atgtaccaat ggataggttc acagtagata tgaaaaggga cgtgaaggta 4860
actcctggca caaagcatac agaggaaagg cctaaggtgc aggttataca ggcggctgaa 4920
cccttggcaa cagcgtacct atgtggaatt cacagagaat tggttaggag attgaacgcc 4980
gtcctcctac ccaacgtgca tacactattt gacatgtctg ccgaggactt cgatgccatt 5040
atagccgcac actttaagcc aggagacgcc gttttagaaa cggacatagc ctcctttgat 5100
aagagccagg atgattcact tgcgcttacc gccttaatgc tgttagaaga tttgggagtg 5160
gatcactcct tgttggacct gatagaggct gcttttggag agatttccag ctgtcacctg 5220
ccgacaggta cgcgcttcaa gttcggcgct atgatgaaat ccggtatgtt cctaactctg 5280
ttcgtcaaca cattgttaaa tatcaccatc gctagccggg tgttggaaga tcgtctgaca 5340
aaatctgcat gcgcggcctt catcggcgac gacaacataa tacatggtgt cgtctccgat 5400
gaattgatgg cagccagatg cgctacttgg atgaacatgg aagtgaagat catagatgca 5460
gttgtatccc agaaagctcc ctacttttgt ggagggttta tactgcatga tactgtgaca 5520
ggaacagctt gcagggtggc ggacccgcta aaaaggttat ttaaactggg caaaccgtta 5580
gcggcaggtg acgaacaaga cgaagacaga aggcgggcgc tggctgatga agtaatcaga 5640
tggcaacgaa cagggctaat agatgagctg gagaaagcgg tgtactctag gtacgaagtg 5700
cagggtatat cagttgctgt aatgtccatg gccacctttg caagctccag atccaacttc 5760
gagaagctca gaggacccgt cataaccttg tacggcggtc ctaaataggt acgcactaca 5820
gctacctatt ttgcaaaagc cgacagcagg tacctaaata ccaatcagcc ataatggagt 5880
ttatcccaac ccaaactttc tacaatagga ggtaccagcc tcgaccttgg actccgcgcc 5940
ctactatcca agtcatcaga cccagaccgc gtccgcaaag gaaggccggg caacttgccc 6000
agctgatctc agcagttaat aaactgacaa tgcgcgtggt acctcaacag aagccgcgca 6060
agaatcggaa gaataagaag caaaagcaaa agcagcaggc gccacgaaac aatacgaatc 6120
aaaagaagca gccccccaaa aagaaaccgg ttcaaaagaa aaagaagccg ggccgcagag 6180
agagaatgtg catgaaaatc gaaaatgatt gcatcttcga agtcaagcat gaaggtaagg 6240
taacaggtta cgcgtgcttg gtaggggaca aagtaatgaa gccagcacac gtaaagggga 6300
ccatcgataa cgcggacctg gccaaattgg ccttcaagcg gtcatctaag tacgaccttg 6360
aatgcgcgca gatacccgtg cacatgaagt ccgacgcttc gaagttcacc catgagaaac 6420
cggaggggta ctacaactgg caccacggag cagtacagta ctcaggaggc cgattcacca 6480
tccctacagg tgcgggcaaa ccaggggata gtggtagacc gatcttcgac aacaaggggc 6540
gcgtggtggc catagtttta ggaggagcta atgaaggagc ccgtacagcc ctctcggtgg 6600
tgacctggaa caaagacatc gtcacgaaaa tcacccctga gggggccgaa gagtggagtc 6660
tggccattcc agttatgtgc ctgctggcaa ataccacgtt cccctgctcc cggccccctt 6720
gcacaccctg ctgctacgaa aaagagccgg agaaaacctt gcgcatgctt gaagacaatg 6780
tcatgagccc cgggtactat cagctgctac aagcatcctt aacatgttct ccccgacgcc 6840
agcggcgcag tattaaggac cacttcaatg tctataaagc cacaagaccg tacctagctc 6900
actgtcccga ctgtggagaa gggcactcgt gccatagtcc cgtagcgcta gaacgcatca 6960
gaaacgaagc gacagacggg acgttgaaaa tccaggtttc cttgcaaatc ggaataaaga 7020
cggatgatag ccatgattgg accaagctgc gttatatgga caatcacatg ccagcagacg 7080
cagagcgggc cgggctattt gtaagaacgt cagcaccgtg cacgattact ggaacaatgg 7140
gacacttcat tctggcccga tgtccgaaag gagaaactct gacggtgggg ttcactgacg 7200
gtaggaagat cagtcactca tgtacgcacc catttcacca tgaccctcct gtgataggcc 7260
gggaaaaatt ccattcccga ccgcagcacg gtagggaact accttgcagc acgtacgcgc 7320
agagcaccgc tgcaactgcc gaggagatag aggtacacat gcccccagac accccagatc 7380
gcacattaat gtcacaacag tccggcaatg taaagatcac agtcaatagt cagacggtgc 7440
ggtacaagtg caattgtggt gactcaagtg aaggattaac cactacagat aaagtgatta 7500
ataactgcaa ggtcgatcaa tgccatgccg cggtcaccaa tcacaaaaaa tggcagtata 7560
attcccctct ggtcccgcgt aatgctgaat tcggggaccg gaaaggaaaa gttcacattc 7620
catttcctct ggcaaatgtg acatgcaggg tgcctaaagc aagaaacccc accgtgacgt 7680
acggaaaaaa ccaagtcatc atgttgctgt atcctgacca cccaacgctc ctgtcctaca 7740
ggaatatggg agaagaacca aactatcaag aagagtgggt gacgcataag aaggagatca 7800
ggttaaccgt gccgactgag gggctcgagg tcacgtgggg taacaatgag ccgtacaagt 7860
attggccgca gttatccaca aacggtacag cccacggcca cccgcatgag ataattctgt 7920
attattatga gctgtaccca actatgactg cggtagtttt gtcagtggcc tcgttcatac 7980
tcctgtcgat ggtgggtgtg gcagtgggga tgtgcatgtg tgcacgacgc agatgcatta 8040
caccgtacga actgacacca ggagctaccg tccctttcct gcttagccta atatgctgca 8100
ttagaacagc taaagcggcc acataccagg aggccgcggt atacctgtgg aacgagcagc 8160
agcctttatt ttggatgcaa gcccttattc cgctggcagc cctgattgtc ctatgtaact 8220
gtctgagact cttaccatgc tgttgtaaaa tgttgacttt tttagccgta ctgagcgtcg 8280
gtgcccacac tgtgagcgcg tacgaacacg taacagtgat cccgaacacg gtgggagtac 8340
cgtataagac tctagtcaac agaccgggct acagccccat ggtattggag atggagcttc 8400
tgtctgtcac cttggaacca acgctatcgc ttgattacat cacgtgcgag tataaaaccg 8460
ttatcccgtc tccgtacgtg aaatgctgcg gtacagcaga gtgtaaggac aagagcctac 8520
ctgattacag ctgtaaggtc ttcaccggcg tctacccatt catgtggggc ggcgcctact 8580
gcttctgcga caccgaaaat acgcaattga gcgaagcaca tgtggagaag tccgaatcat 8640
gcaaaacaga atttgcatca gcatacaggg ctcataccgc atccgcatca gctaagctcc 8700
gcgtccttta ccaaggaaat aatatcactg tggctgctta tgcaaacggc gaccatgccg 8760
tcacagttaa ggacgctaaa ttcatagtgg ggccaatgtc ttcagcctgg acacctttcg 8820
acaataaaat cgtggtgtac aaaggcgacg tctacaacat ggactacccg cccttcggcg 8880
caggaagacc aggacaattt ggcgacatcc aaagtcgcac gcctgagagc gaagacgtct 8940
atgctaatac acaactggta ctgcagagac cgtccgcggg tacggtgcac gtgccgtact 9000
ctcaggcacc atctggcttc aagtattggc taaaagaacg aggggcgtcg ctgcagcaca 9060
cagcaccatt tggctgtcaa atagcaacaa acccggtaag agcgatgaac tgcgccgtag 9120
ggaacatgcc tatctccatc gacataccgg acgcggcctt taccagggtc gtcgacgcgc 9180
catctttaac ggacatgtcg tgtgaggtat cagcctgcac ccattcctca gactttgggg 9240
gcgtagccat cattaaatat gcagccagta agaaaggcaa gtgtgcagtg cactcgatga 9300
ctaacgccgt cactattcgg gaagctgaaa tagaagtaga agggaactct cagttgcaaa 9360
tctctttttc gacggcccta gccagcgccg aatttcgcgt acaagtctgt tctacacaag 9420
tacactgtgc agccgagtgc catccaccga aagaccatat agtcaattac ccggcgtcac 9480
acaccaccct cggggtccaa gacatttccg ctacggcgat gtcatgggtg cagaagatca 9540
cgggaggtgt gggactggtt gtcgctgttg cagcactgat cctaatcgtg gtgctatgcg 9600
tgtcgtttag caggcactaa cttgacaact aggtatgaag gcatacgcgt ccctaaagag 9660
acacaccgca tatagctagg aatcaacaga taagtataga tctaagggct gaacaacccc 9720
tgaataacaa aatataaaaa tcaacaaaaa tcataaaata gaaaactaga aatagaagta 9780
ggtaagaagg tatatgtgtc ccctaagaga cacaccatat atagctaaga atcaatagat 9840
aagcatagat caaagggctg aacaacccct gaataataac aaaatataaa aaccaataaa 9900
aatcataaaa tagaaaatca acaaaaatca taaaatagaa aactagaaat agaagtaggt 9960
aagaaggtat atgtgtcccc taagagacac accatatata gctaagaatc aatagataag 10020
catagatcaa agggctgaac aacccctgaa taataacaaa atataaaaac caataaaaat 10080
cataaaatag aaaaccacaa atagaagtag ttcaaagggc tataaaaccc ctgaatagta 10140
acaaaatata aaactaataa aaatcaaacg aataccataa ttggcaatcg gaagagatgt 10200
aggtacttaa gcttcttaaa agcagccgaa ctcgctttga gatgtaggcg tagcacaccg 10260
aactcttcca taattctccg aacccacagg gacgtaggag atgttcaaag tgactataaa 10320
accctgaaca gtaataaaat ataaaattaa taatgagtac cataattggc aaatggaaga 10380
gacgtaggta ctaagcttct taaaagcagc cgaactcact ttgagatgta ggcatagcat 10440
accgaactct tccacaattc tccgtaccca tagggacgta ggagatgtta ttttgttttt 10500
aatatttcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 10549
<210> 45
<211> 1186
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 45
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccatcaaca aaaatcataa aatagaaaac tagaaataga agtaggtaag 600
aaggtatatg tgtcccctaa gagacacacc atatatagct aagaatcaat agataagcat 660
agatcaaagg gctgaacaac ccctgaataa taacaaaata taaaaaccaa taaaaatcat 720
aaaatagaaa accacaaata gaagtagttc aaagggctat aaaacccctg aatagtaaca 780
aaatataaaa ctaataaaaa tcaaacgaat accataattg gcaatcggaa gagatgtagg 840
tacttaagct tcttaaaagc agccgaactc gctttgagat gtaggcgtag cacaccgaac 900
tcttccataa ttctccgaac ccacagggac gtaggagatg ttcaaagtga ctataaaacc 960
ctgaacagta ataaaatata aaattaataa tgagtaccat aattggcaaa tggaagagac 1020
gtaggtacta agcttcttaa aagcagccga actcactttg agatgtaggc atagcatacc 1080
gaactcttcc acaattctcc gtacccatag ggacgtagga gatgttattt tgtttttaat 1140
atttcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1186
<210> 46
<211> 1106
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 46
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccaatagct aagaatcaat agataagcat agatcaaagg gctgaacaac 600
ccctgaataa taacaaaata taaaaaccaa taaaaatcat aaaatagaaa accacaaata 660
gaagtagttc aaagggctat aaaacccctg aatagtaaca aaatataaaa ctaataaaaa 720
tcaaacgaat accataattg gcaatcggaa gagatgtagg tacttaagct tcttaaaagc 780
agccgaactc gctttgagat gtaggcgtag cacaccgaac tcttccataa ttctccgaac 840
ccacagggac gtaggagatg ttcaaagtga ctataaaacc ctgaacagta ataaaatata 900
aaattaataa tgagtaccat aattggcaaa tggaagagac gtaggtacta agcttcttaa 960
aagcagccga actcactttg agatgtaggc atagcatacc gaactcttcc acaattctcc 1020
gtacccatag ggacgtagga gatgttattt tgtttttaat atttcaaaaa aaaaaaaaaa 1080
aaaaaaaaaa aaaaaaaaaa aaaaaa 1106
<210> 47
<211> 9566
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 47
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatagagca 2700
gtgtccgacc gtacaagaaa cagcggagac gcgtgacaca gctatttcct ttcgggcacc 2760
gccaagtatc accgtggaac tgagccatcc accgatctcc ttcggagcac caagcgagac 2820
gttccccatc acatttgggg acttcaacga tggagaaatc gaaagcttgt cttctgagct 2880
actaactttc ggagacttcc tacccggtga agtggatgat ttgacagata gcgactggtc 2940
cacgtgctca gacacggacg acgagttatg actagacagg gcaggtgggt atatattctc 3000
gtcggacacc ggtccaggcc atttacaaca gaagtcggta cgccagtcag tgctgccggt 3060
aaacaccctg gaggaagttc acgaggagaa gtgttaccca cctaagctgg atgaattaaa 3120
ggagcaacta ctacttaaga aactccagga gagtgcgtcc acggccaata gaagcaggta 3180
tcaatcacgc aaagtggaaa atatgaaagc aacaatcatc cagagactaa agagaggctg 3240
taaactgtat ttaatggcag agaccccgaa agtcccgact tatcggaccg tatacccggc 3300
gcctgtgtac tcgcctccga tcaacgtccg attgtccaat cccgagtccg cagtggcagc 3360
atgtaatgag ttcttagcta gaaactaccc aactgtttca tcataccaaa tcaccgatga 3420
gtatgatgca tatctagaca tggtggacgg gtcggagagt tgcttggacc gagcgacatt 3480
caatccgtca aaacttagga gctacccgaa acaacatgct tatcacgcgc cctctatcag 3540
aagcgctgta ccttccccat tccagaacac actacagaat gtactggcag cagccacgaa 3600
aaggaactgc aacgtcacac agatgaggga attacccact ttggactcag cagtattcaa 3660
cgtggagtgt tttaaaaaat tcgcatgcaa ccgagaatac tgggaagaat ttgctgccag 3720
ccctatcagg ataacgactg agaatctaac aacctatgtc actaaattaa aggggccaaa 3780
agcagcagcg ttgcttgcaa gaacccataa tctgctgccg ctgcaggatg taccaatgga 3840
taggttcaca gtagatatga aaagggacgt gaaggtaact cctggcacaa agcatacaga 3900
ggaaaggcct aaggtgcagg ttatacaggc ggctgaaccc ttggcaacag cgtacctatg 3960
tggaattcac agagaattgg ttaggagatt gaacgccgtc ctcctaccca acgtgcatac 4020
actatttgac atgtctgccg aggacttcga tgccattata gccgcacact ttaagccagg 4080
agacgccgtt ttagaaacgg acatagcctc ctttgataag agccaggatg attcacttgc 4140
gcttaccgcc ttaatgctgt tagaagattt gggagtggat cactccttgt tggacctgat 4200
agaggctgct tttggagaga tttccagctg tcacctgccg acaggtacgc gcttcaagtt 4260
cggcgctatg atgaaatccg gtatgttcct aactctgttc gtcaacacat tgttaaatat 4320
caccatcgct agccgggtgt tggaagatcg tctgacaaaa tctgcatgcg cggccttcat 4380
cggcgacgac aacataatac atggtgtcgt ctccgatgaa ttgatggcag ccagatgcgc 4440
tacttggatg aacatggaag tgaagatcat agatgcagtt gtatcccaga aagctcccta 4500
cttttgtgga gggtttatac tgcatgatac tgtgacagga acagcttgca gggtggcgga 4560
cccgctaaaa aggttattta aactgggcaa accgttagcg gcaggtgacg aacaagacga 4620
agacagaagg cgggcgctgg ctgatgaagt aatcagatgg caacgaacag ggctaataga 4680
tgagctggag aaagcggtgt actctaggta cgaagtgcag ggtatatcag ttgctgtaat 4740
gtccatggcc acctttgcaa gctccagatc caacttcgag aagctcagag gacccgtcat 4800
aaccttgtac ggcggtccta aataggtacg cactacagct acctattttg caaaagccga 4860
cagcaggtac ctaaatacca atcagccata atggagttta tcccaaccca aactttctac 4920
aataggaggt accagcctcg accttggact ccgcgcccta ctatccaagt catcagaccc 4980
agaccgcgtc cgcaaaggaa ggccgggcaa cttgcccagc tgatctcagc agttaataaa 5040
ctgacaatgc gcgtggtacc tcaacagaag ccgcgcaaga atcggaagaa taagaagcaa 5100
aagcaaaagc agcaggcgcc acgaaacaat acgaatcaaa agaagcagcc ccccaaaaag 5160
aaaccggttc aaaagaaaaa gaagccgggc cgcagagaga gaatgtgcat gaaaatcgaa 5220
aatgattgca tcttcgaagt caagcatgaa ggtaaggtaa caggttacgc gtgcttggta 5280
ggggacaaag taatgaagcc agcacacgta aaggggacca tcgataacgc ggacctggcc 5340
aaattggcct tcaagcggtc atctaagtac gaccttgaat gcgcgcagat acccgtgcac 5400
atgaagtccg acgcttcgaa gttcacccat gagaaaccgg aggggtacta caactggcac 5460
cacggagcag tacagtactc aggaggccga ttcaccatcc ctacaggtgc gggcaaacca 5520
ggggatagtg gtagaccgat cttcgacaac aaggggcgcg tggtggccat agttttagga 5580
ggagctaatg aaggagcccg tacagccctc tcggtggtga cctggaacaa agacatcgtc 5640
acgaaaatca cccctgaggg ggccgaagag tggagtctgg ccattccagt tatgtgcctg 5700
ctggcaaata ccacgttccc ctgctcccgg cccccttgca caccctgctg ctacgaaaaa 5760
gagccggaga aaaccttgcg catgcttgaa gacaatgtca tgagccccgg gtactatcag 5820
ctgctacaag catccttaac atgttctccc cgacgccagc ggcgcagtat taaggaccac 5880
ttcaatgtct ataaagccac aagaccgtac ctagctcact gtcccgactg tggagaaggg 5940
cactcgtgcc atagtcccgt agcgctagaa cgcatcagaa acgaagcgac agacgggacg 6000
ttgaaaatcc aggtttcctt gcaaatcgga ataaagacgg atgatagcca tgattggacc 6060
aagctgcgtt atatggacaa tcacatgcca gcagacgcag agcgggccgg gctatttgta 6120
agaacgtcag caccgtgcac gattactgga acaatgggac acttcattct ggcccgatgt 6180
ccgaaaggag aaactctgac ggtggggttc actgacggta ggaagatcag tcactcatgt 6240
acgcacccat ttcaccatga ccctcctgtg ataggccggg aaaaattcca ttcccgaccg 6300
cagcacggta gggaactacc ttgcagcacg tacgcgcaga gcaccgctgc aactgccgag 6360
gagatagagg tacacatgcc cccagacacc ccagatcgca cattaatgtc acaacagtcc 6420
ggcaatgtaa agatcacagt caatagtcag acggtgcggt acaagtgcaa ttgtggtgac 6480
tcaagtgaag gattaaccac tacagataaa gtgattaata actgcaaggt cgatcaatgc 6540
catgccgcgg tcaccaatca caaaaaatgg cagtataatt cccctctggt cccgcgtaat 6600
gctgaattcg gggaccggaa aggaaaagtt cacattccat ttcctctggc aaatgtgaca 6660
tgcagggtgc ctaaagcaag aaaccccacc gtgacgtacg gaaaaaacca agtcatcatg 6720
ttgctgtatc ctgaccaccc aacgctcctg tcctacagga atatgggaga agaaccaaac 6780
tatcaagaag agtgggtgac gcataagaag gagatcaggt taaccgtgcc gactgagggg 6840
ctcgaggtca cgtggggtaa caatgagccg tacaagtatt ggccgcagtt atccacaaac 6900
ggtacagccc acggccaccc gcatgagata attctgtatt attatgagct gtacccaact 6960
atgactgcgg tagttttgtc agtggcctcg ttcatactcc tgtcgatggt gggtgtggca 7020
gtggggatgt gcatgtgtgc acgacgcaga tgcattacac cgtacgaact gacaccagga 7080
gctaccgtcc ctttcctgct tagcctaata tgctgcatta gaacagctaa agcggccaca 7140
taccaggagg ccgcggtata cctgtggaac gagcagcagc ctttattttg gatgcaagcc 7200
cttattccgc tggcagccct gattgtccta tgtaactgtc tgagactctt accatgctgt 7260
tgtaaaatgt tgactttttt agccgtactg agcgtcggtg cccacactgt gagcgcgtac 7320
gaacacgtaa cagtgatccc gaacacggtg ggagtaccgt ataagactct agtcaacaga 7380
ccgggctaca gccccatggt attggagatg gagcttctgt ctgtcacctt ggaaccaacg 7440
ctatcgcttg attacatcac gtgcgagtat aaaaccgtta tcccgtctcc gtacgtgaaa 7500
tgctgcggta cagcagagtg taaggacaag agcctacctg attacagctg taaggtcttc 7560
accggcgtct acccattcat gtggggcggc gcctactgct tctgcgacac cgaaaatacg 7620
caattgagcg aagcacatgt ggagaagtcc gaatcatgca aaacagaatt tgcatcagca 7680
tacagggctc ataccgcatc cgcatcagct aagctccgcg tcctttacca aggaaataat 7740
atcactgtgg ctgcttatgc aaacggcgac catgccgtca cagttaagga cgctaaattc 7800
atagtggggc caatgtcttc agcctggaca cctttcgaca ataaaatcgt ggtgtacaaa 7860
ggcgacgtct acaacatgga ctacccgccc ttcggcgcag gaagaccagg acaatttggc 7920
gacatccaaa gtcgcacgcc tgagagcgaa gacgtctatg ctaatacaca actggtactg 7980
cagagaccgt ccgcgggtac ggtgcacgtg ccgtactctc aggcaccatc tggcttcaag 8040
tattggctaa aagaacgagg ggcgtcgctg cagcacacag caccatttgg ctgtcaaata 8100
gcaacaaacc cggtaagagc gatgaactgc gccgtaggga acatgcctat ctccatcgac 8160
ataccggacg cggcctttac cagggtcgtc gacgcgccat ctttaacgga catgtcgtgt 8220
gaggtatcag cctgcaccca ttcctcagac tttgggggcg tagccatcat taaatatgca 8280
gccagtaaga aaggcaagtg tgcagtgcac tcgatgacta acgccgtcac tattcgggaa 8340
gctgaaatag aagtagaagg gaactctcag ttgcaaatct ctttttcgac ggccctagcc 8400
agcgccgaat ttcgcgtaca agtctgttct acacaagtac actgtgcagc cgagtgccat 8460
ccaccgaaag accatatagt caattacccg gcgtcacaca ccaccctcgg ggtccaagac 8520
atttccgcta cggcgatgtc atgggtgcag aagatcacgg gaggtgtggg actggttgtc 8580
gctgttgcag cactgatcct aatcgtggtg ctatgcgtgt cgtttagcag gcactaactt 8640
gacaactagg tatgaaggca tacgcgtccc taaagagaca caccgcatat agctaggaat 8700
caacagataa gtatagatct aagggctgaa caacccctga ataacaaaat ataaaaatca 8760
acaaaaatca taaaatagaa aactagaaat agaagtaggt aagaaggtat atgtgtcccc 8820
taagagacac accatatata gctaagaatc aatagataag catagatcaa agggctgaac 8880
aacccctgaa taataacaaa atataaaaac caataaaaat cataaaatag aaaatcaaca 8940
aaaatcataa aatagaaaac tagaaataga agtaggtaag aaggtatatg tgtcccctaa 9000
gagacacacc atatatagct aagaatcaat agataagcat agatcaaagg gctgaacaac 9060
ccctgaataa taacaaaata taaaaaccaa taaaaatcat aaaatagaaa accacaaata 9120
gaagtagttc aaagggctat aaaacccctg aatagtaaca aaatataaaa ctaataaaaa 9180
tcaaacgaat accataattg gcaatcggaa gagatgtagg tacttaagct tcttaaaagc 9240
agccgaactc gctttgagat gtaggcgtag cacaccgaac tcttccataa ttctccgaac 9300
ccacagggac gtaggagatg ttcaaagtga ctataaaacc ctgaacagta ataaaatata 9360
aaattaataa tgagtaccat aattggcaaa tggaagagac gtaggtacta agcttcttaa 9420
aagcagccga actcactttg agatgtaggc atagcatacc gaactcttcc acaattctcc 9480
gtacccatag ggacgtagga gatgttattt tgtttttaat atttcaaaaa aaaaaaaaaa 9540
aaaaaaaaaa aaaaaaaaaa aaaaaa 9566
<210> 48
<211> 6389
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 48
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taatctgcgt 3900
actgggacgt aagtttagat cgtccagagc attgaaacca ccatgtatca ccagtaatac 3960
tgagatgttc ttcctattta gcagttttga caatggcaga aggaatttta caacgcatgt 4020
tatgaacaat caactgaacg cagcctttgt aggacaggcc acccgagcag gatgtgcacc 4080
atcgtaccgg gtaaagcgca tggacatcgc gaagaacgat gaagagtgcg tggtcaacgc 4140
cgccaaccct cgcgggttac cgggtgacgg tgtttgcaag gcagtatata aaaaatggcc 4200
ggagtccttt aaaaatagtg caacaccagt aggaaccgca aaaacagtta tgtgcggtac 4260
atatccagta atccatgccg taggaccaaa cttctcaaat tacacggagt ccgaagggga 4320
ccgggaattg gcggctgcct atcgagaagt cgcaaaggaa gtaactagac tgggagtaaa 4380
tagcgtagct atacctctcc tctccacagg tgtatactca ggagggaaag acaggctaac 4440
ccagtcactg aaccacctct ttacagccat ggactcgacg gatgcagacg tggtcatcta 4500
ctgccgagac aaggaatggg agaagaaaat atctgaggcc atacagatgc ggacccaagt 4560
ggagctgctg gatgagcaca tctccataga ctgcgatgtc attcgcgtgc accctgacag 4620
tagtttggca ggtagaaaag gatacagcac cacggaaggc gcactgtatt catatctaga 4680
agggacacgt tttcaccaga cggcagtgga tgtggcagag atacatacta tgtggccaaa 4740
gcaaatagag gccaatgagc aagtctgcct atatgccctg ggggaaagta ttgagtcaat 4800
caggcagaaa tgcccggtgg atgatgcaga tgcatcatct cccccgaaaa ccgtcccgtg 4860
cctttgccgt tatgccatga ctcctgaacg cgtcacccga cttcgcatga accatgtcac 4920
aaatataatt gtgtgttctt catttcccct tccaaagtac aagatagaag gagtgcaaaa 4980
agtcaaatgc tccaaggtaa tgttatttga tcacaatgtg ccatcgcgcg taagtccaag 5040
ggaatacaga tcttcccagg agtctgtacg ggaagtgagt atgacaacgt cattgacgca 5100
tagtcagttt gatctaagcg ccgatggcga gacactgccc gtcccgtcag acctggatgc 5160
tgacgcccca gccctagaac cggccctaga cgacggggcg atacatacga ccggaaacct 5220
tgcggccgtg tctgactggg taatgagcac cgtacccgtc gcgccgccta gaagaaggag 5280
agggagaaac ctgaccgtga tatgtgacga gagagaaggg aatataacac ccatggctag 5340
cgtccgattc tttagagcag agcagtgtcc gaccgtacaa gaaacagcgg agacgcgtga 5400
cacagctatt tcctttcggg caccgccaag tatcaccgtg gaactgagcc atccaccgat 5460
ctccttcgga gcaccaagcg agacgttccc catcacattt ggggacttca acgatggaga 5520
aatcgaaagc ttgtcttctg agctactaac tttcggagac ttcctacccg gtgaagtgga 5580
tgatttgaca gatagcgact ggtccacgtg ctcagacacg gacgacgagg tatatgtgtc 5640
ccctaagaga cacaccatat atagctaaga atcaatagat aagcatagat caaagggctg 5700
aacaacccct gaataataac aaaatataaa aaccaataaa aatcataaaa tagaaaatca 5760
acaaaaatca taaaatagaa aactagaaat agaagtaggt aagaaggtat atgtgtcccc 5820
taagagacac accatatata gctaagaatc aatagataag catagatcaa agggctgaac 5880
aacccctgaa taataacaaa atataaaaac caataaaaat cataaaatag aaaaccacaa 5940
atagaagtag ttcaaagggc tataaaaccc ctgaatagta acaaaatata aaactaataa 6000
aaatcaaacg aataccataa ttggcaatcg gaagagatgt aggtacttaa gcttcttaaa 6060
agcagccgaa ctcgctttga gatgtaggcg tagcacaccg aactcttcca taattctccg 6120
aacccacagg gacgtaggag atgttcaaag tgactataaa accctgaaca gtaataaaat 6180
ataaaattaa taatgagtac cataattggc aaatggaaga gacgtaggta ctaagcttct 6240
taaaagcagc cgaactcact ttgagatgta ggcatagcat accgaactct tccacaattc 6300
tccgtaccca tagggacgta ggagatgtta ttttgttttt aatatttcaa aaaaaaaaaa 6360
aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 6389
<210> 49
<211> 6598
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 49
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taatctgcgt 3900
actgggacgt aagtttagat cgtccagagc attgaaacca ccatgtatca ccagtaatac 3960
tgagatgttc ttcctattta gcagttttga caatggcaga aggaatttta caacgcatgt 4020
tatgaacaat caactgaacg cagcctttgt aggacaggcc acccgagcag gatgtgcacc 4080
atcgtaccgg gtaaagcgca tggacatcgc gaagaacgat gaagagtgcg tggtcaacgc 4140
cgccaaccct cgcgggttac cgggtgacgg tgtttgcaag gcagtatata aaaaatggcc 4200
ggagtccttt aaaaatagtg caacaccagt aggaaccgca aaaacagtta tgtgcggtac 4260
atatccagta atccatgccg taggaccaaa cttctcaaat tacacggagt ccgaagggga 4320
ccgggaattg gcggctgcct atcgagaagt cgcaaaggaa gtaactagac tgggagtaaa 4380
tagcgtagct atacctctcc tctccacagg tgtatactca ggagggaaag acaggctaac 4440
ccagtcactg aaccacctct ttacagccat ggactcgacg gatgcagacg tggtcatcta 4500
ctgccgagac aaggaatggg agaagaaaat atctgaggcc atacagatgc ggacccaagt 4560
ggagctgctg gatgagcaca tctccataga ctgcgatgtc attcgcgtgc accctgacag 4620
tagtttggca ggtagaaaag gatacagcac cacggaaggc gcactgtatt catatctaga 4680
agggacacgt tttcaccaga cggcagtgga tgtggcagag atacatacta tgtggccaaa 4740
gcaaatagag gccaatgagc aagtctgcct atatgccctg ggggaaagta ttgagtcaat 4800
caggcagaaa tgcccggtgg atgatgcaga tgcatcatct cccccgaaaa ccgtcccgtg 4860
cctttgccgt tatgccatga ctcctgaacg cgtcacccga cttcgcatga accatgtcac 4920
aaatataatt gtgtgttctt catttcccct tccaaagtac aagatagaag gagtgcaaaa 4980
agtcaaatgc tccaaggtaa tgttatttga tcacaatgtg ccatcgcgcg taagtccaag 5040
ggaatacaga tcttcccagg agtctgtacg ggaagtgagt atgacaacgt cattgacgca 5100
tagtcagttt gatctaagcg ccgatggcga gacactgccc gtcccgtcag acctggatgc 5160
tgacgcccca gccctagaac cggccctaga cgacggggcg atacatacga ccggaaacct 5220
tgcggccgtg tctgactggg taatgagcac cgtacccgtc gcgccgccta gaagaaggag 5280
agggagaaac ctgaccgtga tatgtgacga gagagaaggg aatataacac ccatggctag 5340
cgtccgattc tttagagcag agcagtgtcc gaccgtacaa gaaacagcgg agacgcgtga 5400
cacagctatt tcctttcggg caccgccaag tatcaccgtg gaactgagcc atccaccgat 5460
ctccttcgga gcaccaagcg agacgttccc catcacattt ggggacttca acgatggaga 5520
aatcgaaagc ttgtcttctg agctactaac tttcggagac ttcctacccg gtgaagtgga 5580
tgatttgaca gatagcgact ggtccacgtg ctcagacacg gacgacgagt tatgactaga 5640
cagggcaggt gggtatatat tctcgtcgga caccggtcca ggccatttac aacagaagtc 5700
ggtacgccag tcagtgctgc cggtaaacac cctggaggaa gttcacgagg agaagtgtta 5760
cccacctaag ctggatgaat taaaggagca actactactt aagaaactcc aggagagtgc 5820
gtccacggcc aatagaagca ggtatcaatc acgcaaagtg gaaaatatga aagcaacaat 5880
catccagaga ctaaaggatc aaagggctga acaacccctg aataataaca aaatataaaa 5940
accaataaaa atcataaaat agaaaatcaa caaaaatcat aaaatagaaa actagaaata 6000
gaagtaggta agaaggtata tgtgtcccct aagagacaca ccatatatag ctaagaatca 6060
atagataagc atagatcaaa gggctgaaca acccctgaat aataacaaaa tataaaaacc 6120
aataaaaatc ataaaataga aaaccacaaa tagaagtagt tcaaagggct ataaaacccc 6180
tgaatagtaa caaaatataa aactaataaa aatcaaacga ataccataat tggcaatcgg 6240
aagagatgta ggtacttaag cttcttaaaa gcagccgaac tcgctttgag atgtaggcgt 6300
agcacaccga actcttccat aattctccga acccacaggg acgtaggaga tgttcaaagt 6360
gactataaaa ccctgaacag taataaaata taaaattaat aatgagtacc ataattggca 6420
aatggaagag acgtaggtac taagcttctt aaaagcagcc gaactcactt tgagatgtag 6480
gcatagcata ccgaactctt ccacaattct ccgtacccat agggacgtag gagatgttat 6540
tttgttttta atatttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 6598
<210> 50
<211> 6628
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 50
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga taatggcggg 3060
catctgcagt caccaagtga cctttgacac gttccaaaac aaagccaacg tttgctgggc 3120
taagagcttg gtccctatcc tcgaaacagc ggggataaaa ctaaatgata ggcagtggtc 3180
ccagataatt caagctttca aagaagacaa agcatactca cccgaagtag ccctgaatga 3240
aatatgcacg cgcatgtatg gggtggatct agacagcggg ctattctcta aaccgttggt 3300
atctgtgtat tacgcggata accactggga taataggccg ggaggaaaga tgttcggatt 3360
caaccctgag gcagcgtcca ttctagaaag aaagtacccg tttacaaaag gaaagtggaa 3420
catcaacaag cagatctgcg tgactaccag gaggatagaa gacttcaacc ctaccaccaa 3480
cattataccg gccaacagga gactaccaca ctcattagtg gccgaacacc gcccagtaaa 3540
aggggaaaga atggaatggc tggttaacaa gataaacgga catcatgtgc tcctggttag 3600
cggctataac cttgcactgc ctactaagag agtcacctgg gtagcgccac taggtgtccg 3660
cggagcggac tatacataca acctagagct gggtctaccg gcaacacttg gtaggtatga 3720
cctagtggtc ataaacatcc acacaccttt tcgcatacac cattaccaac agtgcgtaga 3780
tcacgcaatg aaactgcaaa tgctaggagg tgactcactg agactgctca aaccgggtgg 3840
ctctctattg atcagagcat acggttacgc agatagaacc agtgaacgag taatctgcgt 3900
actgggacgt aagtttagat cgtccagagc attgaaacca ccatgtatca ccagtaatac 3960
tgagatgttc ttcctattta gcagttttga caatggcaga aggaatttta caacgcatgt 4020
tatgaacaat caactgaacg cagcctttgt aggacaggcc acccgagcag gatgtgcacc 4080
atcgtaccgg gtaaagcgca tggacatcgc gaagaacgat gaagagtgcg tggtcaacgc 4140
cgccaaccct cgcgggttac cgggtgacgg tgtttgcaag gcagtatata aaaaatggcc 4200
ggagtccttt aaaaatagtg caacaccagt aggaaccgca aaaacagtta tgtgcggtac 4260
atatccagta atccatgccg taggaccaaa cttctcaaat tacacggagt ccgaagggga 4320
ccgggaattg gcggctgcct atcgagaagt cgcaaaggaa gtaactagac tgggagtaaa 4380
tagcgtagct atacctctcc tctccacagg tgtatactca ggagggaaag acaggctaac 4440
ccagtcactg aaccacctct ttacagccat ggactcgacg gatgcagacg tggtcatcta 4500
ctgccgagac aaggaatggg agaagaaaat atctgaggcc atacagatgc ggacccaagt 4560
ggagctgctg gatgagcaca tctccataga ctgcgatgtc attcgcgtgc accctgacag 4620
tagtttggca ggtagaaaag gatacagcac cacggaaggc gcactgtatt catatctaga 4680
agggacacgt tttcaccaga cggcagtgga tgtggcagag atacatacta tgtggccaaa 4740
gcaaatagag gccaatgagc aagtctgcct atatgccctg ggggaaagta ttgagtcaat 4800
caggcagaaa tgcccggtgg atgatgcaga tgcatcatct cccccgaaaa ccgtcccgtg 4860
cctttgccgt tatgccatga ctcctgaacg cgtcacccga cttcgcatga accatgtcac 4920
aaatataatt gtgtgttctt catttcccct tccaaagtac aagatagaag gagtgcaaaa 4980
agtcaaatgc tccaaggtaa tgttatttga tcacaatgtg ccatcgcgcg taagtccaag 5040
ggaatacaga tcttcccagg agtctgtacg ggaagtgagt atgacaacgt cattgacgca 5100
tagtcagttt gatctaagcg ccgatggcga gacactgccc gtcccgtcag acctggatgc 5160
tgacgcccca gccctagaac cggccctaga cgacggggcg atacatacga ccggaaacct 5220
tgcggccgtg tctgactggg taatgagcac cgtacccgtc gcgccgccta gaagaaggag 5280
agggagaaac ctgaccgtga tatgtgacga gagagaaggg aatataacac ccatggctag 5340
cgtccgattc tttagagcag agcagtgtcc gaccgtacaa gaaacagcgg agacgcgtga 5400
cacagctatt tcctttcggg caccgccaag tatcaccgtg gaactgagcc atccaccgat 5460
ctccttcgga gcaccaagcg agacgttccc catcacattt ggggacttca acgatggaga 5520
aatcgaaagc ttgtcttctg agctactaac tttcggagac ttcctacccg gtgaagtgga 5580
tgatttgaca gatagcgact ggtccacgtg ctcagacacg gacgacgagt tatgactaga 5640
cagggcaggt gggtatatat tctcgtcgga caccggtcca ggccatttac aacagaagtc 5700
ggtacgccag tcagtgctgc cggtaaacac cctggaggaa gttcacgagg agaagtgtta 5760
cccacctaag ctggatgaat taaaggagca actactactt aagaaactcc aggagagtgc 5820
gtccacggcc aatagaagca ggtatcaatc acgcaaagtg gaaaatatga aagcaacaat 5880
catccagaga ctaaagagag gctgtaaact gtatttaatg gcagagaccc cgaaagtccc 5940
gacttatcgg accgtatacc cggcgcctgt gtactcgcct ccgatcaacg tccgattgtc 6000
caatcccgag tccgcagtgg cagcatgtaa tgagttctta gctagaaact acccaactgt 6060
ttcatcatac caaatcaccg atgagtatga tgcatatcta gacatggtgg acgggtcgga 6120
gagttgcttg gaccgagcga cattcaatcc gtcaaaactt aggagctacc cgaaacaaca 6180
tggaagtagt tcaaagggct ataaaacccc tgaatagtaa caaaatataa aactaataaa 6240
aatcaaacga ataccataat tggcaatcgg aagagatgta ggtacttaag cttcttaaaa 6300
gcagccgaac tcgctttgag atgtaggcgt agcacaccga actcttccat aattctccga 6360
acccacaggg acgtaggaga tgttcaaagt gactataaaa ccctgaacag taataaaata 6420
taaaattaat aatgagtacc ataattggca aatggaagag acgtaggtac taagcttctt 6480
aaaagcagcc gaactcactt tgagatgtag gcatagcata ccgaactctt ccacaattct 6540
ccgtacccat agggacgtag gagatgttat tttgttttta atatttcaaa aaaaaaaaaa 6600
aaaaaaaaaa aaaaaaaaaa aaaaaaaa 6628
<210> 51
<211> 9138
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 51
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgat 2700
tgtagtggac actacgggct caacaaaacc tgaccctgga gacctcgtgt taacgtgctt 2760
cagagggtgg gttaaacaac tgcaaattga ctatcgtgga cacgaggtca tgacagcagc 2820
cgcatcccaa gggttaacca gaaaaggagt ttacgcagtt aggcaaaaag ttaacgaaaa 2880
cccactctat gcatcaacat cagagcacgt caacgtactc ctaacgcgta cggaaggtaa 2940
actggtatgg aagacactct ctggtgaccc gtggataaag acgctgcaga acccaccgaa 3000
aggaaacttc aaggcaacta ttaaggagtg ggaggtggag cacgcatcga ttcaatccgt 3060
caaaacttag gagctacccg aaacaacatg cttatcacgc gccctctatc agaagcgctg 3120
taccttcccc attccagaac acactacaga atgtactggc agcagccacg aaaaggaact 3180
gcaacgtcac acagatgagg gaattaccca ctttggactc agcagtattc aacgtggagt 3240
gttttaaaaa attcgcatgc aaccgagaat actgggaaga atttgctgcc agccctatca 3300
ggataacgac tgagaatcta acaacctatg tcactaaatt aaaggggcca aaagcagcag 3360
cgttgcttgc aagaacccat aatctgctgc cgctgcagga tgtaccaatg gataggttca 3420
cagtagatat gaaaagggac gtgaaggtaa ctcctggcac aaagcataca gaggaaaggc 3480
ctaaggtgca ggttatacag gcggctgaac ccttggcaac agcgtaccta tgtggaattc 3540
acagagaatt ggttaggaga ttgaacgccg tcctcctacc caacgtgcat acactatttg 3600
acatgtctgc cgaggacttc gatgccatta tagccgcaca ctttaagcca ggagacgccg 3660
ttttagaaac ggacatagcc tcctttgata agagccagga tgattcactt gcgcttaccg 3720
ccttaatgct gttagaagat ttgggagtgg atcactcctt gttggacctg atagaggctg 3780
cttttggaga gatttccagc tgtcacctgc cgacaggtac gcgcttcaag ttcggcgcta 3840
tgatgaaatc cggtatgttc ctaactctgt tcgtcaacac attgttaaat atcaccatcg 3900
ctagccgggt gttggaagat cgtctgacaa aatctgcatg cgcggccttc atcggcgacg 3960
acaacataat acatggtgtc gtctccgatg aattgatggc agccagatgc gctacttgga 4020
tgaacatgga agtgaagatc atagatgcag ttgtatccca gaaagctccc tacttttgtg 4080
gagggtttat actgcatgat actgtgacag gaacagcttg cagggtggcg gacccgctaa 4140
aaaggttatt taaactgggc aaaccgttag cggcaggtga cgaacaagac gaagacagaa 4200
ggcgggcgct ggctgatgaa gtaatcagat ggcaacgaac agggctaata gatgagctgg 4260
agaaagcggt gtactctagg tacgaagtgc agggtatatc agttgctgta atgtccatgg 4320
ccacctttgc aagctccaga tccaacttcg agaagctcag aggacccgtc ataaccttgt 4380
acggcggtcc taaataggta cgcactacag ctacctattt tgcaaaagcc gacagcaggt 4440
acctaaatac caatcagcca taatggagtt tatcccaacc caaactttct acaataggag 4500
gtaccagcct cgaccttgga ctccgcgccc tactatccaa gtcatcagac ccagaccgcg 4560
tccgcaaagg aaggccgggc aacttgccca gctgatctca gcagttaata aactgacaat 4620
gcgcgtggta cctcaacaga agccgcgcaa gaatcggaag aataagaagc aaaagcaaaa 4680
gcagcaggcg ccacgaaaca atacgaatca aaagaagcag ccccccaaaa agaaaccggt 4740
tcaaaagaaa aagaagccgg gccgcagaga gagaatgtgc atgaaaatcg aaaatgattg 4800
catcttcgaa gtcaagcatg aaggtaaggt aacaggttac gcgtgcttgg taggggacaa 4860
agtaatgaag ccagcacacg taaaggggac catcgataac gcggacctgg ccaaattggc 4920
cttcaagcgg tcatctaagt acgaccttga atgcgcgcag atacccgtgc acatgaagtc 4980
cgacgcttcg aagttcaccc atgagaaacc ggaggggtac tacaactggc accacggagc 5040
agtacagtac tcaggaggcc gattcaccat ccctacaggt gcgggcaaac caggggatag 5100
tggtagaccg atcttcgaca acaaggggcg cgtggtggcc atagttttag gaggagctaa 5160
tgaaggagcc cgtacagccc tctcggtggt gacctggaac aaagacatcg tcacgaaaat 5220
cacccctgag ggggccgaag agtggagtct ggccattcca gttatgtgcc tgctggcaaa 5280
taccacgttc ccctgctccc ggcccccttg cacaccctgc tgctacgaaa aagagccgga 5340
gaaaaccttg cgcatgcttg aagacaatgt catgagcccc gggtactatc agctgctaca 5400
agcatcctta acatgttctc cccgacgcca gcggcgcagt attaaggacc acttcaatgt 5460
ctataaagcc acaagaccgt acctagctca ctgtcccgac tgtggagaag ggcactcgtg 5520
ccatagtccc gtagcgctag aacgcatcag aaacgaagcg acagacggga cgttgaaaat 5580
ccaggtttcc ttgcaaatcg gaataaagac ggatgatagc catgattgga ccaagctgcg 5640
ttatatggac aatcacatgc cagcagacgc agagcgggcc gggctatttg taagaacgtc 5700
agcaccgtgc acgattactg gaacaatggg acacttcatt ctggcccgat gtccgaaagg 5760
agaaactctg acggtggggt tcactgacgg taggaagatc agtcactcat gtacgcaccc 5820
atttcaccat gaccctcctg tgataggccg ggaaaaattc cattcccgac cgcagcacgg 5880
tagggaacta ccttgcagca cgtacgcgca gagcaccgct gcaactgccg aggagataga 5940
ggtacacatg cccccagaca ccccagatcg cacattaatg tcacaacagt ccggcaatgt 6000
aaagatcaca gtcaatagtc agacggtgcg gtacaagtgc aattgtggtg actcaagtga 6060
aggattaacc actacagata aagtgattaa taactgcaag gtcgatcaat gccatgccgc 6120
ggtcaccaat cacaaaaaat ggcagtataa ttcccctctg gtcccgcgta atgctgaatt 6180
cggggaccgg aaaggaaaag ttcacattcc atttcctctg gcaaatgtga catgcagggt 6240
gcctaaagca agaaacccca ccgtgacgta cggaaaaaac caagtcatca tgttgctgta 6300
tcctgaccac ccaacgctcc tgtcctacag gaatatggga gaagaaccaa actatcaaga 6360
agagtgggtg acgcataaga aggagatcag gttaaccgtg ccgactgagg ggctcgaggt 6420
cacgtggggt aacaatgagc cgtacaagta ttggccgcag ttatccacaa acggtacagc 6480
ccacggccac ccgcatgaga taattctgta ttattatgag ctgtacccaa ctatgactgc 6540
ggtagttttg tcagtggcct cgttcatact cctgtcgatg gtgggtgtgg cagtggggat 6600
gtgcatgtgt gcacgacgca gatgcattac accgtacgaa ctgacaccag gagctaccgt 6660
ccctttcctg cttagcctaa tatgctgcat tagaacagct aaagcggcca cataccagga 6720
ggccgcggta tacctgtgga acgagcagca gcctttattt tggatgcaag cccttattcc 6780
gctggcagcc ctgattgtcc tatgtaactg tctgagactc ttaccatgct gttgtaaaat 6840
gttgactttt ttagccgtac tgagcgtcgg tgcccacact gtgagcgcgt acgaacacgt 6900
aacagtgatc ccgaacacgg tgggagtacc gtataagact ctagtcaaca gaccgggcta 6960
cagccccatg gtattggaga tggagcttct gtctgtcacc ttggaaccaa cgctatcgct 7020
tgattacatc acgtgcgagt ataaaaccgt tatcccgtct ccgtacgtga aatgctgcgg 7080
tacagcagag tgtaaggaca agagcctacc tgattacagc tgtaaggtct tcaccggcgt 7140
ctacccattc atgtggggcg gcgcctactg cttctgcgac accgaaaata cgcaattgag 7200
cgaagcacat gtggagaagt ccgaatcatg caaaacagaa tttgcatcag catacagggc 7260
tcataccgca tccgcatcag ctaagctccg cgtcctttac caaggaaata atatcactgt 7320
ggctgcttat gcaaacggcg accatgccgt cacagttaag gacgctaaat tcatagtggg 7380
gccaatgtct tcagcctgga cacctttcga caataaaatc gtggtgtaca aaggcgacgt 7440
ctacaacatg gactacccgc ccttcggcgc aggaagacca ggacaatttg gcgacatcca 7500
aagtcgcacg cctgagagcg aagacgtcta tgctaataca caactggtac tgcagagacc 7560
gtccgcgggt acggtgcacg tgccgtactc tcaggcacca tctggcttca agtattggct 7620
aaaagaacga ggggcgtcgc tgcagcacac agcaccattt ggctgtcaaa tagcaacaaa 7680
cccggtaaga gcgatgaact gcgccgtagg gaacatgcct atctccatcg acataccgga 7740
cgcggccttt accagggtcg tcgacgcgcc atctttaacg gacatgtcgt gtgaggtatc 7800
agcctgcacc cattcctcag actttggggg cgtagccatc attaaatatg cagccagtaa 7860
gaaaggcaag tgtgcagtgc actcgatgac taacgccgtc actattcggg aagctgaaat 7920
agaagtagaa gggaactctc agttgcaaat ctctttttcg acggccctag ccagcgccga 7980
atttcgcgta caagtctgtt ctacacaagt acactgtgca gccgagtgcc atccaccgaa 8040
agaccatata gtcaattacc cggcgtcaca caccaccctc ggggtccaag acatttccgc 8100
tacggcgatg tcatgggtgc agaagatcac gggaggtgtg ggactggttg tcgctgttgc 8160
agcactgatc ctaatcgtgg tgctatgcgt gtcgtttagc aggcactaac ttgacaacta 8220
ggtatgaagg catacgcgtc cctaaagaga cacaccgcat atagctagga atcaacagat 8280
aagtatagat ctaagggctg aacaacccct gaataacaaa atataaaaat caacaaaaat 8340
cataaaatag aaaactagaa atagaagtag gtaagaaggt atatgtgtcc cctaagagac 8400
acaccatata tagctaagaa tcaatagata agcatagatc aaagggctga acaacccctg 8460
aataataaca aaatataaaa accaataaaa atcataaaat agaaaatcaa caaaaatcat 8520
aaaatagaaa actagaaata gaagtaggta agaaggtata tgtgtcccct aagagacaca 8580
ccatatatag ctaagaatca atagataagc atagatcaaa gggctgaaca acccctgaat 8640
aataacaaaa tataaaaacc aataaaaatc ataaaataga aaaccacaaa tagaagtagt 8700
tcaaagggct ataaaacccc tgaatagtaa caaaatataa aactaataaa aatcaaacga 8760
ataccataat tggcaatcgg aagagatgta ggtacttaag cttcttaaaa gcagccgaac 8820
tcgctttgag atgtaggcgt agcacaccga actcttccat aattctccga acccacaggg 8880
acgtaggaga tgttcaaagt gactataaaa ccctgaacag taataaaata taaaattaat 8940
aatgagtacc ataattggca aatggaagag acgtaggtac taagcttctt aaaagcagcc 9000
gaactcactt tgagatgtag gcatagcata ccgaactctt ccacaattct ccgtacccat 9060
agggacgtag gagatgttat tttgttttta atatttcaaa aaaaaaaaaa aaaaaaaaaa 9120
aaaaaaaaaa aaaaaaaa 9138
<210> 52
<211> 10258
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 52
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aaatgagaca gagaggtcta gaaatatctg cacgtacggt tgattcgctg 420
ctcttgaatg gatgcaatag accagtcgac gtgttgtacg tagacgaggc gtttgcgtgc 480
cactctggaa cgttacttgc cttgatcgcc ttggtgagac caagactgaa agttgtactt 540
tgtggtgacc cgaagcagtg cggcttcttc aatatgatgc agatgaaagt caactacaat 600
cataacatct gcactcaagt gtaccacaaa agtatttcca ggcggtgtac actgcctgtg 660
actgccattg tgtcgtcgtt gcattacgaa ggcaaaatgc gcactacgaa tgagtacaac 720
atgccgattg tagtggacac tacgggctca acaaaacctg accctggaga cctcgtgtta 780
acgtgcttca gagggtgggt taaacaactg caaattgact atcgtggaca cgaggtcatg 840
acagcagccg catcccaagg gttaaccaga aaaggagttt acgcagttag gcaaaaagtt 900
aacgaaaacc cactctatgc atcaacatca gagcacgtca acgtactcct aacgcgtacg 960
gaaggtaaac tggtatggaa gacactctct ggtgacccgt ggataaagac gctgcagaac 1020
ccaccgaaag gaaacttcaa ggcaactatt aaggagtggg aggtggagca cgcatcgata 1080
atggcgggca tctgcagtca ccaagtgacc tttgacacgt tccaaaacaa agccaacgtt 1140
tgctgggcta agagcttggt ccctatcctc gaaacagcgg ggataaaact aaatgatagg 1200
cagtggtccc agataattca agctttcaaa gaagacaaag catactcacc cgaagtagcc 1260
ctgaatgaaa tatgcacgcg catgtatggg gtggatctag acagcgggct attctctaaa 1320
ccgttggtat ctgtgtatta cgcggataac cactgggata ataggccggg aggaaagatg 1380
ttcggattca accctgaggc agcgtccatt ctagaaagaa agtacccgtt tacaaaagga 1440
aagtggaaca tcaacaagca gatctgcgtg actaccagga ggatagaaga cttcaaccct 1500
accaccaaca ttataccggc caacaggaga ctaccacact cattagtggc cgaacaccgc 1560
ccagtaaaag gggaaagaat ggaatggctg gttaacaaga taaacggaca tcatgtgctc 1620
ctggttagcg gctataacct tgcactgcct actaagagag tcacctgggt agcgccacta 1680
ggtgtccgcg gagcggacta tacatacaac ctagagctgg gtctaccggc aacacttggt 1740
aggtatgacc tagtggtcat aaacatccac acaccttttc gcatacacca ttaccaacag 1800
tgcgtagatc acgcaatgaa actgcaaatg ctaggaggtg actcactgag actgctcaaa 1860
ccgggtggct ctctattgat cagagcatac ggttacgcag atagaaccag tgaacgagta 1920
atctgcgtac tgggacgtaa gtttagatcg tccagagcat tgaaaccacc atgtatcacc 1980
agtaatactg agatgttctt cctatttagc agttttgaca atggcagaag gaattttaca 2040
acgcatgtta tgaacaatca actgaacgca gcctttgtag gacaggccac ccgagcagga 2100
tgtgcaccat cgtaccgggt aaagcgcatg gacatcgcga agaacgatga agagtgcgtg 2160
gtcaacgccg ccaaccctcg cgggttaccg ggtgacggtg tttgcaaggc agtatataaa 2220
aaatggccgg agtcctttaa aaatagtgca acaccagtag gaaccgcaaa aacagttatg 2280
tgcggtacat atccagtaat ccatgccgta ggaccaaact tctcaaatta cacggagtcc 2340
gaaggggacc gggaattggc ggctgcctat cgagaagtcg caaaggaagt aactagactg 2400
ggagtaaata gcgtagctat acctctcctc tccacaggtg tatactcagg agggaaagac 2460
aggctaaccc agtcactgaa ccacctcttt acagccatgg actcgacgga tgcagacgtg 2520
gtcatctact gccgagacaa ggaatgggag aagaaaatat ctgaggccat acagatgcgg 2580
acccaagtgg agctgctgga tgagcacatc tccatagact gcgatgtcat tcgcgtgcac 2640
cctgacagta gtttggcagg tagaaaagga tacagcacca cggaaggcgc actgtattca 2700
tatctagaag ggacacgttt tcaccagacg gcagtggatg tggcagagat acatactatg 2760
tggccaaagc aaatagaggc caatgagcaa gtctgcctat atgccctggg ggaaagtatt 2820
gagtcaatca ggcagaaatg cccggtggat gatgcagatg catcatctcc cccgaaaacc 2880
gtcccgtgcc tttgccgtta tgccatgact cctgaacgcg tcacccgact tcgcatgaac 2940
catgtcacaa atataattgt gtgttcttca tttccccttc caaagtacaa gatagaagga 3000
gtgcaaaaag tcaaatgctc caaggtaatg ttatttgatc acaatgtgcc atcgcgcgta 3060
agtccaaggg aatacagatc ttcccaggag tctgtacggg aagtgagtat gacaacgtca 3120
ttgacgcata gtcagtttga tctaagcgcc gatggcgaga cactgcccgt cccgtcagac 3180
ctggatgctg acgccccagc cctagaaccg gccctagacg acggggcgat acatacgacc 3240
ggaaaccttg cggccgtgtc tgactgggta atgagcaccg tacccgtcgc gccgcctaga 3300
agaaggagag ggagaaacct gaccgtgata tgtgacgaga gagaagggaa tataacaccc 3360
atggctagcg tccgattctt tagagcagag cagtgtccga ccgtacaaga aacagcggag 3420
acgcgtgaca cagctatttc ctttcgggca ccgccaagta tcaccgtgga actgagccat 3480
ccaccgatct ccttcggagc accaagcgag acgttcccca tcacatttgg ggacttcaac 3540
gatggagaaa tcgaaagctt gtcttctgag ctactaactt tcggagactt cctacccggt 3600
gaagtggatg atttgacaga tagcgactgg tccacgtgct cagacacgga cgacgagtta 3660
tgactagaca gggcaggtgg gtatatattc tcgtcggaca ccggtccagg ccatttacaa 3720
cagaagtcgg tacgccagtc agtgctgccg gtaaacaccc tggaggaagt tcacgaggag 3780
aagtgttacc cacctaagct ggatgaatta aaggagcaac tactacttaa gaaactccag 3840
gagagtgcgt ccacggccaa tagaagcagg tatcaatcac gcaaagtgga aaatatgaaa 3900
gcaacaatca tccagagact aaagagaggc tgtaaactgt atttaatggc agagaccccg 3960
aaagtcccga cttatcggac cgtatacccg gcgcctgtgt actcgcctcc gatcaacgtc 4020
cgattgtcca atcccgagtc cgcagtggca gcatgtaatg agttcttagc tagaaactac 4080
ccaactgttt catcatacca aatcaccgat gagtatgatg catatctaga catggtggac 4140
gggtcggaga gttgcttgga ccgagcgaca ttcaatccgt caaaacttag gagctacccg 4200
aaacaacatg cttatcacgc gccctctatc agaagcgctg taccttcccc attccagaac 4260
acactacaga atgtactggc agcagccacg aaaaggaact gcaacgtcac acagatgagg 4320
gaattaccca ctttggactc agcagtattc aacgtggagt gttttaaaaa attcgcatgc 4380
aaccgagaat actgggaaga atttgctgcc agccctatca ggataacgac tgagaatcta 4440
acaacctatg tcactaaatt aaaggggcca aaagcagcag cgttgcttgc aagaacccat 4500
aatctgctgc cgctgcagga tgtaccaatg gataggttca cagtagatat gaaaagggac 4560
gtgaaggtaa ctcctggcac aaagcataca gaggaaaggc ctaaggtgca ggttatacag 4620
gcggctgaac ccttggcaac agcgtaccta tgtggaattc acagagaatt ggttaggaga 4680
ttgaacgccg tcctcctacc caacgtgcat acactatttg acatgtctgc cgaggacttc 4740
gatgccatta tagccgcaca ctttaagcca ggagacgccg ttttagaaac ggacatagcc 4800
tcctttgata agagccagga tgattcactt gcgcttaccg ccttaatgct gttagaagat 4860
ttgggagtgg atcactcctt gttggacctg atagaggctg cttttggaga gatttccagc 4920
tgtcacctgc cgacaggtac gcgcttcaag ttcggcgcta tgatgaaatc cggtatgttc 4980
ctaactctgt tcgtcaacac attgttaaat atcaccatcg ctagccgggt gttggaagat 5040
cgtctgacaa aatctgcatg cgcggccttc atcggcgacg acaacataat acatggtgtc 5100
gtctccgatg aattgatggc agccagatgc gctacttgga tgaacatgga agtgaagatc 5160
atagatgcag ttgtatccca gaaagctccc tacttttgtg gagggtttat actgcatgat 5220
actgtgacag gaacagcttg cagggtggcg gacccgctaa aaaggttatt taaactgggc 5280
aaaccgttag cggcaggtga cgaacaagac gaagacagaa ggcgggcgct ggctgatgaa 5340
gtaatcagat ggcaacgaac agggctaata gatgagctgg agaaagcggt gtactctagg 5400
tacgaagtgc agggtatatc agttgctgta atgtccatgg ccacctttgc aagctccaga 5460
tccaacttcg agaagctcag aggacccgtc ataaccttgt acggcggtcc taaataggta 5520
cgcactacag ctacctattt tgcaaaagcc gacagcaggt acctaaatac caatcagcca 5580
taatggagtt tatcccaacc caaactttct acaataggag gtaccagcct cgaccttgga 5640
ctccgcgccc tactatccaa gtcatcagac ccagaccgcg tccgcaaagg aaggccgggc 5700
aacttgccca gctgatctca gcagttaata aactgacaat gcgcgtggta cctcaacaga 5760
agccgcgcaa gaatcggaag aataagaagc aaaagcaaaa gcagcaggcg ccacgaaaca 5820
atacgaatca aaagaagcag ccccccaaaa agaaaccggt tcaaaagaaa aagaagccgg 5880
gccgcagaga gagaatgtgc atgaaaatcg aaaatgattg catcttcgaa gtcaagcatg 5940
aaggtaaggt aacaggttac gcgtgcttgg taggggacaa agtaatgaag ccagcacacg 6000
taaaggggac catcgataac gcggacctgg ccaaattggc cttcaagcgg tcatctaagt 6060
acgaccttga atgcgcgcag atacccgtgc acatgaagtc cgacgcttcg aagttcaccc 6120
atgagaaacc ggaggggtac tacaactggc accacggagc agtacagtac tcaggaggcc 6180
gattcaccat ccctacaggt gcgggcaaac caggggatag tggtagaccg atcttcgaca 6240
acaaggggcg cgtggtggcc atagttttag gaggagctaa tgaaggagcc cgtacagccc 6300
tctcggtggt gacctggaac aaagacatcg tcacgaaaat cacccctgag ggggccgaag 6360
agtggagtct ggccattcca gttatgtgcc tgctggcaaa taccacgttc ccctgctccc 6420
ggcccccttg cacaccctgc tgctacgaaa aagagccgga gaaaaccttg cgcatgcttg 6480
aagacaatgt catgagcccc gggtactatc agctgctaca agcatcctta acatgttctc 6540
cccgacgcca gcggcgcagt attaaggacc acttcaatgt ctataaagcc acaagaccgt 6600
acctagctca ctgtcccgac tgtggagaag ggcactcgtg ccatagtccc gtagcgctag 6660
aacgcatcag aaacgaagcg acagacggga cgttgaaaat ccaggtttcc ttgcaaatcg 6720
gaataaagac ggatgatagc catgattgga ccaagctgcg ttatatggac aatcacatgc 6780
cagcagacgc agagcgggcc gggctatttg taagaacgtc agcaccgtgc acgattactg 6840
gaacaatggg acacttcatt ctggcccgat gtccgaaagg agaaactctg acggtggggt 6900
tcactgacgg taggaagatc agtcactcat gtacgcaccc atttcaccat gaccctcctg 6960
tgataggccg ggaaaaattc cattcccgac cgcagcacgg tagggaacta ccttgcagca 7020
cgtacgcgca gagcaccgct gcaactgccg aggagataga ggtacacatg cccccagaca 7080
ccccagatcg cacattaatg tcacaacagt ccggcaatgt aaagatcaca gtcaatagtc 7140
agacggtgcg gtacaagtgc aattgtggtg actcaagtga aggattaacc actacagata 7200
aagtgattaa taactgcaag gtcgatcaat gccatgccgc ggtcaccaat cacaaaaaat 7260
ggcagtataa ttcccctctg gtcccgcgta atgctgaatt cggggaccgg aaaggaaaag 7320
ttcacattcc atttcctctg gcaaatgtga catgcagggt gcctaaagca agaaacccca 7380
ccgtgacgta cggaaaaaac caagtcatca tgttgctgta tcctgaccac ccaacgctcc 7440
tgtcctacag gaatatggga gaagaaccaa actatcaaga agagtgggtg acgcataaga 7500
aggagatcag gttaaccgtg ccgactgagg ggctcgaggt cacgtggggt aacaatgagc 7560
cgtacaagta ttggccgcag ttatccacaa acggtacagc ccacggccac ccgcatgaga 7620
taattctgta ttattatgag ctgtacccaa ctatgactgc ggtagttttg tcagtggcct 7680
cgttcatact cctgtcgatg gtgggtgtgg cagtggggat gtgcatgtgt gcacgacgca 7740
gatgcattac accgtacgaa ctgacaccag gagctaccgt ccctttcctg cttagcctaa 7800
tatgctgcat tagaacagct aaagcggcca cataccagga ggccgcggta tacctgtgga 7860
acgagcagca gcctttattt tggatgcaag cccttattcc gctggcagcc ctgattgtcc 7920
tatgtaactg tctgagactc ttaccatgct gttgtaaaat gttgactttt ttagccgtac 7980
tgagcgtcgg tgcccacact gtgagcgcgt acgaacacgt aacagtgatc ccgaacacgg 8040
tgggagtacc gtataagact ctagtcaaca gaccgggcta cagccccatg gtattggaga 8100
tggagcttct gtctgtcacc ttggaaccaa cgctatcgct tgattacatc acgtgcgagt 8160
ataaaaccgt tatcccgtct ccgtacgtga aatgctgcgg tacagcagag tgtaaggaca 8220
agagcctacc tgattacagc tgtaaggtct tcaccggcgt ctacccattc atgtggggcg 8280
gcgcctactg cttctgcgac accgaaaata cgcaattgag cgaagcacat gtggagaagt 8340
ccgaatcatg caaaacagaa tttgcatcag catacagggc tcataccgca tccgcatcag 8400
ctaagctccg cgtcctttac caaggaaata atatcactgt ggctgcttat gcaaacggcg 8460
accatgccgt cacagttaag gacgctaaat tcatagtggg gccaatgtct tcagcctgga 8520
cacctttcga caataaaatc gtggtgtaca aaggcgacgt ctacaacatg gactacccgc 8580
ccttcggcgc aggaagacca ggacaatttg gcgacatcca aagtcgcacg cctgagagcg 8640
aagacgtcta tgctaataca caactggtac tgcagagacc gtccgcgggt acggtgcacg 8700
tgccgtactc tcaggcacca tctggcttca agtattggct aaaagaacga ggggcgtcgc 8760
tgcagcacac agcaccattt ggctgtcaaa tagcaacaaa cccggtaaga gcgatgaact 8820
gcgccgtagg gaacatgcct atctccatcg acataccgga cgcggccttt accagggtcg 8880
tcgacgcgcc atctttaacg gacatgtcgt gtgaggtatc agcctgcacc cattcctcag 8940
actttggggg cgtagccatc attaaatatg cagccagtaa gaaaggcaag tgtgcagtgc 9000
actcgatgac taacgccgtc actattcggg aagctgaaat agaagtagaa gggaactctc 9060
agttgcaaat ctctttttcg acggccctag ccagcgccga atttcgcgta caagtctgtt 9120
ctacacaagt acactgtgca gccgagtgcc atccaccgaa agaccatata gtcaattacc 9180
cggcgtcaca caccaccctc ggggtccaag acatttccgc tacggcgatg tcatgggtgc 9240
agaagatcac gggaggtgtg ggactggttg tcgctgttgc agcactgatc ctaatcgtgg 9300
tgctatgcgt gtcgtttagc aggcactaac ttgacaacta ggtatgaagg catacgcgtc 9360
cctaaagaga cacaccgcat atagctagga atcaacagat aagtatagat ctaagggctg 9420
aacaacccct gaataacaaa atataaaaat caacaaaaat cataaaatag aaaactagaa 9480
atagaagtag gtaagaaggt atatgtgtcc cctaagagac acaccatata tagctaagaa 9540
tcaatagata agcatagatc aaagggctga acaacccctg aataataaca aaatataaaa 9600
accaataaaa atcataaaat agaaaatcaa caaaaatcat aaaatagaaa actagaaata 9660
gaagtaggta agaaggtata tgtgtcccct aagagacaca ccatatatag ctaagaatca 9720
atagataagc atagatcaaa gggctgaaca acccctgaat aataacaaaa tataaaaacc 9780
aataaaaatc ataaaataga aaaccacaaa tagaagtagt tcaaagggct ataaaacccc 9840
tgaatagtaa caaaatataa aactaataaa aatcaaacga ataccataat tggcaatcgg 9900
aagagatgta ggtacttaag cttcttaaaa gcagccgaac tcgctttgag atgtaggcgt 9960
agcacaccga actcttccat aattctccga acccacaggg acgtaggaga tgttcaaagt 10020
gactataaaa ccctgaacag taataaaata taaaattaat aatgagtacc ataattggca 10080
aatggaagag acgtaggtac taagcttctt aaaagcagcc gaactcactt tgagatgtag 10140
gcatagcata ccgaactctt ccacaattct ccgtacccat agggacgtag gagatgttat 10200
tttgttttta atatttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 10258
<210> 53
<211> 3137
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 53
atggctgcgt gagacacacg tagcctacca gtttcttact gctctactct gcaaagcaag 60
agattaataa cccatcatgg attctgtgta cgtggatata gacgctgaca gcgccttttt 120
gaaggccctg caacgtgcgt accccatgtt tgaggtggaa cctaggcagg tcacatcaaa 180
tgaccatgct aatgctagag cgttctcgca tctagccata aaactaatag agcaggaaat 240
tgatcccgac tcaaccatcc tggatatagg tagtgcgcca gcaaggagga tgatgtcgga 300
caggaagtac cactgcgttt gcccgatgcg cagcgcagaa gatcccgaga gactcgctaa 360
ttatgcgaga aagctcgcat ctgccgcagg aaaagtcctg gacagaaaca tttctggaaa 420
gatcggggac ttacaagagg tgatggccgt gccagacacg gagacgccaa cattttgcct 480
acacacagat gtctcatgta gacagagagc agacgtcgcg atataccaag acgtctatgc 540
tgtacatgca cccacgtcgc tatatcacca ggcgattaaa ggagtccgag tggcgtactg 600
ggtagggttc gacacaaccc cgttcatgta caacgctatg gcgggtgcct acccctcata 660
ctcgacaaat tgggcggatg agcaggtact gaaggctaag aacataggat tatgttcaac 720
agacctgaca gaaggtagac gaggcaaatt gtctatcatg agagggaaaa agctaaaacc 780
gtgcgaccgt gtgctgttct cagtagggtc aacgctttac ccggaaagcc gcatgctact 840
taagagctgg cacctaccat cggtgttcca tctaaagggc aagcttagct tcacatgccg 900
ctgtgacaca gtggtttcgt gtgagggcta cgtcgttaag agaataacga tgagcccagg 960
cctttatgga aaaaccacgg ggtatgcggt aacccaccac gcagacggat tcttgatgtg 1020
caagactacc gacacggtag acggtgaaag agtgtcattc tcggtgtgca cgtacgtgcc 1080
ggcgaccatt tgtgatcaaa tgaccggcat ccttgctaca gaagtcacgc cggaggatgc 1140
acagaagctg ttggtggggc tgaaccagag aatagtggtt aacggcagaa cgcaacggaa 1200
cacgaacacc atgaagaact acctgcttcc cgtggtcgcc caggccttca gtaagtgggc 1260
gaaggagtgc cggaaggaca tggaagatga gaagcttttg ggggtcagag aaagaacact 1320
gacctgctgc tgtctgtggg catttaagaa gcagaaaaca cacacggtct acaagaggcc 1380
tgatacccag tcaatccaga aggttcaggc cgaattcgac agctttgtag taccaggcct 1440
gtggtcgtcc gggttgtcaa tcccgttgag gactagaatc aagtggctgt tacgcaaggt 1500
gccgaaagca gacctgatcc catatagcgg aaatgcccaa gaagcccagg atgctgaaaa 1560
agaagcagag gaagaacgag aagcagaact gactcatgag gctctaccac ccctacaggc 1620
agcacaggaa gatgtccagg tcgaaatcga cgtggaacaa cttgaggata gagctggtgc 1680
tggaataata gagactccga gaggcgctat taaagttact gcccaactaa cggaccacgt 1740
cgtgggggag tacctggtac tttccccgca gaccgtatta cgcagccaga agctcagcct 1800
gatccacgct ttagcggagc aagtgaagac gtgtacgcat agcggacgag cagggaggta 1860
tgcggtcgaa gcgtacgatg gccgagtcct agtgccctca ggctatgcaa tttcgcccga 1920
agacttccag agtctaagcg aaagcgcaac gatggtgtac aacgaaagag agttcgtaaa 1980
cagaaagtta caccacattg cgatgcacgg accagctctg aacactgacg aagagtcgta 2040
tgagcttgtg agggcagaga ggacagaaca cgagtacgtc tacgacgtgg accagagaag 2100
atgctgcaag aaggaagaag ctgcaggatt ggtactggtg ggcgacttga ctaatccgcc 2160
ctaccacgaa ttcgcatacg aagggctaaa aattcgcccc gcttgtccat ataaaattgc 2220
agtcatagga gtcttcgggg taccaggatc tggtaagtca gccattatca agaacctagt 2280
taccaggcaa gacctggtga ctagcggaaa gaaagaaaac tgccaagaaa tcagcaccga 2340
cgtgatgaga cagagaggtc tagaaatatc tgcacgtacg gttgattcgc tgctcttgaa 2400
tggatgcaat agaccagtcg acgtgttgta cgtagacgag gcgtttgcgt gccactctgg 2460
aacgttactt gccttgatcg ccttggtgag accaagactg aaagttgtac tttgtggtga 2520
cccgaagcag tgcggcttct tcaatatgat gcagatgaaa gtcaactaca atcataacat 2580
ctgcactcaa gtgtaccaca aaagtatttc caggcggtgt acactgcctg tgactgccat 2640
tgtgtcgtcg ttgcattacg aaggcaaaat gcgcactacg aatgagtaca acatgccgtt 2700
caaagggcta taaaacccct gaatagtaac aaaatataaa actaataaaa atcaaacgaa 2760
taccataatt ggcaatcgga agagatgtag gtacttaagc ttcttaaaag cagccgaact 2820
cgctttgaga tgtaggcgta gcacaccgaa ctcttccata attctccgaa cccacaggga 2880
cgtaggagat gttcaaagtg actataaaac cctgaacagt aataaaatat aaaattaata 2940
atgagtacca taattggcaa atggaagaga cgtaggtact aagcttctta aaagcagccg 3000
aactcacttt gagatgtagg catagcatac cgaactcttc cacaattctc cgtacccata 3060
gggacgtagg agatgttatt ttgtttttaa tatttcaaaa aaaaaaaaaa aaaaaaaaaa 3120
aaaaaaaaaa aaaaaaa 3137
<210> 54
<211> 7168
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 54
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
caagaatagt tacagaaaaa cagaaacatt ctgttgtcat cacaacacac atatatcata 3060
aagctaaaca cacaaaagct tggtgtccta ggccccctag agctgtccct tacacacata 3120
gtcatgtgac taattatatg ccagaaacag gtgacgtgac aacagccata gtccgcagaa 3180
acactataac aactgctggg cccagtgatc tatatgtgca tgtaggtaac ttaatatata 3240
gaaacttaca tctgttcaat tctgaaatgc atgattcaat tttgatttca tactcttctg 3300
atttaatcat ataccgcaca aacactatag gtgatgatta tattcccaat tgtaactgca 3360
ctgaggctac ttattattgt agacacaaaa ataggtatta cccaataaaa gttactccac 3420
atgattggta tgaaatacaa gagagtgaat attaccccaa acacatccaa tacaacctat 3480
taattggtga aggaccatgt gaacctggtg attgtggtgg aaaacttctt tgtagacatg 3540
gtgtcattgg cataatcaca gcaggtggtg aaggtcatgt agcatttata gatcttagac 3600
aatttcactg tgctgaggaa caaggcataa ctgattacat acacatgttg ggagaggctt 3660
ttggcaatgg ttttgtagat agtgttaaag aacaaataaa tgcaataaat ccaatcaata 3720
acattagtaa gaaggttatt aagtggctac ttagaataat ctcggctatg gttattataa 3780
tcagaaactc ctctgaccct caaacgatca tagcaacctt gacactaatt ggttgcaatg 3840
gttcaccatg gagatttctc aaagaaaagt tttgcaaatg gacccaatta acttatatcc 3900
acaaagagtc tgattcatgg cttaagaaat tcactgaaat gtgtaatgct gcacgtggtc 3960
ttgaatggat tggtaataaa atttcaaaat ttatagattg gatgaaatct atgctacccc 4020
aggcccaatt gaaagttaaa tacttgaatg aaataaagaa actcagtttg cttgaaaaac 4080
agattgaaaa tctacgtgcg gcagatagtg caacacaaga gaaaatcaaa tgtgaaattg 4140
acaccctaca tgatctatcg tgcaaatttc ttcctttgta tgcacatgag gcaaaaagaa 4200
tcaaagtgct ttataataaa tgttccaata taattaaaca aagaaagaga agtgaaccgg 4260
tggcggtgat gatacatgga ccacccggta ctggtaaatc tataacaact aacttcttgg 4320
ctagaatgat aacaaatgaa agtgatgtgt actcattacc tccagatccc aaatattttg 4380
atggttatga caatcagagt gttgtaatca tggatgatat tatgcaaaat ccagatggag 4440
aagacatgac actattttgc caaatggttt caagtgttac atttatacca cccatggctg 4500
atttgcctga caagggtaaa ccatttgatt caagatttat cttatgtagt actaaccact 4560
cgcttttagc cccacctact atatcttcat tacccgcaat gaatagaaga tttttctttg 4620
acttagatat tgtagttcat gacaattata aagatacaca agggaaatta gatgtatcca 4680
aagcttttcg accttgtaat gttaacacca aaattggcaa tgcaagatgt tgtccatttg 4740
tatgtggtaa ggcagtgaca ttcaaagatc gcagcacttg ctcaacatac accttagctc 4800
aagtttacaa tcacattttg gaagaagaca aaagaaggag acaggtggtg gatgtcatgt 4860
ctgcaatttt ccaaggacca atttctttag acgctccacc accaccagct atagcagatc 4920
tgttacaatc agttagaaca cctgaggtaa tcaagtactg tcaagataat aaatggatca 4980
ttccagcaga gtgccaagtg gaaagagact taaatatagc cagtagcata atagctatta 5040
tagcaaatat aataagtata gctggcatta tacttgtaat ttataaattg ttttgttcat 5100
tacaaggacc atactcaggt gaacctaaac ctaaaaccaa agtacctgaa agaagagtag 5160
ttgctcaagg tccagaagaa gaatttggaa ggtcaattct caaaaacaat acttgtgtga 5220
ttactacagg taatggaaaa tttacaggtc ttggtataca tgacagaatt ctaatcatcc 5280
caacacatgc tgatccaggt agagaggtcc aagttaatgg tgtccacact aaggttctag 5340
actcatatga tctttataat agagatggag ttaaacttga aataacggtc atacaattag 5400
atagaaatga aaaatttagg gacattagaa agtatatacc tgaaacagaa gacgattatc 5460
cagaatgcaa tttggcactt tcagctaatc aagatgaacc aactataatt aaagtaggag 5520
atgtagtgtc ctatggcaat attttgctta gtggaaatca aacagccaga atgcttaaat 5580
ataattaccc cacaaaatct gggtattgtg gaggggtact atataaaatt ggtcaaattc 5640
taggtattca tgtgggtgga aatggaaggg atggtttttc agccatgtta cttagatcat 5700
actttacaga tactcagggc caaattaaag tcaataagca tgctactgaa tgtggtcttc 5760
caactataca cactcctagc aaaaccaaac ttcagcctag tgtattttat gatgtcttcc 5820
caggttctaa ggaaccagct gtgctcacag ataatgaccc tagattggaa gttaatttta 5880
aagaagcttt attttctaaa tataaaggta atgtggaatg taatttgaat gaacatatgg 5940
aaattgctat tgcccattac tcagcacaat taatgacact agatattgat tccaggccaa 6000
tagcattgga agatagcgtg tttggaatag aaggacttga ggctttagat ctaaacacca 6060
gtgcagggtt tccttatgtc acaatgggta ttaaaaagag agatttaata aataacaaaa 6120
caaaagatat atccaggctt aaagaggctc tagataaata tggagttgac ttacccatga 6180
tcactttctt aaaagacgag cttaggaaaa aggagaaaat ttcaacaggt aaaactagag 6240
ttatagaagc aagtagtata aatgacacaa tattatttag aactactttt ggcaatttgt 6300
tctctaagtt tcatttaaac ccaggcgttg ttactggctc tgcagtaggg tgtgaccctg 6360
agactttctg gtctaaaatc ccagttatgc ttgatggaga ttgtataatg gcttttgact 6420
atacaaatta tgatggtagt atacaccctg tctggtttca agctctgaaa aaagttcttg 6480
aaaatttatc tttccaatct aatttaattg atagattgtg ttattccaag cacttgttta 6540
aatcaacata ttatgaagtg gcaggtggag ttccttctgg gtgttctgga accagtatat 6600
tcaatactat gattaataac attataataa gaacactagt tctagatgca tacaaaaata 6660
ttgatctgga caagcttaaa ataattgcat atggtgatga tgtgattttc tcttataaat 6720
atactctaga tatggaagct attgctaatg aaggaaagaa atatggactt acaataacac 6780
cagcagataa gtccaatgaa ttcaagaaac ttgattatag taatgtgact tttcttaaac 6840
gtggttttaa gcaagatgaa agacatacat tccttattca tcctacattc ccagtggaag 6900
agatacatga atcaattaga tggaccaaga aaccttcaca gatgcaagaa catgtgctat 6960
cattatgtca cctgatgtgg cacaatggac gtaaggtgta tgaagatttc tctagtaaga 7020
tacgcagtgt cagcgctgga cgtgcactgt atatcccacc ttatgatctg ttgaaacatg 7080
aatggtatga aaaattttag atatagaaat aatgaatgaa tgattcttta attctataaa 7140
aaaaaaaaaa aaaaaaaaaa aaaaaaaa 7168
<210> 55
<211> 6973
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 55
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttatctc 1920
ttgttgtacc atgggtgagt gccagccact tcaggttaac tgcagataat aaatactcca 1980
tggctggtta tatcacatgt tggtaccaaa ctaatttagt agtgccccca agtacgccac 2040
agactgctga tatgctgtgt tttgtttctg catgtaaaga tttttgtcta cgaatggcaa 2100
gggatacaga tttacacata caaagtggtc caatagagca aaatccagta gaaaactaca 2160
ttgatgaagt tttaaatgaa gttttagtag tgccgaatat aaaagaaagt catcacacta 2220
catcaaactc tgccccactt ttagatgctg cagagacggg acacaccagt aatgttcaac 2280
cagaagatgc tatagagaca aggtatgtta taacatcaca aacaagagat gagatgagta 2340
tagaaagttt ccttggtaga tctggttgtg tccacatctc aagaataaag gttgattaca 2400
ctgactataa tggacaggac ataaatttca caaaatggaa aatcacacta caggaaatgg 2460
cacagattag gagaaaattt gaattgttta catatgtcag gtttgactca gaaataacct 2520
tggtgccttg tattgctggt agaggagacg acattggaca tattgtaatg caatatatgt 2580
atgttcctcc aggagctcca attccttcaa aaagaaacga tttctcatgg caatcaggca 2640
ccaatatgtc aatattctgg caacatggac agccatttcc tagattttct ttaccatttc 2700
ttagcattgc atcagcttat tatatgtttt atgatggata tgatggagac aacacttctt 2760
ccaagtatgg tagcgtagtt actaatgata tgggtactat atgctcaaga atagttacag 2820
aaaaacagaa acattctgtt gtcatcacaa cacacatata tcataaagct aaacacacaa 2880
aagcttggtg tcctaggccc cctagagctg tcccttacac acatagtcat gtgactaatt 2940
atatgccaga aacaggtgac gtgacaacag ccatagtccg cagaaacact ataacaactg 3000
ctgggcccag tgatctatat gtgcatgtag gtaacttaat atatagaaac ttacatctgt 3060
tcaattctga aatgcatgat tcaattttga tttcatactc ttctgattta atcatatacc 3120
gcacaaacac tataggtgat gattatattc ccaattgtaa ctgcactgag gctacttatt 3180
attgtagaca caaaaatagg tattacccaa taaaagttac tccacatgat tggtatgaaa 3240
tacaagagag tgaatattac cccaaacaca tccaatacaa cctattaatt ggtgaaggac 3300
catgtgaacc tggtgattgt ggtggaaaac ttctttgtag acatggtgtc attggcataa 3360
tcacagcagg tggtgaaggt catgtagcat ttatagatct tagacaattt cactgtgctg 3420
aggaacaagg cataactgat tacatacaca tgttgggaga ggcttttggc aatggttttg 3480
tagatagtgt taaagaacaa ataaatgcaa taaatccaat caataacatt agtaagaagg 3540
ttattaagtg gctacttaga ataatctcgg ctatggttat tataatcaga aactcctctg 3600
accctcaaac gatcatagca accttgacac taattggttg caatggttca ccatggagat 3660
ttctcaaaga aaagttttgc aaatggaccc aattaactta tatccacaaa gagtctgatt 3720
catggcttaa gaaattcact gaaatgtgta atgctgcacg tggtcttgaa tggattggta 3780
ataaaatttc aaaatttata gattggatga aatctatgct accccaggcc caattgaaag 3840
ttaaatactt gaatgaaata aagaaactca gtttgcttga aaaacagatt gaaaatctac 3900
gtgcggcaga tagtgcaaca caagagaaaa tcaaatgtga aattgacacc ctacatgatc 3960
tatcgtgcaa atttcttcct ttgtatgcac atgaggcaaa aagaatcaaa gtgctttata 4020
ataaatgttc caatataatt aaacaaagaa agagaagtga accggtggcg gtgatgatac 4080
atggaccacc cggtactggt aaatctataa caactaactt cttggctaga atgataacaa 4140
atgaaagtga tgtgtactca ttacctccag atcccaaata ttttgatggt tatgacaatc 4200
agagtgttgt aatcatggat gatattatgc aaaatccaga tggagaagac atgacactat 4260
tttgccaaat ggtttcaagt gttacattta taccacccat ggctgatttg cctgacaagg 4320
gtaaaccatt tgattcaaga tttatcttat gtagtactaa ccactcgctt ttagccccac 4380
ctactatatc ttcattaccc gcaatgaata gaagattttt ctttgactta gatattgtag 4440
ttcatgacaa ttataaagat acacaaggga aattagatgt atccaaagct tttcgacctt 4500
gtaatgttaa caccaaaatt ggcaatgcaa gatgttgtcc atttgtatgt ggtaaggcag 4560
tgacattcaa agatcgcagc acttgctcaa catacacctt agctcaagtt tacaatcaca 4620
ttttggaaga agacaaaaga aggagacagg tggtggatgt catgtctgca attttccaag 4680
gaccaatttc tttagacgct ccaccaccac cagctatagc agatctgtta caatcagtta 4740
gaacacctga ggtaatcaag tactgtcaag ataataaatg gatcattcca gcagagtgcc 4800
aagtggaaag agacttaaat atagccagta gcataatagc tattatagca aatataataa 4860
gtatagctgg cattatactt gtaatttata aattgttttg ttcattacaa ggaccatact 4920
caggtgaacc taaacctaaa accaaagtac ctgaaagaag agtagttgct caaggtccag 4980
aagaagaatt tggaaggtca attctcaaaa acaatacttg tgtgattact acaggtaatg 5040
gaaaatttac aggtcttggt atacatgaca gaattctaat catcccaaca catgctgatc 5100
caggtagaga ggtccaagtt aatggtgtcc acactaaggt tctagactca tatgatcttt 5160
ataatagaga tggagttaaa cttgaaataa cggtcataca attagataga aatgaaaaat 5220
ttagggacat tagaaagtat atacctgaaa cagaagacga ttatccagaa tgcaatttgg 5280
cactttcagc taatcaagat gaaccaacta taattaaagt aggagatgta gtgtcctatg 5340
gcaatatttt gcttagtgga aatcaaacag ccagaatgct taaatataat taccccacaa 5400
aatctgggta ttgtggaggg gtactatata aaattggtca aattctaggt attcatgtgg 5460
gtggaaatgg aagggatggt ttttcagcca tgttacttag atcatacttt acagatactc 5520
agggccaaat taaagtcaat aagcatgcta ctgaatgtgg tcttccaact atacacactc 5580
ctagcaaaac caaacttcag cctagtgtat tttatgatgt cttcccaggt tctaaggaac 5640
cagctgtgct cacagataat gaccctagat tggaagttaa ttttaaagaa gctttatttt 5700
ctaaatataa aggtaatgtg gaatgtaatt tgaatgaaca tatggaaatt gctattgccc 5760
attactcagc acaattaatg acactagata ttgattccag gccaatagca ttggaagata 5820
gcgtgtttgg aatagaagga cttgaggctt tagatctaaa caccagtgca gggtttcctt 5880
atgtcacaat gggtattaaa aagagagatt taataaataa caaaacaaaa gatatatcca 5940
ggcttaaaga ggctctagat aaatatggag ttgacttacc catgatcact ttcttaaaag 6000
acgagcttag gaaaaaggag aaaatttcaa caggtaaaac tagagttata gaagcaagta 6060
gtataaatga cacaatatta tttagaacta cttttggcaa tttgttctct aagtttcatt 6120
taaacccagg cgttgttact ggctctgcag tagggtgtga ccctgagact ttctggtcta 6180
aaatcccagt tatgcttgat ggagattgta taatggcttt tgactataca aattatgatg 6240
gtagtataca ccctgtctgg tttcaagctc tgaaaaaagt tcttgaaaat ttatctttcc 6300
aatctaattt aattgataga ttgtgttatt ccaagcactt gtttaaatca acatattatg 6360
aagtggcagg tggagttcct tctgggtgtt ctggaaccag tatattcaat actatgatta 6420
ataacattat aataagaaca ctagttctag atgcatacaa aaatattgat ctggacaagc 6480
ttaaaataat tgcatatggt gatgatgtga ttttctctta taaatatact ctagatatgg 6540
aagctattgc taatgaagga aagaaatatg gacttacaat aacaccagca gataagtcca 6600
atgaattcaa gaaacttgat tatagtaatg tgacttttct taaacgtggt tttaagcaag 6660
atgaaagaca tacattcctt attcatccta cattcccagt ggaagagata catgaatcaa 6720
ttagatggac caagaaacct tcacagatgc aagaacatgt gctatcatta tgtcacctga 6780
tgtggcacaa tggacgtaag gtgtatgaag atttctctag taagatacgc agtgtcagcg 6840
ctggacgtgc actgtatatc ccaccttatg atctgttgaa acatgaatgg tatgaaaaat 6900
tttagatata gaaataatga atgaatgatt ctttaattct ataaaaaaaa aaaaaaaaaa 6960
aaaaaaaaaa aaa 6973
<210> 56
<211> 6972
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 56
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca acttatctct 1920
tgttgtacca tgggtgagtg ccagccactt caggttaact gcagataata aatactccat 1980
ggctggttat atcacatgtt ggtaccaaac taatttagta gtgcccccaa gtacgccaca 2040
gactgctgat atgctgtgtt ttgtttctgc atgtaaagat ttttgtctac gaatggcaag 2100
ggatacagat ttacacatac aaagtggtcc aatagagcaa aatccagtag aaaactacat 2160
tgatgaagtt ttaaatgaag ttttagtagt gccgaatata aaagaaagtc atcacactac 2220
atcaaactct gccccacttt tagatgctgc agagacggga cacaccagta atgttcaacc 2280
agaagatgct atagagacaa ggtatgttat aacatcacaa acaagagatg agatgagtat 2340
agaaagtttc cttggtagat ctggttgtgt ccacatctca agaataaagg ttgattacac 2400
tgactataat ggacaggaca taaatttcac aaaatggaaa atcacactac aggaaatggc 2460
acagattagg agaaaatttg aattgtttac atatgtcagg tttgactcag aaataacctt 2520
ggtgccttgt attgctggta gaggagacga cattggacat attgtaatgc aatatatgta 2580
tgttcctcca ggagctccaa ttccttcaaa aagaaacgat ttctcatggc aatcaggcac 2640
caatatgtca atattctggc aacatggaca gccatttcct agattttctt taccatttct 2700
tagcattgca tcagcttatt atatgtttta tgatggatat gatggagaca acacttcttc 2760
caagtatggt agcgtagtta ctaatgatat gggtactata tgctcaagaa tagttacaga 2820
aaaacagaaa cattctgttg tcatcacaac acacatatat cataaagcta aacacacaaa 2880
agcttggtgt cctaggcccc ctagagctgt cccttacaca catagtcatg tgactaatta 2940
tatgccagaa acaggtgacg tgacaacagc catagtccgc agaaacacta taacaactgc 3000
tgggcccagt gatctatatg tgcatgtagg taacttaata tatagaaact tacatctgtt 3060
caattctgaa atgcatgatt caattttgat ttcatactct tctgatttaa tcatataccg 3120
cacaaacact ataggtgatg attatattcc caattgtaac tgcactgagg ctacttatta 3180
ttgtagacac aaaaataggt attacccaat aaaagttact ccacatgatt ggtatgaaat 3240
acaagagagt gaatattacc ccaaacacat ccaatacaac ctattaattg gtgaaggacc 3300
atgtgaacct ggtgattgtg gtggaaaact tctttgtaga catggtgtca ttggcataat 3360
cacagcaggt ggtgaaggtc atgtagcatt tatagatctt agacaatttc actgtgctga 3420
ggaacaaggc ataactgatt acatacacat gttgggagag gcttttggca atggttttgt 3480
agatagtgtt aaagaacaaa taaatgcaat aaatccaatc aataacatta gtaagaaggt 3540
tattaagtgg ctacttagaa taatctcggc tatggttatt ataatcagaa actcctctga 3600
ccctcaaacg atcatagcaa ccttgacact aattggttgc aatggttcac catggagatt 3660
tctcaaagaa aagttttgca aatggaccca attaacttat atccacaaag agtctgattc 3720
atggcttaag aaattcactg aaatgtgtaa tgctgcacgt ggtcttgaat ggattggtaa 3780
taaaatttca aaatttatag attggatgaa atctatgcta ccccaggccc aattgaaagt 3840
taaatacttg aatgaaataa agaaactcag tttgcttgaa aaacagattg aaaatctacg 3900
tgcggcagat agtgcaacac aagagaaaat caaatgtgaa attgacaccc tacatgatct 3960
atcgtgcaaa tttcttcctt tgtatgcaca tgaggcaaaa agaatcaaag tgctttataa 4020
taaatgttcc aatataatta aacaaagaaa gagaagtgaa ccggtggcgg tgatgataca 4080
tggaccaccc ggtactggta aatctataac aactaacttc ttggctagaa tgataacaaa 4140
tgaaagtgat gtgtactcat tacctccaga tcccaaatat tttgatggtt atgacaatca 4200
gagtgttgta atcatggatg atattatgca aaatccagat ggagaagaca tgacactatt 4260
ttgccaaatg gtttcaagtg ttacatttat accacccatg gctgatttgc ctgacaaggg 4320
taaaccattt gattcaagat ttatcttatg tagtactaac cactcgcttt tagccccacc 4380
tactatatct tcattacccg caatgaatag aagatttttc tttgacttag atattgtagt 4440
tcatgacaat tataaagata cacaagggaa attagatgta tccaaagctt ttcgaccttg 4500
taatgttaac accaaaattg gcaatgcaag atgttgtcca tttgtatgtg gtaaggcagt 4560
gacattcaaa gatcgcagca cttgctcaac atacacctta gctcaagttt acaatcacat 4620
tttggaagaa gacaaaagaa ggagacaggt ggtggatgtc atgtctgcaa ttttccaagg 4680
accaatttct ttagacgctc caccaccacc agctatagca gatctgttac aatcagttag 4740
aacacctgag gtaatcaagt actgtcaaga taataaatgg atcattccag cagagtgcca 4800
agtggaaaga gacttaaata tagccagtag cataatagct attatagcaa atataataag 4860
tatagctggc attatacttg taatttataa attgttttgt tcattacaag gaccatactc 4920
aggtgaacct aaacctaaaa ccaaagtacc tgaaagaaga gtagttgctc aaggtccaga 4980
agaagaattt ggaaggtcaa ttctcaaaaa caatacttgt gtgattacta caggtaatgg 5040
aaaatttaca ggtcttggta tacatgacag aattctaatc atcccaacac atgctgatcc 5100
aggtagagag gtccaagtta atggtgtcca cactaaggtt ctagactcat atgatcttta 5160
taatagagat ggagttaaac ttgaaataac ggtcatacaa ttagatagaa atgaaaaatt 5220
tagggacatt agaaagtata tacctgaaac agaagacgat tatccagaat gcaatttggc 5280
actttcagct aatcaagatg aaccaactat aattaaagta ggagatgtag tgtcctatgg 5340
caatattttg cttagtggaa atcaaacagc cagaatgctt aaatataatt accccacaaa 5400
atctgggtat tgtggagggg tactatataa aattggtcaa attctaggta ttcatgtggg 5460
tggaaatgga agggatggtt tttcagccat gttacttaga tcatacttta cagatactca 5520
gggccaaatt aaagtcaata agcatgctac tgaatgtggt cttccaacta tacacactcc 5580
tagcaaaacc aaacttcagc ctagtgtatt ttatgatgtc ttcccaggtt ctaaggaacc 5640
agctgtgctc acagataatg accctagatt ggaagttaat tttaaagaag ctttattttc 5700
taaatataaa ggtaatgtgg aatgtaattt gaatgaacat atggaaattg ctattgccca 5760
ttactcagca caattaatga cactagatat tgattccagg ccaatagcat tggaagatag 5820
cgtgtttgga atagaaggac ttgaggcttt agatctaaac accagtgcag ggtttcctta 5880
tgtcacaatg ggtattaaaa agagagattt aataaataac aaaacaaaag atatatccag 5940
gcttaaagag gctctagata aatatggagt tgacttaccc atgatcactt tcttaaaaga 6000
cgagcttagg aaaaaggaga aaatttcaac aggtaaaact agagttatag aagcaagtag 6060
tataaatgac acaatattat ttagaactac ttttggcaat ttgttctcta agtttcattt 6120
aaacccaggc gttgttactg gctctgcagt agggtgtgac cctgagactt tctggtctaa 6180
aatcccagtt atgcttgatg gagattgtat aatggctttt gactatacaa attatgatgg 6240
tagtatacac cctgtctggt ttcaagctct gaaaaaagtt cttgaaaatt tatctttcca 6300
atctaattta attgatagat tgtgttattc caagcacttg tttaaatcaa catattatga 6360
agtggcaggt ggagttcctt ctgggtgttc tggaaccagt atattcaata ctatgattaa 6420
taacattata ataagaacac tagttctaga tgcatacaaa aatattgatc tggacaagct 6480
taaaataatt gcatatggtg atgatgtgat tttctcttat aaatatactc tagatatgga 6540
agctattgct aatgaaggaa agaaatatgg acttacaata acaccagcag ataagtccaa 6600
tgaattcaag aaacttgatt atagtaatgt gacttttctt aaacgtggtt ttaagcaaga 6660
tgaaagacat acattcctta ttcatcctac attcccagtg gaagagatac atgaatcaat 6720
tagatggacc aagaaacctt cacagatgca agaacatgtg ctatcattat gtcacctgat 6780
gtggcacaat ggacgtaagg tgtatgaaga tttctctagt aagatacgca gtgtcagcgc 6840
tggacgtgca ctgtatatcc caccttatga tctgttgaaa catgaatggt atgaaaaatt 6900
ttagatatag aaataatgaa tgaatgattc tttaattcta taaaaaaaaa aaaaaaaaaa 6960
aaaaaaaaaa aa 6972
<210> 57
<211> 6931
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 57
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
ctagaaactt acatctgttc aattctgaaa tgcatgattc aattttgatt tcatactctt 3060
ctgatttaat catataccgc acaaacacta taggtgatga ttatattccc aattgtaact 3120
gcactgaggc tacttattat tgtagacaca aaaataggta ttacccaata aaagttactc 3180
cacatgattg gtatgaaata caagagagtg aatattaccc caaacacatc caatacaacc 3240
tattaattgg tgaaggacca tgtgaacctg gtgattgtgg tggaaaactt ctttgtagac 3300
atggtgtcat tggcataatc acagcaggtg gtgaaggtca tgtagcattt atagatctta 3360
gacaatttca ctgtgctgag gaacaaggca taactgatta catacacatg ttgggagagg 3420
cttttggcaa tggttttgta gatagtgtta aagaacaaat aaatgcaata aatccaatca 3480
ataacattag taagaaggtt attaagtggc tacttagaat aatctcggct atggttatta 3540
taatcagaaa ctcctctgac cctcaaacga tcatagcaac cttgacacta attggttgca 3600
atggttcacc atggagattt ctcaaagaaa agttttgcaa atggacccaa ttaacttata 3660
tccacaaaga gtctgattca tggcttaaga aattcactga aatgtgtaat gctgcacgtg 3720
gtcttgaatg gattggtaat aaaatttcaa aatttataga ttggatgaaa tctatgctac 3780
cccaggccca attgaaagtt aaatacttga atgaaataaa gaaactcagt ttgcttgaaa 3840
aacagattga aaatctacgt gcggcagata gtgcaacaca agagaaaatc aaatgtgaaa 3900
ttgacaccct acatgatcta tcgtgcaaat ttcttccttt gtatgcacat gaggcaaaaa 3960
gaatcaaagt gctttataat aaatgttcca atataattaa acaaagaaag agaagtgaac 4020
cggtggcggt gatgatacat ggaccacccg gtactggtaa atctataaca actaacttct 4080
tggctagaat gataacaaat gaaagtgatg tgtactcatt acctccagat cccaaatatt 4140
ttgatggtta tgacaatcag agtgttgtaa tcatggatga tattatgcaa aatccagatg 4200
gagaagacat gacactattt tgccaaatgg tttcaagtgt tacatttata ccacccatgg 4260
ctgatttgcc tgacaagggt aaaccatttg attcaagatt tatcttatgt agtactaacc 4320
actcgctttt agccccacct actatatctt cattacccgc aatgaataga agatttttct 4380
ttgacttaga tattgtagtt catgacaatt ataaagatac acaagggaaa ttagatgtat 4440
ccaaagcttt tcgaccttgt aatgttaaca ccaaaattgg caatgcaaga tgttgtccat 4500
ttgtatgtgg taaggcagtg acattcaaag atcgcagcac ttgctcaaca tacaccttag 4560
ctcaagttta caatcacatt ttggaagaag acaaaagaag gagacaggtg gtggatgtca 4620
tgtctgcaat tttccaagga ccaatttctt tagacgctcc accaccacca gctatagcag 4680
atctgttaca atcagttaga acacctgagg taatcaagta ctgtcaagat aataaatgga 4740
tcattccagc agagtgccaa gtggaaagag acttaaatat agccagtagc ataatagcta 4800
ttatagcaaa tataataagt atagctggca ttatacttgt aatttataaa ttgttttgtt 4860
cattacaagg accatactca ggtgaaccta aacctaaaac caaagtacct gaaagaagag 4920
tagttgctca aggtccagaa gaagaatttg gaaggtcaat tctcaaaaac aatacttgtg 4980
tgattactac aggtaatgga aaatttacag gtcttggtat acatgacaga attctaatca 5040
tcccaacaca tgctgatcca ggtagagagg tccaagttaa tggtgtccac actaaggttc 5100
tagactcata tgatctttat aatagagatg gagttaaact tgaaataacg gtcatacaat 5160
tagatagaaa tgaaaaattt agggacatta gaaagtatat acctgaaaca gaagacgatt 5220
atccagaatg caatttggca ctttcagcta atcaagatga accaactata attaaagtag 5280
gagatgtagt gtcctatggc aatattttgc ttagtggaaa tcaaacagcc agaatgctta 5340
aatataatta ccccacaaaa tctgggtatt gtggaggggt actatataaa attggtcaaa 5400
ttctaggtat tcatgtgggt ggaaatggaa gggatggttt ttcagccatg ttacttagat 5460
catactttac agatactcag ggccaaatta aagtcaataa gcatgctact gaatgtggtc 5520
ttccaactat acacactcct agcaaaacca aacttcagcc tagtgtattt tatgatgtct 5580
tcccaggttc taaggaacca gctgtgctca cagataatga ccctagattg gaagttaatt 5640
ttaaagaagc tttattttct aaatataaag gtaatgtgga atgtaatttg aatgaacata 5700
tggaaattgc tattgcccat tactcagcac aattaatgac actagatatt gattccaggc 5760
caatagcatt ggaagatagc gtgtttggaa tagaaggact tgaggcttta gatctaaaca 5820
ccagtgcagg gtttccttat gtcacaatgg gtattaaaaa gagagattta ataaataaca 5880
aaacaaaaga tatatccagg cttaaagagg ctctagataa atatggagtt gacttaccca 5940
tgatcacttt cttaaaagac gagcttagga aaaaggagaa aatttcaaca ggtaaaacta 6000
gagttataga agcaagtagt ataaatgaca caatattatt tagaactact tttggcaatt 6060
tgttctctaa gtttcattta aacccaggcg ttgttactgg ctctgcagta gggtgtgacc 6120
ctgagacttt ctggtctaaa atcccagtta tgcttgatgg agattgtata atggcttttg 6180
actatacaaa ttatgatggt agtatacacc ctgtctggtt tcaagctctg aaaaaagttc 6240
ttgaaaattt atctttccaa tctaatttaa ttgatagatt gtgttattcc aagcacttgt 6300
ttaaatcaac atattatgaa gtggcaggtg gagttccttc tgggtgttct ggaaccagta 6360
tattcaatac tatgattaat aacattataa taagaacact agttctagat gcatacaaaa 6420
atattgatct ggacaagctt aaaataattg catatggtga tgatgtgatt ttctcttata 6480
aatatactct agatatggaa gctattgcta atgaaggaaa gaaatatgga cttacaataa 6540
caccagcaga taagtccaat gaattcaaga aacttgatta tagtaatgtg acttttctta 6600
aacgtggttt taagcaagat gaaagacata cattccttat tcatcctaca ttcccagtgg 6660
aagagataca tgaatcaatt agatggacca agaaaccttc acagatgcaa gaacatgtgc 6720
tatcattatg tcacctgatg tggcacaatg gacgtaaggt gtatgaagat ttctctagta 6780
agatacgcag tgtcagcgct ggacgtgcac tgtatatccc accttatgat ctgttgaaac 6840
atgaatggta tgaaaaattt tagatataga aataatgaat gaatgattct ttaattctat 6900
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 6931
<210> 58
<211> 7087
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 58
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
caagaatagt tacagaaaaa cagaaacatt ctgttgtcat cacaacacac atatatcata 3060
aagctaaaca cacaaaagct tggtgtccta ggccccctag agctgtccct tacacacata 3120
gtcatgtgac taattatatg ccagaaacag gtgacgtgac aacagccata gtccgcagaa 3180
acactataac aactgctggg cccagtgatc tatatgtgca tgtaggtaac ttaatatata 3240
gaaacttaca tctgttcaat tctgaaatgc atgattcaat tttgatttca tactcttctg 3300
atttaatcat ataccgcaca aacactatag gtgatgatta tattcccaat tgtaactgca 3360
ctgaggctac ttattattgt agacacaaaa ataggtatta cccaataaaa gttactccac 3420
atgattggta tgaaatacaa gagagtgaat attaccccaa acacatccaa tacaacctat 3480
taattggtga aggtcatgta gcatttatag atcttagaca atttcactgt gctgaggaac 3540
aaggcataac tgattacata cacatgttgg gagaggcttt tggcaatggt tttgtagata 3600
gtgttaaaga acaaataaat gcaataaatc caatcaataa cattagtaag aaggttatta 3660
agtggctact tagaataatc tcggctatgg ttattataat cagaaactcc tctgaccctc 3720
aaacgatcat agcaaccttg acactaattg gttgcaatgg ttcaccatgg agatttctca 3780
aagaaaagtt ttgcaaatgg acccaattaa cttatatcca caaagagtct gattcatggc 3840
ttaagaaatt cactgaaatg tgtaatgctg cacgtggtct tgaatggatt ggtaataaaa 3900
tttcaaaatt tatagattgg atgaaatcta tgctacccca ggcccaattg aaagttaaat 3960
acttgaatga aataaagaaa ctcagtttgc ttgaaaaaca gattgaaaat ctacgtgcgg 4020
cagatagtgc aacacaagag aaaatcaaat gtgaaattga caccctacat gatctatcgt 4080
gcaaatttct tcctttgtat gcacatgagg caaaaagaat caaagtgctt tataataaat 4140
gttccaatat aattaaacaa agaaagagaa gtgaaccggt ggcggtgatg atacatggac 4200
cacccggtac tggtaaatct ataacaacta acttcttggc tagaatgata acaaatgaaa 4260
gtgatgtgta ctcattacct ccagatccca aatattttga tggttatgac aatcagagtg 4320
ttgtaatcat ggatgatatt atgcaaaatc cagatggaga agacatgaca ctattttgcc 4380
aaatggtttc aagtgttaca tttataccac ccatggctga tttgcctgac aagggtaaac 4440
catttgattc aagatttatc ttatgtagta ctaaccactc gcttttagcc ccacctacta 4500
tatcttcatt acccgcaatg aatagaagat ttttctttga cttagatatt gtagttcatg 4560
acaattataa agatacacaa gggaaattag atgtatccaa agcttttcga ccttgtaatg 4620
ttaacaccaa aattggcaat gcaagatgtt gtccatttgt atgtggtaag gcagtgacat 4680
tcaaagatcg cagcacttgc tcaacataca ccttagctca agtttacaat cacattttgg 4740
aagaagacaa aagaaggaga caggtggtgg atgtcatgtc tgcaattttc caaggaccaa 4800
tttctttaga cgctccacca ccaccagcta tagcagatct gttacaatca gttagaacac 4860
ctgaggtaat caagtactgt caagataata aatggatcat tccagcagag tgccaagtgg 4920
aaagagactt aaatatagcc agtagcataa tagctattat agcaaatata ataagtatag 4980
ctggcattat acttgtaatt tataaattgt tttgttcatt acaaggacca tactcaggtg 5040
aacctaaacc taaaaccaaa gtacctgaaa gaagagtagt tgctcaaggt ccagaagaag 5100
aatttggaag gtcaattctc aaaaacaata cttgtgtgat tactacaggt aatggaaaat 5160
ttacaggtct tggtatacat gacagaattc taatcatccc aacacatgct gatccaggta 5220
gagaggtcca agttaatggt gtccacacta aggttctaga ctcatatgat ctttataata 5280
gagatggagt taaacttgaa ataacggtca tacaattaga tagaaatgaa aaatttaggg 5340
acattagaaa gtatatacct gaaacagaag acgattatcc agaatgcaat ttggcacttt 5400
cagctaatca agatgaacca actataatta aagtaggaga tgtagtgtcc tatggcaata 5460
ttttgcttag tggaaatcaa acagccagaa tgcttaaata taattacccc acaaaatctg 5520
ggtattgtgg aggggtacta tataaaattg gtcaaattct aggtattcat gtgggtggaa 5580
atggaaggga tggtttttca gccatgttac ttagatcata ctttacagat actcagggcc 5640
aaattaaagt caataagcat gctactgaat gtggtcttcc aactatacac actcctagca 5700
aaaccaaact tcagcctagt gtattttatg atgtcttccc aggttctaag gaaccagctg 5760
tgctcacaga taatgaccct agattggaag ttaattttaa agaagcttta ttttctaaat 5820
ataaaggtaa tgtggaatgt aatttgaatg aacatatgga aattgctatt gcccattact 5880
cagcacaatt aatgacacta gatattgatt ccaggccaat agcattggaa gatagcgtgt 5940
ttggaataga aggacttgag gctttagatc taaacaccag tgcagggttt ccttatgtca 6000
caatgggtat taaaaagaga gatttaataa ataacaaaac aaaagatata tccaggctta 6060
aagaggctct agataaatat ggagttgact tacccatgat cactttctta aaagacgagc 6120
ttaggaaaaa ggagaaaatt tcaacaggta aaactagagt tatagaagca agtagtataa 6180
atgacacaat attatttaga actacttttg gcaatttgtt ctctaagttt catttaaacc 6240
caggcgttgt tactggctct gcagtagggt gtgaccctga gactttctgg tctaaaatcc 6300
cagttatgct tgatggagat tgtataatgg cttttgacta tacaaattat gatggtagta 6360
tacaccctgt ctggtttcaa gctctgaaaa aagttcttga aaatttatct ttccaatcta 6420
atttaattga tagattgtgt tattccaagc acttgtttaa atcaacatat tatgaagtgg 6480
caggtggagt tccttctggg tgttctggaa ccagtatatt caatactatg attaataaca 6540
ttataataag aacactagtt ctagatgcat acaaaaatat tgatctggac aagcttaaaa 6600
taattgcata tggtgatgat gtgattttct cttataaata tactctagat atggaagcta 6660
ttgctaatga aggaaagaaa tatggactta caataacacc agcagataag tccaatgaat 6720
tcaagaaact tgattatagt aatgtgactt ttcttaaacg tggttttaag caagatgaaa 6780
gacatacatt ccttattcat cctacattcc cagtggaaga gatacatgaa tcaattagat 6840
ggaccaagaa accttcacag atgcaagaac atgtgctatc attatgtcac ctgatgtggc 6900
acaatggacg taaggtgtat gaagatttct ctagtaagat acgcagtgtc agcgctggac 6960
gtgcactgta tatcccacct tatgatctgt tgaaacatga atggtatgaa aaattttaga 7020
tatagaaata atgaatgaat gattctttaa ttctataaaa aaaaaaaaaa aaaaaaaaaa 7080
aaaaaaa 7087
<210> 59
<211> 7087
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 59
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
caagaatagt tacagaaaaa cagaaacatt ctgttgtcat cacaacacac atatatcata 3060
aagctaaaca cacaaaagct tggtgtccta ggccccctag agctgtccct tacacacata 3120
gtcatgtgac taattatatg ccagaaacag gtgacgtgac aacagccata gtccgcagaa 3180
acactataac aactgctggg cccagtgatc tatatgtgca tgtaggtaac ttaatatata 3240
gaaacttaca tctgttcaat tctgaaatgc atgattcaat tttgatttca tactcttctg 3300
atttaatcat ataccgcaca aacactatag gtgatgatta tattcccaat tgtaactgca 3360
ctgaggctac ttattattgt agacacaaaa ataggtatta cccaataaaa gttactccac 3420
atgattggta tgaaatacaa gagagtgaat attaccccaa acacatccaa tacaacctat 3480
taattggtga aggaccatgt gaacctggtg attgtggtgg aaaacttctt tgtagacatg 3540
gtgtcattgg cataatcaca gcaggtggtg aaggtcatgt agcatttata gatcttagac 3600
aatttcactg tgctgaggaa caaggcataa ctgattacat acacatgttg ggagaggctt 3660
ttggcaatgg ttttgtagat agtgttaaag aacaaataaa tgcaataaat ccaatcaata 3720
acattagtaa gaaggttatt aagtggctac ttagaataat ctcggctatg gttattataa 3780
tcagaaactc ctctgaccct caaacgatca tagcaacctt gacactaatt ggttgcaatg 3840
gttcaccatg gagatttctc aaagaaaagt tttgcaaatg gacccaatta acttatatcc 3900
acaaagagtc tgattcatgg cttaagaaat tcactgaaat gtgtaatgct gcacgtggtc 3960
ttgaatggat tggtaataaa atttcaaaat ttatagattg gatgaaatct atgctacccc 4020
aggcccaatt gaaagttaaa tacttgaatg aaataaagaa actcagtttg cttgaaaaac 4080
agattgaaaa tctacgtgcg gcagatagtg caacacaaga gaaaatcaaa tgtgaaattg 4140
acaccctaca tgatctatcg tgcaaatttc ttcctttgta tgcacatgag gcaaaaagaa 4200
tcaaagtgct ttataataaa tgttccaata taattaaaca aagaaagaga agtgaaccgg 4260
tggcggtgat gatacatgga ccacccggta ctggtaaatc tataacaact aacttcttgg 4320
ctagaatgat aacaaatgaa agtgatgtgt actcattacc tccagatccc aaatattttg 4380
atggttatga caatcagagt gttgtaatca tggatgatat tatgcaaaat ccagatggag 4440
aagacatgac actattttgc caaatggttt caagtgttac atttatacca cccatggctg 4500
atttgcctga caagggtaaa ccatttgatt caagatttat cttatgtagt actaaccact 4560
cgcttttagc cccacctact atatcttcat tacccgcaat gaatagaaga tttttctttg 4620
acttagatat tgtagttcat gacaattata aagatacaca agggaaatta gatgtatcca 4680
aagcttttcg accttgtaat gttaacacca aaattggcaa tgcaagatgt tgtccatttg 4740
tatgtggtaa ggcagtgaca ttcaaagatc gcagcacttg ctcaacatac accttagctc 4800
aagtttacaa tcacattttg gaagaagaca aaagaaggag acaggtggtg gatgtcatgt 4860
ctgcaatttt ccaaggacca atttctttag acgctccacc accaccagct atagcagatc 4920
tgttacaatc agttagaaca cctgaggtaa tcaagtactg tcaagataat aaatggatca 4980
ttccagcaga gtgccaagtg gataaattgt tttgttcatt acaaggacca tactcaggtg 5040
aacctaaacc taaaaccaaa gtacctgaaa gaagagtagt tgctcaaggt ccagaagaag 5100
aatttggaag gtcaattctc aaaaacaata cttgtgtgat tactacaggt aatggaaaat 5160
ttacaggtct tggtatacat gacagaattc taatcatccc aacacatgct gatccaggta 5220
gagaggtcca agttaatggt gtccacacta aggttctaga ctcatatgat ctttataata 5280
gagatggagt taaacttgaa ataacggtca tacaattaga tagaaatgaa aaatttaggg 5340
acattagaaa gtatatacct gaaacagaag acgattatcc agaatgcaat ttggcacttt 5400
cagctaatca agatgaacca actataatta aagtaggaga tgtagtgtcc tatggcaata 5460
ttttgcttag tggaaatcaa acagccagaa tgcttaaata taattacccc acaaaatctg 5520
ggtattgtgg aggggtacta tataaaattg gtcaaattct aggtattcat gtgggtggaa 5580
atggaaggga tggtttttca gccatgttac ttagatcata ctttacagat actcagggcc 5640
aaattaaagt caataagcat gctactgaat gtggtcttcc aactatacac actcctagca 5700
aaaccaaact tcagcctagt gtattttatg atgtcttccc aggttctaag gaaccagctg 5760
tgctcacaga taatgaccct agattggaag ttaattttaa agaagcttta ttttctaaat 5820
ataaaggtaa tgtggaatgt aatttgaatg aacatatgga aattgctatt gcccattact 5880
cagcacaatt aatgacacta gatattgatt ccaggccaat agcattggaa gatagcgtgt 5940
ttggaataga aggacttgag gctttagatc taaacaccag tgcagggttt ccttatgtca 6000
caatgggtat taaaaagaga gatttaataa ataacaaaac aaaagatata tccaggctta 6060
aagaggctct agataaatat ggagttgact tacccatgat cactttctta aaagacgagc 6120
ttaggaaaaa ggagaaaatt tcaacaggta aaactagagt tatagaagca agtagtataa 6180
atgacacaat attatttaga actacttttg gcaatttgtt ctctaagttt catttaaacc 6240
caggcgttgt tactggctct gcagtagggt gtgaccctga gactttctgg tctaaaatcc 6300
cagttatgct tgatggagat tgtataatgg cttttgacta tacaaattat gatggtagta 6360
tacaccctgt ctggtttcaa gctctgaaaa aagttcttga aaatttatct ttccaatcta 6420
atttaattga tagattgtgt tattccaagc acttgtttaa atcaacatat tatgaagtgg 6480
caggtggagt tccttctggg tgttctggaa ccagtatatt caatactatg attaataaca 6540
ttataataag aacactagtt ctagatgcat acaaaaatat tgatctggac aagcttaaaa 6600
taattgcata tggtgatgat gtgattttct cttataaata tactctagat atggaagcta 6660
ttgctaatga aggaaagaaa tatggactta caataacacc agcagataag tccaatgaat 6720
tcaagaaact tgattatagt aatgtgactt ttcttaaacg tggttttaag caagatgaaa 6780
gacatacatt ccttattcat cctacattcc cagtggaaga gatacatgaa tcaattagat 6840
ggaccaagaa accttcacag atgcaagaac atgtgctatc attatgtcac ctgatgtggc 6900
acaatggacg taaggtgtat gaagatttct ctagtaagat acgcagtgtc agcgctggac 6960
gtgcactgta tatcccacct tatgatctgt tgaaacatga atggtatgaa aaattttaga 7020
tatagaaata atgaatgaat gattctttaa ttctataaaa aaaaaaaaaa aaaaaaaaaa 7080
aaaaaaa 7087
<210> 60
<211> 7156
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 60
ttaaaactgg gtgtgggttg ttcccaccca caccacccaa tgggtgttgt actctgttat 60
tccggtaact ttgtacgcca gtttttccct cccctcccca tccttttacg taacttagaa 120
gttttaaata caagaccaat agtaggcaac tctccaggtt gtctaaggtc aagcacttct 180
gtttccccgg ttgatgttga tatgctccaa cagggcaaaa acaacagata ccgttatccg 240
caaagtgcct acacagagct tagtaggatt ctgaaagatc tttggttggt cgttcagctg 300
catacccagc agtagacctt gcagatgagg ctggacattc cccactggta acagtggtcc 360
agcctgcgtg gctgcctgcg cacctctcat gaggtgtgaa gccaaagatc ggacagggtg 420
tgaagagccg cgtgtgctca ctttgagtcc tccggcccct gaatgcggct aaccttaaac 480
ctgcagccat ggctcataag ccaatgagtt tatggtcgta atgagtaatt gcgggatggg 540
accgactact ttgggtgtcc gtgtttcact ttttccttta ttaattgctt atggtgacaa 600
tatatatatt gatatatatt ggcatcatgg gcgcccaggt atctagacaa aatgttggta 660
cacactcaac ccaaaattca gtgtcaaatg gatcaagttt aaattacttt aatataaatt 720
acttcaagga tgctgcctca agtggtgcat ctagattaga tttctctcaa gatccaagca 780
aattcactga cccagttaaa gatgtcttag aaaaggggat cccaacacta caatcaccat 840
ctgttgaggc ttgtggctat tcagacagga ttatgcaaat aaccagagga gattcaacaa 900
tcacatctca agatgtagca aatgctgtgg ttgggtatgg ggtctggccg cattacttaa 960
caccacaaga tgccactgct atagacaaac caacacaacc tgatacatca tcaaatagat 1020
tttatacact agagagtaaa cattggaatg gtagttcaaa aggatggtgg tggaaattac 1080
cagatgctct taaagacatg ggtatttttg gagaaaatat gtattatcat ttcctgggta 1140
gaagtggata tacagttcat gtgcagtgta atgctagtaa attccatcag ggtaccttgt 1200
tagttgtaat gataccagaa caccagctag caagtgcaaa acacggaagt gtgactgctg 1260
gttacgaact cacacaccca ggtgaggctg gcagagatgt aagtcaagaa cgtgatgcaa 1320
gtttaagaca acctagtgat gatagttggc ttaattttga tggcaccctt cttggaaatt 1380
tattaatttt cccacatcaa tttataaacc ttaggagtaa taattctgca actctaatag 1440
taccatatgt aaatgctgtg ccaatggatt caatgcttcg acataataac tggagcctgg 1500
tcatcatacc aattagtcca ttacgtagtg aaactacatc ttctaatata gtgccaatca 1560
ctgtatcaat aagtcccatg tgtgctgaat tttctggtgc aagagcaaaa aacattaaac 1620
aaggattacc tgtatatata actccaggat ctgggcaatt catgactact gatgatatgc 1680
aatcaccttg tgcactaccc tggtaccatc ctactaaaga aatatctatt ccgggtgaag 1740
ttaaaaacct tatagaaatg tgtcaagttg ataccttgat tccagtcaat aatgtgggta 1800
acaatgttgg aaatgtcagt atgtacactg tacaactagg gaaccaaaca ggcatggcac 1860
aaaaagtctt ttcaataaaa gtagacatta catcacagcc tttggctaca actttaattg 1920
gggagattgc aagctattac acccattgga ctggcagtct gcgatttagt tttatgtttt 1980
gtgggactgc aaacacaaca cttaaattat tacttgcata cacaccacct ggtattgatg 2040
aaccaacaac tagaaaggat gcaatgctag ggacacatgt tgtgtgggat gttggattgc 2100
agtctactat atctcttgtt gtaccatggg tgagtgccag ccacttcagg ttaactgcag 2160
ataataaata ctccatggct ggttatatca catgttggta ccaaactaat ttagtagtgc 2220
ccccaagtac gccacagact gctgatatgc tgtgttttgt ttctgcatgt aaagattttt 2280
gtctacgaat ggcaagggat acagatttac acatacaaag tggtccaata gagcaaaatc 2340
cagtagaaaa ctacattgat gaagttttaa atgaagtttt agtagtgccg aatataaaag 2400
aaagtcatca cactacatca aactctgccc cacttttaga tgctgcagag acgggacaca 2460
ccagtaatgt tcaaccagaa gatgctatag agacaaggta tgttataaca tcacaaacaa 2520
gagatgagat gagtatagaa agtttccttg gtagatctgg ttgtgtccac atctcaagaa 2580
taaaggttga ttacactgac tataatggac aggacataaa tttcacaaaa tggaaaatca 2640
cactacagga aatggcacag attaggagaa aatttgaatt gtttacatat gtcaggtttg 2700
actcagaaat aaccttggtg ccttgtattg ctggtagagg agacgacatt ggacatattg 2760
taatgcaata tatgtatgtt cctccaggag ctccaattcc ttcaaaaaga aacgatttct 2820
catggcaatc aggcaccaat atgtcaatat tctggcaaca tggacagcca tttcctagat 2880
tttctttacc atttcttagc attgcatcag cttattatat gttttatgat ggatatgatg 2940
gagacaacac ttcttccaag tatggtagcg tagttactaa tgatatgggt actatatgct 3000
caagaatagt tacagaaaaa cagaaacatt ctgttgtcat cacaacacac atatatcata 3060
aagctaaaca cacaaaagct tggtgtccta ggccccctag agctgtccct tacacacata 3120
gtcatgtgac taattatatg ccagaaacag gtgacgtgac aacagccata gtccgcagaa 3180
acactataac aactgctggg cccagtgatc tatatgtgca tgtaggtaac ttaatatata 3240
gaaacttaca tctgttcaat tctgaaatgc atgattcaat tttgatttca tactcttctg 3300
atttaatcat ataccgcaca aacactatag gtgatgatta tattcccaat tgtaactgca 3360
ctgaggctac ttattattgt agacacaaaa ataggtatta cccaataaaa gttactccac 3420
atgattggta tgaaatacaa gagagtgaat attaccccaa acacatccaa tacaacctat 3480
taattggtga aggaccatgt gaacctggtg attgtggtgg aaaacttctt tgtagacatg 3540
gtgtcattgg cataatcaca gcaggtggtg aaggtcatgt agcatttata gatcttagac 3600
aatttcactg tgctgaggaa caaggcataa ctgattacat acacatgttg ggagaggctt 3660
ttggcaatgg ttttgtagat agtgttaaag aacaaataaa tgcaataaat ccaatcaata 3720
acattagtaa gaaggttatt aagtggctac ttagaataat ctcggctatg gttattataa 3780
tcagaaactc ctctgaccct caaacgatca tagcaacctt gacactaatt ggttgcaatg 3840
gttcaccatg gagatttctc aaagaaaagt tttgcaaatg gacccaatta acttatatcc 3900
acaaagagtc tgattcatgg cttaagaaat tcactgaaat gtgtaatgct gcacgtggtc 3960
ttgaatggat tggtaataaa atttcaaaat ttatagattg gatgaaatct atgctacccc 4020
aggcccaatt gaaagttaaa tacttgaatg aaataaagaa actcagtttg cttgaaaaac 4080
agattgaaaa tctacgtgcg gcagatagtg caacacaaga gaaaatcaaa tgtgaaattg 4140
acaccctaca tgatctatcg tgcaaatttc ttcctttgta tgcacatgag gcaaaaagaa 4200
tcaaagtgct ttataataaa tgttccaata taattaaaca aagaaagaga agtgaaccgg 4260
tggcggtgat gatacatgga ccacccggta ctggtaaatc tataacaact aacttcttgg 4320
ctagaatgat aacaaatgaa agtgatgtgt actcattacc tccagatccc aaatattttg 4380
atggttatga caatcagagt gttgtaatca tggatgatat tatgcaaaat ccagatggag 4440
aagacatgac actattttgc caaatggttt caagtgttac atttatacca cccatggctg 4500
atttgcctga caagggtaaa ccatttgatt caagatttat cttatgtagt actaaccact 4560
cgcttttagc cccacctact atatcttcat tacccgcaat gaatagaaga tttttctttg 4620
acttagatat tgtagttcat gacaattata aagatacaca agggaaatta gatgtatcca 4680
aagcttttcg accttgtaat gttaacacca aaattggcaa tgcaagatgt tgtccatttg 4740
tatgtggtaa ggcagtgaca ttcaaagatc gcagcacttg ctcaacatac accttagctc 4800
aagtttacaa tcacattttg gaagaagaca aaagaaggag acaggtggtg gatgtcatgt 4860
ctgcaatttt ccaaggacca atttctttag acgctccacc accaccagct atagcagatc 4920
tgttacaatc agttagaaca cctgaggtaa tcaagtactg tcaagataat aaatggatca 4980
ttccagcaga gtgccaagtg gaaagagact taaatatagc cagtagcata atagctatta 5040
tagcaaatat aataagtata gctggcatta tacttgtaat ttataaattg ttttgttcat 5100
tacaaggacc atactcaggt gaacctaaac ctaaaaccaa agtacctgaa agaagagtag 5160
ttgctcaagg tccagaagaa gaatttggaa ggtcaattct caaaaacaat acttgtgtga 5220
ttactacagg taatggaaaa tttacaggtc ttggtataca tgacagaatt ctaatcatcc 5280
caacacatgc tgatccaggt agagaggtcc aagttaatgg tgtccacact aaggttctag 5340
actcatatga tctttataat agagatggag ttaaacttga aataacggtc atacaattag 5400
atagaaatga aaaatttagg gacattagaa agtatatacc tgaaacagaa gacgattatc 5460
cagaatgcaa tttggcactt tcagctaatc aagatgaacc aactataatt aaagtaggag 5520
atgtagtgtc ctatggcaat attttgctta gtggaaatca aacagccaga atgcttaaat 5580
ataattaccc cacaaaatct gggtattgtg gaggggtact atataaaatt ggtcaaattc 5640
taggtattca tgtgggtgga aatggaaggg atggtttttc agccatgtta cttagatcat 5700
actttacaga tactcagggc caaattaaag tcaataagca tgctactgaa tgtggtcttc 5760
caactataca cactcctagc aaaaccaaac ttcagcctag tgtattttat gatgtcttcc 5820
aaccagctgt gctcacagat aatgacccta gattggaagt taattttaaa gaagctttat 5880
tttctaaata taaaggtaat gtggaatgta atttgaatga acatatggaa attgctattg 5940
cccattactc agcacaatta atgacactag atattgattc caggccaata gcattggaag 6000
atagcgtgtt tggaatagaa ggacttgagg ctttagatct aaacaccagt gcagggtttc 6060
cttatgtcac aatgggtatt aaaaagagag atttaataaa taacaaaaca aaagatatat 6120
ccaggcttaa agaggctcta gataaatatg gagttgactt acccatgatc actttcttaa 6180
aagacgagct taggaaaaag gagaaaattt caacaggtaa aactagagtt atagaagcaa 6240
gtagtataaa tgacacaata ttatttagaa ctacttttgg caatttgttc tctaagtttc 6300
atttaaaccc aggcgttgtt actggctctg cagtagggtg tgaccctgag actttctggt 6360
ctaaaatccc agttatgctt gatggagatt gtataatggc ttttgactat acaaattatg 6420
atggtagtat acaccctgtc tggtttcaag ctctgaaaaa agttcttgaa aatttatctt 6480
tccaatctaa tttaattgat agattgtgtt attccaagca cttgtttaaa tcaacatatt 6540
atgaagtggc aggtggagtt ccttctgggt gttctggaac cagtatattc aatactatga 6600
ttaataacat tataataaga acactagttc tagatgcata caaaaatatt gatctggaca 6660
agcttaaaat aattgcatat ggtgatgatg tgattttctc ttataaatat actctagata 6720
tggaagctat tgctaatgaa ggaaagaaat atggacttac aataacacca gcagataagt 6780
ccaatgaatt caagaaactt gattatagta atgtgacttt tcttaaacgt ggttttaagc 6840
aagatgaaag acatacattc cttattcatc ctacattccc agtggaagag atacatgaat 6900
caattagatg gaccaagaaa ccttcacaga tgcaagaaca tgtgctatca ttatgtcacc 6960
tgatgtggca caatggacgt aaggtgtatg aagatttctc tagtaagata cgcagtgtca 7020
gcgctggacg tgcactgtat atcccacctt atgatctgtt gaaacatgaa tggtatgaaa 7080
aattttagat atagaaataa tgaatgaatg attctttaat tctataaaaa aaaaaaaaaa 7140
aaaaaaaaaa aaaaaa 7156
<210> 61
<211> 7169
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 61
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag atattgcctc acatccctta gccacaaccc tcattggtga gatagcaagt 1920
tactttacac actggacagg gagcctgcga ttcagtttca tgttttgcgg gactgcaaac 1980
actaccttaa aagttttgct agcatataca cccccaggga ttggtaagcc tagaagtaga 2040
aaggaagcaa tgttagggac acacgtggtg tgggatgtag gtttacaatc tacagtgtca 2100
ttggttgtac catggatcag tgccagtcag tatagattca ctacaccaga cacatactcc 2160
tcagcaggct acattacatg ctggtatcaa actaattttg ttgttccacc aaacacacct 2220
aacactgctg agatgttgtg ttttgtatct ggatgcaagg acttttgcct tcggatggca 2280
agagacacag acctgcacaa gcaaacagga ccaataacac aaaatccagt ggaaagatat 2340
gtagatgaag tcttaaatga agtgttagta gtgcccaata ttaatgagag ccaccctacc 2400
acatcaaatg cggccccagt tttggatgct gctgaaacag gacataccaa taagatacag 2460
ccagaagaca ctatagaaac cagatatgtg caatcttcac agacattgga tgaaatgagt 2520
gtggaaagct tcctaggcag atcggggtgc atccatgaat cagtgttgga tattgtggac 2580
aattacaatg atcaaagttt cactaaatgg aagataaacc tgcaagaaat ggcacaaatt 2640
agaagaaaat ttgaaatgtt tacttatgca agatttgact ctgaaattac tatggtacca 2700
agtgtagcag ccaaagatgg tcacattggt catatagtca tgcaatatat gtatgtacca 2760
ccaggagcac ctataccaac aactagaaat gactatgctt ggcaatctgg aacaaatgca 2820
tctgtatttt ggcagcatgg gcaacctttc cctcgctttt cacttccctt tttgagtatt 2880
gcatcagcat attacatgtt ttatgatggt tatgatggag acacatataa atccagatat 2940
ggaactgtag tcaccaatga catgggaact ttgtgttcgc gtattgtgac cagtgagcaa 3000
ttacacaaag tcaaagtggt aacaaggata tatcacaaag ccaaacacac caaagcttgg 3060
tgcccaagac cacccagagc tgttcaatac tcacatacac ataccaccaa ctacaaattg 3120
agttcagaag tacacaatga tgtggctata agacctagaa caaatctaac aactgttggg 3180
cctagtgaca tgtatgtgca tgttggtaat ctaatataca gaaatctaca tttatttaac 3240
tctgacatac atgattccat tttagtgtct tattcatcag atttaatcat ataccgaaca 3300
agcacacaag gtgatgatta tattccaaca tgtaattgca ctgaagctac atattactgc 3360
aaacacaaaa acaggtacta cccaattaat gtcacacctc atgactggta tgagatacaa 3420
gagagtgaat attatccaaa acatatccag tacaatttac taataggtga aggaccatgt 3480
gaaccaggtg attgtggtgg gaaattatta tgcaaacatg gagtgatagg tattattaca 3540
gcaggtggtg agggccatgt tgcattcata gatcttagac actttcactg tgctgaagaa 3600
caaggaatca ctgattacat acacatgctc ggcgaagctt ttggcagtgg atttgtagat 3660
agtgttaaag accagattaa ttcaataaat cccatcaata acattagcag taagatggtt 3720
aaatggatgt taagaattat atcagctatg gttataatta ttagaaactc ttcagatccg 3780
caaacaataa ttgccacttt aacactgatt ggatgcaatg gttctccttg gagatttctc 3840
aaagaaaagt tctgtaaatg gactcaatta acttatatac acaaagaatc agattcatgg 3900
ctcaaaaaat tcactgagat gtgtaatgca gctagggggc tagaatggat tggaaacaaa 3960
atatccaaat ttatcgattg gatgaaatca atgctacccc aggcacaatt aaaagttaag 4020
tatttgagtg aacttaagaa actcaacttt ctggagaaac aggttgaaaa tctcagagca 4080
gctgatacta acactcaaga aaaaatcaag tgtgagatag atacattgca tgacttatcc 4140
tgtaagtttt tacctctgta tgccagtgaa gcaaagagaa ttaaagtgtt gtatcacaag 4200
tgcactaaca taattaaaca gaagaagaga agtgaacctg tagcagttat gatacacggg 4260
cctcctggga ccggaaaatc aatcactaca agcttcctgg ctagaatgat tactaatgag 4320
agtgacatat actcacttcc accagaccct aaatattttg atggttatga taaccagagt 4380
gtagtaataa tggatgacat catgcaaaac cctggtggtg aggacatgac attattctgt 4440
cagatggtat ctagtgtgac ttttataccc ccaatggctg atctaccaga taagggaaaa 4500
ccctttgatt ctagatttgt attgtgtagt actaatcact cactcttggc acccccaact 4560
atatcgtcgc tcccagcaat gaatagaaga ttctatttag atttagatat tcttgtgcat 4620
gataactaca aagataatca gggtaagtta gatgtttcta gagcatttcg actatgtgat 4680
gttgattcaa agattggaaa tgcaaaatgt tgtccatttg tatgtggcaa ggcagtgaca 4740
ttcaaggacc gcaacacatg tagaacttat tcactttccc aaatatacaa ccaaattctt 4800
gaggaagaca agagaaggag acaggtggtt gatgtcatgt ctgcaatttt ccaagggcct 4860
atatccatgg gtaaaccccc accaccagct ataacagacc ttttacactc agtaaggaca 4920
ccagaagtaa ttaagtactg ccaagacaat aaatggatag ttcctgcgga ctgccaaatt 4980
gaaagggatc tgaatatagc taatagcata atcacaatca tagctaatat catcagtata 5040
gcagggatta tatatataat ttataagctc ttttgctctc tacagggccc ttactcgggg 5100
gagcccaaac ctaagacaaa agttcccgag agaagagtgg tagctcaagg tccagaagaa 5160
gaatttggaa tgtctattat taaaaataat acctgtgttg tgaccacaac aaatggaaaa 5220
tttacaggat taggcattta tgacagaatc ttaatattac caacacatgc tgacccgggc 5280
agtgaaattc aagtaaatgg aatacacacc aaagtgcttg attcttatga cttgtttaat 5340
aaggaaggtg tcaagttgga aattactgtg ctaaagttag atagaaatga gaagttcagg 5400
gatatacgta agtacatacc tgaatcagaa gatgactatc ctgaatgcaa cctagcacta 5460
gtggccaatc aaacagaacc aactataatc aaagtagggg atgttgtgtc ttatggtaat 5520
atattactta gtggcacaca gacagccaga atgcttaaat ataactatcc tacaaaatct 5580
gggtattgtg gtggtgtgtt atacaagatt ggccagatct taggtataca tgtgggtggc 5640
aatggtagag atgggttttc atctatgcta ttgagatcat acttcactga acaacaaggc 5700
caaattcaaa tctctaaaca tgttaaagat gttggcttac cctcaataca tacgccaact 5760
aaaactaaat tgcagccaag tgtcttctat gacatttttc caggcagtaa ggaaccagca 5820
gtcctcacag aaaaagatcc tagattgaaa gtggactttg actcagctct tttttcaaaa 5880
tacaaaggta acacagagtg cagtttgaat gaacatatac aagttgcagt agcacactac 5940
tcagctcagc tagcaacact agatatagat ccacaaccaa ttgcaatgga agatagtgtt 6000
tttggaatgg atggcttgga agctttggat ctgaatacta gtgcaggtta tccctatgta 6060
acactaggaa ttaaaaagaa agatcttatt aataacaaga ctaaagatat ttccaaactt 6120
aagctagcat tagacaaata tggtgttgat ttgcccatga ttactttctt aaaagatgaa 6180
cttagaaaga aggataagat agcagcaggc aaaaccagag ttatagaagc tagtagtata 6240
aatgatacca ttttgtttag aacagtttat ggaaacctat tttctaaatt tcacttgaac 6300
ccaggagtgg taacaggctg tgcagttgga tgtgatccag aaaccttttg gtctaaaatt 6360
cccttgatgt tagatggaga ttgcattatg gcttttgatt atacaaatta tgatggtagc 6420
attcatccaa tttggtttaa agctctcgga atggtacttg ataatttatc ctttaaccct 6480
actctaatca atagactttg taaatcaaaa catattttca agtccacata ttatgaagtt 6540
gaaggtggtg tgccctctgg ttgttctgga actagtatat ttaactcaat gattaataat 6600
ataatcatta gaaccttagt tttggatgca tataaacata ttgatttaga taaacttaaa 6660
ataattgcct atggtgatga tgtgatcttt tcttacaagt ataaactaga catggaagcc 6720
atagccaagg aagggcagaa atatggactt actataacac ctgcagataa atctagtgaa 6780
ttcaaagaac ttgattatgg aaatgtaact tttcttaaaa gaggatttag acaagatgat 6840
aaatacaaat ttttgataca tcctactttt ccagttgaag agatttatga gtccattaga 6900
tggacaaaga aaccatctca aatgcaggag catgtcttat ccttgtgtca cttaatgtgg 6960
cacaatggtc ctgagattta taaggacttt gaaacaaaga tacgcagtgt cagcgctgga 7020
cgtgcactgt atatccctcc ttatgaactc ctaagacatg aatggtatga aaaattctag 7080
atatagaatt aataaatgaa tagtttgtta gttttataaa aaaaaaaaaa aaaaaaaaaa 7140
aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 7169
<210> 62
<211> 6959
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 62
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag gtttacaatc tacagtgtca ttggttgtac catggatcag tgccagtcag 1920
tatagattca ctacaccaga cacatactcc tcagcaggct acattacatg ctggtatcaa 1980
actaattttg ttgttccacc aaacacacct aacactgctg agatgttgtg ttttgtatct 2040
ggatgcaagg acttttgcct tcggatggca agagacacag acctgcacaa gcaaacagga 2100
ccaataacac aaaatccagt ggaaagatat gtagatgaag tcttaaatga agtgttagta 2160
gtgcccaata ttaatgagag ccaccctacc acatcaaatg cggccccagt tttggatgct 2220
gctgaaacag gacataccaa taagatacag ccagaagaca ctatagaaac cagatatgtg 2280
caatcttcac agacattgga tgaaatgagt gtggaaagct tcctaggcag atcggggtgc 2340
atccatgaat cagtgttgga tattgtggac aattacaatg atcaaagttt cactaaatgg 2400
aagataaacc tgcaagaaat ggcacaaatt agaagaaaat ttgaaatgtt tacttatgca 2460
agatttgact ctgaaattac tatggtacca agtgtagcag ccaaagatgg tcacattggt 2520
catatagtca tgcaatatat gtatgtacca ccaggagcac ctataccaac aactagaaat 2580
gactatgctt ggcaatctgg aacaaatgca tctgtatttt ggcagcatgg gcaacctttc 2640
cctcgctttt cacttccctt tttgagtatt gcatcagcat attacatgtt ttatgatggt 2700
tatgatggag acacatataa atccagatat ggaactgtag tcaccaatga catgggaact 2760
ttgtgttcgc gtattgtgac cagtgagcaa ttacacaaag tcaaagtggt aacaaggata 2820
tatcacaaag ccaaacacac caaagcttgg tgcccaagac cacccagagc tgttcaatac 2880
tcacatacac ataccaccaa ctacaaattg agttcagaag tacacaatga tgtggctata 2940
agacctagaa caaatctaac aactgttggg cctagtgaca tgtatgtgca tgttggtaat 3000
ctaatataca gaaatctaca tttatttaac tctgacatac atgattccat tttagtgtct 3060
tattcatcag atttaatcat ataccgaaca agcacacaag gtgatgatta tattccaaca 3120
tgtaattgca ctgaagctac atattactgc aaacacaaaa acaggtacta cccaattaat 3180
gtcacacctc atgactggta tgagatacaa gagagtgaat attatccaaa acatatccag 3240
tacaatttac taataggtga aggaccatgt gaaccaggtg attgtggtgg gaaattatta 3300
tgcaaacatg gagtgatagg tattattaca gcaggtggtg agggccatgt tgcattcata 3360
gatcttagac actttcactg tgctgaagaa caaggaatca ctgattacat acacatgctc 3420
ggcgaagctt ttggcagtgg atttgtagat agtgttaaag accagattaa ttcaataaat 3480
cccatcaata acattagcag taagatggtt aaatggatgt taagaattat atcagctatg 3540
gttataatta ttagaaactc ttcagatccg caaacaataa ttgccacttt aacactgatt 3600
ggatgcaatg gttctccttg gagatttctc aaagaaaagt tctgtaaatg gactcaatta 3660
acttatatac acaaagaatc agattcatgg ctcaaaaaat tcactgagat gtgtaatgca 3720
gctagggggc tagaatggat tggaaacaaa atatccaaat ttatcgattg gatgaaatca 3780
atgctacccc aggcacaatt aaaagttaag tatttgagtg aacttaagaa actcaacttt 3840
ctggagaaac aggttgaaaa tctcagagca gctgatacta acactcaaga aaaaatcaag 3900
tgtgagatag atacattgca tgacttatcc tgtaagtttt tacctctgta tgccagtgaa 3960
gcaaagagaa ttaaagtgtt gtatcacaag tgcactaaca taattaaaca gaagaagaga 4020
agtgaacctg tagcagttat gatacacggg cctcctggga ccggaaaatc aatcactaca 4080
agcttcctgg ctagaatgat tactaatgag agtgacatat actcacttcc accagaccct 4140
aaatattttg atggttatga taaccagagt gtagtaataa tggatgacat catgcaaaac 4200
cctggtggtg aggacatgac attattctgt cagatggtat ctagtgtgac ttttataccc 4260
ccaatggctg atctaccaga taagggaaaa ccctttgatt ctagatttgt attgtgtagt 4320
actaatcact cactcttggc acccccaact atatcgtcgc tcccagcaat gaatagaaga 4380
ttctatttag atttagatat tcttgtgcat gataactaca aagataatca gggtaagtta 4440
gatgtttcta gagcatttcg actatgtgat gttgattcaa agattggaaa tgcaaaatgt 4500
tgtccatttg tatgtggcaa ggcagtgaca ttcaaggacc gcaacacatg tagaacttat 4560
tcactttccc aaatatacaa ccaaattctt gaggaagaca agagaaggag acaggtggtt 4620
gatgtcatgt ctgcaatttt ccaagggcct atatccatgg gtaaaccccc accaccagct 4680
ataacagacc ttttacactc agtaaggaca ccagaagtaa ttaagtactg ccaagacaat 4740
aaatggatag ttcctgcgga ctgccaaatt gaaagggatc tgaatatagc taatagcata 4800
atcacaatca tagctaatat catcagtata gcagggatta tatatataat ttataagctc 4860
ttttgctctc tacagggccc ttactcgggg gagcccaaac ctaagacaaa agttcccgag 4920
agaagagtgg tagctcaagg tccagaagaa gaatttggaa tgtctattat taaaaataat 4980
acctgtgttg tgaccacaac aaatggaaaa tttacaggat taggcattta tgacagaatc 5040
ttaatattac caacacatgc tgacccgggc agtgaaattc aagtaaatgg aatacacacc 5100
aaagtgcttg attcttatga cttgtttaat aaggaaggtg tcaagttgga aattactgtg 5160
ctaaagttag atagaaatga gaagttcagg gatatacgta agtacatacc tgaatcagaa 5220
gatgactatc ctgaatgcaa cctagcacta gtggccaatc aaacagaacc aactataatc 5280
aaagtagggg atgttgtgtc ttatggtaat atattactta gtggcacaca gacagccaga 5340
atgcttaaat ataactatcc tacaaaatct gggtattgtg gtggtgtgtt atacaagatt 5400
ggccagatct taggtataca tgtgggtggc aatggtagag atgggttttc atctatgcta 5460
ttgagatcat acttcactga acaacaaggc caaattcaaa tctctaaaca tgttaaagat 5520
gttggcttac cctcaataca tacgccaact aaaactaaat tgcagccaag tgtcttctat 5580
gacatttttc caggcagtaa ggaaccagca gtcctcacag aaaaagatcc tagattgaaa 5640
gtggactttg actcagctct tttttcaaaa tacaaaggta acacagagtg cagtttgaat 5700
gaacatatac aagttgcagt agcacactac tcagctcagc tagcaacact agatatagat 5760
ccacaaccaa ttgcaatgga agatagtgtt tttggaatgg atggcttgga agctttggat 5820
ctgaatacta gtgcaggtta tccctatgta acactaggaa ttaaaaagaa agatcttatt 5880
aataacaaga ctaaagatat ttccaaactt aagctagcat tagacaaata tggtgttgat 5940
ttgcccatga ttactttctt aaaagatgaa cttagaaaga aggataagat agcagcaggc 6000
aaaaccagag ttatagaagc tagtagtata aatgatacca ttttgtttag aacagtttat 6060
ggaaacctat tttctaaatt tcacttgaac ccaggagtgg taacaggctg tgcagttgga 6120
tgtgatccag aaaccttttg gtctaaaatt cccttgatgt tagatggaga ttgcattatg 6180
gcttttgatt atacaaatta tgatggtagc attcatccaa tttggtttaa agctctcgga 6240
atggtacttg ataatttatc ctttaaccct actctaatca atagactttg taaatcaaaa 6300
catattttca agtccacata ttatgaagtt gaaggtggtg tgccctctgg ttgttctgga 6360
actagtatat ttaactcaat gattaataat ataatcatta gaaccttagt tttggatgca 6420
tataaacata ttgatttaga taaacttaaa ataattgcct atggtgatga tgtgatcttt 6480
tcttacaagt ataaactaga catggaagcc atagccaagg aagggcagaa atatggactt 6540
actataacac ctgcagataa atctagtgaa ttcaaagaac ttgattatgg aaatgtaact 6600
tttcttaaaa gaggatttag acaagatgat aaatacaaat ttttgataca tcctactttt 6660
ccagttgaag agatttatga gtccattaga tggacaaaga aaccatctca aatgcaggag 6720
catgtcttat ccttgtgtca cttaatgtgg cacaatggtc ctgagattta taaggacttt 6780
gaaacaaaga tacgcagtgt cagcgctgga cgtgcactgt atatccctcc ttatgaactc 6840
ctaagacatg aatggtatga aaaattctag atatagaatt aataaatgaa tagtttgtta 6900
gttttataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 6959
<210> 63
<211> 6958
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 63
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaatagg tttacaatct acagtgtcat tggttgtacc atggatcagt gccagtcagt 1920
atagattcac tacaccagac acatactcct cagcaggcta cattacatgc tggtatcaaa 1980
ctaattttgt tgttccacca aacacaccta acactgctga gatgttgtgt tttgtatctg 2040
gatgcaagga cttttgcctt cggatggcaa gagacacaga cctgcacaag caaacaggac 2100
caataacaca aaatccagtg gaaagatatg tagatgaagt cttaaatgaa gtgttagtag 2160
tgcccaatat taatgagagc caccctacca catcaaatgc ggccccagtt ttggatgctg 2220
ctgaaacagg acataccaat aagatacagc cagaagacac tatagaaacc agatatgtgc 2280
aatcttcaca gacattggat gaaatgagtg tggaaagctt cctaggcaga tcggggtgca 2340
tccatgaatc agtgttggat attgtggaca attacaatga tcaaagtttc actaaatgga 2400
agataaacct gcaagaaatg gcacaaatta gaagaaaatt tgaaatgttt acttatgcaa 2460
gatttgactc tgaaattact atggtaccaa gtgtagcagc caaagatggt cacattggtc 2520
atatagtcat gcaatatatg tatgtaccac caggagcacc tataccaaca actagaaatg 2580
actatgcttg gcaatctgga acaaatgcat ctgtattttg gcagcatggg caacctttcc 2640
ctcgcttttc acttcccttt ttgagtattg catcagcata ttacatgttt tatgatggtt 2700
atgatggaga cacatataaa tccagatatg gaactgtagt caccaatgac atgggaactt 2760
tgtgttcgcg tattgtgacc agtgagcaat tacacaaagt caaagtggta acaaggatat 2820
atcacaaagc caaacacacc aaagcttggt gcccaagacc acccagagct gttcaatact 2880
cacatacaca taccaccaac tacaaattga gttcagaagt acacaatgat gtggctataa 2940
gacctagaac aaatctaaca actgttgggc ctagtgacat gtatgtgcat gttggtaatc 3000
taatatacag aaatctacat ttatttaact ctgacataca tgattccatt ttagtgtctt 3060
attcatcaga tttaatcata taccgaacaa gcacacaagg tgatgattat attccaacat 3120
gtaattgcac tgaagctaca tattactgca aacacaaaaa caggtactac ccaattaatg 3180
tcacacctca tgactggtat gagatacaag agagtgaata ttatccaaaa catatccagt 3240
acaatttact aataggtgaa ggaccatgtg aaccaggtga ttgtggtggg aaattattat 3300
gcaaacatgg agtgataggt attattacag caggtggtga gggccatgtt gcattcatag 3360
atcttagaca ctttcactgt gctgaagaac aaggaatcac tgattacata cacatgctcg 3420
gcgaagcttt tggcagtgga tttgtagata gtgttaaaga ccagattaat tcaataaatc 3480
ccatcaataa cattagcagt aagatggtta aatggatgtt aagaattata tcagctatgg 3540
ttataattat tagaaactct tcagatccgc aaacaataat tgccacttta acactgattg 3600
gatgcaatgg ttctccttgg agatttctca aagaaaagtt ctgtaaatgg actcaattaa 3660
cttatataca caaagaatca gattcatggc tcaaaaaatt cactgagatg tgtaatgcag 3720
ctagggggct agaatggatt ggaaacaaaa tatccaaatt tatcgattgg atgaaatcaa 3780
tgctacccca ggcacaatta aaagttaagt atttgagtga acttaagaaa ctcaactttc 3840
tggagaaaca ggttgaaaat ctcagagcag ctgatactaa cactcaagaa aaaatcaagt 3900
gtgagataga tacattgcat gacttatcct gtaagttttt acctctgtat gccagtgaag 3960
caaagagaat taaagtgttg tatcacaagt gcactaacat aattaaacag aagaagagaa 4020
gtgaacctgt agcagttatg atacacgggc ctcctgggac cggaaaatca atcactacaa 4080
gcttcctggc tagaatgatt actaatgaga gtgacatata ctcacttcca ccagacccta 4140
aatattttga tggttatgat aaccagagtg tagtaataat ggatgacatc atgcaaaacc 4200
ctggtggtga ggacatgaca ttattctgtc agatggtatc tagtgtgact tttatacccc 4260
caatggctga tctaccagat aagggaaaac cctttgattc tagatttgta ttgtgtagta 4320
ctaatcactc actcttggca cccccaacta tatcgtcgct cccagcaatg aatagaagat 4380
tctatttaga tttagatatt cttgtgcatg ataactacaa agataatcag ggtaagttag 4440
atgtttctag agcatttcga ctatgtgatg ttgattcaaa gattggaaat gcaaaatgtt 4500
gtccatttgt atgtggcaag gcagtgacat tcaaggaccg caacacatgt agaacttatt 4560
cactttccca aatatacaac caaattcttg aggaagacaa gagaaggaga caggtggttg 4620
atgtcatgtc tgcaattttc caagggccta tatccatggg taaaccccca ccaccagcta 4680
taacagacct tttacactca gtaaggacac cagaagtaat taagtactgc caagacaata 4740
aatggatagt tcctgcggac tgccaaattg aaagggatct gaatatagct aatagcataa 4800
tcacaatcat agctaatatc atcagtatag cagggattat atatataatt tataagctct 4860
tttgctctct acagggccct tactcggggg agcccaaacc taagacaaaa gttcccgaga 4920
gaagagtggt agctcaaggt ccagaagaag aatttggaat gtctattatt aaaaataata 4980
cctgtgttgt gaccacaaca aatggaaaat ttacaggatt aggcatttat gacagaatct 5040
taatattacc aacacatgct gacccgggca gtgaaattca agtaaatgga atacacacca 5100
aagtgcttga ttcttatgac ttgtttaata aggaaggtgt caagttggaa attactgtgc 5160
taaagttaga tagaaatgag aagttcaggg atatacgtaa gtacatacct gaatcagaag 5220
atgactatcc tgaatgcaac ctagcactag tggccaatca aacagaacca actataatca 5280
aagtagggga tgttgtgtct tatggtaata tattacttag tggcacacag acagccagaa 5340
tgcttaaata taactatcct acaaaatctg ggtattgtgg tggtgtgtta tacaagattg 5400
gccagatctt aggtatacat gtgggtggca atggtagaga tgggttttca tctatgctat 5460
tgagatcata cttcactgaa caacaaggcc aaattcaaat ctctaaacat gttaaagatg 5520
ttggcttacc ctcaatacat acgccaacta aaactaaatt gcagccaagt gtcttctatg 5580
acatttttcc aggcagtaag gaaccagcag tcctcacaga aaaagatcct agattgaaag 5640
tggactttga ctcagctctt ttttcaaaat acaaaggtaa cacagagtgc agtttgaatg 5700
aacatataca agttgcagta gcacactact cagctcagct agcaacacta gatatagatc 5760
cacaaccaat tgcaatggaa gatagtgttt ttggaatgga tggcttggaa gctttggatc 5820
tgaatactag tgcaggttat ccctatgtaa cactaggaat taaaaagaaa gatcttatta 5880
ataacaagac taaagatatt tccaaactta agctagcatt agacaaatat ggtgttgatt 5940
tgcccatgat tactttctta aaagatgaac ttagaaagaa ggataagata gcagcaggca 6000
aaaccagagt tatagaagct agtagtataa atgataccat tttgtttaga acagtttatg 6060
gaaacctatt ttctaaattt cacttgaacc caggagtggt aacaggctgt gcagttggat 6120
gtgatccaga aaccttttgg tctaaaattc ccttgatgtt agatggagat tgcattatgg 6180
cttttgatta tacaaattat gatggtagca ttcatccaat ttggtttaaa gctctcggaa 6240
tggtacttga taatttatcc tttaacccta ctctaatcaa tagactttgt aaatcaaaac 6300
atattttcaa gtccacatat tatgaagttg aaggtggtgt gccctctggt tgttctggaa 6360
ctagtatatt taactcaatg attaataata taatcattag aaccttagtt ttggatgcat 6420
ataaacatat tgatttagat aaacttaaaa taattgccta tggtgatgat gtgatctttt 6480
cttacaagta taaactagac atggaagcca tagccaagga agggcagaaa tatggactta 6540
ctataacacc tgcagataaa tctagtgaat tcaaagaact tgattatgga aatgtaactt 6600
ttcttaaaag aggatttaga caagatgata aatacaaatt tttgatacat cctacttttc 6660
cagttgaaga gatttatgag tccattagat ggacaaagaa accatctcaa atgcaggagc 6720
atgtcttatc cttgtgtcac ttaatgtggc acaatggtcc tgagatttat aaggactttg 6780
aaacaaagat acgcagtgtc agcgctggac gtgcactgta tatccctcct tatgaactcc 6840
taagacatga atggtatgaa aaattctaga tatagaatta ataaatgaat agtttgttag 6900
ttttataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 6958
<210> 64
<211> 7124
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 64
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag atattgcctc acatccctta gccacaaccc tcattggtga gatagcaagt 1920
tactttacac actggacagg gagcctgcga ttcagtttca tgttttgcgg gactgcaaac 1980
actaccttaa aagttttgct agcatataca cccccaggga ttggtaagcc tagaagtaga 2040
aaggaagcaa tgttagggac acacgtggtg tgggatgtag gtttacaatc tacagtgtca 2100
ttggttgtac catggatcag tgccagtcag tatagattca ctacaccaga cacatactcc 2160
tcagcaggct acattacatg ctggtatcaa actaattttg ttgttccacc aaacacacct 2220
aacactgctg agatgttgtg ttttgtatct ggatgcaagg acttttgcct tcggatggca 2280
agagacacag acctgcacaa gcaaacagga ccaataacac aaaatccagt ggaaagatat 2340
gtagatgaag tcttaaatga agtgttagta gtgcccaata ttaatgagag ccaccctacc 2400
acatcaaatg cggccccagt tttggatgct gctgaaacag gacataccaa taagatacag 2460
ccagaagaca ctatagaaac cagatatgtg caatcttcac agacattgga tgaaatgagt 2520
gtggaaagct tcctaggcag atcggggtgc atccatgaat cagtgttgga tattgtggac 2580
aattacaatg atcaaagttt cactaaatgg aagataaacc tgcaagaaat ggcacaaatt 2640
agaagaaaat ttgaaatgtt tacttatgca agatttgact ctgaaattac tatggtacca 2700
agtgtagcag ccaaagatgg tcacattggt catatagtca tgcaatatat gtatgtacca 2760
ccaggagcac ctataccaac aactagaaat gactatgctt ggcaatctgg aacaaatgca 2820
tctgtatttt ggcagcatgg gcaacctttc cctcgctttt cacttccctt tttgagtatt 2880
gcatcagcat attacatgtt ttatgatggt tatgatggag acacatataa atccagatat 2940
ggaactgtag tcaccaatga catgggaact ttgtgttcgc gtattgtgac cagtgagcaa 3000
ttacacaaag tcaaagtggt aacaaggata tatcacaaag ccaaacacac caaagcttgg 3060
tgcccaagac cacccagagc tgttcaatac tcacatacac ataccaccaa ctacaaattg 3120
agttcagaag tacacaatga tgtggctata agacctagaa caaatctaat atacagaaat 3180
ctacatttat ttaactctga catacatgat tccattttag tgtcttattc atcagattta 3240
atcatatacc gaacaagcac acaaggtgat gattatattc caacatgtaa ttgcactgaa 3300
gctacatatt actgcaaaca caaaaacagg tactacccaa ttaatgtcac acctcatgac 3360
tggtatgaga tacaagagag tgaatattat ccaaaacata tccagtacaa tttactaata 3420
ggtgaaggac catgtgaacc aggtgattgt ggtgggaaat tattatgcaa acatggagtg 3480
ataggtatta ttacagcagg tggtgagggc catgttgcat tcatagatct tagacacttt 3540
cactgtgctg aagaacaagg aatcactgat tacatacaca tgctcggcga agcttttggc 3600
agtggatttg tagatagtgt taaagaccag attaattcaa taaatcccat caataacatt 3660
agcagtaaga tggttaaatg gatgttaaga attatatcag ctatggttat aattattaga 3720
aactcttcag atccgcaaac aataattgcc actttaacac tgattggatg caatggttct 3780
ccttggagat ttctcaaaga aaagttctgt aaatggactc aattaactta tatacacaaa 3840
gaatcagatt catggctcaa aaaattcact gagatgtgta atgcagctag ggggctagaa 3900
tggattggaa acaaaatatc caaatttatc gattggatga aatcaatgct accccaggca 3960
caattaaaag ttaagtattt gagtgaactt aagaaactca actttctgga gaaacaggtt 4020
gaaaatctca gagcagctga tactaacact caagaaaaaa tcaagtgtga gatagataca 4080
ttgcatgact tatcctgtaa gtttttacct ctgtatgcca gtgaagcaaa gagaattaaa 4140
gtgttgtatc acaagtgcac taacataatt aaacagaaga agagaagtga acctgtagca 4200
gttatgatac acgggcctcc tgggaccgga aaatcaatca ctacaagctt cctggctaga 4260
atgattacta atgagagtga catatactca cttccaccag accctaaata ttttgatggt 4320
tatgataacc agagtgtagt aataatggat gacatcatgc aaaaccctgg tggtgaggac 4380
atgacattat tctgtcagat ggtatctagt gtgactttta tacccccaat ggctgatcta 4440
ccagataagg gaaaaccctt tgattctaga tttgtattgt gtagtactaa tcactcactc 4500
ttggcacccc caactatatc gtcgctccca gcaatgaata gaagattcta tttagattta 4560
gatattcttg tgcatgataa ctacaaagat aatcagggta agttagatgt ttctagagca 4620
tttcgactat gtgatgttga ttcaaagatt ggaaatgcaa aatgttgtcc atttgtatgt 4680
ggcaaggcag tgacattcaa ggaccgcaac acatgtagaa cttattcact ttcccaaata 4740
tacaaccaaa ttcttgagga agacaagaga aggagacagg tggttgatgt catgtctgca 4800
attttccaag ggcctatatc catgggtaaa cccccaccac cagctataac agacctttta 4860
cactcagtaa ggacaccaga agtaattaag tactgccaag acaataaatg gatagttcct 4920
gcggactgcc aaattgaaag ggatctgaat atagctaata gcataatcac aatcatagct 4980
aatatcatca gtatagcagg gattatatat ataatttata agctcttttg ctctctacag 5040
ggcccttact cgggggagcc caaacctaag acaaaagttc ccgagagaag agtggtagct 5100
caaggtccag aagaagaatt tggaatgtct attattaaaa ataatacctg tgttgtgacc 5160
acaacaaatg gaaaatttac aggattaggc atttatgaca gaatcttaat attaccaaca 5220
catgctgacc cgggcagtga aattcaagta aatggaatac acaccaaagt gcttgattct 5280
tatgacttgt ttaataagga aggtgtcaag ttggaaatta ctgtgctaaa gttagataga 5340
aatgagaagt tcagggatat acgtaagtac atacctgaat cagaagatga ctatcctgaa 5400
tgcaacctag cactagtggc caatcaaaca gaaccaacta taatcaaagt aggggatgtt 5460
gtgtcttatg gtaatatatt acttagtggc acacagacag ccagaatgct taaatataac 5520
tatcctacaa aatctgggta ttgtggtggt gtgttataca agattggcca gatcttaggt 5580
atacatgtgg gtggcaatgg tagagatggg ttttcatcta tgctattgag atcatacttc 5640
actgaacaac aaggccaaat tcaaatctct aaacatgtta aagatgttgg cttaccctca 5700
atacatacgc caactaaaac taaattgcag ccaagtgtct tctatgacat ttttccaggc 5760
agtaaggaac cagcagtcct cacagaaaaa gatcctagat tgaaagtgga ctttgactca 5820
gctctttttt caaaatacaa aggtaacaca gagtgcagtt tgaatgaaca tatacaagtt 5880
gcagtagcac actactcagc tcagctagca acactagata tagatccaca accaattgca 5940
atggaagata gtgtttttgg aatggatggc ttggaagctt tggatctgaa tactagtgca 6000
ggttatccct atgtaacact aggaattaaa aagaaagatc ttattaataa caagactaaa 6060
gatatttcca aacttaagct agcattagac aaatatggtg ttgatttgcc catgattact 6120
ttcttaaaag atgaacttag aaagaaggat aagatagcag caggcaaaac cagagttata 6180
gaagctagta gtataaatga taccattttg tttagaacag tttatggaaa cctattttct 6240
aaatttcact tgaacccagg agtggtaaca ggctgtgcag ttggatgtga tccagaaacc 6300
ttttggtcta aaattccctt gatgttagat ggagattgca ttatggcttt tgattataca 6360
aattatgatg gtagcattca tccaatttgg tttaaagctc tcggaatggt acttgataat 6420
ttatccttta accctactct aatcaataga ctttgtaaat caaaacatat tttcaagtcc 6480
acatattatg aagttgaagg tggtgtgccc tctggttgtt ctggaactag tatatttaac 6540
tcaatgatta ataatataat cattagaacc ttagttttgg atgcatataa acatattgat 6600
ttagataaac ttaaaataat tgcctatggt gatgatgtga tcttttctta caagtataaa 6660
ctagacatgg aagccatagc caaggaaggg cagaaatatg gacttactat aacacctgca 6720
gataaatcta gtgaattcaa agaacttgat tatggaaatg taacttttct taaaagagga 6780
tttagacaag atgataaata caaatttttg atacatccta cttttccagt tgaagagatt 6840
tatgagtcca ttagatggac aaagaaacca tctcaaatgc aggagcatgt cttatccttg 6900
tgtcacttaa tgtggcacaa tggtcctgag atttataagg actttgaaac aaagatacgc 6960
agtgtcagcg ctggacgtgc actgtatatc cctccttatg aactcctaag acatgaatgg 7020
tatgaaaaat tctagatata gaattaataa atgaatagtt tgttagtttt ataaaaaaaa 7080
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 7124
<210> 65
<211> 5978
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 65
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag atattgcctc acatccctta gccacaaccc tcattggtga gatagcaagt 1920
tactttacac actggacagg gagcctgcga ttcagtttca tgttttgcgg gactgcaaac 1980
actaccttaa aagttttgct agcatataca cccccaggga ttggtaagcc tagaagtaga 2040
aaggaagcaa tgttagggac acacgtggtg tgggatgtag gtttacaatc tacagtgtca 2100
ttggttgtac catggatcag tgccagtcag tatagattca ctacaccaga cacatactcc 2160
tcagcaggct acattacatg ctggtatcaa actaattttg ttgttccacc aaacacacct 2220
aacactgctg agatgttgtg ttttgtatct ggatgcaagg acttttgcct tcggatggca 2280
agagacacag acctgcacaa gcaaacagga ccaataacac aaaatccagt ggaaagatat 2340
gtagatgaag tcttaaatga agtgttagta gtgcccaata ttaatgagag ccaccctacc 2400
acatcaaatg cggccccagt tttggatgct gctgaaacag gacataccaa taagatacag 2460
ccagaagaca ctatagaaac cagatatgtg caatcttcac agacattgga tgaaatgagt 2520
gtggaaagct tcctaggcag atcggggtgc atccatgaat cagtgttgga tattgtggac 2580
aattacaatg atcaaagttt cactaaatgg aagataaacc tgcaagaaat ggcacaaatt 2640
agaagaaaat ttgaaatgtt tacttatgca agatttgact ctgaaattac tatggtacca 2700
agtgtagcag ccaaagatgg tcacattggt catatagtca tgcaatatat gtatgtacca 2760
ccaggagcac ctataccaac aactagaaat gactatgctt ggcaatctgg aacaaatgca 2820
tctgtatttt ggcagcatgg gcaacctttc cctcgctttt cacttccctt tttgagtatt 2880
gcatcagcat attacatgtt ttatgatggt tatgataagt gtgagataga tacattgcat 2940
gacttatcct gtaagttttt acctctgtat gccagtgaag caaagagaat taaagtgttg 3000
tatcacaagt gcactaacat aattaaacag aagaagagaa gtgaacctgt agcagttatg 3060
atacacgggc ctcctgggac cggaaaatca atcactacaa gcttcctggc tagaatgatt 3120
actaatgaga gtgacatata ctcacttcca ccagacccta aatattttga tggttatgat 3180
aaccagagtg tagtaataat ggatgacatc atgcaaaacc ctggtggtga ggacatgaca 3240
ttattctgtc agatggtatc tagtgtgact tttatacccc caatggctga tctaccagat 3300
aagggaaaac cctttgattc tagatttgta ttgtgtagta ctaatcactc actcttggca 3360
cccccaacta tatcgtcgct cccagcaatg aatagaagat tctatttaga tttagatatt 3420
cttgtgcatg ataactacaa agataatcag ggtaagttag atgtttctag agcatttcga 3480
ctatgtgatg ttgattcaaa gattggaaat gcaaaatgtt gtccatttgt atgtggcaag 3540
gcagtgacat tcaaggaccg caacacatgt agaacttatt cactttccca aatatacaac 3600
caaattcttg aggaagacaa gagaaggaga caggtggttg atgtcatgtc tgcaattttc 3660
caagggccta tatccatggg taaaccccca ccaccagcta taacagacct tttacactca 3720
gtaaggacac cagaagtaat taagtactgc caagacaata aatggatagt tcctgcggac 3780
tgccaaattg aaagggatct gaatatagct aatagcataa tcacaatcat agctaatatc 3840
atcagtatag cagggattat atatataatt tataagctct tttgctctct acagggccct 3900
tactcggggg agcccaaacc taagacaaaa gttcccgaga gaagagtggt agctcaaggt 3960
ccagaagaag aatttggaat gtctattatt aaaaataata cctgtgttgt gaccacaaca 4020
aatggaaaat ttacaggatt aggcatttat gacagaatct taatattacc aacacatgct 4080
gacccgggca gtgaaattca agtaaatgga atacacacca aagtgcttga ttcttatgac 4140
ttgtttaata aggaaggtgt caagttggaa attactgtgc taaagttaga tagaaatgag 4200
aagttcaggg atatacgtaa gtacatacct gaatcagaag atgactatcc tgaatgcaac 4260
ctagcactag tggccaatca aacagaacca actataatca aagtagggga tgttgtgtct 4320
tatggtaata tattacttag tggcacacag acagccagaa tgcttaaata taactatcct 4380
acaaaatctg ggtattgtgg tggtgtgtta tacaagattg gccagatctt aggtatacat 4440
gtgggtggca atggtagaga tgggttttca tctatgctat tgagatcata cttcactgaa 4500
caacaaggcc aaattcaaat ctctaaacat gttaaagatg ttggcttacc ctcaatacat 4560
acgccaacta aaactaaatt gcagccaagt gtcttctatg acatttttcc aggcagtaag 4620
gaaccagcag tcctcacaga aaaagatcct agattgaaag tggactttga ctcagctctt 4680
ttttcaaaat acaaaggtaa cacagagtgc agtttgaatg aacatataca agttgcagta 4740
gcacactact cagctcagct agcaacacta gatatagatc cacaaccaat tgcaatggaa 4800
gatagtgttt ttggaatgga tggcttggaa gctttggatc tgaatactag tgcaggttat 4860
ccctatgtaa cactaggaat taaaaagaaa gatcttatta ataacaagac taaagatatt 4920
tccaaactta agctagcatt agacaaatat ggtgttgatt tgcccatgat tactttctta 4980
aaagatgaac ttagaaagaa ggataagata gcagcaggca aaaccagagt tatagaagct 5040
agtagtataa atgataccat tttgtttaga acagtttatg gaaacctatt ttctaaattt 5100
cacttgaacc caggagtggt aacaggctgt gcagttggat gtgatccaga aaccttttgg 5160
tctaaaattc ccttgatgtt agatggagat tgcattatgg cttttgatta tacaaattat 5220
gatggtagca ttcatccaat ttggtttaaa gctctcggaa tggtacttga taatttatcc 5280
tttaacccta ctctaatcaa tagactttgt aaatcaaaac atattttcaa gtccacatat 5340
tatgaagttg aaggtggtgt gccctctggt tgttctggaa ctagtatatt taactcaatg 5400
attaataata taatcattag aaccttagtt ttggatgcat ataaacatat tgatttagat 5460
aaacttaaaa taattgccta tggtgatgat gtgatctttt cttacaagta taaactagac 5520
atggaagcca tagccaagga agggcagaaa tatggactta ctataacacc tgcagataaa 5580
tctagtgaat tcaaagaact tgattatgga aatgtaactt ttcttaaaag aggatttaga 5640
caagatgata aatacaaatt tttgatacat cctacttttc cagttgaaga gatttatgag 5700
tccattagat ggacaaagaa accatctcaa atgcaggagc atgtcttatc cttgtgtcac 5760
ttaatgtggc acaatggtcc tgagatttat aaggactttg aaacaaagat acgcagtgtc 5820
agcgctggac gtgcactgta tatccctcct tatgaactcc taagacatga atggtatgaa 5880
aaattctaga tatagaatta ataaatgaat agtttgttag ttttataaaa aaaaaaaaaa 5940
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 5978
<210> 66
<211> 7012
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 66
ttaaaactgg atctgggttg ttcccaccca gatcacctac atggtgttgt acactattat 60
tacggtaatc ttgtacgcca gttttatact ccctttccca aatgtaactt agaagcaaag 120
caaactgatc aataggggac aatcatccag attgtcaaag atcaagcact tctgtttccc 180
cggtcaaagt tgatatgctc cacaagggca aaaacaactg agatcgttat ccgcaagatg 240
cctacgcaaa gcctagtaat acattgaaag atacttggtt ggtcgctcag ctgttaaccc 300
aacagtagac ctggtagatg aggctagaga ttcccctccg gcgacggagt tctagcctgc 360
gtggctgcct gcacacccac tgggtgtgaa gccaagtatt ggacaaggtg tgaagagccg 420
cgtgtgctca tcttgagtcc tccggcccct gaatgtggct aaccttaaac ctgcagccag 480
tgcacacaat ccagtgtgta gctggtcgta atgagcaatt gcgggatggg accaactact 540
ttgggtgtcc gtgtttcact tttttccttt tattattgct tatggtgaca atatatatag 600
catatatata ttgttatcat gggcgctcaa gtatctagac agaatgttgg tacgcactca 660
acacaaaata tggtgtcaaa tggatccagc ctcaattatt ttaacatcaa ttatttcaaa 720
gatgcagctt ccagtggtgc ttctcgattg gacttctctc aagaccccag taaattcaca 780
gacccagtta aggatgtgtt ggagaaaggc atacccactc tgcaatctcc aagtgtagaa 840
gcttgtggat actctgatag aataatccaa attacaagag gcgactcaac cataacatct 900
caagatgttg ctaatgcagt ggttgggtat ggggtatggc cacactacct aactccgcag 960
gatgcaacgg ctatagacaa gccaacacaa ccagatacat catcaaatag gttttacaca 1020
ctggatagta aaatgtggaa cagtacctcc aaaggttggt ggtggaaact accagatgct 1080
cttaaagaca tgggtatttt tggtgaaaat atgttttatc atttcttggg tagaagtggt 1140
tatacagtgc acgtacagtg caatgcaagt aaattccacc agggtacact actagtggtt 1200
atgataccag aacaccagtt agctacagta aataaaggta atgttaatgc aggttacaaa 1260
tacacacatc ctggtgaagc tggtagagaa gtgggtacac aagttgaaaa tgagaaacaa 1320
cctagtgatg ataattggct aaattttgat ggtacattat tgggcaattt actgatattc 1380
ccacaccagt ttattaactt aaggagcaat aactcagcaa ctcttatagt accatatgtt 1440
aatgctgttc caatggattc tatggttaga cataacaatt ggagtttggt aataatacca 1500
gtttgtcaac tacaaagcaa caatatatcc aacattgttc ccatcactgt ttccattagc 1560
ccaatgtgtg ctgaattctc tggagcacgt gccaaaacag ttgtgcaagg tctaccagta 1620
tatgttacac caggatcagg acaattcatg acaacagatg atatgcaatc tccatgtgca 1680
ctgccttggt accatccaac aaaagagatc tttataccag gagaggttaa gaacttgatt 1740
gaaatgtgtc aggtggatac actcatacca ataaatagca cacagtctaa cattggcaat 1800
gtcagcatgt acacagtaac tctatcacca caaacaaaat tagctgaaga aatttttgca 1860
attaaagtag atattgcctc acatccctta gccacaaccc tcattggtga gatagcaagt 1920
tactttacac actggacagg gagcctgcga ttcagtttca tgttttgcgg gactgcaaac 1980
actaccttaa aagttttgct agcatataca cccccaggga ttggtaagcc tagaagtaga 2040
aaggaagcaa tgttagggac acacgtggtg tgggatgtag gtttacaatc tacagtgtca 2100
ttggttgtac catggatcag tgccagtcag tatagattca ctacaccaga cacatactcc 2160
tcagcaggct acattacatg ctggtatcaa actaattttg ttgttccacc aaacacacct 2220
aacactgctg agatgttgtg ttttgtatct ggatgcaagg acttttgcct tcggatggca 2280
agagacacag acctgcacaa gcaaacagga ccaataacac aaaatccagt ggaaagatat 2340
gtagatgaag tcttaaatga agtgttagta gtgcccaata ttaatgagag ccaccctacc 2400
acatcaaatg cggccccagt tttggatgct gctgaaacag gacataccaa taagatacag 2460
ccagaagaca ctatagaaac cagatatgtg caatcttcac agacattgga tgaaatgagt 2520
gtggaaagct tcctaggcag atcggggtgc atccatgaat cagtgttgga tattgtggac 2580
aattacaatg atcaaagttt cactaaatgg aagataaacc tgcaagaaat ggcacaaatt 2640
agaagaaaat ttgaaatgtt tacttatgca agatttgact ctgaaattac tatggtacca 2700
agtgtagcag ccaaagatgg tcacattggt catatagtca tgcaatatat gtatgtacca 2760
ccaggagcac ctataccaac aactagaaat gactatgctt ggcaatctgg aacaaatgca 2820
tctgtatttt ggcagcatgg gcaacctttc cctcgctttt cacttccctt tttgagtatt 2880
gcatcagcat attacatgtt ttatgatggt tatgatggag acacatataa atccagatat 2940
ggaactgtag tcaccaatga catgggaact ttgtgttcgc gtattgtgac cagtgagcaa 3000
ttacacaaag tcaaagtggt aacaaggata tatcacaaag ccaaacacac caaagcttgg 3060
tgcccaagac cacccagagc tgttcaatac tcacatacac ataccaccaa ctacaaattg 3120
agttcagaag tacacaatga tgtggctata agacctagaa caaatctaac aactgttggg 3180
cctagtgaca tgtatgtgca tgttggtaat ctaatataca gaaatctaca tttatttaac 3240
tctgacatac atgattccat tttagtgtct tattcatcag atttaatcat ataccgaaca 3300
agcacacaag gtgatgatta tattccaaca tgtaattgca ctgaagctac atattactgc 3360
aaacacaaaa acaggtacta cccaattaat gtcacacctc atgactggta tgagatacaa 3420
gagagtgaat attatccaaa acatatccag tacaatttac taataggtga aggaccatgt 3480
gaaccaggtg attgtggtgg gaaattatta tgcaaacatg gagtgatagg tattattaca 3540
gcaggtggtg agggccatgt tgcattcata gatcttagac actttcactg tgctgaagaa 3600
caaggaatca ctgattacat acacatgctc ggcgaagctt ttggcagtgg atttgtagat 3660
agtgttaaag accagattaa ttcaataaat cccatcaata acattagcag taagatggtt 3720
aaatggatgt taagaattat atcagctatg gttataatta ttagaaactc ttcagatccg 3780
caaacaataa ttgccacttt aacactgatt ggatgcaatg gttctccttg gagatttctc 3840
aaagaaaagt tctgtaaatg gactcaatta acttatatac acaaagaatc agattcatgg 3900
ctcaaaaaat tcactgagat gtgtaatgca gctagggggc tagaatggat tggaaacaaa 3960
atatccaaat ttatcgattg gatgaaatca atgctacccc aggcacaatt aaaagttaag 4020
tatttgagtg aacttaagaa actcaacttt ctggagaaac aggttgaaaa tctcagagca 4080
gctgatacta acactcaaga aaaaatcaag tgtgagatag atacattgca tgacttatcc 4140
tggctagaat gattactaat gagagtgaca tatactcact tccaccagac cctaaatatt 4200
ttgatggtta tgataaccag agtgtagtaa taatggatga catcatgcaa aaccctggtg 4260
gtgaggacat gacattattc tgtcagatgg tatctagtgt gacttttata cccccaatgg 4320
ctgatctacc agataaggga aaaccctttg attctagatt tgtattgtgt agtactaatc 4380
actcactctt ggcaccccca actatatcgt cgctcccagc aatgaataga agattctatt 4440
tagatttaga tattcttgtg catgataact acaaagataa tcagggtaag ttagatgttt 4500
ctagagcatt tcgactatgt gatgttgatt caaagattgg aaatgcaaaa tgttgtccat 4560
ttgtatgtgg caaggcagtg acattcaagg accgcaacac atgtagaact tattcacttt 4620
cccaaatata caaccaaatt cttgaggaag acaagagaag gagacaggtg gttgatgtca 4680
tgtctgcaat tttccaaggg cctatatcca tgggtaaacc cccaccacca gctataacag 4740
accttttaca ctcagtaagg acaccagaag taattaagta ctgccaagac aataaatgga 4800
tagttcctgc ggactgccaa attgaaaggg atctgaatat agctaatagc ataatcacaa 4860
tcatagctaa tatcatcagt atagcaggga ttatatatat aatttataag ctcttttgct 4920
ctctacaggg cccttactcg ggggagccca aacctaagac aaaagttccc gagagaagag 4980
tggtagctca aggtccagaa gaagaatttg gaatgtctat tattaaaaat aatacctgtg 5040
ttgtgaccac aacaaatgga aaatttacag gattaggcat ttatgacaga atcttaatat 5100
taccaacaca tgctgacccg ggcagtgaaa ttcaagtaaa tggaatacac accaaagtgc 5160
ttgattctta tgacttgttt aataaggaag gtgtcaagtt ggaaattact gtgctaaagt 5220
tagatagaaa tgagaagttc agggatatac gtaagtacat acctgaatca gaagatgact 5280
atcctgaatg caacctagca ctagtggcca atcaaacaga accaactata atcaaagtag 5340
gggatgttgt gtcttatggt aatatattac ttagtggcac acagacagcc agaatgctta 5400
aatataacta tcctacaaaa tctgggtatt gtggtggtgt gttatacaag attggccaga 5460
tcttaggtat acatgtgggt ggcaatggta gagatgggtt ttcatctatg ctattgagat 5520
catacttcac tgaacaacaa ggccaaattc aaatctctaa acatgttaaa gatgttggct 5580
taccctcaat acatacgcca actaaaacta aattgcagcc aagtgtcttc tatgacattt 5640
ttccaggcag taaggaacca gcagtcctca cagaaaaaga tcctagattg aaagtggact 5700
ttgactcagc tcttttttca aaatacaaag gtaacacaga gtgcagtttg aatgaacata 5760
tacaagttgc agtagcacac tactcagctc agctagcaac actagatata gatccacaac 5820
caattgcaat ggaagatagt gtttttggaa tggatggctt ggaagctttg gatctgaata 5880
ctagtgcagg ttatccctat gtaacactag gaattaaaaa gaaagatctt attaataaca 5940
agactaaaga tatttccaaa cttaagctag cattagacaa atatggtgtt gatttgccca 6000
tgattacttt cttaaaagat gaacttagaa agaaggataa gatagcagca ggcaaaacca 6060
gagttataga agctagtagt ataaatgata ccattttgtt tagaacagtt tatggaaacc 6120
tattttctaa atttcacttg aacccaggag tggtaacagg ctgtgcagtt ggatgtgatc 6180
cagaaacctt ttggtctaaa attcccttga tgttagatgg agattgcatt atggcttttg 6240
attatacaaa ttatgatggt agcattcatc caatttggtt taaagctctc ggaatggtac 6300
ttgataattt atcctttaac cctactctaa tcaatagact ttgtaaatca aaacatattt 6360
tcaagtccac atattatgaa gttgaaggtg gtgtgccctc tggttgttct ggaactagta 6420
tatttaactc aatgattaat aatataatca ttagaacctt agttttggat gcatataaac 6480
atattgattt agataaactt aaaataattg cctatggtga tgatgtgatc ttttcttaca 6540
agtataaact agacatggaa gccatagcca aggaagggca gaaatatgga cttactataa 6600
cacctgcaga taaatctagt gaattcaaag aacttgatta tggaaatgta acttttctta 6660
aaagaggatt tagacaagat gataaataca aatttttgat acatcctact tttccagttg 6720
aagagattta tgagtccatt agatggacaa agaaaccatc tcaaatgcag gagcatgtct 6780
tatccttgtg tcacttaatg tggcacaatg gtcctgagat ttataaggac tttgaaacaa 6840
agatacgcag tgtcagcgct ggacgtgcac tgtatatccc tccttatgaa ctcctaagac 6900
atgaatggta tgaaaaattc tagatataga attaataaat gaatagtttg ttagttttat 6960
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 7012
<210> 67
<211> 7223
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 67
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagaaag agctatgaat caagccagca tgattattaa 5100
tactattctg atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc 5160
tcaaactcaa ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt 5220
acgcccagtt gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa 5280
cataatgact ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt 5340
ctgtgtgata cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat 5400
tagagttaag gataagtaca aattagtaga tccagagaac attaatctag agcttacagt 5460
gttgacttta gatagaaatg aaaaattcag agatatcagg ggatttatat cagaagatct 5520
agaaggtgtg gatgccactt tggtagtaca ttcaaataac tttaccaaca ctatcttaga 5580
agttggccct gtaacaatgg caggacttat taatttgagt agcaccccca ctaacagaat 5640
gattcgttat gattatgcaa caaaaactgg gcagtgtgga ggtgtgctgt gtgctactgg 5700
taagatcttt ggtattcatg ttggcggtaa tggaagacaa ggattttcag ctcaacttaa 5760
aaaacaatat tttgtagaga aacaaggcca agtaatagct agacataagg ttagggagtt 5820
taacataaat ccagtcaaca cgccaaccaa gtcaaaatta catcccagtg tattctatga 5880
tgttttccca ggtgacaagg aacctgctgt attgagtgac aatgatccca gactggaagt 5940
taaattgact gaatcattat tctctaagta caaggggaat gtaaatacgg aacccactga 6000
aaatatgctt gtggctgtag accattatgc agggcaacta ttatcactag atatccccac 6060
ttctgaactt acactaaaag aagcattata tggagtagat ggactagaac ctatagatat 6120
tacaaccagt gcaggatttc cctatgtgag tcttgggatc aaaaagagag acattctgaa 6180
taaagagacc caggacacag aaaagatgaa gttttatcta gacaagtatg gcattgactt 6240
gcctctagtt acatatatta aggatgaatt aagaagtgtt gacaaagtcc gattagggaa 6300
aagtagatta attgaagcct ccagtttgaa tgattctgtt aacatgagaa tgaaactagg 6360
caacctttac aaagcattcc atcaaaatcc cggtgttctg actggatcag cagtgggttg 6420
tgatcctgat gtgttttggt ctgtcatccc ttgcttaatg gatgggcacc tgatggcatt 6480
tgattactct aattttgatg cctctttgtc accagtttgg tttgtctgtc tagagaaggt 6540
tttgaccaag ttaggctttg caggctcttc attaattcaa tcaatttgta atacccatca 6600
tatctttagg gatgaaatat atgtggttga aggtggcatg ccctcagggt gttcaggaac 6660
cagcatattc aattccatga tcaacaacat aatcattagg actttgatat tagatgcata 6720
taaaggaata gatttagaca aacttaaaat cttagcttac ggtgatgatt tgattgtttc 6780
ttatccttat gaactggatc cgcaagtgtt ggcaactctt ggtaaaaatt atggactaac 6840
catcacaccc ccagacaaat ctgaaacttt tacaaaaatg acatgggaaa acttgacatt 6900
tttaaagaga tacttcaagc ctgatcaaca atttcccttt ttggttcacc cagttatgcc 6960
catgaaagat atacatgagt caatcagatg gacaaaggat cctaaaaaca cacaggatca 7020
cgtccgatca ttatgcatgt tagcatggca ctcaggagaa aaagagtaca atgaattcat 7080
tcagaagatc agaactactg acattggaaa atgtctaatt ctcccagaat acagcgtact 7140
taggaggcgc tggttggacc tcttttaggt taacaatata gacacttaat ttgagtagaa 7200
gtaggagttt ataaaaaaaa aaa 7223
<210> 68
<211> 6014
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 68
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaaagctta ggctgatgaa 1080
agatactcaa actatctcac agactgttgc actcactgaa ggcttaggtg atgaattaga 1140
agaagtcatc gttgagaaaa cgaaacagac ggtggcctca atctcatctg gtccaaaaca 1200
cacacaaaaa gtccccatac taactgcaaa cgaaacaggg gccacaatgc ctgttcttcc 1260
atcagacagc atagaaacca gaactaccta catgcacttt aatggttcag aaactgatgt 1320
agaatgcttt ttgggtcgtg cagcttgtgt gcatgtaact gaaatacaaa acaaagatgc 1380
tactggaata gataatcaca gagaagcaaa attgttcaat gattggaaaa tcaacctgtc 1440
cagccttgtc caacttagaa agaaactaga actcttcact tatgttaggt ttgattctga 1500
gtataccata ctggccactg catctcaacc tgattcagca aactattcaa gcaatttggt 1560
ggtccaagcc atgtatgttc cacctggtgc cccgaatcca aaagagtggg acgattacac 1620
atggcaaagt gcttcaaacc ccagtgtatt cttcaaggtg ggggatacat ccaggtttag 1680
tgtgccttat gtaggattgg catcagcata taattgtttt tatgatggtt actcacatga 1740
tgatgcagaa actcagtatg gcataactgt tctaaaccat atgggtagta tggcattcag 1800
aatagtaaat gaacatgatg aacataaaac tcttgtcaag atcagagttt atcacagggc 1860
aaagcacgtt gaagcatgga ttccaagagc acccagagca ctaccctaca catcaatagg 1920
gcgcacaaat tatcctaaga atacagaacc agtaattaag aagaggaaag gtgacattaa 1980
atcctatggt ttaggaccta ggtacggtgg gatttataca tcaaatgtta aaataatgaa 2040
ttaccacttg atgacaccag aagaccacca taatctgata gcaccctatc caaatagaga 2100
tttagcaata gtctcaacag gaggacatgg tgcagaaaca ataccacact gtaactgtac 2160
atcaggtgtt tactattcca catattacag aaagtattac cccataattt gtgaaaagcc 2220
caccaacatc tggattgaag gaaaccctta ttacccaagt agatttcaag caggagtgat 2280
gaaaggggtt gggccagcag aaccaggaga ctgcggtggg attttgagat gcatacatgg 2340
tcccattgga ttgttaacag ctggaggtag tggatatgtt tgttttgctg acatacgaca 2400
gttggagtgt atcgcagagg aacaggggct gagtgattac atcacaggtt tgggtagagc 2460
ttttggtgtc gggttcactg accaaatctc aacaaaagtc acagaactac aagaagtggc 2520
gaaagatttc ctcaccacaa aagttttgtc caaagtggtc aaaatggttt cagctttagt 2580
gatcatttgc agaaatcatg atgacttggt cactgttacg gccactctag cactacttgg 2640
atgtgatgga tctccctgga gatttctgaa gatgtacatt tccaaacact ttcaggtgcc 2700
ttacattgaa agacaagcaa atgatggatg gttcagaaag tttaatgatg catgtaatgc 2760
tgcaaaggga ttggaatgga ttgctaataa gatttccaaa ctgattgaat ggataaaaaa 2820
caaagtactt ccccaagcca aagaaaaact agaattttgt agtaaactca aacaacttga 2880
tatactagag agacaaataa ccaccatgca tatctcgaat ccaacacagg aaaaacgaga 2940
gcagttgttc aacaacgtat tgtggttgga acaaatgtcg caaaagtttg ccccacatta 3000
tgccgttgaa tcaaaaagaa tcagggaact caagaacaaa atggtaaatt atatgcaatt 3060
taaaagtaaa caaagaactg aaccagtgtg tgtattaatc catggtacac ccggttctgg 3120
taaatcatta acaacatcca ttgtgggacg tgcaattgca gaacacttca attcagcagt 3180
atattcactt ccaccagatc ccaagcactt tgatggttat cagcaacagg aagttgtgat 3240
tatggatgat ctgaaccaaa atccagacgg acaggatata agcatgtttt gtcaaatggt 3300
ttcttcagtg gatttcttgc ctccaatggc tagtttagat aacaagggca tgttattcac 3360
cagtaatttt gttctagcct ccacaaattc taacacacta agccccccaa caatcttgaa 3420
tcctgaagct ttagtcagga gatttggttt tgacctggat atatgtttgc atactaccta 3480
cacaaagaat ggaaaactca atgcaggcat gtcaaccaag acatgcaaag attgccatca 3540
accatctaat ttcaagaaat gttgccccct ggtctgtgga aaagctatta gcttggtaga 3600
cagaactacc aacgttaggt atagtgtgga tcaactggtc acagctatta taagtgattt 3660
caagagcaaa atgcaaatta cagattccct agaaacactg tttcaaggac cagtgtataa 3720
agatttagag attgatgttt gcaacacacc acctccagaa tgtatcaacg atttactgaa 3780
atctgtagat tcagaagaga ttagggaata ttgtaagaag aagaaatgga ttatacctga 3840
aattcctacc aacatagaaa gagctatgaa tcaagccagc atgattatta atactattct 3900
gatgtttgtc agtacattag gtattgttta tgtcatttat aaattgtttg ctcaaactca 3960
aggaccatat tctggtaacc cgcctcacaa taaactaaaa gccccaactt tacgcccagt 4020
tgttgtgcaa ggaccaaaca cagaatttgc actatccctg ttaaggaaaa acataatgac 4080
tataacaacc tcaaagggag agttcacagg gttaggcata catgatcgtg tctgtgtgat 4140
acccacacac gcacagcctg gtgatgatgt actagtgaat ggtcagaaaa ttagagttaa 4200
ggataagtac aaattagtag atccagagaa cattaatcta gagcttacag tgttgacttt 4260
agatagaaat gaaaaattca gagatatcag gggatttata tcagaagatc tagaaggtgt 4320
ggatgccact ttggtagtac attcaaataa ctttaccaac actatcttag aagttggccc 4380
tgtaacaatg gcaggactta ttaatttgag tagcaccccc actaacagaa tgattcgtta 4440
tgattatgca acaaaaactg ggcagtgtgg aggtgtgctg tgtgctactg gtaagatctt 4500
tggtattcat gttggcggta atggaagaca aggattttca gctcaactta aaaaacaata 4560
ttttgtagag aaacaaggcc aagtaatagc tagacataag gttagggagt ttaacataaa 4620
tccagtcaac acgccaacca agtcaaaatt acatcccagt gtattctatg atgttttccc 4680
aggtgacaag gaacctgctg tattgagtga caatgatccc agactggaag ttaaattgac 4740
tgaatcatta ttctctaagt acaaggggaa tgtaaatacg gaacccactg aaaatatgct 4800
tgtggctgta gaccattatg cagggcaact attatcacta gatatcccca cttctgaact 4860
tacactaaaa gaagcattat atggagtaga tggactagaa cctatagata ttacaaccag 4920
tgcaggattt ccctatgtga gtcttgggat caaaaagaga gacattctga ataaagagac 4980
ccaggacaca gaaaagatga agttttatct agacaagtat ggcattgact tgcctctagt 5040
tacatatatt aaggatgaat taagaagtgt tgacaaagtc cgattaggga aaagtagatt 5100
aattgaagcc tccagtttga atgattctgt taacatgaga atgaaactag gcaaccttta 5160
caaagcattc catcaaaatc ccggtgttct gactggatca gcagtgggtt gtgatcctga 5220
tgtgttttgg tctgtcatcc cttgcttaat ggatgggcac ctgatggcat ttgattactc 5280
taattttgat gcctctttgt caccagtttg gtttgtctgt ctagagaagg ttttgaccaa 5340
gttaggcttt gcaggctctt cattaattca atcaatttgt aatacccatc atatctttag 5400
ggatgaaata tatgtggttg aaggtggcat gccctcaggg tgttcaggaa ccagcatatt 5460
caattccatg atcaacaaca taatcattag gactttgata ttagatgcat ataaaggaat 5520
agatttagac aaacttaaaa tcttagctta cggtgatgat ttgattgttt cttatcctta 5580
tgaactggat ccgcaagtgt tggcaactct tggtaaaaat tatggactaa ccatcacacc 5640
cccagacaaa tctgaaactt ttacaaaaat gacatgggaa aacttgacat ttttaaagag 5700
atacttcaag cctgatcaac aatttccctt tttggttcac ccagttatgc ccatgaaaga 5760
tatacatgag tcaatcagat ggacaaagga tcctaaaaac acacaggatc acgtccgatc 5820
attatgcatg ttagcatggc actcaggaga aaaagagtac aatgaattca ttcagaagat 5880
cagaactact gacattggaa aatgtctaat tctcccagaa tacagcgtac ttaggaggcg 5940
ctggttggac ctcttttagg ttaacaatat agacacttaa tttgagtaga agtaggagtt 6000
tataaaaaaa aaaa 6014
<210> 69
<211> 6013
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 69
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaagcttag gctgatgaaa 1080
gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga tgaattagaa 1140
gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg tccaaaacac 1200
acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc tgttcttcca 1260
tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga aactgatgta 1320
gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa caaagatgct 1380
actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat caacctgtcc 1440
agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt tgattctgag 1500
tataccatac tggccactgc atctcaacct gattcagcaa actattcaag caatttggtg 1560
gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga cgattacaca 1620
tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc caggtttagt 1680
gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta ctcacatgat 1740
gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat ggcattcaga 1800
atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta tcacagggca 1860
aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac atcaataggg 1920
cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg tgacattaaa 1980
tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa aataatgaat 2040
taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc aaatagagat 2100
ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg taactgtaca 2160
tcaggtgttt actattccac atattacaga aagtattacc ccataatttg tgaaaagccc 2220
accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc aggagtgatg 2280
aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg catacatggt 2340
cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga catacgacag 2400
ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt gggtagagct 2460
tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca agaagtggcg 2520
aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc agctttagtg 2580
atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc actacttgga 2640
tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt tcaggtgcct 2700
tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc atgtaatgct 2760
gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg gataaaaaac 2820
aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa acaacttgat 2880
atactagaga gacaaataac caccatgcat atctcgaatc caacacagga aaaacgagag 2940
cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc cccacattat 3000
gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta tatgcaattt 3060
aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc cggttctggt 3120
aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa ttcagcagta 3180
tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga agttgtgatt 3240
atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg tcaaatggtt 3300
tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat gttattcacc 3360
agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac aatcttgaat 3420
cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca tactacctac 3480
acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga ttgccatcaa 3540
ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag cttggtagac 3600
agaactacca acgttaggta tagtgtggat caactggtca cagctattat aagtgatttc 3660
aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc agtgtataaa 3720
gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga tttactgaaa 3780
tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat tatacctgaa 3840
attcctacca acatagaaag agctatgaat caagccagca tgattattaa tactattctg 3900
atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc tcaaactcaa 3960
ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt acgcccagtt 4020
gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa cataatgact 4080
ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt ctgtgtgata 4140
cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat tagagttaag 4200
gataagtaca aattagtaga tccagagaac attaatctag agcttacagt gttgacttta 4260
gatagaaatg aaaaattcag agatatcagg ggatttatat cagaagatct agaaggtgtg 4320
gatgccactt tggtagtaca ttcaaataac tttaccaaca ctatcttaga agttggccct 4380
gtaacaatgg caggacttat taatttgagt agcaccccca ctaacagaat gattcgttat 4440
gattatgcaa caaaaactgg gcagtgtgga ggtgtgctgt gtgctactgg taagatcttt 4500
ggtattcatg ttggcggtaa tggaagacaa ggattttcag ctcaacttaa aaaacaatat 4560
tttgtagaga aacaaggcca agtaatagct agacataagg ttagggagtt taacataaat 4620
ccagtcaaca cgccaaccaa gtcaaaatta catcccagtg tattctatga tgttttccca 4680
ggtgacaagg aacctgctgt attgagtgac aatgatccca gactggaagt taaattgact 4740
gaatcattat tctctaagta caaggggaat gtaaatacgg aacccactga aaatatgctt 4800
gtggctgtag accattatgc agggcaacta ttatcactag atatccccac ttctgaactt 4860
acactaaaag aagcattata tggagtagat ggactagaac ctatagatat tacaaccagt 4920
gcaggatttc cctatgtgag tcttgggatc aaaaagagag acattctgaa taaagagacc 4980
caggacacag aaaagatgaa gttttatcta gacaagtatg gcattgactt gcctctagtt 5040
acatatatta aggatgaatt aagaagtgtt gacaaagtcc gattagggaa aagtagatta 5100
attgaagcct ccagtttgaa tgattctgtt aacatgagaa tgaaactagg caacctttac 5160
aaagcattcc atcaaaatcc cggtgttctg actggatcag cagtgggttg tgatcctgat 5220
gtgttttggt ctgtcatccc ttgcttaatg gatgggcacc tgatggcatt tgattactct 5280
aattttgatg cctctttgtc accagtttgg tttgtctgtc tagagaaggt tttgaccaag 5340
ttaggctttg caggctcttc attaattcaa tcaatttgta atacccatca tatctttagg 5400
gatgaaatat atgtggttga aggtggcatg ccctcagggt gttcaggaac cagcatattc 5460
aattccatga tcaacaacat aatcattagg actttgatat tagatgcata taaaggaata 5520
gatttagaca aacttaaaat cttagcttac ggtgatgatt tgattgtttc ttatccttat 5580
gaactggatc cgcaagtgtt ggcaactctt ggtaaaaatt atggactaac catcacaccc 5640
ccagacaaat ctgaaacttt tacaaaaatg acatgggaaa acttgacatt tttaaagaga 5700
tacttcaagc ctgatcaaca atttcccttt ttggttcacc cagttatgcc catgaaagat 5760
atacatgagt caatcagatg gacaaaggat cctaaaaaca cacaggatca cgtccgatca 5820
ttatgcatgt tagcatggca ctcaggagaa aaagagtaca atgaattcat tcagaagatc 5880
agaactactg acattggaaa atgtctaatt ctcccagaat acagcgtact taggaggcgc 5940
tggttggacc tcttttaggt taacaatata gacacttaat ttgagtagaa gtaggagttt 6000
ataaaaaaaa aaa 6013
<210> 70
<211> 6767
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 70
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 71
<211> 6766
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 71
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atatacagaa 2700
ccagtaatta agaagaggaa aggtgacatt aaatcctatg gtttaggacc taggtacggt 2760
gggatttata catcaaatgt taaaataatg aattaccact tgatgacacc agaagaccac 2820
cataatctga tagcacccta tccaaataga gatttagcaa tagtctcaac aggaggacat 2880
ggtgcagaaa caataccaca ctgtaactgt acatcaggtg tttactattc cacatattac 2940
agaaagtatt accccataat ttgtgaaaag cccaccaaca tctggattga aggaaaccct 3000
tattacccaa gtagatttca agcaggagtg atgaaagggg ttgggccagc agaaccagga 3060
gactgcggtg ggattttgag atgcatacat ggtcccattg gattgttaac agctggaggt 3120
agtggatatg tttgttttgc tgacatacga cagttggagt gtatcgcaga ggaacagggg 3180
ctgagtgatt acatcacagg tttgggtaga gcttttggtg tcgggttcac tgaccaaatc 3240
tcaacaaaag tcacagaact acaagaagtg gcgaaagatt tcctcaccac aaaagttttg 3300
tccaaagtgg tcaaaatggt ttcagcttta gtgatcattt gcagaaatca tgatgacttg 3360
gtcactgtta cggccactct agcactactt ggatgtgatg gatctccctg gagatttctg 3420
aagatgtaca tttccaaaca ctttcaggtg ccttacattg aaagacaagc aaatgatgga 3480
tggttcagaa agtttaatga tgcatgtaat gctgcaaagg gattggaatg gattgctaat 3540
aagatttcca aactgattga atggataaaa aacaaagtac ttccccaagc caaagaaaaa 3600
ctagaatttt gtagtaaact caaacaactt gatatactag agagacaaat aaccaccatg 3660
catatctcga atccaacaca ggaaaaacga gagcagttgt tcaacaacgt attgtggttg 3720
gaacaaatgt cgcaaaagtt tgccccacat tatgccgttg aatcaaaaag aatcagggaa 3780
ctcaagaaca aaatggtaaa ttatatgcaa tttaaaagta aacaaagaac tgaaccagtg 3840
tgtgtattaa tccatggtac acccggttct ggtaaatcat taacaacatc cattgtggga 3900
cgtgcaattg cagaacactt caattcagca gtatattcac ttccaccaga tcccaagcac 3960
tttgatggtt atcagcaaca ggaagttgtg attatggatg atctgaacca aaatccagac 4020
ggacaggata taagcatgtt ttgtcaaatg gtttcttcag tggatttctt gcctccaatg 4080
gctagtttag ataacaaggg catgttattc accagtaatt ttgttctagc ctccacaaat 4140
tctaacacac taagcccccc aacaatcttg aatcctgaag ctttagtcag gagatttggt 4200
tttgacctgg atatatgttt gcatactacc tacacaaaga atggaaaact caatgcaggc 4260
atgtcaacca agacatgcaa agattgccat caaccatcta atttcaagaa atgttgcccc 4320
ctggtctgtg gaaaagctat tagcttggta gacagaacta ccaacgttag gtatagtgtg 4380
gatcaactgg tcacagctat tataagtgat ttcaagagca aaatgcaaat tacagattcc 4440
ctagaaacac tgtttcaagg accagtgtat aaagatttag agattgatgt ttgcaacaca 4500
ccacctccag aatgtatcaa cgatttactg aaatctgtag attcagaaga gattagggaa 4560
tattgtaaga agaagaaatg gattatacct gaaattccta ccaacataga aagagctatg 4620
aatcaagcca gcatgattat taatactatt ctgatgtttg tcagtacatt aggtattgtt 4680
tatgtcattt ataaattgtt tgctcaaact caaggaccat attctggtaa cccgcctcac 4740
aataaactaa aagccccaac tttacgccca gttgttgtgc aaggaccaaa cacagaattt 4800
gcactatccc tgttaaggaa aaacataatg actataacaa cctcaaaggg agagttcaca 4860
gggttaggca tacatgatcg tgtctgtgtg atacccacac acgcacagcc tggtgatgat 4920
gtactagtga atggtcagaa aattagagtt aaggataagt acaaattagt agatccagag 4980
aacattaatc tagagcttac agtgttgact ttagatagaa atgaaaaatt cagagatatc 5040
aggggattta tatcagaaga tctagaaggt gtggatgcca ctttggtagt acattcaaat 5100
aactttacca acactatctt agaagttggc cctgtaacaa tggcaggact tattaatttg 5160
agtagcaccc ccactaacag aatgattcgt tatgattatg caacaaaaac tgggcagtgt 5220
ggaggtgtgc tgtgtgctac tggtaagatc tttggtattc atgttggcgg taatggaaga 5280
caaggatttt cagctcaact taaaaaacaa tattttgtag agaaacaagg ccaagtaata 5340
gctagacata aggttaggga gtttaacata aatccagtca acacgccaac caagtcaaaa 5400
ttacatccca gtgtattcta tgatgttttc ccaggtgaca aggaacctgc tgtattgagt 5460
gacaatgatc ccagactgga agttaaattg actgaatcat tattctctaa gtacaagggg 5520
aatgtaaata cggaacccac tgaaaatatg cttgtggctg tagaccatta tgcagggcaa 5580
ctattatcac tagatatccc cacttctgaa cttacactaa aagaagcatt atatggagta 5640
gatggactag aacctataga tattacaacc agtgcaggat ttccctatgt gagtcttggg 5700
atcaaaaaga gagacattct gaataaagag acccaggaca cagaaaagat gaagttttat 5760
ctagacaagt atggcattga cttgcctcta gttacatata ttaaggatga attaagaagt 5820
gttgacaaag tccgattagg gaaaagtaga ttaattgaag cctccagttt gaatgattct 5880
gttaacatga gaatgaaact aggcaacctt tacaaagcat tccatcaaaa tcccggtgtt 5940
ctgactggat cagcagtggg ttgtgatcct gatgtgtttt ggtctgtcat cccttgctta 6000
atggatgggc acctgatggc atttgattac tctaattttg atgcctcttt gtcaccagtt 6060
tggtttgtct gtctagagaa ggttttgacc aagttaggct ttgcaggctc ttcattaatt 6120
caatcaattt gtaataccca tcatatcttt agggatgaaa tatatgtggt tgaaggtggc 6180
atgccctcag ggtgttcagg aaccagcata ttcaattcca tgatcaacaa cataatcatt 6240
aggactttga tattagatgc atataaagga atagatttag acaaacttaa aatcttagct 6300
tacggtgatg atttgattgt ttcttatcct tatgaactgg atccgcaagt gttggcaact 6360
cttggtaaaa attatggact aaccatcaca cccccagaca aatctgaaac ttttacaaaa 6420
atgacatggg aaaacttgac atttttaaag agatacttca agcctgatca acaatttccc 6480
tttttggttc acccagttat gcccatgaaa gatatacatg agtcaatcag atggacaaag 6540
gatcctaaaa acacacagga tcacgtccga tcattatgca tgttagcatg gcactcagga 6600
gaaaaagagt acaatgaatt cattcagaag atcagaacta ctgacattgg aaaatgtcta 6660
attctcccag aatacagcgt acttaggagg cgctggttgg acctctttta ggttaacaat 6720
atagacactt aatttgagta gaagtaggag tttataaaaa aaaaaa 6766
<210> 72
<211> 6767
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 72
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttactca aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 73
<211> 6767
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 73
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaaggc tcaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 74
<211> 6767
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 74
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcctcgatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 75
<211> 6767
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 75
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
agacctccca gaatacagcg tacttaggga ccgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 76
<211> 6767
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 76
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt ataatacaga 2700
accagtaatt aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg 2760
tgggatttat acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca 2820
ccataatctg atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca 2880
tggtgcagaa acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta 2940
cagaaagtat taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc 3000
ttattaccca agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg 3060
agactgcggt gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg 3120
tagtggatat gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg 3180
gctgagtgat tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat 3240
ctcaacaaaa gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt 3300
gtccaaagtg gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt 3360
ggtcactgtt acggccactc tagcactact tggatgtgat ggatctccct ggagatttct 3420
gaagatgtac atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg 3480
atggttcaga aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa 3540
taagatttcc aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa 3600
actagaattt tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat 3660
gcatatctcg aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt 3720
ggaacaaatg tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga 3780
actcaagaac aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt 3840
gtgtgtatta atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg 3900
acgtgcaatt gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca 3960
ctttgatggt tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga 4020
cggacaggat ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat 4080
ggctagttta gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa 4140
ttctaacaca ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg 4200
ttttgacctg gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg 4260
catgtcaacc aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc 4320
cctggtctgt ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt 4380
ggatcaactg gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc 4440
cctagaaaca ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac 4500
accacctcca gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga 4560
atattgtaag aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat 4620
gaatcaagcc agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt 4680
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 4740
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 4800
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 4860
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 4920
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 4980
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5040
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5100
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5160
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5220
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5280
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5340
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5400
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5460
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5520
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 5580
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 5640
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 5700
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 5760
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 5820
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 5880
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 5940
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6000
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6060
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6120
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6180
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6240
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6300
ttacggtgcg gcgttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6360
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6420
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6480
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6540
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 6600
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 6660
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 6720
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 6767
<210> 77
<211> 5558
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 77
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaaagctta ggctgatgaa 1080
agatactcaa actatctcac agactgttgc actcactgaa ggcttaggtg atgaattaga 1140
agaagtcatc gttgagaaaa cgaaacagac ggtggcctca atctcatctg gtccaaaaca 1200
cacacaaaaa gtccccatac taactgcaaa cgaaacaggg gccacaatgc ctgttcttcc 1260
atcagacagc atagaaacca gaactaccta catgcacttt aatggttcag aaactgatgt 1320
agaatgcttt ttgggtcgtg cagcttgtgt gcatgtaact gaaatacaaa acaaagatgc 1380
tactggaata gataatcaca gagaagcaaa attgttcaat gattggaaaa tcaacctgtc 1440
cagccttgtc caacttagaa agaaactaga actcttcact tataatacag aaccagtaat 1500
taagaagagg aaaggtgaca ttaaatccta tggtttagga cctaggtacg gtgggattta 1560
tacatcaaat gttaaaataa tgaattacca cttgatgaca ccagaagacc accataatct 1620
gatagcaccc tatccaaata gagatttagc aatagtctca acaggaggac atggtgcaga 1680
aacaatacca cactgtaact gtacatcagg tgtttactat tccacatatt acagaaagta 1740
ttaccccata atttgtgaaa agcccaccaa catctggatt gaaggaaacc cttattaccc 1800
aagtagattt caagcaggag tgatgaaagg ggttgggcca gcagaaccag gagactgcgg 1860
tgggattttg agatgcatac atggtcccat tggattgtta acagctggag gtagtggata 1920
tgtttgtttt gctgacatac gacagttgga gtgtatcgca gaggaacagg ggctgagtga 1980
ttacatcaca ggtttgggta gagcttttgg tgtcgggttc actgaccaaa tctcaacaaa 2040
agtcacagaa ctacaagaag tggcgaaaga tttcctcacc acaaaagttt tgtccaaagt 2100
ggtcaaaatg gtttcagctt tagtgatcat ttgcagaaat catgatgact tggtcactgt 2160
tacggccact ctagcactac ttggatgtga tggatctccc tggagatttc tgaagatgta 2220
catttccaaa cactttcagg tgccttacat tgaaagacaa gcaaatgatg gatggttcag 2280
aaagtttaat gatgcatgta atgctgcaaa gggattggaa tggattgcta ataagatttc 2340
caaactgatt gaatggataa aaaacaaagt acttccccaa gccaaagaaa aactagaatt 2400
ttgtagtaaa ctcaaacaac ttgatatact agagagacaa ataaccacca tgcatatctc 2460
gaatccaaca caggaaaaac gagagcagtt gttcaacaac gtattgtggt tggaacaaat 2520
gtcgcaaaag tttgccccac attatgccgt tgaatcaaaa agaatcaggg aactcaagaa 2580
caaaatggta aattatatgc aatttaaaag taaacaaaga actgaaccag tgtgtgtatt 2640
aatccatggt acacccggtt ctggtaaatc attaacaaca tccattgtgg gacgtgcaat 2700
tgcagaacac ttcaattcag cagtatattc acttccacca gatcccaagc actttgatgg 2760
ttatcagcaa caggaagttg tgattatgga tgatctgaac caaaatccag acggacagga 2820
tataagcatg ttttgtcaaa tggtttcttc agtggatttc ttgcctccaa tggctagttt 2880
agataacaag ggcatgttat tcaccagtaa ttttgttcta gcctccacaa attctaacac 2940
actaagcccc ccaacaatct tgaatcctga agctttagtc aggagatttg gttttgacct 3000
ggatatatgt ttgcatacta cctacacaaa gaatggaaaa ctcaatgcag gcatgtcaac 3060
caagacatgc aaagattgcc atcaaccatc taatttcaag aaatgttgcc ccctggtctg 3120
tggaaaagct attagcttgg tagacagaac taccaacgtt aggtatagtg tggatcaact 3180
ggtcacagct attataagtg atttcaagag caaaatgcaa attacagatt ccctagaaac 3240
actgtttcaa ggaccagtgt ataaagattt agagattgat gtttgcaaca caccacctcc 3300
agaatgtatc aacgatttac tgaaatctgt agattcagaa gagattaggg aatattgtaa 3360
gaagaagaaa tggattatac ctgaaattcc taccaacata gaaagagcta tgaatcaagc 3420
cagcatgatt attaatacta ttctgatgtt tgtcagtaca ttaggtattg tttatgtcat 3480
ttataaattg tttgctcaaa ctcaaggacc atattctggt aacccgcctc acaataaact 3540
aaaagcccca actttacgcc cagttgttgt gcaaggacca aacacagaat ttgcactatc 3600
cctgttaagg aaaaacataa tgactataac aacctcaaag ggagagttca cagggttagg 3660
catacatgat cgtgtctgtg tgatacccac acacgcacag cctggtgatg atgtactagt 3720
gaatggtcag aaaattagag ttaaggataa gtacaaatta gtagatccag agaacattaa 3780
tctagagctt acagtgttga ctttagatag aaatgaaaaa ttcagagata tcaggggatt 3840
tatatcagaa gatctagaag gtgtggatgc cactttggta gtacattcaa ataactttac 3900
caacactatc ttagaagttg gccctgtaac aatggcagga cttattaatt tgagtagcac 3960
ccccactaac agaatgattc gttatgatta tgcaacaaaa actgggcagt gtggaggtgt 4020
gctgtgtgct actggtaaga tctttggtat tcatgttggc ggtaatggaa gacaaggatt 4080
ttcagctcaa cttaaaaaac aatattttgt agagaaacaa ggccaagtaa tagctagaca 4140
taaggttagg gagtttaaca taaatccagt caacacgcca accaagtcaa aattacatcc 4200
cagtgtattc tatgatgttt tcccaggtga caaggaacct gctgtattga gtgacaatga 4260
tcccagactg gaagttaaat tgactgaatc attattctct aagtacaagg ggaatgtaaa 4320
tacggaaccc actgaaaata tgcttgtggc tgtagaccat tatgcagggc aactattatc 4380
actagatatc cccacttctg aacttacact aaaagaagca ttatatggag tagatggact 4440
agaacctata gatattacaa ccagtgcagg atttccctat gtgagtcttg ggatcaaaaa 4500
gagagacatt ctgaataaag agacccagga cacagaaaag atgaagtttt atctagacaa 4560
gtatggcatt gacttgcctc tagttacata tattaaggat gaattaagaa gtgttgacaa 4620
agtccgatta gggaaaagta gattaattga agcctccagt ttgaatgatt ctgttaacat 4680
gagaatgaaa ctaggcaacc tttacaaagc attccatcaa aatcccggtg ttctgactgg 4740
atcagcagtg ggttgtgatc ctgatgtgtt ttggtctgtc atcccttgct taatggatgg 4800
gcacctgatg gcatttgatt actctaattt tgatgcctct ttgtcaccag tttggtttgt 4860
ctgtctagag aaggttttga ccaagttagg ctttgcaggc tcttcattaa ttcaatcaat 4920
ttgtaatacc catcatatct ttagggatga aatatatgtg gttgaaggtg gcatgccctc 4980
agggtgttca ggaaccagca tattcaattc catgatcaac aacataatca ttaggacttt 5040
gatattagat gcatataaag gaatagattt agacaaactt aaaatcttag cttacggtga 5100
tgatttgatt gtttcttatc cttatgaact ggatccgcaa gtgttggcaa ctcttggtaa 5160
aaattatgga ctaaccatca cacccccaga caaatctgaa acttttacaa aaatgacatg 5220
ggaaaacttg acatttttaa agagatactt caagcctgat caacaatttc cctttttggt 5280
tcacccagtt atgcccatga aagatataca tgagtcaatc agatggacaa aggatcctaa 5340
aaacacacag gatcacgtcc gatcattatg catgttagca tggcactcag gagaaaaaga 5400
gtacaatgaa ttcattcaga agatcagaac tactgacatt ggaaaatgtc taattctccc 5460
agaatacagc gtacttagga ggcgctggtt ggacctcttt taggttaaca atatagacac 5520
ttaatttgag tagaagtagg agtttataaa aaaaaaaa 5558
<210> 78
<211> 5557
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 78
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaaagctta ggctgatgaa 1080
agatactcaa actatctcac agactgttgc actcactgaa ggcttaggtg atgaattaga 1140
agaagtcatc gttgagaaaa cgaaacagac ggtggcctca atctcatctg gtccaaaaca 1200
cacacaaaaa gtccccatac taactgcaaa cgaaacaggg gccacaatgc ctgttcttcc 1260
atcagacagc atagaaacca gaactaccta catgcacttt aatggttcag aaactgatgt 1320
agaatgcttt ttgggtcgtg cagcttgtgt gcatgtaact gaaatacaaa acaaagatgc 1380
tactggaata gataatcaca gagaagcaaa attgttcaat gattggaaaa tcaacctgtc 1440
cagccttgtc caacttagaa agaaactaga actcttcact tatatacaga accagtaatt 1500
aagaagagga aaggtgacat taaatcctat ggtttaggac ctaggtacgg tgggatttat 1560
acatcaaatg ttaaaataat gaattaccac ttgatgacac cagaagacca ccataatctg 1620
atagcaccct atccaaatag agatttagca atagtctcaa caggaggaca tggtgcagaa 1680
acaataccac actgtaactg tacatcaggt gtttactatt ccacatatta cagaaagtat 1740
taccccataa tttgtgaaaa gcccaccaac atctggattg aaggaaaccc ttattaccca 1800
agtagatttc aagcaggagt gatgaaaggg gttgggccag cagaaccagg agactgcggt 1860
gggattttga gatgcataca tggtcccatt ggattgttaa cagctggagg tagtggatat 1920
gtttgttttg ctgacatacg acagttggag tgtatcgcag aggaacaggg gctgagtgat 1980
tacatcacag gtttgggtag agcttttggt gtcgggttca ctgaccaaat ctcaacaaaa 2040
gtcacagaac tacaagaagt ggcgaaagat ttcctcacca caaaagtttt gtccaaagtg 2100
gtcaaaatgg tttcagcttt agtgatcatt tgcagaaatc atgatgactt ggtcactgtt 2160
acggccactc tagcactact tggatgtgat ggatctccct ggagatttct gaagatgtac 2220
atttccaaac actttcaggt gccttacatt gaaagacaag caaatgatgg atggttcaga 2280
aagtttaatg atgcatgtaa tgctgcaaag ggattggaat ggattgctaa taagatttcc 2340
aaactgattg aatggataaa aaacaaagta cttccccaag ccaaagaaaa actagaattt 2400
tgtagtaaac tcaaacaact tgatatacta gagagacaaa taaccaccat gcatatctcg 2460
aatccaacac aggaaaaacg agagcagttg ttcaacaacg tattgtggtt ggaacaaatg 2520
tcgcaaaagt ttgccccaca ttatgccgtt gaatcaaaaa gaatcaggga actcaagaac 2580
aaaatggtaa attatatgca atttaaaagt aaacaaagaa ctgaaccagt gtgtgtatta 2640
atccatggta cacccggttc tggtaaatca ttaacaacat ccattgtggg acgtgcaatt 2700
gcagaacact tcaattcagc agtatattca cttccaccag atcccaagca ctttgatggt 2760
tatcagcaac aggaagttgt gattatggat gatctgaacc aaaatccaga cggacaggat 2820
ataagcatgt tttgtcaaat ggtttcttca gtggatttct tgcctccaat ggctagttta 2880
gataacaagg gcatgttatt caccagtaat tttgttctag cctccacaaa ttctaacaca 2940
ctaagccccc caacaatctt gaatcctgaa gctttagtca ggagatttgg ttttgacctg 3000
gatatatgtt tgcatactac ctacacaaag aatggaaaac tcaatgcagg catgtcaacc 3060
aagacatgca aagattgcca tcaaccatct aatttcaaga aatgttgccc cctggtctgt 3120
ggaaaagcta ttagcttggt agacagaact accaacgtta ggtatagtgt ggatcaactg 3180
gtcacagcta ttataagtga tttcaagagc aaaatgcaaa ttacagattc cctagaaaca 3240
ctgtttcaag gaccagtgta taaagattta gagattgatg tttgcaacac accacctcca 3300
gaatgtatca acgatttact gaaatctgta gattcagaag agattaggga atattgtaag 3360
aagaagaaat ggattatacc tgaaattcct accaacatag aaagagctat gaatcaagcc 3420
agcatgatta ttaatactat tctgatgttt gtcagtacat taggtattgt ttatgtcatt 3480
tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca caataaacta 3540
aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt tgcactatcc 3600
ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac agggttaggc 3660
atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga tgtactagtg 3720
aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga gaacattaat 3780
ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat caggggattt 3840
atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa taactttacc 3900
aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt gagtagcacc 3960
cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg tggaggtgtg 4020
ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag acaaggattt 4080
tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat agctagacat 4140
aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa attacatccc 4200
agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag tgacaatgat 4260
cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg gaatgtaaat 4320
acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca actattatca 4380
ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt agatggacta 4440
gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg gatcaaaaag 4500
agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta tctagacaag 4560
tatggcattg acttgcctct agttacatat attaaggatg aattaagaag tgttgacaaa 4620
gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc tgttaacatg 4680
agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt tctgactgga 4740
tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt aatggatggg 4800
cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt ttggtttgtc 4860
tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat tcaatcaatt 4920
tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg catgccctca 4980
gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat taggactttg 5040
atattagatg catataaagg aatagattta gacaaactta aaatcttagc ttacggtgat 5100
gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac tcttggtaaa 5160
aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa aatgacatgg 5220
gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc ctttttggtt 5280
cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa ggatcctaaa 5340
aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg agaaaaagag 5400
tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct aattctccca 5460
gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa tatagacact 5520
taatttgagt agaagtagga gtttataaaa aaaaaaa 5557
<210> 79
<211> 7148
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 79
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaaca 3180
cttgatgaca ccagaagacc accataatct gatagcaccc tatccaaata gagatttagc 3240
aatagtctca acaggaggac atggtgcaga aacaatacca cactgtaact gtacatcagg 3300
tgtttactat tccacatatt acagaaagta ttaccccata atttgtgaaa agcccaccaa 3360
catctggatt gaaggaaacc cttattaccc aagtagattt caagcaggag tgatgaaagg 3420
ggttgggcca gcagaaccag gagactgcgg tgggattttg agatgcatac atggtcccat 3480
tggattgtta acagctggag gtagtggata tgtttgtttt gctgacatac gacagttgga 3540
gtgtatcgca gaggaacagg ggctgagtga ttacatcaca ggtttgggta gagcttttgg 3600
tgtcgggttc actgaccaaa tctcaacaaa agtcacagaa ctacaagaag tggcgaaaga 3660
tttcctcacc acaaaagttt tgtccaaagt ggtcaaaatg gtttcagctt tagtgatcat 3720
ttgcagaaat catgatgact tggtcactgt tacggccact ctagcactac ttggatgtga 3780
tggatctccc tggagatttc tgaagatgta catttccaaa cactttcagg tgccttacat 3840
tgaaagacaa gcaaatgatg gatggttcag aaagtttaat gatgcatgta atgctgcaaa 3900
gggattggaa tggattgcta ataagatttc caaactgatt gaatggataa aaaacaaagt 3960
acttccccaa gccaaagaaa aactagaatt ttgtagtaaa ctcaaacaac ttgatatact 4020
agagagacaa ataaccacca tgcatatctc gaatccaaca caggaaaaac gagagcagtt 4080
gttcaacaac gtattgtggt tggaacaaat gtcgcaaaag tttgccccac attatgccgt 4140
tgaatcaaaa agaatcaggg aactcaagaa caaaatggta aattatatgc aatttaaaag 4200
taaacaaaga actgaaccag tgtgtgtatt aatccatggt acacccggtt ctggtaaatc 4260
attaacaaca tccattgtgg gacgtgcaat tgcagaacac ttcaattcag cagtatattc 4320
acttccacca gatcccaagc actttgatgg ttatcagcaa caggaagttg tgattatgga 4380
tgatctgaac caaaatccag acggacagga tataagcatg ttttgtcaaa tggtttcttc 4440
agtggatttc ttgcctccaa tggctagttt agataacaag ggcatgttat tcaccagtaa 4500
ttttgttcta gcctccacaa attctaacac actaagcccc ccaacaatct tgaatcctga 4560
agctttagtc aggagatttg gttttgacct ggatatatgt ttgcatacta cctacacaaa 4620
gaatggaaaa ctcaatgcag gcatgtcaac caagacatgc aaagattgcc atcaaccatc 4680
taatttcaag aaatgttgcc ccctggtctg tggaaaagct attagcttgg tagacagaac 4740
taccaacgtt aggtatagtg tggatcaact ggtcacagct attataagtg atttcaagag 4800
caaaatgcaa attacagatt ccctagaaac actgtttcaa ggaccagtgt ataaagattt 4860
agagattgat gtttgcaaca caccacctcc agaatgtatc aacgatttac tgaaatctgt 4920
agattcagaa gagattaggg aatattgtaa gaagaagaaa tggattatac ctgaaattcc 4980
taccaacata gaaagagcta tgaatcaagc cagcatgatt attaatacta ttctgatgtt 5040
tgtcagtaca ttaggtattg tttatgtcat ttataaattg tttgctcaaa ctcaaggacc 5100
atattctggt aacccgcctc acaataaact aaaagcccca actttacgcc cagttgttgt 5160
gcaaggacca aacacagaat ttgcactatc cctgttaagg aaaaacataa tgactataac 5220
aacctcaaag ggagagttca cagggttagg catacatgat cgtgtctgtg tgatacccac 5280
acacgcacag cctggtgatg atgtactagt gaatggtcag aaaattagag ttaaggataa 5340
gtacaaatta gtagatccag agaacattaa tctagagctt acagtgttga ctttagatag 5400
aaatgaaaaa ttcagagata tcaggggatt tatatcagaa gatctagaag gtgtggatgc 5460
cactttggta gtacattcaa ataactttac caacactatc ttagaagttg gccctgtaac 5520
aatggcagga cttattaatt tgagtagcac ccccactaac agaatgattc gttatgatta 5580
tgcaacaaaa actgggcagt gtggaggtgt gctgtgtgct actggtaaga tctttggtat 5640
tcatgttggc ggtaatggaa gacaaggatt ttcagctcaa cttaaaaaac aatattttgt 5700
agagaaacaa ggccaagtaa tagctagaca taaggttagg gagtttaaca taaatccagt 5760
caacacgcca accaagtcaa aattacatcc cagtgtattc tatgatgttt tcccaggtga 5820
caaggaacct gctgtattga gtgacaatga tcccagactg gaagttaaat tgactgaatc 5880
attattctct aagtacaagg ggaatgtaaa tacggaaccc actgaaaata tgcttgtggc 5940
tgtagaccat tatgcagggc aactattatc actagatatc cccacttctg aacttacact 6000
aaaagaagca ttatatggag tagatggact agaacctata gatattacaa ccagtgcagg 6060
atttccctat gtgagtcttg ggatcaaaaa gagagacatt ctgaataaag agacccagga 6120
cacagaaaag atgaagtttt atctagacaa gtatggcatt gacttgcctc tagttacata 6180
tattaaggat gaattaagaa gtgttgacaa agtccgatta gggaaaagta gattaattga 6240
agcctccagt ttgaatgatt ctgttaacat gagaatgaaa ctaggcaacc tttacaaagc 6300
attccatcaa aatcccggtg ttctgactgg atcagcagtg ggttgtgatc ctgatgtgtt 6360
ttggtctgtc atcccttgct taatggatgg gcacctgatg gcatttgatt actctaattt 6420
tgatgcctct ttgtcaccag tttggtttgt ctgtctagag aaggttttga ccaagttagg 6480
ctttgcaggc tcttcattaa ttcaatcaat ttgtaatacc catcatatct ttagggatga 6540
aatatatgtg gttgaaggtg gcatgccctc agggtgttca ggaaccagca tattcaattc 6600
catgatcaac aacataatca ttaggacttt gatattagat gcatataaag gaatagattt 6660
agacaaactt aaaatcttag cttacggtga tgatttgatt gtttcttatc cttatgaact 6720
ggatccgcaa gtgttggcaa ctcttggtaa aaattatgga ctaaccatca cacccccaga 6780
caaatctgaa acttttacaa aaatgacatg ggaaaacttg acatttttaa agagatactt 6840
caagcctgat caacaatttc cctttttggt tcacccagtt atgcccatga aagatataca 6900
tgagtcaatc agatggacaa aggatcctaa aaacacacag gatcacgtcc gatcattatg 6960
catgttagca tggcactcag gagaaaaaga gtacaatgaa ttcattcaga agatcagaac 7020
tactgacatt ggaaaatgtc taattctccc agaatacagc gtacttagga ggcgctggtt 7080
ggacctcttt taggttaaca atatagacac ttaatttgag tagaagtagg agtttataaa 7140
aaaaaaaa 7148
<210> 80
<211> 7171
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 80
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat taccagactg cggtgggatt 3480
ttgagatgca tacatggtcc cattggattg ttaacagctg gaggtagtgg atatgtttgt 3540
tttgctgaca tacgacagtt ggagtgtatc gcagaggaac aggggctgag tgattacatc 3600
acaggtttgg gtagagcttt tggtgtcggg ttcactgacc aaatctcaac aaaagtcaca 3660
gaactacaag aagtggcgaa agatttcctc accacaaaag ttttgtccaa agtggtcaaa 3720
atggtttcag ctttagtgat catttgcaga aatcatgatg acttggtcac tgttacggcc 3780
actctagcac tacttggatg tgatggatct ccctggagat ttctgaagat gtacatttcc 3840
aaacactttc aggtgcctta cattgaaaga caagcaaatg atggatggtt cagaaagttt 3900
aatgatgcat gtaatgctgc aaagggattg gaatggattg ctaataagat ttccaaactg 3960
attgaatgga taaaaaacaa agtacttccc caagccaaag aaaaactaga attttgtagt 4020
aaactcaaac aacttgatat actagagaga caaataacca ccatgcatat ctcgaatcca 4080
acacaggaaa aacgagagca gttgttcaac aacgtattgt ggttggaaca aatgtcgcaa 4140
aagtttgccc cacattatgc cgttgaatca aaaagaatca gggaactcaa gaacaaaatg 4200
gtaaattata tgcaatttaa aagtaaacaa agaactgaac cagtgtgtgt attaatccat 4260
ggtacacccg gttctggtaa atcattaaca acatccattg tgggacgtgc aattgcagaa 4320
cacttcaatt cagcagtata ttcacttcca ccagatccca agcactttga tggttatcag 4380
caacaggaag ttgtgattat ggatgatctg aaccaaaatc cagacggaca ggatataagc 4440
atgttttgtc aaatggtttc ttcagtggat ttcttgcctc caatggctag tttagataac 4500
aagggcatgt tattcaccag taattttgtt ctagcctcca caaattctaa cacactaagc 4560
cccccaacaa tcttgaatcc tgaagcttta gtcaggagat ttggttttga cctggatata 4620
tgtttgcata ctacctacac aaagaatgga aaactcaatg caggcatgtc aaccaagaca 4680
tgcaaagatt gccatcaacc atctaatttc aagaaatgtt gccccctggt ctgtggaaaa 4740
gctattagct tggtagacag aactaccaac gttaggtata gtgtggatca actggtcaca 4800
gctattataa gtgatttcaa gagcaaaatg caaattacag attccctaga aacactgttt 4860
caaggaccag tgtataaaga tttagagatt gatgtttgca acacaccacc tccagaatgt 4920
atcaacgatt tactgaaatc tgtagattca gaagagatta gggaatattg taagaagaag 4980
aaatggatta tacctgaaat tcctaccaac atagaaagag ctatgaatca agccagcatg 5040
attattaata ctattctgat gtttgtcagt acattaggta ttgtttatgt catttataaa 5100
ttgtttgctc aaactcaagg accatattct ggtaacccgc ctcacaataa actaaaagcc 5160
ccaactttac gcccagttgt tgtgcaagga ccaaacacag aatttgcact atccctgtta 5220
aggaaaaaca taatgactat aacaacctca aagggagagt tcacagggtt aggcatacat 5280
gatcgtgtct gtgtgatacc cacacacgca cagcctggtg atgatgtact agtgaatggt 5340
cagaaaatta gagttaagga taagtacaaa ttagtagatc cagagaacat taatctagag 5400
cttacagtgt tgactttaga tagaaatgaa aaattcagag atatcagggg atttatatca 5460
gaagatctag aaggtgtgga tgccactttg gtagtacatt caaataactt taccaacact 5520
atcttagaag ttggccctgt aacaatggca ggacttatta atttgagtag cacccccact 5580
aacagaatga ttcgttatga ttatgcaaca aaaactgggc agtgtggagg tgtgctgtgt 5640
gctactggta agatctttgg tattcatgtt ggcggtaatg gaagacaagg attttcagct 5700
caacttaaaa aacaatattt tgtagagaaa caaggccaag taatagctag acataaggtt 5760
agggagttta acataaatcc agtcaacacg ccaaccaagt caaaattaca tcccagtgta 5820
ttctatgatg ttttcccagg tgacaaggaa cctgctgtat tgagtgacaa tgatcccaga 5880
ctggaagtta aattgactga atcattattc tctaagtaca aggggaatgt aaatacggaa 5940
cccactgaaa atatgcttgt ggctgtagac cattatgcag ggcaactatt atcactagat 6000
atccccactt ctgaacttac actaaaagaa gcattatatg gagtagatgg actagaacct 6060
atagatatta caaccagtgc aggatttccc tatgtgagtc ttgggatcaa aaagagagac 6120
attctgaata aagagaccca ggacacagaa aagatgaagt tttatctaga caagtatggc 6180
attgacttgc ctctagttac atatattaag gatgaattaa gaagtgttga caaagtccga 6240
ttagggaaaa gtagattaat tgaagcctcc agtttgaatg attctgttaa catgagaatg 6300
aaactaggca acctttacaa agcattccat caaaatcccg gtgttctgac tggatcagca 6360
gtgggttgtg atcctgatgt gttttggtct gtcatccctt gcttaatgga tgggcacctg 6420
atggcatttg attactctaa ttttgatgcc tctttgtcac cagtttggtt tgtctgtcta 6480
gagaaggttt tgaccaagtt aggctttgca ggctcttcat taattcaatc aatttgtaat 6540
acccatcata tctttaggga tgaaatatat gtggttgaag gtggcatgcc ctcagggtgt 6600
tcaggaacca gcatattcaa ttccatgatc aacaacataa tcattaggac tttgatatta 6660
gatgcatata aaggaataga tttagacaaa cttaaaatct tagcttacgg tgatgatttg 6720
attgtttctt atccttatga actggatccg caagtgttgg caactcttgg taaaaattat 6780
ggactaacca tcacaccccc agacaaatct gaaactttta caaaaatgac atgggaaaac 6840
ttgacatttt taaagagata cttcaagcct gatcaacaat ttcccttttt ggttcaccca 6900
gttatgccca tgaaagatat acatgagtca atcagatgga caaaggatcc taaaaacaca 6960
caggatcacg tccgatcatt atgcatgtta gcatggcact caggagaaaa agagtacaat 7020
gaattcattc agaagatcag aactactgac attggaaaat gtctaattct cccagaatac 7080
agcgtactta ggaggcgctg gttggacctc ttttaggtta acaatataga cacttaattt 7140
gagtagaagt aggagtttat aaaaaaaaaa a 7171
<210> 81
<211> 7165
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 81
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga agatttctga agatgtacat ttccaaacac 3840
tttcaggtgc cttacattga aagacaagca aatgatggat ggttcagaaa gtttaatgat 3900
gcatgtaatg ctgcaaaggg attggaatgg attgctaata agatttccaa actgattgaa 3960
tggataaaaa acaaagtact tccccaagcc aaagaaaaac tagaattttg tagtaaactc 4020
aaacaacttg atatactaga gagacaaata accaccatgc atatctcgaa tccaacacag 4080
gaaaaacgag agcagttgtt caacaacgta ttgtggttgg aacaaatgtc gcaaaagttt 4140
gccccacatt atgccgttga atcaaaaaga atcagggaac tcaagaacaa aatggtaaat 4200
tatatgcaat ttaaaagtaa acaaagaact gaaccagtgt gtgtattaat ccatggtaca 4260
cccggttctg gtaaatcatt aacaacatcc attgtgggac gtgcaattgc agaacacttc 4320
aattcagcag tatattcact tccaccagat cccaagcact ttgatggtta tcagcaacag 4380
gaagttgtga ttatggatga tctgaaccaa aatccagacg gacaggatat aagcatgttt 4440
tgtcaaatgg tttcttcagt ggatttcttg cctccaatgg ctagtttaga taacaagggc 4500
atgttattca ccagtaattt tgttctagcc tccacaaatt ctaacacact aagcccccca 4560
acaatcttga atcctgaagc tttagtcagg agatttggtt ttgacctgga tatatgtttg 4620
catactacct acacaaagaa tggaaaactc aatgcaggca tgtcaaccaa gacatgcaaa 4680
gattgccatc aaccatctaa tttcaagaaa tgttgccccc tggtctgtgg aaaagctatt 4740
agcttggtag acagaactac caacgttagg tatagtgtgg atcaactggt cacagctatt 4800
ataagtgatt tcaagagcaa aatgcaaatt acagattccc tagaaacact gtttcaagga 4860
ccagtgtata aagatttaga gattgatgtt tgcaacacac cacctccaga atgtatcaac 4920
gatttactga aatctgtaga ttcagaagag attagggaat attgtaagaa gaagaaatgg 4980
attatacctg aaattcctac caacatagaa agagctatga atcaagccag catgattatt 5040
aatactattc tgatgtttgt cagtacatta ggtattgttt atgtcattta taaattgttt 5100
gctcaaactc aaggaccata ttctggtaac ccgcctcaca ataaactaaa agccccaact 5160
ttacgcccag ttgttgtgca aggaccaaac acagaatttg cactatccct gttaaggaaa 5220
aacataatga ctataacaac ctcaaaggga gagttcacag ggttaggcat acatgatcgt 5280
gtctgtgtga tacccacaca cgcacagcct ggtgatgatg tactagtgaa tggtcagaaa 5340
attagagtta aggataagta caaattagta gatccagaga acattaatct agagcttaca 5400
gtgttgactt tagatagaaa tgaaaaattc agagatatca ggggatttat atcagaagat 5460
ctagaaggtg tggatgccac tttggtagta cattcaaata actttaccaa cactatctta 5520
gaagttggcc ctgtaacaat ggcaggactt attaatttga gtagcacccc cactaacaga 5580
atgattcgtt atgattatgc aacaaaaact gggcagtgtg gaggtgtgct gtgtgctact 5640
ggtaagatct ttggtattca tgttggcggt aatggaagac aaggattttc agctcaactt 5700
aaaaaacaat attttgtaga gaaacaaggc caagtaatag ctagacataa ggttagggag 5760
tttaacataa atccagtcaa cacgccaacc aagtcaaaat tacatcccag tgtattctat 5820
gatgttttcc caggtgacaa ggaacctgct gtattgagtg acaatgatcc cagactggaa 5880
gttaaattga ctgaatcatt attctctaag tacaagggga atgtaaatac ggaacccact 5940
gaaaatatgc ttgtggctgt agaccattat gcagggcaac tattatcact agatatcccc 6000
acttctgaac ttacactaaa agaagcatta tatggagtag atggactaga acctatagat 6060
attacaacca gtgcaggatt tccctatgtg agtcttggga tcaaaaagag agacattctg 6120
aataaagaga cccaggacac agaaaagatg aagttttatc tagacaagta tggcattgac 6180
ttgcctctag ttacatatat taaggatgaa ttaagaagtg ttgacaaagt ccgattaggg 6240
aaaagtagat taattgaagc ctccagtttg aatgattctg ttaacatgag aatgaaacta 6300
ggcaaccttt acaaagcatt ccatcaaaat cccggtgttc tgactggatc agcagtgggt 6360
tgtgatcctg atgtgttttg gtctgtcatc ccttgcttaa tggatgggca cctgatggca 6420
tttgattact ctaattttga tgcctctttg tcaccagttt ggtttgtctg tctagagaag 6480
gttttgacca agttaggctt tgcaggctct tcattaattc aatcaatttg taatacccat 6540
catatcttta gggatgaaat atatgtggtt gaaggtggca tgccctcagg gtgttcagga 6600
accagcatat tcaattccat gatcaacaac ataatcatta ggactttgat attagatgca 6660
tataaaggaa tagatttaga caaacttaaa atcttagctt acggtgatga tttgattgtt 6720
tcttatcctt atgaactgga tccgcaagtg ttggcaactc ttggtaaaaa ttatggacta 6780
accatcacac ccccagacaa atctgaaact tttacaaaaa tgacatggga aaacttgaca 6840
tttttaaaga gatacttcaa gcctgatcaa caatttccct ttttggttca cccagttatg 6900
cccatgaaag atatacatga gtcaatcaga tggacaaagg atcctaaaaa cacacaggat 6960
cacgtccgat cattatgcat gttagcatgg cactcaggag aaaaagagta caatgaattc 7020
attcagaaga tcagaactac tgacattgga aaatgtctaa ttctcccaga atacagcgta 7080
cttaggaggc gctggttgga cctcttttag gttaacaata tagacactta atttgagtag 7140
aagtaggagt ttataaaaaa aaaaa 7165
<210> 82
<211> 7181
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 82
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttctggattg ctaataagat 3960
ttccaaactg attgaatgga taaaaaacaa agtacttccc caagccaaag aaaaactaga 4020
attttgtagt aaactcaaac aacttgatat actagagaga caaataacca ccatgcatat 4080
ctcgaatcca acacaggaaa aacgagagca gttgttcaac aacgtattgt ggttggaaca 4140
aatgtcgcaa aagtttgccc cacattatgc cgttgaatca aaaagaatca gggaactcaa 4200
gaacaaaatg gtaaattata tgcaatttaa aagtaaacaa agaactgaac cagtgtgtgt 4260
attaatccat ggtacacccg gttctggtaa atcattaaca acatccattg tgggacgtgc 4320
aattgcagaa cacttcaatt cagcagtata ttcacttcca ccagatccca agcactttga 4380
tggttatcag caacaggaag ttgtgattat ggatgatctg aaccaaaatc cagacggaca 4440
ggatataagc atgttttgtc aaatggtttc ttcagtggat ttcttgcctc caatggctag 4500
tttagataac aagggcatgt tattcaccag taattttgtt ctagcctcca caaattctaa 4560
cacactaagc cccccaacaa tcttgaatcc tgaagcttta gtcaggagat ttggttttga 4620
cctggatata tgtttgcata ctacctacac aaagaatgga aaactcaatg caggcatgtc 4680
aaccaagaca tgcaaagatt gccatcaacc atctaatttc aagaaatgtt gccccctggt 4740
ctgtggaaaa gctattagct tggtagacag aactaccaac gttaggtata gtgtggatca 4800
actggtcaca gctattataa gtgatttcaa gagcaaaatg caaattacag attccctaga 4860
aacactgttt caaggaccag tgtataaaga tttagagatt gatgtttgca acacaccacc 4920
tccagaatgt atcaacgatt tactgaaatc tgtagattca gaagagatta gggaatattg 4980
taagaagaag aaatggatta tacctgaaat tcctaccaac atagaaagag ctatgaatca 5040
agccagcatg attattaata ctattctgat gtttgtcagt acattaggta ttgtttatgt 5100
catttataaa ttgtttgctc aaactcaagg accatattct ggtaacccgc ctcacaataa 5160
actaaaagcc ccaactttac gcccagttgt tgtgcaagga ccaaacacag aatttgcact 5220
atccctgtta aggaaaaaca taatgactat aacaacctca aagggagagt tcacagggtt 5280
aggcatacat gatcgtgtct gtgtgatacc cacacacgca cagcctggtg atgatgtact 5340
agtgaatggt cagaaaatta gagttaagga taagtacaaa ttagtagatc cagagaacat 5400
taatctagag cttacagtgt tgactttaga tagaaatgaa aaattcagag atatcagggg 5460
atttatatca gaagatctag aaggtgtgga tgccactttg gtagtacatt caaataactt 5520
taccaacact atcttagaag ttggccctgt aacaatggca ggacttatta atttgagtag 5580
cacccccact aacagaatga ttcgttatga ttatgcaaca aaaactgggc agtgtggagg 5640
tgtgctgtgt gctactggta agatctttgg tattcatgtt ggcggtaatg gaagacaagg 5700
attttcagct caacttaaaa aacaatattt tgtagagaaa caaggccaag taatagctag 5760
acataaggtt agggagttta acataaatcc agtcaacacg ccaaccaagt caaaattaca 5820
tcccagtgta ttctatgatg ttttcccagg tgacaaggaa cctgctgtat tgagtgacaa 5880
tgatcccaga ctggaagtta aattgactga atcattattc tctaagtaca aggggaatgt 5940
aaatacggaa cccactgaaa atatgcttgt ggctgtagac cattatgcag ggcaactatt 6000
atcactagat atccccactt ctgaacttac actaaaagaa gcattatatg gagtagatgg 6060
actagaacct atagatatta caaccagtgc aggatttccc tatgtgagtc ttgggatcaa 6120
aaagagagac attctgaata aagagaccca ggacacagaa aagatgaagt tttatctaga 6180
caagtatggc attgacttgc ctctagttac atatattaag gatgaattaa gaagtgttga 6240
caaagtccga ttagggaaaa gtagattaat tgaagcctcc agtttgaatg attctgttaa 6300
catgagaatg aaactaggca acctttacaa agcattccat caaaatcccg gtgttctgac 6360
tggatcagca gtgggttgtg atcctgatgt gttttggtct gtcatccctt gcttaatgga 6420
tgggcacctg atggcatttg attactctaa ttttgatgcc tctttgtcac cagtttggtt 6480
tgtctgtcta gagaaggttt tgaccaagtt aggctttgca ggctcttcat taattcaatc 6540
aatttgtaat acccatcata tctttaggga tgaaatatat gtggttgaag gtggcatgcc 6600
ctcagggtgt tcaggaacca gcatattcaa ttccatgatc aacaacataa tcattaggac 6660
tttgatatta gatgcatata aaggaataga tttagacaaa cttaaaatct tagcttacgg 6720
tgatgatttg attgtttctt atccttatga actggatccg caagtgttgg caactcttgg 6780
taaaaattat ggactaacca tcacaccccc agacaaatct gaaactttta caaaaatgac 6840
atgggaaaac ttgacatttt taaagagata cttcaagcct gatcaacaat ttcccttttt 6900
ggttcaccca gttatgccca tgaaagatat acatgagtca atcagatgga caaaggatcc 6960
taaaaacaca caggatcacg tccgatcatt atgcatgtta gcatggcact caggagaaaa 7020
agagtacaat gaattcattc agaagatcag aactactgac attggaaaat gtctaattct 7080
cccagaatac agcgtactta ggaggcgctg gttggacctc ttttaggtta acaatataga 7140
cacttaattt gagtagaagt aggagtttat aaaaaaaaaa a 7181
<210> 83
<211> 7187
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 83
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagctat tctgatgttt gtcagtacat taggtattgt 5100
ttatgtcatt tataaattgt ttgctcaaac tcaaggacca tattctggta acccgcctca 5160
caataaacta aaagccccaa ctttacgccc agttgttgtg caaggaccaa acacagaatt 5220
tgcactatcc ctgttaagga aaaacataat gactataaca acctcaaagg gagagttcac 5280
agggttaggc atacatgatc gtgtctgtgt gatacccaca cacgcacagc ctggtgatga 5340
tgtactagtg aatggtcaga aaattagagt taaggataag tacaaattag tagatccaga 5400
gaacattaat ctagagctta cagtgttgac tttagataga aatgaaaaat tcagagatat 5460
caggggattt atatcagaag atctagaagg tgtggatgcc actttggtag tacattcaaa 5520
taactttacc aacactatct tagaagttgg ccctgtaaca atggcaggac ttattaattt 5580
gagtagcacc cccactaaca gaatgattcg ttatgattat gcaacaaaaa ctgggcagtg 5640
tggaggtgtg ctgtgtgcta ctggtaagat ctttggtatt catgttggcg gtaatggaag 5700
acaaggattt tcagctcaac ttaaaaaaca atattttgta gagaaacaag gccaagtaat 5760
agctagacat aaggttaggg agtttaacat aaatccagtc aacacgccaa ccaagtcaaa 5820
attacatccc agtgtattct atgatgtttt cccaggtgac aaggaacctg ctgtattgag 5880
tgacaatgat cccagactgg aagttaaatt gactgaatca ttattctcta agtacaaggg 5940
gaatgtaaat acggaaccca ctgaaaatat gcttgtggct gtagaccatt atgcagggca 6000
actattatca ctagatatcc ccacttctga acttacacta aaagaagcat tatatggagt 6060
agatggacta gaacctatag atattacaac cagtgcagga tttccctatg tgagtcttgg 6120
gatcaaaaag agagacattc tgaataaaga gacccaggac acagaaaaga tgaagtttta 6180
tctagacaag tatggcattg acttgcctct agttacatat attaaggatg aattaagaag 6240
tgttgacaaa gtccgattag ggaaaagtag attaattgaa gcctccagtt tgaatgattc 6300
tgttaacatg agaatgaaac taggcaacct ttacaaagca ttccatcaaa atcccggtgt 6360
tctgactgga tcagcagtgg gttgtgatcc tgatgtgttt tggtctgtca tcccttgctt 6420
aatggatggg cacctgatgg catttgatta ctctaatttt gatgcctctt tgtcaccagt 6480
ttggtttgtc tgtctagaga aggttttgac caagttaggc tttgcaggct cttcattaat 6540
tcaatcaatt tgtaataccc atcatatctt tagggatgaa atatatgtgg ttgaaggtgg 6600
catgccctca gggtgttcag gaaccagcat attcaattcc atgatcaaca acataatcat 6660
taggactttg atattagatg catataaagg aatagattta gacaaactta aaatcttagc 6720
ttacggtgat gatttgattg tttcttatcc ttatgaactg gatccgcaag tgttggcaac 6780
tcttggtaaa aattatggac taaccatcac acccccagac aaatctgaaa cttttacaaa 6840
aatgacatgg gaaaacttga catttttaaa gagatacttc aagcctgatc aacaatttcc 6900
ctttttggtt cacccagtta tgcccatgaa agatatacat gagtcaatca gatggacaaa 6960
ggatcctaaa aacacacagg atcacgtccg atcattatgc atgttagcat ggcactcagg 7020
agaaaaagag tacaatgaat tcattcagaa gatcagaact actgacattg gaaaatgtct 7080
aattctccca gaatacagcg tacttaggag gcgctggttg gacctctttt aggttaacaa 7140
tatagacact taatttgagt agaagtagga gtttataaaa aaaaaaa 7187
<210> 84
<211> 7182
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 84
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagaaag agctatgaat caagccagca tgattattaa 5100
tactattctg atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc 5160
tcaaactcaa ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt 5220
acgcccagtt gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa 5280
cataatgact ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt 5340
ctgtgtgata cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat 5400
tagagttaag gataagtaca atgactttag atagaaatga aaaattcaga gatatcaggg 5460
gatttatatc agaagatcta gaaggtgtgg atgccacttt ggtagtacat tcaaataact 5520
ttaccaacac tatcttagaa gttggccctg taacaatggc aggacttatt aatttgagta 5580
gcacccccac taacagaatg attcgttatg attatgcaac aaaaactggg cagtgtggag 5640
gtgtgctgtg tgctactggt aagatctttg gtattcatgt tggcggtaat ggaagacaag 5700
gattttcagc tcaacttaaa aaacaatatt ttgtagagaa acaaggccaa gtaatagcta 5760
gacataaggt tagggagttt aacataaatc cagtcaacac gccaaccaag tcaaaattac 5820
atcccagtgt attctatgat gttttcccag gtgacaagga acctgctgta ttgagtgaca 5880
atgatcccag actggaagtt aaattgactg aatcattatt ctctaagtac aaggggaatg 5940
taaatacgga acccactgaa aatatgcttg tggctgtaga ccattatgca gggcaactat 6000
tatcactaga tatccccact tctgaactta cactaaaaga agcattatat ggagtagatg 6060
gactagaacc tatagatatt acaaccagtg caggatttcc ctatgtgagt cttgggatca 6120
aaaagagaga cattctgaat aaagagaccc aggacacaga aaagatgaag ttttatctag 6180
acaagtatgg cattgacttg cctctagtta catatattaa ggatgaatta agaagtgttg 6240
acaaagtccg attagggaaa agtagattaa ttgaagcctc cagtttgaat gattctgtta 6300
acatgagaat gaaactaggc aacctttaca aagcattcca tcaaaatccc ggtgttctga 6360
ctggatcagc agtgggttgt gatcctgatg tgttttggtc tgtcatccct tgcttaatgg 6420
atgggcacct gatggcattt gattactcta attttgatgc ctctttgtca ccagtttggt 6480
ttgtctgtct agagaaggtt ttgaccaagt taggctttgc aggctcttca ttaattcaat 6540
caatttgtaa tacccatcat atctttaggg atgaaatata tgtggttgaa ggtggcatgc 6600
cctcagggtg ttcaggaacc agcatattca attccatgat caacaacata atcattagga 6660
ctttgatatt agatgcatat aaaggaatag atttagacaa acttaaaatc ttagcttacg 6720
gtgatgattt gattgtttct tatccttatg aactggatcc gcaagtgttg gcaactcttg 6780
gtaaaaatta tggactaacc atcacacccc cagacaaatc tgaaactttt acaaaaatga 6840
catgggaaaa cttgacattt ttaaagagat acttcaagcc tgatcaacaa tttccctttt 6900
tggttcaccc agttatgccc atgaaagata tacatgagtc aatcagatgg acaaaggatc 6960
ctaaaaacac acaggatcac gtccgatcat tatgcatgtt agcatggcac tcaggagaaa 7020
aagagtacaa tgaattcatt cagaagatca gaactactga cattggaaaa tgtctaattc 7080
tcccagaata cagcgtactt aggaggcgct ggttggacct cttttaggtt aacaatatag 7140
acacttaatt tgagtagaag taggagttta taaaaaaaaa aa 7182
<210> 85
<211> 7176
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 85
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagaaag agctatgaat caagccagca tgattattaa 5100
tactattctg atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc 5160
tcaaactcaa ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt 5220
acgcccagtt gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa 5280
cataatgact ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt 5340
ctgtgtgata cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat 5400
tagagttaag gataagtaca aattagtaga tccagagaac attaatctag agcttacagt 5460
gttgacttta gatagaaatg aaaaattcag agatatcagg ggatttatat cagaagatct 5520
agaaggtgtg gatgccactt tggtagtaca ttcaaataac tttaccaaca ctatcttaga 5580
agttggccct gtaacaatgg caggacttat taatttgagt agcaccccca ctaacagaat 5640
gattcgttat gattatgcaa caaaaactgg gcagtgtgga ggtgtgctgt gtgctactgg 5700
taagatcttt ggtattcatg ttggcggtaa tggaagacaa ggattttcag ctcaacttaa 5760
aaaacaatat tttgtagaga aacaaggcca agtaatagct agacataagg ttagggagtt 5820
taacataaat ccagtcaaca cgccaaccaa gtcaaaatta catcccagtg tattctatga 5880
tgttttccca ggtgacaagg aacctgctgt attgagtgac aatgatccca gactggaagt 5940
taaattgact gaatcattat tctctaagta caaggggaat gtaaatacgg aacccactga 6000
aaatatgctt gtggctgtag accattatgc agggcaacta ttatcactag atatccccac 6060
ttctgaactt acactaaaag aagcattata tggagtagat ggactagaac ctatagatat 6120
tacaacttct gaataaagag acccaggaca cagaaaagat gaagttttat ctagacaagt 6180
atggcattga cttgcctcta gttacatata ttaaggatga attaagaagt gttgacaaag 6240
tccgattagg gaaaagtaga ttaattgaag cctccagttt gaatgattct gttaacatga 6300
gaatgaaact aggcaacctt tacaaagcat tccatcaaaa tcccggtgtt ctgactggat 6360
cagcagtggg ttgtgatcct gatgtgtttt ggtctgtcat cccttgctta atggatgggc 6420
acctgatggc atttgattac tctaattttg atgcctcttt gtcaccagtt tggtttgtct 6480
gtctagagaa ggttttgacc aagttaggct ttgcaggctc ttcattaatt caatcaattt 6540
gtaataccca tcatatcttt agggatgaaa tatatgtggt tgaaggtggc atgccctcag 6600
ggtgttcagg aaccagcata ttcaattcca tgatcaacaa cataatcatt aggactttga 6660
tattagatgc atataaagga atagatttag acaaacttaa aatcttagct tacggtgatg 6720
atttgattgt ttcttatcct tatgaactgg atccgcaagt gttggcaact cttggtaaaa 6780
attatggact aaccatcaca cccccagaca aatctgaaac ttttacaaaa atgacatggg 6840
aaaacttgac atttttaaag agatacttca agcctgatca acaatttccc tttttggttc 6900
acccagttat gcccatgaaa gatatacatg agtcaatcag atggacaaag gatcctaaaa 6960
acacacagga tcacgtccga tcattatgca tgttagcatg gcactcagga gaaaaagagt 7020
acaatgaatt cattcagaag atcagaacta ctgacattgg aaaatgtcta attctcccag 7080
aatacagcgt acttaggagg cgctggttgg acctctttta ggttaacaat atagacactt 7140
aatttgagta gaagtaggag tttataaaaa aaaaaa 7176
<210> 86
<211> 6674
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 86
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcat gggcgctcag gtttctacac agaaaagtgg 660
atctcacgaa aatcaaaaca ttttgaccaa tggatcaaat cagactttca cagttataaa 720
ttactataag gatgcagcaa gtacatcatc agctggtcaa tcactgtcaa tggacccatc 780
taagtttaca gaaccagtta aagatctcat gcttaagggt gcaccagcat tgaattcacc 840
caatgttgag gcctgtggtt atagtgatag agtacaacaa atcacactcg ggaattcaac 900
aataacaaca caagaagcag ccaacgctgt tgtgtgttat gctgaatggc cagagtacct 960
tccagatgtg gacgctagtg atgtcaataa aacttcaaaa ccagacactt ctgtctgtag 1020
gttttacaca ttggatagta agacatggac aacaggttct aaaggctggt gctggaaatt 1080
accagatgca ctcaaagata tgggtgtgtt cgggcaaaac atgtttttcc actcactagg 1140
aagatcaggt tacacagtac acgttcagtg caatgccaca aaattccata gcggttgtct 1200
acttgtagtt gtaataccag aacaccaact ggcttcacat gagggtggca atgtttcagt 1260
taaatacaca ttcacgcatc caggtgaacg tggtatagat ttatcatctg caaatgaagt 1320
gggagggcct gtcaaggatg tcatatacaa tatgaatggt actttattag gaaatctgct 1380
cattttccct caccagttca ttaatctaag aaccaataat acagccacaa tagtgatacc 1440
atacataaac tcagtaccca ttgattcaat gacacgtcac aacaatgtct cactgatggt 1500
catccctatt gcccctctta cagtaccaac tggagcaact ccctcactcc ctataacagt 1560
cacaatagca cctatgtgca ctgagttctc tgggataagg tccaagtcaa ttgtgccaca 1620
aggtttgcca actacaactt tgccggggtc aggacaattc ttgaccacag atgacaggca 1680
atcccccagt gcactgccaa attatgagcc aactccaaga atacacatac cagggaaagt 1740
tcataacttg ctagaaatta tacaggtaga tacactcatt cctatgaaca acacgcatac 1800
aaaagatgag gttaacagtt acctcatacc actaaatgca aacaggcaaa atgagcaggt 1860
ttttgggaca aacctgttta ttggtgatgg ggtcttcaaa actactcttc tgggtgaaat 1920
tgttcagtac tatacacatt ggtctggatc acttagattc tctttgatgt atactggtcc 1980
tgccttgtcc agtgctaaac tcattctagc atacaccccg cctggtgctc gtggtccaca 2040
ggacaggaga gaagcaatgc taggtactca tgttgtctgg gatattggtc tgcaatccac 2100
catagtaatg acaataccat ggacatcagg ggtgcagttt agatatactg atccagatac 2160
atacaccagt gctggctttc tatcatgttg gtatcaaact tctcttatac ttcccccaga 2220
aacgaccggc caggtctact tattatcatt cataagtgca tgtccagatt ttaagcttag 2280
gctgatgaaa gatactcaaa ctatctcaca gactgttgca ctcactgaag gcttaggtga 2340
tgaattagaa gaagtcatcg ttgagaaaac gaaacagacg gtggcctcaa tctcatctgg 2400
tccaaaacac acacaaaaag tccccatact aactgcaaac gaaacagggg ccacaatgcc 2460
tgttcttcca tcagacagca tagaaaccag aactacctac atgcacttta atggttcaga 2520
aactgatgta gaatgctttt tgggtcgtgc agcttgtgtg catgtaactg aaatacaaaa 2580
caaagatgct actggaatag ataatcacag agaagcaaaa ttgttcaatg attggaaaat 2640
caacctgtcc agccttgtcc aacttagaaa gaaactagaa ctcttcactt atgttaggtt 2700
tgattctgag tataccatac tggccactgc atctcaacct gattcagcaa actattcaag 2760
caatttggtg gtccaagcca tgtatgttcc acctggtgcc ccgaatccaa aagagtggga 2820
cgattacaca tggcaaagtg cttcaaaccc cagtgtattc ttcaaggtgg gggatacatc 2880
caggtttagt gtgccttatg taggattggc atcagcatat aattgttttt atgatggtta 2940
ctcacatgat gatgcagaaa ctcagtatgg cataactgtt ctaaaccata tgggtagtat 3000
ggcattcaga atagtaaatg aacatgatga acataaaact cttgtcaaga tcagagttta 3060
tcacagggca aagcacgttg aagcatggat tccaagagca cccagagcac taccctacac 3120
atcaataggg cgcacaaatt atcctaagaa tacagaacca gtaattaaga agaggaaagg 3180
tgacattaaa tcctatggtt taggacctag gtacggtggg atttatacat caaatgttaa 3240
aataatgaat taccacttga tgacaccaga agaccaccat aatctgatag caccctatcc 3300
aaatagagat ttagcaatag tctcaacagg aggacatggt gcagaaacaa taccacactg 3360
taactgtaca tcaggtgttt actattccac atattacaga aagtattacc ccataatttg 3420
tgaaaagccc accaacatct ggattgaagg aaacccttat tacccaagta gatttcaagc 3480
aggagtgatg aaaggggttg ggccagcaga accaggagac tgcggtggga ttttgagatg 3540
catacatggt cccattggat tgttaacagc tggaggtagt ggatatgttt gttttgctga 3600
catacgacag ttggagtgta tcgcagagga acaggggctg agtgattaca tcacaggttt 3660
gggtagagct tttggtgtcg ggttcactga ccaaatctca acaaaagtca cagaactaca 3720
agaagtggcg aaagatttcc tcaccacaaa agttttgtcc aaagtggtca aaatggtttc 3780
agctttagtg atcatttgca gaaatcatga tgacttggtc actgttacgg ccactctagc 3840
actacttgga tgtgatggat ctccctggag atttctgaag atgtacattt ccaaacactt 3900
tcaggtgcct tacattgaaa gacaagcaaa tgatggatgg ttcagaaagt ttaatgatgc 3960
atgtaatgct gcaaagggat tggaatggat tgctaataag atttccaaac tgattgaatg 4020
gataaaaaac aaagtacttc cccaagccaa agaaaaacta gaattttgta gtaaactcaa 4080
acaacttgat atactagaga gacaaataac caccatgcat atctcgaatc caacacagga 4140
aaaacgagag cagttgttca acaacgtatt gtggttggaa caaatgtcgc aaaagtttgc 4200
cccacattat gccgttgaat caaaaagaat cagggaactc aagaacaaaa tggtaaatta 4260
tatgcaattt aaaagtaaac aaagaactga accagtgtgt gtattaatcc atggtacacc 4320
cggttctggt aaatcattaa caacatccat tgtgggacgt gcaattgcag aacacttcaa 4380
ttcagcagta tattcacttc caccagatcc caagcacttt gatggttatc agcaacagga 4440
agttgtgatt atggatgatc tgaaccaaaa tccagacgga caggatataa gcatgttttg 4500
tcaaatggtt tcttcagtgg atttcttgcc tccaatggct agtttagata acaagggcat 4560
gttattcacc agtaattttg ttctagcctc cacaaattct aacacactaa gccccccaac 4620
aatcttgaat cctgaagctt tagtcaggag atttggtttt gacctggata tatgtttgca 4680
tactacctac acaaagaatg gaaaactcaa tgcaggcatg tcaaccaaga catgcaaaga 4740
ttgccatcaa ccatctaatt tcaagaaatg ttgccccctg gtctgtggaa aagctattag 4800
cttggtagac agaactacca acgttaggta tagtgtggat caactggtca cagctattat 4860
aagtgatttc aagagcaaaa tgcaaattac agattcccta gaaacactgt ttcaaggacc 4920
agtgtataaa gatttagaga ttgatgtttg caacacacca cctccagaat gtatcaacga 4980
tttactgaaa tctgtagatt cagaagagat tagggaatat tgtaagaaga agaaatggat 5040
tatacctgaa attcctacca acatagaaag agctatgaat caagccagca tgattattaa 5100
tactattctg atgtttgtca gtacattagg tattgtttat gtcatttata aattgtttgc 5160
tcaaactcaa ggaccatatt ctggtaaccc gcctcacaat aaactaaaag ccccaacttt 5220
acgcccagtt gttgtgcaag gaccaaacac agaatttgca ctatccctgt taaggaaaaa 5280
cataatgact ataacaacct caaagggaga gttcacaggg ttaggcatac atgatcgtgt 5340
ctgtgtgata cccacacacg cacagcctgg tgatgatgta ctagtgaatg gtcagaaaat 5400
tagagttaag gataagtaca aattagtaga tccagagaac attaatctag agcttacagt 5460
gttgacttta gatagaaatg aaaaattcag agatatcagg ggatttatat cagaagatct 5520
agaaggtgtg gatgccactt tggtagtaca ttcaaataac tttaccaaca ctatcttaga 5580
agttggccct gtaacaatgg caggacttat taatttgagt agcaccccca ctaacagaat 5640
gattcgttat gattatgcaa caaaaactgg gcagtgtgga ggtgtgctgt gtgctactgg 5700
taagatcttt ggtattcatg ttggcggtaa tggaagacaa ggattttcag ctcaacttaa 5760
aaaacaatat tttgtagaga aacaaggcca agtaatagct agacataagg ttagggagtt 5820
taacataaat ccagtcaaca cgccaaccaa gtcaaaatta catcccagtg tattctatga 5880
tgttttccca ggtgacaagg aacctgctgt attgagtgac aatgatccca gactggaagt 5940
taaattgact gaatcattat tctctaagta caaggggaat gtaaatacgg aacccactga 6000
aaatatgctt gtggctgtag accattatgc agggcaacta ttatcactag atatccccac 6060
ttctgaactt acactaaaag aagcattata tggagtagat ggactagaac ctatagatat 6120
tacaaccagt gcaggatttc cctatgtgag tcttgggatc aaaaagagag acattctgaa 6180
taaagagacc caggacacag aaaagatgaa gttttatcta gacaagtatg gcattgactt 6240
gcctctagtt acatatatta aggatgaatt aagaagtgtt gacaaagtcc gattagggaa 6300
aagtagatta attgaagcct ccagtttgaa tgattctgtt aacatgagaa tgaaactagg 6360
caacctttac aaagcattcc atcaaaatcc cggtgttctg actggatcag cagtgggttg 6420
tgatcctgat gtgttttggt ctgtaaagga tcctaaaaac acacaggatc acgtccgatc 6480
attatgcatg ttagcatggc actcaggaga aaaagagtac aatgaattca ttcagaagat 6540
cagaactact gacattggaa aatgtctaat tctcccagaa tacagcgtac ttaggaggcg 6600
ctggttggac ctcttttagg ttaacaatat agacacttaa tttgagtaga agtaggagtt 6660
tataaaaaaa aaaa 6674
<210> 87
<211> 1106
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 87
ttaaaacagc ggatgggtat cccaccattc gacccattgg gtgtagtact ctggtactat 60
gtacctttgt acgcctgttt ctccccaacc acccttcctt aaaattccca cccatgaaac 120
gttagaagct tgacattaaa gtacaatagg tggcgccata tccaatggtg tctatgtaca 180
agcacttctg tttccccgga gcgaggtata ggctgtaccc actgccaaaa gcctttaacc 240
gttatccgcc aaccaactac gtaacagtta gtaccatctt gttcttgact ggacgttcga 300
tcaggtggat tttccctcca ctagtttggt cgatgaggct aggaattccc cacgggtgac 360
cgtgtcctag cctgcgtggc ggccaaccca gcttatgctg ggacgccctt ttaaggacat 420
ggtgtgaaga ctcgcatgtg cttggttgtg agtcctccgg cccctgaatg cggctaacct 480
taaccctgga gccttatgcc acgatccagt ggttgtaagg tcgtaatgag caattccggg 540
acgggaccga ctactttggg tgtccgtgtt tctcattttt cttcatattg tcttatggtc 600
acagcatata tatacatata ctgtgatcaa gcttaggctg atgaaagata ctcaaactat 660
ctcacagact gttgcactca ctgaaggctt aggtgatgaa ttagaagaag tcatcgttga 720
gaaaacgaaa cagacggtgg cctcaatctc atctggtcca aaacacacac aaaaagtccc 780
catactaact gcaaacgaaa caggggccac aatgcctgtt cttccatcag acagcataga 840
aaccagaact acctacatgc actttaatgg ttcagaaact gatgtagaat gctttttggg 900
tcgtgcagct tgtgtgcatg taactgaaat acaaaacaaa gatgctactg gaatagataa 960
tcacagagaa gcaaaattgt tcaatgattg gaaaatcaac ctgtccagcc ttgtccaact 1020
tagaaagaaa ctagaactct tcacttatta ggttaacaat atagacactt aatttgagta 1080
gaagtaggag tttataaaaa aaaaaa 1106
<210> 88
<211> 7140
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 88
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaagggttc 2880
agacaacaat gaatatggaa ttgctcccac caatgacatg ggtttgttat gcttcaggac 2940
tttggacaat agtggtggaa atgatgtgaa aatatacgtc aaacccaaac acataacggc 3000
atgggtacca agaccaccaa gggcaacaca gtacacccac aagtacagta caaactacca 3060
ttacaaacct aactctagtg gacctgatga acacgtgctt aaagacagac actttatcaa 3120
aaccagaccc ctcatcagct cagcgggacc gagcgacatg tttgtgcaca caagagatgc 3180
aatttataaa tgtgcacatc taaccaatcc aactgatgaa accatacttc tggcattgac 3240
tgcagatcta caggtggata gtaccaatgt tccaggcccc gatgtgattc cgtgttgtga 3300
ttgcactgct ggttgctact actctagaag caaagacaga tacttcccag tggagtgtgt 3360
tagtcatgac tggtatgaga tacaagaatc tggctactat cccaaacata tacaatataa 3420
tctactcatt ggggaaggac actgtgaacc aggtgactgt ggaggcaagt tactatgcaa 3480
gcatggtgtg attggtatga tcactgcagg tggtgataac catgttgctt tcactgacct 3540
acgcccatac tcaagcttat cagaacacca aggggttatt tcagattact tcacccagtt 3600
gggtaatgca tttggtgagg gcttcacaac caacattcaa gaccactttt cacaaatcac 3660
caagtcaatt tctgacaaat ttacatcaaa ggctattaaa tggttggtgc gcatcataag 3720
cgcccttaca attatgatta gaaacaactc agacttgcct accatacttg ctactctgtc 3780
attgttgggg tgtagtagct caccatggtc tttcctcaag gacaaaatct gcagctggct 3840
tcaaatccag cgtcccgcaa gcaaacagag tgattcatgg ttgcgcaaat tcacagaatg 3900
ttgcaatgca gcaaaaggac ttgaatggat cagtatcaag attggcaagt ttattgattg 3960
gctgaaaggg aaactagtcc ccgctgtcca gaggaaaaga gacaccctag atagatgcaa 4020
gaaaatatct ctcttagaag aacaagtgaa tggattcagt tctgctagct cagaagcaca 4080
acaacaactt attgtagaag tggatactct aaagaagggt ttagatgagc tggcaccatt 4140
gtatgctagt gaaaacaaaa gggtgactaa gattcaaaaa gatctcaaac aactatcagc 4200
ttatctaaag aaccataggc atgaaccagt ttgcttattg ttacatggca acccaggatg 4260
tggaaaatca ctagttacaa ccataatcgc tagaggactc acccaggagg cacaggtata 4320
ctcactacca cctgatccca aatatttcga tggttatgac caacagcagg ttgtcatatt 4380
ggatgatctt ggacaaaatc ctgatggtaa agatttaagc acattctgtc agatggtatc 4440
aacaacagat ttcatagtac ctatggcatc actagaggat aagggtaagt ctttcaccag 4500
ccaatatgtg cttgccagca ctaacctgga cactctgtca ccaccaacag tcacaatacc 4560
tgaggctata aaacggcgat tctttctgga tgccgatctc atcacaacat ctaagttcag 4620
aaataccaca ggactgctag atgtagcaaa ggcactacaa ccatgcacag gttgtcccaa 4680
accagctcac tataaaacgt gctgtcctct gttgtgtggc aaggcagttg tagttcagga 4740
caggaaaaca aaagcaaatt tctcagtgaa cacaatagta gagcagctga ggcatgagaa 4800
tgctaccagg aaaaaggtta aacacaacct tgatgcaata ttccagggtc ttggtgactc 4860
agaaacacca ggttttatag ttgatctgct atcctcatct aaagacccca aagttataga 4920
atattgtgct gaacagggat ggataggtaa agcaaactca accatagaga gggattttaa 4980
ttatgtgcat tacatgttaa attgcttagg tagtctaata attatcttag ggactgtata 5040
tgcactatac aagctgatgt gtatgactca aggaccttac actggcttac caaaccccca 5100
aaccaaaaga ccagagctca ggaaagccac actacagggc cctgagcatg aattcgtcag 5160
ggctttaatt aaaagaaact gccatgtgat aaccacctca aaaggggagt tcaacatgct 5220
tggaatccat gataactgtg cggtggtgcc aacacacgct gaatgtggtg actctgtcac 5280
aattgacggc agggaagtca gggttcttaa acaatgcatt ctcactgaca caaatgacac 5340
agacactgaa ataactctcc tctggttaga tcagaatgaa aaatttaggg acattagaag 5400
gttcatccca gaacaccaac gcgaatggtc aaatatgcat cttgccacaa atgtaactaa 5460
attccccatg ctagatgtgg aggttggcac tgtaatacca tatggagagg tcaacctcag 5520
tggtaaccca acatgtcggc ttctcaagta caactatcct acaaagccag gacaatgtgg 5580
tggtgtcatt gcaaacacag gaaacatagt agcaattcat gttggcggaa atggacgtgt 5640
ggggtatgga gcagcattgc tacgtaagta cttcgcacag tctcaaggtg agatcactgc 5700
caaacatgat gttagagaaa aaggtttgcc acaaattaac acacctaata aaacaaaatt 5760
acaacccagt gtattttatg atgtttttcc aggggtgaag gaaccggcag ccttaagcaa 5820
tggagaccca cggcttgagg ttgatctcag tacatctgtg ttaagtaagt acaaaggtaa 5880
cacacaagtg gaatggaatg ataatatcca gattgcagtt gaccactact cagctcaact 5940
ttacatgtta gacatcaatc ctcaaccatt aaccatggaa caggcagtct atggcataga 6000
gcatctggaa ccactagacc tcaccaccag tgcaggattc ccctatgtaa ctatgggtat 6060
aaagaaaaag gatatagtca acaaagtgac aaaggatgta accaaacttc aggaaatgat 6120
tgacaaatat ggaatagact tgccttatgt cacctatcta aaagatgaat tgagagctcc 6180
tgagaaaatc aagaaaggga aaacgagagc aatagaggca gctagcataa atgacacaac 6240
ccacttccgc atggtgttcg gtaatctctt ttctgtattc catgctaacc caggtgtact 6300
tacaggctct gcagtaggct gtaaccctga tgtgttctgg tctcaaatgt atgcatgtat 6360
ggatggtgag ttgcttgctt ttgattacac aaactatgat ggtagtttgc acccaatctg 6420
gttcaaagca ctaggtaaag tcttagacaa tttgggattc ccaggtcact tagtaaatag 6480
attgtgcaat acaacacaca tctttaaaaa cttgatttat actgtggaag gaggtatgcc 6540
ctctggtatc tgtggcacaa gtattttcaa taccatgatc aataatataa tcattagagt 6600
gttggttctt gaaacataca agaatataga tctggacaag ctaaaaatta tagcatatgg 6660
tgatgatgta gtagtgtcat acccttttga attggatcca atggaaattg ccaataaggc 6720
agtgaggtat gggttaacca tcactccacc agacaagggc agtacatttc ataagattga 6780
ttggacaaat gtcacctttc tcaaaaggca tttcaaacca gacaccaaat acaaatttct 6840
gatacatcca gtatacaaga tggaggacat ctatgaatca attagatgga caaaggaccc 6900
aaagaacaca caagaccatg ttcactcatt gtgtctactt gcatggcaca acggagagga 6960
ggtctatgaa aagtttaggg agaaaatcag atctacaagt gttggtaagg ttctctacac 7020
ccctccttac tcattgttgt acaggcaatg gatagatcaa ttcatataaa caaataatat 7080
aatacaatgt ttgagtagaa cttagtatta taaaaaaaaa aaaaaaaaaa aaaaaaaaaa 7140
<210> 89
<211> 7071
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 89
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaaggacaa 2880
tagtggtgga aatgatgtga aaatatacgt caaacccaaa cacataacgg catgggtacc 2940
aagaccacca agggcaacac agtacaccca caagtacagt acaaactacc attacaaacc 3000
taactctagt ggacctgatg aacacgtgct taaagacaga cactttatca aaaccagacc 3060
cctcatcagc tcagcgggac cgagcgacat gtttgtgcac acaagagatg caatttataa 3120
atgtgcacat ctaaccaatc caactgatga aaccatactt ctggcattga ctgcagatct 3180
acaggtggat agtaccaatg ttccaggccc cgatgtgatt ccgtgttgtg attgcactgc 3240
tggttgctac tactctagaa gcaaagacag atacttccca gtggagtgtg ttagtcatga 3300
ctggtatgag atacaagaat ctggctacta tcccaaacat atacaatata atctactcat 3360
tggggaagga cactgtgaac caggtgactg tggaggcaag ttactatgca agcatggtgt 3420
gattggtatg atcactgcag gtggtgataa ccatgttgct ttcactgacc tacgcccata 3480
ctcaagctta tcagaacacc aaggggttat ttcagattac ttcacccagt tgggtaatgc 3540
atttggtgag ggcttcacaa ccaacattca agaccacttt tcacaaatca ccaagtcaat 3600
ttctgacaaa tttacatcaa aggctattaa atggttggtg cgcatcataa gcgcccttac 3660
aattatgatt agaaacaact cagacttgcc taccatactt gctactctgt cattgttggg 3720
gtgtagtagc tcaccatggt ctttcctcaa ggacaaaatc tgcagctggc ttcaaatcca 3780
gcgtcccgca agcaaacaga gtgattcatg gttgcgcaaa ttcacagaat gttgcaatgc 3840
agcaaaagga cttgaatgga tcagtatcaa gattggcaag tttattgatt ggctgaaagg 3900
gaaactagtc cccgctgtcc agaggaaaag agacacccta gatagatgca agaaaatatc 3960
tctcttagaa gaacaagtga atggattcag ttctgctagc tcagaagcac aacaacaact 4020
tattgtagaa gtggatactc taaagaaggg tttagatgag ctggcaccat tgtatgctag 4080
tgaaaacaaa agggtgacta agattcaaaa agatctcaaa caactatcag cttatctaaa 4140
gaaccatagg catgaaccag tttgcttatt gttacatggc aacccaggat gtggaaaatc 4200
actagttaca accataatcg ctagaggact cacccaggag gcacaggtat actcactacc 4260
acctgatccc aaatatttcg atggttatga ccaacagcag gttgtcatat tggatgatct 4320
tggacaaaat cctgatggta aagatttaag cacattctgt cagatggtat caacaacaga 4380
tttcatagta cctatggcat cactagagga taagggtaag tctttcacca gccaatatgt 4440
gcttgccagc actaacctgg acactctgtc accaccaaca gtcacaatac ctgaggctat 4500
aaaacggcga ttctttctgg atgccgatct catcacaaca tctaagttca gaaataccac 4560
aggactgcta gatgtagcaa aggcactaca accatgcaca ggttgtccca aaccagctca 4620
ctataaaacg tgctgtcctc tgttgtgtgg caaggcagtt gtagttcagg acaggaaaac 4680
aaaagcaaat ttctcagtga acacaatagt agagcagctg aggcatgaga atgctaccag 4740
gaaaaaggtt aaacacaacc ttgatgcaat attccagggt cttggtgact cagaaacacc 4800
aggttttata gttgatctgc tatcctcatc taaagacccc aaagttatag aatattgtgc 4860
tgaacaggga tggataggta aagcaaactc aaccatagag agggatttta attatgtgca 4920
ttacatgtta aattgcttag gtagtctaat aattatctta gggactgtat atgcactata 4980
caagctgatg tgtatgactc aaggacctta cactggctta ccaaaccccc aaaccaaaag 5040
accagagctc aggaaagcca cactacaggg ccctgagcat gaattcgtca gggctttaat 5100
taaaagaaac tgccatgtga taaccacctc aaaaggggag ttcaacatgc ttggaatcca 5160
tgataactgt gcggtggtgc caacacacgc tgaatgtggt gactctgtca caattgacgg 5220
cagggaagtc agggttctta aacaatgcat tctcactgac acaaatgaca cagacactga 5280
aataactctc ctctggttag atcagaatga aaaatttagg gacattagaa ggttcatccc 5340
agaacaccaa cgcgaatggt caaatatgca tcttgccaca aatgtaacta aattccccat 5400
gctagatgtg gaggttggca ctgtaatacc atatggagag gtcaacctca gtggtaaccc 5460
aacatgtcgg cttctcaagt acaactatcc tacaaagcca ggacaatgtg gtggtgtcat 5520
tgcaaacaca ggaaacatag tagcaattca tgttggcgga aatggacgtg tggggtatgg 5580
agcagcattg ctacgtaagt acttcgcaca gtctcaaggt gagatcactg ccaaacatga 5640
tgttagagaa aaaggtttgc cacaaattaa cacacctaat aaaacaaaat tacaacccag 5700
tgtattttat gatgtttttc caggggtgaa ggaaccggca gccttaagca atggagaccc 5760
acggcttgag gttgatctca gtacatctgt gttaagtaag tacaaaggta acacacaagt 5820
ggaatggaat gataatatcc agattgcagt tgaccactac tcagctcaac tttacatgtt 5880
agacatcaat cctcaaccat taaccatgga acaggcagtc tatggcatag agcatctgga 5940
accactagac ctcaccacca gtgcaggatt cccctatgta actatgggta taaagaaaaa 6000
ggatatagtc aacaaagtga caaaggatgt aaccaaactt caggaaatga ttgacaaata 6060
tggaatagac ttgccttatg tcacctatct aaaagatgaa ttgagagctc ctgagaaaat 6120
caagaaaggg aaaacgagag caatagaggc agctagcata aatgacacaa cccacttccg 6180
catggtgttc ggtaatctct tttctgtatt ccatgctaac ccaggtgtac ttacaggctc 6240
tgcagtaggc tgtaaccctg atgtgttctg gtctcaaatg tatgcatgta tggatggtga 6300
gttgcttgct tttgattaca caaactatga tggtagtttg cacccaatct ggttcaaagc 6360
actaggtaaa gtcttagaca atttgggatt cccaggtcac ttagtaaata gattgtgcaa 6420
tacaacacac atctttaaaa acttgattta tactgtggaa ggaggtatgc cctctggtat 6480
ctgtggcaca agtattttca ataccatgat caataatata atcattagag tgttggttct 6540
tgaaacatac aagaatatag atctggacaa gctaaaaatt atagcatatg gtgatgatgt 6600
agtagtgtca tacccttttg aattggatcc aatggaaatt gccaataagg cagtgaggta 6660
tgggttaacc atcactccac cagacaaggg cagtacattt cataagattg attggacaaa 6720
tgtcaccttt ctcaaaaggc atttcaaacc agacaccaaa tacaaatttc tgatacatcc 6780
agtatacaag atggaggaca tctatgaatc aattagatgg acaaaggacc caaagaacac 6840
acaagaccat gttcactcat tgtgtctact tgcatggcac aacggagagg aggtctatga 6900
aaagtttagg gagaaaatca gatctacaag tgttggtaag gttctctaca cccctcctta 6960
ctcattgttg tacaggcaat ggatagatca attcatataa acaaataata taatacaatg 7020
tttgagtaga acttagtatt ataaaaaaaa aaaaaaaaaa aaaaaaaaaa a 7071
<210> 90
<211> 7070
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 90
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaagacaat 2880
agtggtggaa atgatgtgaa aatatacgtc aaacccaaac acataacggc atgggtacca 2940
agaccaccaa gggcaacaca gtacacccac aagtacagta caaactacca ttacaaacct 3000
aactctagtg gacctgatga acacgtgctt aaagacagac actttatcaa aaccagaccc 3060
ctcatcagct cagcgggacc gagcgacatg tttgtgcaca caagagatgc aatttataaa 3120
tgtgcacatc taaccaatcc aactgatgaa accatacttc tggcattgac tgcagatcta 3180
caggtggata gtaccaatgt tccaggcccc gatgtgattc cgtgttgtga ttgcactgct 3240
ggttgctact actctagaag caaagacaga tacttcccag tggagtgtgt tagtcatgac 3300
tggtatgaga tacaagaatc tggctactat cccaaacata tacaatataa tctactcatt 3360
ggggaaggac actgtgaacc aggtgactgt ggaggcaagt tactatgcaa gcatggtgtg 3420
attggtatga tcactgcagg tggtgataac catgttgctt tcactgacct acgcccatac 3480
tcaagcttat cagaacacca aggggttatt tcagattact tcacccagtt gggtaatgca 3540
tttggtgagg gcttcacaac caacattcaa gaccactttt cacaaatcac caagtcaatt 3600
tctgacaaat ttacatcaaa ggctattaaa tggttggtgc gcatcataag cgcccttaca 3660
attatgatta gaaacaactc agacttgcct accatacttg ctactctgtc attgttgggg 3720
tgtagtagct caccatggtc tttcctcaag gacaaaatct gcagctggct tcaaatccag 3780
cgtcccgcaa gcaaacagag tgattcatgg ttgcgcaaat tcacagaatg ttgcaatgca 3840
gcaaaaggac ttgaatggat cagtatcaag attggcaagt ttattgattg gctgaaaggg 3900
aaactagtcc ccgctgtcca gaggaaaaga gacaccctag atagatgcaa gaaaatatct 3960
ctcttagaag aacaagtgaa tggattcagt tctgctagct cagaagcaca acaacaactt 4020
attgtagaag tggatactct aaagaagggt ttagatgagc tggcaccatt gtatgctagt 4080
gaaaacaaaa gggtgactaa gattcaaaaa gatctcaaac aactatcagc ttatctaaag 4140
aaccataggc atgaaccagt ttgcttattg ttacatggca acccaggatg tggaaaatca 4200
ctagttacaa ccataatcgc tagaggactc acccaggagg cacaggtata ctcactacca 4260
cctgatccca aatatttcga tggttatgac caacagcagg ttgtcatatt ggatgatctt 4320
ggacaaaatc ctgatggtaa agatttaagc acattctgtc agatggtatc aacaacagat 4380
ttcatagtac ctatggcatc actagaggat aagggtaagt ctttcaccag ccaatatgtg 4440
cttgccagca ctaacctgga cactctgtca ccaccaacag tcacaatacc tgaggctata 4500
aaacggcgat tctttctgga tgccgatctc atcacaacat ctaagttcag aaataccaca 4560
ggactgctag atgtagcaaa ggcactacaa ccatgcacag gttgtcccaa accagctcac 4620
tataaaacgt gctgtcctct gttgtgtggc aaggcagttg tagttcagga caggaaaaca 4680
aaagcaaatt tctcagtgaa cacaatagta gagcagctga ggcatgagaa tgctaccagg 4740
aaaaaggtta aacacaacct tgatgcaata ttccagggtc ttggtgactc agaaacacca 4800
ggttttatag ttgatctgct atcctcatct aaagacccca aagttataga atattgtgct 4860
gaacagggat ggataggtaa agcaaactca accatagaga gggattttaa ttatgtgcat 4920
tacatgttaa attgcttagg tagtctaata attatcttag ggactgtata tgcactatac 4980
aagctgatgt gtatgactca aggaccttac actggcttac caaaccccca aaccaaaaga 5040
ccagagctca ggaaagccac actacagggc cctgagcatg aattcgtcag ggctttaatt 5100
aaaagaaact gccatgtgat aaccacctca aaaggggagt tcaacatgct tggaatccat 5160
gataactgtg cggtggtgcc aacacacgct gaatgtggtg actctgtcac aattgacggc 5220
agggaagtca gggttcttaa acaatgcatt ctcactgaca caaatgacac agacactgaa 5280
ataactctcc tctggttaga tcagaatgaa aaatttaggg acattagaag gttcatccca 5340
gaacaccaac gcgaatggtc aaatatgcat cttgccacaa atgtaactaa attccccatg 5400
ctagatgtgg aggttggcac tgtaatacca tatggagagg tcaacctcag tggtaaccca 5460
acatgtcggc ttctcaagta caactatcct acaaagccag gacaatgtgg tggtgtcatt 5520
gcaaacacag gaaacatagt agcaattcat gttggcggaa atggacgtgt ggggtatgga 5580
gcagcattgc tacgtaagta cttcgcacag tctcaaggtg agatcactgc caaacatgat 5640
gttagagaaa aaggtttgcc acaaattaac acacctaata aaacaaaatt acaacccagt 5700
gtattttatg atgtttttcc aggggtgaag gaaccggcag ccttaagcaa tggagaccca 5760
cggcttgagg ttgatctcag tacatctgtg ttaagtaagt acaaaggtaa cacacaagtg 5820
gaatggaatg ataatatcca gattgcagtt gaccactact cagctcaact ttacatgtta 5880
gacatcaatc ctcaaccatt aaccatggaa caggcagtct atggcataga gcatctggaa 5940
ccactagacc tcaccaccag tgcaggattc ccctatgtaa ctatgggtat aaagaaaaag 6000
gatatagtca acaaagtgac aaaggatgta accaaacttc aggaaatgat tgacaaatat 6060
ggaatagact tgccttatgt cacctatcta aaagatgaat tgagagctcc tgagaaaatc 6120
aagaaaggga aaacgagagc aatagaggca gctagcataa atgacacaac ccacttccgc 6180
atggtgttcg gtaatctctt ttctgtattc catgctaacc caggtgtact tacaggctct 6240
gcagtaggct gtaaccctga tgtgttctgg tctcaaatgt atgcatgtat ggatggtgag 6300
ttgcttgctt ttgattacac aaactatgat ggtagtttgc acccaatctg gttcaaagca 6360
ctaggtaaag tcttagacaa tttgggattc ccaggtcact tagtaaatag attgtgcaat 6420
acaacacaca tctttaaaaa cttgatttat actgtggaag gaggtatgcc ctctggtatc 6480
tgtggcacaa gtattttcaa taccatgatc aataatataa tcattagagt gttggttctt 6540
gaaacataca agaatataga tctggacaag ctaaaaatta tagcatatgg tgatgatgta 6600
gtagtgtcat acccttttga attggatcca atggaaattg ccaataaggc agtgaggtat 6660
gggttaacca tcactccacc agacaagggc agtacatttc ataagattga ttggacaaat 6720
gtcacctttc tcaaaaggca tttcaaacca gacaccaaat acaaatttct gatacatcca 6780
gtatacaaga tggaggacat ctatgaatca attagatgga caaaggaccc aaagaacaca 6840
caagaccatg ttcactcatt gtgtctactt gcatggcaca acggagagga ggtctatgaa 6900
aagtttaggg agaaaatcag atctacaagt gttggtaagg ttctctacac ccctccttac 6960
tcattgttgt acaggcaatg gatagatcaa ttcatataaa caaataatat aatacaatgt 7020
ttgagtagaa cttagtatta taaaaaaaaa aaaaaaaaaa aaaaaaaaaa 7070
<210> 91
<211> 6945
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 91
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaagggttc 2880
agacaacaat gaatatggaa ttgctcccac caatgacatg ggtttgttat gcttcaggac 2940
tttggacaat agtggtggaa atgatgtgaa aatatacgtc aaacccaaac acataacggc 3000
atgggtacca agaccaccaa gggcaacaca gtacacccac aagtacagta caaactacca 3060
ttacaaacct aactctagtg gacctgatga acacgtgctt aaagacagac actttatcaa 3120
aaccagaccc ctcatcagct cagcgggacc gagcgacatg tttgtgcaca caagagatgc 3180
aatttataaa tgtgcacatc taaccaatcc aactgatgaa accatacttc tggcattgac 3240
tgcagatcta caggtgggtg actgtggagg caagttacta tgcaagcatg gtgtgattgg 3300
tatgatcact gcaggtggtg ataaccatgt tgctttcact gacctacgcc catactcaag 3360
cttatcagaa caccaagggg ttatttcaga ttacttcacc cagttgggta atgcatttgg 3420
tgagggcttc acaaccaaca ttcaagacca cttttcacaa atcaccaagt caatttctga 3480
caaatttaca tcaaaggcta ttaaatggtt ggtgcgcatc ataagcgccc ttacaattat 3540
gattagaaac aactcagact tgcctaccat acttgctact ctgtcattgt tggggtgtag 3600
tagctcacca tggtctttcc tcaaggacaa aatctgcagc tggcttcaaa tccagcgtcc 3660
cgcaagcaaa cagagtgatt catggttgcg caaattcaca gaatgttgca atgcagcaaa 3720
aggacttgaa tggatcagta tcaagattgg caagtttatt gattggctga aagggaaact 3780
agtccccgct gtccagagga aaagagacac cctagataga tgcaagaaaa tatctctctt 3840
agaagaacaa gtgaatggat tcagttctgc tagctcagaa gcacaacaac aacttattgt 3900
agaagtggat actctaaaga agggtttaga tgagctggca ccattgtatg ctagtgaaaa 3960
caaaagggtg actaagattc aaaaagatct caaacaacta tcagcttatc taaagaacca 4020
taggcatgaa ccagtttgct tattgttaca tggcaaccca ggatgtggaa aatcactagt 4080
tacaaccata atcgctagag gactcaccca ggaggcacag gtatactcac taccacctga 4140
tcccaaatat ttcgatggtt atgaccaaca gcaggttgtc atattggatg atcttggaca 4200
aaatcctgat ggtaaagatt taagcacatt ctgtcagatg gtatcaacaa cagatttcat 4260
agtacctatg gcatcactag aggataaggg taagtctttc accagccaat atgtgcttgc 4320
cagcactaac ctggacactc tgtcaccacc aacagtcaca atacctgagg ctataaaacg 4380
gcgattcttt ctggatgccg atctcatcac aacatctaag ttcagaaata ccacaggact 4440
gctagatgta gcaaaggcac tacaaccatg cacaggttgt cccaaaccag ctcactataa 4500
aacgtgctgt cctctgttgt gtggcaaggc agttgtagtt caggacagga aaacaaaagc 4560
aaatttctca gtgaacacaa tagtagagca gctgaggcat gagaatgcta ccaggaaaaa 4620
ggttaaacac aaccttgatg caatattcca gggtcttggt gactcagaaa caccaggttt 4680
tatagttgat ctgctatcct catctaaaga ccccaaagtt atagaatatt gtgctgaaca 4740
gggatggata ggtaaagcaa actcaaccat agagagggat tttaattatg tgcattacat 4800
gttaaattgc ttaggtagtc taataattat cttagggact gtatatgcac tatacaagct 4860
gatgtgtatg actcaaggac cttacactgg cttaccaaac ccccaaacca aaagaccaga 4920
gctcaggaaa gccacactac agggccctga gcatgaattc gtcagggctt taattaaaag 4980
aaactgccat gtgataacca cctcaaaagg ggagttcaac atgcttggaa tccatgataa 5040
ctgtgcggtg gtgccaacac acgctgaatg tggtgactct gtcacaattg acggcaggga 5100
agtcagggtt cttaaacaat gcattctcac tgacacaaat gacacagaca ctgaaataac 5160
tctcctctgg ttagatcaga atgaaaaatt tagggacatt agaaggttca tcccagaaca 5220
ccaacgcgaa tggtcaaata tgcatcttgc cacaaatgta actaaattcc ccatgctaga 5280
tgtggaggtt ggcactgtaa taccatatgg agaggtcaac ctcagtggta acccaacatg 5340
tcggcttctc aagtacaact atcctacaaa gccaggacaa tgtggtggtg tcattgcaaa 5400
cacaggaaac atagtagcaa ttcatgttgg cggaaatgga cgtgtggggt atggagcagc 5460
attgctacgt aagtacttcg cacagtctca aggtgagatc actgccaaac atgatgttag 5520
agaaaaaggt ttgccacaaa ttaacacacc taataaaaca aaattacaac ccagtgtatt 5580
ttatgatgtt tttccagggg tgaaggaacc ggcagcctta agcaatggag acccacggct 5640
tgaggttgat ctcagtacat ctgtgttaag taagtacaaa ggtaacacac aagtggaatg 5700
gaatgataat atccagattg cagttgacca ctactcagct caactttaca tgttagacat 5760
caatcctcaa ccattaacca tggaacaggc agtctatggc atagagcatc tggaaccact 5820
agacctcacc accagtgcag gattccccta tgtaactatg ggtataaaga aaaaggatat 5880
agtcaacaaa gtgacaaagg atgtaaccaa acttcaggaa atgattgaca aatatggaat 5940
agacttgcct tatgtcacct atctaaaaga tgaattgaga gctcctgaga aaatcaagaa 6000
agggaaaacg agagcaatag aggcagctag cataaatgac acaacccact tccgcatggt 6060
gttcggtaat ctcttttctg tattccatgc taacccaggt gtacttacag gctctgcagt 6120
aggctgtaac cctgatgtgt tctggtctca aatgtatgca tgtatggatg gtgagttgct 6180
tgcttttgat tacacaaact atgatggtag tttgcaccca atctggttca aagcactagg 6240
taaagtctta gacaatttgg gattcccagg tcacttagta aatagattgt gcaatacaac 6300
acacatcttt aaaaacttga tttatactgt ggaaggaggt atgccctctg gtatctgtgg 6360
cacaagtatt ttcaatacca tgatcaataa tataatcatt agagtgttgg ttcttgaaac 6420
atacaagaat atagatctgg acaagctaaa aattatagca tatggtgatg atgtagtagt 6480
gtcataccct tttgaattgg atccaatgga aattgccaat aaggcagtga ggtatgggtt 6540
aaccatcact ccaccagaca agggcagtac atttcataag attgattgga caaatgtcac 6600
ctttctcaaa aggcatttca aaccagacac caaatacaaa tttctgatac atccagtata 6660
caagatggag gacatctatg aatcaattag atggacaaag gacccaaaga acacacaaga 6720
ccatgttcac tcattgtgtc tacttgcatg gcacaacgga gaggaggtct atgaaaagtt 6780
tagggagaaa atcagatcta caagtgttgg taaggttctc tacacccctc cttactcatt 6840
gttgtacagg caatggatag atcaattcat ataaacaaat aatataatac aatgtttgag 6900
tagaacttag tattataaaa aaaaaaaaaa aaaaaaaaaa aaaaa 6945
<210> 92
<211> 7088
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 92
ttaaaactgg gtataggttg ttcccacctg taccacccac gtggtgtagt gctcctgtat 60
tccggtacac ttgcacgcca gtttgccctc ccttcctgta acgtagaagc aatgtaaacg 120
gaccaaaagg ggacggcaaa ccacgtcgtt caaggtcaag cacttctgtt tccccggcat 180
gcgaggaata gaccttctca agggttgaag ccacaagtgt cgttacccgc attggtacta 240
cacagagcct agtactgctc tagaaactta ttggttggtc gttcagccat ttcccctggt 300
agacctggca gatgaggcaa gaagttcccc actggtaaca gtgttcttgc ctgcgtggct 360
gcctgcacac cctaacgggt gtgaagccaa tgagtggaca gggtgtgaag agccgcgtgt 420
gctaccaatg agtcctccgg cccctgaatg cggctaatcc aaccccacag ctatggcatg 480
caagccagca tgtgcgtagt cgtaatgagt aattgtggga cggaaccgac tactttgggt 540
gtccgtgttt cctttattct cttatgtttt gcctatggtg acaatattaa gtattaatat 600
tgctaccatg ggcgcccagg tcagtagaca aaacaatggc acacatgaga atggtgtaac 660
agctagcaat ggatcagtca tcaagtattt caacatcaat tactataaag actcagcaag 720
ttctggtttg agtcgtcaag acttttctca ggacccatcc aaatttaccc aaccccttgt 780
ggatacactc acaaacccag cacttatgtc accatctgtt gaagcatgtg gatattctga 840
taggctcaag caaatcacta tcgggaattc cacaatcaca acacaagact ccctacacac 900
agtacttgca tatggtgagt ggcctacata cttatccgac attgatgcaa cgtccgtcga 960
taaacccact cacccagaaa catcagctga tagattttat actctggata gtgttgaatg 1020
gcaagtaggc tctcatggtt ggtggtggaa gctgccagat gccctcaaag acatgggtgt 1080
gtttggccaa aatatgtatt accactcaat gggtagatca ggtttcataa tccatacaca 1140
gtgcaatgca actaaatttc acagtggtgc actcatagtc gcggtgatac cagaacacca 1200
acttgcttat gtgggggggg tgaaggtcaa tgtaggatat gatcatacac acccagggca 1260
aagtggtcat caaatacgtg ggcccagtca atcaaatgac cggagcggtg gcaaaccaga 1320
tgaggaccca ctgtttaatt gcaatggaac attgttaggg aacataacaa ttttcccaca 1380
tcaaattata aatttgagga ccaacaactc cagcacaata gttgtacctt acataaattg 1440
tgtccctatg gacaacatgc taaaacacaa caatctatct ttagtgatta tcccgttggt 1500
accgctacgt ccaggttcta gtggcattaa ttctgtcccg attactgtaa caatagcacc 1560
ctataagtca gaattctcag gtgccatgga ggctcaacgc caaggcttgc caacgcgtct 1620
tcctagtggt agccaacaat tcatgacaac tgaggatgag caatcaccca acattcttcc 1680
tggcttccac ccaagtaaga aaatacacat acctggaatg attacaaacg tgatgcacat 1740
ggccagagta gattcattca tacccattaa taatattcaa ggagaagttg gaaaagtgag 1800
tatgtactat atcacagtga caaaaaagac agtgacagag aggatccttg ttctgcccct 1860
agaaatgagc aacacactat ttgctacaac tcttttaggt gaagttctga actactatgc 1920
caactggtca gggagtatta ccatcacctt tatgtgtgtg tgtgatgcgt tcagcacagg 1980
aaagtttctc gttgcataca caccaccagg aggtaaacta ccagaagaca ggaaacaagc 2040
aatgttaggt gttcacatca tatgggactt gggcctgcag tcgtcctgca ccattgtggt 2100
accatggatt tcatctggtt tctaccgccg caccaaagca gacagtttca cccacggtgg 2160
atatgtctcc ttgtggtacc agacagcttt tgtaccccca gtgagtggag ggacaggaag 2220
tattcttgcc acctgtagtg cttgccccga catgtccgtt aggatgctgc gggatagccc 2280
aatgatggaa caaaagaatg aactgcaaaa caatgatgac ccagttgaga actttgtaga 2340
gtccacccta aaagaggtgt tagttgtgcc agacacaaaa ccctcaggac ctcaacacac 2400
aacaaaaccg tcaatattgg gtgccatgga gattggtgcc tccagtaacg caaccccaga 2460
atccacaata gagactaggt atgtatacaa cacaaataca aatgcagaag cagatgtaga 2520
aatgttccta ggtaggtccg ccctttgggg taaggtaaca ctcacacgcc aatatgccaa 2580
atgggaaata aactttcaag aacaggccca cattaggaaa aaatttgagt tcttcactta 2640
tctgaggttt gacatggagg ttaccatagt aaccaacaac acagggttga tgcaaataat 2700
gttcgttcca ccagggatag accaccctga gacacatgat gacagaaaat gggattccgc 2760
ttccaacccc agtgtatttt tccaacctaa atcaggattt cctaggttta ccatcccatt 2820
tactgggcta gcttcagcat actacatgtt ttatgatgga tatgacaagc ccaagggttc 2880
agacaacaat gaatatggaa ttgctcccac caatgacatg ggtttgttat gcttcaggac 2940
tttggacaat agtggtggaa atgatgtgaa aatatacgtc aaacccaaac acataacggc 3000
atgggtacca agaccaccaa gggcaacaca gtacacccac aagtacagta caaactacca 3060
ttacaaacct aactctagtg gacctgatga acacgtgctt aaagacagac actttatcaa 3120
aaccagaccc ctcatcagct cagcgggacc gagcgacatg tttgtgcaca caagagatgc 3180
aatttataaa tgtgcacatc taaccaatcc aactgatgaa accatacttc tggcattgac 3240
tgcagatcta caggtggata gtaccaatgt tccaggcccc gatgtgattc cgtgttgtga 3300
ttgcactgct ggttgctact actctagaag caaagacaga tacttcccag tggagtgtgt 3360
tagtcatgac tggtatgaga tacaagaatc tggctactat cccaaacata tacaatataa 3420
tctactcatt ggggaaggac actgtgaacc aggtgactgt ggaggcaagt tactatgcaa 3480
gcatggtgtg attggtatga tcactgcagg tggtgataac catgttgctt tcactgacct 3540
acgcccatac tcaagcttat cagaacacca aggggttatt tcagattact tcacccagtt 3600
gggtaatgca tttggtgagg gcttcacaac caacattcaa gaccactttt cacaaatcac 3660
caagtcaatt tctgacaaat ttacatcaaa ggctattaaa tggttggtgc gcatcataag 3720
cgcccttaca attatgatta gaaacaactc agacttgcct accatacttg ctactctgtc 3780
attgttgggg tgtagtagct caccatggtc tttcctcaag gacaaaatct gcagctggct 3840
tcaaatccag cgtcccgcaa gcaaacagag tgattcatgg ttgcgcaaat tcacagaatg 3900
ttgcaatgca gcaaaaggac ttgaatggat cagtatcaag attggcaagt ttattgattg 3960
gctgaaaggg aaactagtcc ccgctgtcca gaggaaaaga gacaccctag atagatgcaa 4020
gaaaatatct ctcttagaag aacaagtgaa tggattcagt tctgctagct cagaagcaca 4080
acaacaactt attgtagaag tggatactct aaagaagggt ttagatgagc tggcaccatt 4140
gtatgctagt gaaaacaaaa gggtgactaa gattcaaaaa gatctcaaac aactatcagc 4200
ttatctaaag aaccataggc atgaaccagt ttgcttattg ttacatggca acccaggatg 4260
tggaaaatca ctagttacaa ccataatcgc tagaggactc acccaggagg cacaggtata 4320
ctcactacca cctgatccca aatatttcga tggttatgac caacagcagg ttgtcatatt 4380
ggatgatctt ggacaaaatc ctgatggtaa agatttaagc acattctgtc agatggtatc 4440
aacaacagat ttcatagtac ctatggcatc actagaggat aagggtaagt ctttcaccag 4500
ccaatatgtg cttgccagca ctaacctgga cactctgtca ccaccaacag tcacaatacc 4560
tgaggctata aaacggcgat tctttctgga tgccgatctc atcacaacat ctaagttcag 4620
aaataccaca ggactgctag atgtagcaaa ggcactacaa ccatgcacag gttgtcccaa 4680
accagctcac tataaaacgt gctgtctttc tcagtgaaca caatagtaga gcagctgagg 4740
catgagaatg ctaccaggaa aaaggttaaa cacaaccttg atgcaatatt ccagggtctt 4800
ggtgactcag aaacaccagg ttttatagtt gatctgctat cctcatctaa agaccccaaa 4860
gttatagaat attgtgctga acagggatgg ataggtaaag caaactcaac catagagagg 4920
gattttaatt atgtgcatta catgttaaat tgcttaggta gtctaataat tatcttaggg 4980
actgtatatg cactatacaa gctgatgtgt atgactcaag gaccttacac tggcttacca 5040
aacccccaaa ccaaaagacc agagctcagg aaagccacac tacagggccc tgagcatgaa 5100
ttcgtcaggg ctttaattaa aagaaactgc catgtgataa ccacctcaaa aggggagttc 5160
aacatgcttg gaatccatga taactgtgcg gtggtgccaa cacacgctga atgtggtgac 5220
tctgtcacaa ttgacggcag ggaagtcagg gttcttaaac aatgcattct cactgacaca 5280
aatgacacag acactgaaat aactctcctc tggttagatc agaatgaaaa atttagggac 5340
attagaaggt tcatcccaga acaccaacgc gaatggtcaa atatgcatct tgccacaaat 5400
gtaactaaat tccccatgct agatgtggag gttggcactg taataccata tggagaggtc 5460
aacctcagtg gtaacccaac atgtcggctt ctcaagtaca actatcctac aaagccagga 5520
caatgtggtg gtgtcattgc aaacacagga aacatagtag caattcatgt tggcggaaat 5580
ggacgtgtgg ggtatggagc agcattgcta cgtaagtact tcgcacagtc tcaaggtgag 5640
atcactgcca aacatgatgt tagagaaaaa ggtttgccac aaattaacac acctaataaa 5700
acaaaattac aacccagtgt attttatgat gtttttccag gggtgaagga accggcagcc 5760
ttaagcaatg gagacccacg gcttgaggtt gatctcagta catctgtgtt aagtaagtac 5820
aaaggtaaca cacaagtgga atggaatgat aatatccaga ttgcagttga ccactactca 5880
gctcaacttt acatgttaga catcaatcct caaccattaa ccatggaaca ggcagtctat 5940
ggcatagagc atctggaacc actagacctc accaccagtg caggattccc ctatgtaact 6000
atgggtataa agaaaaagga tatagtcaac aaagtgacaa aggatgtaac caaacttcag 6060
gaaatgattg acaaatatgg aatagacttg ccttatgtca cctatctaaa agatgaattg 6120
agagctcctg agaaaatcaa gaaagggaaa acgagagcaa tagaggcagc tagcataaat 6180
gacacaaccc acttccgcat ggtgttcggt aatctctttt ctgtattcca tgctaaccca 6240
ggtgtactta caggctctgc agtaggctgt aaccctgatg tgttctggtc tcaaatgtat 6300
gcatgtatgg atggtgagtt gcttgctttt gattacacaa actatgatgg tagtttgcac 6360
ccaatctggt tcaaagcact aggtaaagtc ttagacaatt tgggattccc aggtcactta 6420
gtaaatagat tgtgcaatac aacacacatc tttaaaaact tgatttatac tgtggaagga 6480
ggtatgccct ctggtatctg tggcacaagt attttcaata ccatgatcaa taatataatc 6540
attagagtgt tggttcttga aacatacaag aatatagatc tggacaagct aaaaattata 6600
gcatatggtg atgatgtagt agtgtcatac ccttttgaat tggatccaat ggaaattgcc 6660
aataaggcag tgaggtatgg gttaaccatc actccaccag acaagggcag tacatttcat 6720
aagattgatt ggacaaatgt cacctttctc aaaaggcatt tcaaaccaga caccaaatac 6780
aaatttctga tacatccagt atacaagatg gaggacatct atgaatcaat tagatggaca 6840
aaggacccaa agaacacaca agaccatgtt cactcattgt gtctacttgc atggcacaac 6900
ggagaggagg tctatgaaaa gtttagggag aaaatcagat ctacaagtgt tggtaaggtt 6960
ctctacaccc ctccttactc attgttgtac aggcaatgga tagatcaatt catataaaca 7020
aataatataa tacaatgttt gagtagaact tagtattata aaaaaaaaaa aaaaaaaaaa 7080
aaaaaaaa 7088
<210> 93
<211> 8872
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 93
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagttg gcatcaacac aagaaacatg acaatgtcca tgagcatgat 420
cttggtagga gtgatcatga tgtttttgtc tctaggagtt ggggcggatc aaggatgcgc 480
catcaacttt ggcaagagag agctcaagtg cggagatggt atcttcatat ttagagactc 540
tgatgactgg ctgaacaagt actcatacta tccagaagat cctgtgaagc tggcatcaat 600
agtgaaagcc tcttttgaag aagggaagtg tggcctaaat tcagttgact cccttgagca 660
tgagatgtgg agaagcaggg cagatgagat caatgccatt cttgaggaaa acgaggtgga 720
catttctgtt gtcgtgcagg atccaaagaa tgtttaccag agaggaactc atccattttc 780
cagaattcgg gatggtctgc agtatggttg gaagacttgg ggtaagaacc ttgtgttctc 840
cccagggagg aagaatggaa gcttcatcat agatggaaag tccaggaaag aatgcccgtt 900
ttcaaaccgg gtctggaatt ctttccagat agaggagttt gggacgggag tgttcaccac 960
acgcgtgtac atggacgcag tctttgaata caccatagac tgcgatggat ctatcttggg 1020
tgcagcggtg aacggaaaaa agagtgccca tggctctcca acattttgga tgggaagtca 1080
tgaagtaaat gggacatgga tgatccacac cttggaggca ttagattaca aggagtgtga 1140
gtggccactg acacatacga ttggaacatc agttgaagag agtgaaatgt tcatgccgag 1200
atcaatcgga ggcccagtta gctctcacaa tcatatccct ggatacaagg ttcagacgaa 1260
cggaccttgg atgcaggtac cactagaggt gaagagagaa gcttgcccag ggactagcgt 1320
gatcattgat ggcaactgtg atggacgggg aaaatcaacc agatccacca cggatagcgg 1380
gaaaattatt cctgaatggt gttgccgctc ctgcacaatg ccgcctgtga gcttccatgg 1440
tagtgatggg tgttggtatc ccatggaaat taggccaagg aaaacgcatg aaagccatct 1500
ggtgcgctcc tgggttacag ctggagaaat acatgctgtc ccttttggtt tggtgagcat 1560
gatgatagca atggaagtgg tcctaaggaa aagacaggga ccaaagcaaa tgttggttgg 1620
aggagtggtg ctcttgggag caatgctggt cgggcaagta actctccttg atttgctgaa 1680
actcacagtg gctgtgggat tgcatttcca tgagatgaac aatggaggag acgccatgta 1740
tatggcgttg attgctgcct tttcaatcag accagggctg ctcatcggct ttgggctcag 1800
gaccctatgg agccctcggg aacgccttgt gctgacccta ggagcagcca tggtggagat 1860
tgccttgggt ggcatgatgg gcggcctgtg gaagtatcta aatgcagttt ctctctgcat 1920
cctgacaata aatgctgttg cttctaggaa agcatcaaat accatcttgc ccctcatggc 1980
tctgttgaca cctgtcacta tggctgaggt gagacttgcc acaatgctct tttgtaccgt 2040
ggttatcata ggggtccttc accagaactc caaggacacc tccatgcaga agactatacc 2100
tctggtggcc ctcacactca catcttacct gggcttgaca caaccttttt tgggcctgtg 2160
tgcatttctg gcaacccgca tatttgggcg aaggagtatc ccagtgaatg aggcactcgc 2220
agcagctggt ctagtgggag tgctggcagg actggctttt caggagatgg agaacttcct 2280
tggtccgatt gcagttggag gaatcctgat gatgctggtt agcgtggctg ggagggtgga 2340
tgggctagag ctcaagaagc ttggtgaagt ttcatgggaa gaggaggcgg agatcagcgg 2400
aagttccgcc cgctatgatg tggcactcag tgaacaaggg gagttcaagc tgctttctga 2460
agagaaagtg ccatgggacc aggttgtgat gacctcgctg gccttggttg gggctgccat 2520
tcatccattt gctcttctgc tggtccttgc tgggtggctg tttcatgtca ggggagctag 2580
gagaagtggg gatgtcttgt gggatattcc cactcctaag atcattgagg aatgtgaaca 2640
tctggaggat gggatttatg gcatattcca gtcaaccttc ttgggggcct cccagcgagg 2700
agtgggagtg gcacagggag gggtgttcca cacaatgtgg catgtcacaa gaggagcttt 2760
ccttgtcagg aatggcaaga agttgattcc atcttgggct tcagtaaagg aagaccttgt 2820
cgcctatggt ggctcatgga agttggaagg cagatgggat ggagaggaag aggtccaatt 2880
gatcgctgct gttccaggaa agaacgtggt caacgtccag acaaaaccga gcttgttcaa 2940
agtgaggaat gggggagaaa tcggggctgt cgctcttgac tatccgagtg gcacttcagg 3000
atctcctatt gttaacagga acggagaggt gattgggctg tacggcaatg gcatccttgt 3060
cggtgacaac tccttcgtgt ccgccatatc ccagactgag gtgaaggaag aaggaaagga 3120
ggagctccaa gagatcccga caatgctaaa gaaaggaatg acaactatcc ttgattttca 3180
tcctggagct gggaagacaa gacgttttct cccacagatc ttggccgagt gcgcacggag 3240
acgcttgcgc actcttgtgt tggcccccac cagggttgtt ctttctgaaa tgaaggaggc 3300
ttttcacggc ctggacgtga aattccacac acaggctttt tccgctcacg gcagcgggag 3360
agaagtcatt gatgccatgt gccatgccac cctaacttac aggatgttgg aaccaactag 3420
ggttgttaac tgggaagtga tcatcatgga tgaagcccat tttttggatc cagctagcat 3480
agccgccaga ggttgggcag cgcacagagc tagggcaaat gaaagtgcaa caatcttgat 3540
gacagccaca ccgcctggga ctagtgatga atttccacat tcaaatggtg aaatagaaga 3600
tgttcaaacg gacataccca gtgagccctg gaacacaggg catgactgga tcctggctga 3660
caaaaggccc acggcatggt tccttccatc catcagagct gcaaatgtca tggctgcctc 3720
tttgcgtaag gctggaaaga gtgtggtggt cctgaacagg aaaacctttg agagagaata 3780
ccccacgata aagcagaaga aacctgactt tatattggcc actgacatag ctgaaatggg 3840
agccaacctt tgcgtggagc gagtgctgga ttgcaggacg gcttttaagc ctgtgcttgt 3900
ggatgaaggg aggaaggtgg caataaaagg gccacttcgc atctccgcat cctctgctgc 3960
tcaaaggagg gggcgcattg ggagaaatcc caacagagat ggagactcat actactattc 4020
tgagcccaca agtgaagata atgcccacca cgtctgctgg ttggaggcct caatgctctt 4080
ggacaacatg gaggtgaggg gtggaatggt cgccccactc tatggcgttg aaggaactaa 4140
aacaccagtt tcccctggtg aaatgagact gagggatgac cagaggaaag tcttcagaga 4200
actagtgagg aattgtgacc tgcccgtttg gctttcgtgg caagtggcca aggctggttt 4260
gaagacgaat gatcgtaagt ggtgttttga aggccctgag gaacatgaga tcttgaatga 4320
cagcggtgaa acagtgaagt gcagggctcc tggaggagca aagaagcctc tgcgcccaag 4380
gtggtgtgat gaaagggtgt catctgacca gagtgcgctg tctgaattta ttaagtttgc 4440
tgaaggtagg aggggagctg cggaagtgct agttgtgctg agtgaactcc ctgatttcct 4500
ggctaaaaaa ggtggagagg caatggatac catcagtgtg tttctccact ctgaggaagg 4560
ctctagggct taccgcaatg cactatcaat gatgcctgag gcaatgacaa tagtcatgct 4620
gtttatactg gctggactac tgacatcggg aatggtcatc tttttcatgt ctcccaaagg 4680
catcagtaga atgtctatgg cgatgggcac aatggccggc tgtggatatc tcatgttcct 4740
tggaggcgtc aaacccactc acatctccta tatcatgctc atattctttg tcctgatggt 4800
ggttgtgatc cccgagccag ggcaacaaag gtccatccaa gacaaccaag tggcatacct 4860
cattattggc atcctgacgc tggtttcagt ggtggcagcc aacgagctag gcatgctgga 4920
gaaaaccaaa gaggacctct ttgggaagaa gaacttaatt ccatctagtg cttcaccctg 4980
gagttggccg gatcttgacc tgaagccagg agctgcctgg acagtgtacg ttggcattgt 5040
tacaatgctc tctccaatgt tgcaccactg gatcaaagtc gaatatggca acctgtctct 5100
gtctggaata gcccagtcag cctcagtcct ttctttcatg gacaagggga taccattcat 5160
gaagatgaat atctcggtca taatactgct ggtcagtggc tggaattcaa taacagtgat 5220
gcctctgctc tgtggcatag ggtgcgccat gctccactgg tctctcattt tacctggaat 5280
caaagcgcag cagtcaaagc ttgcacagag aagggtgttc catggcgttg ccaagaaccc 5340
tgtggttgat gggaatccaa cagttgacat tgaggaagct cctgaaatgc ctgcccttta 5400
tgagaagaaa ctggctctat atctccttct tgctctcagc ctagcttctg ttgccatgtg 5460
cagaacgccc ttttcattgg ctgaaggcat tgtcctagca tcagctgcct tagggccgct 5520
catagaggga aacaccagcc ttctttggaa tggacccatg gctgtctcca tgacaggagt 5580
catgcggggg aattactatg cttttgtggg agtcatgtac aatctatgga agatgaaaac 5640
tggacgccgg gggagtgcga atggaaaaac tttgggtgaa gtctggaaga gggaactgaa 5700
tctgttggac aagcaacagt ttgagttgta taaaaggacc gacattgtgg aggtggatcg 5760
tgatacggca cgcaggcatt tggccgaagg gaaggtggac accggggtgg cggtctccag 5820
ggggaccgca aagttaaggt ggttccatga gcgtggctat gtcaagctgg aaggtagggt 5880
gattgacctg gggtgtggcc gcggaggctg gtgttactac gctgctgcgc aaaaggaagt 5940
gagtggggtc aaaggattta ctcttggaag agacggccat gagaaaccca tgaatgtgca 6000
aagtctggga tggaacatca tcaccttcaa ggacaaaact gatatccacc gcctagaacc 6060
agtgaaatgt gacacccttt tgtgtgacat tggagagtca tcatcgtcat cggtcacaga 6120
gggggaaagg accgtgagag ttcttgatac tgtagaaaaa tggctggctt gtggggttga 6180
caacttctgt gtgaaggtgt tagctccata catgccagat gttcttgaga aactggaatt 6240
gctccaaagg aggtttggcg gaacagtgat caggaaccct ctctccagga attccactca 6300
tgaaatgtac tacgtgtctg gagcccgcag caatgtcaca tttactgtga accaaacatc 6360
ccgcctcctg atgaggagaa tgaggcgtcc aactggaaaa gtgaccctgg aggctgacgt 6420
catcctccca attgggacac gcagtgttga gacagacaag ggacccctgg acaaagaggc 6480
catagaagaa agggttgaga ggataaaatc tgagtacatg acctcttggt tttatgacaa 6540
tgacaacccc tacaggacct ggcactactg tggctcctat gtcacaaaaa cctcaggaag 6600
tgcggcgagc atggtaaatg gtgttattaa aattctgaca tacccatggg acaggataga 6660
ggaggtcaca agaatggcaa tgactgacac aacccctttt ggacagcaaa gagtgtttaa 6720
agaaaaagtt gacaccagag caaaggatcc accagcggga actaggaaga tcatgaaagt 6780
tgtcaacagg tggctgttcc gccacctggc cagagaaaag aaccccagac tgtgcacaaa 6840
ggaagaattt attgcaaaag tccgaagtca tgcagccatt ggagcttacc tggaagaaca 6900
agaacagtgg aagactgcca atgaggctgt ccaagaccca aagttctggg aactggtgga 6960
tgaagaaagg aagctgcacc aacaaggcag gtgtcggact tgtgtgtaca acatgatggg 7020
gaaaagagag aagaagctgt cagagtttgg gaaagcaaag ggaagccgtg ccatatggta 7080
tatgtggctg ggagcgcggt atcttgagtt tgaggccctg ggattcctga atgaggacca 7140
ttgggcttcc agggaaaact caggaggagg agtggaaggc attggcttac aatacctagg 7200
atatgtgatc agagacctgg ctgcaatgga tggtggtgga ttctacgcgg atgacaccgc 7260
tggatgggac acgcgcatca cagaggcaga ccttgatgat gaacaggaga tcttgaacta 7320
catgagccca catcacaaaa aactggcaca agcagtgatg gaaatgacat acaagaacaa 7380
agtggtgaaa gtgttgagac cagccccagg agggaaagcc tacatggatg tcataagtcg 7440
acgagaccag agaggatccg ggcaggtagt gacttatgct ctgaacacca tcaccaactt 7500
gaaagtccaa ttgatcagaa tggcagaagc agagatggtg atacatcacc aacatgttca 7560
agattgtgat gaatcagttc tgaccaggct ggaggcatgg ctcactgagc acggatgtaa 7620
cagactgaag aggatggcgg tgagtggaga cgactgtgtg gtccggccca tcgatgacag 7680
gttcggcctg gccctgtccc atctcaacgc catgtccaag gttagaaagg acatatctga 7740
atggcagcca tcaaaagggt ggaatgattg ggagaatgtg cccttctgtt cccaccactt 7800
ccatgaacta cagctgaagg atggcaggag gattgtggtg ccttgccgag aacaggacga 7860
gctcattggg agaggaaggg tgtctccagg aaacggctgg atgatcaagg aaacagcttg 7920
cctcagcaaa gcctatgcca acatgtggtc actgatgtat tttcacaaaa gggacatgag 7980
gctactgtca ttggctgttt cctcagctgt tcccacctca tgggttccac aaggacgcac 8040
aacatggtcg attcatggga aaggggagtg gatgaccacg gaagacatgc ttgaggtgtg 8100
gaacagagta tggataacca acaacccaca catgcaggac aagacaatgg tgaaagaatg 8160
gagagatgtc ccttatctaa ccaagagaca agacaagctg tgcggatcac tgattggaat 8220
gaccaatagg gccacctggg cctcccacat ccatttggtc atccatcgta tccgaacgct 8280
gattggacag gagaaatata ctgactacct aacagtcatg gacagatatt ctgtggatgc 8340
tgacctgcaa ccgggtgagc ttatctgaaa caccatctaa taggaataac cgggatacaa 8400
accacgggtg gagaaccgga ctccccacaa cttgaaaccg ggatataaac cacggctgga 8460
gaaccggact ccgcacttaa aatgaaacag aaaccgggat aaaaactacg gatggagaac 8520
cggactccac acattgagac agaagaagtt gtcagcccag aactccacac gagttttgcc 8580
actgctaagc tgtgaggcag tgcaggctgg gacagccgac ctccaggttg cgaaaaacct 8640
ggtttctggg acctcccacc ccagagtaaa aagaacggag cctccgctac caccctccca 8700
cgtggtggta gaaagacggg gtctagaggt tagaggagac cctccaggga acaaatagtg 8760
ggaccatatt gacgccaggg aaagaccgga gtggttctct gcttttcctc caggggtctg 8820
tgagcacagt ttgctcaaga ataagcagac ctttggatga caaacacaaa ac 8872
<210> 94
<211> 8419
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 94
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttaaaga gtgcccatgg 600
ctctccaaca ttttggatgg gaagtcatga agtaaatggg acatggatga tccacacctt 660
ggaggcatta gattacaagg agtgtgagtg gccactgaca catacgattg gaacatcagt 720
tgaagagagt gaaatgttca tgccgagatc aatcggaggc ccagttagct ctcacaatca 780
tatccctgga tacaaggttc agacgaacgg accttggatg caggtaccac tagaggtgaa 840
gagagaagct tgcccaggga ctagcgtgat cattgatggc aactgtgatg gacggggaaa 900
atcaaccaga tccaccacgg atagcgggaa aattattcct gaatggtgtt gccgctcctg 960
cacaatgccg cctgtgagct tccatggtag tgatgggtgt tggtatccca tggaaattag 1020
gccaaggaaa acgcatgaaa gccatctggt gcgctcctgg gttacagctg gagaaataca 1080
tgctgtccct tttggtttgg tgagcatgat gatagcaatg gaagtggtcc taaggaaaag 1140
acagggacca aagcaaatgt tggttggagg agtggtgctc ttgggagcaa tgctggtcgg 1200
gcaagtaact ctccttgatt tgctgaaact cacagtggct gtgggattgc atttccatga 1260
gatgaacaat ggaggagacg ccatgtatat ggcgttgatt gctgcctttt caatcagacc 1320
agggctgctc atcggctttg ggctcaggac cctatggagc cctcgggaac gccttgtgct 1380
gaccctagga gcagccatgg tggagattgc cttgggtggc atgatgggcg gcctgtggaa 1440
gtatctaaat gcagtttctc tctgcatcct gacaataaat gctgttgctt ctaggaaagc 1500
atcaaatacc atcttgcccc tcatggctct gttgacacct gtcactatgg ctgaggtgag 1560
acttgccaca atgctctttt gtaccgtggt tatcataggg gtccttcacc agaactccaa 1620
ggacacctcc atgcagaaga ctatacctct ggtggccctc acactcacat cttacctggg 1680
cttgacacaa ccttttttgg gcctgtgtgc atttctggca acccgcatat ttgggcgaag 1740
gagtatccca gtgaatgagg cactcgcagc agctggtcta gtgggagtgc tggcaggact 1800
ggcttttcag gagatggaga acttccttgg tccgattgca gttggaggaa tcctgatgat 1860
gctggttagc gtggctggga gggtggatgg gctagagctc aagaagcttg gtgaagtttc 1920
atgggaagag gaggcggaga tcagcggaag ttccgcccgc tatgatgtgg cactcagtga 1980
acaaggggag ttcaagctgc tttctgaaga gaaagtgcca tgggaccagg ttgtgatgac 2040
ctcgctggcc ttggttgggg ctgccattca tccatttgct cttctgctgg tccttgctgg 2100
gtggctgttt catgtcaggg gagctaggag aagtggggat gtcttgtggg atattcccac 2160
tcctaagatc attgaggaat gtgaacatct ggaggatggg atttatggca tattccagtc 2220
aaccttcttg ggggcctccc agcgaggagt gggagtggca cagggagggg tgttccacac 2280
aatgtggcat gtcacaagag gagctttcct tgtcaggaat ggcaagaagt tgattccatc 2340
ttgggcttca gtaaaggaag accttgtcgc ctatggtggc tcatggaagt tggaaggcag 2400
atgggatgga gaggaagagg tccaattgat cgctgctgtt ccaggaaaga acgtggtcaa 2460
cgtccagaca aaaccgagct tgttcaaagt gaggaatggg ggagaaatcg gggctgtcgc 2520
tcttgactat ccgagtggca cttcaggatc tcctattgtt aacaggaacg gagaggtgat 2580
tgggctgtac ggcaatggca tccttgtcgg tgacaactcc ttcgtgtccg ccatatccca 2640
gactgaggtg aaggaagaag gaaaggagga gctccaagag atcccgacaa tgctaaagaa 2700
aggaatgaca actatccttg attttcatcc tggagctggg aagacaagac gttttctccc 2760
acagatcttg gccgagtgcg cacggagacg cttgcgcact cttgtgttgg cccccaccag 2820
ggttgttctt tctgaaatga aggaggcttt tcacggcctg gacgtgaaat tccacacaca 2880
ggctttttcc gctcacggca gcgggagaga agtcattgat gccatgtgcc atgccaccct 2940
aacttacagg atgttggaac caactagggt tgttaactgg gaagtgatca tcatggatga 3000
agcccatttt ttggatccag ctagcatagc cgccagaggt tgggcagcgc acagagctag 3060
ggcaaatgaa agtgcaacaa tcttgatgac agccacaccg cctgggacta gtgatgaatt 3120
tccacattca aatggtgaaa tagaagatgt tcaaacggac atacccagtg agccctggaa 3180
cacagggcat gactggatcc tggctgacaa aaggcccacg gcatggttcc ttccatccat 3240
cagagctgca aatgtcatgg ctgcctcttt gcgtaaggct ggaaagagtg tggtggtcct 3300
gaacaggaaa acctttgaga gagaataccc cacgataaag cagaagaaac ctgactttat 3360
attggccact gacatagctg aaatgggagc caacctttgc gtggagcgag tgctggattg 3420
caggacggct tttaagcctg tgcttgtgga tgaagggagg aaggtggcaa taaaagggcc 3480
acttcgcatc tccgcatcct ctgctgctca aaggaggggg cgcattggga gaaatcccaa 3540
cagagatgga gactcatact actattctga gcccacaagt gaagataatg cccaccacgt 3600
ctgctggttg gaggcctcaa tgctcttgga caacatggag gtgaggggtg gaatggtcgc 3660
cccactctat ggcgttgaag gaactaaaac accagtttcc cctggtgaaa tgagactgag 3720
ggatgaccag aggaaagtct tcagagaact agtgaggaat tgtgacctgc ccgtttggct 3780
ttcgtggcaa gtggccaagg ctggtttgaa gacgaatgat cgtaagtggt gttttgaagg 3840
ccctgaggaa catgagatct tgaatgacag cggtgaaaca gtgaagtgca gggctcctgg 3900
aggagcaaag aagcctctgc gcccaaggtg gtgtgatgaa agggtgtcat ctgaccagag 3960
tgcgctgtct gaatttatta agtttgctga aggtaggagg ggagctgcgg aagtgctagt 4020
tgtgctgagt gaactccctg atttcctggc taaaaaaggt ggagaggcaa tggataccat 4080
cagtgtgttt ctccactctg aggaaggctc tagggcttac cgcaatgcac tatcaatgat 4140
gcctgaggca atgacaatag tcatgctgtt tatactggct ggactactga catcgggaat 4200
ggtcatcttt ttcatgtctc ccaaaggcat cagtagaatg tctatggcga tgggcacaat 4260
ggccggctgt ggatatctca tgttccttgg aggcgtcaaa cccactcaca tctcctatat 4320
catgctcata ttctttgtcc tgatggtggt tgtgatcccc gagccagggc aacaaaggtc 4380
catccaagac aaccaagtgg catacctcat tattggcatc ctgacgctgg tttcagtggt 4440
ggcagccaac gagctaggca tgctggagaa aaccaaagag gacctctttg ggaagaagaa 4500
cttaattcca tctagtgctt caccctggag ttggccggat cttgacctga agccaggagc 4560
tgcctggaca gtgtacgttg gcattgttac aatgctctct ccaatgttgc accactggat 4620
caaagtcgaa tatggcaacc tgtctctgtc tggaatagcc cagtcagcct cagtcctttc 4680
tttcatggac aaggggatac cattcatgaa gatgaatatc tcggtcataa tactgctggt 4740
cagtggctgg aattcaataa cagtgatgcc tctgctctgt ggcatagggt gcgccatgct 4800
ccactggtct ctcattttac ctggaatcaa agcgcagcag tcaaagcttg cacagagaag 4860
ggtgttccat ggcgttgcca agaaccctgt ggttgatggg aatccaacag ttgacattga 4920
ggaagctcct gaaatgcctg ccctttatga gaagaaactg gctctatatc tccttcttgc 4980
tctcagccta gcttctgttg ccatgtgcag aacgcccttt tcattggctg aaggcattgt 5040
cctagcatca gctgccttag ggccgctcat agagggaaac accagccttc tttggaatgg 5100
acccatggct gtctccatga caggagtcat gcgggggaat tactatgctt ttgtgggagt 5160
catgtacaat ctatggaaga tgaaaactgg acgccggggg agtgcgaatg gaaaaacttt 5220
gggtgaagtc tggaagaggg aactgaatct gttggacaag caacagtttg agttgtataa 5280
aaggaccgac attgtggagg tggatcgtga tacggcacgc aggcatttgg ccgaagggaa 5340
ggtggacacc ggggtggcgg tctccagggg gaccgcaaag ttaaggtggt tccatgagcg 5400
tggctatgtc aagctggaag gtagggtgat tgacctgggg tgtggccgcg gaggctggtg 5460
ttactacgct gctgcgcaaa aggaagtgag tggggtcaaa ggatttactc ttggaagaga 5520
cggccatgag aaacccatga atgtgcaaag tctgggatgg aacatcatca ccttcaagga 5580
caaaactgat atccaccgcc tagaaccagt gaaatgtgac acccttttgt gtgacattgg 5640
agagtcatca tcgtcatcgg tcacagaggg ggaaaggacc gtgagagttc ttgatactgt 5700
agaaaaatgg ctggcttgtg gggttgacaa cttctgtgtg aaggtgttag ctccatacat 5760
gccagatgtt cttgagaaac tggaattgct ccaaaggagg tttggcggaa cagtgatcag 5820
gaaccctctc tccaggaatt ccactcatga aatgtactac gtgtctggag cccgcagcaa 5880
tgtcacattt actgtgaacc aaacatcccg cctcctgatg aggagaatga ggcgtccaac 5940
tggaaaagtg accctggagg ctgacgtcat cctcccaatt gggacacgca gtgttgagac 6000
agacaaggga cccctggaca aagaggccat agaagaaagg gttgagagga taaaatctga 6060
gtacatgacc tcttggtttt atgacaatga caacccctac aggacctggc actactgtgg 6120
ctcctatgtc acaaaaacct caggaagtgc ggcgagcatg gtaaatggtg ttattaaaat 6180
tctgacatac ccatgggaca ggatagagga ggtcacaaga atggcaatga ctgacacaac 6240
cccttttgga cagcaaagag tgtttaaaga aaaagttgac accagagcaa aggatccacc 6300
agcgggaact aggaagatca tgaaagttgt caacaggtgg ctgttccgcc acctggccag 6360
agaaaagaac cccagactgt gcacaaagga agaatttatt gcaaaagtcc gaagtcatgc 6420
agccattgga gcttacctgg aagaacaaga acagtggaag actgccaatg aggctgtcca 6480
agacccaaag ttctgggaac tggtggatga agaaaggaag ctgcaccaac aaggcaggtg 6540
tcggacttgt gtgtacaaca tgatggggaa aagagagaag aagctgtcag agtttgggaa 6600
agcaaaggga agccgtgcca tatggtatat gtggctggga gcgcggtatc ttgagtttga 6660
ggccctggga ttcctgaatg aggaccattg ggcttccagg gaaaactcag gaggaggagt 6720
ggaaggcatt ggcttacaat acctaggata tgtgatcaga gacctggctg caatggatgg 6780
tggtggattc tacgcggatg acaccgctgg atgggacacg cgcatcacag aggcagacct 6840
tgatgatgaa caggagatct tgaactacat gagcccacat cacaaaaaac tggcacaagc 6900
agtgatggaa atgacataca agaacaaagt ggtgaaagtg ttgagaccag ccccaggagg 6960
gaaagcctac atggatgtca taagtcgacg agaccagaga ggatccgggc aggtagtgac 7020
ttatgctctg aacaccatca ccaacttgaa agtccaattg atcagaatgg cagaagcaga 7080
gatggtgata catcaccaac atgttcaaga ttgtgatgaa tcagttctga ccaggctgga 7140
ggcatggctc actgagcacg gatgtaacag actgaagagg atggcggtga gtggagacga 7200
ctgtgtggtc cggcccatcg atgacaggtt cggcctggcc ctgtcccatc tcaacgccat 7260
gtccaaggtt agaaaggaca tatctgaatg gcagccatca aaagggtgga atgattggga 7320
gaatgtgccc ttctgttccc accacttcca tgaactacag ctgaaggatg gcaggaggat 7380
tgtggtgcct tgccgagaac aggacgagct cattgggaga ggaagggtgt ctccaggaaa 7440
cggctggatg atcaaggaaa cagcttgcct cagcaaagcc tatgccaaca tgtggtcact 7500
gatgtatttt cacaaaaggg acatgaggct actgtcattg gctgtttcct cagctgttcc 7560
cacctcatgg gttccacaag gacgcacaac atggtcgatt catgggaaag gggagtggat 7620
gaccacggaa gacatgcttg aggtgtggaa cagagtatgg ataaccaaca acccacacat 7680
gcaggacaag acaatggtga aagaatggag agatgtccct tatctaacca agagacaaga 7740
caagctgtgc ggatcactga ttggaatgac caatagggcc acctgggcct cccacatcca 7800
tttggtcatc catcgtatcc gaacgctgat tggacaggag aaatatactg actacctaac 7860
agtcatggac agatattctg tggatgctga cctgcaaccg ggtgagctta tctgaaacac 7920
catctaatag gaataaccgg gatacaaacc acgggtggag aaccggactc cccacaactt 7980
gaaaccggga tataaaccac ggctggagaa ccggactccg cacttaaaat gaaacagaaa 8040
ccgggataaa aactacggat ggagaaccgg actccacaca ttgagacaga agaagttgtc 8100
agcccagaac tccacacgag ttttgccact gctaagctgt gaggcagtgc aggctgggac 8160
agccgacctc caggttgcga aaaacctggt ttctgggacc tcccacccca gagtaaaaag 8220
aacggagcct ccgctaccac cctcccacgt ggtggtagaa agacggggtc tagaggttag 8280
aggagaccct ccagggaaca aatagtggga ccatattgac gccagggaaa gaccggagtg 8340
gttctctgct tttcctccag gggtctgtga gcacagtttg ctcaagaata agcagacctt 8400
tggatgacaa acacaaaac 8419
<210> 95
<211> 9463
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 95
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggctcgtga ggaacccctt ttttgcagtg acagctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatggac ctgctgaggc 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gccgagttca ctgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa aaagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt aagagtgccc atggctctcc aacattttgg atgggaagtc atgaagtaaa 1680
tgggacatgg atgatccaca ccttggaggc attagattac aaggagtgtg agtggccact 1740
gacacatacg attggaacat cagttgaaga gagtgaaatg ttcatgccga gatcaatcgg 1800
aggcccagtt agctctcaca atcatatccc tggatacaag gttcagacga acggaccttg 1860
gatgcaggta ccactagagg tgaagagaga agcttgccca gggactagcg tgatcattga 1920
tggcaactgt gatggacggg gaaaatcaac cagatccacc acggatagcg ggaaaattat 1980
tcctgaatgg tgttgccgct cctgcacaat gccgcctgtg agcttccatg gtagtgatgg 2040
gtgttggtat cccatggaaa ttaggccaag gaaaacgcat gaaagccatc tggtgcgctc 2100
ctgggttaca gctggagaaa tacatgctgt cccttttggt ttggtgagca tgatgatagc 2160
aatggaagtg gtcctaagga aaagacaggg accaaagcaa atgttggttg gaggagtggt 2220
gctcttggga gcaatgctgg tcgggcaagt aactctcctt gatttgctga aactcacagt 2280
ggctgtggga ttgcatttcc atgagatgaa caatggagga gacgccatgt atatggcgtt 2340
gattgctgcc ttttcaatca gaccagggct gctcatcggc tttgggctca ggaccctatg 2400
gagccctcgg gaacgccttg tgctgaccct aggagcagcc atggtggaga ttgccttggg 2460
tggcatgatg ggcggcctgt ggaagtatct aaatgcagtt tctctctgca tcctgacaat 2520
aaatgctgtt gcttctagga aagcatcaaa taccatcttg cccctcatgg ctctgttgac 2580
acctgtcact atggctgagg tgagacttgc cacaatgctc ttttgtaccg tggttatcat 2640
aggggtcctt caccagaact ccaaggacac ctccatgcag aagactatac ctctggtggc 2700
cctcacactc acatcttacc tgggcttgac acaacctttt ttgggcctgt gtgcatttct 2760
ggcaacccgc atatttgggc gaaggagtat cccagtgaat gaggcactcg cagcagctgg 2820
tctagtggga gtgctggcag gactggcttt tcaggagatg gagaacttcc ttggtccgat 2880
tgcagttgga ggaatcctga tgatgctggt tagcgtggct gggagggtgg atgggctaga 2940
gctcaagaag cttggtgaag tttcatggga agaggaggcg gagatcagcg gaagttccgc 3000
ccgctatgat gtggcactca gtgaacaagg ggagttcaag ctgctttctg aagagaaagt 3060
gccatgggac caggttgtga tgacctcgct ggccttggtt ggggctgcca ttcatccatt 3120
tgctcttctg ctggtccttg ctgggtggct gtttcatgtc aggggagcta ggagaagtgg 3180
ggatgtcttg tgggatattc ccactcctaa gatcattgag gaatgtgaac atctggagga 3240
tgggatttat ggcatattcc agtcaacctt cttgggggcc tcccagcgag gagtgggagt 3300
ggcacaggga ggggtgttcc acacaatgtg gcatgtcaca agaggagctt tccttgtcag 3360
gaatggcaag aagttgattc catcttgggc ttcagtaaag gaagaccttg tcgcctatgg 3420
tggctcatgg aagttggaag gcagatggga tggagaggaa gaggtccaat tgatcgctgc 3480
tgttccagga aagaacgtgg tcaacgtcca gacaaaaccg agcttgttca aagtgaggaa 3540
tgggggagaa atcggggctg tcgctcttga ctatccgagt ggcacttcag gatctcctat 3600
tgttaacagg aacggagagg tgattgggct gtacggcaat ggcatccttg tcggtgacaa 3660
ctccttcgtg tccgccatat cccagactga ggtgaaggaa gaaggaaagg aggagctcca 3720
agagatcccg acaatgctaa agaaaggaat gacaactatc cttgattttc atcctggagc 3780
tgggaagaca agacgttttc tcccacagat cttggccgag tgcgcacgga gacgcttgcg 3840
cactcttgtg ttggccccca ccagggttgt tctttctgaa atgaaggagg cttttcacgg 3900
cctggacgtg aaattccaca cacaggcttt ttccgctcac ggcagcggga gagaagtcat 3960
tgatgccatg tgccatgcca ccctaactta caggatgttg gaaccaacta gggttgttaa 4020
ctgggaagtg atcatcatgg atgaagccca ttttttggat ccagctagca tagccgccag 4080
aggttgggca gcgcacagag ctagggcaaa tgaaagtgca acaatcttga tgacagccac 4140
accgcctggg actagtgatg aatttccaca ttcaaatggt gaaatagaag atgttcaaac 4200
ggacataccc agtgagccct ggaacacagg gcatgactgg atcctggctg acaaaaggcc 4260
cacggcatgg ttccttccat ccatcagagc tgcaaatgtc atggctgcct ctttgcgtaa 4320
ggctggaaag agtgtggtgg tcctgaacag gaaaaccttt gagagagaat accccacgat 4380
aaagcagaag aaacctgact ttatattggc cactgacata gctgaaatgg gagccaacct 4440
ttgcgtggag cgagtgctgg attgcaggac ggcttttaag cctgtgcttg tggatgaagg 4500
gaggaaggtg gcaataaaag ggccacttcg catctccgca tcctctgctg ctcaaaggag 4560
ggggcgcatt gggagaaatc ccaacagaga tggagactca tactactatt ctgagcccac 4620
aagtgaagat aatgcccacc acgtctgctg gttggaggcc tcaatgctct tggacaacat 4680
ggaggtgagg ggtggaatgg tcgccccact ctatggcgtt gaaggaacta aaacaccagt 4740
ttcccctggt gaaatgagac tgagggatga ccagaggaaa gtcttcagag aactagtgag 4800
gaattgtgac ctgcccgttt ggctttcgtg gcaagtggcc aaggctggtt tgaagacgaa 4860
tgatcgtaag tggtgttttg aaggccctga ggaacatgag atcttgaatg acagcggtga 4920
aacagtgaag tgcagggctc ctggaggagc aaagaagcct ctgcgcccaa ggtggtgtga 4980
tgaaagggtg tcatctgacc agagtgcgct gtctgaattt attaagtttg ctgaaggtag 5040
gaggggagct gcggaagtgc tagttgtgct gagtgaactc cctgatttcc tggctaaaaa 5100
aggtggagag gcaatggata ccatcagtgt gtttctccac tctgaggaag gctctagggc 5160
ttaccgcaat gcactatcaa tgatgcctga ggcaatgaca atagtcatgc tgtttatact 5220
ggctggacta ctgacatcgg gaatggtcat ctttttcatg tctcccaaag gcatcagtag 5280
aatgtctatg gcgatgggca caatggccgg ctgtggatat ctcatgttcc ttggaggcgt 5340
caaacccact cacatctcct atatcatgct catattcttt gtcctgatgg tggttgtgat 5400
ccccgagcca gggcaacaaa ggtccatcca agacaaccaa gtggcatacc tcattattgg 5460
catcctgacg ctggtttcag tggtggcagc caacgagcta ggcatgctgg agaaaaccaa 5520
agaggacctc tttgggaaga agaacttaat tccatctagt gcttcaccct ggagttggcc 5580
ggatcttgac ctgaagccag gagctgcctg gacagtgtac gttggcattg ttacaatgct 5640
ctctccaatg ttgcaccact ggatcaaagt cgaatatggc aacctgtctc tgtctggaat 5700
agcccagtca gcctcagtcc tttctttcat ggacaagggg ataccattca tgaagatgaa 5760
tatctcggtc ataatactgc tggtcagtgg ctggaattca ataacagtga tgcctctgct 5820
ctgtggcata gggtgcgcca tgctccactg gtctctcatt ttacctggaa tcaaagcgca 5880
gcagtcaaag cttgcacaga gaagggtgtt ccatggcgtt gccaagaacc ctgtggttga 5940
tgggaatcca acagttgaca ttgaggaagc tcctgaaatg cctgcccttt atgagaagaa 6000
actggctcta tatctccttc ttgctctcag cctagcttct gttgccatgt gcagaacgcc 6060
cttttcattg gctgaaggca ttgtcctagc atcagctgcc ttagggccgc tcatagaggg 6120
aaacaccagc cttctttgga atggacccat ggctgtctcc atgacaggag tcatgcgggg 6180
gaattactat gcttttgtgg gagtcatgta caatctatgg aagatgaaaa ctggacgccg 6240
ggggagtgcg aatggaaaaa ctttgggtga agtctggaag agggaactga atctgttgga 6300
caagcaacag tttgagttgt ataaaaggac cgacattgtg gaggtggatc gtgatacggc 6360
acgcaggcat ttggccgaag ggaaggtgga caccggggtg gcggtctcca gggggaccgc 6420
aaagttaagg tggttccatg agcgtggcta tgtcaagctg gaaggtaggg tgattgacct 6480
ggggtgtggc cgcggaggct ggtgttacta cgctgctgcg caaaaggaag tgagtggggt 6540
caaaggattt actcttggaa gagacggcca tgagaaaccc atgaatgtgc aaagtctggg 6600
atggaacatc atcaccttca aggacaaaac tgatatccac cgcctagaac cagtgaaatg 6660
tgacaccctt ttgtgtgaca ttggagagtc atcatcgtca tcggtcacag agggggaaag 6720
gaccgtgaga gttcttgata ctgtagaaaa atggctggct tgtggggttg acaacttctg 6780
tgtgaaggtg ttagctccat acatgccaga tgttcttgag aaactggaat tgctccaaag 6840
gaggtttggc ggaacagtga tcaggaaccc tctctccagg aattccactc atgaaatgta 6900
ctacgtgtct ggagcccgca gcaatgtcac atttactgtg aaccaaacat cccgcctcct 6960
gatgaggaga atgaggcgtc caactggaaa agtgaccctg gaggctgacg tcatcctccc 7020
aattgggaca cgcagtgttg agacagacaa gggacccctg gacaaagagg ccatagaaga 7080
aagggttgag aggataaaat ctgagtacat gacctcttgg ttttatgaca atgacaaccc 7140
ctacaggacc tggcactact gtggctccta tgtcacaaaa acctcaggaa gtgcggcgag 7200
catggtaaat ggtgttatta aaattctgac atacccatgg gacaggatag aggaggtcac 7260
aagaatggca atgactgaca caaccccttt tggacagcaa agagtgttta aagaaaaagt 7320
tgacaccaga gcaaaggatc caccagcggg aactaggaag atcatgaaag ttgtcaacag 7380
gtggctgttc cgccacctgg ccagagaaaa gaaccccaga ctgtgcacaa aggaagaatt 7440
tattgcaaaa gtccgaagtc atgcagccat tggagcttac ctggaagaac aagaacagtg 7500
gaagactgcc aatgaggctg tccaagaccc aaagttctgg gaactggtgg atgaagaaag 7560
gaagctgcac caacaaggca ggtgtcggac ttgtgtgtac aacatgatgg ggaaaagaga 7620
gaagaagctg tcagagtttg ggaaagcaaa gggaagccgt gccatatggt atatgtggct 7680
gggagcgcgg tatcttgagt ttgaggccct gggattcctg aatgaggacc attgggcttc 7740
cagggaaaac tcaggaggag gagtggaagg cattggctta caatacctag gatatgtgat 7800
cagagacctg gctgcaatgg atggtggtgg attctacgcg gatgacaccg ctggatggga 7860
cacgcgcatc acagaggcag accttgatga tgaacaggag atcttgaact acatgagccc 7920
acatcacaaa aaactggcac aagcagtgat ggaaatgaca tacaagaaca aagtggtgaa 7980
agtgttgaga ccagccccag gagggaaagc ctacatggat gtcataagtc gacgagacca 8040
gagaggatcc gggcaggtag tgacttatgc tctgaacacc atcaccaact tgaaagtcca 8100
attgatcaga atggcagaag cagagatggt gatacatcac caacatgttc aagattgtga 8160
tgaatcagtt ctgaccaggc tggaggcatg gctcactgag cacggatgta acagactgaa 8220
gaggatggcg gtgagtggag acgactgtgt ggtccggccc atcgatgaca ggttcggcct 8280
ggccctgtcc catctcaacg ccatgtccaa ggttagaaag gacatatctg aatggcagcc 8340
atcaaaaggg tggaatgatt gggagaatgt gcccttctgt tcccaccact tccatgaact 8400
acagctgaag gatggcagga ggattgtggt gccttgccga gaacaggacg agctcattgg 8460
gagaggaagg gtgtctccag gaaacggctg gatgatcaag gaaacagctt gcctcagcaa 8520
agcctatgcc aacatgtggt cactgatgta ttttcacaaa agggacatga ggctactgtc 8580
attggctgtt tcctcagctg ttcccacctc atgggttcca caaggacgca caacatggtc 8640
gattcatggg aaaggggagt ggatgaccac ggaagacatg cttgaggtgt ggaacagagt 8700
atggataacc aacaacccac acatgcagga caagacaatg gtgaaagaat ggagagatgt 8760
cccttatcta accaagagac aagacaagct gtgcggatca ctgattggaa tgaccaatag 8820
ggccacctgg gcctcccaca tccatttggt catccatcgt atccgaacgc tgattggaca 8880
ggagaaatat actgactacc taacagtcat ggacagatat tctgtggatg ctgacctgca 8940
accgggtgag cttatctgaa acaccatcta ataggaataa ccgggataca aaccacgggt 9000
ggagaaccgg actccccaca acttgaaacc gggatataaa ccacggctgg agaaccggac 9060
tccgcactta aaatgaaaca gaaaccggga taaaaactac ggatggagaa ccggactcca 9120
cacattgaga cagaagaagt tgtcagccca gaactccaca cgagttttgc cactgctaag 9180
ctgtgaggca gtgcaggctg ggacagccga cctccaggtt gcgaaaaacc tggtttctgg 9240
gacctcccac cccagagtaa aaagaacgga gcctccgcta ccaccctccc acgtggtggt 9300
agaaagacgg ggtctagagg ttagaggaga ccctccaggg aacaaatagt gggaccatat 9360
tgacgccagg gaaagaccgg agtggttctc tgcttttcct ccaggggtct gtgagcacag 9420
tttgctcaag aataagcaga cctttggatg acaaacacaa aac 9463
<210> 96
<211> 10351
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 96
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggctcgtga ggaacccctt ttttgcagtg acagctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatggac ctgctgaggc 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gccgagttca ctgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa aaagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt ggaagtggcg gggtgtggag agagatgcat catcttgtcg aatttgaacc 1680
tccgcatgcc gccactatca gagtactggc cctgggaaac caggaaggct ccttgaaaac 1740
agctcttacc ggcgcaatga gggttacaaa ggacacaaat gacaacaacc tttacaaact 1800
acatggtgga catgtttcct gcagagtgaa attgtcagct ttgacactca aggggacatc 1860
ctacaaaatg tgcactgaca aaatgtcttt tgtcaagaac ccaactgaca ctggccatgg 1920
cactgttgtg atgcaggtga aagtgccaaa aggagccccc tgcaagattc cagtgatagt 1980
agctgatgat cttacagcgg caatcaataa aggcattttg gttacagtta accccatcgc 2040
ctcaaccaat gatgatgaag tgctgattga ggtgaaccca ccttttggag acagctacat 2100
tatcgttggg acaggagatt cacgtctcac ttaccagtgg cacaaagagg gaagctcaat 2160
aggaaagttg ttcactcaga ccatgaaagg cgcggaacgc ctggccgtca tgggagacgc 2220
cgcctgggat ttcagctccg ctggagggtt cttcacttcg gttgggaaag gaattcatac 2280
ggtgtttggc tctgcctttc aggggctatt tggcggcttg aactggataa caaaggtcat 2340
catgggggcg gtactcatat gggttggcat caacacaaga aacatgacaa tgtccatgag 2400
catgatcttg gtaggagtga tcatgatgtt tttgtctcta ggagttgggg cggatcaagg 2460
atgcgccatc aactttggca agagagagct caagtgcgga gatggtatct tcatatttag 2520
agactctgat gactggctga acaagtactc atactatcca gaagatcctg tgaagctggc 2580
atcaatagtg aaagaggcat tagattacaa ggagtgtgag tggccactga cacatacgat 2640
tggaacatca gttgaagaga gtgaaatgtt catgccgaga tcaatcggag gcccagttag 2700
ctctcacaat catatccctg gatacaaggt tcagacgaac ggaccttgga tgcaggtacc 2760
actagaggtg aagagagaag cttgcccagg gactagcgtg atcattgatg gcaactgtga 2820
tggacgggga aaatcaacca gatccaccac ggatagcggg aaaattattc ctgaatggtg 2880
ttgccgctcc tgcacaatgc cgcctgtgag cttccatggt agtgatgggt gttggtatcc 2940
catggaaatt aggccaagga aaacgcatga aagccatctg gtgcgctcct gggttacagc 3000
tggagaaata catgctgtcc cttttggttt ggtgagcatg atgatagcaa tggaagtggt 3060
cctaaggaaa agacagggac caaagcaaat gttggttgga ggagtggtgc tcttgggagc 3120
aatgctggtc gggcaagtaa ctctccttga tttgctgaaa ctcacagtgg ctgtgggatt 3180
gcatttccat gagatgaaca atggaggaga cgccatgtat atggcgttga ttgctgcctt 3240
ttcaatcaga ccagggctgc tcatcggctt tgggctcagg accctatgga gccctcggga 3300
acgccttgtg ctgaccctag gagcagccat ggtggagatt gccttgggtg gcatgatggg 3360
cggcctgtgg aagtatctaa atgcagtttc tctctgcatc ctgacaataa atgctgttgc 3420
ttctaggaaa gcatcaaata ccatcttgcc cctcatggct ctgttgacac ctgtcactat 3480
ggctgaggtg agacttgcca caatgctctt ttgtaccgtg gttatcatag gggtccttca 3540
ccagaactcc aaggacacct ccatgcagaa gactatacct ctggtggccc tcacactcac 3600
atcttacctg ggcttgacac aacctttttt gggcctgtgt gcatttctgg caacccgcat 3660
atttgggcga aggagtatcc cagtgaatga ggcactcgca gcagctggtc tagtgggagt 3720
gctggcagga ctggcttttc aggagatgga gaacttcctt ggtccgattg cagttggagg 3780
aatcctgatg atgctggtta gcgtggctgg gagggtggat gggctagagc tcaagaagct 3840
tggtgaagtt tcatgggaag aggaggcgga gatcagcgga agttccgccc gctatgatgt 3900
ggcactcagt gaacaagggg agttcaagct gctttctgaa gagaaagtgc catgggacca 3960
ggttgtgatg acctcgctgg ccttggttgg ggctgccatt catccatttg ctcttctgct 4020
ggtccttgct gggtggctgt ttcatgtcag gggagctagg agaagtgggg atgtcttgtg 4080
ggatattccc actcctaaga tcattgagga atgtgaacat ctggaggatg ggatttatgg 4140
catattccag tcaaccttct tgggggcctc ccagcgagga gtgggagtgg cacagggagg 4200
ggtgttccac acaatgtggc atgtcacaag aggagctttc cttgtcagga atggcaagaa 4260
gttgattcca tcttgggctt cagtaaagga agaccttgtc gcctatggtg gctcatggaa 4320
gttggaaggc agatgggatg gagaggaaga ggtccaattg atcgctgctg ttccaggaaa 4380
gaacgtggtc aacgtccaga caaaaccgag cttgttcaaa gtgaggaatg ggggagaaat 4440
cggggctgtc gctcttgact atccgagtgg cacttcagga tctcctattg ttaacaggaa 4500
cggagaggtg attgggctgt acggcaatgg catccttgtc ggtgacaact ccttcgtgtc 4560
cgccatatcc cagactgagg tgaaggaaga aggaaaggag gagctccaag agatcccgac 4620
aatgctaaag aaaggaatga caactatcct tgattttcat cctggagctg ggaagacaag 4680
acgttttctc ccacagatct tggccgagtg cgcacggaga cgcttgcgca ctcttgtgtt 4740
ggcccccacc agggttgttc tttctgaaat gaaggaggct tttcacggcc tggacgtgaa 4800
attccacaca caggcttttt ccgctcacgg cagcgggaga gaagtcattg atgccatgtg 4860
ccatgccacc ctaacttaca ggatgttgga accaactagg gttgttaact gggaagtgat 4920
catcatggat gaagcccatt ttttggatcc agctagcata gccgccagag gttgggcagc 4980
gcacagagct agggcaaatg aaagtgcaac aatcttgatg acagccacac cgcctgggac 5040
tagtgatgaa tttccacatt caaatggtga aatagaagat gttcaaacgg acatacccag 5100
tgagccctgg aacacagggc atgactggat cctggctgac aaaaggccca cggcatggtt 5160
ccttccatcc atcagagctg caaatgtcat ggctgcctct ttgcgtaagg ctggaaagag 5220
tgtggtggtc ctgaacagga aaacctttga gagagaatac cccacgataa agcagaagaa 5280
acctgacttt atattggcca ctgacatagc tgaaatggga gccaaccttt gcgtggagcg 5340
agtgctggat tgcaggacgg cttttaagcc tgtgcttgtg gatgaaggga ggaaggtggc 5400
aataaaaggg ccacttcgca tctccgcatc ctctgctgct caaaggaggg ggcgcattgg 5460
gagaaatccc aacagagatg gagactcata ctactattct gagcccacaa gtgaagataa 5520
tgcccaccac gtctgctggt tggaggcctc aatgctcttg gacaacatgg aggtgagggg 5580
tggaatggtc gccccactct atggcgttga aggaactaaa acaccagttt cccctggtga 5640
aatgagactg agggatgacc agaggaaagt cttcagagaa ctagtgagga attgtgacct 5700
gcccgtttgg ctttcgtggc aagtggccaa ggctggtttg aagacgaatg atcgtaagtg 5760
gtgttttgaa ggccctgagg aacatgagat cttgaatgac agcggtgaaa cagtgaagtg 5820
cagggctcct ggaggagcaa agaagcctct gcgcccaagg tggtgtgatg aaagggtgtc 5880
atctgaccag agtgcgctgt ctgaatttat taagtttgct gaaggtagga ggggagctgc 5940
ggaagtgcta gttgtgctga gtgaactccc tgatttcctg gctaaaaaag gtggagaggc 6000
aatggatacc atcagtgtgt ttctccactc tgaggaaggc tctagggctt accgcaatgc 6060
actatcaatg atgcctgagg caatgacaat agtcatgctg tttatactgg ctggactact 6120
gacatcggga atggtcatct ttttcatgtc tcccaaaggc atcagtagaa tgtctatggc 6180
gatgggcaca atggccggct gtggatatct catgttcctt ggaggcgtca aacccactca 6240
catctcctat atcatgctca tattctttgt cctgatggtg gttgtgatcc ccgagccagg 6300
gcaacaaagg tccatccaag acaaccaagt ggcatacctc attattggca tcctgacgct 6360
ggtttcagtg gtggcagcca acgagctagg catgctggag aaaaccaaag aggacctctt 6420
tgggaagaag aacttaattc catctagtgc ttcaccctgg agttggccgg atcttgacct 6480
gaagccagga gctgcctgga cagtgtacgt tggcattgtt acaatgctct ctccaatgtt 6540
gcaccactgg atcaaagtcg aatatggcaa cctgtctctg tctggaatag cccagtcagc 6600
ctcagtcctt tctttcatgg acaaggggat accattcatg aagatgaata tctcggtcat 6660
aatactgctg gtcagtggct ggaattcaat aacagtgatg cctctgctct gtggcatagg 6720
gtgcgccatg ctccactggt ctctcatttt acctggaatc aaagcgcagc agtcaaagct 6780
tgcacagaga agggtgttcc atggcgttgc caagaaccct gtggttgatg ggaatccaac 6840
agttgacatt gaggaagctc ctgaaatgcc tgccctttat gagaagaaac tggctctata 6900
tctccttctt gctctcagcc tagcttctgt tgccatgtgc agaacgccct tttcattggc 6960
tgaaggcatt gtcctagcat cagctgcctt agggccgctc atagagggaa acaccagcct 7020
tctttggaat ggacccatgg ctgtctccat gacaggagtc atgcggggga attactatgc 7080
ttttgtggga gtcatgtaca atctatggaa gatgaaaact ggacgccggg ggagtgcgaa 7140
tggaaaaact ttgggtgaag tctggaagag ggaactgaat ctgttggaca agcaacagtt 7200
tgagttgtat aaaaggaccg acattgtgga ggtggatcgt gatacggcac gcaggcattt 7260
ggccgaaggg aaggtggaca ccggggtggc ggtctccagg gggaccgcaa agttaaggtg 7320
gttccatgag cgtggctatg tcaagctgga aggtagggtg attgacctgg ggtgtggccg 7380
cggaggctgg tgttactacg ctgctgcgca aaaggaagtg agtggggtca aaggatttac 7440
tcttggaaga gacggccatg agaaacccat gaatgtgcaa agtctgggat ggaacatcat 7500
caccttcaag gacaaaactg atatccaccg cctagaacca gtgaaatgtg acaccctttt 7560
gtgtgacatt ggagagtcat catcgtcatc ggtcacagag ggggaaagga ccgtgagagt 7620
tcttgatact gtagaaaaat ggctggcttg tggggttgac aacttctgtg tgaaggtgtt 7680
agctccatac atgccagatg ttcttgagaa actggaattg ctccaaagga ggtttggcgg 7740
aacagtgatc aggaaccctc tctccaggaa ttccactcat gaaatgtact acgtgtctgg 7800
agcccgcagc aatgtcacat ttactgtgaa ccaaacatcc cgcctcctga tgaggagaat 7860
gaggcgtcca actggaaaag tgaccctgga ggctgacgtc atcctcccaa ttgggacacg 7920
cagtgttgag acagacaagg gacccctgga caaagaggcc atagaagaaa gggttgagag 7980
gataaaatct gagtacatga cctcttggtt ttatgacaat gacaacccct acaggacctg 8040
gcactactgt ggctcctatg tcacaaaaac ctcaggaagt gcggcgagca tggtaaatgg 8100
tgttattaaa attctgacat acccatggga caggatagag gaggtcacaa gaatggcaat 8160
gactgacaca accccttttg gacagcaaag agtgtttaaa gaaaaagttg acaccagagc 8220
aaaggatcca ccagcgggaa ctaggaagat catgaaagtt gtcaacaggt ggctgttccg 8280
ccacctggcc agagaaaaga accccagact gtgcacaaag gaagaattta ttgcaaaagt 8340
ccgaagtcat gcagccattg gagcttacct ggaagaacaa gaacagtgga agactgccaa 8400
tgaggctgtc caagacccaa agttctggga actggtggat gaagaaagga agctgcacca 8460
acaaggcagg tgtcggactt gtgtgtacaa catgatgggg aaaagagaga agaagctgtc 8520
agagtttggg aaagcaaagg gaagccgtgc catatggtat atgtggctgg gagcgcggta 8580
tcttgagttt gaggccctgg gattcctgaa tgaggaccat tgggcttcca gggaaaactc 8640
aggaggagga gtggaaggca ttggcttaca atacctagga tatgtgatca gagacctggc 8700
tgcaatggat ggtggtggat tctacgcgga tgacaccgct ggatgggaca cgcgcatcac 8760
agaggcagac cttgatgatg aacaggagat cttgaactac atgagcccac atcacaaaaa 8820
actggcacaa gcagtgatgg aaatgacata caagaacaaa gtggtgaaag tgttgagacc 8880
agccccagga gggaaagcct acatggatgt cataagtcga cgagaccaga gaggatccgg 8940
gcaggtagtg acttatgctc tgaacaccat caccaacttg aaagtccaat tgatcagaat 9000
ggcagaagca gagatggtga tacatcacca acatgttcaa gattgtgatg aatcagttct 9060
gaccaggctg gaggcatggc tcactgagca cggatgtaac agactgaaga ggatggcggt 9120
gagtggagac gactgtgtgg tccggcccat cgatgacagg ttcggcctgg ccctgtccca 9180
tctcaacgcc atgtccaagg ttagaaagga catatctgaa tggcagccat caaaagggtg 9240
gaatgattgg gagaatgtgc ccttctgttc ccaccacttc catgaactac agctgaagga 9300
tggcaggagg attgtggtgc cttgccgaga acaggacgag ctcattggga gaggaagggt 9360
gtctccagga aacggctgga tgatcaagga aacagcttgc ctcagcaaag cctatgccaa 9420
catgtggtca ctgatgtatt ttcacaaaag ggacatgagg ctactgtcat tggctgtttc 9480
ctcagctgtt cccacctcat gggttccaca aggacgcaca acatggtcga ttcatgggaa 9540
aggggagtgg atgaccacgg aagacatgct tgaggtgtgg aacagagtat ggataaccaa 9600
caacccacac atgcaggaca agacaatggt gaaagaatgg agagatgtcc cttatctaac 9660
caagagacaa gacaagctgt gcggatcact gattggaatg accaataggg ccacctgggc 9720
ctcccacatc catttggtca tccatcgtat ccgaacgctg attggacagg agaaatatac 9780
tgactaccta acagtcatgg acagatattc tgtggatgct gacctgcaac cgggtgagct 9840
tatctgaaac accatctaat aggaataacc gggatacaaa ccacgggtgg agaaccggac 9900
tccccacaac ttgaaaccgg gatataaacc acggctggag aaccggactc cgcacttaaa 9960
atgaaacaga aaccgggata aaaactacgg atggagaacc ggactccaca cattgagaca 10020
gaagaagttg tcagcccaga actccacacg agttttgcca ctgctaagct gtgaggcagt 10080
gcaggctggg acagccgacc tccaggttgc gaaaaacctg gtttctggga cctcccaccc 10140
cagagtaaaa agaacggagc ctccgctacc accctcccac gtggtggtag aaagacgggg 10200
tctagaggtt agaggagacc ctccagggaa caaatagtgg gaccatattg acgccaggga 10260
aagaccggag tggttctctg cttttcctcc aggggtctgt gagcacagtt tgctcaagaa 10320
taagcagacc tttggatgac aaacacaaaa c 10351
<210> 97
<211> 10850
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 97
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggctcgtga ggaacccctt ttttgcagtg acagctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatggac ctgctgaggc 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gccgagttca ctgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa aaagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt ggaagtggcg gggtgtggag agagatgcat catcttgtcg aatttgaacc 1680
tccgcatgcc gccactatca gagtactggc cctgggaaac caggaaggct ccttgaaaac 1740
agctcttacc ggcgcaatga gggttacaaa ggacacaaat gacaacaacc tttacaaact 1800
acatggtgga catgtttcct gcagagtgaa attgtcagct ttgacactca aggggacatc 1860
ctacaaaatg tgcactgaca aaatgtcttt tgtcaagaac ccaactgaca ctggccatgg 1920
cactgttgtg atgcaggtga aagtgccaaa aggagccccc tgcaagattc cagtgatagt 1980
agctgatgat cttacagcgg caatcaataa aggcattttg gttacagtta accccatcgc 2040
ctcaaccaat gatgatgaag tgctgattga ggtgaaccca ccttttggag acagctacat 2100
tatcgttggg acaggagatt cacgtctcac ttaccagtgg cacaaagagg gaagctcaat 2160
aggaaagttg ttcactcaga ccatgaaagg cgcggaacgc ctggccgtca tgggagacgc 2220
cgcctgggat ttcagctccg ctggagggtt cttcacttcg gttgggaaag gaattcatac 2280
ggtgtttggc tctgcctttc aggggctatt tggcggcttg aactggataa caaaggtcat 2340
catgggggcg gtactcatat gggttggcat caacacaaga aacatgacaa tgtccatgag 2400
catgatcttg gtaggagtga tcatgatgtt tttgtctcta ggagttgggg cggatcaagg 2460
atgcgccatc aactttggca agagagagct caagtgcgga gatggtatct tcatatttag 2520
agactctgat gactggctga acaagtactc atactatcca gaagatcctg tgaagctggc 2580
atcaatagtg aaagcctctt ttgaagaagg gaagtgtggc ctaaattcag ttgactccct 2640
tgagcatgag atgtggagaa gcagggcaga tgagatcaat gccattcttg aggaaaacga 2700
ggtggacatt tctgttgtcg tgcaggatcc aaagaatgtt taccagagag gaactcatcc 2760
attttccaga attcgggatg gtctgcagta tggttggaag acttggggta agaaccttgt 2820
gttctcccca gggaggaaga atggaagctt catcatagat ggaaagtcca ggaaagaatg 2880
cccgttttca aaccgggtct ggaattcttt ccagatagag gagtttggga cgggagtgtt 2940
caccacacgc gtgtacatgg acgcagtctt tgaatacacc atagactgcg atggatctat 3000
cttgggtgca gcggtgaacg gaaaaaagag tgcccatggc tctccaacat tttggatggg 3060
aagtcatgaa gtaaatggga catggatgat ccacaccttg gaggcattag attacaagga 3120
gtgtgagtgg ccactgacac atacgattgg aacatcagtt gaagagagtg aaatgttcat 3180
gccgagatca atcggaggcc cagttagctc tcacaatcat atccctggat acaaggttca 3240
gacgaacgga ccttggatgc aggtaccact agaggtgaag agagaagctt gcccagggac 3300
tagcgtgatc attgatggca actgtgatgg acggggaaaa tcaaccagat ccaccacgga 3360
tagcgggaaa attattcctg aatggtgttg ccgctcctgc acaatgccgc ctgtgagctt 3420
ccatggtagt gatgggtgtt ggtatcccat ggaaattagg ccaaggaaaa cgcatgaaag 3480
ccatctggtg cgctcctggg ttacagctgg agaaatacat gctgtccctt ttggtttggt 3540
gagcatgatg atagcaatgg aagtggtcct aaggaaaaga cagggaccaa agcaaatgtt 3600
ggttggagga gtggtgctct tgggagcaat gctggtcggg caagtaactc tccttgattt 3660
gctgaaactc acagtggctg tgggattgca tttccatgag atgaacaatg gaggagacgc 3720
catgtatatg gcgttgattg ctgccttttc aatcagacca gggctgctca tcggctttgg 3780
gctcaggacc ctatggagcc ctcgggaacg ccttgtgctg accctaggag cagccatggt 3840
ggagattgcc ttgggtggca tgatgggcgg cctgtggaag tatctaaatg cagtttctct 3900
ctgcatcctg acaataaatg ctgttgcttc taggaaagca tcaaatacca tcttgcccct 3960
catggctctg ttgacacctg tcactatggc tgaggtgaga cttgccacaa tgctcttttg 4020
taccgtggtt atcatagggg tccttcacca gaactccaag gacacctcca tgcagaagac 4080
tatacctctg gtggccctca cactcacatc ttacctgggc ttgacacaac cttttttggg 4140
cctgtgtgca tttctggcaa cccgcatatt tgggcgaagg agtatcccag tgaatgaggc 4200
actcgcagca gctggtctag tgggagtgct ggcaggactg gcttttcagg agatggagaa 4260
cttccttggt ccgattgcag ttggaggaat cctgatgatg ctggttagcg tggctgggag 4320
ggtggatggg ctagagctca agaagcttgg tgaagtttca tgggaagagg aggcggagat 4380
cagcggaagt tccgcccgct atgatgtggc actcagtgaa caaggggagt tcaagctgct 4440
ttctgaagag aaagtgccat gggaccaggt tgtgatgacc tcgctggcct tggttggggc 4500
tgccattcat ccatttgctc ttctgctggt ccttgctggg tggctgtttc atgtcagggg 4560
agctaggaga agtggggatg tcttgtggga tattcccact cctaagatca ttgaggaatg 4620
tgaacatctg gaggatggga tttatggcat attccagtca accttcttgg gggcctccca 4680
gcgaggagtg ggagtggcac agggaggggt gttccacaca atgtggcatg tcacaagagg 4740
agctttcctt gtcaggaatg gcaagaagtt gattccatct tgggcttcag taaaggaaga 4800
ccttgtcgcc tatggtggct catggaagtt ggaaggcaga tgggatggag aggaagaggt 4860
ccaattgatc gctgctgttc caggaaagaa cgtggtcaac gtccagacaa aaccgagctt 4920
gttcaaagtg aggaatgggg gagaaatcgg ggctgtcgct cttgactatc cgagtggcac 4980
ttcaggatct cctattgtta acaggaacgg agaggtgatt gggctgtacg gcaatggcat 5040
ccttgtcggt gacaactcct tcgtgtccgc catatcccag actgaggtga aggaagaagg 5100
aaaggaggag ctccaagaga tcccgacaat gctaaagaaa ggaatgacaa ctatccttga 5160
ttttcatcct ggagctggga agacaagacg ttttctccca cagatcttgg ccgagtgcgc 5220
acggagacgc ttgcgcactc ttgtgttggc ccccaccagg gttgttcttt ctgaaatgaa 5280
ggaggctttt cacggcctgg acgtgaaatt ccacacacag gctttttccg ctcacggcag 5340
cgggagagaa gtcattgatg ccatgtgcca tgccacccta acttacagga tgttggaacc 5400
aactagggtt gttaactggg aagtgatcat catggatgaa gcccattttt tggatccagc 5460
tagcatagcc gccagaggtt gggcagcgca cagagctagg gcaaatgaaa gtgcaacaat 5520
cttgatgaca gccacaccgc ctgggactag tgatgaattt ccacattcaa atggtgaaat 5580
agaagatgtt caaacggaca tacccagtga gccctggaac acagggcatg actggatcct 5640
ggctgacaaa aggcccacgg catggttcct tccatccatc agagctgcaa atgtcatggc 5700
tgcctctttg cgtaaggctg gaaagagtgt ggtggtcctg aacaggaaaa cctttgagag 5760
agaatacccc acgataaagc agaagaaacc tgactttata ttggccactg acatagctga 5820
aatgggagcc aacctttgcg tggagcgagt gctggattgc aggacggctt ttaagcctgt 5880
gcttgtggat gaagggagga aggtggcaat aaaagggcca cttcgcatct ccgcatcctc 5940
tgctgctcaa aggagggggc gcattgggag aaatcccaac agagatggag actcatacta 6000
ctattctgag cccacaagtg aagataatgc ccaccacgtc tgctggttgg aggcctcaat 6060
gctcttggac aacatggagg tgaggggtgg aatggtcgcc ccactctatg gcgttgaagg 6120
aactaaaaca ccagtttccc ctggtgaaat gagactgagg gatgaccaga ggaaagtctt 6180
cagagaacta gtgaggaatt gtgacctgcc cgtttggctt tcgtggcaag tggccaaggc 6240
tggtttgaag acgaatgatc gtaagtggtg ttttgaaggc cctgaggaac atgagatctt 6300
gaatgacagc ggtgaaacag tgaagtgcag ggctcctgga ggagcaaaga agcctctgcg 6360
cccaaggtgg tgtgatgaaa gggtgtcatc tgaccagagt gcgctgtctg aatttattaa 6420
gtttgctgaa ggtaggaggg gagctgcgga agtgctagtt gtgctgagtg aactccctga 6480
tttcctggct aaaaaaggtg gagaggcaat ggataccatc agtgtgtttc tccactctga 6540
ggaaggctct agggcttacc gcaatgcact atcaatgatg cctgaggcaa tgacaatagt 6600
catgctgttt atactggctg gactactgac atcgggaatg gtcatctttt tcatgtctcc 6660
caaaggcatc agtagaatgt ctatggcgat gggcacaatg gccggctgtg gatatctcat 6720
gttccttgga ggcgtcaaac ccactcacat ctcctatatc atgctcatat tctttgtcct 6780
gatggtggtt gtgatccccg agccagggca acaaaggtcc atccaagaca accaagtggc 6840
atacctcatt attggcatcc tgacgctggt ttcagtggtg gcagccaacg agctaggcat 6900
gctggagaaa accaaagagg acctctttgg gaagaagaac ttaattccat ctagtgcttc 6960
accctggagt tggccggatc ttgacctgaa gccaggagct gcctggacag tgtacgttgg 7020
cattgttaca atgctctctc caatgttgca ccactggatc aaagtcgaat atggcaacct 7080
gtctctgtct ggaatagccc agtcagcctc agtcctttct ttcatggaca aggggatacc 7140
attcatgaag atgaatatct cggtcataat actgctggtc agtggctgga attcaataac 7200
agtgatgcct ctgctctgtg gcatagggtg cgccatgctc cactggtctc tcattttacc 7260
tggaatcaaa gcgcagcagt caaagcttgc acagagaagg gtgttccatg gcgttgccaa 7320
gaaccctgtg gttgatggga atccaacagt tgacattgag gaagctcctg aaatgcctgc 7380
cctttatgag aagaaactgg ctctatatct ccttcttgct ctcagcctag cttctgttgc 7440
catgtgcaga acgccctttt cattggctga aggcattgtc ctagcatcag ctgccttagg 7500
gccgctcata gagggaaaca ccagccttct ttggaatgga cccatggctg tctccatgac 7560
aggagtcatg cgggggaatt actatgcttt tgtgggagtc atgtacaatc tatggaagat 7620
gaaaactgga cgccggggga gtgcgaatgg aaaaactttg ggtgaagtct ggaagaggga 7680
actgaatctg ttggacaagc aacagtttga gttgtataaa aggaccgaca ttgtggaggt 7740
ggatcgtgat acggcacgca ggcatttggc cgaagggaag gtggacaccg gggtggcggt 7800
ctccaggggg accgcaaagt taaggtggtt ccatgagcgt ggctatgtca agctggaagg 7860
tagggtgatt gacctggggt gtggccgcgg aggctggtgt tactacgctg ctgcgcaaaa 7920
ggaagtgagt ggggtcaaag gatttactct tggaagagac ggccatgaga aacccatgaa 7980
tgtgcaaagt ctgggatgga acatcatcac cttcaaggac aaaactgata tccaccgcct 8040
agaaccagtg aaatgtgaca cccttttgtg tgacattgga gagtcatcat cgtcatcggt 8100
cacagagggg gaaaggaccg tgagagttct tgatactgta gaaaaatggc tggcttgtgg 8160
ggttgacaac ttctgtgtga aggtgttagc tccatacatg ccagatgttc ttgagaaact 8220
ggaattgctc caaaggaggt ttggcggaac agtgatcagg aaccctctct ccaggaattc 8280
cactcatgaa atgtactacg tgtctggagc ccgcagcaat gtcacattta ctgtgaacca 8340
aacatcccgc ctcctgatga ggagaatgag gcgtccaact ggaaaagtga ccctggaggc 8400
tgacgtcatc ctcccaattg ggacacgcag tgttgagaca gacaagggac ccctggacaa 8460
agaggccata gaagaaaggg ttgagaggat aaaatctgag tacatgacct cttggtttta 8520
tgacaatgac aacccctaca ggacctggca ctactgtggc tcctatgtca caaaaacctc 8580
aggaagtgcg gcgagcatgg taaatggtgt tattaaaatt ctgacatacc catgggacag 8640
gatagaggag gtcacaagaa tggcaatgac tgacacaacc ccttttggac agcaaagagt 8700
gtttaaagaa aaagttgaca ccagagcaaa ggatccacca gcgggaacta ggaagatcat 8760
gaaagttgtc aacaggtggc tgttccgcca cctggccaga gaaaagaacc ccagactgtg 8820
cacaaaggaa gaatttattg caaaagtccg aagtcatgca gccattggag cttacctgga 8880
agaacaagaa cagtggaaga ctgccaatga ggctgtccaa gacccaaagt tctgggaact 8940
ggtggatgaa gaaaggaagc tgcaccaaca aggcaggtgt cggacttgtg tgtacaacat 9000
gatggggaaa agagagaaga agctgtcaga gtttgggaaa gcaaagggaa gccgtgccat 9060
atggtatatg tggctgggag cgcggtatct tgagtttgag gccctgggat tcctgaatga 9120
ggaccattgg gcttccaggg aaaactcagg aggaggagtg gaaggcattg gcttacaata 9180
cctaggatat gtgatcagag acctggctgc aatggatggt ggtggattct acgcggatga 9240
caccgctgga tgggacacgc gcatcacaga ggcagacctt gatgatgaac aggagatctt 9300
gaactacatg agcccacatc acaaaaaact ggcacaagca gtgatggaaa tgacatacaa 9360
gaacaaagtg gtgaaagtgt tgagaccagc cccaggaggg aaagcctaca tggatgtcat 9420
aagtcgacga gaccagagag gatccgggca ggtagtgact tatgctctga acaccatcac 9480
caacttgaaa gtccaattga tcagaatggc agaagcagag atggtgatac atcaccaaca 9540
tgttcaagat tgtgatgaat cagttctgac caggctggag gcatggctca ctgagcacgg 9600
atgtaacaga ctgaagagga tggcggtgag tggagacgac tgtgtggtcc ggcccatcga 9660
tgacaggttc ggcctggccc tgtcccatct caacgccatg tccaaggtta gaaaggacat 9720
atctgaatgg cagccatcaa aagggtggaa tgattgggag aatgtgccct tctgttccca 9780
ccacttccat gaactacagc tgaaggatgg caggaggatt gtggtgcctt gccgagaaca 9840
ggacgagctc attgggagag gaagggtgtc tccaggaaac ggctggatga tcaaggaaac 9900
agcttgcctc agcaaagcct atgccaacat gtggtcactg atgtattttc acaaaaggga 9960
catgaggcta ctgtcattgg ctgtttcctc agctgttccc acctcatggg ttccacaagg 10020
acgcacaaca tggtcgattc atgggaaagg ggagtggatg accacggaag acatgcttga 10080
ggtgtggaac agagtatgga taaccaacaa cccacacatg caggacaaga caatggtgaa 10140
agaatggaga gatgtccctt atctaaccaa gagacaagac aagctgtgcg gatcactgat 10200
tggaatgacc aatagggcca cctgggcctc ccacatccat ttggtcatcc atcgtatccg 10260
aacgctgatt ggacaggaga aatatactga ctacctaaca gtcatggaca gatattctgt 10320
ggatgctgac ctgcaaccgg gtgagcttat ctgaaacacc atctaatagg aataaccggg 10380
atacaaacca cgggtggaga accggactcc ccacaacttg aaaccgggat ataaaccacg 10440
gctggagaac cggactccgc acaaacagaa accgggataa aaactacgga tggagaaccg 10500
gactccacac attgagacag aagaagttgt cagcccagaa ctccacacga gttttgccac 10560
tgctaagctg tgaggcagtg caggctggga cagccgacct ccaggttgcg aaaaacctgg 10620
tttctgggac ctcccacccc agagtaaaaa gaacggagcc tccgctacca ccctcccacg 10680
tggtggtaga aagacggggt ctagaggtta gaggagaccc tccagggaac aaatagtggg 10740
accatattga cgccagggaa agaccggagt ggttctctgc ttttcctcca ggggtctgtg 10800
agcacagttt gctcaagaat aagcagacct ttggatgaca aacacaaaac 10850
<210> 98
<211> 10827
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 98
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggctcgtga ggaacccctt ttttgcagtg acagctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatggac ctgctgaggc 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa gccgagttca ctgggtatgg 1500
aaaagctaca ctggaatgcc aggtgcaaac tgcggtggac tttggtaaca gttacatcgc 1560
tgagatggaa aaagagagct ggatagtgga cagacagtgg gcccaggact tgaccctgcc 1620
atggcagagt ggaagtggcg gggtgtggag agagatgcat catcttgtcg aatttgaacc 1680
tccgcatgcc gccactatca gagtactggc cctgggaaac caggaaggct ccttgaaaac 1740
agctcttacc ggcgcaatga gggttacaaa ggacacaaat gacaacaacc tttacaaact 1800
acatggtgga catgtttcct gcagagtgaa attgtcagct ttgacactca aggggacatc 1860
ctacaaaatg tgcactgaca aaatgtcttt tgtcaagaac ccaactgaca ctggccatgg 1920
cactgttgtg atgcaggtga aagtgccaaa aggagccccc tgcaagattc cagtgatagt 1980
agctgatgat cttacagcgg caatcaataa aggcattttg gttacagtta accccatcgc 2040
ctcaaccaat gatgatgaag tgctgattga ggtgaaccca ccttttggag acagctacat 2100
tatcgttggg acaggagatt cacgtctcac ttaccagtgg cacaaagagg gaagctcaat 2160
aggaaagttg ttcactcaga ccatgaaagg cgcggaacgc ctggccgtca tgggagacgc 2220
cgcctgggat ttcagctccg ctggagggtt cttcacttcg gttgggaaag gaattcatac 2280
ggtgtttggc tctgcctttc aggggctatt tggcggcttg aactggataa caaaggtcat 2340
catgggggcg gtactcatat gggttggcat caacacaaga aacatgacaa tgtccatgag 2400
catgatcttg gtaggagtga tcatgatgtt tttgtctcta ggagttgggg cggatcaagg 2460
atgcgccatc aactttggca agagagagct caagtgcgga gatggtatct tcatatttag 2520
agactctgat gactggctga acaagtactc atactatcca gaagatcctg tgaagctggc 2580
atcaatagtg aaagcctctt ttgaagaagg gaagtgtggc ctaaattcag ttgactccct 2640
tgagcatgag atgtggagaa gcagggcaga tgagatcaat gccattcttg aggaaaacga 2700
ggtggacatt tctgttgtcg tgcaggatcc aaagaatgtt taccagagag gaactcatcc 2760
attttccaga attcgggatg gtctgcagta tggttggaag acttggggta agaaccttgt 2820
gttctcccca gggaggaaga atggaagctt catcatagat ggaaagtcca ggaaagaatg 2880
cccgttttca aaccgggtct ggaattcttt ccagatagag gagtttggga cgggagtgtt 2940
caccacacgc gtgtacatgg acgcagtctt tgaatacacc atagactgcg atggatctat 3000
cttgggtgca gcggtgaacg gaaaaaagag tgcccatggc tctccaacat tttggatggg 3060
aagtcatgaa gtaaatggga catggatgat ccacaccttg gaggcattag attacaagga 3120
gtgtgagtgg ccactgacac atacgattgg aacatcagtt gaagagagtg aaatgttcat 3180
gccgagatca atcggaggcc cagttagctc tcacaatcat atccctggat acaaggttca 3240
gacgaacgga ccttggatgc aggtaccact agaggtgaag agagaagctt gcccagggac 3300
tagcgtgatc attgatggca actgtgatgg acggggaaaa tcaaccagat ccaccacgga 3360
tagcgggaaa attattcctg aatggtgttg ccgctcctgc acaatgccgc ctgtgagctt 3420
ccatggtagt gatgggtgtt ggtatcccat ggaaattagg ccaaggaaaa cgcatgaaag 3480
ccatctggtg cgctcctggg ttacagctgg agaaatacat gctgtccctt ttggtttggt 3540
gagcatgatg atagcaatgg aagtggtcct aaggaaaaga cagggaccaa agcaaatgtt 3600
ggttggagga gtggtgctct tgggagcaat gctggtcggg caagtaactc tccttgattt 3660
gctgaaactc acagtggctg tgggattgca tttccatgag atgaacaatg gaggagacgc 3720
catgtatatg gcgttgattg ctgccttttc aatcagacca gggctgctca tcggctttgg 3780
gctcaggacc ctatggagcc ctcgggaacg ccttgtgctg accctaggag cagccatggt 3840
ggagattgcc ttgggtggca tgatgggcgg cctgtggaag tatctaaatg cagtttctct 3900
ctgcatcctg acaataaatg ctgttgcttc taggaaagca tcaaatacca tcttgcccct 3960
catggctctg ttgacacctg tcactatggc tgaggtgaga cttgccacaa tgctcttttg 4020
taccgtggtt atcatagggg tccttcacca gaactccaag gacacctcca tgcagaagac 4080
tatacctctg gtggccctca cactcacatc ttacctgggc ttgacacaac cttttttggg 4140
cctgtgtgca tttctggcaa cccgcatatt tgggcgaagg agtatcccag tgaatgaggc 4200
actcgcagca gctggtctag tgggagtgct ggcaggactg gcttttcagg agatggagaa 4260
cttccttggt ccgattgcag ttggaggaat cctgatgatg ctggttagcg tggctgggag 4320
ggtggatggg ctagagctca agaagcttgg tgaagtttca tgggaagagg aggcggagat 4380
cagcggaagt tccgcccgct atgatgtggc actcagtgaa caaggggagt tcaagctgct 4440
ttctgaagag aaagtgccat gggaccaggt tgtgatgacc tcgctggcct tggttggggc 4500
tgccattcat ccatttgctc ttctgctggt ccttgctggg tggctgtttc atgtcagggg 4560
agctaggaga agtggggatg tcttgtggga tattcccact cctaagatca ttgaggaatg 4620
tgaacatctg gaggatggga tttatggcat attccagtca accttcttgg gggcctccca 4680
gcgaggagtg ggagtggcac agggaggggt gttccacaca atgtggcatg tcacaagagg 4740
agctttcctt gtcaggaatg gcaagaagtt gattccatct tgggcttcag taaaggaaga 4800
ccttgtcgcc tatggtggct catggaagtt ggaaggcaga tgggatggag aggaagaggt 4860
ccaattgatc gctgctgttc caggaaagaa cgtggtcaac gtccagacaa aaccgagctt 4920
gttcaaagtg aggaatgggg gagaaatcgg ggctgtcgct cttgactatc cgagtggcac 4980
ttcaggatct cctattgtta acaggaacgg agaggtgatt gggctgtacg gcaatggcat 5040
ccttgtcggt gacaactcct tcgtgtccgc catatcccag actgaggtga aggaagaagg 5100
aaaggaggag ctccaagaga tcccgacaat gctaaagaaa ggaatgacaa ctatccttga 5160
ttttcatcct ggagctggga agacaagacg ttttctccca cagatcttgg ccgagtgcgc 5220
acggagacgc ttgcgcactc ttgtgttggc ccccaccagg gttgttcttt ctgaaatgaa 5280
ggaggctttt cacggcctgg acgtgaaatt ccacacacag gctttttccg ctcacggcag 5340
cgggagagaa gtcattgatg ccatgtgcca tgccacccta acttacagga tgttggaacc 5400
aactagggtt gttaactggg aagtgatcat catggatgaa gcccattttt tggatccagc 5460
tagcatagcc gccagaggtt gggcagcgca cagagctagg gcaaatgaaa gtgcaacaat 5520
cttgatgaca gccacaccgc ctgggactag tgatgaattt ccacattcaa atggtgaaat 5580
agaagatgtt caaacggaca tacccagtga gccctggaac acagggcatg actggatcct 5640
ggctgacaaa aggcccacgg catggttcct tccatccatc agagctgcaa atgtcatggc 5700
tgcctctttg cgtaaggctg gaaagagtgt ggtggtcctg aacaggaaaa cctttgagag 5760
agaatacccc acgataaagc agaagaaacc tgactttata ttggccactg acatagctga 5820
aatgggagcc aacctttgcg tggagcgagt gctggattgc aggacggctt ttaagcctgt 5880
gcttgtggat gaagggagga aggtggcaat aaaagggcca cttcgcatct ccgcatcctc 5940
tgctgctcaa aggagggggc gcattgggag aaatcccaac agagatggag actcatacta 6000
ctattctgag cccacaagtg aagataatgc ccaccacgtc tgctggttgg aggcctcaat 6060
gctcttggac aacatggagg tgaggggtgg aatggtcgcc ccactctatg gcgttgaagg 6120
aactaaaaca ccagtttccc ctggtgaaat gagactgagg gatgaccaga ggaaagtctt 6180
cagagaacta gtgaggaatt gtgacctgcc cgtttggctt tcgtggcaag tggccaaggc 6240
tggtttgaag acgaatgatc gtaagtggtg ttttgaaggc cctgaggaac atgagatctt 6300
gaatgacagc ggtgaaacag tgaagtgcag ggctcctgga ggagcaaaga agcctctgcg 6360
cccaaggtgg tgtgatgaaa gggtgtcatc tgaccagagt gcgctgtctg aatttattaa 6420
gtttgctgaa ggtaggaggg gagctgcgga agtgctagtt gtgctgagtg aactccctga 6480
tttcctggct aaaaaaggtg gagaggcaat ggataccatc agtgtgtttc tccactctga 6540
ggaaggctct agggcttacc gcaatgcact atcaatgatg cctgaggcaa tgacaatagt 6600
catgctgttt atactggctg gactactgac atcgggaatg gtcatctttt tcatgtctcc 6660
caaaggcatc agtagaatgt ctatggcgat gggcacaatg gccggctgtg gatatctcat 6720
gttccttgga ggcgtcaaac ccactcacat ctcctatatc atgctcatat tctttgtcct 6780
gatggtggtt gtgatccccg agccagggca acaaaggtcc atccaagaca accaagtggc 6840
atacctcatt attggcatcc tgacgctggt ttcagtggtg gcagccaacg agctaggcat 6900
gctggagaaa accaaagagg acctctttgg gaagaagaac ttaattccat ctagtgcttc 6960
accctggagt tggccggatc ttgacctgaa gccaggagct gcctggacag tgtacgttgg 7020
cattgttaca atgctctctc caatgttgca ccactggatc aaagtcgaat atggcaacct 7080
gtctctgtct ggaatagccc agtcagcctc agtcctttct ttcatggaca aggggatacc 7140
attcatgaag atgaatatct cggtcataat actgctggtc agtggctgga attcaataac 7200
agtgatgcct ctgctctgtg gcatagggtg cgccatgctc cactggtctc tcattttacc 7260
tggaatcaaa gcgcagcagt caaagcttgc acagagaagg gtgttccatg gcgttgccaa 7320
gaaccctgtg gttgatggga atccaacagt tgacattgag gaagctcctg aaatgcctgc 7380
cctttatgag aagaaactgg ctctatatct ccttcttgct ctcagcctag cttctgttgc 7440
catgtgcaga acgccctttt cattggctga aggcattgtc ctagcatcag ctgccttagg 7500
gccgctcata gagggaaaca ccagccttct ttggaatgga cccatggctg tctccatgac 7560
aggagtcatg cgggggaatt actatgcttt tgtgggagtc atgtacaatc tatggaagat 7620
gaaaactgga cgccggggga gtgcgaatgg aaaaactttg ggtgaagtct ggaagaggga 7680
actgaatctg ttggacaagc aacagtttga gttgtataaa aggaccgaca ttgtggaggt 7740
ggatcgtgat acggcacgca ggcatttggc cgaagggaag gtggacaccg gggtggcggt 7800
ctccaggggg accgcaaagt taaggtggtt ccatgagcgt ggctatgtca agctggaagg 7860
tagggtgatt gacctggggt gtggccgcgg aggctggtgt tactacgctg ctgcgcaaaa 7920
ggaagtgagt ggggtcaaag gatttactct tggaagagac ggccatgaga aacccatgaa 7980
tgtgcaaagt ctgggatgga acatcatcac cttcaaggac aaaactgata tccaccgcct 8040
agaaccagtg aaatgtgaca cccttttgtg tgacattgga gagtcatcat cgtcatcggt 8100
cacagagggg gaaaggaccg tgagagttct tgatactgta gaaaaatggc tggcttgtgg 8160
ggttgacaac ttctgtgtga aggtgttagc tccatacatg ccagatgttc ttgagaaact 8220
ggaattgctc caaaggaggt ttggcggaac agtgatcagg aaccctctct ccaggaattc 8280
cactcatgaa atgtactacg tgtctggagc ccgcagcaat gtcacattta ctgtgaacca 8340
aacatcccgc ctcctgatga ggagaatgag gcgtccaact ggaaaagtga ccctggaggc 8400
tgacgtcatc ctcccaattg ggacacgcag tgttgagaca gacaagggac ccctggacaa 8460
agaggccata gaagaaaggg ttgagaggat aaaatctgag tacatgacct cttggtttta 8520
tgacaatgac aacccctaca ggacctggca ctactgtggc tcctatgtca caaaaacctc 8580
aggaagtgcg gcgagcatgg taaatggtgt tattaaaatt ctgacatacc catgggacag 8640
gatagaggag gtcacaagaa tggcaatgac tgacacaacc ccttttggac agcaaagagt 8700
gtttaaagaa aaagttgaca ccagagcaaa ggatccacca gcgggaacta ggaagatcat 8760
gaaagttgtc aacaggtggc tgttccgcca cctggccaga gaaaagaacc ccagactgtg 8820
cacaaaggaa gaatttattg caaaagtccg aagtcatgca gccattggag cttacctgga 8880
agaacaagaa cagtggaaga ctgccaatga ggctgtccaa gacccaaagt tctgggaact 8940
ggtggatgaa gaaaggaagc tgcaccaaca aggcaggtgt cggacttgtg tgtacaacat 9000
gatggggaaa agagagaaga agctgtcaga gtttgggaaa gcaaagggaa gccgtgccat 9060
atggtatatg tggctgggag cgcggtatct tgagtttgag gccctgggat tcctgaatga 9120
ggaccattgg gcttccaggg aaaactcagg aggaggagtg gaaggcattg gcttacaata 9180
cctaggatat gtgatcagag acctggctgc aatggatggt ggtggattct acgcggatga 9240
caccgctgga tgggacacgc gcatcacaga ggcagacctt gatgatgaac aggagatctt 9300
gaactacatg agcccacatc acaaaaaact ggcacaagca gtgatggaaa tgacatacaa 9360
gaacaaagtg gtgaaagtgt tgagaccagc cccaggaggg aaagcctaca tggatgtcat 9420
aagtcgacga gaccagagag gatccgggca ggtagtgact tatgctctga acaccatcac 9480
caacttgaaa gtccaattga tcagaatggc agaagcagag atggtgatac atcaccaaca 9540
tgttcaagat tgtgatgaat cagttctgac caggctggag gcatggctca ctgagcacgg 9600
atgtaacaga ctgaagagga tggcggtgag tggagacgac tgtgtggtcc ggcccatcga 9660
tgacaggttc ggcctggccc tgtcccatct caacgccatg tccaaggtta gaaaggacat 9720
atctgaatgg cagccatcaa aagggtggaa tgattgggag aatgtgccct tctgttccca 9780
ccacttccat gaactacagc tgaaggatgg caggaggatt gtggtgcctt gccgagaaca 9840
ggacgagctc attgggagag gaagggtgtc tccaggaaac ggctggatga tcaaggaaac 9900
agcttgcctc agcaaagcct atgccaacat gtggtcactg atgtattttc acaaaaggga 9960
catgaggcta ctgtcattgg ctgtttcctc agctgttccc acctcatggg ttccacaagg 10020
acgcacaaca tggtcgattc atgggaaagg ggagtggatg accacggaag acatgcttga 10080
ggtgtggaac agagtatgga taaccaacaa cccacacatg caggacaaga caatggtgaa 10140
agaatggaga gatgtccctt atctaaccaa gagacaagac aagctgtgcg gatcactgat 10200
tggaatgacc aatagggcca cctgggcctc ccacatccat ttggtcatcc atcgtatccg 10260
aacgctgatt ggacaggaga aatatactga ctacctaaca gtcatggaca gatattctgt 10320
ggatgctgac ctgcaaccgg gtgagcttat ctgaaacacc atctaatagg aataaccggg 10380
atacaaacca cgggtggaga accggactcc ccacaacttg aaaccgggat ataaaccacg 10440
gctggagaac cggactccgc acttaaaatg aaacagaaac cgggataaaa actacagaag 10500
aagttgtcag cccagaactc cacacgagtt ttgccactgc taagctgtga ggcagtgcag 10560
gctgggacag ccgacctcca ggttgcgaaa aacctggttt ctgggacctc ccaccccaga 10620
gtaaaaagaa cggagcctcc gctaccaccc tcccacgtgg tggtagaaag acggggtcta 10680
gaggttagag gagaccctcc agggaacaaa tagtgggacc atattgacgc cagggaaaga 10740
ccggagtggt tctctgcttt tcctccaggg gtctgtgagc acagtttgct caagaataag 10800
cagacctttg gatgacaaac acaaaac 10827
<210> 99
<211> 8070
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 99
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttaaat gggacatgga tgatccacac 300
cttggaggca ttagattaca aggagtgtga gtggccactg acacatacga ttggaacatc 360
agttgaagag agtgaaatgt tcatgccgag atcaatcgga ggcccagtta gctctcacaa 420
tcatatccct ggatacaagg ttcagacgaa cggaccttgg atgcaggtac cactagaagt 480
gaagagagaa gcttgcccag ggactagcgt gatcattgat ggcaactgtg atggacgggg 540
aaaatcaacc agatccacca cggatagcgg gaaagttatt cctgaatggt gttgccgctc 600
ctgcacaatg ccgcctgtga gcttccatgg tagtgatggg tgttggtatc ccatggaaat 660
taggccaagg aaaacgcatg aaagccatct ggtgcgctcc tgggttacag ctggagaaat 720
acatgctgtc ccttttggtt tggtgagcat gatgatagca atggaagtgg tcctaaggaa 780
aagacaggga ccaaagcaaa tgttggttgg aggagtagtg ctcttgggag caatgctggt 840
cgggcaagta actctccttg atttgctgaa actcacagtg gctgtgggat tgcatttcca 900
tgagatgaac aatggaggag acgccatgta tatggcgttg attgctgcct tttcaatcag 960
accagggctg ctcatcggct ttgggctcag gaccctatgg agccctcggg aacgccttgt 1020
gctgacccta ggagcagcca tggtggagat tgccttgggt ggcgtgatgg gcggcctgtg 1080
gaagtatcta aatgcagttt ctctctgcat cctgacaata aatgctgttg cttctaggaa 1140
agcatcaaat accatcttgc ccctcatggc tctgttgaca cctgtcacta tggctgaggt 1200
gagacttgcc gcaatgttct tttgtgccat ggttatcata ggggtccttc accagaattt 1260
caaggacacc tccatgcaga agactatacc tctggtggcc ctcacactca catcttacct 1320
gggcttgaca caaccttttt tgggcctgtg tgcatttctg gcaacccgca tatttgggcg 1380
aaggagtatc ccagtgaatg aggcactcgc agcagctggt ctagtgggag tgctggcagg 1440
actggctttt caggagatgg agaacttcct tggtccgatt gcagttggag gactcctgat 1500
gatgctggtt agcgtggctg ggagggtgga tgggctagag ctcaagaagc ttggtgaagt 1560
ttcatgggaa gaggaggcgg agatcagcgg gagttccgcc cgctatgatg tggcactcag 1620
tgaacaaggg gagttcaagc tgctttctga agagaaagtg ccatgggacc aggttgtgat 1680
gacctcgctg gccttggttg gggctgccct ccatccattt gctcttctgc tggtccttgc 1740
tgggtggctg tttcatgtca ggggagctag gagaagtggg gatgtcttgt gggatattcc 1800
cactcctaag atcatcgagg aatgtgaaca tctggaggat gggatttatg gcatattcca 1860
gtcaaccttc ttgggggcct cccagcgagg agtgggagtg gcacagggag gggtgttcca 1920
cacaatgtgg catgtcacaa gaggagcttt ccttgtcagg aatggcaaga agttgattcc 1980
atcttgggct tcagtaaagg aagaccttgt cgcctatggt ggctcatgga agttggaagg 2040
cagatgggat ggagaggaag aggtccagtt gatcgcggct gttccaggaa agaacgtggt 2100
caacgtccag acaaaaccga gcttgttcaa agtgaggaat gggggagaaa tcggggctgt 2160
cgctcttgac tatccgagtg gcacttcagg atctcctatt gttaacagga acggagaggt 2220
gattgggctg tacggcaatg gcatccttgt cggtgacaac tccttcgtgt ccgccatatc 2280
ccagactgag gtgaaggaag aaggaaagga ggagctccaa gagatcccga caatgctaaa 2340
gaaaggaatg acaactgtcc ttgattttca tcctggagct gggaagacaa gacgtttcct 2400
cccacagatc ttggccgagt gcgcacggag acgcttgcgc actcttgtgt tggcccccac 2460
cagggttgtt ctttctgaaa tgaaggaggc ttttcacggc ctggacgtga aattccacac 2520
acaggctttt tccgctcacg gcagcgggag agaagtcatt gatgccatgt gccatgccac 2580
cctaacttac aggatgttgg aaccaactag ggttgttaac tgggaagtga tcattatgga 2640
tgaagcccat tttttggatc cagctagcat agccgctaga ggttgggcag cgcacagagc 2700
tagggcaaat gaaagtgcaa caatcttgat gacagccaca ccgcctggga ctagtgatga 2760
atttccacat tcaaatggtg aaatagaaga tgttcaaacg gacataccca gtgagccctg 2820
gaacacaggg catgactgga tcctggctga caaaaggccc acggcatggt tccttccatc 2880
catcagagct gcaaatgtca tggctgcctc tttgcgtaag gctggaaaga gtgtggtggt 2940
cctgaacagg aaaacctttg agagagaata ccccacgata aagcagaaga aacctgactt 3000
tatattggcc actgacatag ctgaaatggg agccaacctt tgcgtggagc gagtgctgga 3060
ttgcaggacg gcttttaagc ctgtgcttgt ggatgaaggg aggaaggtgg caataaaagg 3120
gccacttcgt atctccgcat cctctgctgc tcaaaggagg gggcgcattg ggagaaatcc 3180
caacagagat ggagactcat actactattc tgagcctaca agtgaaaata atgcccacca 3240
cgtctgctgg ttggaggcct caatgctctt ggacaacatg gaggtgaggg gtggaatggt 3300
cgccccactc tatggcgttg aaggaactaa aacaccagtt tcccctggtg aaatgagact 3360
gagggatgac cagaggaaag tcttcagaga actagtgagg aattgtgacc tgcccgtttg 3420
gctttcgtgg caagtggcca aggctggttt gaagacgaat gatcgtaagt ggtgttttga 3480
aggccctgag gaacatgaga tcttgaatga cagcggtgaa acagtgaagt gcagggctcc 3540
tggaggagca aagaagcctc tgcgcccaag gtggtgtgat gaaagggtgt catctgacca 3600
gagtgcgctg tctgaattta ttaagtttgc tgaaggtagg aggggagctg ctgaagtgct 3660
agttgtgctg agtgaactcc ctgatttcct ggctaaaaaa ggtggagagg caatggatac 3720
catcagtgtg ttcctccact ctgaggaagg ctctagggct taccgcaatg cactatcaat 3780
gatgcctgag gcaatgacaa tagtcatgct gtttatactg gctggactac tgacatcggg 3840
aatggtcatc tttttcatgt ctcccaaagg catcagtaga atgtctatgg cgatgggcac 3900
aatggccggc tgtggatatc tcatgttcct tggaggcgtc aaacccactc acatctccta 3960
tgtcatgctc atattctttg tcctgatggt ggttgtgatc cccgagccag ggcaacaaag 4020
gtccatccaa gacaaccaag tggcatacct cattattggc atcctgacgc tggtttcagc 4080
ggtggcagcc aacgagctag gcatgctgga gaaaaccaaa gaggacctct ttgggaagaa 4140
gaacttaatt ccatctagtg cttcaccctg gagttggccg gatcttgacc tgaagccagg 4200
agctgcctgg acagtgtacg ttggcattgt tacaatgctc tctccaatgt tgcaccactg 4260
gatcaaagtc gaatatggca acctgtctct gtctggaata gcccagtcag cctcagtcct 4320
ttctttcatg gacaagggga taccattcat gaagatgaat atctcggtca taatgctgct 4380
ggtcagtggc tggaattcaa taacagtgat gcctctgctc tgtggcatag ggtgcgccat 4440
gctccactgg tctctcattt tacctggaat caaagcgcag cagtcaaagc ttgcacagag 4500
aagggtgttc catggcgttg ccaagaaccc tgtggttgat gggaatccaa cagttgacat 4560
tgaggaagct cctgaaatgc ctgcccttta tgagaagaaa ctggctctat atctccttct 4620
tgctctcagc ctagcttctg ttgccatgtg cagaacgccc ttttcattgg ctgaaggcat 4680
tgtcctagca tcagctgcct tagggccgct catagaggga aacaccagcc ttctttggaa 4740
tggacccatg gctgtctcca tgacaggagt catgaggggg aatcactatg cttttgtggg 4800
agtcatgtac aatctatgga agatgaaaac tggacgccgg gggagcgcga atggaaaaac 4860
tttgggtgaa gtctggaaga gggaactgaa tctgttggac aagcgacagt ttgagttgta 4920
taaaaggacc gacattgtgg aggtggatcg tgatacggca cgcaggcatt tggccgaagg 4980
gaaggtggac accggggtgg cggtctccag ggggaccgca aagttaaggt ggttccatga 5040
gcgtggctat gtcaagctgg aaggtagggt gattgacctg gggtgtggcc gcggaggctg 5100
gtgttactac gctgctgcgc aaaaggaagt gagtggggtc aaaggattta ctcttggaag 5160
agacggccat gagaaaccca tgaatgtgca aagtctggga tggaacatca tcaccttcaa 5220
ggacaaaact gatatccacc gcctagaacc agtgaaatgt gacacccttt tgtgtgacat 5280
tggagagtca tcatcgtcat cggtcacaga gggggaaagg accgtgagag ttcttgatac 5340
tgtagaaaaa tggctggctt gtggggttga caacttctgt gtgaaggtgt tagctccata 5400
catgccagat gttcttgaga aactggaatt gctccaaagg aggtttggcg gaacagtgat 5460
caggaaccct ctctccagga attccactca tgaaatgtac tacgtgtctg gagcccgcag 5520
caatgtcaca tttactgtga accaaacatc ccgcctcctg atgaggagaa tgaggcgtcc 5580
aactggaaaa gtgaccctgg aggctgacgt catcctccca attgggacac gcagtgttga 5640
gacagacaag ggacccctgg acaaagaggc catagaagaa agggttgaga ggataaaatc 5700
tgagtacatg acctcttggt tttatgacaa tgacaacccc tacaggacct ggcactactg 5760
tggctcctat gtcacaaaaa cctcaggaag tgcggcgagc atggtaaatg gtgttattaa 5820
aattctgaca tatccatggg acaggataga ggaggtcaca agaatggcaa tgactgacac 5880
aacccctttt ggacagcaaa gagtgtttaa agaaaaagtt gacaccagag caaaggatcc 5940
accagcggga actaggaaga tcatgaaagt tgtcaacagg tggctgttcc gccacctggc 6000
cagagaaaag aaccccagac tgtgcacaaa ggaagaattt attgcaaaag tccgaagtca 6060
tgcagccatt ggagcttacc tggaagaaca agaacagtgg aagactgcca atgaggctgt 6120
ccaagaccca aagttctggg aactggtgga tgaagaaagg aagctgcacc aacaaggcag 6180
gtgtcggact tgtgtgtaca acatgatggg gaaaagagag aagaagctgt cagagtttgg 6240
gaaagcaaag ggaagccgtg ccatatggta tatgtggctg ggagcgcggt atcttgagtt 6300
tgaggccctg ggattcctga atgaggacca ttgggcttcc agggaaaact caggaggagg 6360
agtggaaggc attggcttac aatacctagg atatgtgatc agagacctgg ctgcaatgga 6420
tggtggtgga ttctacgcgg atgacaccgc tggatgggac acgcgcatca cagaggcaga 6480
ccttgatgat gaacaggaga tcttgaacta catgagccca catcacaaaa aactggcaca 6540
agcagtgatg gaaatgacat acaagaacaa agtggtgaaa gtgttgagac cagccccagg 6600
agggaaagcc tacatggatg tcataagtcg acgagaccag agaggatccg ggcaggtagt 6660
gacttatgct ctgaacacca tcaccaactt gaaagtccaa ttgatcagaa tggcagaagc 6720
agagatggtg atacatcacc aacatgttca agattgtgat gaatcagttc tgaccaggct 6780
ggaggcatgg ctcactgagc acggatgtga cagactgaag aggatggcgg tgagtggaga 6840
cgactgtgtg gtccggccca tcgatgacag gttcggcctg gccctgtccc atctcaacgc 6900
catgtccaag gttagaaagg acatatctga atggcagcca tcaaaagggt ggaatgattg 6960
ggagaatgtg cccttctgtt cccaccactt ccatgaacta cagctgaagg atggcaggag 7020
gattgtggtg ccttgccgag aacaggacga gctcattggg agaggaaggg tgtctccagg 7080
aaacggctgg atgatcaagg aaacagcttg cctcagcaaa gcctatgcca acatgtggtc 7140
actgatgtat tttcacaaaa gggacatgag gctactgtca ttggctgttt cctcagctgt 7200
tcccacctca tgggttccac aaggacgcac aacatggtcg attcatggga aaggggagtg 7260
gatgaccacg gaagacatgc ttgaggtgtg gaacagagta tggataacca acaacccaca 7320
catgcaggac aagacaatgg tgaaaaaatg gagagatgtc ccttatctaa ccaagagaca 7380
agacaagctg tgcggatcac tgattggaat gaccaatagg gccacctggg cctcccacat 7440
ccatttagtc atccatcgta tccgaacgct gattggacag gagaaataca ctgactacct 7500
aacagtcatg gacaggtatt ctgtggatgc tgacctgcaa ctgggtgagc ttatctgaaa 7560
caccatctaa caggaataac cgggatacaa accacgggtg gagaaccgga ctccccacaa 7620
cctgaaaccg ggatataaac cacggctgga gaaccggact ccgcacttaa aatgaaacag 7680
aaaccgggat aaaaactacg gatggagaac cggactccac acattgagac agaagaagtt 7740
gtcagcccag aaccccacac gagttttgcc actgctaagc tgtgaggcag tgcaggctgg 7800
gacagccgac ctccaggttg cgaaaaacct ggtttctggg acctcccacc ccagagtaaa 7860
aagaacggag cctccgctac caccctccca cgtggtggta gaaagacggg gtctagaggt 7920
tagaggagac cctccaggga acaaatagtg ggaccatatt gacgccaggg aaagaccgga 7980
gtggttctct gcttttcctc cagaggtctg tgagcacagt ttgctcaaga ataagcagac 8040
ctttggatga caaacacaaa accactcgag 8070
<210> 100
<211> 8142
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 100
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagata ttcctgaatg 660
gtgttgccgc tcctgcacaa tgccgcctgt gagcttccat ggtagtgatg ggtgttggta 720
tcccatggaa attaggccaa ggaaaacgca tgaaagccat ctggtgcgct cctgggttac 780
agctggagaa atacatgctg tcccttttgg tttggtgagc atgatgatag caatggaagt 840
ggtcctaagg aaaagacagg gaccaaagca aatgttggtt ggaggagtag tgctcttggg 900
agcaatgctg gtcgggcaag taactctcct tgatttgctg aaactcacag tggctgtggg 960
attgcatttc catgagatga acaatggagg agacgccatg tatatggcgt tgattgctgc 1020
cttttcaatc agaccagggc tgctcatcgg ctttgggctc aggaccctat ggagccctcg 1080
ggaacgcctt gtgctgaccc taggagcagc catggtggag attgccttgg gtggcgtgat 1140
gggcggcctg tggaagtatc taaatgcagt ttctctctgc atcctgacaa taaatgctgt 1200
tgcttctagg aaagcatcaa ataccatctt gcccctcatg gctctgttga cacctgtcac 1260
tatggctgag gtgagacttg ccgcaatgtt cttttgtgcc atggttatca taggggtcct 1320
tcaccagaat ttcaaggaca cctccatgca gaagactata cctctggtgg ccctcacact 1380
cacatcttac ctgggcttga cacaaccttt tttgggcctg tgtgcatttc tggcaacccg 1440
catatttggg cgaaggagta tcccagtgaa tgaggcactc gcagcagctg gtctagtggg 1500
agtgctggca ggactggctt ttcaggagat ggagaacttc cttggtccga ttgcagttgg 1560
aggactcctg atgatgctgg ttagcgtggc tgggagggtg gatgggctag agctcaagaa 1620
gcttggtgaa gtttcatggg aagaggaggc ggagatcagc gggagttccg cccgctatga 1680
tgtggcactc agtgaacaag gggagttcaa gctgctttct gaagagaaag tgccatggga 1740
ccaggttgtg atgacctcgc tggccttggt tggggctgcc ctccatccat ttgctcttct 1800
gctggtcctt gctgggtggc tgtttcatgt caggggagct aggagaagtg gggatgtctt 1860
gtgggatatt cccactccta agatcatcga ggaatgtgaa catctggagg atgggattta 1920
tggcatattc cagtcaacct tcttgggggc ctcccagcga ggagtgggag tggcacaggg 1980
aggggtgttc cacacaatgt ggcatgtcac aagaggagct ttccttgtca ggaatggcaa 2040
gaagttgatt ccatcttggg cttcagtaaa ggaagacctt gtcgcctatg gtggctcatg 2100
gaagttggaa ggcagatggg atggagagga agaggtccag ttgatcgcgg ctgttccagg 2160
aaagaacgtg gtcaacgtcc agacaaaacc gagcttgttc aaagtgagga atgggggaga 2220
aatcggggct gtcgctcttg actatccgag tggcacttca ggatctccta ttgttaacag 2280
gaacggagag gtgattgggc tgtacggcaa tggcatcctt gtcggtgaca actccttcgt 2340
gtccgccata tcccagactg aggtgaagga agaaggaaag gaggagctcc aagagatccc 2400
gacaatgcta aagaaaggaa tgacaactgt ccttgatttt catcctggag ctgggaagac 2460
aagacgtttc ctcccacaga tcttggccga gtgcgcacgg agacgcttgc gcactcttgt 2520
gttggccccc accagggttg ttctttctga aatgaaggag gcttttcacg gcctggacgt 2580
gaaattccac acacaggctt tttccgctca cggcagcggg agagaagtca ttgatgccat 2640
gtgccatgcc accctaactt acaggatgtt ggaaccaact agggttgtta actgggaagt 2700
gatcattatg gatgaagccc attttttgga tccagctagc atagccgcta gaggttgggc 2760
agcgcacaga gctagggcaa atgaaagtgc aacaatcttg atgacagcca caccgcctgg 2820
gactagtgat gaatttccac attcaaatgg tgaaatagaa gatgttcaaa cggacatacc 2880
cagtgagccc tggaacacag ggcatgactg gatcctggct gacaaaaggc ccacggcatg 2940
gttccttcca tccatcagag ctgcaaatgt catggctgcc tctttgcgta aggctggaaa 3000
gagtgtggtg gtcctgaaca ggaaaacctt tgagagagaa taccccacga taaagcagaa 3060
gaaacctgac tttatattgg ccactgacat agctgaaatg ggagccaacc tttgcgtgga 3120
gcgagtgctg gattgcagga cggcttttaa gcctgtgctt gtggatgaag ggaggaaggt 3180
ggcaataaaa gggccacttc gtatctccgc atcctctgct gctcaaagga gggggcgcat 3240
tgggagaaat cccaacagag atggagactc atactactat tctgagccta caagtgaaaa 3300
taatgcccac cacgtctgct ggttggaggc ctcaatgctc ttggacaaca tggaggtgag 3360
gggtggaatg gtcgccccac tctatggcgt tgaaggaact aaaacaccag tttcccctgg 3420
tgaaatgaga ctgagggatg accagaggaa agtcttcaga gaactagtga ggaattgtga 3480
cctgcccgtt tggctttcgt ggcaagtggc caaggctggt ttgaagacga atgatcgtaa 3540
gtggtgtttt gaaggccctg aggaacatga gatcttgaat gacagcggtg aaacagtgaa 3600
gtgcagggct cctggaggag caaagaagcc tctgcgccca aggtggtgtg atgaaagggt 3660
gtcatctgac cagagtgcgc tgtctgaatt tattaagttt gctgaaggta ggaggggagc 3720
tgctgaagtg ctagttgtgc tgagtgaact ccctgatttc ctggctaaaa aaggtggaga 3780
ggcaatggat accatcagtg tgttcctcca ctctgaggaa ggctctaggg cttaccgcaa 3840
tgcactatca atgatgcctg aggcaatgac aatagtcatg ctgtttatac tggctggact 3900
actgacatcg ggaatggtca tctttttcat gtctcccaaa ggcatcagta gaatgtctat 3960
ggcgatgggc acaatggccg gctgtggata tctcatgttc cttggaggcg tcaaacccac 4020
tcacatctcc tatgtcatgc tcatattctt tgtcctgatg gtggttgtga tccccgagcc 4080
agggcaacaa aggtccatcc aagacaacca agtggcatac ctcattattg gcatcctgac 4140
gctggtttca gcggtggcag ccaacgagct aggcatgctg gagaaaacca aagaggacct 4200
ctttgggaag aagaacttaa ttccatctag tgcttcaccc tggagttggc cggatcttga 4260
cctgaagcca ggagctgcct ggacagtgta cgttggcatt gttacaatgc tctctccaat 4320
gttgcaccac tggatcaaag tcgaatatgg caacctgtct ctgtctggaa tagcccagtc 4380
agcctcagtc ctttctttca tggacaaggg gataccattc atgaagatga atatctcggt 4440
cataatgctg ctggtcagtg gctggaattc aataacagtg atgcctctgc tctgtggcat 4500
agggtgcgcc atgctccact ggtctctcat tttacctgga atcaaagcgc agcagtcaaa 4560
gcttgcacag agaagggtgt tccatggcgt tgccaagaac cctgtggttg atgggaatcc 4620
aacagttgac attgaggaag ctcctgaaat gcctgccctt tatgagaaga aactggctct 4680
atatctcctt cttgctctca gcctagcttc tgttgccatg tgcagaacgc ccttttcatt 4740
ggctgaaggc attgtcctag catcagctgc cttagggccg ctcatagagg gaaacaccag 4800
ccttctttgg aatggaccca tggctgtctc catgacagga gtcatgaggg ggaatcacta 4860
tgcttttgtg ggagtcatgt acaatctatg gaagatgaaa actggacgcc gggggagcgc 4920
gaatggaaaa actttgggtg aagtctggaa gagggaactg aatctgttgg acaagcgaca 4980
gtttgagttg tataaaagga ccgacattgt ggaggtggat cgtgatacgg cacgcaggca 5040
tttggccgaa gggaaggtgg acaccggggt ggcggtctcc agggggaccg caaagttaag 5100
gtggttccat gagcgtggct atgtcaagct ggaaggtagg gtgattgacc tggggtgtgg 5160
ccgcggaggc tggtgttact acgctgctgc gcaaaaggaa gtgagtgggg tcaaaggatt 5220
tactcttgga agagacggcc atgagaaacc catgaatgtg caaagtctgg gatggaacat 5280
catcaccttc aaggacaaaa ctgatatcca ccgcctagaa ccagtgaaat gtgacaccct 5340
tttgtgtgac attggagagt catcatcgtc atcggtcaca gagggggaaa ggaccgtgag 5400
agttcttgat actgtagaaa aatggctggc ttgtggggtt gacaacttct gtgtgaaggt 5460
gttagctcca tacatgccag atgttcttga gaaactggaa ttgctccaaa ggaggtttgg 5520
cggaacagtg atcaggaacc ctctctccag gaattccact catgaaatgt actacgtgtc 5580
tggagcccgc agcaatgtca catttactgt gaaccaaaca tcccgcctcc tgatgaggag 5640
aatgaggcgt ccaactggaa aagtgaccct ggaggctgac gtcatcctcc caattgggac 5700
acgcagtgtt gagacagaca agggacccct ggacaaagag gccatagaag aaagggttga 5760
gaggataaaa tctgagtaca tgacctcttg gttttatgac aatgacaacc cctacaggac 5820
ctggcactac tgtggctcct atgtcacaaa aacctcagga agtgcggcga gcatggtaaa 5880
tggtgttatt aaaattctga catatccatg ggacaggata gaggaggtca caagaatggc 5940
aatgactgac acaacccctt ttggacagca aagagtgttt aaagaaaaag ttgacaccag 6000
agcaaaggat ccaccagcgg gaactaggaa gatcatgaaa gttgtcaaca ggtggctgtt 6060
ccgccacctg gccagagaaa agaaccccag actgtgcaca aaggaagaat ttattgcaaa 6120
agtccgaagt catgcagcca ttggagctta cctggaagaa caagaacagt ggaagactgc 6180
caatgaggct gtccaagacc caaagttctg ggaactggtg gatgaagaaa ggaagctgca 6240
ccaacaaggc aggtgtcgga cttgtgtgta caacatgatg gggaaaagag agaagaagct 6300
gtcagagttt gggaaagcaa agggaagccg tgccatatgg tatatgtggc tgggagcgcg 6360
gtatcttgag tttgaggccc tgggattcct gaatgaggac cattgggctt ccagggaaaa 6420
ctcaggagga ggagtggaag gcattggctt acaataccta ggatatgtga tcagagacct 6480
ggctgcaatg gatggtggtg gattctacgc ggatgacacc gctggatggg acacgcgcat 6540
cacagaggca gaccttgatg atgaacagga gatcttgaac tacatgagcc cacatcacaa 6600
aaaactggca caagcagtga tggaaatgac atacaagaac aaagtggtga aagtgttgag 6660
accagcccca ggagggaaag cctacatgga tgtcataagt cgacgagacc agagaggatc 6720
cgggcaggta gtgacttatg ctctgaacac catcaccaac ttgaaagtcc aattgatcag 6780
aatggcagaa gcagagatgg tgatacatca ccaacatgtt caagattgtg atgaatcagt 6840
tctgaccagg ctggaggcat ggctcactga gcacggatgt gacagactga agaggatggc 6900
ggtgagtgga gacgactgtg tggtccggcc catcgatgac aggttcggcc tggccctgtc 6960
ccatctcaac gccatgtcca aggttagaaa ggacatatct gaatggcagc catcaaaagg 7020
gtggaatgat tgggagaatg tgcccttctg ttcccaccac ttccatgaac tacagctgaa 7080
ggatggcagg aggattgtgg tgccttgccg agaacaggac gagctcattg ggagaggaag 7140
ggtgtctcca ggaaacggct ggatgatcaa ggaaacagct tgcctcagca aagcctatgc 7200
caacatgtgg tcactgatgt attttcacaa aagggacatg aggctactgt cattggctgt 7260
ttcctcagct gttcccacct catgggttcc acaaggacgc acaacatggt cgattcatgg 7320
gaaaggggag tggatgacca cggaagacat gcttgaggtg tggaacagag tatggataac 7380
caacaaccca cacatgcagg acaagacaat ggtgaaaaaa tggagagatg tcccttatct 7440
aaccaagaga caagacaagc tgtgcggatc actgattgga atgaccaata gggccacctg 7500
ggcctcccac atccatttag tcatccatcg tatccgaacg ctgattggac aggagaaata 7560
cactgactac ctaacagtca tggacaggta ttctgtggat gctgacctgc aactgggtga 7620
gcttatctga aacaccatct aacaggaata accgggatac aaaccacggg tggagaaccg 7680
gactccccac aacctgaaac cgggatataa accacggctg gagaaccgga ctccgcactt 7740
aaaatgaaac agaaaccggg ataaaaacta cggatggaga accggactcc acacattgag 7800
acagaagaag ttgtcagccc agaaccccac acgagttttg ccactgctaa gctgtgaggc 7860
agtgcaggct gggacagccg acctccaggt tgcgaaaaac ctggtttctg ggacctccca 7920
ccccagagta aaaagaacgg agcctccgct accaccctcc cacgtggtgg tagaaagacg 7980
gggtctagag gttagaggag accctccagg gaacaaatag tgggaccata ttgacgccag 8040
ggaaagaccg gagtggttct ctgcttttcc tccagaggtc tgtgagcaca gtttgctcaa 8100
gaataagcag acctttggat gacaaacaca aaaccactcg ag 8142
<210> 101
<211> 8718
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 101
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aagagtttgg 780
gacgggagtg ttcaccacac gcgtgtacat ggacgcagtc tttgaataca ccatagactg 840
cgatggatct atcttgggtg cagcggtgaa cggaaaaaag agtgcccatg gctctccaac 900
attttggatg ggaagtcatg aagtaaatgg gacatggatg atccacacct tggaggcatt 960
agattacaag gagtgtgagt ggccactgac acatacgatt ggaacatcag ttgaagagag 1020
tgaaatgttc atgccgagat caatcggagg cccagttagc tctcacaatc atatccctgg 1080
atacaaggtt cagacgaacg gaccttggat gcaggtacca ctagaagtga agagagaagc 1140
ttgcccaggg actagcgtga tcattgatgg caactgtgat ggacggggaa aatcaaccag 1200
atccaccacg gatagcggga aagttattcc tgaatggtgt tgccgctcct gcacaatgcc 1260
gcctgtgagc ttccatggta gtgatgggtg ttggtatccc atggaaatta ggccaaggaa 1320
aacgcatgaa agccatctgg tgcgctcctg ggttacagct ggagaaatac atgctgtccc 1380
ttttggtttg gtgagcatga tgatagcaat ggaagtggtc ctaaggaaaa gacagggacc 1440
aaagcaaatg ttggttggag gagtagtgct cttgggagca atgctggtcg ggcaagtaac 1500
tctccttgat ttgctgaaac tcacagtggc tgtgggattg catttccatg agatgaacaa 1560
tggaggagac gccatgtata tggcgttgat tgctgccttt tcaatcagac cagggctgct 1620
catcggcttt gggctcagga ccctatggag ccctcgggaa cgccttgtgc tgaccctagg 1680
agcagccatg gtggagattg ccttgggtgg cgtgatgggc ggcctgtgga agtatctaaa 1740
tgcagtttct ctctgcatcc tgacaataaa tgctgttgct tctaggaaag catcaaatac 1800
catcttgccc ctcatggctc tgttgacacc tgtcactatg gctgaggtga gacttgccgc 1860
aatgttcttt tgtgccatgg ttatcatagg ggtccttcac cagaatttca aggacacctc 1920
catgcagaag actatacctc tggtggccct cacactcaca tcttacctgg gcttgacaca 1980
accttttttg ggcctgtgtg catttctggc aacccgcata tttgggcgaa ggagtatccc 2040
agtgaatgag gcactcgcag cagctggtct agtgggagtg ctggcaggac tggcttttca 2100
ggagatggag aacttccttg gtccgattgc agttggagga ctcctgatga tgctggttag 2160
cgtggctggg agggtggatg ggctagagct caagaagctt ggtgaagttt catgggaaga 2220
ggaggcggag atcagcggga gttccgcccg ctatgatgtg gcactcagtg aacaagggga 2280
gttcaagctg ctttctgaag agaaagtgcc atgggaccag gttgtgatga cctcgctggc 2340
cttggttggg gctgccctcc atccatttgc tcttctgctg gtccttgctg ggtggctgtt 2400
tcatgtcagg ggagctagga gaagtgggga tgtcttgtgg gatattccca ctcctaagat 2460
catcgaggaa tgtgaacatc tggaggatgg gatttatggc atattccagt caaccttctt 2520
gggggcctcc cagcgaggag tgggagtggc acagggaggg gtgttccaca caatgtggca 2580
tgtcacaaga ggagctttcc ttgtcaggaa tggcaagaag ttgattccat cttgggcttc 2640
agtaaaggaa gaccttgtcg cctatggtgg ctcatggaag ttggaaggca gatgggatgg 2700
agaggaagag gtccagttga tcgcggctgt tccaggaaag aacgtggtca acgtccagac 2760
aaaaccgagc ttgttcaaag tgaggaatgg gggagaaatc ggggctgtcg ctcttgacta 2820
tccgagtggc acttcaggat ctcctattgt taacaggaac ggagaggtga ttgggctgta 2880
cggcaatggc atccttgtcg gtgacaactc cttcgtgtcc gccatatccc agactgaggt 2940
gaaggaagaa ggaaaggagg agctccaaga gatcccgaca atgctaaaga aaggaatgac 3000
aactgtcctt gattttcatc ctggagctgg gaagacaaga cgtttcctcc cacagatctt 3060
ggccgagtgc gcacggagac gcttgcgcac tcttgtgttg gcccccacca gggttgttct 3120
ttctgaaatg aaggaggctt ttcacggcct ggacgtgaaa ttccacacac aggctttttc 3180
cgctcacggc agcgggagag aagtcattga tgccatgtgc catgccaccc taacttacag 3240
gatgttggaa ccaactaggg ttgttaactg ggaagtgatc attatggatg aagcccattt 3300
tttggatcca gctagcatag ccgctagagg ttgggcagcg cacagagcta gggcaaatga 3360
aagtgcaaca atcttgatga cagccacacc gcctgggact agtgatgaat ttccacattc 3420
aaatggtgaa atagaagatg ttcaaacgga catacccagt gagccctgga acacagggca 3480
tgactggatc ctggctgaca aaaggcccac ggcatggttc cttccatcca tcagagctgc 3540
aaatgtcatg gctgcctctt tgcgtaaggc tggaaagagt gtggtggtcc tgaacaggaa 3600
aacctttgag agagaatacc ccacgataaa gcagaagaaa cctgacttta tattggccac 3660
tgacatagct gaaatgggag ccaacctttg cgtggagcga gtgctggatt gcaggacggc 3720
ttttaagcct gtgcttgtgg atgaagggag gaaggtggca ataaaagggc cacttcgtat 3780
ctccgcatcc tctgctgctc aaaggagggg gcgcattggg agaaatccca acagagatgg 3840
agactcatac tactattctg agcctacaag tgaaaataat gcccaccacg tctgctggtt 3900
ggaggcctca atgctcttgg acaacatgga ggtgaggggt ggaatggtcg ccccactcta 3960
tggcgttgaa ggaactaaaa caccagtttc ccctggtgaa atgagactga gggatgacca 4020
gaggaaagtc ttcagagaac tagtgaggaa ttgtgacctg cccgtttggc tttcgtggca 4080
agtggccaag gctggtttga agacgaatga tcgtaagtgg tgttttgaag gccctgagga 4140
acatgagatc ttgaatgaca gcggtgaaac agtgaagtgc agggctcctg gaggagcaaa 4200
gaagcctctg cgcccaaggt ggtgtgatga aagggtgtca tctgaccaga gtgcgctgtc 4260
tgaatttatt aagtttgctg aaggtaggag gggagctgct gaagtgctag ttgtgctgag 4320
tgaactccct gatttcctgg ctaaaaaagg tggagaggca atggatacca tcagtgtgtt 4380
cctccactct gaggaaggct ctagggctta ccgcaatgca ctatcaatga tgcctgaggc 4440
aatgacaata gtcatgctgt ttatactggc tggactactg acatcgggaa tggtcatctt 4500
tttcatgtct cccaaaggca tcagtagaat gtctatggcg atgggcacaa tggccggctg 4560
tggatatctc atgttccttg gaggcgtcaa acccactcac atctcctatg tcatgctcat 4620
attctttgtc ctgatggtgg ttgtgatccc cgagccaggg caacaaaggt ccatccaaga 4680
caaccaagtg gcatacctca ttattggcat cctgacgctg gtttcagcgg tggcagccaa 4740
cgagctaggc atgctggaga aaaccaaaga ggacctcttt gggaagaaga acttaattcc 4800
atctagtgct tcaccctgga gttggccgga tcttgacctg aagccaggag ctgcctggac 4860
agtgtacgtt ggcattgtta caatgctctc tccaatgttg caccactgga tcaaagtcga 4920
atatggcaac ctgtctctgt ctggaatagc ccagtcagcc tcagtccttt ctttcatgga 4980
caaggggata ccattcatga agatgaatat ctcggtcata atgctgctgg tcagtggctg 5040
gaattcaata acagtgatgc ctctgctctg tggcataggg tgcgccatgc tccactggtc 5100
tctcatttta cctggaatca aagcgcagca gtcaaagctt gcacagagaa gggtgttcca 5160
tggcgttgcc aagaaccctg tggttgatgg gaatccaaca gttgacattg aggaagctcc 5220
tgaaatgcct gccctttatg agaagaaact ggctctatat ctccttcttg ctctcagcct 5280
agcttctgtt gccatgtgca gaacgccctt ttcattggct gaaggcattg tcctagcatc 5340
agctgcctta gggccgctca tagagggaaa caccagcctt ctttggaatg gacccatggc 5400
tgtctccatg acaggagtca tgagggggaa tcactatgct tttgtgggag tcatgtacaa 5460
tctatggaag atgaaaactg gacgccgggg gagcgcgaat ggaaaaactt tgggtgaagt 5520
ctggaagagg gaactgaatc tgttggacaa gcgacagttt gagttgtata aaaggaccga 5580
cattgtggag gtggatcgtg atacggcacg caggcatttg gccgaaggga aggtggacac 5640
cggggtggcg gtctccaggg ggaccgcaaa gttaaggtgg ttccatgagc gtggctatgt 5700
caagctggaa ggtagggtga ttgacctggg gtgtggccgc ggaggctggt gttactacgc 5760
tgctgcgcaa aaggaagtga gtggggtcaa aggatttact cttggaagag acggccatga 5820
gaaacccatg aatgtgcaaa gtctgggatg gaacatcatc accttcaagg acaaaactga 5880
tatccaccgc ctagaaccag tgaaatgtga cacccttttg tgtgacattg gagagtcatc 5940
atcgtcatcg gtcacagagg gggaaaggac cgtgagagtt cttgatactg tagaaaaatg 6000
gctggcttgt ggggttgaca acttctgtgt gaaggtgtta gctccataca tgccagatgt 6060
tcttgagaaa ctggaattgc tccaaaggag gtttggcgga acagtgatca ggaaccctct 6120
ctccaggaat tccactcatg aaatgtacta cgtgtctgga gcccgcagca atgtcacatt 6180
tactgtgaac caaacatccc gcctcctgat gaggagaatg aggcgtccaa ctggaaaagt 6240
gaccctggag gctgacgtca tcctcccaat tgggacacgc agtgttgaga cagacaaggg 6300
acccctggac aaagaggcca tagaagaaag ggttgagagg ataaaatctg agtacatgac 6360
ctcttggttt tatgacaatg acaaccccta caggacctgg cactactgtg gctcctatgt 6420
cacaaaaacc tcaggaagtg cggcgagcat ggtaaatggt gttattaaaa ttctgacata 6480
tccatgggac aggatagagg aggtcacaag aatggcaatg actgacacaa ccccttttgg 6540
acagcaaaga gtgtttaaag aaaaagttga caccagagca aaggatccac cagcgggaac 6600
taggaagatc atgaaagttg tcaacaggtg gctgttccgc cacctggcca gagaaaagaa 6660
ccccagactg tgcacaaagg aagaatttat tgcaaaagtc cgaagtcatg cagccattgg 6720
agcttacctg gaagaacaag aacagtggaa gactgccaat gaggctgtcc aagacccaaa 6780
gttctgggaa ctggtggatg aagaaaggaa gctgcaccaa caaggcaggt gtcggacttg 6840
tgtgtacaac atgatgggga aaagagagaa gaagctgtca gagtttggga aagcaaaggg 6900
aagccgtgcc atatggtata tgtggctggg agcgcggtat cttgagtttg aggccctggg 6960
attcctgaat gaggaccatt gggcttccag ggaaaactca ggaggaggag tggaaggcat 7020
tggcttacaa tacctaggat atgtgatcag agacctggct gcaatggatg gtggtggatt 7080
ctacgcggat gacaccgctg gatgggacac gcgcatcaca gaggcagacc ttgatgatga 7140
acaggagatc ttgaactaca tgagcccaca tcacaaaaaa ctggcacaag cagtgatgga 7200
aatgacatac aagaacaaag tggtgaaagt gttgagacca gccccaggag ggaaagccta 7260
catggatgtc ataagtcgac gagaccagag aggatccggg caggtagtga cttatgctct 7320
gaacaccatc accaacttga aagtccaatt gatcagaatg gcagaagcag agatggtgat 7380
acatcaccaa catgttcaag attgtgatga atcagttctg accaggctgg aggcatggct 7440
cactgagcac ggatgtgaca gactgaagag gatggcggtg agtggagacg actgtgtggt 7500
ccggcccatc gatgacaggt tcggcctggc cctgtcccat ctcaacgcca tgtccaaggt 7560
tagaaaggac atatctgaat ggcagccatc aaaagggtgg aatgattggg agaatgtgcc 7620
cttctgttcc caccacttcc atgaactaca gctgaaggat ggcaggagga ttgtggtgcc 7680
ttgccgagaa caggacgagc tcattgggag aggaagggtg tctccaggaa acggctggat 7740
gatcaaggaa acagcttgcc tcagcaaagc ctatgccaac atgtggtcac tgatgtattt 7800
tcacaaaagg gacatgaggc tactgtcatt ggctgtttcc tcagctgttc ccacctcatg 7860
ggttccacaa ggacgcacaa catggtcgat tcatgggaaa ggggagtgga tgaccacgga 7920
agacatgctt gaggtgtgga acagagtatg gataaccaac aacccacaca tgcaggacaa 7980
gacaatggtg aaaaaatgga gagatgtccc ttatctaacc aagagacaag acaagctgtg 8040
cggatcactg attggaatga ccaatagggc cacctgggcc tcccacatcc atttagtcat 8100
ccatcgtatc cgaacgctga ttggacagga gaaatacact gactacctaa cagtcatgga 8160
caggtattct gtggatgctg acctgcaact gggtgagctt atctgaaaca ccatctaaca 8220
ggaataaccg ggatacaaac cacgggtgga gaaccggact ccccacaacc tgaaaccggg 8280
atataaacca cggctggaga accggactcc gcacttaaaa tgaaacagaa accgggataa 8340
aaactacgga tggagaaccg gactccacac attgagacag aagaagttgt cagcccagaa 8400
ccccacacga gttttgccac tgctaagctg tgaggcagtg caggctggga cagccgacct 8460
ccaggttgcg aaaaacctgg tttctgggac ctcccacccc agagtaaaaa gaacggagcc 8520
tccgctacca ccctcccacg tggtggtaga aagacggggt ctagaggtta gaggagaccc 8580
tccagggaac aaatagtggg accatattga cgccagggaa agaccggagt ggttctctgc 8640
ttttcctcca gaggtctgtg agcacagttt gctcaagaat aagcagacct ttggatgaca 8700
aacacaaaac cactcgag 8718
<210> 102
<211> 8358
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 102
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat ggccactgac acatacgatt ggaacatcag ttgaagagag 660
tgaaatgttc atgccgagat caatcggagg cccagttagc tctcacaatc atatccctgg 720
atacaaggtt cagacgaacg gaccttggat gcaggtacca ctagaagtga agagagaagc 780
ttgcccaggg actagcgtga tcattgatgg caactgtgat ggacggggaa aatcaaccag 840
atccaccacg gatagcggga aagttattcc tgaatggtgt tgccgctcct gcacaatgcc 900
gcctgtgagc ttccatggta gtgatgggtg ttggtatccc atggaaatta ggccaaggaa 960
aacgcatgaa agccatctgg tgcgctcctg ggttacagct ggagaaatac atgctgtccc 1020
ttttggtttg gtgagcatga tgatagcaat ggaagtggtc ctaaggaaaa gacagggacc 1080
aaagcaaatg ttggttggag gagtagtgct cttgggagca atgctggtcg ggcaagtaac 1140
tctccttgat ttgctgaaac tcacagtggc tgtgggattg catttccatg agatgaacaa 1200
tggaggagac gccatgtata tggcgttgat tgctgccttt tcaatcagac cagggctgct 1260
catcggcttt gggctcagga ccctatggag ccctcgggaa cgccttgtgc tgaccctagg 1320
agcagccatg gtggagattg ccttgggtgg cgtgatgggc ggcctgtgga agtatctaaa 1380
tgcagtttct ctctgcatcc tgacaataaa tgctgttgct tctaggaaag catcaaatac 1440
catcttgccc ctcatggctc tgttgacacc tgtcactatg gctgaggtga gacttgccgc 1500
aatgttcttt tgtgccatgg ttatcatagg ggtccttcac cagaatttca aggacacctc 1560
catgcagaag actatacctc tggtggccct cacactcaca tcttacctgg gcttgacaca 1620
accttttttg ggcctgtgtg catttctggc aacccgcata tttgggcgaa ggagtatccc 1680
agtgaatgag gcactcgcag cagctggtct agtgggagtg ctggcaggac tggcttttca 1740
ggagatggag aacttccttg gtccgattgc agttggagga ctcctgatga tgctggttag 1800
cgtggctggg agggtggatg ggctagagct caagaagctt ggtgaagttt catgggaaga 1860
ggaggcggag atcagcggga gttccgcccg ctatgatgtg gcactcagtg aacaagggga 1920
gttcaagctg ctttctgaag agaaagtgcc atgggaccag gttgtgatga cctcgctggc 1980
cttggttggg gctgccctcc atccatttgc tcttctgctg gtccttgctg ggtggctgtt 2040
tcatgtcagg ggagctagga gaagtgggga tgtcttgtgg gatattccca ctcctaagat 2100
catcgaggaa tgtgaacatc tggaggatgg gatttatggc atattccagt caaccttctt 2160
gggggcctcc cagcgaggag tgggagtggc acagggaggg gtgttccaca caatgtggca 2220
tgtcacaaga ggagctttcc ttgtcaggaa tggcaagaag ttgattccat cttgggcttc 2280
agtaaaggaa gaccttgtcg cctatggtgg ctcatggaag ttggaaggca gatgggatgg 2340
agaggaagag gtccagttga tcgcggctgt tccaggaaag aacgtggtca acgtccagac 2400
aaaaccgagc ttgttcaaag tgaggaatgg gggagaaatc ggggctgtcg ctcttgacta 2460
tccgagtggc acttcaggat ctcctattgt taacaggaac ggagaggtga ttgggctgta 2520
cggcaatggc atccttgtcg gtgacaactc cttcgtgtcc gccatatccc agactgaggt 2580
gaaggaagaa ggaaaggagg agctccaaga gatcccgaca atgctaaaga aaggaatgac 2640
aactgtcctt gattttcatc ctggagctgg gaagacaaga cgtttcctcc cacagatctt 2700
ggccgagtgc gcacggagac gcttgcgcac tcttgtgttg gcccccacca gggttgttct 2760
ttctgaaatg aaggaggctt ttcacggcct ggacgtgaaa ttccacacac aggctttttc 2820
cgctcacggc agcgggagag aagtcattga tgccatgtgc catgccaccc taacttacag 2880
gatgttggaa ccaactaggg ttgttaactg ggaagtgatc attatggatg aagcccattt 2940
tttggatcca gctagcatag ccgctagagg ttgggcagcg cacagagcta gggcaaatga 3000
aagtgcaaca atcttgatga cagccacacc gcctgggact agtgatgaat ttccacattc 3060
aaatggtgaa atagaagatg ttcaaacgga catacccagt gagccctgga acacagggca 3120
tgactggatc ctggctgaca aaaggcccac ggcatggttc cttccatcca tcagagctgc 3180
aaatgtcatg gctgcctctt tgcgtaaggc tggaaagagt gtggtggtcc tgaacaggaa 3240
aacctttgag agagaatacc ccacgataaa gcagaagaaa cctgacttta tattggccac 3300
tgacatagct gaaatgggag ccaacctttg cgtggagcga gtgctggatt gcaggacggc 3360
ttttaagcct gtgcttgtgg atgaagggag gaaggtggca ataaaagggc cacttcgtat 3420
ctccgcatcc tctgctgctc aaaggagggg gcgcattggg agaaatccca acagagatgg 3480
agactcatac tactattctg agcctacaag tgaaaataat gcccaccacg tctgctggtt 3540
ggaggcctca atgctcttgg acaacatgga ggtgaggggt ggaatggtcg ccccactcta 3600
tggcgttgaa ggaactaaaa caccagtttc ccctggtgaa atgagactga gggatgacca 3660
gaggaaagtc ttcagagaac tagtgaggaa ttgtgacctg cccgtttggc tttcgtggca 3720
agtggccaag gctggtttga agacgaatga tcgtaagtgg tgttttgaag gccctgagga 3780
acatgagatc ttgaatgaca gcggtgaaac agtgaagtgc agggctcctg gaggagcaaa 3840
gaagcctctg cgcccaaggt ggtgtgatga aagggtgtca tctgaccaga gtgcgctgtc 3900
tgaatttatt aagtttgctg aaggtaggag gggagctgct gaagtgctag ttgtgctgag 3960
tgaactccct gatttcctgg ctaaaaaagg tggagaggca atggatacca tcagtgtgtt 4020
cctccactct gaggaaggct ctagggctta ccgcaatgca ctatcaatga tgcctgaggc 4080
aatgacaata gtcatgctgt ttatactggc tggactactg acatcgggaa tggtcatctt 4140
tttcatgtct cccaaaggca tcagtagaat gtctatggcg atgggcacaa tggccggctg 4200
tggatatctc atgttccttg gaggcgtcaa acccactcac atctcctatg tcatgctcat 4260
attctttgtc ctgatggtgg ttgtgatccc cgagccaggg caacaaaggt ccatccaaga 4320
caaccaagtg gcatacctca ttattggcat cctgacgctg gtttcagcgg tggcagccaa 4380
cgagctaggc atgctggaga aaaccaaaga ggacctcttt gggaagaaga acttaattcc 4440
atctagtgct tcaccctgga gttggccgga tcttgacctg aagccaggag ctgcctggac 4500
agtgtacgtt ggcattgtta caatgctctc tccaatgttg caccactgga tcaaagtcga 4560
atatggcaac ctgtctctgt ctggaatagc ccagtcagcc tcagtccttt ctttcatgga 4620
caaggggata ccattcatga agatgaatat ctcggtcata atgctgctgg tcagtggctg 4680
gaattcaata acagtgatgc ctctgctctg tggcataggg tgcgccatgc tccactggtc 4740
tctcatttta cctggaatca aagcgcagca gtcaaagctt gcacagagaa gggtgttcca 4800
tggcgttgcc aagaaccctg tggttgatgg gaatccaaca gttgacattg aggaagctcc 4860
tgaaatgcct gccctttatg agaagaaact ggctctatat ctccttcttg ctctcagcct 4920
agcttctgtt gccatgtgca gaacgccctt ttcattggct gaaggcattg tcctagcatc 4980
agctgcctta gggccgctca tagagggaaa caccagcctt ctttggaatg gacccatggc 5040
tgtctccatg acaggagtca tgagggggaa tcactatgct tttgtgggag tcatgtacaa 5100
tctatggaag atgaaaactg gacgccgggg gagcgcgaat ggaaaaactt tgggtgaagt 5160
ctggaagagg gaactgaatc tgttggacaa gcgacagttt gagttgtata aaaggaccga 5220
cattgtggag gtggatcgtg atacggcacg caggcatttg gccgaaggga aggtggacac 5280
cggggtggcg gtctccaggg ggaccgcaaa gttaaggtgg ttccatgagc gtggctatgt 5340
caagctggaa ggtagggtga ttgacctggg gtgtggccgc ggaggctggt gttactacgc 5400
tgctgcgcaa aaggaagtga gtggggtcaa aggatttact cttggaagag acggccatga 5460
gaaacccatg aatgtgcaaa gtctgggatg gaacatcatc accttcaagg acaaaactga 5520
tatccaccgc ctagaaccag tgaaatgtga cacccttttg tgtgacattg gagagtcatc 5580
atcgtcatcg gtcacagagg gggaaaggac cgtgagagtt cttgatactg tagaaaaatg 5640
gctggcttgt ggggttgaca acttctgtgt gaaggtgtta gctccataca tgccagatgt 5700
tcttgagaaa ctggaattgc tccaaaggag gtttggcgga acagtgatca ggaaccctct 5760
ctccaggaat tccactcatg aaatgtacta cgtgtctgga gcccgcagca atgtcacatt 5820
tactgtgaac caaacatccc gcctcctgat gaggagaatg aggcgtccaa ctggaaaagt 5880
gaccctggag gctgacgtca tcctcccaat tgggacacgc agtgttgaga cagacaaggg 5940
acccctggac aaagaggcca tagaagaaag ggttgagagg ataaaatctg agtacatgac 6000
ctcttggttt tatgacaatg acaaccccta caggacctgg cactactgtg gctcctatgt 6060
cacaaaaacc tcaggaagtg cggcgagcat ggtaaatggt gttattaaaa ttctgacata 6120
tccatgggac aggatagagg aggtcacaag aatggcaatg actgacacaa ccccttttgg 6180
acagcaaaga gtgtttaaag aaaaagttga caccagagca aaggatccac cagcgggaac 6240
taggaagatc atgaaagttg tcaacaggtg gctgttccgc cacctggcca gagaaaagaa 6300
ccccagactg tgcacaaagg aagaatttat tgcaaaagtc cgaagtcatg cagccattgg 6360
agcttacctg gaagaacaag aacagtggaa gactgccaat gaggctgtcc aagacccaaa 6420
gttctgggaa ctggtggatg aagaaaggaa gctgcaccaa caaggcaggt gtcggacttg 6480
tgtgtacaac atgatgggga aaagagagaa gaagctgtca gagtttggga aagcaaaggg 6540
aagccgtgcc atatggtata tgtggctggg agcgcggtat cttgagtttg aggccctggg 6600
attcctgaat gaggaccatt gggcttccag ggaaaactca ggaggaggag tggaaggcat 6660
tggcttacaa tacctaggat atgtgatcag agacctggct gcaatggatg gtggtggatt 6720
ctacgcggat gacaccgctg gatgggacac gcgcatcaca gaggcagacc ttgatgatga 6780
acaggagatc ttgaactaca tgagcccaca tcacaaaaaa ctggcacaag cagtgatgga 6840
aatgacatac aagaacaaag tggtgaaagt gttgagacca gccccaggag ggaaagccta 6900
catggatgtc ataagtcgac gagaccagag aggatccggg caggtagtga cttatgctct 6960
gaacaccatc accaacttga aagtccaatt gatcagaatg gcagaagcag agatggtgat 7020
acatcaccaa catgttcaag attgtgatga atcagttctg accaggctgg aggcatggct 7080
cactgagcac ggatgtgaca gactgaagag gatggcggtg agtggagacg actgtgtggt 7140
ccggcccatc gatgacaggt tcggcctggc cctgtcccat ctcaacgcca tgtccaaggt 7200
tagaaaggac atatctgaat ggcagccatc aaaagggtgg aatgattggg agaatgtgcc 7260
cttctgttcc caccacttcc atgaactaca gctgaaggat ggcaggagga ttgtggtgcc 7320
ttgccgagaa caggacgagc tcattgggag aggaagggtg tctccaggaa acggctggat 7380
gatcaaggaa acagcttgcc tcagcaaagc ctatgccaac atgtggtcac tgatgtattt 7440
tcacaaaagg gacatgaggc tactgtcatt ggctgtttcc tcagctgttc ccacctcatg 7500
ggttccacaa ggacgcacaa catggtcgat tcatgggaaa ggggagtgga tgaccacgga 7560
agacatgctt gaggtgtgga acagagtatg gataaccaac aacccacaca tgcaggacaa 7620
gacaatggtg aaaaaatgga gagatgtccc ttatctaacc aagagacaag acaagctgtg 7680
cggatcactg attggaatga ccaatagggc cacctgggcc tcccacatcc atttagtcat 7740
ccatcgtatc cgaacgctga ttggacagga gaaatacact gactacctaa cagtcatgga 7800
caggtattct gtggatgctg acctgcaact gggtgagctt atctgaaaca ccatctaaca 7860
ggaataaccg ggatacaaac cacgggtgga gaaccggact ccccacaacc tgaaaccggg 7920
atataaacca cggctggaga accggactcc gcacttaaaa tgaaacagaa accgggataa 7980
aaactacgga tggagaaccg gactccacac attgagacag aagaagttgt cagcccagaa 8040
ccccacacga gttttgccac tgctaagctg tgaggcagtg caggctggga cagccgacct 8100
ccaggttgcg aaaaacctgg tttctgggac ctcccacccc agagtaaaaa gaacggagcc 8160
tccgctacca ccctcccacg tggtggtaga aagacggggt ctagaggtta gaggagaccc 8220
tccagggaac aaatagtggg accatattga cgccagggaa agaccggagt ggttctctgc 8280
ttttcctcca gaggtctgtg agcacagttt gctcaagaat aagcagacct ttggatgaca 8340
aacacaaaac cactcgag 8358
<210> 103
<211> 9132
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 103
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggag ttggggcgga 720
tcaaggatgc gccatcaact ttggcaagag agagctcaag tgcggagatg gtatcttcat 780
atttagagac tctgatgact ggctgaacaa gtactcatac tatccagaag atcctgtgaa 840
gcttgcatca atagtgaaag cctcttttga agaagggaag tgtggcctaa attcagttga 900
ctcccttgag catgagatgt ggagaagcag ggcagatgag atcaatgcca tttttgagga 960
aaacgaggtg gacatttctg ttgtcgtgca ggatccaaag aatgtttacc agagaggaac 1020
tcatccattt tccagaattc gggatggtct gcagtatggt tggaagactt ggggtaagaa 1080
ccttgtgttc tccccaggga ggaagaatgg aagcttcatc atagatggaa agtccaggaa 1140
agaatgcccg ttttcaaacc gggtctggaa ttctttccag atagaggagt ttgggacggg 1200
agtgttcacc acacgcgtgt acatggacgc agtctttgaa tacaccatag actgcgatgg 1260
atctatcttg ggtgcagcgg tgaacggaaa aaagagtgcc catggctctc caacattttg 1320
gatgggaagt catgaagtaa atgggacatg gatgatccac accttggagg cattagatta 1380
caaggagtgt gagtggccac tgacacatac gattggaaca tcagttgaag agagtgaaat 1440
gttcatgccg agatcaatcg gaggcccagt tagctctcac aatcatatcc ctggatacaa 1500
ggttcagacg aacggacctt ggatgcaggt accactagaa gtgaagagag aagcttgccc 1560
agggactagc gtgatcattg atggcaactg tgatggacgg ggaaaatcaa ccagatccac 1620
cacggatagc gggaaagtta ttcctgaatg gtgttgccgc tcctgcacaa tgccgcctgt 1680
gagcttccat ggtagtgatg ggtgttggta tcccatggaa attaggccaa ggaaaacgca 1740
tgaaagccat ctggtgcgct cctgggttac agctggagaa atacatgctg tcccttttgg 1800
tttggtgagc atgatgatag caatggaagt ggtcctaagg aaaagacagg gaccaaagca 1860
aatgttggtt ggaggagtag tgctcttggg agcaatgctg gtcgggcaag taactctcct 1920
tgatttgctg aaactcacag tggctgtggg attgcatttc catgagatga acaatggagg 1980
agacgccatg tatatggcgt tgattgctgc cttttcaatc agaccagggc tgctcatcgg 2040
ctttgggctc aggaccctat ggagccctcg ggaacgcctt gtgctgaccc taggagcagc 2100
catggtggag attgccttgg gtggcgtgat gggcggcctg tggaagtatc taaatgcagt 2160
ttctctctgc atcctgacaa taaatgctgt tgcttctagg aaagcatcaa ataccatctt 2220
gcccctcatg gctctgttga cacctgtcac tatggctgag gtgagacttg ccgcaatgtt 2280
cttttgtgcc atggttatca taggggtcct tcaccagaat ttcaaggaca cctccatgca 2340
gaagactata cctctggtgg ccctcacact cacatcttac ctgggcttga cacaaccttt 2400
tttgggcctg tgtgcatttc tggcaacccg catatttggg cgaaggagta tcccagtgaa 2460
tgaggcactc gcagcagctg gtctagtggg agtgctggca ggactggctt ttcaggagat 2520
ggagaacttc cttggtccga ttgcagttgg aggactcctg atgatgctgg ttagcgtggc 2580
tgggagggtg gatgggctag agctcaagaa gcttggtgaa gtttcatggg aagaggaggc 2640
ggagatcagc gggagttccg cccgctatga tgtggcactc agtgaacaag gggagttcaa 2700
gctgctttct gaagagaaag tgccatggga ccaggttgtg atgacctcgc tggccttggt 2760
tggggctgcc ctccatccat ttgctcttct gctggtcctt gctgggtggc tgtttcatgt 2820
caggggagct aggagaagtg gggatgtctt gtgggatatt cccactccta agatcatcga 2880
ggaatgtgaa catctggagg atgggattta tggcatattc cagtcaacct tcttgggggc 2940
ctcccagcga ggagtgggag tggcacaggg aggggtgttc cacacaatgt ggcatgtcac 3000
aagaggagct ttccttgtca ggaatggcaa gaagttgatt ccatcttggg cttcagtaaa 3060
ggaagacctt gtcgcctatg gtggctcatg gaagttggaa ggcagatggg atggagagga 3120
agaggtccag ttgatcgcgg ctgttccagg aaagaacgtg gtcaacgtcc agacaaaacc 3180
gagcttgttc aaagtgagga atgggggaga aatcggggct gtcgctcttg actatccgag 3240
tggcacttca ggatctccta ttgttaacag gaacggagag gtgattgggc tgtacggcaa 3300
tggcatcctt gtcggtgaca actccttcgt gtccgccata tcccagactg aggtgaagga 3360
agaaggaaag gaggagctcc aagagatccc gacaatgcta aagaaaggaa tgacaactgt 3420
ccttgatttt catcctggag ctgggaagac aagacgtttc ctcccacaga tcttggccga 3480
gtgcgcacgg agacgcttgc gcactcttgt gttggccccc accagggttg ttctttctga 3540
aatgaaggag gcttttcacg gcctggacgt gaaattccac acacaggctt tttccgctca 3600
cggcagcggg agagaagtca ttgatgccat gtgccatgcc accctaactt acaggatgtt 3660
ggaaccaact agggttgtta actgggaagt gatcattatg gatgaagccc attttttgga 3720
tccagctagc atagccgcta gaggttgggc agcgcacaga gctagggcaa atgaaagtgc 3780
aacaatcttg atgacagcca caccgcctgg gactagtgat gaatttccac attcaaatgg 3840
tgaaatagaa gatgttcaaa cggacatacc cagtgagccc tggaacacag ggcatgactg 3900
gatcctggct gacaaaaggc ccacggcatg gttccttcca tccatcagag ctgcaaatgt 3960
catggctgcc tctttgcgta aggctggaaa gagtgtggtg gtcctgaaca ggaaaacctt 4020
tgagagagaa taccccacga taaagcagaa gaaacctgac tttatattgg ccactgacat 4080
agctgaaatg ggagccaacc tttgcgtgga gcgagtgctg gattgcagga cggcttttaa 4140
gcctgtgctt gtggatgaag ggaggaaggt ggcaataaaa gggccacttc gtatctccgc 4200
atcctctgct gctcaaagga gggggcgcat tgggagaaat cccaacagag atggagactc 4260
atactactat tctgagccta caagtgaaaa taatgcccac cacgtctgct ggttggaggc 4320
ctcaatgctc ttggacaaca tggaggtgag gggtggaatg gtcgccccac tctatggcgt 4380
tgaaggaact aaaacaccag tttcccctgg tgaaatgaga ctgagggatg accagaggaa 4440
agtcttcaga gaactagtga ggaattgtga cctgcccgtt tggctttcgt ggcaagtggc 4500
caaggctggt ttgaagacga atgatcgtaa gtggtgtttt gaaggccctg aggaacatga 4560
gatcttgaat gacagcggtg aaacagtgaa gtgcagggct cctggaggag caaagaagcc 4620
tctgcgccca aggtggtgtg atgaaagggt gtcatctgac cagagtgcgc tgtctgaatt 4680
tattaagttt gctgaaggta ggaggggagc tgctgaagtg ctagttgtgc tgagtgaact 4740
ccctgatttc ctggctaaaa aaggtggaga ggcaatggat accatcagtg tgttcctcca 4800
ctctgaggaa ggctctaggg cttaccgcaa tgcactatca atgatgcctg aggcaatgac 4860
aatagtcatg ctgtttatac tggctggact actgacatcg ggaatggtca tctttttcat 4920
gtctcccaaa ggcatcagta gaatgtctat ggcgatgggc acaatggccg gctgtggata 4980
tctcatgttc cttggaggcg tcaaacccac tcacatctcc tatgtcatgc tcatattctt 5040
tgtcctgatg gtggttgtga tccccgagcc agggcaacaa aggtccatcc aagacaacca 5100
agtggcatac ctcattattg gcatcctgac gctggtttca gcggtggcag ccaacgagct 5160
aggcatgctg gagaaaacca aagaggacct ctttgggaag aagaacttaa ttccatctag 5220
tgcttcaccc tggagttggc cggatcttga cctgaagcca ggagctgcct ggacagtgta 5280
cgttggcatt gttacaatgc tctctccaat gttgcaccac tggatcaaag tcgaatatgg 5340
caacctgtct ctgtctggaa tagcccagtc agcctcagtc ctttctttca tggacaaggg 5400
gataccattc atgaagatga atatctcggt cataatgctg ctggtcagtg gctggaattc 5460
aataacagtg atgcctctgc tctgtggcat agggtgcgcc atgctccact ggtctctcat 5520
tttacctgga atcaaagcgc agcagtcaaa gcttgcacag agaagggtgt tccatggcgt 5580
tgccaagaac cctgtggttg atgggaatcc aacagttgac attgaggaag ctcctgaaat 5640
gcctgccctt tatgagaaga aactggctct atatctcctt cttgctctca gcctagcttc 5700
tgttgccatg tgcagaacgc ccttttcatt ggctgaaggc attgtcctag catcagctgc 5760
cttagggccg ctcatagagg gaaacaccag ccttctttgg aatggaccca tggctgtctc 5820
catgacagga gtcatgaggg ggaatcacta tgcttttgtg ggagtcatgt acaatctatg 5880
gaagatgaaa actggacgcc gggggagcgc gaatggaaaa actttgggtg aagtctggaa 5940
gagggaactg aatctgttgg acaagcgaca gtttgagttg tataaaagga ccgacattgt 6000
ggaggtggat cgtgatacgg cacgcaggca tttggccgaa gggaaggtgg acaccggggt 6060
ggcggtctcc agggggaccg caaagttaag gtggttccat gagcgtggct atgtcaagct 6120
ggaaggtagg gtgattgacc tggggtgtgg ccgcggaggc tggtgttact acgctgctgc 6180
gcaaaaggaa gtgagtgggg tcaaaggatt tactcttgga agagacggcc atgagaaacc 6240
catgaatgtg caaagtctgg gatggaacat catcaccttc aaggacaaaa ctgatatcca 6300
ccgcctagaa ccagtgaaat gtgacaccct tttgtgtgac attggagagt catcatcgtc 6360
atcggtcaca gagggggaaa ggaccgtgag agttcttgat actgtagaaa aatggctggc 6420
ttgtggggtt gacaacttct gtgtgaaggt gttagctcca tacatgccag atgttcttga 6480
gaaactggaa ttgctccaaa ggaggtttgg cggaacagtg atcaggaacc ctctctccag 6540
gaattccact catgaaatgt actacgtgtc tggagcccgc agcaatgtca catttactgt 6600
gaaccaaaca tcccgcctcc tgatgaggag aatgaggcgt ccaactggaa aagtgaccct 6660
ggaggctgac gtcatcctcc caattgggac acgcagtgtt gagacagaca agggacccct 6720
ggacaaagag gccatagaag aaagggttga gaggataaaa tctgagtaca tgacctcttg 6780
gttttatgac aatgacaacc cctacaggac ctggcactac tgtggctcct atgtcacaaa 6840
aacctcagga agtgcggcga gcatggtaaa tggtgttatt aaaattctga catatccatg 6900
ggacaggata gaggaggtca caagaatggc aatgactgac acaacccctt ttggacagca 6960
aagagtgttt aaagaaaaag ttgacaccag agcaaaggat ccaccagcgg gaactaggaa 7020
gatcatgaaa gttgtcaaca ggtggctgtt ccgccacctg gccagagaaa agaaccccag 7080
actgtgcaca aaggaagaat ttattgcaaa agtccgaagt catgcagcca ttggagctta 7140
cctggaagaa caagaacagt ggaagactgc caatgaggct gtccaagacc caaagttctg 7200
ggaactggtg gatgaagaaa ggaagctgca ccaacaaggc aggtgtcgga cttgtgtgta 7260
caacatgatg gggaaaagag agaagaagct gtcagagttt gggaaagcaa agggaagccg 7320
tgccatatgg tatatgtggc tgggagcgcg gtatcttgag tttgaggccc tgggattcct 7380
gaatgaggac cattgggctt ccagggaaaa ctcaggagga ggagtggaag gcattggctt 7440
acaataccta ggatatgtga tcagagacct ggctgcaatg gatggtggtg gattctacgc 7500
ggatgacacc gctggatggg acacgcgcat cacagaggca gaccttgatg atgaacagga 7560
gatcttgaac tacatgagcc cacatcacaa aaaactggca caagcagtga tggaaatgac 7620
atacaagaac aaagtggtga aagtgttgag accagcccca ggagggaaag cctacatgga 7680
tgtcataagt cgacgagacc agagaggatc cgggcaggta gtgacttatg ctctgaacac 7740
catcaccaac ttgaaagtcc aattgatcag aatggcagaa gcagagatgg tgatacatca 7800
ccaacatgtt caagattgtg atgaatcagt tctgaccagg ctggaggcat ggctcactga 7860
gcacggatgt gacagactga agaggatggc ggtgagtgga gacgactgtg tggtccggcc 7920
catcgatgac aggttcggcc tggccctgtc ccatctcaac gccatgtcca aggttagaaa 7980
ggacatatct gaatggcagc catcaaaagg gtggaatgat tgggagaatg tgcccttctg 8040
ttcccaccac ttccatgaac tacagctgaa ggatggcagg aggattgtgg tgccttgccg 8100
agaacaggac gagctcattg ggagaggaag ggtgtctcca ggaaacggct ggatgatcaa 8160
ggaaacagct tgcctcagca aagcctatgc caacatgtgg tcactgatgt attttcacaa 8220
aagggacatg aggctactgt cattggctgt ttcctcagct gttcccacct catgggttcc 8280
acaaggacgc acaacatggt cgattcatgg gaaaggggag tggatgacca cggaagacat 8340
gcttgaggtg tggaacagag tatggataac caacaaccca cacatgcagg acaagacaat 8400
ggtgaaaaaa tggagagatg tcccttatct aaccaagaga caagacaagc tgtgcggatc 8460
actgattgga atgaccaata gggccacctg ggcctcccac atccatttag tcatccatcg 8520
tatccgaacg ctgattggac aggagaaata cactgactac ctaacagtca tggacaggta 8580
ttctgtggat gctgacctgc aactgggtga gcttatctga aacaccatct aacaggaata 8640
accgggatac aaaccacggg tggagaaccg gactccccac aacctgaaac cgggatataa 8700
accacggctg gagaaccgga ctccgcactt aaaatgaaac agaaaccggg ataaaaacta 8760
cggatggaga accggactcc acacattgag acagaagaag ttgtcagccc agaaccccac 8820
acgagttttg ccactgctaa gctgtgaggc agtgcaggct gggacagccg acctccaggt 8880
tgcgaaaaac ctggtttctg ggacctccca ccccagagta aaaagaacgg agcctccgct 8940
accaccctcc cacgtggtgg tagaaagacg gggtctagag gttagaggag accctccagg 9000
gaacaaatag tgggaccata ttgacgccag ggaaagaccg gagtggttct ctgcttttcc 9060
tccagaggtc tgtgagcaca gtttgctcaa gaataagcag acctttggat gacaaacaca 9120
aaaccactcg ag 9132
<210> 104
<211> 10770
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 104
agtaaatcct gtgtgctaat tgaggtgcat tggtctgcaa atcgagttgc taggcaataa 60
acacatttgg attaatttta atcgttcgtt gagcgattag cagagaactg accagaacat 120
gtctggtcgt aaagctcagg gaaaaaccct gggcgtcaat atggtacgac gaggagttcg 180
ctccttgtca aacaaaataa aacaaaaaac aaaacaaatt ggaaacagac ctggaccttc 240
aagaggtgtt caaggattta tctttttctt tttgttcaac attttgactg gaaaaaagat 300
cacagcccac ctaaagaggt tgtggaaaat gctggaccca agacaaggct tggctgttct 360
aaggaaagtc aagagagtgg tggccagttt gatgagagga ttgtcctcaa ggaaacgccg 420
ttcccatgat gttctgactg tgcaattcct aattttggga atgctgttga tgacgggtgg 480
agtgaccttg gtgcggaaaa acagatggtt gctcctaaat gtgacatctg aggacctcgg 540
gaaaacattc tctgtgggca caggcaactg cacaacaaac attttggaag ccaagtactg 600
gtgcccagac tcaatggaat acaactgtcc caatctcagt ccaagagagg agccagatga 660
cattgattgc tggtgctatg gggtggaaaa cgttagagtc gcatatggta agtgtgactc 720
agcaggcagg tctaggaggt caagaagggc cattgacttg cctacgcatg aaaaccatgg 780
tttgaagacc cggcaagaaa aatggatgac tggaagaatg ggtgaaaggc aactccaaaa 840
gattgagaga tggttcgtga ggaacccctt ttttgcagtg acggctctga ccattgccta 900
ccttgtggga agcaacatga cgcaacgagt cgtgattgcc ctactggtct tggctgttgg 960
tccggcctac tcagctcact gcattggaat tactgacagg gatttcattg agggggtgca 1020
tggaggaact tgggtttcag ctaccctgga gcaagacaag tgtgtcactg ttatggcccc 1080
tgacaagcct tcattggaca tctcactaga gacagtagcc attgatagac ctgctgaggt 1140
gaggaaagtg tgttacaatg cagttctcac tcatgtgaag attaatgaca agtgccccag 1200
cactggagag gcccacctag ctgaagagaa cgaaggggac aatgcgtgca agcgcactta 1260
ttctgataga ggctggggca atggctgtgg cctatttggg aaagggagca ttgtggcatg 1320
cgccaaattc acttgtgcca aatccatgag tttgtttgag gttgatcaga ccaaaattca 1380
gtatgtcatc agagcacaat tgcatgtagg ggccaagcag gaaaattgga ataccgacat 1440
taagactctc aagtttgatg ccctgtcagg ctcccaggaa agctggatag tggacagaca 1500
gtgggcccag gacttgaccc tgccatggca gagtggaagt ggcggggtgt ggagagagat 1560
gcatcatctt gtcgaatttg aacctccgca tgccgccact atcagagtac tggccctggg 1620
aaaccaggaa ggctccttga aaacagctct tactggcgca atgagggtta caaaggacac 1680
aaatgacaac aacctttaca aactacatgg tggacatgtt tcttgcagag tgaaattgtc 1740
agctttgaca ctcaagggga catcctacaa aatatgcact gacaaaatgt tttttgtcaa 1800
gaacccaact gacactggcc atggcactgt tgtgatgcag gtgaaagtgt caaaaggagc 1860
cccctgcagg attccagtga tagtagctga tgatcttaca gcggcaatca ataaaggcat 1920
tttggttaca gttaacccca tcgcctcaac caatgatgat gaagtgctga ttgaggtgaa 1980
cccacctttt ggagacagct acattatcgt tgggagagga gattcacgtc tcacttacca 2040
gtggcacaaa gagggaagct caataggaaa gttgttcact cagaccatga aaggcgtgga 2100
acgcctggcc gtcatgggag acaccgcctg ggatttcagc tccgctggag ggttcttcac 2160
ttcggttggg aaaggaattc atacggtgtt tggctctgcc tttcaggggc tatttggcgg 2220
cttgaactgg ataacaaagg tcatcatggg ggcggtactt atatgggttg gcatcaacac 2280
aagaaacatg acaatgtcca tgagcatgat cttggtagga gtgatcatga tgtttttgtc 2340
tctaggagtt ggggcggatc aaggatgcgc catcaacttt ggcaagagag agctcaagtg 2400
cggagatggt atcttcatat ttagagactc tgatgactgg ctgaacaagt actcatacta 2460
tccagaagat cctgtgaagc ttgcatcaat agtgaaagcc tcttttgaag aagggaagtg 2520
tggcctaaat tcagttgact cccttgagca tgagatgtgg agaagcaggg cagatgagat 2580
caatgccatt tttgaggaaa acgaggtgga catttctgtt gtcgtgcagg atccaaagaa 2640
tgtttaccag agaggaactc atccattttc cagaattcgg gatggtctgc agtatggttg 2700
gaagacttgg ggtaagaacc ttgtgttctc cccagggagg aagaatggaa gcttcatcat 2760
agatggaaag tccaggaaag aatgcccgtt ttcaaaccgg gtctggaatt ctttccagat 2820
agaggagttt gggacgggag tgttcaccac acgcgtgtac atggacgcag tctttgaata 2880
caccatagac tgcgatggat ctatcttggg tgcagcggtg aacggaaaaa agagtgccca 2940
tggctctcca acattttgga tgggaagtca tgaagtaaat gggacatgga tgatccacac 3000
cttggaggca ttagattaca aggagtgtga gtggccactg acacatacga ttggaacatc 3060
agttgaagag agtgaaatgt tcatgccgag atcaatcgga ggcccagtta gctctcacaa 3120
tcatatccct ggatacaagg ttcagacgaa cggaccttgg atgcaggtac cactagaagt 3180
gaagagagaa gcttgcccag ggactagcgt gatcattgat ggcaactgtg atggacgggg 3240
aaaatcaacc agatccacca cggatagcgg gaaagttatt cctgaatggt gttgccgctc 3300
ctgcacaatg ccgcctgtga gcttccatgg tagtgatggg tgttggtatc ccatggaaat 3360
taggccaagg aaaacgcatg aaagccatct ggtgcgctcc tgggttacag ctggagaaat 3420
acatgctgtc ccttttggtt tggtgagcat gatgatagca atggaagtgg tcctaaggaa 3480
aagacaggga ccaaagcaaa tgttggttgg aggagtagtg ctcttgggag caatgctggt 3540
cgggcaagta actctccttg atttgctgaa actcacagtg gctgtgggat tgcatttcca 3600
tgagatgaac aatggaggag acgccatgta tatggcgttg attgctgcct tttcaatcag 3660
accagggctg ctcatcggct ttgggctcag gaccctatgg agccctcggg aacgccttgt 3720
gctgacccta ggagcagcca tggtggagat tgccttgggt ggcgtgatgg gcggcctgtg 3780
gaagtatcta aatgcagttt ctctctgcat cctgacaata aatgctgttg cttctaggaa 3840
agcatcaaat accatcttgc ccctcatggc tctgttgaca cctgtcacta tggctgaggt 3900
gagacttgcc gcaatgttct tttgtgccat ggttatcata ggggtccttc accagaattt 3960
caaggacacc tccatgcaga agactatacc tctggtggcc ctcacactca catcttacct 4020
gggcttgaca caaccttttt tgggcctgtg tgcatttctg gcaacccgca tatttgggcg 4080
aaggagtatc ccagtgaatg aggcactcgc agcagctggt ctagtgggag tgctggcagg 4140
actggctttt caggagatgg agaacttcct tggtccgatt gcagttggag gactcctgat 4200
gatgctggtt agcgtggctg ggagggtgga tgggctagag ctcaagaagc ttggtgaagt 4260
ttcatgggaa gaggaggcgg agatcagcgg gagttccgcc cgctatgatg tggcactcag 4320
tgaacaaggg gagttcaagc tgctttctga agagaaagtg ccatgggacc aggttgtgat 4380
gacctcgctg gccttggttg gggctgccct ccatccattt gctcttctgc tggtccttgc 4440
tgggtggctg tttcatgtca ggggagctag gagaagtggg gatgtcttgt gggatattcc 4500
cactcctaag atcatcgagg aatgtgaaca tctggaggat gggatttatg gcatattcca 4560
gtcaaccttc ttgggggcct cccagcgagg agtgggagtg gcacagggag gggtgttcca 4620
cacaatgtgg catgtcacaa gaggagcttt ccttgtcagg aatggcaaga agttgattcc 4680
atcttgggct tcagtaaagg aagaccttgt cgcctatggt ggctcatgga agttggaagg 4740
cagatgggat ggagaggaag aggtccagtt gatcgcggct gttccaggaa agaacgtggt 4800
caacgtccag acaaaaccga gcttgttcaa agtgaggaat gggggagaaa tcggggctgt 4860
cgctcttgac tatccgagtg gcacttcagg atctcctatt gttaacagga acggagaggt 4920
gattgggctg tacggcaatg gcatccttgt cggtgacaac tccttcgtgt ccgccatatc 4980
ccagactgag gtgaaggaag aaggaaagga ggagctccaa gagatcccga caatgctaaa 5040
gaaaggaatg acaactgtcc ttgattttca tcctggagct gggaagacaa gacgtttcct 5100
cccacagatc ttggccgagt gcgcacggag acgcttgcgc actcttgtgt tggcccccac 5160
cagggttgtt ctttctgaaa tgaaggaggc ttttcacggc ctggacgtga aattccacac 5220
acaggctttt tccgctcacg gcagcgggag agaagtcatt gatgccatgt gccatgccac 5280
cctaacttac aggatgttgg aaccaactag ggttgttaac tgggaagtga tcattatgga 5340
tgaagcccat tttttggatc cagctagcat agccgctaga ggttgggcag cgcacagagc 5400
tagggcaaat gaaagtgcaa caatcttgat gacagccaca ccgcctggga ctagtgatga 5460
atttccacat tcaaatggtg aaatagaaga tgttcaaacg gacataccca gtgagccctg 5520
gaacacaggg catgactgga tcctggctga caaaaggccc acggcatggt tccttccatc 5580
catcagagct gcaaatgtca tggctgcctc tttgcgtaag gctggaaaga gtgtggtggt 5640
cctgaacagg aaaacctttg agagagaata ccccacgata aagcagaaga aacctgactt 5700
tatattggcc actgacatag ctgaaatggg agccaacctt tgcgtggagc gagtgctgga 5760
ttgcaggacg gcttttaagc ctgtgcttgt ggatgaaggg aggaaggtgg caataaaagg 5820
gccacttcgt atctccgcat cctctgctgc tcaaaggagg gggcgcattg ggagaaatcc 5880
caacagagat ggagactcat actactattc tgagcctaca agtgaaaata atgcccacca 5940
cgtctgctgg ttggaggcct caatgctctt ggacaacatg gaggtgaggg gtggaatggt 6000
cgccccactc tatggcgttg aaggaactaa aacaccagtt tcccctggtg aaatgagact 6060
gagggatgac cagaggaaag tcttcagaga actagtgagg aattgtgacc tgcccgtttg 6120
gctttcgtgg caagtggcca aggctggttt gaagacgaat gatcgtaagt ggtgttttga 6180
aggccctgag gaacatgaga tcttgaatga cagcggtgaa acagtgaagt gcagggctcc 6240
tggaggagca aagaagcctc tgcgcccaag gtggtgtgat gaaagggtgt catctgacca 6300
gagtgcgctg tctgaattta ttaagtttgc tgaaggtagg aggggagctg ctgaagtgct 6360
agttgtgctg agtgaactcc ctgatttcct ggctaaaaaa ggtggagagg caatggatac 6420
catcagtgtg ttcctccact ctgaggaagg ctctagggct taccgcaatg cactatcaat 6480
gatgcctgag gcaatgacaa tagtcatgct gtttatactg gctggactac tgacatcggg 6540
aatggtcatc tttttcatgt ctcccaaagg catcagtaga atgtctatgg cgatgggcac 6600
aatggccggc tgtggatatc tcatgttcct tggaggcgtc aaacccactc acatctccta 6660
tgtcatgctc atattctttg tcctgatggt ggttgtgatc cccgagccag ggcaacaaag 6720
gtccatccaa gacaaccaag tggcatacct cattattggc atcctgacgc tggtttcagc 6780
ggtggcagcc aacgagctag gcatgctgga gaaaaccaaa gaggacctct ttgggaagaa 6840
gaacttaatt ccatctagtg cttcaccctg gagttggccg gatcttgacc tgaagccagg 6900
agctgcctgg acagtgtacg ttggcattgt tacaatgctc tctccaatgt tgcaccactg 6960
gatcaaagtc gaatatggca acctgtctct gtctggaata gcccagtcag cctcagtcct 7020
ttctttcatg gacaagggga taccattcat gaagatgaat atctcggtca taatgctgct 7080
ggtcagtggc tggaattcaa taacagtgat gcctctgctc tgtggcatag ggtgcgccat 7140
gctccactgg tctctcattt tacctggaat caaagcgcag cagtcaaagc ttgcacagag 7200
aagggtgttc catggcgttg ccaagaaccc tgtggttgat gggaatccaa cagttgacat 7260
tgaggaagct cctgaaatgc ctgcccttta tgagaagaaa ctggctctat atctccttct 7320
tgctctcagc ctagcttctg ttgccatgtg cagaacgccc ttttcattgg ctgaaggcat 7380
tgtcctagca tcagctgcct tagggccgct catagaggga aacaccagcc ttctttggaa 7440
tggacccatg gctgtctcca tgacaggagt catgaggggg aatcactatg cttttgtggg 7500
agtcatgtac aatctatgga agatgaaaac tggacgccgg gggagcgcga atggaaaaac 7560
tttgggtgaa gtctggaaga gggaactgaa tctgttggac aagcgacagt ttgagttgta 7620
taaaaggacc gacattgtgg aggtggatcg tgatacggca cgcaggcatt tggccgaagg 7680
gaaggtggac accggggtgg cggtctccag ggggaccgca aagttaaggt ggttccatga 7740
gcgtggctat gtcaagctgg aaggtagggt gattgacctg gggtgtggcc gcggaggctg 7800
gtgttactac gctgctgcgc aaaaggaagt gagtggggtc aaaggattta ctcttggaag 7860
agacggccat gagaaaccca tgaatgtgca aagtctggga tggaacatca tcaccttcaa 7920
ggacaaaact gatatccacc gcctagaacc agtgaaatgt gacacccttt tgtgtgacat 7980
tggagagtca tcatcgtcat cggtcacaga gggggaaagg accgtgagag ttcttgatac 8040
tgtagaaaaa tggctggctt gtggggttga caacttctgt gtgaaggtgt tagctccata 8100
catgccagat gttcttgaga aactggaatt gctccaaagg aggtttggcg gaacagtgat 8160
caggaaccct ctctccagga attccactca tgaaatgtac tacgtgtctg gagcccgcag 8220
caatgtcaca tttactgtga accaaacatc ccgcctcctg atgaggagaa tgaggcgtcc 8280
aactggaaaa gtgaccctgg aggctgacgt catcctccca attgggacac gcagtgttga 8340
gacagacaag ggacccctgg acaaagaggc catagaagaa agggttgaga ggataaaatc 8400
tgagtacatg acctcttggt tttatgacaa tgacaacccc tacaggacct ggcactactg 8460
tggctcctat gtcacaaaaa cctcaggaag tgcggcgagc atggtaaatg gtgttattaa 8520
aattctgaca tatccatggg acaggataga ggaggtcaca agaatggcaa tgactgacac 8580
aacccctttt ggacagcaaa gagtgtttaa agaaaaagtt gacaccagag caaaggatcc 8640
accagcggga actaggaaga tcatgaaagt tgtcaacagg tggctgttcc gccacctggc 8700
cagagaaaag aaccccagac tgtgcacaaa ggaagaattt attgcaaaag tccgaagtca 8760
tgcagccatt ggagcttacc tggaagaaca agaacagtgg aagactgcca atgaggctgt 8820
ccaagaccca aagttctggg aactggtgga tgaagaaagg aagctgcacc aacaaggcag 8880
gtgtcggact tgtgtgtaca acatgatggg gaaaagagag aagaagctgt cagagtttgg 8940
gaaagcaaag ggaagccgtg ccatatggta tatgtggctg ggagcgcggt atcttgagtt 9000
tgaggccctg ggattcctga atgaggacca ttgggcttcc agggaaaact caggaggagg 9060
agtggaaggc attggcttac aatacctagg atatgtgatc agagacctgg ctgcaatgga 9120
tggtggtgga ttctacgcgg atgacaccgc tggatgggac acgcgcatca cagaggcaga 9180
ccttgatgat gaacaggaga tcttgaacta catgagccca catcacaaaa aactggcaca 9240
agcagtgatg gaaatgacat acaagaacaa agtggtgaaa gtgttgagac cagccccagg 9300
agggaaagcc tacatggatg tcataagtcg acgagaccag agaggatccg ggcaggtagt 9360
gacttatgct ctgaacacca tcaccaactt gaaagtccaa ttgatcagaa tggcagaagc 9420
agagatggtg atacatcacc aacatgttca agattgtgat gaatcagttc tgaccaggct 9480
ggaggcatgg ctcactgagc acggatgtga cagactgaag aggatggcgg tgagtggaga 9540
cgactgtgtg gtccggccca tcgatgacag gttcggcctg gccctgtccc atctcaacgc 9600
catgtccaag gttagaaagg acatatctga atggcagcca tcaaaagggt ggaatgattg 9660
ggagaatgtg cccttctgtt cccaccactt ccatgaacta cagctgaagg atggcaggag 9720
gattgtggtg ccttgccgag aacaggacga gctcattggg agaggaaggg tgtctccagg 9780
aaacggctgg atgatcaagg aaacagcttg cctcagcaaa gcctatgcca acatgtggtc 9840
actgatgtat tttcacaaaa gggacatgag gctactgtca ttggctgttt cctcagctgt 9900
tcccacctca tgggttccac aaggacgcac aacatggtcg attcatggga aaggggagtg 9960
gatgaccacg gaagacatgc ttgaggtgtg gaacagagta tggataacca acaacccaca 10020
catgcaggac aagacaatgg tgaaaaaatg gagagatgtc ccttatctaa ccaagagaca 10080
agacaagctg tgcggatcac tgattggaat gaccaatagg gccacctggg cctcccacat 10140
ccatttagtc atccatcgta tccgaacgct gattggacag gagaaataca ctgactacct 10200
aacagtcatg gacaggtatt ctgtggatgc tgacctgcaa ctgggtgagc ttatctgaaa 10260
caccatctaa caggaataac cgggatacaa accacgggtg gagaaccgga ctccccacaa 10320
cctgaaaccg ggatataaac cacggctgga gaaccggact ccgcacttaa aatgaaacag 10380
aaaccgggat aaaaactacg gatggagaac cggactccac acattgagac agaagaagtt 10440
gtcagcccag aaccccacac gagttttgcc actgctaagc tgtgaggcag tgcaggctgg 10500
gacagccgac ctccaggttg cgaaaaacct ggtttctggg acctcccacc ccagagtaaa 10560
aagaacggag cctccgctac caccctccca cgtggtggta gaaagacggg gtctagaggt 10620
tagaggagac cctccaggga acaaatagtg ggaccatatt gacgccaggg aaagaccgga 10680
gtggttctct gcttttcctc cagaggtctg tgagcacagt ttgctcaaga ataagcagac 10740
ctttggatga caaacacaaa accactcgag 10770
<210> 105
<211> 10948
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 105
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttgggaac agagagacgt taatggagtt tgaggaacca 1620
cacgccacga agcagtctgt gatagcattg ggctcacaag agggagctct gcatcaagct 1680
ttggctggag ccattcctgt ggaattttca agcaacactg tcaagttgac gtcgggtcat 1740
ttgaagtgta gagtgaagat ggaaaaattg cagttgaagg gaacaaccta tggcgtctgt 1800
tcaaaggctt tcaagtttct tgggactccc gcagacacag gtcacggcac tgtggtgttg 1860
gaattgcagt acactggcac ggatggacct tgcaaagttc ctatctcgtc agtggcttca 1920
ttgaacgacc taacgccagt gggcagattg gtcactgtca acccttttgt ttcagtggcc 1980
acggccaacg ctaaggtcct gattgaattg gaaccaccct ttggagactc atacatagtg 2040
gtgggcagag gagaacaaca gattaatcac cattggcaca agtctggaag cagcattggc 2100
aaagccttta caaccaccct caaaggagcg cagagactag ccgctctagg agacacagct 2160
tgggactttg gatcagttgg aggggtgttc acctcagttg ggaaggctgt ccatcaagtg 2220
ttcggaggag cattccgctc actgttcgga ggcatgtcct ggataacgca aggattgctg 2280
ggggctctcc tgttgtggat gggcatcaat gctcgtgata ggtccatagc tctcacgttt 2340
ctcgcagttg gaggagttct gctcttcctc tccgtgaacg tgcacgctga cactgggtgt 2400
gccatagaca tcagccggca agagctgaga tgtggaagtg gagtgttcat acacaatgat 2460
gtggaggctt ggatggaccg gtacaagtat taccctgaaa cgccacaagg cctagccaag 2520
atcattcaga aagctcataa ggaaggagtg tgcggtctac gatcagtttc cagactggag 2580
catcaaatgt gggaagcagt gaaggacgag ctgaacactc ttttgaagga gaatggtgtg 2640
gaccttagtg tcgtggttga gaaacaggag ggaatgtaca agtcagcacc taaacgcctc 2700
accgccacca cggaaaaact ggaaattggc tggaaggcct ggggaaagag tattttattt 2760
gcaccagaac tcgccaacaa cacctttgtg gttgatggtc cggagaccaa ggaatgtccg 2820
actcagaatc gcgcttggaa tagcttagaa gtggaggatt ttggatttgg tctcaccagc 2880
actcggatgt tcctgaaggt cagagagagc aacacaactg aatgtgactc gaagatcatt 2940
ggaacggctg tcaagaacaa cttggcgatc cacagtgacc tgtcctattg gattgaaagc 3000
aggctcaatg atacgtggaa gcttgaaagg gcagttctgg gtgaagtcaa atcatgtacg 3060
tggcctgaga cgcatacctt gtggggcgat ggaatccttg agagtgactt gataatacca 3120
gtcacactgg cgggaccacg aagcaatcac aatcggagac ctgggtacaa gacacaaaac 3180
cagggcccat gggacgaagg ccgggtagag attgacttcg attactgccc aggaactacg 3240
gtcaccctga gtgagagctg cggacaccgt ggacctgcca ctcgcaccac cacagagagc 3300
ggaaagttga taacagattg gtgctgcagg agctgcacct taccaccact gcgctaccaa 3360
actgacagcg gctgttggta tggtatggag atcagaccac agagacatga tgaaaagacc 3420
ctcgtgcagt cacaagtgaa tgcttataat gctgatatga ttgacccttt tcagttgggc 3480
cttctggtcg tgttcttggc cacccaggag gtccttcgca agaggtggac agccaagatc 3540
agcatgccag ctatactgat tgctctgcta gtcctggtgt ttgggggcat tacttacact 3600
gatgtgttac gctatgtcat cttggtgggg gcagctttcg cagaatctaa ttcgggagga 3660
gacgtggtac acttggcgct catggcgacc ttcaagatac aaccagtgtt tatggtggca 3720
tcgtttctca aagcgagatg gaccaaccag gagaacattt tgttgatgtt ggcggctgtt 3780
ttctttcaaa tggcttatca cgatgcccgc caaattctgc tctgggagat ccctgatgtg 3840
ttgaattcac tggcggtagc ttggatgata ctgagagcca taacattcac aacgacatca 3900
aacgtggttg ttccgctgct agccctgcta acacccgggc tgagatgctt gaatctggat 3960
gtgtacagga tactgctgtt gatggtcgga ataggcagct tgatcaggga gaagaggagt 4020
gcagctgcaa aaaagaaagg agcaagtctg ctatgcttgg ctctagcctc aacaggactt 4080
ttcaacccca tgatccttgc tgctggactg attgcatgtg atcccaaccg taaacgcgga 4140
tggcccgcaa ctgaagtgat gacagctgtc ggcctaatgt ttgccatcgt cggagggctg 4200
gcagagcttg acattgactc catggccatt ccaatgacta tcgcggggct catgtttgct 4260
gctttcgtga tttctgggaa atcaacagat atgtggattg agagaacggc ggacatttcc 4320
tgggaaagtg atgcagaaat tacaggctcg agcgaaagag ttgatgtgcg gcttgatgat 4380
gatggaaact tccagctcat gaatgatcca ggagcacctt ggaagatatg gatgctcaga 4440
atggtctgtc tcgcgattag tgcgtacacc ccctgggcaa tcttgccctc agtagttgga 4500
ttttggataa ctctccaata cacaaagaga ggaggtgtgt tgtgggacac tccctcacca 4560
aaggagtaca aaaaggggga cacgaccacc ggcgtctaca ggatcatgac tcgtgggctg 4620
ctcggcagtt atcaagcagg agcgggcgtg atggttgaag gtgttttcca caccctttgg 4680
catacaacaa aaggagccgc tttgatgagc ggagagggcc gcctggaccc atactggggc 4740
agtgtcaagg aggatcgact ttgttacgga ggaccctgga aattgcagca caagtggaac 4800
gggcaggatg aggtgcagat gattgtggtg gaacctggca agaacgttaa gaacgtccag 4860
acgaaaccag gggtgttcaa aacacctgaa ggagaaatcg gggccgtgac tttggacttc 4920
cccactggaa catcaggctc accaatagtg gacaaaaacg gtgatgtgat tgggctttat 4980
ggcaatggag tcataatgcc caacggctca tacataagcg cgatagtgca gggtgaaagg 5040
atggatgagc caatcccagc cggattcgaa cctgagatgc tgaggaaaaa acagatcact 5100
gtactggatc tccatcccgg cgccggtaaa acaaggagga ttctgccaca gatcatcaaa 5160
gaggccataa acagaagact gagaacagcc gtgctagcac caaccagggt tgtggctgct 5220
gagatggctg aagcactgag aggactgccc atccggtacc agacatccgc agtgcccaga 5280
gaacataatg gaaatgagat tgttgatgtc atgtgtcatg ctaccctcac ccacaggctg 5340
atgtctcctc acagggtgcc gaactacaac ctgttcgtga tggatgaggc tcatttcacc 5400
gacccagcta gtatcgcagc aagaggttac atttccacaa aggtcgagct aggggaggcg 5460
gcggcaatat tcatgacagc caccccacca ggcacttcag atccattccc agagtccaat 5520
tcaccaattt ccgacttaca gactgagatc ccggatcgag cttggaactc tggatacgaa 5580
tggatcacag aatacaccgg gaagacggtt tggtttgtgc ctagtgtcaa gatggggaat 5640
gagattgccc tttgcctaca acgtgctgga aagaaagtag tccaattgaa cagaaagtcg 5700
tacgagacgg agtacccaaa atgtaagaac gatgattggg actttgttat cacaacagac 5760
atatctgaaa tgggggctaa cttcaaggcg agcagggtga ttgacagccg gaagagtgtg 5820
aaaccaacca tcataacaga aggagaaggg agagtgatcc tgggagaacc atctgcagtg 5880
acagcagcta gtgccgccca gagacgtgga cgtatcggta gaaatccgtc gcaagttggt 5940
gatgagtact gttatggggg gcacacgaat gaagacgact cgaacttcgc ccattggact 6000
gaggcacgaa tcatgctgga caacatcaac atgccaaacg gactgatcgc tcaattctac 6060
caaccagagc gtgagaaggt atataccatg gatggggaat accggctcag aggagaagag 6120
aggaaaaact ttctggaact gttgaggact gcagatctgc cagtttggct ggcttacaag 6180
gttgcagcgg ctggagtgtc ataccacgac cggaggtggt gctttgatgg tcctaggaca 6240
aacacaattt tagaagacaa caacgaagtg gaagtcatca cgaagcttgg tgaaaggaag 6300
attctgaggc cgcgctggat tgacgccagg gtgtactcgg atcaccaggc actaaaggcg 6360
ttcaaggact tcgcctcggg aaaacgttct cagatagggc tcattgaggt tctgggaaag 6420
atgcctgagc acttcatggg gaagacatgg gaagcacttg acaccatgta cgtagtggcc 6480
actgcagaga aaggaggaag agctcacaga atggccctgg aggaactgcc agatgctctt 6540
cagacaattg ccttgattgc cttattgagt gtgatgacca tgggagtatt cttcctcctc 6600
atgcagcgga agggcattgg aaagataggt ttgggaggcg ctgtcttggg agtcgcgacc 6660
tttttctgtt ggatggctga agttccagga acgaagatcg ccggaatgtt gctgctctcc 6720
cttctcttga tgattgtgct aattcctgag ccagagaagc aacgttcgca gacagacaac 6780
cagctagccg tgttcctgat ttgtgtcatg acccttgtga gcgcagtggc agccaacgag 6840
atgggttggc tagataagac caagagtgac ataagcagtt tgtttgggca aagaattgag 6900
gtcaaggaga atttcagcat gggagagttt cttctggact tgaggccggc aacagcctgg 6960
tcactgtacg ctgtgacaac agcggtcctc actccactgc taaagcattt gatcacgtca 7020
gattacatca acacctcatt gacctcaata aacgttcagg caagtgcact attcacactc 7080
gcgcgaggct tccccttcgt cgatgttgga gtgtcggctc tcctgctagc agccggatgc 7140
tggggacaag tcaccctcac cgttacggta acagcggcaa cactcctttt ttgccactat 7200
gcctacatgg ttcccggttg gcaagctgag gcaatgcgct cagcccagcg gcggacagcg 7260
gccggaatca tgaagaacgc tgtagtggat ggcatcgtgg ccacggacgt cccagaatta 7320
gagcgcacca cacccatcat gcagaagaaa gttggacaga tcatgctgat cttggtgtct 7380
ctagctgcag tagtagtgaa cccgtctgtg aagacagtac gagaagccgg aattttgatc 7440
acggccgcag cggtgacgct ttgggagaat ggagcaagct ctgtttggaa cgcaacaact 7500
gccatcggac tctgccacat catgcgtggg ggttggttgt catgtctatc cataacatgg 7560
acactcataa agaacatgga aaaaccagga ctaaaaagag gtggggcaaa aggacgcacc 7620
ttgggagagg tttggaaaga aagactcaac cagatgacaa aagaagagtt cactaggtac 7680
cgcaaagagg ccatcatcga agtcgatcgc tcagcggcaa aacacgccag gaaagaaggc 7740
aatgtcactg gagggcattc agtctctagg ggcacagcaa aactgagatg gctggtcgaa 7800
cggaggtttc tcgaaccggt cggaaaagtg attgaccttg gatgtggaag aggcggttgg 7860
tgttactata tggcaaccca aaaaagagtc caagaagtca gagggtacac aaagggcggt 7920
cccggacatg aagagcccca actagtgcaa agttatggat ggaacattgt caccatgaag 7980
agtggagtgg atgtgttcta cagaccttct gagtgttgtg acaccctcct ttgtgacatc 8040
ggagagtcct cgtcaagtgc tgaggttgaa gagcatagga cgattcgtgt ccttgaaatg 8100
gttgaggact ggctgcaccg agggccaagg gaattttgcg tgaaggtgct ctgcccctac 8160
atgccgaaag tcatagagaa gatggagctg ctccaacgcc ggtatggggg gggactggtc 8220
agaaacccac tctcacggaa ttccacgcac gagatgtatt gggtgagtcg agcttcaggc 8280
aatgtggtac attcagtgaa tatgaccagc caggtgctcc taggaagaat ggaaaaaagg 8340
acctggaagg gaccccaata cgaggaagat gtaaacttgg gaagtggaac cagggcggtg 8400
ggaaaacccc tgctcaactc agacaccagt aaaatcaaga acaggattga acgactcagg 8460
cgtgagtaca gttcgacgtg gcaccacgat gagaaccacc catatagaac ctggaactat 8520
cacggcagtt atgatgtgaa gcccacaggc tccgccagtt cgctggtcaa tggagtggtc 8580
aggctcctct caaaaccatg ggacaccatc acgaatgtta ccaccatggc catgactgac 8640
actactccct tcgggcagca gcgagtgttc aaagagaagg tggacacgaa agctcctgaa 8700
ccgccagaag gagcgaagta cgtgctcaac gagaccacca actggttgtg ggcgtttttg 8760
gccagagaaa aacgtcccag aatgtgctct cgagaggaat tcataagaaa ggtcaacagc 8820
aatgcagctt tgggtgccat gtttgaagag cagaatcaat ggaggagcgc cagagaagca 8880
gttgaagatc caaaattttg ggagatggtg gatgaggagc gcgaggcaca tctgcggggg 8940
gaatgtcaca cttgcattta caacatgatg ggaaagagag agaaaaaacc cggagagttc 9000
ggaaaggcca agggaagcag agccatttgg ttcatgtggc tcggagctcg ctttctggag 9060
ttcgaggctc tgggttttct caatgaagac cactggcttg gaagaaagaa ctcaggagga 9120
ggtgtcgagg gcttgggcct ccaaaaactg ggttacatcc tgcgtgaagt tggcacccgg 9180
cctgggggca agatctatgc tgatgacaca gctggctggg acacccgcat cacgagagct 9240
gacttggaaa atgaagctaa ggtgcttgag ctgcttgatg gggaacatcg gcgtcttgcc 9300
agggccatca ttgagctcac ctatcgtcac aaagttgtga aagtgatgcg cccggctgct 9360
gatggaagaa ccgtcatgga tgttatctcc agagaagatc agagggggag tggacaagtt 9420
gtcacctacg ccctaaacac tttcaccaac ctggccgtcc agctggtgag gatgatggaa 9480
ggggaaggag tgattggccc agatgatgtg gagaaactca caaaagggaa aggacccaaa 9540
gtcaggacct ggctgtttga gaatggggaa gaaagactca gccgcatggc tgtcagtgga 9600
gatgactgtg tggtaaagcc cctggacgat cgctttgcca cctcgctcca cttcctcaat 9660
gctatgtcaa aggttcgcaa agacatccaa gagtggaaac cgtcaactgg atggtatgat 9720
tggcagcagg ttccattttg ctcaaaccat ttcactgaat tgatcatgaa agatggaaga 9780
acactggtgg ttccatgccg aggacaggat gaattggtag gcagagctcg catatctcca 9840
ggggccggat ggaacgtccg cgacactgct tgtctggcta agtcttatgc ccagatgtgg 9900
ctgcttctgt acttccacag aagagacctg cggctcatgg ccaacgccat ttgctccgct 9960
gtccctgtga attgggtccc taccggaaga accacgtggt ccatccatgc aggaggagag 10020
tggatgacaa cagaggacat gttggaggtc tggaaccgtg tttggataga ggagaatgaa 10080
tggatggaag acaaaacccc agtggagaaa tggagtgacg tcccatattc aggaaaacga 10140
gaggacatct ggtgtggcag cctgattggc acaagagccc gagccacgtg ggcagaaaac 10200
atccaggtgg ctatcaacca agtcagagca atcatcggag atgagaagta tgtggattac 10260
atgagttcac taaagagata tgaagacaca actttggttg aggacacagt actgtagata 10320
tttaatcaat tgtaaataga caatataagt atgcataaaa gtgtagtttt atagtagtat 10380
ttagtggtgt tagtgtaaat agttaagaaa attttgagga gaaagtcagg ccgggaagtt 10440
cccgccaccg gaagttgagt agacggtgct gcctgcgact caaccccagg aggactgggt 10500
gaacaaagcc gcgaagtgat ccatgtaagc cctcagaacc gtctcggaag gaggacccca 10560
catgttgtaa cttcaaagcc caatgtcaga ccacgctacg gcgtgctact ctgcggagag 10620
tgcagtctgc gatagtgccc caggaggact gggttaacaa aggcaaatca acgccccacg 10680
cggccctagc cccggtaatg gtgttaacca gggcgaaagg actagaggtt agaggagacc 10740
ccgcggttta aagtgcacgg cccagcctgg ctgaagctgt aggtcagggg aaggactaga 10800
ggttagtgga gaccccgtgc cacaaaacac cacaacaaaa cagcatattg acacctggga 10860
tagactagga gatcttctgc tctgcacaac cagccacacg gcacagtgcg ccgacaatgg 10920
tggctggtgg tgcgagaaca caggatct 10948
<210> 106
<211> 10794
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 106
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc 1620
atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg 1680
ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa 1740
gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact 1800
gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag 1860
ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca 1920
ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt 1980
cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc 2040
aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc 2100
tttggagact catacatagt ggtgggcaga ggagaacaac agattaatca ccattggcac 2160
aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta 2220
gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt 2280
gggaaggctg tccatcaaac aatgatgtgg aggcttggat ggaccggtac aagtattacc 2340
ctgaaacgcc acaaggccta gccaagatca ttcagaaagc tcataaggaa ggagtgtgcg 2400
gtctacgatc agtttccaga ctggagcatc aaatgtggga agcagtgaag gacgagctga 2460
acactctttt gaaggagaat ggtgtggacc ttagtgtcgt ggttgagaaa caggagggaa 2520
tgtacaagtc agcacctaaa cgcctcaccg ccaccacgga aaaactggaa attggctgga 2580
aggcctgggg aaagagtatt ttatttgcac cagaactcgc caacaacacc tttgtggttg 2640
atggtccgga gaccaaggaa tgtccgactc agaatcgcgc ttggaatagc ttagaagtgg 2700
aggattttgg atttggtctc accagcactc ggatgttcct gaaggtcaga gagagcaaca 2760
caactgaatg tgactcgaag atcattggaa cggctgtcaa gaacaacttg gcgatccaca 2820
gtgacctgtc ctattggatt gaaagcaggc tcaatgatac gtggaagctt gaaagggcag 2880
ttctgggtga agtcaaatca tgtacgtggc ctgagacgca taccttgtgg ggcgatggaa 2940
tccttgagag tgacttgata ataccagtca cactggcggg accacgaagc aatcacaatc 3000
ggagacctgg gtacaagaca caaaaccagg gcccatggga cgaaggccgg gtagagattg 3060
acttcgatta ctgcccagga actacggtca ccctgagtga gagctgcgga caccgtggac 3120
ctgccactcg caccaccaca gagagcggaa agttgataac agattggtgc tgcaggagct 3180
gcaccttacc accactgcgc taccaaactg acagcggctg ttggtatggt atggagatca 3240
gaccacagag acatgatgaa aagaccctcg tgcagtcaca agtgaatgct tataatgctg 3300
atatgattga cccttttcag ttgggccttc tggtcgtgtt cttggccacc caggaggtcc 3360
ttcgcaagag gtggacagcc aagatcagca tgccagctat actgattgct ctgctagtcc 3420
tggtgtttgg gggcattact tacactgatg tgttacgcta tgtcatcttg gtgggggcag 3480
ctttcgcaga atctaattcg ggaggagacg tggtacactt ggcgctcatg gcgaccttca 3540
agatacaacc agtgtttatg gtggcatcgt ttctcaaagc gagatggacc aaccaggaga 3600
acattttgtt gatgttggcg gctgttttct ttcaaatggc ttatcacgat gcccgccaaa 3660
ttctgctctg ggagatccct gatgtgttga attcactggc ggtagcttgg atgatactga 3720
gagccataac attcacaacg acatcaaacg tggttgttcc gctgctagcc ctgctaacac 3780
ccgggctgag atgcttgaat ctggatgtgt acaggatact gctgttgatg gtcggaatag 3840
gcagcttgat cagggagaag aggagtgcag ctgcaaaaaa gaaaggagca agtctgctat 3900
gcttggctct agcctcaaca ggacttttca accccatgat ccttgctgct ggactgattg 3960
catgtgatcc caaccgtaaa cgcggatggc ccgcaactga agtgatgaca gctgtcggcc 4020
taatgtttgc catcgtcgga gggctggcag agcttgacat tgactccatg gccattccaa 4080
tgactatcgc ggggctcatg tttgctgctt tcgtgatttc tgggaaatca acagatatgt 4140
ggattgagag aacggcggac atttcctggg aaagtgatgc agaaattaca ggctcgagcg 4200
aaagagttga tgtgcggctt gatgatgatg gaaacttcca gctcatgaat gatccaggag 4260
caccttggaa gatatggatg ctcagaatgg tctgtctcgc gattagtgcg tacaccccct 4320
gggcaatctt gccctcagta gttggatttt ggataactct ccaatacaca aagagaggag 4380
gtgtgttgtg ggacactccc tcaccaaagg agtacaaaaa gggggacacg accaccggcg 4440
tctacaggat catgactcgt gggctgctcg gcagttatca agcaggagcg ggcgtgatgg 4500
ttgaaggtgt tttccacacc ctttggcata caacaaaagg agccgctttg atgagcggag 4560
agggccgcct ggacccatac tggggcagtg tcaaggagga tcgactttgt tacggaggac 4620
cctggaaatt gcagcacaag tggaacgggc aggatgaggt gcagatgatt gtggtggaac 4680
ctggcaagaa cgttaagaac gtccagacga aaccaggggt gttcaaaaca cctgaaggag 4740
aaatcggggc cgtgactttg gacttcccca ctggaacatc aggctcacca atagtggaca 4800
aaaacggtga tgtgattggg ctttatggca atggagtcat aatgcccaac ggctcataca 4860
taagcgcgat agtgcagggt gaaaggatgg atgagccaat cccagccgga ttcgaacctg 4920
agatgctgag gaaaaaacag atcactgtac tggatctcca tcccggcgcc ggtaaaacaa 4980
ggaggattct gccacagatc atcaaagagg ccataaacag aagactgaga acagccgtgc 5040
tagcaccaac cagggttgtg gctgctgaga tggctgaagc actgagagga ctgcccatcc 5100
ggtaccagac atccgcagtg cccagagaac ataatggaaa tgagattgtt gatgtcatgt 5160
gtcatgctac cctcacccac aggctgatgt ctcctcacag ggtgccgaac tacaacctgt 5220
tcgtgatgga tgaggctcat ttcaccgacc cagctagtat cgcagcaaga ggttacattt 5280
ccacaaaggt cgagctaggg gaggcggcgg caatattcat gacagccacc ccaccaggca 5340
cttcagatcc attcccagag tccaattcac caatttccga cttacagact gagatcccgg 5400
atcgagcttg gaactctgga tacgaatgga tcacagaata caccgggaag acggtttggt 5460
ttgtgcctag tgtcaagatg gggaatgaga ttgccctttg cctacaacgt gctggaaaga 5520
aagtagtcca attgaacaga aagtcgtacg agacggagta cccaaaatgt aagaacgatg 5580
attgggactt tgttatcaca acagacatat ctgaaatggg ggctaacttc aaggcgagca 5640
gggtgattga cagccggaag agtgtgaaac caaccatcat aacagaagga gaagggagag 5700
tgatcctggg agaaccatct gcagtgacag cagctagtgc cgcccagaga cgtggacgta 5760
tcggtagaaa tccgtcgcaa gttggtgatg agtactgtta tggggggcac acgaatgaag 5820
acgactcgaa cttcgcccat tggactgagg cacgaatcat gctggacaac atcaacatgc 5880
caaacggact gatcgctcaa ttctaccaac cagagcgtga gaaggtatat accatggatg 5940
gggaataccg gctcagagga gaagagagga aaaactttct ggaactgttg aggactgcag 6000
atctgccagt ttggctggct tacaaggttg cagcggctgg agtgtcatac cacgaccgga 6060
ggtggtgctt tgatggtcct aggacaaaca caattttaga agacaacaac gaagtggaag 6120
tcatcacgaa gcttggtgaa aggaagattc tgaggccgcg ctggattgac gccagggtgt 6180
actcggatca ccaggcacta aaggcgttca aggacttcgc ctcgggaaaa cgttctcaga 6240
tagggctcat tgaggttctg ggaaagatgc ctgagcactt catggggaag acatgggaag 6300
cacttgacac catgtacgta gtggccactg cagagaaagg aggaagagct cacagaatgg 6360
ccctggagga actgccagat gctcttcaga caattgcctt gattgcctta ttgagtgtga 6420
tgaccatggg agtattcttc ctcctcatgc agcggaaggg cattggaaag ataggtttgg 6480
gaggcgctgt cttgggagtc gcgacctttt tctgttggat ggctgaagtt ccaggaacga 6540
agatcgccgg aatgttgctg ctctcccttc tcttgatgat tgtgctaatt cctgagccag 6600
agaagcaacg ttcgcagaca gacaaccagc tagccgtgtt cctgatttgt gtcatgaccc 6660
ttgtgagcgc agtggcagcc aacgagatgg gttggctaga taagaccaag agtgacataa 6720
gcagtttgtt tgggcaaaga attgaggtca aggagaattt cagcatggga gagtttcttc 6780
tggacttgag gccggcaaca gcctggtcac tgtacgctgt gacaacagcg gtcctcactc 6840
cactgctaaa gcatttgatc acgtcagatt acatcaacac ctcattgacc tcaataaacg 6900
ttcaggcaag tgcactattc acactcgcgc gaggcttccc cttcgtcgat gttggagtgt 6960
cggctctcct gctagcagcc ggatgctggg gacaagtcac cctcaccgtt acggtaacag 7020
cggcaacact ccttttttgc cactatgcct acatggttcc cggttggcaa gctgaggcaa 7080
tgcgctcagc ccagcggcgg acagcggccg gaatcatgaa gaacgctgta gtggatggca 7140
tcgtggccac ggacgtccca gaattagagc gcaccacacc catcatgcag aagaaagttg 7200
gacagatcat gctgatcttg gtgtctctag ctgcagtagt agtgaacccg tctgtgaaga 7260
cagtacgaga agccggaatt ttgatcacgg ccgcagcggt gacgctttgg gagaatggag 7320
caagctctgt ttggaacgca acaactgcca tcggactctg ccacatcatg cgtgggggtt 7380
ggttgtcatg tctatccata acatggacac tcataaagaa catggaaaaa ccaggactaa 7440
aaagaggtgg ggcaaaagga cgcaccttgg gagaggtttg gaaagaaaga ctcaaccaga 7500
tgacaaaaga agagttcact aggtaccgca aagaggccat catcgaagtc gatcgctcag 7560
cggcaaaaca cgccaggaaa gaaggcaatg tcactggagg gcattcagtc tctaggggca 7620
cagcaaaact gagatggctg gtcgaacgga ggtttctcga accggtcgga aaagtgattg 7680
accttggatg tggaagaggc ggttggtgtt actatatggc aacccaaaaa agagtccaag 7740
aagtcagagg gtacacaaag ggcggtcccg gacatgaaga gccccaacta gtgcaaagtt 7800
atggatggaa cattgtcacc atgaagagtg gagtggatgt gttctacaga ccttctgagt 7860
gttgtgacac cctcctttgt gacatcggag agtcctcgtc aagtgctgag gttgaagagc 7920
ataggacgat tcgtgtcctt gaaatggttg aggactggct gcaccgaggg ccaagggaat 7980
tttgcgtgaa ggtgctctgc ccctacatgc cgaaagtcat agagaagatg gagctgctcc 8040
aacgccggta tgggggggga ctggtcagaa acccactctc acggaattcc acgcacgaga 8100
tgtattgggt gagtcgagct tcaggcaatg tggtacattc agtgaatatg accagccagg 8160
tgctcctagg aagaatggaa aaaaggacct ggaagggacc ccaatacgag gaagatgtaa 8220
acttgggaag tggaaccagg gcggtgggaa aacccctgct caactcagac accagtaaaa 8280
tcaagaacag gattgaacga ctcaggcgtg agtacagttc gacgtggcac cacgatgaga 8340
accacccata tagaacctgg aactatcacg gcagttatga tgtgaagccc acaggctccg 8400
ccagttcgct ggtcaatgga gtggtcaggc tcctctcaaa accatgggac accatcacga 8460
atgttaccac catggccatg actgacacta ctcccttcgg gcagcagcga gtgttcaaag 8520
agaaggtgga cacgaaagct cctgaaccgc cagaaggagc gaagtacgtg ctcaacgaga 8580
ccaccaactg gttgtgggcg tttttggcca gagaaaaacg tcccagaatg tgctctcgag 8640
aggaattcat aagaaaggtc aacagcaatg cagctttggg tgccatgttt gaagagcaga 8700
atcaatggag gagcgccaga gaagcagttg aagatccaaa attttgggag atggtggatg 8760
aggagcgcga ggcacatctg cggggggaat gtcacacttg catttacaac atgatgggaa 8820
agagagagaa aaaacccgga gagttcggaa aggccaaggg aagcagagcc atttggttca 8880
tgtggctcgg agctcgcttt ctggagttcg aggctctggg ttttctcaat gaagaccact 8940
ggcttggaag aaagaactca ggaggaggtg tcgagggctt gggcctccaa aaactgggtt 9000
acatcctgcg tgaagttggc acccggcctg ggggcaagat ctatgctgat gacacagctg 9060
gctgggacac ccgcatcacg agagctgact tggaaaatga agctaaggtg cttgagctgc 9120
ttgatgggga acatcggcgt cttgccaggg ccatcattga gctcacctat cgtcacaaag 9180
ttgtgaaagt gatgcgcccg gctgctgatg gaagaaccgt catggatgtt atctccagag 9240
aagatcagag ggggagtgga caagttgtca cctacgccct aaacactttc accaacctgg 9300
ccgtccagct ggtgaggatg atggaagggg aaggagtgat tggcccagat gatgtggaga 9360
aactcacaaa agggaaagga cccaaagtca ggacctggct gtttgagaat ggggaagaaa 9420
gactcagccg catggctgtc agtggagatg actgtgtggt aaagcccctg gacgatcgct 9480
ttgccacctc gctccacttc ctcaatgcta tgtcaaaggt tcgcaaagac atccaagagt 9540
ggaaaccgtc aactggatgg tatgattggc agcaggttcc attttgctca aaccatttca 9600
ctgaattgat catgaaagat ggaagaacac tggtggttcc atgccgagga caggatgaat 9660
tggtaggcag agctcgcata tctccagggg ccggatggaa cgtccgcgac actgcttgtc 9720
tggctaagtc ttatgcccag atgtggctgc ttctgtactt ccacagaaga gacctgcggc 9780
tcatggccaa cgccatttgc tccgctgtcc ctgtgaattg ggtccctacc ggaagaacca 9840
cgtggtccat ccatgcagga ggagagtgga tgacaacaga ggacatgttg gaggtctgga 9900
accgtgtttg gatagaggag aatgaatgga tggaagacaa aaccccagtg gagaaatgga 9960
gtgacgtccc atattcagga aaacgagagg acatctggtg tggcagcctg attggcacaa 10020
gagcccgagc cacgtgggca gaaaacatcc aggtggctat caaccaagtc agagcaatca 10080
tcggagatga gaagtatgtg gattacatga gttcactaaa gagatatgaa gacacaactt 10140
tggttgagga cacagtactg tagatattta atcaattgta aatagacaat ataagtatgc 10200
ataaaagtgt agttttatag tagtatttag tggtgttagt gtaaatagtt aagaaaattt 10260
tgaggagaaa gtcaggccgg gaagttcccg ccaccggaag ttgagtagac ggtgctgcct 10320
gcgactcaac cccaggagga ctgggtgaac aaagccgcga agtgatccat gtaagccctc 10380
agaaccgtct cggaaggagg accccacatg ttgtaacttc aaagcccaat gtcagaccac 10440
gctacggcgt gctactctgc ggagagtgca gtctgcgata gtgccccagg aggactgggt 10500
taacaaaggc aaatcaacgc cccacgcggc cctagccccg gtaatggtgt taaccagggc 10560
gaaaggacta gaggttagag gagaccccgc ggtttaaagt gcacggccca gcctggctga 10620
agctgtaggt caggggaagg actagaggtt agtggagacc ccgtgccaca aaacaccaca 10680
acaaaacagc atattgacac ctgggataga ctaggagatc ttctgctctg cacaaccagc 10740
cacacggcac agtgcgccga caatggtggc tggtggtgcg agaacacagg atct 10794
<210> 107
<211> 10978
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 107
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc 1620
atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg 1680
ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa 1740
gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact 1800
gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag 1860
ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca 1920
ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt 1980
cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc 2040
aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc 2100
tttggagact catacatagt ggtgggcaga ggagaacaac agattaatca ccattggcac 2160
aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta 2220
gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt 2280
gggaaggctg tccatcaagt gttcggagga gcattccgct cactgttcgg aggcatgtcc 2340
tggataacgc aaggattgct gggggctctc ctgttgtgga tgggcatcaa tgctcgtgat 2400
aggtccatag ctctcacgtt tctcgcagtt ggaggagttc tgctcttcct ctccgtgaac 2460
gtgcacgctg acactgggtg tgccatagac atcagccggc aagagctgag atgtggaagt 2520
ggagtgttca tacacaatga tgtggaggct tggatggacc ggtacaagta ttaccctgaa 2580
acgccacaag gcctagccaa gatcattcag aaagctcata aggaaggagt gtgcggtcta 2640
cgatcagttt ccagactgga gcatcaaatg tgggaagcag tgaaggacga gctgaacact 2700
cttttgaagg agaatggtgt ggaccttagt gtcgtggttg agaaacagga gggaatgtac 2760
aagtcagcac ctaaacgcct caccgccacc acggaaaaac tggaaattgg ctggaaggcc 2820
tggggaaaga gtattttatt tgcaccagaa ctcgccaaca acacctttgt ggttgatggt 2880
ccggagacca aggaatgtcc gactcagaat cgcgcttgga atagcttaga agtggaggat 2940
tttggatttg gtctcaccag cactcggatg ttcctgaagg tcagagagag caacacaact 3000
gaatgtgact cgaagatcat tggaacggct gtcaagaaca acttggcgat ccacagtgac 3060
ctgtcctatt ggattgaaag caggctcaat gatacgtgga agcttgaaag ggcagttctg 3120
ggtgaagtca aatcatgtac gtggcctgag acgcatacct tgtggggcga tggaatcctt 3180
gagagtgact tgataatacc agtcacactg gcgggaccac gaagcaatca caatcggaga 3240
cctgggtaca agacacaaaa ccagggccca tgggacgaag gccgggtaga gattgacttc 3300
gattactgcc caggaactac ggtcaccctg agtgagagct gcggacaccg tggacctgcc 3360
actcgcacca ccacagagag cggaaagttg ataacagatt ggtgctgcag gagctgcacc 3420
ttaccaccac tgcgctacca aactgacagc ggctgttggt atggtatgga gatcagacca 3480
cagagacatg atgaaaagac cctcgtgcag tcacaagtga atgcttataa tgctgatatg 3540
attgaccctt ttcagttggg ccttctggtc gtgttcttgg ccacccagga ggtccttcgc 3600
aagaggtgga cagccaagat cagcatgcca gctatactga ttgctctgct agtcctggtg 3660
tttgggggca ttacttacac tgatgtgtta cgctatgtca tcttggtggg ggcagctttc 3720
gcagaatcta attcgggagg agacgtggta cacttggcgc tcatggcgac cttcaagata 3780
caaccagtgt ttatggtggc atcgtttctc aaagcgagat ggaccaacca ggagaacatt 3840
ttgttgatgt tggcggctgt tttctttcaa atggcttatc acgatgcccg ccaaattctg 3900
ctctgggaga tccctgatgt gttgaattca ctggcggtag cttggatgat actgagagcc 3960
ataacattca caacgacatc aaacgtggtt gttccgctgc tagccctgct aacacccggg 4020
ctgagatgct tgaatctgga tgtgtacagg atactgctgt tgatggtcgg aataggcagc 4080
ttgatcaggg agaagaggag tgcagctgca aaaaagaaag gagcaagtct gctatgcttg 4140
gctctagcct caacaggact tttcaacccc atgatccttg ctgctggact gattgcatgt 4200
gatcccaacc gtaaacgcgg atggcccgca actgaagtga tgacagctgt cggcctaatg 4260
tttgccatcg tcggagggct ggcagagctt gacattgact ccatggccat tccaatgact 4320
atcgcggggc tcatgtttgc tgctttcgtg atttctggga aatcaacaga tatgtggatt 4380
gagagaacgg cggacatttc ctgggaaagt gatgcagaaa ttacaggctc gagcgaaaga 4440
gttgatgtgc ggcttgatga tgatggaaac ttccagctca tgaatgatcc aggagcacct 4500
tggaagatat ggatgctcag aatggtctgt ctcgcgatta gtgcgtacac cccctgggca 4560
atcttgccct cagtagttgg attttggata actctccaat acacaaagag aggaggtgtg 4620
ttgtgggaca ctccctcacc aaaggagtac aaaaaggggg acacgaccac cggcgtctac 4680
aggatcatga ctcgtgggct gctcggcagt tatcaagcag gagcgggcgt gatggttgaa 4740
ggtgttttcc acaccctttg gcatacaaca aaaggagccg ctttgatgag cggagagggc 4800
cgcctggacc catactgggg cagtgtcaag gaggatcgac tttgttacgg aggaccctgg 4860
aaattgcagc acaagtggaa cgggcaggat gaggtgcaga tgattgtggt ggaacctggc 4920
aagaacgtta agaacgtcca gacgaaacca ggggtgttca aaacacctga aggagaaatc 4980
ggggccgtga ctttggactt ccccactgga acatcaggct caccaatagt ggacaaaaac 5040
ggtgatgtga ttgggcttta tggcaatgga gtcataatgc ccaacggctc atacataagc 5100
gcgatagtgc agggtgaaag gatggatgag ccaatcccag ccggattcga acctgagatg 5160
ctgaggaaaa aacagatcac tgtactggat ctccatcccg gcgccggtaa aacaaggagg 5220
attctgccac agatcatcaa agaggccata aacagaagac tgagaacagc cgtgctagca 5280
ccaaccaggg ttgtggctgc tgagatggct gaagcactga gaggactgcc catccggtac 5340
cagacatccg cagtgcccag agaacataat ggaaatgaga ttgttgatgt catgtgtcat 5400
gctaccctca cccacaggct gatgtctcct cacagggtgc cgaactacaa cctgttcgtg 5460
atggatgagg ctcatttcac cgacccagct agtatcgcag caagaggtta catttccaca 5520
aaggtcgagc taggggaggc ggcggcaata ttcatgacag ccaccccacc aggcacttca 5580
gatccattcc cagagtccaa ttcaccaatt tccgacttac agactgagat cccggatcga 5640
gcttggaact ctggatacga atggatcaca gaatacaccg ggaagacggt ttggtttgtg 5700
cctagtgtca agatggggaa tgagattgcc ctttgcctac aacgtgctgg aaagaaagta 5760
gtccaattga acagaaagtc gtacgagacg gagtacccaa aatgtaagaa cgatgattgg 5820
gactttgtta tcacaacaga catatctgaa atgggggcta acttcaaggc gagcagggtg 5880
attgacagcc ggaagagtgt gaaaccaacc atcataacag aaggagaagg gagagtgatc 5940
ctgggagaac catctgcagt gacagcagct agtgccgccc agagacgtgg acgtatcggt 6000
agaaatccgt cgcaagttgg tgatgagtac tgttatgggg ggcacacgaa tgaagacgac 6060
tcgaacttcg cccattggac tgaggcacga atcatgctgg acaacatcaa catgccaaac 6120
ggactgatcg ctcaattcta ccaaccagag cgtgagaagg tatataccat ggatggggaa 6180
taccggctca gaggagaaga gaggaaaaac tttctggaac tgttgaggac tgcagatctg 6240
ccagtttggc tggcttacaa ggttgcagcg gctggagtgt cataccacga ccggaggtgg 6300
tgctttgatg gtcctaggac aaacacaatt ttagaagaca acaacgaagt ggaagtcatc 6360
acgaagcttg gtgaaaggaa gattctgagg ccgcgctgga ttgacgccag ggtgtactcg 6420
gatcaccagg cactaaaggc gttcaaggac ttcgcctcgg gaaaacgttc tcagataggg 6480
ctcattgagg ttctgggaaa gatgcctgag cacttcatgg ggaagacatg ggaagcactt 6540
gacaccatgt acgtagtggc cactgcagag aaaggaggaa gagctcacag aatggccctg 6600
gaggaactgc cagatgctct tcagacaatt gccttgattg ccttattgag tgtgatgacc 6660
atgggagtat tcttcctcct catgcagcgg aagggcattg gaaagatagg tttgggaggc 6720
gctgtcttgg gagtcgcgac ctttttctgt tggatggctg aagttccagg aacgaagatc 6780
gccggaatgt tgctgctctc ccttctcttg atgattgtgc taattcctga gccagagaag 6840
caacgttcgc agacagacaa ccagctagcc gtgttcctga tttgtgtcat gacccttgtg 6900
agcgcagtgg cagccaacga gatgggttgg ctagataaga ccaagagtga cataagcagt 6960
ttgtttgggc aaagaattga ggtcaaggag aatttcagca tgggagagtt tcttctggac 7020
ttgaggccgg caacagcctg gtcactgtac gctgtgacaa cagcggtcct cactccactg 7080
ctaaagcatt tgatcacgtc agattacatc aacacctcat tgacctcaat aaacgttcag 7140
gcaagtgcac tattcacact cgcgcgaggc ttccccttcg tcgatgttgg agtgtcggct 7200
ctcctgctag cagccggatg ctggggacaa gtcaccctca ccgttacggt aacagcggca 7260
acactccttt tttgccacta tgcctacatg gttcccggtt ggcaagctga ggcaatgcgc 7320
tcagcccagc ggcggacagc ggccggaatc atgaagaacg ctgtagtgga tggcatcgtg 7380
gccacggacg tcccagaatt agagcgcacc acacccatca tgcagaagaa agttggacag 7440
atcatgctga tcttggtgtc tctagctgca gtagtagtga acccgtctgt gaagacagta 7500
cgagaagccg gaattttgat cacggccgca gcggtgacgc tttgggagaa tggagcaagc 7560
tctgtttgga acgcaacaac tgccatcgga ctctgccaca tcatgcgtgg gggttggttg 7620
tcatgtctat ccataacatg gacactcata aagaacatgg aaaaaccagg actaaaaaga 7680
ggtggggcaa aaggacgcac cttgggagag gtttggaaag aaagactcaa ccagatgaca 7740
aaagaagagt tcactaggta ccgcaaagag gccatcatcg aagtcgatcg ctcagcggca 7800
aaacacgcca ggaaagaagg caatgtcact ggagggcatt cagtctctag gggcacagca 7860
aaactgagat ggctggtcga acggaggttt ctcgaaccgg tcggaaaagt gattgacctt 7920
ggatgtggaa gaggcggttg gtgttactat atggcaaccc aaaaaagagt ccaagaagtc 7980
agagggtaca caaagggcgg tcccggacat gaagagcccc aactagtgca aagttatgga 8040
tggaacattg tcaccatgaa gagtggagtg gatgtgttct acagaccttc tgagtgttgt 8100
gacaccctcc tttgtgacat cggagagtcc tcgtcaagtg ctgaggttga agagcatagg 8160
acgattcgtg tccttgaaat ggttgaggac tggctgcacc gagggccaag ggaattttgc 8220
gtgaaggtgc tctgccccta catgccgaaa gtcatagaga agatggagct gctccaacgc 8280
cggtatgggg ggggactggt cagaaaccca ctctcacgga attccacgca cgagatgtat 8340
tgggtgagtc gagcttcagg caatgtggta cattcagtga atatgaccag ccaggtgctc 8400
ctaggaagaa tggaaaaaag gacctggaag ggaccccaat acgaggaaga tgtaaacttg 8460
ggaagtggaa ccagggcggt gggaaaaccc ctgctcaact cagacaccag taaaatcaag 8520
aacaggattc catatagaac ctggaactat cacggcagtt atgatgtgaa gcccacaggc 8580
tccgccagtt cgctggtcaa tggagtggtc aggctcctct caaaaccatg ggacaccatc 8640
acgaatgtta ccaccatggc catgactgac actactccct tcgggcagca gcgagtgttc 8700
aaagagaagg tggacacgaa agctcctgaa ccgccagaag gagcgaagta cgtgctcaac 8760
gagaccacca actggttgtg ggcgtttttg gccagagaaa aacgtcccag aatgtgctct 8820
cgagaggaat tcataagaaa ggtcaacagc aatgcagctt tgggtgccat gtttgaagag 8880
cagaatcaat ggaggagcgc cagagaagca gttgaagatc caaaattttg ggagatggtg 8940
gatgaggagc gcgaggcaca tctgcggggg gaatgtcaca cttgcattta caacatgatg 9000
ggaaagagag agaaaaaacc cggagagttc ggaaaggcca agggaagcag agccatttgg 9060
ttcatgtggc tcggagctcg ctttctggag ttcgaggctc tgggttttct caatgaagac 9120
cactggcttg gaagaaagaa ctcaggagga ggtgtcgagg gcttgggcct ccaaaaactg 9180
ggttacatcc tgcgtgaagt tggcacccgg cctgggggca agatctatgc tgatgacaca 9240
gctggctggg acacccgcat cacgagagct gacttggaaa atgaagctaa ggtgcttgag 9300
ctgcttgatg gggaacatcg gcgtcttgcc agggccatca ttgagctcac ctatcgtcac 9360
aaagttgtga aagtgatgcg cccggctgct gatggaagaa ccgtcatgga tgttatctcc 9420
agagaagatc agagggggag tggacaagtt gtcacctacg ccctaaacac tttcaccaac 9480
ctggccgtcc agctggtgag gatgatggaa ggggaaggag tgattggccc agatgatgtg 9540
gagaaactca caaaagggaa aggacccaaa gtcaggacct ggctgtttga gaatggggaa 9600
gaaagactca gccgcatggc tgtcagtgga gatgactgtg tggtaaagcc cctggacgat 9660
cgctttgcca cctcgctcca cttcctcaat gctatgtcaa aggttcgcaa agacatccaa 9720
gagtggaaac cgtcaactgg atggtatgat tggcagcagg ttccattttg ctcaaaccat 9780
ttcactgaat tgatcatgaa agatggaaga acactggtgg ttccatgccg aggacaggat 9840
gaattggtag gcagagctcg catatctcca ggggccggat ggaacgtccg cgacactgct 9900
tgtctggcta agtcttatgc ccagatgtgg ctgcttctgt acttccacag aagagacctg 9960
cggctcatgg ccaacgccat ttgctccgct gtccctgtga attgggtccc taccggaaga 10020
accacgtggt ccatccatgc aggaggagag tggatgacaa cagaggacat gttggaggtc 10080
tggaaccgtg tttggataga ggagaatgaa tggatggaag acaaaacccc agtggagaaa 10140
tggagtgacg tcccatattc aggaaaacga gaggacatct ggtgtggcag cctgattggc 10200
acaagagccc gagccacgtg ggcagaaaac atccaggtgg ctatcaacca agtcagagca 10260
atcatcggag atgagaagta tgtggattac atgagttcac taaagagata tgaagacaca 10320
actttggttg aggacacagt actgtagata tttaatcaat tgtaaataga caatataagt 10380
atgcataaaa gtgtagtttt atagtagtat ttagtggtgt tagtgtaaat agttaagaaa 10440
attttgagga gaaagtcagg ccgggaagtt cccgccaccg gaagttgagt agacggtgct 10500
gcctgcgact caaccccagg aggactgggt gaacaaagcc gcgaagtgat ccatgtaagc 10560
cctcagaacc gtctcggaag gaggacccca catgttgtaa cttcaaagcc caatgtcaga 10620
ccacgctacg gcgtgctact ctgcggagag tgcagtctgc gatagtgccc caggaggact 10680
gggttaacaa aggcaaatca acgccccacg cggccctagc cccggtaatg gtgttaacca 10740
gggcgaaagg actagaggtt agaggagacc ccgcggttta aagtgcacgg cccagcctgg 10800
ctgaagctgt aggtcagggg aaggactaga ggttagtgga gaccccgtgc cacaaaacac 10860
cacaacaaaa cagcatattg acacctggga tagactagga gatcttctgc tctgcacaac 10920
cagccacacg gcacagtgcg ccgacaatgg tggctggtgg tgcgagaaca caggatct 10978
<210> 108
<211> 10947
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 108
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc 1620
atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg 1680
ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa 1740
gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact 1800
gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag 1860
ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca 1920
ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt 1980
cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc 2040
aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc 2100
tttggagact catacatagt ggtgggcaga ggagaacaac agattaatca ccattggcac 2160
aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta 2220
gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt 2280
gggaaggctg tccatcaagt gttcggagga gcattccgct cactgttcgg aggcatgtcc 2340
tggataacgc aaggattgct gggggctctc ctgttgtgga tgggcatcaa tgctcgtgat 2400
aggtccatag ctctcacgtt tctcgcagtt ggaggagttc tgctcttcct ctccgtgaac 2460
gtgcacgctg acactgggtg tgccatagac atcagccggc aagagctgag atgtggaagt 2520
ggagtgttca tacacaatga tgtggaggct tggatggacc ggtacaagta ttaccctgaa 2580
acgccacaag gcctagccaa gatcattcag aaagctcata aggaaggagt gtgcggtcta 2640
cgatcagttt ccagactgga gcatcaaatg tgggaagcag tgaaggacga gctgaacact 2700
cttttgaagg agaatggtgt ggaccttagt gtcgtggttg agaaacagga gggaatgtac 2760
aagtcagcac ctaaacgcct caccgccacc acggaaaaac tggaaattgg ctggaaggcc 2820
tggggaaaga gtattttatt tgcaccagaa ctcgccaaca acacctttgt ggttgatggt 2880
ccggagacca aggaatgtcc gactcagaat cgcgcttgga atagcttaga agtggaggat 2940
tttggatttg gtctcaccag cactcggatg ttcctgaagg tcagagagag caacacaact 3000
gaatgtgact cgaagatcat tggaacggct gtcaagaaca acttggcgat ccacagtgac 3060
ctgtcctatt ggattgaaag caggctcaat gatacgtgga agcttgaaag ggcagttctg 3120
ggtgaagtca aatcatgtac gtggcctgag acgcatacct tgtggggcga tggaatcctt 3180
gagagtgact tgataatacc agtcacactg gcgggaccac gaagcaatca caatcggaga 3240
cctgggtaca agacacaaaa ccagggccca tgggacgaag gccgggtaga gattgacttc 3300
gattactgcc caggaactac ggtcaccctg agtgagagct gcggacaccg tggacctgcc 3360
actcgcacca ccacagagag cggaaagttg ataacagatt ggtgctgcag gagctgcacc 3420
ttaccaccac tgcgctacca aactgacagc ggctgttggt atggtatgga gatcagacca 3480
cagagacatg atgaaaagac cctcgtgcag tcacaagtga atgcttataa tgctgatatg 3540
attgaccctt ttcagttggg ccttctggtc gtgttcttgg ccacccagga ggtccttcgc 3600
aagaggtgga cagccaagat cagcatgcca gctatactga ttgctctgct agtcctggtg 3660
tttgggggca ttacttacac tgatgtgtta cgctatgtca tcttggtggg ggcagctttc 3720
gcagaatcta attcgggagg agacgtggta cacttggcgc tcatggcgac cttcaagata 3780
caaccagtgt ttatggtggc atcgtttctc aaagcgagat ggaccaacca ggagaacatt 3840
ttgttgatgt tggcggctgt tttctttcaa atggcttatc acgatgcccg ccaaattctg 3900
ctctgggaga tccctgatgt gttgaattca ctggcggtag cttggatgat actgagagcc 3960
ataacattca caacgacatc aaacgtggtt gttccgctgc tagccctgct aacacccggg 4020
ctgagatgct tgaatctgga tgtgtacagg atactgctgt tgatggtcgg aataggcagc 4080
ttgatcaggg agaagaggag tgcagctgca aaaaagaaag gagcaagtct gctatgcttg 4140
gctctagcct caacaggact tttcaacccc atgatccttg ctgctggact gattgcatgt 4200
gatcccaacc gtaaacgcgg atggcccgca actgaagtga tgacagctgt cggcctaatg 4260
tttgccatcg tcggagggct ggcagagctt gacattgact ccatggccat tccaatgact 4320
atcgcggggc tcatgtttgc tgctttcgtg atttctggga aatcaacaga tatgtggatt 4380
gagagaacgg cggacatttc ctgggaaagt gatgcagaaa ttacaggctc gagcgaaaga 4440
gttgatgtgc ggcttgatga tgatggaaac ttccagctca tgaatgatcc aggagcacct 4500
tggaagatat ggatgctcag aatggtctgt ctcgcgatta gtgcgtacac cccctgggca 4560
atcttgccct cagtagttgg attttggata actctccaat acacaaagag aggaggtgtg 4620
ttgtgggaca ctccctcacc aaaggagtac aaaaaggggg acacgaccac cggcgtctac 4680
aggatcatga ctcgtgggct gctcggcagt tatcaagcag gagcgggcgt gatggttgaa 4740
ggtgttttcc acaccctttg gcatacaaca aaaggagccg ctttgatgag cggagagggc 4800
cgcctggacc catactgggg cagtgtcaag gaggatcgac tttgttacgg aggaccctgg 4860
aaattgcagc acaagtggaa cgggcaggat gaggtgcaga tgattgtggt ggaacctggc 4920
aagaacgtta agaacgtcca gacgaaacca ggggtgttca aaacacctga aggagaaatc 4980
ggggccgtga ctttggactt ccccactgga acatcaggct caccaatagt ggacaaaaac 5040
ggtgatgtga ttgggcttta tggcaatgga gtcataatgc ccaacggctc atacataagc 5100
gcgatagtgc agggtgaaag gatggatgag ccaatcccag ccggattcga acctgagatg 5160
ctgaggaaaa aacagatcac tgtactggat ctccatcccg gcgccggtaa aacaaggagg 5220
attctgccac agatcatcaa agaggccata aacagaagac tgagaacagc cgtgctagca 5280
ccaaccaggg ttgtggctgc tgagatggct gaagcactga gaggactgcc catccggtac 5340
cagacatccg cagtgcccag agaacataat ggaaatgaga ttgttgatgt catgtgtcat 5400
gctaccctca cccacaggct gatgtctcct cacagggtgc cgaactacaa cctgttcgtg 5460
atggatgagg ctcatttcac cgacccagct agtatcgcag caagaggtta catttccaca 5520
aaggtcgagc taggggaggc ggcggcaata ttcatgacag ccaccccacc aggcacttca 5580
gatccattcc cagagtccaa ttcaccaatt tccgacttac agactgagat cccggatcga 5640
gcttggaact ctggatacga atggatcaca gaatacaccg ggaagacggt ttggtttgtg 5700
cctagtgtca agatggggaa tgagattgcc ctttgcctac aacgtgctgg aaagaaagta 5760
gtccaattga acagaaagtc gtacgagacg gagtacccaa aatgtaagaa cgatgattgg 5820
gactttgtta tcacaacaga catatctgaa atgggggcta acttcaaggc gagcagggtg 5880
attgacagcc ggaagagtgt gaaaccaacc atcataacag aaggagaagg gagagtgatc 5940
ctgggagaac catctgcagt gacagcagct agtgccgccc agagacgtgg acgtatcggt 6000
agaaatccgt cgcaagttgg tgatgagtac tgttatgggg ggcacacgaa tgaagacgac 6060
tcgaacttcg cccattggac tgaggcacga atcatgctgg acaacatcaa catgccaaac 6120
ggactgatcg ctcaattcta ccaaccagag cgtgagaagg tatataccat ggatggggaa 6180
taccggctca gaggagaaga gaggaaaaac tttctggaac tgttgaggac tgcagatctg 6240
ccagtttggc tggcttacaa ggttgcagcg gctggagtgt cataccacga ccggaggtgg 6300
tgctttgatg gtcctaggac aaacacaatt ttagaagaca acaacgaagt ggaagtcatc 6360
acgaagcttg gtgaaaggaa gattctgagg ccgcgctgga ttgacgccag ggtgtactcg 6420
gatcaccagg cactaaaggc gttcaaggac ttcgcctcgg gaaaacgttc tcagataggg 6480
ctcattgagg ttctgggaaa gatgcctgag cacttcatgg ggaagacatg ggaagcactt 6540
gacaccatgt acgtagtggc cactgcagag aaaggaggaa gagctcacag aatggccctg 6600
gaggaactgc cagatgctct tcagacaatt gccttgattg ccttattgag tgtgatgacc 6660
atgggagtat tcttcctcct catgcagcgg aagggcattg gaaagatagg tttgggaggc 6720
gctgtcttgg gagtcgcgac ctttttctgt tggatggctg aagttccagg aacgaagatc 6780
gccggaatgt tgctgctctc ccttctcttg atgattgtgc taattcctga gccagagaag 6840
caacgttcgc agacagacaa ccagctagcc gtgttcctga tttgtgtcat gacccttgtg 6900
agcgcagtgg cagccaacga gatgggttgg ctagataaga ccaagagtga cataagcagt 6960
ttgtttgggc aaagaattga ggtcaaggag aatttcagca tgggagagtt tcttctggac 7020
ttgaggccgg caacagcctg gtcactgtac gctgtgacaa cagcggtcct cactccactg 7080
ctaaagcatt tgatcacgtc agattacatc aacacctcat tgacctcaat aaacgttcag 7140
gcaagtgcac tattcacact cgcgcgaggc ttccccttcg tcgatgttgg agtgtcggct 7200
ctcctgctag cagccggatg ctggggacaa gtcaccctca ccgttacggt aacagcggca 7260
acactccttt tttgccacta tgcctacatg gttcccggtt ggcaagctga ggcaatgcgc 7320
tcagcccagc ggcggacagc ggccggaatc atgaagaacg ctgtagtgga tggcatcgtg 7380
gccacggacg tcccagaatt agagcgcacc acacccatca tgcagaagaa agttggacag 7440
atcatgctga tcttggtgtc tctagctgca gtagtagtga acccgtctgt gaagacagta 7500
cgagaagccg gaattttgat cacggccgca gcggtgacgc tttgggagaa tggagcaagc 7560
tctgtttgga acgcaacaac tgccatcgga ctctgccaca tcatgcgtgg gggttggttg 7620
tcatgtctat ccataacatg gacactcata aagaacatgg aaaaaccagg actaaaaaga 7680
ggtggggcaa aaggacgcac cttgggagag gtttggaaag aaagactcaa ccagatgaca 7740
aaagaagagt tcactaggta ccgcaaagag gccatcatcg aagtcgatcg ctcagcggca 7800
aaacacgcca ggaaagaagg caatgtcact ggagggcatt cagtctctag gggcacagca 7860
aaactgagat ggctggtcga acggaggttt ctcgaaccgg tcggaaaagt gattgacctt 7920
ggatgtggaa gaggcggttg gtgttactat atggcaaccc aaaaaagagt ccaagaagtc 7980
agagggtaca caaagggcgg tcccggacat gaagagcccc aactagtgca aagttatgga 8040
tggaacattg tcaccatgaa gagtggagtg gatgtgttct acagaccttc tgagtgttgt 8100
gacaccctcc tttgtgacat cggagagtcc tcgtcaagtg ctgaggttga agagcatagg 8160
acgattcgtg tccttgaaat ggttgaggac tggctgcacc gagggccaag ggaattttgc 8220
gtgaaggtgc tctgccccta catgccgaaa gtcatagaga agatggagct gctccaacgc 8280
cggtatgggg ggggactggt cagaaaccca ctctcacgga attccacgca cgagatgtat 8340
tgggtgagtc gagcttcagg caatgtggta cattcagtga atatgaccag ccaggtgctc 8400
ctaggaagaa tggaaaaaag gacctggaag ggaccccaat acgaggaaga tgtaaacttg 8460
ggaagtggaa ccagggcggt gggaaaaccc ctgctcaact cagacaccag taaaatcaag 8520
aacaggattg aacgactcag gcgtgagtac agttcgacgt ggcaccacga tgagaaccac 8580
ccatatagaa cctggaacta tcacggcagt tatgatgtga agcccacagg ctccgccagt 8640
tcgctggtca atggagtggt caggctcctc tcaaaaccat gggacaccat cacgaatgtt 8700
accaccatgg ccatgactga cactactccc ttcgggcagc agcgagtgtt caaagagaag 8760
gtggacacga aagctcctga accgccagaa ggagcgaagt acgtgctcaa cgagaccacc 8820
aactggttgt gggcgttttt ggccagagaa aaacgtccca gaatgtgctc tcgagaggaa 8880
ttcataagaa aggtcaacag caatgcagct ttgggtgcca tgtttgaaga gcagaatcaa 8940
tggaggagcg ccagagaagc agttgaagat ccaaaatttt gggagatggt ggatgaggag 9000
cgcgaggcac atctgcgggg ggaatgtcac acttgcattt acaacatgat gggaaagaga 9060
gagaaaaaac ccggagagtt cggaaaggcc aagggaagca gagccatttg gttcatgtgg 9120
ctcggagctc gctttctgga gttcgaggct ctgggttttc tcaatgaaga ccactggctt 9180
ggaagaaaga actcaggagg aggtgtcgag ggcttgggcc tccaaaaact gggttacatc 9240
ctgcgtgaag ttggcacccg gcctgggggc aagatctatg ctgatgacac agctggctgg 9300
gacacccgca tcacgagagc tgacttggaa aatgaagcta aggtgcttga gctgcttgat 9360
ggggaacatc ggcgtcttgc cagggccatc attgagctca cctatcgtca caaagttgtg 9420
aaagtgatgc gcccggctgc tgatggaaga accgtcatgg atgttatctc cagagaagat 9480
cagaggggga gtggacaagt tgtcacctac gccctaaaca ctttcaccaa cctggccgtc 9540
cagctggtga ggatgatgga aggggaagga gtgattggcc cagatgatgt ggagaaactc 9600
acaaaaggga aaggacccaa agtcaggacc tggctgtttg agaatgggga agaaagactc 9660
agccgcatgg ctgtcagtgg agatgactgt gtggtaaagc ccctggacga tcgctttgcc 9720
acctcgctcc acttcctcaa tgctatgtca aaggttcgca aagacatcca agagtggaaa 9780
ccgtcaactg gatggtatga ttggcagcag gttccatttt gctcaaacca tttcactgaa 9840
ttgatcatga aagatggaag aacactggtg gttccatgcc gaggacagga tgaattggta 9900
ggcagagctc gcatatctcc aggggccgga tggaacgtcc gcgacactgc ttgtctggct 9960
aagtcttatg cccagatgtg gctgcttctg tacttccaca gaagagacct gcggctcatg 10020
gccaacgcca tttgctccgc tgtccctgtg aattgggtcc ctaccggaag aaccacgtgg 10080
tccatccatg caggaggaga gtggatgaca acagaggaca tgttggaggt ctggaaccgt 10140
gtttggatag aggagaatga atggatggaa gacaaaaccc cagtggagaa atggagtgac 10200
gtcccatatt caggaaaacg agaggacatc tggtgtggca gcctgattgg cacaagagcc 10260
cgagccacgt gggcagaaaa catccaggtg gctatcaacc aagtcagagc aatcatcgga 10320
gatgagaagt atgtggatta catgagttca ctaaagagat atgaagacac aactttggtt 10380
gaggacacag tactgtagat attaagaaaa ttttgaggag aaagtcaggc cgggaagttc 10440
ccgccaccgg aagttgagta gacggtgctg cctgcgactc aaccccagga ggactgggtg 10500
aacaaagccg cgaagtgatc catgtaagcc ctcagaaccg tctcggaagg aggaccccac 10560
atgttgtaac ttcaaagccc aatgtcagac cacgctacgg cgtgctactc tgcggagagt 10620
gcagtctgcg atagtgcccc aggaggactg ggttaacaaa ggcaaatcaa cgccccacgc 10680
ggccctagcc ccggtaatgg tgttaaccag ggcgaaagga ctagaggtta gaggagaccc 10740
cgcggtttaa agtgcacggc ccagcctggc tgaagctgta ggtcagggga aggactagag 10800
gttagtggag accccgtgcc acaaaacacc acaacaaaac agcatattga cacctgggat 10860
agactaggag atcttctgct ctgcacaacc agccacacgg cacagtgcgc cgacaatggt 10920
ggctggtggt gcgagaacac aggatct 10947
<210> 109
<211> 2219
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 109
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttgtagat atttaatcaa ttgtaaatag acaatataag 1620
tatgcataaa agtgtagttt tatagtagta tttagtggtg ttagtgtaaa tagttaagaa 1680
aattttgagg agaaagtcag gccgggaagt tcccgccacc ggaagttgag tagacggtgc 1740
tgcctgcgac tcaaccccag gaggactggg tgaacaaagc cgcgaagtga tccatgtaag 1800
ccctcagaac cgtctcggaa ggaggacccc acatgttgta acttcaaagc ccaatgtcag 1860
accacgctac ggcgtgctac tctgcggaga gtgcagtctg cgatagtgcc ccaggaggac 1920
tgggttaaca aaggcaaatc aacgccccac gcggccctag ccccggtaat ggtgttaacc 1980
agggcgaaag gactagaggt tagaggagac cccgcggttt aaagtgcacg gcccagcctg 2040
gctgaagctg taggtcaggg gaaggactag aggttagtgg agaccccgtg ccacaaaaca 2100
ccacaacaaa acagcatatt gacacctggg atagactagg agatcttctg ctctgcacaa 2160
ccagccacac ggcacagtgc gccgacaatg gtggctggtg gtgcgagaac acaggatct 2219
<210> 110
<211> 2932
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 110
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta 60
acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc 120
ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt 180
ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg 240
gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga 300
tggagaggtg tgaataaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta 360
gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag 420
accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac 480
ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt 540
ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc 600
gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc 660
gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc 720
cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg 780
aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa 840
tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt 900
gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct 960
tacagcttta actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca 1020
acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag 1080
cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt 1140
tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga 1200
gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac 1260
aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa 1320
tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa 1380
gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag 1440
gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta 1500
aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc 1560
aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc 1620
atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg 1680
ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa 1740
gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact 1800
gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag 1860
ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca 1920
ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt 1980
cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc 2040
aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc 2100
tttggagact catacatagt ggtgggcaga ggagaacaac agattaatca ccattggcac 2160
aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta 2220
gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt 2280
gggaaggctg tccatcaata gatatttaat caattgtaaa tagacaatat aagtatgcat 2340
aaaagtgtag ttttatagta gtatttagtg gtgttagtgt aaatagttaa gaaaattttg 2400
aggagaaagt caggccggga agttcccgcc accggaagtt gagtagacgg tgctgcctgc 2460
gactcaaccc caggaggact gggtgaacaa agccgcgaag tgatccatgt aagccctcag 2520
aaccgtctcg gaaggaggac cccacatgtt gtaacttcaa agcccaatgt cagaccacgc 2580
tacggcgtgc tactctgcgg agagtgcagt ctgcgatagt gccccaggag gactgggtta 2640
acaaaggcaa atcaacgccc cacgcggccc tagccccggt aatggtgtta accagggcga 2700
aaggactaga ggttagagga gaccccgcgg tttaaagtgc acggcccagc ctggctgaag 2760
ctgtaggtca ggggaaggac tagaggttag tggagacccc gtgccacaaa acaccacaac 2820
aaaacagcat attgacacct gggatagact aggagatctt ctgctctgca caaccagcca 2880
cacggcacag tgcgccgaca atggtggctg gtggtgcgag aacacaggat ct 2932
<210> 111
<211> 14195
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 111
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60
gttctctaaa agaactttaa gtcagttctt tattatcaaa acaatgtttt tatgtctgaa 120
gcaaaatgtt ggactgagac tgaccttact aaaggacctc atgaattttg ctctcaacat 180
acaatgctag ttaaacaggg tgatgattat gtgtaccttc cttacccaga tccatcaaga 240
atcctagggg ccggctgttt tgtagatgat atcgtaaaaa cagatggtac acttatgatt 300
gaacggttcg tgtctttagc tatagatgct tacccactta ctaaacatcc taatcaggag 360
tatgctgatg tctttcattt gtacttacaa tacataagaa agctacatga tgagttaaca 420
ggacacatgt tagacatgta ttctgttatg cttactaatg ataacacttc aaggtattgg 480
gaacctgagt tttatgaggc tatgtacaca ccgcatacag tcttacaggc tgttggggct 540
tgtgttcttt gcaattcaca gacttcatta agatgtggtg cttgcatacg tagaccattc 600
ttatgttgta aatgctgtta cgaccatgtc atatcaacat cacataaatt agtcttgtct 660
gttaatccgt atgtttgcaa tgctccaggt tgtgatgtca cagatgtgac tcaactttac 720
ttaggaggta tgagctatta ttgtaaatca cataaaccac ccattagttt tccattgtgt 780
gctaatggac aagtttttgg tttatataaa aatacatgtg ttggtagcga taatgttact 840
gactttaatg caattgcaac atgtgactgg acaaatgctg gtgattacat tttagctaac 900
acctgtactg aaagactcaa gctttttgca gcagaaacgc tcaaagctac tgaggagaca 960
tttaaactgt cttatggtat tgctactgta cgtgaagtgc tgtctgacag agaattacat 1020
ctttcatggg aagttggtaa acctagacca ccacttaacc gaaattatgt ctttactggt 1080
tatcgtgtaa ctaaaaacag taaagtacaa ataggagagt acacctttga aaaaggtgac 1140
tatggtgatg ctgttgttta ccgaggtaca acaacttaca aattaaatgt tggtgattat 1200
tttgtgctga catcacatac agtaatgcca ttaagtgcac ctacactagt gccacaagag 1260
cactatgtta gaattactgg cttataccca acactcaata tctcagatga gttttctagc 1320
aatgttgcaa attatcaaaa ggttggtatg caaaagtatt ctacactcca gggaccacct 1380
ggtactggta agagtcattt tgctattggc ctagctctct actacccttc tgctcgcata 1440
gtgtatacag cttgctctca tgccgctgtt gatgcactat gtgagaaggc attaaaatat 1500
ttgcctatag ataaatgtag tagaattata cctgcacgtg ctcgtgtaga gtgttttgat 1560
aaattcaaag tgaattcaac attagaacag tatgtctttt gtactgtaaa tgcattgcct 1620
gagacgacag cagatatagt tgtctttgat gaaatttcaa tggccacaaa ttatgatttg 1680
agtgttgtca atgccagatt acgtgctaag cactatgtgt acattggcga ccctgctcaa 1740
ttacctgcac cacgcacatt gctaactaag ggcacactag aaccagaata tttcaattca 1800
gtgtgtagac ttatgaaaac tataggtcca gacatgttcc tcggaacttg tcggcgttgt 1860
cctgctgaaa ttgttgacac tgtgagtgct ttggtttatg ataataagct taaagcacat 1920
aaagacaaat cagctcaatg ctttaaaatg ttttataagg gtgttatcac gcatgatgtt 1980
tcatctgcaa ttaacaggcc acaaataggc gtggtaagag aattccttac acgtaaccct 2040
gcttggagaa aagctgtctt tatttcacct tataattcac agaatgctgt agcctcaaag 2100
attttgggac taccaactca aactgttgat tcatcacagg gctcagaata tgactatgtc 2160
atattcactc aaaccactga aacagctcac tcttgtaatg taaacagatt taatgttgct 2220
attaccagag caaaagtagg catactttgc ataatgtctg atagagacct ttatgacaag 2280
ttgcaattta caagtcttga aattccacgt aggaatgtgg caactttaca agctgaaaat 2340
gtaacaggac tctttaaaga ttgtagtaag gtaatcactg ggttacatcc tacacaggca 2400
cctacacacc tcagtgttga cactaaattc aaaactgaag gtttatgtgt tgacatacct 2460
ggcataccta aggacatgac ctatagaaga ctcatctcta tgatgggttt taaaatgaat 2520
tatcaagtta atggttaccc taacatgttt atcacccgcg aagaagctat aagacatgta 2580
cgtgcatgga ttggcttcga tgtcgagggg tgtcatgcta ctagagaagc tgttggtacc 2640
aatttacctt tacagctagg tttttctaca ggtgttaacc tagttgctgt acctacaggt 2700
tatgttgata cacctaataa tacagatttt tccagagtta gtgctaaacc accgcctgga 2760
gatcaattta aacacctcat accacttatg tacaaaggac ttccttggaa tgtagtgcgt 2820
ataaagattg tacaaatgtt aagtgacaca cttaaaaatc tctctgacag agtcgtattt 2880
gtcttatggg cacatggctt tgagttgaca tctatgaagt attttgtgaa aataggacct 2940
gagcgcacct gttgtctatg tgatagacgt gccacatgct tttccactgc ttcagacact 3000
tatgcctgtt ggcatcattc tattggattt gattacgtct ataatccgtt tatgattgat 3060
gttcaacaat ggggttttac aggtaaccta caaagcaacc atgatctgta ttgtcaagtc 3120
catggtaatg cacatgtagc tagttgtgat gcaatcatga ctaggtgtct agctgtccac 3180
gagtgctttg ttaagcgtgt tgactggact attgaatatc ctataattgg tgatgaactg 3240
aagattaatg cggcttgtag aaaggttcaa cacatggttg ttaaagctgc attattagca 3300
gacaaattcc cagttcttca cgacattggt aaccctaaag ctattaagtg tgtacctcaa 3360
gctgatgtag aatggaagtt ctatgatgca cagccttgta gtgacaaagc ttataaaata 3420
gaagaattat tctattctta tgccacacat tctgacaaat tcacagatgg tgtatgccta 3480
ttttggaatt gcaatgtcga tagatatcct gctaattcca ttgtttgtag atttgacact 3540
agagtgctat ctaaccttaa cttgcctggt tgtgatggtg gcagtttgta tgtaaataaa 3600
catgcattcc acacaccagc ttttgataaa agtgcttttg ttaatttaaa acaattacca 3660
tttttctatt actctgacag tccatgtgag tctcatggaa aacaagtagt gtcagatata 3720
gattatgtac cactaaagtc tgctacgtgt ataacacgtt gcaatttagg tggtgctgtc 3780
tgtagacatc atgctaatga gtacagattg tatctcgatg cttataacat gatgatctca 3840
gctggcttta gcttgtgggt ttacaaacaa tttgatactt ataacctctg gaacactttt 3900
acaagacttc agagtttaga aaatgtggct tttaatgttg taaataaggg acactttgat 3960
ggacaacagg gtgaagtacc agtttctatc attaataaca ctgtttacac aaaagttgat 4020
ggtgttgatg tagaattgtt tgaaaataaa acaacattac ctgttaatgt agcatttgag 4080
ctttgggcta agcgcaacat taaaccagta ccagaggtga aaatactcaa taatttgggt 4140
gtggacattg ctgctaatac tgtgatctgg gactacaaaa gagatgctcc agcacatata 4200
tctactattg gtgtttgttc tatgactgac atagccaaga aaccaactga aacgatttgt 4260
gcaccactca ctgtcttttt tgatggtaga gttgatggtc aagtagactt atttagaaat 4320
gcccgtaatg gtgttcttat tacagaaggt agtgttaaag gtttacaacc atctgtaggt 4380
cccaaacaag ctagtcttaa tggagtcaca ttaattggag aagccgtaaa aacacagttc 4440
aattattata agaaagttga tggtgttgtc caacaattac ctgaaactta ctttactcag 4500
agtagaaatt tacaagaatt taaacccagg agtcaaatgg aaattgattt cttagaatta 4560
gctatggatg aattcattga acggtataaa ttagaaggct atgccttcga acatatcgtt 4620
tatggagatt ttagtcatag tcagttaggt ggtttacatc tactgattgg actagctaaa 4680
cgttttaagg aatcaccttt tgaattagaa gattttattc ctatggacag tacagttaaa 4740
aactatttca taacagatgc gcaaacaggt tcatctaagt gtgtgtgttc tgttattgat 4800
ttattacttg atgattttgt tgaaataata aaatcccaag atttatctgt agtttctaag 4860
gttgtcaaag tgactattga ctatacagaa atttcattta tgctttggtg taaagatggc 4920
catgtagaaa cattttaccc aaaattacaa tctagtcaag cgtggcaacc gggtgttgct 4980
atgcctaatc tttacaaaat gcaaagaatg ctattagaaa agtgtgacct tcaaaattat 5040
ggtgatagtg caacattacc taaaggcata atgatgaatg tcgcaaaata tactcaactg 5100
tgtcaatatt taaacacatt aacattagct gtaccctata atatgagagt tatacatttt 5160
ggtgctggtt ctgataaagg agttgcacca ggtacagctg ttttaagaca gtggttgcct 5220
acgggtacgc tgcttgtcga ttcagatctt aatgactttg tctctgatgc agattcaact 5280
ttgattggtg attgtgcaac tgtacataca gctaataaat gggatctcat tattagtgat 5340
atgtacgacc ctaagactaa aaatgttaca aaagaaaatg actctaaaga gggttttttc 5400
acttacattt gtgggtttat acaacaaaag ctagctcttg gaggttccgt ggctataaag 5460
ataacagaac attcttggaa tgctgatctt tataagctca tgggacactt cgcatggtgg 5520
acagcctttg ttactaatgt gaatgcgtca tcatctgaag catttttaat tggatgtaat 5580
tatcttggca aaccacgcga acaaatagat ggttatgtca tgcatgcaaa ttacatattt 5640
tggaggaata caaatccaat tcagttgtct tcctattctt tatttgacat gagtaaattt 5700
ccccttaaat taaggggtac tgctgttatg tctttaaaag aaggtcaaat caatgatatg 5760
attttatctc ttcttagtaa aggtagactt ataattagag aaaacaacag agttgttatt 5820
tctagtgatg ttcttgttaa caactaaacg aacaatgttt gtttttcttg ttttattgcc 5880
actagtctct agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac 5940
taattctttc acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca 6000
ttcaactcag gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca 6060
tgtctctggg accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg 6120
tgtttatttt gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac 6180
tttagattcg aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa 6240
agtctgtgaa tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa 6300
caaaagttgg atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga 6360
atatgtctct cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct 6420
tagggaattt gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc 6480
tattaattta gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt 6540
gccaataggt attaacatca ctaggtttca aactttactt gctttacata gaagttattt 6600
gactcctggt gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta 6660
tcttcaacct aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt 6720
agactgtgca cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga 6780
aaaaggaatc tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt 6840
tcctaatatt acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc 6900
tgtttatgct tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata 6960
taattccgca tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga 7020
tctctgcttt actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca 7080
aatcgctcca gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt 7140
tacaggctgc gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta 7200
taattacctg tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc 7260
aactgaaatc tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta 7320
ctttccttta caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag 7380
agtagtagta ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa 7440
gtctactaat ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac 7500
aggtgttctt actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat 7560
tgctgacact actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc 7620
atgttctttt ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc 7680
tgttctttat caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact 7740
tactcctact tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg 7800
tttaataggg gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg 7860
tatatgcgct agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag 7920
tcaatccatc attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa 7980
taactctatt gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt 8040
gtctatgacc aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg 8100
cagcaatctt ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg 8160
aatagctgtt gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta 8220
caaaacacca ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc 8280
atcaaaacca agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc 8340
agatgctggc ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct 8400
catttgtgca caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat 8460
gattgctcaa tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg 8520
tgcaggtgct gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat 8580
tggagttaca cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag 8640
tgctattggc aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca 8700
agatgtggtc aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa 8760
ttttggtgca atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc 8820
tgaagtgcaa attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac 8880
tcaacaatta attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat 8940
gtcagagtgt gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct 9000
tatgtccttc cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc 9060
tgcacaagaa aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt 9120
tcctcgtgaa ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt 9180
ttatgaacca caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt 9240
aataggaatt gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa 9300
ggaggagtta gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat 9360
ctctggcatt aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt 9420
tgccaagaat ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta 9480
tataaaatgg ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat 9540
ggtgacaatt atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc 9600
ttgtggatcc tgctgcaaat ttgatgaaga cgactctgag ccagtgctca aaggagtcaa 9660
attacattac acataaacga acttatggat ttgtttatga gaatcttcac aattggaact 9720
gtaactttga agcaaggtga aatcaaggat gctactcctt cagattttgt tcgcgctact 9780
gcaacgatac cgatacaagc ctcactccct ttcggatggc ttattgttgg cgttgcactt 9840
cttgctgttt ttcagagcgc ttccaaaatc ataaccctca aaaagagatg gcaactagca 9900
ctctccaagg gtgttcactt tgtttgcaac ttgctgttgt tgtttgtaac agtttactca 9960
caccttttgc tcgttgctgc tggccttgaa gccccttttc tctatcttta tgctttagtc 10020
tacttcttgc agagtataaa ctttgtaaga ataataatga ggctttggct ttgctggaaa 10080
tgccgttcca aaaacccatt actttatgat gccaactatt ttctttgctg gcatactaat 10140
tgttacgact attgtatacc ttacaatagt gtaacttctt caattgtcat tacttcaggt 10200
gatggcacaa caagtcctat ttctgaacat gactaccaga ttggtggtta tactgaaaaa 10260
tgggaatctg gagtaaaaga ctgtgttgta ttacacagtt acttcacttc agactattac 10320
cagctgtact caactcaatt gagtacagac actggtgttg aacatgttac cttcttcatc 10380
tacaataaaa ttgttgatga gcctgaagaa catgtccaaa ttcacacaat cgacggttca 10440
tccggagttg ttaatccagt aatggaacca atttatgatg aaccgacgac gactactagc 10500
gtgcctttgt aagcacaagc tgatgagtac gaacttatgt actcattcgt ttcggaagag 10560
acaggtacgt taatagttaa tagcgtactt ctttttcttg ctttcgtggt attcttgcta 10620
gttacactag ccatccttac tgcgcttcga ttgtgtgcgt actgctgcaa tattgttaac 10680
gtgagtcttg taaaaccttc tttttacgtt tactctcgtg ttaaaaatct gaattcttct 10740
agagttcctg atcttctggt ctaaacgaac taaatattat attagttttt ctgtttggaa 10800
ctttaatttt agccatggca gattccaacg gtactattac cgttgaagag cttaaaaagc 10860
tccttgaaca atggaaccta gtaataggtt tcctattcct tacatggatt tgtcttctac 10920
aatttgccta tgccaacagg aataggtttt tgtatataat taagttaatt ttcctctggc 10980
tgttatggcc agtaacttta gcttgttttg tgcttgctgc tgtttacaga ataaattgga 11040
tcaccggtgg aattgctatc gcaatggctt gtcttgtagg cttgatgtgg ctcagctact 11100
tcattgcttc tttcagactg tttgcgcgta cgcgttccat gtggtcattc aatccagaaa 11160
ctaacattct tctcaacgtg ccactccatg gcactattct gaccagaccg cttctagaaa 11220
gtgaactcgt aatcggagct gtgatccttc gtggacatct tcgtattgct ggacaccatc 11280
taggacgctg tgacatcaag gacctgccta aagaaatcac tgttgctaca tcacgaacgc 11340
tttcttatta caaattggga gcttcgcagc gtgtagcagg tgactcaggt tttgctgcat 11400
acagtcgcta caggattggc aactataaat taaacacaga ccattccagt agcagtgaca 11460
atattgcttt gcttgtacag taagtgacaa cagatgtttc atctcgttga ctttcaggtt 11520
actatagcag agatattact aattattatg aggactttta aagtttccat ttggaatctt 11580
gattacatca taaacctcat aattaaaaat ttatctaagt cactaactga gaataaatat 11640
tctcaattag atgaagagca accaatggag attgattaaa cgaacatgaa aattattctt 11700
ttcttggcac tgataacact cgctacttgt gagctttatc actaccaaga gtgtgttaga 11760
ggtacaacag tacttttaaa agaaccttgc tcttctggaa catacgaggg caattcacca 11820
tttcatcctc tagctgataa caaatttgca ctgacttgct ttagcactca atttgctttt 11880
gcttgtcctg acggcgtaaa acacgtctat cagttacgtg ccagatcagt ttcacctaaa 11940
ctgttcatca gacaagagga agttcaagaa ctttactctc caatttttct tattgttgcg 12000
gcaatagtgt ttataacact ttgcttcaca ctcaaaagaa agacagaatg attgaacttt 12060
cattaattga cttctatttg tgctttttag cctttctgct attccttgtt ttaattatgc 12120
ttattatctt ttggttctca cttgaactgc aagatcataa tgaaacttgt cacgcctaaa 12180
cgaacatgaa atttcttgtt ttcttaggaa tcatcacaac tgtagctgca tttcaccaag 12240
aatgtagttt acagtcatgt actcaacatc aaccatatgt agttgatgac ccgtgtccta 12300
ttcacttcta ttctaaatgg tatattagag taggagctag aaaatcagca cctttaattg 12360
aattgtgcgt ggatgaggct ggttctaaat cacccattca gtacatcgat atcggtaatt 12420
atacagtttc ctgtttacct tttacaatta attgccagga acctaaattg ggtagtcttg 12480
tagtgcgttg ttcgttctat gaagactttt tagagtatca tgacgttcgt gttgttttag 12540
atttcatcta aacgaacaaa ctaaaatgtc tgataatgga ccccaaaatc agcgaaatgc 12600
accccgcatt acgtttggtg gaccctcaga ttcaactggc agtaaccaga atggagaacg 12660
cagtggggcg cgatcaaaac aacgtcggcc ccaaggttta cccaataata ctgcgtcttg 12720
gttcaccgct ctcactcaac atggcaagga agaccttaaa ttccctcgag gacaaggcgt 12780
tccaattaac accaatagca gtccagatga ccaaattggc tactaccgaa gagctaccag 12840
acgaattcgt ggtggtgacg gtaaaatgaa agatctcagt ccaagatggt atttctacta 12900
cctaggaact gggccagaag ctggacttcc ctatggtgct aacaaagacg gcatcatatg 12960
ggttgcaact gagggagcct tgaatacacc aaaagatcac attggcaccc gcaatcctgc 13020
taacaatgct gcaatcgtgc tacaacttcc tcaaggaaca acattgccaa aaggcttcta 13080
cgcagaaggg agcagaggcg gcagtcaagc ctcttctcgt tcctcatcac gtagtcgcaa 13140
cagttcaaga aattcaactc caggcagcag taggggaact tctcctgcta gaatggctgg 13200
caatggcggt gatgctgctc ttgctttgct gctgcttgac agattgaacc agcttgagag 13260
caaaatgtct ggtaaaggcc aacaacaaca aggccaaact gtcactaaga aatctgctgc 13320
tgaggcttct aagaagcctc ggcaaaaacg tactgccact aaagcataca atgtaacaca 13380
agctttcggc agacgtggtc cagaacaaac ccaaggaaat tttggggacc aggaactaat 13440
cagacaagga actgattaca aacattggcc gcaaattgca caatttgccc ccagcgcttc 13500
agcgttcttc ggaatgtcgc gcattggcat ggaagtcaca ccttcgggaa cgtggttgac 13560
ctacacaggt gccatcaaat tggatgacaa agatccaaat ttcaaagatc aagtcatttt 13620
gctgaataag catattgacg catacaaaac attcccacca acagagccta aaaaggacaa 13680
aaagaagaag gctgatgaaa ctcaagcctt accgcagaga cagaagaaac agcaaactgt 13740
gactcttctt cctgctgcag atttggatga tttctccaaa caattgcaac aatccatgag 13800
cagtgctgac tcaactcagg cctaaactca tgcagaccac acaaggcaga tgggctatat 13860
aaacgttttc gcttttccgt ttacgatata tagtctactc ttgtgcagaa tgaattctcg 13920
taactacata gcacaagtag atgtagttaa ctttaatctc acatagcaat ctttaatcag 13980
tgtgtaacat tagggaggac ttgaaagagc caccacattt tcaccgaggc cacgcggagt 14040
acgatcgagt gtacagtgaa caatgctagg gagagctgcc tatatggaag agccctaatg 14100
tgtaaaatta attttagtag tgctatcccc atgtgatttt aatagcttct taggagaatg 14160
acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 14195
<210> 112
<211> 1999
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 112
tcttaatgga gtcacattaa ttggagaagc cgtaaaaaca cagttcaatt attataagaa 60
agttgatggt gttgtccaac aattacctga aacttacttt actcagagta gaaatttaca 120
agaatttaaa cccaggagtc aaatggaaat tgatttctta gaattagcta tggatgaatt 180
cattgaacgg tataaattag aaggctatgc cttcgaacat atcgtttatg gagattttag 240
tcatagtcag ttaggtggtt tacatctact gattggacta gctaaacgtt ttaaggaatc 300
accttttgaa ttagaagatt ttattcctat ggacagtaca gttaaaaact atttcataac 360
agatgcgcaa acaggttcat ctaagtgtgt gtgttctgtt attgatttat tacttgatga 420
ttttgttgaa ataataaaat cccaagattt atctgtagtt tctaaggttg tcaaagtgac 480
tattgactat acagaaattt catttatgct ttggtgtaaa gatggccatg tagaaacatt 540
ttacccaaaa ttacaatcta gtcaagcgtg gcaaccgggt gttgctatgc ctaatcttta 600
caaaatgcaa agaatgctat tagaaaagtg tgaccttcaa aattatggtg atagtgcaac 660
attacctaaa ggcataatga tgaatgtcgc aaaatatact caactgtgtc aatatttaaa 720
cacattaaca ttagctgtac cctataatat gagagttata cattttggtg ctggttctga 780
taaaggagtt gcaccaggta cagctgtttt aagacagtgg ttgcctacgg gtacgctgct 840
tgtcgattca gatcttaatg actttgtctc tgatgcagat tcaactttga ttggtgattg 900
tgcaactgta catacagcta ataaatggga tctcattatt agtgatatgt acgaccctaa 960
gactaaaaat gttacaaaag aaaatgactc taaagagggt tttttcactt acatttgtgg 1020
gtttatacaa caaaagctag ctcttggagg ttccgtggct ataaagataa cagaacattc 1080
ttggaatgct gatctttata agctcatggg acacttcgca tggtggacag cctttgttac 1140
taatgtgaat gcgtcatcat ctgaagcatt tttaattgga tgtaattatc ttggcaaacc 1200
acgcgaacaa atagatggtt atgtcatgca tgcaaattac atattttgga ggaatacaaa 1260
tccaattcag ttgtcttcct attctttatt tgacatgagt aaatttcccc ttaaattaag 1320
gggtactgct gttatgtctt taaaagaagg tcaaatcaat gatatgattt tatctcttct 1380
tagtaaaggt agacttataa ttagagaaaa caacagagtt gttatttcta gtgatgttct 1440
tgttaacaac taaacgaaca atgtttgttt ttcttgtttt attgccacta gtctctagtc 1500
agtgtgttaa tcttacaacc agaactcaat taccccctgc atacactaat tctttcacac 1560
gtggtgttta ttaccctgac aaagttttca gatcctcagt tttacattca actcaggact 1620
tgttcttacc tttcttttcc aatgttactt ggttccatgc tatacatgtc tctgggacca 1680
atggtactaa gaggtttgat aaccctgtcc taccatttaa tgatggtgtt tattttgctt 1740
ccactgagaa gtctaacata ataagaggct ggatttttgg tactacttta gattcgaaga 1800
cccagtccct acttattgtt aataacgcta ctaatgttgt tattaaagtc tgtgaatttc 1860
aattttgtaa tgatccattt ttgggtgttt attaccacaa aaacaacaaa agttggatgg 1920
aaagtgagtt cagagtttat tctagtgcga ataattgcac ttttgaatat gtctctcagc 1980
cttttcttat ggaccttga 1999
<210> 113
<211> 15602
<212> DNA
<213> 人工序列(Artificial Sequence)
<220>
<223> 合成序列(Synthetic sequence)
<400> 113
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct 60
gttctctaaa caaactttaa tgttttattc tctacagtgt tcccacctac aagttttgga 120
ccactagtga gaaaaatatt tgttgatggt gttccatttg tagtttcaac tggataccac 180
ttcagagagc taggtgttgt acataatcag gatgtaaact tacatagctc tagacttagt 240
tttaaggaat tacttgtgta tgctgctgac cctgctatgc acgctgcttc tggtaatcta 300
ttactagata aacgcactac gtgcttttca gtagctgcac ttactaacaa tgttgctttt 360
caaactgtca aacccggtaa ttttaacaaa gacttctatg actttgctgt gtctaagggt 420
ttctttaagg aaggaagttc tgttgaatta aaacacttct tctttgctca ggatggtaat 480
gctgctatca gcgattatga ctactatcgt tataatctac caacaatgtg tgatatcaga 540
caactactat ttgtagttga agttgttgat aagtactttg attgttacga tggtggctgt 600
attaatgcta accaagtcat cgtcaacaac ctagacaaat cagctggttt tccatttaat 660
aaatggggta aggctagact ttattatgat tcaatgagtt atgaggatca agatgcactt 720
ttcgcatata caaaacgtaa tgtcatccct actataactc aaatgaatct taagtatgcc 780
attagtgcaa agaatagagc tcgcaccgta gctggtgtct ctatctgtag tactatgacc 840
aatagacagt ttcatcaaaa attattgaaa tcaatagccg ccactagagg agctactgta 900
gtaattggaa caagcaaatt ctatggtggt tggcacaaca tgttaaaaac tgtttatagt 960
gatgtagaaa accctcacct tatgggttgg gattatccta aatgtgatag agccatgcct 1020
aacatgctta gaattatggc ctcacttgtt cttgctcgca aacatacaac gtgttgtagc 1080
ttgtcacacc gtttctatag attagctaat gagtgtgctc aagtattgag tgaaatggtc 1140
atgtgtggcg gttcactata tgttaaacca ggtggaacct catcaggaga tgccacaact 1200
gcttatgcta atagtgtttt taacatttgt caagctgtca cggccaatgt taatgcactt 1260
ttatctactg atggtaacaa aattgccgat aagtatgtcc gcaatttaca acacagactt 1320
tatgagtgtc tctatagaaa tagagatgtt gacacagact ttgtgaatga gttttacgca 1380
tatttgcgta aacatttctc aatgatgata ctctctgacg atgctgttgt gtgtttcaat 1440
agcacttatg catctcaagg tctagtggct agcataaaga actttaagtc agttctttat 1500
tatcaaaaca atgtttttat gtctgaagca aaatgttgga ctgagactga ccttactaaa 1560
ggacctcatg aattttgctc tcaacataca atgctagtta aacagggtga tgattatgtg 1620
taccttcctt acccagatcc atcaagaatc ctaggggccg gctgttttgt agatgatatc 1680
gtaaaaacag atggtacact tatgattgaa cggttcgtgt ctttagctat agatgcttac 1740
ccacttacta aacatcctaa tcaggagtat gctgatgtct ttcatttgta cttacaatac 1800
ataagaaagc tacatgatga gttaacagga cacatgttag acatgtattc tgttatgctt 1860
actaatgata acacttcaag gtattgggaa cctgagtttt atgaggctat gtacacaccg 1920
catacagtct tacaggctgt tggggcttgt gttctttgca attcacagac ttcattaaga 1980
tgtggtgctt gcatacgtag accattctta tgttgtaaat gctgttacga ccatgtcata 2040
tcaacatcac ataaattagt cttgtctgtt aatccgtatg tttgcaatgc tccaggttgt 2100
gatgtcacag atgtgactca actttactta ggaggtatga gctattattg taaatcacat 2160
aaaccaccca ttagttttcc attgtgtgct aatggacaag tttttggttt atataaaaat 2220
acatgtgttg gtagcgataa tgttactgac tttaatgcaa ttgcaacatg tgactggaca 2280
aatgctggtg attacatttt agctaacacc tgtactgaaa gactcaagct ttttgcagca 2340
gaaacgctca aagctactga ggagacattt aaactgtctt atggtattgc tactgtacgt 2400
gaagtgctgt ctgacagaga attacatctt tcatgggaag ttggtaaacc tagaccacca 2460
cttaaccgaa attatgtctt tactggttat cgtgtaacta aaaacagtaa agtacaaata 2520
ggagagtaca cctttgaaaa aggtgactat ggtgatgctg ttgtttaccg aggtacaaca 2580
acttacaaat taaatgttgg tgattatttt gtgctgacat cacatacagt aatgccatta 2640
agtgcaccta cactagtgcc acaagagcac tatgttagaa ttactggctt atacccaaca 2700
ctcaatatct cagatgagtt ttctagcaat gttgcaaatt atcaaaaggt tggtatgcaa 2760
aagtattcta cactccaggg accacctggt actggtaaga gtcattttgc tattggccta 2820
gctctctact acccttctgc tcgcatagtg tatacagctt gctctcatgc cgctgttgat 2880
gcactatgtg agaaggcatt aaaatatttg cctatagata aatgtagtag aattatacct 2940
gcacgtgctc gtgtagagtg ttttgataaa ttcaaagtga attcaacatt agaacagtat 3000
gtcttttgta ctgtaaatgc attgcctgag acgacagcag atatagttgt ctttgatgaa 3060
atttcaatgg ccacaaatta tgatttgagt gttgtcaatg ccagattacg tgctaagcac 3120
tatgtgtaca ttggcgaccc tgctcaatta cctgcaccac gcacattgct aactaagggc 3180
acactagaac cagaatattt caattcagtg tgtagactta tgaaaactat aggtccagac 3240
atgttcctcg gaacttgtcg gcgttgtcct gctgaaattg ttgacactgt gagtgctttg 3300
gtttatgata ataagcttaa agcacataaa gacaaatcag ctcaatgctt taaaatgttt 3360
tataagggtg ttatcacgca tgatgtttca tctgcaatta acaggccaca aataggcgtg 3420
gtaagagaat tccttacacg taaccctgct tggagaaaag ctgtctttat ttcaccttat 3480
aattcacaga atgctgtagc ctcaaagatt ttgggactac caactcaaac tgttgattca 3540
tcacagggct cagaatatga ctatgtcata ttcactcaaa ccactgaaac agctcactct 3600
tgtaatgtaa acagatttaa tgttgctatt accagagcaa aagtaggcat actttgcata 3660
atgtctgata gagaccttta tgacaagttg caatttacaa gtcttgaaat tccacgtagg 3720
aatgtggcaa ctttacaagc tgaaaatgta acaggactct ttaaagattg tagtaaggta 3780
atcactgggt tacatcctac acaggcacct acacacctca gtgttgacac taaattcaaa 3840
actgaaggtt tatgtgttga catacctggc atacctaagg acatgaccta tagaagactc 3900
atctctatga tgggttttaa aatgaattat caagttaatg gttaccctaa catgtttatc 3960
acccgcgaag aagctataag acatgtacgt gcatggattg gcttcgatgt cgaggggtgt 4020
catgctacta gagaagctgt tggtaccaat ttacctttac agctaggttt ttctacaggt 4080
gttaacctag ttgctgtacc tacaggttat gttgatacac ctaataatac agatttttcc 4140
agagttagtg ctaaaccacc gcctggagat caatttaaac acctcatacc acttatgtac 4200
aaaggacttc cttggaatgt agtgcgtata aagattgtac aaatgttaag tgacacactt 4260
aaaaatctct ctgacagagt cgtatttgtc ttatgggcac atggctttga gttgacatct 4320
atgaagtatt ttgtgaaaat aggacctgag cgcacctgtt gtctatgtga tagacgtgcc 4380
acatgctttt ccactgcttc agacacttat gcctgttggc atcattctat tggatttgat 4440
tacgtctata atccgtttat gattgatgtt caacaatggg gttttacagg taacctacaa 4500
agcaaccatg atctgtattg tcaagtccat ggtaatgcac atgtagctag ttgtgatgca 4560
atcatgacta ggtgtctagc tgtccacgag tgctttgtta agcgtgttga ctggactatt 4620
gaatatccta taattggtga tgaactgaag attaatgcgg cttgtagaaa ggttcaacac 4680
atggttgtta aagctgcatt attagcagac aaattcccag ttcttcacga cattggtaac 4740
cctaaagcta ttaagtgtgt acctcaagct gatgtagaat ggaagttcta tgatgcacag 4800
ccttgtagtg acaaagctta taaaatagaa gaattattct attcttatgc cacacattct 4860
gacaaattca cagatggtgt atgcctattt tggaattgca atgtcgatag atatcctgct 4920
aattccattg tttgtagatt tgacactaga gtgctatcta accttaactt gcctggttgt 4980
gatggtggca gtttgtatgt aaataaacat gcattccaca caccagcttt tgataaaagt 5040
gcttttgtta atttaaaaca attaccattt ttctattact ctgacagtcc atgtgagtct 5100
catggaaaac aagtagtgtc agatatagat tatgtaccac taaagtctgc tacgtgtata 5160
acacgttgca atttaggtgg tgctgtctgt agacatcatg ctaatgagta cagattgtat 5220
ctcgatgctt ataacatgat gatctcagct ggctttagct tgtgggttta caaacaattt 5280
gatacttata acctctggaa cacttttaca agacttcaga gtttagaaaa tgtggctttt 5340
aatgttgtaa ataagggaca ctttgatgga caacagggtg aagtaccagt ttctatcatt 5400
aataacactg tttacacaaa agttgatggt gttgatgtag aattgtttga aaataaaaca 5460
acattacctg ttaatgtagc atttgagctt tgggctaagc gcaacattaa accagtacca 5520
gaggtgaaaa tactcaataa tttgggtgtg gacattgctg ctaatactgt gatctgggac 5580
tacaaaagag atgctccagc acatatatct actattggtg tttgttctat gactgacata 5640
gccaagaaac caactgaaac gatttgtgca ccactcactg tcttttttga tggtagagtt 5700
gatggtcaag tagacttatt tagaaatgcc cgtaatggtg ttcttattac agaaggtagt 5760
gttaaaggtt tacaaccatc tgtaggtccc aaacaagcta gtcttaatgg agtcacatta 5820
attggagaag ccgtaaaaac acagttcaat tattataaga aagttgatgg tgttgtccaa 5880
caattacctg aaacttactt tactcagagt agaaatttac aagaatttaa acccaggagt 5940
caaatggaaa ttgatttctt agaattagct atggatgaat tcattgaacg gtataaatta 6000
gaaggctatg ccttcgaaca tatcgtttat ggagatttta gtcatagtca gttaggtggt 6060
ttacatctac tgattggact agctaaacgt tttaaggaat caccttttga attagaagat 6120
tttattccta tggacagtac agttaaaaac tatttcataa cagatgcgca aacaggttca 6180
tctaagtgtg tgtgttctgt tattgattta ttacttgatg attttgttga aataataaaa 6240
tcccaagatt tatctgtagt ttctaaggtt gtcaaagtga ctattgacta tacagaaatt 6300
tcatttatgc tttggtgtaa agatggccat gtagaaacat tttacccaaa attacaatct 6360
agtcaagcgt ggcaaccggg tgttgctatg cctaatcttt acaaaatgca aagaatgcta 6420
ttagaaaagt gtgaccttca aaattatggt gatagtgcaa cattacctaa aggcataatg 6480
atgaatgtcg caaaatatac tcaactgtgt caatatttaa acacattaac attagctgta 6540
ccctataata tgagagttat acattttggt gctggttctg ataaaggagt tgcaccaggt 6600
acagctgttt taagacagtg gttgcctacg ggtacgctgc ttgtcgattc agatcttaat 6660
gactttgtct ctgatgcaga ttcaactttg attggtgatt gtgcaactgt acatacagct 6720
aataaatggg atctcattat tagtgatatg tacgacccta agactaaaaa tgttacaaaa 6780
gaaaatgact ctaaagaggg ttttttcact tacatttgtg ggtttataca acaaaagcta 6840
gctcttggag gttccgtggc tataaagata acagaacatt cttggaatgc tgatctttat 6900
aagctcatgg gacacttcgc atggtggaca gcctttgtta ctaatgtgaa tgcgtcatca 6960
tctgaagcat ttttaattgg atgtaattat cttggcaaac cacgcgaaca aatagatggt 7020
tatgtcatgc atgcaaatta catattttgg aggaatacaa atccaattca gttgtcttcc 7080
tattctttat ttgacatgag taaatttccc cttaaattaa ggggtactgc tgttatgtct 7140
ttaaaagaag gtcaaatcaa tgatatgatt ttatctcttc ttagtaaagg tagacttata 7200
attagagaaa acaacagagt tgttatttct agtgatgttc ttgttaacaa ctaaacgaac 7260
aatgtttgtt tttcttgttt tattgccact agtctctagt cagtgtgtta atcttacaac 7320
cagaactcaa ttaccccctg catacactaa ttctttcaca cgtggtgttt attaccctga 7380
caaagttttc agatcctcag ttttacattc aactcaggac ttgttcttac ctttcttttc 7440
caatgttact tggttccatg ctatacatgt ctctgggacc aatggtacta agaggtttga 7500
taaccctgtc ctaccattta atgatggtgt ttattttgct tccactgaga agtctaacat 7560
aataagaggc tggatttttg gtactacttt agattcgaag acccagtccc tacttattgt 7620
taataacgct actaatgttg ttattaaagt ctgtgaattt caattttgta atgatccatt 7680
tttgggtgtt tattaccaca aaaacaacaa aagttggatg gaaagtgagt tcagagttta 7740
ttctagtgcg aataattgca cttttgaata tgtctctcag ccttttctta tggaccttga 7800
aggaaaacag ggtaatttca aaaatcttag ggaatttgtg tttaagaata ttgatggtta 7860
ttttaaaata tattctaagc acacgcctat taatttagtg cgtgatctcc ctcagggttt 7920
ttcggcttta gaaccattgg tagatttgcc aataggtatt aacatcacta ggtttcaaac 7980
tttacttgct ttacatagaa gttatttgac tcctggtgat tcttcttcag gttggacagc 8040
tggtgctgca gcttattatg tgggttatct tcaacctagg acttttctat taaaatataa 8100
tgaaaatgga accattacag atgctgtaga ctgtgcactt gaccctctct cagaaacaaa 8160
gtgtacgttg aaatccttca ctgtagaaaa aggaatctat caaacttcta actttagagt 8220
ccaaccaaca gaatctattg ttagatttcc taatattaca aacttgtgcc cttttggtga 8280
agtttttaac gccaccagat ttgcatctgt ttatgcttgg aacaggaaga gaatcagcaa 8340
ctgtgttgct gattattctg tcctatataa ttccgcatca ttttccactt ttaagtgtta 8400
tggagtgtct cctactaaat taaatgatct ctgctttact aatgtctatg cagattcatt 8460
tgtaattaga ggtgatgaag tcagacaaat cgctccaggg caaactggaa agattgctga 8520
ttataattat aaattaccag atgattttac aggctgcgtt atagcttgga attctaacaa 8580
tcttgattct aaggttggtg gtaattataa ttacctgtat agattgttta ggaagtctaa 8640
tctcaaacct tttgagagag atatttcaac tgaaatctat caggccggta gcacaccttg 8700
taatggtgtt gaaggtttta attgttactt tcctttacaa tcatatggtt tccaacccac 8760
taatggtgtt ggttaccaac catacagagt agtagtactt tcttttgaac ttctacatgc 8820
accagcaact gtttgtggac ctaaaaagtc tactaatttg gttaaaaaca aatgtgtcaa 8880
tttcaacttc aatggtttaa caggcacagg tgttcttact gagtctaaca aaaagtttct 8940
gcctttccaa caatttggca gagacattgc tgacactact gatgctgtcc gtgatccaca 9000
gacacttgag attcttgaca ttacaccatg ttcttttggt ggtgtcagtg ttataacacc 9060
aggaacaaat acttctaacc aggttgctgt tctttatcag gatgttaact gcacagaagt 9120
ccctgttgct attcatgcag atcaacttac tcctacttgg cgtgtttatt ctacaggttc 9180
taatgttttt caaacacgtg caggctgttt aataggggct gaacatgtca acaactcata 9240
tgagtgtgac atacccattg gtgcaggtat atgcgctagt tatcagactc agactaattc 9300
tcctcggcgg gcacgtagtg tagctagtca atccatcatt gcctacacta tgtcacttgg 9360
tgcagaaaat tcagttgctt actctaataa ctctattgcc atacccacaa attttactat 9420
tagtgttacc acagaaattc taccagtgtc tatgaccaag acatcagtag attgtacaat 9480
gtacatttgt ggtgattcaa ctgaatgcag caatcttttg ttgcaatatg gcagtttttg 9540
tacacaatta aaccgtgctt taactggaat agctgttgaa caagacaaaa acacccaaga 9600
agtttttgca caagtcaaac aaatttacaa aacaccacca attaaagatt ttggtggttt 9660
taatttttca caaatattac cagatccatc aaaaccaagc aagaggtcat ttattgaaga 9720
tctacttttc aacaaagtga cacttgcaga tgctggcttc atcaaacaat atggtgattg 9780
ccttggtgat attgctgcta gagacctcat ttgtgcacaa aagtttaacg gccttactgt 9840
tttgccacct ttgctcacag atgaaatgat tgctcaatac acttctgcac tgttagcggg 9900
tacaatcact tctggttgga cctttggtgc aggtgctgca ttacaaatac catttgctat 9960
gcaaatggct tataggttta atggtattgg agttacacag aatgttctct atgagaacca 10020
aaaattgatt gccaaccaat ttaatagtgc tattggcaaa attcaagact cactttcttc 10080
cacagcaagt gcacttggaa aacttcaaga tgtggtcaac caaaatgcac aagctttaaa 10140
cacgcttgtt aaacaactta gctccaattt tggtgcaatt tcaagtgttt taaatgatat 10200
cctttcacgt cttgacaaag ttgaggctga agtgcaaatt gataggttga tcacaggcag 10260
acttcaaagt ttgcagacat atgtgactca acaattaatt agagctgcag aaatcagagc 10320
ttctgctaat cttgctgcta ctaaaatgtc agagtgtgta cttggacaat caaaaagagt 10380
tgatttttgt ggaaagggct atcatcttat gtccttccct cagtcagcac ctcatggtgt 10440
agtcttcttg catgtgactt atgtccctgc acaagaaaag aacttcacaa ctgctcctgc 10500
catttgtcat gatggaaaag cacactttcc tcgtgaaggt gtctttgttt caaatggcac 10560
acactggttt gtaacacaaa ggaattttta tgaaccacaa atcattacta cagacaacac 10620
atttgtgtct ggtaactgtg atgttgtaat aggaattgtc aacaacacag tttatgatcc 10680
tttgcaacct gaattagact cattcaagga ggagttagat aaatatttta agaatcatac 10740
atcaccagat gttgatttag gtgacatctc tggcattaat gcttcagttg taaacattca 10800
aaaagaaatt gaccgcctca atgaggttgc caagaattta aatgaatctc tcatcgatct 10860
ccaagaactt ggaaagtatg agcagtatat aaaatggcca tggtacattt ggctaggttt 10920
tatagctggc ttgattgcca tagtaatggt gacaattatg ctttgctgta tgaccagttg 10980
ctgtagttgt ctcaagggct gttgttcttg tggatcctgc tgcaaatttg atgaagacga 11040
ctctgagcca gtgctcaaag gagtcaaatt acattacaca taaacgaact tatggatttg 11100
tttatgagaa tcttcacaat tggaactgta actttgaagc aaggtgaaat caaggatgct 11160
actccttcag attttgttcg cgctactgca acgataccga tacaagcctc actccctttc 11220
ggatggctta ttgttggcgt tgcacttctt gctgtttttc agagcgcttc caaaatcata 11280
accctcaaaa agagatggca actagcactc tccaagggtg ttcactttgt ttgcaacttg 11340
ctgttgttgt ttgtaacagt ttactcacac cttttgctcg ttgctgctgg ccttgaagcc 11400
ccttttctct atctttatgc tttagtctac ttcttgcaga gtataaactt tgtaagaata 11460
ataatgaggc tttggctttg ctggaaatgc cgttccaaaa acccattact ttatgatgcc 11520
aactattttc tttgctggca tactaattgt tacgactatt gtatacctta caatagtgta 11580
acttcttcaa ttgtcattac ttcaggtgat ggcacaacaa gtcctatttc tgaacatgac 11640
taccagattg gtggttatac tgaaaaatgg gaatctggag taaaagactg tgttgtatta 11700
cacagttact tcacttcaga ctattaccag ctgtactcaa ctcaattgag tacagacact 11760
ggtgttgaac atgttacctt cttcatctac aataaaattg ttgatgagcc tgaagaacat 11820
gtccaaattc acacaatcga cggttcatcc ggagttgtta atccagtaat ggaaccaatt 11880
tatgatgaac cgacgacgac tactagcgtg cctttgtaag cacaagctga tgagtacgaa 11940
cttatgtact cattcgtttc ggaagagaca ggtacgttaa tagttaatag cgtacttctt 12000
tttcttgctt tcgtggtatt cttgctagtt acactagcca tccttactgc gcttcgattg 12060
tgtgcgtact gctgcaatat tgttaacgtg agtcttgtaa aaccttcttt ttacgtttac 12120
tctcgtgtta aaaatctgaa ttcttctaga gttcctgatc ttctggtcta aacgaactaa 12180
atattatatt agtttttctg tttggaactt taattttagc catggcagat tccaacggta 12240
ctattaccgt tgaagagctt aaaaagctcc ttgaacaatg gaacctagta ataggtttcc 12300
tattccttac atggatttgt cttctacaat ttgcctatgc caacaggaat aggtttttgt 12360
atataattaa gttaattttc ctctggctgt tatggccagt aactttagct tgttttgtgc 12420
ttgctgctgt ttacagaata aattggatca ccggtggaat tgctatcgca atggcttgtc 12480
ttgtaggctt gatgtggctc agctacttca ttgcttcttt cagactgttt gcgcgtacgc 12540
gttccatgtg gtcattcaat ccagaaacta acattcttct caacgtgcca ctccatggca 12600
ctattctgac cagaccgctt ctagaaagtg aactcgtaat cggagctgtg atccttcgtg 12660
gacatcttcg tattgctgga caccatctag gacgctgtga catcaaggac ctgcctaaag 12720
aaatcactgt tgctacatca cgaacgcttt cttattacaa attgggagct tcgcagcgtg 12780
tagcaggtga ctcaggtttt gctgcataca gtcgctacag gattggcaac tataaattaa 12840
acacagacca ttccagtagc agtgacaata ttgctttgct tgtacagtaa gtgacaacag 12900
atgtttcatc tcgttgactt tcaggttact atagcagaga tattactaat tattatgagg 12960
acttttaaag tttccatttg gaatcttgat tacatcataa acctcataat taaaaattta 13020
tctaagtcac taactgagaa taaatattct caattagatg aagagcaacc aatggagatt 13080
gattaaacga acatgaaaat tattcttttc ttggcactga taacactcgc tacttgtgag 13140
ctttatcact accaagagtg tgttagaggt acaacagtac ttttaaaaga accttgctct 13200
tctggaacat acgagggcaa ttcaccattt catcctctag ctgataacaa atttgcactg 13260
acttgcttta gcactcaatt tgcttttgct tgtcctgacg gcgtaaaaca cgtctatcag 13320
ttacgtgcca gatcagtttc acctaaactg ttcatcagac aagaggaagt tcaagaactt 13380
tactctccaa tttttcttat tgttgcggca atagtgttta taacactttg cttcacactc 13440
aaaagaaaga cagaatgatt gaactttcat taattgactt ctatttgtgc tttttagcct 13500
ttctgctatt ccttgtttta attatgctta ttatcttttg gttctcactt gaactgcaag 13560
atcataatga aacttgtcac gcctaaacga acatgaaatt tcttgttttc ttaggaatca 13620
tcacaactgt agctgcattt caccaagaat gtagtttaca gtcatgtact caacatcaac 13680
catatgtagt tgatgacccg tgtcctattc acttctattc taaatggtat attagagtag 13740
gagctagaaa atcagcacct ttaattgaat tgtgcgtgga tgaggctggt tctaaatcac 13800
ccattcagta catcgatatc ggtaattata cagtttcctg tttacctttt acaattaatt 13860
gccaggaacc taaattgggt agtcttgtag tgcgttgttc gttctatgaa gactttttag 13920
agtatcatga cgttcgtgtt gttttagatt tcatctaaac gaacaaacta aaatgtctga 13980
taatggaccc caaaatcagc gaaatgcacc ccgcattacg tttggtggac cctcagattc 14040
aactggcagt aaccagaatg gagaacgcag tggggcgcga tcaaaacaac gtcggcccca 14100
aggtttaccc aataatactg cgtcttggtt caccgctctc actcaacatg gcaaggaaga 14160
ccttaaattc cctcgaggac aaggcgttcc aattaacacc aatagcagtc cagatgacca 14220
aattggctac taccgaagag ctaccagacg aattcgtggt ggtgacggta aaatgaaaga 14280
tctcagtcca agatggtatt tctactacct aggaactggg ccagaagctg gacttcccta 14340
tggtgctaac aaagacggca tcatatgggt tgcaactgag ggagccttga atacaccaaa 14400
agatcacatt ggcacccgca atcctgctaa caatgctgca atcgtgctac aacttcctca 14460
aggaacaaca ttgccaaaag gcttctacgc agaagggagc agaggcggca gtcaagcctc 14520
ttctcgttcc tcatcacgta gtcgcaacag ttcaagaaat tcaactccag gcagcagtag 14580
gggaacttct cctgctagaa tggctggcaa tggcggtgat gctgctcttg ctttgctgct 14640
gcttgacaga ttgaaccagc ttgagagcaa aatgtctggt aaaggccaac aacaacaagg 14700
ccaaactgtc actaagaaat ctgctgctga ggcttctaag aagcctcggc aaaaacgtac 14760
tgccactaaa gcatacaatg taacacaagc tttcggcaga cgtggtccag aacaaaccca 14820
aggaaatttt ggggaccagg aactaatcag acaaggaact gattacaaac attggccgca 14880
aattgcacaa tttgccccca gcgcttcagc gttcttcgga atgtcgcgca ttggcatgga 14940
agtcacacct tcgggaacgt ggttgaccta cacaggtgcc atcaaattgg atgacaaaga 15000
tccaaatttc aaagatcaag tcattttgct gaataagcat attgacgcat acaaaacatt 15060
cccaccaaca gagcctaaaa aggacaaaaa gaagaaggct gatgaaactc aagccttacc 15120
gcagagacag aagaaacagc aaactgtgac tcttcttcct gctgcagatt tggatgattt 15180
ctccaaacaa ttgcaacaat ccatgagcag tgctgactca actcaggcct aaactcatgc 15240
agaccacaca aggcagatgg gctatataaa cgttttcgct tttccgttta cgatatatag 15300
tctactcttg tgcagaatga attctcgtaa ctacatagca caagtagatg tagttaactt 15360
taatctcaca tagcaatctt taatcagtgt gtaacattag ggaggacttg aaagagccac 15420
cacattttca ccgaggccac gcggagtacg atcgagtgta cagtgaacaa tgctagggag 15480
agctgcctat atggaagagc cctaatgtgt aaaattaatt ttagtagtgc tatccccatg 15540
tgattttaat agcttcttag gagaatgaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 15600
aa 15602
Claims (51)
1.一种产生缺陷干扰病毒基因组(DVG)的方法,所述方法包括:
提供第一组至少三种复制的体外细胞培养物,其包含固体载体和以高感染复数(MOI)感染参照感染性病毒的细胞;
提供第二组至少三种复制的体外细胞培养物,其包含固体载体和以低感染复数(MOI)感染参照感染性病毒的细胞;
在诱变条件下,将第一组和第二组复制的体外细胞培养物培养至少5代;
从第一组和第二组体外复制的细胞培养物的培养基中收集多种DVG候选;
对所收集的DVG候选进行深度测序;和
从所述多种DVG候选中选择DVG。
2.根据权利要求1所述的方法,所述方法还包括:
提供第三组至少三种复制的体外细胞培养物,其包含固体载体和以高感染复数(MOI)感染参照感染性病毒的细胞;和/或
提供第四组至少三种复制的体外细胞培养物,其包含固体载体和以低感染复数(MOI)感染参照感染性病毒的细胞;和
在非诱变条件下,将第三组和/或第四组复制的体外细胞培养物培养至少5代。
3.根据权利要求1或2所述的方法,其中,从所述多种DVG候选中选择DVG包括:
将所述DVG候选的序列与所述参照感染性病毒的基因组序列进行比较;
识别具有包含至少一个剪接事件的基因组的至少一种DVG候选,其中所述剪接事件是缺失或重排;
在已测序的DVG候选基因组群中确定具有至少一个剪接事件的基因组的至少一种DVG候选的相对频率;和,
选择至少一种DVG,其中:
a)至少一个剪接事件在高MOI培养物中比在低MOI培养物中更丰富;和/或
b)至少一个剪接事件出现在至少2、3、4、5、6、7、8或9种不同的细胞系中;和/或,
c)在至少5、10、15或20次传代后,在至少12、24或36次独立复制的至少3次中发现至少一个剪接事件;和/或,
d)至少一个剪接事件是缺失事件,并且所述缺失的核苷酸大小是至少40、42、50、100、150、200、400、600或1000个核苷酸;和/或,
e)保持所述DVG中的开放阅读框;和/或,
f)病毒复制所需的结构域和功能在所述DVG中保持;和/或
g)所述DVG包含至少一种降低所述参照感染性病毒自我复制能力的突变。
4.根据权利要求1至3中任一项所述的方法,其中,所述DVG的特征在于对所述参照感染性病毒的体外抑制活性为至少50%、60%、70%、80%或90%。
5.根据权利要求1至4中任一项所述的方法,其中,所述参照感染性病毒具有增变基因表型。
6.根据权利要求1至5中任一项所述的方法,其中,所述参照感染性病毒为基孔肯雅病毒(CHIKV)、寨卡病毒(ZIKV)、肠道病毒71型(EV71)、鼻病毒(RV)、黄热病病毒(YFV)、西尼罗河病毒(WNV)或冠状病毒(CV)。
7.根据权利要求1至5中任一项所述的方法,其中,所述参照感染性病毒选自由以下组成的组:CHIKV印度洋谱系(GenBank登录号AM258994)、CHIKV加勒比海毒株(GenBank登录号LN898104.1)、ZIKV非洲毒株MR766(KY989511.1)、EV71 Sep006(GenBank:KX197462.1)、RV-A01a(NC_038311.1)、RV-A16(L24917.1)、RV-B14(L05355.1)、RV-C15(GU219984.1)、西尼罗河病毒以色列1998和YFV毒株,黄热病病毒Asibi(YF-Asibi)毒株、黄热病毒疫苗(YF-17D)毒株和冠状病毒SARS-CoV-2毒株。
8.根据权利要求1至7中任一项所述的方法,其中,所述细胞为哺乳动物细胞系,所述哺乳动物细胞系选自由以下组成的组:源自非洲绿猴肾细胞的细胞系(可选Vero,可选Vero-E6细胞系)、源自人类肌肉的细胞系(可选RD细胞系)、源自幼仓鼠肾的细胞系(可选BHK细胞系)、源自人类胚胎肾细胞的细胞系(可选HEK293T细胞系)、源自肝癌细胞的细胞系(可选Huh7细胞系)和源自宫颈腺癌的细胞系(可选H1-HeLa,可选HeLa-E8细胞系)。
9.根据权利要求1至7中任一项所述的方法,其中,所述细胞为蚊子细胞系,所述蚊子细胞系选自由以下组成的组:源自埃及伊蚊(Aedes aegypti)的细胞系(可选Aag2细胞系)、源自白纹伊蚊(Aedes albopictus)的细胞(可选C6/36细胞系)和源自白纹伊蚊的细胞系(可选U4.4细胞系)。
10.根据权利要求1至9中任一项所述的方法,其中,所述用于感染的低MOI为0.001至0.1PFU/细胞,特别为0.01至0.1PFU/细胞。
11.根据权利要求1至10中任一项所述的方法,其中,所述用于感染的高MOI为1PFU/细胞至100PFU/细胞,特别为5至50PFU/细胞或5至20PFU/细胞。
12.一种根据权利要求1至11中任一项所述的方法产生的DVG。
13.一种DVG,所述DVG包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:1(DG1:EV71 DVG293-390)、SEQ ID NO:2(DG2:EV71 DVG294-404)、SEQ ID NO:3(DG3:EV71 DVG 1746-2895)、SEQ ID NO:4(DG4:EV71 DVG 1752-2894)、SEQ ID NO:5(DG5:EV71 DVG 1752-2896)、SEQ ID NO:6(DG6:EV71 DVG1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQ ID NO:8(DG8:EV71 DVG 3513-6516)、SEQID NO:9(DG9:EV71 DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG 5610-6876)、SEQ IDNO:11(DG11:EV71DVG 5610-6877)、SEQ ID NO:12(DG12:EV71 DVG 5746-5821)、SEQ IDNO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71 DVG6322-6358)、SEQ IDNO:15(DG15:EV71 DVG 6728-6779)、SEQ ID NO:16(DG16:EV71 DVG 6966-7012)、SEQ IDNO:17(DG17:EV71 DVG6966-7014)、SEQ ID NO:18(DG18:EV71 DVG 7098-7122)、SEQ IDNO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71 DVG7165-7201)、SEQ IDNO:21(DG21:EV71 DVG 7238-7292)、SEQ ID NO:22(ZIKV DVG-A)、SEQ ID NO:23(ZIKVDVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ ID NO:26(ZIKVDVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ ID NO:29(ZIKVDVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ ID NO:32(ZIKVDVG-K)、SEQ ID NO:33(ZIKV DVG-L)、SEQ ID NO:34(CHIKV DVG-IV1)、SEQ ID NO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKV DVG-IV4)、SEQID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKV DVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQ ID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:45(CHIKV DVG-CH2)、SEQID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)、SEQ ID NO:53(CHIKV DVG-CA4)、SEQID NO:55(RV DVG A01a-TIP-01)、SEQ ID NO:56(RV DVG A01a-TIP-02)、SEQ ID NO:57(RVDVG A01a-TIP-03)、SEQ ID NO:58(RV DVG A01a-TIP-04)、SEQ ID NO:59(RV DVG A01a-TIP-05)、SEQ ID NO:60(RV DVG A01a-TIP-06)、SEQ ID NO:62(RV DVG A16-TIP-01)、SEQID NO:63(RV DVG A16-TIP-02)、SEQ ID NO:64(RV DVG A16-TIP-03)、SEQ ID NO:65(RVDVG A16-TIP-04)、SEQ ID NO:66(RV DVG A16-TIP-05)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ ID NO:91(RV DVG C15-TIP-03),SEQ IDNO:92(RV DVG C15-TIP-04)、SEQ ID NO:68(RV DVG B14-TIP-01)、SEQ ID NO:69(RV DVGB14-TIP-02)、SEQ ID NO:70(RV DVG B14-TIP-03)、SEQ ID NO:71(RV DVG B14-TIP-04)、SEQ ID NO:72(RV DVG B14-TIP-05)、SEQ ID NO:73(RV DVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ ID NO:75(RV DVG B14-TIP-08)、SEQ ID NO:76(RV DVG B14-TIP-09)、SEQ ID NO:77(RV DVG B14-TIP-10)、SEQ ID NO:78(RV DVG B14-TIP-11)、SEQID NO:79(RV DVG B14-TIP-12)、SEQ ID NO:80(RV DVG B14-TIP-13)、SEQ ID NO:81(RVDVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ ID NO:83(RV DVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ ID NO:85(RV DVG B14-TIP-18)、SEQ IDNO:86(RV DVG B14-TIP-19)、SEQ ID NO:87(RV DVG B14-TIP-20)、SEQ ID NO:93(YFVDVG-A)、SEQ ID NO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQ ID NO:96(YFV DVG-D)、SEQ ID NO:97(YFV DVG-E)、SEQ ID NO:98(YFV DVG-F)、SEQ ID NO:99(YFV DVG-G)、SEQ ID NO:100(YFV DVG-H)、SEQ ID NO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFV DVG-K)、SEQ ID NO:104(YFV DVG-L),SEQ ID NO:105(WNV DVG-1),SEQ ID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ ID NO:109(WNV DVG-5)、SEQ ID NO:110(WNV DVG-6)、SEQ ID NO:111(SARS-CoV-2DVG_1)、SEQ ID NO:112(SARS-CoV-2DVG_2)和SEQ ID NO:113(SARS-CoV-2DVG_3),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的核苷酸序列。
14.一种缺陷干扰粒子,所述缺陷干扰粒子包含权利要求12或13所述的DVG。
15.一种治疗受试者病毒感染的方法,所述方法包括施用治疗有效量的至少一种根据权利要求12至14中任一项所述的DVG或缺陷干扰粒子。
16.根据权利要求15所述的方法,其中,所述DVG作为裸RNA施用。
17.根据权利要求15所述的方法,其中,至少一种DVG是缺陷干扰CHIKV基因组。
18.根据权利要求17所述的方法,其中,至少一种缺陷干扰CHIKV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:34(CHIKV DVG-IV1)、SEQ ID NO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQID NO:37(CHIKV DVG-IV4)、SEQ ID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKV DVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQ ID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQID NO:45(CHIKV DVG-CH2)、SEQ ID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)和SEQID NO:53(CHIKV DVG-CA4)。
19.根据权利要求15所述的方法,其中,至少一种缺陷干扰基因组是缺陷干扰ZIKV基因组。
20.根据权利要求19所述的方法,其中,至少一种干扰ZIKV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:22(ZIKV DVG-A)、SEQ ID NO:23(ZIKV DVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ ID NO:26(ZIKV DVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ ID NO:29(ZIKV DVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ ID NO:32(ZIKV DVG-K)和SEQ ID NO:33(ZIKV DVG-L),特别是SEQ ID NO:32(ZIKVDVG-K)。
21.根据权利要求15所述的方法,其中,至少一种缺陷干扰基因组是缺陷干扰EV71基因组。
22.根据权利要求21所述的方法,其中,至少一种缺陷干扰EV71基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:1(DG1:EV71 DVG 293-390)、SEQ ID NO:2(DG2:EV71 DVG 294-404)、SEQ ID NO:3(DG3:EV71 DVG1746-2895)、SEQ ID NO:4(DG4:EV71 DVG 1752-2894)、SEQ ID NO:5(DG5:EV71DVG 1752-2896)、SEQ ID NO:6(DG6:EV71 DVG 1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQ ID NO:8(DG8:EV71 DVG3513-6516)、SEQ ID NO:9(DG9:EV71 DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG 5610-6876)、SEQ ID NO:11(DG11:EV71 DVG5610-6877)、SEQ ID NO:12(DG12:EV71 DVG 5746-5821)、SEQ ID NO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71 DVG6322-6358)、SEQ ID NO:15(DG15:EV71 DVG 6728-6779)、SEQ ID NO:16(DG16:EV71 DVG 6966-7012)、SEQ ID NO:17(DG17:EV71 DVG6966-7014)、SEQ ID NO:18(DG18:EV71 DVG 7098-7122)、SEQ ID NO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71 DVG7165-7201)和SEQ ID NO:21(DG21:EV71 DVG 7238-7292)。
23.根据权利要求15所述的方法,其中,至少一种缺陷干扰基因组是缺陷干扰RV基因组。
24.根据权利要求23所述的方法,其中,至少一种缺陷干扰RV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:55(RVDVGA01a-TIP-01)、SEQ ID NO:56(RV DVGA01a-TIP-02)、SEQ ID NO:57(RV DVGA01a-TIP-03)、SEQ ID NO:58(RV DVGA01a-TIP-04)、SEQ ID NO:59(RV DVGA01a-TIP-05)、SEQ IDNO:60(RV DVGA01a-TIP-06)、SEQ ID NO:62(RV DVGA16-TIP-01)、SEQ ID NO:63(RVDVGA16-TIP-02)、SEQ ID NO:64(RV DVGA16-TIP-03)、SEQ ID NO:65(RV DVGA16-TIP-04)、SEQ ID NO:66(RV DVG A16-TIP-05)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ ID NO:91(RV DVG C15-TIP-03)、SEQ ID NO:92(RV DVG C15-TIP-04)、SEQ ID NO:68(RV DVG B14-TIP-01)、SEQ ID NO:69(RV DVG B14-TIP-02)、SEQID NO:70(RV DVG B14-TIP-03)、SEQ ID NO:71(RV DVG B14-TIP-04)、SEQ ID NO:72(RVDVG B14-TIP-05)、SEQ ID NO:73(RV DVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ ID NO:75(RV DVG B14-TIP-08)、SEQ ID NO:76(RV DVG B14-TIP-09)、SEQ IDNO:77(RV DVG B14-TIP-10)、SEQ ID NO:78(RV DVG B14-TIP-11)、SEQ ID NO:79(RV DVGB14-TIP-12)、SEQ ID NO:80(RV DVG B14-TIP-13)、SEQ ID NO:81(RV DVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ ID NO:83(RV DVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ ID NO:85(RV DVG B14-TIP-18)、SEQ ID NO:86(RV DVG B14-TIP-19)和SEQ ID NO:87(RV DVG B14-TIP-20)。
25.根据权利要求15所述的方法,其中,所述至少一种缺陷干扰基因组是缺陷干扰YFV基因组。
26.根据权利要求25所述的方法,其中,所述至少一种缺陷干扰YFV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:93(YFV DVG-A)、SEQ ID NO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQ ID NO:96(YFVDVG-D)、SEQ ID NO:97(YFV DVG-E)、SEQ ID NO:98(YFV DVG-F)、SEQ ID NO:99(YFV DVG-G)、SEQ ID NO:100(YFV DVG-H)、SEQ ID NO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFV DVG-K)和SEQ ID NO:104(YFV DVG-L)。
27.根据权利要求15所述的方法,其中,所述至少一种缺陷干扰基因组是缺陷干扰WNV基因组。
28.根据权利要求27所述的方法,其中,所述至少一种缺陷干扰WNV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:105(WNV DVG-1)、SEQ ID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ ID NO:109(WNV DVG-5)和SEQ ID NO:110(WNV DVG-6)。
29.根据权利要求15所述的方法,其中,所述至少一种缺陷干扰基因组是缺陷干扰CV基因组。
30.根据权利要求29所述的方法,其中,所述至少一种缺陷干扰CV基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:111(SARS-CoV-2DVG_1)、SEQ ID NO:112(SARS-CoV-2DVG_2)和SEQ ID NO:113(SARS-CoV-2DVG_3)。
31.根据权利要求12至14中任一项所述的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者CHIKV感染的方法,特别是其中,所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:34(CHIKV DVG-IV1)、SEQ ID NO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKVDVG-IV4)、SEQ ID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQ ID NO:40(CHIKV DVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:45(CHIKV DVG-CH2)、SEQ ID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQ ID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)和SEQ ID NO:53(CHIKV DVG-CA4)。
32.根据权利要求12至14中任一项所述的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者ZIKV感染的方法,特别是其中,所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:22(ZIKV DVG-A)、SEQID NO:23(ZIKV DVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ IDNO:26(ZIKV DVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ IDNO:29(ZIKV DVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ IDNO:32(ZIKV DVG-K)和SEQ ID NO:33(ZIKV DVG-L)。
33.根据权利要求12至14中任一项所述的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者EV71感染的方法,特别是其中,所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:1(DG1:EV71 DVG293-390)、SEQ ID NO:2(DG2:EV71 DVG 294-404)、SEQ ID NO:3(DG3:EV71 DVG 1746-2895)、SEQ ID NO:4(DG4:EV71 DVG 1752-2894)、SEQ ID NO:5(DG5:EV71DVG 1752-2896)、SEQ ID NO:6(DG6:EV71 DVG 1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQID NO:8(DG8:EV71 DVG3513-6516)、SEQ ID NO:9(DG9:EV71 DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG 5610-6876)、SEQ ID NO:11(DG11:EV71 DVG5610-6877)、SEQ ID NO:12(DG12:EV71 DVG 5746-5821)、SEQ ID NO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71 DVG6322-6358)、SEQ ID NO:15(DG15:EV71 DVG 6728-6779)、SEQ ID NO:16(DG16:EV71 DVG 6966-7012)、SEQ ID NO:17(DG17:EV71 DVG6966-7014)、SEQ ID NO:18(DG18:EV71 DVG 7098-7122)、SEQ ID NO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71 DVG7165-7201)和SEQ ID NO:21(DG21:EV71 DVG 7238-7292)。
34.根据权利要求12至14中任一项所述的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者RV感染的方法,特别是其中,所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:55(RV DVGA01a-TIP-01)、SEQ ID NO:56(RV DVGA01a-TIP-02)、SEQ ID NO:57(RV DVGA01a-TIP-03)、SEQ IDNO:58(RV DVGA01a-TIP-04)、SEQ ID NO:59(RV DVGA01a-TIP-05)、SEQ ID NO:60(RVDVGA01a-TIP-06)、SEQ ID NO:62(RV DVG A16-TIP-01)、SEQ ID NO:63(RV DVGA16-TIP-02)、SEQ ID NO:64(RV DVGA16-TIP-03)、SEQ ID NO:65(RV DVGA16-TIP-04)、SEQ ID NO:66(RV DVGA16-TIP-05)、SEQ ID NO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ ID NO:91(RV DVG C15-TIP-03)、SEQ ID NO:92(RV DVG C15-TIP-04)、SEQID NO:68(RV DVG B14-TIP-01)、SEQ ID NO:69(RV DVG B14-TIP-02)、SEQ ID NO:70(RVDVG B14-TIP-03)、SEQ ID NO:71(RV DVG B14-TIP-04)、SEQ ID NO:72(RV DVG B14-TIP-05)、SEQ ID NO:73(RV DVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ IDNO:75(RV DVG B14-TIP-08)、SEQ ID NO:76(RV DVG B14-TIP-09)、SEQ ID NO:77(RV DVGB14-TIP-10)、SEQ ID NO:78(RV DVG B14-TIP-11)、SEQ ID NO:79(RV DVG B14-TIP-12)、SEQ ID NO:80(RV DVG B14-TIP-13)、SEQ ID NO:81(RV DVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ ID NO:83(RV DVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ ID NO:85(RV DVG B14-TIP-18)、SEQ ID NO:86(RV DVG B14-TIP-19)和SEQID NO:87(RV DVG B14-TIP-20)。
35.根据权利要求12至14中任一项所述的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者YFV感染的方法,特别是其中,所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:93(YFV DVG-A)、SEQ IDNO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQ ID NO:96(YFV DVG-D)、SEQ ID NO:97(YFV DVG-E)、SEQ ID NO:98(YFV DVG-F)、SEQ ID NO:99(YFV DVG-G)、SEQ ID NO:100(YFVDVG-H)、SEQ ID NO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFVDVG-K)和SEQ ID NO:104(YFV DVG-L)。
36.根据权利要求12至14中任一项所述的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者WNV感染的方法,特别是其中,所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:105(WNV DVG-1)、SEQID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ IDNO:109(WNV DVG-5)和SEQ ID NO:110(WNV DVG-6)。
37.根据权利要求12至14中任一项所述的缺陷干扰基因组DVG或缺陷干扰粒子用于治疗受试者CV感染、特别是受试者SARS-CoV-2感染的方法,特别是其中,所述缺陷干扰基因组包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQID NO:111(SARS-CoV-2DVG_1)、SEQ ID NO:112(SARS-CoV-2DVG_2)和SEQ ID NO:113(SARS-CoV-2DVG_3)。
38.一种药物组合物、免疫原性组合物或治疗组合物,所述药物组合物、免疫原性组合物或治疗组合物包含至少一种根据权利要求12或13所述的DVG,和药学上可接受的载体。
39.一种药物组合物、免疫原性组合物或治疗组合物,所述药物组合物、免疫原性组合物或治疗组合物包含至少一种根据权利要求14所述的缺陷干扰粒子,和药学上可接受的载体。
40.一种疫苗,所述疫苗包含根据权利要求38或39所述的组合物。
41.根据权利要求12或13所述的DVG或根据权利要求14所述的缺陷干扰粒子在制备用于治疗感染DVG或缺陷干扰粒子的靶病毒的患者的药物中的用途。
42.根据权利要求12或13所述的DVG或根据权利要求14所述的缺陷干扰粒子在制备用于治疗感染CHIKV的患者的药物中的用途。
43.根据权利要求12或13所述的DVG或根据权利要求14所述的缺陷干扰粒子在制备用于治疗感染ZIKV的患者的药物中的用途。
44.根据权利要求12或13所述的DVG或根据权利要求14所述的缺陷干扰粒子在制备用于治疗感染EV71的患者的药物中的用途。
45.根据权利要求12或13所述的DVG或根据权利要求14所述的缺陷干扰粒子在制备用于治疗感染RV的患者的药物中的用途。
46.根据权利要求12或13所述的DVG或根据权利要求14所述的缺陷干扰粒子在制备用于治疗感染YFV的患者的药物中的用途。
47.根据权利要求12或13所述的DVG或根据权利要求14所述的缺陷干扰粒子在制备用于治疗感染WNV的患者的药物中的用途。
48.根据权利要求12或13所述的DVG或根据权利要求14所述的缺陷干扰粒子在制备用于治疗感染CV、特别是SARS-CoV-2的患者的药物中的用途。
49.一种多核苷酸,所述多核苷酸包含选自由以下组成的组的核苷酸序列或由选自由以下组成的组的核苷酸序列组成:SEQ ID NO:1(DG1:EV71 DVG 293-390)、SEQ ID NO:2(DG2:EV71 DVG 294-404)、SEQ ID NO:3(DG3:EV71 DVG 1746-2895)、SEQ ID NO:4(DG4:EV71 DVG1752-2894)、SEQ ID NO:5(DG5:EV71 DVG 1752-2896)、SEQ ID NO:6(DG6:EV71DVG 1880-6487)、SEQ ID NO:7(DG7:EV71 DVG 1880-6488)、SEQ ID NO:8(DG8:EV71 DVG3513-6516)、SEQ ID NO:9(DG9:EV71DVG 5475-5634)、SEQ ID NO:10(DG10:EV71 DVG5610-6876)、SEQ ID NO:11(DG11:EV71 DVG 5610-6877)、SEQ ID NO:12(DG12:EV71DVG5746-5821)、SEQ ID NO:13(DG13:EV71 DVG 6322-6356)、SEQ ID NO:14(DG14:EV71DVG 6322-6358)、SEQ ID NO:15(DG15:EV71 DVG6728-6779)、SEQ ID NO:16(DG16:EV71DVG 6966-7012)、SEQ ID NO:17(DG17:EV71 DVG 6966-7014)、SEQ ID NO:18(DG18:EV71DVG7098-7122)、SEQ ID NO:19(DG19:EV71 DVG 7165-7200)、SEQ ID NO:20(DG20:EV71DVG 7165-7201)、SEQ ID NO:21(DG21:EV71 DVG7238-7292)、SEQ ID NO:22(ZIKV DVG-A)、SEQ ID NO:23(ZIKV DVG-B)、SEQ ID NO:24(ZIKV DVG-C)、SEQ ID NO:25(ZIKV DVG-D)、SEQ ID NO:26(ZIKV DVG-E)、SEQ ID NO:27(ZIKV DVG-F)、SEQ ID NO:28(ZIKV DVG-G)、SEQ ID NO:29(ZIKV DVG-H)、SEQ ID NO:30(ZIKV DVG-I)、SEQ ID NO:31(ZIKV DVG-J)、SEQ ID NO:32(ZIKV DVG-K)、SEQ ID NO:33(ZIKV DVG-L)、SEQ ID NO:34(CHIKV DVG-IV1)、SEQ ID NO:35(CHIKV DVG-IV2)、SEQ ID NO:36(CHIKV DVG-IV3)、SEQ ID NO:37(CHIKV DVG-IV4)、SEQ ID NO:38(CHIKV DVG-IH1)、SEQ ID NO:39(CHIKV DVG-IU1)、SEQID NO:40(CHIKV DVG-CV1)、SEQ ID NO:41(CHIKV DVG-CV2)、SEQ ID NO:42(CHIKV DVG-CV3)、SEQ ID NO:43(CHIKV DVG-CV4)、SEQ ID NO:44(CHIKV DVG-CH1)、SEQ ID NO:45(CHIKV DVG-CH2)、SEQ ID NO:46(CHIKV DVG-CH3)、SEQ ID NO:47(CHIKV DVG-CM1)、SEQID NO:48(CHIKV DVG-CU1)、SEQ ID NO:49(CHIKV DVG-CU2)、SEQ ID NO:50(CHIKV DVG-CA1)、SEQ ID NO:51(CHIKV DVG-CA2)、SEQ ID NO:52(CHIKV DVG-CA3)、SEQ ID NO:53(CHIKV DVG-CA4)、SEQ ID NO:55(RV DVG A01a-TIP-01)、SEQ ID NO:56(RV DVG A01a-TIP-02)、SEQ ID NO:57(RV DVG A01a-TIP-03)、SEQ ID NO:58(RV DVG A01a-TIP-04)、SEQID NO:59(RV DVG A01a-TIP-05)、SEQ ID NO:60(RV DVG A01a-TIP-06)、SEQ ID NO:62(RVDVG A16-TIP-01)、SEQ ID NO:63(RV DVG A16-TIP-02)、SEQ ID NO:64(RV DVG A16-TIP-03)、SEQ ID NO:65(RV DVG A16-TIP-04)、SEQ ID NO:66(RV DVG A16-TIP-05)、SEQ IDNO:89(RV DVG C15-TIP-01)、SEQ ID NO:90(RV DVG C15-TIP-02)、SEQ ID NO:91(RV DVGC15-TIP-03)、SEQ ID NO:92(RV DVG C15-TIP-04)、SEQ ID NO:68(RV DVG B14-TIP-01)、SEQ ID NO:69(RV DVG B14-TIP-02)、SEQ ID NO:70(RV DVG B14-TIP-03)、SEQ ID NO:71(RV DVG B14-TIP-04)、SEQ ID NO:72(RV DVG B14-TIP-05)、SEQ ID NO:73(RV DVG B14-TIP-06)、SEQ ID NO:74(RV DVG B14-TIP-07)、SEQ ID NO:75(RV DVG B14-TIP-08)、SEQID NO:76(RV DVG B14-TIP-09)、SEQ ID NO:77(RV DVG B14-TIP-10)、SEQ ID NO:78(RVDVG B14-TIP-11)、SEQ ID NO:79(RV DVG B14-TIP-12)、SEQ ID NO:80(RV DVG B14-TIP-13)、SEQ ID NO:81(RV DVG B14-TIP-14)、SEQ ID NO:82(RV DVG B14-TIP-15)、SEQ IDNO:83(RV DVG B14-TIP-16)、SEQ ID NO:84(RV DVG B14-TIP-17)、SEQ ID NO:85(RV DVGB14-TIP-18)、SEQ ID NO:86(RV DVG B14-TIP-19)、SEQ ID NO:87(RV DVG B14-TIP-20)、SEQ ID NO:93(YFV DVG-A)、SEQ ID NO:94(YFV DVG-B)、SEQ ID NO:95(YFV DVG-C)、SEQID NO:96(YFV DVG-D)、SEQ ID NO:97(YFV DVG-E)、SEQ ID NO:98(YFV DVG-F)、SEQ IDNO:99(YFV DVG-G)、SEQ ID NO:100(YFV DVG-H)、SEQ ID NO:101(YFV DVG-I)、SEQ ID NO:102(YFV DVG-J)、SEQ ID NO:103(YFV DVG-K)、SEQ ID NO:104(YFV DVG-L),SEQ ID NO:105(WNV DVG-1),SEQ ID NO:106(WNV DVG-2)、SEQ ID NO:107(WNV DVG-3)、SEQ ID NO:108(WNV DVG-4)、SEQ ID NO:109(WNV DVG-5)、SEQ ID NO:110(WNV DVG-6)、SEQ ID NO:111(SARS-CoV-2DVG_1)、SEQ ID NO:112(SARS-CoV-2DVG_2)和SEQ ID NO:113(SARS-CoV-2DVG_3),或与这些序列之一具有至少70%同一性、更优选至少80%同一性、更优选至少90%同一性、更优选至少91%同一性、更优选至少92%同一性、更优选至少93%同一性、更优选至少94%同一性、更优选至少95%同一性、更优选至少96%同一性、更优选至少97%同一性、更优选至少98%同一性、或更优选至少99%同一性的多核苷酸。
50.一种表达载体或质粒,所述表达载体或质粒包含根据权利要求49所述的多核苷酸。
51.一种细胞系,所述细胞系产生根据权利要求12或13所述的DVG。
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