KR20230004655A - 이종이량체 인간 인터류킨-15(hetIL-15)의 약제학적 조성물 및 약제학적 제품 - Google Patents
이종이량체 인간 인터류킨-15(hetIL-15)의 약제학적 조성물 및 약제학적 제품 Download PDFInfo
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US202063013801P | 2020-04-22 | 2020-04-22 | |
| US63/013,801 | 2020-04-22 | ||
| PCT/IB2021/053254 WO2021214658A1 (en) | 2020-04-22 | 2021-04-20 | Pharmaceutical compositions and pharmaceutical products of heterodimeric human interleukin-15 (hetil-15) |
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| KR20230004655A true KR20230004655A (ko) | 2023-01-06 |
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| EP (1) | EP4138782A1 (https=) |
| JP (1) | JP2023523218A (https=) |
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| AU (1) | AU2021260989A1 (https=) |
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| TW (1) | TW202214290A (https=) |
| WO (1) | WO2021214658A1 (https=) |
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| CN117024749A (zh) | 2019-06-28 | 2023-11-10 | 国立大学法人东京大学 | 蛋白质内包高分子胶束 |
| TWI857396B (zh) * | 2021-11-18 | 2024-10-01 | 大陸商山東先聲生物製藥有限公司 | Il-15突變體融合蛋白藥物組合物 |
| IL322075A (en) * | 2023-02-14 | 2025-09-01 | Akron Bioproducts Llc | Pharmaceutical compositions of interleukin for use in vivo |
| CN117883565A (zh) * | 2023-12-25 | 2024-04-16 | 中山大学 | 沙美特罗和pd-1抗体联用在制备治疗黑色素瘤的药物中的应用 |
| WO2025206413A1 (en) * | 2024-03-28 | 2025-10-02 | The University Of Tokyo | Protein-enclosing polymeric complexes |
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| US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
| EP3263581B2 (en) | 2005-05-17 | 2025-07-09 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
| NZ569541A (en) | 2006-01-13 | 2012-05-25 | Us Gov Health & Human Serv | Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells |
| CN101743249B (zh) | 2007-05-11 | 2017-08-08 | 阿尔托生物科学有限公司 | 融合分子与il‑15变异体 |
| CA2711984A1 (en) * | 2008-01-15 | 2009-07-23 | Abbott Gmbh & Co. Kg | Powdered protein compositions and methods of making same |
| CA2727953C (en) | 2008-08-22 | 2017-05-16 | Magna Seating Inc. | Disc recliner with reduced backlash |
| US8915886B2 (en) * | 2009-10-21 | 2014-12-23 | Owen Mumford Limited | Autoinjector |
| US8507222B2 (en) | 2010-09-21 | 2013-08-13 | Altor Bioscience Corporation | Multimeric IL-15 soluble fusion molecules and methods of making and using same |
| EP3292873B1 (en) * | 2013-02-22 | 2019-05-01 | CureVac AG | Combination of vaccination and inhibition of the pd-1 pathway |
| ES2811974T3 (es) * | 2014-07-29 | 2021-03-15 | Novartis Ag | Regímenes de aumento escalonado de la dosis del heterodímero de il-15 e il-15ralfa para tratar afecciones |
| WO2017177063A1 (en) * | 2016-04-06 | 2017-10-12 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of heterodimeric il-15 in adoptive cell transfer |
| WO2019019998A1 (zh) * | 2017-07-25 | 2019-01-31 | 江苏恒瑞医药股份有限公司 | 一种il-15蛋白复合物药物组合物及其用途 |
| EP3810171B1 (en) * | 2018-06-22 | 2025-07-09 | Cugene Inc. | Novel interleukin-15 (1l-15) fusion proteins and uses thereof |
| JP2022530130A (ja) * | 2019-04-26 | 2022-06-27 | ルビウス セラピューティクス， インコーポレイテッド | 除核赤血球細胞を含む緩衝組成物 |
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- 2021-04-20 JP JP2022563971A patent/JP2023523218A/ja active Pending
- 2021-04-20 AU AU2021260989A patent/AU2021260989A1/en active Pending
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- 2021-04-20 US US17/234,914 patent/US20210330747A1/en active Pending
- 2021-04-20 WO PCT/IB2021/053254 patent/WO2021214658A1/en not_active Ceased
- 2021-04-20 IL IL297326A patent/IL297326A/en unknown
- 2021-04-20 MX MX2022013352A patent/MX2022013352A/es unknown
- 2021-04-20 CA CA3178895A patent/CA3178895A1/en active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2023523218A (ja) | 2023-06-02 |
| AU2021260989A1 (en) | 2022-11-17 |
| US20210330747A1 (en) | 2021-10-28 |
| CO2022014867A2 (es) | 2022-10-31 |
| BR112022020973A2 (pt) | 2022-12-06 |
| MX2022013352A (es) | 2022-11-30 |
| CA3178895A1 (en) | 2021-10-28 |
| EP4138782A1 (en) | 2023-03-01 |
| IL297326A (en) | 2022-12-01 |
| AR122428A1 (es) | 2022-09-07 |
| CN115443127A (zh) | 2022-12-06 |
| WO2021214658A1 (en) | 2021-10-28 |
| TW202214290A (zh) | 2022-04-16 |
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