KR20220161414A - 신경 장애 치료를 위한 부프로피온과 덱스트로메토르판 조합의 용도 - Google Patents

신경 장애 치료를 위한 부프로피온과 덱스트로메토르판 조합의 용도 Download PDF

Info

Publication number
KR20220161414A
KR20220161414A KR1020227037493A KR20227037493A KR20220161414A KR 20220161414 A KR20220161414 A KR 20220161414A KR 1020227037493 A KR1020227037493 A KR 1020227037493A KR 20227037493 A KR20227037493 A KR 20227037493A KR 20220161414 A KR20220161414 A KR 20220161414A
Authority
KR
South Korea
Prior art keywords
dextromethorphan
bupropion
week
human
prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020227037493A
Other languages
English (en)
Korean (ko)
Inventor
헤리엇 타부토
Original Assignee
안테씨프 바이오벤쳐스 투 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/894,713 external-priority patent/US10898453B2/en
Application filed by 안테씨프 바이오벤쳐스 투 엘엘씨 filed Critical 안테씨프 바이오벤쳐스 투 엘엘씨
Publication of KR20220161414A publication Critical patent/KR20220161414A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020227037493A 2020-03-30 2021-03-29 신경 장애 치료를 위한 부프로피온과 덱스트로메토르판 조합의 용도 Pending KR20220161414A (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202063002132P 2020-03-30 2020-03-30
US63/002,132 2020-03-30
US202063016178P 2020-04-27 2020-04-27
US63/016,178 2020-04-27
US202063032517P 2020-05-29 2020-05-29
US63/032,517 2020-05-29
US202063032567P 2020-05-30 2020-05-30
US63/032,567 2020-05-30
US16/894,713 US10898453B2 (en) 2013-11-05 2020-06-05 Bupropion as a modulator of drug activity
US16/894,713 2020-06-05
PCT/US2021/024718 WO2021202419A1 (en) 2020-03-30 2021-03-29 Use of bupropion and dextromethorphan combinations for treating neurological disorders

Publications (1)

Publication Number Publication Date
KR20220161414A true KR20220161414A (ko) 2022-12-06

Family

ID=77930161

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227037493A Pending KR20220161414A (ko) 2020-03-30 2021-03-29 신경 장애 치료를 위한 부프로피온과 덱스트로메토르판 조합의 용도

Country Status (6)

Country Link
EP (1) EP4125837A4 (https=)
JP (2) JP7637150B2 (https=)
KR (1) KR20220161414A (https=)
CN (1) CN115697314A (https=)
CA (1) CA3179048A1 (https=)
WO (1) WO2021202419A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11969421B2 (en) 2013-11-05 2024-04-30 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11534414B2 (en) 2013-11-05 2022-12-27 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US12109178B2 (en) 2013-11-05 2024-10-08 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US12194006B2 (en) 2013-11-05 2025-01-14 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11433067B2 (en) 2013-11-05 2022-09-06 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US12569479B2 (en) 2016-05-25 2026-03-10 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US12433884B2 (en) 2020-06-05 2025-10-07 Antecip Bioventures Ii Llc Compounds and combinations thereof for treating neurological and psychiatric conditions
US12472156B2 (en) 2020-06-05 2025-11-18 Antecip Bioventures Ii Llc Compounds and combinations thereof for treating neurological and psychiatric conditions
US20250073188A1 (en) 2020-06-05 2025-03-06 Antecip Bioventures Ii Llc Compounds and combinations thereof for treating neurological and psychiatric conditions
EP4255433A4 (en) 2020-12-01 2024-05-29 Antecip Bioventures II LLC BUPROPION AND DEXTROMETHORPHAN FOR REDUCING THE RISK OF SUICIDE IN DEPRESSED PATIENTS
EP4373480A4 (en) * 2021-07-21 2025-05-28 Antecip Bioventures II LLC TREATMENT OF DEPRESSION
KR20250011185A (ko) * 2022-05-17 2025-01-21 안테씨프 바이오벤쳐스 투 엘엘씨 우울증의 치료
US12156914B2 (en) 2022-06-30 2024-12-03 Axsome Therapeutics, Inc. Pharmaceutical compositions comprising bupropion and cysteine
US12036191B1 (en) 2022-06-30 2024-07-16 Antecip Bioventures Ii Llc Treatment of poor metabolizers of dextromethorphan with a combination of bupropion and dextromethorphan
US11717518B1 (en) * 2022-06-30 2023-08-08 Antecip Bioventures Ii Llc Bupropion dosage forms with reduced food and alcohol dosing effects
US12194036B2 (en) 2022-07-07 2025-01-14 Antecip Bioventures Ii Llc Combination of dextromethorphan and bupropion for treating depression
US11730706B1 (en) 2022-07-07 2023-08-22 Antecip Bioventures Ii Llc Treatment of depression in certain patient populations
US11844797B1 (en) 2023-04-20 2023-12-19 Antecip Bioventures Ii Llc Combination of dextromethorphan and bupropion for treating depression
WO2024118570A1 (en) * 2022-11-28 2024-06-06 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9763932B2 (en) * 2013-11-05 2017-09-19 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US10898453B2 (en) * 2013-11-05 2021-01-26 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11234946B2 (en) * 2013-11-05 2022-02-01 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10080727B2 (en) * 2013-11-05 2018-09-25 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US11273134B2 (en) * 2013-11-05 2022-03-15 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
MY179696A (en) * 2013-11-05 2020-11-11 Antecip Bioventures Ii Llc Compositions and methods comprising bupropion or related compounds and dextromethorphan
US11007189B2 (en) * 2013-11-05 2021-05-18 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity

Also Published As

Publication number Publication date
EP4125837A4 (en) 2024-03-20
JP7637150B2 (ja) 2025-02-27
JP2025032232A (ja) 2025-03-11
EP4125837A1 (en) 2023-02-08
CN115697314A (zh) 2023-02-03
JP2023519965A (ja) 2023-05-15
CA3179048A1 (en) 2021-10-07
WO2021202419A1 (en) 2021-10-07

Similar Documents

Publication Publication Date Title
US12138260B2 (en) Compounds and combinations thereof for treating neurological and psychiatric conditions
US11571417B2 (en) Bupropion as a modulator of drug activity
US11596627B2 (en) Bupropion as a modulator of drug activity
US11517544B2 (en) Bupropion as a modulator of drug activity
US11510918B2 (en) Bupropion as a modulator of drug activity
US11497721B2 (en) Bupropion as a modulator of drug activity
US11617747B2 (en) Bupropion as a modulator of drug activity
US11534414B2 (en) Bupropion as a modulator of drug activity
US11364233B2 (en) Bupropion as a modulator of drug activity
US11357744B2 (en) Bupropion as a modulator of drug activity
US20250032432A1 (en) Bupropion as a modulator of drug activity
US11541021B2 (en) Bupropion as a modulator of drug activity
US20230277478A1 (en) Bupropion as a modulator of drug activity
US11213521B2 (en) Bupropion as a modulator of drug activity
US11185515B2 (en) Bupropion as a modulator of drug activity
US11058648B2 (en) Bupropion as a modulator of drug activity
US11096937B2 (en) Bupropion as a modulator of drug activity
US11229640B2 (en) Combination of dextromethorphan and bupropion for treating depression
US20230131854A1 (en) Bupropion as a modulator of drug activity
US10933034B2 (en) Bupropion as a modulator of drug activity
US10898453B2 (en) Bupropion as a modulator of drug activity
US12109178B2 (en) Bupropion as a modulator of drug activity
US20210023075A1 (en) Bupropion as a modulator of drug activity
KR20220161414A (ko) 신경 장애 치료를 위한 부프로피온과 덱스트로메토르판 조합의 용도
KR20240169131A (ko) 우울증 치료를 위한 덱스트로메토르판과 부프로피온의 조합

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20221026

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20240328

Comment text: Request for Examination of Application