KR20220161404A - 마스킹된 il-2 사이토카인 및 이들의 절단 산물 - Google Patents

마스킹된 il-2 사이토카인 및 이들의 절단 산물 Download PDF

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Publication number
KR20220161404A
KR20220161404A KR1020227037408A KR20227037408A KR20220161404A KR 20220161404 A KR20220161404 A KR 20220161404A KR 1020227037408 A KR1020227037408 A KR 1020227037408A KR 20227037408 A KR20227037408 A KR 20227037408A KR 20220161404 A KR20220161404 A KR 20220161404A
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KR
South Korea
Prior art keywords
cytokine
masked
seq
amino acid
domain
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Pending
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KR1020227037408A
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English (en)
Korean (ko)
Inventor
라파엘 로젠펠드
우구르 에스키오카크
화웨이 치우
파커 존슨
커트 알렌 젠킨스
마갈리 페데르졸리-리베일
디라즈 싱 토마르
레베카 케이 오도넬
Original Assignee
실리오 디벨럽먼트, 인크.
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Application filed by 실리오 디벨럽먼트, 인크. filed Critical 실리오 디벨럽먼트, 인크.
Publication of KR20220161404A publication Critical patent/KR20220161404A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Epidemiology (AREA)
KR1020227037408A 2020-04-01 2021-03-31 마스킹된 il-2 사이토카인 및 이들의 절단 산물 Pending KR20220161404A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063003824P 2020-04-01 2020-04-01
US63/003,824 2020-04-01
US202063118571P 2020-11-25 2020-11-25
US63/118,571 2020-11-25
PCT/US2021/025103 WO2021202675A1 (en) 2020-04-01 2021-03-31 Masked il-2 cytokines and their cleavage products

Publications (1)

Publication Number Publication Date
KR20220161404A true KR20220161404A (ko) 2022-12-06

Family

ID=77928454

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227037408A Pending KR20220161404A (ko) 2020-04-01 2021-03-31 마스킹된 il-2 사이토카인 및 이들의 절단 산물

Country Status (13)

Country Link
US (1) US20230151072A1 (https=)
EP (1) EP4126247A4 (https=)
JP (1) JP7735306B2 (https=)
KR (1) KR20220161404A (https=)
CN (1) CN115942976A (https=)
AU (1) AU2021245922A1 (https=)
BR (1) BR112022019689A2 (https=)
CA (1) CA3172649A1 (https=)
IL (1) IL296915A (https=)
MX (1) MX2022012311A (https=)
PH (1) PH12022552627A1 (https=)
TW (1) TW202204388A (https=)
WO (1) WO2021202675A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019271148B9 (en) 2018-05-14 2025-05-29 Werewolf Therapeutics, Inc. Activatable interleukin-2 polypeptides and methods of use thereof
CA3100005A1 (en) 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
CN120463822A (zh) 2018-09-27 2025-08-12 西里欧发展公司 掩蔽型细胞因子多肽
KR20220023988A (ko) 2019-05-14 2022-03-03 웨어울프 세라퓨틱스, 인크. 분리 모이어티 및 이의 사용 방법
BR112022009110A2 (pt) 2019-11-14 2022-07-26 Werewolf Therapeutics Inc Polipeptídeos de citocina ativáveis e métodos de uso destes
AU2021254283B2 (en) * 2020-04-10 2025-12-11 Cytomx Therapeutics, Inc. Activatable cytokine constructs and related compositions and methods
WO2022115865A2 (en) * 2020-11-25 2022-06-02 Xilio Development, Inc. Tumor-specific cleavable linkers
JP2024511387A (ja) 2021-03-16 2024-03-13 シートムエックス セラピューティクス，インコーポレイテッド マスクした活性化可能サイトカイン構成体ならびに関連する組成物及び方法
WO2023161853A1 (en) 2022-02-23 2023-08-31 Bright Peak Therapeutics Ag Activatable il-18 polypeptides
MX2024010488A (es) * 2022-02-28 2024-09-05 Xilio Dev Inc Citocinas dirigidas y metodos de uso de estas.
WO2023164286A1 (en) * 2022-02-28 2023-08-31 Xilio Development, Inc. Engineered cd122 compositions and methods thereof
KR20250039361A (ko) * 2022-07-15 2025-03-20 실리오 디벨럽먼트, 인크. 담체로서의 조작된 절단성 Fc 도메인 및 이의 사용 방법
CN117917438A (zh) * 2022-10-21 2024-04-23 北京诺诚健华医药科技有限公司 抗体融合蛋白及其制备和应用
WO2024150175A1 (en) 2023-01-11 2024-07-18 Bright Peak Therapeutics Ag Conditionally activated proteins and methods of use
US20240417436A1 (en) 2023-01-11 2024-12-19 Bright Peak Therapeutics Ag Conditionally activated immunocytokines and methods of use
TW202517789A (zh) * 2023-07-04 2025-05-01 香港商禮邦醫藥（香港）有限公司 Ｋｌｋ１融合蛋白質的製備方法
WO2025041101A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Activatable il-18 immunocytokines and uses thereof
WO2025049948A1 (en) * 2023-08-30 2025-03-06 Xilio Development, Inc. Masked il-2 cytokines and methods of use thereof
WO2025162454A1 (zh) * 2024-02-02 2025-08-07 北京昌平实验室 双特异性抗体和细胞因子融合蛋白及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
EP2553101A4 (en) * 2010-04-02 2013-09-04 Univ Rochester PROTEASE-ACTIVATED CYTOKINES
HUE029139T2 (hu) * 2011-02-10 2017-02-28 Roche Glycart Ag Mutáns interleukin-2 polipeptidek
EP2882775B1 (en) * 2012-08-09 2018-02-14 Roche Glycart AG Asgpr antibodies and uses thereof
US9605084B2 (en) * 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
CN108218993B (zh) * 2018-01-05 2020-11-17 阿思科力(苏州)生物科技有限公司 一种以robo1为靶点的双特异性抗体及其制备和应用
WO2019173832A2 (en) * 2018-03-09 2019-09-12 AskGene Pharma, Inc. Novel cytokine prodrugs
AU2019271148B9 (en) * 2018-05-14 2025-05-29 Werewolf Therapeutics, Inc. Activatable interleukin-2 polypeptides and methods of use thereof
US12459980B2 (en) * 2018-07-25 2025-11-04 AskGene Pharma, Inc. IL-21 prodrugs and methods of use thereof
CN112867503A (zh) * 2018-08-24 2021-05-28 希望之城 掩蔽的细胞因子缀合物
CN120463822A (zh) * 2018-09-27 2025-08-12 西里欧发展公司 掩蔽型细胞因子多肽
JP2022533254A (ja) 2019-05-24 2022-07-21 プロヴィヴァ セラピューティクス （ホン コン） リミテッド Ｉｌ－２組成物およびその使用方法

Also Published As

Publication number Publication date
MX2022012311A (es) 2023-01-05
AU2021245922A1 (en) 2022-10-13
JP7735306B2 (ja) 2025-09-08
EP4126247A1 (en) 2023-02-08
PH12022552627A1 (en) 2023-01-04
US20230151072A1 (en) 2023-05-18
BR112022019689A2 (pt) 2022-12-20
EP4126247A4 (en) 2024-04-24
CN115942976A (zh) 2023-04-07
WO2021202675A1 (en) 2021-10-07
CA3172649A1 (en) 2021-10-07
TW202204388A (zh) 2022-02-01
JP2023520517A (ja) 2023-05-17
IL296915A (en) 2022-12-01

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