KR20220152554A - 코로나바이러스-유도된 급성 호흡 곤란 증후군의 치료 및/또는 예방을 위해 masp-2를 억제하는 방법 - Google Patents
코로나바이러스-유도된 급성 호흡 곤란 증후군의 치료 및/또는 예방을 위해 masp-2를 억제하는 방법 Download PDFInfo
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- KR20220152554A KR20220152554A KR1020227034690A KR20227034690A KR20220152554A KR 20220152554 A KR20220152554 A KR 20220152554A KR 1020227034690 A KR1020227034690 A KR 1020227034690A KR 20227034690 A KR20227034690 A KR 20227034690A KR 20220152554 A KR20220152554 A KR 20220152554A
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A—HUMAN NECESSITIES
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062986566P | 2020-03-06 | 2020-03-06 | |
US62/986,566 | 2020-03-06 | ||
US202063008540P | 2020-04-10 | 2020-04-10 | |
US63/008,540 | 2020-04-10 | ||
US202063015299P | 2020-04-24 | 2020-04-24 | |
US63/015,299 | 2020-04-24 | ||
US202063054298P | 2020-07-21 | 2020-07-21 | |
US63/054,298 | 2020-07-21 | ||
US202063062843P | 2020-08-07 | 2020-08-07 | |
US63/062,843 | 2020-08-07 | ||
US202063104229P | 2020-10-22 | 2020-10-22 | |
US63/104,229 | 2020-10-22 | ||
US202063105637P | 2020-10-26 | 2020-10-26 | |
US63/105,637 | 2020-10-26 | ||
US202163140591P | 2021-01-22 | 2021-01-22 | |
US63/140,591 | 2021-01-22 | ||
PCT/US2021/021217 WO2021178902A1 (fr) | 2020-03-06 | 2021-03-05 | Procédés d'inhibition de masp -2 pour le traitement et/ou la prévention du syndrome de détresse respiratoire aiguë induite par le coronavirus |
Publications (1)
Publication Number | Publication Date |
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KR20220152554A true KR20220152554A (ko) | 2022-11-16 |
Family
ID=77614472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020227034690A KR20220152554A (ko) | 2020-03-06 | 2021-03-05 | 코로나바이러스-유도된 급성 호흡 곤란 증후군의 치료 및/또는 예방을 위해 masp-2를 억제하는 방법 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20210292436A1 (fr) |
EP (1) | EP4114522A4 (fr) |
JP (1) | JP2023516727A (fr) |
KR (1) | KR20220152554A (fr) |
CN (1) | CN115335120A (fr) |
AU (1) | AU2021231892A1 (fr) |
BR (1) | BR112022016991A2 (fr) |
CA (1) | CA3169034A1 (fr) |
IL (1) | IL296240A (fr) |
MX (1) | MX2022010449A (fr) |
TW (1) | TW202319069A (fr) |
WO (1) | WO2021178902A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112237630A (zh) * | 2020-02-21 | 2021-01-19 | 中国人民解放军军事科学院军事医学研究院 | 针对masp-2、冠状病毒n蛋白或其结合的物质在制备冠状病毒所致疾病药物中的应用 |
CN112023045A (zh) * | 2020-03-31 | 2020-12-04 | 中国人民解放军军事科学院军事医学研究院 | 抑制masp-2及其下游补体活化效应的物质在制备冠状病毒所致疾病药物中的应用 |
WO2023174039A1 (fr) * | 2022-03-18 | 2023-09-21 | Inmagene Biopharmaceuticals (Hangzhou) Co., Ltd. | Anticorps ciblant masp-2 et leurs utilisations |
WO2024081269A1 (fr) * | 2022-10-10 | 2024-04-18 | Dixit Rohan | Combinaisons thérapeutiques et méthodes de traitement de covid longue |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2446900T (lt) * | 2004-06-10 | 2017-07-25 | Omeros Corporation | Ligų, susijusių su nuo masp-2 priklausomu komplemento aktyvavimu, gydymo būdai |
KR101641057B1 (ko) * | 2011-05-04 | 2016-07-20 | 오메로스 코포레이션 | Masp-2 의존적 보체 활성화를 억제하는 조성물 |
CN109908352A (zh) * | 2012-06-18 | 2019-06-21 | 奥默罗斯公司 | 抑制masp-1和/或masp-2和/或masp-3的组合物和方法 |
EP2920592A4 (fr) * | 2012-11-13 | 2016-07-06 | Biogenius Llc | Compositions et procédés de traitement de maladies inflammatoires d'origine infectieuse et non infectieuse |
CN117964684A (zh) * | 2018-05-29 | 2024-05-03 | 奥默罗斯公司 | Masp-2抑制剂和使用方法 |
SG11202012627UA (en) * | 2018-06-22 | 2021-01-28 | Omeros Corp | Compositions and methods of inhibiting masp-2 for the treatment of various thrombotic diseases and disorders |
CN112237630A (zh) * | 2020-02-21 | 2021-01-19 | 中国人民解放军军事科学院军事医学研究院 | 针对masp-2、冠状病毒n蛋白或其结合的物质在制备冠状病毒所致疾病药物中的应用 |
CN112023045A (zh) * | 2020-03-31 | 2020-12-04 | 中国人民解放军军事科学院军事医学研究院 | 抑制masp-2及其下游补体活化效应的物质在制备冠状病毒所致疾病药物中的应用 |
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2021
- 2021-03-03 TW TW112103343A patent/TW202319069A/zh unknown
- 2021-03-05 MX MX2022010449A patent/MX2022010449A/es unknown
- 2021-03-05 KR KR1020227034690A patent/KR20220152554A/ko active Search and Examination
- 2021-03-05 CA CA3169034A patent/CA3169034A1/fr active Pending
- 2021-03-05 JP JP2022553016A patent/JP2023516727A/ja active Pending
- 2021-03-05 IL IL296240A patent/IL296240A/en unknown
- 2021-03-05 WO PCT/US2021/021217 patent/WO2021178902A1/fr active Application Filing
- 2021-03-05 CN CN202180019367.6A patent/CN115335120A/zh active Pending
- 2021-03-05 US US17/194,054 patent/US20210292436A1/en active Pending
- 2021-03-05 EP EP21764370.9A patent/EP4114522A4/fr active Pending
- 2021-03-05 BR BR112022016991A patent/BR112022016991A2/pt unknown
- 2021-03-05 AU AU2021231892A patent/AU2021231892A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4114522A4 (fr) | 2024-05-01 |
BR112022016991A2 (pt) | 2022-12-06 |
WO2021178902A1 (fr) | 2021-09-10 |
EP4114522A1 (fr) | 2023-01-11 |
TW202146047A (zh) | 2021-12-16 |
IL296240A (en) | 2022-11-01 |
AU2021231892A1 (en) | 2022-10-20 |
TW202319069A (zh) | 2023-05-16 |
US20210292436A1 (en) | 2021-09-23 |
CA3169034A1 (fr) | 2021-09-10 |
JP2023516727A (ja) | 2023-04-20 |
MX2022010449A (es) | 2022-11-16 |
CN115335120A (zh) | 2022-11-11 |
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