KR20220148823A - Poxvirus-based vectors produced by natural or synthetic DNA and uses thereof - Google Patents
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Abstract
천연적으로 유래된, 화학적으로 합성된 DNA 단편, 또는 천연적으로 유래된 및 화학적으로 합성된 DNA 단편의 조합으로부터 폭스바이러스-기반 벡터 또는 재조합 폭스바이러스-기반 벡터를 생산하는 방법이 개시된다. 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열 또는 다른 이종성 유전자 서열이 하나 이상의 DNA 단편에서 하나 이상의 폭스바이러스 삽입 부위에 삽입된다. 방법은 폭스바이러스 또는 재조합 폭스바이러스가 숙주 세포에서 재구성되고, 재구성된 폭스바이러스 또는 재조합 폭스바이러스가 목적하는 폭스바이러스의 게놈을 포함하도록 숙주 세포를 하나 이상의 원형 또는 선형 DNA 단편으로 형질감염시키는 것을 포함한다. 또한 기술에 의해 생산된 폭스바이러스 또는 재조합 폭스바이러스 및 그의 용도가 개시된다.Disclosed is a method for producing a poxvirus-based vector or a recombinant poxvirus-based vector from a naturally derived, chemically synthesized DNA fragment, or a combination of naturally derived and chemically synthesized DNA fragments. One or more DNA sequences or other heterologous gene sequences encoding one or more antigens, subunits or fragments thereof are inserted at one or more poxvirus insertion sites in the one or more DNA fragments. The method comprises reconstituting a poxvirus or recombinant poxvirus in the host cell and transfecting the host cell with one or more circular or linear DNA fragments such that the reconstituted poxvirus or recombinant poxvirus comprises the genome of the desired poxvirus. . Also disclosed are poxviruses or recombinant poxviruses produced by the technology and uses thereof.
Description
우선권 주장claim priority
본 출원은 2020년 2월 3일에 출원된 미국 특허 가출원 번호 62/969,628, 및 2020년 11월 13일에 출원된 미국 특허 가출원 번호 63/113,803을 우선권 주장하며, 그 내용은 그 전문이 본원에 참조로서 포함된다.This application claims priority to U.S. Provisional Patent Application No. 62/969,628, filed on February 3, 2020, and U.S. Provisional Patent Application No. 63/113,803, filed on November 13, 2020, the contents of which are herein incorporated by reference in their entirety. incorporated by reference.
서열 목록sequence list
본 출원은 ASCII 포맷으로 전자 제출되었고 그 전문이 본원에 참조로서 포함된 서열 목록을 함유한다. 2021년 2월 2일에 생성된 상기 ASCII 사본은 8200WO00_SequenceListing.txt로 명명되고 652 킬로바이트 크기이다.This application has been filed electronically in ASCII format and contains a Sequence Listing, which is incorporated herein by reference in its entirety. Said ASCII copy, created on February 2, 2021, is named 8200WO00_SequenceListing.txt and is 652 kilobytes in size.
폭스바이러스(poxvirus)는 DNA 전사 및 복제를 위한 그 자체의 효소를 코딩함으로써 감염된 세포의 세포질에서 완전히 복제하는 큰 이중 가닥, 외피형 DNA 바이러스이다20,27. 의학 역사에서 가장 큰 성취 중 하나는 복제-적격, 약독화된 백시니아 바이러스(Vaccinia virus) 백신 균주로의 집단 백신접종에 의한 두창의 원인 인자 (바리올라 바이러스(Variola virus))의 박멸이었다. 백시니아 바이러스는 폭스바이러스 복제를 연구하기 위한 원형 구성원으로서 사용되고 추가로 재조합 백신 및 종양용해 작용제를 생성하기 위해 개발되어 왔다.Poxviruses are large double-stranded, enveloped DNA viruses that fully replicate in the cytoplasm of infected cells by encoding their own enzymes for DNA transcription and replication 20,27 . One of the greatest achievements in medical history has been the eradication of the causative agent of smallpox (Variola virus) by herd vaccination with a replication-competent, attenuated Vaccinia virus vaccine strain. Vaccinia virus has been used as a prototype member to study poxvirus replication and has been further developed to generate recombinant vaccines and oncolytic agents.
변형된 백시니아 앙카라 (MVA: Modified Vaccinia Ankara)는 닭 배아 섬유모세포 (CEF) 상 570회 계대에 의해 그의 모 균주 융모요막 백시니아 앙카라 (CVA: Chorioallantois Vaccinia Ankara)로부터 유래된 매우 약독화된 오르토폭스바이러스(orthopoxvirus)이다1. 약독화 과정의 결과로서 MVA는 6개의 주요 게놈 결실 (Del1-6) 뿐만 아니라 다수의 보다 짧은 결실, 삽입, 및 점 돌연변이를 획득하였고, 이는 유전자 단편화, 절단, 짧은 내부 결실, 및 아미노산 치환을 일으킨다2. 이들 돌연변이 모두가 MVA의 매우 약독화된 표현형에 기여할 가능성이 있지만, MVA 조립 결핍과 연관되는 정확한 유전자 결정자는 여전히 불분명하다2,3. MVA는 숙주 세포 향성을 심각하게 제한하였고, 이는 조류 세포, 예를 들어 CEF 및 아기 햄스터 신장 (BHK) 세포에서만 생산적인 조립을 허용하는 반면에, 인간 및 대부분의 다른 포유류 세포에서는, MVA 조립이 바이러스 조립의 늦은 차단으로 인해 중단된다4,5. 비병원성이고 매우 약독화되었지만, MVA는 다양한 동물 모델 및 인간에서 입증된 바와 같이 우수한 면역원성을 유지한다6,7. 두창 박멸 캠페인의 후기에서, MVA는 독일에서 120,000명 초과의 개체에서 복제 적격 백시니아-기반 백신을 위한 프라이밍 벡터로서 사용되었고 유해 사례는 보고되지 않았다8. 지난 수십 년 동안, MVA는 독립형 두창 백신으로서 개발되어 왔고 현재 미국 (US) 정부에 의해 두창 발병 시 예방 대책으로서의 기존 백시니아-기반 백신 스톡을 대체하기 위한 보다 안전한 대안으로서 추구된다9-11. FDA는 두창 및 원숭이 두창 둘 다를 예방하기 위해 2019년 9월 24일에 상표명 진네오스(Jynneos) (바바리안 노르딕(Bavarian Nordic)) 하에 MVA를 승인하였다. 이전에, 상표명 임바뮨(Imvamune)을 사용하는 동일한 MVA 백신이 유럽에서 두창 백신으로서 승인되었다.Modified Vaccinia Ankara (MVA) is a highly attenuated orthopox derived from its parent strain Chorioallantois Vaccinia Ankara (CVA) by passage 570 on chicken embryonic fibroblasts (CEF). It is an orthopoxvirus 1 . As a result of the attenuation process, MVA acquired six major genomic deletions (Del1-6) as well as a number of shorter deletions, insertions, and point mutations, resulting in gene fragmentation, truncations, short internal deletions, and amino acid substitutions. 2 . Although all of these mutations likely contribute to the highly attenuated phenotype of MVA, the precise genetic determinants associated with MVA assembly deficiency remain unclear 2,3 . MVA severely limited host cell tropism, which allowed for productive assembly only in avian cells, e.g., CEF and baby hamster kidney (BHK) cells, whereas in humans and most other mammalian cells, MVA assembly is highly resistant to viruses. 4,5 It is interrupted due to late blockage of assembly. Although non-pathogenic and highly attenuated, MVA retains good immunogenicity as demonstrated in various animal models and humans 6,7 . In the later stages of the smallpox eradication campaign, MVA was used as a priming vector for a replication competent vaccinia-based vaccine in more than 120,000 individuals in Germany and no adverse events were reported 8 . Over the past few decades, MVA has been developed as a standalone smallpox vaccine and is currently pursued by the US government as a safer alternative to replace the existing vaccinia-based vaccine stock as a preventive measure in case of smallpox outbreaks 9-11 . The FDA approved MVA under the trade name Jynneos (Bavarian Nordic) on September 24, 2019 to prevent both smallpox and monkey smallpox. Previously, the same MVA vaccine using the trade name Imvamune was approved as a smallpox vaccine in Europe.
현재 사용되는 모든 MVA 벡터 또는 그의 유도체는 학술, 상업, 또는 정부 기관에 의해 허가되거나 또는 소유되며, 이는 MVA-기반 백신 벡터를 개발하기 위한 그의 사용을 크게 제한한다. 따라서, 다양한 연구, 예방적, 및 치료적 사용을 위한 대안적인 MVA 벡터를 개발할 필요가 있다. 또한, 병원체 대비 및 질환 예방을 위한 재조합 폭스바이러스 벡터의 개발을 가속화하기 위해 신규 기술이 시급히 필요하다.All MVA vectors or derivatives thereof currently used are licensed or owned by academic, commercial, or government agencies, which greatly limits their use to develop MVA-based vaccine vectors. Therefore, there is a need to develop alternative MVA vectors for various research, prophylactic, and therapeutic uses. In addition, new technologies are urgently needed to accelerate the development of recombinant poxvirus vectors for pathogen preparation and disease prevention.
한 측면에서, 본 개시내용은 폭스바이러스 벡터 또는 재조합 폭스바이러스 벡터를 생산하는 방법에 관한 것이다. 방법은 하나 이상의 DNA 단편을 숙주 세포로 형질감염시키며, 여기서 하나 이상의 DNA 단편은 폭스바이러스가 숙주 세포에서 재구성되도록 목적하는 폭스바이러스의 전체 게놈 DNA 서열을 포함하는 것인 단계를 수반한다. 특정 실시양태에서, 2개 이상의 DNA 단편이 숙주 세포로 공동-형질감염되며, 각각의 DNA 단편은 2개 이상의 DNA 단편이 숙주 세포에서 재구성될 때 상동성 재조합에 의해 순차적으로 조립되어 폭스바이러스 게놈의 전장 서열을 포함하도록 폭스바이러스 게놈의 부분적인 서열을 포함한다. 특정 실시양태에서, 방법은 하나 이상의 DNA 단편의 형질감염 전에, 그 동안, 또는 그 후에 숙주 세포를 헬퍼 바이러스로 감염시켜 하나 이상의 DNA 단편의 전사를 개시하는 것을 추가로 수반한다. 특정 실시양태에서, 헬퍼 바이러스는 계두 바이러스 (FPV: Fowl pox virus)), 양 섬유종 바이러스, 백시니아 바이러스, 또는 우두 바이러스이다. 특정 실시양태에서, 하나 이상의 DNA 단편은 형질감염 전에 원형화되거나 또는 원형 형태로 숙주 세포로 형질감염된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 플라스미드 또는 박테리아 인공 염색체 (BAC) 벡터로 클로닝된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 공동-형질감염 전에 선형화되거나 또는 선형화된 형태로 숙주 세포로 형질감염된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 천연적으로 유래되거나, 화학적으로 합성되거나, 또는 천연적으로 유래된 및 화학적으로 합성된 DNA 단편의 조합이다. 특정 실시양태에서, 폭스바이러스 게놈 서열은 변형된 백시니아 앙카라 (MVA) 수탁 번호 #U94848 또는 #AY603355의 서열을 포함한다. 특정 실시양태에서, 폭스바이러스 게놈 서열은 백시니아 바이러스 게놈의 서열을 포함한다. 특정 실시양태에서, 2개의 인접한 DNA 단편은 상동성 재조합을 용이하게 하는 중첩된 서열을 갖는다. 특정 실시양태에서, 중첩된 서열은 약 100 bp 내지 약 5000 bp 길이이다. 특정 실시양태에서, 하나 이상의 DNA 단편은 역전된 말단 반복부 (ITR) 영역을 추가로 포함한다. 특정 실시양태에서, 하나 이상의 DNA 단편은 폭스바이러스 말단 헤어핀 루프 (HL) 서열, 폭스바이러스 게놈 분해 (CR) 서열, 또는 둘 다를 추가로 포함하며, 여기서 HL 또는 CR 서열은 센스 또는 안티센스 배향으로 단일 가닥 또는 이중 가닥 DNA 서열로서 DNA 단편의 1개 또는 양쪽 단부에 부가된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 하나 이상의 HL 서열 및 하나 이상의 CR 서열을 추가로 포함한다. 특정 실시양태에서, 각각의 HL 서열은 HL 서열의 양쪽 단부에서 2개의 CR 서열에 의해 플랭킹된다. 특정 실시양태에서, 오직 하나 이상의 DNA 단편의 하위세트만이 HL 또는 CR 서열을 포함한다. 특정 실시양태에서, 하나 이상의 DNA 단편은 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열 또는 다른 이종성 DNA 서열을 추가로 포함한다. 특정 실시양태에서, 2개 이상의 DNA 단편은 동일한 항원, 그의 서브유닛 또는 단편의 DNA 서열 또는 동일한 이종성 DNA 서열을 포함한다. 특정 실시양태에서, 2개 이상의 DNA 단편은 상이한 항원, 그의 서브유닛 또는 단편의 DNA 서열 또는 다른 이종성 DNA 서열을 포함한다. 특정 실시양태에서, 항원, 그의 서브유닛 또는 단편의 DNA 서열 또는 다른 이종성 DNA 서열은 숙주 세포에서의 발현에 코돈 최적화된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 항원, 그의 서브유닛 또는 단편의 DNA 서열 또는 다른 이종성 DNA 서열의 바이러스 프로모터 상류, 항원, 그의 서브유닛 또는 단편의 DNA 서열 또는 다른 이종성 DNA 서열 전사 종결 신호 하류, 또는 둘 다를 추가로 포함한다. 특정 실시양태에서, 항원, 그의 서브유닛 또는 단편을 코딩하는 DNA 서열 또는 다른 이종성 DNA 서열은 하나 이상의 폭스바이러스 삽입 부위 예컨대 유전자간 영역, 비필수 유전자 및 영역, 및 결실 부위에 삽입된다.In one aspect, the present disclosure relates to a poxvirus vector or a method of producing a recombinant poxvirus vector. The method involves transfecting one or more DNA fragments into a host cell, wherein the one or more DNA fragments comprise the entire genomic DNA sequence of a poxvirus of interest such that the poxvirus is reconstituted in the host cell. In certain embodiments, two or more DNA fragments are co-transfected into a host cell, each DNA fragment being sequentially assembled by homologous recombination when the two or more DNA fragments are reconstituted in the host cell to form a fragment of the poxvirus genome. contains a partial sequence of the poxvirus genome to include the full-length sequence. In certain embodiments, the method further involves infecting a host cell with a helper virus prior to, during, or after transfection of the one or more DNA fragments to initiate transcription of the one or more DNA fragments. In certain embodiments, the helper virus is Fowl pox virus (FPV), sheep fibroma virus, vaccinia virus, or vaccinia virus. In certain embodiments, one or more DNA fragments are circularized or transfected into a host cell in circular form prior to transfection. In certain embodiments, one or more DNA fragments are cloned into a plasmid or bacterial artificial chromosome (BAC) vector. In certain embodiments, one or more DNA fragments are linearized or transfected into a host cell in a linearized form prior to co-transfection. In certain embodiments, the one or more DNA fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments. In certain embodiments, the poxvirus genomic sequence comprises the sequence of modified vaccinia ankara (MVA) accession number #U94848 or #AY603355. In certain embodiments, the poxvirus genomic sequence comprises a sequence of a vaccinia virus genome. In certain embodiments, two adjacent DNA fragments have overlapping sequences that facilitate homologous recombination. In certain embodiments, the overlapping sequence is from about 100 bp to about 5000 bp in length. In certain embodiments, the one or more DNA fragments further comprise an inverted terminal repeat (ITR) region. In certain embodiments, the one or more DNA fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genomic degradation (CR) sequence, or both, wherein the HL or CR sequence is single-stranded in a sense or antisense orientation. or added to one or both ends of the DNA fragment as a double-stranded DNA sequence. In certain embodiments, the one or more DNA fragments further comprise one or more HL sequences and one or more CR sequences. In certain embodiments, each HL sequence is flanked by two CR sequences at both ends of the HL sequence. In certain embodiments, only a subset of one or more DNA fragments comprises an HL or CR sequence. In certain embodiments, the one or more DNA fragments further comprise one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof. In certain embodiments, the two or more DNA fragments comprise DNA sequences of the same antigen, subunits or fragments thereof, or identical heterologous DNA sequences. In certain embodiments, the two or more DNA fragments comprise DNA sequences of different antigens, subunits or fragments thereof, or other heterologous DNA sequences. In certain embodiments, the DNA sequence or other heterologous DNA sequence of the antigen, subunit or fragment thereof, is codon optimized for expression in a host cell. In certain embodiments, the one or more DNA fragments comprise a viral promoter upstream of the antigen, a DNA sequence of a subunit or fragment thereof or other heterologous DNA sequence, a DNA sequence of the antigen, a subunit or fragment thereof, or other heterologous DNA sequence downstream of a transcription termination signal; or both. In certain embodiments, a DNA sequence or other heterologous DNA sequence encoding an antigen, subunit or fragment thereof, is inserted at one or more poxvirus insertion sites such as intergenic regions, non-essential genes and regions, and deletion sites.
또 다른 측면에서, (i) 목적하는 폭스바이러스의 전체 게놈을 포함하는 단일 DNA 단편, 또는 2개 이상의 DNA 단편이, 공동-형질감염 시 숙주 세포로 전달될 때, 순차적으로 조립되어 폭스바이러스 게놈의 전장 서열을 포함하고 폭스바이러스의 재구성을 가능하게 하도록 목적하는 폭스바이러스의 게놈의 부분적인 서열을 각각 포함하는 2개 이상의 DNA 단편, 및 (ii) 폭스바이러스의 하나 이상의 삽입 부위에 삽입된 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열 또는 다른 이종성 DNA 서열로서, 여기서 항원 또는 그의 서브유닛 또는 다른 이종성 DNA 서열은 하나 이상의 폭스바이러스 DNA 단편의 형질감염 및 폭스바이러스의 재구성 시 숙주 세포에서 발현되는 것인 DNA 서열을 포함하는 발현 시스템이 본원에 개시된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 형질감염 전에 원형화되거나 또는 원형 형태로 숙주 세포로 형질감염된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 플라스미드 또는 BAC 벡터로 클로닝된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 형질감염 전에 선형화되거나 또는 선형화된 형태로 숙주 세포로 형질감염된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 천연적으로 유래되거나, 화학적으로 합성되거나, 또는 천연적으로 유래된 및 화학적으로 합성된 DNA 단편의 조합이다. 특정 실시양태에서, 폭스바이러스의 게놈 서열은 MVA 수탁 번호 #U94848 또는 #AY603355의 서열을 포함한다. 특정 실시양태에서, 2개의 인접한 DNA 단편은 상동성 재조합을 용이하게 하는 중첩된 서열을 갖는다. 특정 실시양태에서, 중첩된 서열은 약 100 bp 내지 약 5000 bp 길이이다. 특정 실시양태에서, 하나 이상의 DNA 단편은 역전된 말단 반복부 (ITR) 영역을 추가로 포함한다. 특정 실시양태에서, 하나 이상의 DNA 단편은 폭스바이러스 말단 헤어핀 루프 (HL) 서열, 폭스바이러스 게놈 분해 (CR) 서열, 또는 둘 다를 추가로 포함하며, 여기서 HL 또는 CR 서열은 센스 또는 안티센스 배향으로 단일 가닥 또는 이중 가닥 DNA 서열로서 DNA 단편의 1개 또는 양쪽 단부에 부가된다. 특정 실시양태에서, 하나 이상의 DNA 단편은 하나 이상의 HL 서열 및 하나 이상의 CR 서열을 추가로 포함한다. 특정 실시양태에서, 각각의 HL 서열은 HL 서열의 양쪽 단부에서 2개의 CR 서열에 의해 플랭킹된다. 특정 실시양태에서, 오직 하나 이상의 DNA 단편의 하위세트만이 HL 또는 CR 서열을 포함한다. 특정 실시양태에서, 하나 이상의 DNA 단편은 항원, 그의 서브유닛 또는 단편을 코딩하는 DNA 서열 또는 다른 이종성 DNA 서열의 바이러스 프로모터 상류, 항원, 그의 서브유닛 또는 단편을 코딩하는 DNA 서열 또는 다른 이종성 DNA 서열의 전사 종결 신호 하류, 또는 둘 다를 추가로 포함한다. 특정 실시양태에서, 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 DNA 서열 또는 다른 이종성 DNA 서열은 하나 이상의 폭스바이러스 삽입 부위에 삽입된다.In another aspect, (i) a single DNA fragment, or two or more DNA fragments, comprising the entire genome of a poxvirus of interest, when delivered to a host cell upon co-transfection, assembles sequentially to form the poxvirus genome two or more DNA fragments comprising the full-length sequence and each comprising a partial sequence of the genome of the desired poxvirus to enable reconstitution of the poxvirus, and (ii) one or more antigens inserted at one or more insertion sites of the poxvirus , one or more DNA sequences or other heterologous DNA sequences encoding subunits or fragments thereof, wherein the antigen or subunits or other heterologous DNA sequences are present in a host cell upon transfection of the one or more poxvirus DNA fragments and reconstitution of the poxviruses. Disclosed herein is an expression system comprising a DNA sequence that is to be expressed. In certain embodiments, one or more DNA fragments are circularized or transfected into a host cell in circular form prior to transfection. In certain embodiments, one or more DNA fragments are cloned into a plasmid or BAC vector. In certain embodiments, one or more DNA fragments are linearized or transfected into a host cell in a linearized form prior to transfection. In certain embodiments, the one or more DNA fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments. In certain embodiments, the genomic sequence of the poxvirus comprises the sequence of MVA accession number #U94848 or #AY603355. In certain embodiments, two adjacent DNA fragments have overlapping sequences that facilitate homologous recombination. In certain embodiments, the overlapping sequence is from about 100 bp to about 5000 bp in length. In certain embodiments, the one or more DNA fragments further comprise an inverted terminal repeat (ITR) region. In certain embodiments, the one or more DNA fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genomic degradation (CR) sequence, or both, wherein the HL or CR sequence is single-stranded in a sense or antisense orientation. or added to one or both ends of the DNA fragment as a double-stranded DNA sequence. In certain embodiments, the one or more DNA fragments further comprise one or more HL sequences and one or more CR sequences. In certain embodiments, each HL sequence is flanked by two CR sequences at both ends of the HL sequence. In certain embodiments, only a subset of one or more DNA fragments comprises an HL or CR sequence. In certain embodiments, the one or more DNA fragments comprise a DNA sequence encoding an antigen, a subunit or fragment thereof, or another heterologous DNA sequence upstream of a viral promoter, a DNA sequence encoding an antigen, a subunit or fragment thereof, or other heterologous DNA sequence. downstream of a transcription termination signal, or both. In certain embodiments, a DNA sequence or other heterologous DNA sequence encoding one or more antigens, subunits or fragments thereof is inserted at one or more poxvirus insertion sites.
또 다른 측면에서, (i) 목적하는 폭스바이러스의 전체 게놈을 포함하는 단일 DNA 단편, 또는 2개 이상의 DNA 단편이, 공동-형질감염 시 숙주 세포로 전달될 때, 순차적으로 조립되어 폭스바이러스 게놈의 전장 서열을 포함하고 폭스바이러스의 재구성을 가능하게 하도록 목적하는 폭스바이러스의 게놈의 부분적인 서열을 각각 포함하는 2개 이상의 DNA 단편, 및 (ii) 폭스바이러스의 하나 이상의 삽입 부위에 삽입된 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열 또는 다른 이종성 DNA 서열로서, 여기서 항원, 그의 서브유닛 또는 단편 또는 다른 이종성 DNA 서열은 하나 이상의 DNA 단편의 형질감염 및 폭스바이러스의 재구성 시 숙주 세포에서 발현되는 것인 DNA 서열을 포함하는, 암 또는 감염성 질환을 예방하거나 또는 치료하기 위한 백신 조성물이 본원에 개시된다. 특정 실시양태에서, 항원, 그의 서브유닛 또는 단편 또는 다른 이종성 DNA 서열은 하나 이상의 폭스바이러스 삽입 부위에 삽입된다. 특정 실시양태에서, 백신 조성물은 제약상 허용되는 담체, 아주반트, 첨가제 또는 이들의 조합을 추가로 포함한다.In another aspect, (i) a single DNA fragment, or two or more DNA fragments, comprising the entire genome of a poxvirus of interest, when delivered to a host cell upon co-transfection, assembles sequentially to form the poxvirus genome two or more DNA fragments comprising the full-length sequence and each comprising a partial sequence of the genome of the desired poxvirus to enable reconstitution of the poxvirus, and (ii) one or more antigens inserted at one or more insertion sites of the poxvirus , one or more DNA sequences or other heterologous DNA sequences encoding subunits or fragments thereof, wherein the antigen, subunits or fragments thereof or other heterologous DNA sequences are present in a host cell upon transfection of the one or more DNA fragments and reconstitution of the poxvirus. Disclosed herein is a vaccine composition for preventing or treating cancer or an infectious disease comprising a DNA sequence that is expressed. In certain embodiments, the antigen, subunit or fragment thereof or other heterologous DNA sequence is inserted at one or more poxvirus insertion sites. In certain embodiments, the vaccine composition further comprises a pharmaceutically acceptable carrier, adjuvant, additive, or combination thereof.
또 다른 측면에서, 대상체에게 예방 또는 치료 유효량의 백신 조성물을 투여하는 것을 포함하는, 대상체에서 암 또는 바이러스 감염을 예방하거나 또는 치료하는 방법이 본원에 개시되며, 여기서 백신은 (i) 목적하는 폭스바이러스의 전체 게놈을 포함하는 단일 DNA 단편, 또는 2개 이상의 DNA 단편이, 공동-형질감염 시 숙주 세포로 전달될 때, 순차적으로 조립되어 폭스바이러스 게놈의 전장 서열을 포함하고 폭스바이러스의 재구성을 가능하게 하도록 목적하는 폭스바이러스의 게놈의 부분적인 서열을 각각 포함하는 2개 이상의 DNA 단편, 및 (ii) 폭스바이러스의 하나 이상의 삽입 부위에 삽입된 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열 또는 다른 이종성 DNA 서열로서, 여기서 항원, 그의 서브유닛 또는 단편 또는 다른 이종성 DNA 서열은 하나 이상의 DNA 단편의 형질감염 및 폭스바이러스의 재구성 시 숙주 세포에서 발현되는 것인 DNA 서열을 포함한다. 특정 실시양태에서, 항원, 그의 서브유닛 또는 단편 또는 다른 이종성 DNA 서열은 하나 이상의 폭스바이러스 삽입 부위에 삽입된다.In another aspect, disclosed herein is a method of preventing or treating a cancer or viral infection in a subject comprising administering to the subject a prophylactically or therapeutically effective amount of a vaccine composition, wherein the vaccine comprises (i) the poxvirus of interest When a single DNA fragment, or two or more DNA fragments, comprising the entire genome of two or more DNA fragments, each comprising a partial sequence of the genome of the poxvirus desired to cause, and (ii) one or more DNA encoding one or more antigens, subunits or fragments thereof inserted into one or more insertion sites of the poxvirus sequence or other heterologous DNA sequence, wherein the antigen, subunit or fragment thereof or other heterologous DNA sequence is expressed in a host cell upon transfection of one or more DNA fragments and reconstitution of a poxvirus. In certain embodiments, the antigen, subunit or fragment thereof or other heterologous DNA sequence is inserted at one or more poxvirus insertion sites.
본 출원은 컬러로 작성된 적어도 1개의 도면을 함유한다. 컬러 도면을 갖는 본 출원의 사본은 요청 및 필요한 요금의 납부 시 관청에 의해 제공될 것이다.
도 1A-1C는 sMVA 구축의 설계도를 제시한다. 도 1A: MVA 게놈의 도식. MVA 게놈은 대략 178 kbp 길이이고 큰 ~9.6 kbp 길이의 역전된 말단 반복부들 (ITR)에 의해 플랭킹된 내부 고유 영역 (UR)을 함유한다. 도 1B: sMVA 단편의 도식. 3개의 sMVA 단편 각각은 대략 60 kbp 길이이다. sMVA 단편 1 (F1)은 좌측 ITR을 포함하는 MVA 게놈의 좌측 부분의 서열을 함유하고; sMVA 단편 2 (F2)는 MVA 게놈의 중간 부분의 서열을 함유하고; sMVA 단편 3 (F3)은 우측 ITR을 포함하는 MVA 게놈의 우측 부분의 서열을 함유한다. sMVA F1 및 F2 뿐만 아니라 sMVA F2 및 F3은 상동성 재조합을 위한 ~3 kbp 중첩된 서열 (교차된 점선)을 공유한다. sMVA F1 내 Del2, IGR44/45 (44/45), 및 IGR64/65 (69/70), sMVA F2 내 IGR69/70 (69/70) 및 TK 삽입 부위, 및 sMVA F3 내 Del3을 포함하는, 통상적으로 사용되는 MVA 삽입 부위의 대략적인 위치가 표시되어 있다. 도 1C: 말단 HL 및 CR 서열의 도식. 각각의 sMVA 단편은 양쪽 단부에 게놈 분해 및 패키징을 촉진하기 위해 MVA 말단 HL 및 플랭킹 CR 서열의 이중체 카피를 포함하는 서열 조성을 함유한다. SfiI 및 FseI 제한 부위가 효소적 소화에 의해 말단 CR/HL/CR 서열과 함께 또는 없이 박테리아 벡터 백본 (pCCI-브릭(Brick))으로부터 단편을 방출하기 위해 나타낸 바와 같이 각각의 sMVA 단편의 양쪽 단부에 포함된다.
도 2는 sMVA의 재구성을 제시한다. 도 1에 제시된 바와 같은 3개의 sMVA 단편 (F1-F3)을 사용하는 sMVA (sMVA)의 생성에 대한 도식이 도시된다. 3개의 sMVA 단편은 이. 콜라이(E. coli)에서 안정하게 유지되고, 이어서 박테리아로부터 단리되고 형질감염에 의해 원형 또는 선형화된 DNA 분자로서 MVA 허용성 BHK 또는 CEF 세포로 전달된다. 형질감염된 세포는 후속적으로 헬퍼 바이러스로서의 계두 바이러스 (FPV)로 감염되어 MVA 게놈 전사 및 복제 및 결과적으로 바이러스 형태의 sMVA의 재구성을 개시한다.
도 3은 1개의 항원을 갖는 재조합 sMVA의 구축을 도시한다. 1개의 도입된 항원 서열, 이종성 유전자 서열, 또는 다른 게놈 변경을 갖는 재조합 sMVA (rsMVA)의 구축의 예에 대한 도식이 제시된다. 항원 또는 이종성 유전자 서열 (흑색 원)은 선형 PCR-유래된 산물 또는 다른 형태의 선형 DNA 구축물을 사용하는 이. 콜라이에서의 박테리아 재조합 방법에 의해 F2 (또는 다른 sMVA 단편 (F1 또는 F3) 중 하나)의 MVA 게놈 서열로 삽입된다. 변형된 sMVA 단편 F1 및 비변형된 sMVA 단편 F2 및 F3은 이. 콜라이로부터 단리되고 원형 또는 선형화된 형태로서 FPV-감염된 BHK 또는 CEF 세포로 공동-형질감염되어 1개의 항원 또는 이종성 유전자 서열을 발현하는 rsMVA의 재구성을 개시한다. Nucl. = 세포 핵.
도 4는 3개의 항원을 갖는 재조합 sMVA의 구축을 예시한다. 3개의 도입된 항원 서열, 이종성 유전자 서열, 또는 다른 게놈 변경을 갖는 재조합 sMVA (rsMVA)의 생성의 예에 대한 도식이 제시된다. 항원 또는 이종성 유전자 서열 (정사각형, 원, 또는 직사각형으로 제시됨)은 선형 PCR-유래된 산물 또는 다른 형태의 선형 DNA 구축물을 사용하는 이. 콜라이에서의 박테리아 재조합 기술에 의해 3개의 sMVA 단편 (F1-F3) 각각으로 삽입된다. 변형된 F1, F2, 및 F3 sMVA 단편은 이. 콜라이로부터 단리되고 원형 또는 선형화된 형태로 허용성 BHK 또는 CEF 세포로 공동-형질감염되고, 여기서 3개의 항원 또는 이종성 유전자 서열을 발현하는 rsMVA 바이러스는 헬퍼 바이러스로서의 FPV의 존재 하에 재구성된다. Nucl. = 세포 핵.
도 5는 sMVA 재구성 과정을 예시한다. 3개의 sMVA 단편 (F1-F3) 또는 그의 변형된 형태를 사용하는 sMVA 또는 rsMVA의 조직 배양 재구성 과정의 예에 대한 도식이 제시된다. 6-웰 조직 배양 포맷에 시딩된 BHK 세포는 3개의 sMVA 단편 (비변형됨, 변형됨, 또는 이들의 조합)으로 공동-형질감염되고 후속적으로 헬퍼 바이러스로서의 FPV로 감염되어 sMVA 단편의 전사 및 복제 및, 결과적으로, sMVA 바이러스의 재구성을 개시한다. 형질감염된/감염된 BHK 세포는 나타낸 바와 같이 sMVA 재구성을 촉진하기 위해 격일로 (형질감염/감염 후 2일, 4일, 및 6일 (dpt/i)에) 보다 큰 조직 배양 포맷으로 옮겨진다. 플라크 발생 및 진행은 2일차 및 4일차 세포 이동 후에 검출될 수 있고, 6일차 이동 후 7 또는 8 dpt/i에 90-100% 감염된 BHK 세포를 야기한다.
도 6A-6B는 sMVA 감염성 분석을 제시한다. 도 6A는 감염 후 1일 (dpi)에서의 sMVA 또는 MVA NIH 클론 1로 감염된 BHK 세포 단층의 5개의 개별 플라크의 대표적인 명시야 현미경 이미지를 나타내는 플라크 분석이다. 도 6B는 감염의 진행을 제시한다. 1, 2, 및 3 dpi에서의 sMVA 또는 MVA NIH 클론 1로 감염된 BHK 세포 단층의 대표적인 명시야 현미경 이미지가 제시된다. 모의-감염된 (비감염된) BHK 세포 단층이 대조군으로서 분석되었다. 플라크 및 감염된 구역은 백시니아 바이러스 B5R 단백질에 대한 면역염색에 의해 시각화되었다.
도 7A-7L은 재구성된 sMVA의 PCR 분석을 제시한다. BHK 세포는 MOI 5로 3개의 sMVA 단편 (F1-F3) 또는 MVA NIH 클론 1로부터 재구성된 sMVA 바이러스로 감염되었고 감염된 BHK 세포로부터 추출된 DNA가 PCR에 의해 평가되었다. 모의-감염된 (비감염된) BHK 세포 (BHK)로부터 추출된 DNA 뿐만 아니라 H2O 단독 (Ctrl)이 대조군을 위해 분석되었다. PCR 분석은 역전된 말단 반복부 (ITR) (도 7A); sMVA F1-유래된 DNA에 위치한, 좌측 ITR로부터 내부 고유 영역으로의 전이 (LITR/UR) (도 7B) 및 MVA 결실 2 부위 (Del2) (도 7C); sMVA F2-유래된 DNA에 위치한 MVA 69R과 70L 사이의 유전자간 영역 (IGR) (IGR69/70) (도 7D); sMVA F3-유래된 DNA에 위치한, MVA 결실 3 부위 (Del3) (도 7E) 및 내부 UR로부터 우측 ITR로의 전이 (UR/RITR) (도 7F); sMVA F1 및 F2 (F1/F2) (도 7G) 뿐만 아니라 F2 및 F3 (F2/F3) (도 7H)의 재조합 부위의 재구성; 및 MVA 균주 앙투안(Antoine)에 특이적인 5종의 뉴클레오티드 다형성 (Polym. 1, 2, 3, 4/5)을 함유하는 MVA 게놈 위치 (도 7I-7L)의 서열 검출을 포함하였다. 예상되는 PCR 산물은 화살표에 의해 각각의 패널의 우측에 표시된다. PCR 산물의 예상되는 크기는 각각의 패널 아래에 괄호로 제공된다.
도 8은 단일 형광 마커를 사용하여 sMVA의 재구성을 제시한다. 비변형된 sMVA 단편 F1 및 F3 및 삽입된 적색 형광 단백질 (RFP) 마커를 갖는 변형된 sMVA 단편 F2 (F2-RFP)를 사용한, 형질감염/감염 후 6일 및 7일 (dpt/i)에서의 BHK 세포 단층의 대표적인 면역형광 및 명시야 현미경 이미지가 제시된다. 이들 단편으로부터의 sMVA 재구성 절차는 도 5에 예시되고 FPV가 헬퍼 바이러스로서 사용되었다. 모의-형질감염된/감염된 BHK 세포 단층이 대조군으로서 분석되었다.
도 9는 이중 형광 마커를 사용하여 sMVA의 재구성을 제시한다. 비변형된 sMVA 단편 F1, 삽입된 적색 형광 단백질 (RFP) 마커를 갖는 변형된 sMVA 단편 F2 (F2-RFP), 및 삽입된 청색 형광 단백질 (BFP) 마커를 갖는 변형된 sMVA 단편 F3 (F3-BFP)을 사용한, 형질감염/감염 후 6일 및 7일 (dpt/i)에서의 BHK 세포 단층의 대표적인 면역형광 및 명시야 현미경 이미지가 제시된다. 이들 단편으로부터의 sMVA 재구성 절차는 도 5에 예시되고 FPV가 헬퍼 바이러스로서 사용되었다. 모의-형질감염된/감염된 BHK 세포 단층이 대조군으로서 분석되었다.
도 10A-10H는 rsMVA HCMV 벡터 구축의 다양한 예를 예시한다. 오량체 복합체의 5개의 서브유닛 (PC; UL128, UL130, UL131A, gH, 및 gL을 포함함)에 기반한 삽입된 HCMV 항원 서열, 당단백질 B (gB), 인단백질 65 (pp65), 및/또는 극초기 단백질 1 및 2 (IE1 및 IE2)를 갖는 rsMVA 벡터를 생성하기 위한 sMVA 단편 F1-F3의 사용에 대한 예가 제시된다. HCMV 항원 서열은 나타낸 바와 같이 개별적으로 또는 2A-연결된 폴리시스트론 발현 구축물로 조합되어, MVA 결실 3 (Del3) 부위 또는 오픈 리딩 프레임 044/045 (44/45), 064/065 (64/65), 또는 069/070 (69/70) 사이의 유전자간 영역을 포함하는 상이한 MVA 삽입 부위로 삽입된다. 모든 PC 서브유닛 (sMVA-PC1 (도 10A) 및 sMVA-PC2 (도 10B)), gB 및 pp65와 함께 모든 PC 서브유닛 (sMVA-7Ag1 (도 10C) 및 sMVA-7Ag2 (도 10D)), 또는 IE1/IE2 항원과 함께 모든 PC 서브유닛, gB, 및 pp65 (sMVA-8Ag1/2 (도 10E-10F)) 및 sMVA-9Ag2 (도 10G-10H))를 발현하는 rsMVA 벡터에 대한 예가 제공된다. mH5는 백시니아 변형된 H5 프로모터를 나타내고, ITR은 역전된 말단 반복부를 나타낸다.
도 11A-11B는 sMVA 특징규명을 제시한다. 도 11A: PCR 분석. FPV HP1.441로 유래된 sMVA로 감염된 CEF (sMVA hp) 또는 2개의 독립적인 바이러스 재구성으로부터의 TROVAC (sMVA tv1 및 sMVA tv2)가 PCR에 의해 여러 MVA 게놈 위치 (ITR 서열, 내부 고유 영역으로의 좌측 또는 우측 ITR 전이 (좌측 ITR/UR; UR/우측 ITR), Del2, IGR69/70 및 Del3 삽입 부위, 및 F1/F2 및 F2/F3 재조합 부위) 및 BAC 벡터 서열의 부재에 대해 조사되었다. wtMVA-감염된 및 비감염된 세포를 사용한, 샘플이 없는 (모의), 또는 MVA BAC를 사용한 PCR 반응이 대조군으로서 수행되었다. 도 11B: 제한 단편 길이 분석. 초정제된 sMVA (sMVA tv1 및 sMVA tv2) 또는 wtMVA 바이러스로부터 단리된 바이러스 DNA가 KpnI 및 XhoI 제한 효소 소화에 의해 비교되었다.
도 12A-12D는 sMVA 복제 특성을 제시한다. FPV HP1.441로 유래된 sMVA (sMVA hp) 또는 2개의 독립적인 sMVA 바이러스 재구성으로부터의 TROVAC (sMVA tv1 및 sMVA tv2)의 복제 특성이 wtMVA와 비교되었다. 도 12A: 바이러스 포커스. 낮은 감염다중도 (MOI)로 재구성된 sMVA 바이러스 또는 wtMVA로 감염된 CEF는 항-백시니아 폴리클로날 항체 (αVAC)를 사용하여 면역염색되었다. 도 12B: 복제 속도. BHK 또는 CEF 세포는 0.02 MOI로 sMVA 또는 wtMVA로 감염되었고 감염 후 24시간 및 48시간에서의 접종물 및 감염된 세포의 바이러스 역가가 CEF 상에서 결정되었다. 가이써-그린하우스(Geisser-Greenhouse) 보정을 사용한 혼합-효과 모델이 적용되었고; 감염 후 24시간 및 48시간에서의 그룹 사이의 차이는 유의하지 않았다. 도 12C: 바이러스 포커스 크기 분석. BHK 또는 CEF 세포 단층은 0.002 MOI로 sMVA 또는 wtMVA로 감염되었고 바이러스 포커스의 면적이 감염 후 24시간에 αVAC 항체를 사용한 면역염색 후 결정되었다. 도 12D: 숙주 세포 범위 분석. 다양한 인간 세포주 (HEK293, A549, 143b, 및 HeLa), CEF 또는 BHK 세포는 0.01 MOI로 sMVA 또는 wtMVA로 감염되었고 바이러스 역가가 감염 후 48시간에 CEF 상에서 결정되었다. 점선은 0.01 MOI에 기반한 접종물의 계산된 바이러스 역가를 나타낸다. 도 12C-12D의 그룹 사이의 차이는 일원 ANOVA에 이어서 터키(Tukey) (2C) 또는 던넷(Dunnett) (2D) 다중 비교 검정을 사용하여 계산되었다. ns = 유의하지 않음.
도 13A-13D는 sMVA 생체내 면역원성을 입증한다. FPV HP1.441 (sMVA hp) 또는 2개의 독립적인 바이러스 재구성으로부터의 TROVAC (sMVA tv1 및 sMVA tv2)로 유래된 sMVA가 시험관내 분석에 의해 wtMVA와 비교되었다. C57BL/6 마우스는 3주 간격으로 낮은 (1x107 PFU) 또는 높은 (5x107 PFU) 용량의 sMVA 또는 wtMVA로 2회 면역화되었다. 모의-면역화된 마우스가 대조군으로서 사용되었다. 도 13A: 결합 항체. sMVA 또는 wtMVA에 의해 자극된 MVA-특이적 결합 항체 (IgG 역가)가 제1 및 제2 면역화 후에 ELISA에 의해 측정되었다. 도 13B: NAb 반응. sMVA 또는 wtMVA에 의해 유도된 MVA-특이적 NAb 역가가 부스터 면역화 후에 GFP 마커를 발현하는 재조합 wtMVA에 대해 측정되었다. 도 13C-13D: T 세포 반응. 2회의 면역화 후, sMVA 또는 wtMVA에 의해 유도된 MVA-특이적 IFNγ, TNFα, IL-4, 및 IL-10-분비 CD8+ (13C) 및 CD4+ (13D) T 세포 반응이 B8R 면역우세 펩티드를 사용하는 생체외 항원 자극 후 유세포 분석에 의해 측정되었다. 그룹 사이의 차이는 터키 다중 비교 검정을 사용한 일원 ANOVA를 사용하여 평가되었다. ns = 유의하지 않음.
도 14A-14D는 생체내 sMVA 면역원성을 입증한다. FPV 균주 HP1.441 (sMVA hp) 또는 2개의 독립적인 바이러스 재구성으로부터의 FPV 균주 TROVAC (sMVA tv1 및 sMVA tv2)로 유래된 sMVA가 시험관내 분석에 의해 wtMVA와 비교되었다. C57BL/6 마우스 (N=4)는 3주 간격으로 낮은 (1x107 PFU) 또는 높은 (5x107 PFU) 용량의 sMVA 또는 wtMVA로 2회 면역화되었다. 모의-면역화된 마우스가 대조군으로서 사용되었다. 도 14A: 결합 항체. sMVA 또는 wtMVA를 받은 마우스에서 제1 및 제2 면역화 후 ELISA에 의해 측정된 MVA-특이적 결합 항체 (IgG 역가)의 상이한 혈청 희석에서 450 nm에서의 흡광도가 제시된다. 도 14B: NAb 반응. sMVA 또는 wtMVA에 의해 유도된 MVA-특이적 NAb 역가가 부스터 면역화 후 GFP 마커를 발현하는 wtMVA에 대해 측정되었다. 상이한 혈청 희석에서 감염된 세포의 측정된 GFP 면적 (정방향 픽셀 (pix2x103))이 제시된다. 도 14C-14D: T 세포 반응. IFNγ, TNFα, IL-4, 및 IL-10을 발현하는 MVA-특이적 CD8+ (14C) 및 CD4+ (14D) T 세포가 sMVA 또는 wtMVA로의 2회의 면역화 후, 백시니아 A19L 면역우세 펩티드를 사용하는 생체외 항원 자극 후 유세포 분석에 의해 측정되었다. 그룹 사이의 차이는 터키 다중 비교 검정을 사용한 일원 ANOVA를 사용하여 평가되었다. ns = 유의하지 않음.This application contains at least one drawing made in color. Copies of this application with color drawings will be provided by the Office upon request and payment of the necessary fees.
1A-1C present schematics of sMVA construction. 1A: Schematic of the MVA genome. The MVA genome is approximately 178 kbp long and contains an internal native region (UR) flanked by inverted terminal repeats (ITRs) of large ˜9.6 kbp length. 1B: Schematic of the sMVA fragment. Each of the three sMVA fragments is approximately 60 kbp in length. sMVA fragment 1 (F1) contains the sequence of the left portion of the MVA genome including the left ITR; sMVA fragment 2 (F2) contains the sequence of the middle portion of the MVA genome; sMVA fragment 3 (F3) contains the sequence of the right portion of the MVA genome including the right ITR. sMVA F1 and F2 as well as sMVA F2 and F3 share a ~3 kbp overlapping sequence (crossed dotted lines) for homologous recombination. Common, including Del2, IGR44/45 (44/45), and IGR64/65 (69/70) in sMVA F1, IGR69/70 (69/70) and TK insertion sites in sMVA F2, and Del3 in sMVA F3 The approximate location of the MVA insertion site used as 1C: Schematic of terminal HL and CR sequences. Each sMVA fragment contains a sequence composition comprising duplex copies of the MVA terminal HL and flanking CR sequences at both ends to facilitate genomic digestion and packaging. SfiI and Fsel restriction sites at both ends of each sMVA fragment as shown to release the fragment from the bacterial vector backbone (pCCI-Brick) with or without terminal CR/HL/CR sequences by enzymatic digestion Included.
Figure 2 presents the reconstruction of sMVA. A schematic for the generation of sMVA (sMVA) using three sMVA fragments (F1-F3) as shown in FIG. 1 is shown. The three sMVA fragments are from E. It is stably maintained in E. coli and then isolated from the bacteria and transferred to MVA-permissive BHK or CEF cells as circular or linearized DNA molecules by transfection. Transfected cells are subsequently infected with fowlpox virus (FPV) as a helper virus to initiate MVA genome transcription and replication and consequently reconstitution of sMVA in its viral form.
3 depicts the construction of recombinant sMVA with one antigen. A schematic is presented for an example of construction of recombinant sMVA (rsMVA) with one introduced antigen sequence, heterologous gene sequence, or other genomic alteration. Antigen or heterologous gene sequences (black circles) are either linear PCR-derived products or other types of linear DNA constructs using E. It is inserted into the MVA genomic sequence of F2 (or one of the other sMVA fragments (F1 or F3)) by bacterial recombination methods in E. coli. The modified sMVA fragment F1 and the unmodified sMVA fragment F2 and F3 are E. E. coli isolated and co-transfected with FPV-infected BHK or CEF cells in circular or linearized form to initiate reconstitution of rsMVA expressing one antigen or heterologous gene sequence. Nucl. = cell nucleus.
Figure 4 illustrates the construction of recombinant sMVA with three antigens. A schematic is presented for an example of the generation of recombinant sMVA (rsMVA) with three introduced antigen sequences, heterologous gene sequences, or other genomic alterations. Antigen or heterologous gene sequences (shown as squares, circles, or rectangles) can be generated using linear PCR-derived products or other types of linear DNA constructs. It is inserted into each of the three sMVA fragments (F1-F3) by bacterial recombination in E. coli. The modified F1, F2, and F3 sMVA fragments are from E. E. coli and co-transfected into permissive BHK or CEF cells in circular or linearized form, wherein the rsMVA virus expressing three antigens or heterologous gene sequences is reconstituted in the presence of FPV as a helper virus. Nucl. = cell nucleus.
5 illustrates the sMVA reconstruction process. A schematic is presented for an example of a tissue culture reconstitution process of sMVA or rsMVA using three sMVA fragments (F1-F3) or modified forms thereof. BHK cells seeded in a 6-well tissue culture format were co-transfected with three sMVA fragments (unmodified, modified, or a combination thereof) and subsequently infected with FPV as a helper virus to induce transcription of the sMVA fragment and replication and, consequently, reconstitution of the sMVA virus. Transfected/infected BHK cells are transferred to a larger tissue culture format every other day (at 2, 4, and 6 days post-transfection/infection (dpt/i)) to facilitate sMVA reconstitution as indicated. Plaque development and progression can be detected after
6A-6B present the sMVA infectivity assay. 6A is a plaque assay showing representative brightfield microscopy images of five individual plaques of BHK cell monolayers infected with either sMVA or
7A-7L show PCR analysis of reconstituted sMVA. BHK cells were infected with three sMVA fragments (F1-F3) or sMVA virus reconstituted from
Figure 8 presents the reconstruction of sMVA using a single fluorescent marker. At 6 and 7 days (dpt/i) post-transfection/infection with unmodified sMVA fragments F1 and F3 and modified sMVA fragment F2 (F2-RFP) with inserted red fluorescent protein (RFP) marker. Representative immunofluorescence and bright field microscopy images of BHK cell monolayers are shown. The sMVA reconstitution procedure from these fragments is illustrated in Figure 5 and FPV was used as a helper virus. Mock-transfected/infected BHK cell monolayers were analyzed as controls.
Figure 9 presents the reconstruction of sMVA using dual fluorescent markers. Unmodified sMVA fragment F1, modified sMVA fragment F2 with an inserted red fluorescent protein (RFP) marker (F2-RFP), and modified sMVA fragment F3 with an inserted blue fluorescent protein (BFP) marker (F3-BFP) ) are shown representative immunofluorescence and brightfield microscopy images of BHK cell monolayers at 6 and 7 days post-transfection/infection (dpt/i). The sMVA reconstitution procedure from these fragments is illustrated in Figure 5 and FPV was used as a helper virus. Mock-transfected/infected BHK cell monolayers were analyzed as controls.
10A-10H illustrate various examples of rsMVA HCMV vector construction. Inserted HCMV antigen sequence based on the 5 subunits of the pentameric complex (PC; including UL128, UL130, UL131A, gH, and gL), glycoprotein B (gB), phosphoprotein 65 (pp65), and/or An example is given of the use of the sMVA fragment F1-F3 to generate an rsMVA vector with very
11A-11B present sMVA characterization. 11A: PCR analysis. CEFs infected with sMVA derived from FPV HP1.441 (sMVA hp) or TROVAC from two independent viral reconstitutions (sMVA tv1 and sMVA tv2) were identified by PCR at multiple MVA genomic locations (ITR sequence, left to internal native region). or right ITR transitions (left ITR/UR; UR/right ITR), Del2, IGR69/70 and Del3 insertion sites, and F1/F2 and F2/F3 recombination sites, and absence of BAC vector sequences. PCR reactions using wtMVA-infected and uninfected cells, no samples (mock), or using MVA BAC were performed as controls. 11B: Restriction fragment length analysis. Viral DNA isolated from ultra-purified sMVA (sMVA tv1 and sMVA tv2) or wtMVA virus was compared by KpnI and XhoI restriction enzyme digestion.
12A-12D present sMVA replication characteristics. The replication properties of sMVA (sMVA hp) derived from FPV HP1.441 or TROVAC (sMVA tv1 and sMVA tv2) from two independent sMVA virus reconstitutions were compared with wtMVA. 12A: Virus focus. CEFs infected with sMVA virus or wtMVA reconstituted at low multiplicity of infection (MOI) were immunostained using anti-vaccinia polyclonal antibody (αVAC). 12B: Replication rate. BHK or CEF cells were infected with sMVA or wtMVA at an MOI of 0.02 and the viral titers of inoculum and infected cells at 24 and 48 hours post infection were determined on CEF. A mixed-effect model using Geisser-Greenhouse corrections was applied; Differences between groups at 24 and 48 hours post infection were not significant. 12C: Virus focus size analysis. BHK or CEF cell monolayers were infected with sMVA or wtMVA at an MOI of 0.002 and the area of viral foci was determined after immunostaining with
13A-13D demonstrate sMVA in vivo immunogenicity. sMVA derived from FPV HP1.441 (sMVA hp) or TROVAC (sMVA tv1 and sMVA tv2) from two independent viral reconstitutions were compared to wtMVA by in vitro assays. C57BL/6 mice were immunized twice with low (1×10 7 PFU) or high (5×10 7 PFU) doses of sMVA or wtMVA at 3-week intervals. Mock-immunized mice were used as controls. Figure 13A: Binding antibody. MVA-specific binding antibodies (IgG titers) stimulated by sMVA or wtMVA were measured by ELISA after the first and second immunizations. Figure 13B: NAb reaction. MVA-specific NAb titers induced by sMVA or wtMVA were measured against recombinant wtMVA expressing GFP markers after booster immunization. 13C-13D: T cell response. After two immunizations, MVA-specific IFNγ, TNFα, IL-4, and IL-10-secreting CD8+ (13C) and CD4+ (13D) T cell responses induced by sMVA or wtMVA were compared with B8R immunodominant peptides. Measured by flow cytometry after ex vivo antigen stimulation. Differences between groups were assessed using one-way ANOVA using the Turkish multiple comparison test. ns = not significant.
14A-14D demonstrate sMVA immunogenicity in vivo. sMVA derived from FPV strain HP1.441 (sMVA hp) or FPV strain TROVAC (sMVA tv1 and sMVA tv2) from two independent viral reconstitutions were compared to wtMVA by in vitro assays. C57BL/6 mice (N=4) were immunized twice with low (1×10 7 PFU) or high (5×10 7 PFU) doses of sMVA or wtMVA at 3-week intervals. Mock-immunized mice were used as controls. 14A: Binding antibody. The absorbance at 450 nm at different serum dilutions of the MVA-specific binding antibody (IgG titer) measured by ELISA after the first and second immunizations in mice receiving either sMVA or wtMVA is shown. 14B: NAb reaction. MVA-specific NAb titers induced by sMVA or wtMVA were measured against wtMVA expressing GFP markers after booster immunization. The measured GFP area (forward pixels (pix 2 ×10 3 )) of infected cells at different serum dilutions is shown. 14C-14D: T cell response. MVA-specific CD8+ (14C) and CD4+ (14D) T cells expressing IFNγ, TNFα, IL-4, and IL-10 in vivo with vaccinia A19L immunodominant peptide after two immunizations with sMVA or wtMVA It was measured by flow cytometry after exogenous antigen stimulation. Differences between groups were assessed using one-way ANOVA using the Turkish multiple comparison test. ns = not significant.
원형화된 또는 선형화된, 천연적으로 유래된 또는 화학적으로 합성된 DNA로부터 폭스바이러스-기반 벡터 및 재조합 폭스바이러스 벡터를 생산하는 방법이 본원에 개시된다. 특정 예가 원형화된 합성 DNA 단편으로부터 MVA의 전체 합성 버전 (sMVA) 뿐만 아니라 형광 마커 또는 감염성 질환 및 암 항원을 포함하는 하나 이상의 이종성 유전자 서열을 발현하는 재조합 sMVA (rsMVA)을 생산하기 위해 제공된다.Disclosed herein are methods for producing poxvirus-based vectors and recombinant poxvirus vectors from circularized or linearized, naturally derived or chemically synthesized DNA. Specific examples are provided for producing fully synthetic versions of MVA (sMVA) from circularized synthetic DNA fragments as well as recombinant sMVA (rsMVA) expressing one or more heterologous gene sequences comprising fluorescent markers or infectious disease and cancer antigens.
그의 다목적 발현 시스템 및 외래 DNA 서열 (최대 30 kbp)을 수용하는 큰 능력에 더하여 그의 우수한 안정성 프로파일 때문에1, MVA는 감염 질환 및 암에 대한 재조합 백신 벡터를 개발하는 데 널리 사용된다 7,12,13. MVA는 암 치료를 위한 상이한 백신 전략14,15 뿐만 아니라 신생아에서의 영구적인 선천성 결함 및 이식 수용자에서의 합병증의 통상적인 원인19인 인간 시토메갈로바이러스(cytomegalovirus) (HCMV) 감염을 예방하기 위한 다양한 백신 접근법16-18을 개발하기 위해 추구되어 왔다. 이들 백신 중 일부는 임상 I상 또는 II상 평가를 완료하였다14,17. 폭스바이러스 과의 구성원으로서, MVA는 감염된 세포의 세포질에서 완전히 복제하여, 전사 및 DNA 복제를 위한 그의 자체 효소를 제공한다1,20. 비록 MVA 바이러스 생산이 포유류 세포에서 조립의 후기 차단 때문에 중단되지만, MVA는 인간 세포를 포함하는 대부분의 포유류 세포를 효율적으로 감염시키고, 강력한 유전자 발현 및 DNA 복제를 개시할 수 있고, 이는 MVA를 외래 항원을 효율적으로 시험관내 및 생체내 전달하고 발현하는 이상적인 비히클로 만든다1,5. 가장 통상적으로 사용되는 MVA 재조합체를 생성하는 방법은 MVA와 함께 허용성 세포 (CEF 또는 BHK)로 공동-전달되는 전달 플라스미드를 사용함로써, 상류 프로모터 서열 및 하류 전사 종결 신호와 함께 목적하는 항원을 자발적인 상동성 재조합에 의해 MVA 게놈으로 삽입하는 소위 형질감염/감염 방법에 기반한다1,5,21.Because of its versatile expression system and large ability to accommodate foreign DNA sequences (up to 30 kbp), in addition to its excellent stability profile 1 , MVA is widely used to develop recombinant vaccine vectors against infectious diseases and cancer 7,12,13 . MVA is a versatile vaccine to prevent human cytomegalovirus (HCMV) infection, a common cause of permanent birth defects in newborns and complications in transplant recipients 19 as well as different vaccine strategies 14,15 for the treatment of cancer. Approaches 16-18 have been sought to develop. Some of these vaccines have completed Phase I or II clinical evaluation 14,17 . As a member of the poxvirus family, MVA replicates fully in the cytoplasm of infected cells, providing its own enzymes for transcription and DNA replication 1,20 . Although MVA virus production is halted due to a late blockade of assembly in mammalian cells, MVA can efficiently infect most mammalian cells, including human cells, and initiate robust gene expression and DNA replication, which causes MVA to bind to foreign antigens. This makes it an ideal vehicle for efficient in vitro and in vivo delivery and expression of 1,5 . The most commonly used method for generating MVA recombinants is the use of a transfer plasmid that is co-delivered into permissive cells (CEF or BHK) with MVA, whereby the desired antigen along with an upstream promoter sequence and a downstream transcription termination signal is spontaneously transferred. It is based on the so-called transfection/infection method, which inserts into the MVA genome by homologous recombination 1,5,21 .
비록 이 방법이 널리 사용되지만, 이는 어려울 수 있고 항원 삽입 동안 및 추가적으로 재조합 MVA의 균질한 집단을 수득하기 위한 후속 마커 제거 동안 여러 라운드의 선택에 의해 방해된다21. 종래의 형질감염/감염 방법에서의 이들 문제점은 특히 2개 이상의 삽입 부위로 삽입된 항원을 갖는 다중항원 MVA 벡터의 생성에 대해 문제가 있을 수 있고, 이는 MVA 백신 안정성을 감소시킬 수 있다18,22. 종래의 형질감염/감염 방법에 대한 대안으로서 및 다중항원 MVA 벡터의 생성을 용이하게 하기 위해, 박테리아 인공 염색체 (BAC) 기술을 사용하여 MVA 재조합체를 생성하는 방법이 개발되어 왔다23-25. 이들 방법은 반복된 조작으로 하여금 매우 효율적이고 다목적인 돌연변이유발 기술에 의해 항원을 MVA 게놈으로 삽입하고 BHK 세포에서 비감염성 MVA 게놈의 전사를 "점프-스타트(jump-start)"하는 데 요구되는 헬퍼 바이러스로서 계두 바이러스 (FPV)를 사용하여 재조합 MVA의 균질한 바이러스 집단을 재구성하게 한다23.Although this method is widely used, it can be difficult and hampered by several rounds of selection during antigen insertion and additionally during subsequent marker removal to obtain a homogeneous population of recombinant MVA 21 . These problems with conventional transfection/infection methods can be particularly problematic for the generation of multiantigen MVA vectors with antigens inserted into two or more insertion sites, which can reduce MVA vaccine stability 18,22 . As an alternative to conventional transfection/infection methods and to facilitate the production of multiantigen MVA vectors, methods for generating MVA recombinants using bacterial artificial chromosome (BAC) technology have been developed 23-25 . These methods allow repeated manipulations to insert antigen into the MVA genome by a highly efficient and versatile mutagenesis technique and the helpers required to "jump-start" the transcription of the non-infectious MVA genome in BHK cells. The use of fowlpox virus (FPV) as a virus allows reconstitution of a homogeneous viral population of recombinant MVA 23 .
합성 폭스바이러스의 구축Construction of synthetic poxviruses
천연적으로 유래된 또는 화학적으로 합성된 DNA로부터 폭스바이러스-기반 벡터 또는 재조합 폭스바이러스 벡터를 생산하는 방법이 본원에 개시된다. 특정 실시양태에서, 단일 DNA 단편은 바이러스 DNA로부터 유래되거나 또는 화학적으로 합성되고 폭스바이러스의 전체 게놈 서열을 포함한다. 이 단일 DNA 단편은 폭스바이러스가 재구성되도록 숙주 세포를 형질감염시키는 데 사용될 수 있다. 다른 실시양태에서, 2개 이상의 천연적으로 유래된 또는 화학적으로 합성된 DNA 단편, 또는 이들의 조합이 숙주 세포를 공동-형질감염시키는 데 사용되며, 여기서 각각의 DNA 단편은, 2개 이상의 DNA 단편이 숙주 세포로 공동-형질감염될 때, 이들이 상동성 재조합에 의해 서로 조립되어 목적하는 폭스바이러스 게놈의 전장 서열을 포함하는 폭스바이러스를 형성하도록 2개의 인접한 DNA 단편의 단부에서 중첩된 서열을 갖는 폭스바이러스 게놈 DNA의 부분적인 서열을 포함한다. 특정 실시양태에서, 중첩된 서열은 약 100 bp 내지 약 5000 bp 길이이다.Disclosed herein are methods of producing poxvirus-based vectors or recombinant poxvirus vectors from naturally derived or chemically synthesized DNA. In certain embodiments, a single DNA fragment is derived from or chemically synthesized from viral DNA and comprises the entire genome sequence of a poxvirus. This single DNA fragment can be used to transfect host cells such that the poxvirus is reconstituted. In other embodiments, two or more naturally derived or chemically synthesized DNA fragments, or a combination thereof, are used to co-transfect a host cell, wherein each DNA fragment comprises two or more DNA fragments. When co-transfected into this host cell, a pox having overlapping sequences at the ends of two adjacent DNA fragments such that they assemble together by homologous recombination to form a poxvirus comprising the full-length sequence of the desired poxvirus genome. Contains a partial sequence of viral genomic DNA. In certain embodiments, the overlapping sequence is from about 100 bp to about 5000 bp in length.
특정 실시양태에서, 전체 게놈 서열이 아닌 짧아진 게놈 서열 또는 폭스바이러스의 게놈 서열의 비필수 유전자 또는 영역에서 결실(들) 또는 변형(들)을 갖는 변경된 게놈 서열, 또는 2종 또는 다수의 상이한 폭스바이러스로부터의 게놈 서열을 포함하는 혼성 유도체가 본원에 개시된 벡터를 생산하는 데 사용될 수 있다.In certain embodiments, a shortened genomic sequence other than the whole genomic sequence or an altered genomic sequence having deletion(s) or modification(s) in a non-essential gene or region of the genomic sequence of a poxvirus, or two or more different pox Hybrid derivatives comprising genomic sequences from viruses can be used to produce the vectors disclosed herein.
특정 실시양태에서, 폭스바이러스 게놈 또는 서브게놈 DNA를 포함하는 하나 이상의 천연적으로 유래된 또는 화학적으로 합성된 DNA 단편(들)은 추가로 변형되어 천연 및 합성 폭스바이러스 게놈 DNA 서열로 구성된 인공 혼성체 단편을 형성할 수 있다. 다른 실시양태에서, 천연적으로 유래된 또는 화학적으로 합성된 하나 이상의 DNA 단편(들)은 2종의 상이한 폭스바이러스로부터 유래된 서열로 구성되어 폭스바이러스 혼성체 서열을 형성할 수 있다. 하나 이상의 DNA 단편(들)은 폭스바이러스 서열 또는 MVA (NCBI 수탁 #U94848, #AY603355), 백시니아 바이러스 (#NC_006998, #LT966077), 카멜폭스 바이러스(Camelpox virus) (#NC_003391), 우두 바이러스 (#NC_003663) 엑트로멜리아 바이러스(Ectromelia virus) (#NC_004105), 원숭이 두창 바이러스 (#NC_003310), 라쿤폭스 바이러스(Racoonpox virus) (#NC_027213), 스컹크폭스 바이러스(Skunkpox virus) (#NC_031038), 타테라폭스 바이러스(Taterapox virus) (#NC_008291), 바리올라 바이러스 (#NC_001611, #L22579), 벨로폭스 바이러스(Velopox virus) (#NC_031033), 카나리폭스 바이러스(Canarypox virus) (#NC_005309), 돈두 바이러스(Swinepox virus) (#NC_003389), FPV (#NC_002188, #MH734528), 점액종 바이러스(Myxoma virus) (#GQ409969), 양두 바이러스(Sheeppox virus) (NC_004002), 산양두 바이러스(Goatpox virus) (#NC_004003), (오르프 바이러스(Orf virus) #NC_005336), 토끼 섬유종 바이러스(Rabbit fibroma virus) (#NC_001266), 이들 폭스바이러스의 임의의 균주 변이체, 또는 임의의 다른 폭스바이러스 또는 이의 균주 변이체로부터 유래된 상이한 폭스바이러스 서열로 구성된 서열로 구성될 수 있다.In certain embodiments, one or more naturally-derived or chemically synthesized DNA fragment(s) comprising poxvirus genomic or subgenomic DNA is further modified to form an artificial hybrid composed of natural and synthetic poxvirus genomic DNA sequences. fragments can be formed. In other embodiments, one or more naturally derived or chemically synthesized DNA fragment(s) may be composed of sequences derived from two different poxviruses to form a poxvirus hybrid sequence. The one or more DNA fragment(s) is a poxvirus sequence or MVA (NCBI accession #U94848, #AY603355), vaccinia virus (#NC_006998, #LT966077), Camelpox virus (#NC_003391), vaccinia virus (# NC_003663) Ectromelia virus (#NC_004105), monkey smallpox virus (#NC_003310), Racoonpox virus (#NC_027213), Skunkpox virus (#NC_031038), taterapox Taterapox virus (#NC_008291), Variola virus (#NC_001611, #L22579), Velopox virus (#NC_031033), Canarypox virus (#NC_005309), Swinepox virus ) (#NC_003389), FPV (#NC_002188, #MH734528), Myxoma virus (#GQ409969), Sheeppox virus (NC_004002), Goatpox virus (#NC_004003), (Orff Virus (Orf virus #NC_005336), Rabbit fibroma virus (#NC_001266), any strain variant of these poxviruses, or any other poxvirus or strain variants thereof, consisting of different poxvirus sequences derived from It may consist of a sequence.
특정 실시양태에서, 숙주 세포는 폭스바이러스 게놈 또는 서브게놈 DNA의 서열을 포함하는 하나 이상의 DNA 단편의 형질감염 전에, 그 동안, 또는 그 후에 헬퍼 바이러스 예컨대 FPV로 감염된다. 헬퍼 바이러스는 숙주 세포를 감염시키고 폭스바이러스의 전사 및 복제의 개시를 허용하는 임의의 적합한 바이러스일 수 있다. 숙주 세포에서 폭스바이러스 DNA와 상동성 재조합을 겪지 않는 FPV가 예로서 본원에서 사용된다. 헬퍼 바이러스는 숙주 세포에서 복제할 수 없다. 더욱이, 헬퍼 바이러스, 예를 들어, 본 출원의 목적을 위한 FPV, 그 자체는 재구성된 폭스바이러스의 성분이 아니다. 특정 실시양태에서, 우두 바이러스, 쇼프 섬유종 바이러스(Shope fibroma virus), 또는 다른 적합한 폭스바이러스가 헬퍼 바이러스로서 사용될 수 있다. 특정 실시양태에서, 형질감염을 위한 하나 이상의 DNA 단편은 선형화되거나, 원형화되거나, 또는 선형화된 및 원형화된 DNA 단편의 조합일 수 있다. 특정 실시양태에서, 형질감염을 위한 하나 이상의 DNA 단편은 벡터 예컨대 플라스미드 또는 BAC로 클로닝되고/거나 숙주 세포 예컨대 박테리아 세포, 예를 들어, 이. 콜라이에서 유지된다.In certain embodiments, the host cell is infected with a helper virus such as FPV prior to, during, or after transfection of one or more DNA fragments comprising sequences of poxvirus genomic or subgenomic DNA. The helper virus may be any suitable virus that infects a host cell and allows the initiation of transcription and replication of the poxvirus. FPV that does not undergo homologous recombination with poxvirus DNA in a host cell is used herein as an example. Helper viruses cannot replicate in host cells. Moreover, a helper virus, eg FPV for the purposes of the present application, is not itself a component of the reconstituted poxvirus. In certain embodiments, vaccinia virus, Shope fibroma virus, or other suitable poxvirus may be used as the helper virus. In certain embodiments, one or more DNA fragments for transfection may be linearized, circularized, or a combination of linearized and circularized DNA fragments. In certain embodiments, one or more DNA fragments for transfection are cloned into a vector such as a plasmid or BAC and/or a host cell such as a bacterial cell, eg, E. maintained in coli.
특정 실시양태에서, 하나 이상의 DNA 단편(들)은 폭스바이러스의 1개 또는 양쪽의 역전된 말단 반복부 (ITR) 영역을 추가로 포함한다. 특정 실시양태에서, ITR의 서열은 재구성된 폭스바이러스의 설계 계획에 영향을 미치지 않는 하나 이상의 변경 또는 변이를 함유할 수 있다. 하나의 실시양태에서, 폭스바이러스를 재구성하는 하나 이상의 DNA 단편은 단지 ITR 서열의 일부만을 함유할 수 있다. 예를 들어, sMVA 단편 F1 및 F3 뿐만 아니라 재구성된 sMVA 벡터 또는 재조합 sMVA 벡터 (도 1-4)는 단지 MVA ITR 서열의 일부만을 함유할 수 있다. 특정 실시양태에서, 하나 이상의 DNA 단편(들)은 추가로 변형되어 이중체 카피 (이중 가닥 DNA)로서 1개 단부 또는 양쪽 단부에 또는 단일 가닥 뉴클레오티드 서열로서 5' 및/또는 3' 단부에 폭스바이러스 말단 헤어핀 루프 (HL) 서열을 부가한다. 예를 들어, HL 서열은 센스 (5' → 3') 또는 안티센스 (3' → 5') 배향으로 이중 가닥 또는 단일 가닥 DNA 서열로서 합성 DNA 단편의 한쪽 단부 또는 양쪽 단부에 부가될 수 있다. 특정 실시양태에서, 하나 이상의 DNA 단편(들)은 추가로 변형되어 이중 가닥 DNA 서열로서 1개 단부 또는 양쪽 단부에 또는 단일 가닥 뉴클레오티드 서열로서 5' 및/또는 3' 단부에 폭스바이러스 콘카테머 분해 (CR: concatemeric resolution) 서열을 부가한다. CR 서열은 공통 서열 5'-T6-N7-9-T/C-A3-T/A-3'으로부터 유래된 임의의 서열에 기반할 수 있으며, 여기서 A는 아데닌이고, C는 시토신이고, G는 구아닌이고, T는 티민이고, N은 임의의 뉴클레오티드이다. 특정 실시양태에서, 2개의 CR 서열은 HL 서열의 양쪽 단부에 부가되어 CR-HL-CR 서열을 형성할 수 있다. CR-HL-CR 서열은 하나 이상의 DNA 단편(들)에 이중 가닥 DNA 서열로서 1개 단부 또는 양쪽 단부에, 또는 단일 가닥 뉴클레오티드 서열로서 5' 단부, 3' 단부, 또는 양쪽 단부에 부가될 수 있다. 다른 실시양태에서, 오직 HL 또는 CR 서열만이 이중 또는 단일 가닥 DNA 서열로서 하나 이상의 DNA 단편(들)의 1개 단부 또는 양쪽 단부에 부가된다. 특정 실시양태에서, 모든 DNA 단편은 1개 또는 양쪽 단부에 HL 또는 CR 서열 또는 이들의 조합을 함유한다. 다른 실시양태에서, 모든 DNA 단편이 HL 또는 CR 서열을 함유하는 것은 아니다. 특정 실시양태에서, 오직 DNA 단편의 하위세트 또는 하위집단만이 HL 또는 CR 서열, 또는 이들의 조합을 함유한다. ITR, HL 또는 CR 서열은 MVA (NCBI 수탁 #U94848, #AY603355), 백시니아 바이러스 (#NC_006998, #LT966077), 카멜폭스 바이러스 (#NC_003391), 우두 바이러스 (#NC_003663) 엑트로멜리아 바이러스 (#NC_004105), 원숭이 두창 바이러스 (#NC_003310), 라쿤폭스 바이러스 (#NC_027213), 스컹크폭스 바이러스 (#NC_031038), 타테라폭스 바이러스 (#NC_008291), 바리올라 바이러스 (#NC_001611, #L22579), 벨로폭스 바이러스 (#NC_031033), 카나리폭스 바이러스 (#NC_005309), 돈두 바이러스 (#NC_003389), FPV (#NC_002188, #MH734528), 점액종 바이러스 (#GQ409969), 양두 바이러스 (NC_004002), 산양두 바이러스 (#NC_004003), (오르프 바이러스 #NC_005336), 토끼 섬유종 바이러스 (#NC_001266), 이들 폭스바이러스의 임의의 균주 변이체, 또는 임의의 다른 폭스바이러스 또는 이의 균주 변이체로부터 유래될 수 있다.In certain embodiments, the one or more DNA fragment(s) further comprise one or both inverted terminal repeat (ITR) regions of a poxvirus. In certain embodiments, the sequence of the ITR may contain one or more alterations or mutations that do not affect the design scheme of the reconstituted poxvirus. In one embodiment, the one or more DNA fragments that reconstitute the poxvirus may contain only a portion of the ITR sequence. For example, sMVA fragments F1 and F3 as well as reconstituted sMVA vectors or recombinant sMVA vectors ( FIGS. 1-4 ) may contain only a portion of the MVA ITR sequence. In certain embodiments, one or more DNA fragment(s) are further modified to one or both ends as a duplex copy (double-stranded DNA) or at the 5' and/or 3' ends as a single-stranded nucleotide sequence to the poxvirus Add the terminal hairpin loop (HL) sequence. For example, an HL sequence can be added to one or both ends of a synthetic DNA fragment as a double-stranded or single-stranded DNA sequence in either sense (5' to 3') or antisense (3' to 5') orientation. In certain embodiments, one or more DNA fragment(s) are further modified to digest poxvirus concatemers at one or both ends as a double-stranded DNA sequence or at the 5' and/or 3' ends as a single-stranded nucleotide sequence. (CR: concatemeric resolution) sequence is added. The CR sequence may be based on any sequence derived from the consensus sequence 5'-T 6 -N 7-9 -T/CA 3 -T/A-3', wherein A is adenine, C is cytosine, G is guanine, T is thymine, and N is any nucleotide. In certain embodiments, two CR sequences may be added to both ends of an HL sequence to form a CR-HL-CR sequence. The CR-HL-CR sequence may be added to one or more DNA fragment(s) at one or both ends as a double-stranded DNA sequence, or at the 5' end, 3' end, or both ends as a single-stranded nucleotide sequence. . In other embodiments, only HL or CR sequences are added to one or both ends of the one or more DNA fragment(s) as double or single stranded DNA sequences. In certain embodiments, all DNA fragments contain an HL or CR sequence or a combination thereof at one or both ends. In other embodiments, not all DNA fragments contain HL or CR sequences. In certain embodiments, only a subset or subpopulation of DNA fragments contain HL or CR sequences, or a combination thereof. ITR, HL or CR sequences are MVA (NCBI accession #U94848, #AY603355), vaccinia virus (#NC_006998, #LT966077), camelpox virus (#NC_003391), vaccinia virus (#NC_003663) ectromelia virus (#NC_004105) ), monkey pox virus (#NC_003310), raccoonpox virus (#NC_027213), skunkpox virus (#NC_031038), taterapox virus (#NC_008291), variola virus (#NC_001611, #L22579), velopox virus ( #NC_031033), canarypox virus (#NC_005309), pigpox virus (#NC_003389), FPV (#NC_002188, #MH734528), myxoma virus (#GQ409969), sheeppox virus (NC_004002), goatpox virus (#NC_004003), ( Orff virus #NC_005336), rabbit fibroma virus (#NC_001266), any strain variant of these poxviruses, or any other poxvirus or strain variant thereof.
특정 실시양태에서, 본원에 사용된 HL 또는 CR 서열은 하기와 같이 개시된다:In certain embodiments, an HL or CR sequence as used herein is disclosed as follows:
MVA 콘카테머 분해 서열에 의해 플랭킹된 MVA 말단 헤어핀 루프 (HL)의 이중체 카피를 함유하는 말단 CR-HL-CR 서열의 서열 (215 bp 길이, 5' → 3') (서열식별번호(SEQ ID NO): 1) (CR 서열은 밑줄 표시되고 HL 서열은 이탤릭체이고 이중 밑줄 표시됨):The sequence of the terminal CR-HL-CR sequence (215 bp long, 5' to 3') containing a duplex copy of the MVA terminal hairpin loop (HL) flanked by the MVA concatemer cleavage sequence (SEQ ID NO: SEQ ID NO): 1) (CR sequence is underlined and HL sequence is italicized and double underlined):
콘카테머 분해 서열에 의해 플랭킹된 MVA 말단 헤어핀 루프 (HL)의 상보성 형태의 이중체 카피를 함유하는 말단 CR-HL-CR 서열의 서열 (215 bp 길이, 5' → 3') (서열식별번호: 2) (CR 서열은 밑줄 표시되고 HL 서열은 이탤릭체이고 이중 밑줄 표시됨):Sequence of the terminal CR-HL-CR sequence (215 bp long, 5' to 3') containing a duplex copy of the complementary form of the MVA terminal hairpin loop (HL) flanked by the concatemer cleavage sequence (SEQ ID NO: 3') Number: 2) (CR sequence is underlined and HL sequence is italicized and double underlined):
MVA 말단 헤어핀 루프의 서열 (HL, 165 nt 길이, 5' → 3') (서열식별번호: 3):Sequence of MVA terminal hairpin loop (HL, 165 nt length, 5' to 3') (SEQ ID NO: 3):
MVA 말단 헤어핀 루프의 상보성 형태의 서열 (HL, 165 nt 길이, 5' → 3') (서열식별번호: 4):The sequence of the complementary form of the MVA terminal hairpin loop (HL, 165 nt length, 5' to 3') (SEQ ID NO: 4):
콘카테머 분해 서열에 의해 플랭킹된 백시니아 말단 헤어핀 루프 (HL; S-형태)의 이중체 카피를 함유하는 말단 CR-HL-CR 서열의 서열 (154 bp 길이, 5' → 3') (서열식별번호: 5) (CR 서열은 밑줄 표시되고 HL 서열은 이탤릭체이고 이중 밑줄 표시됨):Sequence of the terminal CR-HL-CR sequence (154 bp long, 5' to 3') containing a duplex copy of the vaccinia terminal hairpin loop (HL; S-form) flanked by a concatemer cleavage sequence ( SEQ ID NO: 5) (CR sequence is underlined and HL sequence is italicized and double underlined):
콘카테머 분해 서열에 의해 플랭킹된 백시니아 말단 헤어핀 루프 (HL; F-형태)의 이중체 카피를 함유하는 말단 CR-HL-CR 서열의 서열 (154 bp 길이, 5' → 3') (서열식별번호: 6) (CR 서열은 밑줄 표시되고 HL 서열은 이탤릭체이고 이중 밑줄 표시됨):The sequence of the terminal CR-HL-CR sequence (154 bp long, 5' to 3') containing a duplex copy of the vaccinia terminal hairpin loop (HL; F-form) flanked by a concatemer cleavage sequence ( SEQ ID NO: 6) (CR sequence is underlined and HL sequence is italicized and double underlined):
백시니아 바이러스 말단 헤어핀 루프의 서열 1 (HL, S-형태, 104 nt 길이, 5' → 3') (서열식별번호: 7):SEQ ID NO: 1 (HL, S-form, 104 nt length, 5' to 3') of the vaccinia virus terminal hairpin loop (SEQ ID NO: 7):
백시니아 바이러스 말단 헤어핀 루프의 서열 2 (HL, F-형태, 104 nt 길이, 5' → 3') (서열식별번호: 8):SEQ ID NO: 2 (HL, F-form, 104 nt length, 5' to 3') of the vaccinia virus terminal hairpin loop (SEQ ID NO: 8):
실시예에서 헤어핀 이중체 카피의 좌측 단부에 포함된, MVA 콘카테머 분해 서열의 서열 1 (CR, 20 bp 길이, 5' → 3') (서열식별번호: 9, 센스 배향):SEQ ID NO: 1 (CR, 20 bp length, 5' to 3') of the MVA concatemer cleavage sequence, included at the left end of the hairpin duplex copy in the example (SEQ ID NO: 9, sense orientation):
실시예에서 헤어핀 이중체 카피의 우측 단부에 포함된, MVA 콘카테머 분해 서열의 서열 2 (CR, 20 bp 길이, 5' → 3') (서열식별번호: 10, 안티센스 배향):SEQ ID NO: 2 (CR, 20 bp length, 5' to 3') of the MVA concatemer cleavage sequence, included at the right end of the hairpin duplex copy in the example (SEQ ID NO: 10, antisense orientation):
실시예에서 입증된 바와 같이, 본원에 개시된 sMVA 및 rsMVA 재조합체는 앙투안 및 동료에 의해 공개된 MVA 게놈 (수탁# U94848)의 전체 ~178 kbp를 포함하는 3개의 ~60 kbp 길이의 DNA 단편의 화학적 합성에 기반하여 생성된다26. 이는 도 1에 예시된 바와 같이 내부 고유 영역 (UR) 및 ~9.6 kbp 길이의 플랭킹 역전된 말단 반복부 (ITR) 영역을 포함한다. MVA 균주 앙투안으로 본원에서 지칭되는, 앙투안 등에 의해 공개된 MVA 게놈 서열 (수탁# U94848)26은 1974로부터의 허가되고 상업적으로 이용가능한 국립보건원(National Institute of Health) 클론 1의 MVA 게놈 (MVA NIH 클론 1)과 내부 UR에서 정확히 5개의 염기가 상이하고, 이는 MVA 균주 아캠비스(Acambis) (수탁# AY603355)의 공개된 게놈과 서열에서 동일하다. sMVA 단편 1 (F1)은 MVA 게놈의 좌측 ITR 및 내부 UR의 ~50 kbp의 좌측 단부를 포함하고; sMVA 단편 2 (F2)는 MVA 게놈의 내부 UR의 ~60 kbp의 중간 부분을 함유하고; sMVA 단편 3 (F3)은 MVA 게놈의 내부 UR의 ~50 kbp의 우측 단부 및 우측 ITR을 포함한다 (도 1). sMVA F1 및 F2 뿐만 아니라 sMVA F2 및 F3은 ~3 kbp 중첩된 서열을 공유하도록 설계되어 상동성 재조합에 의한 완전한 MVA 게놈의 재구성을 허용한다 (도 1). MVA CR 서열에 의해 플랭킹된 165개-뉴클레오티드 길이의 MVA 말단 HL의 이중체 카피는 3개의 단편 각각의 양쪽 단부에 부가되어 MVA 게놈 분해 및 패키징을 촉진한다26 (도 1). 또한, SfiI 및 FseI 제한 부위가 단편이 HL 및 CR 서열과 함께 또는 없이 방출되거나 또는 선형화될 수 있는 방식으로 3개의 단편 각각의 양쪽 단부에 포함된다. 유일한 예외는 MVA 콘카테머 복제 중간체의 접합부에서 발생한 것과 동일한 배열로 단부에 융합된 F1 및 F3의 ITR에서의 HL 및 CR 서열이다26 (도 1). 도 1에 도시된 바와 같이 플랭킹 HL 및 CR 서열 뿐만 아니라 중첩된 상동성 재조합 서열을 갖는 3개의 sMVA 단편은 진스크립트 바이오테크(Genscript Biotech)에 의한 효모-기반 재조합 시스템을 사용하여 합성되고 생성되었다. 모든 3개의 sMVA 단편은 박테리아에서 낮은 카피수로 3개의 단편을 안정하게 증식시키기 위한 BAC 벡터로서 사용될 수 있는 박테리아 미니-F 레플리콘 요소를 함유하고 pCCI-브릭으로 불리는 효모 셔틀 벡터로 클로닝되었다 (도 1). sMVA 단편은 재조합 결함이 있는 DH10B 또는 EPI300 이. 콜라이 세포로 궁극적으로 클로닝되었다.As demonstrated in the examples, the sMVA and rsMVA recombinants disclosed herein are chemically synthesized from three -60 kbp long DNA fragments comprising the total 178 kbp of the MVA genome (Accession # U94848) published by Antoine and co-workers. It is generated based on synthesis 26 . It contains an internal native region (UR) and a flanking inverted terminal repeat (ITR) region of ˜9.6 kbp in length, as illustrated in FIG. 1 . The MVA genome sequence published by Antoine et al. (Accession# U94848) 26 , referred to herein as the MVA strain Antoine, is a licensed and commercially available National Institute of
특정 실시양태에서, 3개의 MVA 단편 각각의 양쪽 단부에서 플랭킹 CR 서열을 갖는 HL의 이중체 카피가 포함된다 - 이들이 콘카테머 복제 중간체에서 천연 발생하는 F1 및 F3의 ITR에서의 단부에서만 포함되는 것과는 반대이다. 이 설계는 이들 서열 요소가 폭스바이러스 DNA 복제 동안 갖는 고유한 기능에 기반한 것이다. 패키징된 폭스바이러스 게놈에서 말단 HL은 게놈 말단에서 2개의 DNA 가닥을 연속적인 폴리뉴클레오티드 쇄로 연결하며, 여기서 이들은 불완전하게 염기-쌍형성되고 AT-풍부한, 역전되고 상보성인 형태로 양쪽 단부에 존재한다26-29. 폭스바이러스 HL 서열은 다량체성 머리-꼬리 또는 머리-머리 콘카테머 복제 중간체로의 이중 가닥 DNA 게놈의 복제에 중요하며, 여기서 HL 서열은 정확한 이중체 카피로서 콘카테머 접합부에 존재한다30-32. CR 요소는 매우 보존된 폭스바이러스 분해 서열로 구성되고 패키징된 게놈에서 말단 HL에 직접 인접한 큰 ITR의 양쪽 단부에서 발견될 수 있다26,27,33,34. 콘카테머 복제 중간체에서의 폭스바이러스 CR 요소는 게놈 접합부에서 HL 이중체 카피의 한쪽 부위에 존재하고, 이들 CR/HL/CR 서열 배열은 단위-길이 게놈의 분해 및 후속 게놈 패키징에 필수적이다33-36. CR 요소에 의해 플랭킹된 HL 이중체 카피로 구성된 폭스바이러스 콘카테머 접합부를 함유하는 원형 플라스미드가 폭스바이러스 감염된 세포로 형질감염될 때, 이들은 말단 HL을 갖는 선형 미니염색체로 자발적으로 분해된다36,37. 특정 실시양태에서, 숙주 세포로 형질감염될 때, 원형화된 sMVA 단편은 기점 독립적인 방식으로 숙주 세포에서 즉시 복제할 수 있다. 폭스바이러스 감염된 세포로 형질감염된 임의의 원형 DNA 분자가 기점 독립적인 방식으로 복제되고, 이 비-특이적 서열 복제가 임의의 바이러스 DNA 단편의 삽입에 의해 증진되지 않는 것으로 보고되었다38. 다른 실시양태에서, 숙주 세포로 형질감염될 때, 원형화된 sMVA 단편은 벡터 또는 MVA 서열로 삽입된 진핵생물 또는 바이러스 복제 기점에 의해 복제될 수 있다.In certain embodiments, duplex copies of HL with flanking CR sequences at both ends of each of the three MVA fragments are included - they are included only at the ends in the ITR of F1 and F3 naturally occurring in concatemer replication intermediates Contrary to that This design is based on the unique functions these sequence elements have during poxvirus DNA replication. The terminal HL in the packaged poxvirus genome joins two DNA strands at the end of the genome into a continuous polynucleotide chain, where they are incompletely base-paired and present at both ends in an AT-rich, inverted and complementary form 26 -29 . The poxvirus HL sequence is important for replication of the double-stranded DNA genome into a multimeric head-tail or head-head concatemer replication intermediate, where the HL sequence is present at the concatemer junction as an exact duplex copy 30-32 . CR elements consist of highly conserved poxvirus degradation sequences and can be found at both ends of large ITRs directly adjacent to the terminal HL in the packaged genome 26,27,33,34 . The poxvirus CR elements in the concatemer replication intermediate are present at one site of the HL duplex copy at the genomic junction, and these CR/HL/CR sequence alignments are essential for digestion of the unit-length genome and subsequent genome packaging 33- 36 . When circular plasmids containing poxvirus concatemer junctions consisting of HL duplex copies flanked by CR elements are transfected into poxvirus infected cells, they spontaneously degrade into linear minichromosomes with terminal HL 36, 37 . In certain embodiments, when transfected into a host cell, the circularized sMVA fragment is capable of immediate replication in the host cell in an origin-independent manner. It has been reported that any circular DNA molecule transfected into poxvirus infected cells replicates in an origin-independent manner and that this non-specific sequence replication is not enhanced by insertion of any viral DNA fragment 38 . In other embodiments, when transfected into a host cell, the circularized sMVA fragment can be replicated by a eukaryotic or viral origin of replication inserted into a vector or MVA sequence.
합성 폭스바이러스 예컨대 sMVA의 개시된 구축 기술은 FPV-감염된 BHK 또는 CEF 세포로의 플랭킹 콘카테머 게놈 접합부 (CR-HL-CR) 및 중첩된 게놈 서열을 갖는 3개의 합성 MVA 단편을 함유하는 원형 플라스미드 또는 DNA 분자의 형질감염이 (1) 3개의 sMVA 단편의 전사 및 복제, (2) 플라스미드 벡터 서열로부터의 3개의 sMVA 단편의 분해, 및 (3) 전장 게놈으로의 3개의 sMVA 단편의 재조합을 촉진하여, 궁극적으로 미리 형성된 바이러스 입자 내로의 말단 HL을 갖는 벡터-무함유 게놈의 패키징을 일으키도록 HL 및 CR 서열을 포함한다 (도 1 및 2). 이들 이벤트는 FPV 감염의 결과로서 즉시 개시될 수 있거나 또는 이들은 3개의 sMVA 단편의 전사 개시 및 복제 후 순차적 과정으로 발생할 수 있다. 또 다른 실시양태에서, 3개의 sMVA 단편으로부터의 sMVA의 재구성 과정은 FPV 또는 다른 헬퍼 바이러스 없이 개시될 수 있다. 원형 플라스미드 또는 DNA 분자 사용하여 3개의 MVA 단편으로부터 sMVA를 재구성하는 이 전략에 대한 대안에서, sMVA의 재구성은 또한 도 1 및 2에 제시된 바와 같이 예를 들어 부가된 FseI 및 SfiI 제한 부위를 사용하는 선형화된 형태의 3개의 sMVA 단편에 기반한 접근법에 의해 촉진될 수 있다.The disclosed construction technique of synthetic poxviruses such as sMVA is a circular plasmid containing three synthetic MVA fragments with flanking concatemer genomic junctions (CR-HL-CR) and overlapping genomic sequences into FPV-infected BHK or CEF cells. or transfection of the DNA molecule promotes (1) transcription and replication of the three sMVA fragments, (2) digestion of the three sMVA fragments from the plasmid vector sequence, and (3) recombination of the three sMVA fragments into the full-length genome. and, ultimately, contain HL and CR sequences to result in packaging of the vector-free genome with terminal HLs into preformed viral particles ( FIGS. 1 and 2 ). These events may be initiated immediately as a result of FPV infection or they may occur in a sequential process following transcriptional initiation and replication of the three sMVA fragments. In another embodiment, the process of reconstitution of sMVA from three sMVA fragments can be initiated without FPV or other helper virus. In an alternative to this strategy of reconstituting sMVA from three MVA fragments using circular plasmids or DNA molecules, reconstitution of sMVA is also linearized using, for example, added Fsel and SfiI restriction sites as shown in Figures 1 and 2 This can be facilitated by an approach based on the three sMVA fragments in the isolated form.
3개의 MVA 단편의 원형 또는 선형화된 형태 또는 원형 및 선형화된 형태의 조합을 사용하는 지 여부와 상관없이, 단편의 단부는 HL 및 CR 서열을 함유하거나 또는 함유하지 않을 수 있다. 특정 실시양태에서, 오직 단편의 하위세트만이 HL 및 CR 서열을 함유할 수 있거나, 또는 이들은 센스 또는 안티센스 배향으로, 예를 들어 이들이 추정의 콘카테머 복제 중간체에서 천연 발생하는 F1 및 F3의 MVA 부분적인 서열에서만 존재하는 방식으로 단일 또는 이중 가닥 DNA 서열로서 단편의 오직 1개 단부 또는 2개 단부에 부가될 수 있다. 또 다른 예에서, 모든 F1 단편이 HL 및 CR 서열을 함유하는 것은 아니고; 오히려, HL 및 CR 서열을 갖거나 또는 없는 F1 단편이 구축 과정에서 혼합될 수 있다. 마찬가지로, 모든 F2 또는 F3 단편이 HL 및 CR 서열을 함유하도록 요구되는 것은 아니지만 F2 또는 F3 단편의 하위세트 또는 하위집단은 HL 및 CR 서열을 함유할 수 있다. 특정 실시양태에서, HL 및/또는 CR 서열은 또한 선형화된 형태의 3개의 단편에서 단일 또는 이중 가닥 DNA 서열로서 화학적으로 라이게이션될 수 있다.Regardless of whether using a circular or linearized form of the three MVA fragments or a combination of circular and linearized forms, the ends of the fragments may or may not contain HL and CR sequences. In certain embodiments, only a subset of the fragments may contain HL and CR sequences, or they may be in a sense or antisense orientation, e.g., the MVAs of F1 and F3 where they occur naturally in putative concatemer replication intermediates. It can be appended to only one or two ends of a fragment as a single or double-stranded DNA sequence in such a way that it is only present in partial sequence. In another example, not all F1 fragments contain HL and CR sequences; Rather, F1 fragments with or without HL and CR sequences can be mixed during construction. Likewise, a subset or subpopulation of F2 or F3 fragments may contain HL and CR sequences, although not all F2 or F3 fragments are required to contain HL and CR sequences. In certain embodiments, the HL and/or CR sequences may also be chemically ligated as single or double stranded DNA sequences in the three fragments in a linearized form.
또 다른 실시양태에서, sMVA 단편으로부터 재구성된 sMVA 바이러스는 삽입, 결실, 또는 점 돌연변이를 도입함으로써, 또는 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 이종성 DNA 서열로의 삽입에 의해 변형될 수 있다. 이들 변형 또는 항원 서열은 상동성 재조합을 매개하는 상동성 플랭크를 갖는 전달 플라스미드를 사용하는 종래의 형질감염/감염 방법에 의해 sMVA DNA 단편으로 도입될 수 있다. 특정 실시양태에서, 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 뉴클레오티드 서열은 진핵생물 또는 백시니아 발현에 코돈 최적화될 수 있다. 예를 들어, 항원, 그의 서브유닛 또는 단편은 숙주 세포에서의 전사 또는 발현의 안정성에 최적화될 수 있다. 코딩된 단백질에서 아미노산 변화를 일으키지 않는 침묵 점 돌연변이의 도입에 의한 4개의 연이어 동일한 뉴클레오티드 (예를 들어 GGGG, CCCC, TTTT, AAAA)의 변경, 또는 특정 숙주 종에 대한 코돈 사용의 적응을 포함하나, 이에 제한되지는 않는 다양한 코돈 최적화 기술이 사용될 수 있다.In another embodiment, an sMVA virus reconstituted from an sMVA fragment is modified by introducing insertions, deletions, or point mutations, or by insertion into one or more heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof. can These modifications or antigenic sequences can be introduced into the sMVA DNA fragment by conventional transfection/infection methods using transfer plasmids with homologous flanks that mediate homologous recombination. In certain embodiments, one or more nucleotide sequences encoding one or more antigens, subunits or fragments thereof may be codon optimized for eukaryotic or vaccinia expression. For example, an antigen, subunit or fragment thereof can be optimized for stability of transcription or expression in a host cell. alteration of four consecutive identical nucleotides (e.g. GGGG, CCCC, TTTT, AAAA) by introduction of silent point mutations that do not result in amino acid changes in the encoded protein, or adaptation of codon usage to a particular host species, Various codon optimization techniques may be used, but not limited thereto.
또 다른 실시양태에서, 숙주 세포 예컨대 BHK 또는 CEF 세포에서의 sMVA 단편으로부터 재구성된 sMVA 바이러스는 전장 sMVA 게놈을 함유하는 sMVA 박테리아 인공 염색체 (BAC)를 생성하는 데 사용될 수 있다. BAC 벡터 서열은 상동성 재조합을 매개하는 플랭킹 상동성 서열을 갖는 BAC 서열을 함유하는 전달 구축물에 의해 sMVA 게놈으로 삽입될 수 있다. 삽입된 BAC 서열을 갖는 원형 복제 중간체는 숙주 세포 예컨대 BHK 또는 CEF 세포로부터 단리되고 전기천공 또는 화학적 형질전환에 의해 큰 DNA 구축물의 안정한 증식을 허용하는 이. 콜라이 세포, 예컨대 DH10B 또는 EPI300으로 전달될 수 있다. 또 다른 실시양태에서, sMVA BAC는 GS1783 이. 콜라이 세포로 전달되고 레드(Red)-재조합 기술 예컨대 앙 파상(En passant) 돌연변이유발에 의해 조작될 수 있다.In another embodiment, a sMVA virus reconstituted from an sMVA fragment in a host cell such as a BHK or CEF cell can be used to generate an sMVA bacterial artificial chromosome (BAC) containing the full-length sMVA genome. The BAC vector sequence can be inserted into the sMVA genome by a transfer construct containing a BAC sequence with flanking homologous sequences that mediate homologous recombination. Circular replication intermediates with inserted BAC sequences are isolated from host cells such as BHK or CEF cells and allow stable propagation of large DNA constructs by electroporation or chemical transformation. coli cells, such as DH10B or EPI300. In another embodiment, the sMVA BAC is GS1783 E. It can be transferred into E. coli cells and manipulated by Red-recombinant techniques such as En passant mutagenesis.
또 다른 실시양태에서, sMVA 단편은 시험관내 라이게이션 방법에 의해 또는 다른 시험관내 DNA 조립 방법 예컨대 깁슨(Gibson) 또는 골든 게이트(Golden Gate) 조립에 의해 완전한 또는 전장 sMVA 게놈을 재구성하는 데 사용될 수 있다.In another embodiment, the sMVA fragment can be used to reconstruct the complete or full-length sMVA genome by in vitro ligation methods or by other in vitro DNA assembly methods such as Gibson or Golden Gate assembly. .
항원 또는 다른 이종성 유전자 서열의 발현Expression of antigens or other heterologous gene sequences
본원에 개시된 기술은 재구성 시, 항원, 그의 서브유닛 또는 단편을 발현하는 합성 폭스바이러스가 수득되도록, 형질감염 전에 하나 이상의 천연적으로 유래된 또는 화학적으로 합성된 DNA 단편(들)으로 다양한 항원, 그의 서브유닛 또는 단편, 또는 다른 이종성 DNA 서열을 삽입하는 유연성을 갖는다. 이들 항원, 그의 서브유닛 또는 단편은 바이러스 예컨대 시토메갈로바이러스 (CMV), 엡스타인-바 바이러(Epstein-Barr virus) (EBV), 카포시-육종-연관 헤르페스바이러스(Kaposi-Sarcoma-associated herpesvirus) (KSHV), 다른 헤르페스바이러스, 지카 바이러스(Zika virus), 라싸 바이러스(Lassa virus), C형 간염 바이러스(Hepatitis C virus) (HCV), 간염 (HBV), 코로나바이러스(Coronavirus) (예컨대 2019-nCoV, SARS, MERS), 인플루엔자(Influenza), 또는 임의의 다른 바이러스, 박테리아, 또는 다른 형태의 감염성 병원체로부터 유래되거나 또는 그에 기반할 수 있다. 항원 서열은 또한 암-연관 단백질 (예를 들어, p53, 망막모세포종, 신생항원)으로부터 유래되거나 또는 그에 기반할 수 있다. 마찬가지로, 다른 이종성 유전자 서열이 천연적으로 유래된 또는 화학적으로 합성된 폭스바이러스 DNA 단편(들)으로 삽입될 수 있다. 이러한 이종성 유전자 서열은 형광 마커, RNA 예컨대 RNAi, shRNA, LNCRNA, miRNA, 등의 cDNA 카피, 인터페론, 시토카인, 항체 또는 그의 단편, 또는 원핵 또는 진핵 세포에서 발현되는 다른 단백질을 포함하나, 이에 제한되지는 않는다. 특정 실시양태에서, 항원 서열 또는 이종성 유전자 서열은 폭스바이러스 단편이 숙주 세포로 형질감염될 때 항원 서열 또는 이종성 유전자 서열이 발현되도록 상류 천연 또는 합성 폭스바이러스 프로모터 (pSyn, P11, H5, mH5, P28, ATI, pHyb, p7.5) 및 하류 전사 종결 신호 (TTTTTAT)와 함께 sMVA 단편으로 삽입될 수 있다.The techniques disclosed herein provide a method for reconstituting a variety of antigens, its subunits or fragments, into one or more naturally derived or chemically synthesized DNA fragment(s) prior to transfection, such that upon reconstitution, a synthetic poxvirus expressing the antigen, subunits or fragments thereof is obtained. It has the flexibility to insert subunits or fragments, or other heterologous DNA sequences. These antigens, subunits or fragments thereof, are viruses such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), Kaposi-Sarcoma-associated herpesvirus (KSHV). ), other herpesviruses, Zika virus, Lassa virus, Hepatitis C virus (HCV), hepatitis (HBV), Coronavirus (such as 2019-nCoV, SARS) , MERS), influenza, or any other virus, bacterium, or other form of an infectious pathogen. The antigenic sequence may also be derived from or based on a cancer-associated protein (eg, p53, retinoblastoma, neoantigen). Likewise, other heterologous gene sequences can be inserted into the naturally derived or chemically synthesized poxvirus DNA fragment(s). Such heterologous gene sequences include, but are not limited to, fluorescent markers, cDNA copies of RNA such as RNAi, shRNA, LNCRNA, miRNA, etc., interferons, cytokines, antibodies or fragments thereof, or other proteins expressed in prokaryotic or eukaryotic cells. does not In certain embodiments, the antigenic sequence or heterologous gene sequence is selected from an upstream native or synthetic poxvirus promoter (pSyn, P11, H5, mH5, P28, ATI, pHyb, p7.5) and downstream transcription termination signal (TTTTTAT) can be inserted into the sMVA fragment.
항원, 그의 서브유닛 또는 단편, 또는 다른 이종성 유전자 서열의 DNA 서열은 하나 이상의 DNA 단편(들) 내 하나 이상의 폭스바이러스 삽입 부위로 삽입될 수 있다. 예로서 sMVA를 사용하여, 1개의 항원 또는 그의 단편의 DNA 서열이 숙주 세포의 형질감염 전에 1개의 sMVA DNA 단편, 예를 들어, sMVA F2 상에 위치한 단일 MVA 삽입 부위에 삽입될 수 있다 (도 3). 또 다른 예에서, 2개 이상의 항원 또는 그의 단편의 DNA 서열이 숙주 세포의 형질감염 전에 1개의 DNA 단편, 예를 들어, sMVA F2 상에 위치한 단일 MVA 삽입 부위로 삽입될 수 있다. 이들 항원 DNA 서열은 단일 프로모터 또는 2개 이상의 프로모터의 제어 하에 있을 수 있다. 마찬가지로, 항원 DNA 서열은 동일한 전사 종결 신호를 공유하거나 또는 상이한 전사 종결 신호를 가질 수 있다. 2개 이상의 항원을 코딩하는 뉴클레오티드 서열은 또한 항원이 번역 후 가공되고 자기-조립되어 다중-성분 항원 복합체를 형성하도록 리보솜 스킵핑을 매개하는 피코르나바이러스(picornavirus)의 2A 서열 (P2A, T2A, F2A, 등)에 의해 또는 내부 리보솜 진입 부위 (IRES)에 의해 연결될 수 있다.The DNA sequence of the antigen, subunit or fragment thereof, or other heterologous gene sequence may be inserted into one or more poxvirus insertion sites in one or more DNA fragment(s). Using sMVA as an example, the DNA sequence of one antigen or fragment thereof can be inserted into a single MVA insertion site located on one sMVA DNA fragment, eg, sMVA F2, prior to transfection of the host cell ( FIG. 3 ). ). In another example, the DNA sequences of two or more antigens or fragments thereof can be inserted into a single MVA insertion site located on one DNA fragment, eg, sMVA F2, prior to transfection of the host cell. These antigenic DNA sequences may be under the control of a single promoter or two or more promoters. Likewise, antigenic DNA sequences may share the same transcription termination signal or have different transcription termination signals. Nucleotide sequences encoding two or more antigens may also include the 2A sequence of picornaviruses (P2A, T2A, P2A, T2A, F2A, etc.) or by an internal ribosome entry site (IRES).
특정 실시양태에서, 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열, 또는 다른 이종성 DNA 서열은 하나 이상의 천연적으로 유래된 또는 화학적으로 합성된 폭스바이러스 DNA 단편이 숙주 세포로 형질감염될 때, 폭스바이러스 단백질의 C-말단, N-말단, 또는 임의의 내부 위치에 부가된 하나 이상의 항원, 그의 서브유닛 또는 단편, 또는 다른 이종성 단백질 서열과 함께 폭스바이러스 단백질로 구성된 하나 이상의 융합 단백질이 발현되도록 하나 이상의 필수 또는 비필수 폭스바이러스 오픈 리딩 프레임 (ORF)의 5' 단부, 3' 단부, 또는 임의의 내부 위치에서 프레임에 삽입된다. 일부 실시양태에서, 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열, 또는 다른 이종성 DNA 서열은 폭스바이러스 단백질의 C-말단, N-말단, 또는 임의의 내부 위치에 부가된 하나 이상의 항원, 그의 서브유닛 또는 단편, 또는 다른 이종성 단백질 서열과 함께 폭스바이러스 단백질로 구성된 발현된 하나 이상의 융합 단백질이 리보솜 스킵핑 메커니즘에 의해 2A 링커 서열에서 개별 성분으로 가공되도록 ("절단되도록") 피코르나바이러스의 2A 코딩 서열 (P2A, F2A, T2A 등)에 의해 하나 이상의 폭스바이러스 ORF에 연결된다. 다른 실시양태에서, 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열, 또는 다른 이종성 DNA 서열은 하나 이상의 천연적으로 유래된 또는 화학적으로 합성된 폭스바이러스 DNA 단편이 숙주 세포로 형질감염될 때, 하나 이상의 폭스바이러스 단백질 및 하나 이상의 항원, 그의 서브유닛 또는 단편, 또는 다른 이종성 단백질 서열이 발현 구축물 내 각각의 ORF의 5' 단부에서 다수의 번역 개시 부위를 갖는 키메라 폴리시스트론 발현 구축물을 통해 동시에 발현되도록 내부 리보솜 진입 부위 서열에 의해 하나 이상의 필수 또는 비필수 폭스바이러스 ORF에 연결된다.In certain embodiments, one or more DNA sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA sequences are transfected into a host cell by one or more naturally derived or chemically synthesized poxvirus DNA fragments. one or more fusion proteins consisting of a poxvirus protein with one or more antigens, subunits or fragments thereof, or other heterologous protein sequences added at the C-terminus, N-terminus, or any internal position of the poxvirus protein when inserted in frame at the 5' end, 3' end, or any internal location of one or more essential or non-essential poxvirus open reading frames (ORFs) for expression. In some embodiments, one or more DNA sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA sequences are added at the C-terminus, N-terminus, or any internal location of the poxvirus protein to one or more Picor such that expressed one or more fusion proteins consisting of a poxvirus protein together with an antigen, subunit or fragment thereof, or other heterologous protein sequence are processed ("cleaved") into individual components in the 2A linker sequence by a ribosome skipping mechanism. linked to one or more poxvirus ORFs by a navirus 2A coding sequence (P2A, F2A, T2A, etc.). In other embodiments, one or more DNA sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA sequences are transfected into a host cell by one or more naturally derived or chemically synthesized poxvirus DNA fragments. chimeric polycistronic expression constructs wherein one or more poxvirus proteins and one or more antigens, subunits or fragments thereof, or other heterologous protein sequences have multiple translation initiation sites at the 5' end of each ORF in the expression construct linked to one or more essential or non-essential poxvirus ORFs by an internal ribosome entry site sequence for simultaneous expression via
특정 실시양태에서, 2개 이상의 항원, 그의 서브유닛 또는 단편의 DNA 서열 또는 다른 이종성 유전자 서열은 동일한 sMVA 단편 상에 또는 상이한 sMVA 단편 상에 위치할 수 있는 2개 이상의 MVA 삽입 부위로 삽입될 수 있다. 예를 들어, 2개 이상의 항원, 그의 서브유닛 또는 단편의 DNA 서열은 둘 다 sMVA F1 상에 위치한 2개의 상이한 MVA 삽입 부위에 삽입될 수 있다. 또 다른 예에서, 2개 이상의 항원, 그의 서브유닛 또는 단편의 DNA 서열은 하나는 sMVA F1 상에 위치하고 다른 하나는 sMVA F2 상에 위치한 2개의 상이한 MVA 삽입 부위로 삽입될 수 있다 (도 4). 상이한 DNA 단편에 동일한 항원, 그의 서브유닛 또는 단편의 DNA 서열이 삽입될 수 있는 것으로 이해된다. 대안적으로, 상이한 sMVA 단편에 형질감염 후 재구성 시, 합성 MVA에 의해 발현된 상이한 항원, 그의 서브유닛 또는 단편이 바이러스 입자, 바이러스 복합체, 또는 그의 서브유닛 또는 단편을 포함하는 완전한 항원으로 자기-가공되고 자기-조립되도록 상이한 항원, 그의 서브유닛 또는 단편의 DNA 서열이 삽입될 수 있다.In certain embodiments, the DNA sequences or other heterologous gene sequences of two or more antigens, subunits or fragments thereof may be inserted into two or more MVA insertion sites that may be located on the same sMVA fragment or on different sMVA fragments. . For example, the DNA sequences of two or more antigens, subunits or fragments thereof can both be inserted at two different MVA insertion sites located on sMVA F1. In another example, the DNA sequences of two or more antigens, subunits or fragments thereof can be inserted into two different MVA insertion sites, one located on sMVA F1 and the other located on sMVA F2 ( FIG. 4 ). It is understood that the DNA sequences of the same antigen, subunits or fragments thereof may be inserted into different DNA fragments. Alternatively, upon reconstitution after transfection with different sMVA fragments, the different antigens, subunits or fragments thereof, expressed by synthetic MVA self-process into complete antigens comprising viral particles, viral complexes, or subunits or fragments thereof. The DNA sequences of different antigens, subunits or fragments thereof can be inserted so that they become self-assembled and self-assemble.
실시예에서 입증된 바와 같이, BAC 기술을 사용하여 재조합 MVA 벡터를 생성하는 이전에 확립된 방법16,18,24,25이 3개의 sMVA 단편을 사용하여 rsMVA 재조합체를 생성하기 위해 조정되었다. 3개의 sMVA 단편이 미니-F 레플리콘을 갖는 BAC 벡터로 클로닝되었기 때문에 이들은 박테리아에서 안정하게 증식될 수 있고, 결과적으로, 이들은 매우 효율적인 재조합 방법 예컨대 앙 파상 돌연변이유발 또는 다른 이. 콜라이-기반 조작 절차에 의해 조작될 수 있다39,40. 이들 방법을 사용하여, 상류 백시니아 바이러스 프로모터 및 하류 전사 종결 신호와 함께 천연적으로 유래된 또는 합성 이종성 항원 서열은 사실상 모든 MVA 게놈 위치로 병렬, 연속적, 또는 반복된 방식으로 3개의 sMVA 단편 중 단지 1개, 2개, 또는 모두로 삽입될 수 있다 (도 3 및 4). 이들 삽입 부위는 통상적으로 사용되는 삽입 부위 예컨대 MVA 결실 2 (Del2) 부위, 오픈 리딩 프레임 (ORF) 44L과 45L 사이의 유전자간 영역 (IGR) (IGR44/45), ORF 69R과 70L 사이의 IGR (IGR69/70), 64L과 65L 사이의 IGR (IGR64/65), 티미딘 키나제 (TK) 유전자 삽입 부위, 또는 MVA 결실 3 (Del3) 부위 (도 1), 또는 임의의 다른 MVA 결실 부위, 유전자간 영역, 또는 유전자 삽입 부위를 포함할 수 있다 (ORF 번호는 MVA 균주 앙투안 (수탁# U94848)에 기반함). 이들 방법은 또한 하나 이상의 sMVA 단편의 1개 또는 다수의 위치에서 1개 또는 다수의 점 돌연변이, 삽입, 또는 결실을 생성하는 데 사용될 수 있다. 이어서, 변형된 sMVA 단편은 이. 콜라이로부터 단리되고 다양한 형질감염 방법에 의해 원형 또는 선형화된 DNA 분자로서 헬퍼 바이러스로 감염된 BHK 또는 CEF 세포로 공동-전달되어 단일, 이중, 또는 다중 항원 삽입 또는 게놈 변경을 갖는 rsMVA의 재구성을 개시할 수 있다 (도 3 및 4). 특정 실시양태에서, rsMVA 재구성은 헬퍼 바이러스의 첨가 없이 개시될 수 있다. 특정 실시양태에서, 3개의 sMVA 단편은 또한 시험관내 라이게이션 방법에 의해 단일 또는 다중 항원 삽입 또는 게놈 변경을 갖는 sMVA를 생성하는 데 사용될 수 있다. 특정 실시양태에서, 하나 이상의 항원, 그의 서브유닛 또는 단편은 sMVA 단편의 하나 이상의 MVA 삽입 부위로 삽입될 수 있다. 특정 실시양태에서, 오직 1개의 sMVA 단편에 하나 이상의 항원 또는 그의 단편이 삽입된다 (도 3). 특정 실시양태에서, 2개 이상의 sMVA 단편에 하나 이상의 항원 또는 그의 단편이 삽입된다 (도 4). 특정 실시양태에서, 모든 sMVA 단편에 하나 이상의 항원, 그의 서브유닛 또는 단편이 삽입된다 (도 4). 2개 이상의 sMVA 단편에 항원, 그의 서브유닛 또는 단편이 삽입될 때, 항원, 그의 서브유닛 또는 단편은 상이한 sMVA 단편에 대해 동일하거나 또는 상이할 수 있다. 예를 들어, sMVA F1에 하나의 유형의 항원 또는 그의 단편이 삽입될 수 있고, sMVA F2에 상이한 유형의 항원 또는 그의 단편이 삽입될 수 있다. 대안적으로, sMVA F1 및 F2에 동일한 유형의 항원 또는 그의 단편이 삽입될 수 있고 sMVA F3에 동일한 유형의 항원 또는 그의 단편 또는 상이한 유형의 항원, 그의 서브유닛 또는 단편이 삽입될 수 있다.As demonstrated in the Examples, previously established methods 16,18,24,25 for generating recombinant MVA vectors using BAC technology were adapted to generate rsMVA recombinants using three sMVA fragments. Since the three sMVA fragments were cloned into a BAC vector with a mini-F replicon, they can be stably propagated in bacteria, and as a result, they are highly efficient recombinant methods such as enzymatic mutagenesis or other E. coli. can be manipulated by E. coli-based manipulation procedures 39,40 . Using these methods, a naturally derived or synthetic heterologous antigen sequence, along with an upstream vaccinia virus promoter and a downstream transcription termination signal, can be obtained from only one of three sMVA fragments in a parallel, contiguous, or repeated fashion to virtually every MVA genomic location. One, two, or all can be inserted ( FIGS. 3 and 4 ). These insertion sites are commonly used insertion sites such as MVA deletion 2 (Del2) site, open reading frame (ORF) intergenic region (IGR) between 44L and 45L (IGR44/45), ORF IGR between 69R and 70L ( IGR69/70), an IGR between 64L and 65L (IGR64/65), a thymidine kinase (TK) gene insertion site, or an MVA deletion 3 (Del3) site ( FIG. 1 ), or any other MVA deletion site, intergenic region, or gene insertion site (ORF number is based on MVA strain Antoine (Accession# U94848)). These methods can also be used to generate one or multiple point mutations, insertions, or deletions at one or multiple positions of one or more sMVA fragments. Then, the modified sMVA fragment was produced in E. E. coli isolated and co-transferred into BHK or CEF cells infected with helper viruses as circular or linearized DNA molecules by various transfection methods to initiate reconstitution of rsMVA with single, double, or multiple antigen insertions or genomic alterations. There are (Figures 3 and 4). In certain embodiments, rsMVA reconstitution may be initiated without the addition of a helper virus. In certain embodiments, three sMVA fragments can also be used to generate sMVAs with single or multiple antigen insertions or genomic alterations by in vitro ligation methods. In certain embodiments, one or more antigens, subunits or fragments thereof may be inserted into one or more MVA insertion sites of an sMVA fragment. In certain embodiments, one or more antigens or fragments thereof are inserted into only one sMVA fragment ( FIG. 3 ). In certain embodiments, one or more antigens or fragments thereof are inserted into two or more sMVA fragments ( FIG. 4 ). In certain embodiments, one or more antigens, subunits or fragments thereof are inserted into all sMVA fragments ( FIG. 4 ). When an antigen, subunit or fragment thereof is inserted into two or more sMVA fragments, the antigen, subunit or fragment thereof may be the same or different for different sMVA fragments. For example, one type of antigen or fragment thereof may be inserted into sMVA F1, and a different type of antigen or fragment thereof may be inserted into sMVA F2. Alternatively, antigens of the same type or fragments thereof may be inserted into sMVA F1 and F2 and antigens of the same type or fragments thereof or different types of antigens, subunits or fragments thereof may be inserted into sMVA F3.
본원에 개시된 기술에 의해 생산된 폭스바이러스 벡터는, 예를 들어, 다중-항원 백신 벡터를 생성하여 다양한 상태 예컨대 바이러스 감염 및 암에 대한 다기능성 체액성 및 세포성 면역 반응을 자극하는 데 사용될 수 있다. 예로서, 3개의 sMVA 단편 F1-F3에 기반한 개시된 기술은 다중-항원 rsMVA 백신 벡터를 생성하여 인간 시토메갈로바이러스 (HCMV)에 대한 다기능성 체액성 및 세포성 면역 반응을 자극하는 데 사용될 수 있다. 이는 HCMV 오량체 복합체 (PC)의 5개의 서브유닛, 당단백질 B (gB), 인단백질 65 (pp65), 및 극초기 1 및 2 단백질 (IE1 및 IE2)에 기반한 면역우세 항원 서열을 포함할 수 있다. 항원 서열은 개별적으로 또는 2A-연결된 폴리시스트론 발현 구축물로 조합되어 통상적으로 사용되는 상이한 MVA 삽입 부위 (Del2, Del3, IGR44/45, IGR69/70, IGR64/65)에서 sMVA 단편으로 삽입되어 도 6 및 도 10에 예시된 바와 같이 5개, 6개, 7개, 8개, 또는 9개의 HCMV 항원을 발현하는 rsMVA 백신 벡터를 생성할 수 있다. 단일 HCMV 항원만을 또는 상기 언급된 9개의 HCMV 항원의 임의의 다른 개수 또는 조합을 발현하는 rsMVA 벡터가 또한 생성될 수 있다. 모든 항원 서열 또는 발현 구축물은 상류 mH5 프로모터 및 하류 전사 종결 신호와 함께 삽입될 수 있다. 이들 벡터는 동물 모델 또는 인간에서 HCMV에 대한 면역 반응을 자극하는 데 사용될 수 있다.The poxvirus vectors produced by the techniques disclosed herein can be used, for example, to generate multi-antigen vaccine vectors to stimulate multifunctional humoral and cellular immune responses against a variety of conditions such as viral infection and cancer. . As an example, the disclosed technology based on three sMVA fragments F1-F3 can be used to generate multi-antigen rsMVA vaccine vectors to stimulate multifunctional humoral and cellular immune responses against human cytomegalovirus (HCMV). It may contain immunodominant antigen sequences based on the five subunits of the HCMV pentameric complex (PC), glycoprotein B (gB), phosphoprotein 65 (pp65), and very early 1 and 2 proteins (IE1 and IE2). have. Antigen sequences were inserted into sMVA fragments either individually or in combination with 2A-linked polycistronic expression constructs at different commonly used MVA insertion sites (Del2, Del3, IGR44/45, IGR69/70, IGR64/65), Figure 6 and rsMVA vaccine vectors expressing 5, 6, 7, 8, or 9 HCMV antigens as illustrated in FIG. 10 . rsMVA vectors expressing only a single HCMV antigen or any other number or combination of the nine HCMV antigens mentioned above can also be generated. Any antigen sequence or expression construct can be inserted with an upstream mH5 promoter and a downstream transcription termination signal. These vectors can be used to stimulate an immune response to HCMV in animal models or humans.
발현 시스템 및 백신Expression Systems and Vaccines
본원에 기재된 실시양태에 따라, MVA 발현 시스템이 본원에 제공된다. 특정 실시양태에서, 발현 시스템은 하나 이상의 목적하는 항원, 그의 서브유닛 또는 단편 또는 다른 이종성 단백질 서열을 발현할 수 있다.In accordance with embodiments described herein, an MVA expression system is provided herein. In certain embodiments, the expression system is capable of expressing one or more desired antigens, subunits or fragments thereof, or other heterologous protein sequences.
상기 기재된 바와 같이, 하나 이상의 sMVA 단편에 재구성된 sMVA가 항원, 서브유닛 및 그의 단편을 동시에 발현하도록 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 DNA 서열이 삽입될 수 있다.As described above, a DNA sequence encoding one or more antigens, subunits or fragments thereof may be inserted into one or more sMVA fragments such that the reconstituted sMVA simultaneously expresses the antigen, subunits and fragments thereof.
특정 실시양태에서, sMVA 단편으로 삽입된 항원 DNA 서열은 천연 DNA 서열에 기반하거나 또는 화학적 합성으로부터의 것일 수 있다. 다른 실시양태에서, 항원 DNA 서열은 발현 시스템 내 발현 및 안정성에 최적화될 수 있다.In certain embodiments, the antigen DNA sequence inserted into the sMVA fragment may be based on a native DNA sequence or may be from chemical synthesis. In other embodiments, antigenic DNA sequences may be optimized for expression and stability in expression systems.
본원에 기재된 sMVA는 sMVA에 의해 발현되는 항원에 따라, 바이러스 감염을 치료하거나 또는 예방하거나 또는 암을 치료하는 방법에 사용될 수 있는 백신 조성물의 일부일 수 있다. 본원에 기재된 바와 같은 백신 조성물은 치료 유효량의 본원에 기재된 바와 같은 sMVA를 포함할 수 있고, 표준 방법에 따른 제약상 허용되는 담체를 추가로 포함한다. 허용되는 담체의 예는 생리학상 허용되는 용액, 예컨대 멸균 염수 및 멸균 완충 염수를 포함한다.The sMVA described herein can be part of a vaccine composition that can be used in a method of treating or preventing a viral infection or treating cancer, depending on the antigen expressed by the sMVA. A vaccine composition as described herein may comprise a therapeutically effective amount of an sMVA as described herein, further comprising a pharmaceutically acceptable carrier according to standard methods. Examples of acceptable carriers include physiologically acceptable solutions such as sterile saline and sterile buffered saline.
일부 실시양태에서, 백신 또는 제약 조성물은 제약 유효량의 아주반트와 조합되어 사용되어 예방적 또는 치료적 효과를 증진시킬 수 있다. 그 자체의 어떠한 특이적 항원 효과를 갖지 않으면서 면역계를 자극하고 백신에 대한 반응을 증가시킬 수 있는 임의의 면역 아주반트가 아주반트로서 사용될 수 있다. 많은 면역 아주반트는 병원체-연관 분자 패턴 (PAMP)으로 공지된 진화론적으로 보존된 분자를 모방하고 톨-유사 수용체 (TLR)로 공지된 면역 수용체의 세트에 의해 인식된다. 본원에 기재된 실시양태에 따라 사용될 수 있는 아주반트의 예는 프로인트(Freund) 완전 아주반트, 프로인트 불완전 아주반트, 이중 가닥 RNA (TLR3 리간드), LPS, LPS 유사체 예컨대 모노포스포릴 지질 A (MPL) (TLR4 리간드), 플라젤린 (TLR5 리간드), 지질단백질, 지질펩티드, 단일 가닥 RNA, 단일 가닥 DNA, 이미다조퀴놀린 유사체 (TLR7 및 TLR8 리간드), CpG DNA (TLR9 리간드), 리비(Ribi) 아주반트 (모노포스포릴-지질 A/트레할로스 디코리노이콜레이트), 당지질 (α-GalCer 유사체), 비메틸화된 CpG 섬, 오일 에멀젼, 리포솜, 비로솜, 사포닌 (사포닌의 활성 분획, 예컨대 QS21), 무라밀 디펩티드, 알룸, 수산화알루미늄, 스쿠알렌, BCG, 시토카인 예컨대 GM-CSF 및 IL-12, 케모카인, 예컨대 MIP 1-α 및 RANTES, 활성화 세포 표면 리간드 예컨대 CD40L, N-아세틸무라민-L-알라닐-D-이소글루타민 (MDP), 및 티모신 α1을 포함한다. 사용되는 아주반트의 양은 이러한 유형의 백신의 투여 후 인간 또는 동물에서 면역 반응의 일부로서 발현될 수 있는 증상, 예컨대 피부의 연화, 통증, 홍반, 열, 두통, 및 근육 통증의 정도에 따라 적합하게 선택될 수 있다.In some embodiments, a vaccine or pharmaceutical composition may be used in combination with a pharmaceutically effective amount of an adjuvant to enhance the prophylactic or therapeutic effect. Any immune adjuvant capable of stimulating the immune system and increasing the response to a vaccine without itself having any specific antigenic effect can be used as an adjuvant. Many immune adjuvants mimic evolutionarily conserved molecules known as pathogen-associated molecular patterns (PAMPs) and are recognized by a set of immune receptors known as Toll-like receptors (TLRs). Examples of adjuvants that may be used in accordance with embodiments described herein include Freund's complete adjuvant, Freund's incomplete adjuvant, double stranded RNA (TLR3 ligand), LPS, LPS analogs such as monophosphoryl lipid A (MPL). ) (TLR4 ligand), flagellin (TLR5 ligand), lipoproteins, lipopeptides, single-stranded RNA, single-stranded DNA, imidazoquinoline analogs (TLR7 and TLR8 ligand), CpG DNA (TLR9 ligand), Ribi jujube Vant (monophosphoryl-lipid A/trehalose dicorinoicolate), glycolipid (α-GalCer analog), unmethylated CpG island, oil emulsion, liposome, virosome, saponin (active fraction of saponin, such as QS21), muramyl dipeptides, alum, aluminum hydroxide, squalene, BCG, cytokines such as GM-CSF and IL-12, chemokines such as MIP 1-α and RANTES, activating cell surface ligands such as CD40L, N-acetylmuramine-L-alanyl- D-isoglutamine (MDP), and thymosin α1. The amount of adjuvant used will suitably depend on the severity of the symptoms that may develop as part of the immune response in humans or animals after administration of this type of vaccine, such as softening of the skin, pain, erythema, fever, headache, and muscle pain. can be selected.
추가 실시양태에서, 상기 논의된 바와 같은 본 발명의 백신과 함께 다양한 다른 아주반트, 약물 또는 첨가제의 사용은 백신 또는 제약 조성물의 투여에 의해 달성되는 치료적 효과를 증진시킬 수 있다. 제약상 허용되는 담체는 미량의 첨가제, 예컨대 등장성 및 화학적 안정성을 증진시키는 물질을 함유할 수 있다. 이러한 첨가제는 사용되는 투여량 및 농도에서 인간 또는 다른 포유류 대상체에게 비독성이어야 하고, 그의 예는 완충제 예컨대 인산, 시트르산, 숙신산, 아세트산, 및 다른 유기 산, 및 그의 염; 항산화제 예컨대 아스코르브산; 저분자량 (예를 들어, 약 10개 잔기 미만) 폴리펩티드 (예를 들어, 폴리아르기닌 및 트리펩티드) 단백질 (예를 들어, 혈청 알부민, 젤라틴, 및 이뮤노글로불린); 아미노산 (예를 들어, 글리신, 글루탐산, 아스파르트산, 및 아르기닌); 단당류, 이당류, 및 다른 탄수화물 (예를 들어, 셀룰로스 및 그의 유도체, 글루코스, 만노스, 및 덱스트린), 킬레이트제 (예를 들어, EDTA); 당 알콜 (예를 들어, 만니톨 및 소르비톨); 반대이온 (예를 들어, 나트륨); 비이온성 계면활성제 (예를 들어, 폴리소르베이트 및 폴록사머); 항생제; 및 PEG를 포함한다.In a further embodiment, the use of various other adjuvants, drugs or additives in conjunction with a vaccine of the invention as discussed above may enhance the therapeutic effect achieved by administration of the vaccine or pharmaceutical composition. Pharmaceutically acceptable carriers may contain minor amounts of additives, such as substances that enhance isotonicity and chemical stability. Such additives must be nontoxic to human or other mammalian subjects at the dosages and concentrations employed, examples of which include buffers such as phosphoric acid, citric acid, succinic acid, acetic acid, and other organic acids, and salts thereof; antioxidants such as ascorbic acid; low molecular weight (eg, less than about 10 residues) polypeptides (eg, polyarginine and tripeptides) proteins (eg, serum albumin, gelatin, and immunoglobulins); amino acids (eg, glycine, glutamic acid, aspartic acid, and arginine); monosaccharides, disaccharides, and other carbohydrates (eg, cellulose and its derivatives, glucose, mannose, and dextrins), chelating agents (eg, EDTA); sugar alcohols (eg, mannitol and sorbitol); counterions (eg, sodium); nonionic surfactants (eg, polysorbates and poloxamers); Antibiotic; and PEG.
본원에 기재된 sMVA를 함유하는 백신 또는 제약 조성물은 단위 또는 다중 용량 용기 예컨대 밀봉된 앰플 또는 바이알에 수용액 또는 동결건조된 제품으로서 저장될 수 있다.Vaccines or pharmaceutical compositions containing sMVA described herein may be stored as aqueous solutions or lyophilized products in unit or multi-dose containers such as sealed ampoules or vials.
바이러스 감염 또는 암의 예방 또는 치료Prevention or treatment of viral infection or cancer
삽입된 항원, 그의 서브유닛 또는 단편, 또는 다른 이종성 서열과 함께 또는 없이 하나 이상의 천연적으로 유래된 또는 화학적으로 합성된 DNA 단편(들)으로부터 재구성된 폭스바이러스는 다양한 바이러스 감염 또는 암을 예방하거나 또는 치료하기 위한 백신 조성물로서 사용될 수 있다. 관련 기술분야의 통상의 기술자는 예방되거나 또는 치료될 상태 또는 질환을 위한 특정한 바이러스 또는 암 항원을 선택하는 방법을 알 것이다. 이는 면역 반응을 끌어낼 수 있는 임의의 감염성 질환 또는 암 항원, 예컨대 바이러스 외피 당단백질 또는 당단백질 복합체, 면역우세 T 세포 항원, 또는 돌연변이된 암 신생항원을 포함할 수 있으나, 이에 제한되지는 않는다. 이들 항원 서열 또는 그의 일부는 바이러스 예컨대 CMV, EBV, KSHV, 다른 헤르페스바이러스, 지카 바이러스, 라싸 바이러스, HCV, HBV, 코로나바이러스, 인플루엔자, 또는 임의의 다른 바이러스, 박테리아, 또는 다른 형태의 감염성 병원체로부터 유래되거나 또는 그에 기반할 수 있다.A poxvirus reconstituted from one or more naturally derived or chemically synthesized DNA fragment(s) with or without inserted antigen, subunits or fragments thereof, or other heterologous sequences, can prevent various viral infections or cancers or It can be used as a vaccine composition for treatment. One of ordinary skill in the art would know how to select a particular viral or cancer antigen for a condition or disease to be prevented or treated. This may include, but is not limited to, any infectious disease or cancer antigen capable of eliciting an immune response, such as a viral envelope glycoprotein or glycoprotein complex, an immunodominant T cell antigen, or a mutated cancer neoantigen. These antigenic sequences, or portions thereof, are derived from a virus such as CMV, EBV, KSHV, other herpesviruses, Zika virus, Lassa virus, HCV, HBV, coronavirus, influenza, or any other virus, bacteria, or other form of an infectious pathogen. or may be based on it.
하기 실시예는 본 발명의 다양한 실시양태를 예시하기 위해 의도된다. 따라서, 논의된 특정 실시양태는 본 발명의 범위에 대한 제한으로서 구성되어서는 안 된다. 본 발명의 범위로부터 벗어나지 않고 다양한 등가물, 변화, 및 변형이 이루어질 수 있다는 것은 관련 기술분야의 통상의 기술자에게 명백할 것이고, 이러한 등가물 실시양태는 본원에 포함되어야 하는 것으로 이해된다. 추가로, 본 개시내용에 인용된 모든 참고문헌은 본원에 완전히 명시된 바와 같이 그 전문이 본원에 참조로서 포함된다.The following examples are intended to illustrate various embodiments of the invention. Accordingly, the specific embodiments discussed should not be construed as limitations on the scope of the invention. It will be apparent to those skilled in the art that various equivalents, changes, and modifications can be made without departing from the scope of the invention, and it is understood that such equivalent embodiments should be embraced herein. Additionally, all references cited in this disclosure are hereby incorporated by reference in their entirety as if fully set forth herein.
실시예Example
실시예 1: 원형 형태의 합성 MVA 단편을 사용하는 sMVA의 재구성Example 1: Reconstitution of sMVA Using Synthetic MVA Fragment in Circular Form
sMVA 플랫폼을 입증하는 초기 시험으로서, 도 2에 예시된 바와 같은 절차를 원형 형태의 3개의 sMVA 단편으로부터의 sMVA의 재구성을 평가하는 데 사용하였다. 3개의 sMVA 단편 (F1 내지 F3)을 알칼리성 용해에 의해41 BAC로서 클로닝된 큰 DNA 단편의 안정한 증식을 허용하는 EPI300 또는 DH10B 이. 콜라이로부터 단리하고, 원형 플라스미드로서 리포펙션에 의해 BHK 세포의 단층 (6-웰 플레이트 포맷)으로 공동-형질감염시켰다 (~1-2 μg/단편) (도 5). 감염 후 4시간 (hpi)에, BHK 세포를 0.1 감염다중도 (MOI)로 헬퍼 FPV로 감염시켜 MVA 전사 및 DNA 복제를 개시하였다. MVA 단편 중 오직 1개 또는 오직 2개의 조합만으로 형질감염된 FPV-감염된 BHK 세포, 3개의 MVA 단편 모두로 형질감염된 모의-감염된 (비감염된) BHK 세포, 및 FPV로 감염된 모의-형질감염된 BHK 세포를 대조군으로서 사용하였다. 형질감염된/감염된 BHK 세포를 적절한 조건 하에 성장시키고 2일마다 도 5에 예시된 바와 같은 절차를 사용하여 보다 큰 조직 배양 포맷으로 ~1:2 내지 1:3 비율로 분산 (계대)시켰다. sMVA의 재구성을 입증하는 바이러스 플라크 형성 및 진행의 징후 및 세포 병변 효과 (CPE)가 형질감염/감염 후 3-6일 (dpt/i)에 3개의 합성 MVA 단편 모두로 형질감염된 FPV-감염된 BHK 세포 단층에서 검출되었다. 3개의 MVA 단편 모두로 형질감염된 FPV-감염된 BHK 세포의 분산 후 7 내지 8 dpt/i에, 유래된 BHK 세포 단층은 90-100% 감염을 나타냈다. 대조적으로, 특징적인 MVA 바이러스 플라크 형성의 징후 또는 CPE는 어떠한 대조군에서도 관측되지 않았다. sMVA를 100% CPE를 갖는 BHK 세포 단층으로부터 종래의 동결/해동 방법에 의해 제조하고, BHK 세포에 대해 적정하고, 낮은 MOI로 BHK 세포 단층을 감염시키는 데 사용하여 16-72 hpi에 MVA 감염 및 확산을 백시니아 바이러스 당단백질 B5R에 대한 면역염색에 의해 평가하였다16,42.As an initial test to validate the sMVA platform, the procedure as illustrated in Figure 2 was used to evaluate the reconstruction of sMVA from three sMVA fragments in a circular form. EPI300 or DH10B EPI300 or DH10B allowing stable propagation of the cloned large DNA fragment as 41 BAC by alkaline lysis of three sMVA fragments (F1 to F3). It was isolated from E. coli and co-transfected (˜1-2 μg/fragment) into monolayers of BHK cells (6-well plate format) by lipofection as a circular plasmid ( FIG. 5 ). At 4 h post infection (hpi), BHK cells were infected with helper FPV at a multiplicity of infection (MOI) of 0.1 to initiate MVA transcription and DNA replication. FPV-infected BHK cells transfected with only one or a combination of only two of the MVA fragments, mock-infected (uninfected) BHK cells transfected with all three MVA fragments, and mock-transfected BHK cells infected with FPV as controls was used as Transfected/infected BHK cells were grown under appropriate conditions and dispersed (passaged) in a ˜1:2 to 1:3 ratio into a larger tissue culture format using the procedure as illustrated in FIG. 5 every 2 days. FPV-infected BHK cells transfected with all three synthetic MVA fragments 3-6 days post-transfection/infection (dpt/i) with signs of viral plaque formation and progression and cytopathic effect (CPE) demonstrating reconstitution of sMVA was detected in the monolayer. At 7-8 dpt/i after dispersal of FPV-infected BHK cells transfected with all three MVA fragments, the derived BHK cell monolayer showed 90-100% infection. In contrast, no characteristic signs of MVA virus plaque formation or CPE were observed in any controls. MVA infection and spread at 16-72 hpi using sMVA prepared by conventional freeze/thaw methods from BHK cell monolayers with 100% CPE, titrated for BHK cells, and used to infect BHK cell monolayers at low MOI. was evaluated by immunostaining for the vaccinia virus glycoprotein B5R 16,42 .
이 분석은 재구성된 sMVA가 특징적인 MVA 바이러스 포커스를 형성하고 BHK 세포 단층에서 확산되는 MVA NIH 클론 1과 비교하여 유사한 능력을 갖는다는 것을 나타냈고 (도 6), 이는 3개의 sMVA 단편으로부터의 sMVA의 형성을 확인한다. 특징적인 바이러스 포커스가 감염 후 1일 (dpi)에 sMVA 및 MVA NIH-감염된 BHK 세포 단층에서 검출되었지만, 2 dpi에는 MVA 바이러스 감염이 sMVA 또는 MVA NIH로 감염된 전체 BHK 세포 단층에서 가시적이었고, 3 dpi에는 sMVA 또는 MVA NIH로 감염된 BHK 세포 단층의 대부분의 세포가 분리되었다. 대조적으로, 특징적인 MVA 바이러스 감염 또는 CPE는 모의-감염된 대조군에서 검출되지 않았다. 다른 연구 그룹은 결정적으로 헬퍼 바이러스로서 사용된 FPV가 BHK 또는 CEF 세포 상 형질감염/감염 인큐베이션으로 도입될 때 유전적 물질을 주지 않거나 또는 MVA 게놈과 재조합한다는 것을 입증하였다43,44.This analysis showed that reconstituted sMVA had a similar ability compared to
재구성된 sMVA의 게놈을 특징규명하기 위해, sMVA-감염된 BHK 세포로부터 제조된 바이러스 DNA를 3개의 합성 MVA 단편 내 상이한 게놈 위치에 특이적인 프라이머를 사용하는 PCR에 의해 평가하였다. 모의-감염된 (비감염된) BHK 세포 뿐만 아니라 NIH MVA 클론 1로 감염된 BHK 세포로부터 제조된 DNA를 대조군으로서 사용하였다. 이 PCR 분석은 재구성된 sMVA의 게놈 DNA 내에서 3개의 sMVA 단편 모두로부터 유래된 DNA의 존재를 밝혀냈다 (도 7). sMVA-감염된 BHK 세포로부터 유래된 모든 PCR 산물은 MVA NIH-감염된 BHK 세포로부터 유래된 것과 비교하여 (분자량 면에서) 유사하였다. 이는 (1) sMVA F1 및 F3 내에 위치한 ITR 서열로부터 유래된 PCR 산물 (도 7A); (2) sMVA F1-유래된 DNA 예컨대 내부 UR의 좌측 단부로의 좌측 ITR의 전이 (도 7B), 및 Del2 삽입 부위 (도 7C)에 상응하는 PCR 산물; (3) sMVA F2-유래된 DNA 예컨대 G1L/I8R 삽입 부위 (IGR69/70)에 상응하는 PCR 산물 (도 7D); 및 sMVA F3-유래된 DNA 예컨대 Del3 삽입 부위 (도 7E), 우측 ITR로의 내부 UR의 우측 단부의 전이 (도 7F)에 상응하는 PCR 산물을 포함하였다. 또한, sMVA F1/F2 또는 sMVA F2/F3 중첩된 상동성 서열 (도 1)에 플랭킹된 결합 부위를 갖는 프라이머를 사용한 PCR 분석은 MVA 및 MVA NIH-감염된 BHK 세포에 대해 유사한 산물 크기를 나타냈고 (도 7G-7H), 이는 3개의 sMVA 단편의 성공적인 재조합 및 sMVA에서의 벡터 서열의 제거를 나타낸다.To characterize the genome of reconstituted sMVA, viral DNA prepared from sMVA-infected BHK cells was evaluated by PCR using primers specific for different genomic locations within three synthetic MVA fragments. DNA prepared from mock-infected (uninfected) BHK cells as well as BHK cells infected with
sMVA-감염된 BHK 세포로부터 유래된 모든 PCR 산물의 생어(Sanger) 시퀀싱 분석은 F1/F2 및 F2/F3의 재조합 부위를 포함하는 MVA 균주 앙투안의 공개된 서열26과 동일한 이들 게놈 위치에서의 서열을 밝혀냈다. 이에 대한 유일한 예외는 오픈 리딩 프레임 (ORF) 021L의 3개의 염기 쌍 하류에서 IGR에 위치한 단일 T에서 A로의 뉴클레오티드 변경을 나타내는 sMVA의 Del2 부위로부터 유래된 PCR 산물이었다26. BLAST 분석은 sMVA DNA 내 이 서열 변경이 어떠한 공개된 MVA 또는 백시니아 바이러스 게놈 서열에도 존재하지 않는다는 것을 나타냈다. 이. 콜라이로부터 정제된 sMVA F1의 생어 서열 분석은 Del2 부위에서의 이 특이적인 뉴클레오티드 변경이 BHK 세포에서의 sMVA 재구성 전에 이미 존재하였다는 것을 나타냈고, 이는 그가 F1의 화학적 합성에서 그의 기원을 갖거나 또는 이. 콜라이에서의 sMVA F1의 클로닝 또는 증식의 결과인 것을 시사한다. sMVA-감염된 BHK 세포로부터 유래된 PCR 산물 (도 7I-7L)의 추가적인 시퀀싱 분석은 sMVA 게놈 서열이 그를 MVA NIH 클론 1의 게놈 서열과 구별하는 내부 UR의 5개의 앙투안 특이적 뉴클레오티드 다형성 모두를 함유한다는 것을 나타냈다.Sanger sequencing analysis of all PCR products derived from sMVA-infected BHK cells revealed sequences at these genomic locations identical to published SEQ ID NOs: 26 of MVA strain Antoine containing recombination sites of F1/F2 and F2/F3. . The only exception to this was a PCR product derived from the Del2 site of sMVA, which exhibits a single T to A nucleotide change located at the
하기 DNA 서열이 DNA 분자의 센스 가닥의 뉴클레오티드 서열 (5'에서 3')로서 제공된다. sMVA 단편 1의 서열 (F1, 60021 bp 길이) (서열식별번호: 11):The following DNA sequence is provided as the nucleotide sequence (5' to 3') of the sense strand of the DNA molecule. Sequence of sMVA fragment 1 (F1, 60021 bp in length) (SEQ ID NO: 11):
sMVA 단편 F1, F2, 및 F3의 서열 중 임의의 것은 하나 이상의 변경 또는 변이를 함유할 수 있다. 예를 들어, sMVA 단편 F1의 서열 (수탁 번호 MW023923 하에 NCBI에 기탁됨, www.ncbi.nlm.nih.gov/nuccore/MW023923.1/)은 오픈 리딩 프레임 021의 비-코딩 결정 영역 하류에서 1개의 뉴클레오티드 변경을 함유한다 (서열식별번호: 12):Any of the sequences of sMVA fragments F1, F2, and F3 may contain one or more alterations or mutations. For example, the sequence of sMVA fragment F1 (deposited to NCBI under accession number MW023923, www.ncbi.nlm.nih.gov/nuccore/MW023923.1/) is 1 downstream of the non-coding decision region of open reading frame 021. contains nucleotide alterations (SEQ ID NO: 12):
sMVA 단편 2의 서열 (F2, 63035 bp 길이) (수탁 번호 MW023924 하에 NCBI에 기탁됨, www.ncbi.nlm.nih.gov/nuccore/MW023924.1/) (서열식별번호: 13):Sequence of sMVA fragment 2 (F2, 63035 bp in length) (deposited at NCBI under accession number MW023924, www.ncbi.nlm.nih.gov/nuccore/MW023924.1/) (SEQ ID NO: 13):
sMVA 단편 3의 서열 (F3, 62068 bp 길이) (서열식별번호: 14):Sequence of sMVA fragment 3 (F3, 62068 bp in length) (SEQ ID NO: 14):
대안적으로, sMVA F3의 서열은 ITR 서열의 단부에 가까운 88 bp에서의 비-코딩 결정 영역에서 1개의 뉴클레오티드 변경을 함유할 수 있다 (수탁 번호 MW030459 하에 NCBI에 기탁됨, www.ncbi.nlm.nih.gov/nuccore/MW030459.1/) (서열식별번호: 15):Alternatively, the sequence of sMVA F3 may contain one nucleotide alteration in the non-coding determining region at 88 bp proximal to the end of the ITR sequence (deposited to NCBI under accession number MW030459, www.ncbi.nlm. nih.gov/nuccore/MW030459.1/) (SEQ ID NO: 15):
또한 완전한 백시니아 바이러스 게놈을 재구성하기 위한 합성 백시니아 바이러스 (sVAC) 단편의 예가 개시된다. sVAC 단편 1의 예시 서열 (F1, 66679 bp 길이) (서열식별번호: 16):Also disclosed are examples of synthetic vaccinia virus (sVAC) fragments for reconstructing the complete vaccinia virus genome. Exemplary sequence of sVAC fragment 1 (F1, 66679 bp in length) (SEQ ID NO: 16):
sVAC 단편 2의 예 (F2, 66679 bp 길이) (서열식별번호: 17):Example of sVAC fragment 2 (F2, 66679 bp long) (SEQ ID NO: 17):
sVAC 단편 3의 예시 서열 (F3, 66679 bp 길이) (서열식별번호: 18):Exemplary sequence of sVAC fragment 3 (F3, 66679 bp in length) (SEQ ID NO: 18):
sMVA 재구성 후 박테리아 벡터 서열의 제거를 평가하기 위해, BHK 세포에서의 sMVA의 일련의 바이러스 계대 시 sMVA-감염된 BHK 세포의 DNA를 박테리아 벡터의 sopA 및 cat 클로람페니콜 내성 유전자에 특이적인 프라이머를 사용하는 PCR에 의해 평가하였다. 이 PCR 분석은 비록 sMVA의 2회의 추가적인 바이러스 계대 후에는 sMVA DNA에서 검출가능하지 않았지만, 잔류 벡터 서열이 7 또는 8 dpt/i에 sMVA DNA에서 검출될 수 있다는 것을 나타냈다. 이들 결과는 종합하면 원형 플라스미드 분자로서 3개의 합성 MVA 단편의 FPV-감염된 BHK 세포로의 공동-형질감염이 MVA 균주 앙투안의 공개된 게놈 서열26과 유사한 서열 조성을 갖는 것으로 보이는 전장, 벡터-무함유 게놈을 갖는 sMVA의 형성을 일으킨다는 증거를 제공한다.To evaluate the removal of bacterial vector sequences after sMVA reconstitution, DNA from sMVA-infected BHK cells during serial viral passage of sMVA in BHK cells was subjected to PCR using primers specific for the sopA and cat chloramphenicol resistance genes of the bacterial vector. evaluated by This PCR analysis indicated that residual vector sequences could be detected in sMVA DNA at 7 or 8 dpt/i, although after two additional viral passages of sMVA were not detectable in sMVA DNA. Taken together, these results show that co-transfection of three synthetic MVA fragments as circular plasmid molecules into FPV-infected BHK cells appears to have a sequence composition similar to that of the published genome SEQ ID NO: 26 of MVA strain Antoine, a full-length, vector-free genome. provides evidence that it causes the formation of sMVA with
실시예 2: 단일 이종성 유전자 서열을 발현하는 재조합 sMVA의 생성Example 2: Generation of recombinant sMVA expressing a single heterologous gene sequence
rsMVA를 생성하기 위한 3개의 sMVA 단편의 사용을 평가하기 위해, 3개의 단편을 앙 파상 돌연변이유발39,40에 의해 큰 BAC-클로닝된 DNA 분자를 조작하는 데 사용되는 GS1783 이. 콜라이 세포40로 전달하였다. 이 매우 효율적인 방법은 어떠한 박테리아 마커 서열도 남기지 않는 레드 재조합에 기반한 2-단계 돌연변이유발 절차에 의해 BAC 클로닝된 DNA 분자로의 점 돌연변이 또는 큰 또는 작은 서열 삽입 또는 결실의 도입을 허용한다39,40. 이종성 유전자 서열을 발현하는 rsMVA를 생성하기 위한 sMVA 플랫폼의 초기 시험으로서, 단일 형광 마커를 발현하는 rsMVA의 생성을 평가하였다. MVABAC-TK로의 항원 서열의 삽입에 대해 이전에 기재된 바와 같이18,24, 앙 파상 돌연변이유발을 상류 mH5 프로모터 및 하류 TTTTTAT 백시니아 바이러스 전사 종결 신호와 함께 적색 형광 단백질 (RFP) 마커로 구성된 발현 카세트를 sMVA 단편 F2 내 IGR69/70 (또한 G1L/I8R로 공지됨) 삽입 부위로 삽입하는 데 사용하여 F2-RFP를 생성하였다 (도 3). 조작된 sMVA 단편의 서열 온전성을 유전자 삽입 부위의 제한 단편 길이 다형성 (RFLP) 분석 뿐만 아니라 PCR 및 생어 시퀀싱 분석에 의해 결정하였다. 삽입된 RFP 마커를 갖는 변형된 sMVA 단편 F2 뿐만 아니라 비변형된 sMVA 단편 F1 및 F3을 이. 콜라이로부터 단리하고 BHK 세포로 공동-형질감염시켜 도 5에 예시된 바와 같은 절차를 사용하여 헬퍼 바이러스로서의 FPV의 존재 하에 rsMVA의 재구성을 평가하였다. 도 8에 제시된 바와 같이, 면역형광 이미징은 3-6 dpt/i에서의 F1/F2-RFP/F3 플라스미드 조합으로 형질감염된 BHK 세포 단층의 적색 형광 바이러스 플라크의 형성 및 진행을 밝혀냈지만, 7 dpt/i에는 RFP 발현이 전체 BHK 세포 단층에서 가시적이었다. 대조적으로, RFP 발현은 모의-형질감염된/감염된 BHK 세포 단층에서 가시적이지 않았다. 이들 결과는 종합하면 sMVA 플랫폼이 단일 이종성 유전자 서열을 발현하는 rsMVA를 신속하게 생성하는 데 사용될 수 있다는 것을 입증한다.To evaluate the use of three sMVA fragments to generate rsMVA , the three fragments were transformed into GS1783 e. transferred to E. coli cells 40 . This highly efficient method allows the introduction of point mutations or large or small sequence insertions or deletions into BAC cloned DNA molecules by a two-step mutagenesis procedure based on red recombination that leaves no bacterial marker sequences 39,40 . As an initial test of the sMVA platform to generate rsMVA expressing heterologous gene sequences, the generation of rsMVA expressing a single fluorescent marker was evaluated. 18,24 As previously described for insertion of the antigenic sequence into MVABAC -TK, umbilical mutagenesis was performed using an expression cassette consisting of a red fluorescent protein (RFP) marker with an upstream mH5 promoter and a downstream TTTTTAT vaccinia virus transcription termination signal. F2-RFP was generated using insertion into the IGR69/70 (also known as G1L/I8R) insertion site in sMVA fragment F2 ( FIG. 3 ). The sequence integrity of the engineered sMVA fragment was determined by restriction fragment length polymorphism (RFLP) analysis of the gene insertion site as well as PCR and Sanger sequencing analysis. The modified sMVA fragment F2 with the inserted RFP marker as well as the unmodified sMVA fragments F1 and F3 were transferred to E. Reconstitution of rsMVA in the presence of FPV as a helper virus was evaluated using a procedure as illustrated in FIG. 5 by isolation from E. coli and co-transfection into BHK cells. As shown in Figure 8, immunofluorescence imaging revealed the formation and progression of red fluorescent viral plaques in BHK cell monolayers transfected with the F1/F2-RFP/F3 plasmid combination at 3-6 dpt/i, but at 7 dpt/i. In i, RFP expression was visible in the whole BHK cell monolayer. In contrast, RFP expression was not visible in mock-transfected/infected BHK cell monolayers. Taken together, these results demonstrate that the sMVA platform can be used to rapidly generate rsMVA expressing a single heterologous gene sequence.
실시예 3: 2종의 이종성 유전자 서열을 발현하는 재조합 sMVA의 생성Example 3: Generation of recombinant sMVA expressing two heterologous gene sequences
상이한 게놈 위치로 삽입된 다수의 이종성 유전자 서열을 갖는 rsMVA의 생성을 위한 sMVA 플랫폼을 평가하기 위해, 2종의 형광 마커를 발현하는 rsMVA의 구축을 평가하였다. GS1783 세포의 앙 파상 돌연변이유발을 사용하여, P11 프로모터, RFP 마커 또는 청색 형광 단백질 (BFP) 마커, 및 TTTTTAT 전사 종결 신호로 구성된 유전자 발현 카세트를 개별적으로 sMVA F2의 IGR69/70 및 sMVA F3의 Del3 부위로 삽입하였다. 삽입된 RFP 마커를 갖는 변형된 sMVA F2 (F2-RFP) 및 삽입된 BFP 마커를 갖는 변형된 sMVA F3 (F3-BFP)을 GS1783 이. 콜라이 세포로부터 단리하고 비변형된 sMVA F1과 함께 BHK 세포로 공동-형질감염시켜 도 5에 제시된 절차를 사용하여 헬퍼 바이러스의 존재 하에 RFP 및 BFP 마커를 갖는 rsMVA의 재구성을 평가하였다. 도 9에 제시된 바와 같이, 면역형광 이미징은 3-6 dpt/i에서의 F1/F2-RFP/F3-BFP 플라스미드 조합으로 공동-형질감염된 BHK 세포 단층의 이중 형광 (적색 및 청색) 바이러스 플라크의 형성을 입증하였고, 7 dpt/i에 대부분의 또는 모든 BHK 세포가 RFP 및 BFP 이중 형광 단백질 발현을 나타내는 것으로 보였다. 이들 결과는 sMVA 플랫폼이 상이한 삽입 부위로 삽입된 2종의 이종성 유전자 서열을 발현하는 rsMVA를 신속하게 생성하는 데 사용될 수 있다는 증거를 제공한다.To evaluate the sMVA platform for the generation of rsMVA with multiple heterologous gene sequences inserted into different genomic locations, the construction of rsMVA expressing two fluorescent markers was evaluated. Using umbilical mutagenesis of GS1783 cells, gene expression cassettes consisting of the P11 promoter, RFP marker or blue fluorescent protein (BFP) marker, and TTTTTAT transcription termination signal were individually transfected into the IGR69/70 of sMVA F2 and the Del3 sites of sMVA F3. inserted into The modified sMVA F2 (F2-RFP) with the inserted RFP marker and the modified sMVA F3 (F3-BFP) with the inserted BFP marker were combined with GS1783 E. Reconstitution of rsMVA with RFP and BFP markers in the presence of helper virus was assessed using the procedure presented in FIG. 5 by isolation from E. coli cells and co-transfection into BHK cells with unmodified sMVA F1. As shown in Figure 9, immunofluorescence imaging revealed the formation of double fluorescent (red and blue) viral plaques of BHK cell monolayers co-transfected with the F1/F2-RFP/F3-BFP plasmid combination at 3-6 dpt/i. , and at 7 dpt/i most or all of the BHK cells appeared to express RFP and BFP dual fluorescent protein expression. These results provide evidence that the sMVA platform can be used to rapidly generate rsMVA expressing two heterologous gene sequences inserted into different insertion sites.
실시예 4: 3종의 이종성 유전자 서열을 발현하는 재조합 sMVA의 생성Example 4: Generation of recombinant sMVA expressing three heterologous gene sequences
다수의 삽입된 이종성 유전자 서열을 갖는 rsMVA의 생성을 위한 sMVA 플랫폼을 추가로 평가하기 위해, 3종의 형광 마커를 발현하는 rsMVA의 생성을 조사하였다. 이. 콜라이에서 앙 파상 돌연변이유발을 사용하여, 상류 P11 프로모터 및 하류 전사 종결 신호와 함께 녹색 형광 단백질 (GFP) 마커를 MVA F1의 IGR44/45로 삽입하였다. 이어서, 삽입된 GFP 마커를 갖는 생성된 변형된 sMVA 단편 F1 (F1-GFP)을 형광 태그부착된 형태의 F2 및 F3 (F2-RFP 및 F3-BFP) 뿐만 아니라 F1, F2, 및 F3의 비변형된 sMVA 단편과 상이한 조합으로 시험하여 도 5에 제시된 절차를 사용하여 단일, 이중, 또는 삼중 형광 sMVA 발현 벡터를 평가하였다. 공동-형질감염에 사용된 단편 조합은 F1-GFP/F2-RFP/F3-BFP, F1-GFP/F2-RFP/F3, F1-GFP/F2/F3-BFP, F1/F2-RFP/F3-BFP, F1-GFP/F2/F3, F1/F2-RFP/F3, 및 F1/F2/F3-BFP를 포함하였다. FPV-감염된 BHK 세포로의 3개의 비-변형된 sMVA 단편 (F1/F2/F3)의 공동-형질감염을 음성 대조군으로서 평가하였다. 음성 대조군을 제외하고, 형광 유전자 발현이 면역형광 이미징에 의해 3-6 dpt/i에 상이한 단편 조합 중 임의의 것으로 형질감염된 BHK 세포 단층에서 관측되었다. 7 내지 8 dpt/i에, 형광 마커 발현이 BHK 단층의 대부분의 세포에서 관측되었고, 이는 형광 재조합 sMVA 발현 벡터의 재구성을 나타낸다. 재조합 sMVA 발현 벡터를 동결/해동 기술에 의해 제조하고, BHK 세포에 대해 적정하고, 낮은 MOI로 BHK 세포 단층을 감염시키는 데 사용하였다. 16-24 hpi에, 감염된 BHK 세포 단층을 IF 이미징에 의해 평가하여 상이한 형광 마커 서열을 발현하는 sMVA의 형성 및 재구성을 확인하였다. 이 분석은 F1-GFP/F2-RFP/F3-BFP-유래된 sMVA로 감염된 BHK 세포 단층에서의 삼중 형광 발현; F1-GFP/F2-RFP/F3, F1-GFP/F2/F3-BFP, 또는 F1/F2-RFP/F3-BFP-유래된 sMVA로 감염된 BHK 세포 단층에서의 이중 형광 발현; 및 F1-GFP/F2/F3, F1/F2-RFP/F3, 또는 F1/F2/F3-BFP-유래된 sMVA로 감염된 BHK 세포 단층에서의 단일 형광 발현을 나타낸 바이러스 포커스의 형성을 밝혀냈다. 이들 결과는 종합하면 3개의 sMVA 단편이 이. 콜라이에서 조작되고 단일, 이중, 또는 삼중 재조합 sMVA 발현 벡터를 재구성하는 데 원형 DNA 분자로서 사용될 수 있다는 것을 나타내고, 이는 재조합 백신 벡터를 생성하기 위한 3개의 sMVA 단편의 가능성을 강조한다.To further evaluate the sMVA platform for the generation of rsMVA with multiple inserted heterologous gene sequences, the generation of rsMVA expressing three fluorescent markers was investigated. this. Green fluorescent protein (GFP) markers were inserted into the IGR44/45 of MVA F1, along with the upstream P11 promoter and downstream transcription termination signal, using en wave mutagenesis in E. coli. The resulting modified sMVA fragment F1 (F1-GFP) with the GFP marker inserted was then transfected with fluorescently tagged forms of F2 and F3 (F2-RFP and F3-BFP) as well as unmodified F1, F2, and F3. Single, double, or triple fluorescent sMVA expression vectors were evaluated using the procedure shown in FIG. 5 by testing different combinations of sMVA fragments. The fragment combinations used for co-transfection were F1-GFP/F2-RFP/F3-BFP, F1-GFP/F2-RFP/F3, F1-GFP/F2/F3-BFP, F1/F2-RFP/F3- BFP, F1-GFP/F2/F3, F1/F2-RFP/F3, and F1/F2/F3-BFP. Co-transfection of three non-modified sMVA fragments (F1/F2/F3) into FPV-infected BHK cells was evaluated as a negative control. Except for the negative control, fluorescent gene expression was observed in BHK cell monolayers transfected with any of the different fragment combinations at 3-6 dpt/i by immunofluorescence imaging. At 7-8 dpt/i, fluorescent marker expression was observed in most cells of the BHK monolayer, indicating reconstitution of the fluorescent recombinant sMVA expression vector. Recombinant sMVA expression vectors were prepared by freeze/thaw technique, titrated to BHK cells, and used to infect BHK cell monolayers at low MOIs. At 16-24 hpi, infected BHK cell monolayers were evaluated by IF imaging to confirm the formation and reconstitution of sMVA expressing different fluorescent marker sequences. This assay analyzed triple fluorescence expression in BHK cell monolayers infected with F1-GFP/F2-RFP/F3-BFP-derived sMVA; double fluorescence expression in BHK cell monolayers infected with F1-GFP/F2-RFP/F3, F1-GFP/F2/F3-BFP, or F1/F2-RFP/F3-BFP-derived sMVA; and formation of viral foci that exhibited single fluorescence expression in BHK cell monolayers infected with F1-GFP/F2/F3, F1/F2-RFP/F3, or F1/F2/F3-BFP-derived sMVA. Taken together, these results show that the three sMVA fragments are E. It shows that it can be used as a circular DNA molecule to reconstruct single, double, or triple recombinant sMVA expression vectors engineered in E. coli, highlighting the potential of three sMVA fragments to generate recombinant vaccine vectors.
실시예 5: 감염성 질환 항원 변형된 MVA의 실시예의 구축 및 평가Example 5: Construction and evaluation of examples of infectious disease antigen-modified MVA
감염성 질환에 대한 다중-항원 백신 벡터를 생성하기 위한 sMVA 플랫폼의 유용성을 입증하기 위해, gH, gL, UL128, UL130, 및 UL131A로 구성된 HCMV 외피 오량체 복합체 (PC)의 5개의 구성원을 발현하는 rsMVA의 구축을 평가한다. 2A-연결된 gH/gL 및 UL128/UL130/UL131A 서브유닛으로 구성된 항원 발현 카세트를 개별적으로 이. 콜라이에서 앙 파상 돌연변이유발을 사용하여 sMVA F2에 위치한 IGR69/70 및 sMVA F3에 위치한 Del3 부위로 삽입한다. F2 및 F3의 변형된 sMVA 단편을 F1의 비변형된 sMVA 단편과 함께 FPV-감염된 BHK 세포로 형질감염시켜 5개의 PC 서브유닛 모두를 발현하는 sMVA (rsMVA-PC)를 재구성한다. 대조군으로서, 단지 gH/gL 또는 UL128/130/131A 서브유닛만을 발현하는 rsMVA 뿐만 아니라 어떠한 삽입된 항원 서열도 없는 sMVA를 생성한다. 항원 서열의 발현을 웨스턴 블롯에 의해 확인하고, rsMVA-PC로부터 발현되는 PC 서브유닛에 의한 다중-단백질 복합체의 형성을 PC의 2개 이상의 서브유닛에 의해 형성된 구조적 에피토프를 표적하는 중화 항체 (NAb)를 사용하는 유세포 분석 (FC)에 의해 확인한다. NAb를 자극하는 rsMVA-PC 벡터의 면역원성을 조사하기 위해, Balb/c 마우스를 복강내 경로에 의해 4주 간격으로 rsMVA-PC 또는 대조군 벡터로 3회 면역화시킨다. 면역화 후 다양한 시점에서, HCMV-특이적 NAb 반응을 MRC-5 섬유모세포 (FB) 및 ARPE-19 상피 세포 (EC)에 대해 측정한다. 이 분석은 rsMVA-PC로 면역화된 마우스에서 FB 및 EC-특이적 NAb 반응의 강력한 자극을 밝혀낼 수 있는 반면에, 대조군 벡터로 면역화된 마우스에서는 반응이 측정되지 않거나 또는 단지 최소한의 반응만 측정된다. 이들 결과는 sMVA 백신 플랫폼이 서로 조립되어 NAb 에피토프를 형성하고 마우스에서 강력한 NAb 반응을 자극하는 5개의 PC 서브유닛 모두를 발현하는 다중-항원 MVA 백신 벡터를 생성하는 데 사용될 수 있다는 것을 입증할 수 있다.To demonstrate the utility of the sMVA platform for generating multi-antigen vaccine vectors against infectious diseases, rsMVA expressing five members of the HCMV envelope pentamer complex (PC) consisting of gH, gL, UL128, UL130, and UL131A evaluate the construction of Antigen expression cassettes composed of 2A-linked gH/gL and UL128/UL130/UL131A subunits were individually isolated from E. In E. coli, hem-wave mutagenesis was used to insert into the IGR69/70 located in sMVA F2 and the Del3 site located in sMVA F3. The modified sMVA fragments of F2 and F3 together with the unmodified sMVA fragments of F1 were transfected into FPV-infected BHK cells to reconstruct sMVA expressing all five PC subunits (rsMVA-PC). As a control, rsMVA expressing only gH/gL or UL128/130/131A subunits as well as sMVA without any inserted antigen sequence are generated. The expression of the antigen sequence was confirmed by Western blot, and the formation of a multi-protein complex by the PC subunit expressed from rsMVA-PC was a neutralizing antibody (NAb) targeting a structural epitope formed by two or more subunits of PC. Confirm by flow cytometry (FC) using To investigate the immunogenicity of rsMVA-PC vectors stimulating NAb, Balb/c mice are immunized three times with rsMVA-PC or control vectors at 4-week intervals by the intraperitoneal route. At various time points after immunization, HCMV-specific NAb responses are measured for MRC-5 fibroblasts (FB) and ARPE-19 epithelial cells (EC). This assay can reveal potent stimulation of FB and EC-specific NAb responses in mice immunized with rsMVA-PC, whereas no or only minimal responses are measured in mice immunized with control vectors. . These results can demonstrate that the sMVA vaccine platform can be used to generate multi-antigen MVA vaccine vectors that assemble together to form NAb epitopes and express all five PC subunits that stimulate robust NAb responses in mice. .
실시예 6: sMVA로부터 발현되는 2019-nCoV의 구축 및 평가Example 6: Construction and evaluation of 2019-nCoV expressed from sMVA
새롭고, 매우 전염성 및 병원성의 코로나바이러스로서 최근에 발생된 코로나바이러스 균주 2019-nCoV (우한(Wuhan))에 대한 백신을 생성하기 위한 sMVA 플랫폼의 유용성에 대한 실시예가 예시된다. 코로나바이러스의 S (스파이크) 단백질이 수용체 인식, 뿐만 아니라 바이러스 부착 및 진입에 관여하고, 체액성 및 세포성 면역을 보호하는 우세한 표적이기 때문에, 이는 코로나바이러스 (CoV) 백신 및 치료제의 개발에 대한 잠재적인 표적을 나타낸다. 2019-nCoV 균주의 전장 S 단백질 (~1273개의 아미노산), S 단백질의 면역원성 S1 도메인, 또는 S1 도메인의 수용체 결합 도메인 (RBD)을 코딩하는 cDNA를 개별적으로 sMVA 단편 F3의 MVA Del3 부위로 삽입한다. 이어서, sMVA F3의 생성된 변형된 단편을 비변형된 버전의 sMVA 단편 F1 및 F2와 함께 BHK 세포로 공동-형질감염시켜 도 5에 예시된 바와 같은 절차를 사용하여 새로운 코로나바이러스 S 단백질 (sMVA-2019-nCoV-S), S1 도메인 (sMVA-2019-nCoV-S1), 또는 RBD 도메인 (sMVA-2019-nCoV-RBD)을 발현하는 sMVA의 재구성을 개시한다. sMVA 재조합체로부터의 S 단백질, S1 도메인, 또는 RBD 도메인의 발현을 면역블롯 및 유세포 분석 분석에 의해 확인한다. 감염된 인간, 마우스 또는 토끼로부터의 회복기 혈청을 면역블롯에 대한 검출 시약으로서 사용한다. 일부 경우에, 태그 예컨대 HA를 카르복실 말단에 공유 부착하고, 이들에 대한 항체를 면역블롯 또는 유세포 분석에 대한 검출 시약으로서 사용한다. 유사하게, 추가적인 면역원성 단백질, 예를 들어 2019-nCoV로부터의 N 또는 M 항원을 sMVA의 고유 유전자 삽입 영역으로 삽입하여 다중-항원 백신을 개발한다. 예를 들어, 이들 2019-nCoV 항원 중 하나 이상을 하나 이상의 삽입 부위 예컨대 sMVA 단편 F3의 Del3 부위 및 sMVA 단편 F2의 IGR69/70에 삽입한다.Examples of the utility of the sMVA platform for generating vaccines against the recently emerged coronavirus strain 2019-nCoV (Wuhan) as a novel, highly contagious and pathogenic coronavirus are illustrated. As the S (spike) protein of coronavirus is involved in receptor recognition, as well as virus attachment and entry, and is the predominant target for protecting humoral and cellular immunity, it has potential for the development of coronavirus (CoV) vaccines and therapeutics. indicates a target. cDNAs encoding the full-length S protein (~1273 amino acids), the immunogenic S1 domain of the S protein, or the receptor binding domain (RBD) of the S1 domain of the 2019-nCoV strain are individually inserted into the MVA Del3 site of the sMVA fragment F3 . The resulting modified fragment of sMVA F3 was then co-transfected with unmodified versions of sMVA fragments F1 and F2 into BHK cells using the procedure as exemplified in FIG. 5 for novel coronavirus S protein (sMVA- Reconstitution of sMVA expressing 2019-nCoV-S), S1 domain (sMVA-2019-nCoV-S1), or RBD domain (sMVA-2019-nCoV-RBD) is disclosed. Expression of the S protein, S1 domain, or RBD domain from the sMVA recombinant is confirmed by immunoblot and flow cytometry analysis. Convalescent sera from infected humans, mice or rabbits are used as detection reagents for immunoblots. In some cases, tags such as HA are covalently attached to the carboxyl terminus, and antibodies to them are used as detection reagents for immunoblot or flow cytometry. Similarly, multi-antigen vaccines are developed by inserting additional immunogenic proteins, such as N or M antigens from 2019-nCoV, into the native gene insertion region of sMVA. For example, one or more of these 2019-nCoV antigens are inserted into one or more insertion sites such as the Del3 site of sMVA fragment F3 and IGR69/70 of sMVA fragment F2.
sMVA 구축물의 면역원성 및 보호 효능을 시험하기 위해, 2종의 동물 모델을 사용할 수 있다: (1) 노령 개체에서 관측되는 보다 심각한 증상을 고려하여, 12개월령 Balb/c 마우스를 피하 및 근육내 경로에 의해 4주 간격으로 1x107-1x108의 sMVA 플라크 형성 단위 (Pfu)로 2회 면역화시키고; (2) 폐 세포로의 nCoV 진입에서 인간 안지오텐신-전환 효소-2 (hACE-2)의 잠재적인 관여를 고려하여, 인간 hACE2 수용체를 발현하는 트랜스제닉 마우스를 백신 효능을 시험하는 데 사용한다.To test the immunogenicity and protective efficacy of sMVA constructs, two animal models can be used: (1) given the more severe symptoms observed in elderly individuals, 12-month-old Balb/c mice were treated by subcutaneous and intramuscular routes. immunized twice with 1x10 7 -1x10 8 sMVA plaque forming units (Pfu) at 4 week intervals by (2) Considering the potential involvement of human angiotensin-converting enzyme-2 (hACE-2) in nCoV entry into lung cells, transgenic mice expressing the human hACE2 receptor are used to test vaccine efficacy.
sMVA 구축물의 면역원성 및 보호 효능을 시험하기 위해, 안지오텐신 전환 효소 2 (ACE2)에 대한 트랜스제닉 Balb/c 마우스를 피하 및 근육내 경로에 의해 4주 간격으로 1x107-1x108의 sMVA 플라크 형성 단위 (Pfu)로 2회 면역화시킨다. 2019-nCoV-S 단백질 및 유도체에 특이적인 중화 항체 반응 및 T 세포 반응을 각각의 면역화 후 1주에 이전에 기재된 바와 같이 측정한다. 부스터 면역화 후 45일에, 마우스를 7 x 104 50% 조직 배양 감염 용량 (TICD50)의, 백신 항원과 상동성인 2019-nCoV, 및 이종성 균주 (SARS-CoV 및 MERS-CoV)로 감염시키고 챌린지 후 4일에, 동물을 희생시키고, 이들의 폐를 바이러스 로드의 측정 및 병리조직학적 분석을 위해 수거한다. 평균적으로, 총 RNA의 >11,000 내지 >20,000개의 2019-nCoV 게놈 등가물/ng인 큰 바이러스 로드가 모의-면역화된 및 비재조합 MVA-면역화된 대조군 그룹 둘 다 및 이종성 CoV 균주로 챌린지된 동물에서 발견된다. 뚜렷하게 대조적으로, 단백질 (sMVA-nCoV-S) 또는 S1 도메인 (sMVA-nCoV-S1) 대상체의 폐 조직은 유의하게 보다 낮은 수준의 2019-nCoV RNA (바이러스 로드)를 함유하고, 이는 백신-유도된 면역 반응에 의한 2019-nCoV 복제의 효율적인 억제를 나타낸다. 모든 위약 대조군 동물 (MVA-GFP)은 감염 후 4 내지 8일에 굴복하였지만, MVA-S, MVA-N 및 MVA-N/S는 최소한의 체중 감소를 포함하는 질환의 최소한의 징후를 나타내거나 또는 이를 나타내지 않는다. MVA-N/S 면역화된 마우스는 완전히 보호된다.To test the immunogenicity and protective efficacy of sMVA constructs, Balb/c mice transgenic for angiotensin converting enzyme 2 (ACE2) were treated with 1x10 7 -1x10 8 sMVA plaque forming units at 4-week intervals by subcutaneous and intramuscular routes. (Pfu) for two immunizations. Neutralizing antibody responses and T cell responses specific for 2019-nCoV-S proteins and derivatives are measured as previously described one week after each immunization. At 45 days post booster immunization, mice were infected with 7 x 10 4 50% tissue culture infectious dose (TICD50) of 2019-nCoV homologous to the vaccine antigen, and heterologous strains (SARS-CoV and MERS-CoV) and post-challenge. On day 4, animals are sacrificed and their lungs are harvested for measurement of viral load and histopathological analysis. On average, large viral loads of >11,000 to >20,000 2019-nCoV genome equivalents/ng of total RNA are found in both mock-immunized and non-recombinant MVA-immunized control groups and animals challenged with the heterologous CoV strain . In sharp contrast, the lung tissue of the protein (sMVA-nCoV-S) or S1 domain (sMVA-nCoV-S1) subjects contained significantly lower levels of 2019-nCoV RNA (viral load), which was vaccine-derived. Shows efficient inhibition of 2019-nCoV replication by immune response. All placebo control animals (MVA-GFP) succumbed 4-8 days post infection, but MVA-S, MVA-N and MVA-N/S showed minimal signs of disease, including minimal weight loss, or does not indicate this MVA-N/S immunized mice are fully protected.
병리조직학은 2019-nCoV 서브유닛 항원 면역화된 동물에서 실질적으로 감소된 폐 손상에 초점을 맞추고 있다. 질환의 항체-증강에 대한 가능성이 또한 평가되고 이들 서브유닛 백신 모델에서 부재하는 것으로 발견된다. S 단백질 항원 및 그의 S1 및 RBD 유도체에 대한 NAb 반응을 항원-특이적 NAb에 의한 인식에 강력한 nCoV에 대한 위형화 전략을 사용하여 평가하지만, CoV의 병원성 균주의 사용은 회피된다. S 단백질 및 유도체로 면역화된 동물로부터의 혈청은 상동성 2019-nCoV 균주에 대해 높은 역가 및 중화 항체를 발생시키지만 이종성 CoV 균주 예컨대 MERS 및 SARS에 대한 병인체에 대해서는 아니다. IC90 중화 역가를 각각의 마우스 혈청 샘플에 대해 계산한다. 트랜스제닉 ACE2 Balb/c 마우스 균주에서의 백신 연구의 성공에 기반하여, 계속해서 보다 큰 동물 종, 즉 2019-nCoV 챌린지에 대해 감수성을 갖고 MVA-기반 백신에 반응하는 것으로 공지된 토끼, 페럿, 및 레서스 마카크를 조사한다.Histopathology focuses on substantially reduced lung injury in 2019-nCoV subunit antigen immunized animals. The potential for antibody-enhancing the disease is also assessed and found absent in these subunit vaccine models. NAb responses to S protein antigens and their S1 and RBD derivatives are evaluated using a pseudotyping strategy for nCoV that is robust for recognition by antigen-specific NAbs, but the use of pathogenic strains of CoV is avoided. Sera from animals immunized with the S protein and derivatives elicit high titers and neutralizing antibodies against the homologous 2019-nCoV strain, but not the pathogens against heterologous CoV strains such as MERS and SARS. IC90 neutralizing titers are calculated for each mouse serum sample. Building on the success of vaccine studies in the transgenic ACE2 Balb/c mouse strain, continue to larger animal species, namely rabbits, ferrets, and rabbits, ferrets, and known to respond to MVA-based vaccines with sensitivity to the 2019-nCoV challenge. Examine the rhesus macaque.
실시예 7: 암 항원 변형된 sMVA의 실시예의 구축 및 평가Example 7: Construction and evaluation of examples of cancer antigen-modified sMVA
본 실시예는 ATCC 또는 NIAID로부터 수득된 MVA 백본으로의 이전에 연구에 사용되었던 마우스 p53 유전자의 삽입을 입증한다46. 마우스 p53 cDNA를 추가적인 뉴클레오티드 부가 또는 제거가 로커스의 정확한 삽입 부위에서 이루어지지 않도록 앙 파상을 사용하여 결실 (DEL3) 로커스로 삽입한다. 삽입은 정확하게 이루어지도록 서열 분석에 의해 확인되고 모든 관련된 영역은 무손상이고 100% 서열 확인가능하다. 플라스미드 F3의 변형에 후속하여, 모든 3개의 플라스미드를 단일 분취량으로 실시예 2에 기재된 바와 동일한 방법을 사용하여 조합하고, 변형된 버전의 sMVA를 생성하고, 생 바이러스를 FPV로의 형질감염/감염 2일 후에 수득한다. 생 바이러스를 농축시키고 BHK 세포 상에서 확장하고 스톡을 제조하고, 생어 방법을 사용하여 서열 확인하여 바이러스가 DEL3 로커스에서 p53 유전자 삽입의 정확한 서열을 갖는 것을 확립한다. 더욱이, 바이러스 스톡을 제조하고 동결시키고 장기간 저장하는 동시에, 작동 스톡을 변형된 sMVA 스톡을 ≥1x109 pfu/mL의 역가로 확장하기 위해 공개된 방법을 사용하여 제조한다. 확장된 스톡의 확인을 qPCR, 생어 시퀀싱, 감염성 역가, 및 웨스턴 블롯 분석의 조합을 사용하여 수행한다. 4종의 이들 절차 모두를 수행하고 적절한 결과를 획득하여 뉴클레오티드 서열이 적절한 크기를 갖고, 감염성 역가가 ≥1x109 pfu/mL의 범위 내인 것을 확인하고, 웨스턴 블롯 분석은 대략 53 Kd에서 단백질 밴드를 확인한다. 관련 기술분야의 통상의 기술자는 인간 버전의 p53 유전자를 사용하여 암 진행으로부터 인간을 보호하기 위한 백신으로서 이 접근법을 적용할 수 있다.This example demonstrates the insertion of the mouse p53 gene, previously used in studies, into the MVA backbone obtained from ATCC or NIAID 46 . Mouse p53 cDNA is inserted into the deletion (DEL3) locus using an umbilical cord so that no additional nucleotide additions or removals are made at the correct insertion site of the locus. Insertion is confirmed by sequencing to ensure that the insertion is correct and all relevant regions are intact and 100% sequence identifiable. Following modification of plasmid F3, all three plasmids were combined in a single aliquot using the same method as described in Example 2, to generate a modified version of sMVA, and transfection/infection of live virus with
뮤린 (mu) p53-sMVAMurine (mu) p53-sMVA
암컷 6-8-주령 BALB/C 마우스를 잭슨 래보래토리(Jackson Laboratory) (메인주 바 하버)로부터 획득하고 특이적 병원체-무함유 환경에서 유지한다. 모든 연구는 시티 오브 호프 내셔널 메디컬 센터(City of Hope National Medical Center)의 연구 동물 관리 위원회에 의해 승인되고 미국 실험 동물 관리 인증 협회(American Association for the Accreditation of Laboratory Animal Care) 지침 하에 수행된다. Meth A 육종 세포 (Meth A)는 메모리얼 슬론-케터링 캔서 센터(Memorial Sloan-Kettering Cancer Center) (뉴욕주 뉴욕) 엘제이 올드(LJ Old) 박사의 기증이다. Meth A는 복수 종양으로서 계대된다. 항-CTLA-4 (9H10)는 엠디 앤더슨 캔서 센터(MD Anderson Cancer Center) (텍사스주 휴스턴) 제임슨 앨리슨(James Allison) 박사의 기증이다. 항체를 셀라인(CELLine) 장치 (비디 바이오사이언시스(BD Biosciences), 캘리포니아주 마운틴 뷰)를 사용하여 생산한다. IgG 항체를 단백질 G-세파로스 (아머샴 바이오사이언시스(Amersham Biosciences), 스웨덴 웁살라)에 걸친 흡수에 이어, 0.1 M 글리신-HCL (pH 2.7)로의 용리에 의해 정제한다. 산물을 포스페이트-완충 생리식염수에 대해 투석하고 센트리 플러스(Sentry Plus) 원심 여과기 장치 (밀리포어(Millipore), 매사추세츠주 베드포드)를 사용하여 농축시킨다. 대조군 시리아 햄스터 IgG를 잭슨 이뮤노리서치(Jackson ImmunoResearch) (펜실베니아주 웨스트 그로브)로부터 획득한다. rsMVA 역가를 벡타스테인 엘리트(VECTASTAIN Elite) ABC 키트 (벡터 래보래토리스(Vector Laboratories), 캘리포니아주 벌링게임)를 사용하는 면역염색 감염된 배양에 의해 결정한다. sMVA로부터 발현된 마우스 p53 단백질의 항원-특이적 검출은 항-p53 항체, pab122를 사용하고, 이어서 키트에 제공된 퍼옥시다제-표지된 염소 항-마우스 2차 항체와 함께 인큐베이션한다. CMV-pp65를 발현하는 대조군 sMVA를 또한 뮤린 sMVAp53의 구축에 사용된 것과 같이 동일한 기술을 사용하여 구축한다.Female 6-8-week-old BALB/C mice are obtained from Jackson Laboratory (Bar Harbor, MA) and maintained in a specific pathogen-free environment. All studies are approved by the Research Animal Care Committee of the City of Hope National Medical Center and are conducted under American Association for the Accreditation of Laboratory Animal Care guidelines. Meth A sarcoma cells (Meth A) are donated by Dr. LJ Old, Memorial Sloan-Kettering Cancer Center (New York, NY). Meth A is passaged as an ascites tumor. Anti-CTLA-4 (9H10) was donated by Dr. James Allison, MD Anderson Cancer Center (Houston, Texas). Antibodies are produced using a CELLine device (BD Biosciences, Mountain View, CA). IgG antibodies are purified by uptake over protein G-Sepharose (Amersham Biosciences, Uppsala, Sweden) followed by elution with 0.1 M glycine-HCL, pH 2.7. The product is dialyzed against phosphate-buffered saline and concentrated using a Sentry Plus centrifugal filter apparatus (Millipore, Bedford, MA). Control Syrian hamster IgG is obtained from Jackson ImmunoResearch (West Grove, PA). rsMVA titers are determined by immunostaining infected cultures using the VECTASTAIN Elite ABC kit (Vector Laboratories, Burlingame, CA). Antigen-specific detection of mouse p53 protein expressed from sMVA uses an anti-p53 antibody, pab122, followed by incubation with a peroxidase-labeled goat anti-mouse secondary antibody provided in the kit. Control sMVA expressing CMV-pp65 was also constructed using the same technique as used for construction of murine sMVAp53.
생체내 종양 챌린지 실험In vivo tumor challenge experiments
6주령 암컷 BALB/C 마우스에게 피하 경로에 의해 좌측 플랭크에 5x105개의 METH A 세포를 주사한다. 3일차에, 마우스를 복강내 주사로 5x107 pfu의 sMVAp53로 처리한다. 음성 대조군 마우스에게 5x107 pfu의 sMVApp65 또는 포스페이트 완충 염수를 주사한다. 추가적인 양성 대조군은 원래 보고서에 기재된 동일한 뮤린 MVAp53을 이용한다. 피하 종양을 매주 루시페라제 기술을 사용하는 IVIS 이미징 방법에 의해 또는 루시페라제 유전자가 METH A 육종 세포로 삽입되지 않은 경우 캘리퍼에 의해 평가한다. 추가적인 접근법은 sMVA 감염과 동일한 연령의 BALB/C 마우스에게 좌측 플랭크에 1X106개의 METH A 세포를 주사하는 것이다. 이 종양은 CTLA-4 (9H10) 항체 치료에도 불구하고 다수의 마우스에서 신속하게 치명적인 종양을 생산하는 것으로 나타난다. 종양 접종 후 7일에, 마우스에게 5x107 pfu의 sMVAp53을 복강내로 주사한다. 대조군은 상기 기재된 바와 동일하다. 항-CTLA-4 (9H10) 항체 또는 대조군 햄스터 항체를 종양 주사 후 6일, 9일, 및 12일에 각각 100, 50, 및 50 마이크로그램의 용량으로 복강내로 주사한다.6-week-old female BALB/C mice are injected with 5×10 5 METH A cells in the left flank by subcutaneous route. On
실시예 8: sMVA의 구축 및 시험관내 및 생체내 특징규명Example 8: Construction and characterization of sMVA in vitro and in vivo
도 1에 제시된 바와 같이 설계된 3개의 sMVA 단편은, 원형 DNA 플라스미드로서 헬퍼 바이러스 감염된 세포로 공동-형질감염될 때, 선형 미니염색체로 분해하고, 공유된 상동성 서열을 통해 서로 재조합할 수 있고, 궁극적으로 전장 MVA 게놈으로서 패키징된다. 3개의 sMVA 단편 모두를 박테리아 인공 염색체 (BAC) 클론으로서 이. 콜라이에 클로닝하였다.The three sMVA fragments designed as shown in Figure 1, when co-transfected into helper virus infected cells as circular DNA plasmids, can degrade into linear minichromosomes and recombine with each other via shared homologous sequences, and ultimately packaged as a full-length MVA genome. All three sMVA fragments were identified as bacterial artificial chromosome (BAC) clones in E. It was cloned into E. coli.
이전에 BAC로부터 MVA를 구하는 데 이용된 절차를 사용하여16,24,25, sMVA 바이러스를 계두 (FPV)에 비-허용성인 BHK 세포로의 3개의 DNA 플라스미드의 공동-형질감염 시 (도 2) 헬퍼 바이러스로서의 FPV를 사용하여 재구성하였다. 2개의 상이한 FPV 균주 (HP1.441 및 TROVAC)를 사용하여 sMVA 바이러스 재구성을 촉진하였다 (도 12A). 초정제된 sMVA 바이러스를 MVA 백신 생산에 통상적으로 사용되는 CEF에서의 바이러스 증식 후 생산하였다. 재구성된 sMVA 바이러스로 달성된 바이러스 역가는 야생형 MVA (wtMVA)로 달성된 바이러스 역가와 유사하였다 (하기 표 1). 16,24,25 , using the procedure previously used to obtain MVA from BAC, upon co-transfection of the three DNA plasmids into BHK cells that are non-permissive to fowlpox (FPV) with sMVA virus (Figure 2). Reconstituted using FPV as helper virus. Two different FPV strains (HP1.441 and TROVAC) were used to facilitate sMVA virus reconstitution ( FIG. 12A ). Ultra-purified sMVA virus was produced after viral propagation in CEF, which is commonly used for MVA vaccine production. The viral titers achieved with the reconstituted sMVA virus were similar to those achieved with wild-type MVA (wtMVA) (Table 1 below).
sMVA의 바이러스 DNA를 특징규명하기 위해, sMVA 및 wtMVA-감염된 CEF로부터의 DNA 추출물을 PCR에 의해 여러 MVA 게놈 위치에 대해 비교하였다. 유사한 PCR 결과를 sMVA 및 wtMVA로 F1/F2 및 F2/F3 재조합 부위를 포함하는 모든 평가된 게놈 위치에 대해 획득하였고 (도 11A), 이는 3개의 sMVA 단편의 효율적인 재조합을 나타낸다. 추가적인 PCR 분석은 sMVA 바이러스 DNA에서의 임의의 BAC 벡터 서열의 부재를 나타냈고 (도 11A), 이는 sMVA 바이러스 재구성 시 박테리아 벡터 요소의 자발적이고 효율적인 제거를 시사한다. 제한 효소 소화에 의한 초정제된 sMVA 및 wtMVA 바이러스로부터의 바이러스 DNA의 비교는 sMVA와 wtMVA 사이의 유사한 게놈 패턴을 밝혀냈다 (도 11B). sMVA 바이러스 DNA의 시퀀싱 분석은 F1/F2 및 F2/F3 재조합 부위를 포함하는 여러 위치에서 MVA 게놈 서열을 확인하였다. 더욱이, FPV TROVAC로 재구성된 sMVA 바이러스 단리물 중 하나의 전체 게놈 시퀀싱은 참조 MVA 게놈 서열의 조립 및 재구성된 sMVA 바이러스로부터 비롯한 바이러스 DNA에서의 벡터-특이적 서열의 부재를 확인하였다.To characterize the viral DNA of sMVA, DNA extracts from sMVA and wtMVA-infected CEFs were compared for several MVA genomic locations by PCR. Similar PCR results were obtained for all evaluated genomic positions containing F1/F2 and F2/F3 recombination sites with sMVA and wtMVA ( FIG. 11A ), indicating efficient recombination of the three sMVA fragments. Additional PCR analysis revealed the absence of any BAC vector sequences in the sMVA virus DNA ( FIG. 11A ), suggesting a spontaneous and efficient removal of bacterial vector elements upon sMVA virus reconstitution. Comparison of viral DNA from ultra-purified sMVA and wtMVA viruses by restriction enzyme digestion revealed similar genomic patterns between sMVA and wtMVA ( FIG. 11B ). Sequencing analysis of sMVA viral DNA confirmed the MVA genomic sequence at several locations, including F1/F2 and F2/F3 recombination sites. Moreover, whole genome sequencing of one of the sMVA virus isolates reconstituted with FPV TROVAC confirmed the assembly of the reference MVA genomic sequence and the absence of vector-specific sequences in the viral DNA, including from the reconstituted sMVA virus.
sMVA의 복제 특성을 특징규명하기 위해, sMVA 및 wtMVA의 성장 속도를 생산적인 MVA 복제를 지지하는 것으로 공지된 2종의 세포 유형인 BHK 및 CEF 세포 상에서 비교하였다4. 이 분석은 BHK 및 CEF 세포 둘 다에서 sMVA 및 wtMVA의 유사한 성장 속도를 밝혀냈다 (도 12B). 또한, 바이러스 포커스의 유사한 면적이 sMVA 또는 wtMVA로 감염된 BHK 및 CEF 세포 단층에서 결정되었고 (도 12C), 이는 MVA 허용성 세포에서 확산되는 sMVA 및 wtMVA의 유사한 능력을 시사한다. BHK 및 CEF 세포에서의 sMVA 및 wtMVA의 생산적인 복제와 비교하여4, 단지 제한된 바이러스 생산이 sMVA 또는 wtMVA로의 다양한 인간 세포주의 감염 후 관측되었다 (도 12D). 이들 결과는 MVA의 심각하게 제한된 복제 특성과 일치하고 sMVA 바이러스가 BHK 및 CEF 세포에서 효율적으로 증식할 수 있지만, 인간 세포에서는 효율적으로 증식할 수 없다는 것을 나타낸다.To characterize the replication properties of sMVA, the growth rates of sMVA and wtMVA were compared on BHK and CEF cells, two cell types known to support productive MVA replication 4 . This analysis revealed similar growth rates of sMVA and wtMVA in both BHK and CEF cells (Fig. 12B). In addition, similar areas of viral foci were determined in BHK and CEF cell monolayers infected with sMVA or wtMVA (Fig. 12C), suggesting a similar ability of sMVA and wtMVA to spread in MVA-permissive cells. Compared to the productive replication of sMVA and wtMVA in BHK and CEF cells 4 , only limited viral production was observed after infection of various human cell lines with sMVA or wtMVA ( FIG. 12D ). These results are consistent with the severely limited replication properties of MVA and indicate that the sMVA virus can efficiently proliferate in BHK and CEF cells, but not in human cells.
sMVA를 생체내 특징규명하기 위해, sMVA 및 wtMVA의 면역원성을 C57BL/6 마우스에서 높은 또는 낮은 용량으로 2회의 면역화 후 비교하였다. 제1 및 제2 면역화 후 sMVA 및 wtMVA에 의해 자극된 MVA-특이적 결합 항체는 비교할 만하였다 (도 13A, 14A). 높은 용량 백신 그룹의 항체 수준은 제1 면역화 후 낮은 용량 백신 그룹의 것을 초과하였지만, 높은 및 낮은 용량 백신 그룹에서 유사한 항체 수준이 제2 면역화 후 관측되었다. 또한, 제2 면역화 후 sMVA 및 wtMVA에 의해 유도된 MVA-특이적 NAb 반응의 수준에서 유의한 차이가 검출되지 않았다 (도 13B, 14B). 부스터 면역화 후 면역우세 펩티드를 사용하는 생체외 항원 자극에 의해 결정된 MVA-특이적 T 세포 반응은47 sMVA 또는 wtMVA를 받은 마우스에서 유사한 MVA-특이적 T 세포 수준을 밝혀냈다 (도 13C-13D 및 14C-14D). 이들 결과는 sMVA 바이러스가 마우스에서의 MVA-특이적 체액성 및 세포성 면역의 유도에서 wtMVA와 유사한 능력을 갖는다는 것을 나타낸다.To characterize sMVA in vivo, the immunogenicity of sMVA and wtMVA was compared after two immunizations at high or low doses in C57BL/6 mice. MVA-specific binding antibodies stimulated by sMVA and wtMVA after the first and second immunizations were comparable ( FIGS. 13A, 14A ). Antibody levels in the high dose vaccine group exceeded those of the low dose vaccine group after the first immunization, but similar antibody levels in the high and low dose vaccine groups were observed after the second immunization. In addition, no significant difference was detected in the level of MVA-specific NAb responses induced by sMVA and wtMVA after the second immunization ( FIGS. 13B, 14B ). MVA-specific T cell responses determined by ex vivo antigen stimulation with immunodominant peptides after booster immunization revealed similar MVA-specific T cell levels in mice receiving either 47 sMVA or wtMVA ( FIGS. 13C-13D and 14C- 14D). These results indicate that the sMVA virus has a similar ability to wtMVA in the induction of MVA-specific humoral and cellular immunity in mice.
참고문헌references
하기 열거된 참고문헌, 특허 및 공개된 특허 출원, 및 상기 명세서에 인용된 모든 참고문헌은 본원에 완전히 명시된 바와 같이 그 전문이 본원에 참조로서 포함된다.The references listed below, patents and published patent applications, and all references cited in the above specification are hereby incorporated by reference in their entirety as if fully set forth herein.
SEQUENCE LISTING
<110> CITY OF HOPE
<120> POXVIRUS-BASED VECTORS PRODUCED BY NATURAL OR SYNTHETIC DNA AND
USES THEREOF
<130> 054435-8200.WO00
<150> US 62/969,628
<151> 2020-02-03
<150> US 63/113,803
<151> 2020-11-13
<160> 18
<170> PatentIn version 3.5
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aaagaggttt aatatttttg tgagaccatc gaaggagaaa gagataaaac ttttttacga 360
ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac 420
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aaggagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 600
agaccatcga aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat 660
atttttgtga gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag 720
aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 780
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ttacgactcc atcagaaaga ggtttaatat ttttgtgaga ccatcgaaga gagaaagaga 900
ataaaaatat tttagtgaca ccatcagaaa gaggtttaat atttttgtga gaccatcgaa 960
gagagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 1020
gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag aggtttaata 1080
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aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 1200
catcagaaag accatcgaag agagaaagag aaagagatag ttagtctaga tatttttctt 1260
agtacaaaag tcaatgtttt aaaatatatg gacaagaatt tgtctgtata aaaacttgtg 1320
tgaaattttg taccaaagaa aaaatgtgag cagtatcccc tacatggatt ttactagatc 1380
atttatatac caaaaaatat tatacgatct acgttttatt atatgatttt aacgtgtaaa 1440
ttataaacat tattttatga tatacaattg tctggtaacc tagatgggca taggggatga 1500
gtatatgttg ttggacgtta ttgtttaaga aatagttgat gcatcagaaa gaggtttaat 1560
atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttacgact ccatcagaaa 1620
gaggtttaat atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttatgact 1680
ccattgaaga gagaatgaga ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1740
attttttatg agaccatcaa agagagaaag agaataaaaa tattttatga ctccattgaa 1800
gagagaaaga gaaaatgaga ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1860
attttttatg agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt 1920
tatgagacca tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag 1980
accatcaaag agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc 2040
aaagagagaa agagaataaa aatatttttg taaaactttt tttatgagac catcaaagag 2100
agaaagagaa taaaaatatt tttgtaaaac tttttttatg agaccatcaa agagagaaag 2160
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aaaatatttt tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata 2280
ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca ccatcagaaa 2340
gaggtttaat atttttgtga gaccatcgaa gagagaaaga gaataaaaat attttatgac 2400
tccattgaag agagaaagag aataaaaata ttttagtgac accatcagaa agaggtttaa 2460
tattttttat gagaccatca aagagagaaa gagaataaaa atatttttgt aaaacttttt 2520
ttatgagacc atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga 2580
gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 2640
caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 2700
gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 2760
gagaataaaa atattttatg actccattga agagagaatg agaataaaaa tattttagtg 2820
acaccatcag aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa 2880
aatattttat gactccattg aagagagaaa gagaataaaa atattttagt gacaccatca 2940
gaaagaggtt taatattttt tatgagacca tcaaagagag aaagagaata aaaatatttt 3000
tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 3060
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tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 3180
agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 3240
tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag accatcaaag 3300
agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc aaagagagaa 3360
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aaatatttta tgactccatt gaagagagaa tgagaataaa aatattttag tgacaccatc 3540
agaaagaggt ttaatatttt ttatgagacc atcaaagaga gaaagagaat aaaaatattt 3600
ttgtaaaact ttttttatga gaccatcaaa gagagaaaga gaataaaaat atttttgtaa 3660
aaattataaa cattatttta tgatatacaa ttgtctggta acctagatgg gcatagggga 3720
tgttgataag ctcgacgagt atatgttgtt ggacgttatt gtttaagaaa tagttgatgc 3780
atcagaaaga gaataaaaaa tattttagtg agaccatcga agagagaaag agataaaact 3840
tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 3900
agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 3960
aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 4020
gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 4080
caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 4140
gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 4200
gagaataaaa atatttttgt aaaacttttt ttatgagacc atcaaagaga gaaagagaat 4260
aaaaatattt tatgactcca ttgaagagag aatgagaata aaaatatttt agtgacacca 4320
tcagaaagag gtttaatatt tttgtgagac catcgaagag agaaagagaa taaaaatatt 4380
ttatgactcc attgaagaga gaatgagaat aaaaatattt tagtgacacc atcagaaaga 4440
ggtttaatat tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 4500
acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 4560
tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 4620
agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 4680
tcaaagagag aaagagaata aaaatatttt atgactccat tgaagagaga atgagaataa 4740
aaatatttta gtgacaccat cagaaagagg tttaatattt ttgtgagacc atcgaagaga 4800
gaaagagaat aaaaatattt tatgactcca ttgaagagag aaagagaata aaaatatttt 4860
agtgacacca tcagaaagag gtttaatatt ttttatgaga ccatcaaaga gagaaagaga 4920
ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa gagaataaaa 4980
atattttatg actccattga agagagaatg agaataaaaa tattttagtg acaccatcag 5040
aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa aatattttat 5100
gactccattg aagagagaat gagaataaaa atattttagt gacaccatca gaaagaggtt 5160
taatattttt gtgagaccat cgaagagaga aagagaataa aaatatttta tgactccatt 5220
gaagagagaa tgagaataaa aatattttag tgacaccatc agaaagaggt ttaatatttt 5280
ttatgagacc atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga 5340
gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 5400
caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 5460
gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat 5520
ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga 5580
gagaaagaga ataaaaatat tttatgactc cattgaagag agaaagagaa taaaaatatt 5640
ttagtgacac catcagaaag aggtttaata tttttgtgag accatcgaag agagaaagag 5700
aataaaaata ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca 5760
ccatcagaaa gaggtttaat attttttatg agaccatcaa agagagaaag agaataaaaa 5820
tattttttat gagaccatca aagagagaaa gagaataaaa atattttatg agaccatcaa 5880
agagagaaag agaataaaaa tattttttat gagaccatca aagagagaaa gagaataaaa 5940
atattttatg agaccatcaa agagagaaag agaataaaaa tattttttat gagaccatca 6000
aagagagaaa gagaataaaa atatttttgt atgagaccat cagaaagagg tttaatattt 6060
ttgtgatacc ctgaaaggaa ataggaatag tgtcataatc gtatcacact attgagacag 6120
aaaaagaaga agtcgcgaga ggtaactttt tgttttgcaa accggaatat agtgtccggt 6180
acactttttt aattcgtggt gtgcctgaat cgttcgatta accctactca tccaatttca 6240
gatgaataga gttatcgatt cagacacacg ctttgagttt tgttgaatcg atgagtgaag 6300
tatcatcggt tgcaccttca gatgccgatc cgtcgacata cttgacctca agttcagatg 6360
attccttgca catgtctccg atacgaacgc taaactctag attcttgaca cattttgtat 6420
cgacgatcgt tgaaccgatg atatcttcgt aactcacttt cttatgagag atgttagacc 6480
cgagtactgg atgggtcttg atgtcgctgt ctttctcttc ttcgctacat ctgatgtcga 6540
tagacacctc acagtctttc catcagcgga ttctgagatg gatttaatct gaggacattt 6600
ggtgaatcca aagttcattc tcagacctcc accgatgatg gagtaataag tggtaggagg 6660
atctacatcc tcgactgatt ccacctcggg atctggatct gactcggact ctgtaatttc 6720
cgttacggat tggcaaatct tatcatcggt cggtgtttgg tcttgctttg tgactttgat 6780
aataacatcg attcccatat gatgtttgtt ttcttcttcc gtacacgatg aggatgattg 6840
ctgaagactg gcaggcacat gcatgccagt acgatatatt gtttcatgat tgctattgat 6900
tgagtactgt tctttatgat tctacttcct taccgtgcaa taaattagaa tatattttct 6960
acttttacga gaaattaatt attgtattta tgggtgaaaa acttactata aaaagcgggt 7020
gggtttggaa ttagtgatca gtttatgtat atcgcaacta ccgggcatat ggctacatta 7080
cccacatgat aagagattgt atcagtttcg tagtcttgag tattggtatt actatatagt 7140
atatagatgt cgacgctaga gttactgtct ccgaatgcgg catgatagta tcattctttg 7200
ctttcgttaa ctgtttggag gaagaatctt tgttattgca tttaatctcg aaattcagag 7260
tgcacacctt tctcctgtaa agaaacctga agtcgctacc ttattaagaa gacgggatcg 7320
cagtctttat gattcatagt aatagttagt tccgacgttg agatggattc gctgagaccg 7380
gtagtggtcg tccgagtaca cgatgtgtcg ttaactggat acaggttaat ttccacatcg 7440
atatagttaa aggtatttct gggtacgggt tcgcatttat ctgcggaaga gacggtgtga 7500
gaatatgttc cgagaccaca cggagaacag atgacgtctc cggatactcc gtatcctatt 7560
ccacattttg tttgggaaac acatgccttg catccatgat cgggagagca ttcacagatt 7620
ctattgtgag tcgtgttaca cgatcgcgtc gacattgttg acagaaacgt gaccttcatt 7680
cttaccgtcg tccataaata cgttaggtat gtaccacata ctgtcgcgaa cgatgcgtcc 7740
atctcataat gatttacttt ttcataatta aagatgtgaa agaaaaccga acaatatatt 7800
tttttagtaa tgtttatgcg agacatataa aataaactcc gtgtttatga tgccggtaaa 7860
tgtttttatc atcttggacg gaatcgattt tgtaatatgc catggaaaca ggacattatc 7920
actccatgat aaattattta atggagtcga tcctctcatt gttctttgcg tatctcaatc 7980
tgtggcgttt gcttcgttta aataatatat caaacatgga gacgcctgat atgtaggcat 8040
tcttcattct attaatgtct gctctatagc gctttagttc cttatgacga ccggcgatat 8100
catacttact ttagaaggaa aatcatcatc taggattaag gcgtatctga tacaggcgaa 8160
taatggttca ggatatagat agcgtatatc tctattaaat gcgtcaatca tagtctctag 8220
agtgggatgg taactcagta ataaatcaac tagcttctct ttggtaactg cttttctgga 8280
tggccgtatt gattatcgag cgtgacactc gctccatatt ccaataaccg ctttgcaaat 8340
tgtatattat tgacatcgac cgcgtaatat agtagagtta tcgatcatat ctatatcatc 8400
catgtacttg cttagtatat caaatacatc ttcataacag tgatacccgc aattattaaa 8460
tctcgataat atcagaccgt acatacatag acggccattg ttagatatgt gatttacagc 8520
cgcgtgtcca tattttccac gataaacctt acgacgttta catcgacgag attattatta 8580
acaaagttgt tgtccgtcgt cttatccaac atgcattgaa tgataggtat acttaccata 8640
tcgccgtaat gtaagtagtt tatcagtatg gcttgtacga tggattcatc ctgttgtcta 8700
aatctcttta gaatgttatc gatgatgtag tggttatatt ctctggaatc gtacgaagta 8760
atactacgca ttacgtcgac aagagtatga cgtctctcaa taagaagatt aacgatttcc 8820
atgtctacat tatatggggt tactctaaat cgcttgttta gataatacgc ctctaatata 8880
gggctgacgt cgtatactct acacgtgtcc acatccttta ttaataatct ctatatctat 8940
ggttgagcaa gaccagtagt attggatgga aacattgtta tcgatcaaac atttaattac 9000
atccttggat agagattctc tatgagacga tatatagtaa tgaagagagt tcttacacat 9060
atcactgttg tacatacagg tacgaaatac gtaaccggtg ctgtaacatt ctgatttaag 9120
aagccatagc aatacttctg gtctcggatt aggcgtcgtt acgtatatat ccaccaatcc 9180
gagaccattg attgcataat tcgtattctt ggacggacgt atccgtttat ccacaattag 9240
gtattttagc agacgtaagt cgaaatcatt tatattcgac ttgagttcgt tagaggaatt 9300
cgaatagctg gatatcagta gatgcacaat ctgagatttt acgtatctat gcttactgta 9360
tgctcctagc ggagttaatc cttcgttgtt tctacaaagt ctctcgactc cgcgagagag 9420
taacagtcga acaatcttaa tgtctgtatc gcatttattg gagacgtaac aatgtagcgc 9480
attgtttcct cgtctatcta tatgttttga taagttgtga cacgtttcaa tttctagttt 9540
tatttttttg tacgtcacat cttcatccag tagacgacat agaatacatg tgcaatccat 9600
agctattctg gtgctaatta ttcctcataa gatgataaaa agtgtagtga gagagcatga 9660
aggagattta gtatttagca gtgcggatat gatccaagag ggtgagatag tcgttctcgt 9720
tcagaatctt tcgcagcata agtagtatgt cgatatactt atcgttgaag actcttccag 9780
agacgatagc tgattgagta caaagtccaa tgattgcacg aagttcttcg gcggttttca 9840
tggagtcatt tctgatgaaa catttaatga tctaaatttc agtttatgtt tgtaccccgt 9900
attcatactt aacaaattgg tattacatac cattaataat gcaagcataa aaaatcgtta 9960
gtagatgttt ctaaatatag gttccgtaag caaagaatat aagaatgaag cggtaatgat 10020
aaaatcaatc gttatctaaa atgatcatac tcatttattt tattctatta tattaacaca 10080
tacattttta acagcaacac attcaatatt gtattgttat ttttatatta tttacacaat 10140
taacaatata ttattagttt atattactga attaataata taaaattccc aatcttgtca 10200
taaacacaca ctgagaaaca gcataaacac aaaatccatc aaaaatgttg ataaattatc 10260
tgatgttgtt gttcgctgct atgataatca gatcattcgc cgatagtggt aacgctatcg 10320
aaacgacatc gccagaaatt acaaacgcta caacagatat tccagctatc agattatgcg 10380
gtccagaggg agatggatat tgtttacacg gtgactgtat ccacgctaga gatatcgacg 10440
gtatgtattg tagatgctct catggttata caggcattag atgtcagcat gtagtattag 10500
tagactatca acgttcagaa aaaccaaaca ctacaacgtc atatatccca tctcccggta 10560
ttatgcttgt attagtaggc attattatta ttacgtgttg tctattatct gtttataggt 10620
tcactcgacg aactaaacta cctatacaag atatggttgt gccataattt ttataaattt 10680
tttttatgag tatttttaca aaaatgtata aagtgtatgt cttatgtata tttataaaaa 10740
tgctaaatat gcgatgtatc tatgttattt gtatttatct aaacaatacc tctacctcta 10800
gatattatac aaaaattttt tatttcggca tattaaagta aaatctagtt accttgaaaa 10860
tgaatacagt gggtggttcc gtatcaccag taagaacata atagtcgaat acagtatccg 10920
attgagattt tgcatacaat actagtctag aaagaaattt gtaatcatct tctgtgacgg 10980
gagtccatat atctgtatca tcgtcccatg ctatattcct gttatcatca ttagttaatg 11040
aaaataactc tcgtgcttca gaaaagtcaa atattgtatc catacataca tctccaaaac 11100
tatcgcttat acgtttatct ttaacgatac ctatacctag atggttattt actaacagac 11160
attttccaga tctattgact ataactccta tagtttccac atcaaccaag taatgatcat 11220
ctattgttat ataacaataa cataactctt ttccgttttt atcagtatgt atatctatat 11280
caacgtcgtc gttgtagtga atagtagtca ttgatctatt atatgaaacg gatatgtcta 11340
gaacggcaat tgttttacgt ccagttaaca ctttcgttga tttaaagtct agagtctttg 11400
caaacataat atccttatcc gactttatat ttcctgtagg gtggtataat tttattttgc 11460
ctccacatat cggtgtttcc aaatatatta ctagacaata ttccatatag ttattagtta 11520
agggtaccca attagaacac gtacgcttat tatcatcatt tggatcgtat ttcataaaag 11580
ttattgtact atcgatgtca acacattcta cattttttaa tcgtctatat agtatttttc 11640
tgatattttc tataatatca gaattgtctt ccatcggaag ttgtatacta tcggaatcag 11700
ttacatgttt aaataattct ctgatgtcat tccttataca atcaaattca ttattaaaca 11760
gtttaatagt ctgtagacct ttatcgtcgt aaatatccat tgtcttatta gttacgctta 11820
tttttatgtg tttttacgtt gctttattat attttataag aatgattgtt tgacgaatca 11880
cgagaactat taagacacat tattaggtat atattataaa aaagtttttg attacgatgt 11940
tataagagga aagaggacac attaacatca tacatcaatt aactacattc ttataacatc 12000
gtaatcaaaa gaattgcaat tttgatgtat aacaactgtc aatgggttat ggaattgtat 12060
attacatatt atacggtatg ttggtaacga caaataccga tcggtaattg tctgccggtg 12120
taatagaatt atatatatct atctattaca ccggccttgt atacataata ataagttgtg 12180
gtagtatgat ctccatattt ataatttagg actttgtatt cagttttttt ggaatcataa 12240
aaaataaaaa aaagttttac taatttaaaa ttatttacat ttttttcact gtttagtcgc 12300
ggatatggaa ttcgatcctg ccaaaatcaa tacatcatct atagatcatg taacaatatt 12360
acaatacata gatgaaccaa atgatataag actaacagta tgcattatca caaaaataaa 12420
tccacatttg gctaatcaat ttcgggcttg gaaaaaacgt atcgccggaa gggactatat 12480
gactaactta tctagagata caggaataca acaatcaaaa cttactgaaa ctgtcaaaaa 12540
aatagaaaca tatatggtct atatatacac tacaatttag ttattaattg gataaccgat 12600
gtgattatca atcaatatta agaaggttgg taaattggta catagctaat aatacctata 12660
cacccaataa tacaacaacc atttctgagt tggatatcat caaaatactg gataaatacg 12720
aggacgtgta tagagtaagt aaagaaaaag aatgtgaaat ttgctatgaa gttgtttact 12780
caaaacgata gatactttgg tttattggat tcgtgtaatc atatattttg cataacatgc 12840
atcaatatat ggcatagaac acgaagagaa accggtgcgt cggataattg tcctatatgt 12900
cgtacccgtt ttagaaacat aacaatgagc aagttaacta ataaataaaa agtttaattt 12960
gttgacgacg tatgtcgtta ttttttctcg tataaaagat taatttgatt ctaatataat 13020
ctttagtatt ggataaatat caattcaaat taattccatt agattatatc ataaataaaa 13080
atagtagcac gcactacttc agccaaatat tcttttttga aacgccatct atcgtagtga 13140
ggacacaagt gaacctataa tgagcaaatt tattagtatc ggttacatga aggactttac 13200
gtagagtggt gattccacta tctgtggtac gaacggtttc atcttctttg atgccatcac 13260
ccagatgttc tataaacttg gtatcctttg ccaaccaata catatagcta aactcaggca 13320
tatgttccac acatcctgaa caatgaaatt ctccagaaga tgttacaatg tctagatttg 13380
gacatttggt ttcaaccgcg ttaacatatg agtgaacaca cccatacatg aaagcgatga 13440
gaaataggat tttcatcttg ccaaaatatc actagaaaaa atttatttat caattttaaa 13500
ggtataaaaa atacttattg ttgctcgaat attttgtatt tgatggtata cggaagatta 13560
gaaatgtagg tattatcatc aactgattct atggttttat gtattctatc atgtttcact 13620
attgcgttgg aaataatatc atatgcttcc acatatattt tattttgttt taactcataa 13680
tactcacgta attctggatt attgacatat ctatgaataa ttttagctcc atgatcagta 13740
aatattaatg agaacatagt attaccacct accattattt ttttcatctc attcaattct 13800
taattgcaaa gatctatata atcattatag cgttgactta tggactctgg aatcttagac 13860
gatgtacagt catctataat catggcatat ttaatacatt gttttatagc atagtcgtta 13920
tctacgatgt tagatatttc tctcaatgaa tcaatcacac aatctaatgt aggtttatga 13980
cataatagca ttttcagcag ttcaatgttt ttagattcgt tgatggcaat ggctatacat 14040
gtatatccgt tatttgatct aatgttgaca tctgaaccgg attctagcag taaagatact 14100
agagattgtt tattatatct aacagccttg tgaagaagtg tttctcctcg tttgtcaatc 14160
atgttaatgt ctttaagata aggtaggcaa atgtttatag tactaagaat tgggcaagca 14220
taagacatgt cacaaagacc ctttttgtat gtataagtgt aaaaattata acattcatag 14280
ttggatttac ataggtgtcc aatcgggatc tctccatcat cgagataatt gatggcatct 14340
cccttccttt tttagtagat atttcatcgt gtaagaatca atattaatat ttctaaagta 14400
tccgtgtata gcctctttat ttaccacagt tccatattcc actagaggga tatcgccgaa 14460
tgtcatatac tcaattagta tatgttggag gacatccgag ttcattgttt tcaatatcaa 14520
aaagatggtt tccttatcat ttctccatag tggtacaata ctacacatta ttccgtgcgg 14580
ctttccattt tccaaaaaca atttgaccaa atctacatct ttattgtatc tataatcact 14640
atttagataa tcagccataa ttactcgagt gcaacatgtt agatcgtcta tatatgaata 14700
agccgtgtta tctattcctt tcattaacaa tttaacgatg tctatatcta tatgagatga 14760
cttaatataa tattgaagag ctgtacaata gtttttatct ataaaagacg gcttgattcc 14820
gtgattaatt agacatttaa caacttccgg acgcacatat gctctcgtat ccgactctga 14880
atacagatga gagatgatat acagatgcaa tacggtaccg caatttcgta gttgataatc 14940
atcatacgcg tatcagtact cgtcctcata aagaacactg cagccatttt ctatgaacaa 15000
atcaataatt tcaggaacag gatcatctgt cattacataa ttttctataa ctgaacgatg 15060
gttttcacat ttaacactca agtcaaatcc atgttctacc aacaccttta tcaagtcaac 15120
gtctacattt ttggatttca tatagctgaa tatattaaag tcatttatgt tgctaaatcc 15180
agtggcttct agtagagcca tcgctatatc ctttaacttt aacatgtcta ctatttgtgt 15240
attcttctaa tggggtagct gtctccaatt tttgcgtaat ggattagtgc cactgtctag 15300
tagtagtttg acgacctcga cattattaca atgctcatta aaaaggtatg cgtgtaaagc 15360
attattcttg aattggttcc tggtatcatt aggatctctg tctctcaaca tctgtttaag 15420
ttcatcgaga gccacctcct cattttccaa atagtcaaac attttgactg aatgagctac 15480
tgtgaactct atacacccac acaactaatg tcattaaata tcatgtcaaa aacttgtaca 15540
attattaata aaaataattt agtgtttaaa ttttaccagt tccagatttt acacctccgt 15600
taaccccact ttttacacca ctggacgatc ctcctcccca cattccaccg ccaccagatg 15660
tataagtttt agatccttta ttactaccat catgtccatg gataaagaca ctccacatgc 15720
cgccactacc ccctttagaa gacatattaa taagacttaa ggacaagttt aacaataaaa 15780
ttaatcacga gtaccctact accaacctac actattatat gattatagtt tctattttta 15840
cagtacctta actaaagtct ctagtcacaa gagcaatact accaacctac actattatat 15900
gattatagtt tctattttta taggaacgcg tacgagaaaa tcaaatgtct aatttctaac 15960
ggtagtgttg ataaacgatt atcgtcaatg gatacctcct ctatcatgtc gtctattttc 16020
ttactttgtt ctattaactt attagcatta tatattattt gattataaaa cttatattgc 16080
ttattagccc aatctgtaaa tatcggatta ttaacatatc gtttctttgt aggtttattt 16140
aacatgtaca tcactgtaag catgtccgta ccatttattt taatttgacg catatccgca 16200
atttcttttt cgcagtcggt tataaattct atatatgatg gatacatgct acatgtgtac 16260
ttataatcga ctaatatgaa gtacttgata catattttca gtaacgattt attattacca 16320
cctatgaata agtacctgtg atcgtctagg taatcaactg ttttcttaat acattcgatg 16380
gttggtaatt tactcagaat aatttccaat atcttaatat ataattctgc tatttctggg 16440
atatatttat ctgccagtat aacacaaata gtaatacatg taaacccata ttttgttatt 16500
atattaatgt ctgcgccatt atctattaac cattctacta ggctgacact atgcgactta 16560
atacaatgat aaagtatact acatccatgt ttatatcatc aatatacggc ttacaaagtt 16620
ttagtatcga taacacatcc aactcacgca tagagaaggt agggaataat ggcataatat 16680
ttattaggtt atcatcattg tcattatcta caactaagtt tccatttttt aaaatatact 16740
cgacaacttt aggatctcta ttgccaaatt tttgaaaata tttatttata tgcttaaatc 16800
tatataatgt agctccttca tcaatcatac atttaataac attgatgtat actgtatgat 16860
aagatacata ttctaacaat agatcttgta tagaatctgt atatctttta agaattgtgg 16920
atattattac gtaaactatt acacaattct aaaatataaa acgtatcacg gtcgaataat 16980
agttgatcaa ctatataatt atcgattttg tgatttttct tcctaaactg tttacgtaaa 17040
tagttagata gaatattcat tagttcatga ccactatagt tactatcgaa taacgcgtca 17100
aatatttccc gtttaatatc gcatttgtca agataataat agagtgtggt atgttcacga 17160
taagtataat aacgcatctc tttttcgtgt gaaattaaat agtttattac gtccaaagat 17220
gtagcataac catcttgtga cctagtaata atataataat agagaactgt tttacccatt 17280
ctatcatcat aatcagtggt gtagtcgtaa tcgtaattgt ctaattcatc atcccaatta 17340
taatattcac cagcacgtct aatctgttct attttgatct tgtatccata ctgtatgttg 17400
ctacatgtag gtattccttt atccaataat agtttaaaca catctacatt gggatttgat 17460
gttgtagcgt atttttctac aatattaata ccatttttga tactatttat ttctatacct 17520
ttcgaaatta gtaatttcaa taagtctata tcgatgttat cagaacatag atattcgagt 17580
atatcaaaat cattgatatt tttatagtcg actgacgaca ataacaaaat cacaacatcg 17640
tttttgatat tattattttt cttggtaacg tatgccttta atggagtttc accatcatac 17700
tcatataatg gatttgcacc actttctatc aatgattgtg cactgctggc atcgatgtta 17760
aatgttttac aactatcata gagtatctta tcgttaacca tgattggttg ttgatgctat 17820
cgcatttttt ggtttctttc atttcagtta tgtatggatt tagcacgttt gggaagcatg 17880
agctcatatg atttcagtac tgtagtgtca gtactattag tttcaataag atcaatctct 17940
agatctatag aatcaaaaca cgataggtca gaagataatg aatatctgta ggcttcttgt 18000
tgtactgtaa cttctcgttt tgttagatgt ttgcatcgtg ctttaacatc aatggtacaa 18060
attttatcct cgctttgtgt atcatattcg tccctactat aaaattgtat attcagatta 18120
tcatgagatg tgtatacgct aacggtatca ataaacggag cacaccattt agtcataacc 18180
gtaatccaaa aatttttaaa gtatatctta acgaaagaag ttgtgtcatt gtctacggtg 18240
tatggtacta gatcctcata agtgtatata tctagagtaa tgtttaattt atcaaatggt 18300
tgataatatg gatcctcatg acaatttccg aagatggaaa tgagatatag acatgcaata 18360
aatctaattg cggacatggt tactccttaa aaaaatacga ataatcacct tggctattta 18420
gtaagtgtca tttaacacta tactcatatt aatccatgga ctcataatct ctatacggga 18480
ttaacggatg ttctatatac ggggatgagt agttttcttc tttaacttta tactttttac 18540
taatcatatt tagactgatg tatgggtaat agtgtttaaa gagttcgttc tcatcatcag 18600
aataaatcaa tatctctgtt tttttgttat acagatgtat tacagcctca tatattacgt 18660
aatagaacgt gtcatctacc ttattaactt tcaccgcata gttgtttgca aatacggtta 18720
atcctttgac ctcgtcgatt tccgaccaat ctgggcgtat aatgaatcta aactttaatt 18780
tcttgtaatc attcgaaata atttttagtt tgcatccgta gttatcccct ttatgtaact 18840
gtaaatttct caacgcgata tctccattaa taatgatgtc gaattcgtgc tgtataccca 18900
tactgaatgg atgaacgaat accgacggcg ttaatagtaa tttacttttt catctttaca 18960
tattgggtac tagttttact atcataagtt tataaattcc acaagctact atggaataag 19020
ccaaccatct tagtataaca cacatgtctt aaagtttatt aattaattac atgttgtttt 19080
atatatcgct acgaatttaa acagagaaat cagtttagga aaaaaaaata tctatctaca 19140
tcatcacgtc tctgtattct acgatagagt gctactttaa gatgagacat atccgtgtca 19200
tcaaaaatat actccattaa aatgattatt ccggcagcga acttgatatt ggatatatca 19260
caacctttgt taatatctac gacaatagac agcagtccca tggttccata aacagtgagt 19320
ttatctttct ttgaagagat attttgtaga gatcttataa aactgtcgaa tgacatcgca 19380
tttatatctt tagctaaatc gtatatgtta ccatcgtaat atctaaccgc gtctatctta 19440
aacgtttcca tcgctttaaa gacgtttccg atagatggtc tcatttcatc agtcatactg 19500
agccaacaaa tataatcgtg tataacatct ttgatagaat cagactctaa agaaaacgaa 19560
tcggctttat tatacgcatt catgataaac ttaatgaaaa atgtttttcg ttgtttaagt 19620
tggatgaata gtatgtctta ataattgtta ttatttcatt aattaatatt tagtaacgag 19680
tacactctat aaaaacgaga atgacataac tagttatcaa agtgtctagg acgcgtaatt 19740
ttcatatggt atagatcctg taagcattgt ctgtattctg gagctatttt ctctatatct 19800
aatttctgaa cgttcaccaa tgtctctagc cactttggca ctaatagcga tcattcgctt 19860
agcgtcttct atattattaa ctggttgatt caatctatct agcaatggac cgtcggacag 19920
cgtcattctc atgttcttaa tcaatgtaca tacatcgccg tcatctacca attcatccaa 19980
caacataagc tttttaaaat catcattata ataggtttga tcgttgtcat ttctccaaag 20040
aatatatcta ataagtagag tcctcatgat tagttaacaa ctatttttta tgttaaatca 20100
attagtacac cgctatgttt aatacttatt catattttag tttttaggat tgagaatcaa 20160
tacaaaaatt aatgcatcat taattttaga aatacttagt ttccacgtag tcaatgaaac 20220
atttgaactc atcgtacagg acgttctcgt acaggacgta actataaacc ggtttatatt 20280
tgttcaagat agatacaaat ccgataactt tttttacgaa ttctacggga tccactttaa 20340
aagtgtcata ccgggttctt tttatttttt taaacagatt aatggtgtga tgttgattag 20400
gtcttttacg aatttgatat agaatagcgt ttacatattc tccataatgg tcaatcgcca 20460
tttgttcgta tgtcataaat tctttaatta tatgacactg tgtattattt agttcatcct 20520
tgttcatcat taggaatcta tccaatatgg caattatact agaactatag gtgcgttgta 20580
tacacatatt gatgtgtctg tttatacaat ccatgctact accttcgggt aaaattgtag 20640
catcatatac catttctagt actttaggtt cattgttatc cattgcagag gacgtcatga 20700
tcgcatccta aaaaaatata ttatttttat gttattttgt taaaaataat catcgaatac 20760
gaatcatcca gtccactgaa tagcaaaatc tttactattt tggtatcttc caatgtggct 20820
gcctgatgta atggaaattc attctctaga agatttttca atgctccagc gttcaacaac 20880
gtacatacta gacgcacgtt attatcagct attgcataat acaaggcact atgtccatgg 20940
acatccgcct taaatgcatc tttgctagag agaaagcttt tcagctgctt agacttccaa 21000
gtattaattc gtgacagatc catgtctgaa acgagacgct aattagtgta taatttttgt 21060
catattgcac cagaattaat aatatctcta atagatctga ttagtagata catggctatc 21120
gcaaaacaac atatacacat ttaataaaaa taatatttat taagaaaatt cagatttcac 21180
gtacccatca atataaataa aataatgatt ccttacaccg tacccatatt aaggagattc 21240
taccttaccc ataaacaata taaatccagt aatatcatgt ctgatgatga acacaaatgg 21300
tgtattaaat tccagttttt caggagatga tctcgccgta gctaccataa tagtagatgc 21360
ctctgctaca gttccttgtt cgtcgacatc tatctttgca ttctgaaaca ttttataaat 21420
atataatggg tccctagtca tatgtttaaa cgacgcatta tctggattaa acatactagg 21480
agccatcatt tcggctatcg acttaatatc cctcttattt tcgatagaaa atttagggag 21540
tttaagattg tacactttat tccctaattg aaacgaccaa tagtctaatt ttgcagccgt 21600
aatagaatct gtgaaatggg tcatattatc acctattgcc aggtacatac taatattagc 21660
atccttatac ggaaggcgta ccatgtcata ttctttgtca tcgattgtga ttgtatttcc 21720
ttgcaattta gtaactacgt tcatcatggg aaccgttttc gtaccgtact tattagtaaa 21780
actagcattg cgtgttttag tgatatcaaa cggatattgc catatacctt taaaatatat 21840
agtattaatg attgcccata gagtattatt gtcgagcata ttagaatcta ctacattaga 21900
cataccggat ctacgttcta ctatagaatt aattttatta accgcatctc gtctaaagtt 21960
taatctatat aggccgaatc tatgatattg ttgataatac gacggtttaa tacacacagt 22020
attatctacg aaactttgat aagttagatc agtgtacgta tatttagatg ttttcagctt 22080
agctaatcct gatattaatt ctgtaaatgc tggacccaga tctctttttc tcaaatccat 22140
agtcttcaat aattctattc tagtattacc tgatgcaggc aatagcgaca taaacataga 22200
aaacgaataa ccaaacggtg agaagacaat attatcatct tgaatatttt tatacgctac 22260
tataccggca ttggtaaatc cttgtagacg ataggtagac gctgaacacg ttaacgatag 22320
tatcaataac gcaatcatga ttttatggta ttaataatta accttatttt tatgttcggt 22380
ataaaaatta ttgatgtcta cacatccttt tgtaattgac atctatatat ccttttgtat 22440
aatcaactct aatcacttta acttttacag ttttccctac cagtttatcc ctatattcaa 22500
catatctatc catatgcatc ttaacactct ctgccaagat agcttcagag tgaggatagt 22560
caaaaagata aatatataga gcataatcat tctcgtatac tctgcccttt attacatcgc 22620
ccgcattggg caacgaataa caaaatgcaa gcatcttgtt aacgggctcg taaattggga 22680
taaaaattat gtttttatat ctattttatt caagagaata ttcaggaatt tctttttccg 22740
gttgtatctc atcgcagtat atatcatttg tacattgttt catatttttt aatagtttac 22800
accttttagt aggactagta tcgtacaatt catagctgta ttttgaattc caatcacgca 22860
taaaaatatc ttctaattgt tgacgaagac ctaatccatc atccggtgta atattaatag 22920
atgctccaca tgtatccgta aagtaatttc ctgtccaatt tgaggtacct atataggccg 22980
ttttatcggt taccatatat ttggcatggt ttaccctaga atacggaatg ggaggatcag 23040
catctggtac aataaatagc tttacttcta tatttatgtt tttagatttt agcatagcga 23100
tagatcttaa aaagtttctc atgataaacg aagatcgttg ccagcaacta atcaatagct 23160
taacggatac ttgtctgtct atagcggatc ttcttaattc atcttctata taaggccaaa 23220
acaaaatttt acccgccttc gaataaataa tagggataaa gttcataaca gatacataaa 23280
cgaatttact cgcatttcta atacatgaca ataaagcggt taaatcattg gttctttcca 23340
tagtacatag ttgttgcggt gcagaagcaa taaatacaga gtgtggaaca ccacttacgt 23400
taatactaag aggatgatct gtattataat acgacggata aaagtttttc caattatatg 23460
gtagattgtt aactccaaga taccagtata cctcaaaaat ttgagtgaga tccgctgcca 23520
agttcctatt attgaagatc gcaataccca attctttgac ctgagttagt gatctccaat 23580
ccatgttagc gcttcctaaa taaatatgtg tattatcaga tatccaaaat tttgtatgaa 23640
gaactcctcc taggatattt gtaatatcta tgtatcgtac ttcaactccg gccatttgta 23700
gtctttcaac atcctttaat ggtttgttag atttattgac ggctactcta actcgtactc 23760
ctcttttggg taattgtaca atctcgttta atattatcgt gccgaaattc gtacccactt 23820
catccgataa actccaataa aaagatgata tatctagtgt ttttgtggta ttggatagaa 23880
tttccctcca catgttaaat gtagacaaat atactttatc aaattgcata cctataggaa 23940
tagtctctgt aatcactgcg attgtattat ccggattcat tttatttgtt aaaagaataa 24000
tcctatatca cttcactcta ttaaaaatcc aagtttctat ttctttcatg actgattttt 24060
taacttcatc cgtttcctta tgaagatgat gtttggcacc ttcataaatt tttatttctc 24120
tattacaatt tgcatgttgc atgaaataat atgcacctaa aacatcgcta atctcattgt 24180
ttgttccctg gagtatgaga gtcggggtgt taatcttgga aattattttt ctaaccttgt 24240
tggtagcctt caagacctga ctagcaaatc cagccttaat tttttcatga ttgattaatg 24300
ggtcgtattg gtatttataa actttatcca tatctctaga tactgattct ggacatagct 24360
ttccgactgg cgcatttggt gtgatggttc ccataagttt ggcagctagc agattcagtc 24420
ttgaaacagc atctgcatta actagaggag acattagaat cattgctgta aacaagtttg 24480
gattatcgta agaggctagt atagaaattg ttgctcccat ggaatgaccc aataagtaga 24540
tttaatagtt accacgtgct gtaccaaagt catcaatcat cattttttca ccattacttc 24600
ttccatgtcc aatatgatca tgtgagaata ctaaaattcc taacgatgat atgttttcag 24660
ctagttcgtc ataacgtcca gaatgtttac cagctccatg acttatgaat actaatgcct 24720
taggatatgt aatcattgtc cagattgaac atacagtttg cactcatgat tcacgttata 24780
taactatcaa tattaacagt tcgtttgatg atcatattat ttttatgttt tattgataat 24840
tgtaaaaaca tacaattaaa tcaatataga ggaaggagac ggctactgtc ttttgtgaga 24900
tagtcatggc gactaaatta gattatgagg atgctgtttt ttactttgtg gatgatgata 24960
aaatatgtag tcgcgactcc atcatcgatc taatagatga atatattacg tggagaaatc 25020
atgttatagt gtttaacaaa gatattacca gttgtggaag actgtacaag gaattgatga 25080
agttcgatga tgtcgctata cggtactatg gtattgataa aattaatgag attgtcgaag 25140
ctatgagcga aggagaccac tacatcaatt ttacaaaagt ccatgatcag gaaagtttat 25200
tcgctaccat aggaatatgt gctaaaatca ctgaacattg gggatacaaa aagatttcag 25260
aatctagatt ccaatcattg ggaaacatta cagatctgat gaccgacgat aatataaaca 25320
tcttgatact ttttctagaa aaaaaattga attgatgata taggggtctt cataacgcat 25380
aattattacg ttagcattct atatccgtgt taaaaaaaat tatcctatca tgtatttgag 25440
agttttatat gtagcaaaca tgatagctgt gatgccaata agctttagat attcacgcgt 25500
gctagtgtta gggatggtat tatctggtgg tgaaatgtcc gttatataat ctacaaaaca 25560
atcatcgcat atagtatgcg atagtagagt aaacattttt atagttttta ctggattcat 25620
acatcgtcta cccaattcgg ttatgaatga aattgtcgcc aatcttacac ccaacccctt 25680
gttatccatt agtatagtat taacttcgtt atttatgtca taaactgtaa atgattttgt 25740
agatgccata tcatacatga tattcatgtc cctattataa tcattactaa ctttatcaca 25800
atatatgttg ataatatcta tatatgatct agtctttgtg ggcaactgtc tatacaagtc 25860
gtctaaacgt tgtttactca tatagtatcg aacagccatc attacatggt cccgttccgt 25920
tgatagataa tcgagtatgt tagtggactt gtcaaatcta tataccatat tttctggaag 25980
tggatataca tagtcgtgat caacattatt gctagcctca tcttctatat cctgtactat 26040
accatctaca taatctacga tattattaca cataaacatc gacaacatac tattgtttat 26100
tatctaagtc ctgttgatcc aaacccttga tctcctctat ttgtactatc tagagattgt 26160
acttcttcca gttctggata atatatacgt tgatagatta gctgagctat tctatctcca 26220
gtatttacat taaacgtaca ttttccatta ttaataagaa tgactcctat gtttccccta 26280
taatcttcgt ctattacacc acctcctata tcaatgcctt ttagtgacag accagaccta 26340
ggagctattc taccatagca aatcttaggc atggacatac taatatctgt cttaattaac 26400
tgtctttctc ctggagggat agtataatcg taagcgctat acaaatcata tccggcagca 26460
cccggcgatt gcctagtagg agatttagct ctgttagttt ccttaacaaa tctaactggt 26520
gagttaatat tcatgttgaa cataaaacta atattttatt tcaaaattat ttaccatccc 26580
atatattcca tgaataagtg tgatgattgt acacttctat agtatctata tacgattcac 26640
gataaaatcc tcctatcaat agcagtttat tatccactat gatcaattct ggattatccc 26700
tcggataaat aggatcatct atcagagtcc atgtattgct ggattcacaa taaaattccg 26760
catttctacc aaccaagaat aaccttctac cgaacactaa cgcgcatgat ttataatgag 26820
gataataagt ggatggtcca aactgccact gatcatgatt gggtagcaaa tattctgtag 26880
ttgtatcagt ttcagaatgt cctcccatta cgtatataac attgtttatg gatgccactg 26940
ctggattaca tctaggtttc agaagactcg gcatattaac ccaagcagca tccccgtgga 27000
accaacgctc aacagatgtg ggatttggta gacctcctac tacgtataat ttattgttag 27060
cgggtatccc gctagcatac agtctggggc tattcatcgg aggaattgga atccaattgt 27120
ttgatatata atttacagct atagcattgt tatgtatttc attgttcatc catccaccga 27180
tgagatatac tacttctcca acatgagtac ttgtacacat atggaatata tctataattt 27240
gatccatgtt cataggatac tctatgaatg gatacttgta tgatttgcgt ggttgtttat 27300
cacaatgaaa tattttggta cagtctagta tccattttac attatttata cctctgggag 27360
aaagataatt tgacctgatt acatttttga taaggagtag cagatttcct aatttatttc 27420
ttcgctttat ataccactta atgacaaaat cctcatctgg aacatttagt tcatcgcttt 27480
ctagaataag tttcatagat agataatcaa aattgtctat gatgtcatct tccagttcca 27540
aaaagtgttt ggcaataaag tttttagtat gacataagag attggatagt ccgtattcta 27600
tacccatcat gtaacactcg acacaatatt cctttctaaa atctcgtagg ataaagttta 27660
tacaagtgta gatgataaat tctacagagg ttaatataga agcacgtaat aaattgacga 27720
cgttatgact atctatatat acctttccag tatatgagta aataactata gaagttagac 27780
tgtgaatgtc aaggtctaga caaaccctcg taactggatc tttatttttc gtgtattttt 27840
gacgtaaatg tgtgcgaaag taaggagata actttttcaa tatcgtagaa ttgactatta 27900
tattgcctcc tatggcatca ataattgttt tgaatttctt agtcatagac aatgctaata 27960
tattcttaca gtacacagta ttgacaaata tcggcattta tgtttcttta aaagtcaaca 28020
tctaaagaaa aatgattatc ttcttgagac ataactccca ttttttggta ttcacccaca 28080
cgtttttcga aaaaattagt tttaccttct aatgatatat tttccatgaa atcaaacgga 28140
ttggtaacat tataaatttt tttaaatccc aattcagaaa tcaatctatc cgcgacgaat 28200
tctatatatg ttttcatcat ttcacaattc attcctataa gtttaactgg aagagccgca 28260
gtaagaaatt cttgttcaat ggataccgca tctgttataa tagatctaac ggtttcttca 28320
ctcggtggat gcaataaatg tttaaacatc aaacatgcga agtcgcagtg tagaccctcg 28380
tctctactaa tcaattcgtt ggaaaacgtg agtccgggca ttaggccacg ctttttaagc 28440
caaaatatgg aagcgaatga tccggaaaag aagattcctt ctactgcagc aaaggcaata 28500
agtctctctc cataaccggc gctgtcatgt atccactttt gagcccaatc ggccttcttt 28560
tttacacaag gcatcgtttc tatggcatta aagagatagt ttttttcatt actatcttta 28620
acataagtat cgatcaaaag actatacatt tccgaatgaa tgttttcaat ggccatctga 28680
aatccgtaga aacatctagc ctcggtaatc tgtacttctg tacaaaatcg ttccgccaaa 28740
ttttcattca ctattccgtc actggctgca aaaaacgcca atacatgttt tataaaatat 28800
ttttcgtctg gtgttagttt attccaatca ttgatatctt tagatatatc tacttcttcc 28860
actgtccaaa atgatgcctc tgccttttta tacatgttcc agatgtcatg atattggatt 28920
gggaaaataa caaatctatt tggatttggt gcaaggatgg gttccataac taaattaaca 28980
ataacaataa attttttttc agttatctat atgcctgtac ttggatcttt tgtacatcga 29040
tatcgccgca atcactacaa taattacaag tattattgat agcattgtta ttagtactat 29100
cataattaaa ttatcgttat tatcattttg taattgtgac atcatactag ataaatcgtt 29160
tgcgagattg ttgtgggaag cgggcatgga ggatgaatta tcgttattat tatttaaagc 29220
ctcccattcg gattcacaaa tatggcgcgc gttcaacatt ttatggaaac agataacaag 29280
aaaactcgtc atcgttcaaa tttttaacga tagtaaaccg attaaacgtc gagctaattt 29340
ctaacgctag cgactctgtt ggatatgggt ttccagatat atatcttttc agttccccta 29400
cgtatctata atcatctgta ggaaatggaa gatatttcca tttatctact gttcctaata 29460
tcatatgtgg tggtgtagta gaaccattaa gcgcgaaaga tgttatttcg catcgtattt 29520
taacttcgca ataatttctg gttagataac gcactctacc agtcaagtca atgatattag 29580
cctttacaga tatattcata gtagtcgtaa cgatgactcc atcttttaga tgcgatactc 29640
ctttgtatgt accagaatct tcgtacctca aactcgatat atttaaacaa gttaatgaga 29700
tattaacgcg ttttatgaat gatgatatat aaccagaagt tttatcctcg gtggctagcg 29760
ctataacctt atcattataa taccaactag tgtgattaat atgtgacacg ttagtgtggg 29820
tacaaatatg tacattatcg tctacgtcgt attcgataca tccgcataca gccaacaaat 29880
ataaaatgac aaatactcta acgccgttcg tacccatctt gatgcggttt aataaatgtt 29940
ttgatttcaa tttattgtaa aaaaagattc ggttttatac tgttcgatat tctcattgct 30000
tatattttca tctatcatct ccacacagtc aaatccgtgg ttagcatgca cctcatcaac 30060
cggtaaaaga ctatcggact cttctatcat tataactcta gaatatttaa tttggtcatt 30120
attaatcaag tcaattatct tatttttaac aaacgtgagt attttactca ttttttataa 30180
aaacttttag aaatatacag actctatcgt gtgtctatat cttcttttta tatccaatgt 30240
atttatgtct gatttttctt catttatcat atataatggt ccaaattcta cacgtgcttc 30300
ggattcatcc agatcattaa ggttcttata attgtaacat ccttctcttc cctcttctac 30360
atcttccttc ttattcttat tcttagcgtc acagaatcta ccacagcagg atcccatgac 30420
gagcgtcata ttaaactaat ccattttcaa ttataatata cgattagtaa tgaccattaa 30480
aataaaaata ttcttcataa ccggcaagaa agtgaaaagt tcacattgaa actatgtcag 30540
tagtatacat catgaaatga tgatatatat atactctatt ttggtggagg attatatgat 30600
ataattcgtg gataatcatt cttaagacac atttcttcat tcgtaaatct tttcacgtta 30660
aatgagtgtc catattttgc aatttcttca tatgatggcg gtgtacgtgg acgaggctgc 30720
tcctgttctt gttgtagtcg ccgactgtcg tgtctgcgtt tagatccctc cattatcgcg 30780
attgcgtaga tggagtacta ttttatacct tgtaattaaa tttttttatt aattaaacgt 30840
ataaaaacgt tccgtatctg tatttaagag ccagatttcg tctaatagaa caaatagcta 30900
cagtaaaaat aactagaata attgctacac ccactagaaa ccacggatcg taatacggca 30960
atcggttttc gataataggt ggaacgtata ttttatttaa ggacttaaca attgtctgta 31020
aaccacaatt tgcttccgcg gatcctgtat taactatctg taaaagcata tgttgaccgg 31080
gcggagccga acattctccg atatccaatt tctgtatatc tataatatta ttaacctccg 31140
catacgcatt acagttcttt tctagcttgg ataccgcact aggtacatcg tctagatcta 31200
ttcctatttc ctcagcgata gctcttctat ccttttccgg aagcaatgaa atcacttcaa 31260
taaatgattc aaccatgagt gtgaaactaa gtcgagaatt actcatgcat ttgttagtta 31320
ttcggagcgc gcaattttta aactgtccta taacctctcc tatatgaata gcacaagtga 31380
cattagtagg gatagaatgt tgagctaatt tttgtaaata actatctata aaaagattat 31440
acaaagtttt aaactcttta gtttccgcca tttatccagt ctgagaaaat gtctctcata 31500
ataaattttt ccaagaaact aattgggtga agaatggaaa cctttaatct atatttatca 31560
cagtctgttt tggtacacat gatgaattct tccaatgccg tactaaattc gatatctttt 31620
tcgatttctg gatatgtttt taataaagta tgaacaaaga aatggaaatc gtaataccag 31680
ttatgtttaa ctttgaaatt gttttttatt ttcttgttaa tgattccagc cacttgggaa 31740
aagtcaaagt cgtttaatgc cgatttaata cgttcattaa aaacaaactt tttatccttt 31800
agatgaatta ttattggttc attggaatca aaaagtaaga tattatcggg tttaagatct 31860
gcgtgtaaaa agttgtcgca gcatggtagt tcgtaaattt taatgtataa cagagccatc 31920
tgtaaaaaga taaactttat gtattgtacc aaagatttaa atcctaattt gatagctagc 31980
tcggtatcta ctttatctgc cgaatacagt gctaggggaa aaattataat atttcctctt 32040
tcgtattcgt agttagttct cttttcatgt tcgaaaaagt gaaacatgcg gttaaaatag 32100
tttataacat taatattact gttaataact gccggataaa agtgggatag taatttcacg 32160
aatttgatac tgtcctttct ctcgttaaac gcctttaaaa aaactttaga agaatatctc 32220
aatgatagtt cctgaccatc catagtttgt atcaataata gcaacatatg aagaacacgt 32280
ttatacagag tatgtaaaaa tgttaattta tagtttaatc ccatggccca cgcacacacg 32340
attaattttt tttcatctcc ctttagattg ttgtatagaa atttgggtac tgtgaactcc 32400
gccgtagttt ccatgggact atataatttt gtggcctcga atacaaattt tactacatag 32460
ttatctatct taaagactat accatatcct cctgtagata tgtgataaaa atcgtcgttt 32520
ataggataaa atcgtttatc cttttgttgg aaaaaggatg aattaatgta atcattctct 32580
tctatcttta gtagtgtttc cttattaaaa ttcttaaaat aatttaacaa tctaactgat 32640
ggagcccaat tttggtgtaa atctaattgg gacattatat tgttaaaata caaacagtct 32700
cctaatataa cagtatctga taatctatgg ggagacatcc attgatattc aggggatgaa 32760
tcattggcaa cacccattta ttgtacaaaa agccccaatt tacaaacgaa agtccaggtt 32820
tgatagagac aaactattaa ctattttgtc tctgttttta atttctttgg taatgaaatt 32880
attcacaata tcagtatctt ctttatctac cagagatttt actaacttga taaccttggc 32940
tgtctcattc aatagggtag taatatttgt atgtgtgata ttgatatctt ttagaagtga 33000
ttctttgatg gtgccagcat acgaattaca ataatgcaga aactcggtta acatgcagga 33060
attatagtaa gccaattcca attgttgcct gtgttgtatt agagtgtcaa tatgagcaat 33120
ggtgtccttg cgtttctctg atagaatgcg agcagcgatt ttggcgttat catttgacga 33180
tatttctgga atgacgaatc ctgtttctac taactttttg gtaggacaaa gtgaaacaat 33240
caagaagata gcttctcctc ctatttgtgg aagaaattga actcctctag atgatctcct 33300
tgacagatat tggaccgaat tacagaagta cctggaatgt aaagccctga aaccccctca 33360
ttttttaagc agattgttgc cgtaaatcct gcactatgcc caagatagag agctcctttg 33420
gtgaatccat ctctatgttt cagtttaacc aagaaacagt cagctggtct aaaatttcca 33480
tctctatcta atacagcatc taacttgatg tcaggaacta tgaccggtta tgttatatgt 33540
aacattgagt aaatccttaa gttcataatc atcactgtca tcagttatgt acgatccaaa 33600
caatgtttct actggcatag tggatacgaa gatgctatcc atcagaatgt ttccctgatt 33660
agtattttct atatagctat tcttctttaa acgattttcc aaatcagtaa ctatgttcat 33720
ttttttagga gtaggacgcc tagccagtat ggaagaggat tttctagatc ctctcttcaa 33780
catctttgat ctcaatggaa tgcaaaaccc catagtgtaa caaccaacga taaaaataat 33840
attgtttttc actttttata attttaccat ctgactcatg gattcattaa tatctttata 33900
agagctacta acgtataatt ctttataact gaactgagat atatacaccg gatctatggt 33960
ttccataatt gagtaaatga atgctcggca ataactaatg gcaaatgtat aaaacaacga 34020
aattatacta gagttgttaa agttaatatt ttctatgagc tgttccaata aattatttgt 34080
tgtaactgcg ttcaagtcat aaatcatctt gatactatcc agtaaaccgt ttttaagttc 34140
tggaatatta ttatcccatt gtaaagcccc taattcgact atcgaatatc ctgctctgat 34200
agcagtttca atatcgacgg acgtcaatac tgtaataaag gtggtagtat tgtcatcatc 34260
gtgataaact actggaatat ggtcgttagt aggtacggta actttacaca acgcgatata 34320
taactttcct tttgtaccat ttttaacgta gttgggacgt cctgcagggt attgttttga 34380
agaaatgata tcgagaacag atttgatacg atatttgttg gattcctgat tatttactat 34440
aatataatct agacagatag atgattcgat aaatagagaa ggtatatcgt tggtaggata 34500
atacatcccc attccagtat tctcggatac tctattaatg acactagtta agaacatgtc 34560
ttctattcta gaaaacgaaa acatcctaca tggactcatt aaaacttcta acgctcctga 34620
ttgtgtctcg aatgcctcgt acaaggattt caaggatgcc atagattctt tgaccaacga 34680
tttagaattg cgtttagcat ctgatttttt tattaaatcg aatggtcggc tctctggttt 34740
gctaccccaa tgataacaat agtcttgtaa agataaaccg caagaaaatt tatacgcatc 34800
catccaaata accctagcac catcggatga tattaatgta ttattataga ttttccatcc 34860
acagttattg ggccagtata ctgttagcaa cggtatatcg aatagattac tcatgtaacc 34920
tactagaatg atagttcgtg tactagtcat aatatcttta atccaatcta agaaatttaa 34980
aattagattt tttacactgt taaagttaac aaaggtatta cccggatacg tggatatcat 35040
atatggtatt ggtccattat cagtaatagc tccataaact gatacggcga tggtttttat 35100
atgtgtttga tctaacgagg aagaaattcg cgcccacaat tcatctctag atatgtattt 35160
aatatcaaac ggtaacacat caatttcggg acgcgtatat gtttctaaat ttttaatcca 35220
aatataatga tgacctatat gccctattat catactgtca actatagtac acctagagaa 35280
cttacgatac atctgtttcc tataatcgtt aaattttaca aatctataac atgctaaacc 35340
ttttgacgac aaccattcat taatttctga tatggaatct gtattctcaa taccgtatcg 35400
ttctaaagcc agtgctatat ctccctgttc gtgagaacgc tttcgtataa tatcgatcaa 35460
cggataatct gaagtttttg gagaataata tgactcatga tctatttcgt ccataaacaa 35520
tctagacata ggaattggag gcgatgatct taattttgtg caatgagtcg tcaatcctat 35580
aacttctaat attgtaatat tcatcatcga cataacacta tctatgttat catcgtatat 35640
tagtatacca tgaccttctt catttcgtgc caaaatgata tacagtctta aatagttacg 35700
caatatctca atagtttcat aattgttagc tgttttcatc aaggtttgta tcctgtttaa 35760
catgatggcg ttctatacgt ttctattttt taaattttta acgatttact gtggctagat 35820
acccaatctc tctcaaatat ttttttagcc tcgcttacaa gctgtttatc tatactatta 35880
aaactgacga atccgtgatt ttggtaatgg gttccgtcga aatttgccga agtgatatga 35940
acatattcgt cgtcgactat caacaatttt gtattattct gaatagtgaa aaccttcaca 36000
gatagatcat tttgaacaca caacgcgtct agacttctgg cggttgccat agaatatacg 36060
tcgttcttat cccaattacc aactagaagt ctgatcttaa ctcctctatt aatggctgct 36120
tctataatgg agttgtaaat gtcgggccaa tagtagctat taccgtcgac acgtgtagtg 36180
ggaactatgg ccaaatgttc aatatctata ctagtcttag ccgacttgag tttatcaata 36240
actacatcag tgtctagatc tctagaatat cccaataggt gttccggaga atcagtaaag 36300
aacactccac ctataggatt cttaatatga tacgcagtgc taactggcag acaacaagcc 36360
gcagagcata aattcaacca tgaatttttt gcgctattaa aggctttaaa agtatcaaat 36420
cttctacgaa gatctgtggc cagcggggga taatcagaat atacacctaa cgttttaatc 36480
gtatgtatag atcctccagt aaatgacgcg tttcctacat aacatctttc attatctgac 36540
acccaaaaac aaccgagtag tagtcccaca ttattttttt tatctatatt aacggttata 36600
aaatttatat ccgggcagtg actttgtagc tctcccagat ttcttttccc tcgttcatct 36660
agcaaaacta ttattttaat ccctttttca gatgcctctt ttagtttatc aaaaataagc 36720
gctcccctag tcgtactcag aggattacaa caaaaagatg ctatgtatat atatttctta 36780
gctagagtga taatttcgtt aaaacattca aatgttgtta aatgatcgga tctaaaatcc 36840
atattttctg gtagtgtttc taccagccta cattttgctc ccgcaggtac cggtgcaaat 36900
ggccacattt agttaacata aaaacttata catcctgttc tatcaacgat tctagaatat 36960
catcggctat atcgctaaaa ttttcatcaa agtcgacatc acaacctaac tcagtcaata 37020
tattaagaag ttccatgatg tcatcttcgt ctatttctat atccgtatcc attgtagatt 37080
gttgaccgat tatcgagttt aaatcattac taatactcaa tccttcagaa tacaatctgt 37140
gtttcattgt aaatttatag gcggtgtatt taagttggta gattttcaat tatgtatcaa 37200
tatagcaaca gtagttcttg ctcctccttg attctagcat cctcttcatt attttcttct 37260
acgtacataa acatgtccaa tacgttagac aacacaccga cgatggcggc cgccacagac 37320
acgaatatga ctaaaccgat gaccatttaa aaacccctct ctagctttca cttaaactgt 37380
atcgattatt cttttagaac atgtataata taaaaacatt attctatttc gaatttaggc 37440
ttccaaaaat ttttcatccg taaaccgata ataatatata tagacttgtt aatagtcgga 37500
ataaatagat taatgcttaa actatcatca tctccacgat tagagataca atatttacat 37560
tttttttgct gtttcgaaac tttatcaata cacgttaata caaacccagg aaggagatat 37620
tgaaactgag gctgttgaaa atgaaacggt gaatacaata attcagataa tgtaaaatca 37680
tgattccgta ttctgatgat attagaactg ctaatggatg tcgatggtat gtatctagga 37740
gtatctattt taacaaagca tcgatttgct aatatacaat tatcattttg attaattgtt 37800
attttattca tattcttaaa aggtttcata tttatcaatt cttctacatt aaaaatttcc 37860
atttttaatt tatgtagccc cgcaatactc ctcattacgt ttcatttttt gtctataata 37920
tccattttgt tcatctcggt acatagatta tccaattgag aagcgcattt agtagttttg 37980
tacattttaa gtttattgac gaatcgtcga aaactagtta tagttaacat tttattattt 38040
gataccctga tattaatacc cctgccgtta ctattattta taactgatgt aatccacgta 38100
acattggaat taactatcga tagtaatgca tcgacgcttc caaaattgtc tattataaac 38160
tcaccgataa tttttttatt acatgttttc atattcatta ggattattaa atctttaatc 38220
ttactacgat tgtatgcgtt gatattgcaa gacgtcattc taaaagacgg aggatctcca 38280
tcaaatgcca gacaatcacg tacaaagtac atggaaatag gttttgttct attgcgcatc 38340
atagatttat atagaacacc cgtagaaata ctaatttgtt ttactctata aaatactaat 38400
gcatctattt catcgttttg tataacgtct ttccaagtgt caaattccaa atttttttca 38460
ttgatagtac caaattcttc tatctcttta actacttgca tagataggta attacagtga 38520
tgcctacatg ccgttttttg aaactgaata gatgcgtcta gaagcgatgc tacgctagtc 38580
acaatcacca ctttcatatt tagaatatat atatgtaaaa atatagtaga atttcatttt 38640
gttttttttc tatgctataa atgaattctc attttgcatc tgctcatact ccgttttata 38700
tcaataccaa agaaggaaga tatctggttc taaaagccgt taaagtatgc gatgttagaa 38760
ctgtagaatg cgaaggaagt aaagcttcct gcgtactcaa agtagataaa ccctcatcac 38820
ccgcgtgtga gagaagacct tcgtcccctt ccagatgcga gagaatgaat aacccaggaa 38880
aacaagttcc gtttatgagg acggacatgc tacaaaatat gttcgcggct aatcgcgata 38940
atgtagcttc tagacttttg tcctaaaata caattatatc cttttcgata ttaataaatc 39000
cgtgtcgtcc aggtttttta tctctttcag tatgtgaata gataggtatt ttatctctat 39060
tcatcatcga atttaagaga tccgataaac attgtttgta ttctccagat gtcagcatct 39120
gatacaacaa tatatgtgca cataaacctc tggcacttat ttcatgtacc ttccccttat 39180
cactaaggag aatagtattt gagaaatatg tatacatgat attatcatga attagatata 39240
cagaatttgt aacactctcg aaatcacacg atgtgtcggc gttaagatct aatatatcac 39300
tcgataacac attttcatct agatacacta gacatttttt aaagctaaaa tagtctttag 39360
tagtaacagt aactatgcga ttattttcat cgatgataca tttcatcggc atattattac 39420
gcttaccatc aaagactata ccatgtgtat atctaacgta ttctagcatg gttgccatac 39480
gcgcattaaa cttttcagga tctttggata gatcttccaa tctatctatt tgagaaaaca 39540
tttttatcat gttcaatagt tgaaacgtcg gatccactat atagatatta tctataaaga 39600
ttttaggaac tacgttcatg gtatcctggc gaatattaaa actatcaatg atatgattat 39660
cgttttcatc ttttatcacc atatagtttc taagatatgg gattttactt aatataatat 39720
tatttcccgt aataaatttt attagaaatg ccaaatctat aagaaaagtc ctcgaattag 39780
tttgaagaat atctatatcg ccgtaccgta tatttggatt aattagatat agagaatatg 39840
atccgtaaca tatacaactt ttattatggc gtctaagata ttcttccatc aacttattaa 39900
catttttgac tagggaagat acattatgac gtcccattac ttttgccttg tctattactg 39960
cgacgttcat agaatttagc atatctcttg ccaattcttc cattgatgtt acattataag 40020
aaattttaga tgaaattaca tttggagctt taatagtaag aactcctaat atgtccgtgt 40080
atgtggtcac taatacagat tgtagttcta taatcgtaaa taatttacct atattatatg 40140
tttgagtctg tttagaaaag tagctaagta tacgatcttt tatttctgat gcagatgtat 40200
caacatcgga aaaaaatctt tttttattct tttttactaa agatacaaat atgtctttgt 40260
taaaaacagt tattttctga atatttctag cttgtaattt taacatatga tattcgttca 40320
cactaggtac tctgcctaaa taggtttcta taatctttaa tgtaatatta ggaaaagtat 40380
tctgatcagg attcctattc attttgagga tttaaaactc tgattattgt ctaatatggt 40440
ctcaacacaa actttttcac agagcgatag agtttttgat aactcgtttt tcttaagaaa 40500
tataaaacta ctgtctccag agctcgctct atcttttatt ttatttaatt cgatacaaac 40560
tcctgatact ggttcagaaa gtaattcatt aattttcagt cctttataga agatatttaa 40620
tatagataat acaaaatctt cagtttttga tatcgatctg attgatccta gaactagata 40680
tattaataac gtgctcatta ggcagtttat ggcagcttga taattagata tagtatattc 40740
cagttcatat ttattagata ccgcattgcc cagattttga tattctatga attcctctga 40800
aaataaatcc aaaataacta gacattctat tttttgtgga ttagtgtact ctcttccctc 40860
tatcatgttc actactggtg tccacgatga taaatatcta gagggaatat aatatagtcc 40920
ataggatgcc aatctagcaa tgtcgaataa ctgtaatttt attcttcgct cttcattatg 40980
aattgattct tgaggtataa acctaacaca aattatatta ttagactttt cgtatgtaat 41040
gtctttcatg ttataagttt ttaatcctgg aatagaatct attttaatga ggcttttaaa 41100
cgcagagttc tccaacgagt caaagcataa tactctgttg gttttcttat atacgatgtt 41160
acgattttct tctttgaatg gaataggttt ttgaattagt ttataattac aacataatag 41220
ataaggaagt gtgcaaatag tacgcggaaa aaacataata gctcccctgt tttcatccat 41280
ggttttaagt aaatgatcac tggcttcttt agtcaatgga tattcgaaca ttaaccgttt 41340
catcatcatt ggacagaatc catatttctt aatgtaaaga gtgatcaaat cattgtgttt 41400
attgtaccat cttgttgtaa atgtgtattc ggttatcgga tctgctcctt tttctattaa 41460
agtatcgatg tcgatctcgt ctaagaattc aactatatcg acatatttca tttgtataca 41520
cataaccatt actaacgtag aatgtatagg aagagatgta acgggaacag ggtttgttga 41580
ttcgcaaact attctaatac ataattcttc tgttaatacg tcttgcacgt aatctattat 41640
agatgccaag atatctatat aattattttg taagatgatg ttaactatgt gatctatata 41700
agtagtgtaa taattcatgt atttcgatat atgttccaac tctgtctttg tgatgtctag 41760
tttcgtaata tctatagcat cctcaaaaaa tatattcgca tatattccca agtcttcagt 41820
tctatcttct aaaaaatctt caacgtatgg aatataataa tctattttac ctcttctgat 41880
atcattaatg atatagtttt tgacactatc ttctgtcaat tgattcttat tcactatatc 41940
taagaaacgg atagcgtccc taggacgaac tactgccatt aatatctcta ttatagcttc 42000
tggacataat tcatctatta taccagaatt aatgggaact attccgtatc tatctaacat 42060
agttttaaga aagtcagaat ctaagacctg atgttcatat attggttcat acatgaaatg 42120
atctctattg atgatagtga ctatttcatt ctctgaaaat tggtaactca ttctatatat 42180
gctttccttg ttgatgaagg atagaatata ctcaatagaa tttgtaccaa caaactgttc 42240
tcttatgaat cgtatatcat catctgaaat aatcatgtaa ggcatacatt taacaattag 42300
agacttgtct cctgttatca atatactatt cttgtgataa tttatgtgtg aggcaaattt 42360
gtccacgttc tttaattttg ttatagtaga tatcaaatcc aatggagcta cagttcttgg 42420
cttaaacaga tatagttttt ctggaacgaa ttctacaaca ttattataaa ggactttggg 42480
tagataagtg ggatgaaatc ctattttaat taatgcgata gccttgtcct cgtgcagata 42540
tccaaacgct tttgtgatag tatggcattc attgtctaga aacgctctac gaatatctgt 42600
gacagatatc atctttagag aatatactag tcgcgttaat agtactacaa tttgtatttt 42660
ttaatctatc tcaataaaaa aattaatatg tatgattcaa tgtataacta aactactaac 42720
tgttattgat aactagaatc agaatctaat gatgacgtaa ccaagaagtt tatctactgc 42780
caatttagct gcattatttt tagcatctcg tttagatttt ccatctgcct tatcgaatac 42840
tcttccgtcg atatctacac aggcataaaa tgtaggagag ttactaggcc ccactgattc 42900
aatacgaaaa gaccaatctc tcttagttat ttggcagtac tcattaataa tggtgacagg 42960
gttagcatct ttccaatcaa taattttttt agccggaata acatcatcaa aagacttatg 43020
atcctctctc attgattttt cgcgggatac atcatctatt atggcgtcag ccataacatc 43080
agcatccggc ttatccgcct ccgttgtcat aaaccaacga ggaggaatat cgtcggagct 43140
gtacaccata gcactacgtt gaagatcgta cagagcttta ttaacttctc gcttctccat 43200
attaagttgt ctagttagtt gtgcagcagt agctccttcg attccaatgt ttttaatagc 43260
cgcacacaca atctctgcgt cagaacgctc gtcaatatag atcttagaca tttttagaga 43320
gaactaacac aaccagcaat aaaactaatt tattttatca tttttttatt catcatcctc 43380
tggtggttcg tcgtttctat cgaatgtgga tctgattaac ccgtcatcta taggtgatgc 43440
tggttctgga gattctggag gagatggatt attatctgga agaatctctg ttatttcctt 43500
gttttcatgt atcgattgcg ttgtaacatt aagattgcga aatgctctaa atttgggagg 43560
cttaaagtgt tgtttgcaat ctctacacgc atgtctaact agtggaggtt cgtcagcggc 43620
tctagtttga atcatcatcg gcgtagtatt cctactttta cagttaggac acggtgtatt 43680
gtatttctcg tcgagaacgt taaaataatc gttgtaactc acatccttta ttttatctat 43740
attgtattct actcctttct taatgcattt tataccgaat aagagatagc gaaggaattc 43800
tttttcggtg ccgctagtac ccttaatcat atcacatagt gttttatatt ccaaatttgt 43860
ggcaatagac ggtttatttc tatacgatag tttgtttctg gaatcctttg agtattctat 43920
accaatatta ttctttgatt cgaatttagt ttcttcgata ttagattttg tattacctat 43980
attcttgatg tagtactttg atgatttttc catggcccat tctattaagt cttccaagtt 44040
ggcatcatcc acatattgtg atagtaattc tcggatatca gtagcggcta ccgccattga 44100
tgtttgttca ttggatgagt aactactaat gtatacattt tccatttata acacttatgt 44160
attaactttg ttcatttata ttttttcatt attatgttga tattaacaaa agtgaatata 44220
tatgttaata attgtattgt ggttatacgg ctacaatttc ataatgagtg gaagtcagtg 44280
tccgatgatc aatgacgata gctttactct gaaaagaaag tatcaaatcg atagtgcgga 44340
gtcaacaata aaaatggata agaagaggat aaagtttcag aatagagcca aaatggtaaa 44400
agaaataaat cagacaataa gagcagcaca aactcattac gagacattga aactaggata 44460
cataaaattt aagagaatga ttaggactac tactctagaa gatatagcac catctattcc 44520
aaataatcag aaaacttata aactattctc ggacatttca gccatcggca aagcatcaca 44580
gaatccgagt aagatggtat atgctctgct gctttacatg tttcccaatt tgtttggaga 44640
tgatcataga ttcattcgtt atagaatgca tccaatgagt aaaatcaaac acaagatctt 44700
ctctcctttc aaacttaatc ttattagaat attagtggaa gaaagattct ataataatga 44760
atgcagatct aataaatgga gaataattgg aacacaagtt gataaaatgt tgatagctga 44820
atctgataaa tatacaatag atgcaaggta taacctaaaa cccatgtata gaatcaaggg 44880
aaaatctgaa gaagataccc tctttatcaa acagatggta gaacaatgtg tgacatccca 44940
ggaattggtg gaaaaagtgt tgaagatact gtttagagat ttgttcaaga gtggagaata 45000
caaagcgtac agatacgatg atgatgtaga aaatggattt attggattgg atacactaaa 45060
attaaacatt gttcatgata tagttgaacc atgtatgcct gttcgtaggc cagtggctaa 45120
gatactgtgt aaagaaatgg taaataaata ctttgagaat ccgctacata ttattggtaa 45180
aaatcttcaa gagtgcattg actttgttag tgaataggca tttcatcttt ctccaatact 45240
aattcaaatt gttaaattaa taatggatag tataaatagt tattagtgat aaaatagtaa 45300
aaataattat tagaataaga gtgtagtatc atagataact ctcttctata aaaatggatt 45360
ttattcgtag aaagtatctt atatacacag tagaaaataa tatagatttt ttaaaggatg 45420
atacattaag taaagtaaac aattttaccc tcaatcatgt actagctctc aagtatctag 45480
ttagcaattt tcctcaacac gttattacta aggatgtatt agctaatacc aatttttttg 45540
ttttcataca tatggtacga tgttgtaaag tgtacgaagc ggttttacga cacgcatttg 45600
atgcacccac gttgtacgtt aaagcattga ctaagaatta tttatcgttt agtaacgcaa 45660
tacaatcgta caaggaaacc gtgcataaac taacacaaga tgaaaaattt ttagaggttg 45720
ccgaatacat ggacgaatta ggagaactta taggcgtaaa ttatgactta gttcttaatc 45780
cattatttca cggaggggaa cccatcaaag atatggaaat cattttttta aaactgttta 45840
agaaaacaga cttcaaagtt gttaaaaaat taagtgttat aagattactt atttgggctt 45900
acctaagcaa gaaagataca ggcatagagt ttgcggataa tgatagacaa gatatataca 45960
ctctatttca acaaactggt agaatagtcc atagcaatct aacagaaacg tttagagatt 46020
atatctttcc cggagataag actagctatt gggtgtggtt aaacgaaagt atagctaatg 46080
atgcggatat tgttcttaat agacacgcca ttaccatgta tgataaaatt cttagttata 46140
tatactctga gataaaacaa ggacgcgtta ataaaaacat gcttaagtta gtttatatct 46200
ttgagcctga aaaagatatc agagaacttc tgctagaaat catatatgat attcctggag 46260
atatcctatc tattattgat gcaaaaaacg acgattggaa aaaatatttt attagttttt 46320
ataaagctaa ttttattaac ggtaatacat ttattagtga tagaacgttt aacgaggact 46380
tattcagagt tgttgttcaa atagatcccg aatatttcga taatgaacga attatgtctt 46440
tattctctac gagtgctgcg gacattaaac gatttgatga gttagatatt aataacagtt 46500
atatatctaa tataatttat gaggtgaacg atatcacatt agatacaatg gatgatatga 46560
agaagtgtca aatctttaac gaggatacgt cgtattatgt taaggaatac aatacatacc 46620
tgtttttgca cgagtcggat cccatggtca tagagaacgg aatactaaag aaactgtcat 46680
ctataaaatc caagagtaga cggctgaact tgtttagcaa aaacatttta aaatattatt 46740
tagacggaca attggctcgt ctaggtcttg tgttagatga ttataaagga gacttgttag 46800
ttaaaatgat aaaccatctt aagtctgtgg aggatgtatc cgcattcgtt cgattttcta 46860
cagataaaaa ccctagtatt cttccatcgc taatcaaaac tattttagct agttataata 46920
tttccatcat cgtcttattt caaaggtttt tgagagataa tctatatcat gtagaagaat 46980
tcttggataa aagcatccat ctaaccaaga cggataagaa atatatactt caattgataa 47040
gacacggtag atcatagaac agaccaaata tattattaat aatttgtata tacatagata 47100
taattatcac acatttttga taaatgggaa ctgctgcaac aattcagact cccaccaaat 47160
taatgaataa agaaaatgca gaaatgattt tggaaaaaat tgttgatcat atagttatgt 47220
atattagtga cgaatcaagt gattcagaaa ataatcctga atatattgat tttcgtaaca 47280
gatacgaaga ctatagatct ctcattataa aaagtgatca cgagtttgta aagctatgta 47340
aaaatcatgc agagaaaagt tctccagaaa cgcaacaaat gattatcaaa cacatatacg 47400
aacaatatct tattccagta tctgaagtac tattaaaacc tataatgtcc atgggtgaca 47460
taattacata taacggatgt aaagacaatg aatggatgct agaacaactc tctaccctaa 47520
actttaacaa tctccgcaca tggaactcat gtagcatagg caatgtaacg cgtctgtttt 47580
atacattttt tagttatctg atgaaagata aactaaatat ataagtataa tcccattcta 47640
atactttaac ctgatgtatt acctgcatct tattagaata ttaacctaac taaaagacat 47700
aacatagttg ataaaaagcg gtaggatata aatattatgg ctgccaccgt tccgcgtttt 47760
gacgacgtgt acaaaaatgc acaaagaaga attctagatc aagaaacatt ttttagtaga 47820
ggtctaagta gaccgttaat gaaaaacaca tatctatttg ataattacgc gtatggatgg 47880
ataccagaaa ctgcaatttg gagtagtaga tacgcaaact tagatgcaag tgactattat 47940
cccatttcgt tgggattact taaaaagttc gagtttctca tgtctctata taaaggtcct 48000
attcccgtat atgaagaaaa agtaaatact gaattcattg ctaatggatc gttctctggt 48060
agatacgtat catatcttcg aaagttttct gcccttccaa caaacgagtt tattagtttt 48120
ttgttactga cttccattcc aatctataat atcttgttct ggtttaaaaa tactcagttt 48180
gatattacta aacacacatt attcagatac gtctatacag ataatgccaa acacctggcg 48240
ttggctaggt atatgcatca aacaggagac tataagcctt tgtttagtcg tctcaaagag 48300
aattatatat ttaccggtcc cgttccaata agtatcaaag atatagatca ccctaatctt 48360
agtagagcaa gaagtccatc cgattatgag acattagcta atattagtac tatattgtac 48420
tttaccaagt atgatccggt attaatgttt ttattgtttt acgtacctgg gtattcaatt 48480
actacaaaaa ttactccagc cgtagaatat ctaatggata aactgaatct aacaaagagc 48540
gacgtacaac tgttgtaaat tattttatgc ttcgtaaaat gtaggttttg aaccaaacat 48600
tctttcaaag aatgagatgc ataaaacttt attatccaat agattgacta tttcggacgt 48660
caatcgttta aagtaaactt cgtaaaatat tctttgatca ctgccgagtt taaaacttct 48720
atcgataatt gtttcatatg ttttaatatt tacaagtttt ttggtccatg gtacattagc 48780
cggacaaata tatgcaaaat aatatcgttc tccaagttct atagtttctg gattattttt 48840
attatattca gtaaccaaat acatattagg gttatctgcg gatttataat ttgagtgatg 48900
cattcgactc aacataaata attctagagg agacgatcta ctatcaaatt cggatcgtaa 48960
atctgtttct aaagaacgga gaatatctat acatacctga ttagaattca tccgtccttc 49020
agacaacatc tcagacagtc tggtcttgta tgtcttaatc atattcttat gaaacttgga 49080
aacatctctt ctagtttcac tagtaccttt attaattctc tcaggtacag attttgaatt 49140
cgacgatgct gagtatttca tcgttgtata tttcttcttc gattgcataa tcagattctt 49200
atataccgcc tcaaactcta ttttaaaatt attaaacaat actctattat taatcagtcg 49260
ttctaactct ttcgctattt ctatagactt atcgacatct tgactgtcta tctctgtaaa 49320
cacggagtcg gtatctccat acacgctacg aaaacgaaat ctgtaatcta taggcaacga 49380
tgttttcaca atcggattaa tatctctatc gtccatataa aatggattac ttaatggatt 49440
ggcaaaccgt aacataccgt tagataactc tgctccattt agtaccgatt ctagatacaa 49500
gatcattcta cgtcctatgg atgtgcaact cttagccgaa gcgtatgagt atagagcact 49560
atttctaaat cccatcagac catatactga gttggctact atcttgtacg tatattgcat 49620
ggaatcatag atggcctttt cagttgaact ggtagcctgt tttagcatct ttttatatct 49680
ggctctctct gccaaaaatg ttcttaatag tctaggaatg gttccttcta tcgatctatc 49740
gaaaattgct atttcagaga tgaggttcgg tagtctaggt tcacaatgaa ccgtaatata 49800
tctaggaggt ggatatttct gaagcaagag ctgattattt atttcttctt ccaatctatt 49860
ggtactaaca acgacaccga ctaatgtttc cggagataga tttccaaaga tacacacatt 49920
aggatacaga ctgttataat caaagattaa tacattatta ctaaacattt tttgttttgg 49980
agcaaatacc ttaccgcctt cataaggaaa cttttgtttt gtttctgatc taactaagat 50040
agttttagtt tccaacaata gctttaacag tggacccttg atgactgtac tcgctctata 50100
ttcgaatacc atggattgag gaagcacata tgttgacgca cccgcgtctg tttttgtttc 50160
tactccataa tactcccaca aatactgaca caaacaagca tcatgaatac agtatctagc 50220
catatctaaa gctatgttta gattataatc cttatacatc tgagctaaat caacgtcatc 50280
ctttccgaaa gataatttat atgtatcatt aggtaaagta ggacatgata gtacgacttt 50340
aaatccattt tcccaaatat ctttacgaat tactttacat ataatatcct catcaacagt 50400
cacataatta cctgtggtta aaacctttgc aaatgcagcg gctttgcctt tcgcgtccgt 50460
agtatcgtca ccgatgaacg tcatttctct aactcctcta tttaatactt tacccatgca 50520
actgaacgcg ttcttggata tagaatccaa tttgtacgaa tccaattttt cagatttttg 50580
aatgaatgaa tatagatcga aaaatatagt tccattattg ttattaacgt gaaacgtagt 50640
attggccatg ccgcctactc ccttatgact agactgattt ctctcataaa tacagagatg 50700
tacagcttcc tttttgtccg gagatctaaa gataatcttc tctcctgtta ataactctag 50760
acgattagta atatatctca gatcaaagtt atgtccgtta aaggtaacga cgtagtcgaa 50820
cgttagttcc aacaattgtt tagctattcg taacaaaact atttcagaac atagaactag 50880
ttctcgttcg taatccattt ccattagtga ctgtatcctc aaacatcctc tatcgacggc 50940
ttcttgtatt tcctgttccg ttaacatctc ttcattaatg agcgtaaaca ataatcgttt 51000
accacttaaa tcgatataac agtaacttgt atgcgagatt gggttaataa atacagaagg 51060
aaacttctta tcgaagtgac actctatatc tagaaataag tacgatcttg ggatatcgaa 51120
tctaggtatt tttttagcga aacagttacg tggatcgtca caatgataac atccattgtt 51180
aatctttgtc aaatattgct cgtccaacga gtaacatccg tctggagata tcccgttaga 51240
aatataaaac caactaatat tgagaaattc atccatggtg gcattttgta tgctgcgttt 51300
ctttggctct tctatcaacc acatatctgc gacggagcat tttctatctt taatatctag 51360
attataactt attgtctcgt caatgtctat agttctcatc tttcccaacg gcctcgcatt 51420
aaatggagga ggagacaatg actgatatat ttcgtccgta actacgtaat aaaagtaatg 51480
aggaaatcgt ataaatacgg tctcgccatt tcgacatctg gatttcagat ataaaaatct 51540
gttttcaccg tgactttcaa accaattaat gcaccgaaca tccatttata gaatttagaa 51600
atatattttc atttaaatga atcccaaaca ttggggaaga gccgtatgga ccattatttt 51660
tatagtactt tcgcaagcgg gtttagacgg caacatagaa gcgtgtaaac gaaaactata 51720
tactatagtc agcactcttc catgtcctgc atgtagacgg cacgcgacta tcgctataga 51780
ggacaataat gtcatgtcta gcgatgatct gaattatatt tattattttt tcatcagatt 51840
atttaacaat ttggcatctg atcccaaata cgcgatcgat gtgacaaagg ttaacccttt 51900
ataaacttaa cccattataa aacttatgat tagtcacgac tgaaataacc gcgtgattat 51960
tttttggtat aattctacac ggcatggttt ctgtaactat gaattcaacc cccgttacat 52020
tagtgaaatc tttaacaaac agcaagggtt cgtcaaagac ataaaactca ttgtttacaa 52080
tcgaaataga ccccctatca cacttaaaat aaaaaatatc cttatccttt accaccaaat 52140
aaaattctga ttggtcaatg tgaatgtatt cacttaacag ttccacaaat ttatttatta 52200
actccgaggc acatacatcg tcggtatttt ttatggcaaa ctttactctt ccagcatccg 52260
tttctaaaaa aatattaacg agttccattt atatcatcca atattattga aatgacgttg 52320
atggacagat gatacaaata agaaggtacg gtacctttgt ccaccatctc ctccaattca 52380
tgctctattt tgtcattaac tttaatgtat gaaaacagta cgccacatgc ttccatgaca 52440
gtgtgtaaca ctttggatac aaaatgtttg acattagtat aattgtccaa gactgtcaat 52500
ctataataga tagtagctat aatatattct atgatggtat tgaagaagat gacaatcttg 52560
gcatattgat catttaacac agacatggta tcaacagata gcttgaatga aagagaatca 52620
gtaattggaa taagcgtctt ctcgatagag tgtccgtata ccaacatgtc tgatattttg 52680
atgtattcca ttaaattatt tagttttttc tttttattct cgttaaacag catttctgtc 52740
aacggacccc aacatcgttg accgattaag ttttgattga tttttccgtg taaggcgtat 52800
ctagtcagat cgtatagcct atccaataat ccatcatctg tgcgtagatc acatcgtaca 52860
ctttttaatt ctctatagaa gagcgacaga cagcaatttc tttattctct acagatgtaa 52920
gatacttgaa gacattccta tgatgatgca gaattttgga taacacggta ttgatggtat 52980
ctgttaccat aattcctttg atggctgata gtgtcagagc acaagatttc caatctttgt 53040
tttgatatct atatcagaca gcatggtgcg tctgacaaca caaggattaa gacggaaaga 53100
tgaaatgatt ctctcaacat cttcaatgga taccttgcta ttttttctgg cattatctat 53160
atgtgcgaga atatcctcta gagaatcagt atcctttttg atgatagtgg atctcaatga 53220
catgggacgt ctaaaccttc ttattctatc accagattgc atggtgattt gtcttctttc 53280
ttttatcata atgtaatctc taaattcatc ggcaaattgt ctatatctaa aatcataata 53340
tgagatgttt acctctacaa atatctgttc gtccaatgtt agagtatcta catcagtttt 53400
gtattccaaa ttaaacatgg caacggattt aattttatat tcctctatta agtcctcgtc 53460
gataataaca gaatgtagat aatcatttaa tccatcgtac atggttggaa gatgcttgtt 53520
gacaaaatct ttaattgtct tgatgaaggt gggactatat ctaacatctt gattaataaa 53580
atttataaca ttgtccatag gatactttgt aactagtttt atacacatct cttcatcggt 53640
aagtttagac agaatatcgt gaacaggtgg tatattatat tcatcagata tacgaagaac 53700
aatgtccaaa tctatattgt ttaatatatt atatagatgt agcgtagctc ctacaggaat 53760
atctttaact aagtcaatga tttcatcaac cgttagatct attttaaagt taatcatata 53820
ggcattgatt tttaaaaggt atgtagcctt gactacattc tcattaatta accattccaa 53880
gtcactgtgt gtaagaagat tatattctat cataagcttg actacatttg gtcccgatac 53940
cattaaagaa ttcttatgat ataaggaaac agattttagg tactcatcta ctctacaaga 54000
attttggaga gccttaacga tatcagtgac gtttattatt tcaggaggaa agaatctaac 54060
attgagaata tcggaattaa tagcttccag atacagtgat tttggcaata gtccgtgtaa 54120
tccataatcc agtaacacga gctggtgctt gctagacacc ttttcaatgt ttaatttttt 54180
tgaaataagc tttgataaag ccttcctcgc aaattccgga tacatgaaca tgtcggcgac 54240
atgattaagt attgtttttt cattattttc tcaacaagtt ctcaataccc caatagatga 54300
tagaatatca cccaatgcgt ccatgttgtc tatttccaac aggtcgctat atccaccaat 54360
agaagttttt ccaaaaaaga ttctaggaac agttctacca ccagtaattt gttcaaaata 54420
gtcacgcaat tcattttcgg gtttaaattc tttaatatcg acaatttcat acgctcctct 54480
tttgaaacta aacttattta gaatatccag tgcatttcta caaaaaggac atgtatactt 54540
gacaaaaatt gtcactttgt tattggccaa cctttgttgt acaaattcct cggccatttt 54600
aatatttaag tgatataaaa ctatctcgac ttatttaact ctttagtcga gatatatgga 54660
cgcagatagc tatatgatag ccaactacag aaggcaaacg ctataaaaaa cataattacg 54720
acgagcatat ttataaatat ttttattcag cattacttga tatagtaata ttaggcacag 54780
tcaaacattc aaccactctc gatacattaa ctctctcatt ttctttaaca aattctacaa 54840
tatcttcgta aaaagattct tgaaactttt tagaatatct atcgactcta gatgaaatag 54900
cgttcgtcaa catactatgt tttgtataca taaaggcgcc cattttaaca gtttctagtg 54960
acaaaatgct agcgatccta ggatccttta gaatcacata gattgacgat tcgtctctct 55020
tagtaactct agtaaaataa tcatacaatc tagtacgcga aataatatta tccttgactt 55080
gaggagatct aaacaatcta gttttgagaa catcgataag ttcatcggga atgacataca 55140
tactatcttt aatagaactc ttttcatcca gttgaatgga ttcgtcctta accaactgat 55200
taatgagatc ttctatttta tcattttcca gatgatatgt atgtccatta aagttaaatt 55260
gtgtagcgct tctttttagt ctagcagcca atactttaac atcactaata tcgatataca 55320
aaggagatga tttatctatg gtattaagaa ttcgtttttc gacatctgtc aaaaccaatt 55380
cctttttgcc tgtatcatcc agttttccat cctttgtaaa gaaattattt tctactagac 55440
tattaataag actgataagg attcctccat aattgcacaa tccaaacttt ttaacaaaac 55500
tagactttac aagatctaca ggaatgcgta attcaggttt cttagcttgt gattttttct 55560
tttgtggaca ttttcttgtg accaactcat ctaccatttc attgatttta gcagtgaaat 55620
aagctttcaa tgcacgggca ctgatactat tgaaaacgag ttgatcttca aattccgcca 55680
tttaagttca ccaaacaact tttaaataca aatatatcaa tagtagtaga ataagaacta 55740
taaaaaaaat aataattaac caataccaac cccaacaacc ggtattatta gttgatgtga 55800
ctgttttctc atcacttaga acagatttaa caatttctat aaagtctgtc aaatcatctt 55860
ccggagaccc cataaataca ccaaatatag cggcgtacaa cttatccatt tatacattga 55920
atattggctt ttctttatcg ctatcttcat catattcatc atcaatatca acaagtccca 55980
gattacgagc cagatcttct tctacatttt cagtcattga tacacgttca ctatctccag 56040
agagtccgat aacgttagcc accacttctc tatcaatgat tagtttcttg agtgcgaatg 56100
taatttttgt ttccgttccg gatctataga agacgatagg tgtgataatt gccttggcca 56160
attgtctttc tcttttactg agtgattcta gttcaccttc tatagatctg agaatggatg 56220
attctccagt cgaaacatat tctaccatgg atccgtttaa tttgttgatg aagatggatt 56280
catccttaaa tgttttctct gtaatagttt ccaccgaaag actatgcaaa gaatttggaa 56340
tgcgttcctt gtgcttaatg tttccataga cggcttctag aagttgatac aacataggac 56400
tagccgcggt aacttttatt tttagaaagt atccatcgct tctatcttgt ttagatttat 56460
ttttataaag tttagtctct ccttccaaca taataaaagt ggaagtcatt tgactagata 56520
aactatcagt aagttttata gagatagacg aacaattagc gtattgagaa gcatttagtg 56580
taacgtattc gatacatttt gcattagatt tactaatcga ttttgcatac tctataacac 56640
ccgcacaagt ctgtagagaa tcgctagatg cagtaggtct tggtgaagtt tcaactctct 56700
tcttgattac cttactcatg attaaaccta aataattgta ctttgtaata taatgatata 56760
tattttcact ttatctcatt tgagaataaa aatgtttttg tttaaccact gcatgatgta 56820
cagatttcgg aatcgcaaac caccagtggt tttattttat ccttgtccaa tgtgaattga 56880
atgggagcgg atgcgggttt cgtacgtaga tagtacattc ccgtttttag accgagactc 56940
catccgtaaa aatgcatact cgttagtttg gaataactcg gatctgctat atggatattc 57000
atagattgac tttgatcgat gaaggctccc ctgtctgcag ccatttttat gatcgtcttt 57060
tgtggaattt cccaaatagt tttataaact cgcttaatat cttctggaag gtttgtattc 57120
tgaatggatc caccatctgc cataatccta ttcttgatct catcattcca taattttctc 57180
tcggttaaaa ctctaaggag atgcggatta actacttgaa attctccaga caatactctc 57240
cgagtgtaaa tattactggt atacggttcc accgactcat tatttcccaa aatttgagca 57300
gttgatgcag tcggcatagg tgccaccaat aaactatttc taagaccgta tgttctgatt 57360
ttatctttta gaggttccca attccaaaga tccgacggta caacattcca aagatcatat 57420
tgtagaatac cgttactggc gtacgatcct acatatgtat cgtatggtcc ttccttctca 57480
gctagttcac aactcgcctc taatgcaccg taataaatgg tttcgaagat cttcttattt 57540
agatcttgtg cttccaggct atcaaatgga taatttaaga gaataaacgc gtccgctaat 57600
ccttgaacac caataccgat aggtctatgt ctcttattag agatttcagc ttctggaata 57660
ggataataat taatatctat aattttattg agatttctga caattacttt gaccacatcc 57720
ttcagtttga gaaaatcaaa tcgcccatct attacaaaca tgttcaaggc aacagatgcc 57780
agattacaaa cggctacctc attagcatcc gcatattgta ttatctcagt gcaaagatta 57840
ctacacttga tagttcctaa attttgttga ttactctttt tgttacacgc atccttataa 57900
agaatgaatg gagtaccagt ttcaatctga gattctataa tcgctttcca gacgactcga 57960
gcctttatta tagatttgta tctcctttct ctttcgtata gtgtatacaa tcgttcgaac 58020
tcgtctcccc aaacattgtc caatccagga cattcatccg gacacatcaa cgaccactct 58080
ccgtcatcct tcactcgttt cataaagaga tcaggaatcc aaagagctat aaatagatct 58140
ctggttctat gttcctcgtt tcctgtattc tttttaagat cgaggaacgc cataatatca 58200
gaatgccacg gttccaagta tatggccata actccaggcc gtttgtttcc tccctgatct 58260
atgtatctag cggtgttatt ataaactctc aacattggaa taataccgtt tgatatacca 58320
ttggtaccgg agatatagct tccactggca cgaatattac taattgatag acctattccc 58380
cctgccattt tagagattaa tgcgcatcgt tttaacgtgt catagatacc ctctatgcta 58440
tcatcgatca tgttaagtag aaaacagcta gacatttggt gacgactagt tcccgcatta 58500
aataaggtag gagaagcgtg cgtaaaccat ttttcagaaa gtagattgta cgtctcaata 58560
gctgagtcta tatcccattg atgaattcct actgcgacac gcattaacat gtgctgaggt 58620
ctttcaacga tcttgttgtt tattttcaac aagtaggatt tttccaaagt tttaaaacca 58680
aaatagttgt atgaaaagtc tcgttcgtaa ataataaccg agttgagttt atccttatat 58740
ttgttaacta tatccatggt gatacttgaa ataatcggag aatgtttccc atttttagga 58800
ttaacatagt tgaataaatc ctccatcact tcactaaata gtttttttgt ttccttgtgt 58860
agatttgata cggctattct ggcggctaga atggcataat ccggatgttg tgtagtacaa 58920
gtggctgcta tttcggctgc cagagtgtcc aattctaccg ttgttactcc attatatatt 58980
ccttgaataa ccttcatagc tattttaata ggatctatat gatccgtgtt taagccataa 59040
cataattttc taatacgaga cgtgatttta tcaaacatga cattttcctt gtatccattt 59100
cgtttaatga caaacatttt tgttggtgta ataaaaaaaa ttatttaact tttcattaat 59160
agggatttga cgtatgtagc gtacaaaatt atcgttcctg gtatatagat aaagagtcct 59220
atatatttga aaatcgttac ggctcgatta aactttaatg attgcatagt gaatatatca 59280
ttaggattta actccttgac tatcatggcg gcgccagaaa ttaccatcaa aagcattaat 59340
acagttatgc cgatcgcagt tagaacggtt atagcatcca ccatttatat ctaaaaatta 59400
gatcaaagaa tatgtgacaa agtcctagtt gtatactgag aattgacgaa acaatgtttc 59460
ttacatattt tttttttatt agtaaccgac ttaatagtag gaactggaaa actagacttg 59520
attattctat aagtatagat acccttccaa ataatattct ctttgataaa agttccagaa 59580
aatgtagaat tttttaaaaa gttatctttt gctattacca agattgtgtt tagacgctta 59640
ttattaatat gagtgatgaa atccacaccg cctctagata tcgcttttat ttccacatta 59700
gatggtaaat ccaatagtga aactatcttt ttaggaatgt atggactcgc gtttagagga 59760
gtgaacgtct taggcgtcgg aaaggggccg gccttttttt ctagacacta aataaatagt 59820
aagattaaat taattataaa attatgtata taatattaat tataaaatta tgtatatgat 59880
ttactaactt tagttagata aattaataat acataaattt tagtatatta atattataaa 59940
ttaataatac ataaatttta gtatattaat attatatttt aaatatttat ttagtgtcta 60000
gaaaaaaagg cctagcaggc c 60021
<210> 12
<211> 60021
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA fragment F1
<400> 12
ggcctagcag gccggccttt ttttctagac actaaataaa tagtaagatt aaattaatta 60
taaaattatg tatataatat taattataaa attatgtata tgatttacta actttagtta 120
gataaattaa taatacataa attttagtat attaatatta taaattaata atacataaat 180
tttagtatat taatattata ttttaaatat ttatttagtg tctagaaaaa aatgtgtgac 240
caacgaccgt aggaaactct agagggtaag aaaaatcaat cgctttatag agaccatcag 300
aaagaggttt aatatttttg tgagaccatc gaaggagaaa gagataaaac ttttttacga 360
ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac 420
ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa 480
gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg 540
aaggagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 600
agaccatcga aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat 660
atttttgtga gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag 720
aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 780
catcagaaag aggtttaata tttttgtgag accatcgaag gagaaagaga taaaactttt 840
ttacgactcc atcagaaaga ggtttaatat ttttgtgaga ccatcgaaga gagaaagaga 900
ataaaaatat tttagtgaca ccatcagaaa gaggtttaat atttttgtga gaccatcgaa 960
gagagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 1020
gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag aggtttaata 1080
tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc catcagaaag 1140
aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 1200
catcagaaag accatcgaag agagaaagag aaagagatag ttagtctaga tatttttctt 1260
agtacaaaag tcaatgtttt aaaatatatg gacaagaatt tgtctgtata aaaacttgtg 1320
tgaaattttg taccaaagaa aaaatgtgag cagtatcccc tacatggatt ttactagatc 1380
atttatatac caaaaaatat tatacgatct acgttttatt atatgatttt aacgtgtaaa 1440
ttataaacat tattttatga tatacaattg tctggtaacc tagatgggca taggggatga 1500
gtatatgttg ttggacgtta ttgtttaaga aatagttgat gcatcagaaa gaggtttaat 1560
atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttacgact ccatcagaaa 1620
gaggtttaat atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttatgact 1680
ccattgaaga gagaatgaga ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1740
attttttatg agaccatcaa agagagaaag agaataaaaa tattttatga ctccattgaa 1800
gagagaaaga gaaaatgaga ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1860
attttttatg agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt 1920
tatgagacca tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag 1980
accatcaaag agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc 2040
aaagagagaa agagaataaa aatatttttg taaaactttt tttatgagac catcaaagag 2100
agaaagagaa taaaaatatt tttgtaaaac tttttttatg agaccatcaa agagagaaag 2160
agaataaaaa tatttttgta aaactttttt tatgagacca tcaaagagag aaagagaata 2220
aaaatatttt tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata 2280
ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca ccatcagaaa 2340
gaggtttaat atttttgtga gaccatcgaa gagagaaaga gaataaaaat attttatgac 2400
tccattgaag agagaaagag aataaaaata ttttagtgac accatcagaa agaggtttaa 2460
tattttttat gagaccatca aagagagaaa gagaataaaa atatttttgt aaaacttttt 2520
ttatgagacc atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga 2580
gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 2640
caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 2700
gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 2760
gagaataaaa atattttatg actccattga agagagaatg agaataaaaa tattttagtg 2820
acaccatcag aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa 2880
aatattttat gactccattg aagagagaaa gagaataaaa atattttagt gacaccatca 2940
gaaagaggtt taatattttt tatgagacca tcaaagagag aaagagaata aaaatatttt 3000
tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 3060
acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 3120
tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 3180
agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 3240
tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag accatcaaag 3300
agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc aaagagagaa 3360
agagaataaa aatattttat gactccattg aagagagaat gagaataaaa atattttagt 3420
gacaccatca gaaagaggtt taatattttt gtgagaccat cgaagagaga aagagaataa 3480
aaatatttta tgactccatt gaagagagaa tgagaataaa aatattttag tgacaccatc 3540
agaaagaggt ttaatatttt ttatgagacc atcaaagaga gaaagagaat aaaaatattt 3600
ttgtaaaact ttttttatga gaccatcaaa gagagaaaga gaataaaaat atttttgtaa 3660
aaattataaa cattatttta tgatatacaa ttgtctggta acctagatgg gcatagggga 3720
tgttgataag ctcgacgagt atatgttgtt ggacgttatt gtttaagaaa tagttgatgc 3780
atcagaaaga gaataaaaaa tattttagtg agaccatcga agagagaaag agataaaact 3840
tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 3900
agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 3960
aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 4020
gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 4080
caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 4140
gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 4200
gagaataaaa atatttttgt aaaacttttt ttatgagacc atcaaagaga gaaagagaat 4260
aaaaatattt tatgactcca ttgaagagag aatgagaata aaaatatttt agtgacacca 4320
tcagaaagag gtttaatatt tttgtgagac catcgaagag agaaagagaa taaaaatatt 4380
ttatgactcc attgaagaga gaatgagaat aaaaatattt tagtgacacc atcagaaaga 4440
ggtttaatat tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 4500
acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 4560
tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 4620
agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 4680
tcaaagagag aaagagaata aaaatatttt atgactccat tgaagagaga atgagaataa 4740
aaatatttta gtgacaccat cagaaagagg tttaatattt ttgtgagacc atcgaagaga 4800
gaaagagaat aaaaatattt tatgactcca ttgaagagag aaagagaata aaaatatttt 4860
agtgacacca tcagaaagag gtttaatatt ttttatgaga ccatcaaaga gagaaagaga 4920
ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa gagaataaaa 4980
atattttatg actccattga agagagaatg agaataaaaa tattttagtg acaccatcag 5040
aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa aatattttat 5100
gactccattg aagagagaat gagaataaaa atattttagt gacaccatca gaaagaggtt 5160
taatattttt gtgagaccat cgaagagaga aagagaataa aaatatttta tgactccatt 5220
gaagagagaa tgagaataaa aatattttag tgacaccatc agaaagaggt ttaatatttt 5280
ttatgagacc atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga 5340
gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 5400
caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 5460
gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat 5520
ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga 5580
gagaaagaga ataaaaatat tttatgactc cattgaagag agaaagagaa taaaaatatt 5640
ttagtgacac catcagaaag aggtttaata tttttgtgag accatcgaag agagaaagag 5700
aataaaaata ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca 5760
ccatcagaaa gaggtttaat attttttatg agaccatcaa agagagaaag agaataaaaa 5820
tattttttat gagaccatca aagagagaaa gagaataaaa atattttatg agaccatcaa 5880
agagagaaag agaataaaaa tattttttat gagaccatca aagagagaaa gagaataaaa 5940
atattttatg agaccatcaa agagagaaag agaataaaaa tattttttat gagaccatca 6000
aagagagaaa gagaataaaa atatttttgt atgagaccat cagaaagagg tttaatattt 6060
ttgtgatacc ctgaaaggaa ataggaatag tgtcataatc gtatcacact attgagacag 6120
aaaaagaaga agtcgcgaga ggtaactttt tgttttgcaa accggaatat agtgtccggt 6180
acactttttt aattcgtggt gtgcctgaat cgttcgatta accctactca tccaatttca 6240
gatgaataga gttatcgatt cagacacacg ctttgagttt tgttgaatcg atgagtgaag 6300
tatcatcggt tgcaccttca gatgccgatc cgtcgacata cttgacctca agttcagatg 6360
attccttgca catgtctccg atacgaacgc taaactctag attcttgaca cattttgtat 6420
cgacgatcgt tgaaccgatg atatcttcgt aactcacttt cttatgagag atgttagacc 6480
cgagtactgg atgggtcttg atgtcgctgt ctttctcttc ttcgctacat ctgatgtcga 6540
tagacacctc acagtctttc catcagcgga ttctgagatg gatttaatct gaggacattt 6600
ggtgaatcca aagttcattc tcagacctcc accgatgatg gagtaataag tggtaggagg 6660
atctacatcc tcgactgatt ccacctcggg atctggatct gactcggact ctgtaatttc 6720
cgttacggat tggcaaatct tatcatcggt cggtgtttgg tcttgctttg tgactttgat 6780
aataacatcg attcccatat gatgtttgtt ttcttcttcc gtacacgatg aggatgattg 6840
ctgaagactg gcaggcacat gcatgccagt acgatatatt gtttcatgat tgctattgat 6900
tgagtactgt tctttatgat tctacttcct taccgtgcaa taaattagaa tatattttct 6960
acttttacga gaaattaatt attgtattta tgggtgaaaa acttactata aaaagcgggt 7020
gggtttggaa ttagtgatca gtttatgtat atcgcaacta ccgggcatat ggctacatta 7080
cccacatgat aagagattgt atcagtttcg tagtcttgag tattggtatt actatatagt 7140
atatagatgt cgacgctaga gttactgtct ccgaatgcgg catgatagta tcattctttg 7200
ctttcgttaa ctgtttggag gaagaatctt tgttattgca tttaatctcg aaattcagag 7260
tgcacacctt tctcctgtaa agaaacctga agtcgctacc ttattaagaa gacgggatcg 7320
cagtctttat gattcatagt aatagttagt tccgacgttg agatggattc gctgagaccg 7380
gtagtggtcg tccgagtaca cgatgtgtcg ttaactggat acaggttaat ttccacatcg 7440
atatagttaa aggtatttct gggtacgggt tcgcatttat ctgcggaaga gacggtgtga 7500
gaatatgttc cgagaccaca cggagaacag atgacgtctc cggatactcc gtatcctatt 7560
ccacattttg tttgggaaac acatgccttg catccatgat cgggagagca ttcacagatt 7620
ctattgtgag tcgtgttaca cgatcgcgtc gacattgttg acagaaacgt gaccttcatt 7680
cttaccgtcg tccataaata cgttaggtat gtaccacata ctgtcgcgaa cgatgcgtcc 7740
atctcataat gatttacttt ttcataatta aagatgtgaa agaaaaccga acaatatatt 7800
tttttagtaa tgtttatgcg agacatataa aataaactcc gtgtttatga tgccggtaaa 7860
tgtttttatc atcttggacg gaatcgattt tgtaatatgc catggaaaca ggacattatc 7920
actccatgat aaattattta atggagtcga tcctctcatt gttctttgcg tatctcaatc 7980
tgtggcgttt gcttcgttta aataatatat caaacatgga gacgcctgat atgtaggcat 8040
tcttcattct attaatgtct gctctatagc gctttagttc cttatgacga ccggcgatat 8100
catacttact ttagaaggaa aatcatcatc taggattaag gcgtatctga tacaggcgaa 8160
taatggttca ggatatagat agcgtatatc tctattaaat gcgtcaatca tagtctctag 8220
agtgggatgg taactcagta ataaatcaac tagcttctct ttggtaactg cttttctgga 8280
tggccgtatt gattatcgag cgtgacactc gctccatatt ccaataaccg ctttgcaaat 8340
tgtatattat tgacatcgac cgcgtaatat agtagagtta tcgatcatat ctatatcatc 8400
catgtacttg cttagtatat caaatacatc ttcataacag tgatacccgc aattattaaa 8460
tctcgataat atcagaccgt acatacatag acggccattg ttagatatgt gatttacagc 8520
cgcgtgtcca tattttccac gataaacctt acgacgttta catcgacgag attattatta 8580
acaaagttgt tgtccgtcgt cttatccaac atgcattgaa tgataggtat acttaccata 8640
tcgccgtaat gtaagtagtt tatcagtatg gcttgtacga tggattcatc ctgttgtcta 8700
aatctcttta gaatgttatc gatgatgtag tggttatatt ctctggaatc gtacgaagta 8760
atactacgca ttacgtcgac aagagtatga cgtctctcaa taagaagatt aacgatttcc 8820
atgtctacat tatatggggt tactctaaat cgcttgttta gataatacgc ctctaatata 8880
gggctgacgt cgtatactct acacgtgtcc acatccttta ttaataatct ctatatctat 8940
ggttgagcaa gaccagtagt attggatgga aacattgtta tcgatcaaac atttaattac 9000
atccttggat agagattctc tatgagacga tatatagtaa tgaagagagt tcttacacat 9060
atcactgttg tacatacagg tacgaaatac gtaaccggtg ctgtaacatt ctgatttaag 9120
aagccatagc aatacttctg gtctcggatt aggcgtcgtt acgtatatat ccaccaatcc 9180
gagaccattg attgcataat tcgtattctt ggacggacgt atccgtttat ccacaattag 9240
gtattttagc agacgtaagt cgaaatcatt tatattcgac ttgagttcgt tagaggaatt 9300
cgaatagctg gatatcagta gatgcacaat ctgagatttt acgtatctat gcttactgta 9360
tgctcctagc ggagttaatc cttcgttgtt tctacaaagt ctctcgactc cgcgagagag 9420
taacagtcga acaatcttaa tgtctgtatc gcatttattg gagacgtaac aatgtagcgc 9480
attgtttcct cgtctatcta tatgttttga taagttgtga cacgtttcaa tttctagttt 9540
tatttttttg tacgtcacat cttcatccag tagacgacat agaatacatg tgcaatccat 9600
agctattctg gtgctaatta ttcctcataa gatgataaaa agtgtagtga gagagcatga 9660
aggagattta gtatttagca gtgcggatat gatccaagag ggtgagatag tcgttctcgt 9720
tcagaatctt tcgcagcata agtagtatgt cgatatactt atcgttgaag actcttccag 9780
agacgatagc tgattgagta caaagtccaa tgattgcacg aagttcttcg gcggttttca 9840
tggagtcatt tctgatgaaa catttaatga tctaaatttc agtttatgtt tgtaccccgt 9900
attcatactt aacaaattgg tattacatac cattaataat gcaagcataa aaaatcgtta 9960
gtagatgttt ctaaatatag gttccgtaag caaagaatat aagaatgaag cggtaatgat 10020
aaaatcaatc gttatctaaa atgatcatac tcatttattt tattctatta tattaacaca 10080
tacattttta acagcaacac attcaatatt gtattgttat ttttatatta tttacacaat 10140
taacaatata ttattagttt atattactga attaataata taaaattccc aatcttgtca 10200
taaacacaca ctgagaaaca gcataaacac aaaatccatc aaaaatgttg ataaattatc 10260
tgatgttgtt gttcgctgct atgataatca gatcattcgc cgatagtggt aacgctatcg 10320
aaacgacatc gccagaaatt acaaacgcta caacagatat tccagctatc agattatgcg 10380
gtccagaggg agatggatat tgtttacacg gtgactgtat ccacgctaga gatatcgacg 10440
gtatgtattg tagatgctct catggttata caggcattag atgtcagcat gtagtattag 10500
tagactatca acgttcagaa aaaccaaaca ctacaacgtc atatatccca tctcccggta 10560
ttatgcttgt attagtaggc attattatta ttacgtgttg tctattatct gtttataggt 10620
tcactcgacg aactaaacta cctatacaag atatggttgt gccataattt ttataaattt 10680
tttttatgag tatttttaca aaaatgtata aagtgtatgt cttatgtata tttataaaaa 10740
tgctaaatat gcgatgtatc tatgttattt gtatttatct aaacaatacc tctacctcta 10800
gatattatac aaaaattttt tatttcggca tattaaagta aaatctagtt accttgaaaa 10860
tgaatacagt gggtggttcc gtatcaccag taagaacata atagtcgaat acagtatccg 10920
attgagattt tgcatacaat actagtctag aaagaaattt gtaatcatct tctgtgacgg 10980
gagtccatat atctgtatca tcgtcccatg ctatattcct gttatcatca ttagttaatg 11040
aaaataactc tcgtgcttca gaaaagtcaa atattgtatc catacataca tctccaaaac 11100
tatcgcttat acgtttatct ttaacgatac ctatacctag atggttattt actaacagac 11160
attttccaga tctattgact ataactccta tagtttccac atcaaccaag taatgatcat 11220
ctattgttat ataacaataa cataactctt ttccgttttt atcagtatgt atatctatat 11280
caacgtcgtc gttgtagtga atagtagtca ttgatctatt atatgaaacg gatatgtcta 11340
gaacggcaat tgttttacgt ccagttaaca ctttcgttga tttaaagtct agagtctttg 11400
caaacataat atccttatcc gactttatat ttcctgtagg gtggtataat tttattttgc 11460
ctccacatat cggtgtttcc aaatatatta ctagacaata ttccatatag ttattagtta 11520
agggtaccca attagaacac gtacgcttat tatcatcatt tggatcgtat ttcataaaag 11580
ttattgtact atcgatgtca acacattcta cattttttaa tcgtctatat agtatttttc 11640
tgatattttc tataatatca gaattgtctt ccatcggaag ttgtatacta tcggaatcag 11700
ttacatgttt aaataattct ctgatgtcat tccttataca atcaaattca ttattaaaca 11760
gtttaatagt ctgtagacct ttatcgtcgt aaatatccat tgtcttatta gttacgctta 11820
tttttatgtg tttttacgtt gctttattat attttataag aatgattgtt tgacgaatca 11880
cgagaactat taagacacat tattaggtat atattataaa aaagtttttg attacgatgt 11940
tataagagga aagaggacac attaacatca tacatcaatt aactacattc ttataacatc 12000
gtaatcaaaa gaattgcaat tttgatgtat aacaactgtc aatgggttat ggaattgtat 12060
attacatatt atacggtatg ttggtaacga caaataccga tcggtaattg tctgccggtg 12120
taatagaatt atatatatct atctattaca ccggccttgt atacataata ataagttgtg 12180
gtagtatgat ctccatattt ataatttagg actttgtatt cagttttttt ggaatcataa 12240
aaaataaaaa aaagttttac taatttaaaa ttatttacat ttttttcact gtttagtcgc 12300
ggatatggaa ttcgatcctg ccaaaatcaa tacatcatct atagatcatg taacaatatt 12360
acaatacata gatgaaccaa atgatataag actaacagta tgcattatca caaaaataaa 12420
tccacatttg gctaatcaat ttcgggcttg gaaaaaacgt atcgccggaa gggactatat 12480
gactaactta tctagagata caggaataca acaatcaaaa cttactgaaa ctgtcaaaaa 12540
aatagaaaca tatatggtct atatatacac tacaatttag ttattaattg gataaccgat 12600
gtgattatca atcaatatta agaaggttgg taaattggta catagctaat aatacctata 12660
cacccaataa tacaacaacc atttctgagt tggatatcat caaaatactg gataaatacg 12720
aggacgtgta tagagtaagt aaagaaaaag aatgtgaaat ttgctatgaa gttgtttact 12780
caaaacgata gatactttgg tttattggat tcgtgtaatc atatattttg cataacatgc 12840
atcaatatat ggcatagaac acgaagagaa accggtgcgt cggataattg tcctatatgt 12900
cgtacccgtt ttagaaacat aacaatgagc aagttaacta ataaataaaa agtttaattt 12960
gttgacgacg tatgtcgtta ttttttctcg tataaaagat taatttgatt ctaatataat 13020
ctttagtatt ggataaatat caattcaaat taattccatt agattatatc ataaataaaa 13080
atagtagcac gcactacttc agccaaatat tcttttttga aacgccatct atcgtagtga 13140
ggacacaagt gaacctataa tgagcaaatt tattagtatc ggttacatga aggactttac 13200
gtagagtggt gattccacta tctgtggtac gaacggtttc atcttctttg atgccatcac 13260
ccagatgttc tataaacttg gtatcctttg ccaaccaata catatagcta aactcaggca 13320
tatgttccac acatcctgaa caatgaaatt ctccagaaga tgttacaatg tctagatttg 13380
gacatttggt ttcaaccgcg ttaacatatg agtgaacaca cccatacatg aaagcgatga 13440
gaaataggat tttcatcttg ccaaaatatc actagaaaaa atttatttat caattttaaa 13500
ggtataaaaa atacttattg ttgctcgaat attttgtatt tgatggtata cggaagatta 13560
gaaatgtagg tattatcatc aactgattct atggttttat gtattctatc atgtttcact 13620
attgcgttgg aaataatatc atatgcttcc acatatattt tattttgttt taactcataa 13680
tactcacgta attctggatt attgacatat ctatgaataa ttttagctcc atgatcagta 13740
aatattaatg agaacatagt attaccacct accattattt ttttcatctc attcaattct 13800
taattgcaaa gatctatata atcattatag cgttgactta tggactctgg aatcttagac 13860
gatgtacagt catctataat catggcatat ttaatacatt gttttatagc atagtcgtta 13920
tctacgatgt tagatatttc tctcaatgaa tcaatcacac aatctaatgt aggtttatga 13980
cataatagca ttttcagcag ttcaatgttt ttagattcgt tgatggcaat ggctatacat 14040
gtatatccgt tatttgatct aatgttgaca tctgaaccgg attctagcag taaagatact 14100
agagattgtt tattatatct aacagccttg tgaagaagtg tttctcctcg tttgtcaatc 14160
atgttaatgt ctttaagata aggtaggcaa atgtttatag tactaagaat tgggcaagca 14220
taagacatgt cacaaagacc ctttttgtat gtataagtgt aaaaattata acattcatag 14280
ttggatttac ataggtgtcc aatcgggatc tctccatcat cgagataatt gatggcatct 14340
cccttccttt tttagtagat atttcatcgt gtaagaatca atattaatat ttctaaagta 14400
tccgtgtata gcctctttat ttaccacagt tccatattcc actagaggga tatcgccgaa 14460
tgtcatatac tcaattagta tatgttggag gacatccgag ttcattgttt tcaatatcaa 14520
aaagatggtt tccttatcat ttctccatag tggtacaata ctacacatta ttccgtgcgg 14580
ctttccattt tccaaaaaca atttgaccaa atctacatct ttattgtatc tataatcact 14640
atttagataa tcagccataa ttactcgagt gcaacatgtt agatcgtcta tatatgaata 14700
agccgtgtta tctattcctt tcattaacaa tttaacgatg tctatatcta tatgagatga 14760
cttaatataa tattgaagag ctgtacaata gtttttatct ataaaagacg gcttgattcc 14820
gtgattaatt agacatttaa caacttccgg acgcacatat gctctcgtat ccgactctga 14880
atacagatga gagatgatat acagatgcaa tacggtaccg caatttcgta gttgataatc 14940
atcatacgcg tatcagtact cgtcctcata aagaacactg cagccatttt ctatgaacaa 15000
atcaataatt tcaggaacag gatcatctgt cattacataa ttttctataa ctgaacgatg 15060
gttttcacat ttaacactca agtcaaatcc atgttctacc aacaccttta tcaagtcaac 15120
gtctacattt ttggatttca tatagctgaa tatattaaag tcatttatgt tgctaaatcc 15180
agtggcttct agtagagcca tcgctatatc ctttaacttt aacatgtcta ctatttgtgt 15240
attcttctaa tggggtagct gtctccaatt tttgcgtaat ggattagtgc cactgtctag 15300
tagtagtttg acgacctcga cattattaca atgctcatta aaaaggtatg cgtgtaaagc 15360
attattcttg aattggttcc tggtatcatt aggatctctg tctctcaaca tctgtttaag 15420
ttcatcgaga gccacctcct cattttccaa atagtcaaac attttgactg aatgagctac 15480
tgtgaactct atacacccac acaactaatg tcattaaata tcatgtcaaa aacttgtaca 15540
attattaata aaaataattt agtgtttaaa ttttaccagt tccagatttt acacctccgt 15600
taaccccact ttttacacca ctggacgatc ctcctcccca cattccaccg ccaccagatg 15660
tataagtttt agatccttta ttactaccat catgtccatg gataaagaca ctccacatgc 15720
cgccactacc ccctttagaa gacatattaa taagacttaa ggacaagttt aacaataaaa 15780
ttaatcacga gtaccctact accaacctac actattatat gattatagtt tctattttta 15840
cagtacctta actaaagtct ctagtcacaa gagcaatact accaacctac actattatat 15900
gattatagtt tctattttta taggaacgcg tacgagaaaa tcaaatgtct aatttctaac 15960
ggtagtgttg ataaacgatt atcgtcaatg gatacctcct ctatcatgtc gtctattttc 16020
ttactttgtt ctattaactt attagcatta tatattattt gattataaaa cttatattgc 16080
ttattagccc aatctgtaaa tatcggatta ttaacatatc gtttctttgt aggtttattt 16140
aacatgtaca tcactgtaag catgtccgta ccatttattt taatttgacg catatccgca 16200
atttcttttt cgcagtcggt tataaattct atatatgatg gatacatgct acatgtgtac 16260
ttataatcga ctaatatgaa gtacttgata catattttca gtaacgattt attattacca 16320
cctatgaata agtacctgtg atcgtctagg taatcaactg ttttcttaat acattcgatg 16380
gttggtaatt tactcagaat aatttccaat atcttaatat ataattctgc tatttctggg 16440
atatatttat ctgccagtat aacacaaata gtaatacatg taaacccata ttttgttatt 16500
atattaatgt ctgcgccatt atctattaac cattctacta ggctgacact atgcgactta 16560
atacaatgat aaagtatact acatccatgt ttatatcatc aatatacggc ttacaaagtt 16620
ttagtatcga taacacatcc aactcacgca tagagaaggt agggaataat ggcataatat 16680
ttattaggtt atcatcattg tcattatcta caactaagtt tccatttttt aaaatatact 16740
cgacaacttt aggatctcta ttgccaaatt tttgaaaata tttatttata tgcttaaatc 16800
tatataatgt agctccttca tcaatcatac atttaataac attgatgtat actgtatgat 16860
aagatacata ttctaacaat agatcttgta tagaatctgt atatctttta agaattgtgg 16920
atattattac gtaaactatt acacaattct aaaatataaa acgtatcacg gtcgaataat 16980
agttgatcaa ctatataatt atcgattttg tgatttttct tcctaaactg tttacgtaaa 17040
tagttagata gaatattcat tagttcatga ccactatagt tactatcgaa taacgcgtca 17100
aatatttccc gtttaatatc gcatttgtca agataataat agagtgtggt atgttcacga 17160
taagtataat aacgcatctc tttttcgtgt gaaattaaat agtttattac gtccaaagat 17220
gtagcataac catcttgtga cctagtaata atataataat agagaactgt tttacccatt 17280
ctatcatcat aatcagtggt gtagtcgtaa tcgtaattgt ctaattcatc atcccaatta 17340
taatattcac cagcacgtct aatctgttct attttgatct tgtatccata ctgtatgttg 17400
ctacatgtag gtattccttt atccaataat agtttaaaca catctacatt gggatttgat 17460
gttgtagcgt atttttctac aatattaata ccatttttga tactatttat ttctatacct 17520
ttcgaaatta gtaatttcaa taagtctata tcgatgttat cagaacatag atattcgagt 17580
atatcaaaat cattgatatt tttatagtcg actgacgaca ataacaaaat cacaacatcg 17640
tttttgatat tattattttt cttggtaacg tatgccttta atggagtttc accatcatac 17700
tcatataatg gatttgcacc actttctatc aatgattgtg cactgctggc atcgatgtta 17760
aatgttttac aactatcata gagtatctta tcgttaacca tgattggttg ttgatgctat 17820
cgcatttttt ggtttctttc atttcagtta tgtatggatt tagcacgttt gggaagcatg 17880
agctcatatg atttcagtac tgtagtgtca gtactattag tttcaataag atcaatctct 17940
agatctatag aatcaaaaca cgataggtca gaagataatg aatatctgta ggcttcttgt 18000
tgtactgtaa cttctcgttt tgttagatgt ttgcatcgtg ctttaacatc aatggtacaa 18060
attttatcct cgctttgtgt atcatattcg tccctactat aaaattgtat attcagatta 18120
tcatgagatg tgtatacgct aacggtatca ataaacggag cacaccattt agtcataacc 18180
gtaatccaaa aatttttaaa gtatatctta acgaaagaag ttgtgtcatt gtctacggtg 18240
tatggtacta gatcctcata agtgtatata tctagagtaa tgtttaattt atcaaatggt 18300
tgataatatg gatcctcatg acaatttccg aagatggaaa tgagatatag acatgcaata 18360
aatctaattg cggacatggt tactccttaa aaaaatacga ataatcacct tggctattta 18420
gtaagtgtca tttaacacta tactcatatt aatccatgga ctcataatct ctatacggga 18480
ttaacggatg ttctatatac ggggatgagt agttttcttc tttaacttta tactttttac 18540
taatcatatt tagactgatg tatgggtaat agtgtttaaa gagttcgttc tcatcatcag 18600
aataaatcaa tatctctgtt tttttgttat acagatgtat tacagcctca tatattacgt 18660
aatagaacgt gtcatctacc ttattaactt tcaccgcata gttgtttgca aatacggtta 18720
atcctttgac ctcgtcgatt tccgaccaat ctgggcgtat aatgaatcta aactttaatt 18780
tcttgtaatc attcgaaata atttttagtt tgcatccgta gttatcccct ttatgtaact 18840
gtaaatttct caacgcgata tctccattaa taatgatgtc gaattcgtgc tgtataccca 18900
tactgaatgg atgaacgaat accgacggcg ttaatagtaa tttacttttt catctttaca 18960
tattgggtac tagttttact atcataagtt tataaattcc acaagctact atggaataag 19020
ccaaccatct tagtataaca cacatgtctt aaagtttatt aattaattac atgttgtttt 19080
atatatcgct acgaatttaa acagagaaat cagtttagga aaaaaaaata tctatctaca 19140
tcatcacgtc tctgtattct acgatagagt gctactttaa gatgagacat atccgtgtca 19200
tcaaaaatat actccattaa aatgattatt ccggcagcga acttgatatt ggatatatca 19260
caacctttgt taatatctac gacaatagac agcagtccca tggttccata aacagtgagt 19320
ttatctttct ttgaagagat attttgtaga gatcttataa aactgtcgaa tgacatcgca 19380
tttatatctt tagctaaatc gtatatgtta ccatcgtaat atctaaccgc gtctatctta 19440
aacgtttcca tcgctttaaa gacgtttccg atagatggtc tcatttcatc agtcatactg 19500
agccaacaaa tataatcgtg tataacatct ttgatagaat cagactctaa agaaaacgaa 19560
tcggctttat tatacgcatt catgataaac ttaatgaaaa atgtttttcg ttgtttaagt 19620
tggatgaata gtatgtctta ataattgtta ttatttcatt aattaatatt tagtaacgag 19680
tacactctat aaaaacgaga atgacataac tagttatcaa agtgtctagg acgcgtaatt 19740
ttcatatggt atagatcctg taagcattgt ctgtattctg gagctatttt ctctatatct 19800
aatttctgaa cgttcaccaa tgtctctagc cactttggca ctaatagcga tcattcgctt 19860
agcgtcttct atattattaa ctggttgatt caatctatct agcaatggac cgtcggacag 19920
cgtcattctc atgttcttaa tcaatgtaca tacatcgccg tcatctacca attcatccaa 19980
caacataagc tttttaaaat catcattata ataggtttga tcgttgtcat ttctccaaag 20040
aatatatcta ataagtagag tcctcatgat tagttaacaa ctatttttta tgttaaatca 20100
attagtacac cgctatgttt aatacttatt catattttag tttttaggat tgagaatcaa 20160
tacaaaaatt aatgcatcat taattttaga aatacttagt ttccacgtag tcaatgaaac 20220
atttgaactc atcgtacagg acgttctcgt acaggacgta actataaacc ggtttatatt 20280
tgttcaagat agatacaaat ccgataactt tttttacgaa ttctacggga tccactttaa 20340
aagtgtcata ccgggttctt tttatttttt taaacagatt aatggtgtga tgttgattag 20400
gtcttttacg aatttgatat agaatagcgt ttacatattc tccataatgg tcaatcgcca 20460
tttgttcgta tgtcataaat tctttaatta tatgacactg tgtattattt agttcatcct 20520
tgttcatcat taggaatcta tccaatatgg caattatact agaactatag gtgcgttgta 20580
tacacatatt gatgtgtctg tttatacaat ccatgctact accttcgggt aaaattgtag 20640
catcatatac catttctagt actttaggtt cattgttatc cattgcagag gacgtcatga 20700
acgcatccta aaaaaatata ttatttttat gttattttgt taaaaataat catcgaatac 20760
gaatcatcca gtccactgaa tagcaaaatc tttactattt tggtatcttc caatgtggct 20820
gcctgatgta atggaaattc attctctaga agatttttca atgctccagc gttcaacaac 20880
gtacatacta gacgcacgtt attatcagct attgcataat acaaggcact atgtccatgg 20940
acatccgcct taaatgcatc tttgctagag agaaagcttt tcagctgctt agacttccaa 21000
gtattaattc gtgacagatc catgtctgaa acgagacgct aattagtgta taatttttgt 21060
catattgcac cagaattaat aatatctcta atagatctga ttagtagata catggctatc 21120
gcaaaacaac atatacacat ttaataaaaa taatatttat taagaaaatt cagatttcac 21180
gtacccatca atataaataa aataatgatt ccttacaccg tacccatatt aaggagattc 21240
taccttaccc ataaacaata taaatccagt aatatcatgt ctgatgatga acacaaatgg 21300
tgtattaaat tccagttttt caggagatga tctcgccgta gctaccataa tagtagatgc 21360
ctctgctaca gttccttgtt cgtcgacatc tatctttgca ttctgaaaca ttttataaat 21420
atataatggg tccctagtca tatgtttaaa cgacgcatta tctggattaa acatactagg 21480
agccatcatt tcggctatcg acttaatatc cctcttattt tcgatagaaa atttagggag 21540
tttaagattg tacactttat tccctaattg aaacgaccaa tagtctaatt ttgcagccgt 21600
aatagaatct gtgaaatggg tcatattatc acctattgcc aggtacatac taatattagc 21660
atccttatac ggaaggcgta ccatgtcata ttctttgtca tcgattgtga ttgtatttcc 21720
ttgcaattta gtaactacgt tcatcatggg aaccgttttc gtaccgtact tattagtaaa 21780
actagcattg cgtgttttag tgatatcaaa cggatattgc catatacctt taaaatatat 21840
agtattaatg attgcccata gagtattatt gtcgagcata ttagaatcta ctacattaga 21900
cataccggat ctacgttcta ctatagaatt aattttatta accgcatctc gtctaaagtt 21960
taatctatat aggccgaatc tatgatattg ttgataatac gacggtttaa tacacacagt 22020
attatctacg aaactttgat aagttagatc agtgtacgta tatttagatg ttttcagctt 22080
agctaatcct gatattaatt ctgtaaatgc tggacccaga tctctttttc tcaaatccat 22140
agtcttcaat aattctattc tagtattacc tgatgcaggc aatagcgaca taaacataga 22200
aaacgaataa ccaaacggtg agaagacaat attatcatct tgaatatttt tatacgctac 22260
tataccggca ttggtaaatc cttgtagacg ataggtagac gctgaacacg ttaacgatag 22320
tatcaataac gcaatcatga ttttatggta ttaataatta accttatttt tatgttcggt 22380
ataaaaatta ttgatgtcta cacatccttt tgtaattgac atctatatat ccttttgtat 22440
aatcaactct aatcacttta acttttacag ttttccctac cagtttatcc ctatattcaa 22500
catatctatc catatgcatc ttaacactct ctgccaagat agcttcagag tgaggatagt 22560
caaaaagata aatatataga gcataatcat tctcgtatac tctgcccttt attacatcgc 22620
ccgcattggg caacgaataa caaaatgcaa gcatcttgtt aacgggctcg taaattggga 22680
taaaaattat gtttttatat ctattttatt caagagaata ttcaggaatt tctttttccg 22740
gttgtatctc atcgcagtat atatcatttg tacattgttt catatttttt aatagtttac 22800
accttttagt aggactagta tcgtacaatt catagctgta ttttgaattc caatcacgca 22860
taaaaatatc ttctaattgt tgacgaagac ctaatccatc atccggtgta atattaatag 22920
atgctccaca tgtatccgta aagtaatttc ctgtccaatt tgaggtacct atataggccg 22980
ttttatcggt taccatatat ttggcatggt ttaccctaga atacggaatg ggaggatcag 23040
catctggtac aataaatagc tttacttcta tatttatgtt tttagatttt agcatagcga 23100
tagatcttaa aaagtttctc atgataaacg aagatcgttg ccagcaacta atcaatagct 23160
taacggatac ttgtctgtct atagcggatc ttcttaattc atcttctata taaggccaaa 23220
acaaaatttt acccgccttc gaataaataa tagggataaa gttcataaca gatacataaa 23280
cgaatttact cgcatttcta atacatgaca ataaagcggt taaatcattg gttctttcca 23340
tagtacatag ttgttgcggt gcagaagcaa taaatacaga gtgtggaaca ccacttacgt 23400
taatactaag aggatgatct gtattataat acgacggata aaagtttttc caattatatg 23460
gtagattgtt aactccaaga taccagtata cctcaaaaat ttgagtgaga tccgctgcca 23520
agttcctatt attgaagatc gcaataccca attctttgac ctgagttagt gatctccaat 23580
ccatgttagc gcttcctaaa taaatatgtg tattatcaga tatccaaaat tttgtatgaa 23640
gaactcctcc taggatattt gtaatatcta tgtatcgtac ttcaactccg gccatttgta 23700
gtctttcaac atcctttaat ggtttgttag atttattgac ggctactcta actcgtactc 23760
ctcttttggg taattgtaca atctcgttta atattatcgt gccgaaattc gtacccactt 23820
catccgataa actccaataa aaagatgata tatctagtgt ttttgtggta ttggatagaa 23880
tttccctcca catgttaaat gtagacaaat atactttatc aaattgcata cctataggaa 23940
tagtctctgt aatcactgcg attgtattat ccggattcat tttatttgtt aaaagaataa 24000
tcctatatca cttcactcta ttaaaaatcc aagtttctat ttctttcatg actgattttt 24060
taacttcatc cgtttcctta tgaagatgat gtttggcacc ttcataaatt tttatttctc 24120
tattacaatt tgcatgttgc atgaaataat atgcacctaa aacatcgcta atctcattgt 24180
ttgttccctg gagtatgaga gtcggggtgt taatcttgga aattattttt ctaaccttgt 24240
tggtagcctt caagacctga ctagcaaatc cagccttaat tttttcatga ttgattaatg 24300
ggtcgtattg gtatttataa actttatcca tatctctaga tactgattct ggacatagct 24360
ttccgactgg cgcatttggt gtgatggttc ccataagttt ggcagctagc agattcagtc 24420
ttgaaacagc atctgcatta actagaggag acattagaat cattgctgta aacaagtttg 24480
gattatcgta agaggctagt atagaaattg ttgctcccat ggaatgaccc aataagtaga 24540
tttaatagtt accacgtgct gtaccaaagt catcaatcat cattttttca ccattacttc 24600
ttccatgtcc aatatgatca tgtgagaata ctaaaattcc taacgatgat atgttttcag 24660
ctagttcgtc ataacgtcca gaatgtttac cagctccatg acttatgaat actaatgcct 24720
taggatatgt aatcattgtc cagattgaac atacagtttg cactcatgat tcacgttata 24780
taactatcaa tattaacagt tcgtttgatg atcatattat ttttatgttt tattgataat 24840
tgtaaaaaca tacaattaaa tcaatataga ggaaggagac ggctactgtc ttttgtgaga 24900
tagtcatggc gactaaatta gattatgagg atgctgtttt ttactttgtg gatgatgata 24960
aaatatgtag tcgcgactcc atcatcgatc taatagatga atatattacg tggagaaatc 25020
atgttatagt gtttaacaaa gatattacca gttgtggaag actgtacaag gaattgatga 25080
agttcgatga tgtcgctata cggtactatg gtattgataa aattaatgag attgtcgaag 25140
ctatgagcga aggagaccac tacatcaatt ttacaaaagt ccatgatcag gaaagtttat 25200
tcgctaccat aggaatatgt gctaaaatca ctgaacattg gggatacaaa aagatttcag 25260
aatctagatt ccaatcattg ggaaacatta cagatctgat gaccgacgat aatataaaca 25320
tcttgatact ttttctagaa aaaaaattga attgatgata taggggtctt cataacgcat 25380
aattattacg ttagcattct atatccgtgt taaaaaaaat tatcctatca tgtatttgag 25440
agttttatat gtagcaaaca tgatagctgt gatgccaata agctttagat attcacgcgt 25500
gctagtgtta gggatggtat tatctggtgg tgaaatgtcc gttatataat ctacaaaaca 25560
atcatcgcat atagtatgcg atagtagagt aaacattttt atagttttta ctggattcat 25620
acatcgtcta cccaattcgg ttatgaatga aattgtcgcc aatcttacac ccaacccctt 25680
gttatccatt agtatagtat taacttcgtt atttatgtca taaactgtaa atgattttgt 25740
agatgccata tcatacatga tattcatgtc cctattataa tcattactaa ctttatcaca 25800
atatatgttg ataatatcta tatatgatct agtctttgtg ggcaactgtc tatacaagtc 25860
gtctaaacgt tgtttactca tatagtatcg aacagccatc attacatggt cccgttccgt 25920
tgatagataa tcgagtatgt tagtggactt gtcaaatcta tataccatat tttctggaag 25980
tggatataca tagtcgtgat caacattatt gctagcctca tcttctatat cctgtactat 26040
accatctaca taatctacga tattattaca cataaacatc gacaacatac tattgtttat 26100
tatctaagtc ctgttgatcc aaacccttga tctcctctat ttgtactatc tagagattgt 26160
acttcttcca gttctggata atatatacgt tgatagatta gctgagctat tctatctcca 26220
gtatttacat taaacgtaca ttttccatta ttaataagaa tgactcctat gtttccccta 26280
taatcttcgt ctattacacc acctcctata tcaatgcctt ttagtgacag accagaccta 26340
ggagctattc taccatagca aatcttaggc atggacatac taatatctgt cttaattaac 26400
tgtctttctc ctggagggat agtataatcg taagcgctat acaaatcata tccggcagca 26460
cccggcgatt gcctagtagg agatttagct ctgttagttt ccttaacaaa tctaactggt 26520
gagttaatat tcatgttgaa cataaaacta atattttatt tcaaaattat ttaccatccc 26580
atatattcca tgaataagtg tgatgattgt acacttctat agtatctata tacgattcac 26640
gataaaatcc tcctatcaat agcagtttat tatccactat gatcaattct ggattatccc 26700
tcggataaat aggatcatct atcagagtcc atgtattgct ggattcacaa taaaattccg 26760
catttctacc aaccaagaat aaccttctac cgaacactaa cgcgcatgat ttataatgag 26820
gataataagt ggatggtcca aactgccact gatcatgatt gggtagcaaa tattctgtag 26880
ttgtatcagt ttcagaatgt cctcccatta cgtatataac attgtttatg gatgccactg 26940
ctggattaca tctaggtttc agaagactcg gcatattaac ccaagcagca tccccgtgga 27000
accaacgctc aacagatgtg ggatttggta gacctcctac tacgtataat ttattgttag 27060
cgggtatccc gctagcatac agtctggggc tattcatcgg aggaattgga atccaattgt 27120
ttgatatata atttacagct atagcattgt tatgtatttc attgttcatc catccaccga 27180
tgagatatac tacttctcca acatgagtac ttgtacacat atggaatata tctataattt 27240
gatccatgtt cataggatac tctatgaatg gatacttgta tgatttgcgt ggttgtttat 27300
cacaatgaaa tattttggta cagtctagta tccattttac attatttata cctctgggag 27360
aaagataatt tgacctgatt acatttttga taaggagtag cagatttcct aatttatttc 27420
ttcgctttat ataccactta atgacaaaat cctcatctgg aacatttagt tcatcgcttt 27480
ctagaataag tttcatagat agataatcaa aattgtctat gatgtcatct tccagttcca 27540
aaaagtgttt ggcaataaag tttttagtat gacataagag attggatagt ccgtattcta 27600
tacccatcat gtaacactcg acacaatatt cctttctaaa atctcgtagg ataaagttta 27660
tacaagtgta gatgataaat tctacagagg ttaatataga agcacgtaat aaattgacga 27720
cgttatgact atctatatat acctttccag tatatgagta aataactata gaagttagac 27780
tgtgaatgtc aaggtctaga caaaccctcg taactggatc tttatttttc gtgtattttt 27840
gacgtaaatg tgtgcgaaag taaggagata actttttcaa tatcgtagaa ttgactatta 27900
tattgcctcc tatggcatca ataattgttt tgaatttctt agtcatagac aatgctaata 27960
tattcttaca gtacacagta ttgacaaata tcggcattta tgtttcttta aaagtcaaca 28020
tctaaagaaa aatgattatc ttcttgagac ataactccca ttttttggta ttcacccaca 28080
cgtttttcga aaaaattagt tttaccttct aatgatatat tttccatgaa atcaaacgga 28140
ttggtaacat tataaatttt tttaaatccc aattcagaaa tcaatctatc cgcgacgaat 28200
tctatatatg ttttcatcat ttcacaattc attcctataa gtttaactgg aagagccgca 28260
gtaagaaatt cttgttcaat ggataccgca tctgttataa tagatctaac ggtttcttca 28320
ctcggtggat gcaataaatg tttaaacatc aaacatgcga agtcgcagtg tagaccctcg 28380
tctctactaa tcaattcgtt ggaaaacgtg agtccgggca ttaggccacg ctttttaagc 28440
caaaatatgg aagcgaatga tccggaaaag aagattcctt ctactgcagc aaaggcaata 28500
agtctctctc cataaccggc gctgtcatgt atccactttt gagcccaatc ggccttcttt 28560
tttacacaag gcatcgtttc tatggcatta aagagatagt ttttttcatt actatcttta 28620
acataagtat cgatcaaaag actatacatt tccgaatgaa tgttttcaat ggccatctga 28680
aatccgtaga aacatctagc ctcggtaatc tgtacttctg tacaaaatcg ttccgccaaa 28740
ttttcattca ctattccgtc actggctgca aaaaacgcca atacatgttt tataaaatat 28800
ttttcgtctg gtgttagttt attccaatca ttgatatctt tagatatatc tacttcttcc 28860
actgtccaaa atgatgcctc tgccttttta tacatgttcc agatgtcatg atattggatt 28920
gggaaaataa caaatctatt tggatttggt gcaaggatgg gttccataac taaattaaca 28980
ataacaataa attttttttc agttatctat atgcctgtac ttggatcttt tgtacatcga 29040
tatcgccgca atcactacaa taattacaag tattattgat agcattgtta ttagtactat 29100
cataattaaa ttatcgttat tatcattttg taattgtgac atcatactag ataaatcgtt 29160
tgcgagattg ttgtgggaag cgggcatgga ggatgaatta tcgttattat tatttaaagc 29220
ctcccattcg gattcacaaa tatggcgcgc gttcaacatt ttatggaaac agataacaag 29280
aaaactcgtc atcgttcaaa tttttaacga tagtaaaccg attaaacgtc gagctaattt 29340
ctaacgctag cgactctgtt ggatatgggt ttccagatat atatcttttc agttccccta 29400
cgtatctata atcatctgta ggaaatggaa gatatttcca tttatctact gttcctaata 29460
tcatatgtgg tggtgtagta gaaccattaa gcgcgaaaga tgttatttcg catcgtattt 29520
taacttcgca ataatttctg gttagataac gcactctacc agtcaagtca atgatattag 29580
cctttacaga tatattcata gtagtcgtaa cgatgactcc atcttttaga tgcgatactc 29640
ctttgtatgt accagaatct tcgtacctca aactcgatat atttaaacaa gttaatgaga 29700
tattaacgcg ttttatgaat gatgatatat aaccagaagt tttatcctcg gtggctagcg 29760
ctataacctt atcattataa taccaactag tgtgattaat atgtgacacg ttagtgtggg 29820
tacaaatatg tacattatcg tctacgtcgt attcgataca tccgcataca gccaacaaat 29880
ataaaatgac aaatactcta acgccgttcg tacccatctt gatgcggttt aataaatgtt 29940
ttgatttcaa tttattgtaa aaaaagattc ggttttatac tgttcgatat tctcattgct 30000
tatattttca tctatcatct ccacacagtc aaatccgtgg ttagcatgca cctcatcaac 30060
cggtaaaaga ctatcggact cttctatcat tataactcta gaatatttaa tttggtcatt 30120
attaatcaag tcaattatct tatttttaac aaacgtgagt attttactca ttttttataa 30180
aaacttttag aaatatacag actctatcgt gtgtctatat cttcttttta tatccaatgt 30240
atttatgtct gatttttctt catttatcat atataatggt ccaaattcta cacgtgcttc 30300
ggattcatcc agatcattaa ggttcttata attgtaacat ccttctcttc cctcttctac 30360
atcttccttc ttattcttat tcttagcgtc acagaatcta ccacagcagg atcccatgac 30420
gagcgtcata ttaaactaat ccattttcaa ttataatata cgattagtaa tgaccattaa 30480
aataaaaata ttcttcataa ccggcaagaa agtgaaaagt tcacattgaa actatgtcag 30540
tagtatacat catgaaatga tgatatatat atactctatt ttggtggagg attatatgat 30600
ataattcgtg gataatcatt cttaagacac atttcttcat tcgtaaatct tttcacgtta 30660
aatgagtgtc catattttgc aatttcttca tatgatggcg gtgtacgtgg acgaggctgc 30720
tcctgttctt gttgtagtcg ccgactgtcg tgtctgcgtt tagatccctc cattatcgcg 30780
attgcgtaga tggagtacta ttttatacct tgtaattaaa tttttttatt aattaaacgt 30840
ataaaaacgt tccgtatctg tatttaagag ccagatttcg tctaatagaa caaatagcta 30900
cagtaaaaat aactagaata attgctacac ccactagaaa ccacggatcg taatacggca 30960
atcggttttc gataataggt ggaacgtata ttttatttaa ggacttaaca attgtctgta 31020
aaccacaatt tgcttccgcg gatcctgtat taactatctg taaaagcata tgttgaccgg 31080
gcggagccga acattctccg atatccaatt tctgtatatc tataatatta ttaacctccg 31140
catacgcatt acagttcttt tctagcttgg ataccgcact aggtacatcg tctagatcta 31200
ttcctatttc ctcagcgata gctcttctat ccttttccgg aagcaatgaa atcacttcaa 31260
taaatgattc aaccatgagt gtgaaactaa gtcgagaatt actcatgcat ttgttagtta 31320
ttcggagcgc gcaattttta aactgtccta taacctctcc tatatgaata gcacaagtga 31380
cattagtagg gatagaatgt tgagctaatt tttgtaaata actatctata aaaagattat 31440
acaaagtttt aaactcttta gtttccgcca tttatccagt ctgagaaaat gtctctcata 31500
ataaattttt ccaagaaact aattgggtga agaatggaaa cctttaatct atatttatca 31560
cagtctgttt tggtacacat gatgaattct tccaatgccg tactaaattc gatatctttt 31620
tcgatttctg gatatgtttt taataaagta tgaacaaaga aatggaaatc gtaataccag 31680
ttatgtttaa ctttgaaatt gttttttatt ttcttgttaa tgattccagc cacttgggaa 31740
aagtcaaagt cgtttaatgc cgatttaata cgttcattaa aaacaaactt tttatccttt 31800
agatgaatta ttattggttc attggaatca aaaagtaaga tattatcggg tttaagatct 31860
gcgtgtaaaa agttgtcgca gcatggtagt tcgtaaattt taatgtataa cagagccatc 31920
tgtaaaaaga taaactttat gtattgtacc aaagatttaa atcctaattt gatagctagc 31980
tcggtatcta ctttatctgc cgaatacagt gctaggggaa aaattataat atttcctctt 32040
tcgtattcgt agttagttct cttttcatgt tcgaaaaagt gaaacatgcg gttaaaatag 32100
tttataacat taatattact gttaataact gccggataaa agtgggatag taatttcacg 32160
aatttgatac tgtcctttct ctcgttaaac gcctttaaaa aaactttaga agaatatctc 32220
aatgatagtt cctgaccatc catagtttgt atcaataata gcaacatatg aagaacacgt 32280
ttatacagag tatgtaaaaa tgttaattta tagtttaatc ccatggccca cgcacacacg 32340
attaattttt tttcatctcc ctttagattg ttgtatagaa atttgggtac tgtgaactcc 32400
gccgtagttt ccatgggact atataatttt gtggcctcga atacaaattt tactacatag 32460
ttatctatct taaagactat accatatcct cctgtagata tgtgataaaa atcgtcgttt 32520
ataggataaa atcgtttatc cttttgttgg aaaaaggatg aattaatgta atcattctct 32580
tctatcttta gtagtgtttc cttattaaaa ttcttaaaat aatttaacaa tctaactgat 32640
ggagcccaat tttggtgtaa atctaattgg gacattatat tgttaaaata caaacagtct 32700
cctaatataa cagtatctga taatctatgg ggagacatcc attgatattc aggggatgaa 32760
tcattggcaa cacccattta ttgtacaaaa agccccaatt tacaaacgaa agtccaggtt 32820
tgatagagac aaactattaa ctattttgtc tctgttttta atttctttgg taatgaaatt 32880
attcacaata tcagtatctt ctttatctac cagagatttt actaacttga taaccttggc 32940
tgtctcattc aatagggtag taatatttgt atgtgtgata ttgatatctt ttagaagtga 33000
ttctttgatg gtgccagcat acgaattaca ataatgcaga aactcggtta acatgcagga 33060
attatagtaa gccaattcca attgttgcct gtgttgtatt agagtgtcaa tatgagcaat 33120
ggtgtccttg cgtttctctg atagaatgcg agcagcgatt ttggcgttat catttgacga 33180
tatttctgga atgacgaatc ctgtttctac taactttttg gtaggacaaa gtgaaacaat 33240
caagaagata gcttctcctc ctatttgtgg aagaaattga actcctctag atgatctcct 33300
tgacagatat tggaccgaat tacagaagta cctggaatgt aaagccctga aaccccctca 33360
ttttttaagc agattgttgc cgtaaatcct gcactatgcc caagatagag agctcctttg 33420
gtgaatccat ctctatgttt cagtttaacc aagaaacagt cagctggtct aaaatttcca 33480
tctctatcta atacagcatc taacttgatg tcaggaacta tgaccggtta tgttatatgt 33540
aacattgagt aaatccttaa gttcataatc atcactgtca tcagttatgt acgatccaaa 33600
caatgtttct actggcatag tggatacgaa gatgctatcc atcagaatgt ttccctgatt 33660
agtattttct atatagctat tcttctttaa acgattttcc aaatcagtaa ctatgttcat 33720
ttttttagga gtaggacgcc tagccagtat ggaagaggat tttctagatc ctctcttcaa 33780
catctttgat ctcaatggaa tgcaaaaccc catagtgtaa caaccaacga taaaaataat 33840
attgtttttc actttttata attttaccat ctgactcatg gattcattaa tatctttata 33900
agagctacta acgtataatt ctttataact gaactgagat atatacaccg gatctatggt 33960
ttccataatt gagtaaatga atgctcggca ataactaatg gcaaatgtat aaaacaacga 34020
aattatacta gagttgttaa agttaatatt ttctatgagc tgttccaata aattatttgt 34080
tgtaactgcg ttcaagtcat aaatcatctt gatactatcc agtaaaccgt ttttaagttc 34140
tggaatatta ttatcccatt gtaaagcccc taattcgact atcgaatatc ctgctctgat 34200
agcagtttca atatcgacgg acgtcaatac tgtaataaag gtggtagtat tgtcatcatc 34260
gtgataaact actggaatat ggtcgttagt aggtacggta actttacaca acgcgatata 34320
taactttcct tttgtaccat ttttaacgta gttgggacgt cctgcagggt attgttttga 34380
agaaatgata tcgagaacag atttgatacg atatttgttg gattcctgat tatttactat 34440
aatataatct agacagatag atgattcgat aaatagagaa ggtatatcgt tggtaggata 34500
atacatcccc attccagtat tctcggatac tctattaatg acactagtta agaacatgtc 34560
ttctattcta gaaaacgaaa acatcctaca tggactcatt aaaacttcta acgctcctga 34620
ttgtgtctcg aatgcctcgt acaaggattt caaggatgcc atagattctt tgaccaacga 34680
tttagaattg cgtttagcat ctgatttttt tattaaatcg aatggtcggc tctctggttt 34740
gctaccccaa tgataacaat agtcttgtaa agataaaccg caagaaaatt tatacgcatc 34800
catccaaata accctagcac catcggatga tattaatgta ttattataga ttttccatcc 34860
acagttattg ggccagtata ctgttagcaa cggtatatcg aatagattac tcatgtaacc 34920
tactagaatg atagttcgtg tactagtcat aatatcttta atccaatcta agaaatttaa 34980
aattagattt tttacactgt taaagttaac aaaggtatta cccggatacg tggatatcat 35040
atatggtatt ggtccattat cagtaatagc tccataaact gatacggcga tggtttttat 35100
atgtgtttga tctaacgagg aagaaattcg cgcccacaat tcatctctag atatgtattt 35160
aatatcaaac ggtaacacat caatttcggg acgcgtatat gtttctaaat ttttaatcca 35220
aatataatga tgacctatat gccctattat catactgtca actatagtac acctagagaa 35280
cttacgatac atctgtttcc tataatcgtt aaattttaca aatctataac atgctaaacc 35340
ttttgacgac aaccattcat taatttctga tatggaatct gtattctcaa taccgtatcg 35400
ttctaaagcc agtgctatat ctccctgttc gtgagaacgc tttcgtataa tatcgatcaa 35460
cggataatct gaagtttttg gagaataata tgactcatga tctatttcgt ccataaacaa 35520
tctagacata ggaattggag gcgatgatct taattttgtg caatgagtcg tcaatcctat 35580
aacttctaat attgtaatat tcatcatcga cataacacta tctatgttat catcgtatat 35640
tagtatacca tgaccttctt catttcgtgc caaaatgata tacagtctta aatagttacg 35700
caatatctca atagtttcat aattgttagc tgttttcatc aaggtttgta tcctgtttaa 35760
catgatggcg ttctatacgt ttctattttt taaattttta acgatttact gtggctagat 35820
acccaatctc tctcaaatat ttttttagcc tcgcttacaa gctgtttatc tatactatta 35880
aaactgacga atccgtgatt ttggtaatgg gttccgtcga aatttgccga agtgatatga 35940
acatattcgt cgtcgactat caacaatttt gtattattct gaatagtgaa aaccttcaca 36000
gatagatcat tttgaacaca caacgcgtct agacttctgg cggttgccat agaatatacg 36060
tcgttcttat cccaattacc aactagaagt ctgatcttaa ctcctctatt aatggctgct 36120
tctataatgg agttgtaaat gtcgggccaa tagtagctat taccgtcgac acgtgtagtg 36180
ggaactatgg ccaaatgttc aatatctata ctagtcttag ccgacttgag tttatcaata 36240
actacatcag tgtctagatc tctagaatat cccaataggt gttccggaga atcagtaaag 36300
aacactccac ctataggatt cttaatatga tacgcagtgc taactggcag acaacaagcc 36360
gcagagcata aattcaacca tgaatttttt gcgctattaa aggctttaaa agtatcaaat 36420
cttctacgaa gatctgtggc cagcggggga taatcagaat atacacctaa cgttttaatc 36480
gtatgtatag atcctccagt aaatgacgcg tttcctacat aacatctttc attatctgac 36540
acccaaaaac aaccgagtag tagtcccaca ttattttttt tatctatatt aacggttata 36600
aaatttatat ccgggcagtg actttgtagc tctcccagat ttcttttccc tcgttcatct 36660
agcaaaacta ttattttaat ccctttttca gatgcctctt ttagtttatc aaaaataagc 36720
gctcccctag tcgtactcag aggattacaa caaaaagatg ctatgtatat atatttctta 36780
gctagagtga taatttcgtt aaaacattca aatgttgtta aatgatcgga tctaaaatcc 36840
atattttctg gtagtgtttc taccagccta cattttgctc ccgcaggtac cggtgcaaat 36900
ggccacattt agttaacata aaaacttata catcctgttc tatcaacgat tctagaatat 36960
catcggctat atcgctaaaa ttttcatcaa agtcgacatc acaacctaac tcagtcaata 37020
tattaagaag ttccatgatg tcatcttcgt ctatttctat atccgtatcc attgtagatt 37080
gttgaccgat tatcgagttt aaatcattac taatactcaa tccttcagaa tacaatctgt 37140
gtttcattgt aaatttatag gcggtgtatt taagttggta gattttcaat tatgtatcaa 37200
tatagcaaca gtagttcttg ctcctccttg attctagcat cctcttcatt attttcttct 37260
acgtacataa acatgtccaa tacgttagac aacacaccga cgatggcggc cgccacagac 37320
acgaatatga ctaaaccgat gaccatttaa aaacccctct ctagctttca cttaaactgt 37380
atcgattatt cttttagaac atgtataata taaaaacatt attctatttc gaatttaggc 37440
ttccaaaaat ttttcatccg taaaccgata ataatatata tagacttgtt aatagtcgga 37500
ataaatagat taatgcttaa actatcatca tctccacgat tagagataca atatttacat 37560
tttttttgct gtttcgaaac tttatcaata cacgttaata caaacccagg aaggagatat 37620
tgaaactgag gctgttgaaa atgaaacggt gaatacaata attcagataa tgtaaaatca 37680
tgattccgta ttctgatgat attagaactg ctaatggatg tcgatggtat gtatctagga 37740
gtatctattt taacaaagca tcgatttgct aatatacaat tatcattttg attaattgtt 37800
attttattca tattcttaaa aggtttcata tttatcaatt cttctacatt aaaaatttcc 37860
atttttaatt tatgtagccc cgcaatactc ctcattacgt ttcatttttt gtctataata 37920
tccattttgt tcatctcggt acatagatta tccaattgag aagcgcattt agtagttttg 37980
tacattttaa gtttattgac gaatcgtcga aaactagtta tagttaacat tttattattt 38040
gataccctga tattaatacc cctgccgtta ctattattta taactgatgt aatccacgta 38100
acattggaat taactatcga tagtaatgca tcgacgcttc caaaattgtc tattataaac 38160
tcaccgataa tttttttatt acatgttttc atattcatta ggattattaa atctttaatc 38220
ttactacgat tgtatgcgtt gatattgcaa gacgtcattc taaaagacgg aggatctcca 38280
tcaaatgcca gacaatcacg tacaaagtac atggaaatag gttttgttct attgcgcatc 38340
atagatttat atagaacacc cgtagaaata ctaatttgtt ttactctata aaatactaat 38400
gcatctattt catcgttttg tataacgtct ttccaagtgt caaattccaa atttttttca 38460
ttgatagtac caaattcttc tatctcttta actacttgca tagataggta attacagtga 38520
tgcctacatg ccgttttttg aaactgaata gatgcgtcta gaagcgatgc tacgctagtc 38580
acaatcacca ctttcatatt tagaatatat atatgtaaaa atatagtaga atttcatttt 38640
gttttttttc tatgctataa atgaattctc attttgcatc tgctcatact ccgttttata 38700
tcaataccaa agaaggaaga tatctggttc taaaagccgt taaagtatgc gatgttagaa 38760
ctgtagaatg cgaaggaagt aaagcttcct gcgtactcaa agtagataaa ccctcatcac 38820
ccgcgtgtga gagaagacct tcgtcccctt ccagatgcga gagaatgaat aacccaggaa 38880
aacaagttcc gtttatgagg acggacatgc tacaaaatat gttcgcggct aatcgcgata 38940
atgtagcttc tagacttttg tcctaaaata caattatatc cttttcgata ttaataaatc 39000
cgtgtcgtcc aggtttttta tctctttcag tatgtgaata gataggtatt ttatctctat 39060
tcatcatcga atttaagaga tccgataaac attgtttgta ttctccagat gtcagcatct 39120
gatacaacaa tatatgtgca cataaacctc tggcacttat ttcatgtacc ttccccttat 39180
cactaaggag aatagtattt gagaaatatg tatacatgat attatcatga attagatata 39240
cagaatttgt aacactctcg aaatcacacg atgtgtcggc gttaagatct aatatatcac 39300
tcgataacac attttcatct agatacacta gacatttttt aaagctaaaa tagtctttag 39360
tagtaacagt aactatgcga ttattttcat cgatgataca tttcatcggc atattattac 39420
gcttaccatc aaagactata ccatgtgtat atctaacgta ttctagcatg gttgccatac 39480
gcgcattaaa cttttcagga tctttggata gatcttccaa tctatctatt tgagaaaaca 39540
tttttatcat gttcaatagt tgaaacgtcg gatccactat atagatatta tctataaaga 39600
ttttaggaac tacgttcatg gtatcctggc gaatattaaa actatcaatg atatgattat 39660
cgttttcatc ttttatcacc atatagtttc taagatatgg gattttactt aatataatat 39720
tatttcccgt aataaatttt attagaaatg ccaaatctat aagaaaagtc ctcgaattag 39780
tttgaagaat atctatatcg ccgtaccgta tatttggatt aattagatat agagaatatg 39840
atccgtaaca tatacaactt ttattatggc gtctaagata ttcttccatc aacttattaa 39900
catttttgac tagggaagat acattatgac gtcccattac ttttgccttg tctattactg 39960
cgacgttcat agaatttagc atatctcttg ccaattcttc cattgatgtt acattataag 40020
aaattttaga tgaaattaca tttggagctt taatagtaag aactcctaat atgtccgtgt 40080
atgtggtcac taatacagat tgtagttcta taatcgtaaa taatttacct atattatatg 40140
tttgagtctg tttagaaaag tagctaagta tacgatcttt tatttctgat gcagatgtat 40200
caacatcgga aaaaaatctt tttttattct tttttactaa agatacaaat atgtctttgt 40260
taaaaacagt tattttctga atatttctag cttgtaattt taacatatga tattcgttca 40320
cactaggtac tctgcctaaa taggtttcta taatctttaa tgtaatatta ggaaaagtat 40380
tctgatcagg attcctattc attttgagga tttaaaactc tgattattgt ctaatatggt 40440
ctcaacacaa actttttcac agagcgatag agtttttgat aactcgtttt tcttaagaaa 40500
tataaaacta ctgtctccag agctcgctct atcttttatt ttatttaatt cgatacaaac 40560
tcctgatact ggttcagaaa gtaattcatt aattttcagt cctttataga agatatttaa 40620
tatagataat acaaaatctt cagtttttga tatcgatctg attgatccta gaactagata 40680
tattaataac gtgctcatta ggcagtttat ggcagcttga taattagata tagtatattc 40740
cagttcatat ttattagata ccgcattgcc cagattttga tattctatga attcctctga 40800
aaataaatcc aaaataacta gacattctat tttttgtgga ttagtgtact ctcttccctc 40860
tatcatgttc actactggtg tccacgatga taaatatcta gagggaatat aatatagtcc 40920
ataggatgcc aatctagcaa tgtcgaataa ctgtaatttt attcttcgct cttcattatg 40980
aattgattct tgaggtataa acctaacaca aattatatta ttagactttt cgtatgtaat 41040
gtctttcatg ttataagttt ttaatcctgg aatagaatct attttaatga ggcttttaaa 41100
cgcagagttc tccaacgagt caaagcataa tactctgttg gttttcttat atacgatgtt 41160
acgattttct tctttgaatg gaataggttt ttgaattagt ttataattac aacataatag 41220
ataaggaagt gtgcaaatag tacgcggaaa aaacataata gctcccctgt tttcatccat 41280
ggttttaagt aaatgatcac tggcttcttt agtcaatgga tattcgaaca ttaaccgttt 41340
catcatcatt ggacagaatc catatttctt aatgtaaaga gtgatcaaat cattgtgttt 41400
attgtaccat cttgttgtaa atgtgtattc ggttatcgga tctgctcctt tttctattaa 41460
agtatcgatg tcgatctcgt ctaagaattc aactatatcg acatatttca tttgtataca 41520
cataaccatt actaacgtag aatgtatagg aagagatgta acgggaacag ggtttgttga 41580
ttcgcaaact attctaatac ataattcttc tgttaatacg tcttgcacgt aatctattat 41640
agatgccaag atatctatat aattattttg taagatgatg ttaactatgt gatctatata 41700
agtagtgtaa taattcatgt atttcgatat atgttccaac tctgtctttg tgatgtctag 41760
tttcgtaata tctatagcat cctcaaaaaa tatattcgca tatattccca agtcttcagt 41820
tctatcttct aaaaaatctt caacgtatgg aatataataa tctattttac ctcttctgat 41880
atcattaatg atatagtttt tgacactatc ttctgtcaat tgattcttat tcactatatc 41940
taagaaacgg atagcgtccc taggacgaac tactgccatt aatatctcta ttatagcttc 42000
tggacataat tcatctatta taccagaatt aatgggaact attccgtatc tatctaacat 42060
agttttaaga aagtcagaat ctaagacctg atgttcatat attggttcat acatgaaatg 42120
atctctattg atgatagtga ctatttcatt ctctgaaaat tggtaactca ttctatatat 42180
gctttccttg ttgatgaagg atagaatata ctcaatagaa tttgtaccaa caaactgttc 42240
tcttatgaat cgtatatcat catctgaaat aatcatgtaa ggcatacatt taacaattag 42300
agacttgtct cctgttatca atatactatt cttgtgataa tttatgtgtg aggcaaattt 42360
gtccacgttc tttaattttg ttatagtaga tatcaaatcc aatggagcta cagttcttgg 42420
cttaaacaga tatagttttt ctggaacgaa ttctacaaca ttattataaa ggactttggg 42480
tagataagtg ggatgaaatc ctattttaat taatgcgata gccttgtcct cgtgcagata 42540
tccaaacgct tttgtgatag tatggcattc attgtctaga aacgctctac gaatatctgt 42600
gacagatatc atctttagag aatatactag tcgcgttaat agtactacaa tttgtatttt 42660
ttaatctatc tcaataaaaa aattaatatg tatgattcaa tgtataacta aactactaac 42720
tgttattgat aactagaatc agaatctaat gatgacgtaa ccaagaagtt tatctactgc 42780
caatttagct gcattatttt tagcatctcg tttagatttt ccatctgcct tatcgaatac 42840
tcttccgtcg atatctacac aggcataaaa tgtaggagag ttactaggcc ccactgattc 42900
aatacgaaaa gaccaatctc tcttagttat ttggcagtac tcattaataa tggtgacagg 42960
gttagcatct ttccaatcaa taattttttt agccggaata acatcatcaa aagacttatg 43020
atcctctctc attgattttt cgcgggatac atcatctatt atggcgtcag ccataacatc 43080
agcatccggc ttatccgcct ccgttgtcat aaaccaacga ggaggaatat cgtcggagct 43140
gtacaccata gcactacgtt gaagatcgta cagagcttta ttaacttctc gcttctccat 43200
attaagttgt ctagttagtt gtgcagcagt agctccttcg attccaatgt ttttaatagc 43260
cgcacacaca atctctgcgt cagaacgctc gtcaatatag atcttagaca tttttagaga 43320
gaactaacac aaccagcaat aaaactaatt tattttatca tttttttatt catcatcctc 43380
tggtggttcg tcgtttctat cgaatgtgga tctgattaac ccgtcatcta taggtgatgc 43440
tggttctgga gattctggag gagatggatt attatctgga agaatctctg ttatttcctt 43500
gttttcatgt atcgattgcg ttgtaacatt aagattgcga aatgctctaa atttgggagg 43560
cttaaagtgt tgtttgcaat ctctacacgc atgtctaact agtggaggtt cgtcagcggc 43620
tctagtttga atcatcatcg gcgtagtatt cctactttta cagttaggac acggtgtatt 43680
gtatttctcg tcgagaacgt taaaataatc gttgtaactc acatccttta ttttatctat 43740
attgtattct actcctttct taatgcattt tataccgaat aagagatagc gaaggaattc 43800
tttttcggtg ccgctagtac ccttaatcat atcacatagt gttttatatt ccaaatttgt 43860
ggcaatagac ggtttatttc tatacgatag tttgtttctg gaatcctttg agtattctat 43920
accaatatta ttctttgatt cgaatttagt ttcttcgata ttagattttg tattacctat 43980
attcttgatg tagtactttg atgatttttc catggcccat tctattaagt cttccaagtt 44040
ggcatcatcc acatattgtg atagtaattc tcggatatca gtagcggcta ccgccattga 44100
tgtttgttca ttggatgagt aactactaat gtatacattt tccatttata acacttatgt 44160
attaactttg ttcatttata ttttttcatt attatgttga tattaacaaa agtgaatata 44220
tatgttaata attgtattgt ggttatacgg ctacaatttc ataatgagtg gaagtcagtg 44280
tccgatgatc aatgacgata gctttactct gaaaagaaag tatcaaatcg atagtgcgga 44340
gtcaacaata aaaatggata agaagaggat aaagtttcag aatagagcca aaatggtaaa 44400
agaaataaat cagacaataa gagcagcaca aactcattac gagacattga aactaggata 44460
cataaaattt aagagaatga ttaggactac tactctagaa gatatagcac catctattcc 44520
aaataatcag aaaacttata aactattctc ggacatttca gccatcggca aagcatcaca 44580
gaatccgagt aagatggtat atgctctgct gctttacatg tttcccaatt tgtttggaga 44640
tgatcataga ttcattcgtt atagaatgca tccaatgagt aaaatcaaac acaagatctt 44700
ctctcctttc aaacttaatc ttattagaat attagtggaa gaaagattct ataataatga 44760
atgcagatct aataaatgga gaataattgg aacacaagtt gataaaatgt tgatagctga 44820
atctgataaa tatacaatag atgcaaggta taacctaaaa cccatgtata gaatcaaggg 44880
aaaatctgaa gaagataccc tctttatcaa acagatggta gaacaatgtg tgacatccca 44940
ggaattggtg gaaaaagtgt tgaagatact gtttagagat ttgttcaaga gtggagaata 45000
caaagcgtac agatacgatg atgatgtaga aaatggattt attggattgg atacactaaa 45060
attaaacatt gttcatgata tagttgaacc atgtatgcct gttcgtaggc cagtggctaa 45120
gatactgtgt aaagaaatgg taaataaata ctttgagaat ccgctacata ttattggtaa 45180
aaatcttcaa gagtgcattg actttgttag tgaataggca tttcatcttt ctccaatact 45240
aattcaaatt gttaaattaa taatggatag tataaatagt tattagtgat aaaatagtaa 45300
aaataattat tagaataaga gtgtagtatc atagataact ctcttctata aaaatggatt 45360
ttattcgtag aaagtatctt atatacacag tagaaaataa tatagatttt ttaaaggatg 45420
atacattaag taaagtaaac aattttaccc tcaatcatgt actagctctc aagtatctag 45480
ttagcaattt tcctcaacac gttattacta aggatgtatt agctaatacc aatttttttg 45540
ttttcataca tatggtacga tgttgtaaag tgtacgaagc ggttttacga cacgcatttg 45600
atgcacccac gttgtacgtt aaagcattga ctaagaatta tttatcgttt agtaacgcaa 45660
tacaatcgta caaggaaacc gtgcataaac taacacaaga tgaaaaattt ttagaggttg 45720
ccgaatacat ggacgaatta ggagaactta taggcgtaaa ttatgactta gttcttaatc 45780
cattatttca cggaggggaa cccatcaaag atatggaaat cattttttta aaactgttta 45840
agaaaacaga cttcaaagtt gttaaaaaat taagtgttat aagattactt atttgggctt 45900
acctaagcaa gaaagataca ggcatagagt ttgcggataa tgatagacaa gatatataca 45960
ctctatttca acaaactggt agaatagtcc atagcaatct aacagaaacg tttagagatt 46020
atatctttcc cggagataag actagctatt gggtgtggtt aaacgaaagt atagctaatg 46080
atgcggatat tgttcttaat agacacgcca ttaccatgta tgataaaatt cttagttata 46140
tatactctga gataaaacaa ggacgcgtta ataaaaacat gcttaagtta gtttatatct 46200
ttgagcctga aaaagatatc agagaacttc tgctagaaat catatatgat attcctggag 46260
atatcctatc tattattgat gcaaaaaacg acgattggaa aaaatatttt attagttttt 46320
ataaagctaa ttttattaac ggtaatacat ttattagtga tagaacgttt aacgaggact 46380
tattcagagt tgttgttcaa atagatcccg aatatttcga taatgaacga attatgtctt 46440
tattctctac gagtgctgcg gacattaaac gatttgatga gttagatatt aataacagtt 46500
atatatctaa tataatttat gaggtgaacg atatcacatt agatacaatg gatgatatga 46560
agaagtgtca aatctttaac gaggatacgt cgtattatgt taaggaatac aatacatacc 46620
tgtttttgca cgagtcggat cccatggtca tagagaacgg aatactaaag aaactgtcat 46680
ctataaaatc caagagtaga cggctgaact tgtttagcaa aaacatttta aaatattatt 46740
tagacggaca attggctcgt ctaggtcttg tgttagatga ttataaagga gacttgttag 46800
ttaaaatgat aaaccatctt aagtctgtgg aggatgtatc cgcattcgtt cgattttcta 46860
cagataaaaa ccctagtatt cttccatcgc taatcaaaac tattttagct agttataata 46920
tttccatcat cgtcttattt caaaggtttt tgagagataa tctatatcat gtagaagaat 46980
tcttggataa aagcatccat ctaaccaaga cggataagaa atatatactt caattgataa 47040
gacacggtag atcatagaac agaccaaata tattattaat aatttgtata tacatagata 47100
taattatcac acatttttga taaatgggaa ctgctgcaac aattcagact cccaccaaat 47160
taatgaataa agaaaatgca gaaatgattt tggaaaaaat tgttgatcat atagttatgt 47220
atattagtga cgaatcaagt gattcagaaa ataatcctga atatattgat tttcgtaaca 47280
gatacgaaga ctatagatct ctcattataa aaagtgatca cgagtttgta aagctatgta 47340
aaaatcatgc agagaaaagt tctccagaaa cgcaacaaat gattatcaaa cacatatacg 47400
aacaatatct tattccagta tctgaagtac tattaaaacc tataatgtcc atgggtgaca 47460
taattacata taacggatgt aaagacaatg aatggatgct agaacaactc tctaccctaa 47520
actttaacaa tctccgcaca tggaactcat gtagcatagg caatgtaacg cgtctgtttt 47580
atacattttt tagttatctg atgaaagata aactaaatat ataagtataa tcccattcta 47640
atactttaac ctgatgtatt acctgcatct tattagaata ttaacctaac taaaagacat 47700
aacatagttg ataaaaagcg gtaggatata aatattatgg ctgccaccgt tccgcgtttt 47760
gacgacgtgt acaaaaatgc acaaagaaga attctagatc aagaaacatt ttttagtaga 47820
ggtctaagta gaccgttaat gaaaaacaca tatctatttg ataattacgc gtatggatgg 47880
ataccagaaa ctgcaatttg gagtagtaga tacgcaaact tagatgcaag tgactattat 47940
cccatttcgt tgggattact taaaaagttc gagtttctca tgtctctata taaaggtcct 48000
attcccgtat atgaagaaaa agtaaatact gaattcattg ctaatggatc gttctctggt 48060
agatacgtat catatcttcg aaagttttct gcccttccaa caaacgagtt tattagtttt 48120
ttgttactga cttccattcc aatctataat atcttgttct ggtttaaaaa tactcagttt 48180
gatattacta aacacacatt attcagatac gtctatacag ataatgccaa acacctggcg 48240
ttggctaggt atatgcatca aacaggagac tataagcctt tgtttagtcg tctcaaagag 48300
aattatatat ttaccggtcc cgttccaata agtatcaaag atatagatca ccctaatctt 48360
agtagagcaa gaagtccatc cgattatgag acattagcta atattagtac tatattgtac 48420
tttaccaagt atgatccggt attaatgttt ttattgtttt acgtacctgg gtattcaatt 48480
actacaaaaa ttactccagc cgtagaatat ctaatggata aactgaatct aacaaagagc 48540
gacgtacaac tgttgtaaat tattttatgc ttcgtaaaat gtaggttttg aaccaaacat 48600
tctttcaaag aatgagatgc ataaaacttt attatccaat agattgacta tttcggacgt 48660
caatcgttta aagtaaactt cgtaaaatat tctttgatca ctgccgagtt taaaacttct 48720
atcgataatt gtttcatatg ttttaatatt tacaagtttt ttggtccatg gtacattagc 48780
cggacaaata tatgcaaaat aatatcgttc tccaagttct atagtttctg gattattttt 48840
attatattca gtaaccaaat acatattagg gttatctgcg gatttataat ttgagtgatg 48900
cattcgactc aacataaata attctagagg agacgatcta ctatcaaatt cggatcgtaa 48960
atctgtttct aaagaacgga gaatatctat acatacctga ttagaattca tccgtccttc 49020
agacaacatc tcagacagtc tggtcttgta tgtcttaatc atattcttat gaaacttgga 49080
aacatctctt ctagtttcac tagtaccttt attaattctc tcaggtacag attttgaatt 49140
cgacgatgct gagtatttca tcgttgtata tttcttcttc gattgcataa tcagattctt 49200
atataccgcc tcaaactcta ttttaaaatt attaaacaat actctattat taatcagtcg 49260
ttctaactct ttcgctattt ctatagactt atcgacatct tgactgtcta tctctgtaaa 49320
cacggagtcg gtatctccat acacgctacg aaaacgaaat ctgtaatcta taggcaacga 49380
tgttttcaca atcggattaa tatctctatc gtccatataa aatggattac ttaatggatt 49440
ggcaaaccgt aacataccgt tagataactc tgctccattt agtaccgatt ctagatacaa 49500
gatcattcta cgtcctatgg atgtgcaact cttagccgaa gcgtatgagt atagagcact 49560
atttctaaat cccatcagac catatactga gttggctact atcttgtacg tatattgcat 49620
ggaatcatag atggcctttt cagttgaact ggtagcctgt tttagcatct ttttatatct 49680
ggctctctct gccaaaaatg ttcttaatag tctaggaatg gttccttcta tcgatctatc 49740
gaaaattgct atttcagaga tgaggttcgg tagtctaggt tcacaatgaa ccgtaatata 49800
tctaggaggt ggatatttct gaagcaagag ctgattattt atttcttctt ccaatctatt 49860
ggtactaaca acgacaccga ctaatgtttc cggagataga tttccaaaga tacacacatt 49920
aggatacaga ctgttataat caaagattaa tacattatta ctaaacattt tttgttttgg 49980
agcaaatacc ttaccgcctt cataaggaaa cttttgtttt gtttctgatc taactaagat 50040
agttttagtt tccaacaata gctttaacag tggacccttg atgactgtac tcgctctata 50100
ttcgaatacc atggattgag gaagcacata tgttgacgca cccgcgtctg tttttgtttc 50160
tactccataa tactcccaca aatactgaca caaacaagca tcatgaatac agtatctagc 50220
catatctaaa gctatgttta gattataatc cttatacatc tgagctaaat caacgtcatc 50280
ctttccgaaa gataatttat atgtatcatt aggtaaagta ggacatgata gtacgacttt 50340
aaatccattt tcccaaatat ctttacgaat tactttacat ataatatcct catcaacagt 50400
cacataatta cctgtggtta aaacctttgc aaatgcagcg gctttgcctt tcgcgtccgt 50460
agtatcgtca ccgatgaacg tcatttctct aactcctcta tttaatactt tacccatgca 50520
actgaacgcg ttcttggata tagaatccaa tttgtacgaa tccaattttt cagatttttg 50580
aatgaatgaa tatagatcga aaaatatagt tccattattg ttattaacgt gaaacgtagt 50640
attggccatg ccgcctactc ccttatgact agactgattt ctctcataaa tacagagatg 50700
tacagcttcc tttttgtccg gagatctaaa gataatcttc tctcctgtta ataactctag 50760
acgattagta atatatctca gatcaaagtt atgtccgtta aaggtaacga cgtagtcgaa 50820
cgttagttcc aacaattgtt tagctattcg taacaaaact atttcagaac atagaactag 50880
ttctcgttcg taatccattt ccattagtga ctgtatcctc aaacatcctc tatcgacggc 50940
ttcttgtatt tcctgttccg ttaacatctc ttcattaatg agcgtaaaca ataatcgttt 51000
accacttaaa tcgatataac agtaacttgt atgcgagatt gggttaataa atacagaagg 51060
aaacttctta tcgaagtgac actctatatc tagaaataag tacgatcttg ggatatcgaa 51120
tctaggtatt tttttagcga aacagttacg tggatcgtca caatgataac atccattgtt 51180
aatctttgtc aaatattgct cgtccaacga gtaacatccg tctggagata tcccgttaga 51240
aatataaaac caactaatat tgagaaattc atccatggtg gcattttgta tgctgcgttt 51300
ctttggctct tctatcaacc acatatctgc gacggagcat tttctatctt taatatctag 51360
attataactt attgtctcgt caatgtctat agttctcatc tttcccaacg gcctcgcatt 51420
aaatggagga ggagacaatg actgatatat ttcgtccgta actacgtaat aaaagtaatg 51480
aggaaatcgt ataaatacgg tctcgccatt tcgacatctg gatttcagat ataaaaatct 51540
gttttcaccg tgactttcaa accaattaat gcaccgaaca tccatttata gaatttagaa 51600
atatattttc atttaaatga atcccaaaca ttggggaaga gccgtatgga ccattatttt 51660
tatagtactt tcgcaagcgg gtttagacgg caacatagaa gcgtgtaaac gaaaactata 51720
tactatagtc agcactcttc catgtcctgc atgtagacgg cacgcgacta tcgctataga 51780
ggacaataat gtcatgtcta gcgatgatct gaattatatt tattattttt tcatcagatt 51840
atttaacaat ttggcatctg atcccaaata cgcgatcgat gtgacaaagg ttaacccttt 51900
ataaacttaa cccattataa aacttatgat tagtcacgac tgaaataacc gcgtgattat 51960
tttttggtat aattctacac ggcatggttt ctgtaactat gaattcaacc cccgttacat 52020
tagtgaaatc tttaacaaac agcaagggtt cgtcaaagac ataaaactca ttgtttacaa 52080
tcgaaataga ccccctatca cacttaaaat aaaaaatatc cttatccttt accaccaaat 52140
aaaattctga ttggtcaatg tgaatgtatt cacttaacag ttccacaaat ttatttatta 52200
actccgaggc acatacatcg tcggtatttt ttatggcaaa ctttactctt ccagcatccg 52260
tttctaaaaa aatattaacg agttccattt atatcatcca atattattga aatgacgttg 52320
atggacagat gatacaaata agaaggtacg gtacctttgt ccaccatctc ctccaattca 52380
tgctctattt tgtcattaac tttaatgtat gaaaacagta cgccacatgc ttccatgaca 52440
gtgtgtaaca ctttggatac aaaatgtttg acattagtat aattgtccaa gactgtcaat 52500
ctataataga tagtagctat aatatattct atgatggtat tgaagaagat gacaatcttg 52560
gcatattgat catttaacac agacatggta tcaacagata gcttgaatga aagagaatca 52620
gtaattggaa taagcgtctt ctcgatagag tgtccgtata ccaacatgtc tgatattttg 52680
atgtattcca ttaaattatt tagttttttc tttttattct cgttaaacag catttctgtc 52740
aacggacccc aacatcgttg accgattaag ttttgattga tttttccgtg taaggcgtat 52800
ctagtcagat cgtatagcct atccaataat ccatcatctg tgcgtagatc acatcgtaca 52860
ctttttaatt ctctatagaa gagcgacaga cagcaatttc tttattctct acagatgtaa 52920
gatacttgaa gacattccta tgatgatgca gaattttgga taacacggta ttgatggtat 52980
ctgttaccat aattcctttg atggctgata gtgtcagagc acaagatttc caatctttgt 53040
tttgatatct atatcagaca gcatggtgcg tctgacaaca caaggattaa gacggaaaga 53100
tgaaatgatt ctctcaacat cttcaatgga taccttgcta ttttttctgg cattatctat 53160
atgtgcgaga atatcctcta gagaatcagt atcctttttg atgatagtgg atctcaatga 53220
catgggacgt ctaaaccttc ttattctatc accagattgc atggtgattt gtcttctttc 53280
ttttatcata atgtaatctc taaattcatc ggcaaattgt ctatatctaa aatcataata 53340
tgagatgttt acctctacaa atatctgttc gtccaatgtt agagtatcta catcagtttt 53400
gtattccaaa ttaaacatgg caacggattt aattttatat tcctctatta agtcctcgtc 53460
gataataaca gaatgtagat aatcatttaa tccatcgtac atggttggaa gatgcttgtt 53520
gacaaaatct ttaattgtct tgatgaaggt gggactatat ctaacatctt gattaataaa 53580
atttataaca ttgtccatag gatactttgt aactagtttt atacacatct cttcatcggt 53640
aagtttagac agaatatcgt gaacaggtgg tatattatat tcatcagata tacgaagaac 53700
aatgtccaaa tctatattgt ttaatatatt atatagatgt agcgtagctc ctacaggaat 53760
atctttaact aagtcaatga tttcatcaac cgttagatct attttaaagt taatcatata 53820
ggcattgatt tttaaaaggt atgtagcctt gactacattc tcattaatta accattccaa 53880
gtcactgtgt gtaagaagat tatattctat cataagcttg actacatttg gtcccgatac 53940
cattaaagaa ttcttatgat ataaggaaac agattttagg tactcatcta ctctacaaga 54000
attttggaga gccttaacga tatcagtgac gtttattatt tcaggaggaa agaatctaac 54060
attgagaata tcggaattaa tagcttccag atacagtgat tttggcaata gtccgtgtaa 54120
tccataatcc agtaacacga gctggtgctt gctagacacc ttttcaatgt ttaatttttt 54180
tgaaataagc tttgataaag ccttcctcgc aaattccgga tacatgaaca tgtcggcgac 54240
atgattaagt attgtttttt cattattttc tcaacaagtt ctcaataccc caatagatga 54300
tagaatatca cccaatgcgt ccatgttgtc tatttccaac aggtcgctat atccaccaat 54360
agaagttttt ccaaaaaaga ttctaggaac agttctacca ccagtaattt gttcaaaata 54420
gtcacgcaat tcattttcgg gtttaaattc tttaatatcg acaatttcat acgctcctct 54480
tttgaaacta aacttattta gaatatccag tgcatttcta caaaaaggac atgtatactt 54540
gacaaaaatt gtcactttgt tattggccaa cctttgttgt acaaattcct cggccatttt 54600
aatatttaag tgatataaaa ctatctcgac ttatttaact ctttagtcga gatatatgga 54660
cgcagatagc tatatgatag ccaactacag aaggcaaacg ctataaaaaa cataattacg 54720
acgagcatat ttataaatat ttttattcag cattacttga tatagtaata ttaggcacag 54780
tcaaacattc aaccactctc gatacattaa ctctctcatt ttctttaaca aattctacaa 54840
tatcttcgta aaaagattct tgaaactttt tagaatatct atcgactcta gatgaaatag 54900
cgttcgtcaa catactatgt tttgtataca taaaggcgcc cattttaaca gtttctagtg 54960
acaaaatgct agcgatccta ggatccttta gaatcacata gattgacgat tcgtctctct 55020
tagtaactct agtaaaataa tcatacaatc tagtacgcga aataatatta tccttgactt 55080
gaggagatct aaacaatcta gttttgagaa catcgataag ttcatcggga atgacataca 55140
tactatcttt aatagaactc ttttcatcca gttgaatgga ttcgtcctta accaactgat 55200
taatgagatc ttctatttta tcattttcca gatgatatgt atgtccatta aagttaaatt 55260
gtgtagcgct tctttttagt ctagcagcca atactttaac atcactaata tcgatataca 55320
aaggagatga tttatctatg gtattaagaa ttcgtttttc gacatctgtc aaaaccaatt 55380
cctttttgcc tgtatcatcc agttttccat cctttgtaaa gaaattattt tctactagac 55440
tattaataag actgataagg attcctccat aattgcacaa tccaaacttt ttaacaaaac 55500
tagactttac aagatctaca ggaatgcgta attcaggttt cttagcttgt gattttttct 55560
tttgtggaca ttttcttgtg accaactcat ctaccatttc attgatttta gcagtgaaat 55620
aagctttcaa tgcacgggca ctgatactat tgaaaacgag ttgatcttca aattccgcca 55680
tttaagttca ccaaacaact tttaaataca aatatatcaa tagtagtaga ataagaacta 55740
taaaaaaaat aataattaac caataccaac cccaacaacc ggtattatta gttgatgtga 55800
ctgttttctc atcacttaga acagatttaa caatttctat aaagtctgtc aaatcatctt 55860
ccggagaccc cataaataca ccaaatatag cggcgtacaa cttatccatt tatacattga 55920
atattggctt ttctttatcg ctatcttcat catattcatc atcaatatca acaagtccca 55980
gattacgagc cagatcttct tctacatttt cagtcattga tacacgttca ctatctccag 56040
agagtccgat aacgttagcc accacttctc tatcaatgat tagtttcttg agtgcgaatg 56100
taatttttgt ttccgttccg gatctataga agacgatagg tgtgataatt gccttggcca 56160
attgtctttc tcttttactg agtgattcta gttcaccttc tatagatctg agaatggatg 56220
attctccagt cgaaacatat tctaccatgg atccgtttaa tttgttgatg aagatggatt 56280
catccttaaa tgttttctct gtaatagttt ccaccgaaag actatgcaaa gaatttggaa 56340
tgcgttcctt gtgcttaatg tttccataga cggcttctag aagttgatac aacataggac 56400
tagccgcggt aacttttatt tttagaaagt atccatcgct tctatcttgt ttagatttat 56460
ttttataaag tttagtctct ccttccaaca taataaaagt ggaagtcatt tgactagata 56520
aactatcagt aagttttata gagatagacg aacaattagc gtattgagaa gcatttagtg 56580
taacgtattc gatacatttt gcattagatt tactaatcga ttttgcatac tctataacac 56640
ccgcacaagt ctgtagagaa tcgctagatg cagtaggtct tggtgaagtt tcaactctct 56700
tcttgattac cttactcatg attaaaccta aataattgta ctttgtaata taatgatata 56760
tattttcact ttatctcatt tgagaataaa aatgtttttg tttaaccact gcatgatgta 56820
cagatttcgg aatcgcaaac caccagtggt tttattttat ccttgtccaa tgtgaattga 56880
atgggagcgg atgcgggttt cgtacgtaga tagtacattc ccgtttttag accgagactc 56940
catccgtaaa aatgcatact cgttagtttg gaataactcg gatctgctat atggatattc 57000
atagattgac tttgatcgat gaaggctccc ctgtctgcag ccatttttat gatcgtcttt 57060
tgtggaattt cccaaatagt tttataaact cgcttaatat cttctggaag gtttgtattc 57120
tgaatggatc caccatctgc cataatccta ttcttgatct catcattcca taattttctc 57180
tcggttaaaa ctctaaggag atgcggatta actacttgaa attctccaga caatactctc 57240
cgagtgtaaa tattactggt atacggttcc accgactcat tatttcccaa aatttgagca 57300
gttgatgcag tcggcatagg tgccaccaat aaactatttc taagaccgta tgttctgatt 57360
ttatctttta gaggttccca attccaaaga tccgacggta caacattcca aagatcatat 57420
tgtagaatac cgttactggc gtacgatcct acatatgtat cgtatggtcc ttccttctca 57480
gctagttcac aactcgcctc taatgcaccg taataaatgg tttcgaagat cttcttattt 57540
agatcttgtg cttccaggct atcaaatgga taatttaaga gaataaacgc gtccgctaat 57600
ccttgaacac caataccgat aggtctatgt ctcttattag agatttcagc ttctggaata 57660
ggataataat taatatctat aattttattg agatttctga caattacttt gaccacatcc 57720
ttcagtttga gaaaatcaaa tcgcccatct attacaaaca tgttcaaggc aacagatgcc 57780
agattacaaa cggctacctc attagcatcc gcatattgta ttatctcagt gcaaagatta 57840
ctacacttga tagttcctaa attttgttga ttactctttt tgttacacgc atccttataa 57900
agaatgaatg gagtaccagt ttcaatctga gattctataa tcgctttcca gacgactcga 57960
gcctttatta tagatttgta tctcctttct ctttcgtata gtgtatacaa tcgttcgaac 58020
tcgtctcccc aaacattgtc caatccagga cattcatccg gacacatcaa cgaccactct 58080
ccgtcatcct tcactcgttt cataaagaga tcaggaatcc aaagagctat aaatagatct 58140
ctggttctat gttcctcgtt tcctgtattc tttttaagat cgaggaacgc cataatatca 58200
gaatgccacg gttccaagta tatggccata actccaggcc gtttgtttcc tccctgatct 58260
atgtatctag cggtgttatt ataaactctc aacattggaa taataccgtt tgatatacca 58320
ttggtaccgg agatatagct tccactggca cgaatattac taattgatag acctattccc 58380
cctgccattt tagagattaa tgcgcatcgt tttaacgtgt catagatacc ctctatgcta 58440
tcatcgatca tgttaagtag aaaacagcta gacatttggt gacgactagt tcccgcatta 58500
aataaggtag gagaagcgtg cgtaaaccat ttttcagaaa gtagattgta cgtctcaata 58560
gctgagtcta tatcccattg atgaattcct actgcgacac gcattaacat gtgctgaggt 58620
ctttcaacga tcttgttgtt tattttcaac aagtaggatt tttccaaagt tttaaaacca 58680
aaatagttgt atgaaaagtc tcgttcgtaa ataataaccg agttgagttt atccttatat 58740
ttgttaacta tatccatggt gatacttgaa ataatcggag aatgtttccc atttttagga 58800
ttaacatagt tgaataaatc ctccatcact tcactaaata gtttttttgt ttccttgtgt 58860
agatttgata cggctattct ggcggctaga atggcataat ccggatgttg tgtagtacaa 58920
gtggctgcta tttcggctgc cagagtgtcc aattctaccg ttgttactcc attatatatt 58980
ccttgaataa ccttcatagc tattttaata ggatctatat gatccgtgtt taagccataa 59040
cataattttc taatacgaga cgtgatttta tcaaacatga cattttcctt gtatccattt 59100
cgtttaatga caaacatttt tgttggtgta ataaaaaaaa ttatttaact tttcattaat 59160
agggatttga cgtatgtagc gtacaaaatt atcgttcctg gtatatagat aaagagtcct 59220
atatatttga aaatcgttac ggctcgatta aactttaatg attgcatagt gaatatatca 59280
ttaggattta actccttgac tatcatggcg gcgccagaaa ttaccatcaa aagcattaat 59340
acagttatgc cgatcgcagt tagaacggtt atagcatcca ccatttatat ctaaaaatta 59400
gatcaaagaa tatgtgacaa agtcctagtt gtatactgag aattgacgaa acaatgtttc 59460
ttacatattt tttttttatt agtaaccgac ttaatagtag gaactggaaa actagacttg 59520
attattctat aagtatagat acccttccaa ataatattct ctttgataaa agttccagaa 59580
aatgtagaat tttttaaaaa gttatctttt gctattacca agattgtgtt tagacgctta 59640
ttattaatat gagtgatgaa atccacaccg cctctagata tcgcttttat ttccacatta 59700
gatggtaaat ccaatagtga aactatcttt ttaggaatgt atggactcgc gtttagagga 59760
gtgaacgtct taggcgtcgg aaaggggccg gccttttttt ctagacacta aataaatagt 59820
aagattaaat taattataaa attatgtata taatattaat tataaaatta tgtatatgat 59880
ttactaactt tagttagata aattaataat acataaattt tagtatatta atattataaa 59940
ttaataatac ataaatttta gtatattaat attatatttt aaatatttat ttagtgtcta 60000
gaaaaaaagg cctagcaggc c 60021
<210> 13
<211> 63035
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA fragment 2
<400> 13
ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60
attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120
aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180
gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccataa 240
aaatgttttt gtttaaccac tgcatgatgt acagatttcg gaatcgcaaa ccaccagtgg 300
ttttatttta tccttgtcca atgtgaattg aatgggagcg gatgcgggtt tcgtacgtag 360
atagtacatt cccgttttta gaccgagact ccatccgtaa aaatgcatac tcgttagttt 420
ggaataactc ggatctgcta tatggatatt catagattga ctttgatcga tgaaggctcc 480
cctgtctgca gccattttta tgatcgtctt ttgtggaatt tcccaaatag ttttataaac 540
tcgcttaata tcttctggaa ggtttgtatt ctgaatggat ccaccatctg ccataatcct 600
attcttgatc tcatcattcc ataattttct ctcggttaaa actctaagga gatgcggatt 660
aactacttga aattctccag acaatactct ccgagtgtaa atattactgg tatacggttc 720
caccgactca ttatttccca aaatttgagc agttgatgca gtcggcatag gtgccaccaa 780
taaactattt ctaagaccgt atgttctgat tttatctttt agaggttccc aattccaaag 840
atccgacggt acaacattcc aaagatcata ttgtagaata ccgttactgg cgtacgatcc 900
tacatatgta tcgtatggtc cttccttctc agctagttca caactcgcct ctaatgcacc 960
gtaataaatg gtttcgaaga tcttcttatt tagatcttgt gcttccaggc tatcaaatgg 1020
ataatttaag agaataaacg cgtccgctaa tccttgaaca ccaataccga taggtctatg 1080
tctcttatta gagatttcag cttctggaat aggataataa ttaatatcta taattttatt 1140
gagatttctg acaattactt tgaccacatc cttcagtttg agaaaatcaa atcgcccatc 1200
tattacaaac atgttcaagg caacagatgc cagattacaa acggctacct cattagcatc 1260
cgcatattgt attatctcag tgcaaagatt actacacttg atagttccta aattttgttg 1320
attactcttt ttgttacacg catccttata aagaatgaat ggagtaccag tttcaatctg 1380
agattctata atcgctttcc agacgactcg agcctttatt atagatttgt atctcctttc 1440
tctttcgtat agtgtataca atcgttcgaa ctcgtctccc caaacattgt ccaatccagg 1500
acattcatcc ggacacatca acgaccactc tccgtcatcc ttcactcgtt tcataaagag 1560
atcaggaatc caaagagcta taaatagatc tctggttcta tgttcctcgt ttcctgtatt 1620
ctttttaaga tcgaggaacg ccataatatc agaatgccac ggttccaagt atatggccat 1680
aactccaggc cgtttgtttc ctccctgatc tatgtatcta gcggtgttat tataaactct 1740
caacattgga ataataccgt ttgatatacc attggtaccg gagatatagc ttccactggc 1800
acgaatatta ctaattgata gacctattcc ccctgccatt ttagagatta atgcgcatcg 1860
ttttaacgtg tcatagatac cctctatgct atcatcgatc atgttaagta gaaaacagct 1920
agacatttgg tgacgactag ttcccgcatt aaataaggta ggagaagcgt gcgtaaacca 1980
tttttcagaa agtagattgt acgtctcaat agctgagtct atatcccatt gatgaattcc 2040
tactgcgaca cgcattaaca tgtgctgagg tctttcaacg atcttgttgt ttattttcaa 2100
caagtaggat ttttccaaag ttttaaaacc aaaatagttg tatgaaaagt ctcgttcgta 2160
aataataacc gagttgagtt tatccttata tttgttaact atatccatgg tgatacttga 2220
aataatcgga gaatgtttcc catttttagg attaacatag ttgaataaat cctccatcac 2280
ttcactaaat agtttttttg tttccttgtg tagatttgat acggctattc tggcggctag 2340
aatggcataa tccggatgtt gtgtagtaca agtggctgct atttcggctg ccagagtgtc 2400
caattctacc gttgttactc cattatatat tccttgaata accttcatag ctattttaat 2460
aggatctata tgatccgtgt ttaagccata acataatttt ctaatacgag acgtgatttt 2520
atcaaacatg acattttcct tgtatccatt tcgtttaatg acaaacattt ttgttggtgt 2580
aataaaaaaa attatttaac ttttcattaa tagggatttg acgtatgtag cgtacaaaat 2640
tatcgttcct ggtatataga taaagagtcc tatatatttg aaaatcgtta cggctcgatt 2700
aaactttaat gattgcatag tgaatatatc attaggattt aactccttga ctatcatggc 2760
ggcgccagaa attaccatca aaagcattaa tacagttatg ccgatcgcag ttagaacggt 2820
tatagcatcc accatttata tctaaaaatt agatcaaaga atatgtgaca aagtcctagt 2880
tgtatactga gaattgacga aacaatgttt cttacatatt ttttttttat tagtaaccga 2940
cttaatagta ggaactggaa aactagactt gattattcta taagtataga tacccttcca 3000
aataatattc tctttgataa aagttccaga aaatgtagaa ttttttaaaa agttatcttt 3060
tgctattacc aagattgtgt ttagacgctt attattaata tgagtgatga aatccacacc 3120
gcctctagat atcgctttta tttccacatt agatggtaaa tccaatagtg aaactatctt 3180
tttaggaatg tatggactcg cgtttagagg agtgaacgtc ttaggcgtcg gaaaggatga 3240
ttcatcaaac gaataaacaa tttcacaaat ggatgttaat gtattagtag gaaatttttt 3300
gacgctagtg gaattgaaga ttctaatgga tgatgttcta cctatttcat ccgataacat 3360
gttaatttcc gacaccaacg gttttaatat ttcgatgata tacggtagtc tctctttcgg 3420
acttatatag cttattccac aatacgagtc attatatact ccaaaaaaca aaataactag 3480
tataaaatct gtatcgaatg ggaaaaacga aattatcgac ataggtatag aatctggaac 3540
attgaacgta ttaatactta attctttttc tgtggtaagt accgataggt tattgacatt 3600
gtatggtttt aaatattcta taacttgaga cttgatagat attagtgatg aattgaaaat 3660
tatttttatc accacgtgtg tttcaggatc atcgtcgacg cccgtcaacc aaccgaatgg 3720
agtaaaataa atatcattaa tatatgctct agatattagt atttttatca atcctttgat 3780
tatcatcttc tcgtaggcga atgattccat gatcaagagt gatttaagaa catcctccgg 3840
agtattaatg ggcttagtaa acagtccatc gttgcaataa taaaagttat ccaagttaaa 3900
ggatattatg cattcgttta aagatatcac ctcatctgac ggagacaatt ttttggtagg 3960
ttttagagac tttgaagcta cttgtttaac aaagttattc atcgtcgttt actattctat 4020
ttaattttgt agttaattta tcacatatca cattaattga ctttttggtc catttttcca 4080
tacgtttata ttcttttaat cctgcgttat ccgtttccgt tatatccagg gatagatctt 4140
gcaagttaaa tagaatgctc ttaaataatg tcattttctt atccgctaaa aatttaaaga 4200
atgtataaac ctttttcaga gatttgaaac tcttaggtgg tgtcctagta cacaatatca 4260
taaacaaact aataaacatt ccacattcag attccaacag ctgattaact tctacattaa 4320
tacagcctat tttcgctcca aatgtacatt cgaaaaatct gaataaaaca tcgatgtcac 4380
aatttgtatt atccaataca gaatgtttgt gattcgtgtt aaaaccatcg gagaaggaat 4440
aaaaataaaa attattatag tggtggaatt cagttggaat attgcctccg gagtcataaa 4500
aggatactaa acattgtttt ttatcataaa ttacacattt ccaatgagac aaataacaaa 4560
atccaaacat tacaaatcta gaggtagaac ttttaatttt gtctttaagt atatacgata 4620
agatatgttt attcataaac gcgtcaaatt tttcatgaat cgctaaggag tttaagaatc 4680
tcatgtcaaa ttgtcctata taatccactt cggatccata agcaaactga gagactaagt 4740
tcttaatact tcgattgctc atccaggctc ctctctcagg ctctattttc atcttgacga 4800
cctttggatt ttcaccagta tgtattcctt tacgtgataa atcatcgatt ttcaaatcca 4860
tttgtgagaa gtctatcgcc ttagatactt tttcccgtag tcgaggttta aagaaatacg 4920
ctaacggtat actagtaggt aactcaaaga catcatatat agaatggtaa cgcgtcttta 4980
actcgtcggt taactctttc ttttgatcga gttcgtcgct actattgggt ctgctcaggt 5040
gccccgactc tactagttcc aacatcatac cgataggaat acaagacact ttgccggcgg 5100
ttgtagattt atcatatttc tccactacat atccgttaca atttgttaaa aatttagata 5160
catctatatt gctacataat ccagctagtg aatatatatg acataataaa ttggtaaatc 5220
ctagttctgg tattttacta attactaaat ctgtatatct ttccatttat catggaaaag 5280
aatttaccag atatcttctt ttttccaaac tgcgttaatg tattctctta caaatattca 5340
caagatgaat tcagtaatat gagtaaaacg gaacgtgata gtttctcatt ggcggtgttt 5400
ccagttataa aacatagatg gcataacgca cacgttgtaa aacataaagg aatatacaaa 5460
gttagtacag aagcacgtgg aaaaaaagta tctcctccat cactaggaaa acccgcacac 5520
ataaacctaa ccgcgaagca atatatatac agtgaacaca caataagctt tgaatgttat 5580
agttttctaa aatgtataac aaatacagaa atcaattcgt tcgatgagta tatattaaga 5640
ggactattag aagctggtaa tagtttacag atattttcca attccgtagg taaacgaaca 5700
gatactatag gtgtactagg gaataagtat ccatttagca aaattccatt ggcctcatta 5760
actcctaaag cacaacgaga gatattttca gcgtggattt ctcatagacc tgtagtttta 5820
actggaggaa ctggagtggg taagacgtca caggtaccca agttattgct ttggtttaat 5880
tatttatttg gtggattctc tactctagat aaaatcactg actttcacga aagaccagtc 5940
attctatctc ttcctaggat agctttagtt agattgcata gcaataccat tttaaaatca 6000
ttgggattta aggtactaga tggatctcct atttctttac ggtacggatc tataccggaa 6060
gaattaataa acaaacaacc aaaaaaatat ggaattgtat tttctaccca taagttatct 6120
ctaacaaaac tatttagtta tggcactctt attatagacg aagttcatga gcatgatcaa 6180
ataggagata ttattatagc agtagcgaga aagcatcata cgaaaataga ttctatgttt 6240
ttaatgactg ccacgttaga ggatgacagg gaacggctaa aagtattttt acctaatccc 6300
gcatttatac atattcctgg agatacactg tttaaaatta gcgaggtatt tattcataat 6360
aagataaatc catcttccag aatggcatac atagaagaag aaaagagaaa tttagttact 6420
gctatacaga tgtatactcc tcctgatgga tcatccggta tagtctttgt ggcatccgtt 6480
gcacagtgtc acgaatataa atcatattta gaaaaaagat taccgtatga tatgtatatt 6540
attcatggta aggtcttaga tatagacgaa atattagaaa aagtgtattc atcacctaat 6600
gtatcgataa ttatttctac tccttatttg gaatccagcg ttactatacg caatgttaca 6660
cacatttatg atatgggtag agtttttgtc cccgctcctt ttggaggatc gcaagaattt 6720
atttctaaat ctatgagaga tcaacgaaaa ggaagagtag gaagagttaa tcctgggaca 6780
tacgtatatt tctatgatct gtcttatatg aagtctatac agcgaataga ttcagaattt 6840
ctacataatt atatattgta cgctaataag tttaatctaa cactccccga agatttgttt 6900
ataatcccta caaatttgga tattctatgg cgtacaaagg aatatataga ctcgttcgat 6960
attagtacag aaacatggaa taaattatta tccaattatt atatgaagat gatagagtat 7020
gctaaacttt atgtactaag tcctattctc gctgaggagt tggataattt tgagaggacg 7080
ggagaattaa ctagtattgt acaagaagcc attttatctc taaatttacg aattaagatt 7140
ttaaatttta aacataaaga tgatgatacg tatatacact tttgtaaaat attattcggt 7200
gtctataacg gaacaaacgc tactatatat tatcatagac ctctaacggg atatatgaat 7260
atgatttcag atactatatt tgttcctgta gataataact aaaaatcaaa ctctaatgac 7320
cacatctttt tttagagatg aaaaattttc cacatctcct tttgtagaca cgactaaaca 7380
ttttgcagaa aaaagtttat tagtgtttag ataatcgtat acttcatcag tgtagatagt 7440
aaatgtgaac agataaaagg tattcttgct caatagattg gtaaattcca tagaatatat 7500
taatcctttc ttcttgagat cccacatcat ttcaaccaga gacgttttat ccaatgattt 7560
acctcgtact ataccacata caaaactaga ttttgcagtg acgtcgtatc tggtattcct 7620
accaaacaaa attttacttt tagttctttt agaaaattct aaggtagaat ctctatttgc 7680
caatatgtca tctatggaat taccactagc aaaaaatgat agaaatatat attgatacat 7740
cgcagctggt tttgatctac tatactttaa aaacgaatca gattccataa ttgcctgtat 7800
atcatcagct gaaaaactat gttttacacg tattccttcg gcatttcttt ttaatgatat 7860
atcttgttta gacaatgata aagttatcat gtccatgaga gacgcgtctc cgtatcgtat 7920
aaatatttca ttagatgtta gacgcttcat taggggtata cttctataag gtttcttaat 7980
cagtccatca ttggttgcgt caagaactac tatcggatgt tgttgggtat ctctagtgtt 8040
acacatggcc ttactaaagt ttgggtaaat aactatgata tctctattaa ttatagatgc 8100
atatatttca tttgtcaagg atattagtat cgacttgcta tcgtcattaa tacgtgtaat 8160
gtaatcatat aaatcatgcg atagccaagg aaaatttaaa tagatgttca tcatataatc 8220
gtcgctataa ttcatattaa tacgttgaca ttgactaatt tgtaatatag cctcgccacg 8280
aagaaagctc tcgtattcag tttcatcgat aaaggatacc gttaaatata actggttgcc 8340
gatagtctca tagtctatta agtggtaagt ttcgtacaaa tacagaatcc ctaaaatatt 8400
atctaatgtt ggattaatct ttaccataac tgtataaaat ggagacggag tcataactat 8460
tttaccgttt gtacttactg gaatagacga aggaataatc tccggacatg ctggtaaaga 8520
cccaaatgtc tgtttgaaga aatccaatgt tccaggtcct aatctcttaa caaaaattac 8580
gatattcgat cccgatatcc tttgcattct atttaccagc atatcacgaa ctatattaag 8640
attatctatc atgtctattc tcccaccgtt atataaatcg cctccgctaa gaaacgttag 8700
tatatccata caatggaata cttcatttct aaaatagtat tcgttttcta attctttaat 8760
gtgaaatcgt atactagaaa gggaaaaatt atctttgagt tttccgttag aaaagaacca 8820
cgaaactaat gttctgattg cgtccgattc cgttgctgaa ttaatggatt tacaccaaaa 8880
actcatataa cttctagatg tagaagcatt cgctaaaaaa ttagtagaat caaaggatat 8940
aagtagatgt tccaacaagt gagcaattcc caagatttca tctatatcat tctcgaatcc 9000
gaaattagaa attcccaagt agatatcctt tttcatccga tcgttgatga aaatacgaac 9060
tttattcggt aagacaatca tttactaagg agtaaaatag gaagtaatgt tcgtatgtcg 9120
ttatcatcgt ataaattaaa ggtgtgtttt ttaccattaa gtgacattat aattttacca 9180
atattggaat tataatatag gtgtatttgc gcactcgcga cggttgatgc atcggtaaat 9240
atagctgtat ctaatgttct agtcggtatt tcatcatttc gctgtctaat aatagcgttt 9300
tctctatctg tttccattac agctgcctga agtttattgg tcggataata tgtaaaataa 9360
taagaaatac atacgaataa caaaaataaa ataagatata ataaagatgc catttagaga 9420
tctaattttg tttaacttgt ccaaattcct acttacagaa gatgaggaat cgttggagat 9480
agtgtcttcc ttatgtagag gatttgaaat atcttatgat gacttgataa cttactttcc 9540
agataggaaa taccataaat atatttctaa agtatttgaa catgtagatt tatcggagga 9600
attaagtatg gaattccatg atacaactct gagagattta gtctatctta gattgtacaa 9660
gtattccaag tgtatacggc cgtgttataa attaggagat aatctaaaag gcatagttgt 9720
tataaaggac aggaatattt atattagaga agcaaatgat gacttgatag aatatctcct 9780
caaggaatac actcctcaga tttatacata ttctaatgag cgcgtcccca taactggttc 9840
aaaattaatt ctttgtggat tttctcaagt tacatttatg gcgtatacaa cgtcgcatat 9900
aacaacaaat aaaaaggtag atgttctcgt ttccaaaaaa tgtatagatg aactagtcga 9960
tccaataaat tatcaaatac ttcaaaattt atttgataaa ggaagcggaa caataaacaa 10020
aatactcagg aagatatttt attcggtaac cggtggccaa actccataat ttgctttttc 10080
tatttcggat tttagaattt ccaaattcac cagcgattta tcggttttgg tgaaatccaa 10140
ggatttatta atgtccacaa atgccatttg ttttgtctgt ggattgtatt tgaaaatgga 10200
aacgatgtag ttagatagat gcgctgcaaa gtttcctatt agggttccgc gctttacgtc 10260
acccagcata cttgaatcac catcctttaa aaaaaatgat aagatatcaa catggagtat 10320
atcatactcg gattttaatt cttctactgc atcactgaca ttttcacaaa tactacaata 10380
cggtttaccg aaaataatca gtacgttctt catttatggg tatcaaaaac ttaaaatcgt 10440
tactgctgga aaataaatca ctgacgatat tagatgataa tttatacaaa gtatacaatg 10500
gaatatttgt ggatacaatg agtatttata tagccgtcgc caattgtgtc agaaacttag 10560
aagagttaac tacggtattc ataaaatacg taaacggatg ggtaaaaaag ggagggcatg 10620
taaccctttt tatcgataga ggaagtataa aaattaaaca agacgttaga gacaagagac 10680
gtaaatattc taaattaacc aaggacagaa aaatgctaga attagaaaag tgtacatccg 10740
aaatacaaaa tgttaccgga tttatggaag aagaaataaa ggcagaaatg caattaaaaa 10800
tcgataaact cacatttcaa atatatttat ctgattctga taacataaaa atatcattga 10860
atgagatact aacacatttc aacaataatg agaatgttac attattttat tgtgatgaac 10920
gagacgcaga attcgttatg tgtctcgagg ctaaaacaca tttctctacc acaggagaat 10980
ggccgttgat aataagtacc gatcaggata ctatgctatt tgcatctact gataatcatc 11040
ctaagatgat aaaaaactta actcaactgt ttaaatttgt tccctcggca gaggataact 11100
atttagcaaa attaacggcg ttagtgaatg gatgtgattt ctttcctgga ctctatgggg 11160
catctataac acccaccaac ttaaacaaaa tacaattgtt tagtgatttt acaatcgata 11220
atatagtcac tagtttggca attaaaaatt attatagaaa gactaactct accgtagacg 11280
tgcgtaatat tgttacgttt ataaacgatt acgctaattt agacgatgtc tactcgtatg 11340
ttcctccttg tcaatgcact gttcaagaat ttatattttc cgcattagat gaaaaatgga 11400
acaattttaa atcatcttat ttagagaccg ttccgttacc ctgccaatta atgtatgcat 11460
tagaaccacg caaggagatt gatgtttcag aagttaaaac tttatcatct tatatagatt 11520
tcgaaaatac taaatcagat atcgatgtta taaaatctat atcttcgatc ttcggatatt 11580
ctaacgaaaa ctgtaacact atagtgttcg gcatctataa ggataattta ctactgagta 11640
taaatagttc attttacttt aacgatagtc tgttaataac caatactaaa agtgataata 11700
taataaatat aggttactag attaaaaatg gtgttccaac tcgtgtgctc tacgtgcggc 11760
aaagatattt ctcacgaacg atataaattg attatacgaa aaaaatcatt aaaggatgta 11820
ctcgtcagtg taaagaacga atgttgtagg ttaaaattat ctacacaaat agaacctcaa 11880
cgtaacttaa cagtgcaacc tctattggat ataaactaat atggatccgg ttaattttat 11940
caagacatat gcgcctagag gttctattat ttttattaat tataccatgt cattaacaag 12000
tcatttgaat ccatcgatag aaaaacatgt gggtatttat tatggtacgt tattatcgga 12060
acacttggta gttgaatcta cctatagaaa aggagttcga atagtcccat tggatagttt 12120
ttttgaagga tatcttagtg caaaagtata catgttagag aatattcaag ttatgaaaat 12180
agcagctgat acgtcattaa ctttattggg tattccgtat ggatttggtc ataatagaat 12240
gtattgtttt aaattggtag ctgaatgtta taaaaatgcc ggtattgata catcgtctaa 12300
acgaatatta ggtaaagata tttttctgag ccaaaacttc acagatgata atagatggat 12360
aaagatatat gattctaata atttaacatt ttggcaaatt gattacctta aagggtgagt 12420
taatatgcat aactactcct ccgttgtttt ttccctcgtt ctttttctta acgttgtttg 12480
ccatcactct cataatgtaa agatattcta aaatggtaaa cttttgcata tcggacgcag 12540
aaattggtat aaatgttgta attgtattat ttcccgtcaa tggactagtc acagctccat 12600
cagttttata tcctttagag tatttctcac tcgtgtctaa cattctagag cattccatga 12660
tctgtttatc gttgatattg gccggaaaga tagatttttt attttttatt atattactat 12720
tggcaattgt agatataact tctggtaaat atttttctac cttttcaatc tcttctattt 12780
tcaagccggc tatatattct gctatattgt tgctagtatc aatacctttt ctggctaaga 12840
agtcatatgt ggtattcact atatcagttt taactggtag ttccattagc ctttccactt 12900
ctgcagaata atcagaaatt ggttctttac cagaaaatcc agctactata ataggctcac 12960
cgatgatcat tggcaaaatc ctatattgta ccagattaat gagagcatat ttcatttcca 13020
ataattctgc tagttcttga gacattgatt tatttgatga atctagttgg ttctctagat 13080
actctaccat ttctgccgca tacaataact tgttagataa aatcagggtt atcaaagtgt 13140
ttagcgtggc tagaatagtg ggcttgcatg tattaaagaa tgcggtagta tgagtaaacc 13200
gttttaacga attatatagt ctccagaaat ctgtggcgtt acatacatga gccgaatgac 13260
atcgaagatt gtccaatatt tttaatagct gctctttgtc cattatttct atatttgact 13320
cgcaacaatt gtagatacca ttaatcactg attccttttt cgatgccgga caatagcaca 13380
attgtttagc tttggactct atgtattcag aattaataga tatatctctc aatacagatt 13440
gcactataca ttttgaaact atgtcaaaaa ttgtagaacg acgctgttct gcagccattt 13500
aactttaaat aatttacaaa aatttaaaat gagcatccgt ataaaaatcg ataaactgcg 13560
ccaaattgtg gcatattttt cagagttcag tgaagaagta tctataaatg tagactcgac 13620
ggatgagtta atgtatattt ttgccgcctt gggcggatct gtaaacattt gggccattat 13680
acctctcagt gcatcagtgt tctaccgcgg agccgaaaac attgtgttta atcttcctgt 13740
gtccaaggta aaatcgtgtt tgtgtagttt tcacaatgat gccatcatag atatagaacc 13800
tgatctggaa aataatctag taaaactttc tagttatcat gtagtaagtg tcgattgtaa 13860
caaggaactg atgcctatta ggacagatac tactatttgt ctaagtatag atcaaaagaa 13920
atcttacgtg tttaattttc acaagtatga agaaaaatgt tgtggtagaa ccgtcattca 13980
tttagaatgg ttgttgggct ttatcaagtg tattagtcag catcagcatt tggctattat 14040
gtttaaagat gacaatatta ttatgaagac tcctggtaat actgatgcgt tttccaggga 14100
atattctatg actgaatgtt ctcaagaact acaaaagttt tctttcaaaa tagctatctc 14160
gtctctcaac aaactacgag gattcaaaaa gagagtcaat gtttttgaaa ctagaatcgt 14220
aatggataat gacgataaca ttctaggaat gttgttttcg gatagagttc aatcctttaa 14280
gatcaacatc tttatgacgt ttttagatta atactttcaa tgagataaat atgggtggca 14340
gagtaagtgt tgagctccct aaacgggatc cgcctccggg agtacccact gatgagatgt 14400
tattaaacgt ggataaaatg catgacgtga tagctcccgc taagctttta gaatatgtgc 14460
atataggacc actagcaaaa gataaagagg ataaagtaaa gaaaagatat ccagagttta 14520
gattagtcaa cacaggaccc ggtggtcttt cggcattgtt aagacaatcg tataatggaa 14580
ccgcacccaa ttgctgtcgc acttttaatc gtactcatta ttggaaaaag gatggaaaga 14640
tatcagataa gtatgaagag ggtgcagtat tagaatcgtg ttggccagac gttcacgaca 14700
ctggaaaatg cgatgttgat ttattcgact ggtgtcaggg ggatacgttc gatagaaaca 14760
tatgccatca gtggatcggt tcagccttta ataggagtga tagaactgta gagggtcaac 14820
aatcgttaat aaatctgtat aataagatgc aaacattatg tagtaaagat gctagtgtac 14880
caatatgtga atcatttttg catcatttac gcgcacacaa tacagaagat agcaaagaga 14940
tgatcgatta tattctaaga caacagtctg cggactttaa acagaaatat atgagatgta 15000
gttatcccac tagagataag ttagaagagt cattaaaata tgcggaacct cgagaatgtt 15060
gggatccaga gtgttcgaat gccaatgtta atttcttact aacacgtaat tataataatt 15120
taggactttg caatattgta cgatgtaata ctagcgtgaa caacttacag atggataaaa 15180
cttcctcatt aagattgtca tgtggattaa gcaatagtga tagattttct actgttcccg 15240
tcaatagagc aaaagtagtt caacataata ttaaacattc gttcgaccta aaattgcatt 15300
tgatcagttt attatctctc ttggtaatat ggatactaat tgtagctatt taaatgggtg 15360
ccgcggcaag catacagacg acggtgaata cactcagcga acgtatctcg tctaaattag 15420
aacaagaagc gaacgctagt gctcaaacaa aatgtgatat agaaatcgga aatttttata 15480
tccgacaaaa ccatggatgt aacctcactg ttaaaaatat gtgctctgcg gacgcggatg 15540
ctcagttgga tgctgtgtta tcagccgcta cagaaacata tagtggatta acaccggaac 15600
aaaaagcata cgtaccagct atgtttactg ctgcgttaaa cattcagacg agtgtaaaca 15660
ctgttgttag agattttgaa aattatgtga aacagacttg taattctagc gcggtcgtcg 15720
ataacaaatt aaagatacaa aacgtaatca tagatgaatg ttacggagcc ccaggatctc 15780
caacaaattt ggaatttatt aatacaggat ctagcaaagg aaattgtgcc attaaagcgt 15840
tgatgcaatt gacgactaag gccactactc aaatagcacc tagacaagtt gctggtacag 15900
gagttcagtt ttatatgatt gttatcggtg ttataatatt ggcagcgttg tttatgtact 15960
atgccaagcg tatgttgttc acatccacca atgataaaat caaacttatt ttagccaata 16020
aggaaaacgt ccattggact acttacatgg acacattctt tagaacttct ccgatggtta 16080
ttgctaccac ggatatgcaa aactgaaaat atattgataa tattttaata gattaacatg 16140
gaagttatcg ctgatcgtct agacgatata gtgaaacaaa atatagcgga tgaaaaattt 16200
gtagattttg ttatacacgg tctagagcat caatgtcctg ctatacttcg accattaatt 16260
aggttgttta ttgatatact attatttgtt atagtaattt atatttttac ggtacgtcta 16320
gtaagtagaa attatcaaat gttgttggcg ttggtggcgc tagtcatcac attaactatt 16380
ttttattact ttatactata atagtactag actgacttct aacaaacatc tcacctgcca 16440
taaataaatg cttgatatta aagtcttcta tttctaacac tattccatct gtggaaaata 16500
atactctgac attatcgcta attgacacat cggtgagtga tatgcctata aagtaataat 16560
cttctttggg cacatatacc agtgtaccag gttctaacaa cctatttact ggtgctcctg 16620
tagcatactt tttctttacc ttgagaatat ccatcgtttg cttggtcaat agcgatatgt 16680
gattttttat caaccactca aaaaagtaat tggagtgttc atatcctcta cgggctattg 16740
tctcatggcc gtgtatgaaa tttaagtaac acgactgtgg tagatttgtt ctatagagcc 16800
ggttgccgca aatagataga actaccaata tgtctgtaca aatgttaaac attaattgat 16860
taacagaaaa aacaatgttc gttctgggaa tagaaaccag atcaaaacaa aattcgttag 16920
aatatatgcc acgtttatac atggaatata aaataactac agtttgaaaa ataacagtat 16980
catttaaaca tttaacttgc ggggttaatt tcacaacttt actgttttta aactgttcaa 17040
aatatagcat cgatccatga gaaatacgtt tagccgcctt taatagagga aatcccaccg 17100
cctttctgga tctcaccaac gacgatagtt ctgaccagca acttatttct tcatcatcca 17160
cctgttttaa catataatag gcaggagata gatatccgtc attgcaatat tccttttcgt 17220
aggcacacaa tctaatattg ataaaatctc cattctcttc tctgcattta ttatcttgtt 17280
tcggtggctg attaggctgt agtcttggtt taggctttgg tatatcgttg ttgaatctat 17340
tttggtcatt aaatctttca tttcttcctg gtatatttct atcacctcgt ttggttggat 17400
ttttgtctat attatcgttt gtaacatcgg tacgggtatt catttatcac aaaaaaaact 17460
tctctaaatg agtctactgc tagaaaacct catcgaagaa gataccatat tttttgcagg 17520
aagtatatct gagtatgatg atttacaaat ggttattgcc ggcgcaaaat ccaaatttcc 17580
aagatctatg ctttctattt ttaatatagt acctagaacg atgtcaaaat atgagttgga 17640
gttgattcat aacgagaata tcacaggggc aatgtttacc acaatgtata atataagaaa 17700
caatttgggt ctaggagatg ataaactaac tattgaagcc attgaaaact atttcttgga 17760
tcctaacaat gaggttatgc ctcttatcat taataatacg gatatgactg ccgtcattcc 17820
taaaaaaagt ggtaggagaa agaataagaa catggttatt ttccgtcaag gatcatcacc 17880
tatcttgtgt attttcgaaa ctcgtaaaaa gattaatatt tataaagaaa atatggaatc 17940
cgcgtcgact gagtatacac ctatcggaga caacaaggct ttgatatcta aatatgcggg 18000
aattaatgtc ctgaatgtgt attctccttc cacatccatg agattgaatg ccatttacgg 18060
attcaccaat aaaaataaac tagagaaact tagtactaat aaggaactag aatcgtatag 18120
ttctagccct cttcaagaac ccattaggtt aaatgatttt ctgggactat tggaatgtgt 18180
taaaaagaat attcctctaa cagatattcc gacaaaggat tgattactat aaatggagaa 18240
tgttcctaat gtatacttta atcctgtgtt tatagagccc acgtttaaac attctttatt 18300
aagtgtttat aaacacagat taatagtttt atttgaagta ttcattgtat tcattctaat 18360
atatgtattt tttagatctg aattaaatat gttcttcatg cctaaacgaa aaatacccga 18420
tcctattgat agattacgac gtgctaatct agcgtgtgaa gacgataaat taatgatcta 18480
tggattacca tggatgacaa ctcaaacatc tgcgttatca ataaatagta aaccgatagt 18540
gtataaagat tgtgcaaagc ttttgcgatc aataaatgga tcacaaccag tatctcttaa 18600
cgatgttctt cgcagatgat gattcatttt ttaagtattt ggctagtcaa gatgatgaat 18660
cttcattatc tgatatattg caaatcactc aatatctaga ctttctgtta ttattattga 18720
tccaatcaaa aaataaatta gaagccgtgg gtcattgtta tgaatctctt tcagaggaat 18780
acagacaatt gacaaaattc acagactttc aagattttaa aaaactgttt aacaaggtcc 18840
ctattgttac agatggaagg gtcaaactta ataaaggata tttgttcgac tttgtgatta 18900
gtttgatgcg attcaaaaaa gaatcctctc tagctaccac cgcaatagat cctattagat 18960
acatagatcc tcgtcgcgat atcgcatttt ctaacgtgat ggatatatta aagtcgaata 19020
aagtgaacaa taattaattc tttattgtca tcatgaacgg cggacatatt cagttgataa 19080
tcggccccat gttttcaggt aaaagtacag aattaattag acgagttaga cgttatcaaa 19140
tagctcaata taaatgcgtg actataaaat attctaacga taatagatac ggaacgggac 19200
tatggacgca tgataagaat aattttgaag cattggaagc aactaaacta tgtgatgtct 19260
tggaatcaat tacagatttc tccgtgatag gtatcgatga aggacagttc tttccagaca 19320
ttgttgaatt ctgtgagcgt atggcaaacg aaggaaaaat agttatagta gccgcactcg 19380
atgggacatt tcaacgtaaa ccgtttaata atattttgaa tcttattcca ttatctgaaa 19440
tggtggtaaa actaactgct gtgtgtatga aatgctttaa ggaggcttcc ttttctaaac 19500
gattgggtga ggaaaccgag atagagataa taggaggtaa tgatatgtat caatcggtgt 19560
gtagaaagtg ttacgtcggc tcataatatt atatttttta tctaaaaaac taaaaataaa 19620
cattgattaa attttaatat aatacttaaa aatggatgtt gtgtcgttag ataaaccgtt 19680
tatgtatttt gaggaaattg ataatgagtt agattacgaa ccagaaagtg caaatgaggt 19740
cgcaaaaaaa ctgccgtatc aaggacagtt aaaactatta ctaggagaat tattttttct 19800
tagtaagtta cagcgacacg gtatattaga tggtgccacc gtagtgtata taggatctgc 19860
tcccggtaca catatacgtt atttgagaga tcatttctat aatttaggag tgatcatcaa 19920
atggatgcta attgacggcc gccatcatga tcctatttta aatggattgc gtgatgtgac 19980
tctagtgact cggttcgttg atgaggaata tctacgatcc atcaaaaaac aactgcatcc 20040
ttctaagatt attttaattt ctgatgtgag atccaaacga ggaggaaatg aacctagtac 20100
ggcggattta ctaagtaatt acgctctaca aaatgtcatg attagtattt taaaccccgt 20160
ggcgtctagt cttaaatgga gatgcccgtt tccagatcaa tggatcaagg acttttatat 20220
cccacacggt aataaaatgt tacaaccttt tgctccttca tattcagctg aaatgagatt 20280
attaagtatt tataccggtg agaacatgag actgactcga gttaccaaat cagacgctgt 20340
aaattatgaa aaaaagatgt actaccttaa taagatcgtc cgtaacaaag tagttgttaa 20400
ctttgattat cctaatcagg aatatgacta ttttcacatg tactttatgc tgaggaccgt 20460
gtactgcaat aaaacatttc ctactactaa agcaaaggta ctatttctac aacaatctat 20520
atttcgtttc ttaaatattc caacaacatc aactgaaaaa gttagtcatg aaccaataca 20580
acgtaaaata tctagcaaaa attctatgtc taaaaacaga aatagcaaga gatccgtacg 20640
cagtaataaa tagaaacgta ctactgagat atactaccga tatagagtat aatgatttag 20700
ttactttaat aaccgttaga cataaaattg attctatgaa aactgtgttt caggtattta 20760
acgaatcatc cataaattat actccggttg atgatgatta tggagaacca atcattataa 20820
catcgtatct tcaaaaaggt cataacaagt ttcctgtaaa ttttctatac atagatgtgg 20880
taatatctga cttatttcct agctttgtta gactagatac tacagaaact aatatagtta 20940
atagtgtact acaaacaggc gatggtaaaa agactcttcg tcttcccaaa atgttagaga 21000
cggaaatagt tgtcaagatt ctctaccgtc ctaatatacc attaaaaatt gttagatttt 21060
tccgcaataa catggtaact ggagtagaga tagccgatag atctgttatt tcagtcgctg 21120
attaatcaat tagtagagat gagataagaa cattataata atcaataata tattttatat 21180
cttatatctt gtttagaaaa atgctaatat taaaatagct aacgctagta atccaatcgg 21240
aagccatttg atatctataa tagggtatct aatttcctga ttcagatagc ggacagctat 21300
attctcggta gctactcgtt tggaatcaca aacattattt acatctaatt tactatctgt 21360
aatggaaacg tttcccaatg aaatggtaca atccgataca ttgcattttg ttatattttt 21420
ttttaaagag gctggtaaca acgcatcgct tcgtttacat ggctcgtacc aacaataata 21480
gggtaatctt gtatctattc ctatccgtac tatgctttta tcaggataaa tacatttaca 21540
tcgtatatcg tctttgttag catcacagaa tgcataaatt tgttcgtccg tcatgataaa 21600
aatttaaagt gtaaatataa ctattatttt atagttgtaa taaaaaggga aatttgattg 21660
tatactttcg gttctttaaa agaaactgac ttgataaaaa tggctgtaat ctctaaggtt 21720
acgtatagtc tatatgatca aaaagagatt aatgctacag atattatcat tagtcatgtt 21780
aaaaatgacg acgatatcgg taccgttaaa gatggtagac taggtgctat ggatggggca 21840
ttatgtaaaa cttgtgggaa aacggaattg gaatgtttcg gtcactgggg taaagtaagt 21900
atttataaaa ctcatatagt taagcctgaa tttatttcag aaattattcg tttactgaat 21960
tatatatgta ttcactgcgg attattgcgt tcacgagaac cgtattccga cgatattaac 22020
ctaaaagagt tatcgggaca cgctcttagg agattaaagg ataaaatatt atccaagaaa 22080
aagtcatgtt ggaacagtga atgtatgcaa ccgtatcaaa aaattacttt ttcaaagaaa 22140
aaggtttgtt tcgtcaacaa gttggatgat attaacgttc ctaattctct catctatcaa 22200
aagttaattt ctattcatga aaagttttgg ccattattag aaattcatca atatccagct 22260
aacttatttt atacagacta ctttcccatc cctccgttga ttattagacc ggctattagt 22320
ttttggatag atagtatacc caaagaaacc aatgaattaa cttacttatt aggtatgatc 22380
gttaagaatt gtaacttgaa tgctgatgaa caggttatcc agaaggcggt aatagaatac 22440
gatgatatta aaattatttc taataacact tccagtatca atttatcata tatcacatcc 22500
ggcaaaaata atatgattag aagttatatc gtcgcccggc gaaaagatca gaccgctaga 22560
tctgtaattg gtcccagtac atctatcacc gttaatgagg taggaatgcc cgcatatatt 22620
agaaatacac ttacagaaaa gatatttgtt aatgccttta cagtggataa agttaaacaa 22680
ctattagcgt caaaccaagt taaattttac tttaataaac gattaaacca attaacaaga 22740
atacgccaag gaaagtttat caaaaataaa atacatttat tgcctggtga ttgggtagaa 22800
gtagctgttc aagaatatac aagtattatt tttggaagac agccgtctct acatagatac 22860
aacgtcatcg cttcatctat cagagctacc gaaggagata ctatcaaaat atctcccgga 22920
attgtcaact ctcaaaatgc tgatttcgac ggagatgaag aatggatgat attggagcaa 22980
aatcctaaag ccgtaattga acaaagtatt cttatgtatc cgacgacgtt actcaaacac 23040
gatattcatg gagcccccgt ttatggatct attcaagatg aaatcgtagc agcgtattca 23100
ttgtttagga tacaagatct ttgtttagat gaagtattga acatcttggg gaaatatgga 23160
agagagttcg atcctaaagg taaatgtaaa ttcagcggta aagatatcta tacttacttg 23220
ataggtgaaa agattaatta tccgggtctc ttaaaggatg gtgaaattat tgcaaacgac 23280
gtagatagta attttgttgt ggctatgagg catctgtcat tggctggact cttatccgat 23340
cataagtcga acgtggaagg tatcaacttt attatcaagt catcttatgt ttttaagaga 23400
tatctatcta tttacggttt tggggtgaca ttcaaagatc tgagaccaaa ttcgacgttc 23460
actaataaat tggaggccat caacgtagaa aaaatagaac ttatcaaaga agcatacgcc 23520
aaatatctca acgatgtaag agacgggaaa atagttccat tatctaaagc tttagaggcg 23580
gactatgtgg aatccatgtt atccaacttg acaaatctta atatccgaga gatagaagaa 23640
catatgagac aaacgctgat agatgatcca gataataacc tcctgaaaat ggccaaagcg 23700
ggttataaag taaatcccac agaactaatg tatattctag gtacttatgg acaacagagg 23760
attgatggtg aaccagcaga gactcgagta ttgggtagag tcttacctta ctatcttcca 23820
gactctaagg atccagaagg aagaggttac attcttaatt ctttaacaaa aggattaacg 23880
ggttctcaat attacttttc gatgctggtt gcaagatctc aatctactga tatcgtctgt 23940
gaaacatcac gtaccggaac actggctaga aaaatcatta aaaagatgga ggatatggtg 24000
gtcgacggat acggacaagt agttataggt aatacgctca tcaagtacgc cgccaattat 24060
accaaaattc taggctcagt atgtaaacct gtagatctta tctatccaga tgagtccatg 24120
acttggtatt tggaaattag tgctctgtgg aataaaataa aacagggatt cgtttactct 24180
cagaaacaga aacttgcaaa aaagacattg gcgccgttta atttcctagt attcgtcaaa 24240
cccaccactg aggataatgc tattaaggtt aaggatctgt acgatatgat tcataacgtc 24300
attgatgatg tgagagagaa atacttcttt acggtatcta atatagattt tatggagtat 24360
atattcttga cgcatcttaa tccttctaga attagaatta caaaagaaac ggctatcact 24420
atctttgaaa agttctatga aaaactcaat tatactctag gtggtggaac tcctattgga 24480
attatttctg cacaggtatt gtctgagaag tttacacaac aagccctgtc cagttttcac 24540
actactgaaa aaagtggtgc cgtcaaacaa aaacttggtt tcaacgagtt taataacttg 24600
actaatttga gtaagaataa gaccgaaatt atcactctgg tatccgatga tatctctaaa 24660
cttcaatctg ttaagattaa tttcgaattt gtatgtttgg gagaattaaa tccaaacatc 24720
actcttcgaa aagaaacaga taggtatgta gtagatataa tagtcaatag attatacatc 24780
aagagagcag aaattaccga attagtcgtc gaatatatga ttgaacgatt catctccttt 24840
agcgtcattg taaaggaatg gggtatggaa acattcattg aggatgagga taatattaga 24900
tttactgtct acctaaattt cgttgaaccg gaagaattga atcttagtaa gtttatgatg 24960
gttcttccgg gtgccgccaa caagggcaag attagtaaat tcaagattcc tatctctgat 25020
tatacgggat atgacgactt caatcaaaca aaaaagctca ataagatgac tgtagaactc 25080
atgaatctaa aagaattggg ttctttcgat ttggaaaacg tcaacgtgta tcctggagta 25140
tggaatacat acgatatctt cggtatcgag gccgctcgtg aatacttgtg cgaagccatg 25200
ttaaacacct atggagaagg gttcgattat ctgtatcagc cttgtgatct tctcgctagt 25260
ttactatgtg ctagttacga accagaatca gtgaataaat tcaagttcgg cgcagctagt 25320
actcttaaga gagctacgtt cggagacaat aaagcattgt taaacgcggc tcttcataaa 25380
aagtcagaac ctattaacga taatagtagc tgccactttt ttagcaaggt ccctaatata 25440
ggaactggat attacaaata ctttatcgac ttgggtcttc tcatgagaat ggaaaggaaa 25500
ctatctgata agatatcttc tcaaaagatc aaggaaatgg aagaaacaga agacttttaa 25560
ttcttatcaa taacatattt ttctatgatc tgtcttttaa acgatggatt ttccacaaat 25620
gcgcctctca agtccctcat agaatgatac acgtataaaa aatatagcat aggcaatgac 25680
tccttatttt tagacattag atatgccaaa atcatagccc cgcttctatt tactcccgca 25740
gcacaatgaa ccaacacggg ctcgtttcgt tgatcacatt tagataaaaa ggcggttacg 25800
tcgtcaaaat atttactaat atcggtagtt gtatcatcta ccaacggtat atgaataata 25860
ttaatattag agttaggtaa tgtatattta tccatcgtca aatttaaaac atatttgaac 25920
ttaacttcag atgatggtgc atccatagca tttttataat ttcccaaata cacattattg 25980
gttactcttg tcattatagt gggagatttg gctttgtgca tatctccagt tgaacgtagt 26040
agtaagtatt tatacaaact tttcttatcc atttataacg tacaaatgga taaaactact 26100
ttatcggtaa acgcgtgtaa tttagaatac gttagagaaa aggctatagt aggcgtacaa 26160
gcagccaaaa catcaacact tatattcttt gttattatat tggcaattag tgcgctatta 26220
ctctggtttc agacgtctga taatccagtc tttaatgaat taacgagata tatgcgaatt 26280
aaaaatacgg ttaacgattg gaaatcatta acggatagca aaacaaaatt agaaagtgat 26340
agaggtagac ttctagccgc tggtaaggat gatatattcg aattcaaatg tgtggatttc 26400
ggcgcctatt ttatagctat gcgattggat aagaaaacat atctgccgca agctattagg 26460
cgaggtactg gagacgcgtg gatggttaaa aaggcggcaa aggtcgatcc atctgctcaa 26520
caattttgtc agtatttgat aaaacacaag tctaataatg ttattacttg tggtaatgag 26580
atgttaaatg aattaggtta tagcggttat tttatgtcac cgcattggtg ttccgatttt 26640
agtaatatgg aatagtgtta gataaatgcg gtaacgaatg ttcctgtaag gaaccataac 26700
agcttagatt taacgttaaa gatgagcata aacataataa acaaaattac aatcaaacct 26760
ataacattaa tatcaaacaa tccaaaaaat gaaatcagtg gagtagtaaa cgcgtacata 26820
actcctggat aacgtttagc agctgccgtt cctattctag accaaaaatt cggtttcatg 26880
ttttcgaaac ggtattctgc aacaagtcga ggatcgtgtt ctacatattt ggcggcgtta 26940
tccagtatct gcctattgat cttcatttcg ttttcgattc tggctatttc aaaataaaat 27000
cccgatgata gacctccaga ctttataatt tcatctacga tgttcagcgc cgtagtaact 27060
ctaataatat aggctgataa gctaacatca taccctcctg tatatgtgaa tatggcatga 27120
tttttgtcca ttacaagctc ggttttaact ttattgcctg taataatttc tctcatctgt 27180
aggatatcta tttttttgtc atgcattgcc ttcaagacgg gacgaagaaa cgtaatatcc 27240
tcaataacgt tatcgttttc tacaataact acatattcta cctttttatt ttctaactcg 27300
gtaaaaaaat tagaatccca tagggctaaa tgtctagcga tatttctttt cgtttcctct 27360
gtacacatag tgttacaaaa ccctgaaaag aagtgagtat acttgtcatc atttctaatg 27420
tttcctccag tccactgtat aaacgcataa tccttgtaat gatctggatc atccttgact 27480
accacaacat ttcttttttc tggcataact tcattgtcct ttacatcatc gaacttctga 27540
tcattaatat gctcatgaac attaggaaat gtttctgatg gaggtctatc aataactggc 27600
acaacaataa caggagtttt caccgccgcc atttagttat tgaaattaat catatacaac 27660
tctttaatac gagttatatt ttcgtctatc cattgtttca catttacata tttcgacaaa 27720
aagatataaa atgcgtattc caatgcttct ctgtttaatg aattactaaa atatacaaac 27780
acgtcactgt ctggcaataa atgatatctt agaatattgt aacaatttat tttgtattgc 27840
acatgttcgt gatctatgag ttcttcttcg aatggcatag gatctccgaa tctgaaaacg 27900
tataaatagg agttagaata ataatatttg agagtattgg taatatataa actctttagc 27960
ggtataatta gtttttttct ctcgatttct atttttagat gtgatggaaa aatgactaat 28020
tttgtagcat tagtatcatg aactctaatc gagatcttaa tatcttcgtc acacgttagt 28080
tctttgaagt ttttaagaga tgcatcagtt ggttcgaccg atggagtagg tgcaacaatt 28140
ttttgttcga tgtatgtatg tactggagcc attgtcttaa ctataatggt gcttgtatcg 28200
aaaaacttta atgcagataa tggaagctct tcgccgcgac tttctacatc gtaattgggt 28260
tctaacgccg atctctgaat ggatactagt tttctaagtt ctaatgtgat tctctgaaaa 28320
tgtaaatcca attcctccgg cattatagat gtgtatacat cggtaaataa aactatagta 28380
tccaacgatc ccttctcgca aattctagtc ttaaccaaaa aatcgtatat aaccacggag 28440
atggcgtatt taagagtgga ttcttctacc gttttgttct tggatttcat ataagaaact 28500
ataaagtccg cactactgtt aagaatgatt actaacgcaa ctatatagtt taaattaagc 28560
atcttggaaa cataaaataa ctctgtagac gatacttgac tttcgaataa gtttgcagac 28620
aaacgaagaa agaacagacc tctcttaatt tcagaagaaa actttttttc gtattcctga 28680
cgtctagagt ttatatcaat aagaaagtta agaattagtc ggttaatgtt gtatttcatt 28740
acccaagttt gagatttcat aatattatca aaagacatga taatattaaa gataaagcgc 28800
tgactatgaa cgaaatagct atatggttcg ctcaagaata tagtcttgtt aaacgtggaa 28860
acgataactg tatttttaat cacgtcagcg gcatctaaat taaatatagg tatatttatt 28920
ccacacactc tacaatatgc cacaccatct tcataataaa taaattcgtt agcaaaatta 28980
ttaattttag tgaaatagtt agcgtcaact ttcatagctt ccttcaatct aatttgatgc 29040
tcacacggtg cgaattccac tctaacatcc cttttccatg cctcaggttc atcgatctct 29100
ataatatcta gttttttgcg tttcacaaac acaggctcgt ctctcgcgat gagatctgta 29160
tagtaactat gtaaatgata actagataga aagatgtagc tatatagatg acgatccttt 29220
aagagaggta tgatgacttt accccaatca gatagactgt tgttatggtc ttcggaaaaa 29280
gaatttttat aaatttttcc agtattttcc aaatatacgt acttaacatc taaaaaatcc 29340
ttaatgataa taggaatgga taatccgtct attttataaa gaaatacata tcgcacatta 29400
tacttttttt tggaaatggg aataccgatg tgtctacata aatatgcaaa gtctaaatat 29460
tttttagaga atcttagttg gtccaaattc ttttccaagt acggtaatag atttttcata 29520
ttgaacggta tcttcttaat ctctggttct agttccgcat taaatgatga aactaagtca 29580
ctatttttat aactaacgat tacatcacct ctaacatcat catttaccag aatactgatc 29640
ttcttttgtc gtaaatacat gtctaatgtg ttaaaaaaaa gatcatacaa gttatacgtc 29700
atttcatctg tggtattctt gtcattgaag gataaactcg tactaatctc ttctttaaca 29760
gcctgttcaa atttatatcc tatatacgaa aaaatagcaa ccagtgtttg atcatccgcg 29820
tcaatattct gttctatcgt agtgtataac aatcgtatat cttcttctgt gatagtcgat 29880
acgttataaa ggttgataac gaaaatattt ttatttcgtg agataaagtc atcgtaggat 29940
tttggactta tattcgcgtc tagtagatat gcttttattt ttggaatgat ctcaattaga 30000
atagtctctt tagagtccat ttaaagttac aaacaactag gaaattggtt tatgatgtat 30060
aattttttta gtttttatag attctttatt ctatacttaa aaaatgaaaa taaatacaaa 30120
ggttcttgag ggttgtgtta aattgaaagc gagaaataat cataaattat ttcattatcg 30180
cgatatccgt taagtttgta tcgtaatggc gtggtcaatt acaaataaag cggatactag 30240
tagcttcaca aagatggctg aaatcagagc tcatctaaaa aatagcgctg aaaataaaga 30300
taaaaacgag gatattttcc cggaagatgt aataattcca tctactaagc ccaaaaccaa 30360
acgagccact actcctcgta aaccagcggc tactaaaaga tcaaccaaaa aggaggaagt 30420
ggaagaagaa gtagttatag aggaatatca tcaaacaact gaaaaaaatt ctccatctcc 30480
tggagtcagc gacattgtag aaagcgtggc tgctgtagag ctcgatgata gcgacgggga 30540
tgatgaacct atggtacaag ttgaagctgg taaagtaaat catagtgcta gaagcgatct 30600
ttctgaccta aaggtggcta ccgacaatat cgttaaagat cttaagaaaa ttattactag 30660
aatctctgca gtatcgacgg ttctagagga tgttcaagca gctggtatct ctagacaatt 30720
tacttctatg actaaagcta ttacaacact atctgatcta gtcaccgagg gaaaatctaa 30780
agttgttcgt aaaaaagtta aaacttgtaa gaagtaaatg cgtgcacttt tttataaaga 30840
tggtaaactc tttaccgata ataatttttt aaatcctgta tcagacgata atccagcgta 30900
tgaggttttg caacatgtta aaattcctac tcatttaaca gatgtagtag tatatgaaca 30960
aacgtgggag gaggcgttaa ctagattaat ttttgtggga agtgattcaa aaggacgtag 31020
acaatacttt tacggaaaaa tgcatgtaca gaatcgcaac gctaaaagag atcgtatttt 31080
tgttagagta tataacgtta tgaaacgaat taattgtttt ataaacaaaa atataaagaa 31140
atcgtccaca gattccaatt atcagttggc ggtttttatg ttaatggaaa ctatgttttt 31200
tattagattt ggtaaaatga aatatcttaa ggagaatgaa acagtagggt tattaacact 31260
aaaaaataaa cacatagaaa taagtcccga tgaaatagtt atcaagtttg taggaaagga 31320
caaagtttca catgaatttg ttgttcataa gtctaataga ctatataaac cgctattgaa 31380
actgacggat gattctagtc ccgaagaatt tctgttcaac aaactaagtg aacgaaaggt 31440
atacgaatgt atcaaacagt ttggtattag aatcaaggat ctccgaacgt atggagtcaa 31500
ttatacgttt ttatataatt tttggacaaa tgtaaagtcc atatctcctc ttccgtcacc 31560
aaaaaagtta atagcgttaa ctatcaaaca aactgctgaa gtggtaggtc atactccatc 31620
aatttcaaaa agagcttata tggcaacgac tattttagaa atggtaaagg ataaaaattt 31680
tttagatgta gtatctaaaa ctacgttcga tgaattccta tctatagtcg tagatcacgt 31740
taaatcatct acggatggat gatatagatc tttacacaaa taattacaag accgataaat 31800
ggaaatggat aagcgtatga aatctctcgc aatgacagct ttcttcggag agctaaacac 31860
attagatatt atggcattga taatgtctat atttaaacgc catccaaaca ataccatttt 31920
ttcagtggat aaggatggtc agtttatgat tgatttcgaa tacgataatt ataaggcttc 31980
tcaatatttg gatctgaccc tcactccgat atctggagat gaatgcaaga ctcacgcatc 32040
gagtatagcc gaacaattgg cgtgtgtgga tattattaaa gaggatatta gcgaatatat 32100
caaaactact ccccgtctta aacgatttat aaaaaaatac cgcaatagat cagatactcg 32160
tatcagtcga gatacagaaa agcttaaaat agctctagct aaaggcatag attacgaata 32220
tataaaagac gcttgttaat aagtaaatga aaaaaaacta gtcgtttata ataaaacaca 32280
atatggatgc caacatagta tcatcttcta ctattgcaac gtatatagac gctttagcga 32340
agaatgcttc agaattagaa cagaggtcta ccgcatacga aataaataat gaattggaac 32400
tagtatttat taagccgcca ttaattactt tgacaaatgt agtgaatatc tctacgattc 32460
aggaatcgtt tattcgattt accgttacta ataaggaagg tgttaaaatt agaactaaga 32520
ttccattatc taaggtacat ggtctagatg taaaaaatgt acagttagta gatgctatag 32580
ataacatagt ttgggaaaag aaatcattag tgacggaaaa tcgtcttcac aaagaatgct 32640
tgttgagact atcgacagag gaacgtcata tatttttgga ttacaagaaa tatggatcct 32700
ctatccgact agaattagtc aatcttattc aagcaaaaac aaaaaacttt acgatagact 32760
ttaagctaaa atattttcta ggatccggtg cccagtctaa aagttcttta ttacacgcta 32820
ttaatcatcc aaagtcaagg cctaatacat ctctggaaat agaattcaca cctagagaca 32880
atgaaaaagt tccatatgat gaactaataa aggaattgac gactctatca cgtcatatat 32940
ttatggcttc tccagagaat gtaattcttt ctccgcctat taacgcgcct ataaaaacct 33000
ttatgttgcc taaacaagat atagtaggtt tggatctgga aaatctatat gccgtaacta 33060
agactgacgg aattcctata actatcagag ttacatcaaa agggttgtat tgttatttta 33120
cacatcttgg ttatattatt agatatcctg ttaagagaat aatagattcc gaagtagtag 33180
tctttggtga ggcagttaag gataagaact ggaccgtata tctcattaag ctaatagagc 33240
ctgtgaatgc aatcaatgat agactagaag aaagtaagta tgttgaatct aaactagtgg 33300
atatttgtga tcggatagta ttcaagtcaa agaaatacga aggtccgttt actacaacta 33360
gtgaagtcgt cgatatgtta tctacatatt taccaaagca accagaaggt gttattctgt 33420
tctattcaaa gggacctaaa tctaacattg attttaaaat taaaaaggaa aatactatag 33480
accaaactgc aaatgtagta tttaggtaca tgtccagtga accaattatc tttggagaat 33540
cgtctatctt tgtagagtat aagaaattta gcaacgataa aggctttcct aaagaatatg 33600
gttctggtaa gattgtgtta tataacggcg ttaattatct aaataatatc tattgtttgg 33660
aatatattaa tacacataat gaagtgggta ttaagtccgt ggttgtacct attaagttta 33720
tagcagaatt cttagttaat ggagaaatac ttaaacctag aattgataaa accatgaaat 33780
atattaactc agaagattat tatggaaatc aacataatat catagtcgaa catttaagag 33840
atcaaagcat caaaatagga gatatcttta acgaggataa actatcggat gtgggacatc 33900
aatacgccaa taatgataaa tttagattaa atccagaagt tagttatttt acgaataaac 33960
gaactagagg accgttggga attttatcaa actacgtcaa gactcttctt atttctatgt 34020
attgttccaa aacattttta gacgattcca acaaacgaaa ggtattggcg attgattttg 34080
gaaacggtgc ggacctggaa aaatactttt atggagagat tgcgttattg gtagcgacgg 34140
atccggatgc tgatgctata gctagaggaa atgaaagata caacaaatta aactctggaa 34200
ttaaaaccaa gtactacaaa tttgactaca ttcaggaaac tattcgatcc gatacatttg 34260
tctctagtgt cagagaagta ttctattttg gaaagtttaa tatcatcgac tggcagtttg 34320
ctatccatta ttcttttcat ccgagacatt atgctaccgt catgaataac ttatccgaac 34380
taactgcttc tggaggcaag gtattaatca ctaccatgga cggagacaaa ttatcaaaat 34440
taacagataa aaagactttt ataattcata agaatttacc tagtagcgaa aactatatgt 34500
ctgtagaaaa aatagctgat gatagaatag tggtatataa tccatcaaca atgtctactc 34560
caatgactga atacattatc aaaaagaacg atatagtcag agtgtttaac gaatacggat 34620
ttgttcttgt agataacgtt gatttcgcta caattataga acgaagtaaa aagtttatta 34680
atggcgcatc tacaatggaa gatagaccgt ctacaaaaaa ctttttcgaa ctaaatagag 34740
gagccattaa atgtgaaggt ttagatgtcg aagacttact tagttactat gttgtttatg 34800
tcttttctaa gcggtaaata ataatatggt atgggttctg atatccccgt tctaaatgca 34860
ttaaataatt ccaatagagc gatttttgtt cctataggac cttccaactg tggatactct 34920
gtattgttaa tagatatatt aatacttttg tcgggtaaca gaggttctac gtcttctaaa 34980
aataaaagtt tgataacatc tggcctgttc ataaataaaa acttggcgat tctatatata 35040
ctcttattat caaatctagc cattgtctta tagatgtgag ctactgtagg tgtaccattt 35100
gattttcttt ctaatactat atatttctct cgaagaagtt cttgcacatc atctgggaat 35160
aaaatactac tgttgagtaa atcagttatt ttttttatat cgatattgat ggacattttt 35220
atagttaagg ataataagta tcccaaagtc gataacgacg ataacgaagt atttatactt 35280
ttaggaaatc acaatgactt tatcagatca aaattaacaa aattaaagga gcatgtattt 35340
ttttctgaat atattgtgac tccagataca tatggatctt tatgcgtcga attaaatggg 35400
tctagttttc agcacggtgg tagatatata gaggtggagg aatttataga tgctggaaga 35460
caagttagat ggtgttctac atccaatcat atatctgaag atatgcacac tgataaattt 35520
gtcatttatg atatttatac gtttgattcg ttcaagaata aacgattggt atttgtacag 35580
gtgcctccat cattaggaga tgatagctat ttgactaatc cgttattgtc tccgtattat 35640
cgtaattcag tagccagaca aatggtcaat gatatgattt ttaatcaaga ttcattttta 35700
aaatatttat tagaacatct gattagaagc cactatagag tttctaaaca tataacaata 35760
gttagataca aggataccga agaattaaat ctaacgagaa tatgttataa tagagataag 35820
tttaaggcgt ttgtattcgc ttggtttaac ggcgtttcgg aaaatgaaaa ggtactagat 35880
acgtataaaa aggtatctaa tttgatataa tgaattcagt gactgtatca cacgcgccat 35940
atactattac ttatcacgat gattgggaac cagtaatgag tcaattggta gagttttata 36000
acgaagtagc cagttggctg ctacgagacg agacgtcgcc tattcctgat aagttcttta 36060
tacagttgaa acaaccgctt agaaataaac gagtatgtgt gtgtggtata gatccgtatc 36120
cgaaagatgg aactggtgta ccgttcgaat caccaaattt tacaaaaaaa tcaattaagg 36180
agatagcttc atctatatct agattaaccg gagtaattga ttataaaggt tataacctta 36240
atataataga cggggttata ccctggaatt attacttaag ttgtaaatta ggagaaacaa 36300
aaagtcacgc gatctactgg gataagattt ccaagttact gctgcagcat ataactaaac 36360
acgttagtgt tctttattgt ttgggtaaaa cagatttctc gaatatacgg gcaaagttag 36420
aatccccggt aactaccata gtcggatatc atccagcggc tagagaccgc caattcgaga 36480
aagatagatc atttgaaatt atcaacgttt tactggaatt agacaacaag gcacctataa 36540
attgggctca agggtttatt tattaatgct ttagtgaaat tttaacttgt gttctaaatg 36600
gatgcaacta ttagaggtaa tgatgttatc tttgttctta agactatagg tgtcccgtca 36660
gcgtgcagac aaaatgaaga tccaagattt gtagaagcat ttaaatgcga cgagttagaa 36720
agatatattg agaataatcc agaatgtaca ctattcgaaa gtcttaggga tgaggaagca 36780
tactctatag tcagaatttt catggatgta gatttagacg cgtgtctaga cgaaatagat 36840
tatttaacgg ctattcaaga ttttattatc gaggtgtcaa actgtgtagc tagattcgcg 36900
tttacagaat gcggtgccat tcatgaaaat gtaataaaat ccatgagatc taatttttca 36960
ttgactaagt ctacaaatag agataaaaca agttttcata ttatcttttt agacacgtat 37020
accactatgg atacattgat agctatgaaa cgaacactat tagaattaag tagatcatct 37080
gaaaatccac taaccagatc gatagacact gccgtatata ggagaaaaac aactcttcgg 37140
gttgtaggta ctaggaaaaa tccaaattgc gacactattc atgtaatgca accaccgcat 37200
gataatatag aagattacct attcacttac gtggatatga acaacaatag ttattacttt 37260
tctctacaac gacgattgga ggatttagtt cctgataagt tatgggaacc agggtttatt 37320
tcattcgaag acgctataaa aagagtttca aaaatattca ttaattctat aataaacttt 37380
aatgatctcg atgaaaataa ttttacaacg gtaccactgg tcatagatta cgtaacacct 37440
tgtgcattat gtaaaaaacg atcgcataaa catccgcatc aactatcgtt ggaaaatggt 37500
gctattagaa tttacaaaac tggtaatcca catagttgta aagttaaaat tgttccgttg 37560
gatggtaata aactgtttaa tattgcacaa agaattttag acactaactc tgttttatta 37620
accgaacgag gagaccatat agtttggatt aataattcat ggaaatttaa cagcgaagaa 37680
cccttgataa caaaactaat tctgtcaata agacatcaac tacctaagga atattcaagc 37740
gaattactct gtccgaggaa acgaaagact gtagaagcta acatacgaga catgttaata 37800
gattcagtgg agaccgatac ctatccggat aaacttccgt ttaaaaatgg tgtattggac 37860
ctggtagacg gaatgtttta ctctggagat gatgctaaaa aatatacgtg tactgtatca 37920
accggattta aatttgacga tacaaagttc gtcgaagaca gtccagaaat ggaagagtta 37980
atgaatatca ttaacgatat ccaaccatta acggatgaaa ataagaaaaa tagagagttg 38040
tacgaaaaaa ctttatctag ttgtttatgc ggtgctacca aaggatgttt aacattcttt 38100
tttggagaaa ctgcaactgg aaagtcgaca accaaacgtt tgttaaagtc tgctatcggt 38160
gacctgtttg ttgagacggg tcaaacaatt ttaacagatg tattggataa aggacctaat 38220
ccatttatcg ctaacatgca tttgaaaaga tctgtattct gtagcgaact acctgatttt 38280
gcctgtagtg gatcaaagaa aattagatct gacaatatta aaaagttgac agaaccttgt 38340
gtcattggaa gaccgtgttt ctccaataaa attaataata gaaaccatgc gacaatcatt 38400
atcgatacta attacaaacc tgtctttgat aggatagata acgcattaat gagaagaatt 38460
gccgtcgtgc gattcagaac acacttttct caaccttctg gtagagaggc tgctgaaaat 38520
aatgacgcgt acgataaagt caaactatta gacgaggggt tagatggtaa aatacaaaat 38580
aatagatata gattcgcatt tctatacttg ttggtgaaat ggtacaaaaa atatcatgtt 38640
cctattatga aactatatcc tacaccggaa gagattccgg actttgcatt ctatctcaaa 38700
ataggtactc tgttagtatc tagctctgta aagcatattc cattaatgac ggacctctcc 38760
aaaaagggat atatattgta cgataatgtg gttactcttc cgttgactac tttccaacag 38820
aaaatatcca agtattttaa ttctagacta tttggacacg atatagagag cttcatcaat 38880
agacataaga aatttgccaa tgttagtgat gaatatctgc aatatatatt catagaggat 38940
atttcatctc cgtaaatata tgctcatata tttatagaag atatcacata tctaaatgaa 39000
taccggaatc atagatttat ttgataatca tgttgatagt ataccaacta tattacctca 39060
tcagttagct actctagatt atctagttag aactatcata gatgagaaca gaagcgtgtt 39120
attgttccat attatgggat caggtaaaac aataatcgct ttgttgttcg ccttggtagc 39180
ttccagattt aaaaaggttt acattctagt gcctaatatt aacattttga aaatttttaa 39240
ttataatatg ggtgtagcta tgaacttgtt taatgacgaa ttcatagctg agaatatctt 39300
tattcattcc acaacaagtt tttattctct taattataac gataacgtca ttaattataa 39360
cggattatct cgctacaata actctatttt tatcgttgat gaggcacata atatctttgg 39420
gaataatact ggagaactta tgaccgtgat aaaaaataaa aacaagattc cttttttact 39480
attgtctgga tctcccatta ctaacacacc taatactctg ggtcatatta tagatttaat 39540
gtccgaagag acgatagatt ttggtgaaat tattagtcgt ggtaagaaag taattcagac 39600
acttcttaac gaacgaggtg tgaatgtact taaggatttg cttaaaggaa gaatatcata 39660
ttacgaaatg cctgataaag atctaccaac gataagatat cacggacgta agtttctaga 39720
tactagagta gtatattgtc acatgtctaa acttcaagag agagattata tgattactag 39780
acgacagcta tgttatcatg aaatgtttga taaaaatatg tataacgtgt caatggcagt 39840
attgggacaa cttaatctga tgaataattt agatacttta tttcaggaac aggataagga 39900
attgtaccca aatctgaaaa taaataatgg cgtgttatac ggagaagaat tggtaacgtt 39960
aaacattagt tccaaattta aatactttat taatcggata cagacactca acggaaaaca 40020
ttttatatac ttttctaatt ctacatatgg cggattggta attaaatata tcatgctcag 40080
taatggatat tctgaatata atggttctca gggaactaat ccacatatga taaacggcaa 40140
accaaaaaca tttgctatcg ttactagtaa aatgaaatcg tctttagagg atctattaga 40200
tgtgtataat tctcctgaaa acgatgatgg cagtcaattg atgtttttgt tttcgtcaaa 40260
cattatgtcc gaatcctata ctctgaaaga ggtaaggcat atttggttta tgactatccc 40320
agatactttt tctcaataca accaaattct tggacgatct attagaaaat tctcttacgc 40380
cgatatttct gaaccagtta atgtatatct tttagccgcc gtatattccg atttcaatga 40440
cgaagtgacg tcattaaacg attacacaca ggatgaatta attaatgttt taccatttga 40500
catcaaaaag ctgttgtatc taaaatttaa gactaaagaa acgaatagaa tatactctat 40560
tcttcaagag atgtctgaaa cgtattctct tccaccacat ccatcaattg taaaagtttt 40620
attgggagaa ttggtcagac aattttttta taataattct cgtattaagt ataacgatac 40680
caagttactt aaaatggtta catcagttat aaaaaataaa gaagacgcta ggaattacat 40740
agatgatatt gtaaacggtc acttctttgt atcgaataaa gtatttgata aatctctttt 40800
atacaaatac gaaaacgata ttattacagt accgtttaga ctttcctacg aaccatttgt 40860
ttggggagtt aactttcgta aagaatataa cgtggtatct tctccataaa actgatgaga 40920
tatataaaga aataaatgtc gagctttgtt accaatggat accttccagt tacattggag 40980
ccacacgagc tgacgttaga cataaaaact aatattagga atgccgtata taagacgtat 41040
ctccatagag aaattagtgg taaaatggcc aagaaaatag aaattcgtga agacgtggaa 41100
ttacctctcg gcgaaatagt taataattct gtagttataa acgttccgtg tgtaataacc 41160
tacgcgtatt atcacgttgg ggatatagtc agaggaacat taaacatcga agatgaatca 41220
aatgtaacta ttcaatgtgg agatttaatc tgtaaactaa gtagagattc gggtactgta 41280
tcatttagcg attcaaagta ctgctttttt cgaaatggta atgcgtatga caatggcagc 41340
gaagtcactg ccgttctaat ggaggctcaa caaggtatcg aatctagttt tgtttttctc 41400
gcgaatatcg ttgactcata aaaaagagaa tagcggtaag tataaacacg aatactatgg 41460
caataattgc gaatgtttta ttcccttcga tatatttttg ataatatgaa aaacatgtct 41520
ctctcaaatc ggacaaccat ctcataaaat agttctcgcg cgctggagag gtagttgctg 41580
ctcgtataat ctccccagaa taatatactt gcgtgtcgtc gttcaattta tacggatttc 41640
tatagttctc tgttatataa tgcggttttc catcatgatt agacgacgac aatagtgttc 41700
taaatttaga tagttgatca gaatgaatgt ttattggcgt tggaaaaatt atccatacag 41760
cgtctgcaga gtggttgata gttgttccta gatatgtaaa ataatccaac ttactaggca 41820
gcaaattgtc tagataaaat actgaatcaa acggtgcaga cgtattggtg gatctaatgg 41880
aatccaattg attaactatc ttttgaaaat atacattttt atgatccgat acttgtaaga 41940
atatagaaat aatgataagt ccatcatcgt gtttttttgc ctcttcataa gaactatatt 42000
ttttcttatt ccaatgaaca agattaatct ctccagagta tttgtacaca tctatcaagt 42060
gattggatcc ataatcgtct tcctttcccc aatatatacg tagtgatgat aacacatatt 42120
cattggggag aaaccctcca cttatatatc ctcctttaaa attaatcctt actagttttc 42180
cagtgttctg gatagtggtt ggtttcgact cattataatg tatgtctaac ggcttcaatc 42240
gcgcgttaga aattgctttt ttagtttcta tattaatagg agatagttgt tgcggcatag 42300
taaaaatgaa atgataactg tttaaaaata gctcttagta tgggaattac aatggatgag 42360
gaagtgatat ttgaaactcc tagagaatta atatctatta aacgaataaa agatattcca 42420
agatcaaaag acacgcatgt gtttgctgcg tgtataacaa gtgacggata tccgttaata 42480
ggagctagaa gaacttcatt cgcattccaa gcgatattat ctcaacaaaa ttcagattct 42540
atctttagag tatccactaa actattacgg tttatgtact acaatgaact aagagaaatc 42600
tttagacggt tgagaaaagg ttctatcaac gatatcgatc ctcactttga agagttaata 42660
ttattgggtg gtaaactaga taaaaaggaa tctattaaag attgtttaag aagagaatta 42720
aaagaggaaa gtgatgaacg tataacagta aaagaatttg gaaatgtaat tctaaaactt 42780
acaacacggg ataaattatt taataaagta tatataagtt attgcatggc gtgttttatt 42840
aatcaatcgt tggaggattt atcgcatact agtatttaca atgtagaaat tagaaagatt 42900
aaatcattaa atgattgtat taacgacgat aaatacgaat atctgtctta tatttataat 42960
atgctagtta atagtaaatg aacttttaca gatctagtat aattagtcag attattaagt 43020
ataatagacg actagctaag tctattattt gcgaggatga ctctcaaatt attacactca 43080
cggcattcgt taaccaatgc ctatggtgtc ataaacgagt atccgtgtcc gctattttat 43140
taactactga taacaaaata ttagtatgta acagacgaga tagttttctc tattctgaaa 43200
taattagaac tagaaacatg tctagaaaga aacgattatt tctgaattat tccaattatt 43260
tgtccaaaca ggaaagaagt atactatcgt catttttttc tctagatcca gctactactg 43320
ataatgatag aatagatgct atttatccgg gtggcatacc caaaaggggt gagaatgttc 43380
cagagtgttt atccagggaa attaaagaag aagttaatat agacaattct tttgtattca 43440
tagacactcg gttttttatt catggcatca tagaagatac cattattaat aaattttttg 43500
aggtaatctt ctttgtcgga agaatatctt taacgagtga tcaaatcatt gatacattta 43560
aaagtaatca tgaaatcaag gatctaatat ttttagatcc gaattcaggt aatggactcc 43620
aatacgaaat tgcaaaatat gctctagata ctgcaaaact caaatgttat ggccatagag 43680
gatgttatta cgaatcatta aaaaaattaa ctgaggatga ttgattagaa aatataaatt 43740
aatttaccat cgtgtatttt tataacggga ttgtccggca tatcatgtag atagttaccg 43800
tctacatcgt atactcgacc atctacgcct ttaaatcctc tatttattga cattaatcta 43860
ttagaattgg aataccaaat attagtaccc tcaattagtt tattggtaat atttttttta 43920
gacgatagat cgatggctct tgaaaccaag gttttccaac cggactcatt gtcgatcggt 43980
gagaagtctt tttcattagc atgaatccat tctaatgatg tatgtttaaa cactctaaac 44040
aattggacaa attcttttga tttgctttga atgatttcaa ataggtcttc gtctacagta 44100
ggcataccat tagataatct agccattata aagtgcacgt ttacatatct acgttctgga 44160
ggagtaagaa cgtgactatt gagacgaatg gctcttccta ctatctgacg aagagacgcc 44220
tcgttccatg tcatatctaa aatgaagata tcattaattg agaaaaaact aataccctcg 44280
cctccactag aagagaatac gcatgtttta atgcattctc cgttagtgtt tgattcttgg 44340
ttaaactcag ccaccgcctt gattctagta tcttttgttc tagatgagaa ctctatatta 44400
gagataccaa agactttgaa atatagtaat aagatttcta ttcctgactg attaacaaat 44460
ggttcaaaga ctagacattt accatgggat gctaatattc ccaaacatac atctataaat 44520
ttgacgcttt tctcttttaa ttcagtaaat agagagatat cagccgcact agcatcccct 44580
ttcaatagtt ctcccttttt aaaggtatct aatgcggatt tagaaaactc tctatctctt 44640
aatgaatttt taaaatcatt atatagtgtt gctatctctt gcgcgtattc gcccggatca 44700
cgattttgtc tttcaggaaa gctatcgaac gtaaacgtag tagccatacg tctcagaatt 44760
ctaaatgatg atatacctgt ttttatttca gcgagtttag ccttttgata aatttcttct 44820
tgctttttcg acatattaac gtatcgcatt aatactgttt tcttagcgaa tgatgcagac 44880
ccttctacgt catcaaaaat agaaaactcg ttattaacta tgtacgaaca taggcctcct 44940
agtttggaga ctaattcttt ctcatcaact agacgtttat tctcaaatag cgattggtgt 45000
tgtaaggatc ctggtcgtag taagttaacc aacatggtga attcttgcac actattaacg 45060
ataggtgtag ccgataaaca aatcatctta tggtttttta atgcgatggt cttagataaa 45120
aaattatata ctgaacgagt aggacggatc ttaccatctt ctttgattaa tgatttagaa 45180
atgaagttat gacattcatc aataatgacg catattctac tcttggaatt aatagttttg 45240
atattagtaa aaaatttatt tctaaaattt tgatcatcgt aattaataaa aatacaatcc 45300
ttcgttatct ctggagcgta tctgagtata gtgttcatcc aaggatcttc tatcaaagcc 45360
tttttcacca ataagataat agcccaattc gtataaatat ccttaagatg tttgagaata 45420
tatacagtag tcattgtttt accaacaccc gtttcatgga acaataaaag agaatgcata 45480
ctgtctaatc ctaagaaaac tcttgctaca aaatgttgat aatccttgag gcgtactacg 45540
tctgttccca tcatttcaac aggcatatta gtagttctgc gcaatgcata atcgatatag 45600
gccgcgtgtg atttactcat ttatgagtga taagtaataa ctatgtttta aaaatcacag 45660
cagtagttta actagtcttc tctgatgttt gttttcgata ctttttgaat cagaagtcat 45720
actagaataa agcaacgagt gaacgtaata gagagcttcg tatactctat tcgaaaactc 45780
taagaactta ttaatgaatt ccgtatccac tggattgttt aaaatactaa attgaacact 45840
gttcacatcc ttccaagaag aagacttagt gacggactta acatgagaca taaataaatc 45900
caaatttttt ttacaaacat cactagccac cataatggcg ctatctttca accagctatc 45960
gcttacgcat tttagcagtc taacattttt aaagagacta caatatattc tcatagtatc 46020
gattacacct ctaccgaata aagttggaag tttaataata caatattttt cgtttacaaa 46080
atcaaataat ggtcgaaaca cgtcgaaggt taacatctta taatcgctaa tgtatagatt 46140
gttttcagtg agatgattat tagatttaat agcatctcgt tcacgtttga acagtttatt 46200
gtgtgcgctg aggtcggcaa ctacggcgtc cgctttagta ctcctcccat aatactttac 46260
gctattaatc tttaaaattt catagacttt atctagatcg ctttctggta acatgatatc 46320
atgtgtaaaa agttttaaca tgtcggtcgg cattctattt agatcattaa ctctagaaat 46380
ctgaagaaag taattagctc cgtattccag actaggtaat gggcttttac ctaaagacaa 46440
gttaagttct ggcaatgttt cataaaatgg aagaaggaca tgcgttccct cccggatatt 46500
ttttacaatt tcatccattt acaactctat agtttgtttt cattattatt agttattatc 46560
tcccataatc ttggtaatac ttaccccttg atcgtaagat accttataca ggtcattaca 46620
tacaactacc aattgttttt gtacataata gattggatgg ttgacatcca tggtggaata 46680
aactactcga acagatagtt tatctttccc cctagataca ttggccgtaa tagttgtcgg 46740
cctaaagaat atctttggtg taaagttaaa agttagggtt cttgttccat tattgctttt 46800
tgtcagtagt tcattataaa ttctcgagat gggtccgttc tctgaatata gaacatcatt 46860
tccaaatcta acttctagtc tagaaataat atcggtctta ttcttaaaat ctattccctt 46920
gatgaaggga tcgttaatga acaaatcctt ggcctttgat tcggctgatc tattatctcc 46980
gttatagacg ttacgttgac tagtccaaag acttacagga atagatgtat cgatgatgtt 47040
gatactatgt gatatgtgag caaagattgt tctcttagtg gcatcactat atgttccagt 47100
aatggcggaa aactttttag aaatgttata tataaaagaa ttttttcgtg ttccaaacat 47160
tagcagatta gtatgaagat aaacactcat attatcagga acattatcaa tttttacata 47220
cacatcagca tcttgaatag aaacgatacc atcttctgga acctcaacaa tctcggcaga 47280
ctccggataa ccagtcggtg ggccatcact aacaataact agatcatcca acaatctact 47340
cacatatgca tctatataat ctttttcatc ttgtgagtac cctggatacg aaataaattt 47400
attatccgta tttccataat aaggtttagt ataaacagag agcgatgttg ccgcatgaac 47460
ttcagttaca gtcgccgttg gttggtttat ttgacctatt actctcctag gtttctctat 47520
aaacgatggt ttaatttgta cattcttaac catatatcca ataaagctca attcaggaac 47580
ataaacaaat tctttgttga acgtttcaaa gtcgaacgaa gagtcacgaa taacgatatc 47640
ggatactgga ttgaaggtta ccgttacggt aatttttgaa tcggatagtt taagactgct 47700
gaatgtatct tccacatcaa acggagtttt aatataaacg tatactgtag atggttcttt 47760
aatagtgtca ttaggagtta ggccaataga aatatcatta agttcactag aatatccaga 47820
gtgtttcaaa gcaattgtat tattgataca attattatat aattcttcgc cctcaatttc 47880
ccaaataaca ccgttacacg aagagataga tacgtgatta atacatttat atccaacata 47940
tggtacgtaa ccgaatcttc ccataccttt aacttctgga agttccaaac tcagaaccaa 48000
atgattaagc gcagtaatat actgatccct aatttcgaag ctagcgatag cctgattgtc 48060
tggaccatcg tttgtcataa ctccggatag agaaatatat tgcggcatat acaaagttgg 48120
aatttgacta tcgactgcga agacattaga ccgtttaata gagtcatccc caccgatcaa 48180
agaattaatg atagtattat tcattttcta tttaaaatgg aaaaagctta caataaactc 48240
cgtagagaaa tatctataat ttgtgagttt tccttaaagt aacagcttcc gtaaacgccg 48300
tctttatctc ttagtaggtt tattgtattt atgacctttt ccttatcttc atagaatact 48360
aaaggcaaca aagaaatttt tggttcttct ctaagagcta cgtgagactt aaccatagaa 48420
gccaacgaat ccctacatat tttagaacag aaatacccaa cttcaccacc cttgaatgtc 48480
tcaatactaa taggtctaaa aaccaaatct tgattacaaa accaacactt atcaattaca 48540
ctatttgtct taatagacac atctgccata gatttataat actttggtag tatacaagcg 48600
agtgcttctt ctttagcggg cttaaagact gctttaggtg ctgaaataac cacatctgga 48660
aggcttactc gcttagccat ttaattacgg aactattttt ttatacttct aatgagcaag 48720
tagaaaacct ctcatctaca aaaacatact cgtgtccata atcctctacc atagttacac 48780
gttttttaga tctcatatgt gctaaaaagt tttcccatac taattggtta ctattatttt 48840
tcgtataatt tttaacagtt tgaggtttta gatttttagt tacagaagtg atatcgaata 48900
ttttatccaa aaagaatgaa taattaattg tcttagaagg agtgttttct tggcaaaaga 48960
ataccaagtg cttaaatatt tctactactt cattaatctt ttctgtactc agattcagtt 49020
tctcatcttt tacttgattg attatttcaa agactaactt ataatccttt ttatttattc 49080
tctcgttagc cttaagaaaa ctagatacaa aatttgcatc tacatcatcc gtggatattt 49140
gatttttttc catgatatcc aagagttccg agataatttc tccagaacat tgatgagaca 49200
ataatctccg caatacattt ctcaaatgaa taagtttatt agacacatgg aagtttgact 49260
ttttttgtac ctttgtacat ttttgaaata cagactcgca aaaaatacaa tattcatatc 49320
cttgttcaga tactataccg ttgtgtctac aaccgctaca taatcgtaga ttcatgttaa 49380
cactctacgt atctcgtcgt ccaatatttt atataaaaac attttatttc tagacgttgc 49440
cagaaaatcc tgtaatattt ttagtttttt gggctgtgaa taaagtatcg ccctaatatg 49500
gttaccgtcc tccgccaata tagtagttaa attatccgca catgcagaag aacaccgctt 49560
aggcggattc agtacaatgt tatatttttc gtaccaactc atttaaatat cataatctaa 49620
aatagttctg taatatgtct agcgctaata tattgatcat aatcctgtgc ataaattaag 49680
atacaacaat gtctcgaaat catcgacatg gcttcttcca tagttagaag atcgtcgtca 49740
aagttagcaa cgtgattcat caacatttgc tgttttgagg cagcaaatac tgaaccgtcg 49800
ccattcaacc attcataaaa accatcgtct gaatccattg ataatttctt gtactggttt 49860
ttgagagctc gcatcaatct agcatttcta gctcccggat tgaaaacaga aagaggatcg 49920
tacatccagg gtccattttc tgtaaataga atcgtataat gtcccttcaa gaagatatca 49980
gacgatccac aatcaaagaa ttggtctccg agtttgtaac aaactgcgga ctttaaccta 50040
tacatgatac cgtttagcat gatttctggt gatacgtcaa tcggagtatc atctattaga 50100
gatctaaagc cggtgtaaca ttctccacca aacatattct tattctgacg tcgttctaca 50160
taaaacatca ttgctccatt aacgataaca ggggaatgaa cagcactacc catcacatta 50220
gttcccaatg gatcaatgtg tgtaactcca gaacatcttc catatcctat gttaggagga 50280
gcgaacacca ctcttccact attgccatcg aatgccatag aataaatatc cttggaattg 50340
atagaaatcg gactgtcgga tgttgtgatc atcttcatag gattaacaac tatgtatggt 50400
gccgcctgaa gtttcatatc gtaactgatg ccgtttatag gtctagccac agaaaccaac 50460
gtaggtctaa atccaactat agacaaaata gaagccaata tctgttcttc atctgtcata 50520
acttgagagc atccagtatg aataatcttc attagatggg gatctaccgc atcatcatcg 50580
ttacaataaa aaattcccat tctaatgttc ataattgctt ttctaatcat ggtatgcatg 50640
tttgctctct gaatctctgt ggaaattaga tctgatacac ctgtaatcac tatcggatta 50700
tcctccgtaa gacgattaac caacaacata taattataag actttacttt tctaaattca 50760
taaagttgct ggattaggct ataggtgtct ccatgtacat acgcgttctc gagcgcagga 50820
agtttaatac cgaatagtgc catcagaata ggatgaatat agtaattagt ttctggtttt 50880
ctataaataa aagacaaatc ttgtgaacta gacatatcgg taaaatgcat ggattggaat 50940
cgtgtagtcg acagaagaat atgatgatta gatggagagt atattttatc taactctttg 51000
agttggtcac cgattctagg actagctcga gaatgaataa gtactaaagg atgagtacat 51060
ttcacagaaa cactagcatt gttcaatgtg ctctttacat gggtaaggag ttgaaatagc 51120
tcgtttctat ttgttctgac aatatttagt ttattcataa tgttaagcat atcctgaata 51180
gtaaagttag atgtgtcata cttgttagta gttagatatt tagcaattgc attcccatca 51240
tttctcaatc tcgtactcca atcatgcgtg gatgctactt cgtcgatgga aaccatacaa 51300
tcctttttga taggctgttg agattgatta tttcctgcac gtttaggttt ggtacgttga 51360
tttctagccc ctgcggatat aaagtcatcg tctacaattt tggataatga attgcataca 51420
ctacaagaca aagatttatc agaagtgtga atatgatctt catctaccaa agaaagagtt 51480
tgattagtat aactagattt tagtcctgcg ttagatgtta aaaaaacatc gctattgacc 51540
acggcttcca ttatttatat tcgtagtttt tactcgaaag cgtgatttta atattcaatc 51600
ttattacttt tggaatcgtt caaaaccttt gactaattgt agaatttgat ctattgccct 51660
acgcgtatac tcccttgcat catatacgtt cgtcaccaga tcgtttgttt cggcctgaag 51720
ttggtgcata tctctttcaa cattcgacat gagatcctta agggccatat cgtctagatt 51780
ttgttgagat gctgctcctg gatttggatt ttgttgtgct gttgtacata ctgtaccacc 51840
agtaggtgta ggagtacata cagtggccac aataggaggt tgaggaggtg taaccgttgg 51900
agtagtacaa gaaatacttc catccgattg ttgtgtacat gtagttgttg gtaacgtctg 51960
agaaggttgg gtagatggcg gcgtcgtcgt cttttgatct ttattaaatt tagagataat 52020
atcctgaaca gcattgctcg gcgtcaacgc tggaaggagt gaactcgccg gcgcatcagt 52080
atctgcagac agccaatcaa aaagattaga catatcagat gatgtattag tttgttgtcg 52140
tggttttggt gtaggagccg gtgtagctgt tggaaccggc tgtggagtta tatgaatagt 52200
tggttgtagc ggttggatag gctgtctgct ggcggccatc atattatctc tagctagttg 52260
ttctcgcaac tgtctttgat aatacgactc ttgagacttt agtcctattt caatcgcttc 52320
atcctttttc gtatccggat ccttttcttc agaataatag attgacgact ttggtgtaga 52380
ggattctgcc agcccctgtg agaacttgtt aaagaagtcc atttaaggct ttaaaattga 52440
attgcgatta taagattaaa tggcagacac agacgatatt atcgactatg aatccgatga 52500
tctcaccgaa tacgaggatg atgaagaaga ggaagaagat ggagagtcac tagaaactag 52560
tgatatagat cccaaatctt cttataagat tgtagaatca gcatccactc atatagaaga 52620
tgcgcattcc aatcttaaac atatagggaa tcatatatct gctcttaaac gacgctatac 52680
tagacgtata agtctatttg aaatagcggg tataatagca gaaagctata acttgcttca 52740
acgaggaaga ttacctctag tttcagaatt ttctgacgaa acgatgaagc aaaatatgct 52800
acatgtaatt atacaagaga tagaggaggg ttcttgtcct atagtcatcg aaaagaacgg 52860
agaattgttg tcggtaaacg attttgacaa agatggtcta aaattccatc tagactatat 52920
tatcaaaatt tggaaacttc aaaaacgata ttagaattta tacgaatatc gttctctaaa 52980
tgtcacaatc aagtctcgca tgttcagcaa tttattgtcg tactttatat cgtgttcatt 53040
aacgatatct tgcaaaatag taatgattct atcttccttc gatagatatt cttcagagat 53100
tattgtctta tattctttct tgttatcaga tatgaatttg ataagacttt gaacattatt 53160
gatacccgtc tgtttaattt tttctacaga tattttagtt ttggcagatt ctatcgtatc 53220
tgtcaataga catccaacat cgacattcga cgtcaattgt ctataaatca acgtataaat 53280
tttagaaata acattagcga attgttgtgc attgatgtcg ttattctgaa acagtatgat 53340
tttaggtagc attttcttaa caaagagaac gtatttattg ttactcagtt gaacagatga 53400
tatatccaga ttactaacgc atctgattcc atataccaaa ctttcagaag aaatggtgta 53460
caattgtttg tattcattca atgtctcttt ttcagaaatt agtttagagt cgaatactgc 53520
aataattttc aagagatagt tttcatcaga taagatttta tttagtgtag atatgataaa 53580
actattgttt tgttggagaa cttgatacgc cgcgttctct gtagtcgacg ctctcaaatg 53640
ggaaacaatc tccattattt ttttggaatc ggatacaata tcttcggtat cttgacgcaa 53700
tctagtatac atagagttaa gagaaattag agtttgtaca ttaagcaaca tgtctctaaa 53760
tgtggctgca aacttttcct tttccacatc atctagttta ttatataccg atttcacaac 53820
ggcaccagat ttaaggaacc agaatgaaaa actctgataa ctacaatatt tcatcatagt 53880
tacgatttta tcatcttcta tagttggtgt aatagcgcat acctttttct ccaagactgg 53940
aaccaacgtc ataaaaatgt ttaaatcaaa atccatatca acatctgatg cgctaagacc 54000
agtctcgcgt tcaagattat ctttactaat ggtgacgaac tcatcgtata gaactctaag 54060
tttgtccatt atttatttac agatttagtt gtttaattta tttgtgctct tccagagttg 54120
ggatagtatt tttctaacgt cggtattata ttattaggat ctacgttcat atgtatcata 54180
atattaatca tccacgtttt gataaatcta tctttagctt ctgaaataac gtatttaaac 54240
aaaggagaaa aatatttagc tacggcatca gacgcaataa cattttttgt aaatgtaacg 54300
tatttagacg acagatcttc gttaaaaagt tttccatcta tgtagaatcc atcggttgtt 54360
aacaccattc ccgcgtcaga ttgaatagga gtttgaatag tttgttttgg aaatagatcc 54420
ttcaataact tatagttggg tgggaaaaaa tcgattttat cactagactc tttctttttt 54480
actatcatta cctcatgaac tatttcttga atgagtatat gtattttctt tcctatatcg 54540
gacgcgttca ttggaaaata taccatgtcg ttaactataa gaatattttt atcctcgttt 54600
acaaactgaa taatatcaga tgtagttcgt aaacgaacta tatcatcacc agcacaacat 54660
ctaactatat gatatccact agtttccttt agtcgtttat tatcttgttc catattagca 54720
gtcattccat catttaagaa ggcgtcaaag ataataggga gaaatgacat tttggattct 54780
gttacaactt taccaaaatt aaggatatac ggacttacta tctttttctc aacgtcgatt 54840
tgatgaacac acgatgaaaa tgtacttcga tgagattgat catgtagaaa acaacaaggg 54900
atacaatatt tccacatatc atgaaatata ttaagaaatc ccaccttatt atatttcccc 54960
aaaggatcca tgcatgtaaa cattatgccg ttatcattaa taaagacttc tttctcatcg 55020
gatctgtaaa agttgttact gatttttttc attccaggat ctagataatt aataatgatg 55080
ggttttctat tcttattctt tgtattttgg catatcctag accagtaaac agtttccact 55140
ttggtaaaat cagcagactt ttgaacgcta ttaaacatgg cattaatggc aataactaaa 55200
aatgtaaaat atttttctat gttaggaata tggtttttca ctttaataga tatatggttt 55260
ttggccaaaa tgatagatat ttttttatcc gaggatagta aaatattatt agtcgccgtc 55320
tctataaaaa tgaagctagt ctcgatatcc aattttattc tagaattgat aggagtcgcc 55380
aaatgtacct tatacgttat atctcccttg atgcgttcca tttgtgtatc tatatcggac 55440
acaagatctg taaatagttt tacgttatta atcatcacgg tatcgccgtc gctagataac 55500
gctaatgtac catccaagtc ccaaatggag agatttaact gttcatcgtt tagaataaaa 55560
tgattaccgg tcatattaat aaagtgttca tcgtatctag ataacaacga cttataatta 55620
atgtccaagt cttgaactcg ctgaatgatc ttttttaacc cagttagttt tagattggta 55680
cgaaatatat tgttaaactt tgattctaca gtaatgtcca aatctagttg tggaaatact 55740
tccatcaaca ttgtttcaaa cttgataata ttattatcta catcttcata cgatccaaat 55800
tccggaatag atgtatcgca cgctctggcc acccagataa ccaaaaagtc acacgctcca 55860
ggatatacat tgtataaaaa gctatcgttt tttagtagtg tttttttctg agtatatacg 55920
aagggattaa aaatagtatt atcaacgtaa ctatattcca aattattctt atgagaatag 55980
ataataatat cgtccttaat atctaacaaa tttcctaaat atccctttaa ttgagtcatt 56040
cgaagcgtca atagaatatg tctcttaact atttccggct gttgtatatt taaatgactt 56100
cgtaaaaaat aatatatggg cgacttctca tctatgtaat catatggagt gagatatagg 56160
gctcgttcta cctcctgccc cttacccacc tgtaatacca attgcggact tactatatat 56220
cgcatattta tatcgtgggg taaagtgaaa atctactacc gatgatgtaa gtcttacaat 56280
gttcgaacca gtaccagatc ttaatttgga ggcctccgta gaactagggg aggtaaatat 56340
agatcaaaca acacctatga taaaggaaaa tagcggtttt atatcccgta gtagacgtct 56400
attcgcccat agatctaagg atgatgagag aaaactagca ctacgattct ttttacaaag 56460
actttatttt ttagatcata gagagattca ttatttgttc agatgcgttg acgctgtaaa 56520
agacgtcact attaccaaaa aaaataacat tatcgtggcg ccttatatag cacttttaac 56580
tatcgcatca aaaggatgca aacttacaga aacaatgatt gaagcattct ttccagaact 56640
atataatgaa catagtaaga aatttaaatt caactctcaa gtatccatca tccaagaaaa 56700
actcggatac cagtttggaa actatcacgt ttatgatttt gaaccgtatt actctacagt 56760
agctctggct attcgagatg aacattcatc tggcattttt aatatccgtc aagagagtta 56820
tctggtaagt tcattatctg aaataacata tagattttat ctaattaatc taaaatctga 56880
tcttgttcaa tggagtgcta gtacgggcgc tgtaattaat caaatggtaa atactgtatt 56940
gattacagtg tatgaaaagt tacaactggt catagaaaat gattcacaat ttacatgttc 57000
attggctgtg gaatcaaaac ttccaataaa attacttaaa gatagaaatg aattatttac 57060
aaaattcatc aacgagttaa aaaagaccag ttcattcaag ataagcaaac gcgataagga 57120
tacgctacta aaatatttta cttaggactg gagttagaat ttatagacga ctcatttcgt 57180
ttatcattat tagtattctt cttgttatct tgttcagaaa tatacagcaa tgctatgcct 57240
aatactaaat acattatcat gcttgcaatg gctctaacaa cgacgaacca aaatgaattt 57300
ggtcgtagct tttgttcaca aaaatacata aagaaatgtc tacataaatc tatggcgcca 57360
ttggctactt gaaatagcgc cagtcctcct acagatttta atatagctgt ataacatgac 57420
atttattcat catcaaaaga gacagagtca ccatctgtca tatttagatt ttttttcatg 57480
tgttcaaagt atcctctact catttcatta taatagttta tcatacttag aattttagga 57540
cggatcaatg agtaagactt gactagatcg tcagtagtaa tttgtgcatc gtctattctg 57600
catccgcttc gtcgaataat gtatagcatc gctttgagat tctccatagc tatcaagtct 57660
ttatacaatg acatggaaat atctgtgaat actttatact tctccaacat cgatgcctta 57720
acatcatcgc ctactttagc attgaaaata cgttctattg tgtagatgga tgtagcaaga 57780
tttttaaaca acaatgccat tttacacgat gattgcctca agtctccaat cgtttgttta 57840
gaacgattag ctacagagtc caatgcttgg ctgactagca tattattatc tttagaaatt 57900
gtattcttca atgaggcgtt tatcatatct gtgatttcgt tagtcatatt acagtctgac 57960
tgggttgtaa tgttatccaa catatcacct atggatacgg tacacgtacc agcatttgta 58020
ataatcctat ctaagatgtt gtatggcatt gcgcagaaaa tatcttctcc tgtaatattt 58080
ccactctcga taaatctact cagattattc ttaaatgcct tattctctgg agaaaagata 58140
tcagtgtcca tcatttcatt aatagtatac gcagaaaaga taccacgagt atcaattcta 58200
tccaagatac ttatcggttc cgagtcacag ataatggttt cctctccttc gggagatcct 58260
gcatagaaat atctaggaca atagtttcta tactgtctgt aactctgata atctctaaag 58320
tcactaactg ataccatgaa attgagaaga tcaaacgctg aagtaattaa tttttctgcc 58380
tcgtttttac tacaactagt tttcatcaat gtagtgacga tgtattgttt agttactctt 58440
ggtctaatac tgatgataga gatattatta cttcccataa tggatcttct agtagtcacc 58500
ttaaagccca ttgatgcaaa tagcagatag ataaagtctt ggtatgactc ctttctaata 58560
tagtacggac tacctttgtc acccaacttt atacccacat aagccataac aacctcttta 58620
atagccgttt catgaggttt atcagccatg agcctgagta gttggaagaa tctcatgaat 58680
cctgtctcag aaagtcctat atgcatgata gatttatctt tcctgggaaa ctctcgtata 58740
gtcatagatg aaatactctt caaagtttct gaaataagat tagtaacagt cttacctccg 58800
actactctag gtaacaaaca aactctaata ggtgttttct ctgcggagat aatatcagaa 58860
aggatagagc aataagtagt attattgtga ttataaagac cgaatacata acaggtagaa 58920
tttataaaca tcatgtcctg aaggttttta gacttgtatt cctcgtaatc cataccgtcc 58980
caaaacatgg atttggtaac tttgatagcc gtagatcttt gttccttcgc caacaggtta 59040
aagaaattaa taaagaattt gtggtttcta cctatgtcta caaattgcac gtttggaagc 59100
gccacggtta cattcactgc agcattttga ggatcgcgag tatgaagtac gatgttattg 59160
tttactggta tatctggaaa gaattctacc agtctaggaa taagagattg atatcgcata 59220
gaaatacaaa agttcataat ctcatcatct aagagcattt tgttaccatt gtaataaata 59280
tccactctgt catatgtata aatgaagtac tgttcaaaca tgatgagatg tttatatgtt 59340
ggcatagtag tgagatctac gtttggtaat ggcaatgtat taagattaac tccataatgt 59400
ctagcagcat ctgcgatgtt ataagcgttg tcaaagcggg gtcgatcttg tgctgttata 59460
tattgtctaa cacctataag attatcaaaa tcttgtctgc ttaatacacc gttaacaatt 59520
tttgccttga attcttttat tggtgcatta ataacatcct tatagaggat gttaaacaaa 59580
taagtgttat caaagttaag atctggatat ttcttttctg ctagaacatc cattgagtcg 59640
gagccatctg gtttaatata accaccgata aatctagctc tgtattctgt atccgtcaat 59700
ctaatattaa gaaggtgttg agtgaaaggt ggaagatcgt aaaagctgtg agtattaatg 59760
ataggattag tttccgaact aatgttaatt ggggtattaa taatatctat atttccagcg 59820
ttaagtgtaa cattaaacag ttttaattca cgtgacgtgg tatcaattaa ataattaatg 59880
cccaatttgg atatagcagc ctgaagctca tcttgtttag ttacggatcc taatgagtta 59940
ttaagcaata tatcgaacgg atgaacgaag gttgttttaa gttggtcaca tactttgtaa 60000
tctagacata gatgcggaag aacggtagaa actatacgaa ataaatattc agagtcctct 60060
aattgatcaa gagtaactat tgacttaata ggcatcattt atttagtatt aaatgacgac 60120
cgtaccagtg acggatatac aaaacgattt aattacagag ttttcagaag ataattatcc 60180
atctaacaaa aattatgaaa taactcttcg tcaaatgtct attctaactc acgttaacaa 60240
cgtggtagat agagaacata atgccgccgt agtgtcatct ccagaggaaa tatcctcaca 60300
acttaatgaa gatctatttc cagatgatga ttctccggcc actattatcg aacgagtaca 60360
acctcatact actattattg acgatactcc acctcctacg tttcgtagag agttattgat 60420
atcggaacaa cgtcaacaac gagaaaaaag atttaatatt acagtatcga aaaatgctga 60480
agcaataatg gaatctagat ctatgatatc ttctatgcca acacaaacac catccttggg 60540
agtagtttat gataaagata aaagaattca gatgttggag gatgaagtgg ttaatcttag 60600
aaatcaacga tctaatacaa aatcatctga taatttagat aattttacca gaatactatt 60660
tggtaagact ccgtataaat caacagaagt taataagcgt atagccatcg ttaattatgc 60720
aaatttgaac gggtctccct tatcagtcga ggacttggat gtttgttcag aggatgaaat 60780
agatagaatc tataaaacga ttaaacaata tcacgaaagt agaaaacgaa aaattatcgt 60840
cactaacgtg attattattg tcataaatat tatcgagcaa gcattgctaa aactcggatt 60900
tgaagaaatc aaaggactga gtaccgatat cacttcagaa attatcgatg tggagatcgg 60960
agatgactgc gatgctgtag catcaaaact aggaatcggt aacagtccgg ttcttaatat 61020
tgtattgttt atactcaaga tattcgttaa acgaattaaa attatttaat ttaatacatt 61080
cccatatcca gacaacaatc gtctggatta atctgttcct gtcgtctcat accggacgac 61140
atattaatct ttttattagt aggcatcttt ttagatggtt tctttttccc agcattaact 61200
gagtcgatac ctagaagatc gtgattgatc tctccgacca ttccacgaac ttctaattgg 61260
ccgtctctga cggtaccata aactatttta ccagcattag taacagcttg gacaatctga 61320
ccatccatcg cattgtacga tgtagtagta actgttgttc tacgtctagg agcaccagaa 61380
gtatttttgg agcccttgga tgttgatgta gaagaagacg aggattttga ttttggttta 61440
catgtaatac attttgtatc acatgcgccg gcagtcacat ctgtttgaga attaagatta 61500
ttgttgcctc ctttgacggc tgcatctcca ccgatttgcg ctagtagatt tttaagctgt 61560
ggtgtaatct tattaactgt ttcgatataa tcatcgtaac tgcttctaac ggctaaattt 61620
tttttatccg ccatttagaa gctaaaaata tttttattta tgcagaagat ttaactagat 61680
tatacaatga actaatatga tccttttcca gattatttac aaacttggta ttttttggtt 61740
ctggaggagg cgaatttaaa ttcggacttg gatttggatt ttgtgggttc ttgatcttat 61800
tatacagcgc atataggatg gcgacggtaa ctgctacgca aataccgatc aacaaaagaa 61860
taccaatcat ttattgacaa taacttcact attgatcaag tatgcaatat atcatctttt 61920
cactaaataa gtagtaataa tgattcaaca atgtcgagat atatggacga taataattta 61980
gttcatggaa atatcgctat gattggtatg aatgactccg ctaactctgt ggggcgcgca 62040
gtgctttccc cacatagaat aaattagcat tccgactgtg ataataatac caagtataaa 62100
cgccataata ctcaatactt tccatgtacg agtgggactg gtagacttac taaagtcaat 62160
aaaggcgaag atacacgaaa gaatcaaaag aatgattcca gcgattagca cgccggaaaa 62220
ataatttcca atcataagca tcatatccat ttaactaata aaaattttaa atcgccgaat 62280
gaacaaagtg gaatataaac catataaaaa caatagtttg tactgcaaaa ataatatcta 62340
tttttgtttt cgaagatatg gtaaaattaa atagtagtac acagcatgtt ataactaaca 62400
gcagcaacgg ctcgtaatta cttatcattt actagacgaa aaggtggtgg gatattttct 62460
tgctcaaata atacgaatat atcacccatc cattttatgc gatgtttata tactctaatc 62520
tttaatagat ctatagacga cgggtttacc aacaatatag attttatcga ttcatctaat 62580
ttaaaccctt ccttaaacgt gaatgatcta ttatctggca taacgatgac tctacccgat 62640
gaatcggaca atgtactggg ccatgtagaa taaattatca acgaattatc gtctacgaac 62700
atttatatca tttgttttaa ttttagtacg cgaataaata gatataaaat agaaaataac 62760
agatattaca accaatgtta tggccgcgcc cggccggccg cggccgcttt ttttctagac 62820
actaaataaa tagtaagatt aaattaatta taaaattatg tatataatat taattataaa 62880
attatgtata tgatttacta actttagtta gataaattaa taatacataa attttagtat 62940
attaatatta taaattaata atacataaat tttagtatat taatattata ttttaaatat 63000
ttatttagtg tctagaaaaa aaggcctagc aggcc 63035
<210> 14
<211> 62068
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA fragment 3
<400> 14
ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60
attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120
aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180
gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccgggt 240
attaataata tctatatttc cagcgttaag tgtaacatta aacagtttta attcacgtga 300
cgtggtatca attaaataat taatgcccaa tttggatata gcagcctgaa gctcatcttg 360
tttagttacg gatcctaatg agttattaag caatatatcg aacggatgaa cgaaggttgt 420
tttaagttgg tcacatactt tgtaatctag acatagatgc ggaagaacgg tagaaactat 480
acgaaataaa tattcagagt cctctaattg atcaagagta actattgact taataggcat 540
catttattta gtattaaatg acgaccgtac cagtgacgga tatacaaaac gatttaatta 600
cagagttttc agaagataat tatccatcta acaaaaatta tgaaataact cttcgtcaaa 660
tgtctattct aactcacgtt aacaacgtgg tagatagaga acataatgcc gccgtagtgt 720
catctccaga ggaaatatcc tcacaactta atgaagatct atttccagat gatgattctc 780
cggccactat tatcgaacga gtacaacctc atactactat tattgacgat actccacctc 840
ctacgtttcg tagagagtta ttgatatcgg aacaacgtca acaacgagaa aaaagattta 900
atattacagt atcgaaaaat gctgaagcaa taatggaatc tagatctatg atatcttcta 960
tgccaacaca aacaccatcc ttgggagtag tttatgataa agataaaaga attcagatgt 1020
tggaggatga agtggttaat cttagaaatc aacgatctaa tacaaaatca tctgataatt 1080
tagataattt taccagaata ctatttggta agactccgta taaatcaaca gaagttaata 1140
agcgtatagc catcgttaat tatgcaaatt tgaacgggtc tcccttatca gtcgaggact 1200
tggatgtttg ttcagaggat gaaatagata gaatctataa aacgattaaa caatatcacg 1260
aaagtagaaa acgaaaaatt atcgtcacta acgtgattat tattgtcata aatattatcg 1320
agcaagcatt gctaaaactc ggatttgaag aaatcaaagg actgagtacc gatatcactt 1380
cagaaattat cgatgtggag atcggagatg actgcgatgc tgtagcatca aaactaggaa 1440
tcggtaacag tccggttctt aatattgtat tgtttatact caagatattc gttaaacgaa 1500
ttaaaattat ttaatttaat acattcccat atccagacaa caatcgtctg gattaatctg 1560
ttcctgtcgt ctcataccgg acgacatatt aatcttttta ttagtaggca tctttttaga 1620
tggtttcttt ttcccagcat taactgagtc gatacctaga agatcgtgat tgatctctcc 1680
gaccattcca cgaacttcta attggccgtc tctgacggta ccataaacta ttttaccagc 1740
attagtaaca gcttggacaa tctgaccatc catcgcattg tacgatgtag tagtaactgt 1800
tgttctacgt ctaggagcac cagaagtatt tttggagccc ttggatgttg atgtagaaga 1860
agacgaggat tttgattttg gtttacatgt aatacatttt gtatcacatg cgccggcagt 1920
cacatctgtt tgagaattaa gattattgtt gcctcctttg acggctgcat ctccaccgat 1980
ttgcgctagt agatttttaa gctgtggtgt aatcttatta actgtttcga tataatcatc 2040
gtaactgctt ctaacggcta aatttttttt atccgccatt tagaagctaa aaatattttt 2100
atttatgcag aagatttaac tagattatac aatgaactaa tatgatcctt ttccagatta 2160
tttacaaact tggtattttt tggttctgga ggaggcgaat ttaaattcgg acttggattt 2220
ggattttgtg ggttcttgat cttattatac agcgcatata ggatggcgac ggtaactgct 2280
acgcaaatac cgatcaacaa aagaatacca atcatttatt gacaataact tcactattga 2340
tcaagtatgc aatatatcat cttttcacta aataagtagt aataatgatt caacaatgtc 2400
gagatatatg gacgataata atttagttca tggaaatatc gctatgattg gtatgaatga 2460
ctccgctaac tctgtggggc gcgcagtgct ttccccacat agaataaatt agcattccga 2520
ctgtgataat aataccaagt ataaacgcca taatactcaa tactttccat gtacgagtgg 2580
gactggtaga cttactaaag tcaataaagg cgaagataca cgaaagaatc aaaagaatga 2640
ttccagcgat tagcacgccg gaaaaataat ttccaatcat aagcatcata tccatttaac 2700
taataaaaat tttaaatcgc cgaatgaaca aagtggaata taaaccatat aaaaacaata 2760
gtttgtactg caaaaataat atctattttt gttttcgaag atatggtaaa attaaatagt 2820
agtacacagc atgttataac taacagcagc aacggctcgt aattacttat catttactag 2880
acgaaaaggt ggtgggatat tttcttgctc aaataatacg aatatatcac ccatccattt 2940
tatgcgatgt ttatatactc taatctttaa tagatctata gacgacgggt ttaccaacaa 3000
tatagatttt atcgattcat ctaatttaaa cccttcctta aacgtgaatg atctattatc 3060
tggcataacg atgactctac ccgatgaatc ggacaatgta ctgggccatg tagaataaat 3120
tatcaacgaa ttatcgtcta cgaacattta tatcatttgt tttaatttta gtacgcgaat 3180
aaatagatat aaaatagaaa ataacagata ttacaaccaa tgttatggcc gcgcccaacc 3240
aggtaggcag ttttatttta tcttttacta caggttctcc tggatgtacg tcaccaacgg 3300
cggacgtagt tctagtacaa ttagacgtaa gttccgcttg ggaatttttt aacgctaaag 3360
agttaacgtt aatcgtgcac ccaacgtatt tacatctagt tctttgaaca tcttgattat 3420
aatataacca ttttctatct ctagattcgt cggtgcactc atgtaaccaa cataccctag 3480
gtcctaaata tttatctccg gaattagatt ttggataatt cgcgcaccaa caatttctat 3540
ttcctttatg atcgttacaa aagacgtata atgccgtatc cccaaaagta aaataatcag 3600
gacgaataat tctaataaac tcagaacaat atctcgcatc catatgtttg gagcaaatat 3660
cggaataagt agacatagcc ggtttccgtt ttgcacgtaa ccattctaaa caattggggt 3720
ttccaggatc gtttctacaa aatccagtca tgaaatcatc acaatgttct gtcttgtaat 3780
tattattaaa tatttttgga cagtgtttgg tatttgtctt agaacaacat tttgccacgc 3840
tatcactatc gcccaggaga taatcctttt ttataaaatg acatcgttgc ccggatgcta 3900
tataatcagt agcgtgtttt aaatccttaa tatattcagg agttacctcg ttctgataat 3960
agattaatga tccaggacga aatttgaaag aactacatgg ttctccatga attaatacat 4020
attgtttagc aaattcagga actataaaac tactacaatg atctatcgac ataccatcta 4080
tcaaacaaaa cttgggttta atttctcccg gagatgtttc ataatagtac gtataacttt 4140
cttctgcaaa cttaacagct ctattatatt caggataatt aaaacctaat tccatatatt 4200
tgtctcgtat atctgctatt cctggtgcta ttttgattct attaagagta acggctgccc 4260
ccatttttaa taatcgtcag tatttaaact gttaaatgtt ggtatatcaa catttacctt 4320
atttcccgca gtataaggtt tgttgcaggt atactgttca ggaatggtta catttatact 4380
ttttctatag tcctgtcttt cgatgttcat cacatatgca aagaacagaa taaacaaaat 4440
aatgtaagaa ataatattaa atatctgtga attcgtaaat acattgattg ccataataat 4500
tacagcagct acaatacata caatagacat tcccacagtg ttgccattac ctccacgata 4560
catttgagtt actaagcaat aggtaataac taagctagta agaggcaata gaaaagatga 4620
gataaatatc atcaatatag agattagagg agggctatat agagccaaga cgaacaaaat 4680
caaaccgagt aacgttctaa catcattatt tttgaagatt cccaaataat cattcattcc 4740
tccataatcg ttttgcatca tacctccatc tttaggcata aacgattgct gctgttcctc 4800
tgtaaataaa tctttatcaa gcactccagc acccgcagag aagtcgtcaa gcatattgta 4860
atatcttaaa taactcattt atatattaaa aaatgtcact attaaagatg gagtataatc 4920
tttatgccga actaaaaaaa atgacttgtg gtcaacccct aagtcttttt aacgaagacg 4980
gggatttcgt agaagttgaa ccgggatcat cctttaagtt tctgatacct aagggatttt 5040
acgcctctcc ttccgtaaag acgagtctag tatttgaaac attaacaacg accgataata 5100
aaattactag tatcaatcca acaaatgcgc caaagttata tcctcttcaa cgcaaagtcg 5160
tatctgaagt agtttctaat atgaggaaaa tgatcgaatc aaaacgtcct ctatacatca 5220
ctcttcactt ggcgtgtgga tttggtaaga ctattaccac gtgttatctt atggctacac 5280
acggtagaaa aaccgtcatt tgcgtaccca ataaaatgtt aatacatcaa tggaagacac 5340
aggtagaggc agtcggattg gaacataaga tatccataga tggagtaagt agtctattaa 5400
aggaactaaa gactcaaagt ccggatgtat taatagtagt cagtagacat ctgacaaacg 5460
atgccttttg taaatatatc aataagcatt atgatttgtt catcttggat gaatcacata 5520
cgtataatct gatgaacaat acagcagtta caagattttt agcgtattat cctccgatga 5580
tgtgttattt tttaactgct acacctagac catctaacag aatttattgt aacagtatta 5640
ttaatattgc caagttatcc gatctaaaaa aaactatcta tgcagtagat agtttttttg 5700
agccatattc cacagataat attagacata tgataaaacg attagatgga ccatctaata 5760
aatatcatat atataccgag aagttattat ctgtagacga gcctagaaat caacttattc 5820
ttaataccct ggtagaagaa ttcaagtcag gaactattaa tcgcatttta gttattacta 5880
aactacgtga acatatggta ttcttctaca aacgattatt agattttttc ggatcagagg 5940
ttgtatttat aggagacgcc caaaatagac gtactccaga tatggtcaaa tcaatcaagg 6000
aactaaatag atttatattc gtatccacct tattttattc cggtactggt ttagatattc 6060
ctagtttgga ttctttgttc atttgctcgg cagtaatcaa caatatgcaa atagagcaat 6120
tactagggag ggtatgtcga gaaacagaac tattagatag gacggtatat gtatttccta 6180
gcacatccat caaagaaata aagtacatga taggaaattt cgttcaacga attattagtc 6240
tgtctgtaga taaactagga tttaaacaaa aaagttatcg gaaacatcaa gaatccgatc 6300
ccacttctgt atgtacaaca tcctccagag aagaacgtgt attaaataga atatttaact 6360
cgcaaaatcg ttaagaagtt taagcgacga tccgcatgct gcgcaggcca gtgtattacc 6420
cctcatagta ttaatataat ccaatgatac ttttgtgatg tcggaaatct taaccaattt 6480
agactgacag gcagaacacg tcatgcaatc atcatcgtca tcgataactg tagtcttggg 6540
cttctttttg cggctcttca ttccggaacg cacattggtg ctatccattt aggtagtaaa 6600
aaataagtca gaatatgccc tatagcacga tcgtgcaaaa cctggtatat cgtctctatc 6660
tttatcacaa tatagtgtat cgacatcttt attattattg acctcgttta tcttggaaca 6720
tggaatggga acatttttgt tatcaacggc cacctttgcc ttaattccag atgttgtaaa 6780
attataacta aacagtctat catcgacaca aatgaaattc ttgtttagac gtttgtagtt 6840
tacgtatgcg gctcgttcgc gtctcatttt ttcagatatt gcaggtacta taatattaaa 6900
aataagaatg aaataacata ggattaaaaa taaagttatc atgacttcta gcgctgattt 6960
aactaactta aaagaattac ttagtctgta caaaagtttg aaattttcag attctgcggc 7020
tatagaaaag tataattctt tggtagaatg gggaacatct acttactgga aaataggcgt 7080
gcaaaaggta gctaatgtcg agacgtcaat atctgattat tatgatgagg taaaaaataa 7140
accgtttaat attgatccgg gctattacat tttcttaccg gtatattttg ggagcgtctt 7200
tatttattcg aagggtaaaa atatggtaga acttggatct ggaaactctt ttcaaatacc 7260
agatgatatg cgaagtgcgt gtaacaaagt attagacagc gataacggaa tagactttct 7320
gagatttgtt ttgttaaaca atagatggat aatggaagat gctatatcaa aatatcagtc 7380
tccagttaat atatttaaac tagctagtga gtacggatta aacataccca aatatttaga 7440
aattgaaata gaggaagaca cattatttga cgacgagtta tactctatta tagaacgctc 7500
tttcgatgat aaatttccaa aaatatccat atcgtatatt aagttgggag aacttaggcg 7560
gcaagttgta gactttttca aattctcatt catgtatatt gagtccatca aggtagatcg 7620
tataggagat aatattttta ttcctagcgt tataacaaaa tcaggaaaaa agatattagt 7680
aaaagatgta gaccatttaa tacgatccaa ggttagagaa catacatttg taaaagtaaa 7740
aaagaaaaac acattttcca ttttatacga ctatgatgga aacggaacag aaactagagg 7800
agaagtaata aaacgaatta tagacactat aggacgagac tattatgtta acggaaagta 7860
tttctctaag gttggtagtg caggcttaaa gcaattgact aataaattag atattaatga 7920
gtgcgcaact gtcgatgagt tagttgatga gattaataaa tccggaactg taaaacgaaa 7980
aataaaaaac caatcagcat ttgatttaag cagagaatgt ttgggatatc cagaagcgga 8040
ttttataacg ttagttaata acatgcggtt caaaatagaa aattgtaagg ttgtaaattt 8100
caatattgaa aatactaatt gtttaaataa cccgagtatt gagactatat atggaaactt 8160
taaccagttc gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat tattcgagtg 8220
aaataatatg cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt ttagaagtca 8280
aggataactc cgttagggta ttggatatat caaaattaga ctggagttct gattgggaaa 8340
ggcacatagc taaagatttg tcacaatatg aatacactac agttcttcta gaacgtcagc 8400
ctagaaggtc gccgtacgtc aaatttatct attttattaa aggcttttta tatcatacat 8460
cggctgccaa agttatttgc gtctcgcctg tcatgtctgg taattcatat agagatcgaa 8520
aaaagagatc ggtcgaagca tttcttgatt ggatggacac attcggattg cgagactccg 8580
ttccggatag acgcaaatta gacgatgtag cggatagttt caatttggct atgagatacg 8640
tattagataa atggaatact aattatacac cttataatag gtgtaaatct agaaattaca 8700
taaaaaaaat gtaataacgt tagtaacgcc attatggata atctatttac ctttctacat 8760
gaaatagaag atagatatgc cagaactatt tttaactttc atctaataag ttgcgatgaa 8820
ataggagata tatatggtct tatgaaagaa cgcatttcct cagaggatat gtttgataat 8880
atagtgtata ataaagatat acatcatgcc attaagaaac tagtgtattg cgacatccaa 8940
cttactaaac acattattaa tcagaatacg tatccggtat ttaacgattc ttcacaagtg 9000
aaatgttgtc attatttcga tataaactca gataatagca atattagctc tcgtacagta 9060
gagatatttg agagggaaaa gtcatctctt gtatcatata ttaaaactac caataagaag 9120
agaaaggtca attatgggga aataaagaaa actgtacatg gaggcactaa tgcaaattac 9180
ttttccggta aaaagtctga tgagtatctg agcactacag tcaggtccaa cattaatcaa 9240
ccttggatca aaaccatttc taagagaatg agagtagata tcattaatca ctctatagta 9300
acgcgtggaa aaagctctat attacaaact atagaaatta tttttactaa tagaacatgt 9360
gtgaaaatat tcaaggattc tactatgcac attattctat ccaaggacaa ggatgaaaag 9420
gggtgtatac acatgattga caaattattc tatgtctatt ataatttatt tctgttgttc 9480
gaggatatca tccaaaacga gtactttaaa gaagtagcta atgttgtaaa ccacgtactc 9540
acggctacgg cattagatga gaaattattc ctaattaaga aaatggctga acacgatgtt 9600
tatggagtta gcaatttcaa aatagggatg tttaacctga catttattaa gtcgttggat 9660
cataccgttt tcccctctct gttagatgag gatagcaaaa taaagttttt taaggggaaa 9720
aagctcaata ttgtagcatt acgatctctg gaggattgta taaattacgt gactaaatcc 9780
gagaatatga tagaaatgat gaaggaaaga tcgactattt taaatagcat agatatagaa 9840
acggaatcgg tagatcgtct aaaagaattg cttctaaaat gaaaaaaaaa cactaattca 9900
gaaatggatc aacgactcgg atataagttt ttggtgcctg atcctaaagc cggagttttt 9960
tatagaccgt tacatttcca atatgtatcg tattctaatt ttatattgca tcgattgcat 10020
gaaatcttga ccgtcaagcg gccactctta tcgtttaaga ataatacaga acgaattatg 10080
atagaaatta gcaatgttaa agtgactcct ccagattact cacctataat cgcgagtatt 10140
aaaggtaaga gttatgacgc attagccacg ttcactgtaa atatctttaa agaggtaatg 10200
accaaagagg gtatatccat cactaaaata agtagttatg agggaaaaga ttctcatttg 10260
ataaaaattc cgctactaat aggatacggg aataaaaatc cacttgatac agccaagtat 10320
cttgttccta atgtcatagg tggagtcttt atcaataaac aatctgtcga aaaagtagga 10380
attaatctag tagaaaagat tacaacatgg ccaaaattta gggttgttaa gccaaactca 10440
ttcactttct cgttttcctc cgtatcccct cctaatgtat taccgacaag atatcgccat 10500
tacaagatat ctctggatat atcacaattg gaagcgttga atatatcatc gacaaagaca 10560
tttataacgg tcaatattgt tttgctgtct caatatttat ctagagtgag tctagaattc 10620
attagacgta gtttatcata cgatatgcct ccagaagttg tctatctagt aaacgcgata 10680
atagatagtg ctaaacgaat tactgaatct attactgact ttaatattga tacatacatt 10740
aatgacctgg tggaagctga acacattaaa caaaaatctc agttaacgat caacgagttc 10800
aaatatgaaa tgctgcataa ctttttacct catatgaact atacacccga tcaactaaag 10860
ggattttata tgatatcttt actaagaaag tttctctact gtatctacca cacttctaga 10920
tatccagata gagattcgat ggtttgtcat cgcatcctaa cgtacggcaa atattttgag 10980
acgttggcac atgatgaatt agagaattac ataggcaaca tccgaaacga tatcatgaac 11040
aatcacaaga acagaggcac ttacgcggta aacattcatg tactaacaac tcctggactt 11100
aatcatgcat tttctagtct attgagtgga aagttcaaaa agtcagacgg tagttatcga 11160
acacatcctc actattcatg gatgcagaat atttctattc ctaggagtgt tggattttat 11220
ccggatcaag taaagatttc aaagatgttt tctgtcagaa aataccatcc aagtcaatat 11280
ctttactttt gttcatcgga cgttccggaa agaggtcctc aggtaggttt agtatctcaa 11340
ttgtctgtct tgagttccat tacaaatata ctaacgtctg agtatttgga tttggaaaag 11400
aaaatttgtg agtatatcag atcatattat aaagatgata taagttactt tgaaacagga 11460
tttccaatca ctatagaaaa tgctctagtc gcatctctta atccaaatat gatatgtgat 11520
tttgtaactg actttagacg tagaaaacgg atgggattct tcggtaactt ggaggtaggt 11580
attactttag ttagggatca catgaatgaa attcgcatta atattggagc gggaagatta 11640
gtcagaccat tcttggttgt ggataacgga gagctcatga tggatgtgtg tccggagtta 11700
gaaagcagat tagacgacat gacattctct gacattcaga aagagtttcc gcatgtcatc 11760
gaaatggtag atatagaaca atttactttt agtaacgtat gtgaatcggt tcaaaaattt 11820
agaatgatgt caaaggatga aagaaagcaa tacgatttat gtgactttcc tgccgaattt 11880
agagatggat atgtagcatc ttcactagtg ggaatcaatc acaattctgg acccagagct 11940
attcttggat gtgctcaagc taaacaagct atctcttgtc tgagctcgga tatacgaaat 12000
aaaatagaca atggaattca tttgatgtat ccagagaggc caatcgtgat tagtaaggct 12060
ttagaaactt caaagattgc ggctaattgc ttcggccaac atgttactat agcattaatg 12120
tcgtacaaag gtatcaatca agaggatgga attatcatca aaaaacaatt tattcagaga 12180
ggcggtctcg atattgttac agccaagaaa catcaagtag aaattccgtt ggaaaacttt 12240
aataacaaag aaagagatag gtctaacgcc tattcaaaat tagaaagtaa tggattagtt 12300
agactgaatg ctttcttgga atccggagac gctatagcac gaaatatctc atcaagaact 12360
cttgaagatg attttgctag agataatcag attagctttg atgtttccga aaaatatacc 12420
gatatgtaca aatctcgcgt tgaacgagta caagtagaac ttactgacaa agttaaggta 12480
cgagtattaa ccatgaaaga aagaagaccc attctaggag acaaatttac cactagaacg 12540
agtcaaaagg gaacagtcgc gtatatcgcg gatgaaacgg aacttccata cgatgaaaat 12600
ggtatcacac cagatgtcat tattaattct acatccatct tctctagaaa aactatatct 12660
atgttgatag aggttatttt aacagccgca tattctgcta agccgtacaa caataaggga 12720
gaaaaccgac ctgtctgttt tcctagtagt aacgaaacat ccatcgatac atatatgcaa 12780
ttcgctaaac aatgttatga gcattcaaat ccgaaattgt ctgatgaaga attatcggat 12840
aaaatctttt gtgaaaagat tctctatgat cctgaaacgg ataagcctta tgcatccaaa 12900
gtattttttg gaccaattta ttacttgcgt ctgaggcatt taactcagga caaggcaacc 12960
gttagatgta gaggtaaaaa gacgaagctc attagacagg cgaatgaggg acgaaaacgt 13020
ggaggaggta tcaagttcgg agaaatggag agagactgtt taatagcgca tggtgcagcc 13080
aatactatta cagaagtttt gaaagattcg gaagaagatt atcaagatgt gtatgtttgt 13140
gaaaattgtg gagacatagc agcacaaatc aagggtatta atacatgtct tagatgttca 13200
aaacttaatc tctctcctct cttaacaaaa attgatacca cgcacgtatc taaagtattt 13260
cttactcaaa tgaacgccag aggcgtaaaa gttaaattag atttcgaacg aaggcctcct 13320
tcgttttata aaccattaga taaagttgat ctcaaaccgt cttttctggt gtaatattct 13380
agtttggtag tagatacata tcaatatcat caaattcgag atccgaatta taaaatgggc 13440
gtggattgtt aactatagaa tcggacgtct gatattcgaa aatctgtgga gttttaggtt 13500
ttggtggagg tgtaactgct acttgggata ctgaagtctg atattcagaa agctggggga 13560
tgttctggtt cgacatccac cgatggtgtc acatcactaa tcggttcggt aacgtctgtg 13620
gacgatggag gcaccacttc tacaggttct ggttctttat cctcagtcat caacggagct 13680
acttcaatgc gaggaaatgt ataatttggt aatggtttct catgtggatc tgaagaagag 13740
gtaagatatc tactagaaag ataccgatca cgttctagtt ctcttttgta gaacttaact 13800
ttttctttct ccgcatctag ttgatattcc aacctcttca cgttcgcatg ggttacctcc 13860
gcagttttta cgagcgattt cacgttcagc cttcatgcgt cttatagcat gaattcgctt 13920
atcgttatcg ggtttagctt ctgtcacctt agcaattcct tttttattaa actctacata 13980
atcatatcca tttctattgt ttgttctaat ataaacgagt atagcatcat tgctaaattt 14040
ttcaatagta tcgaaaacag aatatcctaa accatataat atatattcag gaacactcaa 14100
actaaatgtc caggattctc ctaaatacgt aaactttaat agtgcgaaat cattcaaaaa 14160
tctaccactt atagatagat agatagtaca taaatgcgta tagtagtcta cctatctctt 14220
tattatgaaa accggcatta cgatcatata tgtcgtgata tacctgtgat ccgtttacgt 14280
taaaccataa atacatgggt gatcctataa acatgaattt atttctaatt ctcagagcta 14340
tagttaattg accgtgtaat atttgcttac atgcatactt gatacgatca ttaataagat 14400
ttttatcatt gctcgttatt tcagaatcgt atatataagg agtaccatcg tgattcttac 14460
cagatattat acaaaatact atatataaaa tatattgacc cacgttagta atcatgtaaa 14520
tgtttaacgt tttaaatttt gtattcaatg atccattatc atacgctagc atggtcttat 14580
gatattcatt ctttaaaata taatattgtg ttagccattg cattggggct cctaatggag 14640
attttttatt ctcatccatt ttaggatagg ctttcataaa gtccctaata acttcgtgaa 14700
taatgtttct atgttttcta ctgatgcatg tatttgcttc gattttttta tcccatgttt 14760
catctatcat agatttaaac gcagtaatgc tcgcaacatt aacatcttga accgttggta 14820
caattccgtt ccataaattt ataatgttcg ccatttatat aactcatttt ttgaatatac 14880
ttttaattaa caaaagagtt aagttactca tatggacgcc gtccagtctg aacatcaatc 14940
tttttagcca gagatatcat agccgctctt agagtttcag cgtgattttc caacctaaat 15000
agaacttcat cgttgcgttt acaacacttt tctatttgtt caaactttgt tgttacatta 15060
gtaatctttt tttccaaatt agttagccgt tgtttgagag tttcctcatt gtcgtcttca 15120
tcggctttaa caattgcttc gcgtttagcc tctggctttt tagcagccgt tgtagaaaaa 15180
aattcagttg ctggaattgc aagatcgtca tctccgggga aaagagttcc gtccatttaa 15240
agtacagatt ttagaaactg acactctgcg ttatttatat ttggtacaac acatggatta 15300
taaatattga tgttaataac atcagaaaat gtaaagtcta tacattgttg catcgtgtta 15360
aattttctaa tggatctagt attattgggt ccaacttctg cctgaaatcc aaatatggaa 15420
gcggatacaa aaccgtttcc tggataaacc acacatctcc acttttgctt tacatcagaa 15480
attgtgtcgt tgacatcttg aactctccta tctaatgccg gtgttccacc tatagatttt 15540
gaatattcga atgctgcatg agtagcatta aattccttaa tattgccata attttcatat 15600
attgagtaac cctggataaa aagtaaacac accgcagccg tagctaccac aataaaaaaa 15660
attgatagag agttcattta taatctatta gaagctgaca aaattttttt acacgcatca 15720
gacaatgctt taataaatag ttcaacatct acttttgtca tatcgaaccg atggtatgat 15780
tctaacctag aattacatcc gaaaaagttg actatgttca tagtcattaa gtcattaaca 15840
aacaacattc cagactctgg attataagac gatactgttt cgtcacaatt acctacctta 15900
atcatgtgat tatgaatatt ggctattaga gcaccttcta agaaatctat aatatctttg 15960
aaacacgatt taaaatcaaa ccacgaatat acttctacga agaaagttag tttacccata 16020
ggagaaataa ctataaatgg agatctaaat acaaaatccg gatctatgat agttttaaca 16080
ttattatatt ctctattaaa tacctccaca tctaaaaatg ttaattttga aactatgtct 16140
tcgtttatta ccgtacctga actaaacgct ataagctcta ttgtttgaga actctttaaa 16200
cgatattctt gaaatacatg taacaaagtt tcctttaact cggtcggttt atctaccata 16260
gttacagaat ttgtatcctt atctataata taataatcaa aatcgtataa agttatataa 16320
ttatcgcgtt cagattggga tcttttcaaa tagactaaaa accccatttc tctagtaagt 16380
atcttatgta tatgtttgta aaatatcttc atggtgggaa tatgctctac cgcagttagc 16440
cattcctcat tgacagcggt agatgtatta gacaaaacta ttccaatgtt taacaagggc 16500
cattttacga gattattaaa tccttgtttg ataaatgtag ccaatgaggg ttcgagttca 16560
acgacgattg aattctcttc ccgcggatgc tgcatgatga acgacgggat gttgttcgat 16620
tgatttggaa ttctttttcg actttttgtt tatattaaat attttaaaat ttatagcgga 16680
tagcaattca tgtaccacgg ataatgtaga cgcgtattgc gcatcgatat ctttattatt 16740
agataaattt atcaataaat gtgagaagtt tgcctcgtta aggtcttcca tttaaatatt 16800
atataaacat ttgtgtttgt atcttattcg tcttttatgg aatagttttt tactagtaaa 16860
gctgcaatta cacactttgt ccgtaaaaca taaatataaa caccagcttt tatcaatcgt 16920
tccaaaaagt cgacggcgga catttttaac atggcatcta ttttaaatac acttaggttt 16980
ttggaaaaaa catcatttta taattgtaac gattcaataa ctaaagaaaa gattaagatt 17040
aaacataagg gaatgtcatt tgtattttat aagccaaagc attctaccgt tgttaaatac 17100
ttgtctggag gaggtatata tcatgatgat ttggttgtat tggggaaggt aacaattaat 17160
gatctaaaga tgatgctatt ttacatggat ttatcatatc atggagtgac aagtagtgga 17220
acaatttaca aattgggatc gtctatcgat agactttctc taaataggac tattgttaca 17280
aaagttaata attataatta tgatacattt tttgacgatg atgattgatc gctattgcac 17340
aattttgttt ttttactttc taatatagcg tttagattct ttttcatgtg cgaatattga 17400
tttactaaaa tatctatgtt taacttttgt tctataacgt ccttatcggc ggtatcggta 17460
catatacgta attcaccttc acaaaatacg gagtcttcga taataatagc caatcgatta 17520
ttggatctag ctgtctgtat catattcaac atgtttaata tatcctttcg tttccccttt 17580
acaggcatcg atcgtagcat attttccgcg tctgagatgg aaatgttaaa actacaaaaa 17640
tgcgtaatgt tagcccgtcc taatattggt acgtgtctat aagtttggca tagtagaata 17700
atagacgtgt ttaaatgcct tccaaagttt aagaattcta ttagagtatt gcattttgat 17760
agtttatcgc ctacatcatc aaaaataagt aaaaagtgtg ctgatttttt atgattttgt 17820
gcgacagcaa tacatttttc tatgttactt ttagttcgta tcagattata ttctagagat 17880
tcctgactac taacgaaatt aatatgattt ggccaaatgt atccatcata atctggatta 17940
taaacgggtg taaacaagaa tacatgttta tattttttaa ctagtgtaga aaacagagat 18000
agtaaataga tagtttttcc agatccagat cctcccgtta aaaccattct aaacggcatt 18060
tttaataaat tttctcttga aaattgtttt tcttggaaac aattcataat tatatttaca 18120
gttactaaat taatttgata ataaatcaaa atatggaaaa ctaaggtcgt tagtagggag 18180
gagaacaaag aaggcacatc gtgacataaa taacatttat tatcatgatg acaccagaaa 18240
acgacgaaga gcagacatct gtgttctccg ctactgttta cagagacaaa attcagggaa 18300
agaataaacg caaacgcgtg attggtctat gtattagaat atctatggtt atttcactac 18360
tatctatgat taccatgtcc gcgtttctca tagtgcgcct aaatcaatgc atgtctgcta 18420
acgaggctgc tattactgac gccgctgttg ccgttgctgc tgcatcatct actcatagaa 18480
aggttgcgtc tagcactacg caatatgatc acaaagaaag ctgtaatggt ttatattacc 18540
agggttcttg ttatatatta cattcagact accagttatt ctcggatgct aaagcaaatt 18600
gcactgcgga atcatcaaca ctacccaata aatccgatgt cttgactacc tggctcattg 18660
attatgttaa ggatacatgg ggatctgatg gtaatccaat tacaaaaact acatccgatt 18720
atcaagattc tgatgtatca caagaagtta gaaagtattt ttgtgttaaa acaatgaact 18780
aatatttatt tttgtacatt aataaatgaa atcgcttaat agacaaactg taagtaggtt 18840
taagaagttg tcggtgccgg tcgctataat gatgatactc tcaaccatta ttagtggcat 18900
aggaacattt ctgcattaca aagaagaact gatgcctagt gcttgcgcca atggatggat 18960
acaatacgat aaacattgtt atttagatac taacattaaa atgtctacag ataatgcggt 19020
ttatcagtgt cgtaaattac gagccagatt gcctagaccg gatactagac atctgagagt 19080
attgtttagt attttttata aagattattg ggtaagttta aaaaagacca atgataaatg 19140
gttagatatt aataatgata aagatataga tattagtaaa ttaacaaatt ttaaacaact 19200
aaacagtacg acggatgctg aagcgtgtta tatatacaag tctggaaaac tggttaaaac 19260
agtatgtaaa agtactcaat ctgtactatg tgttaaaaaa ttctacaagt gacaacaaaa 19320
aatgaattaa taataagtcg ttaacgtacg ccgccatgga cgccgcgttt gttattactc 19380
caatgggtgt gttgactata acagatacat tgtatgatga tctcgatatc tcaatcatgg 19440
actttatagg accatacatt ataggtaaca taaaaactgt ccaaatagat gtacgggata 19500
taaaatattc cgacatgcaa aaatgctact ttagctataa gggtaaaata gttcctcagg 19560
attctaatga tttggctaga ttcaacattt atagcatttg tgccgcatac agatcaaaaa 19620
ataccatcat catagcatgc gactatgata tcatgttaga tatagaagat aaacatcagc 19680
cattttatct attcccatct attgatgttt ttaacgctac aatcatagaa gcgtataacc 19740
tgtatacagc tggagattat catctaatca tcaatccttc agataatctg aaaatgaaat 19800
tgtcgtttaa ttcttcattc tgcatatcag acggcaatgg atggatcata attgatggga 19860
aatgcaatag taatttttta tcataaaagt tgtaaagtaa ataataaaac aataaatatt 19920
gaactagtag tacgtatatt gagcaatcag aaatgatgct ggtacctctt atcacggtga 19980
ccgtagttgc gggaacaata ttagtatgtt atatattata tatttgtagg aaaaagatac 20040
gtactgtcta taatgacaat aaaattatca tgacaaaatt aaaaaagata aagagttcta 20100
attccagcaa atctagtaaa tcaactgata gcgaatcaga ctgggaggat cactgtagtg 20160
ctatggaaca aaacaatgac gtagataata tttctaggaa tgagatattg gacgatgata 20220
gcttcgctgg tagtttaata tgggataacg aatccaatgt tatggcgcct agcacagaac 20280
acatttacga tagtgttgct ggaagcacgc tgctaataaa taatgatcgt aatgaacaga 20340
ctatttatca gaacactaca gtagtactta atgaagatac caaacagaat cctaactatt 20400
catccaatcc tttcgtaaat tataataaaa ccagtatttg tagcaagtca aatccgttca 20460
ttacagaact caacaataaa tttagtgaga ataatccgtt tagacgagca catagcgatg 20520
attatcttaa taagcaagaa caagatcatg aacacgatga tatagaatca ttggtgtgat 20580
tagtttcctt tttataaaat tgaagtaata tttagtatta ttgctgccgt cacgttgtac 20640
aaatggagat attccctgta ttcggcattt ctaaaattag caattttatt gctaataatg 20700
actgtagata ttatatagat acagaacatc aaaaaattat atctgatgag atcaatagac 20760
agatggatga aacggtactt cttaccaaca tcttaagcgt agaagttgta aatgacaatg 20820
agatgtacca tcttattcct catagattat cgacgattat actctgtatt agttctgtcg 20880
gaggatgtgt tatctctata gataatgacg tcaatggcaa aaatattcta acctttccca 20940
ttgatcatgc tgtaatcata tccccactga gtaaatgtgt cgtagttagc aagggtccta 21000
caaccatatt ggttgttaaa gcggatatac ctagcaaacg attggtaaca tcgtttacaa 21060
acgacatact gtatgtaaac aatctatcac tgattaatta ttcgccgttg tctgtattca 21120
ttattagacg agttaccgac tatttggata gacacatatg cgatcagata tttgcgaata 21180
ataagtggta ttccattata accatcgaca ataagcagtt tcctattcca tcaaactgta 21240
taggtatgtc ctctgccaag tacataaatt ctagcatcga gcaagatact ttaatacatg 21300
tttgtaacct cgagcatcca ttcgacttag tatacaaaaa aatgcagtcg tacaattctg 21360
tacctatcaa ggaacaaata ttgtacggta gaattgataa tataaatatg agcattagta 21420
tttctgtgga ttaatagatt tctagtatgg ggatcattaa tcatctctaa tctctaaata 21480
cctcataaaa cgaaaaaaaa gctattatca aatactgtac ggaatggatt cattctcttc 21540
tctttttatg aaactctgtt gtatatctac tgataaaact ggaagcaaaa aatctgataa 21600
aaagaataag aataagatca aggattatta taaaataaca atagttcctg gttcctcttc 21660
cacgtctact agctcgtggt attatacaca tgcctagtaa tagtctcttt gcgttgacgg 21720
aaagcagact agaaataaca ggctaaaatg ttcagacacc ataatagttc ccaacccaga 21780
taataacaga gtaccatcaa cacattcctt taaactcaat cccaaaccca aaaccgttaa 21840
aatgtatccg gccaattgat agtagataat gaggtgtaca gcgcatgatg atttacacag 21900
taaccaaaat gaaaatactt tagtaattat aagaaatata gatggtaacg tcatcatcaa 21960
caatccaata atatgccgga gagtaaacat tgacggataa aacaaaaatg ctccgcataa 22020
ctctatcatg gcaataacac aaccaaatac ttgtaagatt cctaaattag tagaaaatac 22080
aacggatatc gatgtataag tgatctcgag aaataataag aataaagtaa tgcccgtaaa 22140
gataaacatc aacattgttt ggtaatcatt aaaccaatta gtatgaagtt gaactaattt 22200
cacagtagat tttattccag tattatcccc gcatgtataa gtacctggta agatatcttt 22260
atattccata atcaatgaga catcactatc tgataacgaa tgaagtctag cactagtatg 22320
ccatttactt aatattgtcg tcttggaagt tttattataa gttaaaatat catggttatc 22380
caatttccat ctaatatact ttgtcggatt atctatagta cacggaataa tgatggtatc 22440
attacatgct gtatactcta tggtctttgt agttgttata acaaccaacg tatagaggta 22500
tatcaacgat attctaactc ttgacatttt ttatttattt aaaatgatac ctttgttatt 22560
tattttattc tattttgcta acggtattga atggcataag tttgaaacga gtgaagaaat 22620
aatttctact tacttattag acgacgtatt atacacgggt gttaatgggg cggtatacac 22680
attttcaaat aataaactaa acaaaactgg tttaactaat aataattata taacaacatc 22740
tataaaagta gaggatgcgg aaccaataac ggaaatccca aatgttggaa aatagacggt 22800
tcagacgacc caaaacatag aggtagagga tacgctcctt atcaaaatag caaagtaacg 22860
ataatcagtc acaacggatg tgtactatct gacataaaca tatcaaaaga aggaattaaa 22920
cgatggagaa gatttgacgg accatgtggt tatgatttat acacggcgga taacgtaatt 22980
ccaaaagatg gtttacgagg agcattcgtc gataaagatg gtacttatga caaagtttac 23040
attcttttca ctgatactat cggctcaaag agaattgtca aaattccgta tatagcacaa 23100
atgtgcctaa acgacgaagg tggtccatca tcattgtcta gtcatagatg gtcgacgttt 23160
ctcaaagtcg aattagaatg tgatatcgac ggaagaagtt atagacaaat tattcattct 23220
agaactataa aaacagataa tgatacgata ctatatgtat tcttcgatag tccttattcc 23280
aagtccgcat tatgtaccta ttctatgaat accattaaac aatctttttc tacgtcaaaa 23340
ttggaaggat atacaaagca attgccgtct ccagctcctg gtatatgttt accagctgga 23400
aaagttgttc cacataccac gtttgaagtc atagaaaaat ataatgtact agatgatatt 23460
ataaagcctt tatctaacca acctatcttc gaaggaccgt ctggtgttaa atggttcgat 23520
ataaaggaga aggaaaatga acatcgggaa tatagaatat acttcataaa agaaaattct 23580
atatattcgt tcgatacaaa atctaaacaa actcgtagct cgcaagtcga tgcgcgacta 23640
ttttcagtaa tggtaacttc gaaaccgtta tttatagcag atatagggat aggagtagga 23700
atgccacaaa tgaaaaaaat acttaaaatg taatcttaat cgagtacacc gcacgacaat 23760
gaacaaacat aagacagatt atgctggtta tgcttgctgc gtaatatgcg gtctaattgt 23820
tggaattatt tttacagcga cactattaaa agttgtagaa cgtaaattag ttcatacacc 23880
atcaatagat aaaacgataa aagatgcata tattagagaa gattgtccta ctgactggat 23940
aagctataat aataaatgta tccatttatc tactgatcga aaaacctggg aggaaggacg 24000
taatgcatgc aaagctctaa atccaaattc ggatctaatt aagatagaga ctccaaacga 24060
gttaagtttt ttaagaagca ttagacgcgg atattgggta ggagaatccg aaatattaaa 24120
ccagacaacc ccatataatt ttatagctaa aaatgccacg aagaatggaa ctaaaaaacg 24180
gaaatatatt tgtagtacaa cgaatactcc caaactacat ttttatcata ccactacttc 24240
ggttagatgt tttagaaaaa aataaatatc gccgtaccgt tcttgttttt ataaaaataa 24300
caattaacaa ttatcaaatt ttttctttaa tattttacgt ggttgaccat tcttggtggt 24360
aaaataatct cttagtgttg gaatggaatg ctgtttaatg tttccgcact catcgtatat 24420
tttgacgtat gcagtcacat cgtttacgca atagtcagac tgtagttcta tcatgcttcc 24480
tacatcagaa ggaggaacag ttttaaagtc tcttggtttt aatctattgc cattagtttt 24540
catgaaatcc tttgttttat ccacttcaca ttttaaataa atgtccacta tacattcttc 24600
tgttaatttt actagatcgt catgggtcat agaatttata ggttccgtag tccatggatc 24660
caaactagca aacttcgcgt atacggtatc gcgattagtg tatacaccaa ctgtatgaaa 24720
attaagaaaa cagtttaata aatcaacaga aatatttaat cctccgtttg atacagatgc 24780
gccatattta tggatttcgg attcacacgt tgtttgtctg aggtgttcgt ctagtgttgc 24840
ttctacgtaa acttcgattc ccatatattc tttattgtca gaatcgcata ccgatttatc 24900
atcatacact gtttgaaaac taaatggtat acacatcaaa ataataaata ataacgagta 24960
cattctgcaa tattgttatc gtaattggaa aaatagtgtt cgagtgagtt ggattatgtg 25020
agtattggat tgtatatttt attttatatt ttatattttg tagtaagaat agaatgctaa 25080
tgtcaagttt attccaatag atgtcttatt aaaaaacata tataataaat aacaatggct 25140
gaatggcata aaattatcga ggatatctca aaaaataata agttcgagga tgccgccatc 25200
gttgattaca agactacaaa gaatgttcta gctgctattc ctaacagaac atttgccaag 25260
attaatcctc tcatcactaa tcgtaatatt ctaaaacctc ttattggtca gaaatattgt 25320
attgtatata ctaactctct aatggatgag aacacgtatg ctatggagtt gcttactggg 25380
tacgcccctg tatctccgat cgttatagcg agaactcata ccgcacttat atttttgatg 25440
ggtaagccaa caacatccag acgtgacgtg tatagaacgt gtagagatca cgctacccgt 25500
gtacgtgcaa ctggtaatta aaataaaaag taatattcat atgtagtgtc aattttaaat 25560
gatgatgatg aaatggataa tatccatatt gacgatgtca ataatgccgg tattggcata 25620
cagttcatcg atttttagat ttcattcaga ggatgtggaa ttatgttatg ggcatttgta 25680
ttttgatagg atctataatg tagtaaatat aaaatataat ccgcatattc catatagata 25740
taattttatt aatcgcacgt taaccgtaga tgaactagac gataatgtct tttttacaca 25800
tggttatttt ttaaaacaca aatatggttc acttaatcct agtttgattg tctcattatc 25860
aggaaactta aaatataatg atatacaatg ctcagtaaat gtatcgtgtc tcattaaaaa 25920
tttggcaacg agtacatcta ctatattaac atctaaacat aagacttatt ctctacatcg 25980
gtccacgtgt attactataa taggatacga ttctattata tggtataaag atataaatga 26040
catctatgat tttactgcaa tatgtatgct aatagcgtct acattgatag tgaccatata 26100
cgtgtttaaa aaaataaaaa tgaactctta attatgctat gctattagaa atggataaaa 26160
tcaaaattac ggttgattca aaaattggta atgttgttac catatcgtat aacttggaaa 26220
agataactat tgatgtcaca cctaaaaaga aaaaagaaaa ggatgtatta ttagcgcaat 26280
cagttgctgt cgaagaggca aaagatgtca aggtagaaga aaaaaatatt atcgatattg 26340
aagatgacga tgatatggat gtagaaagcg cataatacga tctataaaaa taagtatata 26400
aatacttttt atttactgta ctcttactgt gtagtggtga taccctactc gattattttt 26460
ttaaaaaaaa atacttattc tgattcttct agccatttcc gtgttcgttc gaatgccaca 26520
tcgacgttaa agatagggga gtagttgaaa tctagttctg cattgttggt acgcacctca 26580
aatgtagtgt tggatatctt caacgtatag ttgttgagta gtgatggttt tctaaataga 26640
attctcttca tatcattctt gcacgcgtac atttttagca tccatcttgg aatcctagat 26700
ccttgttcta ttcccaatgg tttcatcaat agaagattaa acatatcgta cgaacacgat 26760
ggagagtaat cgtagcaaaa gtaagcattt cctttaatct cagatcccgg atactggata 26820
tattttgcag ccaacacgtg catccatgca gcatttccta catatacccg gctatgtacc 26880
gcgttatcat cgactgtacg atacataatg ttaccgtgtt gcttacattg ctcgtaaaag 26940
actttcatca atttgtctcc ttctccgtaa attccagtgg gtcttaggca acaagtatac 27000
aattttgctc cattcatgat tacggaatta ttggctttca taaccagttg ctcggccata 27060
cgtttacttt ttgcgtatac atgtcctggt gatatatcat aaagggtatg ctcatggccg 27120
atgaatggat caccgtgttt attgggtcct attgcttcca tgctactagt atagatcaaa 27180
tacttgattc ctaggtccac acaagctgcc aatatagtct gtgttccata atagtttact 27240
ttcatgattt cattatcggt gtattttcca aatacatcca ctagagcagc tgtatgaata 27300
atcagattta ccccatctag cgcttctctt accttatcaa agtcgtttat atcacattgt 27360
atatagttta taaccttaac tttcgaggtt attggttgtg gatcttctac aatatctatg 27420
actctgattt cttgaacatc atctgcacta attaacagtt ttactatata cctgcctaga 27480
aatccggcac caccagtaac cgcgtacacg gccattgctg ccactcataa tatcagacta 27540
cttattctat tttactaaat aatggctgtt tgtataatag accacgataa tatcagagga 27600
gttatttact ttgaaccagt ccatggaaaa gataaagtta ttggattaaa atccggaacg 27660
tatagtttga taattcatcg ttacggagat attagtcaag gatgtgattc cataggcagt 27720
ccagaaatat ttatcggtaa catctttgta aacagatatg gtgtagcata tgtttattta 27780
gatacagatg taaatatatc tacaattatt ggaaaggcgt tatctatttc aaaaaatgat 27840
cagagattag cgtgtggagt tattggtatt tcttacataa atgaaaagat aatacatttt 27900
cttacaatta acgagaatgg cgtttgatat atcagttaat gcgtctaaaa caataaatgc 27960
attagtttac ttttctactc agcaaaataa attagtcata cgtaatgaag ttaatgatac 28020
acactacact gtcgaatttg atagggacaa agtagttgac acgtttattt catataatag 28080
acataatgac tccatagaga taagaggggt gcttccagag gaaactaata ttggttgcgc 28140
ggttaatacg ccggttagta tgacttactt gtataataag tatagtttta aactgatttt 28200
agcagaatat ataagacaca gaaatactat atccggcaat atttattcgg cattgatgac 28260
actagatgat ttggctatta aacagtatgg agacattgat ctattattta atgagaaact 28320
taaagtagac tccgattcgg gactatttga ctttgtcaac tttgtaaagg atatgatatg 28380
ttgtgattct agaatagtag tagctctatc tagtctagta tctaaacatt gggaattgac 28440
aaataaaaaa tataggtgta tggcattagc cgaacatata tctgatagta ttccaatatc 28500
tgagctatct agactacgat acaatctatg taagtatcta cgcgggcaca ctgagagcat 28560
agaggatgaa tttgattatt ttgaagacga tgattcgtct acatgttctg ccgtaaccga 28620
cagggaaacg gatgtataat tttttttata gcgtgaagga tatgataaaa aatataattg 28680
ttgtatttat cccattccaa tcaccttata tgattctgta acacaatgaa ggagtcttat 28740
agatgtatag aggtcagata ctggtttgat aaactgttta ttccacataa gtatgtttga 28800
ctttatggtt agacccgcat actttaacaa atcactgaaa attggagtta ggtattgacc 28860
tctcagaatc agttgccgtt ctggaacatt aaatgtattt tttatgatat actccaacgc 28920
atttatgtgg gcatacaaca agtcattact aatggagtat tccaagagaa gagatttcaa 28980
cagactgttt atgaactcga atgccgcctc attgtcgctt atattgatga tgtcgaattc 29040
tcccaatatc atcaccgatg agtagctcat cttgttatcg ggatccaagt tttctaaaga 29100
tgtcattaaa ccctcgatca tgaatggatt tatcatcatc gtttttatgt tggacatgag 29160
cttagtccgt ttgtccacat ctatagacga cgatttctga attatttcat atatccctct 29220
ctttaactcc aggaacttgt caggatggtc tactttaata tgttctcgtc taagagatga 29280
aaatctttgg atggttgcac gcgacttttc tctaaaggat cctctcttaa atgaatccat 29340
cttatccttg gacaagatgg acagtctatt ttccttagat ggtttaatat ttttgttacc 29400
catgatctat aaaggtagac ctaatcgtct cggatgacca tatatttatt ttcagtttta 29460
ttatacgcat aaattgtaaa aaatatgtta ggtttacaaa aatgtctcgt ggggcattaa 29520
tcgtttttga aggattggac aaatctggaa aaacaacaca atgtatgaac atcatggaat 29580
ctataccggc aaacacgata aaatatctta actttcctca gagatccact gtcactggaa 29640
agatgataga tgactatcta actcgtaaaa aaacctataa tgatcatata gttaatctat 29700
tattttgtgc aaatagatgg gagtttgcat cttttataca agaacaacta gaacagggaa 29760
ttactttaat agttgataga tacgcattct ctggagtagc gtatgccgcc gctaaaggcg 29820
cgtcaatgac tctcagtaag agttatgaat ctggattgcc taaacccgac ttagttatat 29880
tcttggaatc tggtagcaaa gaaattaata gaaacgtcgg cgaggaaatt tatgaagatg 29940
ttacattcca acaaaaggta ttacaagaat ataaaaaaat gattgaagaa ggagatattc 30000
attggcaaat tatttcttct gaattcgagg aagatgtaaa gaaggagttg attaagaata 30060
tagttataga ggctatacac acggttactg gaccagtggg gcaactgtgg atgtaatagt 30120
gaaattacat tttttataaa tggatgaagc atattactct ggcaacttgg aatcagtact 30180
cggatacgtg tccgatatgc ataccgaact cgcatcaata tctcaattag ttattgccaa 30240
gatagaaact atagataatg atatattaaa caaggacatt gtaaatttta tcatgtgtag 30300
atcaaacttg gataatccat ttatctcttt cctagatact gtatatacta ttatagatca 30360
agagatctat cagaccgaat tgattaattc attagacgac aatgaaatta tcgattgtat 30420
agttaacaag tttatgagct tttataagga taacctagaa aatatagtag atgctatcat 30480
tactctaaaa tatataatga ataatccaga ttttaaaact acgtatgccg aagtactcgg 30540
ttccagaata gcggatatag atattaaaca agtgatacgt gagaatatac tacaattgtc 30600
taataatatc cgcgaacgat atttgtgaaa atattaaaaa aaaatacttt ttttattaaa 30660
tgacgtcgct tcgcgaattt agaaaattat gctgtgatat atatcacgca tcaggatata 30720
aagaaaaatc taaattaatt agagacttta taacagatag ggatgataaa tatttgatca 30780
ttaagctatt gcttcccgga ttagacgata gaatttataa catgaacgat aaacaaatta 30840
taaaattata tagtataata tttaaacaat ctcaggaaga tatgctacaa gatttaggat 30900
acggatatat aggagacact attaggactt tcttcaaaga gaacacagaa atccgtccac 30960
gagataaaag cattttaact ttagaagaag tggatagttt tttaactacg ttatcatccg 31020
taactaaaga atcgcatcaa ataaaattat tgactgatat cgcatccgtt tgtacatgta 31080
atgatttaaa atgtgtagtc atgcttattg ataaagatct aaaaattaaa gcgggccctc 31140
ggtacgtact taacgctatt agtcctcatg cctatgatgt gtttagaaaa tctaataact 31200
tgaaagagat aatagaaaat gcatctaaac aaaatctaga ctctatatct atttctgtta 31260
tgactccaat taatcccatg ttagcggaat cgtgtgattc tgtcaataag gcgtttaaaa 31320
aatttccatc aggaatgttt gcggaagtca aatacgatgg tgaaagagta caagttcata 31380
aaaataataa cgagtttgcc ttctttagta gaaacatgaa accagtactc tctcataaag 31440
tggattatct caaagaatac ataccgaaag catttaaaaa agctacgtct atcgtattgg 31500
attctgaaat tgttcttgta gacgaacata atgtaccgct cccgtttgga agtttaggta 31560
tacacaaaaa gaaagaatat aaaaactcta acatgtgttt gttcgtgttt gactgtttgt 31620
actttgatgg attcgatatg acggacattc cattgtacga acgaagatct tttctcaaag 31680
atgttatggt tgaaataccc aatagaatag tattctcaga gttgacgaat attagtaacg 31740
agtctcagtt aactgacgta ttggatgatg cactaacgag aaaattagaa ggattggtct 31800
taaaagatat taatggagta tacgaaccgg gaaagagaag atggttaaaa ataaagcgag 31860
actatttgaa cgagggttcc atggcagatt ctgccgattt agtagtacta ggtgcttact 31920
atggtaaagg agcaaagggt ggtatcatgg cagtctttct aatgggttgt tacgacgatg 31980
aatccggtaa atggaagacg gttaccaagt gttcaggaca cgatgataat acgttaaggg 32040
agttgcaaga ccaattaaag atgattaaaa ttaacaagga tcccaaaaaa attccagagt 32100
ggttagtagt taataaaatc tatattcccg attttgtagt agaggatcca aaacaatctc 32160
agatatggga aatttcagga gcagagttta catcttccaa gtcccatacc gcaaatggaa 32220
tatccattag atttcctaga tttactagga taagagagga taaaacgtgg aaagaatcta 32280
ctcatctaaa cgatttagta aacttgacta aatcttaata gttacataca aattaaaata 32340
acactattta gttggtggtc gccatggatg gtgttattgt atactgtcta aacgcgttag 32400
taaaacatgg cgaggaaata aatcatataa aaaatgattt catgattaaa ccatgttgtg 32460
aaaaagtcaa gaacgttcac attggcggac aatctaaaaa caatacagtg attgcagatt 32520
tgccatatat ggataatgcg gtatccgatg tatgcaattc actgtataaa aagaatgtat 32580
caagaatatc cagatttgct aatttgataa agatagatga cgatgacaag actcctactg 32640
gtgtatataa ttattttaaa cctaaagatg ccattcctgt tattatatcc ataggaaagg 32700
atagagatgt ttgtgaacta ttaatctcat ctgataaagc gtgtgcgtgt atagagttaa 32760
attcatataa agtagccatt cttcccatgg atgtttcctt ttttaccaaa ggaaatgcat 32820
cattgattat tctcctgttt gatttctcta tcgatgcggc acctctctta agaagtgtaa 32880
ccgataataa tgttattata tctagacacc agcgtctaca tgacgagctt ccgagttcca 32940
attggttcaa gttttacata agtataaagt ccgactattg ttctatatta tatatggttg 33000
ttgatggatc tgtgatgcat gcaatagctg ataatagaac ttacgcaaat attagcaaaa 33060
atatattaga caatactaca attaacgatg agtgtagatg ctgttatttt gaaccacaga 33120
ttaggattct tgatagagat gagatgctca atggatcatc gtgtgatatg aacagacatt 33180
gtattatgat gaatttacct gatgtaggcg aatttggatc tagtatgttg gggaaatatg 33240
aacctgacat gattaagatt gctctttcgg tggctggtat ttggaaagtt ttataggtag 33300
ttgatagaac aaaatacata attttgtaaa aataaatcac tttttatact aatatgacac 33360
gattaccaat acttttgtta ctaatatcat tagtatacgc tacacctttt cctcagacat 33420
ctaaaaaaat aggtgatgat gcaactttat catgtaatcg aaataataca aatgactacg 33480
ttgttatgag tgcttggtat aaggagccca attccattat tcttttagct gctaaaagcg 33540
acgtcttgta ttttgataat tataccaagg ataaaatatc ttacgactct ccatacgatg 33600
atctagttac aactatcaca attaaatcat tgactgctag agatgccggt acttatgtat 33660
gtgcattctt tatgacatcg cctacaaatg acactgataa agtagattat gaagaatact 33720
ccacagagtt gattgtaaat acagatagtg aatcgactat agacataata ctatctggat 33780
ctacacattc accggaaact agttctgaga aacctgatta tatagataat tctaattgct 33840
cgtcggtatt cgaaatcgcg actccggaac caattactga taatgtagaa gatcatacag 33900
acaccgtcac atacactagt gatagcatta atacagtaag tgcatcatct ggagaatcca 33960
caacagacga gactccggaa ccaattactg ataaagaaga agatcataca gttacagaca 34020
ctgtctcata cactacagta agtacatcat ctggaattgt cactactaaa tcaaccaccg 34080
atgatgcgga tctttatgat acgtacaatg ataatgatac agtaccatca actactgtag 34140
gcggtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa atatttggta 34200
ttaccgcatt aattatattg tcggccgtgg caatattctg tattacatat tatatatata 34260
ataaacgttc acgtaaatac aaaacagaga acaaagtcta gatttttgac ttacataaat 34320
gtctgggata gtaaaatcta tcatattgag cgggccatct ggtttaggaa agacagccat 34380
agccaaaaga ctatgggaat atatttggat ttgtggtgtc ccataccact agatttcctc 34440
gtcctatgga acgagaaggt gtcgattacc attacgttaa cagagaggcc atctggaagg 34500
gaatagccgc cggaacatac tgagttttta ggaaatattt acggaacttc taaaactgct 34560
gtgaatacag cggctattaa taatcgtatt tgtgtgatgg atctaaacat cgacggtgtt 34620
agaagtttta aaaatactta cctaatgcct tactcggtgt atataagacc tacctctctt 34680
aaaatggttg agaccaagct tcgttgtaga aacactgaag cggatgatga gattcatcgt 34740
cgtgtgatgt tggcaaaaac tgacatggat gaggcaggtg aagccggtct attcgacact 34800
attatcattg aagatgatgt gaatttagca tatagtaagt taattcagat actacaggac 34860
cgtattagaa tgtattttaa cactaattag agacttaaga cttaaaactt gataattaat 34920
aatataactc gtttttatat gtggctattt caacgtctaa tgtattagtt aaatattaaa 34980
acttaccacg taaaacttaa aatttaaaat gatatttcat tgacagatag atcacacatt 35040
atgaactttc aaggacttgt gttaactgac aattgcaaaa atcaatgggt cgttggacca 35100
ttaataggaa aaggtggatt tggtagtatt tatactacta atgacaataa ttatgtagta 35160
aaaatagagc ccaaagctaa cggatcatta tttaccgaac aggcatttta tactagagta 35220
cttaaaccat ccgttatcga agaatggaaa aaatctcaca atataaagca cgtaggtctt 35280
atcacgtgca aggcatttgg tctatacaaa tccattaatg tggaatatcg attcttggta 35340
attaatagat taggtgcaga tctagatgcg gtgatcagag ccaataataa tagattacca 35400
aaaaggtcgg tgatgttgat cggaatcgaa atcttaaata ccatacaatt tatgcacgag 35460
caaggatatt ctcacggaga tattaaagcg agtaatatag tcttggatca aatagataag 35520
aataaattat atctagtgga ttacggattg gtttctaaat tcatgtctaa tggcgaacat 35580
gttccattta taagaaatcc aaataaaatg gataacggta ctctagaatt tacacctata 35640
gattcgcata aaggatacgt tgtatctaga cgtggagatc tagaaacact tggatattgt 35700
atgattagat ggttgggagg tatcttgcca tggactaaga tatctgaaac aaagaattgt 35760
gcattagtaa gtgccacaaa acagaaatat gttaacaata ctgcgacttt gttaatgacc 35820
agtttgcaat atgcacctag agaattgctg caatatatta ccatggtaaa ctctttgaca 35880
tattttgagg aacccaatta cgacaagttt cggcacatat taatgcaggg tgtatattat 35940
taagtgtggt gtttggttga tgtaaaattt ttgtcgataa aaattaaaaa ataacttaat 36000
ttattattga tctcgtgtgt acaaccgaaa tcatggcgat gttttacgca cacgctctcg 36060
gtgggtacga cgagaatctt catgcctttc ctggaatatc atcgactgtt gccaatgatg 36120
tcagtttata ataacaagta tgacattgta aaagacaaat atatgtggtg ttacagtcag 36180
gtgaacaaga gatatattgg agcactgctg cctatgtttg agtgcaatga atatctacaa 36240
attggagatc cgatccatga tcaagaagga aatcacatat cgccacaaaa actactatgc 36300
tctaagcgga atcgggtacg agagtctaga cttgtgtttg gaaggagtag ggattcatca 36360
tcacgtactt gaaacagaaa acgctgtata tggaaaagtt caacatgatt attctactat 36420
caaagagaag gccaaagaaa tgaatgcact cagttcagga cctatcatcg attaccacgt 36480
ctggatagga gattgtatct gtcaagttac tgctgtggac gtacatggaa aggaaattat 36540
gagaatgaga ttcaaaaagg gtgcggtgct tccgatccca aatctggtaa aagttaaact 36600
tggggagaat gatacagaaa atctttcttc tactatatcg gcggcaccat cgaggtaacc 36660
acctctctgg aagacagtgt gaatcatgta ctcatgaaac gtttggaatc tatacgccat 36720
atgtggtctg ttgtatatga tcattttgat attgtgaatg gtaaagaatg ctgttatgtg 36780
catacgcatt tgtctaatca aaatcttata ccgagtactg taaaaacaaa tttgtacatg 36840
aagactatgg gatcatgcat tcaaatgagt atcttagcga actgaaggaa tcaggtggat 36900
ggagtcccag accagaaatg caggaatttg aatatccaga tggagtggaa gacactgaat 36960
caattgagag attggtagag gagttcttca atagatcaga acttcaggct ggtaaatcta 37020
ttaatgttaa acatacatct gtttcagcta agcaactaag aacacgtata ctctcatctt 37080
ttgccaacac agagggtgga tatttgttca ttggagttga taataataca cacaaagtat 37140
ttggattcac ggtgggttac gactacctca gactgataga gaatgatata gaaaagcata 37200
tcaaaagact ttgtgttgtg tatttctgtg agaagaaaga ggacatcaag tacacgtgtc 37260
gattcatcaa ggtatataaa cctggggatg aggctacctc gacatacgtg tgcgctatca 37320
aagtggaaag atgctgttgt gctgtgtttg cagattggcc agaatcatgg tatcaagaag 37380
tattctccag atgaataggt gtcacatata aaattttaat taatgtaact atagagaaca 37440
aataataggt tgtaatatca tatagacaat aactaacaat taattagtaa ctgttatctc 37500
tttttaacta actaactata cctattaata catcgtaatt atagttctta acatctatta 37560
atcattgatt cgcttcttta attttttata aaccaacatt gttaattgaa aagggataac 37620
atgttacaga atataaatta tatatggatt ttttttaaaa aggaaatact tgactggagt 37680
gtatatttat ctcttcatta tatagcacgc gtgttttcca atttttccac atcccatata 37740
atacaggatt ataatctcgt tcgaacatac gagaaagtgg ataaaacaat agttgatttt 37800
ttatctaggt tgccaaattt attccatatt ttagaatatg gggaaaatat tctacatatt 37860
tattctatgg atgatgctaa tacgaatatt ataatttttt ttctagatag agtattaaat 37920
attaataaga acgggtcatt tatacacaat ctcaggttat catcatccat taatataaaa 37980
gaatatgtat atcaattagt taataatgat catccagata ataggataag actaatgctt 38040
gaaaatggac gtagaacaag acattttttg tcctatatat cagatacagt taatatctat 38100
atatgtattt tatatagatg ccgaagacag ttacggttgt acattattac atagatgtat 38160
atatcactat aagaaatcag aatcagaatc agaatcatac aatgaattaa ttaagatatt 38220
gttaaataat ggatcagatg tagataaaaa agatacgtac ggaaacacac cttttatcct 38280
attatgtaaa cacgatatca acaacgtgga attgtttgag atatgtttag agaatgctaa 38340
tatagactct gtagacttta atagatatac acctcttcat tatgtctcat gtcgtaataa 38400
atatgatttt gtaaagttat taatttctaa aggagcaaat gttaatgcgc gtaataaatt 38460
cggaactact ccattttatt gtggaattat acacggtatc tcgcttataa aactatattt 38520
ggaatcagac acagagttag aaatagataa tgaacatata gttcgtcatt taataatttt 38580
tgatgctgtt gaatctttag attatctatt atccagagga gttattgata ttaactatcg 38640
tactatttac gacgctgtca gttataatgc gtataatacg ttggtctatc tattaaacag 38700
aaatggtgat tttgagacga ttactactag tggatgtaca tgtatttcgg aagcagtcgc 38760
aaacaacaac aaaataataa tggaagtact attgtctaaa cgaccatctt tgaaaattat 38820
gatacagtct atgatagcaa ttactaaaca taaacagcat aatgcagatt tattgaaaat 38880
gtgtataaaa tatactgcgt gtatgaccga ttatgatact cttatagatg tacaatcact 38940
acagcaatat aaatggtata ttttaagatg tttcgatgaa atagatatca tgaagagatg 39000
ttatataaaa aataaaactg tattccaatt agttttttgt atcaaagaca ttaatacttt 39060
aatgagatac ggtaaacatc cttctttcgt gaagtgcact agtctcgacg tatacggaag 39120
tcgtgtacgt aatatcatag catctattag atatcgtcag agattaatta gtctattatc 39180
caagaagctg gatcctggag ataaatggtc gtgttttcct aacgaaataa aatataacga 39240
taacgaactg tccacatatc taaaaatctt ataaacacta ttaaaatata aaatcacact 39300
acatcattgt ttccttttag tgctcgacag tgtatactat ttttaacgct cataaataaa 39360
aatgaaaacg atttccgttg ttacgttgtt atgcgtacta cctgctgttg tttattcaac 39420
atgtactgta cccactatga ataacgctaa attaacgtct accgaaacat cgtttaataa 39480
taaccagaaa gttacgttta catgtgatca gggatatcat tcttcggatc caaatgctgt 39540
ctgcgaaaca gataaatgga aatacgaaaa tccatgcaaa aaaatgtgca cagtttctga 39600
ttacatctct gaactatata ataaaccgct atacgaagtg aattccacca tgacactaag 39660
ttgcaacggc gaaacaaaat attttcgttg cgaagaaaaa aatggaaata cttcttggaa 39720
tgatactgtt acgtgtccta atgcggaatg tcaacctctt caattagaac acggatcgtg 39780
tcaaccagtt aaagaaaaat actcatttgg ggaatatata actatcaact gtgatgttgg 39840
atatgaggtt attggtgctt cgtacataag ttgtacagct aattcttgga atgttattcc 39900
atcatgtcaa caaaaatgtg atataccgtc tctatctaat ggattaattt ccggatctac 39960
attttctatc ggtggcgtta tacatcttag ttgtaaaagt ggttttatac taacgggatc 40020
tccatcatcc acatgtatcg acggtaaatg gaatcccata ctcccaacat gtgtacgatc 40080
taacgaaaaa tttgatccag tggatgatgg tcccgacgat gagacagatt tgagcaaact 40140
ctcgaaagac gttgtacaat atgaacaaga aatagaatcg ttagaagcaa cttatcatat 40200
aatcatagtg gcgttaacaa ttatgggcgt catattttta atctccgtta tagtattagt 40260
ttgttcctgt gacaaaaata atgaccaata taagttccat aaattgctac cgtgaatata 40320
aatccgttaa aataatgaat aattaataat taataattta ataacaaaca agtatcaaaa 40380
gattaaagac ttatagctag aatcaattga gatgtcttct tcagtggatg ttgatatcta 40440
cgatgccgtt agagcatttt tactcaggca ctattataac aagagattta ttgtgtatgg 40500
aagaagtaac gccatattac ataatatata caggctattt acaagatgcg ccgttatacc 40560
gttcgatgat atagtacgta ctatgccaaa tgaatcacgt gttaaacaat gggtgatgga 40620
tacacttaat ggtataatga tgaatgaacg cgatgtttct gtaagcgttg gcaccggaat 40680
actattcatg gaaatgtttt tcgattacaa taaaaatagt atcaacaatc aactaatgta 40740
tgatataatt aatagcgtat ctataattct agctaatgag agatatagaa gcgcttttaa 40800
cgacgatggt atatacatcc gtagaaatat gattaacaag ttgtacggat acgcatctct 40860
aactactatt ggcacgatcg ctggaggtgt ttgttattat ctgttgatgc atctagttag 40920
tttgtataaa taattatttc aatatactag ttaaaatttt aagattttaa atgtataaaa 40980
aactaataac gtttttattt gtaataggtg cattagcatc ctattcgaat aatgagtaca 41040
ctccgtttaa taaactgagt gtaaaactct atatagatgg agtagataat atagaaaatt 41100
catatactga tgataataat gaattggtgt taaattttaa agagtacaca atttctatta 41160
ttacagagtc atgcgacgtc ggatttgatt ccatagatat agatgttata aacgactata 41220
aaattattga tatgtctact attcaacgca gaggtcacac gtgtagaata tctaccaaat 41280
tatcatgcca ttatgataag tacccttata ttcacaaata tgatggtgat gagcgacaat 41340
attctattac tgcagaggga aaatgctata aaggaataaa atatgaaata agtatgatca 41400
acgatgatac tctattgaga aaacatactc ttaaaattgg atctacttat atatttgatc 41460
gtcatggaca tagtaataca tattattcaa aatatgattt ttaaaaattt aaaatatatt 41520
atcacttcag tgacagtagt caaataacaa acaacaccat gagatatatt ataattctcg 41580
cagttttgtt cattaatagt atacacgcta aaataactag ttataagttt gaatccgtca 41640
attttgattc caaaattgaa tggactgggg atggtctata caatatatcc cttaaaaatt 41700
atggcatcaa gacgtggcaa acaatgtata caaatgtacc agaaggaaca tacgacatat 41760
ccgcatttcc aaagaatgat ttcgtatctt tctgggttaa atttgaacaa ggcgattata 41820
aagtggaaga gtattgtacg ggaccaccga ctgtaacatt aactgaatac gacgaccatc 41880
cgtatgctac tagaggtagc aaaaagattc ctatttacaa acgcggtgac atgtgtgata 41940
tctacttgtt gtatacggct aacttcacat tcggagattc taaagaacca gtaccatatg 42000
atatcgatga ctacgattgc acgtctacag gttgcagcat agactttgtc acaacagaaa 42060
aagtgtgcgt gacagcacag ggagccacag aagggtttct cgaaaaaatt actccatgga 42120
gttcgaaagt atgtctgaca cctaaaaaga gtgtatatac atgcgcaatt agatccaaag 42180
aagatgttcc caatttcaag gacaaaatgg ccagagttat caagagaaaa tttaactaaa 42240
tttctcggta gcacatcaaa tgatgttacc acttttctta gcatgcttaa cttgactaaa 42300
tattcataac taatttttat taatgataca aaaacgaaat aaaactgcat attatacact 42360
ggttaacgcc cttataggct ctaaccattt tcaagatgag gtccctgatt atagtccttc 42420
tgttcccctc tatcatctac tccatgtcta ttagacgatg tgagaagact gaagaggaaa 42480
catggggatt gaaaataggg ttgtgtataa ttgccaaaga tttctatccc gaaagaactg 42540
attgcagtgt tcatctccca actgcaagtg aaggcaatgg attcagggat atacgaaaca 42600
ccgataaatt ataaaaaaag caatgtgtcc gctgtttccg ttaataatac tattttcgta 42660
actggcggat tattcataaa taactctaat agcacgatcg tggttaacaa tatggaaaaa 42720
cttgacattt ataaagacaa acaatggtcg attatagaaa tgcctatggc tagggtatat 42780
cacggcatcg actcgacatt tggaatgtta tattttgccg gaggtctatc cgttaccgaa 42840
caatatggta atttagagaa aaacaacgag atatcttgtt acaatcctag aacgaataag 42900
tggtttgata tttcatatac tatttataag atatccatat catcattgtg taaactaaat 42960
aacgtcttct atgtatttag taaggacatt ggatatgtgg aaaagtatga tggtctcccc 43020
gctataaagg cattatcaac ttctccttat tgattgaaaa tgaaaatata aatagttttt 43080
atgtatagca gtattaccct atagttttat tgcttactac taacatggat acagatacag 43140
atgttacaaa tgtagaagat atcatgaatg aaatagatag agagaaagaa gaaatactaa 43200
aaaatgtaga aattgaaaat aataaaaaca ttaacaagaa tcatcccaat gaatatatta 43260
gagaagcact cgttattaat acaagtagta atagtgattc cattgataaa gaagttatag 43320
aatgtatcag tcacgatgta ggaatataga tcatatctac taatttttat aatcaataca 43380
aaacataaaa aacaactcgt tattacatag caggcatgga atccttcaag tattgttttg 43440
ataacgatgg caagaaatgg attatcggaa atactttata ttctggtaat tcaatactct 43500
ataaggtcag aaaaaatttc actagttcgt tctacaatta cgtaatgaag atagatcaca 43560
aatcacacaa gccattgttg tctgaaatac gattctatat atctgtattg gatcctttga 43620
ctatcgacaa ctggacacgg gaacgtggta taaagtattt ggctattcca gatctgtatg 43680
gaattggaga aaccgatgat tatatgttct tcgttataaa gaatttggga agagtattcg 43740
ccccaaagga tactgaatca gtcttcgaag catgcgtcac tatgataaac acgttagagt 43800
ttatacactc tcgaggattt acccatggaa aaatagaacc gaggaatata ctgattagaa 43860
ataaacgtct ttcactaatt gactattcta gaactaacaa actatacaag agtggaaact 43920
cacatataga ttacaacgag gacatgataa cttcaggaaa tatcaattat atgtgtgtag 43980
acaatcatct tggagcaaca gtttcaaaac gaggagattt agaaatgttg ggatattgca 44040
tgatagaatg gttcggtggc aaacttccat ggaaaaacga aagtagtata aaagtaataa 44100
aacaaaaaaa agaatataaa aaatttatag ctactttctt tgaggactgt tttcctgaag 44160
gaaatgaacc tctggaatta gttagatata tagaattagt atacacgtta gattattctc 44220
aaactcctaa ttatgacaga ctacgtagac tgtttataca agattgaaat attctttttt 44280
tatagagtgt ggtagtgtta cggatatcta atattaatat tagactatct ctatcgcgct 44340
acacgaccaa tatcgattac tatggatatc ttctatgaaa ggagagaatg tattcatttc 44400
tccagcgtca atctcgtcag tattgacaat actgtattat ggagctaatg gatccactgc 44460
tgaacagcta tcaaaatatg tagaaaagga ggagaacacg gataaggtta gcgctcagaa 44520
tatctcattc aaatccatga ataaagtata tgggcgatat tctgccgtgt ttaaagattc 44580
ctttttgaga aaaattggcg ataagtttca aactgttgac ttcactgatt gtcgcactat 44640
agatgcaatc aacaagtgtg tagatatctt tactgagggg aaaatcaatc cactattgga 44700
tgaacaattg tctcctagca attagtgccg tatactttaa agcaaaatgg ttgacgccat 44760
tcgaaaagga atttaccagt gattatccct tttacgtatc accaacggaa atggtagacg 44820
taagtatgat gtctatgtac ggcgagctat ttaatcacgc atctgtaaaa gaatcattcg 44880
gtaacttttc aatcatagaa ctgccatatg ttggagatac tagtatgatg gtcattcttc 44940
cagacaagat tgatggatta gaatccatag aacaaaatct aacagataca aattttaaga 45000
aatggtgtaa ctctctggaa gctacgttta tcgatgttca cattcccaag tttaaggtaa 45060
caggctcgta taatctggtg gatactctag taaagtcagg actgacagag gtgttcggtt 45120
caactggaga ttatagcaat atgtgtaatt tagatgtgag tgtcgacgct atgatccaca 45180
aaacgtatat agatgtcaat gaagagtata cagaagcagc tgcagcaact tgtgcactgg 45240
tgtcagactg tgcatcaaca attacaaatg agttctgtgt agatcatccg ttcatctatg 45300
tgattaggca tgttgatgga aaaatttttt tcgttggtag atattgctct ccgacaacta 45360
attgttaacc atttttttta aaaaaataga aaaaacatgt ggtattagtg caggtcgtta 45420
ttcttccaat tgcaattggt aagatgacgg ccaactttag tacccacgtc ttttcaccac 45480
agcactgtgg atgtgacaga ctgaccagta ttgatgacgt caaacaatgt ttgactgaat 45540
atatttattg gtcgtcctat gcataccgca acaggcaatg cgctggacaa ttgtattcca 45600
cactcctctc ttttagagat gatgcggaat tagtgttcat cgacattcgc gagctggtaa 45660
aaaatatgcc gtgggatgat gtcaaagatt gtgtagaaat catccgttgt tatataccgg 45720
atgagcaaaa aaccatcatc ggactttgtg catatgctgc tacttactgg ggaggtgaag 45780
accatcccac tagtaacagt ctgaacgcat tgtttgtgat gcttgagatg ctaaattacg 45840
tggattataa catcatattc cggcgtatga attgatgagt tgtacatctt gacattttct 45900
tctttcttct cttctccctt tcccagaaac aaactttttt tacccactat aaaataaaat 45960
gagtatacta cctgttatat ttctttctat atttttttat tcttcattcg ttcagacttt 46020
taacgcgcct gaatgtatcg acaaagggca atattttgca tcattcatgg agttagaaaa 46080
cgagccagta atcttaccat gtcctcaaat aaatacgcta tcatccggat ataatatatt 46140
agatatttta tgggaaaaac gaggagcgga taatgataga attataccga tagataatgg 46200
tagcaatatg ctaattctga acccgacaca atcagactct ggtatttata tatgcattac 46260
cacgaacgaa acctactgtg acatgatgtc gttaaatttg acaatcgtgt ctgtctcaga 46320
atcaaatata gatcttatct cgtatccaca aatagtaaat gagagatcta ctggcgaaat 46380
ggtatgtccc aatattaatg catttattgc tagtaacgta aacgcagata ttatatggag 46440
cgggcatcga cgccttagaa ataagagact taaacaacgg acacctggaa ttattaccat 46500
agaagatgtt agaaaaaatg atgctggtta ttatacatgt gttttagaat atatatacgg 46560
tggcaaaaca tataacgtaa ccagaattgt aaaattagag gtacgggata aaataatacc 46620
ttctactatg caattaccag aaggtgttgt aacttcaata ggtagtaatt tgactattgc 46680
gtgtagagta tcgttgagac ctcccacaac ggatgcagac gtcttttgga taagtaatgg 46740
tatgtattac gaagaagatg atggggacgg agacggtaga ataagtgtag caaataaaat 46800
ctatatgacc gataagagac gtgttattac atcccggtta aacattaatc ctgtcaagga 46860
agaagatgct acaacgttta cgtgtatggc gtttactatt cctagcatca gcaaaacagt 46920
tactgttagt ataacgtgaa tgtatgttgt tacatttcca tgtcaattga gtttataaga 46980
atttttatac attatcttcc aacaaacaat tgacgaacgt attgctatga ttaactccca 47040
cgatactatg catattatta atcattaact tgcagactat acctagtgct attttgacat 47100
actcatgttc ttgtgtaatt gcggtatcta tattattaaa gtacgtaaat ctagctatag 47160
ttttattatt taattttaga taatataccg tctccttatt tttaaaaatt gccacatcct 47220
ttattaaatc atgaatggga atttctatgt catcgttaat atattgtgaa caacaagagc 47280
agatatctat aggaaagggt ggaatgcgat acattgatct atgtagtttt aaaacacacg 47340
cgaactttga agaatttata taaatcattc catcgataca tccttctatg ttgacatgta 47400
tatatccagg aattctttta ttaatgtcag gaaatgtata aactaaaaca ttgcccgaaa 47460
gcggtgcctc tatctgcgtt atatccgttc ttaacttaca aaatgtaacc aatacctttg 47520
catgacttgt tttgttcggc aacgttagtt taaacttgac gaatggatta attacaatag 47580
catgatccgc gcatctatta agttttttta ctttaacgcc cttgtatgtt tttacagaga 47640
ctttatctaa atttctagtg cttgtatgtg ttataaatat aacgggatat agaactgaat 47700
cacctacctt agatacccaa ttacatttta tcagatccag ataataaaca aattttgtcg 47760
ccctaactaa ttctatattg ttatatattt tacaattggt tatgatatca tgtaataact 47820
tggagtctaa cgcgcatcgt cgtacgttta tacaattgtg atttagtgta gtatatctac 47880
acatgtattt ttccgcacta tagtattctg gactagtgat aaaactatcg ttatatctgt 47940
cttcaatgaa ctcatcgaga tattgctctc tgtcatattc atacacctgc ataaactttc 48000
tagacatctt acaatccgtg ttattttagg atcatattta catatttacg ggtatatcaa 48060
agatgttaga ttagttaatg ggaatcgtct ataataatga atattaaaca attatatgag 48120
gacttttacc acaaagcatc ataaaaatga gtcgtcgtct gatttatgtt ttaaatatca 48180
accgcgaatc aactcataaa atacaagaga atgaaatata tacatatttt agtcattgca 48240
atatagacca tacttctaca gaacttgatt ttgtagttaa aaactatgat ctaaacagac 48300
gacaacctgt aactgggtat actgcactac actgctattt gtataataat tactttacaa 48360
acgatgtact gaagatatta ttaaatcatg gagtggatgt aacgatgaaa accagtagcg 48420
gacgtatgcc tgtttatata ttgcttacta gatgttgtaa tatttcacat gatgtagtga 48480
tagatatgat agacaaagat aaaaaccact tatcgcatag agactattcc aacctactac 48540
tagagtatat aaaatctcgt tacatgttat tgaaggaaga ggatatcgat gagaacatag 48600
tatccacttt attagataag ggaatcgatc ctaactttaa acaagacgga tatacagcgt 48660
tacattatta ttatttgtgt ctcgcacacg tttataaacc aggtgagtgt agaaaaccga 48720
taacgataaa aaaggccaag cgaattattt ctttgtttat acaacatgga gctaatctaa 48780
acgcgttaga taattgtggt aatacaccat tccatttgta tcttagtatt gaaatgtgta 48840
ataatattca tatgactaaa atgctgttga cttttaatcc gaatttcaaa atatgtaata 48900
atcatggatt aacgcctata ctatgttata taacttccga ctacatacaa cacgatattc 48960
ttgttatgtt aatacatcac tatgaaacaa atgttggaga aatgccgata gatgagcgtc 49020
gtataatcgt attcgagttt atcaaaacat attctacacg tccggcagat tcgataactt 49080
atttgatgaa taggtttaaa aatatagata tttatacccg ctatgaagga aagacattat 49140
tacacgtagc atgtgaatat aataatacac acgtaataga ttatcttata cgtatcaacg 49200
gagatataaa tgcgttaacc gacaataaca aacacgctac acaactcatt atagataaca 49260
aagaaaattc cccatatacc attaattgtt tactgtatat acttagatat attgtagata 49320
agaatgtgat aagatcgttg gtggatcaac ttccatctct acctatcttc gatataaaat 49380
catttgagaa attcatatcc tactgtatac ttttagatga cacattttac aatagacacg 49440
ttaggaatcg caattctaaa acgtatcgat acgcattttc aaaatacatg tcgtttgata 49500
aatacgatgg tataataact aaatgtcata aagaaacaat attgctcaaa ctatccactg 49560
ttctagacac tacactatat gcagttttaa gatgccataa ttcgaaaaag ttaagaagat 49620
acctcaacga gttaaaaaaa tataataacg ataagtcctt taaaatatat tctaatatta 49680
tgaatgagag ataccttaat gtatattata aagatatgta cgtgtcaaag gtatatgata 49740
aactatttcc tgttttcaca gataaaaatt gtctactaac attactacct tcagaaatta 49800
tatacgaaat attatacatg ctgacaatta acgatcttta taatatatcg tatccaccta 49860
ccaaagtata gttgtatttt tctcatgcga tgtgtgtaaa aaaactgata ttatataaat 49920
attttagtgc cgtataatga agatgacgat gaaaatgatg gtacatatat atttcgtatc 49980
attattgtta ttgctattcc acagttacgc catagacatc gaaaatgaaa tcacagaatt 50040
cttcaataaa atgagagata ctctaccagc taaagactct aaatggttga atccagcatg 50100
tatgttcgga ggcacaatga atgatatagc cgctctagga gagccattca gcgcaaagtg 50160
tcctcctatt gaagacagtc ttttatcgca cagatataaa gactatgtgg ttaaatggga 50220
gaggctagaa aaaaatagac ggcgacaggt ttctaataaa cgtgttaaac atggtgattt 50280
atggatagcc aactatacat ctaaattcag taaccgtagg tatttgtgta ccgtaactac 50340
aaagaatggt gactgtgttc agggtatagt tagatctcat attaaaaaac ctccttcatg 50400
cattccaaaa acatatgaac taggtactca tgataagtat ggcatagact tatactgtgg 50460
aattctttac gcaaaacatt ataataatat aacttggtat aaagataata aggaaattaa 50520
tatcgacgat attaagtatt cacaaacggg aaagaaatta attattcata atccagagtt 50580
agaagatagt ggaagataca actgttacgt tcattacgac gacgttagaa tcaagatgta 50640
aaatacttac ggttataccg tcgcaagacc acaggtttaa actaatacta gatccaaaaa 50700
tcaacgtaac gataggagaa cctgccaata taacatgcac tgctgtgtca acgtcattat 50760
tgattgacga tgtactgatt gaatgggaaa atccatccgg atggcttata ggattcgatt 50820
ttgatgtata ctctgtttta actagtagag gcggtatcac cgaggcgacc ttgtactttg 50880
aaaatgttac tgaagaatat ataggtaata catataaatg tcgtggacac aactattatt 50940
ttgaaaaaac ccttacaact acagtagtat tggagtaaat acacaatgca tttttatata 51000
cattactgaa taattattat tattatttat atcgtatttg tgctataacg cgactatcta 51060
ggtatttgta tctcaccgat agagaacata taaatgtaga ctctattaaa cagttgtgta 51120
aaatatcaga tcctaataga tgtggatgta cggctttaga aatgagttca ttaaaatatg 51180
tgatatcaac ggaacatatt tatataatta tactattgct gttagtataa ttattgattc 51240
cacggaagaa ctaccaacag ttactccaat tacaacaaca tataattata ctatcgatga 51300
tagcactact gaagaactac aagtgactcc tcatatggat ctccatcgat gatacatgta 51360
ttaaaatact ttccgaataa gtcttttaaa tattgtatta attatgaaaa actatgctat 51420
gcgagtatga tacgatacta gattttatct ctagcgagag atgtcgttag aatcatttat 51480
caacgaatat cgataacatg tgtcatttat acgttaaagt ctgtccgtct tctctattgt 51540
ttagactgtt tgtagaatgc tgtgatataa acaaactagt agacacaaat atttaactca 51600
tgatgaagtt gagaatgata tgctttagct aatataaaaa tatattaatc cactatatat 51660
tctagacttg atttaaaacc gataaactac tactacgtac tgtataagtt aggagcagac 51720
cctaattatg tagatgatag aggtaatact tctgcatcta tatgtccact tatgagaaaa 51780
cgtcatttaa taagatgcat cgtgaaaaga aatttattaa agagttggta aaatatgaaa 51840
ccgaaagtaa ataatatagg aaatacacct ctacataact acgtatctca atatgatatc 51900
actctcattc ctcatccaca acccattaaa aaatggaaat taaagccctc tattagcata 51960
aacggctaca ggtctacctt tacaatggcc tttccttgtg cccagttcag accctgtcat 52020
tgccacgcta ctaaggactc cctgaatacc gtggccgacg tcagacattg tctgactgaa 52080
tacatcctgt gggtttctca tagatggacc catagagaaa gcgcagggtc tctctacagg 52140
cttctcatct ctttcagaac tgatgcaacg gagctctttg gtggtgagtt gaaggattca 52200
cttccgtgga gatcattaaa tgactccatg aaaaccgccg aagaacttcg tgcaatcatt 52260
ggactttgta ctcaatcagc tatcgtctct ggaagagtct tcaacgataa gtatatcgac 52320
atactactta tgctgcgaaa gattctgaac gagaacgact atctcaccct cttggatcat 52380
atccgcactg ctaaatacta aatctccttc atgctctctc actacacttt ttatcatctt 52440
atgaggaata attagcacca gaatagctat ggattgcaca tgtattctat gtcgtctact 52500
ggatgaagat gtgacgtaca aaaaaataaa actagaaatt gaaacgtgtc acaacttatc 52560
aaaacatata gatagacgag gaaacaatgc gctacattgt tacgtctcca ataaatgcga 52620
tacagacatt aagattgttc gactgttact ctctcgcgga gtcgagagac tttgtagaaa 52680
caacgaagga ttaactccgc taggagcata cagtaagcat agatacgtaa aatctcagat 52740
tgtgcatcta ctgatatcca gctattcgaa ttcctctaac gaactcaagt cgaatataaa 52800
tgatttcgac ttacgtctgc taaaatacct aattgtggat aaacggatac gtccgtccaa 52860
gaatacgaat tatgcaatca atggtctcgg attggtggat atatacgtaa cgacgcctaa 52920
tccgagacca gaagtattgc tatggcttct taaatcagaa tgttacagca ccggttacgt 52980
atttcgtacc tgtatgtaca acagtgatat gtgtaagaac tctcttcatt actatatatc 53040
gtctcataga gaatctctat ccaaggatgt aattaaatgt ttgatcgata acaatgtttc 53100
catccaatac tactggtctt gctcaaccat agatatagag attattaata aaggatgtgg 53160
acacgtgtag agtatacgac gtcagcccta tattagaggc gtattatcta aacaagcgat 53220
ttagagtaac cccatataat gtagacatgg aaatcgttaa tcttcttatt gagagacgtc 53280
atactcttgt cgacgtaatg cgtagtatta cttcgtacga ttccagagaa tataaccact 53340
acatcatcga taacattcta aagagattta gacaacagga tgaatccatc gtacaagcca 53400
tactgataaa ctacttacat tacggcgata tggtaagtat acctatcatt caatgcatgt 53460
tggataagac gacggacaac aactttgtta ataataatct cgtcgatgta aacgtcgtaa 53520
ggtttatcgt ggaaaatatg gacacgcggc tgtaaatcac atatctaaca atggccgtct 53580
atgtatgtac ggtctgatat tatcgagatt taataattgc gggtatcact gttatgaaga 53640
tgtatttgat atactaagca agtacatgga tgatatagat atgatcgata actctactat 53700
attacgcggt cgatgtcaat aatatacaat ttgcaaagcg gttattggaa tatggagcga 53760
gtgtcacgct cgataatcaa tacggccatc cagaaaagca gttaccaaag agaagctagt 53820
tgatttatta ctgagttacc atcccactct agagactatg attgacgcat ttaatagaga 53880
tatacgctat ctatatcctg aaccattatt cgcctgtatc agatacgcct taatcctaga 53940
tgatgatttt ccttctaaag taagtatgat atcgccggtc gtcataagga actaaagcgc 54000
tatagagcag acattaatag aatgaagaat gcctacatat caggcgtctc catgtttgat 54060
atattattta aacgaagcaa acgccacaga ttgagatacg caaagaacaa tgagaggatc 54120
gactccatta aataatttat catggagtga taatgtcctg tttccatggc atattacaaa 54180
atcgattccg tccaagatga taaaaacatt taccggcatc ataaacacgg agtttatttt 54240
atatgtctcg cataaacatt actaaaaaaa tatattgttc ggttttcttt cacatcttta 54300
attatgaaaa agtaaatcat tatgagatgg acgcatcgtt cgcgacagta tgtggtacat 54360
acctaacgta tttatggacg acggtaagaa tgaaggtcac gtttctgtca acaatgtcga 54420
cgcgatcgtg taacacgact cacaatagaa tctgtgaatg ctctcccgat catggatgca 54480
aggcatgtgt ttcccaaaca aaatgtggaa taggatacgg agtatccgga gacgtcatct 54540
gttctccgtg tggtctcgga acatattctc acaccgtctc ttccgcagat aaatgcgaac 54600
ccgtacccag aaataccttt aactatatcg atgtggaaat taacctgtat ccagttaacg 54660
acacatcgtg tactcggacg accactaccg gtctcagcga atccatctca acgtcggaac 54720
taactattac tatgaatcat aaagactgcg atcccgtctt cttaataagg tagcgacttc 54780
aggtttcttt acaggagaaa ggtgtgcact ctgaatttcg agattaaatg caataacaaa 54840
gattcttcct ccaaacagtt aacgaaagca aagaatgata ctatcatgcc gcattcggag 54900
acagtaactc tagcgtcgac atctatatac tatatagtaa taccaatact caagactacg 54960
aaactgatac aatctcttat catgtgggta atgtagccat atgcccggta gttgcgatat 55020
acataaactg atcactaatt ccaaacccac ccgcttttta tagtaagttt ttcacccata 55080
aatacaataa ttaatttctc gtaaaagtag aaaatatatt ctaatttatt gcacggtaag 55140
gaagtagaat cataaagaac agtactcaat caatagcaat catgaaacaa tatatcgtac 55200
tggcatgcat gtgcctgcca gtcttcagca atcatcctca tcgtgtacgg aagaagaaaa 55260
caaacatcat atgggaatcg atgttattat caaagtcaca aagcaagacc aaacaccgac 55320
cgatgataag atttgccaat ccgtaacgga aattacagag tccgagtcag atccagatcc 55380
cgaggtggaa tcagtcgagg atgtagatcc tcctaccact tattactcca tcatcggtgg 55440
aggtctgaga atgaactttg gattcaccaa atgtcctcag attaaatcca tctcagaatc 55500
cgctgatgga aagactgtga ggtgtctatc gacatcagat gtagcgaaga agagaaagac 55560
agcgacatca agacccatcc agtactcggg tctaacatct ctcataagaa agtgagttac 55620
gaagatatca tcggttcaac gatcgtcgat acaaaatgtg tcaagaatct agagtttagc 55680
gttcgtatcg gagacatgtg caaggaatca tctgaacttg aggtcaagta tgtcgacgga 55740
tcggcatctg aaggtgcaac cgatgatact tcactcatcg attcaacaaa actcaaagcg 55800
tgtgtctgaa tcgataactc tattcatctg aaattggatg agtagggtta atcgaacgat 55860
tcaggcacac cacgaattaa aaaagtgtac cggacactat attccggttt gcaaaacaaa 55920
aagttacctc tcgcgacttc ttctttttct gtctcaatag tgtgatacga ttatgacact 55980
attcctattt cctttcaggg tatcacaaaa atattaaacc tctttctgat ggtctcatac 56040
aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaatatt tttattctct 56100
ttctctcttt gatggtctca taaaatattt ttattctctt tctctctttg atggtctcat 56160
aaaaaatatt tttattctct ttctctcttt gatggtctca taaaatattt ttattctctt 56220
tctctctttg atggtctcat aaaaaatatt tttattctct ttctctcttt gatggtctca 56280
taaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc tctttctctc 56340
ttcaatggag tcataaaata tttttattct ctttctctct tcgatggtct cacaaaaata 56400
ttaaacctct ttctgatggt gtcactaaaa tatttttatt ctctttctct cttcaatgga 56460
gtcataaaat atttttattc tctttctctc tttgatggtc tcacaaaaat atttttattc 56520
tctttctctc tttgatggtc tcacaaaaat atttttattc tctttctctc tttgatggtc 56580
tcacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 56640
aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 56700
ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 56760
tctctttctc tctttgatgg tctcataaaa aatattaaac ctctttctga tggtgtcact 56820
aaaatatttt tattctcatt ctctcttcaa tggagtcata aaatattttt attctctttc 56880
tctcttcgat ggtctcacaa aaatattaaa cctctttctg atggtgtcac taaaatattt 56940
ttattctcat tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga 57000
tggtctcaca aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca 57060
ttctctcttc aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat 57120
aaaaaaagtt ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa 57180
tattaaacct ctttctgatg gtgtcactaa aatattttta ttctctttct ctcttcaatg 57240
gagtcataaa atatttttat tctctttctc tcttcgatgg tctcacaaaa atattaaacc 57300
tctttctgat ggtgtcacta aaatattttt attctcattc tctcttcaat ggagtcataa 57360
aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 57420
tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 57480
ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 57540
ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 57600
ttgatggtct cataaaaaat attaaacctc tttctgatgg tgtcactaaa atatttttat 57660
tctcattctc tcttcaatgg agtcataaaa tatttttatt ctctttctct cttcgatggt 57720
ctcacaaaaa tattaaacct ctttctgatg gtgtcactaa aatattttta ttctcattct 57780
ctcttcaatg gagtcataaa atatttttat tctctttctc tctttgatgg tctcataaaa 57840
aaagttttac aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 57900
ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 57960
aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 58020
ttttattctc tttctctctt tgatggtctc acaaaaatat taaacctctt tctgatggag 58080
tcgtaaaaaa gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt 58140
ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt 58200
aaacctcttt ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca 58260
ctaaaatatt ttttattctc tttctgatgc atcaactatt tcttaaacaa taacgtccaa 58320
caacatatac tcgtcgagct tatcaacatc ccctatgccc atctaggtta ccagacaatt 58380
gtatatcata aaataatgtt tataattttt acaaaaatat ttttattctc tttctctctt 58440
tgatggtctc ataaaaaaag ttttacaaaa atatttttat tctctttctc tctttgatgg 58500
tctcataaaa aatattaaac ctctttctga tggtgtcact aaaatatttt tattctcatt 58560
ctctcttcaa tggagtcata aaatattttt attctctttc tctcttcgat ggtctcacaa 58620
aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctcat tctctcttca 58680
atggagtcat aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt 58740
tacaaaaata tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa 58800
aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 58860
tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 58920
ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 58980
ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 59040
ttgatggtct cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg 59100
gtctcataaa aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctctt 59160
tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga tggtctcaca 59220
aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca ttctctcttc 59280
aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 59340
ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 59400
aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 59460
ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 59520
tctctttctc tctttgatgg tctcataaaa aaagttttac aaaaatattt ttattctctt 59580
tctctctttg atggtctcat aaaaaatatt aaacctcttt ctgatggtgt cactaaaata 59640
tttttattct ctttctctct tcaatggagt cataaaatat ttttattctc tttctctctt 59700
cgatggtctc acaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc 59760
tctttctctc ttcaatggag tcataaaata tttttattct ctttctctct ttgatggtct 59820
cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg gtctcataaa 59880
aaaagtttta caaaaatatt tttattctct ttctctcttt gatggtctca taaaaaaagt 59940
tttacaaaaa tatttttatt ctctttctct ctttgatggt ctcataaaaa aagttttaca 60000
aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt tacaaaaata 60060
tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa aatattttta 60120
ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt tttattctct 60180
ttctctcttt gatggtctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60240
atttttattc tcattttctc tttctctctt caatggagtc ataaaatatt tttattctct 60300
ttctctcttt gatggtctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60360
atttttattc tcattctctc ttcaatggag tcataaaaaa gttttatctc tttctctctt 60420
cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc 60480
tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatgcat caactatttc 60540
ttaaacaata acgtccaaca acatatactc atcccctatg cccatctagg ttaccagaca 60600
attgtatatc ataaaataat gtttataatt tacacgttaa aatcatataa taaaacgtag 60660
atcgtataat attttttggt atataaatga tctagtaaaa tccatgtagg ggatactgct 60720
cacatttttt ctttggtaca aaatttcaca caagttttta tacagacaaa ttcttgtcca 60780
tatattttaa aacattgact tttgtactaa gaaaaatatc tagactaact atctctttct 60840
ctttctctct tcgatggtct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 60900
tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 60960
ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 61020
agttttatct ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag 61080
tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat taaacctctt 61140
tctgatggtg tcactaaaat atttttattc tctttctctc ttcgatggtc tcacaaaaat 61200
attaaacctc tttctgatgg agtcgtaaaa aagttttatc tctttctcct tcgatggtct 61260
cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 61320
tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 61380
ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa 61440
gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt ctgatggagt 61500
cgtaaaaaag ttttatctct ttctccttcg atggtctcac aaaaatatta aacctctttc 61560
tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac aaaaatatta 61620
aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac 61680
aaaaatatta aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctccttcga 61740
tggtctcaca aaaatattaa acctctttct gatggtctct ataaagcgat tgatttttct 61800
taccctctag agtttcctac ggtcgttggt cacacatttt tttctagaca ctaaataaat 61860
agtaagatta aattaattat aaaattatgt atataatatt aattataaaa ttatgtatat 61920
gatttactaa ctttagttag ataaattaat aatacataaa ttttagtata ttaatattat 61980
aaattaataa tacataaatt ttagtatatt aatattatat tttaaatatt tatttagtgt 62040
ctagaaaaaa aggccggcct agcaggcc 62068
<210> 15
<211> 62068
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA F3
<400> 15
ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60
attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120
aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180
gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccgggt 240
attaataata tctatatttc cagcgttaag tgtaacatta aacagtttta attcacgtga 300
cgtggtatca attaaataat taatgcccaa tttggatata gcagcctgaa gctcatcttg 360
tttagttacg gatcctaatg agttattaag caatatatcg aacggatgaa cgaaggttgt 420
tttaagttgg tcacatactt tgtaatctag acatagatgc ggaagaacgg tagaaactat 480
acgaaataaa tattcagagt cctctaattg atcaagagta actattgact taataggcat 540
catttattta gtattaaatg acgaccgtac cagtgacgga tatacaaaac gatttaatta 600
cagagttttc agaagataat tatccatcta acaaaaatta tgaaataact cttcgtcaaa 660
tgtctattct aactcacgtt aacaacgtgg tagatagaga acataatgcc gccgtagtgt 720
catctccaga ggaaatatcc tcacaactta atgaagatct atttccagat gatgattctc 780
cggccactat tatcgaacga gtacaacctc atactactat tattgacgat actccacctc 840
ctacgtttcg tagagagtta ttgatatcgg aacaacgtca acaacgagaa aaaagattta 900
atattacagt atcgaaaaat gctgaagcaa taatggaatc tagatctatg atatcttcta 960
tgccaacaca aacaccatcc ttgggagtag tttatgataa agataaaaga attcagatgt 1020
tggaggatga agtggttaat cttagaaatc aacgatctaa tacaaaatca tctgataatt 1080
tagataattt taccagaata ctatttggta agactccgta taaatcaaca gaagttaata 1140
agcgtatagc catcgttaat tatgcaaatt tgaacgggtc tcccttatca gtcgaggact 1200
tggatgtttg ttcagaggat gaaatagata gaatctataa aacgattaaa caatatcacg 1260
aaagtagaaa acgaaaaatt atcgtcacta acgtgattat tattgtcata aatattatcg 1320
agcaagcatt gctaaaactc ggatttgaag aaatcaaagg actgagtacc gatatcactt 1380
cagaaattat cgatgtggag atcggagatg actgcgatgc tgtagcatca aaactaggaa 1440
tcggtaacag tccggttctt aatattgtat tgtttatact caagatattc gttaaacgaa 1500
ttaaaattat ttaatttaat acattcccat atccagacaa caatcgtctg gattaatctg 1560
ttcctgtcgt ctcataccgg acgacatatt aatcttttta ttagtaggca tctttttaga 1620
tggtttcttt ttcccagcat taactgagtc gatacctaga agatcgtgat tgatctctcc 1680
gaccattcca cgaacttcta attggccgtc tctgacggta ccataaacta ttttaccagc 1740
attagtaaca gcttggacaa tctgaccatc catcgcattg tacgatgtag tagtaactgt 1800
tgttctacgt ctaggagcac cagaagtatt tttggagccc ttggatgttg atgtagaaga 1860
agacgaggat tttgattttg gtttacatgt aatacatttt gtatcacatg cgccggcagt 1920
cacatctgtt tgagaattaa gattattgtt gcctcctttg acggctgcat ctccaccgat 1980
ttgcgctagt agatttttaa gctgtggtgt aatcttatta actgtttcga tataatcatc 2040
gtaactgctt ctaacggcta aatttttttt atccgccatt tagaagctaa aaatattttt 2100
atttatgcag aagatttaac tagattatac aatgaactaa tatgatcctt ttccagatta 2160
tttacaaact tggtattttt tggttctgga ggaggcgaat ttaaattcgg acttggattt 2220
ggattttgtg ggttcttgat cttattatac agcgcatata ggatggcgac ggtaactgct 2280
acgcaaatac cgatcaacaa aagaatacca atcatttatt gacaataact tcactattga 2340
tcaagtatgc aatatatcat cttttcacta aataagtagt aataatgatt caacaatgtc 2400
gagatatatg gacgataata atttagttca tggaaatatc gctatgattg gtatgaatga 2460
ctccgctaac tctgtggggc gcgcagtgct ttccccacat agaataaatt agcattccga 2520
ctgtgataat aataccaagt ataaacgcca taatactcaa tactttccat gtacgagtgg 2580
gactggtaga cttactaaag tcaataaagg cgaagataca cgaaagaatc aaaagaatga 2640
ttccagcgat tagcacgccg gaaaaataat ttccaatcat aagcatcata tccatttaac 2700
taataaaaat tttaaatcgc cgaatgaaca aagtggaata taaaccatat aaaaacaata 2760
gtttgtactg caaaaataat atctattttt gttttcgaag atatggtaaa attaaatagt 2820
agtacacagc atgttataac taacagcagc aacggctcgt aattacttat catttactag 2880
acgaaaaggt ggtgggatat tttcttgctc aaataatacg aatatatcac ccatccattt 2940
tatgcgatgt ttatatactc taatctttaa tagatctata gacgacgggt ttaccaacaa 3000
tatagatttt atcgattcat ctaatttaaa cccttcctta aacgtgaatg atctattatc 3060
tggcataacg atgactctac ccgatgaatc ggacaatgta ctgggccatg tagaataaat 3120
tatcaacgaa ttatcgtcta cgaacattta tatcatttgt tttaatttta gtacgcgaat 3180
aaatagatat aaaatagaaa ataacagata ttacaaccaa tgttatggcc gcgcccaacc 3240
aggtaggcag ttttatttta tcttttacta caggttctcc tggatgtacg tcaccaacgg 3300
cggacgtagt tctagtacaa ttagacgtaa gttccgcttg ggaatttttt aacgctaaag 3360
agttaacgtt aatcgtgcac ccaacgtatt tacatctagt tctttgaaca tcttgattat 3420
aatataacca ttttctatct ctagattcgt cggtgcactc atgtaaccaa cataccctag 3480
gtcctaaata tttatctccg gaattagatt ttggataatt cgcgcaccaa caatttctat 3540
ttcctttatg atcgttacaa aagacgtata atgccgtatc cccaaaagta aaataatcag 3600
gacgaataat tctaataaac tcagaacaat atctcgcatc catatgtttg gagcaaatat 3660
cggaataagt agacatagcc ggtttccgtt ttgcacgtaa ccattctaaa caattggggt 3720
ttccaggatc gtttctacaa aatccagtca tgaaatcatc acaatgttct gtcttgtaat 3780
tattattaaa tatttttgga cagtgtttgg tatttgtctt agaacaacat tttgccacgc 3840
tatcactatc gcccaggaga taatcctttt ttataaaatg acatcgttgc ccggatgcta 3900
tataatcagt agcgtgtttt aaatccttaa tatattcagg agttacctcg ttctgataat 3960
agattaatga tccaggacga aatttgaaag aactacatgg ttctccatga attaatacat 4020
attgtttagc aaattcagga actataaaac tactacaatg atctatcgac ataccatcta 4080
tcaaacaaaa cttgggttta atttctcccg gagatgtttc ataatagtac gtataacttt 4140
cttctgcaaa cttaacagct ctattatatt caggataatt aaaacctaat tccatatatt 4200
tgtctcgtat atctgctatt cctggtgcta ttttgattct attaagagta acggctgccc 4260
ccatttttaa taatcgtcag tatttaaact gttaaatgtt ggtatatcaa catttacctt 4320
atttcccgca gtataaggtt tgttgcaggt atactgttca ggaatggtta catttatact 4380
ttttctatag tcctgtcttt cgatgttcat cacatatgca aagaacagaa taaacaaaat 4440
aatgtaagaa ataatattaa atatctgtga attcgtaaat acattgattg ccataataat 4500
tacagcagct acaatacata caatagacat tcccacagtg ttgccattac ctccacgata 4560
catttgagtt actaagcaat aggtaataac taagctagta agaggcaata gaaaagatga 4620
gataaatatc atcaatatag agattagagg agggctatat agagccaaga cgaacaaaat 4680
caaaccgagt aacgttctaa catcattatt tttgaagatt cccaaataat cattcattcc 4740
tccataatcg ttttgcatca tacctccatc tttaggcata aacgattgct gctgttcctc 4800
tgtaaataaa tctttatcaa gcactccagc acccgcagag aagtcgtcaa gcatattgta 4860
atatcttaaa taactcattt atatattaaa aaatgtcact attaaagatg gagtataatc 4920
tttatgccga actaaaaaaa atgacttgtg gtcaacccct aagtcttttt aacgaagacg 4980
gggatttcgt agaagttgaa ccgggatcat cctttaagtt tctgatacct aagggatttt 5040
acgcctctcc ttccgtaaag acgagtctag tatttgaaac attaacaacg accgataata 5100
aaattactag tatcaatcca acaaatgcgc caaagttata tcctcttcaa cgcaaagtcg 5160
tatctgaagt agtttctaat atgaggaaaa tgatcgaatc aaaacgtcct ctatacatca 5220
ctcttcactt ggcgtgtgga tttggtaaga ctattaccac gtgttatctt atggctacac 5280
acggtagaaa aaccgtcatt tgcgtaccca ataaaatgtt aatacatcaa tggaagacac 5340
aggtagaggc agtcggattg gaacataaga tatccataga tggagtaagt agtctattaa 5400
aggaactaaa gactcaaagt ccggatgtat taatagtagt cagtagacat ctgacaaacg 5460
atgccttttg taaatatatc aataagcatt atgatttgtt catcttggat gaatcacata 5520
cgtataatct gatgaacaat acagcagtta caagattttt agcgtattat cctccgatga 5580
tgtgttattt tttaactgct acacctagac catctaacag aatttattgt aacagtatta 5640
ttaatattgc caagttatcc gatctaaaaa aaactatcta tgcagtagat agtttttttg 5700
agccatattc cacagataat attagacata tgataaaacg attagatgga ccatctaata 5760
aatatcatat atataccgag aagttattat ctgtagacga gcctagaaat caacttattc 5820
ttaataccct ggtagaagaa ttcaagtcag gaactattaa tcgcatttta gttattacta 5880
aactacgtga acatatggta ttcttctaca aacgattatt agattttttc ggatcagagg 5940
ttgtatttat aggagacgcc caaaatagac gtactccaga tatggtcaaa tcaatcaagg 6000
aactaaatag atttatattc gtatccacct tattttattc cggtactggt ttagatattc 6060
ctagtttgga ttctttgttc atttgctcgg cagtaatcaa caatatgcaa atagagcaat 6120
tactagggag ggtatgtcga gaaacagaac tattagatag gacggtatat gtatttccta 6180
gcacatccat caaagaaata aagtacatga taggaaattt cgttcaacga attattagtc 6240
tgtctgtaga taaactagga tttaaacaaa aaagttatcg gaaacatcaa gaatccgatc 6300
ccacttctgt atgtacaaca tcctccagag aagaacgtgt attaaataga atatttaact 6360
cgcaaaatcg ttaagaagtt taagcgacga tccgcatgct gcgcaggcca gtgtattacc 6420
cctcatagta ttaatataat ccaatgatac ttttgtgatg tcggaaatct taaccaattt 6480
agactgacag gcagaacacg tcatgcaatc atcatcgtca tcgataactg tagtcttggg 6540
cttctttttg cggctcttca ttccggaacg cacattggtg ctatccattt aggtagtaaa 6600
aaataagtca gaatatgccc tatagcacga tcgtgcaaaa cctggtatat cgtctctatc 6660
tttatcacaa tatagtgtat cgacatcttt attattattg acctcgttta tcttggaaca 6720
tggaatggga acatttttgt tatcaacggc cacctttgcc ttaattccag atgttgtaaa 6780
attataacta aacagtctat catcgacaca aatgaaattc ttgtttagac gtttgtagtt 6840
tacgtatgcg gctcgttcgc gtctcatttt ttcagatatt gcaggtacta taatattaaa 6900
aataagaatg aaataacata ggattaaaaa taaagttatc atgacttcta gcgctgattt 6960
aactaactta aaagaattac ttagtctgta caaaagtttg aaattttcag attctgcggc 7020
tatagaaaag tataattctt tggtagaatg gggaacatct acttactgga aaataggcgt 7080
gcaaaaggta gctaatgtcg agacgtcaat atctgattat tatgatgagg taaaaaataa 7140
accgtttaat attgatccgg gctattacat tttcttaccg gtatattttg ggagcgtctt 7200
tatttattcg aagggtaaaa atatggtaga acttggatct ggaaactctt ttcaaatacc 7260
agatgatatg cgaagtgcgt gtaacaaagt attagacagc gataacggaa tagactttct 7320
gagatttgtt ttgttaaaca atagatggat aatggaagat gctatatcaa aatatcagtc 7380
tccagttaat atatttaaac tagctagtga gtacggatta aacataccca aatatttaga 7440
aattgaaata gaggaagaca cattatttga cgacgagtta tactctatta tagaacgctc 7500
tttcgatgat aaatttccaa aaatatccat atcgtatatt aagttgggag aacttaggcg 7560
gcaagttgta gactttttca aattctcatt catgtatatt gagtccatca aggtagatcg 7620
tataggagat aatattttta ttcctagcgt tataacaaaa tcaggaaaaa agatattagt 7680
aaaagatgta gaccatttaa tacgatccaa ggttagagaa catacatttg taaaagtaaa 7740
aaagaaaaac acattttcca ttttatacga ctatgatgga aacggaacag aaactagagg 7800
agaagtaata aaacgaatta tagacactat aggacgagac tattatgtta acggaaagta 7860
tttctctaag gttggtagtg caggcttaaa gcaattgact aataaattag atattaatga 7920
gtgcgcaact gtcgatgagt tagttgatga gattaataaa tccggaactg taaaacgaaa 7980
aataaaaaac caatcagcat ttgatttaag cagagaatgt ttgggatatc cagaagcgga 8040
ttttataacg ttagttaata acatgcggtt caaaatagaa aattgtaagg ttgtaaattt 8100
caatattgaa aatactaatt gtttaaataa cccgagtatt gagactatat atggaaactt 8160
taaccagttc gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat tattcgagtg 8220
aaataatatg cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt ttagaagtca 8280
aggataactc cgttagggta ttggatatat caaaattaga ctggagttct gattgggaaa 8340
ggcacatagc taaagatttg tcacaatatg aatacactac agttcttcta gaacgtcagc 8400
ctagaaggtc gccgtacgtc aaatttatct attttattaa aggcttttta tatcatacat 8460
cggctgccaa agttatttgc gtctcgcctg tcatgtctgg taattcatat agagatcgaa 8520
aaaagagatc ggtcgaagca tttcttgatt ggatggacac attcggattg cgagactccg 8580
ttccggatag acgcaaatta gacgatgtag cggatagttt caatttggct atgagatacg 8640
tattagataa atggaatact aattatacac cttataatag gtgtaaatct agaaattaca 8700
taaaaaaaat gtaataacgt tagtaacgcc attatggata atctatttac ctttctacat 8760
gaaatagaag atagatatgc cagaactatt tttaactttc atctaataag ttgcgatgaa 8820
ataggagata tatatggtct tatgaaagaa cgcatttcct cagaggatat gtttgataat 8880
atagtgtata ataaagatat acatcatgcc attaagaaac tagtgtattg cgacatccaa 8940
cttactaaac acattattaa tcagaatacg tatccggtat ttaacgattc ttcacaagtg 9000
aaatgttgtc attatttcga tataaactca gataatagca atattagctc tcgtacagta 9060
gagatatttg agagggaaaa gtcatctctt gtatcatata ttaaaactac caataagaag 9120
agaaaggtca attatgggga aataaagaaa actgtacatg gaggcactaa tgcaaattac 9180
ttttccggta aaaagtctga tgagtatctg agcactacag tcaggtccaa cattaatcaa 9240
ccttggatca aaaccatttc taagagaatg agagtagata tcattaatca ctctatagta 9300
acgcgtggaa aaagctctat attacaaact atagaaatta tttttactaa tagaacatgt 9360
gtgaaaatat tcaaggattc tactatgcac attattctat ccaaggacaa ggatgaaaag 9420
gggtgtatac acatgattga caaattattc tatgtctatt ataatttatt tctgttgttc 9480
gaggatatca tccaaaacga gtactttaaa gaagtagcta atgttgtaaa ccacgtactc 9540
acggctacgg cattagatga gaaattattc ctaattaaga aaatggctga acacgatgtt 9600
tatggagtta gcaatttcaa aatagggatg tttaacctga catttattaa gtcgttggat 9660
cataccgttt tcccctctct gttagatgag gatagcaaaa taaagttttt taaggggaaa 9720
aagctcaata ttgtagcatt acgatctctg gaggattgta taaattacgt gactaaatcc 9780
gagaatatga tagaaatgat gaaggaaaga tcgactattt taaatagcat agatatagaa 9840
acggaatcgg tagatcgtct aaaagaattg cttctaaaat gaaaaaaaaa cactaattca 9900
gaaatggatc aacgactcgg atataagttt ttggtgcctg atcctaaagc cggagttttt 9960
tatagaccgt tacatttcca atatgtatcg tattctaatt ttatattgca tcgattgcat 10020
gaaatcttga ccgtcaagcg gccactctta tcgtttaaga ataatacaga acgaattatg 10080
atagaaatta gcaatgttaa agtgactcct ccagattact cacctataat cgcgagtatt 10140
aaaggtaaga gttatgacgc attagccacg ttcactgtaa atatctttaa agaggtaatg 10200
accaaagagg gtatatccat cactaaaata agtagttatg agggaaaaga ttctcatttg 10260
ataaaaattc cgctactaat aggatacggg aataaaaatc cacttgatac agccaagtat 10320
cttgttccta atgtcatagg tggagtcttt atcaataaac aatctgtcga aaaagtagga 10380
attaatctag tagaaaagat tacaacatgg ccaaaattta gggttgttaa gccaaactca 10440
ttcactttct cgttttcctc cgtatcccct cctaatgtat taccgacaag atatcgccat 10500
tacaagatat ctctggatat atcacaattg gaagcgttga atatatcatc gacaaagaca 10560
tttataacgg tcaatattgt tttgctgtct caatatttat ctagagtgag tctagaattc 10620
attagacgta gtttatcata cgatatgcct ccagaagttg tctatctagt aaacgcgata 10680
atagatagtg ctaaacgaat tactgaatct attactgact ttaatattga tacatacatt 10740
aatgacctgg tggaagctga acacattaaa caaaaatctc agttaacgat caacgagttc 10800
aaatatgaaa tgctgcataa ctttttacct catatgaact atacacccga tcaactaaag 10860
ggattttata tgatatcttt actaagaaag tttctctact gtatctacca cacttctaga 10920
tatccagata gagattcgat ggtttgtcat cgcatcctaa cgtacggcaa atattttgag 10980
acgttggcac atgatgaatt agagaattac ataggcaaca tccgaaacga tatcatgaac 11040
aatcacaaga acagaggcac ttacgcggta aacattcatg tactaacaac tcctggactt 11100
aatcatgcat tttctagtct attgagtgga aagttcaaaa agtcagacgg tagttatcga 11160
acacatcctc actattcatg gatgcagaat atttctattc ctaggagtgt tggattttat 11220
ccggatcaag taaagatttc aaagatgttt tctgtcagaa aataccatcc aagtcaatat 11280
ctttactttt gttcatcgga cgttccggaa agaggtcctc aggtaggttt agtatctcaa 11340
ttgtctgtct tgagttccat tacaaatata ctaacgtctg agtatttgga tttggaaaag 11400
aaaatttgtg agtatatcag atcatattat aaagatgata taagttactt tgaaacagga 11460
tttccaatca ctatagaaaa tgctctagtc gcatctctta atccaaatat gatatgtgat 11520
tttgtaactg actttagacg tagaaaacgg atgggattct tcggtaactt ggaggtaggt 11580
attactttag ttagggatca catgaatgaa attcgcatta atattggagc gggaagatta 11640
gtcagaccat tcttggttgt ggataacgga gagctcatga tggatgtgtg tccggagtta 11700
gaaagcagat tagacgacat gacattctct gacattcaga aagagtttcc gcatgtcatc 11760
gaaatggtag atatagaaca atttactttt agtaacgtat gtgaatcggt tcaaaaattt 11820
agaatgatgt caaaggatga aagaaagcaa tacgatttat gtgactttcc tgccgaattt 11880
agagatggat atgtagcatc ttcactagtg ggaatcaatc acaattctgg acccagagct 11940
attcttggat gtgctcaagc taaacaagct atctcttgtc tgagctcgga tatacgaaat 12000
aaaatagaca atggaattca tttgatgtat ccagagaggc caatcgtgat tagtaaggct 12060
ttagaaactt caaagattgc ggctaattgc ttcggccaac atgttactat agcattaatg 12120
tcgtacaaag gtatcaatca agaggatgga attatcatca aaaaacaatt tattcagaga 12180
ggcggtctcg atattgttac agccaagaaa catcaagtag aaattccgtt ggaaaacttt 12240
aataacaaag aaagagatag gtctaacgcc tattcaaaat tagaaagtaa tggattagtt 12300
agactgaatg ctttcttgga atccggagac gctatagcac gaaatatctc atcaagaact 12360
cttgaagatg attttgctag agataatcag attagctttg atgtttccga aaaatatacc 12420
gatatgtaca aatctcgcgt tgaacgagta caagtagaac ttactgacaa agttaaggta 12480
cgagtattaa ccatgaaaga aagaagaccc attctaggag acaaatttac cactagaacg 12540
agtcaaaagg gaacagtcgc gtatatcgcg gatgaaacgg aacttccata cgatgaaaat 12600
ggtatcacac cagatgtcat tattaattct acatccatct tctctagaaa aactatatct 12660
atgttgatag aggttatttt aacagccgca tattctgcta agccgtacaa caataaggga 12720
gaaaaccgac ctgtctgttt tcctagtagt aacgaaacat ccatcgatac atatatgcaa 12780
ttcgctaaac aatgttatga gcattcaaat ccgaaattgt ctgatgaaga attatcggat 12840
aaaatctttt gtgaaaagat tctctatgat cctgaaacgg ataagcctta tgcatccaaa 12900
gtattttttg gaccaattta ttacttgcgt ctgaggcatt taactcagga caaggcaacc 12960
gttagatgta gaggtaaaaa gacgaagctc attagacagg cgaatgaggg acgaaaacgt 13020
ggaggaggta tcaagttcgg agaaatggag agagactgtt taatagcgca tggtgcagcc 13080
aatactatta cagaagtttt gaaagattcg gaagaagatt atcaagatgt gtatgtttgt 13140
gaaaattgtg gagacatagc agcacaaatc aagggtatta atacatgtct tagatgttca 13200
aaacttaatc tctctcctct cttaacaaaa attgatacca cgcacgtatc taaagtattt 13260
cttactcaaa tgaacgccag aggcgtaaaa gttaaattag atttcgaacg aaggcctcct 13320
tcgttttata aaccattaga taaagttgat ctcaaaccgt cttttctggt gtaatattct 13380
agtttggtag tagatacata tcaatatcat caaattcgag atccgaatta taaaatgggc 13440
gtggattgtt aactatagaa tcggacgtct gatattcgaa aatctgtgga gttttaggtt 13500
ttggtggagg tgtaactgct acttgggata ctgaagtctg atattcagaa agctggggga 13560
tgttctggtt cgacatccac cgatggtgtc acatcactaa tcggttcggt aacgtctgtg 13620
gacgatggag gcaccacttc tacaggttct ggttctttat cctcagtcat caacggagct 13680
acttcaatgc gaggaaatgt ataatttggt aatggtttct catgtggatc tgaagaagag 13740
gtaagatatc tactagaaag ataccgatca cgttctagtt ctcttttgta gaacttaact 13800
ttttctttct ccgcatctag ttgatattcc aacctcttca cgttcgcatg ggttacctcc 13860
gcagttttta cgagcgattt cacgttcagc cttcatgcgt cttatagcat gaattcgctt 13920
atcgttatcg ggtttagctt ctgtcacctt agcaattcct tttttattaa actctacata 13980
atcatatcca tttctattgt ttgttctaat ataaacgagt atagcatcat tgctaaattt 14040
ttcaatagta tcgaaaacag aatatcctaa accatataat atatattcag gaacactcaa 14100
actaaatgtc caggattctc ctaaatacgt aaactttaat agtgcgaaat cattcaaaaa 14160
tctaccactt atagatagat agatagtaca taaatgcgta tagtagtcta cctatctctt 14220
tattatgaaa accggcatta cgatcatata tgtcgtgata tacctgtgat ccgtttacgt 14280
taaaccataa atacatgggt gatcctataa acatgaattt atttctaatt ctcagagcta 14340
tagttaattg accgtgtaat atttgcttac atgcatactt gatacgatca ttaataagat 14400
ttttatcatt gctcgttatt tcagaatcgt atatataagg agtaccatcg tgattcttac 14460
cagatattat acaaaatact atatataaaa tatattgacc cacgttagta atcatgtaaa 14520
tgtttaacgt tttaaatttt gtattcaatg atccattatc atacgctagc atggtcttat 14580
gatattcatt ctttaaaata taatattgtg ttagccattg cattggggct cctaatggag 14640
attttttatt ctcatccatt ttaggatagg ctttcataaa gtccctaata acttcgtgaa 14700
taatgtttct atgttttcta ctgatgcatg tatttgcttc gattttttta tcccatgttt 14760
catctatcat agatttaaac gcagtaatgc tcgcaacatt aacatcttga accgttggta 14820
caattccgtt ccataaattt ataatgttcg ccatttatat aactcatttt ttgaatatac 14880
ttttaattaa caaaagagtt aagttactca tatggacgcc gtccagtctg aacatcaatc 14940
tttttagcca gagatatcat agccgctctt agagtttcag cgtgattttc caacctaaat 15000
agaacttcat cgttgcgttt acaacacttt tctatttgtt caaactttgt tgttacatta 15060
gtaatctttt tttccaaatt agttagccgt tgtttgagag tttcctcatt gtcgtcttca 15120
tcggctttaa caattgcttc gcgtttagcc tctggctttt tagcagccgt tgtagaaaaa 15180
aattcagttg ctggaattgc aagatcgtca tctccgggga aaagagttcc gtccatttaa 15240
agtacagatt ttagaaactg acactctgcg ttatttatat ttggtacaac acatggatta 15300
taaatattga tgttaataac atcagaaaat gtaaagtcta tacattgttg catcgtgtta 15360
aattttctaa tggatctagt attattgggt ccaacttctg cctgaaatcc aaatatggaa 15420
gcggatacaa aaccgtttcc tggataaacc acacatctcc acttttgctt tacatcagaa 15480
attgtgtcgt tgacatcttg aactctccta tctaatgccg gtgttccacc tatagatttt 15540
gaatattcga atgctgcatg agtagcatta aattccttaa tattgccata attttcatat 15600
attgagtaac cctggataaa aagtaaacac accgcagccg tagctaccac aataaaaaaa 15660
attgatagag agttcattta taatctatta gaagctgaca aaattttttt acacgcatca 15720
gacaatgctt taataaatag ttcaacatct acttttgtca tatcgaaccg atggtatgat 15780
tctaacctag aattacatcc gaaaaagttg actatgttca tagtcattaa gtcattaaca 15840
aacaacattc cagactctgg attataagac gatactgttt cgtcacaatt acctacctta 15900
atcatgtgat tatgaatatt ggctattaga gcaccttcta agaaatctat aatatctttg 15960
aaacacgatt taaaatcaaa ccacgaatat acttctacga agaaagttag tttacccata 16020
ggagaaataa ctataaatgg agatctaaat acaaaatccg gatctatgat agttttaaca 16080
ttattatatt ctctattaaa tacctccaca tctaaaaatg ttaattttga aactatgtct 16140
tcgtttatta ccgtacctga actaaacgct ataagctcta ttgtttgaga actctttaaa 16200
cgatattctt gaaatacatg taacaaagtt tcctttaact cggtcggttt atctaccata 16260
gttacagaat ttgtatcctt atctataata taataatcaa aatcgtataa agttatataa 16320
ttatcgcgtt cagattggga tcttttcaaa tagactaaaa accccatttc tctagtaagt 16380
atcttatgta tatgtttgta aaatatcttc atggtgggaa tatgctctac cgcagttagc 16440
cattcctcat tgacagcggt agatgtatta gacaaaacta ttccaatgtt taacaagggc 16500
cattttacga gattattaaa tccttgtttg ataaatgtag ccaatgaggg ttcgagttca 16560
acgacgattg aattctcttc ccgcggatgc tgcatgatga acgacgggat gttgttcgat 16620
tgatttggaa ttctttttcg actttttgtt tatattaaat attttaaaat ttatagcgga 16680
tagcaattca tgtaccacgg ataatgtaga cgcgtattgc gcatcgatat ctttattatt 16740
agataaattt atcaataaat gtgagaagtt tgcctcgtta aggtcttcca tttaaatatt 16800
atataaacat ttgtgtttgt atcttattcg tcttttatgg aatagttttt tactagtaaa 16860
gctgcaatta cacactttgt ccgtaaaaca taaatataaa caccagcttt tatcaatcgt 16920
tccaaaaagt cgacggcgga catttttaac atggcatcta ttttaaatac acttaggttt 16980
ttggaaaaaa catcatttta taattgtaac gattcaataa ctaaagaaaa gattaagatt 17040
aaacataagg gaatgtcatt tgtattttat aagccaaagc attctaccgt tgttaaatac 17100
ttgtctggag gaggtatata tcatgatgat ttggttgtat tggggaaggt aacaattaat 17160
gatctaaaga tgatgctatt ttacatggat ttatcatatc atggagtgac aagtagtgga 17220
acaatttaca aattgggatc gtctatcgat agactttctc taaataggac tattgttaca 17280
aaagttaata attataatta tgatacattt tttgacgatg atgattgatc gctattgcac 17340
aattttgttt ttttactttc taatatagcg tttagattct ttttcatgtg cgaatattga 17400
tttactaaaa tatctatgtt taacttttgt tctataacgt ccttatcggc ggtatcggta 17460
catatacgta attcaccttc acaaaatacg gagtcttcga taataatagc caatcgatta 17520
ttggatctag ctgtctgtat catattcaac atgtttaata tatcctttcg tttccccttt 17580
acaggcatcg atcgtagcat attttccgcg tctgagatgg aaatgttaaa actacaaaaa 17640
tgcgtaatgt tagcccgtcc taatattggt acgtgtctat aagtttggca tagtagaata 17700
atagacgtgt ttaaatgcct tccaaagttt aagaattcta ttagagtatt gcattttgat 17760
agtttatcgc ctacatcatc aaaaataagt aaaaagtgtg ctgatttttt atgattttgt 17820
gcgacagcaa tacatttttc tatgttactt ttagttcgta tcagattata ttctagagat 17880
tcctgactac taacgaaatt aatatgattt ggccaaatgt atccatcata atctggatta 17940
taaacgggtg taaacaagaa tacatgttta tattttttaa ctagtgtaga aaacagagat 18000
agtaaataga tagtttttcc agatccagat cctcccgtta aaaccattct aaacggcatt 18060
tttaataaat tttctcttga aaattgtttt tcttggaaac aattcataat tatatttaca 18120
gttactaaat taatttgata ataaatcaaa atatggaaaa ctaaggtcgt tagtagggag 18180
gagaacaaag aaggcacatc gtgacataaa taacatttat tatcatgatg acaccagaaa 18240
acgacgaaga gcagacatct gtgttctccg ctactgttta cagagacaaa attcagggaa 18300
agaataaacg caaacgcgtg attggtctat gtattagaat atctatggtt atttcactac 18360
tatctatgat taccatgtcc gcgtttctca tagtgcgcct aaatcaatgc atgtctgcta 18420
acgaggctgc tattactgac gccgctgttg ccgttgctgc tgcatcatct actcatagaa 18480
aggttgcgtc tagcactacg caatatgatc acaaagaaag ctgtaatggt ttatattacc 18540
agggttcttg ttatatatta cattcagact accagttatt ctcggatgct aaagcaaatt 18600
gcactgcgga atcatcaaca ctacccaata aatccgatgt cttgactacc tggctcattg 18660
attatgttaa ggatacatgg ggatctgatg gtaatccaat tacaaaaact acatccgatt 18720
atcaagattc tgatgtatca caagaagtta gaaagtattt ttgtgttaaa acaatgaact 18780
aatatttatt tttgtacatt aataaatgaa atcgcttaat agacaaactg taagtaggtt 18840
taagaagttg tcggtgccgg tcgctataat gatgatactc tcaaccatta ttagtggcat 18900
aggaacattt ctgcattaca aagaagaact gatgcctagt gcttgcgcca atggatggat 18960
acaatacgat aaacattgtt atttagatac taacattaaa atgtctacag ataatgcggt 19020
ttatcagtgt cgtaaattac gagccagatt gcctagaccg gatactagac atctgagagt 19080
attgtttagt attttttata aagattattg ggtaagttta aaaaagacca atgataaatg 19140
gttagatatt aataatgata aagatataga tattagtaaa ttaacaaatt ttaaacaact 19200
aaacagtacg acggatgctg aagcgtgtta tatatacaag tctggaaaac tggttaaaac 19260
agtatgtaaa agtactcaat ctgtactatg tgttaaaaaa ttctacaagt gacaacaaaa 19320
aatgaattaa taataagtcg ttaacgtacg ccgccatgga cgccgcgttt gttattactc 19380
caatgggtgt gttgactata acagatacat tgtatgatga tctcgatatc tcaatcatgg 19440
actttatagg accatacatt ataggtaaca taaaaactgt ccaaatagat gtacgggata 19500
taaaatattc cgacatgcaa aaatgctact ttagctataa gggtaaaata gttcctcagg 19560
attctaatga tttggctaga ttcaacattt atagcatttg tgccgcatac agatcaaaaa 19620
ataccatcat catagcatgc gactatgata tcatgttaga tatagaagat aaacatcagc 19680
cattttatct attcccatct attgatgttt ttaacgctac aatcatagaa gcgtataacc 19740
tgtatacagc tggagattat catctaatca tcaatccttc agataatctg aaaatgaaat 19800
tgtcgtttaa ttcttcattc tgcatatcag acggcaatgg atggatcata attgatggga 19860
aatgcaatag taatttttta tcataaaagt tgtaaagtaa ataataaaac aataaatatt 19920
gaactagtag tacgtatatt gagcaatcag aaatgatgct ggtacctctt atcacggtga 19980
ccgtagttgc gggaacaata ttagtatgtt atatattata tatttgtagg aaaaagatac 20040
gtactgtcta taatgacaat aaaattatca tgacaaaatt aaaaaagata aagagttcta 20100
attccagcaa atctagtaaa tcaactgata gcgaatcaga ctgggaggat cactgtagtg 20160
ctatggaaca aaacaatgac gtagataata tttctaggaa tgagatattg gacgatgata 20220
gcttcgctgg tagtttaata tgggataacg aatccaatgt tatggcgcct agcacagaac 20280
acatttacga tagtgttgct ggaagcacgc tgctaataaa taatgatcgt aatgaacaga 20340
ctatttatca gaacactaca gtagtactta atgaagatac caaacagaat cctaactatt 20400
catccaatcc tttcgtaaat tataataaaa ccagtatttg tagcaagtca aatccgttca 20460
ttacagaact caacaataaa tttagtgaga ataatccgtt tagacgagca catagcgatg 20520
attatcttaa taagcaagaa caagatcatg aacacgatga tatagaatca ttggtgtgat 20580
tagtttcctt tttataaaat tgaagtaata tttagtatta ttgctgccgt cacgttgtac 20640
aaatggagat attccctgta ttcggcattt ctaaaattag caattttatt gctaataatg 20700
actgtagata ttatatagat acagaacatc aaaaaattat atctgatgag atcaatagac 20760
agatggatga aacggtactt cttaccaaca tcttaagcgt agaagttgta aatgacaatg 20820
agatgtacca tcttattcct catagattat cgacgattat actctgtatt agttctgtcg 20880
gaggatgtgt tatctctata gataatgacg tcaatggcaa aaatattcta acctttccca 20940
ttgatcatgc tgtaatcata tccccactga gtaaatgtgt cgtagttagc aagggtccta 21000
caaccatatt ggttgttaaa gcggatatac ctagcaaacg attggtaaca tcgtttacaa 21060
acgacatact gtatgtaaac aatctatcac tgattaatta ttcgccgttg tctgtattca 21120
ttattagacg agttaccgac tatttggata gacacatatg cgatcagata tttgcgaata 21180
ataagtggta ttccattata accatcgaca ataagcagtt tcctattcca tcaaactgta 21240
taggtatgtc ctctgccaag tacataaatt ctagcatcga gcaagatact ttaatacatg 21300
tttgtaacct cgagcatcca ttcgacttag tatacaaaaa aatgcagtcg tacaattctg 21360
tacctatcaa ggaacaaata ttgtacggta gaattgataa tataaatatg agcattagta 21420
tttctgtgga ttaatagatt tctagtatgg ggatcattaa tcatctctaa tctctaaata 21480
cctcataaaa cgaaaaaaaa gctattatca aatactgtac ggaatggatt cattctcttc 21540
tctttttatg aaactctgtt gtatatctac tgataaaact ggaagcaaaa aatctgataa 21600
aaagaataag aataagatca aggattatta taaaataaca atagttcctg gttcctcttc 21660
cacgtctact agctcgtggt attatacaca tgcctagtaa tagtctcttt gcgttgacgg 21720
aaagcagact agaaataaca ggctaaaatg ttcagacacc ataatagttc ccaacccaga 21780
taataacaga gtaccatcaa cacattcctt taaactcaat cccaaaccca aaaccgttaa 21840
aatgtatccg gccaattgat agtagataat gaggtgtaca gcgcatgatg atttacacag 21900
taaccaaaat gaaaatactt tagtaattat aagaaatata gatggtaacg tcatcatcaa 21960
caatccaata atatgccgga gagtaaacat tgacggataa aacaaaaatg ctccgcataa 22020
ctctatcatg gcaataacac aaccaaatac ttgtaagatt cctaaattag tagaaaatac 22080
aacggatatc gatgtataag tgatctcgag aaataataag aataaagtaa tgcccgtaaa 22140
gataaacatc aacattgttt ggtaatcatt aaaccaatta gtatgaagtt gaactaattt 22200
cacagtagat tttattccag tattatcccc gcatgtataa gtacctggta agatatcttt 22260
atattccata atcaatgaga catcactatc tgataacgaa tgaagtctag cactagtatg 22320
ccatttactt aatattgtcg tcttggaagt tttattataa gttaaaatat catggttatc 22380
caatttccat ctaatatact ttgtcggatt atctatagta cacggaataa tgatggtatc 22440
attacatgct gtatactcta tggtctttgt agttgttata acaaccaacg tatagaggta 22500
tatcaacgat attctaactc ttgacatttt ttatttattt aaaatgatac ctttgttatt 22560
tattttattc tattttgcta acggtattga atggcataag tttgaaacga gtgaagaaat 22620
aatttctact tacttattag acgacgtatt atacacgggt gttaatgggg cggtatacac 22680
attttcaaat aataaactaa acaaaactgg tttaactaat aataattata taacaacatc 22740
tataaaagta gaggatgcgg aaccaataac ggaaatccca aatgttggaa aatagacggt 22800
tcagacgacc caaaacatag aggtagagga tacgctcctt atcaaaatag caaagtaacg 22860
ataatcagtc acaacggatg tgtactatct gacataaaca tatcaaaaga aggaattaaa 22920
cgatggagaa gatttgacgg accatgtggt tatgatttat acacggcgga taacgtaatt 22980
ccaaaagatg gtttacgagg agcattcgtc gataaagatg gtacttatga caaagtttac 23040
attcttttca ctgatactat cggctcaaag agaattgtca aaattccgta tatagcacaa 23100
atgtgcctaa acgacgaagg tggtccatca tcattgtcta gtcatagatg gtcgacgttt 23160
ctcaaagtcg aattagaatg tgatatcgac ggaagaagtt atagacaaat tattcattct 23220
agaactataa aaacagataa tgatacgata ctatatgtat tcttcgatag tccttattcc 23280
aagtccgcat tatgtaccta ttctatgaat accattaaac aatctttttc tacgtcaaaa 23340
ttggaaggat atacaaagca attgccgtct ccagctcctg gtatatgttt accagctgga 23400
aaagttgttc cacataccac gtttgaagtc atagaaaaat ataatgtact agatgatatt 23460
ataaagcctt tatctaacca acctatcttc gaaggaccgt ctggtgttaa atggttcgat 23520
ataaaggaga aggaaaatga acatcgggaa tatagaatat acttcataaa agaaaattct 23580
atatattcgt tcgatacaaa atctaaacaa actcgtagct cgcaagtcga tgcgcgacta 23640
ttttcagtaa tggtaacttc gaaaccgtta tttatagcag atatagggat aggagtagga 23700
atgccacaaa tgaaaaaaat acttaaaatg taatcttaat cgagtacacc gcacgacaat 23760
gaacaaacat aagacagatt atgctggtta tgcttgctgc gtaatatgcg gtctaattgt 23820
tggaattatt tttacagcga cactattaaa agttgtagaa cgtaaattag ttcatacacc 23880
atcaatagat aaaacgataa aagatgcata tattagagaa gattgtccta ctgactggat 23940
aagctataat aataaatgta tccatttatc tactgatcga aaaacctggg aggaaggacg 24000
taatgcatgc aaagctctaa atccaaattc ggatctaatt aagatagaga ctccaaacga 24060
gttaagtttt ttaagaagca ttagacgcgg atattgggta ggagaatccg aaatattaaa 24120
ccagacaacc ccatataatt ttatagctaa aaatgccacg aagaatggaa ctaaaaaacg 24180
gaaatatatt tgtagtacaa cgaatactcc caaactacat ttttatcata ccactacttc 24240
ggttagatgt tttagaaaaa aataaatatc gccgtaccgt tcttgttttt ataaaaataa 24300
caattaacaa ttatcaaatt ttttctttaa tattttacgt ggttgaccat tcttggtggt 24360
aaaataatct cttagtgttg gaatggaatg ctgtttaatg tttccgcact catcgtatat 24420
tttgacgtat gcagtcacat cgtttacgca atagtcagac tgtagttcta tcatgcttcc 24480
tacatcagaa ggaggaacag ttttaaagtc tcttggtttt aatctattgc cattagtttt 24540
catgaaatcc tttgttttat ccacttcaca ttttaaataa atgtccacta tacattcttc 24600
tgttaatttt actagatcgt catgggtcat agaatttata ggttccgtag tccatggatc 24660
caaactagca aacttcgcgt atacggtatc gcgattagtg tatacaccaa ctgtatgaaa 24720
attaagaaaa cagtttaata aatcaacaga aatatttaat cctccgtttg atacagatgc 24780
gccatattta tggatttcgg attcacacgt tgtttgtctg aggtgttcgt ctagtgttgc 24840
ttctacgtaa acttcgattc ccatatattc tttattgtca gaatcgcata ccgatttatc 24900
atcatacact gtttgaaaac taaatggtat acacatcaaa ataataaata ataacgagta 24960
cattctgcaa tattgttatc gtaattggaa aaatagtgtt cgagtgagtt ggattatgtg 25020
agtattggat tgtatatttt attttatatt ttatattttg tagtaagaat agaatgctaa 25080
tgtcaagttt attccaatag atgtcttatt aaaaaacata tataataaat aacaatggct 25140
gaatggcata aaattatcga ggatatctca aaaaataata agttcgagga tgccgccatc 25200
gttgattaca agactacaaa gaatgttcta gctgctattc ctaacagaac atttgccaag 25260
attaatcctc tcatcactaa tcgtaatatt ctaaaacctc ttattggtca gaaatattgt 25320
attgtatata ctaactctct aatggatgag aacacgtatg ctatggagtt gcttactggg 25380
tacgcccctg tatctccgat cgttatagcg agaactcata ccgcacttat atttttgatg 25440
ggtaagccaa caacatccag acgtgacgtg tatagaacgt gtagagatca cgctacccgt 25500
gtacgtgcaa ctggtaatta aaataaaaag taatattcat atgtagtgtc aattttaaat 25560
gatgatgatg aaatggataa tatccatatt gacgatgtca ataatgccgg tattggcata 25620
cagttcatcg atttttagat ttcattcaga ggatgtggaa ttatgttatg ggcatttgta 25680
ttttgatagg atctataatg tagtaaatat aaaatataat ccgcatattc catatagata 25740
taattttatt aatcgcacgt taaccgtaga tgaactagac gataatgtct tttttacaca 25800
tggttatttt ttaaaacaca aatatggttc acttaatcct agtttgattg tctcattatc 25860
aggaaactta aaatataatg atatacaatg ctcagtaaat gtatcgtgtc tcattaaaaa 25920
tttggcaacg agtacatcta ctatattaac atctaaacat aagacttatt ctctacatcg 25980
gtccacgtgt attactataa taggatacga ttctattata tggtataaag atataaatga 26040
catctatgat tttactgcaa tatgtatgct aatagcgtct acattgatag tgaccatata 26100
cgtgtttaaa aaaataaaaa tgaactctta attatgctat gctattagaa atggataaaa 26160
tcaaaattac ggttgattca aaaattggta atgttgttac catatcgtat aacttggaaa 26220
agataactat tgatgtcaca cctaaaaaga aaaaagaaaa ggatgtatta ttagcgcaat 26280
cagttgctgt cgaagaggca aaagatgtca aggtagaaga aaaaaatatt atcgatattg 26340
aagatgacga tgatatggat gtagaaagcg cataatacga tctataaaaa taagtatata 26400
aatacttttt atttactgta ctcttactgt gtagtggtga taccctactc gattattttt 26460
ttaaaaaaaa atacttattc tgattcttct agccatttcc gtgttcgttc gaatgccaca 26520
tcgacgttaa agatagggga gtagttgaaa tctagttctg cattgttggt acgcacctca 26580
aatgtagtgt tggatatctt caacgtatag ttgttgagta gtgatggttt tctaaataga 26640
attctcttca tatcattctt gcacgcgtac atttttagca tccatcttgg aatcctagat 26700
ccttgttcta ttcccaatgg tttcatcaat agaagattaa acatatcgta cgaacacgat 26760
ggagagtaat cgtagcaaaa gtaagcattt cctttaatct cagatcccgg atactggata 26820
tattttgcag ccaacacgtg catccatgca gcatttccta catatacccg gctatgtacc 26880
gcgttatcat cgactgtacg atacataatg ttaccgtgtt gcttacattg ctcgtaaaag 26940
actttcatca atttgtctcc ttctccgtaa attccagtgg gtcttaggca acaagtatac 27000
aattttgctc cattcatgat tacggaatta ttggctttca taaccagttg ctcggccata 27060
cgtttacttt ttgcgtatac atgtcctggt gatatatcat aaagggtatg ctcatggccg 27120
atgaatggat caccgtgttt attgggtcct attgcttcca tgctactagt atagatcaaa 27180
tacttgattc ctaggtccac acaagctgcc aatatagtct gtgttccata atagtttact 27240
ttcatgattt cattatcggt gtattttcca aatacatcca ctagagcagc tgtatgaata 27300
atcagattta ccccatctag cgcttctctt accttatcaa agtcgtttat atcacattgt 27360
atatagttta taaccttaac tttcgaggtt attggttgtg gatcttctac aatatctatg 27420
actctgattt cttgaacatc atctgcacta attaacagtt ttactatata cctgcctaga 27480
aatccggcac caccagtaac cgcgtacacg gccattgctg ccactcataa tatcagacta 27540
cttattctat tttactaaat aatggctgtt tgtataatag accacgataa tatcagagga 27600
gttatttact ttgaaccagt ccatggaaaa gataaagtta ttggattaaa atccggaacg 27660
tatagtttga taattcatcg ttacggagat attagtcaag gatgtgattc cataggcagt 27720
ccagaaatat ttatcggtaa catctttgta aacagatatg gtgtagcata tgtttattta 27780
gatacagatg taaatatatc tacaattatt ggaaaggcgt tatctatttc aaaaaatgat 27840
cagagattag cgtgtggagt tattggtatt tcttacataa atgaaaagat aatacatttt 27900
cttacaatta acgagaatgg cgtttgatat atcagttaat gcgtctaaaa caataaatgc 27960
attagtttac ttttctactc agcaaaataa attagtcata cgtaatgaag ttaatgatac 28020
acactacact gtcgaatttg atagggacaa agtagttgac acgtttattt catataatag 28080
acataatgac tccatagaga taagaggggt gcttccagag gaaactaata ttggttgcgc 28140
ggttaatacg ccggttagta tgacttactt gtataataag tatagtttta aactgatttt 28200
agcagaatat ataagacaca gaaatactat atccggcaat atttattcgg cattgatgac 28260
actagatgat ttggctatta aacagtatgg agacattgat ctattattta atgagaaact 28320
taaagtagac tccgattcgg gactatttga ctttgtcaac tttgtaaagg atatgatatg 28380
ttgtgattct agaatagtag tagctctatc tagtctagta tctaaacatt gggaattgac 28440
aaataaaaaa tataggtgta tggcattagc cgaacatata tctgatagta ttccaatatc 28500
tgagctatct agactacgat acaatctatg taagtatcta cgcgggcaca ctgagagcat 28560
agaggatgaa tttgattatt ttgaagacga tgattcgtct acatgttctg ccgtaaccga 28620
cagggaaacg gatgtataat tttttttata gcgtgaagga tatgataaaa aatataattg 28680
ttgtatttat cccattccaa tcaccttata tgattctgta acacaatgaa ggagtcttat 28740
agatgtatag aggtcagata ctggtttgat aaactgttta ttccacataa gtatgtttga 28800
ctttatggtt agacccgcat actttaacaa atcactgaaa attggagtta ggtattgacc 28860
tctcagaatc agttgccgtt ctggaacatt aaatgtattt tttatgatat actccaacgc 28920
atttatgtgg gcatacaaca agtcattact aatggagtat tccaagagaa gagatttcaa 28980
cagactgttt atgaactcga atgccgcctc attgtcgctt atattgatga tgtcgaattc 29040
tcccaatatc atcaccgatg agtagctcat cttgttatcg ggatccaagt tttctaaaga 29100
tgtcattaaa ccctcgatca tgaatggatt tatcatcatc gtttttatgt tggacatgag 29160
cttagtccgt ttgtccacat ctatagacga cgatttctga attatttcat atatccctct 29220
ctttaactcc aggaacttgt caggatggtc tactttaata tgttctcgtc taagagatga 29280
aaatctttgg atggttgcac gcgacttttc tctaaaggat cctctcttaa atgaatccat 29340
cttatccttg gacaagatgg acagtctatt ttccttagat ggtttaatat ttttgttacc 29400
catgatctat aaaggtagac ctaatcgtct cggatgacca tatatttatt ttcagtttta 29460
ttatacgcat aaattgtaaa aaatatgtta ggtttacaaa aatgtctcgt ggggcattaa 29520
tcgtttttga aggattggac aaatctggaa aaacaacaca atgtatgaac atcatggaat 29580
ctataccggc aaacacgata aaatatctta actttcctca gagatccact gtcactggaa 29640
agatgataga tgactatcta actcgtaaaa aaacctataa tgatcatata gttaatctat 29700
tattttgtgc aaatagatgg gagtttgcat cttttataca agaacaacta gaacagggaa 29760
ttactttaat agttgataga tacgcattct ctggagtagc gtatgccgcc gctaaaggcg 29820
cgtcaatgac tctcagtaag agttatgaat ctggattgcc taaacccgac ttagttatat 29880
tcttggaatc tggtagcaaa gaaattaata gaaacgtcgg cgaggaaatt tatgaagatg 29940
ttacattcca acaaaaggta ttacaagaat ataaaaaaat gattgaagaa ggagatattc 30000
attggcaaat tatttcttct gaattcgagg aagatgtaaa gaaggagttg attaagaata 30060
tagttataga ggctatacac acggttactg gaccagtggg gcaactgtgg atgtaatagt 30120
gaaattacat tttttataaa tggatgaagc atattactct ggcaacttgg aatcagtact 30180
cggatacgtg tccgatatgc ataccgaact cgcatcaata tctcaattag ttattgccaa 30240
gatagaaact atagataatg atatattaaa caaggacatt gtaaatttta tcatgtgtag 30300
atcaaacttg gataatccat ttatctcttt cctagatact gtatatacta ttatagatca 30360
agagatctat cagaccgaat tgattaattc attagacgac aatgaaatta tcgattgtat 30420
agttaacaag tttatgagct tttataagga taacctagaa aatatagtag atgctatcat 30480
tactctaaaa tatataatga ataatccaga ttttaaaact acgtatgccg aagtactcgg 30540
ttccagaata gcggatatag atattaaaca agtgatacgt gagaatatac tacaattgtc 30600
taataatatc cgcgaacgat atttgtgaaa atattaaaaa aaaatacttt ttttattaaa 30660
tgacgtcgct tcgcgaattt agaaaattat gctgtgatat atatcacgca tcaggatata 30720
aagaaaaatc taaattaatt agagacttta taacagatag ggatgataaa tatttgatca 30780
ttaagctatt gcttcccgga ttagacgata gaatttataa catgaacgat aaacaaatta 30840
taaaattata tagtataata tttaaacaat ctcaggaaga tatgctacaa gatttaggat 30900
acggatatat aggagacact attaggactt tcttcaaaga gaacacagaa atccgtccac 30960
gagataaaag cattttaact ttagaagaag tggatagttt tttaactacg ttatcatccg 31020
taactaaaga atcgcatcaa ataaaattat tgactgatat cgcatccgtt tgtacatgta 31080
atgatttaaa atgtgtagtc atgcttattg ataaagatct aaaaattaaa gcgggccctc 31140
ggtacgtact taacgctatt agtcctcatg cctatgatgt gtttagaaaa tctaataact 31200
tgaaagagat aatagaaaat gcatctaaac aaaatctaga ctctatatct atttctgtta 31260
tgactccaat taatcccatg ttagcggaat cgtgtgattc tgtcaataag gcgtttaaaa 31320
aatttccatc aggaatgttt gcggaagtca aatacgatgg tgaaagagta caagttcata 31380
aaaataataa cgagtttgcc ttctttagta gaaacatgaa accagtactc tctcataaag 31440
tggattatct caaagaatac ataccgaaag catttaaaaa agctacgtct atcgtattgg 31500
attctgaaat tgttcttgta gacgaacata atgtaccgct cccgtttgga agtttaggta 31560
tacacaaaaa gaaagaatat aaaaactcta acatgtgttt gttcgtgttt gactgtttgt 31620
actttgatgg attcgatatg acggacattc cattgtacga acgaagatct tttctcaaag 31680
atgttatggt tgaaataccc aatagaatag tattctcaga gttgacgaat attagtaacg 31740
agtctcagtt aactgacgta ttggatgatg cactaacgag aaaattagaa ggattggtct 31800
taaaagatat taatggagta tacgaaccgg gaaagagaag atggttaaaa ataaagcgag 31860
actatttgaa cgagggttcc atggcagatt ctgccgattt agtagtacta ggtgcttact 31920
atggtaaagg agcaaagggt ggtatcatgg cagtctttct aatgggttgt tacgacgatg 31980
aatccggtaa atggaagacg gttaccaagt gttcaggaca cgatgataat acgttaaggg 32040
agttgcaaga ccaattaaag atgattaaaa ttaacaagga tcccaaaaaa attccagagt 32100
ggttagtagt taataaaatc tatattcccg attttgtagt agaggatcca aaacaatctc 32160
agatatggga aatttcagga gcagagttta catcttccaa gtcccatacc gcaaatggaa 32220
tatccattag atttcctaga tttactagga taagagagga taaaacgtgg aaagaatcta 32280
ctcatctaaa cgatttagta aacttgacta aatcttaata gttacataca aattaaaata 32340
acactattta gttggtggtc gccatggatg gtgttattgt atactgtcta aacgcgttag 32400
taaaacatgg cgaggaaata aatcatataa aaaatgattt catgattaaa ccatgttgtg 32460
aaaaagtcaa gaacgttcac attggcggac aatctaaaaa caatacagtg attgcagatt 32520
tgccatatat ggataatgcg gtatccgatg tatgcaattc actgtataaa aagaatgtat 32580
caagaatatc cagatttgct aatttgataa agatagatga cgatgacaag actcctactg 32640
gtgtatataa ttattttaaa cctaaagatg ccattcctgt tattatatcc ataggaaagg 32700
atagagatgt ttgtgaacta ttaatctcat ctgataaagc gtgtgcgtgt atagagttaa 32760
attcatataa agtagccatt cttcccatgg atgtttcctt ttttaccaaa ggaaatgcat 32820
cattgattat tctcctgttt gatttctcta tcgatgcggc acctctctta agaagtgtaa 32880
ccgataataa tgttattata tctagacacc agcgtctaca tgacgagctt ccgagttcca 32940
attggttcaa gttttacata agtataaagt ccgactattg ttctatatta tatatggttg 33000
ttgatggatc tgtgatgcat gcaatagctg ataatagaac ttacgcaaat attagcaaaa 33060
atatattaga caatactaca attaacgatg agtgtagatg ctgttatttt gaaccacaga 33120
ttaggattct tgatagagat gagatgctca atggatcatc gtgtgatatg aacagacatt 33180
gtattatgat gaatttacct gatgtaggcg aatttggatc tagtatgttg gggaaatatg 33240
aacctgacat gattaagatt gctctttcgg tggctggtat ttggaaagtt ttataggtag 33300
ttgatagaac aaaatacata attttgtaaa aataaatcac tttttatact aatatgacac 33360
gattaccaat acttttgtta ctaatatcat tagtatacgc tacacctttt cctcagacat 33420
ctaaaaaaat aggtgatgat gcaactttat catgtaatcg aaataataca aatgactacg 33480
ttgttatgag tgcttggtat aaggagccca attccattat tcttttagct gctaaaagcg 33540
acgtcttgta ttttgataat tataccaagg ataaaatatc ttacgactct ccatacgatg 33600
atctagttac aactatcaca attaaatcat tgactgctag agatgccggt acttatgtat 33660
gtgcattctt tatgacatcg cctacaaatg acactgataa agtagattat gaagaatact 33720
ccacagagtt gattgtaaat acagatagtg aatcgactat agacataata ctatctggat 33780
ctacacattc accggaaact agttctgaga aacctgatta tatagataat tctaattgct 33840
cgtcggtatt cgaaatcgcg actccggaac caattactga taatgtagaa gatcatacag 33900
acaccgtcac atacactagt gatagcatta atacagtaag tgcatcatct ggagaatcca 33960
caacagacga gactccggaa ccaattactg ataaagaaga agatcataca gttacagaca 34020
ctgtctcata cactacagta agtacatcat ctggaattgt cactactaaa tcaaccaccg 34080
atgatgcgga tctttatgat acgtacaatg ataatgatac agtaccatca actactgtag 34140
gcggtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa atatttggta 34200
ttaccgcatt aattatattg tcggccgtgg caatattctg tattacatat tatatatata 34260
ataaacgttc acgtaaatac aaaacagaga acaaagtcta gatttttgac ttacataaat 34320
gtctgggata gtaaaatcta tcatattgag cgggccatct ggtttaggaa agacagccat 34380
agccaaaaga ctatgggaat atatttggat ttgtggtgtc ccataccact agatttcctc 34440
gtcctatgga acgagaaggt gtcgattacc attacgttaa cagagaggcc atctggaagg 34500
gaatagccgc cggaacatac tgagttttta ggaaatattt acggaacttc taaaactgct 34560
gtgaatacag cggctattaa taatcgtatt tgtgtgatgg atctaaacat cgacggtgtt 34620
agaagtttta aaaatactta cctaatgcct tactcggtgt atataagacc tacctctctt 34680
aaaatggttg agaccaagct tcgttgtaga aacactgaag cggatgatga gattcatcgt 34740
cgtgtgatgt tggcaaaaac tgacatggat gaggcaggtg aagccggtct attcgacact 34800
attatcattg aagatgatgt gaatttagca tatagtaagt taattcagat actacaggac 34860
cgtattagaa tgtattttaa cactaattag agacttaaga cttaaaactt gataattaat 34920
aatataactc gtttttatat gtggctattt caacgtctaa tgtattagtt aaatattaaa 34980
acttaccacg taaaacttaa aatttaaaat gatatttcat tgacagatag atcacacatt 35040
atgaactttc aaggacttgt gttaactgac aattgcaaaa atcaatgggt cgttggacca 35100
ttaataggaa aaggtggatt tggtagtatt tatactacta atgacaataa ttatgtagta 35160
aaaatagagc ccaaagctaa cggatcatta tttaccgaac aggcatttta tactagagta 35220
cttaaaccat ccgttatcga agaatggaaa aaatctcaca atataaagca cgtaggtctt 35280
atcacgtgca aggcatttgg tctatacaaa tccattaatg tggaatatcg attcttggta 35340
attaatagat taggtgcaga tctagatgcg gtgatcagag ccaataataa tagattacca 35400
aaaaggtcgg tgatgttgat cggaatcgaa atcttaaata ccatacaatt tatgcacgag 35460
caaggatatt ctcacggaga tattaaagcg agtaatatag tcttggatca aatagataag 35520
aataaattat atctagtgga ttacggattg gtttctaaat tcatgtctaa tggcgaacat 35580
gttccattta taagaaatcc aaataaaatg gataacggta ctctagaatt tacacctata 35640
gattcgcata aaggatacgt tgtatctaga cgtggagatc tagaaacact tggatattgt 35700
atgattagat ggttgggagg tatcttgcca tggactaaga tatctgaaac aaagaattgt 35760
gcattagtaa gtgccacaaa acagaaatat gttaacaata ctgcgacttt gttaatgacc 35820
agtttgcaat atgcacctag agaattgctg caatatatta ccatggtaaa ctctttgaca 35880
tattttgagg aacccaatta cgacaagttt cggcacatat taatgcaggg tgtatattat 35940
taagtgtggt gtttggttga tgtaaaattt ttgtcgataa aaattaaaaa ataacttaat 36000
ttattattga tctcgtgtgt acaaccgaaa tcatggcgat gttttacgca cacgctctcg 36060
gtgggtacga cgagaatctt catgcctttc ctggaatatc atcgactgtt gccaatgatg 36120
tcagtttata ataacaagta tgacattgta aaagacaaat atatgtggtg ttacagtcag 36180
gtgaacaaga gatatattgg agcactgctg cctatgtttg agtgcaatga atatctacaa 36240
attggagatc cgatccatga tcaagaagga aatcacatat cgccacaaaa actactatgc 36300
tctaagcgga atcgggtacg agagtctaga cttgtgtttg gaaggagtag ggattcatca 36360
tcacgtactt gaaacagaaa acgctgtata tggaaaagtt caacatgatt attctactat 36420
caaagagaag gccaaagaaa tgaatgcact cagttcagga cctatcatcg attaccacgt 36480
ctggatagga gattgtatct gtcaagttac tgctgtggac gtacatggaa aggaaattat 36540
gagaatgaga ttcaaaaagg gtgcggtgct tccgatccca aatctggtaa aagttaaact 36600
tggggagaat gatacagaaa atctttcttc tactatatcg gcggcaccat cgaggtaacc 36660
acctctctgg aagacagtgt gaatcatgta ctcatgaaac gtttggaatc tatacgccat 36720
atgtggtctg ttgtatatga tcattttgat attgtgaatg gtaaagaatg ctgttatgtg 36780
catacgcatt tgtctaatca aaatcttata ccgagtactg taaaaacaaa tttgtacatg 36840
aagactatgg gatcatgcat tcaaatgagt atcttagcga actgaaggaa tcaggtggat 36900
ggagtcccag accagaaatg caggaatttg aatatccaga tggagtggaa gacactgaat 36960
caattgagag attggtagag gagttcttca atagatcaga acttcaggct ggtaaatcta 37020
ttaatgttaa acatacatct gtttcagcta agcaactaag aacacgtata ctctcatctt 37080
ttgccaacac agagggtgga tatttgttca ttggagttga taataataca cacaaagtat 37140
ttggattcac ggtgggttac gactacctca gactgataga gaatgatata gaaaagcata 37200
tcaaaagact ttgtgttgtg tatttctgtg agaagaaaga ggacatcaag tacacgtgtc 37260
gattcatcaa ggtatataaa cctggggatg aggctacctc gacatacgtg tgcgctatca 37320
aagtggaaag atgctgttgt gctgtgtttg cagattggcc agaatcatgg tatcaagaag 37380
tattctccag atgaataggt gtcacatata aaattttaat taatgtaact atagagaaca 37440
aataataggt tgtaatatca tatagacaat aactaacaat taattagtaa ctgttatctc 37500
tttttaacta actaactata cctattaata catcgtaatt atagttctta acatctatta 37560
atcattgatt cgcttcttta attttttata aaccaacatt gttaattgaa aagggataac 37620
atgttacaga atataaatta tatatggatt ttttttaaaa aggaaatact tgactggagt 37680
gtatatttat ctcttcatta tatagcacgc gtgttttcca atttttccac atcccatata 37740
atacaggatt ataatctcgt tcgaacatac gagaaagtgg ataaaacaat agttgatttt 37800
ttatctaggt tgccaaattt attccatatt ttagaatatg gggaaaatat tctacatatt 37860
tattctatgg atgatgctaa tacgaatatt ataatttttt ttctagatag agtattaaat 37920
attaataaga acgggtcatt tatacacaat ctcaggttat catcatccat taatataaaa 37980
gaatatgtat atcaattagt taataatgat catccagata ataggataag actaatgctt 38040
gaaaatggac gtagaacaag acattttttg tcctatatat cagatacagt taatatctat 38100
atatgtattt tatatagatg ccgaagacag ttacggttgt acattattac atagatgtat 38160
atatcactat aagaaatcag aatcagaatc agaatcatac aatgaattaa ttaagatatt 38220
gttaaataat ggatcagatg tagataaaaa agatacgtac ggaaacacac cttttatcct 38280
attatgtaaa cacgatatca acaacgtgga attgtttgag atatgtttag agaatgctaa 38340
tatagactct gtagacttta atagatatac acctcttcat tatgtctcat gtcgtaataa 38400
atatgatttt gtaaagttat taatttctaa aggagcaaat gttaatgcgc gtaataaatt 38460
cggaactact ccattttatt gtggaattat acacggtatc tcgcttataa aactatattt 38520
ggaatcagac acagagttag aaatagataa tgaacatata gttcgtcatt taataatttt 38580
tgatgctgtt gaatctttag attatctatt atccagagga gttattgata ttaactatcg 38640
tactatttac gacgctgtca gttataatgc gtataatacg ttggtctatc tattaaacag 38700
aaatggtgat tttgagacga ttactactag tggatgtaca tgtatttcgg aagcagtcgc 38760
aaacaacaac aaaataataa tggaagtact attgtctaaa cgaccatctt tgaaaattat 38820
gatacagtct atgatagcaa ttactaaaca taaacagcat aatgcagatt tattgaaaat 38880
gtgtataaaa tatactgcgt gtatgaccga ttatgatact cttatagatg tacaatcact 38940
acagcaatat aaatggtata ttttaagatg tttcgatgaa atagatatca tgaagagatg 39000
ttatataaaa aataaaactg tattccaatt agttttttgt atcaaagaca ttaatacttt 39060
aatgagatac ggtaaacatc cttctttcgt gaagtgcact agtctcgacg tatacggaag 39120
tcgtgtacgt aatatcatag catctattag atatcgtcag agattaatta gtctattatc 39180
caagaagctg gatcctggag ataaatggtc gtgttttcct aacgaaataa aatataacga 39240
taacgaactg tccacatatc taaaaatctt ataaacacta ttaaaatata aaatcacact 39300
acatcattgt ttccttttag tgctcgacag tgtatactat ttttaacgct cataaataaa 39360
aatgaaaacg atttccgttg ttacgttgtt atgcgtacta cctgctgttg tttattcaac 39420
atgtactgta cccactatga ataacgctaa attaacgtct accgaaacat cgtttaataa 39480
taaccagaaa gttacgttta catgtgatca gggatatcat tcttcggatc caaatgctgt 39540
ctgcgaaaca gataaatgga aatacgaaaa tccatgcaaa aaaatgtgca cagtttctga 39600
ttacatctct gaactatata ataaaccgct atacgaagtg aattccacca tgacactaag 39660
ttgcaacggc gaaacaaaat attttcgttg cgaagaaaaa aatggaaata cttcttggaa 39720
tgatactgtt acgtgtccta atgcggaatg tcaacctctt caattagaac acggatcgtg 39780
tcaaccagtt aaagaaaaat actcatttgg ggaatatata actatcaact gtgatgttgg 39840
atatgaggtt attggtgctt cgtacataag ttgtacagct aattcttgga atgttattcc 39900
atcatgtcaa caaaaatgtg atataccgtc tctatctaat ggattaattt ccggatctac 39960
attttctatc ggtggcgtta tacatcttag ttgtaaaagt ggttttatac taacgggatc 40020
tccatcatcc acatgtatcg acggtaaatg gaatcccata ctcccaacat gtgtacgatc 40080
taacgaaaaa tttgatccag tggatgatgg tcccgacgat gagacagatt tgagcaaact 40140
ctcgaaagac gttgtacaat atgaacaaga aatagaatcg ttagaagcaa cttatcatat 40200
aatcatagtg gcgttaacaa ttatgggcgt catattttta atctccgtta tagtattagt 40260
ttgttcctgt gacaaaaata atgaccaata taagttccat aaattgctac cgtgaatata 40320
aatccgttaa aataatgaat aattaataat taataattta ataacaaaca agtatcaaaa 40380
gattaaagac ttatagctag aatcaattga gatgtcttct tcagtggatg ttgatatcta 40440
cgatgccgtt agagcatttt tactcaggca ctattataac aagagattta ttgtgtatgg 40500
aagaagtaac gccatattac ataatatata caggctattt acaagatgcg ccgttatacc 40560
gttcgatgat atagtacgta ctatgccaaa tgaatcacgt gttaaacaat gggtgatgga 40620
tacacttaat ggtataatga tgaatgaacg cgatgtttct gtaagcgttg gcaccggaat 40680
actattcatg gaaatgtttt tcgattacaa taaaaatagt atcaacaatc aactaatgta 40740
tgatataatt aatagcgtat ctataattct agctaatgag agatatagaa gcgcttttaa 40800
cgacgatggt atatacatcc gtagaaatat gattaacaag ttgtacggat acgcatctct 40860
aactactatt ggcacgatcg ctggaggtgt ttgttattat ctgttgatgc atctagttag 40920
tttgtataaa taattatttc aatatactag ttaaaatttt aagattttaa atgtataaaa 40980
aactaataac gtttttattt gtaataggtg cattagcatc ctattcgaat aatgagtaca 41040
ctccgtttaa taaactgagt gtaaaactct atatagatgg agtagataat atagaaaatt 41100
catatactga tgataataat gaattggtgt taaattttaa agagtacaca atttctatta 41160
ttacagagtc atgcgacgtc ggatttgatt ccatagatat agatgttata aacgactata 41220
aaattattga tatgtctact attcaacgca gaggtcacac gtgtagaata tctaccaaat 41280
tatcatgcca ttatgataag tacccttata ttcacaaata tgatggtgat gagcgacaat 41340
attctattac tgcagaggga aaatgctata aaggaataaa atatgaaata agtatgatca 41400
acgatgatac tctattgaga aaacatactc ttaaaattgg atctacttat atatttgatc 41460
gtcatggaca tagtaataca tattattcaa aatatgattt ttaaaaattt aaaatatatt 41520
atcacttcag tgacagtagt caaataacaa acaacaccat gagatatatt ataattctcg 41580
cagttttgtt cattaatagt atacacgcta aaataactag ttataagttt gaatccgtca 41640
attttgattc caaaattgaa tggactgggg atggtctata caatatatcc cttaaaaatt 41700
atggcatcaa gacgtggcaa acaatgtata caaatgtacc agaaggaaca tacgacatat 41760
ccgcatttcc aaagaatgat ttcgtatctt tctgggttaa atttgaacaa ggcgattata 41820
aagtggaaga gtattgtacg ggaccaccga ctgtaacatt aactgaatac gacgaccatc 41880
cgtatgctac tagaggtagc aaaaagattc ctatttacaa acgcggtgac atgtgtgata 41940
tctacttgtt gtatacggct aacttcacat tcggagattc taaagaacca gtaccatatg 42000
atatcgatga ctacgattgc acgtctacag gttgcagcat agactttgtc acaacagaaa 42060
aagtgtgcgt gacagcacag ggagccacag aagggtttct cgaaaaaatt actccatgga 42120
gttcgaaagt atgtctgaca cctaaaaaga gtgtatatac atgcgcaatt agatccaaag 42180
aagatgttcc caatttcaag gacaaaatgg ccagagttat caagagaaaa tttaactaaa 42240
tttctcggta gcacatcaaa tgatgttacc acttttctta gcatgcttaa cttgactaaa 42300
tattcataac taatttttat taatgataca aaaacgaaat aaaactgcat attatacact 42360
ggttaacgcc cttataggct ctaaccattt tcaagatgag gtccctgatt atagtccttc 42420
tgttcccctc tatcatctac tccatgtcta ttagacgatg tgagaagact gaagaggaaa 42480
catggggatt gaaaataggg ttgtgtataa ttgccaaaga tttctatccc gaaagaactg 42540
attgcagtgt tcatctccca actgcaagtg aaggcaatgg attcagggat atacgaaaca 42600
ccgataaatt ataaaaaaag caatgtgtcc gctgtttccg ttaataatac tattttcgta 42660
actggcggat tattcataaa taactctaat agcacgatcg tggttaacaa tatggaaaaa 42720
cttgacattt ataaagacaa acaatggtcg attatagaaa tgcctatggc tagggtatat 42780
cacggcatcg actcgacatt tggaatgtta tattttgccg gaggtctatc cgttaccgaa 42840
caatatggta atttagagaa aaacaacgag atatcttgtt acaatcctag aacgaataag 42900
tggtttgata tttcatatac tatttataag atatccatat catcattgtg taaactaaat 42960
aacgtcttct atgtatttag taaggacatt ggatatgtgg aaaagtatga tggtctcccc 43020
gctataaagg cattatcaac ttctccttat tgattgaaaa tgaaaatata aatagttttt 43080
atgtatagca gtattaccct atagttttat tgcttactac taacatggat acagatacag 43140
atgttacaaa tgtagaagat atcatgaatg aaatagatag agagaaagaa gaaatactaa 43200
aaaatgtaga aattgaaaat aataaaaaca ttaacaagaa tcatcccaat gaatatatta 43260
gagaagcact cgttattaat acaagtagta atagtgattc cattgataaa gaagttatag 43320
aatgtatcag tcacgatgta ggaatataga tcatatctac taatttttat aatcaataca 43380
aaacataaaa aacaactcgt tattacatag caggcatgga atccttcaag tattgttttg 43440
ataacgatgg caagaaatgg attatcggaa atactttata ttctggtaat tcaatactct 43500
ataaggtcag aaaaaatttc actagttcgt tctacaatta cgtaatgaag atagatcaca 43560
aatcacacaa gccattgttg tctgaaatac gattctatat atctgtattg gatcctttga 43620
ctatcgacaa ctggacacgg gaacgtggta taaagtattt ggctattcca gatctgtatg 43680
gaattggaga aaccgatgat tatatgttct tcgttataaa gaatttggga agagtattcg 43740
ccccaaagga tactgaatca gtcttcgaag catgcgtcac tatgataaac acgttagagt 43800
ttatacactc tcgaggattt acccatggaa aaatagaacc gaggaatata ctgattagaa 43860
ataaacgtct ttcactaatt gactattcta gaactaacaa actatacaag agtggaaact 43920
cacatataga ttacaacgag gacatgataa cttcaggaaa tatcaattat atgtgtgtag 43980
acaatcatct tggagcaaca gtttcaaaac gaggagattt agaaatgttg ggatattgca 44040
tgatagaatg gttcggtggc aaacttccat ggaaaaacga aagtagtata aaagtaataa 44100
aacaaaaaaa agaatataaa aaatttatag ctactttctt tgaggactgt tttcctgaag 44160
gaaatgaacc tctggaatta gttagatata tagaattagt atacacgtta gattattctc 44220
aaactcctaa ttatgacaga ctacgtagac tgtttataca agattgaaat attctttttt 44280
tatagagtgt ggtagtgtta cggatatcta atattaatat tagactatct ctatcgcgct 44340
acacgaccaa tatcgattac tatggatatc ttctatgaaa ggagagaatg tattcatttc 44400
tccagcgtca atctcgtcag tattgacaat actgtattat ggagctaatg gatccactgc 44460
tgaacagcta tcaaaatatg tagaaaagga ggagaacacg gataaggtta gcgctcagaa 44520
tatctcattc aaatccatga ataaagtata tgggcgatat tctgccgtgt ttaaagattc 44580
ctttttgaga aaaattggcg ataagtttca aactgttgac ttcactgatt gtcgcactat 44640
agatgcaatc aacaagtgtg tagatatctt tactgagggg aaaatcaatc cactattgga 44700
tgaacaattg tctcctagca attagtgccg tatactttaa agcaaaatgg ttgacgccat 44760
tcgaaaagga atttaccagt gattatccct tttacgtatc accaacggaa atggtagacg 44820
taagtatgat gtctatgtac ggcgagctat ttaatcacgc atctgtaaaa gaatcattcg 44880
gtaacttttc aatcatagaa ctgccatatg ttggagatac tagtatgatg gtcattcttc 44940
cagacaagat tgatggatta gaatccatag aacaaaatct aacagataca aattttaaga 45000
aatggtgtaa ctctctggaa gctacgttta tcgatgttca cattcccaag tttaaggtaa 45060
caggctcgta taatctggtg gatactctag taaagtcagg actgacagag gtgttcggtt 45120
caactggaga ttatagcaat atgtgtaatt tagatgtgag tgtcgacgct atgatccaca 45180
aaacgtatat agatgtcaat gaagagtata cagaagcagc tgcagcaact tgtgcactgg 45240
tgtcagactg tgcatcaaca attacaaatg agttctgtgt agatcatccg ttcatctatg 45300
tgattaggca tgttgatgga aaaatttttt tcgttggtag atattgctct ccgacaacta 45360
attgttaacc atttttttta aaaaaataga aaaaacatgt ggtattagtg caggtcgtta 45420
ttcttccaat tgcaattggt aagatgacgg ccaactttag tacccacgtc ttttcaccac 45480
agcactgtgg atgtgacaga ctgaccagta ttgatgacgt caaacaatgt ttgactgaat 45540
atatttattg gtcgtcctat gcataccgca acaggcaatg cgctggacaa ttgtattcca 45600
cactcctctc ttttagagat gatgcggaat tagtgttcat cgacattcgc gagctggtaa 45660
aaaatatgcc gtgggatgat gtcaaagatt gtgtagaaat catccgttgt tatataccgg 45720
atgagcaaaa aaccatcatc ggactttgtg catatgctgc tacttactgg ggaggtgaag 45780
accatcccac tagtaacagt ctgaacgcat tgtttgtgat gcttgagatg ctaaattacg 45840
tggattataa catcatattc cggcgtatga attgatgagt tgtacatctt gacattttct 45900
tctttcttct cttctccctt tcccagaaac aaactttttt tacccactat aaaataaaat 45960
gagtatacta cctgttatat ttctttctat atttttttat tcttcattcg ttcagacttt 46020
taacgcgcct gaatgtatcg acaaagggca atattttgca tcattcatgg agttagaaaa 46080
cgagccagta atcttaccat gtcctcaaat aaatacgcta tcatccggat ataatatatt 46140
agatatttta tgggaaaaac gaggagcgga taatgataga attataccga tagataatgg 46200
tagcaatatg ctaattctga acccgacaca atcagactct ggtatttata tatgcattac 46260
cacgaacgaa acctactgtg acatgatgtc gttaaatttg acaatcgtgt ctgtctcaga 46320
atcaaatata gatcttatct cgtatccaca aatagtaaat gagagatcta ctggcgaaat 46380
ggtatgtccc aatattaatg catttattgc tagtaacgta aacgcagata ttatatggag 46440
cgggcatcga cgccttagaa ataagagact taaacaacgg acacctggaa ttattaccat 46500
agaagatgtt agaaaaaatg atgctggtta ttatacatgt gttttagaat atatatacgg 46560
tggcaaaaca tataacgtaa ccagaattgt aaaattagag gtacgggata aaataatacc 46620
ttctactatg caattaccag aaggtgttgt aacttcaata ggtagtaatt tgactattgc 46680
gtgtagagta tcgttgagac ctcccacaac ggatgcagac gtcttttgga taagtaatgg 46740
tatgtattac gaagaagatg atggggacgg agacggtaga ataagtgtag caaataaaat 46800
ctatatgacc gataagagac gtgttattac atcccggtta aacattaatc ctgtcaagga 46860
agaagatgct acaacgttta cgtgtatggc gtttactatt cctagcatca gcaaaacagt 46920
tactgttagt ataacgtgaa tgtatgttgt tacatttcca tgtcaattga gtttataaga 46980
atttttatac attatcttcc aacaaacaat tgacgaacgt attgctatga ttaactccca 47040
cgatactatg catattatta atcattaact tgcagactat acctagtgct attttgacat 47100
actcatgttc ttgtgtaatt gcggtatcta tattattaaa gtacgtaaat ctagctatag 47160
ttttattatt taattttaga taatataccg tctccttatt tttaaaaatt gccacatcct 47220
ttattaaatc atgaatggga atttctatgt catcgttaat atattgtgaa caacaagagc 47280
agatatctat aggaaagggt ggaatgcgat acattgatct atgtagtttt aaaacacacg 47340
cgaactttga agaatttata taaatcattc catcgataca tccttctatg ttgacatgta 47400
tatatccagg aattctttta ttaatgtcag gaaatgtata aactaaaaca ttgcccgaaa 47460
gcggtgcctc tatctgcgtt atatccgttc ttaacttaca aaatgtaacc aatacctttg 47520
catgacttgt tttgttcggc aacgttagtt taaacttgac gaatggatta attacaatag 47580
catgatccgc gcatctatta agttttttta ctttaacgcc cttgtatgtt tttacagaga 47640
ctttatctaa atttctagtg cttgtatgtg ttataaatat aacgggatat agaactgaat 47700
cacctacctt agatacccaa ttacatttta tcagatccag ataataaaca aattttgtcg 47760
ccctaactaa ttctatattg ttatatattt tacaattggt tatgatatca tgtaataact 47820
tggagtctaa cgcgcatcgt cgtacgttta tacaattgtg atttagtgta gtatatctac 47880
acatgtattt ttccgcacta tagtattctg gactagtgat aaaactatcg ttatatctgt 47940
cttcaatgaa ctcatcgaga tattgctctc tgtcatattc atacacctgc ataaactttc 48000
tagacatctt acaatccgtg ttattttagg atcatattta catatttacg ggtatatcaa 48060
agatgttaga ttagttaatg ggaatcgtct ataataatga atattaaaca attatatgag 48120
gacttttacc acaaagcatc ataaaaatga gtcgtcgtct gatttatgtt ttaaatatca 48180
accgcgaatc aactcataaa atacaagaga atgaaatata tacatatttt agtcattgca 48240
atatagacca tacttctaca gaacttgatt ttgtagttaa aaactatgat ctaaacagac 48300
gacaacctgt aactgggtat actgcactac actgctattt gtataataat tactttacaa 48360
acgatgtact gaagatatta ttaaatcatg gagtggatgt aacgatgaaa accagtagcg 48420
gacgtatgcc tgtttatata ttgcttacta gatgttgtaa tatttcacat gatgtagtga 48480
tagatatgat agacaaagat aaaaaccact tatcgcatag agactattcc aacctactac 48540
tagagtatat aaaatctcgt tacatgttat tgaaggaaga ggatatcgat gagaacatag 48600
tatccacttt attagataag ggaatcgatc ctaactttaa acaagacgga tatacagcgt 48660
tacattatta ttatttgtgt ctcgcacacg tttataaacc aggtgagtgt agaaaaccga 48720
taacgataaa aaaggccaag cgaattattt ctttgtttat acaacatgga gctaatctaa 48780
acgcgttaga taattgtggt aatacaccat tccatttgta tcttagtatt gaaatgtgta 48840
ataatattca tatgactaaa atgctgttga cttttaatcc gaatttcaaa atatgtaata 48900
atcatggatt aacgcctata ctatgttata taacttccga ctacatacaa cacgatattc 48960
ttgttatgtt aatacatcac tatgaaacaa atgttggaga aatgccgata gatgagcgtc 49020
gtataatcgt attcgagttt atcaaaacat attctacacg tccggcagat tcgataactt 49080
atttgatgaa taggtttaaa aatatagata tttatacccg ctatgaagga aagacattat 49140
tacacgtagc atgtgaatat aataatacac acgtaataga ttatcttata cgtatcaacg 49200
gagatataaa tgcgttaacc gacaataaca aacacgctac acaactcatt atagataaca 49260
aagaaaattc cccatatacc attaattgtt tactgtatat acttagatat attgtagata 49320
agaatgtgat aagatcgttg gtggatcaac ttccatctct acctatcttc gatataaaat 49380
catttgagaa attcatatcc tactgtatac ttttagatga cacattttac aatagacacg 49440
ttaggaatcg caattctaaa acgtatcgat acgcattttc aaaatacatg tcgtttgata 49500
aatacgatgg tataataact aaatgtcata aagaaacaat attgctcaaa ctatccactg 49560
ttctagacac tacactatat gcagttttaa gatgccataa ttcgaaaaag ttaagaagat 49620
acctcaacga gttaaaaaaa tataataacg ataagtcctt taaaatatat tctaatatta 49680
tgaatgagag ataccttaat gtatattata aagatatgta cgtgtcaaag gtatatgata 49740
aactatttcc tgttttcaca gataaaaatt gtctactaac attactacct tcagaaatta 49800
tatacgaaat attatacatg ctgacaatta acgatcttta taatatatcg tatccaccta 49860
ccaaagtata gttgtatttt tctcatgcga tgtgtgtaaa aaaactgata ttatataaat 49920
attttagtgc cgtataatga agatgacgat gaaaatgatg gtacatatat atttcgtatc 49980
attattgtta ttgctattcc acagttacgc catagacatc gaaaatgaaa tcacagaatt 50040
cttcaataaa atgagagata ctctaccagc taaagactct aaatggttga atccagcatg 50100
tatgttcgga ggcacaatga atgatatagc cgctctagga gagccattca gcgcaaagtg 50160
tcctcctatt gaagacagtc ttttatcgca cagatataaa gactatgtgg ttaaatggga 50220
gaggctagaa aaaaatagac ggcgacaggt ttctaataaa cgtgttaaac atggtgattt 50280
atggatagcc aactatacat ctaaattcag taaccgtagg tatttgtgta ccgtaactac 50340
aaagaatggt gactgtgttc agggtatagt tagatctcat attaaaaaac ctccttcatg 50400
cattccaaaa acatatgaac taggtactca tgataagtat ggcatagact tatactgtgg 50460
aattctttac gcaaaacatt ataataatat aacttggtat aaagataata aggaaattaa 50520
tatcgacgat attaagtatt cacaaacggg aaagaaatta attattcata atccagagtt 50580
agaagatagt ggaagataca actgttacgt tcattacgac gacgttagaa tcaagatgta 50640
aaatacttac ggttataccg tcgcaagacc acaggtttaa actaatacta gatccaaaaa 50700
tcaacgtaac gataggagaa cctgccaata taacatgcac tgctgtgtca acgtcattat 50760
tgattgacga tgtactgatt gaatgggaaa atccatccgg atggcttata ggattcgatt 50820
ttgatgtata ctctgtttta actagtagag gcggtatcac cgaggcgacc ttgtactttg 50880
aaaatgttac tgaagaatat ataggtaata catataaatg tcgtggacac aactattatt 50940
ttgaaaaaac ccttacaact acagtagtat tggagtaaat acacaatgca tttttatata 51000
cattactgaa taattattat tattatttat atcgtatttg tgctataacg cgactatcta 51060
ggtatttgta tctcaccgat agagaacata taaatgtaga ctctattaaa cagttgtgta 51120
aaatatcaga tcctaataga tgtggatgta cggctttaga aatgagttca ttaaaatatg 51180
tgatatcaac ggaacatatt tatataatta tactattgct gttagtataa ttattgattc 51240
cacggaagaa ctaccaacag ttactccaat tacaacaaca tataattata ctatcgatga 51300
tagcactact gaagaactac aagtgactcc tcatatggat ctccatcgat gatacatgta 51360
ttaaaatact ttccgaataa gtcttttaaa tattgtatta attatgaaaa actatgctat 51420
gcgagtatga tacgatacta gattttatct ctagcgagag atgtcgttag aatcatttat 51480
caacgaatat cgataacatg tgtcatttat acgttaaagt ctgtccgtct tctctattgt 51540
ttagactgtt tgtagaatgc tgtgatataa acaaactagt agacacaaat atttaactca 51600
tgatgaagtt gagaatgata tgctttagct aatataaaaa tatattaatc cactatatat 51660
tctagacttg atttaaaacc gataaactac tactacgtac tgtataagtt aggagcagac 51720
cctaattatg tagatgatag aggtaatact tctgcatcta tatgtccact tatgagaaaa 51780
cgtcatttaa taagatgcat cgtgaaaaga aatttattaa agagttggta aaatatgaaa 51840
ccgaaagtaa ataatatagg aaatacacct ctacataact acgtatctca atatgatatc 51900
actctcattc ctcatccaca acccattaaa aaatggaaat taaagccctc tattagcata 51960
aacggctaca ggtctacctt tacaatggcc tttccttgtg cccagttcag accctgtcat 52020
tgccacgcta ctaaggactc cctgaatacc gtggccgacg tcagacattg tctgactgaa 52080
tacatcctgt gggtttctca tagatggacc catagagaaa gcgcagggtc tctctacagg 52140
cttctcatct ctttcagaac tgatgcaacg gagctctttg gtggtgagtt gaaggattca 52200
cttccgtgga gatcattaaa tgactccatg aaaaccgccg aagaacttcg tgcaatcatt 52260
ggactttgta ctcaatcagc tatcgtctct ggaagagtct tcaacgataa gtatatcgac 52320
atactactta tgctgcgaaa gattctgaac gagaacgact atctcaccct cttggatcat 52380
atccgcactg ctaaatacta aatctccttc atgctctctc actacacttt ttatcatctt 52440
atgaggaata attagcacca gaatagctat ggattgcaca tgtattctat gtcgtctact 52500
ggatgaagat gtgacgtaca aaaaaataaa actagaaatt gaaacgtgtc acaacttatc 52560
aaaacatata gatagacgag gaaacaatgc gctacattgt tacgtctcca ataaatgcga 52620
tacagacatt aagattgttc gactgttact ctctcgcgga gtcgagagac tttgtagaaa 52680
caacgaagga ttaactccgc taggagcata cagtaagcat agatacgtaa aatctcagat 52740
tgtgcatcta ctgatatcca gctattcgaa ttcctctaac gaactcaagt cgaatataaa 52800
tgatttcgac ttacgtctgc taaaatacct aattgtggat aaacggatac gtccgtccaa 52860
gaatacgaat tatgcaatca atggtctcgg attggtggat atatacgtaa cgacgcctaa 52920
tccgagacca gaagtattgc tatggcttct taaatcagaa tgttacagca ccggttacgt 52980
atttcgtacc tgtatgtaca acagtgatat gtgtaagaac tctcttcatt actatatatc 53040
gtctcataga gaatctctat ccaaggatgt aattaaatgt ttgatcgata acaatgtttc 53100
catccaatac tactggtctt gctcaaccat agatatagag attattaata aaggatgtgg 53160
acacgtgtag agtatacgac gtcagcccta tattagaggc gtattatcta aacaagcgat 53220
ttagagtaac cccatataat gtagacatgg aaatcgttaa tcttcttatt gagagacgtc 53280
atactcttgt cgacgtaatg cgtagtatta cttcgtacga ttccagagaa tataaccact 53340
acatcatcga taacattcta aagagattta gacaacagga tgaatccatc gtacaagcca 53400
tactgataaa ctacttacat tacggcgata tggtaagtat acctatcatt caatgcatgt 53460
tggataagac gacggacaac aactttgtta ataataatct cgtcgatgta aacgtcgtaa 53520
ggtttatcgt ggaaaatatg gacacgcggc tgtaaatcac atatctaaca atggccgtct 53580
atgtatgtac ggtctgatat tatcgagatt taataattgc gggtatcact gttatgaaga 53640
tgtatttgat atactaagca agtacatgga tgatatagat atgatcgata actctactat 53700
attacgcggt cgatgtcaat aatatacaat ttgcaaagcg gttattggaa tatggagcga 53760
gtgtcacgct cgataatcaa tacggccatc cagaaaagca gttaccaaag agaagctagt 53820
tgatttatta ctgagttacc atcccactct agagactatg attgacgcat ttaatagaga 53880
tatacgctat ctatatcctg aaccattatt cgcctgtatc agatacgcct taatcctaga 53940
tgatgatttt ccttctaaag taagtatgat atcgccggtc gtcataagga actaaagcgc 54000
tatagagcag acattaatag aatgaagaat gcctacatat caggcgtctc catgtttgat 54060
atattattta aacgaagcaa acgccacaga ttgagatacg caaagaacaa tgagaggatc 54120
gactccatta aataatttat catggagtga taatgtcctg tttccatggc atattacaaa 54180
atcgattccg tccaagatga taaaaacatt taccggcatc ataaacacgg agtttatttt 54240
atatgtctcg cataaacatt actaaaaaaa tatattgttc ggttttcttt cacatcttta 54300
attatgaaaa agtaaatcat tatgagatgg acgcatcgtt cgcgacagta tgtggtacat 54360
acctaacgta tttatggacg acggtaagaa tgaaggtcac gtttctgtca acaatgtcga 54420
cgcgatcgtg taacacgact cacaatagaa tctgtgaatg ctctcccgat catggatgca 54480
aggcatgtgt ttcccaaaca aaatgtggaa taggatacgg agtatccgga gacgtcatct 54540
gttctccgtg tggtctcgga acatattctc acaccgtctc ttccgcagat aaatgcgaac 54600
ccgtacccag aaataccttt aactatatcg atgtggaaat taacctgtat ccagttaacg 54660
acacatcgtg tactcggacg accactaccg gtctcagcga atccatctca acgtcggaac 54720
taactattac tatgaatcat aaagactgcg atcccgtctt cttaataagg tagcgacttc 54780
aggtttcttt acaggagaaa ggtgtgcact ctgaatttcg agattaaatg caataacaaa 54840
gattcttcct ccaaacagtt aacgaaagca aagaatgata ctatcatgcc gcattcggag 54900
acagtaactc tagcgtcgac atctatatac tatatagtaa taccaatact caagactacg 54960
aaactgatac aatctcttat catgtgggta atgtagccat atgcccggta gttgcgatat 55020
acataaactg atcactaatt ccaaacccac ccgcttttta tagtaagttt ttcacccata 55080
aatacaataa ttaatttctc gtaaaagtag aaaatatatt ctaatttatt gcacggtaag 55140
gaagtagaat cataaagaac agtactcaat caatagcaat catgaaacaa tatatcgtac 55200
tggcatgcat gtgcctgcca gtcttcagca atcatcctca tcgtgtacgg aagaagaaaa 55260
caaacatcat atgggaatcg atgttattat caaagtcaca aagcaagacc aaacaccgac 55320
cgatgataag atttgccaat ccgtaacgga aattacagag tccgagtcag atccagatcc 55380
cgaggtggaa tcagtcgagg atgtagatcc tcctaccact tattactcca tcatcggtgg 55440
aggtctgaga atgaactttg gattcaccaa atgtcctcag attaaatcca tctcagaatc 55500
cgctgatgga aagactgtga ggtgtctatc gacatcagat gtagcgaaga agagaaagac 55560
agcgacatca agacccatcc agtactcggg tctaacatct ctcataagaa agtgagttac 55620
gaagatatca tcggttcaac gatcgtcgat acaaaatgtg tcaagaatct agagtttagc 55680
gttcgtatcg gagacatgtg caaggaatca tctgaacttg aggtcaagta tgtcgacgga 55740
tcggcatctg aaggtgcaac cgatgatact tcactcatcg attcaacaaa actcaaagcg 55800
tgtgtctgaa tcgataactc tattcatctg aaattggatg agtagggtta atcgaacgat 55860
tcaggcacac cacgaattaa aaaagtgtac cggacactat attccggttt gcaaaacaaa 55920
aagttacctc tcgcgacttc ttctttttct gtctcaatag tgtgatacga ttatgacact 55980
attcctattt cctttcaggg tatcacaaaa atattaaacc tctttctgat ggtctcatac 56040
aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaatatt tttattctct 56100
ttctctcttt gatggtctca taaaatattt ttattctctt tctctctttg atggtctcat 56160
aaaaaatatt tttattctct ttctctcttt gatggtctca taaaatattt ttattctctt 56220
tctctctttg atggtctcat aaaaaatatt tttattctct ttctctcttt gatggtctca 56280
taaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc tctttctctc 56340
ttcaatggag tcataaaata tttttattct ctttctctct tcgatggtct cacaaaaata 56400
ttaaacctct ttctgatggt gtcactaaaa tatttttatt ctctttctct cttcaatgga 56460
gtcataaaat atttttattc tctttctctc tttgatggtc tcacaaaaat atttttattc 56520
tctttctctc tttgatggtc tcacaaaaat atttttattc tctttctctc tttgatggtc 56580
tcacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 56640
aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 56700
ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 56760
tctctttctc tctttgatgg tctcataaaa aatattaaac ctctttctga tggtgtcact 56820
aaaatatttt tattctcatt ctctcttcaa tggagtcata aaatattttt attctctttc 56880
tctcttcgat ggtctcacaa aaatattaaa cctctttctg atggtgtcac taaaatattt 56940
ttattctcat tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga 57000
tggtctcaca aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca 57060
ttctctcttc aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat 57120
aaaaaaagtt ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa 57180
tattaaacct ctttctgatg gtgtcactaa aatattttta ttctctttct ctcttcaatg 57240
gagtcataaa atatttttat tctctttctc tcttcgatgg tctcacaaaa atattaaacc 57300
tctttctgat ggtgtcacta aaatattttt attctcattc tctcttcaat ggagtcataa 57360
aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 57420
tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 57480
ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 57540
ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 57600
ttgatggtct cataaaaaat attaaacctc tttctgatgg tgtcactaaa atatttttat 57660
tctcattctc tcttcaatgg agtcataaaa tatttttatt ctctttctct cttcgatggt 57720
ctcacaaaaa tattaaacct ctttctgatg gtgtcactaa aatattttta ttctcattct 57780
ctcttcaatg gagtcataaa atatttttat tctctttctc tctttgatgg tctcataaaa 57840
aaagttttac aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 57900
ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 57960
aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 58020
ttttattctc tttctctctt tgatggtctc acaaaaatat taaacctctt tctgatggag 58080
tcgtaaaaaa gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt 58140
ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt 58200
aaacctcttt ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca 58260
ctaaaatatt ttttattctc tttctgatgc atcaactatt tcttaaacaa taacgtccaa 58320
caacatatac tcgtcgagct tatcaacatc ccctatgccc atctaggtta ccagacaatt 58380
gtatatcata aaataatgtt tataattttt acaaaaatat ttttattctc tttctctctt 58440
tgatggtctc ataaaaaaag ttttacaaaa atatttttat tctctttctc tctttgatgg 58500
tctcataaaa aatattaaac ctctttctga tggtgtcact aaaatatttt tattctcatt 58560
ctctcttcaa tggagtcata aaatattttt attctctttc tctcttcgat ggtctcacaa 58620
aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctcat tctctcttca 58680
atggagtcat aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt 58740
tacaaaaata tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa 58800
aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 58860
tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 58920
ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 58980
ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 59040
ttgatggtct cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg 59100
gtctcataaa aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctctt 59160
tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga tggtctcaca 59220
aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca ttctctcttc 59280
aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 59340
ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 59400
aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 59460
ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 59520
tctctttctc tctttgatgg tctcataaaa aaagttttac aaaaatattt ttattctctt 59580
tctctctttg atggtctcat aaaaaatatt aaacctcttt ctgatggtgt cactaaaata 59640
tttttattct ctttctctct tcaatggagt cataaaatat ttttattctc tttctctctt 59700
cgatggtctc acaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc 59760
tctttctctc ttcaatggag tcataaaata tttttattct ctttctctct ttgatggtct 59820
cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg gtctcataaa 59880
aaaagtttta caaaaatatt tttattctct ttctctcttt gatggtctca taaaaaaagt 59940
tttacaaaaa tatttttatt ctctttctct ctttgatggt ctcataaaaa aagttttaca 60000
aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt tacaaaaata 60060
tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa aatattttta 60120
ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt tttattctct 60180
ttctctcttt gatggtctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60240
atttttattc tcattttctc tttctctctt caatggagtc ataaaatatt tttattctct 60300
ttctctcttt gatggtctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60360
atttttattc tcattctctc ttcaatggag tcataaaaaa gttttatctc tttctctctt 60420
cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc 60480
tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatgcat caactatttc 60540
ttaaacaata acgtccaaca acatatactc atcccctatg cccatctagg ttaccagaca 60600
attgtatatc ataaaataat gtttataatt tacacgttaa aatcatataa taaaacgtag 60660
atcgtataat attttttggt atataaatga tctagtaaaa tccatgtagg ggatactgct 60720
cacatttttt ctttggtaca aaatttcaca caagttttta tacagacaaa ttcttgtcca 60780
tatattttaa aacattgact tttgtactaa gaaaaatatc tagactaact atctctttct 60840
ctttctctct tcgatggtct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 60900
tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 60960
ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 61020
agttttatct ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag 61080
tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat taaacctctt 61140
tctgatggtg tcactaaaat atttttattc tctttctctc ttcgatggtc tcacaaaaat 61200
attaaacctc tttctgatgg agtcgtaaaa aagttttatc tctttctcct tcgatggtct 61260
cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 61320
tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 61380
ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa 61440
gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt ctgatggagt 61500
cgtaaaaaag ttttatctct ttctccttcg atggtctcac aaaaatatta aacctctttc 61560
tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac aaaaatatta 61620
aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac 61680
aaaaatatta aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctccttcga 61740
tggtctcaca aaaatattaa acctctttct gatagtctct ataaagcgat tgatttttct 61800
taccctctag agtttcctac ggtcgttggt cacacatttt tttctagaca ctaaataaat 61860
agtaagatta aattaattat aaaattatgt atataatatt aattataaaa ttatgtatat 61920
gatttactaa ctttagttag ataaattaat aatacataaa ttttagtata ttaatattat 61980
aaattaataa tacataaatt ttagtatatt aatattatat tttaaatatt tatttagtgt 62040
ctagaaaaaa aggccggcct agcaggcc 62068
<210> 16
<211> 66679
<212> DNA
<213> Artificial Sequence
<220>
<223> sVAC fragment 1
<400> 16
tttttttcta gacactaaat aaaatattta aaatataata ttaatgtact aaaacttata 60
tattattaat ttatctaact aaagttagta aattatatat ataattttat aattaattta 120
attttactaa ttttatttag tgtctagaaa aaaatgtgtg acccatgact gtaggaaact 180
ctagagtgta agaaagatcg atcgctttat agagaccatc agaaagaggt ttaatatttt 240
tgtgagacca tcgaagagag aaagagataa aactttttta cgactccatc agaaagaggt 300
ttaatatttt tgtgagacca tcgaagagag aaagagataa aactttttta cgactccatc 360
agaaagaggt ttaatatttt tgtgagacca tcgaaggaga aagagataaa acttttttac 420
gactccatca gaaagaggtt taatattttt gtgagaccat cgaaggagaa agagataaaa 480
cttttttacg actccatcag aaagaggttt aatatttttg tgagaccatc gaagagagaa 540
agagataaaa cttttttacg actccatcag aaagaggttt aatatttttg tgagaccatc 600
gaagagagaa agagataaaa cttttttacg actccatcag aaagaggttt aatatttttg 660
tgagaccatc gaaggagaaa gagataaaac ttttttacga ctccatcaga aagaggttta 720
atatttttgt gagaccatcg aagagagaaa gagataaaac ttttttacga ctccatcaga 780
aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac ttttttacga 840
ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac 900
ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa 960
gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg 1020
aagagagaaa gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt 1080
gagaccatcg aagagagaaa gagaaagaga tagttgatct agatattttt cttagtacaa 1140
aagtcaatgt tttaaaatat atggacaaga atttgtctgt ataaaaactt gtgtgaaatt 1200
ttgtaccaaa gaaaaaatgt gagcagtatc ccctacatgg attttactag atcatttata 1260
taccaaaaaa tattatacga tctacgtttt attatatgat tttaacgtgt aaattataaa 1320
cattatttta tgatatacaa ttgtctggta acctagatgg gcatagggga tgttgataag 1380
ctcgacgagt atatgttgtt ggacgttatt gtttaagaaa tagttgatgc atcagaaaga 1440
gaataaaaaa tattttagtg agaccatcga agagagaaag agataaaact tttttacgac 1500
tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact 1560
tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 1620
agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 1680
agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 1740
agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa 1800
tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa 1860
agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac 1920
tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact 1980
tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 2040
agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 2100
agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 2160
agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa 2220
tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa 2280
agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac 2340
tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact 2400
tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 2460
agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 2520
agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 2580
agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa 2640
tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa 2700
agaggtttaa tatttttgtg agaccatcga agagagaaag agaataaaaa tattttatga 2760
ctccattgaa gagagaaaga gaaaatgaga atgagaataa aaatatttta gtgacaccat 2820
cagaaagagg tttaatattt ttgtgagacc atcgaagaga gaaagagaat aaaaatattt 2880
tatgactcca ttgaagagag aaagagaaaa tgagaatgag aataaaaata ttttagtgac 2940
accatcagaa agaggtttaa tattttttat gagaccatca aagagagaaa gagaataaaa 3000
atatttttgt aaaacttttt ttatgagacc atcaaagaga gaaagagaat aaaaatattt 3060
ttgtaaaact ttttttatga gaccatcaaa gagagaaaga gaataaaaat atttttgtaa 3120
aacttttttt atgagaccat caaagagaga aagagaataa aaatattttt gtaaaacttt 3180
ttttatgaga ccatcaaaga gagaaagaga ataaaaatat ttttgtaaaa ctttttttat 3240
gagaccatca aagagagaaa gagaataaaa atatttttgt aaaacttttt ttatgagacc 3300
atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga gaccatcaaa 3360
gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat cagaaagagg 3420
tttaatattt ttgtgatacc ctgaaaggaa ataggaatag gaataggaat agtgtcataa 3480
tcgtatcaca ctattgagac agaaaaagaa gaagtcgcga gaggtaactt tttgtgaatg 3540
tagttaagaa catttttgtt ttgcaaaccg gaatatagtg tccggtacac ttttttaatt 3600
cgtggtgtgc ctgaatcgtt cgattaaccc tactcatcca atttcagatg aatagagtta 3660
tcgattcaga cacacgcttt gagttttgtt gaatcgatga gtgaagtatc atcggttgca 3720
ccttcagatg ccgatccgtc gacatactta aatccatcct tgacctcaag ttcagatgat 3780
tccttgcaca tgtctccgat acgaacgcta aactctagat tcttgacaca ttttgtatcg 3840
acgatcgttg aaccgatgat atcttcgtaa ctcactttct tatgagagat gttagacccg 3900
agtactggat gggtcttgat gtcgctgtct ttctcttctt cgctacatct gatgtcgata 3960
gacacctcac agtctttgat catagccaga gcttcttcat gagtgatcgc gggagagtcc 4020
ttaccttgtc ctggggacac gctggacaat ctagcattca ctgtgtttcc atcagcggat 4080
tctgagatgg atttaatctg aggacatttg gtgaatccaa agttcattct cagacctcca 4140
ccgatgatgg agtaataagt ggtaggagga tctacatcct cgactgatgt ggaatcatct 4200
tctgattcca cctcgggatc tggatctgac tcggactctg taatttccgt tacggattgg 4260
caaatcttat cattggtcgg tgtttggtct tgctttgtga ctttgataat aacatcgatt 4320
cccatatgat gtttgttttc ttcttccgta cacgaggagg aggatgagga tgattgctga 4380
agactggcag gcacatgcat gccaggacga tatattgttt catgattgct attgattgag 4440
tactgttctt tatgattcta cttccttacc gtgcaataaa ttagaatata ttttctactt 4500
ttacgagaaa ttaattattg tatttattat ttatgggtga aaaacttact ataaaaagcg 4560
ggtgggtttg gaattagtga tcagtttatg tatatcgcaa ctaccgggca tatggctatc 4620
gacatcgaga acattaccca catgataaga gattgtatca gtttcgtagt cttgagtatt 4680
ggtattacta tatagtatat agatgtcgac gctagataga cagtctccga atgcggcatg 4740
ataccgtcat cattctttgc tttcgttaac tgtttggagg aaaaattttt gttattgcat 4800
ttaatctcga aattcagagt gcacaccttt ctcctgtaaa gaaacctgaa gttgctacct 4860
tattaaggac ggagaagtat tcctcacgaa atacgggatt acagtcttta tgattcatag 4920
taatagttag ttccgacgtt gagatggatt cgctgagacc ggtagtggtc gttaactgga 4980
tacagattaa tttccacatc gatatagtta aaggtattac tgggtacggg ttcgcattta 5040
tctgcggaag agacggtgtg agaatatgtt ccgagaccac acggagaaca gatgacgtct 5100
ccggatactc cgtatcctat tccacatttt gtttgggaaa cacatgcctt gcatccggat 5160
gatcctttga gaagacaata atatccggga gagcattcac agattctatt gtgagtcgtg 5220
ttacacggtc gcgtcttccg ttacaactta gacaagcggg taaatgatta ttgcgagatg 5280
tgaaggtacc cgaaccacac ggcgtacatt gtgtgttagt cttgctatcg cataatctgg 5340
aagcgtatgt tcccggacac aaattatggc gtttgtattc gttgtcttta cactttccat 5400
cggatggtgc atgcggtgct atatctcttc cgtttattat tatacatgag agaaacaata 5460
tatacgagta taatacggac ttcatgattt aataatgtag taatcgtcgt cttgttcctg 5520
tttcctactt ctccaatcat atagatattt tctttctatc atggataata tttgtaatgg 5580
ttcttttcgt acaacatact gtttagatga tattgcgcat aatttccgga ggcaaatacg 5640
atagtctaga ttgaccgatg gtagactcta atttattgag tgctttgtcg acgagtttac 5700
ttttacgctc catcgataga tggcactgtt ctatgagatc gtcgtacatg ggaaatgaaa 5760
tgtgactgtc tgaatgtatg gctttaagat agctgtgata ccgtatacag gtcggtgtcg 5820
gagattcgaa tctctttaag gcgacttatg tcacgatgat ggaatctatc ttatcgaatg 5880
atatattttt cataaataca cttttatagt cctcgtttaa acagaattta ctatgtagtt 5940
ccgcgaatga ctcgtccctt aataggcagt aggctattat cttctttacg tagtaatcgt 6000
cgtagggaga gacatcttgt agaacaacga tttaatcata ggtagagata ctttcagtct 6060
gtggtggatg atgtcattca caacatccgc cttgtatatg atgtttctgt tttcaaacac 6120
caagtcgaat accgtcttta gtcggaaggt tgatgtcgta tccgatgtat gaggcaacat 6180
tgttgttaca attttgaaag gcggtattat agtattcgtc tttctgaatg tcgaacctat 6240
ctagtagata ccgtagtata ttgagagtgt atccttgatt atgttttatg aatagataaa 6300
gtagatgttg tccttcttcc ttttgttcgt gccaattgag taacattatg agaatatgac 6360
ctgttgcaca atcgttccat gatgggtgta caatcaagat tattacgtat cctcgtatcg 6420
gctcctcgag ataaaagagc atacaccaca cgaggactat gtttggtata ctgttgaagg 6480
taagtgtgta accgcgttaa tgtttgctcc ataatctatt atcgcgtaga tgaatcgctt 6540
ctcggctcgc atcttagtgt gacttaactt gtaataattg cttttgtaga acgtggatat 6600
gtgtttacag tagtaatgaa gagaagtgag ttcatcctcg tcggatcctt tgtacagaac 6660
gtaatagttt aagctcccat tgaatttata tctaagataa cacagcaata gatcggatga 6720
tttactaaag tcatcaatgg tgtccgttag tatatcaaag atcttgttat cgattgatag 6780
tggtgtcctt tttcatcctt gctatcaaag ttacgcatgc cgtggtgtaa caatatcttt 6840
aatacagatg gattaaatcg tgtattcatc gtatagcaat gtaatggaga gttacctcgt 6900
ttattcagat cgcagtgttt aataactagc ttaaacagat gagacgatgt atccacatca 6960
aagaacgtga aatacatatg acagacattg ttgacagaaa cgtgaccttc attcttaccg 7020
tcgtccataa atacgttagg tatgtaccac atactgtcgc gaacgatgcg tacaatctcg 7080
tccatctcat aatgatttac tttttcataa ttaaagatgt gaaagaaaaa cagaacaata 7140
tattttttta gtaatgttta tgcgagacat ataaaataaa ctccgtgttt atgatcattt 7200
ttaacagcaa cacattcaat attgtattgt tatttttata ttatttacac aattaacaat 7260
atattattag tttatattac tgaattaata atataaaatt cccaatcttg tcataaacac 7320
acactgagaa acagcataaa cacaaaatcc atcaaaaatg tcgatgaaat atctgatgtt 7380
gttgttcgct gctatgataa tcagatcatt cgccgatagt ggtaacgcta tcgaaacgac 7440
atcgccagaa attacaaacg ctacaacaga tattccagct atcagattat gcggtccaga 7500
gggagatgga tattgtttac acggtgactg tatccacgct agagatattg acggtatgta 7560
ttgtagatgc tctcatggtt atacaggcat tagatgtcag catgtagtat tagtagacta 7620
tcaacgttca gaaaacccaa acactacaac gtcatatatc ccatctcccg gtattatgct 7680
tgtattagta ggcattatta ttattacgtg ttgtctatta tctgtttata ggttcactcg 7740
acgaactaaa ctacctatac aagatatggt tgtgccataa tttttataaa tttttttatg 7800
agtattttta caaaaaaaat gtataaagtg tatgtcttat gtatatttat aaaaatgcta 7860
agtatgcgat gtatctatgt tatttgtatt tatctaaaca atacctctac ctctagatat 7920
tatacaaaaa ttttttattt cggcatatta aagtaaaatc tagttacctt gaaaatgaat 7980
acagtgggtg gttccgtatc accagtaaga acataatagt cgaatacagt atccgattga 8040
gattttgcat acaatactag tctagaaaga aatttgtaat catcttctgt gacgggagtc 8100
catatatctg tatcatcgtc tagtttatca gtgtcccatg ctatattcct gttatcatca 8160
ttagttaatg aaaataactc tcgtgcttca gaaaagtcaa atattgtatc catacataca 8220
tctccaaaac tatcgcttat acgtttatct ttaacgatac ctatacctag atggttattt 8280
actaacagac attttccaga tctattgact ataactccta tagtttccac atcaaccaag 8340
taatgatcat ctattgttat ataacaataa cataactctt ttccattttt atcagtatgt 8400
atatctatat caacgtcgtc gttgtagtga atagtagtca ttgatctatt atatgaaacg 8460
gatatgtcta gaacggcaat tgttttacgt ccagttaaca ctttctttga tttaaagtct 8520
agagtctttg caaacataat atccttatcc gactttatat ttcctgtagg gtggtataat 8580
tttattttgc ctccacatat cggtgtttcc aaatatatta ctagacaata ttccatatag 8640
ttattagtta agggtaccca attagaacac gtacgcttat tatcatcatt tggatcgtat 8700
ttcataaaag ttattgtact atcgatgtca acacattcta cattttttaa tcgtctatat 8760
agtatttttc tgatattttc tataatatca gaattgtctt ccatcggaag ttgtatacta 8820
tcggaatcag ttacatgttt aaataattct ctgatgtcat tccttataca atcaaattca 8880
ttattaaaca gtttaatagt ctgtagacct ttatcgtcgt aaatatccat tgtcttatta 8940
gttacgctta tttttatgtg ttttacgttg ctttattata ttttataaga atgattgttt 9000
gacgaatcac gagaactatt aagacacatt attaggtata tattataaaa aagtttttga 9060
ttacgatgtt ataagaggaa agaggacaca ttaacatcat acatcaatta actacattct 9120
tataacatcg taatcaaaag aattgcaatt ttgatgtata acaactgtca atgggttatg 9180
gaattgtata ttacatatta tacggtatgt tggtaacgac aaataccgat cggtaattgt 9240
ctgccggtgt aatagaatta tatatatcta tctattacac cggctgagta tgcataataa 9300
taagttgtgg tagtatgatc tccatattta taatttagga ctttgtattc agtatttttg 9360
gaatcataaa aaataaaaaa aagttttact aatttaaaat ttaaaaagta tttacatttt 9420
tttcactgtt tagtcgcgga tatggaattc gatcctgcca aaatcaatac atcatctata 9480
gatcatgtaa caatattaca atacatagat gaaccaaatg atataagact aacagtatgc 9540
attatccgaa atattaataa cattacatat tatatcaata tcacaaaaat aaatacacat 9600
ttggctaatc aatttcgggc ttggaaaaaa cgtatcgccg gaagggacta tatgactaac 9660
ttatctagag atacaggaat acaacaatca aaacttactg aaactatacg taactgtcaa 9720
aaaaatagaa acatatatgg tctatatata cactacaatt tagttattaa tgtggttatt 9780
gattggataa ccgatgtgat tgttcaatca atattaagag ggttggtaaa ttggtacata 9840
gctaataata cctatacacc caataataca acaaccattt ctgagttgga tatcatcaaa 9900
atactggata aatacgagga cgtgtataga gtaagtaaag aaaaagaatg tggaatttgc 9960
tatgaagttg tttactcaaa acgatagata ctttggttta ttggattcgt gtactcatat 10020
attttgcata acatgcatca atatatggca taaaacacga agagaaaccg gtgcgtcgga 10080
taattgtcct atatgtcgta cccgttttag aaacataaca atgagcaagt tctataagct 10140
agttaactaa taaataaaaa gtttaatttg ttgacgacgt atgtcgttat ttttctcgta 10200
tgaaagatta aattcaattc aattcgttgt ttctaatata atctgccgta ttggatggat 10260
tctcaagaca attgcattta gattatatta tcatgaataa aaatagtagc acgcactact 10320
tcagccaaat attctttttt gaaacgccat ctatcgtagt gaggacacaa gtgaacctat 10380
aattatcaaa tttattagta tcagtcacat gaaggacttt ctgtagagtg acgattctac 10440
catctatggt actaacggtt tcatcctcct tgataccctc acccaaatgt tctataaatt 10500
tagcatcctc gtccgatctc atatcctttg ccaaccaata catgtagcta aaattaggca 10560
taaatttcac acatccagtg caacgaaatt ctccagaaga tgttacgatg tttaggttag 10620
gacatttgat ttcgtcggca ttaacatatg ggtgaacaca cccatacatg aaagcgatga 10680
gaaataggat tctcatcttg ccaaaatatc actagaaaaa atttatttat caattttaaa 10740
ggtataaaaa atacttattg ttgctcgaat attttgtatt tgatggtata cggaagatta 10800
gaaatgtagg tattatcatc aactgattct atggttttat gtattctatc atgtttcact 10860
attgcgtcgg aaataatatc atatgcttcc acatatattt tattttgttt taactcataa 10920
tactcacgta attctggatt attggcatat ctatgaataa ttttagctcc atgatcagta 10980
aatattaatg agaacatagt attaccacct accattattt ttttcatttc gttcaattct 11040
tgattgcaaa gatctatata atcattatag cgttgactta tggactctgg aatcttagac 11100
gatgtacagt catctataat catggcatat ttaatacatt gttttatagc atagtagtta 11160
tctacgatgt tagatatttc tctcaatgaa tcaatcacac aatctaatgt aggtttatga 11220
cataatagca ttttcagcag ttcaatgttt ctagattcgt tgatggcaat ggctatacat 11280
gtatatccgt tatttgatct aatgttgaca tctgaaccgg attctagcag taaagatact 11340
agagattgtt tattatatct aacagccttg tgaagaagtg tttctcctcg tttgtcaatc 11400
atgttaatgt ctttaagata aggtaggcaa atgtttatag tactaagaat tgggcaagca 11460
taagacatgt cacaaagacc ctttttgtat gtataagtgt aaaaattata acattcatag 11520
ttggatttac ataggtgtcc aatcgggatc tctccatcat cgagataatt gatggcatct 11580
cccttccttt tttagtagat atttcatcgt gtaagaatca atattaatat ttctaaagta 11640
ttcgtgtata gcctctttat ttaccacagt tccatattcc actagaggga tatcgccgaa 11700
tgtcatatac tcaattagta tatgttggag gacatccgag ttcattgttt tcaatatcaa 11760
aaagatggtt tccttatcat ttctccatag tggtacaata ctacacatta ttccgtgcgg 11820
ctttccattt tccaaaaaca atttgaccaa atctaaatct acatctttat tgtatctata 11880
atcactattt agataatcag ccataattac tcgagtgcaa catgttagat cgtctatata 11940
tgaataagca gtgttatcta ttcctttcat taacaattta acgatgtcta tatctatatg 12000
agatgactta atataatatt gaagagctgt acaatagttt ttatctatag aagacggctt 12060
gattccgtga ttaattagac atttaacaac ttccggacgc acatatgctc tcgtatccga 12120
ctttgaatac agatgagaga tgatatacag atgcaatacg gtaccgcaat ttcgtagttg 12180
ataatcatca tacgcgtatc agtactcgtc ctcataaaga acactgcagc cattttctat 12240
gaacaaatca ataattttag gaacaggatc attgtcatta cataattttc tataactgaa 12300
cgatggtttt cacatttaac actcaagtca aatccatgtt ctaccaacac ctttatcaag 12360
tcaacgtcta catttttgga tttcatatag ctgaatatat taaagtcatt tatgttgcta 12420
aatccagtgg cttctagtag agccatcgct atatccttta actttaacat gtctactatt 12480
tgtgtattct tctaatgggg tagctgtctc caatttttgc gtaatggatt agtgccactg 12540
tctagtagta gtttgacgac ctcgacatta ttacaatgct cattaaaaag gtatgcgtgt 12600
aaagcattat tcttgaattg gttcctggta tcattaggat ctctgtctct caacatctgt 12660
ttaagttcat cgagagccac ctcctcattt tccagatagt caaacatttt gactgaatga 12720
gctactgtga actctataca cccacacaac taatgtcatt aaatattatt tttttgaatg 12780
tatttatacc atgtcaaaaa cttgtacaat tattaataaa aataatttag tgtttaaatt 12840
ttaccagttc cagattttac acctccgtta accccacttt ttacaccact ggacgatcct 12900
cctccccaca ttccaccgcc accagatgta taagttttag atcctttatt actaccatca 12960
tgtccatgga taaagacact ccacatgccg ccactactac cccctttaga agacatatta 13020
ataagactta aggacaagtt taacaataaa attaatcacg agtaccctac taccaaccta 13080
cactattata tgattatagt ttctattttt acagtacctt aactaaagtc tctagtcaca 13140
agagcaatac taccaaccta cactattata tgattatagt ttctattttt ataggaacgc 13200
gtacgagaaa atcaaatgtc taatttctaa cggtagtgtt gataaacgat tatcgtcaat 13260
ggatacctcc tctatcatgt cgtctatttt cttactttgt tctattaact tattagcatt 13320
atatattatt tgattataaa acttatattg cttattagcc caatctgtaa atatcggatt 13380
attaacatat cgtttctttg taggtttatt taacatgtac atcactgtaa gcatgtccgt 13440
accatttatt ttaatttgac gcatatccgc aatttctttt tcgcagtcgg ttataaattc 13500
tatatatgat ggatacatgc tacatgtgta cttataatcg actaatatga agtacttgat 13560
acatattttc agtaacgatt tattattacc acctatgaat aagtacctgt gatcgtctag 13620
gtaatcaact gttttcttaa tacattcgat ggttggtaat ttactcagaa taatttccaa 13680
tatcttaata tataattctg ctatttctgg gatatattta tctgccagta taacacaaat 13740
agtaatacat gtaaacccat attttgttat tatattaatg tctgcgccat tatctattaa 13800
ccattctact aggctgacac tatgcgactt aatacaatga taaagtatac tacatccatg 13860
tttatctatt ttgtttatat catcaatata cggcttacaa agttttagta tcgataacac 13920
atccaactca cgcatagaga aggtagggaa taatggcata atatttatta ggttatcatc 13980
attgtcatta tctacaacta agtttccatt ttttaaaata tactcgacaa ctttaggatc 14040
tctattgcca aatttttgaa aatatttatt tatatgctta aatctatata atgtagctcc 14100
ttcatcaatc atacatttaa taacattgat gtatactgta tgataagata catattctaa 14160
caatagatct tgtatagaat ctgtatatct tttaagaatt gtggatatta ggatattatt 14220
acgtaaacta ttacacaatt ctaaaatata aaacgtatca cggtcgaata atagttgatc 14280
aactatataa ttatcgattt tgtgattttt cttcctaaac tgtttacgta aatagttaga 14340
tagaatattc attagttcat gaccactata gttactatcg aataacgcgt caaatatttc 14400
ccgtttaata tcgcatttgt caagataata atagagtgtg gtatgttcac gataagtata 14460
ataacgcatc tcttttttgt gtgaaattaa atagtttatc acgtccaaag atgtagcata 14520
accatcttgt gacctagtaa taatataata atagagaact gttttaccca ttctatcatc 14580
ataatcagtg gtgtagtcgt aatcgtaatc gtctaattca tcatcccaat tataatattc 14640
accagcacgt ctaatctgtt ctattttgat cttgtatcca tactgtatgt tgctacatgt 14700
aggtattcct ttatccaata atagtttaaa cacatctaca ttgggatttg atgttgtagc 14760
gtatttctct acaatattaa taccattttt gatactattt atttctatac ctttcgaaat 14820
tagtaatttc aataagtcta tatcgatgtt atcagaacat agatattcga atatatcaaa 14880
atcattgata tttttatagt cgactgacga caataacaaa atcacaacat cgtttttgat 14940
attattattt ttcttggtaa cgtatgcctt taatggagtt tcaccatcat actcatataa 15000
tggatttgca ccactttcta tcaatgattg tgcactgctg gcatcgatgt taaatgtttt 15060
acaactatca tagagtatct tatcgttaac catgattggt tgttgatgct atcgcatttt 15120
ttggtttctt tcatttcagt tatgtatgga tttagcacgt ttgggaagca tgagctcata 15180
tgatttcagt actgtagtgt cagtactatt agtttcgatc agatcaatgt ctagatctat 15240
agaatcaaaa cacgataggt cagaagataa tgaatatctg tacgcttctt tttgtactgt 15300
aacttctggt tttgttagat ggttgcatcg tgctttaaca tcaatggtac aaattttatc 15360
ctcgctttgt gtatcatatt cgtctctagt ataaaattct atattcagat tatcatgcga 15420
tgtgtatacg ctaacggtat caataaacgg agcacaccat ttagtcataa cagtaatcca 15480
aaatttttta aagtatatct taacgaaaga agttgtgtca ttgtctacgg tgtatggtac 15540
tagatcctca taagtgtata tatctagagt aatgtttaat ttattaaatg gttgataata 15600
tggatcctca tgacaatttc cgaagatgga aatgagatat agacatgcaa taaatctaat 15660
cgaagacatg gttactcctt aaaaaaatac gaataatcac cttggctatt tagtaagtgt 15720
catttaacac tatactcata ttaatccatg gactcataat ctctatacgg gattaacgga 15780
tgttctatat acggggatga gtagttttct tctttaactt tatacttttt actaatcata 15840
tttagactga tgtatgggta atagtgttta aagagttcgt tctcatcatc agaataaatc 15900
aatatctctg tttttttgtt atacagatgt attacagcct catatattac gtaatagaac 15960
gtgtcatcta ccttattaac tttcaccgca tagttgtttg caaatacggt taatcctttg 16020
acctcgtcga tttccgacca atctgggcgt ataatgaatc taaactttaa tttcttgtaa 16080
tcattcgaaa taatttttag tttgcatccg tagttatccc ctttatgtaa ctgtaaattt 16140
ctcaacgcga tatctccatt aataatgatg tcgaattcgt gctgtatacc catactgaat 16200
ggatgaacta acgaatatca acggcgttaa tagtaattta ctttttcatc tttacatatt 16260
gggtactagt tttactatca taagtttata aattccacaa gctactatgg aataagccaa 16320
ccatcttagt ataccacaca tgtcttaaag tttattaatt aattacatgt tgttttatat 16380
atatcgctac gaatttaaag agaaatcagt ttaggaagaa aaaaattatc tatctacatc 16440
atcacgtctc tgtattctac gatagagtgc tactttaaga tgagacatat ccgtgtcatc 16500
aaaaatatac tccattaaaa tgattattcc ggcagcgaac ttgatattgg atatatcaca 16560
acctttgtta atatctacga caatagacag cagtcccatg gttccataaa cagtgagttt 16620
atctttcttt gaagcgatag tttgtagaga tcttataaaa ccgtcaaacg acatcgcatt 16680
tatatcttta gctaattcat atatgttacc atcgtaatat ctaaccgcgt ctatcttaaa 16740
cgtttccatc gctttaaaga cgtttccgat agatggtctc atttcatcag tcatactgag 16800
ccaacaaata taatcgtgta taacatcttt gatagaatca gactctaaag aaaacgaatc 16860
ggctttatta tacgcattca tgataaactt aatgaaaaat gtttttcgtt gtttaagttg 16920
gatgaatagt atgtcttaat aattgttatt atttcattaa ttaatattta gtaacgagta 16980
cactctataa aaacgagaat gacataacta gttatcaaag tgtctaggac gcgtaatttt 17040
catatggtat agatcctgta agcattgtct gtattctgga gctattttct ttatcgcatt 17100
agtaagttca gaatatgtta taaatttaaa tcgaataacg aacatgactt tagtaaagtc 17160
gtctatatta actcttttat tttctagcca tcgtaatacc atgtttaaga tagtatattc 17220
tctagttact acgatctcat cgttgtctag aatatcacat actgaatcta catccaattt 17280
tagaaattgg tctgtgttac atatctcttc tatattattg ttgatgtatt gtcgtagaaa 17340
actattacgt agaccatttt ctttataaaa cgaatatata gtactccaat tatctttacc 17400
gatatatttg cacacataat ccattctctc aatcactaca tctttaagat tttcgttgtt 17460
aagatatttg gctaaactat ataattctat tagatcatca acagaatcag tatatatttt 17520
tctagatcca aagacgaact ctttggcgtc ctctataata ttcccagaaa agatattttc 17580
gtgttttagt ttatcgagat ctgatctgtt catatacgcc atgattgtac ggtacgttat 17640
gataaccgca taaaataaaa atccattttc atttttaacc aatactattc ataattgaga 17700
ttgatgtaat actttgttac tttgaacgta aagacagtac acggatccgt atctccaaca 17760
agcacgtagt aatcaaattt ggtgttgtta aacttcgcaa tattcatcaa tttagataga 17820
aacttatact catcatctgt tttaggaatc catgtattat taccactttc caacttatca 17880
ttatcccagg ctatgtttcg tccatcatcg ttgcgcagag tgaataattc ttttgtattc 17940
ggtagttcaa atatatgatc catgcataga tcggcaaagc tattgtagat gtgatttttc 18000
ctaaatctaa tataaaactc gtttactagc aaacactttc ctgatttatc gaccaagaca 18060
catatggttt ctaaatctat caagtggtgg ggatccatag ttatgacgca gtaacataga 18120
ttattacatt cttgactgtc gctaatatct aaatatttat tgttatcgta ttggattctg 18180
catatagatg gcttgtatgt caaagatata gaacacataa ccaatttata gtcgcgcttt 18240
acattctcga atctaaagtt aagagattta gaaaacatta tatcctcgga tgatgttatc 18300
actgtttctg gagtaggata tattaaagtc tttacagatt tcgtccgatt caaataaatc 18360
actaaataat atcccacatt atcatctgtt agagtagtat cattaaatct attatatttt 18420
atgaaagata tatcactgct cacctctata tttcgtacat ttttaaactg tttgtataat 18480
atctctctga tacaatcaga tatatctatt gtgtcggtag acgataccgt tacatttgaa 18540
ttaatggtgt tccattttac aacttttaac aagttgacca attcatttct aatagtatca 18600
aactctccat gattaaatat tttaatagta tccattttat atcactacgg acacaaagta 18660
gctgacataa accattgtat aatttttatg ttttatgttt attagcgtac acattttgga 18720
agttccggct tccatgtatt tcctggagag caagtagatg atgaggaacc agatagttta 18780
tatccgtact tgcacttaaa gtctacattg tcgttgtatg agtatgatct tttaaacccg 18840
ctagacaagt atccgtttga tattgtagga tgtggacatt taacaatctg acacgtgggt 18900
ggatcggacc attctcctcc tgaacacagg acaccagagt taccaatcaa cgaatatcca 18960
ctattgcaac tataagttac aacgctccca tcggtataaa aatcctcgta tccgttatgt 19020
cttccgttgg atatagatgg aggggattgg catttaacag attcacaaat aggtgcctcg 19080
ggattccata ccatagatcc agtagatcct aattcacaat acgatttaga ttcaccgatc 19140
aaatgatatc cgctattaca agagtacgtt atactagagc caaagtctac tccaccaata 19200
tcaagttggc cattatcgat atctcgaggc gatgggcatc tccgtttaat acattgatta 19260
aagagtgtcc atccagtacc tgtacattta gcatatatag gtcccatttt ttgctttctg 19320
tatccaggta gacatagata ttctatagtg tctcctatgt tgtaattagc attagcatca 19380
gtctccacac tattcttaaa tttcatatta atgggtcgtg acggaatagt acagcatgat 19440
agaacgcatc ctattcccaa caatgtcagg aacgtcacgc tctccacctt catatttatt 19500
tatccgtaaa aatgttatcc tggacatcgt acaaataata aaaagcccat atatgttcgc 19560
tattgtagaa attgtttttc acagttgctc aaaaacgatg gcagtgactt atgagttacg 19620
ttacactttg gagtctcatc tttagtaaac atatcataat attcgatatt acgagttgac 19680
atatcgaaca aattccaagt atttgatttt ggataatatt cgtattttgc atctgctata 19740
attaagatat aatcaccgca agaacacacg aacatctttc ctacatggtt aaagtacatg 19800
tataattcta tccatttgtc ttccttaact atatatttgt atagataatt acgagtctcg 19860
tgagtaattc cagtaattac atagatgtcg ccgtcgtact ctacagcata aactatacta 19920
tgatgtctag gcatgggaga cttttttatc caacgatttt tagtgaaaca ttccacatcg 19980
tttaatacta catatttttc atacgtggta taaactccac ccattacata tatatcatcg 20040
tttacgaata ccgacgcgcc tgaatatcta ggagtaatta agtttggaag tcttatccat 20100
ttcgaagtgc cgtgtttcaa atattctgcc acacccgttg aaatagaaaa ttctaatcct 20160
cctattacat ataactttcc atcgttaaca caagtactaa cttctgattt taacgacgac 20220
atattagtaa ccgttttcca ttttttcgtt tcaagatcta cccgcgatac ggaataaaca 20280
tgtctattgt taatcatgcc gccaataatg tatagacaat tatgtaaaac atttgcatta 20340
tagaattgtc tatctgtatt accgactatc gtccaatatt ctgttctagg agagtaatgg 20400
gttattgtgg atatataatc agagttttta atgactacta tattatgttt tataccattt 20460
cgtgtcactg gctttgtaga tttggatata gttaatccca acaatgatat agcattgcgc 20520
atagtattag tcataaactt gggatgtaaa atgttgatga tatctacatc gtttggattt 20580
ttatgtatcc actttaataa tatcatagct gtaacatcct catgatttac gttaacgttt 20640
tcgtgggata agatagttgt cagttcatcc tttgataatt ttccaaattc tggatcggat 20700
gtcaccgcag taatattgtt gattatttct gacatcgacg cattatatag ttttttaatt 20760
ccatatcttt tagaaaagtt aaacatcctt atacaatttg tggaattaat attatgaatc 20820
atagttttta cacatagatc tactacaggc ggaacatcaa ttattatggc agcaactagt 20880
atcatttcta cattgtttat ggtgatgttt atcttcttcc agcgtatata gtctaatagc 20940
gattcaaacg cgtgatagtt tataccattc aatataatcg cttcatcctt tagatggtga 21000
tcctgaattc gtttaaaaaa attatacgga gatgccgtaa taatttcctt attcacttgt 21060
ataatttccc cattgataga aaatatcacg ctttccattc ttgaagtact ataagtaatt 21120
atagtataat gtaaaggttt atatattcaa tattttttat aaaaaaatca ttttgacatt 21180
aattcctttt taaatttccg tctatcatct atagaaacgt attctatgaa tttataaaat 21240
gcttttacgt gtcctatcgt aggcgataga accgctaaaa agcctatcga atttctacaa 21300
aagaatctgt tatatggtat agggagagta taaaacatta aatgtccgta cttattaaag 21360
tattcagtag ccaatcctaa ctctttcgaa tacttattaa tggctcttgt tctgtacgaa 21420
tctatttttt tgaacaacgg acctagtggt atatcttgtt ctatgtatct aaaataatgt 21480
ctgactagat ccgttagttt aatatcctca gtcatcttgt ctagaatggc aaatctaact 21540
gcgggtttag gctttagttt agtttttata tctacatcta tgtctttatc taacaccaaa 21600
aatataatag ctaatatttt attacaatca tccggatatt cttctacgat ctcactaact 21660
aatgtttctt tggttatact agtatagtca ctatcggaca aataaagaaa atcagatgat 21720
cgatgaataa tacatttaaa ttcatcatct gtaagatttt tgagatgtct cattaaaata 21780
ttattagggt cagtactcat tatcattcgg cagctattac ttattttatt tttctgtatt 21840
ttattatttt tcaccatata gatcaatcat tagatcatca aaatatgttt caatcatcct 21900
aaagagtatg gtgaatgact cttcccatct aatttctgaa cgttcaccaa tgtctctagc 21960
cactttggca ctaatagcga tcattcgctt agcgtcttct atattattaa ctggttgatt 22020
caatctatct agcaatggac cgtcggacag cgtcattctc atgttcttaa tcaatgtaca 22080
tacatcgccg tcatctacca attcatccaa caacataagc tttttaaaat catcattata 22140
ataggtttga tcgttgtcat ttctccaaag aatatatcta ataagtagag tcctcatgct 22200
tagtaattta actattttag ttaacaacta ttttttatgt taaatcaatt agtacaccgc 22260
tatgtttaat acttattcat attttagttt ttaggattga gaatcaatac aaaaaattaa 22320
tgcatcatta attttagaaa tacttagttt ccacgtagtt aatgaaacat ttgaactcat 22380
cgtacaggac gttctcgtac aggacgtaac tataaaccgg tttatatttg ttcaagatag 22440
atacaaatcc gataactttt tttacgaatt ctacgggatc cactttaaaa gtgtcatacc 22500
gggttctttt tattctttta aacagatcaa tggtgtgatg ttgattaggt cttttacgaa 22560
tttgatatag aatagcgttc acatatcctc cataatggtc aatcgccatt tgttcgtatg 22620
tcataaattc tttaattata tgacactgtg tattatttag ttcatccttg ttcatcatta 22680
ggaatctatc caaaatggca attatactag aactataggt gcgttgtata cacatattga 22740
tgtgtctgtt tatacaatcc atgatatttg gatccatgct actaccttcg ggtaaaattg 22800
tagcatcata taccatttct agtactttag gttcattatt atccattgca gaggacgtca 22860
tgatcgaatc ctaaaaaaat atattatttt tatgttattt tgttaaaaat aatcatcgaa 22920
tacttcgtaa gatactcctt catgaacata atcagttaca aaacgtttat atgaagtaaa 22980
gtatctacga tttttacaaa agtccggatg cataagtaca aagtacgcga taaacggaat 23040
aataatagat ttatctagtc tatctttttc tatagctttc atagttagat acatggtctc 23100
agaagtagga ttatgtaaca tcagcttcga taaaatgact gggttattta gtcttacaca 23160
ttcgctcata catgtatgac cgttaactac aaagtctaca ctaaaatgat tgaacaatag 23220
atagtctacc attgtttcgt attcagatag tacagcgtag tacatagcat cttcacaaat 23280
tatatcattg tctaatagat atttgacgca tcttatggat cccacttcaa cagccatctt 23340
aaaatcggta gaatcatatt gctttccttt atcattaata atttctaaaa catcatctct 23400
atcataaaag atacaaatat taactgtttg atccgtaata acattgctag tcgatagcaa 23460
tttgttaata agatgcgctg ggctcaatgt cttaataaga agtgtaagag gactatctcc 23520
gaatttgttt tgtttattaa catccgttga tggaagtaaa agatctataa tgtctacatt 23580
cttgactgtt ttagagcata caatatggag aggtgtattt ccatcatgat ctggttttga 23640
gggactaatt cctagtttca tcatccatga gattgtagaa gcttttggat tgtctgacat 23700
aagatgtcta tgaatatgat ttttgccaaa tttatccact atcctggctt cgaatccgat 23760
ggacattatt tttttaaaca ctctttctga aggatctgta cacgccaaca acggaccaca 23820
tccttcttca tcaaccgagt tgttaatctt ggctccatac tgtaccaata aatttattct 23880
ctctatgact tcatcatctg ttcccgagag ataatataga ggtgttttat tatgtttatc 23940
acacgcgttt ggatctgcgc cgtgcgtcag cagcatcgcg actattctat tattattaat 24000
tttagaagct atatgcaatg gataatttcc atcatcatcc gtctcatttg gagagtatcc 24060
tctatgaaga agttcttcga caaatcgttc atctagtcct ttaattccac aatacgcatg 24120
tagaatgtga taattatttc cagaaggttc gatagcttgt agcatattcc taaatacatc 24180
taaattttta ctattatatt tggcataaag agatagataa tactcggccg acataatgtt 24240
gtccattgta gtataaaaat taatatttct atttctattt ctgtatattt gcaacaattt 24300
actctctata acaaatatca taacttagtt cttttatgtc aagaaggcac tggtttagtt 24360
catctataaa tgtcacgcca taactaccac gcatgctata ctcagaatta tgataaagat 24420
atttatcctt ggggtgtagg taatggggat taatctttgt tggatcagtc tctaagttaa 24480
cacatgtcac acatgatcca tttatagtta tatcacacga tgatgattta tgaattgatt 24540
ccggaagatc gctatcgtat tttgtggttc cacaattcat ttccatacat gttattgtca 24600
cactaatatt atgatgaact ttatctagcc gctgagtggt aaacaacaga acagatagtt 24660
tattatcttt accaacaccc tcagccgctg ccacaaatct ctgatccgta tccatgatgg 24720
tcatgtttat ttctagtccg tatccagtca acactatgtt agcatttctg tcgatatagc 24780
tttcactcat atgacactca ccaataatag tagaattaat gtcgtaattt acaccaatag 24840
tgagttcggc ggcaaagtac caataccggt aatcttgtcg aggaggacat atagtattct 24900
tgtattctac cgaatacccg agagatgcga tacaaaagag taagactaat ttgtaaacca 24960
tcttactcaa aatatgtaac aatagtacga tgcaatgagt aagacaatag gaaatctatc 25020
ttatatacac ataattattc tatcaatttt accaattagt tagtgtaatg ttaacaaaaa 25080
tgtgggagaa tctaattagt ttttctttac acaattgacg tacatgagtc tgagttcctt 25140
gtttttgcta attatttcat ccaatttatt attcttgact atatcgagat cttttgtata 25200
ggagtcagac ttgtattcaa catgcttttc tataatcatt ttagctattt cggcatcatc 25260
caatagtaca ttttccagat tagcagaata gatattaatg tcgtatttga acagagcctg 25320
taacatctca atgtctttat tatctatagc caatttaatg tccggaatga agagaaggga 25380
attattggtg tttgtcgacg tcatatagtc gagcaagaga atcatcatat ccacgtgtcc 25440
attttttata gtgatgtgaa tacaactaag gagaatagcc agatcaaaag tagatggtat 25500
ctctgaaaga aagtaggaaa caatacttac atcattaagc atgacggcat gataaaatga 25560
agttttccat ccagttttcc catagaacat cagtctccaa tttttcttaa caaacagttt 25620
taccgtttgc atgttaccac tatcaaccgc ataatacaat gcggtgtttc ccttgtcatc 25680
aaattgtgaa tcatccagtc cactgaatag caaaatcttt actattttgg tatcttccaa 25740
tgtggctgcc tgatgtaatg gaaattcatt ctctagaaga tttttcaatg ctccagcgtt 25800
caacaacgta catactagac gcacgttatt atcagctatt gcataataca aggcactatg 25860
tccatggaca tccgccttaa atgcatcttt gctagagaga aagcttttca gctgcttaga 25920
cttccaagta ttaattcgtg acagatccat gtctgaaacg agacgctaat tagtgtatat 25980
tttttcattt tttataattt tgtcatattg caccagaatt aataatatct ctaatagatc 26040
tgattagtag atacatggct atcgcaaaac aacatataca catttaataa aaataatatt 26100
tattaagaaa attcagattt cacgtaccca tcaatataaa taaaataatg attccttaca 26160
ccgtacccat attaaggaga ttccacctta cccataaaca atataaatcc agtaatatca 26220
tgtctgatga tgaacacaaa tggtgtatta aattccagtt tttcaggaga tgatctcgcc 26280
gtagctacca taatagtaga tgcctctgct acagttcctt gttcgtcgac atctatcttt 26340
gcattctgaa acattttata aatatataat gggtccctag tcatatgttt aaacgacgca 26400
ttatctggat taaacatact aggagccatc atttcggcta tcgacttaat atccctctta 26460
ttttcgatag aaaatttagg gagtttaaga ttgtacactt tattccctaa ttgaaacgac 26520
caatagtcta attttgcagc cgtaatagaa tctgtgaaat gggtcatatt atcacctatt 26580
gccaggtaca tactaatatt agcatcctta tacggaaggc gtaccatatc atattcttcg 26640
tcatcgattg tgattgtatt tccttgcaat ttagtaacta cgttcatcat gggaaccgtt 26700
ttcgtaccgt acttattagt aaaactagca ttgcgtgttt tagtgatatc aaacggatat 26760
tgccatatac ctttaaaata tatagtatta atgattgccc atagagtatt attgtcgagc 26820
atattagaat ctactacatt agacataccg gatctacgtt ctactataga attaatttta 26880
ttaaccgcat ctcgtctaaa gtttaatcta tataggccga atctatgata ttgttgataa 26940
tacgacggtt taatgcacac agtattatct acgaaacttt gataagttag atcagtgtac 27000
gtatatttag atgttttcag cttagctaat cctgatatta attctgtaaa tgctggaccc 27060
agatctcttt ttctcaaatc catagtcttc aataattcta ttctagtatt acctgatgca 27120
ggcaatagcg acataaacat agaaaacgaa taaccaaacg gtgagaagac aatattatca 27180
tcttgaatat ttttatacgc tactataccg gcattggtaa atccttgcag acgataggta 27240
gacactgaac acgttaacga tagtatcaat aacgcaatca tgattttatg gtattaataa 27300
ttaaccttat ttttatgttc ggtataaaaa ttattgatgt ctacacatcc ttttgtaatt 27360
gacatctata tatccttttg tataatcaac tctaatcact ttaactttta cagttttccc 27420
taccagttta tccctatatt caacatatct atccatatgc atcttaacac tctctgccaa 27480
gatagcttca aagtgaggat agtcaaaaag ataaatatat agagcataat ccttctcgta 27540
tactctgccc tttattacat cacccgcatt gggcaacgaa taacaaaatg caagcatctt 27600
gttaacgggc tcgtaaattg ggataaaaat tatgttttta tatctatttt attcaagaga 27660
atattcagga atttcttttt ccggttgtat ctcatcgcag tatatatcat ttgtacattg 27720
tttcatattt tttaatagtc tacacctttt agtaggacta gtatcgtaca attcatagct 27780
gtattttgaa ttccaatcac gcataaaaat atcttccaat tgttgacgaa gacctaatcc 27840
atcatccggt gtaatattaa tagatgctcc acatgtatcc gtaaagtaat ttcctgtcca 27900
atttgaggta cctatatacg ccgttttatc ggttaccata tatttggcat ggtttaccct 27960
agaatacgga atgggaggat cagcatctgg tacaataaat agctttactt ctatatttat 28020
gtttttagat tttagcatag cgatagatct taaaaagttt ctcatgataa acgaagatcg 28080
ttgccagcaa ctaatcaata gcttaactga cacttgtctg tctatagcgg ctcttcttaa 28140
ttcatcttct atataaggcc aaaacaaaat attgcctgcc ttcgaataaa taatagggat 28200
aaagttcata acagatacat aaacgaattt actcgcattt ctgatacatg acaataaagc 28260
ggttaaatca ttggttcttt ccatagtaca tagttgttgc ggtgcagaag caataaatac 28320
agagtgtgga acgccgctta cgttaatact aagaggatga tctgtattat aatacgacgg 28380
ataaaagttt ttccaattat atggtagatt gttaactcca agataccagt atacctcaaa 28440
aatttgagtg agatccgctg ccaagttcct attattgaag atcgcaatac ccaattcttt 28500
gacctgagtt agtgatctcc aatccatgtt agcgcttcct aaataaatat gtgtattatc 28560
agatatccaa aattttgtat gaagaactcc tcctaggata tttgtaatat ctatgtatcg 28620
tacttcaact ccggccattt gtagtctttc aacatccttt aatggtttgt tagatttatt 28680
gacggctact ctaactcgta ctcctctttt gggtaattgt acaatcttgt ttaatattat 28740
cgtgccgaaa ttcgtaccca cttcatccga taaactccaa taaaaagatg atatatctag 28800
tgtttttgtg gtattggata gaatttccct ccacatgtta aatgtagaca aatatacttt 28860
atcaaattgc atacctatag gaatagtctc tgtaatcact gcgattgtat tatccggatt 28920
cattttattt gttaaaagaa taatcctata tcacttcact ctattaaaaa tccaagtttc 28980
tatttctttc atgactgatt ttttaacttc atccgtttcc ttatgaagat gatgtttggc 29040
accttcataa atttttattt ctctattaca atttgcatgt tgcatgaaat aatatgcacc 29100
taaaacatcg ctaatcttat tgtttgttcc ctggagtatg agagtcgggg ggtgttaatc 29160
ttggaaatta tttttctaac cttgttggta gccttcaaga cctgactagc aaatccagcc 29220
ttaatttttt catgattgat taatgggtcg tattggtatt tataaacttt atccatatct 29280
ctagatactg attctggaca tagctttccg actggcgcat ttagtgtgat ggttcccata 29340
agtttggcag ctagcagatt cagttttgaa acagcatctg cattaactag aggagacatt 29400
agaatcattg ctgtaaacaa gtttggatta tcgtaagagg ctagctccca tggaatgacc 29460
caataagtag atttaatagt taccacgtgc tgtaccaaag tcatcaatca tcattttttc 29520
accattactt cttccatgtc caatatgatc atgtgagaat actaaaattc ctaacgatga 29580
tatgttttca gctagttcgt cataacgtcc agaatgttta ccagctccat gacttatgaa 29640
tactaatgcc ttaggatatg taataggttt ccaatatatg taatcattgt ccagattgaa 29700
catacagttt gcactcatga ttcacgttat ataactatca atattaacag ttcgtttgat 29760
gatcatatta tttttatgtt ttattgataa ttgtaaaaac atacaattaa atcaatatag 29820
aggaaggaga cggctactgt cttttgtgag atagtcatgg cgactaaatt agattatgag 29880
gatgctgttt tttactttgt ggatgatgat aaaatatgta gtcgcgactc catcatcgat 29940
ctaatagatg aatatattac gtggagaaat catgttatag tgtttaacaa agatattacc 30000
agttgtggaa gactgtacaa ggaattgatg aagttcgatg atgtcgctat acggtactat 30060
ggtattgata aaattaatga gattgtcgaa gctatgagcg aaggagacca ctacatcaat 30120
tttacaaaag tccatgatca ggaaagttta ttcgctacca taggaatatg tgctaaaatc 30180
actgaacatt ggggatacaa aaagatttca gaatctagat tccaatcatt gggaaacatt 30240
acagatctga tgaccgacga taatataaac atcttgatac tttttctaga aaaaaaattg 30300
aattgatgat ataggggtct tcataacgca taattattac gttagcattc tatatccgtg 30360
ttaaaaaaaa ttatcctatc atgtatttga gagttttata tgtagcaaac atgatagctg 30420
tgatgccaat aagctttaga tattcacgcg tgctagtgtt agggatggta ttatctggtg 30480
gtgaaatgtc cgttatataa tctacaaaat aatcatcgca tatagtatgc gatagtagag 30540
taaacatttt tatcgtttct actgggttca tacatcgtct acccaattcg gttataaatg 30600
aaattgtcgc caatcttaca cccaacccct tgttatccat tagtatagta ttaacttcgt 30660
tatttatgtc ataaactgta aatgattttg tagatgccat atcatacatg atattcatgt 30720
ccctattata atcattacta actttatcac aatatatgtt gataatatct atatatgatc 30780
tagtctttgt gggcaactgt ctatacaagt cgtctaaacg ttgtttactc atatagtatc 30840
gaacagccat cattacatgg tcccgttccg ttgatagata atcgagtatg ttagtggact 30900
tgtcaaatct atataccata ttttctggaa gtggatatac atagtcgtga tcaacattat 30960
tgctagcctc atcttctata tcctgtacta taccattatc tatatcatct acataatcta 31020
cgatattatt acacataaac atcgacaaca tactattgtt tattatctaa gtcctgttga 31080
tccaaaccct tgatctcctc tatttgtact atctagagat tgtacttctt ccagttctgg 31140
ataatatata cgttgataga ttagctgagc tattctatct ccagtattta cattaaacgt 31200
acattttcca ttattaataa gaatgactcc tatgtttccc ctataatctt cgtctattac 31260
accgcctcct atatcaatgc cttttaggga cagaccagac ctaggagcta ttctaccata 31320
gcagaactta ggcatggaca tactaatatc tgtcttaatt aactgtcgtt ctcctggagg 31380
gatagtataa tcgtaagcgc tatataaatc atatccggcg gcgtaaggtg attgcctagt 31440
aggagattta gctctgttag tttccttaac aaatctaact ggtgagttaa tattcatgtt 31500
gaacataaaa ctaatatttt atttcaaaat tatttaccat cccatatatt ccatgaataa 31560
gtgtgatgat tgtacacttc tatagtatct atatacgatt cacgataaaa tcctcctatc 31620
aatagcagtt tattatccac tatgatcaat tctggattat ccctcggata aataggatca 31680
tctatcagag tccatgtatt gctggattca caataaaatt ccgcatttct accaaccaag 31740
aataaccttc taccgaacac taacgcgcat gatttataat gaggataata agtggatggt 31800
ccaaactgcc actgatcatg attgggtagc aaatattctg tagttgtatc agtttcagaa 31860
tgtcctccca ttacgtatat aacattgttt atggatgcca ctgctggatt acatctaggt 31920
ttcagaagac tcggcatatt aacccaagca gcatccccgt ggaaccaacg ctcaacagat 31980
gtgggatttg gtagacctcc tactacgtat aatttattgt tagcgggtat cccgctagca 32040
tacagtctgg ggctattcat cggaggaatt ggaatccaat tgtttgatat ataatttacc 32100
gctatagcat tgttatgtat ttcattgttc atccatccac cgatgagata tactacttct 32160
ccaacatgag tacttgtaca catatggaat atatctataa tttgatccat gttcatagga 32220
tactctatga atggatactt gtatgatttg cgtggttgtt tatcacaatg aaatattttg 32280
gtacagtcta gtatccattt tacattattt atacctctgg gagaaagata atttgacctg 32340
attacatttt tgataaggag tagcagattt cctaatttat ttcttcgctt tatataccac 32400
ttaatgacaa aatcaactac ataatcctca tctggaacat ttagttcatc gctttctaga 32460
ataagtttca tagatagata atcaaaattg tctatgatgt catcttccag ttccaaaaag 32520
tgtttggcaa taaagttttt agtatgacat aagagattgg atagtccgta ttctataccc 32580
atcatgtaac actcgacaca atattccttt ctaaaatctc gtaagataaa gtttatacaa 32640
gtgtagatga taaattctac agaggttaat atagaagcac gtaataaatt gacgacgtta 32700
tgactatcta tatatacctt tccagtatac gagtaaataa ctatagaagt taaactgtga 32760
atgtcaaggt ctagacaaac ccttgtaact ggatctttat ttttcgtgta tttttgacgt 32820
aaatgtgtgc gaaagtaagg agataacttt ttcaatatcg tagaattgac tattatattg 32880
ccacctatag catcaataat tgttttgaat ttcttagtca tagacaatgc taatatattc 32940
ttacagtaca cagtattaac aaatatcggc atttatgttt ctttaaaagt caacatctaa 33000
agaaaaatga ttatcttctt gagacataac tcccattttt tggtattcac ccacacgttt 33060
ttcgaaaaaa ttagtttttc cttccaatga tatattttcc atgaaatcaa acggattggt 33120
aacattataa atttttttaa atcccaattc agaaatcaat ctatccgcga cgaattctat 33180
atatgttttc atcatttcac aattcattcc tataagttta actggaagag ccgcagtaag 33240
aaattcttgt tcaatggata ccgcatctgt tataatagat ctaacggttt cttcactcgg 33300
tggatgcaat aaatgtttaa acatcaaaca tgcgaaatcg cagtgcagac cctcgtctct 33360
actaattagt tcgttggaaa acgtgagtcc gggcattagg ccacgctttt taagccaaaa 33420
tatggaagcg aatgatccag aaaagaagat tccttctact gcagcaaagg caataagtct 33480
ctctccataa ccggcgctgt catgtatcca cttttgagcc caatcggcct tcttttttac 33540
acaaggcatc gtttctatgg cattaaagag atagtttttt tcattactat ctttaacata 33600
agtatcgatc aaaagactat acatttccga atgaatgttt tcaatggcca tctgaaatcc 33660
gtagaaacat ctagcctcgg taatctgtac ttctgtacaa aatcgttccg ccaaattttc 33720
attcactatt ccgtcactgg ctgcaaaaaa cgccaataca tgttttataa aatatttttc 33780
gtctggtgtt agtttattcc aatcattgat atctttagat atatctactt cttccactgt 33840
ccaaaatgat gcctctgcct ttttatacat gttccagatg tcataatatt ggattgggaa 33900
aataacaaat ctatttggat ttggtgcaag gatgggttcc ataactaaat taacaataac 33960
aataaatttt ttttcagtta tctatatgcc tgtacttgga tcttttgtac atcgatatcg 34020
ccgcaatcac tacaataatt acaagtatta ttgatagcat tgttattagt actatcataa 34080
ttaaattatc gacattcatg ggtgctgaat aatcgttatt atcatcatta tcattttgta 34140
attgtgacat catactagat aaatcgtttg cgagattgtt gtgggaagcg ggcatggagg 34200
atgaattatc gttattatta tttaacgcct cccattcgga ttcacaaatg ttacgcacat 34260
tcaacatttt atggaaacta taattttgtg aaaacagata acaagaaaac tcgtcatcgt 34320
tcaaattttt aacgatagta aaccgattaa acgtcgagct aatttctaac gctagcgact 34380
ctgttggata tgggtttcca gatatatatc ttttcagttc ccctacgtat ctataatcat 34440
ctgtaggaaa tggaagatat ttccatttat ctactgttcc taatatcata tgtggtggtg 34500
tagtagaacc attaagcgcg aaagatgtta tttcgcatcg tattttaact tcgcaataat 34560
ttctggttag ataacgcact ctaccagtca agtcaatgat attagccttt acagatatat 34620
tcatagtagt tgtaacgatg actccatctt ttagatgcga tactcctttg tatgtaccag 34680
aatcttcgta ccgcaaactc gatatattta aacaagttaa tgagatatta acgcgtttta 34740
tgaatgatga tatataacca gaagttttat cctcggtggc tagcgctata accttatcat 34800
tataatacca actagtgtga ttaatatgtg acacgttagt gtgggtacaa atatgtacat 34860
tatcgtctac gtcgtattcg atacatccgc atacagccaa caaatataaa atgacaaata 34920
ctctaacgcc gttcgtaccc atcttgatgc ggtttaataa atgttttgat ttcaatttat 34980
tgtaaaaaaa gattcggttt tatactgttc gatattctca ttgcttatat tttcatctat 35040
catctccaca cagtcaaatc cgtggttagc atgcacctca tcaaccggta aaagactatc 35100
ggactcttct atcattataa ctctagaata tttaatttgg tcattattaa tcaagtcaat 35160
tatcttattt ttaacaaacg tgagtatttt actcattttt tataaaaact tttagaaata 35220
tacagactct atcgtgtgtc tatatcttct ttttatatcc aatgtattta tgtctgattt 35280
ttcttcattt atcatatata atggtccaaa ttctacacgt gcttcggatt catccagatc 35340
attaaggttc ttataattgt aacatccttc tcttccctct tctacatctt ccttcttatt 35400
cttattctta gcgtcacaga atctaccaca gcaggatccc atgacgagcg tcatattaaa 35460
ctaatccatt ttcaattata atatacgatt agtaatgacc attaaaataa aaaatattct 35520
tcataaccgg caagaaagtg aaaagttcac attgaaacta tgtcagtagt atacatcatg 35580
aaatgatgat atatatatac tctattttgg tggaggatta tatgatataa ttcgtggata 35640
atcattctta agacacattt cttcattcgt aaatcttttc acgttaaatg agtgtccata 35700
ttttgcaatt tcttcatatg atggcggtgt acgtggacga agctgctcct gttcttgttg 35760
tagtcgccga ctgtcgtgtt tgcgtttaga tccctccatt atcgcgattg cgtagatgga 35820
gtactattat ataccttgta attaaatttt tttattaatt aaacgtataa aaacgttccg 35880
tatctgtatt taagagccag atttcgtcta atagaacaaa tagctacagt aaaaataact 35940
agaataattg ctacacccac tagaaaccac ggatcgtaat acggcaatcg gttttcgata 36000
ataggtggaa cgtatatttt atttaaggac ttaacaattg tctgtaaacc acaatttgct 36060
tccgcggatc ctgtattaac tatctgtaaa agcatatgtt gaccgggcgg agccgaacat 36120
tctccgatat ctaatttctg tatatctata atattattaa cctccgcata cgcattacag 36180
ttcttttcta gcttggatac cgcactaggt acatcgtcta gatctattcc tatttcttca 36240
gcgatagctc ttctatcctt ttccggaagc aatgaaatca cttcaataaa tgattcaacc 36300
atgagtgtga aactaagtcg agaattactc atgcatttgt tagttattcg gagcgcgcaa 36360
tttttaaact gtcctataac ctctcctata tgaatagcac aagtgacatt agtagggata 36420
gaatgttgag ctaatttttg taaataacta tctataaaaa gattatacaa agttttaaac 36480
tctttagttt ccgccattta tccagtctga gaaaatgtct ctcataataa atttttccaa 36540
gaaactaatt gggtgaagaa tggaaacctt taatctatat ttatcacagt ctgttttggt 36600
acacatgatg aattcttcta atgctgtact aaattcgata tctttttcga tttctggata 36660
tgtttttaat aaagtatgaa caaagaaatg gaaatcgtaa taccagttat gttcaacttt 36720
gaaattgttt tttattttct tgttaatgat tccagccact tgggaaaagt caaagtcgtt 36780
taatgccgat ttaatacgtt cattaaaaac aaacttttta tcctttagat gaattattat 36840
tggttcattg gaatcaaaaa gtaagatatt atcgggttta agatctgcgt gtaaaaagtt 36900
gtcgcaacag ggtagttcgt agattttaat gtataacaga gccatctgta aaaagataaa 36960
ctttatgtat tgtaccaaag atttaaatcc taatttgata gctaactcgg tatctacttt 37020
atctgccgaa tacagtgcta ggggaaaaat tataatattt cctctttcgt attcgtagtt 37080
agttctcttt tcatgttcga aaaagtgaaa catgcggtta aaatagttta taacattaat 37140
attactgtta ataactgccg gataaaagtg ggatagtaat ttcacgaatt tgatactgtc 37200
ctttctctcg ttaaacgcct ttaaaaaaac tttagaagaa tatctcaatg agagttcctg 37260
accatccata gtttgtatca ataatagcaa catatgaaga acccgtttat acagagtatg 37320
taaaaatgtt aatttatagt ttaatcccat ggcccacgca cacacgatta attttttttc 37380
atctcccttt agattgttgt atagaaattt gggtactgtg aactccgccg tagtttccat 37440
gggactatat aattttgtgg cctcgaatac aaattttact acatagttat ctatcttaaa 37500
gactatacca tatcctcctg tagatatgtg ataaaaatcg tcgtttatag gataaaatcg 37560
tttatccttt tgttggaaaa aggatgaatt aatgtaatca ttctcttcta tctttagtag 37620
tgtttcctta ttaaaattct taaaataatt taacaatcta actgacggag cccaattttg 37680
gtgtaaatct aattgggaca ttatgttgtt aaaatacaaa cagtctccta atataacagt 37740
atctgataat ctatggggag acatccattg atattcaggg gatgaatcat tggcaacacc 37800
catttattgt acaaaaagcc ccaatttaca aacgaaagtc caggtttgat agagacaaac 37860
aattaactat tttgtctctg tttttaattt ctttggtaat gaaattattc acaatatcag 37920
tatcttcttt atctaccaga gattttacta acttgataac cttggctgtc tcattcaata 37980
gggtagtaat atttgtatgt gtgatattga tatctttttg aattgtttct tttagaagtg 38040
attctttgat ggtgccagca tacgaattac aataatgcag aaactcagtt aacatgcagg 38100
aattatagta agccaattcc aattgttgcc tgtattgtat tagagtatta atatgcgcaa 38160
tggtgtcctt gcgtttctct gatagaatgc gagcagcgat tttggcgtta tcatttgacg 38220
atatttctgg aatgacgaat cctgtttcta ctaacttttt ggtaggacaa agtgaaacaa 38280
tcaagaagat agcttctcct cctatttgtg gaagaaattg aactcctcta gatgatctac 38340
tgacgatagt atctccttga cagatattgg accgaattac agaagtacct ggaatgtaaa 38400
gccctgaaac cccctcattt tttaagcaga ttgttgccgt aaatcctgca ctgtgaccaa 38460
gatagagagc tcctttggtg aatccatctc tatgtttcag tttaaccaag aaacagtcag 38520
ctggtctaaa atttccatct ctatctaata cagcatctaa cttgatgtca ggaactatga 38580
ccggtttaat gttatatgta acattgagta aatccttaag ttcataatca tcactgtcat 38640
cagttatgta cgatccaaac aatgtttcta ctggcatagt ggatacgaag atgctatcca 38700
tcagaatgtt tccctgatta gtattttcta tatagctatt cttctttaaa cgattttcca 38760
aatcagtaac tatgttcatt tttttaggag taggacgcct agccagtatg gaagaggatt 38820
ttctagatcc tctcttcaac atctttgatc tcgatggaat gcaaaacccc atagtgaaac 38880
aaccaacgat aaaaataata ttgtttttca ctttttataa ttttaccatc tgactcatgg 38940
attcattaat atctttataa gagctactaa cgtataattc tttataactg aactgagata 39000
tatacaccgg atctatggtt tccataattg agtaaatgaa tgctcggcaa taactaatgg 39060
caaatgtata gaacaacgaa attatactag agttgttaaa gttaatattt tctatgagct 39120
gttccaataa attatttgtt gtaactgcgt tcaagtcata aatcatcttg atactatcca 39180
gtaaaccgtg tttaagttct ggaatattat catcccattg taaagcccct aattcgacta 39240
tcgaatatcc tgctctgata gcagtttcaa tatcgacgga cgtcaatact gtaataaagg 39300
tggtagtatt gtcatcatcg tgataaacta cgggaatatg gtcgttagta ggtacggtga 39360
ctttacacaa cgcgatatat aactttcctt ttgtaccatt tttaacgtag ttgggacgtc 39420
ctgcagggta ttgttttgaa gaaatgatat cgagaacaga tttgatacga tatttgttgg 39480
attcctgatt attcactata atataatcta gacagataga tgattcgata aatagagaag 39540
gtatatcgtt ggtaggataa tacatcccca ttccagtatt ctcggatact ctattgatga 39600
cactagttaa gaacatgtct tctattctag aaaacgaaaa catcctacat ggactcatta 39660
aaacttctaa cgctcctgat tgtgtctcga atgcctcgta caaggatttc aaggatgcca 39720
tagattcttt gaccaacgat ttagaattgc gtttagcatc tgattttttt attaaatcga 39780
atggtcggct ctctggtttg ctaccccaat gataacaata gtcttgtaaa gataaaccgc 39840
aagaaaattt atacgcatcc atccaaataa ccctagcacc atcggatgat attaatgtat 39900
tattatagat tttccatcca caattattgg gccagtatac tgttagcaac ggtatatcga 39960
atagattact catgtaacct actagaatga tagttcgtgt actagtcata atatctttaa 40020
tccaatctaa gaaatttaaa attagatttt ttacactgtt aaagttaaca aaggtattac 40080
ccggatacgt ggatatcata tatggcattg gtccattatc agtaatagct ccataaactg 40140
atacggcgat ggtttttata tgtgtttgat ctaacgagga agaaattcgc gcccacaatt 40200
catctctaga tatgtattta atatcaaacg gtaacacatc aatttcggga cgcgtatatg 40260
tttctaaatt tttaatccaa atataatgat gacctatatg ccctattatc atactgtcaa 40320
ctatagtaca cctagagaac ttacgataca tctgtttcct ataatcgtta aattttacaa 40380
atctataaca tgctaaacct tttgacgaca gccattcatt aatttctgat atggaatctg 40440
tattctcgat accgtattgt tctaaagcca gtgctatatc tccctgttcg tgggaacgct 40500
ttcgtataat atcgatcaac ggataatctg aagtttttgg agaataatat gactcatgat 40560
ctatttcgtc cataaacaat ctagacatag gaattggagg cgatgatctt aattttgtgc 40620
aatgagtcgt caatcctata acttctaatc ttgtaatatt catcatcgac ataatactat 40680
ctatgttatc atcgtatatt agtataccac ggccttcttc atttcgtgcc aaaataatat 40740
acagtcttaa ataattacgc aatatctcaa tagtttcata attgttagct gttttcatca 40800
agatttgtac cctgtttaac atgatggcgt tctatacgtc tctattttct tttttttaaa 40860
tttttaacga tttactgtgg ctagataccc aatctctctc aaatattttt ttagcctcgc 40920
ttacaagctg tttatctata ctattaaaac tgacgaatcc gtgattttgg taatgggttc 40980
cgtcgaaatt tgccgaagtg atatgaacat attcgtcgtc gactatcaac aattttgtat 41040
tattctgaat agtgaaaacc ttcacagata gatcattttg aacacacaac gcgtctagac 41100
ttctggcggt tgccatagaa tatacgtcgt tcttatccca attaccaact agaagtctga 41160
tcttaactcc tctattaatg gctgcttcta taatggagtt gtaaatgtcg ggccaatagt 41220
agctattacc gtcgacacgt gtagtgggaa ctatggccaa atgttcaata tctatactag 41280
tcttagccga cttgagttta tcaataacta catcggtatc tagatctcta gaatatccca 41340
ataggtgttc cggagaatca gtaaagaaca ctccacctat aggattctta atatgatacg 41400
cagtgctaac tggcaaacaa caagccgcag agcataaatt caaccatgaa ttttttgcgc 41460
tattaaaggc tttaaaagta tcaaatcttc tacgaagatc tgtggccagc gggggataat 41520
cagaatatac acctaacgtt ttaatcgtat gtatagatcc tccagtaaat gacgcgtttc 41580
ctacataaca tctttcatca tctgacaccc aaaaacaacc gagtagtagt cccacattat 41640
tttttttatc tatattaacg gttataaaat ttatatccgg gcagtgactt tgtagctctc 41700
ccagatttct tttccctcgt tcatctagca aaactattat tttaatccct ttttcagatg 41760
cctcttttag tttatcaaaa ataagcgctc ccctagtcgt actcagagga ttacaacaaa 41820
aagatgctat gtatatatat ttcttagcta gagtgataat ttcgttaaaa cattcaaatg 41880
ttgttaaatg atcggatcta aaatccatat tttctggtag tgtttctacc agcctacatt 41940
ttgctcccgc aggtaccgat gcaaatggcc acatttagtt aacataaaaa cttatacatc 42000
ctgttctatc aacgattcta gaatatcatc ggctatatcg ctaaaatttt catcaaagtc 42060
gacatcacaa cctaactcag tcaatatatt aagaagttcc atgatgtcat cttcgtctat 42120
ttctatatcc gtatccattg tagattgttg accgattatc gagtttaaat cattactaat 42180
actcaatcct tcagaataca atctgtgttt cattgtaaat ttataggcgg tgtatttaag 42240
ttggtagatt ttcaattatg tatcaatata gcaacagtag ttcttgctcc tccttgattc 42300
tagcatcctc ttcattattt tcttctacgt acataagcat gtccaatacg ttagacaaca 42360
caccgacgat ggcggccgcc acagacacga atatgactag accgatgacc atttaaaaac 42420
ccctctctag ctttcactta aactgtatcg attattcttt tagaacatgt ataatataaa 42480
aacattattc tatttcgaat ttaggcttcc aaaaattttt catccgtaaa ccgataataa 42540
tatatataga cttgttaata gtcggaataa atagattaat gcttaaacta tcatcatctc 42600
cacgattaga gatacaatat ttacattttt tttgctgttt cgaaacttta tcaatacacg 42660
ttaatacaaa cccaggaagg agatattgaa actgaggctg ttgaaaatga aacggtgaat 42720
acaataattc agataatgta aaatcatgat tccgtattct gatgatatta gaactgctaa 42780
tggatgtcga tggtatgtat ctaggagtat ctattttaac aaagcatcga tttgctaata 42840
tacaattatc cttttgatta attgttattt tattcatatt cttaaaaggt ttcatattta 42900
tcaattcttc tacattaaaa atttccattt ttaatttatg tagcccccgc aatactcctc 42960
attacgtttc attttttgtc tataatatcc attttgttca tctcggtaca tagattatcc 43020
aattgagaag cgcatttagt agttttgtac attttaagtt tattgacgaa tcgtcgaaaa 43080
ctagttatag ttaacatttt attatttgat accctgatat taatacccct gccgttacta 43140
ttatttataa ctgatgtaat ccacgtaaca ttagaattaa ttatcgatag taatgcatcg 43200
acgcttccaa aattgtctat tataaactca ccgataattt ttttattgca tgttttcata 43260
ttcattagga ttatcaaatc tttaatctta ctacgattgt atgcgttgat attgcaagac 43320
gtcattctaa aagacggagg atctccatca aatgccagac aatcacgtac aaagtacatg 43380
gaaataggtt ttgttctatt gcgcatcata gatttatata gaacacccgt agaaatacta 43440
atttgtttta ctctataaaa tactaatgca tctatttcat cgttttgtat aacgtctttc 43500
caagtgtcaa attccaaatt tttttcattg atagtaccaa attcttctat ctctttaact 43560
acttgcatag ataggtaatt acagtgatgc ctacatgccg ttttttgaaa ctgaatagat 43620
gcgtctagaa gcgatgctac gctagtcaca atcaccactt tcatatttag aatatatgta 43680
tgtaaaaata tagtagaatt tcattttgtt tttttctatg ctataaatga attctcattt 43740
tgcatctgct catactccgt tttatatcaa taccaaagaa ggaagatatc tggttctaaa 43800
agccgttaaa gtatgcgatg ttagaactgt agaatgcgaa ggaagtaaag cttcctgcgt 43860
actcaaagta gataaaccct catcgcccgc gtgtgagaga agaccttcgt ccccgtccag 43920
atgcgagaga atgaataacc ctggaaaaca agttccgttt atgaggacgg acatgctaca 43980
aaatatgttc gcggctaatc gcgacaacgt ggcgtcgaga cttttgaact aaaatacaat 44040
tatatccttt tcgatattaa taaatccgtg tcgtccaggt tttttatctc tttcagtatg 44100
tgaatagata ggtattttat ctctattcat catcgaattt aagagatccg ataaacattg 44160
tttgtattct ccagatgtca gcatctgata caacaatata tgtgcacata aacctctggc 44220
acttatttca tgtaccttcc ccttatcact aaggagaata gtatttgaga aatatgtata 44280
catgatatta tcatgaatta gatatacaga atttgtaaca ctctcgaaat cacacgatgt 44340
gtcggcgtta agatctaata tatcactcga taacacattt tcatctagat acactagaca 44400
ttttttaaag ctaaaatagt ctttagtagt gacagtaact atgcgattat tttcatcgat 44460
gatacatttc atcggcatat tattacgctt accatcaaag actataccat gtgtatatct 44520
aacgtattct agcatggttg ccatacgcgc attaaacttt tcaggatctt tggatagatc 44580
ttccaatcta tctatttgag aaaacatttt tatcatgttc aatagttgaa acgtcggatc 44640
cactatatag atattatcta taaagatttt aggaactacg ttcatggtat cctggcgaat 44700
attaaaacta tcaatgatat gattatcgtt ttcatctttt atcaccatat agtttctaag 44760
atatgggatt ttacttaata taatattatt tcccgtgata aattttatta gaaaggccaa 44820
atctataaga aaagttctag aattagtctg aagaatatct atatcgccgt accgtatatt 44880
tggattaatt agatatagag aatatgatcc gtaacatata caacttttat tatggcgtct 44940
aagatattct tccatcaact tattaacatt tttgactagg gaagatacat tatgacgtcc 45000
cattactttt gccttgtcta ttactgcgac gttcatagaa tttagcatat ctcttgccaa 45060
ttcttccatt gatgttacat tataagaaat tttagatgaa attacatttg gagctttaat 45120
agtaagaact cctaatatgt ccgtgtatgt ggtcactaat acagattgta gttctataat 45180
cgtaaataat ttacctatat tatatgtttg agtctgttta gaaaagtagc taagtatacg 45240
atcttttatt tctgatgcag atgtattaac atcggaaaaa aatctttttt tattcttttt 45300
tactaaagat acaaatatgt ctttgttaaa aacagttatt ttttgaatat ttctagcttg 45360
taattttaac atatgatatt cgttcacact aggtactctg cctaaatagg tttctataat 45420
ctttaatgta atattaggaa gagtattctg atcaggattc ctattcattt tgaggattta 45480
aaactctgat tattgtctaa tatggtctct acgcaaactt tttcacagag cgatagagtt 45540
tttgataact cgtttttctt aagaaatata aaactactgt ctccagagct cgctctatct 45600
tttattttat ttaattcgat acaaactcct gatactggtt cagaaagtaa ttcattaatt 45660
ttcagtcctt tatagaagat atttaatata gataatacaa aattttcagt tcttgatatc 45720
gatctgattg atcctagaac tagatatatt aataacgtgc tcattaggca gtttatggca 45780
gcttgataat tagatatagt atattccagt tcatatttat tagataccgc attgcccaga 45840
ttttgatatt ctatgaattc ctctgaaaat aaatccaaaa taactaaaca ttctattttt 45900
tgtggattag tgtactctct tccctctatc atgttcacta ctggtgtcca cgatgataaa 45960
tatctagagg gaatataata tagtccatag gatgccaatc tagcaatgtc gaataactgt 46020
aatttgattc ttcgttcttc attatgaatt gattcttgag gtataaacct aacacaaatt 46080
atattattag acttttcgta tgtaatgtct ttcatgttat aagtttttaa tcctggaata 46140
gaatctattt taatgaggct tttaaacgca gagttctcca acgagtcaaa gcataatact 46200
ctgttgtttt tcttatatac gatgttacga ttttcttctt tgaatggaat aggtttttga 46260
attagtttat aattacaaca taatagataa ggaagtgtgc aaatagtacg cggaaaaaac 46320
ataatagctc ccctgttttc atccatggtt ttaagtaaat gatcactggc ttctttagtc 46380
aatggatatt cgaacattaa ccgtttcatc atcattggac agaatccata tttcttaatg 46440
taaagagtga tcaaatcatt gtgtttattg taccatcttg ttgtaaatgt gtattcggtt 46500
atcggatctg ctcctttttc tattaaagta tcgatgtcga tctcgtctaa gaattcaact 46560
atatcgacat atttcatttg tatacacata accattacta acgtagaatg tataggaaga 46620
gatgtaacgg gaacagggtt tgttgattcg caaactattc taatacataa ttcttctgtt 46680
aatacgtctt gcacgtaatc tattatagat gccaagatat ctatataatt attttgtaag 46740
atgatgttaa ctatgtgatc tatataagta gtgtaataat tcatgtattt cgatatatgt 46800
tccaactctg tctttgtgat gtctagtttc gtaatatcta tagcatcctc aaaaaatata 46860
ttcgcatata ttcccaagtc ttcagttcta tcttctaaaa aatcttcaac gtatggaata 46920
taataatcta ttttacctct tctgatatca ttaatgatat agtttttgac actatcttct 46980
gtcaattgat tcttattcac tatatctaag aaacggatag cgtccctagg acgaactact 47040
gccattaata tctctattat agcttctgga cataattcat ctattatacc agaattaatg 47100
ggaactattc cgtatctatc taacatagtt ttaagaaagt cagaatctaa gacctgatgt 47160
tcatatattg gttcatacat gaaatgatct ctattgatga tagtgactat ttcattctct 47220
gaaaattggt aactcattct atatatgctt tccttgttga tgaaggatag aatatactca 47280
atagaatttg taccaacaaa ctgttctctt atgaatcgta tatcatcatc tgaaataatc 47340
atgtaaggca tacatttaac aattagagac ttgtctcctg ttatcaatat actattcttg 47400
tgataattta tgtgtgaggc aaatttgtcc acgttcttta attttgttat agtagatatc 47460
aaatccaatg gagctacagt tcttggctta aacagatata gtttttctgg aacgaattct 47520
acaacattat tataaaggac tttgggtaga taagtgggat gaaatcctat tttaattaat 47580
gcgatagcct tgtcctcgtg cagatatcca aacgcttttg tgatagtatg gcattcattg 47640
tctagaaacg ctctacgaat atctgtgaca gatatcatct ttagagaata tactagtcgc 47700
gttaatagta ctacaatttg tattttttaa tctatctcaa taaaaaaatt aatatgtatg 47760
attcaatgta taactaaact actaactgtt attgataact agaatcagaa tctaatgatg 47820
acgtaaccaa gaagtttatc tactgccaat ttagctgcat tatttttagc atctcgttta 47880
gattttccat ctgccttatc gaatactctt ccgtcgatgt ctacacaggc ataaaatgta 47940
ggagagttac taggccccac tgattcaata cgaaaagacc aatctctcct agtaatttgg 48000
cagtactcat taataacggt gacagggtta gcacctttcc aatcaataat ttttttagcc 48060
ggaataacat catcaaaaga cttatgatcc tctctcattg atttttcgcg ggatacatca 48120
tctattatga cgtcagccat agcatcagca tccggcttat ccgcctccgt tgtcataaac 48180
caacgaggag gaatatcgtc ggagctgtac accatagcac tacgttgaag atcgtacaga 48240
gctttattaa cttctcgctt ctccatatta agttgtctag ttagttgtgc agcagtagct 48300
ccttcgattc caatggtttt aatagcctca cacacaatct ctgcgttaga acgctcgtcg 48360
atatagattt tagacatttt tagagagaac taacgcaatc agtaataaaa ctaatttatt 48420
ttatcatttt ttttattcat catcctctgg tggttcgtcg tttctatcga atgtagctct 48480
gattaacccg tcatctatag gtgatgctgg ttctggagat tctggaggag atggattatt 48540
atctggaaga atctctgtta tttccttgtt ttcatgtatc gattgcgttg taacattaag 48600
attgcgaaat gctctaaatt tgggaggctt aaagtgttgt ttgcaatctc tacacgcgtg 48660
tctaactagt ggaggttcgt cagcggctct agtttgaatc atcatcggcg tagtattcct 48720
acttttacag ttaggacacg gtgtattgta tttctcgtcg agaacgttaa aataatcgtt 48780
gtaactcaca tcctttattt tatctatatt gtattctact cctttcttaa tgcattttat 48840
accgaataag agatagcgaa ggaattcttt ttcggtgccg ctagtaccct taatcatatc 48900
acatagtgtt ttatattcca aatttgtggc aatagacggt ttatttctat acgatagttt 48960
gtttctggaa tcctttgagt attctatacc aatattattc tttgattcga atttagtttc 49020
ttcgatatta gattttgtat tacctatatt cttgatgtag tactttgatg atttttccat 49080
ggcccattct attaagtctt ccaagttggc atcatccaca tattgtgata gtaattctcg 49140
gatatcagta gcggttaccg ccattgatgt ttgttcattg gatgagtaac tactaatgta 49200
tacattttcc atttataaca cttatgtatt aactttgttc atttatattt tttcattatt 49260
atgttgatat taacaaaagt gaatatatat atgttaataa ttgtattgtg gttatacggc 49320
tacaatttta taattagtga aagtcagtgt ccgatgatca atgacgatag ctttactctg 49380
aaaagaaagt atcaaatcga tagtgcggag tcaacaataa aaatggataa gaagaggaca 49440
aagtttcaga atagagccaa aatggtaaaa gaaataaatc agacaataag agcagcacaa 49500
actcattacg agacattgaa actaggatac ataaaattta agagaatgat taggactact 49560
actctagaag atatagcacc atctattcca aataatcaga aaacttataa actattctcg 49620
gacatttcag ccatcggcaa agcatcacgg aatccaagta agatggtata tgctctgctg 49680
ctttacatgt ttcccaattt gtttggagat gatcatagat tcattcgtta tagaatgcat 49740
ccaatgagta aaatcaaaca caagatcttc tctcctttca aacttaatct tattagaata 49800
ttagtggaag aaagattcta taataatgaa tgcagatcta ataaatggag aataattgga 49860
acacaagttg ataaaatgtt gatagctgaa tctgataaat atacaataga tgcaaggtat 49920
aacctaaaac ccatgtatag aatcaaggga aaatctgaag aagataccct ctttatcaaa 49980
cagatggtag aacaatgtgt gacatcccag gaattggtgg aaaaagtgtt gaagatactg 50040
tttagagatt tgttcaagag tggagaatac aaagcgtaca gatacgatga tgatgtagaa 50100
aatggattta ttggattgga tacactaaaa ttaaacattg ttcatgatat agttgaacca 50160
tgtatgcctg ttcgtaggcc agtggctaag atactgtgta aagaaatggt aaataaatac 50220
tttgagaatc cgctacatat tattggtaaa aatcttcaag agtgcattga ctttgttagt 50280
gaataggcat ttcatctttc tccaatacta attcaaattg ttaaattaat aatggatagt 50340
ataaatagtt attagtgata aaatagtaaa aataattatt agaataagag tgtagtatca 50400
tagataactc tcttctataa aaatggattt tattcgtaga aagtatctta tatacacagt 50460
agaaaataat atagattttt taaaggatga tacattaagt aaagtaaaca attttaccct 50520
caatcatgta ctagctctca agtatctagt tagcaatttt cctcaacatg ttattactaa 50580
ggatgtatta gctaatacca atttttttgt tttcatacat atggtacgat gttgtaaagt 50640
gtacgaagcg gttttacgac acgcatttga tgcacccacg ttgtacgtta aagcattgac 50700
taagaattat ttatcgttta gtaacacaat acaatcgtac aaggaaaccg tgcataaact 50760
aacacaagat gaaaaatttt tagaggttgc caaatacatg gacgaattag gagaacttat 50820
aggcgtaaat tatgacttag ttcttaatcc attatttcac ggaggggaac ccatcaaaga 50880
tatggaaatc atttttttaa aactgtttaa gaaaacagac ttcaaagttg ttaaaaaatt 50940
aagtgttata agattactta tttgggctta cctaagcaag aaagatacag gcatagagtt 51000
tgcggataat gatagacaag atatatatac tctatttcaa caaactggta gaatcgtcca 51060
tagcaatcta acagaaacgt ttagagatta tatctttccc ggagataaga ctagctattg 51120
ggtgtggtta aacgaaagta tagctaatga tgcggatatt gttcttaata gacacgccat 51180
taccatgtat gataaaattc ttagttatat atactctgag ataaaacaag gacgcgttaa 51240
taaaaacatg cttaagttag tttatatctt tgagcctgaa aaagatatca gagaacttct 51300
gctagaaatc atatatgata ttcctggaga tatcctatct attattgatg caaaaaacga 51360
cgattggaaa aaatatttta ttagttttta taaagctaat tttattaacg gtaatacatt 51420
tattagtgat agaacgttta acgaggactt attcagagtt gttgttcaaa tagatcccga 51480
atatttcgat aatgaacgaa ttatgtcttt attctctacg agtgctgcgg acattaaacg 51540
atttgatgag ttagatatta ataacagtta tatatctaat ataatttatg aggtgaacga 51600
tatcacatta gatacaatgg atgatatgaa gaagtgtcaa atctttaacg aggatacgtc 51660
gtattatgtt aaggaataca atacatacct gtttttgcac gagtcggatc ccatggtcat 51720
agagaacgga atactaaaga aactgtcatc tataaaatcc aagagtagac ggctgaactt 51780
gtttagcaaa aacattttaa aatattattt agacggacaa ttggctcgtc taggtcttgt 51840
gttagatgat tataaaggag acttgttagt taaaatgata aaccatctta agtctgtgga 51900
ggatgtatcc gcattcgttc gattttctac agataaaaac cctagtattc ttccatcgct 51960
aatcaaaact attttagcta gttataatat ttccatcatc gtcttatttc aaaggttttt 52020
aagagataat ctatatcatg tagaagaatt cttggataaa agcatccatc taaccaagac 52080
ggataagaaa tatatacttc aattgataag acacggtaga tcatagaaca gaccaaatat 52140
attattaata atttgtatat acatagatat aattatcaca tattaaaaat tcacacattt 52200
ttgataaatg ggaactgctg caacaattca gactcccacc aaattaatga ataaagaaaa 52260
tgcagaaatg attttggaaa aaattgttga tcatatagtt atgtatatta gtgacgaatc 52320
aagtgattca gaaaataatc ctgaatatat tgattttcgt aacagatacg aagactatag 52380
atctctcatt ataaaaagtg atcacgagtt tgtaaagcta tgtaaaaatc atgcagagaa 52440
aagttctcca gaaacgcaac aaatgattat caaacacata tacgaacaat atcttattcc 52500
agtatctgaa gtactattaa aacctataat gtccatgggt gacataatta catataacgg 52560
atgtaaagac aatgaatgga tgctagaaca actctctacc ctaaacttta acaatctccg 52620
cacatggaac tcatgtagca taggcaatgt aacgcgtctg ttttatacat tttttagtta 52680
tctgatgaaa gataaactaa atatataagt ataatcccat tctaatactt taacctgatg 52740
tattagcatc ttattagaat attaacctaa ctaaaagaca taacataaaa actcattaca 52800
tagttgataa aaagcggtag gatataaata ttatggctgc caccgttccg cgttttgacg 52860
acgtgtacaa aaatgcacaa agaagaattc tagatcaaga aacatttttt agtagaggtc 52920
taagtagacc gttaatgaaa aacacatatc tatttgataa ttacgcgtat ggatggatac 52980
cagaaactgc aatttggagt agtagatacg caaacttaga tgcaagtgac tattatccca 53040
tttcgttggg attacttaaa aagttcgagt ttctcatgtc tctatataaa ggtcctattc 53100
cagtatacga agaaaaagta aatactgaat tcattgctaa tggatcgttc tctggtagat 53160
acgtatcata tcttcgaaag ttttctgctc ttccaacaaa cgagtttatt agttttttgt 53220
tactgacttc cattccaatc tataatatct tgttctggtt taaaaatact cagtttgata 53280
ttactaaaca cacattattc agatacgtct atacagataa tgccaaacac ctggcgttgg 53340
ctaggtatat gcatcaaaca ggagactata agcctttgtt tagtcgtctc aaagagaatt 53400
atatatttac cggtcccgtt ccaataggta tcaaagatat aaatcaccct aatcttagta 53460
gagcaagaag tccatccgat tatgagacat tagctaatat tagtactata ttgtacttta 53520
ccaagtatga tccggtatta atgtttttat tgttttacgt acctgggtat tcaattacta 53580
caaaaattac tccagccgta gaatatctaa tggataaact gaatctaaca aagagcgacg 53640
tacaactgtt gtaaattatt ttatgcttcg taaaatgtag gttttgaacc aaacattctt 53700
tcaaagaatg agatgcataa aactttatta tccaatagat tgactatttc ggacgtcaat 53760
cgtttaaagt aaacttcgta aaatattctt tgatcactgc cgagtttaaa acttctatcg 53820
ataattgttt catatgtttt aatatttaca agttttttgg tccatggtac attagccgga 53880
caaatatatg caaaataata tcgttctcca agttctatag tttctggatt atttttatta 53940
tattcagtaa ccaaatacat attagggtta tctgcggatt tataatttga gtgatgcatt 54000
cgactcaaca taaataattc tagaggagac gatctactat caaattcgga tcgtaaatct 54060
gtttctaaag aacggagaat atctatacat acctgattag aattcatccg tccttcagac 54120
aacatctcag acagtctggt cttgtatgtc ttaatcatat tcttatgaaa cttggaaaca 54180
tctcttctag tttcactagt acctttatta attctctcag gtacagattt tgaattcgac 54240
gatgccgagt atttcatcgt tgtatatttc ttcttcgatt gcataatcag attcttatat 54300
accgcctcaa actctatttt aaaattatta aacaatactc tattattaat cagtcgttct 54360
aactcctttg ctatttctat ggacttatct acatcttgac tgtctatctc tgtaaacacg 54420
gagtcggtat ctccatacac gctacgaaaa cgaaatctgt aatctatagg caacgatgtt 54480
ttcacaatcg gattaatatc tctatcgtcc atataaaatg gattacttaa tggattggca 54540
aaccgtaaca taccgttaga taactctgct ccatttagta ccgattctag atacaagatc 54600
attctacgtc ctatggatgt gcaactctta gccgaagcgt atgagtatag agcactattt 54660
ctaaatccca tcagaccata tactgagttg gctactatct tgtacgtata ttgcatggaa 54720
tcatagatgg ccttttcagt tgaactggta gcctgtttta acatcttttt atatctggct 54780
ctctctgcca aaaatgttct taatagtcta ggaatggttc cttctatcga tctatcgaaa 54840
attgctattt cagagatgag gttcggtagt ctaggttcac aatgaaccgt aatatatcta 54900
ggaggtggat atttctgaag caagagctga ttatttattt cttcttccaa tctattggta 54960
ctaacaacga caccgactaa tgtttccgga gatagatttc caaagataca cacattagga 55020
tacagactgt tataatcaaa gattaataca ttattactaa acattttttg ttttggagca 55080
aataccttac cgccttcata aggaaacttt tgttttgttt ctgatctaac taagatagtt 55140
ttagtttcca acaatagctt taacagtgga cccttgatga ctgtactcgc tctatattcg 55200
aataccatgg attgaggaag cacatatgtt gacgcacccg cgtctgtttt tgtttctact 55260
ccataatact cccacaaata ctgacacaaa caagcatcat gaatacagta tctagccata 55320
tctaaagcta tgtttagatt ataatcctta tacatctgag ctaaatcaac gtcatccttt 55380
ccgaaagata atttatatgt atcattaggt aaagtaggac ataatagtac gactttaaat 55440
ccattttccc aaatatcttt acgaattact ttacatataa tatcctcatc aacagtcaca 55500
taattacctg tggttaaaac ctttgcaaat gcagcggctt tgcctttcgc gtccgtagta 55560
tcgtcaccga tgaacgtcat ttctctaact cctctattta atactttacc catgcaactg 55620
aacgcgttct tggatataga atccaatttg tacgaatcca atttttcaga tttttgaatg 55680
aatgaatata gatcgaaaaa tatagttcca ttattgttat taacgtgaaa cgtagtattg 55740
gccatgccgc ctactccctt atgactagac tgatttctct cataaataca gagatgtaca 55800
gcttcctttt tgtccggaga tctaaagata atcttctctc ctgttaataa ctctagacga 55860
ttagtaatat atctcagatc aaagttatgt ccgttaaagg taacgacata gtcgaacgtt 55920
agttccaaca attgtttagc tattcgtaac aaaactattt cagaacataa aactagttct 55980
cgttcgtaat ccatttccat tagtgactgt atcctcaaac atcctctatc gacggcttct 56040
tgtatttcct gttccgttaa catctcttca ttaatgagcg taaacaataa tcgtttacca 56100
cttaaatcga tataacagta acttgtatgc gagattgggt taataaatac agaaggaaac 56160
ttcttatcga agtgacactc tatatctaga aataagtacg atcttgggat atcgaatcta 56220
ggtatttttt tagcgaaaca gttacgtgga tcgtcacaat gataacatcc attgttaatc 56280
tttgtcaaat attgctcgtc caacgagtaa catccgtctg gagatatccc gttagaaata 56340
taaaaccaac taatattgag aaattcatcc atggtggcat tttgtatgct gcgtttcttt 56400
ggctcttcta tcaaccacat atctgcgacg gagcattttc tatctttaat atctagatta 56460
taacttattg tctcgtcaat gtctatagtt ctcatctttc ccaacggcct cgcattaaat 56520
ggaggaggag acaatgactg atatatttcg tccgtcacta cgtaataaaa gtaatgagga 56580
aatcgtataa atacggtctc accatttcga catctggatt tcagatataa aaatctgttt 56640
tcaccgtgac tttcaaacca attaatgcac cgaacatcca tttatagaat ttagaaatat 56700
attttcattt aaatgaatcc caaacattgg ggaagagccg tatggaccat tatttttata 56760
gtactttcgc aagcgggttt agacggcaac atagaagcgt gtaaacgaaa actatatact 56820
atagttagca ctcttccatg tcctgcatgt agacggcacg cgactatcgc tatagaggac 56880
aataatgtca tgtctagcga tgatctgaat tatatttatt attttttcat cagattattt 56940
aacaatttgg catctgatcc caaatacgcg atcgatgtga caaaggttaa ccctttataa 57000
acttaaccca ttataaaact tatgattagt cacgactgaa ataaccgcgt gattattttt 57060
tggtataatt ctacacggca tggtttctgt gactatgaat tcaacccccg ttacattagt 57120
gaaatcttta acaaacagca agggttcgtc aaagacataa aactcattgt ttacaatcga 57180
aatagacccc ctatcacact taaaataaaa aatatcctta tcctttacca ccaaataaaa 57240
ttctgattgg tcaatgtgaa tgtattcact taacagttcc acaaatttat ttattaactc 57300
cgaggcacat acatcgtcgg tattttttat ggcaaacttt actcttccag catccgtttc 57360
taaaaaaata ttaacgagtt ccatttatat catccaatat tattgaaatg acgttgatgg 57420
acaaatgata caaataagaa ggtacggtac ctttgtccac catctcctcc aattcatgct 57480
ctattttgtc attaacttta atgtatgaaa acagtacgcc acatgcttcc atgacagtgt 57540
gtaacacttt ggatacaaaa tgtttgacat tagtataatt gttcaagact gtcaatctat 57600
aatagatagt agctataata tattctatga tggtattgaa gaagatgaca accttggcat 57660
attgatcatt taacacagac atggtatcaa cagatagctt gaatgaaaga gaatcagtaa 57720
ttggaataag cgtcttctcg atggagtgtc cgtataccaa catgtctgat attttgatgt 57780
attccattaa attatttagt tttttctttt tattctcgtt aaacagcatt tctgtcaacg 57840
gaccccaaca tcgttgaccg attaagtttt gattgatttt tccgtgtaag gcgtatctag 57900
tcagatcgta tagcctatcc aataatccat cgtctgtgtg tagatcacat cgtacacttt 57960
ttaattctct atagaagagc gacagacatc tggagcaatt acagacagca atttctttat 58020
tctctacaga tgtaagatac ttgaagacat tcctatgatg atgcagaatt ttggataaca 58080
cggtattgat ggtatctgtt accataattc ctttgatggc tgatagtgtc agagcacaag 58140
atttccaatc tttgacaatt tttagcacca ttatctttgt tttgatatct atatcagaca 58200
gcatggtgcg tctgacaaca caaggattaa gacggaaaga tgaaatgatt ctctcaacat 58260
cttcaatgga taccttgcta ttttttctgg cattatctat atgtgcgaga atatcctcta 58320
gagaatcagt atcctttttg atgatagtgg atctcaatga catgggacgt ctaaaccttc 58380
ttattctatc accagattgc atggtgattt gtcttctttc ttttatcata atgtaatctc 58440
taaattcatc ggcaaattgt ctatatctaa aatcataata tgagatgttt acctctacaa 58500
atatctgttc gtccaatgtt agagtattta catcagtttt gtattccaaa ttaaacatgg 58560
caacggattt aattttatat tcctctatta agtcctcgtc gataataaca gaatgtagat 58620
aatcatttaa tccatcgtac atggttggaa gatgctcgtt gacaaaatct ttaattgtct 58680
tgatgaaggt gggactatat ctaacatctt gattaataaa atttataaca ttgtccatag 58740
gatactttgt aactagtttt atacacatct cttcatcggt aagtttagac agaatatcgt 58800
gaacaggtgg tatattatat tcatcagata tacgaagaac aatgtccaaa tctatattgt 58860
ttaatatatt atatagatgt agtgtagctc ctacaggaat atctttaact aagtcaatga 58920
tttcatcaac cgttagatct attttaaagt taatcatata ggcattgatt tttaaaaggt 58980
atgtagcctt gactacattc tcattaatta accattccaa gtcactgtgt gtaagaagat 59040
tatattctat cataagcttg actacatttg gtcccgatac cattaaagaa ttcttatgat 59100
ataaggaaac agattttagg tactcatcta ctctacaaga attttggaga gccttaacga 59160
tatcagtgac gtttattatt tcaggaggaa aaaacctaac attgagaata tcggaattaa 59220
tagcttccag atacagtgat tttggcaata gtccgtgtaa tccataatcc agtaacacga 59280
gctggtgctt gctagacacc ttttcaatgt ttaatttttt tgaaataagc tttgataaag 59340
ccttcctcgc aaattccgga tacatgaaca tgtcggcgac atgattaagt attgtttttt 59400
cattattttt atattttctc aacaagttct caatacccca atagatgata gaatatcacc 59460
caatgcgtcc atgttgtcta tttccaacag gtcgctatat ccaccaatag aagttttccc 59520
aaaaaagatt ctaggaacag ttctaccacc agtaatttgt tcaaaatagt cacgcaattc 59580
attttcgggt ttaaattctt taatatcgac aatttcatac gctcctcttt tgaaactaaa 59640
cttatttaga atatccagtg catttctaca aaaaggacat gtatacttga caaaaattgt 59700
cactttgtta ttggccaacc tttgttgtac aaattcctcg gccattttaa tatttaagtg 59760
atataaaact atctcgactt atttaactct ttagtcgaga tatatggacg cagatagcta 59820
tatgatagcc aactacagaa ggcaaacgct ataaaaaaca taattacgac gagcatattt 59880
ataaatattt ttattcagca ttacttgata tagtaatatt aggcacagtc aaacattcaa 59940
ccactctcga tacattaact ctctcatttt ctttaacaaa ttctgcaata tcttcgtaaa 60000
aagattcttg aaacttttta gaatatctat cgactctaga tgaaatagcg ttcgtcaaca 60060
tactatgttt tgtatacata aaggcgccca ttttaacagt ttctagtgac aaaatgctag 60120
cgatcctagg atcctttaga atcacataga ttgacgattc gtctctctta gtaactctag 60180
taaaataatc atacaatcta gtacgcgaaa taatattatc cttgacttga ggagatctaa 60240
acaatctagt tttgagaaca tcgataagtt catcgggaat gacatacata ctatctttaa 60300
tagaactctt ttcatccagt tgaatggatt cgtccttaac caactgatta atgagatctt 60360
ctattttatc attttccaga tgatatgtat gtccattaaa gttaaattgt gtagcgcttc 60420
tttttagtct agcagccaat actttaacat cactaatatc gatatacaaa ggagatgatt 60480
tatctatggt attaagaatt cgtttttcga catctgtcaa aaccaattcc tttttgcctg 60540
tatcatccag ttttccatcc tttgtaaaga aattattttc tactagacta ttaataagac 60600
tgataaggat tcctccataa ttgcacaatc caaacttttt cacaaaacta gactttacaa 60660
gatctacagg aatgcgtact tcaggtttct tagcttgtga ttttttcttt tgtggacatt 60720
ttcttgtgac caactcatct accatttcat tgattttagc agtgaaataa gctttcaatg 60780
cacgggcact gatactattg aaaacgagtt gatcttcaaa ttccgccatt taagttcacc 60840
aaacaacttt taaatacaaa tatatcaata gtagtagaat aagaactata aaaaaaataa 60900
taattaacca ataccaaccc caacaaccgg tattattagt tgatgtgact gttttctcat 60960
cacttagaac agatttaaca atttctataa agtctgtcaa atcatcttcc ggagacccca 61020
taaatacacc aaatatagcg gcgtacaact tatccattta tacattgaat attggctttt 61080
ctttatcgct atcttcatca tattcatcat caatatcaac aagtcccaga ttacgagcca 61140
gatcttcttc tacattttca gtcattgata cacgttcact atctccagag agtccgataa 61200
cgttagccac cacttctcta tcaatgatta gtttcttgag tgcgaatgta atttttgttt 61260
ccgttccgga tctatagaaa actacaggtg tgataattgc cttggccaat tgtctttctc 61320
ttttactgag tgattctagt tcaccttcta tagatctgag aatggatgat tctccagtcg 61380
aaacatattc taccatggct ccgtttaatt tgttgatgaa gatggattca tccttaaatg 61440
ttttctctgt aatagtttcc accgaaagac tatgcaaaga atttggaatg cgttccttgt 61500
gcttaatgtt tccatagacg gcttctagaa gttgatacaa cataggacta gccgcggtaa 61560
cttttatttt tagaaagtat ccatcgcttc tatcttgttt agatttattt ttataaagtt 61620
tagtctctcc ttccaacata ataaaagtgg aagtcatttg actagataaa ctatcagtaa 61680
gttttataga gatagacgaa caattagcgt attgagaagc atttagtgta acgtattcga 61740
tacattttgc attagattta ctaatcgatt ttgcatactc tataacaccc gcacaagtct 61800
gtagagaatc gctagatgca gtaggtcttg gtgaagtttc aactctcttc ttgattacct 61860
tactcatgat taaacctaaa taattgtact ttgtaatata atgatatata ttttcacttt 61920
atctcatttg agaataaaaa tgtttttgtt taaccactgc atgatgtaca gatttcggaa 61980
tcacaaacca ccggtggttt tattttatcc ttgtccaatg tgaattgaat gggagcggat 62040
gcgggtttcg tacgtagata gtacattccc gtttttagac cgagactcca tccgtaaaaa 62100
tgcatactcg ttagtttgga ataactcgga tctgctatat ggatattcat agattgactt 62160
tgatcgatga aggctcccct gtctgcagcc atttttatga tcgtcttttg tggaatttcc 62220
caaatagttt tataaactcg cttaatatct tctggaaggt ttgtattctg aatggatcca 62280
ccatctgcca taatcctatt cttgatctca tcattccata attttctctc ggttaaaact 62340
ctaaggagat gcggattaac tacttgaaat tctccagaca atactctccg agtgtaaata 62400
ttactggtat acggttccac cgactcatta tttcccaaaa tttgagcagt tgatgcagtc 62460
ggcataggtg ccaccaataa actatttcta agaccgtatg ttctgatttt atcttttaga 62520
ggttcccaat tccaaagatc cgacggtaca acattccaaa gatcatattg tagaataccg 62580
ttactggcgt acgatcctac atatgtatcg tatggtcctt ccttctcagc tagttcacaa 62640
ctcgcctcta atgcaccgta ataaatggtt tcgaagatct tcttatttag atcttgtgct 62700
tccaggctat caaatggata atttaagaga ataaacgcgt ccgctaatcc ttgaacacca 62760
ataccgatag gtctatgtct cttattagag atttcagctt ctggaatagg ataataatta 62820
atatctataa ttttattgag atttctgaca attactttga ccacatcctt cagtttgaga 62880
aaatcaaatc gcccatctat tacaaacatg ttcaaggcaa cagatgccag attacaaacg 62940
gctacctcat tagcatccgc atattgtatt atctcagtgc aaagattact acacttgata 63000
gttcctaaat tttgttgatt actctttttg ttacacgcat ccttataaag aatgaatgga 63060
gtaccagttt caatctgaga ttctataatc gctttccaga cgactcgagc ctttattata 63120
gatttgtatc tcctttctct ttcgtatagt gtatacaatc gttcgaactc gtctccccaa 63180
acattgtcca atccaggaca ttcatccgga cacatcaacg accactctcc gtcatccttc 63240
actcgtttca taaagagatc aggaatccaa agagctataa atagatctct ggttctatgt 63300
tcctcgtttc ctgtattctt tttaagatcg aggaacgcca taatatcaga atgccacggt 63360
tccaagtata tggccataac tccaggccgt ttgtttcctc cctgatctat gtatctagcg 63420
gtgttattat aaactctcaa cattggaata ataccgtttg atataccatt ggtaccggag 63480
atatagcttc cactggcacg aatattacta attgatagac ctattccccc tgccatttta 63540
gagattaatg cgcatcgttt taacgtgtca tagataccct ctatgctatc atcgatcatg 63600
ttaagtagaa aacagctaga catttggtga cgactagttc ccgcattaaa taaggtagga 63660
gaagcgtgcg taaaccattt ttcagaaagt agattgtacg tctcaatagc tgagtctata 63720
tcccattgat gaattcctac tgcgacacgc attaacatgt gctgaggtct ttcaacgatc 63780
ttgttgttta ttttcaacaa gtaggatttt tccaaagttt taaaaccaaa atagttgtat 63840
gaaaagtctc gttcgtaaat aataaccgag ttgagtttat ccttatattt gttaactata 63900
tccatggtga tacttgaaat aatcggagaa tgtttcccat ttttaggatt aacatagttg 63960
aataaatcct ccatcacttc actaaatagt ttttttgttt ccttgtgtag atttgatacg 64020
gctattctgg cggctagaat ggcataatcc ggatgttgtg tagtacaagt ggctgctatt 64080
tcggctgcca gagtgtccaa ttctaccgtt gttactccat tatatattcc ttgaataacc 64140
ttcatagcta ttttaatagg atctatatga tccgtgttta agccataaca taattttcta 64200
atacgagacg tgattttatc aaacatgaca ttttccttgt atccatttcg tttaatgaca 64260
aacatttttg ttggtgtaat aaaaaaatta tttaactttt cattaatagg gatttgacgt 64320
acgtagcgta caaaatgatt gttcctggta tatagataaa gagtcctata tatttgaaaa 64380
tcgttacggc tcgattaaac tttaatgatt gcatagtgaa tatatcatta ggatttaact 64440
ccttgactat cagggcggca ccagaaatta ccatcaaaag cattaataca gttatgccta 64500
tcgcagttag aacggttata gcatccacca tttatatcta aaaattagat caaagaatat 64560
gtgacaaagt cctagttgta tattgagaat tgacaaaaca atgtttctta catatttttt 64620
ttttattagt aaccgactta atagtaggaa ctggaaaact agacttgatt attctataag 64680
tatagatacc cttccaaata atattctctt tgataaaagt tccagaaaat gtagaatttt 64740
ttaaaaagtt atcttttgct attaccaaga ttgtgtttag acgcttatta ttaatatgag 64800
tgatgaaatc cacaccgcct ctagatatcg cctttatttc cacattagat ggtaaatcca 64860
atagtgaaac tatcttttta ggaatgtatg gactcgcgtt tagaggagtg aacgtcttgg 64920
gcgtcggaaa ggatgattcg tcaaacgaat aaacaatttc acaaatggat gttaatgtat 64980
tagtaggaaa ttttttgacg ctagtggaat tgaaaattct aatggatgat gttctaccta 65040
tttcatccga taacatgtta atttccgaca ccaacggttt taatatttcg atgatatacg 65100
gtagtctctc tttcggactt atatagctta ttccacaata cgagtcatta tatactccaa 65160
aaaacaaaat aactagtata aaatctgtat cgaatgggaa aaacgaaatt atcgacatag 65220
gtatagaatc cggaacattg aacgtattaa tacttaattc tttttctgtg gtaagtaccg 65280
ataggttatt gacattgtat ggttttaaat attctataac ttgagacttg atagatatta 65340
gtgatgaatt gaaaattatt tttatcacca cgtgtgtttc aggatcatcg tcgacgcccg 65400
tcaaccaacc gaacggagta aaataaatat cattaatata tgctctagat attagtattt 65460
ttatcaatcc tttgattatc atcttctcgt aggcgaatga ttccatgatc aagagtgatt 65520
taagaacatc ctccggagta ttaatgggct tagtaaacag tccatcgttg caataataaa 65580
agttatccaa gttaaaggat attatgcatt cgtttaaaga tatcacctca tctgacggag 65640
acaatttttt ggtaggtttt agagactttg aagctacttg tttaacaaag ttattcatcg 65700
tcgtttacta ttctatttaa ttttgtagtt aatttatcac atatcacatt aattgacttt 65760
ttggtccatt tttccatacg tttatattct tttaatcctg cgttatccgt ttccgttata 65820
tccagtgata gatcgtgcag gttaaataga atgctcttaa ataatgtcat ttttttatcc 65880
gctaaaaatt taaagaatgt ataaactttt ttcaaagatt taaaactttt aggtggtgtc 65940
ctagtacaca atatcataaa caaactaata aacatcccgc attcagattc caacagctga 66000
ttaacttcca cattaataca gcctattttc gctccaaatg tacattcgaa aaatctgaat 66060
aaaacatcaa tgtcgcaatt tgtattatcc aatacagaat gtttgtgatt cgtgttaaaa 66120
ccatcggaga aggaatagaa ataaaaatta ttatagtggt ggaattcagt tggaatattg 66180
cctccggagt cataaaagga tactaaacat tgttttttat cataaattac acatttccaa 66240
tgagacaaat aacaaaatcc aaacattaca aatctagagg tagaactttt aattttgtct 66300
ttaagtatat acgataagat atgtttattc ataaacgcgt caaatttttc atgaatcgct 66360
aaggagttta agaatctcat gtcaaattgt cctatataat ccacttcgga tccataagca 66420
aactgagaga ctaagttctt aatacttcga ttgctcatcc aggctcctct ctcaggctct 66480
attttcatct tgacgacctt tggattttca ccagtatgta ttcctttttt ttctagacac 66540
taaataaaat atttaaaata taatattaat gtactaaaac ttatatatta ttaatttatc 66600
taactaaagt tagtaaatta tatatataat tttataatta atttaatttt actaatttta 66660
tttagtgtct agaaaaaaa 66679
<210> 17
<211> 68308
<212> DNA
<213> Artificial Sequence
<220>
<223> sVAC fragment 2
<400> 17
tttttttcta gacactaaat aaaatattta aaatataata ttaatgtact aaaacttata 60
tattattaat ttatctaact aaagttagta aattatatat ataattttat aattaattta 120
attttactaa ttttatttag tgtctagaaa aaaaccccct gccattttag agattaatgc 180
gcatcgtttt aacgtgtcat agataccctc tatgctatca tcgatcatgt taagtagaaa 240
acagctagac atttggtgac gactagttcc cgcattaaat aaggtaggag aagcgtgcgt 300
aaaccatttt tcagaaagta gattgtacgt ctcaatagct gagtctatat cccattgatg 360
aattcctact gcgacacgca ttaacatgtg ctgaggtctt tcaacgatct tgttgtttat 420
tttcaacaag taggattttt ccaaagtttt aaaaccaaaa tagttgtatg aaaagtctcg 480
ttcgtaaata ataaccgagt tgagtttatc cttatatttg ttaactatat ccatggtgat 540
acttgaaata atcggagaat gtttcccatt tttaggatta acatagttga ataaatcctc 600
catcacttca ctaaatagtt tttttgtttc cttgtgtaga tttgatacgg ctattctggc 660
ggctagaatg gcataatccg gatgttgtgt agtacaagtg gctgctattt cggctgccag 720
agtgtccaat tctaccgttg ttactccatt atatattcct tgaataacct tcatagctat 780
tttaatagga tctatatgat ccgtgtttaa gccataacat aattttctaa tacgagacgt 840
gattttatca aacatgacat tttccttgta tccatttcgt ttaatgacaa acatttttgt 900
tggtgtaata aaaaaattat ttaacttttc attaataggg atttgacgta cgtagcgtac 960
aaaatgattg ttcctggtat atagataaag agtcctatat atttgaaaat cgttacggct 1020
cgattaaact ttaatgattg catagtgaat atatcattag gatttaactc cttgactatc 1080
agggcggcac cagaaattac catcaaaagc attaatacag ttatgcctat cgcagttaga 1140
acggttatag catccaccat ttatatctaa aaattagatc aaagaatatg tgacaaagtc 1200
ctagttgtat attgagaatt gacaaaacaa tgtttcttac atattttttt tttattagta 1260
accgacttaa tagtaggaac tggaaaacta gacttgatta ttctataagt atagataccc 1320
ttccaaataa tattctcttt gataaaagtt ccagaaaatg tagaattttt taaaaagtta 1380
tcttttgcta ttaccaagat tgtgtttaga cgcttattat taatatgagt gatgaaatcc 1440
acaccgcctc tagatatcgc ctttatttcc acattagatg gtaaatccaa tagtgaaact 1500
atctttttag gaatgtatgg actcgcgttt agaggagtga acgtcttggg cgtcggaaag 1560
gatgattcgt caaacgaata aacaatttca caaatggatg ttaatgtatt agtaggaaat 1620
tttttgacgc tagtggaatt gaaaattcta atggatgatg ttctacctat ttcatccgat 1680
aacatgttaa tttccgacac caacggtttt aatatttcga tgatatacgg tagtctctct 1740
ttcggactta tatagcttat tccacaatac gagtcattat atactccaaa aaacaaaata 1800
actagtataa aatctgtatc gaatgggaaa aacgaaatta tcgacatagg tatagaatcc 1860
ggaacattga acgtattaat acttaattct ttttctgtgg taagtaccga taggttattg 1920
acattgtatg gttttaaata ttctataact tgagacttga tagatattag tgatgaattg 1980
aaaattattt ttatcaccac gtgtgtttca ggatcatcgt cgacgcccgt caaccaaccg 2040
aacggagtaa aataaatatc attaatatat gctctagata ttagtatttt tatcaatcct 2100
ttgattatca tcttctcgta ggcgaatgat tccatgatca agagtgattt aagaacatcc 2160
tccggagtat taatgggctt agtaaacagt ccatcgttgc aataataaaa gttatccaag 2220
ttaaaggata ttatgcattc gtttaaagat atcacctcat ctgacggaga caattttttg 2280
gtaggtttta gagactttga agctacttgt ttaacaaagt tattcatcgt cgtttactat 2340
tctatttaat tttgtagtta atttatcaca tatcacatta attgactttt tggtccattt 2400
ttccatacgt ttatattctt ttaatcctgc gttatccgtt tccgttatat ccagtgatag 2460
atcgtgcagg ttaaatagaa tgctcttaaa taatgtcatt tttttatccg ctaaaaattt 2520
aaagaatgta taaacttttt tcaaagattt aaaactttta ggtggtgtcc tagtacacaa 2580
tatcataaac aaactaataa acatcccgca ttcagattcc aacagctgat taacttccac 2640
attaatacag cctattttcg ctccaaatgt acattcgaaa aatctgaata aaacatcaat 2700
gtcgcaattt gtattatcca atacagaatg tttgtgattc gtgttaaaac catcggagaa 2760
ggaatagaaa taaaaattat tatagtggtg gaattcagtt ggaatattgc ctccggagtc 2820
ataaaaggat actaaacatt gttttttatc ataaattaca catttccaat gagacaaata 2880
acaaaatcca aacattacaa atctagaggt agaactttta attttgtctt taagtatata 2940
cgataagata tgtttattca taaacgcgtc aaatttttca tgaatcgcta aggagtttaa 3000
gaatctcatg tcaaattgtc ctatataatc cacttcggat ccataagcaa actgagagac 3060
taagttctta atacttcgat tgctcatcca ggctcctctc tcaggctcta ttttcatctt 3120
gacgaccttt ggattttcac cagtatgtat tcctttacgt gataaatcat cgattttcaa 3180
atccatttgt gagaagtcta tcgccttaga tactttttcc cgtagtcgag gtttaaagaa 3240
atacgctaac ggtatactag taggtaactc aaaaacatca tatatagaat ggtaacgcgt 3300
ctttaactcg tcggttaact ctttcttttg atcgagttcg tcgctactat tgggtctgct 3360
caggtgcccc gactctacta gttccaacat cataccgata ggaatacaag acactttgcc 3420
ggcggttgta gatttatcat atttttccac tacatatccg ttacaatttg ttaaaaattt 3480
agatacatct atattgctac ataatccagc tagtgaatat atatgacata ataaattggt 3540
aaatcctagt tctggtattt tactaattac taaatctgta tatctttcca tttatcatgg 3600
aaaagaattt accagatatc ttcttttttc caaactgcgt taatgtattc tcttacaaat 3660
attcacaaga tgaattcagt aatatgagta aaacggaacg tgatagtttc tcattggccg 3720
tgtttccagt tataaaacat agatggcata acgcacacgt tgtaaaacat aaaggaatat 3780
acaaagttag tacagaagca cgtggaaaaa aagtatctcc tccatcacta ggaaaacccg 3840
cacacataaa cctaaccgcg aagcaatata tatacagtga acacacaata agctttgaat 3900
gttatagttt tctaaaatgt ataacaaata cagaaatcaa ttcgttcgat gagtatatat 3960
taagaggact attagaagct ggtaatagtt tacagatatt ttccaattcc gtaggtaaac 4020
gaacagatac tataggtgta ctagggaata agtatccatt tagcaaaatt ccattggcct 4080
cattaactcc taaagcacaa cgagagatat tttcagcgtg gatttctcat agacctgtag 4140
ttttaactgg aggaactgga gtgggtaaga cgtcacaggt acccaagtta ttgctttggt 4200
ttaattattt atttggtgga ttctctactc tagataaaat cactaacttt cacgaaagac 4260
cagtcattct atctcttcct aggatagctt tagttagatt gcatagcaat accattttaa 4320
aatcattggg atttaaggta ctagatggat ctcctatttc tttacggtac ggatctatac 4380
cggaagaatt aataaacaaa caaccaaaaa aatatggaat tgtattttct acccataagt 4440
tatctctaac aaaactattt agttatggca ctcttattat agacgaagtt catgagcatg 4500
atcaaatagg agatattatt atagcagtag cgagaaagca tcatacgaaa atagattcta 4560
tgtttttaat gactgccacg ttagaggatg accgagaacg gctaaaagta tttttaccta 4620
atcccgcatt tatacatatt cctggagata cactgtttaa aattagcgag gtatttattc 4680
ataataagat aaatccatct tccagaatgg catacataga agaagaaaag agaaatttag 4740
ttactgctat acagatgtat actcctcctg atggatcatc cggtatagtc tttgtggcat 4800
ccgttgcaca gtgtcacgaa tataaatcat atttagaaaa aagattaccg tatgatatgt 4860
atattattca tggtaaggtc ttagatatag acgaaatatt agaaaaagtg tattcatcac 4920
ctaatgtatc gataattatt tctactcctt atttggaatc cagcgttact atacgcaatg 4980
ttacacacat ttatgatatg ggtaaagttt ttgtccccgc tccttttgga ggatcgcaag 5040
aatttatttc taaatctatg agagatcaac gaaaaggaag agtaggaaga gttaatcctg 5100
gtacatacgt ctatttctat gatctgtctt atatgaagtc tatacagcga atagattcag 5160
aatttctaca taattatata ttgtacgcta ataagtttaa tctaacactc cccgaagatt 5220
tgtttataat ccctacaaat ttggatattc tatggcgtac aaaggaatat atagactcgt 5280
tcgatattag tacagaaaca tggaataaat tattatccaa ttattatatg aagatgatag 5340
agtatgctaa actttatgta ctaagtccta ttctcgctga ggagttggat aactttgaga 5400
ggacgggaga attaactagt attgtacgag aagccatttt atctctaaat ttacgaatta 5460
agattttaaa ttttaaacat aaagatgatg atacgtatat acacttttgt aaaatattat 5520
tcggtgtcta taacggaaca aacgctacta tatattatca tagacctcta acgggatata 5580
tgaatatgat ttcagatact atatttgttc ctgtagataa taactaaaaa tcaaactcta 5640
atgaccacat ctttttttag agatgaaaaa ttttctacat ctccttttgt agacacgact 5700
aaacattttg caaaaaaaag tttattagtg tttagataat cgtatacttc atcagtgtag 5760
atagtaaatg tgaacaaata aaaggtattc ttactcaata gattggtaaa ttccatagaa 5820
tatattaatc ctttcttctt gagatcccac atcatttcaa ccagagacgt tttatccaat 5880
gatttacctc gtactatacc acatacaaaa ctagattttg cagtgacgtc gtacctggta 5940
ttcctaccaa acaaaatttt acttttagtt cttttagaaa attctaaggt agaatctcta 6000
tttgccaata tgtcatctat ggaattacca ctagcaaaaa atgatagaaa tatatattga 6060
tacatcgcag ctggttttga tctactatac tttaaaaacg aatcagattc cataattgcc 6120
tgtatatcat cagctgaaaa actatgtttt acacgtattc cttcggcatt tctttttaat 6180
gatatatctt gtttagacaa tgataaagtt atcatgtcca tgagagacgc gtctccgtat 6240
cgtataaata tttcattaga tgttagacgc ttcattaggg gtatacttct ataaggtttc 6300
ttaatcagtc catcattggt tgcgtcaaga actactatcg gatgttgttg ggtatctcta 6360
gtgttacaca tggccttact aaagtttggg taaataacta tgatatctct attaattata 6420
gatgcatata tttcattcgt caaggatatt agtatcgact tgctatcgtc attaatacgt 6480
gtaatgtaat catataaatc atgcgatagc caaggaaaat tcaaatagat gttcatcata 6540
taatcgtcgc tataattcat attaatacgt tgacattgac taatttgtaa tatagcctcg 6600
ccacgaagaa agctctcgta ttcagtttca tcgataaagg ataccgttaa atataactgg 6660
ttgccgatag tctcatagtc tattaagtgg taagtttcgt acaaatacag aatccctaaa 6720
atattatcta atgttggatt aatctttacc ataactgtat aaaatggaga cggagtcata 6780
actattttac cgtttgtact tactggaata gacgaaggaa taatctccgg acatgctggt 6840
aaagacccaa atgtctgttt gaagaaatcc aatgttccag gtcctaatct cttaacaaaa 6900
attacgatat tcgatcccga tatcctttgc attctattta ccagcatatc acgaactata 6960
ttaagattat ctatcatgtc tattctccca ccgttatata aatcgcctcc gctaagaaac 7020
gttagtatat ccatacaatg gaatacttca tttctaaaat agtattcgtt ttctaattct 7080
ttaatgtgaa atcgtatact agaaagggaa aaattatctt tgagttttcc gttagaaaag 7140
aaccacgaaa ctaatgttct gattgcgtcc gattccgttg ctgaattaat ggatttacac 7200
caaaaactca tataacttct agatgtagaa gcattcgcta aaaaattagt agaatcaaag 7260
gatataagta gatgttccaa caagtgagca attcccaaga tttcatctat atcattctcg 7320
aatccgaaat tagaaattcc caagtagata tcctttttca tccgatcgtt gatgaaaata 7380
cgaactttat tcggtaagac aatcatttac taaggagtaa aataggaagt aatgttcgta 7440
tgtcgttatc atcgtataaa ttaaaggtgt gttttttacc attaagtgac attataattt 7500
taccaatatt ggaattataa tataggtgta tttgcgcact cgcgacggtt gatgcatcgg 7560
taaatatagc tgtatctaat gttctagtcg gtatttcatc atttcgctgt ctaataatag 7620
cgttttctct atctgtttcc attacagctg cctgaagttt attggtcgga taatatgtaa 7680
aataataaga aatacatacg aataacaaaa ataaaataag atataataaa gatgccattt 7740
agagatctaa ttttgttcaa cttgtccaaa ttcctactta cagaagatga ggaatcgttg 7800
gagatagtgt cttccttatg tagaggattt gaaatatctt atgatgactt gataacttac 7860
tttccagata ggaaatacca taaatatatt tctaaagtat ttgaacatgt agatttatcg 7920
gaggaattaa gtatggaatt ccatgataca actttgcgag atttagtcta tcttagattg 7980
tacaagtatt ccaagtgtat acggccgtgt tataaattag gagataatct aaaaggcata 8040
gttgttataa aggacaggaa tatttatatt agggaagcaa atgatgactt gatagaatat 8100
ctcctcaagg aatacactcc tcagatttat acatattcta atgagcgcgt ccccataact 8160
ggttcaaaat taattctttg tggattttct caagttacat ttatggcgta tacaacgtcg 8220
catataacaa caaataaaaa ggtagatgtt ctcgtttcca aaaaatgtat agatgaacta 8280
gtcgatccaa taaattatca aatacttcaa aatttatttg ataaaggaag cggaacaata 8340
aacaaaatac tcaggaagat attttattcg gtaacaggtg gccaaactcc ataggtagct 8400
ttttctattt cggattttag aatttccaaa ttcaccagcg atttatctgt tttggtgaaa 8460
tccaaggatt tattaatgtc cacaaatgcc atttgttttg tctgtggatt gtatttgaaa 8520
atggaaacga tgtagttaga tagatgcgct gcgaagtttc ctattagggt tccgcgcttc 8580
acgtcaccca gcatacttga atcaccatcc tttaaaaaaa atgataagat atcaacatgg 8640
agtatatcat actcggattt taattcttct actgcatcac tgacattttc acaaatacta 8700
caatacggtt taccgaaaat aatcagtacg ttcttcattt atgggtatca aaaacttaaa 8760
atcgttactg ctggaaaata aatcactgac gatattagat gataatttat acaaagtata 8820
caatggaata tttgtggata caatgagtat ttatatagcc gtcgccaatt gtgtcagaaa 8880
cttagaagag ttaactacgg tattcataaa atacgtaaac ggatgggtaa aaaagggagg 8940
gcatgtaacc ctttttatcg atagaggaag tataaaaatt aaacaagacg ttagagacaa 9000
gagacgtaaa tattctaaat taaccaagga cagaaaaatg ctagaattag aaaagtgtac 9060
atccgaaata caaaatgtta ccggatttat ggaagaagaa ataaaggcag aaatgcaatt 9120
aaaaatcgat aaactcacat ttcaaatata tttatctgat tctgataaca taaaaatatc 9180
attgaatgag atactaacac atttcaacaa taatgagaat gttacattat tttattgtga 9240
tgaacgagac gcagaattcg ttatgtgtct cgaggctaaa acacatttct ctaccacagg 9300
agaatggccg ttgataataa gtaccgatca ggatactatg ctatttgcat ctgctgataa 9360
tcatcctaag atgataaaaa acttaactca actgtttaaa tatgttccat ctgcagagga 9420
taactattta gcaaaattaa cggcgttagt gaatggatgt gatttctttc ctggactcta 9480
tggggcatct ataacaccca acaacttaaa caaaatacaa ttgtttagtg attttacaat 9540
cgataatata gtcactagtt tggcaattaa aaattattat agaaagacta actctaccgt 9600
agacgtgcgt aatattgtta cgtttataaa cgattacgct aatttagacg atgtctactc 9660
gtatattcct ccttgtcaat gcactgttca agaatttata ttttccgcat tagatgaaaa 9720
atggaatgaa tttaaatcat cttatttaga aagcgtgccg ttaccctgcc aattaatgta 9780
tgcgttagaa ccacgcaagg agattgatgt ttcagaagtt aaaactttat catcttatat 9840
agatttcgaa aatactaaat cagatatcga tgttataaaa tctatatcct cgatcttcgg 9900
atattctaac gaaaactgta acacgatagt attcggcatc tataaggata atttactact 9960
gagtataaat agttcatttt actttaacga tagtctgtta ataaccaata ctaaaagtga 10020
taatataata aatataggtt actagattaa aaatggtgtt ccaactcgtg tgctctacgt 10080
gcggcaaaga tatttctcac gaacgatata aattgattat acgaaaaaaa tcattaaagg 10140
atgtactcgt cagtgtaaag aacgaatgtt gtaggttaaa attatctaca caaatagaac 10200
ctcaacgtaa cttaacagtg caacctctat tggatataaa ctaatatgga tccggttaat 10260
tttatcaaga catatgcgcc tagaggttct attattttta ttaattatac catgtcatta 10320
acaagtcatt tgaatccatc gatagaaaaa catgtgggta tttattatgg tacgttatta 10380
tcggaacact tggtagttga atcaacatat agaaaaggag ttcgaatagt cccattggat 10440
agtttttttg aaggatatct tagtgcaaaa gtatacatgt tagagaatat tcaagttatg 10500
aaaatagcag ctgatacgtc attaacttta ttgggtattc cgtatggatt tggtcatgat 10560
agaatgtatt gttttaaatt ggtagctgac tgttataaaa atgccggtat tgatacatcg 10620
tctaaacgaa tattaggtaa agatattttt ctgagccaaa acttcacaga cgataataga 10680
tggataaaga tatatgattc taataattta acattttggc aaattgatta ccttaaaggg 10740
tgagttaata tgcataacta ctcctccgtt gttttttccc tcgttctttt tcttaacgtt 10800
gtttgccatc actctcataa tgtaaagata ttctaaaatg gtaaactttt gcatatcgga 10860
cgcagaaatt ggtataaatg ttgtaattgt attatttccc gtcaatggac tagtcacagc 10920
tccatcagtt ttatatcctt tagagtattt ctcactcgtg tctaacattc tagagcattc 10980
catgatctgt ttatcgttga tattggccgg aaagatagat tttttatttt ttattatatt 11040
actattggca attgtagata taacttctgg taaatatttt tctacctttt caatctcttc 11100
tattttcaag ccggctatat attctgctat attgttgcta gtatcaatac cttttctggc 11160
taagaagtca tatgtggtat tcactatatc agttttaact ggtagttcca ttagcctttc 11220
cacttctgca gaataatcag aaattggttc tttaccagaa aatccagcta ctataatagg 11280
ctcaccgatg atcattggca aaatcctata ttgtaccaga ttaatgagag catatttcat 11340
ttccaataat tctgctagtt cttgagacat tgatttattt gatgaatcta gttggttctc 11400
tagatactct accatttctg ccgcatacaa taacttgtta gataaaatca gggttatcaa 11460
agtgtttagc gtggctagaa tagtgggctt gcatgtatta aagaatgcgg tagtatgagt 11520
aaaccgtttt aacgaattat atagtctcca gaaatctgtg gcgttacata catgagccga 11580
atgacatcga agattgtcca atatttttaa tagctgctct ttgtccatta tttctatatt 11640
tgactcgcaa caattgtaga taccattaat caccgattcc tttttcgatg ccggacaata 11700
gcacaattgt ttagctttgg actctatgta ttcagaatta atagatatat ctcttaatac 11760
agattgcact atacattttg aaactatgtc aaaaattgta gaacgacgct gttctgcagc 11820
catttaactt taaataattt acaaaaattt aaaatgagca tccgtataaa aatcgataaa 11880
ctgcgccaaa ttgtggcata tttttcagag ttcagtgaag aagtatctat aaatgtagac 11940
tcgacggatg agttaatgta tatttttgcc gccttgggcg gatctgtaaa catttgggcc 12000
attatacctc tcagtgcatc agtgttctac cgcggagccg aaaatattgt gtttaatctt 12060
cctgtgtcca aggtaaaatc gtgtttgtgt agttttcaca atgatgccat catagatata 12120
gaacctgatc tggaaaataa tctagtaaaa ctttctagtt atcatgtagt aagtgtcgat 12180
tgtaataagg aactgatgcc tattaggaca gatactacta tttgtctaag tatagatcaa 12240
aagaaatctt acgtgtttaa ttttcacaag tatgaagaaa aatgttgtgg tagaaccgtc 12300
attcatttag aatggttgtt gggctttatc aagtgtatta gtcagcatca gcatttggct 12360
attatgttta aagatgacaa tattattatg aagactcctg gtaatactga tgcattttcc 12420
agggaatatt ctatgactga atgttctcaa gaactacaaa agttttcttt caaaatagct 12480
atctcgtctc tcaacaaact acgaggattc aaaaagagag tcaatgtttt tgaaactaga 12540
atcgtaatgg ataatgacga taacatttta ggaatgttgt tttcggatag agttcaatcc 12600
tttaagatca acatctttat ggcgttttta gattaatact ttcaatgaga taaatatggg 12660
tggcggagta agtgttgagc tccctaaacg ggatccgcct ccgggagtac ccactgatga 12720
gatgttatta aacgtggata aaatgcatga cgtgatagct cccgctaagc ttttagaata 12780
tgtgcatata ggaccactag caaaagataa agaggataaa gtaaagaaaa gatatccaga 12840
gtttagatta gtcaacacag gacccggtgg tctttcggca ttgttaagac aatcgtataa 12900
tggaaccgca cccaattgct gtcgcacttt taatcgtact cattattgga agaaggatgg 12960
aaagatatca gataagtatg aagagggtgc agtattagaa tcgtgttggc cagacgttca 13020
cgacaccgga aaatgcgatg ttgatttatt cgactggtgt cagggggata cgttcgatag 13080
aaacatatgc catcagtgga tcggttcagc ctttaatagg agtaatagaa ctgtagaggg 13140
tcaacaatcg ttaataaatc tgtataataa gatgcaaaca ttatgtagta aagatgctag 13200
tgtaccaata tgtgaatcat ttttgcatca tttacgcgca cacaatacag aagatagcaa 13260
agagatgatc gattatattc taagacaaca gtctgcggac tttaaacaga aatatatgag 13320
atgtagttat cccactagag ataagttaga agagtcatta aaatatgcgg aacctcgaga 13380
atgttgggat ccagagtgtt cgaatgccaa tgttaatttc ttgctaacac gtaattataa 13440
taatttagga ctttgcaata ttgtacgatg taatactagc gtgaacaact tacagatgga 13500
taaaacttcc tcattaagat tgtcatgtgg attaagcaat agtgatagat tttctactgt 13560
tcccgtcaat agagcaaaag tagttcaaca taatattaaa cactcgttcg acctaaaatt 13620
gcatttgatc agtttattat ctctcttggt aatatggata ctaattgtag ctatttaaat 13680
gggtgccgcg gcaagcatac agacgacggt gaatacactc agcgaacgta tctcgtctaa 13740
attagaacaa gaagcgaatg ctagtgctca aacaaaatgt gatatagaaa tcggaaattt 13800
ttatatccga caaaaccatg gatgtaacct cactgttaaa aatatgtgct ctgcggacgc 13860
ggatgctcag ttggatgctg tgttatcagc cgctacagaa acatatagtg gattaacacc 13920
ggaacaaaaa gcatacgtgc cagctatgtt tactgctgcg ttaaacattc agacgagtgt 13980
aaacactgtt gttagagatt ttgaaaatta tgtgaaacag acttgtaatt ctagcgcggt 14040
cgtcgataac aaattaaaga tacaaaacgt aatcatagat gaatgttacg gagccccagg 14100
atctccaaca aatttggaat ttattaatac aggatctagc aaaggaaatt gtgccattaa 14160
ggcgttgatg caattgacga ctaaggccac tactcaaata gcacctaaac aagttgctgg 14220
tacaggagtt cagttttata tgattgttat cggtgttata atattggcag cgttgtttat 14280
gtactatgcc aagcgtatgt tgttcacatc caccaatgat aaaatcaaac ttattttagc 14340
caataaggaa aacgtccatt ggactactta catggacaca ttctttagaa cttctccgat 14400
ggttattgct accacggata tgcaaaactg aaaatatatt gataatattt taatagatta 14460
acatggaagt tatcactgat cgtctagacg atatagtgaa acaaaatata gcggatgaaa 14520
aatttgtaga ttttgttata cacggtctag agcatcaatg tcctgctata cttcgaccat 14580
taattaggtt gtttattgat atactattat ttgttatagt aatttatatt tttacggtac 14640
gtctagtaag tagaaattat caaatgttgt tggcgttggt ggcgctagtc atcacattaa 14700
ctatttttta ttactttata ctataatagt actagactga cttctaacaa acatctcacc 14760
tgccataaat aaatgcttga tattaaagtc ttctatttct aacactattc catctgtgga 14820
aaataatact ctgacattat cgctaattga cacatcggtg agtgatatgc ctataaagta 14880
ataatcttct ttgggcacat ataccagtgt accaggttct aacaacctat ttactggtgc 14940
tcctatagca tactttttct ttaccttgag aatatccatc gtttgcttgg tcaatagcga 15000
tatgtgattt tttatcaacc actcgaaaaa gtaattggag tgttcatatc ctctacgggc 15060
tattgtctca tggccgtgta tgaaatttaa gtaacacgac tgtggtagat ttgttctata 15120
gagccggttg ccgcaaatag atagaactac caatatgtct gtacaaatgt taaacattaa 15180
ttgattaaca gaaaaaacaa tgttcgttct gggaatagaa accagatcaa aacaaaattc 15240
gttagaatat atgccacgtt tatacattga atataaaata actacagttt gaaaaataac 15300
agtatcattt aaacatttaa cttgcggggt taatctcaca actttactgt ttttgaactg 15360
ttcaaaatat agcatagatc cgtgagaaat acgtttagcc gcctttaata gaggaaatcc 15420
caccgccttt ctggatctca ccaacgacga tagttctgac cagcaactca tttcttcatc 15480
atccacctgt tttaacatat aataggcagg agatagatat ccgtcattgc aatattcctt 15540
ctcgtaggca cacaatctaa tattgataaa atctccattc tcttctctgc atttattatc 15600
ttgtttcggt ggctgattag gctgtagtct tggtttaggc tttggtatat cgttgttgaa 15660
tctattttgg tcattaaatc tttcatttct tcctggtata tttttatcac ctcgtttggt 15720
tggatttttg tctatattat cgtttgtaac atcggtacgg gtattcattt atcacaaaaa 15780
aaacttctct aaatgagtct actgctagaa aacctcatcg aagaagatac catatttttt 15840
gcaggaagta tatctgagta tgatgattta caaatggtta ttgccggcgc aaaatccaaa 15900
tttccaagat ctatgctttc tatttttaat atagtaccta gaacgatgtc aaaatatgag 15960
ttggagttga ttcataacga aaatatcaca ggagcaatgt ttaccacaat gtataatata 16020
agaaacaatt tgggtctagg agatgataaa ctaactattg aagccattga aaactatttc 16080
ttggatccta acaatgaagt tatgcctctt attattaata atacggatat gactgccgtc 16140
attcctaaaa aaagtggtag gagaaagaat aagaacatgg ttatcttccg tcaaggatca 16200
tcacctatct tgtgtatttt cgaaactcgt aaaaagatta atatttataa agaaaatatg 16260
gaatccgcgt cgactgagta tacacctatc ggagacaaca aggctttgat atctaaatat 16320
gcgggaatta atatcctaaa tgtgtattct ccttccacat ccataagatt gaatgccatt 16380
tacggattca ccaataaaaa taaactagag aaacttagta ctaataagga actagaatcg 16440
tatagttcta gccctcttca agaacccatt aggttaaatg attttctggg actattggaa 16500
tgtgttaaaa agaatattcc tctaacagat attccgacaa aggattgatt actataaatg 16560
gagaatgttc ctaatgtata ctttaatcct gtgtttatag agcccacgtt taaacattct 16620
ttattaagtg tttataaaca cagattaata gttttatttg aagtattcgt tgtattcatt 16680
ctaatatatg tattttttag atctgaatta aatatgttct tcatgcctaa acgaaaaata 16740
cccgatccta ttgatagatt acgacgtgct aatctagcgt gtgaagacga taaattaatg 16800
atctatggat taccatggat gacaactcaa acatctgcgt tatcaataaa tagtaaaccg 16860
atagtgtata aagattgtgc aaagcttttg cgatcaataa atggatcaca accagtatct 16920
cttaacgatg ttcttcgcag atgatgattc attttttaag tatttggcta gtcaagatga 16980
tgaatcttca ttatctgata tattgcaaat cactcaatat ctagactttc tgttattatt 17040
attgatccaa tcaaaaaata aattagaagc cgtgggtcat tgttatgaat ctctttcaga 17100
ggaatacaga caattgacaa aattcacaga ctttcaagat tttaaaaaac tgtttaacaa 17160
ggtccctatt gttacagatg gaagggtcaa acttaataaa ggatatttgt tcgactttgt 17220
gattagtttg atgcgattca aaaaagaatc ctctctagct accaccgcaa tagatcctgt 17280
tagatacata gatcctcgtc gcaatatcgc attttctaac gtgatggata tattaaagtc 17340
gaataaagtg aacaataatt aattctttat tgtcatcatg aacggcggac atattcagtt 17400
gataatcggc cccatgtttt caggtaaaag tacagaatta attagacgag ttagacgtta 17460
tcaaatagct caatataaat gcgtgactat aaaatattct aacgataata gatacggaac 17520
gggactatgg acgcatgata agaataattt tgaagcattg gaagcaacta aactatgtga 17580
tgtcttggaa tcaattacag atttctccgt gataggtatc gatgaaggac agttctttcc 17640
agacattgtt gaattctgtg agcgtatggc aaacgaagga aaaatagtta tagtagccgc 17700
actcgatggg acatttcaac gtaaaccgtt taataatatt ttgaatctta ttccattatc 17760
tgaaatggtg gtaaaactaa ctgctgtgtg tatgaaatgc tttaaggagg cttccttttc 17820
taaacgattg ggtgaggaaa ccgagataga aataatagga ggtaatgata tgtatcaatc 17880
ggtgtgtaga aagtgttaca tcgactcata atattatatt ttttatctaa aaaactaaaa 17940
ataaacattg attaaatttt aatataatac ttaaaaatgg atgttgtgtc gttagataaa 18000
ccgtttatgt attttgagga aattgataat gagttagatt acgaaccaga aagtgcaaat 18060
gaggtcgcaa aaaaactgcc gtatcaagga cagttaaaac tattactagg agaattattt 18120
tttcttagta agttacagcg acacggtata ttagatggtg ccaccgtagt gtatatagga 18180
tctgctcccg gtacacatat acgttatttg agagatcatt tctataattt aggagtgatc 18240
atcaaatgga tgctaattga cggccgccat catgatccta ttttaaatgg attgcgtgat 18300
gtgactctag tgactcggtt cgttgatgag gaatatctac gatccatcaa aaaacaactg 18360
catccttcta agattatttt aatttctgat gtgagatcca aacgaggagg aaatgaacct 18420
agtacggcgg atttactaag taattacgct ctacaaaatg tcatgattag tattttaaac 18480
cccgtggcgt ctagtcttaa atggagatgc ccgtttccag atcaatggat caaggacttt 18540
tatatcccac acggtaataa aatgttacaa ccttttgctc cttcatattc agctgaaatg 18600
agattattaa gtatttatac cggtgagaac atgagactga ctcgagttac caaatcagac 18660
gctgtaaatt atgaaaaaaa gatgtactac cttaataaga tcgtccgtaa caaagtagtt 18720
gttaactttg attatcctaa tcaggaatat gactattttc acatgtactt tatgctgagg 18780
accgtgtact gcaataaaac atttcctact actaaagcaa aggtactatt tctacaacaa 18840
tctatatttc gtttcttaaa tattccaaca acatcaactg aaaaagttag tcatgaacca 18900
atacaacgta aaatatctag caaaaattct atgtctaaaa acagaaatag caagagatcc 18960
gtacgcagta ataaatagaa acgtactact gagatatact accgatatag agtataatga 19020
tttagttact ttaataaccg ttagacataa aattgattct atgaaaactg tgtttcaggt 19080
atttaacgaa tcatccataa attatactcc ggttgatgat gattatggag aaccaatcat 19140
tataacatcg tatcttcaaa aaggtcataa caagtttcct gtaaattttc tatacataga 19200
tgtggtaata tctgacttat ttcctagctt tgttagacta gatactacag aaactaatat 19260
agttaatagt gtactacaaa caggcgatgg taaaaagact cttcgtcttc ccaaaatgtt 19320
agagacggaa atagttgtca agattctcta tcgccctaat ataccattaa aaattgttag 19380
atttttccgc aataacatgg taactggagt agagatagcc gatagatctg ttatttcagt 19440
cgctgattaa tcaattagta gagatgagat aagaacatta taataatcaa taatatatct 19500
tatatctcgt ttagaaaaat gctaatatta aaatagctaa cgctagtaat ccaatcggaa 19560
gccatttgat atctataata gggtatctaa tttcctgatt cagatagcgg acagctatat 19620
tctcggtagc tactcgtttg gaatcacaaa cattatttac atctaattta ctatctgtaa 19680
tggaaacgtt tcccaatgaa atggtacaat ccgatacatt gcattttgtt atattttttt 19740
ttaaagaggc tggtaacaac gcatcgcttc gtttacatgg ctcgtaccaa caataatagg 19800
gtaatcttgt atctattcct atccgtacta tgcttttatc aggataaata catttacatc 19860
gtatatcgtc tttgttagca tcacagaatg cataaatttg ttcgtccgtc atgataaaaa 19920
tttaaagtgt aaatataact attattttta tagttgtaat aaaaagggaa atttgattgt 19980
ataccttcgg ttctttaaaa gaaactgact tgataaaaat ggctgtaatc tctaaggtta 20040
cgtatagtct atatgatcaa aaagagatta atgctacaga tattatcatt agtcatgtta 20100
aaaatgacga cgatatcggt accgttaaag atggtagact aggtgctatg gatggggcat 20160
tatgtaagac ttgtgggaaa acggaattgg aatgtttcgg tcactggggt aaagtaagta 20220
tttataaaac tcatatagtt aagcctgaat ttatttcaga aattattcgt ttactgaatc 20280
atatatgtat tcactgcgga ttattgcgtt cacgagaacc gtattccgac gatattaacc 20340
taaaagagtt atcgggacac gctcttagga gattaaagga taaaatatta tccaagaaaa 20400
agtcatgttg gaacagtgaa tgtatgcaac cgtatcaaaa aattactttt tcaaagaaaa 20460
aggtttgttt cgtcaacaag ttggatgata ttaacgttcc taattctctc atctatcaaa 20520
agttaatttc tattcatgaa aagttttggc cattattaga aattcatcaa tatccagcta 20580
acttatttta tacagactac tttcccatcc ctccgttgat tattagaccg gctattagtt 20640
tttggataga tagtataccc aaagaaacca atgaattaac ttacttatta ggtatgatcg 20700
ttaagaattg taacttgaat gctgatgaac aggttatcca gaaggcggta atagaatacg 20760
atgatattaa aattatttct aataacactt ccagtatcaa tttatcatat attacatccg 20820
gcaaaaataa tatgattaga agttatatcg tcgcccgacg aaaagatcag acggctagat 20880
ctgtaattgg tcccagtaca tctatcaccg ttaatgaggt aggaatgccc gcatatatta 20940
gaaatacact tacagaaaag atatttgtta atgcctttac agtggataaa gttaaacaac 21000
tattagcatc aaaccaagtt aaattttact ttaataaacg attaaaccaa ttaacaagaa 21060
tacgccaagg aaagtttatc aaaaataaaa tacatttatt gcctggtgat tgggtagaag 21120
tagctgttca agaatataca agtattattt ttggaagaca gccgtctcta catagataca 21180
acgtcatcgc ttcatctatc agagctaccg aaggagatac tatcaaaata tctcccggaa 21240
ttgccaactc tcaaaatgct gatttcgacg gagatgaaga atggatgata ttagaacaaa 21300
atcctaaagc tgtaattgaa caaagtattc ttatgtatcc gacgacgtta ctcaaacacg 21360
atattcatgg agcccccgtt tatggatcta ttcaagatga aatcgtagca gcgtattcat 21420
tgtttaggat acaagatctt tgtttagatg aagtattgaa catcttgggg aaatatggaa 21480
gagagttcga tcctaaaggt aaatgtaaat tcagcggtaa agatatctat acttacttga 21540
taggtgaaaa gattaattat ccgggtctct taaaggatgg tgaaattatt gcaaacgacg 21600
tagatagtaa ttttgttgtg gctatgaggc atctgtcatt ggctggactc ttatccgatc 21660
ataagtcgaa cgtggaaggt atcaacttta ttatcaagtc atcttatgtt tttaagagat 21720
atctatctat ttacggtttt ggggtgacat tcaaagatct gagaccaaat tcgacgttca 21780
ctaataaatt ggaggccatc aacgtagaaa aaatagaact tatcaaagaa gcatacgcca 21840
aatatctcaa cgatgtaaga gacgggaaaa tagttccatt atctaaagct ttagaggcgg 21900
actatgtgga atccatgtta tccaacttga caaatcttaa tatccgagag atagaagaac 21960
atatgagaca aacgctgata gatgatccag ataataacct cctgaaaatg gccaaagcgg 22020
gttataaagt aaatcctaca gaactaatgt atattctagg tacgtatgga caacaaagga 22080
ttgatggtga accagcagag actcgagtat tgggtagagt cttaccttac tatcttccag 22140
actctaagga tccagaagga agaggttaca ttcttaattc tttaacaaaa ggattaacag 22200
gttctcaata ttacttttcg atgctggttg caagatctca atctactgat atcgtctgtg 22260
aaacatcacg taccggaaca ctggctagaa aaatcattaa aaagatggag gatatggtgg 22320
tcgacggata cggacaagta gttataggta atacgctcat caagtacgcc gccaattata 22380
ccaaaattct aggctcagta tgtaaacctg tagatcttat ctatccagat gagtccatga 22440
cttggtattt ggaaattagt gctctgtgga ataaaataaa acagggattc gtttactctc 22500
agaaacagaa acttgcaaag aagacattgg cgccgtttaa tttcctagta ttcgtcaaac 22560
ccaccactga ggataatgct attaaggtta aggatctgta cgatatgatt cataacgtca 22620
ttgatgatgt gagagagaaa tacttcttta cggtatctaa tatagatttt atggagtata 22680
tattcttgac gcatcttaat ccttctagaa ttagaattac aaaagaaacg gctatcacta 22740
tctttgaaaa gttctatgaa aaactcaatt atactctagg tggtggaact cctattggaa 22800
ttatttctgc acaggtattg tctgagaagt ttacacaaca agccctgtcc agttttcaca 22860
ctactgaaaa aagtggtgcc gtcaaacaaa aacttggttt caacgagttt aataacttga 22920
ctaatttgag taagaataag accgaaatta tcactctggt atccgatgat atctctaaac 22980
ttcaatctgt taagattaat ttcgaatttg tatgtttggg agaattaaat ccagacatca 23040
ctcttcgaaa agaaacagat aggtatgtag tagatataat agtcaataga ttatacatca 23100
agagagcaga aattaccgaa ttagtcgtcg aatatatgat tgaacgattc atctccttta 23160
gcgtcattgt aaaggaatgg ggtatggaaa cattcattga ggacgaggat aatattagat 23220
ttactgtcta tctaaatttc gttgaaccag aggaattgaa tcttagtaag tttatgatgg 23280
ttcttccggg ggcagccaac aagggaaaga ttagtaaatt caagattcct atctctgatt 23340
atacgggtta tgacgacttc aatcaaacaa aaaagctcaa taagatgact gtagaactca 23400
tgaatctaaa agaattaggt tctttcgatt tggaaaacgt caacgtgtat cctggagtat 23460
ggaatacata cgatatcttc ggtatcgagg ccgctcgtga atacttgtgc gaagccatgt 23520
taaacaccta tggagaaggg ttcgattatc tgtatcagcc ttgtgatctt ctcgctagtt 23580
tactatgtgc tagttacgaa ccagaatcag tgaataaatt caagttcggc gcagctagta 23640
ctcttaagag agctacgttc ggagacaata aagcattgtt aaacgcggct cttcataaaa 23700
agtcagaacc tattaacgat aatagtagct gccacttttt tagcaaggtc cctaatatag 23760
gaactggata ttacaaatac tttatcgact tgggtcttct catgagaatg gaaaggaaac 23820
tatctgataa gatatcttct caaaagatca aggaaatgga agaaacagaa gacttttaat 23880
tcttatcaat aacatatttt tctatgatct gtcttttaaa cgatggattt tccacaaatg 23940
cgcctctcaa gtccctcata gaatgataca cgtataaaaa atatagcata ggcaatgact 24000
ccttattttt agacattaga tatgccaaaa tcatagcccc gcttctattt actcccgcag 24060
cacaatgaac caacacgggc tcgtttcgtt gatcacattt agataaaaag gcggttacgt 24120
cgtcaaaata tttactaata tcggtagttg tatcatctac caacggtata tgaataatat 24180
taatattaga gttaggtaat gtatatttat ccatcgtcaa atttaaaaca tatttgaact 24240
taacttcaga tgatggtgca tccatagcat ttttataatt tcccaaatac acattattgg 24300
ttacccttgt cattatagtg ggagatttgg ctctgtgcat atctccagtt gaacgtagta 24360
gtaagtattt atacaaactt ttcttatcca tttataacgt acaaatggat aaaactactt 24420
tatcggtaaa cgcgtgtaat ttagaatacg ttagagaaaa ggctatagta ggcgtacaag 24480
cagccaaaac atcaacactt atattctttg ttattatatt ggcaattagt gcgctattac 24540
tctggtttca gacgtctgat aatccagtct ttaatgaatt aacgagatat atgcgaatta 24600
aaaatacggt taacgattgg aaatcattaa cggatagcaa aacaaaatta gaaagtgata 24660
gaggtagact tctagccgct ggtaaggatg atatattcga attcaaatgt gtggatttcg 24720
gcgcctattt tatagctatg cgattggata agaaaacata tctgccgcaa gctattaggc 24780
gaggtactgg agacgcgtgg atggttaaaa aggcggcaaa ggtcgatcca tctgctcaac 24840
aattttgtca gtatttgata aaacacaagt ctaataatgt tattacttgt ggtaatgaga 24900
tgttaaatga attaggttat agcggttatt ttatgtcacc gcattggtgt tccgatttta 24960
gtaatatgga atagtgttag ataaatgcgg taacgaatgt tcctgtaagg aaccataaca 25020
gtttagattt aacgttaaag atgagcataa acataataaa caaaattaca atcaaaccta 25080
taacattaat atcaaacaat ccaaaaaatg aaatcagtgg agtagtaaac gcgtacataa 25140
ctcctggata acgtttagta gctgccgttc ctattctaga ccaaaaattc ggtttcatgt 25200
tttcgaaacg gtgttctgca acaagtcggg gatcgtgttc tacatatttg gcggcattat 25260
ccagtatctg cctattgatc ttcatttcgt tttcaattct ggctatttca aaataaaatc 25320
ccgatgatag acctccagac tttataattt catctacgat gttcagcgcc gtagtaactc 25380
taataatata ggctgataag ctaacatcat accctcctgt atatgtgaat atggcatgat 25440
ttttgtccat tacaagctcg gttttaactt tattgcctgt aataatttct ctcatctgta 25500
ggatatctat ttttttgtca tgcattgcct tcaagacggg acgaagaaac gtaatatcct 25560
caataacgtt atcgttttct acaataacta catattctac ctttttattt tctaactcgg 25620
taaaaaaatt agaatcccat agggctaaat gtctagcgat atttcttttc gtttcctctg 25680
tacacatagt gttacaaaac cctgaaaaga agtgagtata cttgtcatca tttctaatgt 25740
ttcctccagt ccactgtata aacgcataat ccttgtaatg atctggatca tccttgacta 25800
ccacaacatt tcttttttct ggcataactt cgttgtcctt tacatcatcg aacttctgat 25860
cattaatatg ctcatgaaca ttaggaaatg tttctgatgg aagtctatca ataactggca 25920
caacaataac aggagttttc gccgccgcca tttagttatt gaaattaatc atatacaact 25980
ctttaatacg agttatattt tcgtctatcc attgtttcac atttacatat ttcgacaaaa 26040
agatataaaa tgcgtattcc aatgcttctc tgtttaatga attactaaaa tatacaaaca 26100
cgtcactgtc tggcaataaa tgatatctta gaatattgta acaatttatt ttgtattgca 26160
catgttcgtg atctatgagt tcttcttcga atggcatagg atctccgaat ctgaaaacgt 26220
ataaatagga gttagaataa taatatttga gagtattggt aatatataaa ctctttagcg 26280
gtataattag tttttttctc tcaatttcta tttttagatg tgatggaaaa atgactaatt 26340
ttgtagcatt agtatcatga actctaatca aaatcttaat atcttcgtca cacgttagct 26400
ctttgaagtt tttaagagat gcatcagttg gttcgaccga tggagtaggt gcaacaattt 26460
tttgttcgat gtatgtatgt actggagcca ttgttttaac tataatggtg cttgtatcga 26520
aaaactttaa tgcagatagc ggaagctctt cgccgcgact ttctacatcg taattgggtt 26580
ctaacgccga tctctgaatg gatactagtt ttctaagttc taatgtgatt ctctgaaaat 26640
gtaaatccaa ttcctccggc attatagatg tgtatacatc ggtaaataaa actatagtat 26700
ccaacgatcc cttctcgcaa attctagtct taaccaaaaa atcgtatata accacggaga 26760
tggcgtattt aagagtggat tcttctaccg ttttgttctt ggatgtcata taggaaacta 26820
taaagtccgc actactgtta agaatgatta ctaacgcaac tatatagttc aaattaagca 26880
ttttggaaac ataaaataac tctgtagacg atacttgact ttcgaataag tttgcagaca 26940
aacgaagaaa gaacagacct ctcttaattt cagaagaaaa ctttttttcg tattcctgac 27000
gtctagagtt tatatcaata agaaagttaa gaattagtcg gttaatgttg tatttcatta 27060
cccaagtttg agatttcata atattatcaa aagacatgat aatattaaag ataaagcgct 27120
gactatgaac gaaatagcta tatggttcgc tcaaaaatat agtcttgtta aacgtggaaa 27180
cgataactgt atttttaatc acgtcagcgg catctaaatt aaatataggt atatttattc 27240
cacacactct acaatatgcc acaccatctt cataataaat aaattcgtta gcaaaattat 27300
taattttagt gaaatagtta gcgtcaactt tcatagcttc cttcaatcta atttgatgct 27360
cacacggtgc gaattccact ctaacatccc ttttccatgc ctcaggttca tcgatctcta 27420
taatatctag ttttttgcgt ttcacaaaca caggctcgtc tctcgcgatg agatctgtat 27480
agtaactatg taaatgataa ctagatagaa agatgtagct atatagatga cgatccttta 27540
agagaggtat aataacttta ccccaatcag atagactgtt gttatggtct tcggaaaaag 27600
aatttttata aatttttcca gtattttcca aatatacgta cttaacatct aaaaaatcct 27660
taatgataat aggaatggat aatccgtcta ttttataaag aaatacatat cgcacattat 27720
actttttttt ggaaatggga ataccgatgt gtctacataa atatgcaaag tctaaatatt 27780
ttttagagaa tcttaattgg tccaaattct tttccaagta cggtaataga tttttcatat 27840
tgaacggtat cttcttaatc tctggttcta gttccgcatt aaatgatgaa actaagtcac 27900
tatttttata actaacgatt acatcacctc taacatcatc atttaccaga atactgatct 27960
tcttttgtcg taaatacatg tctaatgtgt taaaaaaaag atcatacaag ttatacgtca 28020
tttcatctgt ggtattcttg tcattgaagg ataaactcgt actaatctct tctttaacag 28080
cctgttcaaa tttatatcct atatacgaaa aaatagcaac cagtgtttga tcatccgcgt 28140
caatattctg ttctatcgta gtgtataaca atcgtatatc ttcttctgtg atagtcgata 28200
cgttataaag gttgataacg aaaatatttt tatttcgtga aataaagtca tcgtaggatt 28260
ttggacttat attcgcgtct agtagatatg cttttatttt tggaatgatc tcaattagaa 28320
tagtctcttt agagtccatt taaagttaca aacaactagg aaattggttt atgatgtata 28380
atttttttag tttttataga ttctttattc tatacttaaa aaatgaaaat aaatacaaag 28440
gttcttgagg gttgtgttaa attgaaagcg agaaataatc ataaattatt tcattatcgc 28500
gatatccgtt aagtttgtat cgtaatggcg tggtcaatta caaataaagc ggatactagt 28560
agcttcacaa agatggctga aatcagagct catctaaaaa atagcgctga aaataaagat 28620
aaaaacgagg atattttccc ggaagatgta ataattccat ctactaagcc caaaaccaaa 28680
cgagccacta ctcctcgtaa accagcggct actaaaagat caaccaaaaa ggaggaagtg 28740
gaagaagaag tagttataga ggaatatcat caaacaactg aaaaaaattc tccatctcct 28800
ggagtcagcg acattgtaga aagcgtggcc gctgtagagc tcgatgatag cgacggggat 28860
gatgaaccta tggtacaagt tgaagctggt aaagtaaatc atagtgctag aagcgatctc 28920
tctgacctaa aggtggctac cgacaatatc gttaaagatc ttaagaaaat tattactaga 28980
atctctgcag tatcgacggt tctagaggat gttcaagcag ctggtatctc tagacaattt 29040
acttctatga ctaaagctat tacaacacta tctgatctag tcaccgaggg aaaatctaaa 29100
gttgttcgta aaaaagttaa aacttgtaag aagtaaatgc gtgcactttt ttataaagat 29160
ggtaaactct ttaccgataa taatttttta aatcctgtat cagacgataa tccagcgtat 29220
gaggttttgc aacatgttaa aattcctact catttaacag atgtagtagt atatgaacaa 29280
acgtgggagg aggcgttaac tagattaatt tttgtgggaa gtgattcaaa aggacgtaga 29340
caatactttt acggaaaaat gcatgtacag aatcgcaacg ctaaaagaga tcgtattttt 29400
gttagagtat ataacgttat gaaacgaatt aattgtttta taaacaaaaa tataaagaaa 29460
tcgtccacag attccaatta tcagttggcg gtttttatgt taatggaaac tatgtttttt 29520
attagatttg gtaaaatgaa atatcttaag gagaatgaaa cagtagggtt attaacacta 29580
aaaaataaac acatagaaat aagtcccgat gaaatagtta tcaagtttgt aggaaaggac 29640
aaagtttcac atgaatttgt tgttcataag tctaatagac tatataagcc gctattgaaa 29700
ctgacggatg attctagtcc cgaagaattt ctgttcaaca aactaagtga acgaaaggta 29760
tatgaatgta tcaaacagtt tggtattaga atcaaggatc tccgaacgta tggagtcaat 29820
tatacgtttt tatataattt ttggacaaat gtaaagtcca tatctcctct tccatcacca 29880
aaaaagttaa tagcgttaac tatcaaacaa actgctgaag tggtaggtca tactccatca 29940
atttcaaaaa gagcttatat ggcaacgact attttagaaa tggtaaagga taaaaatttt 30000
ttagatgtag tatctaaaac tacgttcgat gaattcctat ctatagtcgt agatcacgtt 30060
aaatcatcta cggatggatg atatagatct ttacacaaat aattacaaaa ccgataaatg 30120
gaaatggata agcgtatgaa atctctcgca atgaccgctt tctttgggga gctaagcaca 30180
ttagatatta tggcattgat aatgtctata tttaaacgcc atccaaacaa taccattttt 30240
tcagtggata aggatggtca gtttatgatt gatttcgaat acgataatta taaggcttct 30300
caatatttgg atctgaccct cactccgata tctggagatg aatgcaagac tcacgcatcg 30360
agtatagccg aacaattggc gtgtgtggat attattaaag aggatattag cgaatatatc 30420
aaaactactc cccgtcttaa acgatttata aaaaaatacc gcaatagatc agatactcgc 30480
atcagtcgag atacagaaaa gcttaaaata gctctagcta aaggcataga ttacgaatat 30540
ataaaagacg cttgttaata agtaaatgaa aaaaaactag tcgtttataa taaaacacga 30600
tatggatgcc aacgtagtat catcttctac tattgcgacg tatatagacg ctttagcgaa 30660
gaatgcttcg gaattagaac agaggtctac cgcatacgaa ataaataatg aattggaact 30720
agtatttatt aagccgccat tgattacttt gacaaatgta gtgaatatct ctacgattca 30780
ggaatcgttt attcgattta ccgttactaa taaggaaggt gttaaaatta gaactaagat 30840
tccattatct aaggtacatg gtctagatgt aaaaaatgta cagttagtag atgctataga 30900
taacatagtt tgggaaaaga aatcattagt gacggaaaat cgtcttcaca aagaatgctt 30960
gttgagacta tcgacagagg aacgtcatat atttttggat tacaagaaat atggatcctc 31020
tatccgacta gaattagtca atcttattca agcaaaaaca aaaaacttta cgatagactt 31080
taagctaaaa tattttctag gatccggtgc ccagtctaaa agttctttat tacacgctat 31140
taatcatcca aagtcaaggc ctaatacatc tctggaaata gaatttacac ctagagacaa 31200
tgaaacagtt ccatatgatg aactaataaa ggaattgacg actctctcgc gtcatatatt 31260
tatggcttct ccagagaatg taattctttc tccgcctatt aacgcgccta taaaaacctt 31320
tatgttgcct aaacaagata tagtaggttt ggatctggaa aatctatatg ccgtaactaa 31380
gactgacggc attcctataa ctatcagagt tacatcaaac gggttgtatt gttattttac 31440
acatcttggt tatattatta gatatcctgt taagagaata atagattccg aagtagtagt 31500
ctttggtgag gcagttaagg ataagaactg gaccgtatat ctcattaagc taatagagcc 31560
tgtgaatgca atcaatgata gactagaaga aagtaagtat gttgaatcta aactagtgga 31620
tatttgtgat cggatagtat tcaagtcaaa gaaatacgaa ggtccgttta ctacaactag 31680
tgaagtcgtc gatatgttat ctacatattt accaaagcaa ccagaaggtg ttattctgtt 31740
ctattcaaag ggacctaaat ctaacattga ttttaaaatt aaaaaggaaa atactataga 31800
ccaaactgca aatgtagtat ttaggtacat gtccagtgaa ccaattatct ttggagagtc 31860
gtctatcttt gtagagtata agaaatttag caacgataaa ggctttccta aagaatatgg 31920
ttctggtaag attgtgttat ataacggcgt taattatcta aataatatct attgtttgga 31980
atatattaat acacataatg aagtgggtat taagtccgtg gttgtaccta ttaagtttat 32040
agcagaattc ttagttaatg gagaaatact taaacctaga attgataaaa ccatgaaata 32100
tattaactca gaagattatt atggaaatca acataatatc atagtcgaac atttaagaga 32160
tcaaagcatc aaaataggag atatctttaa cgaggataaa ctatcggatg tgggacatca 32220
atacgccaat aatgataaat ttagattaaa tccagaagtt agttatttta cgaataaacg 32280
aactagagga ccgttgggaa ttttatcaaa ctacgtcaag actcttctta tttctatgta 32340
ttgttccaaa acatttttag acgattccaa caaacgaaag gtattggcga ttgattttgg 32400
aaacggtgct gacctggaaa aatactttta tggagagatt gcgttattgg tagcgacgga 32460
tccggatgct gatgctatag ctagaggaaa tgaaagatac aacaaattaa actctggaat 32520
taaaaccaag tactacaaat ttgactacat tcaggaaact attcgatccg atacatttgt 32580
ctctagtgtc agagaagtat tctattttgg aaagtttaat atcatcgact ggcagtttgc 32640
tatccattat tcttttcatc cgagacatta tgctaccgtc atgaataact tatccgaact 32700
aactgcttct ggaggcaagg tattaatcac taccatggac ggagacaaat tatcaaaatt 32760
aacagataaa aagactttta taattcataa gaatttacct agtagcgaaa actatatgtc 32820
tgtagaaaaa atagctgatg atagaatagt ggtatataat ccatcaacaa tgtctactcc 32880
aatgactgaa tacattatca aaaagaacga tatagtcaga gtgtttaacg aatacggatt 32940
tgttcttgta gataacgttg atttcgctac aattatagaa cgaagtaaaa agtttattaa 33000
tggcgcatct acaatggaag atagaccatc tacaagaaac tttttcgaac taaatagagg 33060
agccattaaa tgtgaaggtt tagatgtcga agacttactt agttactatg ttgtttatgt 33120
cttttctaag cggtaaataa taatatggta tgggttctga tctcccagtt ctaaatgcat 33180
taaataattc caatagagcg atttttgttc ctataggacc ttccaactgt ggatactctg 33240
tattgttaat agatatatta atacttttgt cgggtaacag aggttctacg tcttttaaaa 33300
ataaaagttt gataacatct ggcctgttca taaataaaaa cttggcgatt ctatatatac 33360
tcttattatc aaatctagcc attgtcttat agatgtgagc tactgtaggt gtaccatttg 33420
attttctttc taatactata tatttctctc gaagaagttc ttgcacatca tctgggaata 33480
aaatactact gttgagtaaa tcagttattt tttttatatc gatattgatg gacattttta 33540
tagttaagga taataagtat cccaaagtag ataacgacga taacgaagta tttatacttt 33600
taggaaatca caatgacttt atcagattaa aattaacaaa attaaaggag catgtatttt 33660
tttctgaata tattgtgact ccagatacat atggatcttt atgcgtcgaa ttaaatgggt 33720
ctagttttca gcacggcggt agatatatag aggtggagga atttatagat gctggaagac 33780
aagttagatg gtgttctaca tccaatcata tatctaaaga tatacccgaa gatatgcaca 33840
ctgataaatt tgtcatttat gatatataca cttttgacgc tttcaagaat aaacgattgg 33900
tattcgtaca ggtacctccg tcgttaggag atgatagtca tttgactaat ccgttattgt 33960
ctccgtatta tcgtaattca gtagccagac aaatggtcaa tgatatgatt tttaatcaag 34020
attcattttt aaaatattta ttagaacatc tgattagaag ccactataga gtttctaaac 34080
atataacaat agttagatac aaggataccg aagaattaaa tctaacgaga atatgttata 34140
atagagataa gtttaaggcg tttgtattcg cttggtttaa cggcgtttcg gaaaatgaaa 34200
aggtactaga tacgtataaa aaggtatcta atttgatata atgaattcag tgactgtatc 34260
acacgcgcca tatactatta cttatcacga tgattgggaa ccagtaatga gtcaattggt 34320
agagttttat aacgaagtag ccagttggct gctacgagac gagacgtcgc ctattcctga 34380
taagttcttt atacagttga aacaaccgct tagaaataaa cgagtatgtg tgtgcggtat 34440
agatccgtat ccgaaagatg gaactggtgt accgttcgaa tcaccaaatt ttacaaaaaa 34500
atcaattaag gagatagctt catctatatc tagattaacc ggagtaattg attataaagg 34560
ttataacctt aatataatag acggggttat accctggaat tattacttaa gttgtaaatt 34620
aggagaaaca aaaagtcacg cgatctactg ggataagatt tccaagttac tgctgcagca 34680
tataactaaa cacgttagtg ttctttattg tttgggtaaa acagatttct cgaatatacg 34740
ggccaagtta gaatccccgg taactaccat agtcggatat catccagcgg ctagagaccg 34800
ccaattcgag aaagatagat catttgaaat tatcaacgtt ttactggaat tagacaacaa 34860
ggcacctata aattgggctc aagggtttat ttattaatgc tttagtgaaa ttttaacttg 34920
tgttctaaat ggatgcggct attagaggta atgatgttat ctttgttctt aagactatag 34980
gtgtcccgtc agcgtgcaga caaaatgaag atccaagatt tgtagaagca tttaaatgcg 35040
acgagttaga aagatatatt gagaataatc cagaatgtac actattcgaa agtcttaggg 35100
atgaggaagc atactctata gtcagaattt tcatggatgt agatttagac gcgtgtctag 35160
acgaaataga ttatttaacg gctattcaag attttattat cgaggtgtca aactgtgtag 35220
ctagattcgc gtttacagaa tgcggcgcca ttcatgaaaa tgtaataaaa tccatgagat 35280
ctaatttttc attgactaag tctacaaata gagataaaac aagttttcat attatctttt 35340
tagacacgta taccactatg gatacattga tagctatgaa acgaacacta ttagaattaa 35400
gtagatcatc tgaaaatcca ctaacaagat cgatagacac tgccgtatat aggagaaaaa 35460
caactcttcg ggttgtaggt actaggaaaa atccaaattg cgacactatt catgtaatgc 35520
aaccaccgca tgataatata gaagattacc tattcactta cgtggatatg aacaacaata 35580
gttattactt ttctctacaa caacgattgg aggatttagt tcctgataag ttatgggaac 35640
cagggtttat ttcattcgaa gacgctataa aaagagtttc aaaaatattc attaattcta 35700
taataaactt taatgatctc gatgaaaata attttacaac ggtaccactg gtcatagatt 35760
acgtaacacc ttgtgcatta tgtaaaaaac gatcgcataa acatccgcat caactatcgt 35820
tggaaaatgg tgctattaga atttacaaaa ctggtaatcc acatagttgt aaagttaaaa 35880
ttgttccgtt ggatggtaat aaactgttta atattgcaca aagaatttta gacactaact 35940
ctgttttatt aaccgaacga ggagaccata tagtttggat taataattca tggaaattta 36000
acagcgaaga acccttgata acaaaactaa ttttgtcaat aagacatcaa ctacctaagg 36060
aatattcaag cgaattactc tgtccaagaa aacgaaagac tgtagaagct aacatacgag 36120
acatgttagt agattcagta gagaccgata cctatccgga taaacttccg tttaaaaatg 36180
gtgtattgga cctggtagac ggaatgtttt actctggaga tgatgctaaa aaatatacgt 36240
gtactgtatc aaccggattt aaatttgacg atacaaagtt cgtcgaagac agtccagaaa 36300
tggaagagtt aatgaatatc attaacgata tccaaccatt aacggatgaa aataagaaaa 36360
atagagagct atatgaaaaa acattatcta gttgtttatg cggtgctacc aaaggatgtt 36420
taacattctt ttttggagaa actgcaactg gaaagtcgac aaccaaacgt ttgttaaagt 36480
ctgctatcgg tgacctgttt gttgagacgg gtcaaacaat tttaacagat gtattggata 36540
aaggacctaa tccatttatc gctaacatgc atttgaaaag atctgtattc tgtagcgaac 36600
tacctgattt tgcctgtagt ggatcaaaga aaattagatc tgacaatatt aaaaagttga 36660
cagaaccttg tgtcattgga agaccgtgtt tctccaataa aattaataat agaaaccatg 36720
cgacaatcat tatcgatact aattacaaac ctgtttttga taggatagat aacgcattaa 36780
tgagaagaat tgccgtcgtg cgattcagaa cacacttttc tcaaccttct ggtagagagg 36840
ctgctgaaaa taatgacgcg tacgataaag tcaaactatt agacgagggg ttagatggta 36900
aaatacaaaa taatagatat agattcgcat ttctatactt gttggtgaaa tggtacagaa 36960
aatatcatgt tcctattatg aaactatatc ctacacccga agagattcct gactttgcat 37020
tctatctcaa aataggtact ctgttagtat ctagctctgt aaagcatatt ccattaatga 37080
cggacctctc caaaaaggga tatatattgt acgataatgt ggtcactctt ccgttgacta 37140
ctttccaaca gaaaatatcc aagtatttta attctagact atttggacac gatatagaga 37200
gcttcatcaa tagacataag aaatttgcca atgttagtga tgaatatctg caatatatat 37260
tcatagagga tatttcatct ccgtaaatat atgctcatat atttatagaa gatatcacat 37320
atctaaatga ataccggaat catagattta tttgataatc atgttgatag tataccaact 37380
atattacctc atcagttagc tactctagat tatctagtta gaactatcat agatgagaac 37440
agaagcgtgt tattgttcca tattatggga tcaggtaaaa caataatcgc tttgttgttc 37500
gccttggtag cttccagatt taaaaaggtt tacattctag tgcctaatat caacattttg 37560
aaaattttta attataatat gggtgtagct atgaacttgt ttaatgacga attcatagct 37620
gagaatatct ttattcattc cacaacaagt ttttattctc ttaattataa cgataacgtc 37680
attaattata acggattatc tcgctacaat aactctattt ttatcgttga tgaggcacat 37740
aatatctttg ggaataatac tggagaactt atgaccgtga taaaaaataa aaacaagatt 37800
ccttttctac tattgtctgg atctcccatt actaacacac ctaatactct gggtcatatt 37860
atagatttaa tgtccgaaga gacgatagat tttggtgaga ttattagtcg tggtaagaaa 37920
gtaattcaga cacttcttaa cgaacgcggt gtgaatgtac ttaaggattt gcttaaagga 37980
agaatatcat attacgaaat gcctgataaa gatctaccaa cgataagata tcacggacgt 38040
aagtttctag atactagagt agtatattgt cacatgtcta aacttcaaga gagagattat 38100
atgattacta gacgacagct atgttatcat gaaatgtttg ataaaaatat gtataacgtg 38160
tcaatggcag tattgggaca acttaatctg atgaataatt tagatacttt atttcaggaa 38220
caggataagg aattgtaccc aaatctgaaa ataaataatg gcgtgttata cggagaagaa 38280
ttggtaacgt taaacattag ttccaaattt aaatacttta ttaatcggat acagacactc 38340
aacggaaaac attttatata cttttctaat tctacatatg gcggattggt aattaaatat 38400
atcatgctca gtaatggata ttctgaatat aatggttctc agggaactaa tccacatatg 38460
ataaacggca aaccaaaaac atttgctatc gttactagta aaatgaaatc gtctttagag 38520
gatctattag atgtgtataa ttctcctgaa aacgatgatg gtagtcaatt gatgtttttg 38580
ttttcgtcaa acattatgtc cgaatcctat actctgaaag aggtaaggca tatttggttt 38640
atgactatcc cagatacttt ttctcaatac aaccaaattc ttggacgatc tattagaaaa 38700
ttctcttacg ccgatatttc tgaaccagtt aatgtatatc ttttagccgc cgtatattcc 38760
gatttcaatg acgaagtaac gtcattaaac gattacacac aggatgaatt gattaatgtt 38820
ttaccatttg acatcaaaaa gctgttatat ctaaaattta agactaaaga aacgaataga 38880
atatactcta ttcttcaaga gatgtctgaa acgtattctc ttccaccaca tccatcaatt 38940
gtaaaagttt tattgggaga attggtcaga caattttttt ataataattc tcgtattaag 39000
tataacgact ccaagttact taaaatggtt acatcagtta taaaaaataa agaagacgct 39060
aggaattaca tagatgatat tgtaaacggt cacttctttg tatcgaataa agtatttgat 39120
aaatctcttt tatacaaata cgaaaacgat attattacag taccgtttag actttcctac 39180
gaaccatttg tttggggagt taactttcgt aaagaatata acgtggtatc ttctccataa 39240
aactgatgaa atatataaag aaataaatgt cgagctttgt taccaatgga taccttccag 39300
ttacattgga accacacgag ctgacgttag acataaaaac taatattagg aatgccgtat 39360
ataagacgta tctccataga gaaattagtg gtaaaatggc caagaaaata gaaattcgtg 39420
aagacgtgga attacctctc ggcgaaatag ttaataattc tgtagttata aacgttccgt 39480
gtgtaataac ctacgcgtat tatcacgttg gggatatagt cagaggaaca ttaaacatcg 39540
aagatgaatc aaatgtaact attcaatgtg gagatttaat ctgtaaacta agtagagatt 39600
cgggtactgt atcatttagc gattcaaagt actgcttttt tcgaaatggt aatgcgtatg 39660
acaatggcag cgaagtcact gccgttctaa tggaggctca acaaggtatc gaatctagtt 39720
ttgtttttct cgcgaatatc gtcgactcat aaaaaagaga atagcggtaa gtataaacac 39780
gaatactatg gcaataattg cgaatgtttt attctcttcg atatattttt gataatatga 39840
aaaacatgtc tctctcaaat cggacaacca tctcataaaa tagttctcgc gcgctggaga 39900
ggtagttgct gctcgtataa tctccccaga ataatatact tgcgtgtcgt cgttcaattt 39960
atacggattt ctatagttct ctgttatata atgcggtttt ccatcatgat tagacgacga 40020
caatagtgtt ctgaatttag atagttgatc agaatgaatg tttattggcg ttggaaaaat 40080
tatccataca gcgtctgcag agtggttgat agttgttcct agatatgtaa aataatccaa 40140
cttactaggc agcaaattgt ctagataaaa tactgaatca aacggtgcag acgtattggc 40200
ggatctaatg gaatccaatt gattaactat cttttgaaaa tatacatttt tatgatccaa 40260
tacttgtaag aatatagaaa taatgataag tccatcatcg tgtttttttg cctcttcata 40320
agaactatat tttttcttat tccaatgaac aagattaatc tctccagagt atttgtacac 40380
atctatcaag tgattggatc cataatcgtc ttcctttccc caatatatat gtagtgatga 40440
taacacatat tcattgggga gaaaccctcc acttatatat cctcctttaa aattaatcct 40500
tactagtttt ccagtgttct ggatagtggt tggtttcgac tcattataat gtatgtctaa 40560
cggcttcaat cgcgcgttag aaattgcttt tttagtttct atattaatag gagatagttg 40620
ttgcggcata gtaaaaatga aatgataact gtttaaaaat agctcttagt atgggaatta 40680
caatggatga ggaagtgata tttgaaactc ctagagaatt aatatctatt aaacgaataa 40740
aagatattcc aagatcaaaa gacacgcacg tgtttgctgc gtgtataaca agtgacggat 40800
atccgttaat aggagctaga agaacttcat tcgcgttcca ggcgatatta tctcaacaaa 40860
attcagattc tatctttaga gtatccacta aactattacg gtttatgtac tacaatgaac 40920
taagagaaat ctttagacgg ttgagaaaag gttctatcaa caatatcgat cctcactttg 40980
aagagttaat attattgggt ggtaaactag ataaaaagga atctattaaa gattgtttaa 41040
gaagagaatt aaaagaggaa agtgatgaac gtataacagt aaaagaattc ggaaatgtaa 41100
ttctaaaact tacaacgcgc gataaattat ttaataaagt atatataggt tattgcatgg 41160
cgtgttttat taatcaatcg ttggaggatt tatcgcatac tagtatttac aatgtagaaa 41220
ttagaaagat taaatcatta aatgattgta ttaacgacga taaatacgaa tatctgtctt 41280
atatttataa tatgctagtt aatagtaaat gaacttttac agatctagta taattagtca 41340
gattattaag tataatagac gactagctaa gtctattatt tgcgaggatg actctcaaat 41400
tattacactc acggcattcg ttaaccaatg cctatggtgt cataaacgag tatccgtgtc 41460
cgctatttta ttaactactg ataacaaaat attagtatgt aacagacgag atagttttct 41520
ctattctgaa ataattagaa ctagaaacat gtttagaaag aaacgattat ttctgaatta 41580
ttccaattat ttgaacaaac aggaaagaag tatactatcg tcattttttt ctctagatcc 41640
agctactgct gataatgata gaatagacgc tatttatccg ggtggcatac ccaaaagggg 41700
tgagaatgtt ccagagtgtt tatccaggga aattaaagaa gaagttaata tagacaattc 41760
ttttgtattc atagacactc ggttttttat tcatggcatc atagaagata ccattattaa 41820
taaatttttt gaggtaatct tctttgtcgg aagaatatct ctaacgagtg atcaaatcat 41880
tgatacattt aaaagtaatc atgaaatcaa ggatctaata tttttagatc cgaattcagg 41940
taatggactc caatacgaaa ttgcaaaata tgctctagat actgcaaaac tcaaatgtta 42000
tggccataga ggatgttatt acgaatcatt aaaaaaatta actgaggatg attgattaga 42060
aaatataaat taatttacca tcgtgtattt ttataacggg attgtccggc atatcatgta 42120
gatagttacc gtctacatcg tatactcgac catctacgcc tttaaatcct ctatttattg 42180
acattaatct attagaattg gaataccaaa tattagtacc ctcaattagt ttattggtaa 42240
tatttttgtt agacgataga tcgatggctc ttgaaaccaa ggttttccaa ccggactcat 42300
tgtcgatcgg tgagaagtct ttttcattag catgaatcca ttctaatgat gtatgtttaa 42360
acactctaaa caattggaca aattcttttg atttgctttg aatgatttca aataggtctt 42420
cgtctacagt aggcatacca ttagataatc tagccattat aaagtgcacg tttacatatc 42480
tacgttctgg aggagtaaga acgtgactat tgagacgaat ggctcttcct actatctgac 42540
gaagagacgc ctcgttccat gtcatatcta aaatgaagat atcattgatt gagaagaagc 42600
taataccctc gcctccacta gaagagaata cgcatgtttt aatgcattct ccgttagtgt 42660
ttgattcttg gttaaactca gccaccgcct tgattctagt atcttttgtt ctagatgaga 42720
actctatatt agagatacca aagactttga aatatagtaa taagatttct attcctgact 42780
gattaacaaa tggttcaaag actagacatt taccatggga tgctaatatt cccaaacata 42840
catctataaa tttgacgctt ttctctttta attcagtaaa tagagagata tcagccgcac 42900
tagcatcccc tcccaatagt tctccccttt taaaggtatc taatgcagat ttagaaaatt 42960
ctctatctct taatgaattt ttaaaatcat tatatagtgt tgctatctct tgcgcgtatt 43020
cgcccggatc acgattttgt ctttcaggaa agctatcgaa cgtaaacgta gtagccatac 43080
gtctcagaat tctaaatgat gatatacctg tttttatttc agcgagttta gccttttgat 43140
aaatttcttc ttgctttttc gacatattaa cgtatcgcat taatactgtt ttcttagcga 43200
atgatgcaga cccttctacg tcatcaaaaa tagaaaactc gttattaact atgtacgaac 43260
ataggcctcc tagtttggag actaattctt tttcatcaac tagacgttta ttctcaaata 43320
gcgattggtg ttgtaaggat cctggtcgta gtaagttaac caacatggtg aattcttgca 43380
cactattgac gataggtgta gccgataaac aaatcatctt atggtttttt aatgcgatgg 43440
tcttagataa aaaattatat actgaacgag taggacggat cttaccatct tctttgatta 43500
atgatttaga aatgaagtta tgacattcat caataatgac gcatattcta ctcttggaat 43560
taatagtttt gatattagta aaaaatttat ttctaaaatt ttgatcatcg taattaataa 43620
aaatacaatc cttcgttatc tctggagcgt atctgagtat agtgttcatc caaggatctt 43680
ctatcaaagc ctttttcacc aataagataa tagcccaatt cgtataaata tccttaagat 43740
gtttgagaat atatacagta gtcattgttt taccgacacc cgtttcatgg aacaataaaa 43800
gagaatgcat actgtctaat cctaagaaaa ctcttgctac aaaatgttga taatccttga 43860
ggcgtactac gtccgacccc atcatttcaa caggcatatt agtagttctg cgcaatgcat 43920
aatcgatata ggccgcgtgt gatttactca tttatgagtg ataagtaata actatgtttt 43980
aaaaatcaca gcagtagttt aactagtctt ctctgatgtt tgttttcgat actttttgaa 44040
tcagaagtca tactagaata aagcaacgag tgaacgtaat agagagcttc gtatactcta 44100
ttcgaaaact ctaagaactt attaatgaat tccgtatcca ctggattgtt taaaatacta 44160
aattgaacac tgttcacatc cttccaagaa gaagacttag tgacggactt aacatgagac 44220
ataaataaat ccaaattttt tttacaaaca tcactagcca ccataatggc gctatctttt 44280
aaccagctat cgcttacgca ttttagcagt ctaacatttt taaagagact acaatatatt 44340
ctcatagtat cgattacacc tctaccgaat aaagttggaa gtttaataat acaatatttt 44400
tcgtttacaa aatcaaataa tggtcgaaac acgtcgaagg ttaacatctt ataatcgcta 44460
atgtatagat tgttttcagt gagatgatta ttagatttaa tagcatctcg ttcacgtttg 44520
aacagtttat tgcgtgcgct gaggtcggca actacggcgt ccgctttagt actcctccca 44580
taatacttta cgctattaat ctttaaaatt tcatagactt tatctagatc gctttctggt 44640
aacatgatat catgtgtaaa aagttttaac atgtcggtcg gcattctatt tagatcatta 44700
actctagaaa tctgaagaaa gtaattagct ccgtattcca gactaggtaa tgggctttta 44760
cctagagaca gattaagttc tggcaatgtt tcataaaatg gaagaaggac atgcgttccc 44820
tcccggatat tttttacaat ttcatccatt tacaactcta tagtttgttt tcattattat 44880
tagttattat ctcccataat cttggtaata cttacccctt gatcgtaaga taccttatac 44940
aggtcattac atacaactac caattgtttt tgtacataat agattggatg gttgacatcc 45000
atggtggaat aaactactcg aacagatagt ttatctttcc ccctagatac attagccgta 45060
atagttgtcg gcctaaagaa tatctttggt gtaaagttaa aagttagggt tcttgttcca 45120
ttattgcttt ttgtcagtag ttcattataa attctcgaga tgggtccgtt ctctgaatat 45180
agaacatcat ttccaaatct aacttctagt ctagaaataa tatcggtctt attcttaaaa 45240
tctattccct tgatgaaggg atcgttaatg aacaaatcct tggcctttga ttcggctgat 45300
ctattatctc cgttatagac gttacgttga ctagtccaaa gacttacagg aatagatgta 45360
tcgatgatgt tgatactatg tgatatgtga gcaaagattg ttctcttagt ggcatcacta 45420
tatgttccag taatggcgga aaacttttta gaaatgttat atataaaaga attttttcgt 45480
gttccaaaca ttagcagatt agtatgaaga taaacactca tattatcagg aacattatca 45540
atttttacat acacatcagc atcttgaata gaaacgatac catcttctgg aacctctacg 45600
atctcggcag actccggata accagtcggt ggaccatcgc taacaataac tagatcatcc 45660
aacaatctac tcacatatgc atctatataa tctttttcat cttgtgagta ccctggatac 45720
gaaataaatt tattatccgt atttccataa taaggtttag tataaacaga gagcgatgtt 45780
gccgcatgaa cttcagttac agtcgccgtt ggttggttta tttgacctat tactctccta 45840
ggtttctcta taaatgatgg tttaatttgt acattcttaa ccatatatcc aataaagctc 45900
aattcaggaa cataaacaaa ttctttgttg aacgtttcaa agtcgaacga agagtcacga 45960
ataacgatat cggatactgg attgaaggtt accgttacgg taatttttga atcggatagt 46020
ttaagactgc tgaatgtatc ttccacatca aacggagttt taatataaac gtatactgta 46080
gatggttctt taatagtgtc attaggagtt aggccaatag aaatatcatt aagttcacta 46140
gaatatccag agtgtttcaa agcaattgta ttattgatac aattattata taattcttcg 46200
ccctcaattt cccaaataac accgttacac gaagagatag atacgtgatt aatacattta 46260
tatccaacat atggtacgta accgaatctt cccatacctt taacttctgg aagttccaaa 46320
ctcagaacca aatgattaag cgcagtaata tactgatccc taatttcgaa gctagcgata 46380
gcctgattgt ctggaccatc gtttgtcata actccggata gagaaatata ttgcggcata 46440
tataaagttg gaatttgact atcgactgcg aagacattag accgtttaat agagtcatcc 46500
ccaccgatca aagaattaat gatagtatta ttcattttct atttaaaatg gaaaaagctt 46560
acaataaact ccgtagagaa atatctataa tttgtgagtt ttccttaaag taacagcttc 46620
cgtaaacgcc gtctttatct cttagtaagt ttattgtatt tataaccttt tccttatctt 46680
catagaatac taaaggcaac aaagaaattt ttggttcttc tctaagagct acgtgagact 46740
taaccataga cgccaacgaa tccctacata ttttagaaca gaaataccca acttcaccac 46800
ccttgaatgt ctcaatacta ataggtttaa aaaccaaatc ttgattacaa aaccaacact 46860
tatcaattac actatttgtc ttaatagaca catctgccat agatttataa tactttggta 46920
gtatacaagc gagtgcttct tctttagcgg gcttaaagac tgctttaggt gctgaaataa 46980
ccacatctgg aaggcttact cgcttagcca tttaattacg gaactatttt tttatacttc 47040
taatgagcaa gtagaaaacc tctcatctac aaaaacatac tcgtgtccat aatcctctac 47100
catagttaca cgttttttag atctcatatg tgctaaaaag ttttcccata ctaattggtt 47160
actattattt ttcgtataat ttttaacagt ttgaggtttt agatttttag ttacagaagt 47220
gatatcgaat attttatcca aaaagaatga ataattaatt gtcttagaag gagtgttttc 47280
ttggcaaaag aataccaagt gcttaaatat ttctactact tcattaatct tttctgtact 47340
cagattcagt ttctcatctt ttacttgatt gattatttca aagactaact tataatcctt 47400
tttatttatt ctctcgttag ccttaagaaa actagataca aaatttgcat ctacatcatc 47460
cgtggatatt tgattttttt ccatgatatc caagagttcc gagataattt ctccagaaca 47520
ttgatgagac aataatctcc gcaatacatt tctcaaatga ataagtttat tagacacatg 47580
gaagtttgac tttttttgta cctttgtaca tttttgaaat accgactcgc aaaaaataca 47640
atattcatat ccttgttcag atactatacc gttgtgtcta caaccgctac ataatcgtag 47700
attcatgtta acactctacg tatctcgtcg tccaatattt tatataaaaa cattttattt 47760
ctagacgttg ccagaaaatc ctgtaatatt tttagttttt tgggctgtga ataaagtatc 47820
gccctaatat tgttaccgtc ttccgccaat atagtagtta aattatccgc acatgcaaaa 47880
gaacaccgct taggcggatt cagtacaatg ttatattttt cgtaccaact catttaaata 47940
tcataatcta aaatagttct gtaatatgtc tagcgctaat atattgatca taatcctgtg 48000
cataaattaa gatacaacaa tgtctcgaaa tcatcgacat ggcttcttcc atagttagaa 48060
gatcgtcgtc aaagttagca acgtgattca tcaacatttg ctgttttgag gcagcaaata 48120
ctgaaccgtc gccattcaac cattcataaa aaccatcgtc tgaatccatt gataatttct 48180
tgtactggtt tttgagagct cgcatcaatc tagcatttct agctcccgga ttgaaaacag 48240
aaagaggatc gtacatccag ggtccatttt ctgtaaatag aatcgtataa tgtcccttca 48300
agaagatatc agacgatcca caatcaaaga attggtctcc gagtttgtaa caaactgcgg 48360
actttaacct atacatgata ccgtttagca tgatttctgg tgatacgtca atcggagtat 48420
catctattag agatctaaag ccggtgtaac attctccacc aaacatattc ttattctgac 48480
gtcgttctac ataaaacatc attgctccat taacgataac aggggaatga acagcactac 48540
ccatcacatt agttcccaat ggatcaatgt gtgtaactcc agaacatctt ccatatccta 48600
tgttaggagg agcgaacacc actcttccac tattgccatc gaatgccata gaataaatat 48660
ccttggaatt gatagaaatc ggactgtcgg atgttgtgat catcttcata ggattaacaa 48720
ctatgtatgg tgccgcctga agtttcatat cgtaactgat gccgtttata ggtctagcca 48780
cagaaaccaa cgtaggtcta aatccaacta tagacaaaat agaagccaat atctgttcct 48840
catctgtcat aacttgagag catccagtat gaataatctt cattagatgg ggatctaccg 48900
catcatcatc gttacaataa aaaattccca ttctaatgtt cataattgct tttctaatca 48960
tggtatgcat gtttgctctc tgaatctctg tggaaattag atctgataca cctgtaatca 49020
ctatcggatt atcctccgta agacgattaa ccaacaacat ataattataa gactttactt 49080
ttctaaattc ataaagttgc tggattaggc tataggtgtc tccatgtaca tacgcgttct 49140
cgagcgcagg aagtttaata ccgaatagtg ccatcagaat aggatgaata tagtaattag 49200
tttctggttt tctataaata aaagacaaat cttgtgaact agacatatcg gtaaaatgca 49260
tggattggaa tcgtgtagtc gacagaagaa tatgatgatt agatggagag tatattttat 49320
ctaactcttt gagttggtca ccgattctag gactagctcg agaatgaata agtactaaag 49380
gatgagtaca tttcacagaa acactagcat tgttcaatgt gctctttaca tgggtaagga 49440
gttgaaatag ctcgtttcta tttgttctga caatatttag tttattcata atgttaagca 49500
tatcctgaat agtaaagtta gatgtgtcat acttgttagt agttagatat ttagcaattg 49560
cattcccatc atttctcaat ctcgtactcc aatcatgtgt agatgctact tcgtcgatgg 49620
aaaccataca atcctttttg ataggctgtt gagattgatt atttcctgca cgtttaggtt 49680
tggtacgttg atttctagcc cctgcggata taaagtcatc gtctacaatt tgggacaatg 49740
aattgcatac actacaagac aaagatttat cagaagtgtg aatatgatct tcatctacca 49800
aagaaagagt ttgattagta taactagatt ttagtcctgc gttagatgtt aaaaaaacat 49860
cgctattgac cacggcttcc attatttata ttcgtagttt ttactcgaaa gcgtgatttt 49920
aatatccaat cttattactt ttggaatcgt tcaaaacctt tgactagttg tagaatttga 49980
tctattgccc tacgcgtata ctcccttgca tcatatacgt tcgtcaccag atcgtttgtt 50040
tcggcctgaa gttggtgcat atctctttca acattcgaca tgagatcctt aagggccata 50100
tcgtctagat tttgttgaga tgctgctcct ggatttggat tttgttgtgc tgttgtacat 50160
actgtaccac cagtaggtgt aggagtacat acagtggcca caataggagg ttgaggaggt 50220
gtaaccgttg gagtagtaca agaaatattt ccatccgatt gttgtgtaca tgtagttgtt 50280
ggtaacgtct gagaaggttg ggtagatggc ggtgtcgtcg tcttttgatc tttattaaat 50340
ttagagataa tatcctgaac agcattgctc ggcgtcaacg ctggaaggag tgaactcgcc 50400
ggcgcatcag tatcttcaga cagccaatca aaaagattag acatatcaga tgatgtatta 50460
gtttgttgtc gtggttttgg tgtaggaaca gtactactag gtagaagaat aggagccggt 50520
gtagctgttg gaaccggctg tggagttata tgaatagttg gttgtagcgg ttggataggc 50580
tgtctgctgg cgaccgtcat attatctcta gctagttgtt ctcgcaactg tctttgataa 50640
tacgactctt gagactttag tcctatttca atcgcttcat cctttttcgt atccggatcc 50700
ttttcttcag aataatagat tgacgacttt ggtgtagagg attctgccag cccctgtgag 50760
aacttgttaa agaagtccat ttaaggcttt aaaattgaat tgcgattata agattaaatg 50820
gcagacacag acgatattat cgactatgaa tccgatgatc tcaccgaata cgaggatgat 50880
gaagaagagg aagaagatgg agagtcacta gaaactagtg atatagatcc caaatcttct 50940
tataagattg tagaatcagc atccactcat atagaagatg cgcattccaa tcttaaacat 51000
atagggaatc atatatctgc tcttaaacga cgctatacta gacgtataag tctatttgaa 51060
atagcgggta taatagcaga aagctataac ttgcttcaac gaggaagatt acctctagtt 51120
tcagaatttt ctgacgaaac gatgaagcaa aatatgctac atgtaattat acaagagata 51180
gaggagggtt cttgtcctat agtcatcgaa aagaacggag aattgttgtc ggtaaacgat 51240
tttgacaaag atggtctaaa attccatcta gactatatta tcaaaatttg gaaacttcaa 51300
aaacgatatt agaatttata cgaatatcgt tctctaaatg tcacaatcaa gtctcgcatg 51360
ttcagcaatt tattgtcgta ctttatatcg tgttcattaa cgatatcttg caaaatagta 51420
atgattctat cttccttcga tagatattct tcagagatta ttgtcttata ttttttcttg 51480
ttatccgata tgaatttgat aagactttga acattattga tacccgtctg tttaattttt 51540
tctacagata ttttagtttt ggcagattct atcgtatctg tcaatagaca tccaacatcg 51600
acattcgacg tcaattgtct ataaatcaac gtataaattt tagaaataac attagcgaat 51660
tgttgtgcat tgatgtcgtt attctgaaac agtatgattt taggtagcat tttcttaaca 51720
aagagaacgt atttattgtt actcagttga acagatgata tatccagatt actaacgcat 51780
ctgattccgt ataccaaact ttcagaagaa atggtgtaca attgtttgta ttcattcaat 51840
gtctcttttt cagaaattag tttagagtcg aatactgcaa taattttcaa gagatagttt 51900
tcatcagata agattttatt tagtgtagat atgataaaac tattgttttg ttggagaact 51960
tgatacgccg cgttctctgt agtcgacgct ctcaaatggg aaacaatctc cattattttt 52020
ttggaatcgg atactatatc ttcggtatct tgacgcagtc tagtatacat agagttaaga 52080
gagattagag tttgtacatt aagcaacatg tctctaaatg tggctacaaa cttttccttt 52140
ttcacataat ctagtttatt atataccgat ttcacaacgg caccagattt aaggaaccag 52200
aatgaaaaac tctgataact acaatatttc atcatagtta cgattttatc atcttctata 52260
gttggtgtaa tagcgcatac ctttttctcc aagactggaa ccaacgtcat aaaaatgttt 52320
aaatcaaaat ccatatcaac atctgatgcg ctaagaccag tctcgcgttc aagattatct 52380
ttactaatgg tgacgaactc atcatataga actctaagtt tgtccattat ttatttacag 52440
atttagttgt ttaatttatt tgtgctcttc cagagttggg atagtatttt tctaacgtcg 52500
gtattatatt attaggatct acgttcatat gtatcataat attaatcatc cacgttttga 52560
taaatctatc tttagcttct gaaataacgt atttaaacaa aggagaaaaa tatttagcta 52620
cggcatcaga cgcaataaca ttttttgtaa atgtaacgta tttagacgac agatcttcgt 52680
taaaaagttt tccatctatg tagaatccat cggttgttaa caccattccc gcgtcagatt 52740
gaataggagt ttgaatagtt tgttttggaa atagatcctt caataactta tagttgggtg 52800
ggaaaaaatc gattttatca ctagactctt tcttttttac tatcattacc tcatgaacta 52860
tttcttgaat gagtatatgt attttctttc ctatatcgga cgcgttcatt ggaaaatata 52920
ccatgtcgtt aactataaga atatttttat cctcgtttac aaactgaata atatcagatg 52980
tagttcgtaa acgaactata tcatcaccag cacaacatct aactatatga tatccactag 53040
tttcctttag ccgtttatta tcttgttcca tattagcagt cattccatca tttaagaagg 53100
cgtcaaagat aatagggaga aatgacattt tggattctgt tacgacttta ccaaaattaa 53160
ggatatacgg acttactatc tttttctcaa cgtcgatttg atgaacacac gatgaaaatg 53220
tgcttctatg agattgatca tgtagaaaac aacaagggat acaatatttc cgcatatcat 53280
gaaatatatt aagaaatccc accttattat atttccccaa aggatccatg catgtaaaca 53340
ttatgccgtt atcattaata aagacttctt tctcatcgga tttgtaaaag ttgttactga 53400
tttttttcat tccaggatct agataattaa taatgatggg ttttctattc ttattctttg 53460
tattttggca tatcctagac cagtaaacag tttccacttt ggtaaaatca gcagactttt 53520
gaacgctatt aaacatggca ttaatggcaa taactaaaaa tgtaaaatat ttttctatgt 53580
taggaatatg gtttttcact ttaatagata tatggttttt ggccaaaatg atagatattt 53640
ttttatccga ggatagtaaa atattattag tcgccgtctc tataaaaatg aagctagtct 53700
cgatatccaa ttttattcta gaattgatag gagtcgccaa atgtacctta tacgttatat 53760
ctcccttgat gcgttccatt tgtgtatcta tatcggacac aagatctgta aatagtttta 53820
cgttattaat catcacggta tcgccgtcgc tagataacgc taatgtacca tccaagtccc 53880
aaatggagag atttaactgt tcatcgttta gaataaaatg attaccggtc atattaataa 53940
agtgttcatc gtatctagat aacaacgact tataattaat gtccaagtct tgaactcgct 54000
gaatgatctt ttttaaccca gttagtttta gattggtacg aaatatattg ttaaactttg 54060
attctacagt aatgtccaaa tctagttgtg gaaatacttc catcaacatt gtttcaaact 54120
tgataatatt attatctaca tcttcatacg atccaaattc cggaatagat gtatcacatg 54180
ctcttgccac ccagataacc aaaaagtcac acgctccagg atatacattg tataaaaagc 54240
tatcgttttt tagtagtgtt tttttctgag tatatacgaa gggattaaaa atagtattat 54300
caacgtaact atattccaaa ttattcttat gagaatagat aataatatcg tccttaatat 54360
ctaacaaatt tcctaaatat ccctttaatt gagtcattcg aagcgtcaat agaatatgtc 54420
tcttaactat ttccggctgt tgtatattta aatgacttcg taaaaaataa tatatgggcg 54480
acttctcatc tatgtaatca tatggagtga gatatagggc tcgttctacc tcctgcccct 54540
tacccacctg taataccaat tgcggactta ctatatatcg catatttata tcgtggggta 54600
aagtgaaaat ctactaccga tgatgtaagt cttacaatgt tcgaaccagt accagatctt 54660
aatttggagg cctccgtaga actaggggag gtaaatatag atcaaacaac acctatgata 54720
aaggaaaata gcggttttat atcccgtagt agacgtctat tcgcccatag atctaaggat 54780
gatgagagaa aactagcact acgattcttt ttacaaagac tttatttttt agatcataga 54840
gagattcatt atttgttcag atgcgttgac gctgtaaaag acgtcactat taccaaaaaa 54900
aataacatta tcgtggcgcc ttatatagca cttttaacta tcgcatcaaa aggatgcaaa 54960
cttacagaaa caatgattga agcatttttt ccagaactat ataatgaaca tagtaagaaa 55020
tttaaattca actctcaagt atccatcatc caagaaaaac tcggatacca gtttggaaac 55080
tatcacgttt atgattttga accgtattac tctacagtag ctctggctat tcgagatgaa 55140
cattcatctg gcatttttaa tatccgtcaa gagagttatc tggtaagttc attatctgaa 55200
ataacatata gattttatct aattaatcta aaatctgatc ttgttcaatg gagtgctagt 55260
acgggcgctg taattaatca aatggtaaat actgtattga ttacagtgta tgaaaagtta 55320
caactggtca tagaaaatga ttcacaattt acatgttcat tggctgtgga atcaaaactt 55380
ccaataaaat tacttaaaga tagaaatgaa ttatttacaa aattcattaa cgagttaaaa 55440
aagaccagtt cattcaagat aagcaaacgc gataaggata cgctactaaa atattttact 55500
taggactgga gttagaattt atagacgact catttcgttt atcattgtta ctattattac 55560
tattactatc attattagtg ttggcattat tagtattctt cttgtcatct tgttcagaaa 55620
tatacagcaa tgctatacct aatactaaat acattatcat gctcgcaatg gctctaacaa 55680
caacgaacca aaatgaattt ggtcgtagct tttgttcaca aaaatacata aagaaatgtc 55740
tacataaatc tatggcgcca ttggctactt gaaatagcgc cagtcctcct acagatttta 55800
atatagctgt ataacatgac atttattcat catcaaaaga gacagagtca ccatctgtca 55860
tatttagatt ttttttcatg tgttcaaagt atcctctact catttcatta taatagttta 55920
tcatacttag aattttagga cggatcaatg agtaagactt gactagatcg tcagtagtaa 55980
tttgtgcatc gtctattctg catccgcttc gtcgaataat gtatagcatc gctttgagat 56040
tctccatagc tatcaagtct ttatacaatg acatggaaat atctgtgaat actttatact 56100
tctccaacat cgatgcctta acatcatcgc ctactttagc attgaaaata cgttctattg 56160
tgtagatgga tgtagcaaga tttttaaaca acaatgccat cttacacgat gattgcctca 56220
agtctccaat cttttgttta gaacgattag ctacagagtt caacgcttgg ctgactagca 56280
tattattatc tttagaaatt gtattcttca atgaggcgtt tatcatatct gtgatttcgt 56340
tagtcatatt acagtctgac tgggttgtaa tgttatccaa catatcacct atggatacgg 56400
tacacgtacc agcatttgta ataatcctat ctaagatgtt gtatggcatt gcgcagaaaa 56460
tatcttctcc tgtaatatct ccactctcga taaatctact cagattattc ttaaatgcct 56520
tattctctgg agaaaagata tcagtgtcca tcatttcatt aatagtatac gcagaaaaga 56580
taccacgagt atcaattcta tccaagatac ttatcggttc cgagtcacag ataatggttt 56640
cctctccttc gggagatcct gcatagaaat atctaggaca atagtttcta tactgtctgt 56700
aactctgata atctctaaag tcactaactg ataccatgaa attgagaaga tcaaacgctg 56760
aagtaatcaa tttttctgcc tcgtttttac tacaactagt tttcatcaat gtagcgacga 56820
tgtattgttt agttactctt ggtctaatac tgatgataga gatattattg cttcccataa 56880
tggatcttct agtagtcacc ttaaagccca ttgatgcgaa tagcagatag ataaagtctt 56940
ggtatgactc ctttctaata tagtacggac tacctttgtc acccaacttt atacccacat 57000
aagccataac aacctcttta atagccgttt catgaggttt atcagccatg agcctgagta 57060
gttggaagaa tctcatgaat cccgtctcag aaagtcctat atgcatgata gatttatctt 57120
tcctgggaaa ctctcgtata gtcatagatg aaatactctt caaagtttct gaaataagat 57180
tagtaacagt cttacctccg actactctgg gtaacaaaca tactctaata ggtgttttct 57240
ctgcggagat aatatcagaa aggatagagc aataagtagt attattgtga ttataaagac 57300
cgaatacata acaggtagaa tttataaaca tcatgtcctg aaggttttta gacttgtatt 57360
cctcgtaatc cataccgtcc caaaacatgg atttggtaac tttgatagcc gtagatcttt 57420
gttccttcgc caacaggtta aagaaattaa taaagaattt gttgtttcta tttatgtcca 57480
caaattgcac gtttggaagc gccacggtta cattcactgc agcattttga ggatcgcgag 57540
tatgaagtac gatgttattg tttactggta tatctggaaa gaaatctacc agtctaggaa 57600
taagagattg atatcgcata gaaatagtaa agtttataat ctcatcatcg aagagcattt 57660
tgttaccatt gtaataaata tccactctgt catatgtata aatgaagtac tgttcaaaca 57720
tgatgagatg tttatatgtt ggcatagtag tgagatcgac gtttggtaat ggcaatgtat 57780
taagattaac tccataatgt ctagcagcat ctgcgatgtt ataagcgtcg tcaaagcggg 57840
gtcgatcttg tattgttata tattgtctaa cacctataag attatcaaaa tcttgtctgc 57900
ttaatacacc gttaacaatt tttgccttga attcttttat tggtgcatta ataacatcct 57960
tatagaggat gttaaacaaa taagtgttat caaagttaag atctggatat ttcttttctg 58020
ctagaacatc cattgagtcg gagccatctg gtttaatata accaccgata aatctagctc 58080
tgtattctgt atccgtcaat ctaatattaa gaaggtgttg agtgaaaggt ggaagatcgt 58140
aaaagctgtg agtattaatg ataggattag tttccgaact aatgttaatt ggggtattaa 58200
taatatctat atttccagcg ttaagtgtaa cattaaacag ttttaattca cgtgacgtgg 58260
tatcaattaa ataattaatg cccaatttgg atatagcagc ctgaagctca tcttgtttag 58320
ttacggatcc taatgagtta ttaagcaata tatcgaacgg atgaacgaag gttgttttaa 58380
gttggtcaca tactttgtaa tctagacata gatgcggaag aacggtagaa actatacgaa 58440
ataaatattc agagtcctct aattgatcaa gagtaactat tgacttaata ggcatcattt 58500
atttagtatt aaatgacgac cgtaccagtg acggatatac aaaacgattt aattacagag 58560
ttttcagaag ataattatcc atctaacaaa aattatgaaa taactcttcg tcaaatgtct 58620
attctaactc acgttaacaa cgtggtagat agagaacata atgccgccgt agtgtcatct 58680
ccagaggaaa tatcctcaca acttaatgaa gatctatttc cagatgatga ttcaccggcc 58740
actattatcg aacgagtaca acctcatact actattattg acgatactcc acctcctact 58800
tttcgtagag agttattgat atcggaacaa cgtcaacaac gagaaaaaag atttaatatt 58860
acagtatcga aaaatgctga agcaataatg gaatctagat ctatgataac ttctatgcca 58920
acacaaacac catccttggg agtagtttat gataaagata aaagaattca gatgttggag 58980
gatgaagtgg ttaatcttag aaatcaacga tctaatacaa aatcatctga taatttagat 59040
aattttacca aaatactatt tggtaagact ccgtataaat caacagaagt taataagcgt 59100
atagccatcg ttaattatgc aaatttgaac gggtctccct tatcagtcga ggacttggat 59160
gtttgttcag aggatgaaat agatagaatc tataaaacga ttaaacaata tcacgaaagt 59220
agaaaacaaa aaattatcgt cactaacgtg attattattg tcataaacat tatcgagcaa 59280
gcattgctaa aactcggatt tgaagaaatc aaaggactga gtaccgatat cacttcagaa 59340
attatcgatg tggagatcgg agatgactgc gatgctgtag catcaaaact aggaatcggt 59400
aacagtccgg ttcttaatat tgtattgttt atactcaaga tattcgttaa acgaattaaa 59460
attatttaat ttaatacatt cccatatcca gacaacaatc gtctggatta atctgttcct 59520
gtcgtctcat accggacgac atattaatct ttttattagt aggcatcttt ttagatggtt 59580
tctttttccc agcattaact gagtcgatac ctagaagatc gtgattgatc tctccgacca 59640
ttccacgaac ttctaattgg ccgtctctaa cggtaccata aactatttta ccagcattag 59700
taacagcttg gacaatctga ccatccatcg cattgtacga tgtagtagta actgttgttc 59760
tacgtctagg agcaccagaa gtatttttgg agcccttgga ggctgatgta gaagaagacg 59820
aggattttga ttttggttta catgtaatac attttgaact ctttgatttt gtatcacatg 59880
cgccggcagt cacatctgtt tgagaattaa gattattgtt gcctcctttg acggctgcat 59940
ctccaccgat ttgcgctagt agatttttaa gctgtggtgt aatcttatta actgtttcga 60000
tataatcatc gtaactgctt ctaacggcta aatttttttt atccgccatt tagaagctaa 60060
aaatattttt atttatacag aagatttaac tagattatac aatgaactaa tatgatcctt 60120
ttccagatta tttacaaact tggtattttt tggttctgga ggaggcgaat ttaaattcgg 60180
acttggattc ggattttgtg agttcttgat cttattatac atcgagtata ggatggcgac 60240
ggtaactgct acacaaatac cgatcaacaa aagaatacca atcatttatt gacaataact 60300
tcactattga tcaagtatgc aatatatcat cttttcacta aataagtagt aataatgatt 60360
caacaatgtc gagatatatg gacgataata atttagttca tggaaatatc gctatgattg 60420
gtatgaatga ctccgctaac tctgtggggc gcgcagtgct ttccccacat agaataaatt 60480
agcattccga ctgtgataat aataccaagt ataaacgcca taatactcaa tactttccat 60540
gtacgagtgg gactggtaga cttactaaag tcaataaagg cgaagataca cgaaagaatc 60600
aaaagaatga ttccagcgat tagcacgccg gaaaaataat ttccaatcat aagcatcatg 60660
tccatttaac taataaaaat tttaaatcgc cgaatgaaca aagtggaata taaaccatat 60720
aaaaacaata gtttgtactg caaaaataat atctattttt gttttcgaag atatggtaaa 60780
attaaatagt agtacacagc atgttataac taacagcagc aacggctcgt aattacttat 60840
catttactag acgaaaaggt ggtgggatat tttcttgctc aaataatacg aatatatcac 60900
ccatccattt tatgcgatgt ttatatactc taatctttaa tagatctata gacgacgggt 60960
ttaccaacaa tatagatttt atcgattcat ctaatttaaa cccttcctta aacgtgaatg 61020
atctattatc tggcataacg atgaccctac ctgatgaatc ggacaatgta ctgggccatg 61080
tagaataaat tatcaacgaa ttatcgtcta cgaacattta tatcatttgt tttaatttta 61140
ggacgcgaat aaatagatat aaaatagaaa ataacagata ttacaaccag tgttatggcc 61200
gcgcccaacc aggtaggcag ttttatttta tcttttacta caggttctcc tggatgtacg 61260
tcaccaacgg cggacgtagt tctagtacaa ttagacgtaa gttccgcttg ggaatttttt 61320
aacgctaaag agttaacgtt aatcgtgcac ccaacgtatt tacatctagt tctttgaaca 61380
tcttgattat aatataacca ttttctatct ctagattcgt cggtgcactc atgtaaccaa 61440
cataccctag gtcctaaata tttatctccg gaattagatt ttggataatt cgcgcaccaa 61500
caatttctat ttcctttatg atcgttacaa aagacgtata atgccgtatc cccaaaagta 61560
aaataatcag gacgaataat tctaataaac tcagaacaat atctcgcatc catatgtttg 61620
gagcaaatat cggaataagt agacatagcc ggtttccgtt ttgcacgtaa ccattctaaa 61680
caattggggt ttccaggatc gtttctacaa aatccagtca tgaaatcgtc acaatgttct 61740
gtcttgtaat tattattaaa tatttttgga cagtgtttgg tatttgtctt agaacaacat 61800
tttgccacgc tatcactatc gcccaggaga taatcctttt ttataaaatg acatcgttgc 61860
ccggatgcta tataatcagt agcgtgtttt aaatccttaa tatattcagg agttacctcg 61920
ttctgataat agattaatga tccaggacga aatttgaaag aactacatgg ttctccatga 61980
attaatacat attgtttagc aaattcagga actataaaac tactacaatg atctatcgac 62040
ataccatcta tcaaacaaaa cttgggttta atttctcccg gagatgtttc ataatagtac 62100
gtataacttt cttctgcaaa cttaacagct ctattatatt caggataatt aaaacctaat 62160
tccatatatt tgtctcgtat atctgctatt cctggtgcta ttttgattct attaagagta 62220
acagctgccc ccattcttaa taatcgtcag tatttaaact gttaaatgtt ggtatatcaa 62280
catctacctt atttcccgca gtataaggtt tgttgcaggt atactgttca ggaatggtta 62340
catttatact tcttctatag tcctgtcttt cgatgttcat cacatatgca aagaacagaa 62400
taaacaaaat aatgtaagaa ataatattaa atatctgtga attcgtaaat acattgattg 62460
ccataataat tacagcagct acaatacaca caatagacat tcccacagtg ttgccattac 62520
ctccacgata catttgagtt actaagcaat aggtaataac taagctagta agaggcaata 62580
gaaaagatga gataaatatc atcaatatag agattagagg agggctatat agagccaaga 62640
cgaacaaaat caaaccgagt aacgttctaa catcattatt tttgaagatt cccaaataat 62700
cattcattcc tccataatcg ttttgcatca tacctccatc tttaggcata aacgattgct 62760
gctgttcctc tgtaaataaa tctttatcaa gcactccagc acccgcagag aagtcgtcaa 62820
gcatattgta atatcttaaa taactcattt atatattaaa aaatgtcact attaaagatg 62880
gagtataatc tttatgccga actaaaaaaa atgacttgtg gtcaacccct aagtcttttt 62940
aacgaagacg gggatttcgt agaagttgaa ccgggatcat cctttaagtt tctgatacct 63000
aagggatttt acgcctctcc ttccgtaaag acgagtctag tatttgaaac attaacaacg 63060
accgataata aaatcactag tatcaatcca acaaatgcgc caaagttata tcctcttcaa 63120
cgcaaagtcg tatctgaagt agtttctaat atgaggaaaa tgatcgaatc aaaacgtcct 63180
ctatacatta ctcttcactt ggcgtgtgga tttggtaaga ctattaccac gtgttatctt 63240
atggctacac acggtagaaa aaccgtcatt tgcgtaccca ataaaatgtt aatacatcaa 63300
tggaagacac aggtagaggc agtcggattg gaacataaga tatccataga tggagtaagt 63360
agtctattaa aggaactaaa gactcaaagt ccggatgtat taatagtagt cagtagacat 63420
ctgacaaacg atgccttttg taaatatatc aataagcatt atgatttgtt catcttggat 63480
gaatcacata cgtataatct gatgaacaat acagcagtta caagattttt agcgtattat 63540
cctccgatga tgtgttattt tttaactgct acacctagac cagctaaccg aatttattgt 63600
aacagtatta ttaatattgc caagttatcc gatctaaaaa aaactatcta tgcggtagat 63660
agtttttttg agccatattc cacagacaat attagacata tggtaaaacg actagatgga 63720
ccatctaata aatatcatat atataccgag aagttattat ctgtagacga gcctagaaat 63780
caacttattc ttaataccct ggtagaagaa ttcaagtcag gaactattaa tcgcatttta 63840
gttattacta aactacgtga acatatggta ttattctaca aacgattatt agatcttttc 63900
ggaccagagg ttgtatttat aggagacgcc caaaatagac gtactccaga tatggtcaaa 63960
tcaatcaagg aactaaatag atttatattc gtatccacct tattttattc cggtactggt 64020
ttagatattc ctagtttgga ttcgttgttc atttgctcgg cagtaatcaa caatatgcaa 64080
atagagcaat tactagggag ggtatgtcga gaaacagaac tattagatag gacggtatat 64140
gtatttccta acacatccat caaagaaata aagtacatga taggaaattt catgcaacga 64200
attattagtc tgtctgtaga taaactagga tttaaacaag aaagttatcg gaaacatcaa 64260
gaatccgatc ccacttctgt atgtacaaca tcctccagag aagaacgtgt attaaataga 64320
atatttaact cgcaaaatcg ttaagaagtt taagcgacga tccgcatgct gcgcaggcca 64380
gtgtattacc cctcatagta ttaatataat ccaatgatac ttttgtgatg tcggaaatct 64440
taaccaattt agactgacag gcagaacacg tcatgcaatc atcatcgtca tcgataactg 64500
tagtcttggg cttctttttg cggctcttca ttccggaacg cacattggtg ctatccattt 64560
aggtagtaaa aaataagtca gaatatgccc tataacacga tcgtgcaaaa cctggtatat 64620
cgtctctatc tttatcacaa tatagtgtat cgacatcttt attattattg acctcgttta 64680
tcttggaaca tggaatggga acatttttgt tatcaacggc cacctttgcc ttaattccag 64740
atgttgtaaa attataacta aacagtctat catcgacaca aatgaaattc ttgtttagac 64800
gtttgtagtt tacgtatgcg gctcgttcgc gtctcatttt ttcagatatt gcaggtacta 64860
taatattaaa aataagaatg aaataacata ggattaaaaa taaagttatc atgacttcta 64920
gcgctgattt aactaactta aaagaattac ttagtctgta caaaagtttg aaattttcag 64980
attctgcggc tatagaaaag tataattctt tggtagaatg gggaacatct acttactgga 65040
aaataggcgt gcaaaaggta gctaatgtcg agacgtcaat atctgattat tatgatgagg 65100
taaaaaataa accgtttaat attgatccgg gctattacat tttcttaccg gtatattttg 65160
ggagcgtctt tatttattcg aagggtaaaa atatggtaga acttggatct ggaaactctt 65220
ttcaaatacc agatgatatg cgaagtgcgt gtaacaaagt attagacagc gataacggaa 65280
tagactttct gagatttgtt ttgttaaaca atagatggat aatggaagat gctatatcaa 65340
aatatcagtc tccagttaat atatttaaac tagctagtga gtacggatta aacataccca 65400
aatatttaga aattgaaata gaggaagaca cattatttga cgacgagtta tactctatta 65460
tagaacgctc ttttgatgat aaatttccaa aaatatccat atcgtatatt aagttgggag 65520
aacttaggcg gcaagttgta gactttttca aattctcgtt catgtatatt gagtccatca 65580
aggtagatcg tataggagat aatattttta ttcctagcgt tataacaaaa tcaggaaaaa 65640
agatattagt aaaagatgta gaccatttaa tacgatctaa ggttagagaa catacatttg 65700
taaaagtaaa aaagaaaaac acattttcca ttttatacga ctatgatggg aacggaacag 65760
aaactagagg agaagtaata aaacgaatta tagacactat aggacgagac tattatgtta 65820
acggaaagta tttctctaag gttggtagtg caggcttaaa gcaattgact aataaattag 65880
atattaatga gtgcgcaact gtcgatgagt tagttgatga gattaataaa tccggaactg 65940
taaaacgaaa aataaaaaac caatcagcat ttgatttaag cagagaatgt ttgggatatc 66000
cagaagcaga ttttataacg ttagttaata acatgcggtt caaaatagaa aattgtaagg 66060
ttgtaaattt caatattgaa aatactaatt gtttaaataa cccgagtatt gaaactatat 66120
atggaaactt taaccagttc gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat 66180
tattcgagtg aaataatatg cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt 66240
ttagaagtca aggataactc cgttagggta ttggatatat caaaattaga ctggagttct 66300
gattgggaaa ggcgcatagc taaagatttg tcacaatatg aatacactac agttcttcta 66360
gaacgtcagc ctagaaggtc gccgtatgtt aaatttatct attttattaa aggcttttta 66420
tatcatacat cggctgccaa agttatttgc gtctcgcctg tcatgtctgg taattcatat 66480
agagatcgaa aaaagagatc ggtcgaagca tttcttgatt ggatggacac attcggattg 66540
cgagactccg ttccggatag acgcaaatta gacgatgtag cggatagttt caatttggct 66600
atgagatacg tattagataa atggaatact aattatacac cttataatag gtgtaaatct 66660
agaaattaca taaaaaaaat gtaataacgt tagtaacgcc attatggata atctatttac 66720
ctttctacat gaaatagaag atagatatgc cagaactatt tttaactttc atctaataag 66780
ttgcgatgaa ataggagata tatatggtct tatgaaagaa cgcatttcct cagaggatat 66840
gtttgataat atagtatata ataaagatat acatcctgcc attaagaaac tagtgtattg 66900
cgacatccaa cttactaaac acattattaa tcagaatacg tatccggtat ttaacgattc 66960
ttcacaagtg aaatgttgtc attatttcga cataaactca gataatagca atattagctc 67020
tcgtacagta gagatatttg agagggaaaa gtcatctctt gtatcatata ttaaaactac 67080
caataagaag agaaaggtca attacggcga aataaagaaa actgttcatg gaggcactaa 67140
tgcaaattac ttttccggta aaaagtctga cgagtatctg agtactacag ttagatccaa 67200
cattaatcaa ccttggatca aaaccatttc taagagaatg agagtagata tcattaatca 67260
ctctatagta acgcgtggaa aaagctctat attacaaact atagaaatta tttttactaa 67320
tagaacatgt gtgaaaatat tcaaggattc tactatgcac attattctat ccaaggacaa 67380
ggatgaaaag gggtgtatac acatgattga caaattattc tatgtctatt ataatttatt 67440
tctgttgttc gaagatatca tccaaaacga gtactttaaa gaagtagcta atgttgtaaa 67500
ccacgtactt acggctacgg cattagatga gaaattattc ctaattaaga aaatggctga 67560
acacgatgtt tatggagtta gcaatttcaa aatagggatg tttaacctga catttattaa 67620
gtcgttggat cataccgttt tcccctctct gttagatgag gatagcaaaa taaagttttt 67680
taaggggaaa aagctcaata ttgtagcatt acgatctctg gaggattgta taaattacgt 67740
gactaaatcc gagaatatga tagaaatgat gaaggaaaga tcgactattt taaatagcat 67800
agatatagaa acggaatcgg tagatcgtct aaaagaattg cttctaaaat gaaaaaaaac 67860
actgattcag aaatggatca acgactaggg tataagtttt tggtgcctga tcctaaagcc 67920
ggagtttttt atagaccgtt acatttccaa tatgtatcgt attctaattt tatattgcat 67980
cgattgcatg aaatcttgac cgtcaagcgg ccactcttat cgtttaagaa taatacagaa 68040
cgaattatga tagaaattag caatgttaaa gtgactcctc cagattactc acctataatc 68100
gcgagtatta aaggtaagag ttatgatgca ttagccacgt tcactgtaaa tatctttttt 68160
tctagacact aaataaaata tttaaaatat aatattaatg tactaaaact tatatattat 68220
taatttatct aactaaagtt agtaaattat atatataatt ttataattaa tttaatttta 68280
ctaattttat ttagtgtcta gaaaaaaa 68308
<210> 18
<211> 66390
<212> DNA
<213> Artificial Sequence
<220>
<223> sVAC fragment 2
<400> 18
tttttttcta gacactaaat aaaatattta aaatataata ttaatgtact aaaacttata 60
tattattaat ttatctaact aaagttagta aattatatat ataattttat aattaattta 120
attttactaa ttttatttag tgtctagaaa aaaaattttg ggagcgtctt tatttattcg 180
aagggtaaaa atatggtaga acttggatct ggaaactctt ttcaaatacc agatgatatg 240
cgaagtgcgt gtaacaaagt attagacagc gataacggaa tagactttct gagatttgtt 300
ttgttaaaca atagatggat aatggaagat gctatatcaa aatatcagtc tccagttaat 360
atatttaaac tagctagtga gtacggatta aacataccca aatatttaga aattgaaata 420
gaggaagaca cattatttga cgacgagtta tactctatta tagaacgctc ttttgatgat 480
aaatttccaa aaatatccat atcgtatatt aagttgggag aacttaggcg gcaagttgta 540
gactttttca aattctcgtt catgtatatt gagtccatca aggtagatcg tataggagat 600
aatattttta ttcctagcgt tataacaaaa tcaggaaaaa agatattagt aaaagatgta 660
gaccatttaa tacgatctaa ggttagagaa catacatttg taaaagtaaa aaagaaaaac 720
acattttcca ttttatacga ctatgatggg aacggaacag aaactagagg agaagtaata 780
aaacgaatta tagacactat aggacgagac tattatgtta acggaaagta tttctctaag 840
gttggtagtg caggcttaaa gcaattgact aataaattag atattaatga gtgcgcaact 900
gtcgatgagt tagttgatga gattaataaa tccggaactg taaaacgaaa aataaaaaac 960
caatcagcat ttgatttaag cagagaatgt ttgggatatc cagaagcaga ttttataacg 1020
ttagttaata acatgcggtt caaaatagaa aattgtaagg ttgtaaattt caatattgaa 1080
aatactaatt gtttaaataa cccgagtatt gaaactatat atggaaactt taaccagttc 1140
gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat tattcgagtg aaataatatg 1200
cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt ttagaagtca aggataactc 1260
cgttagggta ttggatatat caaaattaga ctggagttct gattgggaaa ggcgcatagc 1320
taaagatttg tcacaatatg aatacactac agttcttcta gaacgtcagc ctagaaggtc 1380
gccgtatgtt aaatttatct attttattaa aggcttttta tatcatacat cggctgccaa 1440
agttatttgc gtctcgcctg tcatgtctgg taattcatat agagatcgaa aaaagagatc 1500
ggtcgaagca tttcttgatt ggatggacac attcggattg cgagactccg ttccggatag 1560
acgcaaatta gacgatgtag cggatagttt caatttggct atgagatacg tattagataa 1620
atggaatact aattatacac cttataatag gtgtaaatct agaaattaca taaaaaaaat 1680
gtaataacgt tagtaacgcc attatggata atctatttac ctttctacat gaaatagaag 1740
atagatatgc cagaactatt tttaactttc atctaataag ttgcgatgaa ataggagata 1800
tatatggtct tatgaaagaa cgcatttcct cagaggatat gtttgataat atagtatata 1860
ataaagatat acatcctgcc attaagaaac tagtgtattg cgacatccaa cttactaaac 1920
acattattaa tcagaatacg tatccggtat ttaacgattc ttcacaagtg aaatgttgtc 1980
attatttcga cataaactca gataatagca atattagctc tcgtacagta gagatatttg 2040
agagggaaaa gtcatctctt gtatcatata ttaaaactac caataagaag agaaaggtca 2100
attacggcga aataaagaaa actgttcatg gaggcactaa tgcaaattac ttttccggta 2160
aaaagtctga cgagtatctg agtactacag ttagatccaa cattaatcaa ccttggatca 2220
aaaccatttc taagagaatg agagtagata tcattaatca ctctatagta acgcgtggaa 2280
aaagctctat attacaaact atagaaatta tttttactaa tagaacatgt gtgaaaatat 2340
tcaaggattc tactatgcac attattctat ccaaggacaa ggatgaaaag gggtgtatac 2400
acatgattga caaattattc tatgtctatt ataatttatt tctgttgttc gaagatatca 2460
tccaaaacga gtactttaaa gaagtagcta atgttgtaaa ccacgtactt acggctacgg 2520
cattagatga gaaattattc ctaattaaga aaatggctga acacgatgtt tatggagtta 2580
gcaatttcaa aatagggatg tttaacctga catttattaa gtcgttggat cataccgttt 2640
tcccctctct gttagatgag gatagcaaaa taaagttttt taaggggaaa aagctcaata 2700
ttgtagcatt acgatctctg gaggattgta taaattacgt gactaaatcc gagaatatga 2760
tagaaatgat gaaggaaaga tcgactattt taaatagcat agatatagaa acggaatcgg 2820
tagatcgtct aaaagaattg cttctaaaat gaaaaaaaac actgattcag aaatggatca 2880
acgactaggg tataagtttt tggtgcctga tcctaaagcc ggagtttttt atagaccgtt 2940
acatttccaa tatgtatcgt attctaattt tatattgcat cgattgcatg aaatcttgac 3000
cgtcaagcgg ccactcttat cgtttaagaa taatacagaa cgaattatga tagaaattag 3060
caatgttaaa gtgactcctc cagattactc acctataatc gcgagtatta aaggtaagag 3120
ttatgatgca ttagccacgt tcactgtaaa tatctttaaa gaggtaatga ccaaagaggg 3180
tatatccatc actaaaataa gtagttatga gggaaaagat tctcatttga taaaaattcc 3240
gctactaata ggatacggga ataaaaatcc acttgataca gccaagtatc ttgttcctaa 3300
tgtcataggt ggagtcttta tcaataaaca atctgtcgaa aaagtaggaa ttaatctagt 3360
agaaaagatt acaacatggc caaaatttag ggttgttaag ccaaactcat tcactttctc 3420
gttttcctcc gtatcccctc ctaatgtatt accgacaaga tatcgccatt acaagatatc 3480
tctggatata tcacaattgg aagcgttgaa tatatcatcg acaaagacat ttataacggt 3540
caatattgtt ttgctgtctc aatatttatc tagagtgagt ctagaattca ttagacgtag 3600
tttatcatac gatatgcctc cagaagttgt ctatctagta aacgcgataa tagatagtgc 3660
taaacgaatt actgaatcta ttactgactt taatattgat acatacatta atgacctggt 3720
ggaagctgaa cacattaaac aaaaatctca gttaacgatc aacgagttca aatatgaaat 3780
gctgcataac tttttacctc atatgaacta tacacccgat caactaaagg gattttatat 3840
gatatcttta ctaagaaagt ttctctactg tatctaccac acttctagat atccagatag 3900
agattcgatg gtttgtcatc gcatcctaac gtacggcaaa tattttgaga cgttggcaca 3960
tgatgaatta gagaattaca taggcaacat ccgaaacgat atcatgaaca atcacaagaa 4020
cagaggcact tacgcggtaa acattcatgt actaacaact cccggactta atcacgcgtt 4080
ttctagctta ttgagtggaa agttcaaaaa gtcagacggt agttatcgaa cacatcctca 4140
ctattcatgg atgcagaata tttctattcc taggagtgtt ggattttatc cggatcaagt 4200
aaagatttca aagatgtttt ctgtcagaaa ataccatcca agtcaatatc tttacttttg 4260
ttcatcggac gttccggaaa gaggtcctca ggtaggttta gtatctcaat tgtctgtctt 4320
gagttccatt acaaatatac taacgtctga gtatttggat ttggaaaaga aaatttgtga 4380
gtatatcaga tcatattata aagatgatat aagttacttt gaaacaggat ttccaatcac 4440
tatagaaaat gctctagtcg catctcttaa tccaaatatg atatgtgatt ttgtaactga 4500
ctttagacgt agaaaacgga tgggattctt cggtaacttg gaggtaggta ttactttagt 4560
tagggatcac atgaatgaaa ttcgcattaa tattggagcg ggaagattag tcagaccatt 4620
cttggttgtg gataacggag agctcatgat ggatgtgtgt ccggagttag aaagcagatt 4680
agacgacatg acattctctg acattcagaa agagtttccg catgtcatcg aaatggtaga 4740
tatagaacaa tttactttta gtaacgtatg tgaatcggtt caaaaattta gaatgatgtc 4800
aaaggatgaa agaaagcaat acgatttatg tgactttcct gccgaattta gagatggata 4860
tgtggcatct tcattagtgg gaatcaatca caattctgga cccagagcta ttcttggatg 4920
tgctcaagct aaacaagcta tctcttgtct gagttcggat atacgaaata aaatagacaa 4980
tggaattcat ttgatgtatc cagagaggcc aatcgtgatt agtaaggctt tagaaacttc 5040
aaagattgcg gctaattgct tcggccaaca tgttactata gcattaatgt cgtacaaagg 5100
tatcaatcaa gaggatggaa ttatcatcaa aaaacaattt attcagagag gcggtctcga 5160
tatagttacc gcaaagaaac atcaagtaga aattccgttg gaaaacttta ataacaaaga 5220
aagagatagg tctaacgcct attcaaaatt agaaagtaat ggattagtta gactgaatgc 5280
tttcttggaa tccggagacg ctatggcacg aaatatctca tcaagaactc ttgaagatga 5340
ttttgctaga gataatcaga ttagcttcga tgtttccgag aaatataccg atatgtacaa 5400
atctcgcgtt gaacgagtac aagtagaact tactgacaaa gttaaggtac gagtattaac 5460
catgaaagaa agaagaccca ttctaggaga taaatttacc actagaacga gtcaaaaggg 5520
aacagtcgcg tatgtcgcgg atgaaacgga acttccatac gacgaaaatg gtatcacacc 5580
agatgtcatt attaattcta catccatctt ctctagaaaa actatatcta tgttgataga 5640
ggttatttta acagccgcat attctgctaa gccgtacaac aataagggag aaaaccgacc 5700
tgtctgtttt cctagtagta acgaaacatc catcgataca tatatgcaat tcgctaaaca 5760
atgttatgag cattcaaatc cgaaattgtc cgatgaagaa ttatcggata aaatcttttg 5820
tgaaaagatt ctctatgatc ctgaaacgga taagccttat gcatccaaag tattttttgg 5880
accaatttat tacttgcgtc tgaggcattt aactcaggac aaggcaaccg ttagatgtag 5940
aggtaaaaag acgaagctca ttagacaggc gaatgaggga cgaaaacgtg gaggaggtat 6000
caagttcgga gaaatggaga gagactgttt aatagcgcat ggcgcagcca atactattac 6060
agaagtttta aaagactcag aagaggatta tcaagatgtg tatgtttgtg aaaattgtgg 6120
agacatagca gcacaaatca agggtattaa tacatgtctt agatgttcaa aacttaatct 6180
ctctcctctc ttaacaaaaa ttgataccac gcacgtatct aaagtatttc ttactcaaat 6240
gaacgccaga ggcgtaaaag tcaaattaga tttcgaacga aggcctcctt cgttttataa 6300
accattagat aaagttgatc tcaagccgtc ttttctggtg taatattcta gtttggtagt 6360
agatacatat caatatcatc aaattcgaga tccgaattat aaaatgggcg tggattgtta 6420
actatagaat cggacgtctg atattcgaaa atctgtggag ttttaggttt tggtggaggt 6480
gtaactgcta cttgggatac tgaagtctga tattcagaaa gctgggggat gttctggttc 6540
gacatccacc gatggtgtca catcactaat cggttcggta acgtctgtgg atggaggtgc 6600
tacttctaca gaacctgtag cctcagttgt caacggagat acatttttaa tgcgaggaaa 6660
tgtataattt ggtaatggtt tctcatgtgg atctgaagaa gaggtaagat atctactaga 6720
aagataccga tcacgttcta gttctctttt gtagaactta actttttctt tctcagcatc 6780
tagttgatat tccaacctct tcacgttact acgttcagat tccaattcac gttcgcatgg 6840
gttacctccg cagtttttac gagcgatttc acgttcagcc ttcatgcgtc tctccttctc 6900
tctatcgagt ttatcagagc agtctttctg aaggcgatcg aactccataa atttctccaa 6960
cgctttgatt gtttccatag atttccgaag ttcagctttt aggactgtga ttctttttct 7020
ttcgaattca cagctggatg tgcaaccgtt tccattaccg ccatctctaa gtttcttttc 7080
tagatcggca acatttcatc cccatgcctt ttacattcct cgagtctact gtcgtcgaaa 7140
tatcgttcca gctccttttc gacatcaata actttagcac gttgtctctc aagctctctt 7200
ttgtagttat ctgattccct ggcacgttta agatcttcat gcaattgagt cagctcttaa 7260
cacaatctct tgcttcttcg tcatagtact tacaatcact atgggatcca ttgttaccac 7320
gtctacactc ggcgagctcg cgtttaagag attcaatttc ccgtttgtat tggtccatgt 7380
ttccattgct accaccatta gatttacagg ctgctagttg tcgttcgaga tcagaaatac 7440
gggttttctt ggaattgatt tcgtcgatgt acttggcatc gaaacactta ttaagttctt 7500
tttccaattc tacgatttta tttctttcgc gagtcaattc cctcctgtag taactatctg 7560
ttttgtcaga ttcacgctct ctacgtagac tttcttgcaa gttactaatt tgttccctag 7620
cacgtccgag tttagtttta tatgctgaat agagttctga ttcatccttt gagcagatct 7680
ctagcgatcg tttaagattc ctgattctag tctttagcct atttacctcc tcagaagatg 7740
ttccgttacc gttgcgttta cactcgttaa gctgtctatc aagatccatg attctatctc 7800
taagacgttg catctctctt tccatatcag cattgctttc attattacgt ctgcagtcac 7860
tcaactgtct ttcaatatct gagattctat ctctaagacg tcgcatctct ctctgtttcg 7920
gcattggttt cattattacg tctacagtcg ttcaactgtc tttcaagatc tgatattcta 7980
gattggagtc tgctaatctc tgtagcattt tcacggcatt cactcagttg tctttcaaga 8040
tctgagattt tagattggag tctgctaatc tctgtaagat ttcctcctcc gctctcgatg 8100
cagtcggtca acttattctc tagttctcta atacgcgaac gcagtgcatc aacttcttgc 8160
gtgtcttcct ggttgcgtgt acattcatcg agtctagatt cgagatctct aacgcgtcgt 8220
cgttcttcct caagttctct gcgtactaca gaaagcgtgt ccctatcttg ttgatattta 8280
gcaatttctg attctagagt actgattttg cttacgtagt tactaatagt tgtcttggcc 8340
ttatcaagat cctccttgta tttgtcgcat tccttgatat ccctacgaag tctggacagt 8400
tcccattcga cattacgacg tttatcgatt tcagctcgga gatcgtcatc gcgttgtttt 8460
agccacatac gactgagttc aagttctcgt tgacaagatc catctacttt tccattccta 8520
atagtatcca gttccttttc tagttctgaa cgcatttctc gttccctatc aagcgattct 8580
ctcaattctc ggatagtctt cttatcaatt tctaataaat ctgaaccatc atctgtccca 8640
ttttgaatat ccctgtgttc tttgatctct tttgtaagtc ggtcgattct ttcggtttta 8700
taaacagaat ccctttccaa agtcctaatc ttactgagtt tatcactaag ttctgcattc 8760
aattcggtga gttttctctt ggcttcttcc aactctgttt taaactctcc actatttccg 8820
cattcttcct cgcatttatc taaccattca attagtttat taataactag ttggtaatca 8880
gcgattccta tagccgttct tgtaattgtg ggaacataat taggatcttc taatggattg 8940
tatggcttga tagcatcatc tttatcatta ttagggggat ggacaacctt aattggttgg 9000
tcctcatctc ctccagtagc gtgtggttct tcaataccag tgttagtaat aggcttaggc 9060
aaatgcttgt cgtacgcggg cacttcctca tccatcaagt atttataatc gggttctacg 9120
tctgaatatt cttttctaag agacgcgact tcgggagtta gtagaagaac tctgtttctg 9180
tatctatcaa cgctggaatc aatactcaag ttaaggatag cgaatacctc atcgtcatca 9240
tccgtatctt ctgaaacacc atcatatgac atttcatgaa gtctaacgta ttgataaata 9300
gaatcagatt tagtattaaa cagatcctta acctttttag taaacgcata tgtatatttt 9360
agatctccag atttcataat atgatcacat gccttaaatg tcagtgcttc catgatataa 9420
tctggaacac taatgggtga cgaaaaagat acagcaccat atgctacgtt gataaataaa 9480
tctgaaccac taagtagata atgattaatg ttaaggaaga ggaaatattc agtatataga 9540
tatgccttag catcatatct tgtactaaac acgctaaaca gtttattgat gtgatcaatt 9600
tccaacagaa taattagagc agcgggaata ccaacaaaca tattaccaca tccgtatttt 9660
ctatgaatat cacatatcat gttaaaaaat cttgatagaa gagcgaatat ctcgtctgac 9720
ttaatgagtc gtagttcagc agcaacataa gtcataactg taaatagaac atactttcct 9780
gtagtgttga ttctagactc cacatcaaca ccattattaa aaatagtttt atatacatct 9840
ttaatctgct ctccgttaat cgtcgaacgt tctagtatac ggaaacactt tgatttctta 9900
tctgtagtta atgacttagt gatatcacga agaatattac gaattacatt tcttgttttt 9960
cttgagagac ctgattcaga actcaactca tcgttccata gtttttttac ctcagtggcg 10020
aaatctttgg agtgcttggt acatttttca ataaggttcg tgacctccat ttattataaa 10080
aaattttatt caaaacttaa ctacaatcgg gtaattataa aatcgtagat ctcccatgtg 10140
gtggaatact accatctatc gcatgtggat ggacagtagg taatggccat gggaacagta 10200
atgtttgcat atttatcttt cttgccagta ttactgcata ttgtcccaat gtttcgatgt 10260
gatgttctaa cctatcaact gccgctgtat cacaacaata gtgtccgatg aaattaagat 10320
tatgatccaa tgtgtttaat atatgattat caagtcttat acgatccgcg tcttttttga 10380
caggatcagg ttcttctaca ggaagaagtt tcggcctctt atgatattca tgtctgggaa 10440
acggtggtct agggtgaggc tccggtatcg gagtgggttt tggattataa tcatcatcgt 10500
ctatgacatc atcttcgact tcgatattta ttttgctatc ttgatgatgt cctgtatcag 10560
ttgcattttc agcactcgac tgaatattag cgcattcatt gtctattatt accatatttc 10620
taaacccaaa atgtatgtgt tgaacatcag tactatcgtt gatgagtctt atagcatgaa 10680
ttcgcttatc gttatcgggt ttatcttctg tcaccttagc aattcctttt ttattaaact 10740
ctacataatc atatccattt ctattgtttg ttctaatata aacgagtata gcatcattgc 10800
taaatttttc aatagtatcg aaaacagaat atcctaaacc atataatata tattcaggga 10860
cactcaaact aaatgtccag gattctccta aatacgtaaa ctttaatagt gcgaaatcat 10920
tcaaaaatct accacttata gatagatagt acataaatgc gtatagtagt ctacctatct 10980
ctttattatg aaaaccggca ttacgatcat atatgtcgtg atatacctgt gatccgttta 11040
cgttaaacca taaatacatg ggtgatccta taaacatgaa tttatttcta attctcagag 11100
ctatagttaa ttgaccgtgt aatatttgct tacatgcata cttgatacgc tcattaataa 11160
aatttttatc attgctcgtt atctcagaat cgtatatata aggagtacca tcgtgattct 11220
taccagatat tatacaaaat actatatata aaatatattg accaacgtta gtaatcatat 11280
aaatgtttaa cgttttaaat tttgtattca atgatccatt atcatacgct agcatggtct 11340
tatgatattc attctttaaa atataatatt gtgttagcca ttgcattggg gctcctaatg 11400
gagatttttt attctcatcc attttaggat aggctttcat aaagtcccta ataacttcgt 11460
gaataatgtt tctatgtttt ctactgatgc atgtatttgc ttcgattttt ttatcccatg 11520
tttcatctat catagattta aacgcagtaa tgctcgcaac attaacatct tgaaccgttg 11580
gtacaattcc gttccataaa tttataatgt tcgccattta tataactcat tttttgaata 11640
tacttttaat taacaaaaga gttaagttac tcatatgggc gccgtccagt ctgaacatca 11700
atctttttag ccagagatat catagccgct cttagagttt cagcgtgatt ttccaaccta 11760
aatagaactt catcgttgcg tttacaacac ttttctattt gttcaaactt tgttgttaca 11820
ttagtaatct ttttttccaa attagttagc cgttgtttga gagtttcctc attgtcgtct 11880
tcatcggctt taacaattgc ttcgcgttta gcctctggct ttttagcagc ctttgtagaa 11940
aaaaattcag ttgctggaat tgcaagatcg tcatctccgg ggaaaagagt tccgtccatt 12000
taaagtacag attttagaaa ctgacactct gcgttattta tatttggtac aacacatgga 12060
ttataaatat cgatgttaat aacatcagaa aatgtaaagt ctatacattg ttgcatcgtg 12120
ttaaattttc taatggatct agtattattg ggtccaactt ctgcctgaaa tccaaatatg 12180
gaagcggata caaaaccgtt tcctggataa accacacatc tccacttttg ctttacatca 12240
gaaattgtgt cgttgacatc ttgaactctc ctatctaatg ccggtgttcc acctatagat 12300
tttgaatatt cgaatgctgc atgagtagca ttaaattcct taatattgcc ataattttca 12360
tatattgagt aaccctggat aaaaagtaaa cacaccgcag ccgtcgctac cacaataaaa 12420
aaaattgata gagagttcat ttataatcta ttagaagctg acaaaatttt tttacacgca 12480
tcagacaatg ctttaataaa tagttcaaca tctacttttg tcatatcgaa ccgatggtat 12540
gattctaacc tagaattaca tccgaaaaag ttgactatgt tcatagtcat taagtcatta 12600
acaaacaaca ttccagactc tggattataa gacgatactg tttcgtcaca attacctacc 12660
ttaatcatgt gattatgaat attggctatt agagcacctt ctaagaaatc tataatatct 12720
ttgaaacacg atttaaaatc aaaccacgaa tatacttcta cgaagaaagt tagtttaccc 12780
ataggagaaa taactataaa tggagatcta aatacaaaat ccggatctat gatagtttta 12840
acattattat attctctatt aaatacctcc acatctaaaa atgttaattt tgaaactatg 12900
tcttcgttta ttaccgtacc tgaactaaac gctataagct ctattgtttg agaactcttt 12960
aaacgatatt cttgaaatac atgtaacaaa gtttccttta actcggtcgg tttatctacc 13020
atagttacag aatttgtatc cttatctata atataataat caaaatcgta taaagttata 13080
taattatcgc gttcagattg ggatcttttc aaatagacta aaaaccccat ttctctagta 13140
agtatcttat gtatatgttt gtaaaatatc ttcatggtgg gaatatgctc taccgcagtt 13200
agccattcct cattgacagc ggtagatgta ttagacaaaa ctattccaat gtttaacaag 13260
ggccatttta cgagattatt aaatccttgt ttgataaatg tagccaatga gggttcgagt 13320
tcaacgacga ttgaattctc ttcccgcgga tgctgcatga tgaacgacgg gatgttgttc 13380
gattgatttg gaattctttt tcgacttttt gtttatatta aatattttaa aatttatagc 13440
ggatagcaat tcatgtacca cggataatgt agacgcgtat tgcgcatcga tatctttatt 13500
attagataaa tttatcaata aatgtgagaa gtttgcctcg ttaaggtctt ccatttaaat 13560
attatataaa catttgtgtt tgtatcttat tcgtctttta tggaatagtt ttttactagt 13620
aaagctgcaa ttacacactt tgtccgtaaa acataaatat aaacaccagc ttttatcaat 13680
cgttccaaaa agtcgacggc ggacattttt aacatggcat ctattttaaa tacacttagg 13740
tttttggaaa aaacatcatt ttataattgt aacgattcaa taactaaaga aaagattaag 13800
attaaacata agggaatgtc atttgtattt tataagccaa agcattctac cgttgttaaa 13860
tacttgtctg gaggaggtat atatcatgat gatttggttg tattggggaa ggtaacaatt 13920
aataatctaa agatgatgct attttacatg gatttatcat atcatggagt gacaagtagt 13980
ggagcaattt acaaattggg atcgtctatc gatagacttt ctctaaatag gactattgtt 14040
acaaaagtta ataattatga tgatacattt tttgacgacg atgattgatc gctattgcac 14100
aattttgttt ttttactttc taatatagcg tttagattct ttttcatgtg cgaatattga 14160
tttactaaaa tatcgatgtt taacttttgt tctatgacgt ccttatcagc ggtatcggta 14220
catatacgta attcaccttc acaaaatacg gagtcttcga taataatagc caatcgatta 14280
ttggatctag ctgtctgtat catattcaac atgtttaata tatcctttcg tttccccttt 14340
acaggcatcg atcgtagcat attttccgcg tctgagatgg aaatgttaaa actacaaaaa 14400
tgcgtaatgt tagcccgtcc taatattggt acgtgtctat aagtttggca tagtagaata 14460
atagacgtgt ttaaatgcct tccaaagttt aagaattcta ttagagtatt gcattttgat 14520
agtttatcac ctacatcatc aaaaataagt aaaaagtgtg ctgatttttt atgattttgt 14580
gcgacagcaa tacatttttc tatgttactt ttagttcgta tcagattata ttctagagat 14640
tcctgactac taacgaaatt aatatgattt ggccaaatgt atccatcata atctgggtta 14700
taaacgggtg taaacaagaa tatatgttta tattttttaa ctagtgtaga aaacagagat 14760
agtaaataga tagtttttcc agatccagat cctcccgtta aaaccattct aaacggcatt 14820
tttaataaat tttctcttga aaattgtttt tcttggaaac aattcataat tatatttaca 14880
gttactaaat taatttgata ataaatcaaa atatggaaaa ctaaggtcgt tagtagggag 14940
gagaacaaag aaggcacatc gtgacataaa taacatttat tatcatgatg acaccagaaa 15000
acgacgaaga gcagacatct gtgttctccg ctactgttta cggagacaaa attcaaggaa 15060
agaataaacg caaacgcgtg attggtctat gtattagaat atctatggtt atttcactac 15120
tatctatgat taccatgtcc gcgtttctca tagtgcgcct aaatcaatgc atgtctgcta 15180
acgaggctgc tattactgac gccgctgttg ccgttgctgc tgcatcatct actcatagaa 15240
aggttgcgtc tagcactaca caatatgatc acaaagaaag ctgtaatggt ttatattacc 15300
agggttcttg ttatatatta cattcagact accagttatt ctcggatgct aaagcaaatt 15360
gcactgcgga atcatcaaca ctacccaata aatccgatgt cttgattacc tggctcattg 15420
attatgttga ggatacatgg ggatctgatg gtaatccaat tacaaaaact acatccgatt 15480
atcaagattc tgatgtatca caagaagtta gaaagtattt ttgtgttaaa acaatgaact 15540
aatatttatt tttgtacatt aataaatgaa atcgcttaat agacaaactg taagtaggtt 15600
taagaagttg tcggtgccgg ccgctataat gatgatactc tcaaccatta ttagtggcat 15660
aggaacattt ctgcattaca aagaagaact gatgcctagt gcttgcgcca atggatggat 15720
acaatacgat aaacattgtt atttagatac taacattaaa atgtctacag ataatgcggt 15780
ttatcagtgt cgtaaattac gagccagatt gcctagaccg gatactagac atctgagagt 15840
attgtttagt attttttata aagattattg ggtaagttta aaaaagacca atgataaatg 15900
gttagatatt aataatgata aagatataga tattagtaaa ttaacaaatt ttaaacaact 15960
aaacagtacg acggatgctg aagcgtgtta tatatacaag tctggaaaac tggttaaaac 16020
agtatgtaaa agtactcaat ctgtactatg tgttaaaaaa ttctacaagt gacaacaaaa 16080
aatgaattaa taataagtcg ttaacgtacg ccgccatgga cgccgcgttt gttattactc 16140
caatgggtgt gttgactata acagatacat tgtatgatga tctcgatatc tcaatcatgg 16200
actttatagg accatacatt ataggtaaca taaaaactgt ccaaatagat gtacgggata 16260
taaaatattc cgacatgcaa aaatgctact ttagctataa gggtaaaata gttcctcagg 16320
attctaatga tttggctaga ttcaacattt atagcatttg tgccgcatac agatcaaaaa 16380
ataccatcat catagcatgc gactatgata tcatgttaga tatagaagat aaacatcagc 16440
cattttatct attcccatct attgatgttt ttaacgctac aatcatagaa gcgtataacc 16500
tgtatacagc tggagattat catctaatca tcaatccttc agataatctg aaaatgaaat 16560
tgttgtttaa ttcttcattc tgcatatcag acggcaatgg atggatcata attgatggga 16620
aatgcaatag taatttttta tcataaaagt tgtaaagtaa ataataaaac aataaatatt 16680
gaactagtag tacgtatatt gagcaatcag aaatgatgct ggtacctctt atcacggtga 16740
ccgtagttgc gggaacaata ttagtatgtt atatattata tatttgtagg aaaaagatac 16800
gtactgtcta taatgacaat aaaattatca tgacaaaatt aaaaaagata aagagttcta 16860
attccagcaa atctagtaaa tcaactgata gcgaatcaga ctgggaggat cactgtagtg 16920
ctatggaaca aaacaatgac gtagataata tttctaggaa tgagatattg gacgatgata 16980
gcttcgctgg tagtttaata tgggataacg aatccaatgt catggcgcct agcacagaac 17040
acatttacga tagtgttgct ggaagcacgc tgctaataaa taatgatcgt aatgaacaga 17100
ctatttatca gaacactaca gtagtaatta atgagacgga gactgttgaa gtacttaatg 17160
aagataccaa acagaatcct aactattcat ccaatccttt cgtaaattat aataaaacca 17220
gtatttgtag caagtcaaat ccgttcatta cagaactcaa caataaattt agtgagaata 17280
atccgtttag acgagcacat agcgatgatt atcttaataa gcaagaacaa gatcatgaac 17340
acgatgatat agaatcatcg gtcgtatcat tggtgtgatt agtttccttt ttataaaatt 17400
gaagtaatat ttagtattat tgctgccgtc acgttgtaca aatggagata ttccctgtat 17460
tcggcatttc taaaattagc aattttattg ctaataatga ctgtagatat tatatagata 17520
cagaacatca aaaaattata tctgatgaga tcaatagaca gatggatgaa acggtacttc 17580
ttaccaacat cttaagcgta gaagttgtaa atgacaatga gatgtaccat cttattcccc 17640
atagactatc gactattata ctctgtatta gttctgtcgg aggatgtgtt atctctatag 17700
ataatgacat caatgacaaa aatattctaa catttcccat tgatcatgct gtaatcatat 17760
ccccactgag taaatgtgtc gtagttagca agggtcctac aaccatattg gttgttaaag 17820
cggatatacc cagcaaacga ttggtaacat cgtttacaaa cgacatactg tatgtaaaca 17880
atctgtcact gattaattat ttgccgttgt ctgtattcat tattagacga gtcaccgact 17940
atttggatag acacatatgc gatcagatat ttgcgaataa taagtggtat tccattataa 18000
ccatcgacga taagcaatat cctattccat caaactgtat aggtatgtcc tctgccaagt 18060
acataaattc tagcatcgag caagatactt taatacatgt ttgtaacctc gagcatccat 18120
tcgacttagt atacaaaaaa atgcagtcgt acaattctgt acctatcaag gaacaaatat 18180
tgtacggtag aattgataat ataaatatga gcattagtat ttctgtggat taatagattt 18240
ctagtatggg gatcattaat catctctaat ctctaaatac ctcataaaac gaaaaaaaag 18300
ctattatcaa atactgtacg gaatggattc attctcttct ctttttatga aactctgttg 18360
tatatctact gataaaactg gaagcaaaaa atctgataaa aagaataaga ataagatcaa 18420
ggattatatg gaacacgatt attataaaat aacaatagtt cctggttcct cttccacgtc 18480
tactagctcg tggtattata cacatgccta gtaatagtct ctttgcgttg acggaaagca 18540
gactagaaat aacaggctaa aatgttcaga caccataata gttcccaacc cagataataa 18600
cagagtacca tcaacacatt cctttaaact caatcccaaa cccaaaaccg ttaaaatgta 18660
tccggccaat tgatagtaga taatgaggtg tacagcgcat gataatttac acagtaacca 18720
aaatgaaaat actttagtaa ttataagaaa tatagatggt aacgtcatca tcaacaatcc 18780
aataatatgc cggagagtaa acattgacgg ataaaacaaa aatgctccgc ataactctat 18840
catggcaata acacaaccaa atacttgtaa gattcctaaa ttagtagaaa atacaacgga 18900
tatcgatgta taagtgatct cgagaaataa taagaataaa gtaatgcccg taaagataaa 18960
catcaacatt gtttggtaat cattaaacca attagtatga agttgaacta atttcacagt 19020
agattttatt ccagtgttat cctcgcatgt atacgtacct ggtaagatat ctttatattc 19080
tataatcaat gagacatcac tatccgataa cgaatgaagt ctagcactag tatgccattt 19140
acttaatatg gtcgtcttgg aagttttatt ataagttaaa atatcatggt tgtccaattt 19200
ccatctaata tactttgtcg gattatctat agtacacgga ataatgatgg tattattaca 19260
tgctgtatac tctatagtct ttgtagatgt tataatcata aaagtacaga ggtatatcaa 19320
cgatattcta actcttgaca ttttttattt atttaaaatg atacctttgt tatttatttt 19380
attctatttt gctaacggta tcgaatggca taagtttgaa acgagtgaag aaataatttc 19440
tacttactta ttagacgacg tattatacac gggtgttaat ggggcggtat acacattttc 19500
aaataataaa ctaaacaaaa ctggtttagc taatactaat tatatcacaa catctataaa 19560
agtagaggat gcggataagg atacattagt atgcggaacc aataacggaa atcccaaatg 19620
ttggaaaata gacggttcag acgacccaaa acatagaggt agaggatacg ctccttatca 19680
aaatagcaaa gtaacgataa tcagtcacaa cggatgtgta ctatctgaca taaacatatc 19740
aaaagaagga attaaacgat ggagaagatt tgacggacca tgtggttatg atttatacac 19800
ggcggataac gtaattccaa aagatggttt acgaggagca ttcgtcgata aagatggtac 19860
ttatgacaaa gtttacattc ttttcactga tactatcggc tcaaagagaa ttgtcaaaat 19920
tccgtatata gcacaaatgt gcctaaacga cgaaggtggt ccatcatcat tgtctagtca 19980
tagatggtcg acgtttctca aagtcgaatt agaatgtgat atcgacggaa gaagttatag 20040
acaaattatt cattctagaa ctataaaaac agataatgat acgatactat atgtattctt 20100
cgatagtccg cattatgtac ctattctatg aataccatta aacaatcttt ttctacgtca 20160
aaattggaag gatatacaaa gcaattgccg tctccagctc ctggtatatg tctaccagct 20220
ggaaaagttg ttccacatac cacgtttgaa gtcatagaaa aatataatgt actagatgat 20280
attataaagc ctttatctaa ccaacctatc ttcgaaggac cgtctggtgt taaatggttc 20340
gatataaagg agaaggaaaa tgaacatcgg gaatatagaa tatacttcat aaaagaaaat 20400
tctatatatt cgttcgatac aaaatctaaa caaactcgta gctcgcaagt cgatgcgcga 20460
ctattttcag taatggtaac ttcgaaaccg ttatttatag cagatatagg gataggagta 20520
ggaatgccac aaatgaaaaa aatacttaaa atgtaatctt aatcgagtac accacacgac 20580
aatgaacaaa cataagacag attatgctgg ttatgcttgc tgcgtaatat gcggtctaat 20640
tgttggaatt atttttacag cgacactatt aaaagttgta gaacgtaaat tagttcatac 20700
accatcaata gataaaacga taaaagatgc atatattaga gaagattgtc ctactgactg 20760
gataagctat aataataaat gtatccattt atctactgat cgaaaaacct gggaggaagg 20820
acgtaatgca tgcaaagctc taaatccaaa ttcggatcta attaagatag agactccaaa 20880
cgagttaagt tttttaagaa gcattagacg cggatattgg gtaggagaat ccgaaatatt 20940
aaaccagaca accccatata attttatagc taagaatgcc acgaagaatg gaactaaaaa 21000
acggaaatat atttgtagca caacgaatac tcccaaactg cattcgtgtt acactatata 21060
acaattacac tacattttta tcataccact acttcggtta gatgttttag aaaaaaataa 21120
atatcgccgt accgttcttg tttttataaa aataacaatt aacaattatc aaattttttc 21180
tttaatattt tacgtggttg accattcttg gtggtaaaat aatctcttag tgttggaatg 21240
gaatgctgtt taatgtttcc acactcatcg tatattttga cgtatgtagt cacatcgttt 21300
acgcaatagt cagactgtag ttctatcatg cttcctacat tagaaggagg aacagtttta 21360
aagtctcttg gttttaatct attaccgtta gttttcatga aatcctttgt tttatccact 21420
tcacatttta aataaatgtc cactatacat tcttctgtta attttactag atcgtcatgg 21480
gtcatagaat ttataggttc cgtagtccat ggatccaaac tagcaaactt cgcgtatacg 21540
gtatcgcgat tagtgtatac accaactgta tgaaaattaa gaaaacagtt taatagatca 21600
acagaaatat ttaatcctcc gtttgataca gatgcaccat atttatggat tttggattca 21660
cacgttgttt gtctgagggg ttcgtctagc gttgcttcta cataaacttc tattcccata 21720
tattctttat tgtcagaatc gcataccgat ttatcatcat acactgtttg aaaactaaat 21780
ggtatacaca tcaaaataac aaatactaac gagtacattc tgcaatattg ttatcgtaat 21840
tggaaaaata gtgttcgagt gagttggatt atgtgagtat tggattgtat attttatttt 21900
atattttgta ataagaataa aatgctaatg tcaagtttat tccaatagat gtcttattaa 21960
aaacatatat aataaataac aatggctgaa tggcataaaa ttatcgagga tatctcaaaa 22020
aataataagt tcgaggatgc cgccatcgtt gattacaaga ctacaaagaa tgttctagct 22080
gctattccta acagaacatt tgccaagatt aatccgggtg aaattattcc tctcatcact 22140
aatcgtaata ttctaaaacc tcttattggt cagaaatatt gtattgtata tactaactct 22200
ctaatggatg agaacacgta tgctatggag ttgcttactg ggtacgcccc tgtatctccg 22260
atcgttatag cgagaactca taccgcactt atatttttga tgggtaagcc aacaacatcc 22320
agacgtgacg tgtatagaac gtgtagagat cacgctaccc gtgtacgcgc aactggtaat 22380
taaaataaaa agtaatattc atatgtagtg tcaattttaa atgatgatga tgaaatggat 22440
aatatccata ttgacgatgt caataatgcc ggtattggca tacagctcat cgatttttag 22500
atttcattca gaggatgtgg aattatgtta tgggcatttg tattttgata ggatctataa 22560
tgtagtaaat ataaaatata atccgcatat tccatataga tataatttta ttaatcgcac 22620
gttaaccgta gatgaactag acgataatgt cttttttaca catggttatt ttttaaaaca 22680
caaatatggt tcacttaatc ctagtttgat tgtctcatta tcaggaaact taaaatataa 22740
tgatatacaa tgctcagtaa atgtatcgtg tctcattaaa aatttggcaa cgagtacatc 22800
tactatatta acatctaaac ataagactta ttctctacat cggtccacgt gtattactat 22860
aataggatac gattctatta tatggtataa agatataaat gacaagtata atggcatcta 22920
tgattttact gcaatatgta tgctaatagc gtctacattg atagtgacca tatacgtgtt 22980
taaaaaaata aaaatgaact cttaattatg ctatgctatt agaaatggat aaaatcaaaa 23040
ttacggttga ttcaaaaatt ggtaatgttg ttaccatatc gtataacttg gaaaagataa 23100
ctattgatgt cacacctaaa aagaaaaaag aaaaggatgt attattagcg caatcagttg 23160
ctgtcgaaga ggcaaaagat gtcaaggtag aagaaaaaaa tattatcgat attgaagatg 23220
acgatgatat ggatgtagaa agcgcataat acgatctata aaaataagta tataaatact 23280
ttttatttac tgtactctta ctgtgtagtg gtgataccct actcgattat ttttttaaaa 23340
aaatacttat tctgattctt ctagccattt ccgtgttcgt tcgaatgcca catcgacgtt 23400
aaagataggg gagtagttga aatctagttc tgcattgttg gtacgcacct caaatgtagt 23460
gttggatatc ttcaacgtat agttgttgag tagtgatggt tttctaaata gaattctctt 23520
catatcattc ttgcacgcgt acatttttag catccatctt ggaattctag atccttgttc 23580
tattcccaat ggtttcatca atagaagatt aaacatatcg tacgaacacg atggagagta 23640
atcgtagcaa aagtaagcat ttcctttaat ctcagatccc ggatactgga tatattttgc 23700
agccaacacg tgcatccatg caacatttcc tacatatacc cggctatgca ccgcgtcatc 23760
atcgactgta cgatacataa tgttaccgtg ttgcttacat tgctcgtaaa agactttcgt 23820
caatttgtct ccttctccgt aaattccagt gggtcttagg caacaagtat acaattttgc 23880
tccattcatg attacggaat tattggcttt cataaccagt tgctcggcca tacgtttact 23940
ttttgcgtat acatgtcctg gtgatatatc ataaagggta tgctcatggc cgatgaatgg 24000
atcaccgtgt ttatttggtc ctattgcttc catgctacta gtatagatca aatacttgat 24060
tcctaggtcc acacaagctg ccaatatagt ctgtgttcca taatagttta ctttcatgat 24120
ttcattatcg gtgtattttc caaatacatc cactagagca gccgtatgaa taatcagatt 24180
taccccatct agcgcttctc tcaccttatc aaagtcgttt atatcacatt gtatatagtt 24240
tataacctta actttcgagg ttattggttg tggatcttct acaatatcta tgactctgat 24300
ttcttgaaca tcatctgcac taattaacag ttttactata tacctgccta gaaatccggc 24360
accaccagta accgcgtaca cggccattgc tgccactcat aatatcagac tacttattct 24420
attttactaa ataatggctg tttgtataat agaccacgat aatatcagag gagttattta 24480
ctttgaacca gtccatggaa aagataaagt tttaggatca gttattggat taaaatccgg 24540
aacgtatagt ttgataattc atcgttacgg agatattagt caaggatgtg attccatagg 24600
cagtccagaa atatttatcg gtaacatctt tgtaaacaga tatggtgtag catatgttta 24660
tttagataca gatgtaaata tatctacaat tattggaaag gcgttatcta tttcaaaaaa 24720
tgatcagaga ttagcgtgtg gagttattgg tatttcttac ataaatgaaa agataataca 24780
ttttcttaca attaacgaga atggcgtttg atatatcagt taatgcgtct aaaacaataa 24840
atgcattagt ttacttttct actcagcaaa ataaattagt catacgtaat gaagttaatg 24900
atacacacta cactgtcgaa tttgataggg acaaagtagt tgacacgttt atttcatata 24960
atagacataa tgacaccata gagataagag gggtgcttcc agaggaaact aatattggtt 25020
gcgcggttaa tacgccggtt agtatgactt acttgtataa taagtatagt tttaaactga 25080
ttttagcaga atatataaga cacagaaata ctatatccgg caatatttat tcggcattga 25140
tgacactaga tgatttggct attaaacagt atggagacat tgatctatta tttaatgaga 25200
aacttaaagt agactccgat tcgggactat ttgactttgt caactttgta aaggatatga 25260
tatgttgtga ttctagaata gtagtagctc tatctagtct agtatctaaa cattgggaat 25320
tgacaaataa aaagtatagg tgtatggcat tagccgaaca tatatctgat agtattccaa 25380
tatctgagct atctagacta cgatacaatc tatgtaagta tctacgcgga cacactgaga 25440
gcatagagga taaatttgat tattttgaag acgatgattc gtctacatgt tctgccgtaa 25500
ccgacaggga aacggatgta taattttttt tatagcgtga aggatatgat aaaaaatata 25560
attgttgtat ttatcccatt ccaatcacct tatatgattc tgtaacacaa tgaaggagtc 25620
tcatagatgt atagaggtca gatactggtt tgataaactg tttattccac atgagtatgt 25680
ttgactttat ggttagaccc gcatacttta acaaatcact gaaaattgga gttaggtatt 25740
gacctctcag aatcagttgc cgttctggaa cattaaatgt attttttatg atatactcca 25800
acgcatttat gtgggcatac aacaagtcat tactaatgga gtattccaag agttttagtt 25860
gtctagtatt taacaagaga agagatttca acagactgtt tatgaactcg aatgccgcct 25920
cattgtcgct tatattgatg atgtcgaatt ctcccaatat catcaccgat gagtagctca 25980
tcttgttatc gggatccaag ttttctaaag atgtcattaa accctcgatc atgaatggat 26040
ttatcatcat cgtttttatg ttggacatga gcttagtccg tttgtccaca tctatagacg 26100
acgatttctg aattatttta tatatccctc tctttaactc caggaacttg tcaggatggt 26160
ctactttaat atgttctcgt ctaagagatg aaaatctttg gatggttgca cgcgactttt 26220
ctctaaagga tgacgttgcc caagatcctc tcttaaatga atccatctta tccttggaca 26280
agatggacag tctattttcc ttagatggtt taatattttt gttacccatg atctataaag 26340
gtagacctaa tcgtctcgga tgacctatat atttattttc agttttatta tacgcataaa 26400
ttgtaaaaaa tatgttaggt ttacaaaaat gtctcgtggg gcattaatcg tttttgaagg 26460
attggacaaa tctggaaaaa caacacaatg tatgaacatc atggaatcta taccggcaaa 26520
cacgataaaa tatcttaact ttcctcagag atccactgtc actggaaaga tgatagatga 26580
ctatctaact cgtaaaaaaa cctataatga tcatatagtt aatctattat tttgtgcaaa 26640
tagatgggag tttgcatctt ttatacaaga acaactagaa cagggaatta ctttaatagt 26700
tgatagatac gcgttctctg gagtagcgta tgccgccgct aaaggcgcgt caatgactct 26760
cagtaagagt tatgaatctg gattgcctaa acccgactta gttatattct tggaatctgg 26820
tagcaaagaa attaatagaa acgtcggcga ggaaatttat gaagatgtta cattccaaca 26880
aaaggtatta caagaatata aaaaaatgat tgaagaagga gatattcatt ggcaaattat 26940
ttcttctgaa ttcgaggaag atgtaaagaa ggagttgatt aagaatatag ttatagaggc 27000
tatacacacg gttactggac cagtggggca actgtggatg taatagtgaa attacatttt 27060
ttataaatag atgttagtac agtgttataa atggatgaag catattactc tggcaacttg 27120
gaatcagtac tcggatacgt gtccgatatg cataccgaac tcgcatcaat atctcaatta 27180
gttattgcca agatagaaac tatagataat gatatattaa acaaggacat tgtaaatttt 27240
atcatgtgta gatcaaactt ggataatcca tttatctctt tcctagatac tgtatatact 27300
attatagatc aagagaacta tcagaccgaa ttgattaatt cattagacga caatgaaatt 27360
atcgattgta tagttaataa gtttatgagc ttttataagg ataacctaga aaatatagta 27420
gatgctatca ttactctaaa atatataatg aataatccag attttaaaac tacgtatgcc 27480
gaagtactcg gttccagaat agccgatata gatattaaac aagtgatacg tgagaatata 27540
ctacaattgt ctaatgatat ccgcgaacga tatttgtgaa aaatattaaa aaaaaatact 27600
ttttttatta aatgacgtcg cttcgcgaat ttagaaaatt atgctgtgat atatatcacg 27660
catcaggata taaagaaaaa tctaaattaa ttagagactt tataacagat agggatgata 27720
aatatttgat cattaagcta ttgcttcccg gattagacga tagaatttat aacatgaacg 27780
ataaacaaat tataaaatta tatagtataa tatttaaaca atctcaggaa gatatgctac 27840
aagatttagg atacggatat ataggagaca ctattaggac tttcttcaaa gagaacacag 27900
aaatccgtcc acgagataaa agcattttaa ctttagaaga cgtggatagt ttcttaacta 27960
cgttatcatc cgtaactaaa gaatcgcatc aaataaaatt attgactgat atcgcatccg 28020
tttgtacatg taatgattta aaatgtgtag tcatgcttat tgataaagat ctaaaaatta 28080
aagcgggtcc tcggtacgta cttaacgcta ttagtcctaa tgcctatgat gtgtttagaa 28140
aatctaataa cttgaaagag ataatagaaa atgcatctaa acaaaatcta gactctatat 28200
ctatttctgt tatgactcca attaatccca tgttagcgga atcgtgtgat tctgtcaata 28260
aggcgtttaa aaaatttcca tcaggaatgt ttgcggaagt caaatacgat ggtgaaagag 28320
tacaagttca taaaaataat aacgagtttg ccttctttag tagaaacatg aaaccagtac 28380
tctctcataa agtggattat ctcaaagaat acataccgaa agcatttaaa aaagctacgt 28440
ctatcgtatt ggattctgaa attgttcttg tagacgaaca taatgtaccg ctcccgtttg 28500
gaagtttagg aatacacaaa aagaaagaat ataaaaactc taacatgtgt ttgttcgtgt 28560
ttgactgttt gtactttgat ggattcgata tgacggacat tccattgtac gaacgaagat 28620
cttttctcaa agatgttatg gttgaaatac ccaatagaat agtattctca gagttgacga 28680
atattagtaa cgagtctcag ttaactgacg tattggatga tgcactaacg agaaaattag 28740
aaggattggt cttaaaagat attaatggag tatacgaacc gggaaagaga agatggttaa 28800
aaataaagcg agactatttg aacgagggtt ccatggcaga ttctgccgat ttagtagtac 28860
taggtgctta ctatggtaaa ggagcaaagg gtggtatcat ggcagtcttt ctaatgggtt 28920
gttacgacga tgaatccggt aaatggaaga cggttaccaa gtgttcagga cacgatgata 28980
atacgttaag ggttttgcaa gaccaattaa cgatggttaa aattaacaag gatcccaaaa 29040
aaattccaga gtggttggta gttaataaaa tctatattcc cgattttgta gtagaggatc 29100
cgaaacaatc tcagatatgg gaaatttcag gagcagagtt tacatcttcc aagtcccata 29160
ccgcaaatgg aatatccatt agatttccta gatttactag gattagagaa gataaaacgt 29220
ggaaagaatc tactcatcta aacgatttag taaacttgac taaatcttaa tagttacata 29280
caaactgaaa attaaaataa cactatttag ttggtggtcg ccatggatgg tgttattgta 29340
tactgtctaa acgcgttagt aaaacatggc gaggaaataa atcatataaa aaatgatttc 29400
atgattaaac catgttgtga aagagtttgt gaaaaagtca agaacgttca cattggcgga 29460
caatctaaaa acaatacagt gattgcagat ttgccatata tggataatgc ggtatccgat 29520
gtatgcaatt cactgtataa aaagaatgta tcaagaatat ccagatttgc taatttgata 29580
aagatagatg acgatgacaa gactcctact ggtgtatata attattttaa acctaaagat 29640
gttattcctg ttatcatatc tataggaaag gataaagatg tctgtgaact attaatctca 29700
tcagacatat cgtgtgcatg cgtggagtta aattcatatc acgtagccat tcttcccatg 29760
gatgtttcct tttttaccaa aggaaatgca tcattgatta ttctcctgtt tgatttctct 29820
atcgatgcag cacctctctt aagaagtgta accgataata atgttattat atctagacac 29880
cagcgtctac atgacgagct tccgagttcc aattggttca agttttacat aagtataaag 29940
tccgactatt gttctatatt atatatggtt gttgatggat ctgtgatgca tgcgatagct 30000
gataatagaa ctcacgcaat tattagcaaa aatatattag acaatactac gattaacgat 30060
gagtgtagat gctgttattt tgaaccacag attaggattc ttgatagaga tgagatgctc 30120
aatggatcat cgtgtgatat gaacagacat tgtattatga tgaatttacc tgatgtaggc 30180
aaatttggat ctagtatgtt ggggaaatat gaacctgaca tgattaagat tgctctttcg 30240
gtggctggta atttaataag aaatcgagac tacattcccg ggagacgagg atatagctac 30300
tacgtttacg gtatagcctc tagataattt ttttaagcac gaaataaaaa acataatttt 30360
aaaccaatct atttcatact attttgtgtg atcaccatgg acataaagat agatattagt 30420
atttctggtg ataaatttac ggtgactact aggagggaaa atgaagaaag aaaaaaatat 30480
ctacctctcc aaaaagaaaa aactactgat gttatcaaac ctgattatct tgagtacgat 30540
gacttgttag atagagatga gatgtttact attctagagg aatattttat gtacagaggt 30600
ctattaggcc tcagaataaa atatggacga ctctttaacg aaattaaaaa attcgacaat 30660
gatgcggaag aacaattcgg tactatagaa gaactcaagc agaaacttag attaaattct 30720
gaagagggag cagataactt tatagattat ataaaggtac aaaaacagga tatcgtcaaa 30780
cttactgtat acgattgcat atctatgata ggattgtgtg catgcgtggt agatgtttgg 30840
agaaatgaga aactgttttc tagatggaaa tattgtttac gagctattaa actgtttatt 30900
aatgatcaca tgcttgataa gataaaatct atactgcaga atagactagt atatgtggaa 30960
atgtcataga aagttaaaag ttaatgagag caaaaatata taaggttgta ttccatattt 31020
gttatttttt ctgtaatagt tagaaaaata cattcgatgg tctatctacc agattattat 31080
gtgttataag gtactttttc tcataataaa ctagagtatg agtaagatag tgtttttcaa 31140
aacatataaa tctaaaattg atggatgaga tatacagcta ttaatttcga aaatatattt 31200
taatctgata actttaaaca tggatttttg atggtggttt aacgttttaa aaaaagattt 31260
tgttattgta gtatatgata atattaaaag atggatataa agaatttgct gactgcatgt 31320
actatttttt acattactac attggctacg gcagatatac ctactccgcc accaacgggt 31380
catgtgacaa gggagaatat cttgataaga ggcataatca atgttgtaat cggtgtccac 31440
ctggagaatt tgccaaggtt agatgtaatg gtaacgataa cacaaaatgt gaacgctgcc 31500
cacctcatac atataccaca atcccaatta ttctaatgga tgtcatcaat gtagaaaatg 31560
cccaaccgga tcatttgata aggtaaagtg taccggaaca cagaacagta aatgttcgtg 31620
tcttcctggt tggtattgtg ctactgattc ttcacagact gaagattgtt gaaattgtgt 31680
accaaaaagg agatgtccat gcggatactt tggtggaata gatgaacaag gaaatcctat 31740
ttgtaaatcg tgttgtgttg gtgaatattg cgactaccta cgtaattata gacttgatcc 31800
atttcctcca tgcaaactat ctaaatgtaa ttaattatga ttttgatgat aatgttacca 31860
tacattatat cgctacttgg ttagtgtatt attcagtatg aagacctatt aataattact 31920
tatcttttga cgatcttgtt ataattataa tataaaaata cttatggcat agtaactcat 31980
aattgctgac gcgataaatt cgtaataatc tgttttgttc aaatttttat aaggaatcta 32040
caggcataaa aataaaaata taatttataa tatactctta cagcgcgcca tcatgaataa 32100
cagcagtgaa ttgattgctg ttattaatgg atttagaaat agtggacgat tttgtgatat 32160
tagtatagtt attaatgatg aaaggataaa cgctcataaa ctcatcctat ctggagcctc 32220
cgaatatttt tccattctgt tttccaataa ttttatcgat tctaatgaat acgaagttaa 32280
tctaagtcat ttagattatc aaagcgttaa cgatttgatc gattacattt atgggatacc 32340
tttgagccta actaacgata acgtgaaata tattctttca accgctgatt ttttacaaat 32400
tggatctgct attacggagt gtgaaaatta catacttaaa aatctttgtt ctaaaaactg 32460
tatcgatttc tacatatacg ctgataaata taataacaag aaaatagaat cagcgtcgtt 32520
taacacaata ttacaaaata ttttgagact catcaacgat gaaaacttta aatacttaac 32580
agaggaatca atgataaaaa ttttaagcga tgatatgtta aatataaaaa atgaggattt 32640
tgcaccacta attctcatta aatggttaga gagtactcaa caatcatgca ccgtcgagtt 32700
acttagatgc ctcagaatat cattgctttc cccacaagtt ataaaatcac tttatagtca 32760
tcaactggtt agttcaatct acgaatgtat aacattctta aacaatatag cattcttgga 32820
tgaatcattt cctagatacc atagcatcga gttgatatct atcggtataa gtaattcgca 32880
tgataagatt tccataaact gctacaatca taaaaaaaat acatgggaaa tgatatcttc 32940
acgtagatat aggtgtagtt tcgcagtggc cgtcctggat aatattatct atatgatggg 33000
tggatatgat cagtccccgt atagaagttc aaaggttata gcgtacaata catgtacaaa 33060
ttcttggata tatgatatac cagagctaaa atatcctcgt tctaattgtg ggggactggc 33120
tgatgacgaa tacatttatt gtataggcgg catacgcgat caggattcat cgttgacatc 33180
tagtattgat aaatggaagc catcaaaacc atattggcag aagtatgcta aaatgcgcga 33240
accaaaatgt gatatggggg ttgcgatgtt aaacggatta atatatgtca tgggtggaat 33300
cgttaaaggt gacacgtgta ccgacgcact agagagttta tcagaagatg gatggatgaa 33360
gcatcaacgt cttccaataa aaatgtccaa tatgtcgacg attgttcatg atggcaagat 33420
ttatatatct ggaggttaca acaatagtag tgtagttaat gtaatatcga atctagtcct 33480
tagctataat ccgatatatg atgaatggac caaattatca tcattaaaca ttcctagaat 33540
taatcccgct ctatggtcag cgcataataa attatatgta ggaggaggaa tatctgatga 33600
tgttcgaact aatacatctg aaacatacga taaagaaaaa gattgttgga cattggataa 33660
tggtcacgtg ttaccacgca attatataat gtataaatgc gaaccgatta aacataaata 33720
tccattggaa aaaacacagt acacgaatga ttttctaaag tatttggaaa gttttatagg 33780
tagttgatag aacaaaatac ataattttgt aaaaataaat cactttttat actaatatga 33840
cacgattacc aatacttttg ttactaatat cattagtata cgctacacct tttcctcaga 33900
catctaaaaa aataggtgat gatgcaactc tatcatgtaa tcgaaataat acaaatgact 33960
acgttgttat gagtgcttgg tataaggagc ccaattccat tattctttta gctgctaaaa 34020
gcgacgtctt gtattttgat aattatacca aggataaaat atcttacgac tctccatacg 34080
atgatctagt tacaactatc acaattaaat cattgactgc tagagatgcc ggtacttatg 34140
tatgtgcatt ctttatgaca tcaactacaa atgacactga taaagtagat tatgaagaat 34200
actccacaga gttgattgta aatacagata gtgaatcgac tatagacata atactatctg 34260
gatctacaca ttcaccggaa actagttcta agaaacctga ttatatagat aattctaatt 34320
gctcgtcggt attcgaaatc gcgactccgg aaccaattac tgataatgta gaagatcata 34380
cagacaccgt cacatacact agtgatagca ttaatacagt aagtgcatca tctggagaat 34440
ccacaacaga cgagactccg gaaccaatta ctgataaaga agatcataca gttacagaca 34500
ctgtctcata cactacagta agtacatcat ctggaattgt cactactaaa tcaaccaccg 34560
atgatgcgga tctttatgat acgtacaatg ataatgatac agtaccacca actactgtag 34620
gcggtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa atatttggta 34680
ttaccgcatt aattatattg tcggccgtgg caattttctg tattacatat tatatatata 34740
ataaacgttc acgtaaatac aaaacagaga acaaagtcta gatttttgac ttacataaat 34800
gtctgggata gtaaaatcta tcatattgag cggaccatct ggtttaggaa agacagccat 34860
agccaaaaga ctatgggaat atatttggat ttgtggtgtc ccataccact agatttcctc 34920
gtcctatgga acgagaaggt gttgattacc attacgttaa cagagaggcc atctggaagg 34980
gaatagccgc cggaaacttt ctagaacata ctgagttttt aggaaatatt tacggaactt 35040
ctaaaacagc tgtgaataca gcggctatta ataatcgtat ttgtgtgatg gatctaaaca 35100
tcgacggtgt tagaagtctt aaaaatacgt acctaatgcc ttactcggtg tatataagac 35160
ctacctctct taaaatggtt gagaccaagc ttcgttgtag aaacactgaa gctaacgatg 35220
agattcatcg tcgcgtgata ttggcaaaaa cggatatgga tgaggccaac gaagcaggtc 35280
tattcgacac tattatcatt gaagatgatg tgaatttagc atatagtaag ttaattcaga 35340
tactacagga ccgtattaga atgtatttta acactaatta gagacttaag acttaaaact 35400
tgataattaa taatataact cgtttttata tgtggctatt tcaacgtcta atgtattagt 35460
taaatattaa aacttaccac gtaaaactta aaatttaaaa tgatatttca ttgacagata 35520
gatcacacat tatgaacttt caaggacttg tgttaactga caattgcaaa aatcaatggg 35580
tcgttggacc attaatagga aaaggtggat tcggtagtat ttatactact aatgacaata 35640
attatgtagt aaaaatagag cccaaagcta acggatcatt atttaccgaa caggcatttt 35700
atactagagt acttaaacca tccgttatcg aagaatggaa aaaatctcac aatataaagc 35760
acgtaggtct tatcacgtgc aaggcatttg gtctatacaa atccattaat gtggaatatc 35820
gattcttggt aattaataga ttaggtgcag atctagatgc ggtgatcaga gccaataata 35880
atagattacc aaaaaggtcg gtgatgttga tcggaatcga aatcttaaat accatacaat 35940
ttatgcacga gcaaggatat tctcacggag atattaaagc gagtaatata gtcttggatc 36000
aaatagataa gaataaatta tatctagtgg attacggatt ggtttctaaa ttcatgtcta 36060
atggagaaca tgttccattt ataagaaatc caaataaaat ggataacggt actctagaat 36120
ttacacctat agattcgcat aaaggatacg ttgtatctag acgtggagat ctagaaacac 36180
ttggatattg tatgattaga tggttgggag gtatcttgcc atggactaag atatctgaaa 36240
caaagaattg tgcattagta agtgccacaa aacagaaata tgttaacaat actgcgactt 36300
tgttaatgac cagtttgcaa tatgcaccta gagaattgct gcaatatatt accatggtaa 36360
actctttgac atattttgag gaacccaatt atgacgagtt tcggcacata ttaatgcagg 36420
gtgtatatta ttaagtgtgg tgtttggtcg atgtaaaatt tttgtcgata aaaattaaaa 36480
aataacttaa tttattattg atctcgtgtg tacaaccgaa atcatggcga tgttttacgc 36540
acacgctctc ggtgggtacg acgagaatct tcatgccttt cctggaatat catcgactgt 36600
tgccaatgat gtcaggaaat attctgttgt gtcagtttat aataacaagt atgacattgt 36660
aaaagacaaa tatatgtggt gttacagtca ggtgaacaag agatatattg gagcactgct 36720
gcctatgttt gagtgcaatg aatatctaca aattggagat ccgatccatg atcaagaagg 36780
aaatcaaatc tctatcatca catatcgcca caaaaactac tatgctctaa gcggaatcgg 36840
gtacgagagt ctagacttgt gtttggaagg agtagggatt catcatcacg tacttgaaac 36900
aggaaacgct gtatatggaa aagttcaaca tgattattct actatcaaag agaaggccaa 36960
agaaatgaat gcacttagtc caggacctat cattgattac cacgtctgga taggagattg 37020
tatctgtcaa gttactgctg tggacgtaca tggaaaggaa attatgagaa tgagattcaa 37080
aaagggtgcg gtgcttccga tcccaaatct ggtaaaagtt aaacttgggg agaatgatac 37140
agaaaatctt tcttctacta tatcggcggc accatcgagg taaccacctc tctggaagac 37200
agcgtgaata atgtactcat gaaacgtttg gaaactatac gccatatgtg gtctgtcgta 37260
tatgatcatt ttgatattgt gaatggtaaa gaatgctgtt atgtgcatac gcatttgtct 37320
aatcaaaatc ttataccgag tactgtaaaa acaaatttgt acatgaagac tatgggatca 37380
tgcattcaaa tggattccat ggaagctcta gagtatctta gcgaactgaa ggaatcaggt 37440
ggatggagtc ccagaccaga aatgcaggaa tttgaatatc cagatggagt ggaagacact 37500
gaatcaattg agagattggt agaggagttc ttcaatagat cagaacttca ggctggtgaa 37560
tcagtcaaat ttggtaattc tattaatgtt aaacatacat ctgtttcagc taagcaacta 37620
agaacacgta tacggcagca gcttccttta tactctcatc ttttaccaac acaaagggtg 37680
gatatttgtt cattggagtt gataataata cacacaaagt aattggattc acggtgggtc 37740
atgactacct cagactggta gagaatgata tagaaaagca tatcaaaaga cttcgtgttg 37800
tgcatttctg tgagaagaaa gaggacatca agtacacgtg tcgattcatc aaggtatata 37860
aacctgggga tgaggctacc tcgacatacg tgtgcgctat caaagtggaa agatgctgtt 37920
gtgctgtgtt tgcagattgg ccagaatcat ggtatatgga tactaatggt atcaagaagt 37980
attctccaga tgaatgggtg tcacatataa aattttaatt aatgtaatag agaacaaata 38040
ataaggttgt aatatcatat agacaataac taacaattaa ttagtaactg ttatctcttt 38100
tttaactaac caactaacta tatacctatt aatacatcgt aattatagtt cttaacatct 38160
attaatcatt aattcgcttc tttaattttt tataaactaa cattgttaat tgaaaaggga 38220
taacatgtta cagaatataa attatatatg gattttttta aaaaggaaat acttgactgg 38280
agtatatatt tatctcttca ttatatagca cgcgtgtttt ccaatttttc cacatcccat 38340
ataatacagg attataatct cgttcgaaca tacgagaaag tggataaaac aatagttgat 38400
tttttatcta ggttgccaaa tttattccat attttagaat atggggaaaa tattctacat 38460
atttattcta tggatgatgc taatacgaat attataattt tttttctaga tagagtatta 38520
aatattaata agaacgggtc atttatacac aatctcaggt tatcatcatc cattaatata 38580
aaagaatatg tatatcaatt agttaataat gatcatccag ataataggat aagactaatg 38640
cttgaaaatg gacgtagaac aagacatttt ttgtcctata tatcagatac agttaatatc 38700
tatatatgta ttttaataaa tcatggattt tatatagatg ccgaagacag ttacggttgt 38760
acattattac atagatgtat atatcactat aagaaatcag aatcagaatc atacaatgaa 38820
ttaattaaga tattgttaaa taatggatca gatgtagata aaaaagatac gtacggaaac 38880
acacctttta tcctattatg taaacacgat atcaacaacg tggaattgtt tgagatatgt 38940
ttagagaatg ctaatataga ctctgtagac tttaatagat atacacctct tcattatgtc 39000
tcatgtcgta ataaatatga ttttgtaaag ttattaattt ctaaaggagc aaatgttaat 39060
gcgcgtaata gattcggaac tactccattt tattgtggaa ttatacacgg tatctcgctt 39120
ataaaactat atttggaatc agacacagag ttagaaatag ataatgaaca tatagttcgt 39180
catttaataa tttttgatgc tgttgaatct ttagattatc tattatccag aggagttatt 39240
gatattaact atcgtactat atacaacgaa acatctattt acgacgctgt cagttataat 39300
gcgtataata cgttggtcta tctattaaac agaaatggtg attttgagac gattactact 39360
agtggatgta catgtatttc ggaagcagtc gcaaacaaca acaaaataat aatggaagta 39420
ctattgtcta aacgaccatc tttgaaaatt atgatacagt ctatgatagc aattactaaa 39480
cataaacagc ataatgcaga tttattgaaa atgtgtataa aatatactgc gtgtatgacc 39540
gattatgata ctcttataga tgtacagtcg ctacagcaat ataaatggta tattttaaaa 39600
tgtttcgatg aaatagatat catgaagaga tgttatataa aaaataaaac tgtattccaa 39660
ttagtttttt gtatcaaaga cattaatact ttaatgagat acggtaaaca tccttctttc 39720
gtgaaatgca ctagtctcga cgtatacgga agtcgtgtac gtaatatcat agcatctatt 39780
agatatcgtc agagattaat tagtctatta tccaagaagc tggatcctgg agataaatgg 39840
tcgtgttttc ctaacgaaat aaaatataaa atattggaaa actttaacga taacgaacta 39900
tccacatatc taaaaatctt ataaacacta ttaaaatata aaatctaagt aggataaaat 39960
cacactacat cattgtttcc ttttagtgct cgacagtgta tactattttt aacactcata 40020
aataaaaatg aaaacgattt ccgttgttac gttgttatgc gtactacctg ctgttgttta 40080
ttcaacatgt actgtaccca ctatgaataa cgctaaatta acgtctaccg aaacatcgtt 40140
taatgataaa cagaaagtta cgtttacatg tgatcaggga tatcattctt cggatccaaa 40200
tgctgtctgc gaaacagata aatggaaata cgaaaatcca tgcaaaaaaa tgtgcacagt 40260
ttctgattac atctctgaat tatataataa accgctatac gaagtgaatt ccaccatgac 40320
actaagttgc aacggcgaaa caaaatattt tcgttgcgaa gaaaaaaatg gaaatacttc 40380
ttggaatgat actgttacgt gtcctaatgc ggaatgtcaa cctcttcaat tagaacacgg 40440
atcgtgtcaa ccagttaaag aaaaatactc atttggggaa tatatgacta tcaactgtga 40500
tgttggatat gaggttattg gtgcttcgta cataagttgt acagctaatt cttggaatgt 40560
tattccatca tgtcaacaaa aatgtgatat gccgtctcta tctaatggat taatttccgg 40620
atctacattt tctatcggtg gcgttataca tcttagttgt aaaagtggtt ttacactaac 40680
ggggtctcca tcatccacat gtatcgacgg taaatggaat cccgtactcc caatatgtgt 40740
acgaactaac gaagaatttg atccagtgga tgatggtccc gacgatgaga cagatttgag 40800
caaactctcg aaagacgttg tacaatatga acaagaaata gaatcgttag aagcaactta 40860
tcatataatc atagtggcgt taacaattat gggcgtcata tttttaatct ccgttatagt 40920
attagtttgt tcctgtgaca aaaataatga ccaatataag ttccataaat tgctaccgta 40980
aatataaatc cgttaaaata atgaataatt aataacgaac aagtatcaaa agattaaaga 41040
attatagcta gaatcaattg agatgtcttc ttcagtggat gttgatatct acgatgccgt 41100
tagagcattt ttactcaggc actattataa caagagattt attgtgtatg gaagaagtaa 41160
cgccatatta cataatatat acaggctatt tacaagatgc gccgttatac cgttcgatga 41220
tatagtacgt actatgccaa atgaatcacg tgttaaacaa tgggtgatgg atacacttaa 41280
tggtataatg atgaatgaac gcgatgtttc tgtaagcgtt ggcaccggaa tactattcat 41340
ggaaatgttt ttcgattaca ataaaaatag tatcaacaat caactaatgt atgatataat 41400
taatagcgta tctataattc tagctaatga gagatataga agcgctttta acgacgatgg 41460
tatatacatc cgtagaaata tgattaacaa gttgtacgga tacgcatctc taactactat 41520
tggcacgatc gctggaggtg tttgttatta tctgttgatg catctagtta gtttgtataa 41580
ataattattt caatatacta gttaaaattt taagatttta aatgtataaa aaactaataa 41640
cgtttttatt tgtaataggt gcattagcat cctattcgaa taatgagtac actccgttta 41700
ataaactgag tgtaaaactc tatatagatg gagtagataa tatagaaaat tcatatactg 41760
atgataataa tgaattggtg ttaaatttta aagagtacac aatttctatt attacagagt 41820
catgcgacgt cggatttgat tccatagata tagatgttat aaacgactat aaaattattg 41880
atatgtatac cattgactcg tctactattc aacgcagagg tcacacgtgt agaatatcta 41940
ccaaattatc atgccattat gataagtacc cttatattca caaatatgat ggtgatgagc 42000
gacaatattc tattactgca gagggaaaat gctataaagg aataaaatat gaaataagta 42060
tgatcaacga tgatactcta ttgagaaaac atactcttaa aattggatct acttatatat 42120
ttgatcgtca tggacatagt aatacatatt attcaaaata tgatttttaa aaatttaaaa 42180
tatattatca cttcagtgac agtagtcaaa taacaaacaa caccatgaga tatattataa 42240
ttctcgcagt tttgttcatt aatagtatac acgctaaaat aactagttat aagtttgaat 42300
ccgtcaattt tgattccaaa attgaatgga ctggggatgg tctatacaat atatccctta 42360
aaaattatgg catcaagacg tggcaaacaa tgtatacaaa tgtaccagaa ggaacatacg 42420
acatatccgc atttccaaag aatgatttcg tatctttctg ggttaaattt gaacaaggcg 42480
attataaagt ggaagagtat tgtacgggac tatgcgtcga agtaaaaatt ggaccaccga 42540
ctgtaacatt gactgaatac gacgaccata tcaatttgta catcgagcat ccgtatgcta 42600
ctagaggtag caaaaagatt cctatttaca aacgcggtga catgtgtgat atctacttgt 42660
tgtatacggc taacttcaca ttcggagatt ctaaagaacc agtaccatat gatatcgatg 42720
actacgattg cacgtctaca ggttgcagca tagactttgt cacaacagaa aaagtgtgcg 42780
tgacagcaca gggagccaca gaagggtttc tcgaaaaaat tactccatgg agttcgaaag 42840
tatgtctgac acctaaaaag agtgtatata catgcgcaat tagatccaaa gaagatgttc 42900
ccaatttcaa ggacaaaatg gccagagtta tcaagagaaa atttaataaa cagtctcaat 42960
cttatttaac taaatttctc ggtagcacat caaatgatgt taccactttt cttagcatgc 43020
ttaacttgac taaatattca taactaattt ttattaatga tacaaaaacg aaataaaact 43080
gcatattata cactggttaa cgcccttata ggctctaacc attttcaaga tgaggtccct 43140
gattatagtc cttctgttcc cctctatcat ctactccatg tctattagac aatgtgagaa 43200
gactgaagag gaaacatggg gattgaaaat agggttgtgt ataattgcca aagatttcta 43260
tcccgaaaga actgattgca gtgttcatct cccaactgca agtgaaggat tgataactga 43320
aggcaatgga ttcagggata tacgaaacac cgataaatta taaaaaaagc aatgtgtccg 43380
ctgtttccgt taataatact attttcgtaa ctggcggatt attcataaat aactctaata 43440
gcacgatcgt ggttaacaat atggaaaaac ttgacattta taaagacaaa caatggtcga 43500
ttatagaaat gcctatggct agggtatatc acggcatcga ctcgacattt ggaatgttat 43560
attttgccgg aggtctatcc gttaccgaac aatatggtaa tttagagaaa aacaacgaga 43620
tatcttgtta caatcctaga acgaataagt ggtttgatat ttcatatact atttataaga 43680
tatccatatc atcattgtgt aaactaaata acgtcttcta tgtatttagt aaggacattg 43740
gatatgtgga aaagtatgat ggtgcatgga agttagtaca tgatcgtctc cccgctataa 43800
aggcattatc aacttctcct tattgattga aaatgaaaat ataaatagtt tttatgtata 43860
gcagtattac cctatagttt tattgcttac tactaacatg gatacagatg ttacaaatgt 43920
agaagatatc ataaatgaaa tagatagaga gaaagaagaa atactaaaaa atgtagaaat 43980
tgaaaataat aaaaacatta acaagaatca tccaagtgga tatattagag aagcactcgt 44040
tattaatacc agtagtaata gtgattccat tgataaagaa gttatagaat gtatctgtca 44100
cgatgtagga atatagatca tatctactaa tttttataat cgatacaaaa cataaaaaac 44160
aactcgttat tacatagcag gcatggaatc cttcaagtat tgttttgata acgatggcaa 44220
gaaatggatt atcggaaata ctttatattc tggtaattca atactatata aggtcagaaa 44280
aaatttcact agttcgttct acaattacgt aatgaagata gatcacaaat cacacaagcc 44340
attgttgtct gaaatacgat tctatatatc tgtattggat cctttgacta tcgacaactg 44400
gacacgggaa cgtggtataa agtatttggc tattccagat ctgtatggaa ttggagaaac 44460
cgatgattat atgttcttcg ttataaagaa tttgggaaga gtattcgccc caaaggatac 44520
tgaatcagtc ttcgaagcat gcgtcactat gataaacacg ttagagttta tacactctca 44580
aggatttacc catggaaaaa tagaaccgag gaatatactg attagaaata aacgtctttc 44640
actaattgac tattctagaa ctaacaaact atacaagagt ggaaactcac atatagatta 44700
caacgaggac atgataactt caggaaatat caattatatg tgtgtagaca atcatcttgg 44760
agcaacagtt tcaagacgag gagatttaga aatgttggga tattgcatga tagaatggtt 44820
cggtggcaaa cttccatgga aaaacgaaag tagtataaaa gtaataaaac aaaaaaaaga 44880
atataaaaaa tttatagcta ctttctttga ggactgtttt cctgaaggaa atgaacctct 44940
ggaattagtt agatatatag aattagtata cacgttagat tattctcaaa ctcctaatta 45000
tgacagacta cgtaaactgt ttatacaaga ttgaaattat attctttttt ttatagagtg 45060
tggtagtgtt acggatattt aatattagac tatctctatc gcgctacacg accaatatcg 45120
attactatgg atatcttcag ggaaatcgca tcttctatga aaggagagaa tgtattcatt 45180
tctccagcgt caatctcgtc agtattgaca atactgtatt atggagctaa tggatccact 45240
gctgaacagc tatcaaaata tgtagaaaag gaggagaaca tggataaggt tagcgctcaa 45300
aatatctcat tcaaatccat aaataaagta tatgggcgat attctgccgt gtttaaagat 45360
tcctttttga gaaaaattgg cgataagttt caaactgttg acttcactga ttgtcgcact 45420
atagatgcaa tcaacaagtg tgtagatatc tttactgagg ggaaaatcaa tccactattg 45480
gatgaaccat tgtctcctga tacctgtctc ctagcaatta gtgccgtata ctttaaagca 45540
aaatggttga cgccattcga aaaggaattt accagtgatt atccctttta cgtatctccg 45600
acggaaatgg tagatgtaag tatgatgtct atgtacggca aggcatttaa tcacgcatct 45660
gtaaaggaat cattcggcaa cttttcaatc atagaactgc catatgttgg agatactagt 45720
atgatggtca ttcttccaga caagattgat ggattagaat ccatagaaca aaatctaaca 45780
gatacaaatt ttaagaaatg gtgtaactct ctggaagcta cgtttatcga tgttcacatt 45840
cccaagttta aggtaacagg ctcgtataat ctggtggata ctctagtaaa gtcaggactg 45900
acagaggtgt tcggttcaac tggagattat agcaatatgt gtaattcaga tgtgagtgtc 45960
gacgctatga tccacaaaac gtatatagat gtcaatgaag agtatacaga agcagctgca 46020
gcaacttgtg cactggtgtc agactgtgca tcaacaatta caaatgagtt ctgtgtagat 46080
catccgttca tctatgtgat taggcatgtt gatggaaaaa ttcttttcgt tggtagatat 46140
tgctctccga caactaattg ttaaccattt tttttaaaaa atagaaaaaa catgtggtat 46200
tagtgcaggt cgttattctt ccaattgcaa ttggtaagat gacggccaac tttagtaccc 46260
acgtcttttc accacagcac tgtggatgtg acagactgac cagtattgat gacgtcagac 46320
aatgtttgac tgaatatatt tattggtcgt cctatgcata ccgcaacagg caatgcgctg 46380
gacaattgta ttccacactc ctctctttta gagatgatgc ggaattagtg ttcatcgaca 46440
ttcgcgagct ggtaaaaaat atgccgtggg atgatgtcaa agattgtgca gaaatcatcc 46500
gttgttatat accggatgag caaaaaacca tcagagagat ttcggccatc atcggacttt 46560
gtgcatatgc tgctacttac tggggaggtg aagaccatcc cactagtaac agtctgaacg 46620
cattgtttgt gatgcttgag atgctcaatt acgtggatta taacatcata ttccggcgta 46680
tgaattgatg agttgtacat cttgacattt tcttctttct tctcttctcc ctttcccaga 46740
aacaaacttt ttttacccac tataaaataa aatgagtata ctacctgtta tatttctttc 46800
tatatttttt tattcttcat tcgttcagac ttttaacgcg cctgaatgta tcgacaaagg 46860
gcaatatttt gcatcattca tggagttaga aaacgagcca gtaatcttac catgtcctca 46920
aataaatacg ctatcatccg gatataatat attagatatt ttatgggaaa aacgaggagc 46980
ggataatgat agaattatac cgatagataa tggtagcaat atgctaattc tgaacccgac 47040
acaatcagac tctggtattt atatatgcat taccacgaac gaaacctact gtgacatgat 47100
gtcgttaaat ttgacaatcg tgtctgtctc agaatcaaat atagatctta tctcgtatcc 47160
acaaatagta aatgagagat ctactggcga aatggtatgt cccaatatta atgcatttat 47220
tgctagtaac gtaaacgcag atattatatg gagcgggcat cgacgcctta gaaataagag 47280
acttaaacaa cggacacctg gaattattac catagaagat gttagaaaaa atgatgctgg 47340
ttattataca tgtgttttag aatatatata cggtggcaaa acatataacg taaccagaat 47400
tgtaaaatta gaggtacggg ataaaataat accttctact atgcaattac cagatggcat 47460
tgtaacttca ataggtagta atttgactat tgcatgcaga gtatcgttga gacctcccac 47520
aacggatgca gacgtctttt ggataagtaa tggtatgtat tacgaagaag atgatgggga 47580
cggaaacggt agaataagtg tagcaaataa aatctatatg accgataaga gacgtgttat 47640
tacatcccgg ttaaacatta atcctgtcaa ggaagaagat gctacaacgt ttacgtgtat 47700
ggcgtttact attcctagca tcagtaaaac agttactgtt agtataacgt gaatgtatgt 47760
tgttacattt ccatgtcaat tgagtttata agaattttta tacattatct tccaacaagc 47820
aattgacgaa cgtattgcta tgattaactc ccacgatact atgcatatta ttaatcatta 47880
acttgcagac tatacctaga gctattttga catactcgtg ttcttgtgta attgcagtat 47940
ctatattatt aaagtacgta aatctagcta tagttttatt atttaatttt agataatata 48000
ccgtctcctt atttttaaaa attgccacat cctttattaa atcatgaatg ggaatttcta 48060
tgtcatagtt aatatattgt gaacaacaag agcagatatc tataggaaag ggtggaatgc 48120
gatacattga tctatgtagt tttaaaacac acgcaaactt tgaagaattt atataaatca 48180
ttccatcgat acatccttct atgttgagat gtatatatcc aggaattcgt ttattaatat 48240
cgggaaatgt ataaactaaa acattgcccg gaagcggagc ttctaccgga gttatatcag 48300
tttttaactt acaaaatgta accaatacct ttgcatgact tgttttgttc ggcaacgtta 48360
gtttaaactt gacgaatgga ttaattacaa tagcatgatc cgcgcatcta ttaagttttt 48420
ttactttaac gcccttgtat gtttttacag agactttatc taaatttcta gtgcttgtat 48480
gtgttataaa tataacggga tatagaactg aatcacctac cttagatacc caattacatt 48540
ttatcagatc cagataataa acaaattttg tcgccctaac taattctata ttgttatata 48600
ttttacaatt ggttatgata tcatgtaata acttggaatc taacgcacat cgtcgtacgt 48660
ttatacaatt gtgatttagt gtagtatatc tacacatgta tttttccgcg ctatagtatt 48720
ctggactagt gataaaacta tcgttatatc tgtcttcaat gaactcatcg agatattgct 48780
ctctgtcata ttcatacacc tgcataaact ttctagacat cttacaatcc gtgttatttt 48840
aggatcatat ttacatattt acgggtatat caaagatgtt agattagtta atgggaatcg 48900
tctataataa tgaatattaa acaattatat gaggactttt accacaaagc atcataaaaa 48960
tgagtcgtcg tctgatttat gttttaaata tcaaccgcga atcaactcat aaaatacaag 49020
agaatgaaat atatacatat tttagtcatt gcaatataga ccatacttct acagaacttg 49080
attttgtagt taaaaactat gatctaaaca gacgacaacc tgtaactggg tatactgcac 49140
tacactgcta tttgtataat aattacttta caaacgatgt actgaagata ttattaaatc 49200
atggagtgga tgtaacgatg aaaaccagta gcggacgtat gcctgtttat atattgctta 49260
ctagatgttg caatatttca catgatgtag tgatagatat gatagacaaa gataaaaacc 49320
acttattaca tagagactat tccaacctat tactagagta tataaaatct cgttacatgt 49380
tattaaagga agaggatatc gatgagaaca tagtatccac tttattagat aagggaatcg 49440
atcctaactt taaacaagac ggatatacag cgttacatta ttattatttg tgtctcgcac 49500
acgtttataa accaggtgag tgtagaaaac cgataacgat aaaaaaggcc aagcgaatta 49560
tttctttgtt tatacaacat ggagctaatc taaacgcgtt agataattgt ggtaatacac 49620
cattccattt gtatcttagt attgaaatgt gtaataatat tcatatgact aaaatgctgt 49680
tgacttttaa tccgaatttc gaaatatgta ataatcatgg attaacgcct atactatgtt 49740
atataacttc cgactacata caacacgata ttcttgttat gttaatacat cactatgaaa 49800
caaatgttgg agaaatgccg atagatgagc gtcgtataat cgtattcgag tttatcaaaa 49860
catattctac acgtcctgca gattcgataa cttatttgat gaataggttt aaaaatatag 49920
atatttatac ccgctatgaa ggaaagacat tattacacgt agcatgtgaa tataataata 49980
cacacgtaat agattatctt atacgtatca acggagatat aaatgcgtta accgacaata 50040
acaaacacgc tacacaactc attatagata acaaagaaaa ttccccatat accattaatt 50100
gtttactgta tatacttaga tatattgtag ataagaatgt gataagatcg ttggtggatc 50160
aacttccatc tctacctatc ttcgatataa aatcatttga gaaattcata tcctactgta 50220
tacttttaga tgacacattt tacaatagac acgttaggaa tcgcgattct aaaacgtatc 50280
gatacgcatt ttcaaaatac atgtcgtttg ataaatacga tggtataata actaaatgtc 50340
ataaagaaac aatattgctc aaactatcca ctgttctaga cactacacta tatgcagttt 50400
taagatgcca taattcgaaa aagttaagaa gatacctcac cgagttaaaa aaatataata 50460
acgataagtc ctttaaaata tattctaata ttatgaatga gagatacctt aatgtatatt 50520
ataaagatat gtacgtgtca aaggtatatg ataaactatt tcctgttttc acagataaaa 50580
attgtctact aacattacta ccttcagaaa ttatatacga aatattatac atgctgacaa 50640
ttaacgatct ttataatata tcgtatccac ctaccaaagt atagttgtat ttttctcatg 50700
cgatgtgtgt aaaaaaactg atattatata aatattttag tgccgtataa taaagatgac 50760
gatgaaaatg atggtacata tatatttcgt atcattattg ttattgctat tccacagtta 50820
cgccatagac atcgaaaatg aaatcacaga attcttcaat aaaatgagag atactctacc 50880
agctaaagac tctaaatggt tgaatccagc atgtatgttc ggaggcacaa tgaatgatat 50940
agccgctcta ggagagccat tcagcgcaaa gtgtcctcct attgaagaca gtcttttatc 51000
gcacagatat aaagactatg tggttaaatg ggaaaggcta gaaaaaaata gacggcgaca 51060
ggtttctaat aaacgtgtta aacatggtga tttatggata gccaactata catctaaatt 51120
cagtaaccgt aggtatttgt gcaccgtaac tacaaagaat ggtgactgtg ttcagggtat 51180
agttagatct catattagaa aacctccttc atgcattcca aaaacatatg aactaggtac 51240
tcatgataag tatggcatag acttatactg tggaattctt tacgcaaaac attataataa 51300
tataacttgg tataaagata ataaggaaat taatatcgac gacattaagt attcacaaac 51360
gggaaaggaa ttaattattc ataatccaga gttagaagat agcggaagat acgactgtta 51420
cgttcattac gacgacgtta gaatcaagaa tgatatcgta gtatcaagat gtaaaatact 51480
tacggttata ccgtcacaag accacaggtt taaactaata ctagatccaa aaatcaacgt 51540
aacgatagga gaacctgcca atataacatg cactgctgtg tcaacgtcat tattgattga 51600
cgatgtactg attgaatggg aaaatccatc cggatggctt ataggattcg attttgatgt 51660
atactctgtt ttaactagta gaggcggtat taccgaggcg accttgtact ttgaaaatgt 51720
tactgaagaa tatataggta atacatataa atgtcgtgga cacaactatt attttgaaaa 51780
aacccttaca actacagtag tattggagta aatatacaat gcatttttat atacattact 51840
gaataattat tattattatt tatatcgtat ttgtgctata acgcgactat ctaggtattt 51900
gtatctcacc gatagagaac atataaatgt agactctatt aaacagttgt gtaaaatatc 51960
agatcctaat gcatgttata gatgtggatg tacggcttta catgagtact tttataatta 52020
tagatcagtc aacggaaaat acaagtatag atacaacggt tactatcaat attatttatc 52080
tagcgattat gaaaattata atgaatatta ttatgatgat tatgatagaa ctggtatgaa 52140
cagtgagagt gataatatat caatcaaaac agaatatgaa ttctatgatg aaacacaaga 52200
tcaaagtaca caactagtag gttacgacat taaactcaaa accaatgagg atgattttat 52260
ggctatgata gatcagtggg tgtccatgat tatatagatg aatcaattaa taaagtagta 52320
tatggaagag agtctcacgt aagatggcgg gatatatggc aagaacataa tgatggcgta 52380
tacagtatag gaaaggagtg catagataat atatacgaag acaaccatac cgtagacgaa 52440
ttctacaaga tagacagcgt atcagatgta gatgacgcgg aacacatatc tccgataact 52500
aatgatgtat ctacacaaac atgggaaaag aaatcagagt tagatagata catggaaatg 52560
tatcctcgtc atagatatag taagcattct gtctttaagg gattttctga caaagttaga 52620
aaaaatgatt tagacatgaa tgtggtaaaa gaattacttt ctaacggtgc atctctaaca 52680
attaaggata gcagtaataa ggatccaata accgtttatt ttcgaagaac gataatgaat 52740
ttagaaatga ttgatgaacg aaagtatata gtacactcct atctaaaaaa ttataaaaat 52800
ttcgattatc catttttcag gaagttagtt ttgactaata aacattgtct caacaattat 52860
tataatataa gcgacagcaa atatggaaca ccgctacata tattggcgtc taataaaaaa 52920
ttaataactc ctaattacat gaagttatta gtgtataacg gaaatgatat aaacgcacga 52980
ggtgaagata cacaaatgcg aactccatta cacaaatatt tgtgtaaatt tgtatatcat 53040
aatattgaat atggtatccg atactataat gaaaagatta tagacgcatt tatagagtta 53100
ggagccgatc taactattcc aaatgacgat ggaatgatac cagtagttta ctgtatacac 53160
tcaaatgccg aatatggtta taacaatatt actaacataa agataatacg taaactactt 53220
aatcttagta gacgtgcgtc acataatcta tttagagatc gagtcatgca cgattatata 53280
agtaatacat atattgatct tgagtgttta gatattatta gatcgttgga tggattcgat 53340
atcaatggtt actttgaagg acgtacacca cttcattgcg ctatacaaca taacttcact 53400
cagattgcta agtacttatt agatcgagga gctgatatag tcgtacccaa cacattgatt 53460
atacatcagt acatacagta aatagcatag atatggagga ggatacaaat atttcaaata 53520
aagttataag gtacaacact gtcaataata tatgggaaac attacctaac ttctggactg 53580
gaactataaa tccaggcgtg gtctcgcata aagatgatat atatgttgta tgcgacatca 53640
aagatgaaaa aaatgttaaa acttgtatat ttagatataa cacgaatacg tataacggat 53700
gggaattggt cacgacgaca gaaagcagat tatcagctct gcatactatt ctttataaca 53760
ataccataat gatgttacat tgttatgaat cgtatatgtt acaagataca tttaatgtgt 53820
acactcgcga atggaatcat atgtgtcatc aacattcgaa tagttatatc atgtacaata 53880
tactacccat ctactaaata taatagaata aaataaatga gtatgatcat tttagataac 53940
gattgatttt atcattaccg cttcattctt atattctttg cttacggaac ctatatttag 54000
aaacatctac taacgatttt ttatgcttgc attattaatg gtatgtaata tgattgattg 54060
tgtacgcaat accaatttgt taagtatgaa tacggggtac aaacataaac tgaagtttaa 54120
cattatttat ttatgatata tatcgttatt gtttggtcta taccatggat atctttaaag 54180
aactaatctt aaaacacacg gatgaaaatg ttttgatttc tccagtttct attttatcta 54240
ctttatctat tctaaatcat ggagcagctg gttctacagc tgaacaacta tcaaaatata 54300
tagagaatat gaatgagaat acacccgatg acaataatga catggacgta gatattccgt 54360
attgtgcgac actagctacc gcaaataaaa tatacggtag cgatagtatc gagttccacg 54420
cctccttcct acaaaaaata aaagacgatt ttcaaactgt aaactttaat aatgctaacc 54480
aaacaaagga actaatcaac gaatgggtta agacaatgac aaatggtaaa attaattcct 54540
tattgactag tccgctatcc attaatactc gtatgacagt tgttagcgcc gtccatttta 54600
aagcaatgtg gaaatatcca ttttctaaac atcttacata tacagacaag ttttatattt 54660
ctaagaatat agttaccagt gttgatatga tggtgagcac tgagaataac ttgcaatatg 54720
tacatattaa tgaattattc ggaggattct ctattatcga tattccatac gagggaaact 54780
ctagtatggt aattatacta ccggacgaca tagaaggtat atataacata gaaaaaaata 54840
taacagatga aaaatttaaa aaatggtgtg gtatgttatc tactaaaagt atagacttgt 54900
atatgccaaa gtttaaagtg gaaatgacag aaccgtataa tctggtaccg attttagaaa 54960
atttaggact tactaatata ttcggatatt atgcagattt tagcaagatg tgtaatgaaa 55020
ctatcactgt agaaaaattt ctacatacga cgtttataga tgttaatgag gagtatacag 55080
aagcatcggc cgttacagga gtatttatga ctaacttttc gatggtatat cgtacgaagg 55140
tctacataaa ccatccattc atgtacatga ttaaagacaa cacaggacgt atacttttta 55200
tagggaaata ctgctatccg caataaatat aaacaaatag acttttatca cgtttatcta 55260
tgtctaaata ttacaaatag taatagtata aactaaagct gataatactt aaaaaaataa 55320
taatatcatt tacaattaat agtataaact aaaaattaaa caaatcgtta ttataagtaa 55380
tatcaaaatg atgatatacg gattaatagc gtgtcttata ttcgtgactt catccatcgc 55440
tagtccactt tatattcccg ttattccacc catttcggaa gataaatcgt tcaatagtgt 55500
agaggtatta gtttccttgt ttagagatga ccaaaaagac tatacggtaa cttctcagtt 55560
caataactac actatcgata ccaaagactg gactatcggc gtactatcca cacctgatgg 55620
tttggatata ccattgacta atataactta ttggtcacgg tttactatag gtcgtgcatt 55680
gttcaaatca gagtctgagg atattttcca aaagaaaatg agtattctag gtgtttctat 55740
agaatgtaag aagtcgtcga cattacttac ttttttgacc gtgcgtaaaa tgactcgagt 55800
atttaataaa tttccagata tggcttatta tcgaggagac tgtttaaaag ccgtttatgt 55860
aacaatgact tataaaaata ctaaaactgg agagactgat tacacgtacc tctctaatgg 55920
ggggttgcct gcatactatc gtaatggggt cgatggttga ttattgatta gtatattcct 55980
tattcttttt attcacacaa aaagaacatt tttataaaca tgaaaccact gtctaaatgt 56040
aattatgatc ttgatttata gatgaagatc agcctttaga ggattttaac cagtatgttt 56100
aatatgaaaa aaataaacat aacatatttt gagattaagc gctattgtgc aagattatat 56160
tagaatcaaa ttaatctttc atacgagaaa aataacgaca tacgtcgtca acaaattaaa 56220
ctttttattt attagttaac tagcttatag aacttgctca ttgttatgtt tctaaaacgg 56280
gtacgacata taggacaatt atccgacgca ccggtttctc ttcgtgtttt atgccatata 56340
ttgatgcatg ttatgcaaaa tatatgagta cacgaatcca ataaaccaaa gtatctatcg 56400
ttttgagtaa acaacttcat agcaaattcc acattctttt tctttactta ctctatacac 56460
gtcctcgtat ttatccagta ttttgatgat atccaactca gaaatggttg ttgtattatt 56520
gggtgtattg ggagtatagg tattattagc tatgtaccaa tttaccaacc ctcttaatat 56580
tgattgaaca atcacatcgg ttatccaatc aataaccaca ttaataacta aattgtagtg 56640
tatatataga ccatatatgt ttctattttt ttgacagtta cgtatagttt cagtaagttt 56700
tgattgttgt attcctgtat ctctagataa gttagtcata tagtcccttc cggcgatacg 56760
ttttttccaa gcccgaaatt gattagccaa atgtgtattt atttttgtga tattgatata 56820
atatgtaatg ttattaatat ttcggataat gcatactgtt agtcttatat catttggttc 56880
atctatgtat tgtaatattg ttacatgatc tatagatgat gtattgattt tggcaggatc 56940
gaattccata tccgcgacta aacagtgaaa aaaatgtaaa tactttttaa attttaaatt 57000
agtaaaactt ttttttattt tttatgattc caaaaatact gaatacaaag tcctaaatta 57060
taaatatgga gatcatacta ccacaactta ttattatgca tactcagccg gtgtaataga 57120
tagatatata taattctatt acaccggcag acaattaccg atcggtattt gtcgttacca 57180
acataccgta taatatgtaa tatacaattc cataacccat tgacagttgt tatacatcaa 57240
aattgcaatt cttttgatta cgatgttata agaatgtagt taattgatgt atgatgttaa 57300
tgtgtcctct ttcctcttat aacatcgtaa tcaaaaactt ttttataata tatacctaat 57360
aatgtgtctt aatagttctc gtgattcgtc aaacaatcat tcttataaaa tataataaag 57420
caacgtaaaa cacataaaaa taagcgtaac taataagaca atggatattt acgacgataa 57480
aggtctacag actattaaac tgtttaataa tgaatttgat tgtataagga atgacatcag 57540
agaattattt aaacatgtaa ctgattccga tagtatacaa cttccgatgg aagacaattc 57600
tgatattata gaaaatatca gaaaaatact atatagacga ttaaaaaatg tagaatgtgt 57660
tgacatcgat agtacaataa cttttatgaa atacgatcca aatgatgata ataagcgtac 57720
gtgttctaat tgggtaccct taactaataa ctatatggaa tattgtctag taatatattt 57780
ggaaacaccg atatgtggag gcaaaataaa attataccac cctacaggaa atataaagtc 57840
ggataaggat attatgtttg caaagactct agactttaaa tcaaagaaag tgttaactgg 57900
acgtaaaaca attgccgttc tagacatatc cgtttcatat aatagatcaa tgactactat 57960
tcactacaac gacgacgttg atatagatat acatactgat aaaaatggaa aagagttatg 58020
ttattgttat ataacaatag atgatcatta cttggttgat gtggaaacta taggagttat 58080
agtcaataga tctggaaaat gtctgttagt aaataaccat ctaggtatag gtatcgttaa 58140
agataaacgt ataagcgata gttttggaga tgtatgtatg gatacaatat ttgacttttc 58200
tgaagcacga gagttatttt cattaactaa tgatgataac aggaatatag catgggacac 58260
tgataaacta gacgatgata cagatatatg gactcccgtc acagaagatg attacaaatt 58320
tctttctaga ctagtattgt atgcaaaatc tcaatcggat actgtattcg actattatgt 58380
tcttactggt gatacggaac cacccactgt attcattttc aaggtaacta gattttactt 58440
taatatgccg aaataaaaaa tttttgtata atatctagag gtagaggtat tgtttagata 58500
aatacaaata acatagatac atcgcatact tagcattttt ataaatatac ataagacata 58560
cactttatac attttttttg taaaaatact cataaaaaaa tttataaaaa ttatggcaca 58620
accatatctt gtataggtag tttagttcgt cgagtgaacc tataaacaga taatagacaa 58680
cacgtaataa taataatgcc tactaataca agcataatac cgggagatgg gatatatgac 58740
gttgtagtgt ttgggttttc tgaacgttga tagtctacta atactacatg ctgacatcta 58800
atgcctgtat aaccatgaga gcatctacaa tacataccgt caatatctct agcgtggata 58860
cagtcaccgt gtaaacaata tccatctccc tctggaccgc ataatctgat agctggaata 58920
tctgttgtag cgtttgtaat ttctggcgat gtcgtttcga tagcgttacc actatcggcg 58980
aatgatctga ttatcatagc agcgaacaac aacatcagat atttcatcga catttttgat 59040
ggattttgtg tttatgctgt ttctcagtgt gtgtttatga caagattggg aattttatat 59100
tattaattca gtaatataaa ctaataatat attgttaatt gtgtaaataa tataaaaata 59160
acaatacaat attgaatgtg ttgctgttaa aaatgatcat aaacacggag tttattttat 59220
atgtctcgca taaacattac taaaaaaata tattgttctg tttttctttc acatctttaa 59280
ttatgaaaaa gtaaatcatt atgagatgga cgagattgta cgcatcgttc gcgacagtat 59340
gtggtacata cctaacgtat ttatggacga cggtaagaat gaaggtcacg tttctgtcaa 59400
caatgtctgt catatgtatt tcacgttctt tgatgtggat acatcgtctc atctgtttaa 59460
gctagttatt aaacactgcg atctgaataa acgaggtaac tctccattac attgctatac 59520
gatgaataca cgatttaatc catctgtatt aaagatattg ttacaccacg gcatgcgtaa 59580
ctttgatagc aaggatgaaa aaggacacca ctatcaatcg ataacaagat ctttgatata 59640
ctaacggaca ccattgatga ctttagtaaa tcatccgatc tattgctgtg ttatcttaga 59700
tataaattca atgggagctt aaactattac gttctgtaca aaggatccga cgaggatgaa 59760
ctcacttctc ttcattacta ctgtaaacac atatccacgt tctacaaaag caattattac 59820
aagttaagtc acactaagat gcgagccgag aagcgattca tctacgcgat aatagattat 59880
ggagcaaaca ttaacgcggt tacacactta ccttcaacag tataccaaac atagtcctcg 59940
tgtggtgtat gctcttttat ctcgaggagc cgatacgagg atacgtaata atcttgattg 60000
tacacccatc atggaacgat tgtgcaacag gtcatattct cataatgtta ctcaattggc 60060
acgaacaaaa ggaagaagga caacatctac tttatctatt cataaaacat aatcaaggat 60120
acactctcaa tatactacgg tatctactag ataggttcga cattcagaaa gacgaatact 60180
ataataccgc ctttcaaaat tgtaacaaca atgttgcctc atacatcgga tacgacatca 60240
accttccgac taaagacggt attcgacttg gtgtttgaaa acagaaacat catatacaag 60300
gcggatgttg tgaatgacat catccaccac agactgaaag tatctctacc tatgattaaa 60360
tcgttgttct acaagatgtc tctccctacg acgattacta cgtaaagaag ataatagcct 60420
actgcctatt aagggacgag tcattcgcgg aactacatag taaattctgt ttaaacgagg 60480
actataaaag tgtatttatg aaaaatatat cattcgataa gatagattcc atcatcgtga 60540
cataagtcgc cttaaagaga ttcgaatctc cgacaccgac ctgtatacgg tatcacagct 60600
atcttaaagc catacattca gacagtcaca tttcatttcc catgtacgac gatctcatag 60660
aacagtgcca tctatcgatg gagcgtaaaa gtaaactcgt cgacaaagca ctcaataaat 60720
tagagtctac catcggtcaa tctagactat cgtatttgcc tccggaaatt atgcgcaata 60780
tcatctaaac agtatgttgt acgaaaagaa ccattacaaa tattatccat gatagaaaga 60840
aaatatctat atgattggag aagtaggaaa caggaacaag acgacgatta ctacattatt 60900
aaatcatgaa gtccgtatta tactcgtata tattgtttct ctcatgtata ataataaacg 60960
gaagagatat agcaccgcat gcaccatccg atggaaagtg taaagacaac gaatacaaac 61020
gccataattt gtgtccggga acatacgctt ccagattatg cgatagcaag actaacacac 61080
aatgtacgcc gtgtggttcg ggtaccttca catctcgcaa taatcattta cccgcttgtc 61140
taagttgtaa cggaagacgc gaccgtgtaa cacgactcac aatagaatct gtgaatgctc 61200
tcccggatat tattgtcttc tcaaaggatc atccggatgc aaggcatgtg tttcccaaac 61260
aaaatgtgga ataggatacg gagtatccgg agacgtcatc tgttctccgt gtggtctcgg 61320
aacatattct cacaccgtct cttccgcaga taaatgcgaa cccgtaccca gtaatacctt 61380
taactatatc gatgtggaaa ttaatctgta tccagttaac gaccactacc ggtctcagcg 61440
aatccatctc aacgtcggaa ctaactatta ctatgaatca taaagactgt aatcccgtat 61500
ttcgtgagga atacttctcc gtccttaata aggtagcaac ttcaggtttc tttacaggag 61560
aaaggtgtgc actctgaatt tcgagattaa atgcaataac aaaaattttt cctccaaaca 61620
gttaacgaaa gcaaagaatg atgacggtat catgccgcat tcggagactg tctatctagc 61680
gtcgacatct atatactata tagtaatacc aatactcaag actacgaaac tgatacaatc 61740
tcttatcatg tgggtaatgt tctcgatgtc gatagccata tgcccggtag ttgcgatata 61800
cataaactga tcactaattc caaacccacc cgctttttat agtaagtttt tcacccataa 61860
ataataaata caataattaa tttctcgtaa aagtagaaaa tatattctaa tttattgcac 61920
ggtaaggaag tagaatcata aagaacagta ctcaatcaat agcaatcatg aaacaatata 61980
tcgtcctggc atgcatgtgc ctgccagtct tcagcaatca tcctcatcct cctcctcgtg 62040
tacggaagaa gaaaacaaac atcatatggg aatcgatgtt attatcaaag tcacaaagca 62100
agaccaaaca ccgaccaatg ataagatttg ccaatccgta acggaaatta cagagtccga 62160
gtcagatcca gatcccgagg tggaatcaga agatgattcc acatcagtcg aggatgtaga 62220
tcctcctacc acttattact ccatcatcgg tggaggtctg agaatgaact ttggattcac 62280
caaatgtcct cagattaaat ccatctcaga atccgctgat ggaaacacag tgaatgctag 62340
attgtccagc gtgtccccag gacaaggtaa ggactctccc gcgatcactc atgaagaagc 62400
tctggctatg atcaaagact gtgaggtgtc tatcgacatc agatgtagcg aagaagagaa 62460
agacagcgac atcaagaccc atccagtact cgggtctaac atctctcata agaaagtgag 62520
ttacgaagat atcatcggtt caacgatcgt cgatacaaaa tgtgtcaaga atctagagtt 62580
tagcgttcgt atcggagaca tgtgcaagga atcatctgaa cttgaggtca aggatggatt 62640
taagtatgtc gacggatcgg catctgaagg tgcaaccgat gatacttcac tcatcgattc 62700
aacaaaactc aaagcgtgtg tctgaatcga taactctatt catctgaaat tggatgagta 62760
gggttaatcg aacgattcag gcacaccacg aattaaaaaa gtgtaccgga cactatattc 62820
cggtttgcaa aacaaaaatg ttcttaacta cattcacaaa aagttacctc tcgcgacttc 62880
ttctttttct gtctcaatag tgtgatacga ttatgacact attcctattc ctattcctat 62940
ttcctttcag ggtatcacaa aaatattaaa cctctttctg atggtctcat aaaaaaagtt 63000
ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 63060
aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 63120
ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 63180
tctctttctc tctttgatgg tctcataaaa aaagttttac aaaaatattt ttattctctt 63240
tctctctttg atggtctcat aaaaaaagtt ttacaaaaat atttttattc tctttctctc 63300
tttgatggtc tcataaaaaa agttttacaa aaatattttt attctctttc tctctttgat 63360
ggtctcataa aaaaagtttt acaaaaatat ttttattctc tttctctctt tgatggtctc 63420
ataaaaaata ttaaacctct ttctgatggt gtcactaaaa tatttttatt ctcattctca 63480
ttttctcttt ctctcttcaa tggagtcata aaatattttt attctctttc tctcttcgat 63540
ggtctcacaa aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctcat 63600
tctcattttc tctttctctc ttcaatggag tcataaaata tttttattct ctttctctct 63660
tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 63720
ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 63780
agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga 63840
gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct 63900
ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata 63960
ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct 64020
cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 64080
tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 64140
ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 64200
agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga 64260
gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct 64320
ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata 64380
ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct 64440
cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 64500
tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 64560
ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 64620
agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga 64680
gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct 64740
ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata 64800
ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct 64860
cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 64920
tcgatggtct cactaaaata ttttttattc tctttctgat gcatcaacta tttcttaaac 64980
aataacgtcc aacaacatat actcgtcgag cttatcaaca tcccctatgc ccatctaggt 65040
taccagacaa ttgtatatca taaaataatg tttataattt acacgttaaa atcatataat 65100
aaaacgtaga tcgtataata ttttttggta tataaatgat ctagtaaaat ccatgtaggg 65160
gatactgctc acattttttc tttggtacaa aatttcacac aagtttttat acagacaaat 65220
tcttgtccat atattttaaa acattgactt ttgtactaag aaaaatatct agatcaacta 65280
tctctttctc tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatggag 65340
tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat taaacctctt 65400
tctgatggag tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat 65460
taaacctctt tctgatggag tcgtaaaaaa gttttatctc tttctctctt cgatggtctc 65520
acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc tttctctctt 65580
cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc 65640
tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa 65700
gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt ctgatggagt 65760
cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt aaacctcttt 65820
ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt 65880
aaacctcttt ctgatggagt cgtaaaaaag ttttatctct ttctccttcg atggtctcac 65940
aaaaatatta aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctccttcga 66000
tggtctcaca aaaatattaa acctctttct gatggagtcg taaaaaagtt ttatctcttt 66060
ctctcttcga tggtctcaca aaaatattaa acctctttct gatggagtcg taaaaaagtt 66120
ttatctcttt ctctcttcga tggtctcaca aaaatattaa acctctttct gatggtctct 66180
ataaagcgat cgatctttct tacactctag agtttcctac agtcatgggt cacacatttt 66240
tttctagaca ctaaataaaa tatttaaaat ataatattaa tgtactaaaa cttatatatt 66300
attaatttat ctaactaaag ttagtaaatt atatatataa ttttataatt aatttaattt 66360
tactaatttt atttagtgtc tagaaaaaaa 66390
SEQUENCE LISTING
<110> CITY OF HOPE
<120> POXVIRUS-BASED VECTORS PRODUCED BY NATURAL OR SYNTHETIC DNA AND
USES THEREOF
<130> 054435-8200.WO00
<150> US 62/969,628
<151> 2020-02-03
<150> US 63/113,803
<151> 2020-11-13
<160> 18
<170> PatentIn version 3.5
<210> 1
<211> 215
<212> DNA
<213> Artificial Sequence
<220>
<223> terminal CR-HL-CR
<220>
<221> misc_feature
<222> (1)..(20)
<223> poxvirus concatemeric resolution
<220>
<221> misc_feature
<222> (26)..(190)
<223> MVA terminal hairpin loop
<220>
<221> misc_feature
<222> (196)..(215)
<223> poxvirus concatemeric resolution
<400> 1
tttttttcta gacactaaat aaatagtaag attaaattaa ttataaaatt atgtatataa 60
tattaattat aaaattatgt atatgattta ctaactttag ttagataaat taataataca 120
taaattttag tatattaata ttataaatta ataatacata aattttagta tattaatatt 180
atattttaaa tattttatta gtgtctagaa aaaaa 215
<210> 2
<211> 215
<212> DNA
<213> Artificial Sequence
<220>
<223> terminal CR-HL-CR
<220>
<221> misc_feature
<222> (1)..(25)
<223> poxvirus concatemeric resolution
<220>
<221> misc_feature
<222> (26)..(190)
<223> MVA terminal hairpin loop
<220>
<221> misc_feature
<222> (191)..(215)
<223> poxvirus concatemeric resolution
<400> 2
tttttttcta gacactaaat aaatatttaa aatataatat taatatacta aaatttatgt 60
attattaatt tataatatta atatactaaa atttatgtat tattaattta tctaactaaa 120
gttagtaaat catatacata attttataat taatattata tacataattt tataattaat 180
ttaatcttac tatttattta gtgtctagaa aaaaa 215
<210> 3
<211> 165
<212> DNA
<213> Artificial Sequence
<220>
<223> MVA terminal hairpin loop
<400> 3
gtaagattaa attaattata aaattatgta tataatatta attataaaat tatgtatatg 60
atttactaac tttagttaga taaattaata atacataaat tttagtatat taatattata 120
aattaataat acataaattt tagtatatta atattatatt ttaaa 165
<210> 4
<211> 165
<212> DNA
<213> Artificial Sequence
<220>
<223> MVA terminal hairpin loop
<400> 4
tttaaaatat aatattaata tactaaaatt tatgtattat taatttataa tattaatata 60
ctaaaattta tgtattatta atttatctaa ctaaagttag taaatcatat acataatttt 120
ataattaata ttatatacat aattttataa ttaatttaat cttac 165
<210> 5
<211> 154
<212> DNA
<213> Artificial Sequence
<220>
<223> terminal CR-HL-CR
<220>
<221> misc_feature
<222> (1)..(25)
<223> poxvirus concatemeric resolution
<220>
<221> misc_feature
<222> (26)..(129)
<223> Vaccinia terminal hairpin loop
<220>
<221> misc_feature
<222> (130)..(154)
<223> poxvirus concatemeric resolution
<400> 5
tttttttcta gacactaaat aaaatattta aaatataata ttaatgtact aaaacttata 60
tattattaat ttatctaact aaagttagta aattatatat ataattttat aattaattta 120
attttactaa ttttatttag tgtctagaaa aaaa 154
<210> 6
<211> 154
<212> DNA
<213> Artificial Sequence
<220>
<223> terminal CR-HL-CR
<220>
<221> misc_feature
<222> (1)..(25)
<223> poxvirus concatemeric resolution
<220>
<221> misc_feature
<222> (26)..(129)
<223> Vaccinia terminal hairpin loop
<220>
<221> misc_feature
<222> (130)..(154)
<223> poxvirus concatemeric resolution
<400> 6
tttttttcta gacactaaat aaaattagta aaattaaatt aattataaaa ttatatatat 60
aatttactaa ctttagttag ataaattaat aatatataag ttttagtaca ttaatattat 120
attttaaata ttttatttag tgtctagaaa aaaa 154
<210> 7
<211> 104
<212> DNA
<213> Artificial Sequence
<220>
<223> Vaccinia virus terminal hairpin loop
<400> 7
tagtaaaatt aaattaatta taaaattata tatataattt actaacttta gttagataaa 60
ttaataatat ataagtttta gtacattaat attatatttt aaat 104
<210> 8
<211> 104
<212> DNA
<213> Artificial Sequence
<220>
<223> Vaccinia virus terminal hairpin loop
<400> 8
atttaaaata taatattaat gtactaaaac ttatatatta ttaatttatc taactaaagt 60
tagtaaatta tatatataat tttataatta atttaatttt acta 104
<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> MVA concatemer resolution
<400> 9
tttttttcta gacactaaat 20
<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> MVA concatemer resolution
<400> 10
atttagtgtc tagaaaaaaa 20
<210> 11
<211> 60021
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA fragment 1
<400> 11 ggcctagcag gccggccttt ttttctagac actaaataaa tagtaagatt aaattaatta 60 taaaattatg tatataatat taattataaa attatgtata tgatttacta actttagtta 120 gataaattaa taatacataa attttagtat attaatatta taaattaata atacataaat 180 tttagtatat taatattata ttttaaatat ttatttagtg tctagaaaaa aatgtgtgac 240 caacgaccgt aggaaactct agagggtaag aaaaatcaat cgctttatag agaccatcag 300 aaagaggttt aatatttttg tgagaccatc gaaggagaaa gagataaaac ttttttacga 360 ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac 420 ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa 480 gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg 540 aaggagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 600 agaccatcga aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat 660 atttttgtga gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag 720 aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 780 catcagaaag aggtttaata tttttgtgag accatcgaag gagaaagaga taaaactttt 840 ttacgactcc a tcagaaaga ggtttaatat ttttgtgaga ccatcgaaga gagaaagaga 900 ataaaaatat tttagtgaca ccatcagaaa gaggtttaat atttttgtga gaccatcgaa 960 gagagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 1020 gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag aggtttaata 1080 tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc catcagaaag 1140 aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 1200 catcagaaag accatcgaag agagaaagag aaagagatag ttagtctaga tatttttctt 1260 agtacaaaag tcaatgtttt aaaatatatg gacaagaatt tgtctgtata aaaacttgtg 1320 tgaaattttg taccaaagaa aaaatgtgag cagtatcccc tacatggatt ttactagatc 1380 atttatatac caaaaaatat tatacgatct acgttttatt atatgatttt aacgtgtaaa 1440 ttataaacat tattttatga tatacaattg tctggtaacc tagatgggca taggggatga 1500 gtatatgttg ttggacgtta ttgtttaaga aatagttgat gcatcagaaa gaggtttaat 1560 atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttacgact ccatcagaaa 1620 gaggtttaat atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttatgact 1680 ccattgaaga gagaatgag a ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1740 attttttatg agaccatcaa agagagaaag agaataaaaa tattttatga ctccattgaa 1800 gagagaaaga gaaaatgaga ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1860 attttttatg agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt 1920 tatgagacca tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag 1980 accatcaaag agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc 2040 aaagagagaa agagaataaa aatatttttg taaaactttt tttatgagac catcaaagag 2100 agaaagagaa taaaaatatt tttgtaaaac tttttttatg agaccatcaa agagagaaag 2160 agaataaaaa tatttttgta aaactttttt tatgagacca tcaaagagag aaagagaata 2220 aaaatatttt tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata 2280 ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca ccatcagaaa 2340 gaggtttaat atttttgtga gaccatcgaa gagagaaaga gaataaaaat attttatgac 2400 tccattgaag agagaaagag aataaaaata ttttagtgac accatcagaa agaggtttaa 2460 tattttttat gagaccatca aagagagaaa gagaataaaa atatttttgt aaaacttttt 2520 ttatgagacc atcaaagaga gaaa gagaat aaaaatattt ttgtaaaact ttttttatga 2580 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 2640 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 2700 gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 2760 gagaataaaa atattttatg actccattga agagagaatg agaataaaaa tattttagtg 2820 acaccatcag aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa 2880 aatattttat gactccattg aagagagaaa gagaataaaa atattttagt gacaccatca 2940 gaaagaggtt taatattttt tatgagacca tcaaagagag aaagagaata aaaatatttt 3000 tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 3060 acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 3120 tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 3180 agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 3240 tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag accatcaaag 3300 agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc aaagagagaa 3360 agagaataaa aatattttat gactccattg aagagagaat gagaataaaa atattttagt 3420 gacaccatca gaaagaggtt taatattttt gtgagaccat cgaagagaga aagagaataa 3480 aaatatttta tgactccatt gaagagagaa tgagaataaa aatattttag tgacaccatc 3540 agaaagaggt ttaatatttt ttatgagacc atcaaagaga gaaagagaat aaaaatattt 3600 ttgtaaaact ttttttatga gaccatcaaa gagagaaaga gaataaaaat atttttgtaa 3660 aaattataaa cattatttta tgatatacaa ttgtctggta acctagatgg gcatagggga 3720 tgttgataag ctcgacgagt atatgttgtt ggacgttatt gtttaagaaa tagttgatgc 3780 atcagaaaga gaataaaaaa tattttagtg agaccatcga agagagaaag agataaaact 3840 tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 3900 agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 3960 aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 4020 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 4080 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 4140 gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 4200 gagaataaaa atatttttgt aaaacttttt ttatg agacc atcaaagaga gaaagagaat 4260 aaaaatattt tatgactcca ttgaagagag aatgagaata aaaatatttt agtgacacca 4320 tcagaaagag gtttaatatt tttgtgagac catcgaagag agaaagagaa taaaaatatt 4380 ttatgactcc attgaagaga gaatgagaat aaaaatattt tagtgacacc atcagaaaga 4440 ggtttaatat tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 4500 acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 4560 tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 4620 agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 4680 tcaaagagag aaagagaata aaaatatttt atgactccat tgaagagaga atgagaataa 4740 aaatatttta gtgacaccat cagaaagagg tttaatattt ttgtgagacc atcgaagaga 4800 gaaagagaat aaaaatattt tatgactcca ttgaagagag aaagagaata aaaatatttt 4860 agtgacacca tcagaaagag gtttaatatt ttttatgaga ccatcaaaga gagaaagaga 4920 ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa gagaataaaa 4980 atattttatg actccattga agagagaatg agaataaaaa tattttagtg acaccatcag 5040 aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa aatattttat 5100 gactccattg aagagagaat gagaataaaa atattttagt gacaccatca gaaagaggtt 5160 taatattttt gtgagaccat cgaagagaga aagagaataa aaatatttta tgactccatt 5220 gaagagagaa tgagaataaa aatattttag tgacaccatc agaaagaggt ttaatatttt 5280 ttatgagacc atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga 5340 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 5400 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 5460 gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat 5520 ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga 5580 gagaaagaga ataaaaatat tttatgactc cattgaagag agaaagagaa taaaaatatt 5640 ttagtgacac catcagaaag aggtttaata tttttgtgag accatcgaag agagaaagag 5700 aataaaaata ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca 5760 ccatcagaaa gaggtttaat attttttatg agaccatcaa agagagaaag agaataaaaa 5820 tattttttat gagaccatca aagagagaaa gagaataaaa atattttatg agaccatcaa 5880 agagagaaag agaataaaaa tattttttat gagaccatca aagaga gaaa gagaataaaa 5940 atattttatg agaccatcaa agagagaaag agaataaaaa tattttttat gagaccatca 6000 aagagagaaa gagaataaaa atatttttgt atgagaccat cagaaagagg tttaatattt 6060 ttgtgatacc ctgaaaggaa ataggaatag tgtcataatc gtatcacact attgagacag 6120 aaaaagaaga agtcgcgaga ggtaactttt tgttttgcaa accggaatat agtgtccggt 6180 acactttttt aattcgtggt gtgcctgaat cgttcgatta accctactca tccaatttca 6240 gatgaataga gttatcgatt cagacacacg ctttgagttt tgttgaatcg atgagtgaag 6300 tatcatcggt tgcaccttca gatgccgatc cgtcgacata cttgacctca agttcagatg 6360 attccttgca catgtctccg atacgaacgc taaactctag attcttgaca cattttgtat 6420 cgacgatcgt tgaaccgatg atatcttcgt aactcacttt cttatgagag atgttagacc 6480 cgagtactgg atgggtcttg atgtcgctgt ctttctcttc ttcgctacat ctgatgtcga 6540 tagacacctc acagtctttc catcagcgga ttctgagatg gatttaatct gaggacattt 6600 ggtgaatcca aagttcattc tcagacctcc accgatgatg gagtaataag tggtaggagg 6660 atctacatcc tcgactgatt ccacctcggg atctggatct gactcggact ctgtaatttc 6720 cgttacggat tggcaaatct tatcatcggt cggtgtttgg tcttgctttg t gactttgat 6780 aataacatcg attcccatat gatgtttgtt ttcttcttcc gtacacgatg aggatgattg 6840 ctgaagactg gcaggcacat gcatgccagt acgatatatt gtttcatgat tgctattgat 6900 tgagtactgt tctttatgat tctacttcct taccgtgcaa taaattagaa tatattttct 6960 acttttacga gaaattaatt attgtattta tgggtgaaaa acttactata aaaagcgggt 7020 gggtttggaa ttagtgatca gtttatgtat atcgcaacta ccgggcatat ggctacatta 7080 cccacatgat aagagattgt atcagtttcg tagtcttgag tattggtatt actatatagt 7140 atatagatgt cgacgctaga gttactgtct ccgaatgcgg catgatagta tcattctttg 7200 ctttcgttaa ctgtttggag gaagaatctt tgttattgca tttaatctcg aaattcagag 7260 tgcacacctt tctcctgtaa agaaacctga agtcgctacc ttattaagaa gacgggatcg 7320 cagtctttat gattcatagt aatagttagt tccgacgttg agatggattc gctgagaccg 7380 gtagtggtcg tccgagtaca cgatgtgtcg ttaactggat acaggttaat ttccacatcg 7440 atatagttaa aggtatttct gggtacgggt tcgcatttat ctgcggaaga gacggtgtga 7500 gaatatgttc cgagaccaca cggagaacag atgacgtctc cggatactcc gtatcctatt 7560 ccacattttg tttgggaaac acatgccttg catccatgat cgggagagca ttcacag att 7620 ctattgtgag tcgtgttaca cgatcgcgtc gacattgttg acagaaacgt gaccttcatt 7680 cttaccgtcg tccataaata cgttaggtat gtaccacata ctgtcgcgaa cgatgcgtcc 7740 atctcataat gatttacttt ttcataatta aagatgtgaa agaaaaccga acaatatatt 7800 tttttagtaa tgtttatgcg agacatataa aataaactcc gtgtttatga tgccggtaaa 7860 tgtttttatc atcttggacg gaatcgattt tgtaatatgc catggaaaca ggacattatc 7920 actccatgat aaattattta atggagtcga tcctctcatt gttctttgcg tatctcaatc 7980 tgtggcgttt gcttcgttta aataatatat caaacatgga gacgcctgat atgtaggcat 8040 tcttcattct attaatgtct gctctatagc gctttagttc cttatgacga ccggcgatat 8100 catacttact ttagaaggaa aatcatcatc taggattaag gcgtatctga tacaggcgaa 8160 taatggttca ggatatagat agcgtatatc tctattaaat gcgtcaatca tagtctctag 8220 agtgggatgg taactcagta ataaatcaac tagcttctct ttggtaactg cttttctgga 8280 tggccgtatt gattatcgag cgtgacactc gctccatatt ccaataaccg ctttgcaaat 8340 tgtatattat tgacatcgac cgcgtaatat agtagagtta tcgatcatat ctatatcatc 8400 catgtacttg cttagtatat caaatacatc ttcataacag tgatacccgc aattattaaa 84 60 tctcgataat atcagaccgt acatacatag acggccattg ttagatatgt gatttacagc 8520 cgcgtgtcca tattttccac gataaacctt acgacgttta catcgacgag attattatta 8580 acaaagttgt tgtccgtcgt cttatccaac atgcattgaa tgataggtat acttaccata 8640 tcgccgtaat gtaagtagtt tatcagtatg gcttgtacga tggattcatc ctgttgtcta 8700 aatctcttta gaatgttatc gatgatgtag tggttatatt ctctggaatc gtacgaagta 8760 atactacgca ttacgtcgac aagagtatga cgtctctcaa taagaagatt aacgatttcc 8820 atgtctacat tatatggggt tactctaaat cgcttgttta gataatacgc ctctaatata 8880 gggctgacgt cgtatactct acacgtgtcc acatccttta ttaataatct ctatatctat 8940 ggttgagcaa gaccagtagt attggatgga aacattgtta tcgatcaaac atttaattac 9000 atccttggat agagattctc tatgagacga tatatagtaa tgaagagagt tcttacacat 9060 atcactgttg tacatacagg tacgaaatac gtaaccggtg ctgtaacatt ctgatttaag 9120 aagccatagc aatacttctg gtctcggatt aggcgtcgtt acgtatatat ccaccaatcc 9180 gagaccattg attgcataat tcgtattctt ggacggacgt atccgtttat ccacaattag 9240 gtattttagc agacgtaagt cgaaatcatt tatattcgac ttgagttcgt tagaggaatt 9300 cga atagctg gatatcagta gatgcacaat ctgagatttt acgtatctat gcttactgta 9360 tgctcctagc ggagttaatc cttcgttgtt tctacaaagt ctctcgactc cgcgagagag 9420 taacagtcga acaatcttaa tgtctgtatc gcatttattg gagacgtaac aatgtagcgc 9480 attgtttcct cgtctatcta tatgttttga taagttgtga cacgtttcaa tttctagttt 9540 tatttttttg tacgtcacat cttcatccag tagacgacat agaatacatg tgcaatccat 9600 agctattctg gtgctaatta ttcctcataa gatgataaaa agtgtagtga gagagcatga 9660 aggagattta gtatttagca gtgcggatat gatccaagag ggtgagatag tcgttctcgt 9720 tcagaatctt tcgcagcata agtagtatgt cgatatactt atcgttgaag actcttccag 9780 agacgatagc tgattgagta caaagtccaa tgattgcacg aagttcttcg gcggttttca 9840 tggagtcatt tctgatgaaa catttaatga tctaaatttc agtttatgtt tgtaccccgt 9900 attcatactt aacaaattgg tattacatac cattaataat gcaagcataa aaaatcgtta 9960 gtagatgttt ctaaatatag gttccgtaag caaagaatat aagaatgaag cggtaatgat 10020 aaaatcaatc gttatctaaa atgatcatac tcatttattt tattctatta tattaacaca 10080 tacattttta acagcaacac attcaatatt gtattgttat ttttatatta tttacacaat 10140 taacaa tata ttattagttt atattactga attaataata taaaattccc aatcttgtca 10200 taaacacaca ctgagaaaca gcataaacac aaaatccatc aaaaatgttg ataaattatc 10260 tgatgttgtt gttcgctgct atgataatca gatcattcgc cgatagtggt aacgctatcg 10320 aaacgacatc gccagaaatt acaaacgcta caacagatat tccagctatc agattatgcg 10380 gtccagaggg agatggatat tgtttacacg gtgactgtat ccacgctaga gatatcgacg 10440 gtatgtattg tagatgctct catggttata caggcattag atgtcagcat gtagtattag 10500 tagactatca acgttcagaa aaaccaaaca ctacaacgtc atatatccca tctcccggta 10560 ttatgcttgt attagtaggc attattatta ttacgtgttg tctattatct gtttataggt 10620 tcactcgacg aactaaacta cctatacaag atatggttgt gccataattt ttataaattt 10680 tttttatgag tatttttaca aaaatgtata aagtgtatgt cttatgtata tttataaaaa 10740 tgctaaatat gcgatgtatc tatgttattt gtatttatct aaacaatacc tctacctcta 10800 gatattatac aaaaattttt tatttcggca tattaaagta aaatctagtt accttgaaaa 10860 tgaatacagt gggtggttcc gtatcaccag taagaacata atagtcgaat acagtatccg 10920 attgagattt tgcatacaat actagtctag aaagaaattt gtaatcatct tctgtgacgg 1098 0 gagtccatat atctgtatca tcgtcccatg ctatattcct gttatcatca ttagttaatg 11040 aaaataactc tcgtgcttca gaaaagtcaa atattgtatc catacataca tctccaaaac 11100 tatcgcttat acgtttatct ttaacgatac ctatacctag atggttattt actaacagac 11160 attttccaga tctattgact ataactccta tagtttccac atcaaccaag taatgatcat 11220 ctattgttat ataacaataa cataactctt ttccgttttt atcagtatgt atatctatat 11280 caacgtcgtc gttgtagtga atagtagtca ttgatctatt atatgaaacg gatatgtcta 11340 gaacggcaat tgttttacgt ccagttaaca ctttcgttga tttaaagtct agagtctttg 11400 caaacataat atccttatcc gactttatat ttcctgtagg gtggtataat tttattttgc 11460 ctccacatat cggtgtttcc aaatatatta ctagacaata ttccatatag ttattagtta 11520 agggtaccca attagaacac gtacgcttat tatcatcatt tggatcgtat ttcataaaag 11580 ttattgtact atcgatgtca acacattcta cattttttaa tcgtctatat agtatttttc 11640 tgatattttc tataatatca gaattgtctt ccatcggaag ttgtatacta tcggaatcag 11700 ttacatgttt aaataattct ctgatgtcat tccttataca atcaaattca ttattaaaca 11760 gtttaatagt ctgtagacct ttatcgtcgt aaatatccat tgtcttatta gttacgc tta 11820 tttttatgtg tttttacgtt gctttattat attttataag aatgattgtt tgacgaatca 11880 cgagaactat taagacacat tattaggtat atattataaa aaagtttttg attacgatgt 11940 tataagagga aagaggacac attaacatca tacatcaatt aactacattc ttataacatc 12000 gtaatcaaaa gaattgcaat tttgatgtat aacaactgtc aatgggttat ggaattgtat 12060 attacatatt atacggtatg ttggtaacga caaataccga tcggtaattg tctgccggtg 12120 taatagaatt atatatatct atctattaca ccggccttgt atacataata ataagttgtg 12180 gtagtatgat ctccatattt ataatttagg actttgtatt cagttttttt ggaatcataa 12240 aaaataaaaa aaagttttac taatttaaaa ttatttacat ttttttcact gtttagtcgc 12300 ggatatggaa ttcgatcctg ccaaaatcaa tacatcatct atagatcatg taacaatatt 12360 acaatacata gatgaaccaa atgatataag actaacagta tgcattatca caaaaataaa 12420 tccacatttg gctaatcaat ttcgggcttg gaaaaaacgt atcgccggaa gggactatat 12480 gactaactta tctagagata caggaataca acaatcaaaa cttactgaaa ctgtcaaaaa 12540 aatagaaaca tatatggtct atatatacac tacaatttag ttattaattg gataaccgat 12600 gtgattatca atcaatatta agaaggttgg taaattggta catagctaat aatacctata 12660 cacccaataa tacaacaacc atttctgagt tggatatcat caaaatactg gataaatacg 12720 aggacgtgta tagagtaagt aaagaaaaag aatgtgaaat ttgctatgaa gttgtttact 12780 caaaacgata gatactttgg tttattggat tcgtgtaatc atatattttg cataacatgc 12840 atcaatatat ggcatagaac acgaagagaa accggtgcgt cggataattg tcctatatgt 12900 cgtacccgtt ttagaaacat aacaatgagc aagttaacta ataaataaaa agtttaattt 12960 gttgacgacg tatgtcgtta ttttttctcg tataaaagat taatttgatt ctaatataat 13020 ctttagtatt ggataaatat caattcaaat taattccatt agattatatc ataaataaaa 13080 atagtagcac gcactacttc agccaaatat tcttttttga aacgccatct atcgtagtga 13140 ggacacaagt gaacctataa tgagcaaatt tattagtatc ggttacatga aggactttac 13200 gtagagtggt gattccacta tctgtggtac gaacggtttc atcttctttg atgccatcac 13260 ccagatgttc tataaacttg gtatcctttg ccaaccaata catatagcta aactcaggca 13320 tatgttccac acatcctgaa caatgaaatt ctccagaaga tgttacaatg tctagatttg 13380 gacatttggt ttcaaccgcg ttaacatatg agtgaacaca cccatacatg aaagcgatga 13440 gaaataggat tttcatcttg ccaaaatatc actagaaaaa at ttatttat caattttaaa 13500 ggtataaaaa atacttattg ttgctcgaat attttgtatt tgatggtata cggaagatta 13560 gaaatgtagg tattatcatc aactgattct atggttttat gtattctatc atgtttttt tattctatc atgtttttt tggattattatagt attatttt 13620 atttgc tactcacgta attctggatt attgacatat ctatgaataa ttttagctcc atgatcagta 13740 aatattaatg agaacatagt attaccacct accattattt ttttcatctc attcaattct 13800 taattgcaaa gatctatata atcattatag cgttgactta tggactctgg aatcttagac 13860 gatgtacagt catctataat catggcatat ttaatacatt gttttatagc atagtcgtta 13920 tctacgatgt tagatatttc tctcaatgaa tcaatcacac aatctaatgt aggtttatga 13980 cataatagca ttttcagcag ttcaatgttt ttagattcgt tgatggcaat ggctatacat 14040 gtatatccgt tatttgatct aatgttgaca tctgaaccgg attctagcag taaagatact 14100 agagattgtt tattatatct aacagccttg tgaagaagtg tttctcctcg tttgtcaatc 14160 atgttaatgt ctttaagata aggtaggcaa atgtttatag tactaagaat tgggcaagca 14220 taagacatgt cacaaagacc ctttttgtat gtataagtgt aaaaattata acattcatag 14280 ttggatttac ataggtgtcc aatcgggatc tctccatcat cgagataatt gatggcatct 14340 cccttccttt tttagtagat atttcatcgt gtaagaatca atattaatat ttctaaagta 14400 tccgtgtata gcctctttat ttaccacagt tccatattcc actagaggga tatcgccgaa 14460 tgtcatatac tcaattagta tatgttggag gacatccgag ttcattgttt tcaatatca a 14520 aaagatggtt tccttatcat ttctccatag tggtacaata ctacacatta ttccgtgcgg 14580 ctttccattt tccaaaaaca atttgaccaa atctacatct ttattgtatc tataatcact 14640 atttagataa tcagccataa ttactcgagt gcaacatgtt agatcgtcta tatatgaata 14700 agccgtgtta tctattcctt tcattaacaa tttaacgatg tctatatcta tatgagatga 14760 cttaatataa tattgaagag ctgtacaata gtttttatct ataaaagacg gcttgattcc 14820 gtgattaatt agacatttaa caacttccgg acgcacatat gctctcgtat ccgactctga 14880 atacagatga gagatgatat acagatgcaa tacggtaccg caatttcgta gttgataatc 14940 atcatacgcg tatcagtact cgtcctcata aagaacactg cagccatttt ctatgaacaa 15000 atcaataatt tcaggaacag gatcatctgt cattacataa ttttctataa ctgaacgatg 15060 gttttcacat ttaacactca agtcaaatcc atgttctacc aacaccttta tcaagtcaac 15120 gtctacattt ttggatttca tatagctgaa tatattaaag tcatttatgt tgctaaatcc 15180 agtggcttct agtagagcca tcgctatatc ctttaacttt aacatgtcta ctatttgtgt 15240 attcttctaa tggggtagct gtctccaatt tttgcgtaat ggattagtgc cactgtctag 15300 tagtagtttg acgacctcga cattattaca atgctcatta aaaaggtatg c gtgtaaagc 15360 attattcttg aattggttcc tggtatcatt aggatctctg tctctcaaca tctgtttaag 15420 ttcatcgaga gccacctcct cattttccaa atagtcaaac attttgactg aatgagctac 15480 tgtgaactct atacacccac acaactaatg tcattaaata tcatgtcaaa aacttgtaca 15540 attattaata aaaataattt agtgtttaaa ttttaccagt tccagatttt acacctccgt 15600 taaccccact ttttacacca ctggacgatc ctcctcccca cattccaccg ccaccagatg 15660 tataagtttt agatccttta ttactaccat catgtccatg gataaagaca ctccacatgc 15720 cgccactacc ccctttagaa gacatattaa taagacttaa ggacaagttt aacaataaaa 15780 ttaatcacga gtaccctact accaacctac actattatat gattatagtt tctattttta 15840 cagtacctta actaaagtct ctagtcacaa gagcaatact accaacctac actattatat 15900 gattatagtt tctattttta taggaacgcg tacgagaaaa tcaaatgtct aatttctaac 15960 ggtagtgttg ataaacgatt atcgtcaatg gatacctcct ctatcatgtc gtctattttc 16020 ttactttgtt ctattaactt attagcatta tatattattt gattataaaa cttatattgc 16080 ttattagccc aatctgtaaa tatcggatta ttaacatatc gtttctttgt aggtttattt 16140 aacatgtaca tcactgtaag catgtccgta ccatttattt taat ttgacg catatccgca 16200 atttcttttt cgcagtcggt tataaattct atatatgatg gatacatgct acatgtgtac 16260 ttataatcga ctaatatgaa gtacttgata catattttca gtaacgattt attattacca 16320 cctatgaata agtacctgtg atcgtctagg taatcaactg ttttcttaat acattcgatg 16380 gttggtaatt tactcagaat aatttccaat atcttaatat ataattctgc tatttctggg 16440 atatatttat ctgccagtat aacacaaata gtaatacatg taaacccata ttttgttatt 16500 atattaatgt ctgcgccatt atctattaac cattctacta ggctgacact atgcgactta 16560 atacaatgat aaagtatact acatccatgt ttatatcatc aatatacggc ttacaaagtt 16620 ttagtatcga taacacatcc aactcacgca tagagaaggt agggaataat ggcataatat 16680 ttattaggtt atcatcattg tcattatcta caactaagtt tccatttttt aaaatatact 16740 cgacaacttt aggatctcta ttgccaaatt tttgaaaata tttatttata tgcttaaatc 16800 tatataatgt agctccttca tcaatcatac atttaataac attgatgtat actgtatgat 16860 aagatacata ttctaacaat agatcttgta tagaatctgt atatctttta agaattgtgg 16920 atattattac gtaaactatt acacaattct aaaatataaa acgtatcacg gtcgaataat 16980 agttgatcaa ctatataatt atcgattttg tgatttt tct tcctaaactg tttacgtaaa 17040 tagttagata gaatattcat tagttcatga ccactatagt tactatcgaa taacgcgtca 17100 aatatttccc gtttaatatc gcatttgtca agataataat agagtgtggt atgttcacga 17160 taagtataat aacgcatctc tttttcgtgt gaaattaaat agtttattac gtccaaagat 17220 gtagcataac catcttgtga cctagtaata atataataat agagaactgt tttacccatt 17280 ctatcatcat aatcagtggt gtagtcgtaa tcgtaattgt ctaattcatc atcccaatta 17340 taatattcac cagcacgtct aatctgttct attttgatct tgtatccata ctgtatgttg 17400 ctacatgtag gtattccttt atccaataat agtttaaaca catctacatt gggatttgat 17460 gttgtagcgt atttttctac aatattaata ccatttttga tactatttat ttctatacct 17520 ttcgaaatta gtaatttcaa taagtctata tcgatgttat cagaacatag atattcgagt 17580 atatcaaaat cattgatatt tttatagtcg actgacgaca ataacaaaat cacaacatcg 17640 tttttgatat tattattttt cttggtaacg tatgccttta atggagtttc accatcatac 17700 tcatataatg gatttgcacc actttctatc aatgattgtg cactgctggc atcgatgtta 17760 aatgttttac aactatcata gagtatctta tcgttaacca tgattggttg ttgatgctat 17820 cgcatttttt ggtttctttc atttcagtta tgtatggatt tagcacgttt gggaagcatg 17880 agctcatatg atttcagtac tgtagtgtca gtactattag tttcaataag atcaatctct 17940 agatctatag aatcaaaaca cgataggtca gaagataatg aatatctgta ggcttcttgt 18000 tgtactgtaa cttctcgttt tgttagatgt ttgcatcgtg ctttaacatc aatggtacaa 18060 attttatcct cgctttgtgt atcatattcg tccctactat aaaattgtat attcagatta 18120 tcatgagatg tgtatacgct aacggtatca ataaacggag cacaccattt agtcataacc 18180 gtaatccaaa aatttttaaa gtatatctta acgaaagaag ttgtgtcatt gtctacggtg 18240 tatggtacta gatcctcata agtgtatata tctagagtaa tgtttaattt atcaaatggt 18300 tgataatatg gatcctcatg acaatttccg aagatggaaa tgagatatag acatgcaata 18360 aatctaattg cggacatggt tactccttaa aaaaatacga ataatcacct tggctattta 18420 gtaagtgtca tttaacacta tactcatatt aatccatgga ctcataatct ctatacggga 18480 ttaacggatg ttctatatac ggggatgagt agttttcttc tttaacttta tactttttac 18540 taatcatatt tagactgatg tatgggtaat agtgtttaaa gagttcgttc tcatcatcag 18600 aataaatcaa tatctctgtt tttttgttat acagatgtat tacagcctca tatattacgt 18660 aatagaacgt gtcatctacc tt attaactt tcaccgcata gttgtttgca aatacggtta 18720 atcctttgac ctcgtcgatt tccgaccaat ctgggcgtat aatgaatcta aactttaatt 18780 tcttgtaatc attcgaaata atttttagtt tgcatccgta gttatcccct ttatgtaact 18840 gtaaatttct caacgcgata tctccattaa taatgatgtc gaattcgtgc tgtataccca 18900 tactgaatgg atgaacgaat accgacggcg ttaatagtaa tttacttttt catctttaca 18960 tattgggtac tagttttact atcataagtt tataaattcc acaagctact atggaataag 19020 ccaaccatct tagtataaca cacatgtctt aaagtttatt aattaattac atgttgtttt 19080 atatatcgct acgaatttaa acagagaaat cagtttagga aaaaaaaata tctatctaca 19140 tcatcacgtc tctgtattct acgatagagt gctactttaa gatgagacat atccgtgtca 19200 tcaaaaatat actccattaa aatgattatt ccggcagcga acttgatatt ggatatatca 19260 caacctttgt taatatctac gacaatagac agcagtccca tggttccata aacagtgagt 19320 ttatctttct ttgaagagat attttgtaga gatcttataa aactgtcgaa tgacatcgca 19380 tttatatctt tagctaaatc gtatatgtta ccatcgtaat atctaaccgc gtctatctta 19440 aacgtttcca tcgctttaaa gacgtttccg atagatggtc tcatttcatc agtcatactg 19500 agccaacaaa tataa tcgtg tataacatct ttgatagaat cagactctaa agaaaacgaa 19560 tcggctttat tatacgcatt catgataaac ttaatgaaaa atgtttttcg ttgtttaagt 19620 tggatgaata gtatgtctta ataattgtta ttatttcatt aattaatatt tagtaacgag 19680 tacactctat aaaaacgaga atgacataac tagttatcaa agtgtctagg acgcgtaatt 19740 ttcatatggt atagatcctg taagcattgt ctgtattctg gagctatttt ctctatatct 19800 aatttctgaa cgttcaccaa tgtctctagc cactttggca ctaatagcga tcattcgctt 19860 agcgtcttct atattattaa ctggttgatt caatctatct agcaatggac cgtcggacag 19920 cgtcattctc atgttcttaa tcaatgtaca tacatcgccg tcatctacca attcatccaa 19980 caacataagc tttttaaaat catcattata ataggtttga tcgttgtcat ttctccaaag 20040 aatatatcta ataagtagag tcctcatgat tagttaacaa ctatttttta tgttaaatca 20100 attagtacac cgctatgttt aatacttatt catattttag tttttaggat tgagaatcaa 20160 tacaaaaatt aatgcatcat taattttaga aatacttagt ttccacgtag tcaatgaaac 20220 atttgaactc atcgtacagg acgttctcgt acaggacgta actataaacc ggtttatatt 20280 tgttcaagat agatacaaat ccgataactt tttttacgaa ttctacggga tccactttaa 20340 aagtgtca ta ccgggttctt tttatttttt taaacagatt aatggtgtga tgttgattag 20400 gtcttttacg aatttgatat agaatagcgt ttacatattc tccataatgg tcaatcgcca 20460 tttgttcgta tgtcataaat tctttaatta tatgacactg tgtattattt agttcatcct 20520 tgttcatcat taggaatcta tccaatatgg caattatact agaactatag gtgcgttgta 20580 tacacatatt gatgtgtctg tttatacaat ccatgctact accttcgggt aaaattgtag 20640 catcatatac catttctagt actttaggtt cattgttatc cattgcagag gacgtcatga 20700 tcgcatccta aaaaaatata ttatttttat gttattttgt taaaaataat catcgaatac 20760 gaatcatcca gtccactgaa tagcaaaatc tttactattt tggtatcttc caatgtggct 20820 gcctgatgta atggaaattc attctctaga agatttttca atgctccagc gttcaacaac 20880 gtacatacta gacgcacgtt attatcagct attgcataat acaaggcact atgtccatgg 20940 acatccgcct taaatgcatc tttgctagag agaaagcttt tcagctgctt agacttccaa 21000 gtattaattc gtgacagatc catgtctgaa acgagacgct aattagtgta taatttttgt 21060 catattgcac cagaattaat aatatctcta atagatctga ttagtagata catggctatc 21120 gcaaaacaac atatacacat ttaataaaaa taatatttat taagaaaatt cagatttcac 21180 gtacccatca atataaataa aataatgatt ccttacaccg tacccatatt aaggagattc 21240 taccttaccc ataaacaata taaatccagt aatatcatgt ctgatgatga acacaaatgg 21300 tgtattaaat tccagttttt caggagatga tctcgccgta gctaccataa tagtagatgc 21360 ctctgctaca gttccttgtt cgtcgacatc tatctttgca ttctgaaaca ttttataaat 21420 atataatggg tccctagtca tatgtttaaa cgacgcatta tctggattaa acatactagg 21480 agccatcatt tcggctatcg acttaatatc cctcttattt tcgatagaaa atttagggag 21540 tttaagattg tacactttat tccctaattg aaacgaccaa tagtctaatt ttgcagccgt 21600 aatagaatct gtgaaatggg tcatattatc acctattgcc aggtacatac taatattagc 21660 atccttatac ggaaggcgta ccatgtcata ttctttgtca tcgattgtga ttgtatttcc 21720 ttgcaattta gtaactacgt tcatcatggg aaccgttttc gtaccgtact tattagtaaa 21780 actagcattg cgtgttttag tgatatcaaa cggatattgc catatacctt taaaatatat 21840 agtattaatg attgcccata gagtattatt gtcgagcata ttagaatcta ctacattaga 21900 cataccggat ctacgttcta ctatagaatt aattttatta accgcatctc gtctaaagtt 21960 taatctatat aggccgaatc tatgatattg ttgataatac gacggtttaa tacacacag t 22020 attatctacg aaactttgat aagttagatc agtgtacgta tatttagatg ttttcagctt 22080 agctaatcct gatattaatt ctgtaaatgc tggacccaga tctctttttc tcaaatccat 22140 agtcttcaat aattctattc tagtattacc tgatgcaggc aatagcgaca taaacataga 22200 aaacgaataa ccaaacggtg agaagacaat attatcatct tgaatatttt tatacgctac 22260 tataccggca ttggtaaatc cttgtagacg ataggtagac gctgaacacg ttaacgatag 22320 tatcaataac gcaatcatga ttttatggta ttaataatta accttatttt tatgttcggt 22380 ataaaaatta ttgatgtcta cacatccttt tgtaattgac atctatatat ccttttgtat 22440 aatcaactct aatcacttta acttttacag ttttccctac cagtttatcc ctatattcaa 22500 catatctatc catatgcatc ttaacactct ctgccaagat agcttcagag tgaggatagt 22560 caaaaagata aatatataga gcataatcat tctcgtatac tctgcccttt attacatcgc 22620 ccgcattggg caacgaataa caaaatgcaa gcatcttgtt aacgggctcg taaattggga 22680 taaaaattat gtttttatat ctattttatt caagagaata ttcaggaatt tctttttccg 22740 gttgtatctc atcgcagtat atatcatttg tacattgttt catatttttt aatagtttac 22800 accttttagt aggactagta tcgtacaatt catagctgta ttttgaattc c aatcacgca 22860 taaaaatatc ttctaattgt tgacgaagac ctaatccatc atccggtgta atattaatag 22920 atgctccaca tgtatccgta aagtaatttc ctgtccaatt tgaggtacct atataggccg 22980 ttttatcggt taccatatat ttggcatggt ttaccctaga atacggaatg ggaggatcag 23040 catctggtac aataaatagc tttacttcta tatttatgtt tttagatttt agcatagcga 23100 tagatcttaa aaagtttctc atgataaacg aagatcgttg ccagcaacta atcaatagct 23160 taacggatac ttgtctgtct atagcggatc ttcttaattc atcttctata taaggccaaa 23220 acaaaatttt acccgccttc gaataaataa tagggataaa gttcataaca gatacataaa 23280 cgaatttact cgcatttcta atacatgaca ataaagcggt taaatcattg gttctttcca 23340 tagtacatag ttgttgcggt gcagaagcaa taaatacaga gtgtggaaca ccacttacgt 23400 taatactaag aggatgatct gtattataat acgacggata aaagtttttc caattatatg 23460 gtagattgtt aactccaaga taccagtata cctcaaaaat ttgagtgaga tccgctgcca 23520 agttcctatt attgaagatc gcaataccca attctttgac ctgagttagt gatctccaat 23580 ccatgttagc gcttcctaaa taaatatgtg tattatcaga tatccaaaat tttgtatgaa 23640 gaactcctcc taggatattt gtaatatcta tgtatcgtac ttca actccg gccatttgta 23700 gtctttcaac atcctttaat ggtttgttag atttattgac ggctactcta actcgtactc 23760 ctcttttggg taattgtaca atctcgttta atattatcgt gccgaaattc gtacccactt 23820 catccgataa actccaataa aaagatgata tatctagtgt ttttgtggta ttggatagaa 23880 tttccctcca catgttaaat gtagacaaat atactttatc aaattgcata cctataggaa 23940 tagtctctgt aatcactgcg attgtattat ccggattcat tttatttgtt aaaagaataa 24000 tcctatatca cttcactcta ttaaaaatcc aagtttctat ttctttcatg actgattttt 24060 taacttcatc cgtttcctta tgaagatgat gtttggcacc ttcataaatt tttatttctc 24120 tattacaatt tgcatgttgc atgaaataat atgcacctaa aacatcgcta atctcattgt 24180 ttgttccctg gagtatgaga gtcggggtgt taatcttgga aattattttt ctaaccttgt 24240 tggtagcctt caagacctga ctagcaaatc cagccttaat tttttcatga ttgattaatg 24300 ggtcgtattg gtatttataa actttatcca tatctctaga tactgattct ggacatagct 24360 ttccgactgg cgcatttggt gtgatggttc ccataagttt ggcagctagc agattcagtc 24420 ttgaaacagc atctgcatta actagaggag acattagaat cattgctgta aacaagtttg 24480 gattatcgta agaggctagt atagaaattg ttgctcc cat ggaatgaccc aataagtaga 24540 tttaatagtt accacgtgct gtaccaaagt catcaatcat cattttttca ccattacttc 24600 ttccatgtcc aatatgatca tgtgagaata ctaaaattcc taacgatgat atgttttcag 24660 ctagttcgtc ataacgtcca gaatgtttac cagctccatg acttatgaat actaatgcct 24720 taggatatgt aatcattgtc cagattgaac atacagtttg cactcatgat tcacgttata 24780 taactatcaa tattaacagt tcgtttgatg atcatattat ttttatgttt tattgataat 24840 tgtaaaaaca tacaattaaa tcaatataga ggaaggagac ggctactgtc ttttgtgaga 24900 tagtcatggc gactaaatta gattatgagg atgctgtttt ttactttgtg gatgatgata 24960 aaatatgtag tcgcgactcc atcatcgatc taatagatga atatattacg tggagaaatc 25020 atgttatagt gtttaacaaa gatattacca gttgtggaag actgtacaag gaattgatga 25080 agttcgatga tgtcgctata cggtactatg gtattgataa aattaatgag attgtcgaag 25140 ctatgagcga aggagaccac tacatcaatt ttacaaaagt ccatgatcag gaaagtttat 25200 tcgctaccat aggaatatgt gctaaaatca ctgaacattg gggatacaaa aagatttcag 25260 aatctagatt ccaatcattg ggaaacatta cagatctgat gaccgacgat aatataaaca 25320 tcttgatact ttttctagaa aaaaaattga attgatgata taggggtctt cataacgcat 25380 aattattacg ttagcattct atatccgtgt taaaaaaaat tatcctatca tgtatttgag 25440 agttttatat gtagcaaaca tgatagctgt gatgccaata agctttagat attcacgcgt 25500 gctagtgtta gggatggtat tatctggtgg tgaaatgtcc gttatataat ctacaaaaca 25560 atcatcgcat atagtatgcg atagtagagt aaacattttt atagttttta ctggattcat 25620 acatcgtcta cccaattcgg ttatgaatga aattgtcgcc aatcttacac ccaacccctt 25680 gttatccatt agtatagtat taacttcgtt atttatgtca taaactgtaa atgattttgt 25740 agatgccata tcatacatga tattcatgtc cctattataa tcattactaa ctttatcaca 25800 atatatgttg ataatatcta tatatgatct agtctttgtg ggcaactgtc tatacaagtc 25860 gtctaaacgt tgtttactca tatagtatcg aacagccatc attacatggt cccgttccgt 25920 tgatagataa tcgagtatgt tagtggactt gtcaaatcta tataccatat tttctggaag 25980 tggatataca tagtcgtgat caacattatt gctagcctca tcttctatat cctgtactat 26040 accatctaca taatctacga tattattaca cataaacatc gacaacatac tattgtttat 26100 tatctaagtc ctgttgatcc aaacccttga tctcctctat ttgtactatc tagagattgt 26160 acttcttcca gttctggata at atatacgt tgatagatta gctgagctat tctatctcca 26220 gtatttacat taaacgtaca ttttccatta ttaataagaa tgactcctat gtttccccta 26280 taatcttcgt ctattacacc acctcctata tcaatgcctt ttagtgacag accagaccta 26340 ggagctattc taccatagca aatcttaggc atggacatac taatatctgt cttaattaac 26400 tgtctttctc ctggagggat agtataatcg taagcgctat acaaatcata tccggcagca 26460 cccggcgatt gcctagtagg agatttagct ctgttagttt ccttaacaaa tctaactggt 26520 gagttaatat tcatgttgaa cataaaacta atattttatt tcaaaattat ttaccatccc 26580 atatattcca tgaataagtg tgatgattgt acacttctat agtatctata tacgattcac 26640 gataaaatcc tcctatcaat agcagtttat tatccactat gatcaattct ggattatccc 26700 tcggataaat aggatcatct atcagagtcc atgtattgct ggattcacaa taaaattccg 26760 catttctacc aaccaagaat aaccttctac cgaacactaa cgcgcatgat ttataatgag 26820 gataataagt ggatggtcca aactgccact gatcatgatt gggtagcaaa tattctgtag 26880 ttgtatcagt ttcagaatgt cctcccatta cgtatataac attgtttatg gatgccactg 26940 ctggattaca tctaggtttc agaagactcg gcatattaac ccaagcagca tccccgtgga 27000 accaacgctc aacag atgtg ggatttggta gacctcctac tacgtataat ttattgttag 27060 cgggtatccc gctagcatac agtctggggc tattcatcgg aggaattgga atccaattgt 27120 ttgatatata atttacagct atagtacattacgt tatgtattatttt tacctatacgt tatgtattatttc tacctata 27ttcat gatccatgtt cataggatac tctatgaatg gatacttgta tgatttgcgt ggttgtttat 27300 cacaatgaaa tattttggta cagtctagta tccattttac attatttata cctctgggag 27360 aaagataatt tgacctgatt acatttttga taaggagtag cagatttcct aatttatttc 27420 ttcgctttat ataccactta atgacaaaat cctcatctgg aacatttagt tcatcgcttt 27480 ctagaataag tttcatagat agataatcaa aattgtctat gatgtcatct tccagttcca 27540 aaaagtgttt ggcaataaag tttttagtat gacataagag attggatagt ccgtattcta 27600 tacccatcat gtaacactcg acacaatatt cctttctaaa atctcgtagg ataaagttta 27660 tacaagtgta gatgataaat tctacagagg ttaatataga agcacgtaat aaattgacga 27720 cgttatgact atctatatat acctttccag tatatgagta aataactata gaagttagac 27780 tgtgaatgtc aaggtctaga caaaccctcg taactggatc tttatttttc gtgtattttt 27840 gacgtaaatg tgtgcgaaag taaggagata actttttcaa tatcgtagaa ttgactatta 27900 tattgcctcc tatggcatca ataattgttt tgaatttctt agtcatagac aatgctaata 27960 tattcttaca gtacacagta ttgacaaata tcggcattta tgtttcttta aaagtcaaca 28020 tctaaagaaa aatgattatc ttcttgagac ataactccca ttttttggta ttcacccac a 28080 cgtttttcga aaaaattagt tttaccttct aatgatatat tttccatgaa atcaaacgga 28140 ttggtaacat tataaatttt tttaaatccc aattcagaaa tcaatctatc cgcgacgaat 28200 tctatatatg ttttcatcat ttcacaattc attcctataa gtttaactgg aagagccgca 28260 gtaagaaatt cttgttcaat ggataccgca tctgttataa tagatctaac ggtttcttca 28320 ctcggtggat gcaataaatg tttaaacatc aaacatgcga agtcgcagtg tagaccctcg 28380 tctctactaa tcaattcgtt ggaaaacgtg agtccgggca ttaggccacg ctttttaagc 28440 caaaatatgg aagcgaatga tccggaaaag aagattcctt ctactgcagc aaaggcaata 28500 agtctctctc cataaccggc gctgtcatgt atccactttt gagcccaatc ggccttcttt 28560 tttacacaag gcatcgtttc tatggcatta aagagatagt ttttttcatt actatcttta 28620 acataagtat cgatcaaaag actatacatt tccgaatgaa tgttttcaat ggccatctga 28680 aatccgtaga aacatctagc ctcggtaatc tgtacttctg tacaaaatcg ttccgccaaa 28740 ttttcattca ctattccgtc actggctgca aaaaacgcca atacatgttt tataaaatat 28800 ttttcgtctg gtgttagttt attccaatca ttgatatctt tagatatatc tacttcttcc 28860 actgtccaaa atgatgcctc tgccttttta tacatgttcc agatgtcatg a tattggatt 28920 gggaaaataa caaatctatt tggatttggt gcaaggatgg gttccataac taaattaaca 28980 ataacaataa attttttttc agttatctat atgcctgtac ttggatcttt tgtacatcga 29040 tatcgccgca atcactacaa taattacaag tattattgat agcattgtta ttagtactat 29100 cataattaaa ttatcgttat tatcattttg taattgtgac atcatactag ataaatcgtt 29160 tgcgagattg ttgtgggaag cgggcatgga ggatgaatta tcgttattat tatttaaagc 29220 ctcccattcg gattcacaaa tatggcgcgc gttcaacatt ttatggaaac agataacaag 29280 aaaactcgtc atcgttcaaa tttttaacga tagtaaaccg attaaacgtc gagctaattt 29340 ctaacgctag cgactctgtt ggatatgggt ttccagatat atatcttttc agttccccta 29400 cgtatctata atcatctgta ggaaatggaa gatatttcca tttatctact gttcctaata 29460 tcatatgtgg tggtgtagta gaaccattaa gcgcgaaaga tgttatttcg catcgtattt 29520 taacttcgca ataatttctg gttagataac gcactctacc agtcaagtca atgatattag 29580 cctttacaga tatattcata gtagtcgtaa cgatgactcc atcttttaga tgcgatactc 29640 ctttgtatgt accagaatct tcgtacctca aactcgatat atttaaacaa gttaatgaga 29700 tattaacgcg ttttatgaat gatgatatat aaccagaagt ttta tcctcg gtggctagcg 29760 ctataacctt atcattataa taccaactag tgtgattaat atgtgacacg ttagtgtggg 29820 tacaaatatg tacattatcg tctacgtcgt attcgataca tccgcataca gccaacaaat 29880 ataaaatgac aaatactcta acgccgttcg tacccatctt gatgcggttt aataaatgtt 29940 ttgatttcaa tttattgtaa aaaaagattc ggttttatac tgttcgatat tctcattgct 30000 tatattttca tctatcatct ccacacagtc aaatccgtgg ttagcatgca cctcatcaac 30060 cggtaaaaga ctatcggact cttctatcat tataactcta gaatatttaa tttggtcatt 30120 attaatcaag tcaattatct tatttttaac aaacgtgagt attttactca ttttttataa 30180 aaacttttag aaatatacag actctatcgt gtgtctatat cttcttttta tatccaatgt 30240 atttatgtct gatttttctt catttatcat atataatggt ccaaattcta cacgtgcttc 30300 ggattcatcc agatcattaa ggttcttata attgtaacat ccttctcttc cctcttctac 30360 atcttccttc ttattcttat tcttagcgtc acagaatcta ccacagcagg atcccatgac 30420 gagcgtcata ttaaactaat ccattttcaa ttataatata cgattagtaa tgaccattaa 30480 aataaaaata ttcttcataa ccggcaagaa agtgaaaagt tcacattgaa actatgtcag 30540 tagtatacat catgaaatga tgatatatat atactct att ttggtggagg attatatgat 30600 ataattcgtg gataatcatt cttaagacac atttcttcat tcgtaaatct tttcacgtta 30660 aatgagtgtc catattttgc aatttcttca tatgatggcg gtgtacgtgg acgaggctgc 30720 tcctgttctt gttgtagtcg ccgactgtcg tgtctgcgtt tagatccctc cattatcgcg 30780 attgcgtaga tggagtacta ttttatacct tgtaattaaa tttttttatt aattaaacgt 30840 ataaaaacgt tccgtatctg tatttaagag ccagatttcg tctaatagaa caaatagcta 30900 cagtaaaaat aactagaata attgctacac ccactagaaa ccacggatcg taatacggca 30960 atcggttttc gataataggt ggaacgtata ttttatttaa ggacttaaca attgtctgta 31020 aaccacaatt tgcttccgcg gatcctgtat taactatctg taaaagcata tgttgaccgg 31080 gcggagccga acattctccg atatccaatt tctgtatatc tataatatta ttaacctccg 31140 catacgcatt acagttcttt tctagcttgg ataccgcact aggtacatcg tctagatcta 31200 ttcctatttc ctcagcgata gctcttctat ccttttccgg aagcaatgaa atcacttcaa 31260 taaatgattc aaccatgagt gtgaaactaa gtcgagaatt actcatgcat ttgttagtta 31320 ttcggagcgc gcaattttta aactgtccta taacctctcc tatatgaata gcacaagtga 31380 cattagtagg gatagaatgt tgagctaatt tttgtaaata actatctata aaaagattat 31440 acaaagtttt aaactcttta gtttccgcca tttatccagt ctgagaaaat gtctctcata 31500 ataaattttt ccaagaaact aattgggtga agaatggaaa cctttaatct atatttatca 31560 cagtctgttt tggtacacat gatgaattct tccaatgccg tactaaattc gatatctttt 31620 tcgatttctg gatatgtttt taataaagta tgaacaaaga aatggaaatc gtaataccag 31680 ttatgtttaa ctttgaaatt gttttttatt ttcttgttaa tgattccagc cacttgggaa 31740 aagtcaaagt cgtttaatgc cgatttaata cgttcattaa aaacaaactt tttatccttt 31800 agatgaatta ttattggttc attggaatca aaaagtaaga tattatcggg tttaagatct 31860 gcgtgtaaaa agttgtcgca gcatggtagt tcgtaaattt taatgtataa cagagccatc 31920 tgtaaaaaga taaactttat gtattgtacc aaagatttaa atcctaattt gatagctagc 31980 tcggtatcta ctttatctgc cgaatacagt gctaggggaa aaattataat atttcctctt 32040 tcgtattcgt agttagttct cttttcatgt tcgaaaaagt gaaacatgcg gttaaaatag 32100 tttataacat taatattact gttaataact gccggataaa agtgggatag taatttcacg 32160 aatttgatac tgtcctttct ctcgttaaac gcctttaaaa aaactttaga agaatatctc 32220 aatgatagtt cctgaccatc ca tagtttgt atcaataata gcaacatatg aagaacacgt 32280 ttatacagag tatgtaaaaa tgttaattta tagtttaatc ccatggccca cgcacacacg 32340 attaattttt tttcatctcc ctttagattg ttgtatagaa atttgggtac tgtgaactcc 32400 gccgtagttt ccatgggact atataatttt gtggcctcga atacaaattt tactacatag 32460 ttatctatct taaagactat accatatcct cctgtagata tgtgataaaa atcgtcgttt 32520 ataggataaa atcgtttatc cttttgttgg aaaaaggatg aattaatgta atcattctct 32580 tctatcttta gtagtgtttc cttattaaaa ttcttaaaat aatttaacaa tctaactgat 32640 ggagcccaat tttggtgtaa atctaattgg gacattatat tgttaaaata caaacagtct 32700 cctaatataa cagtatctga taatctatgg ggagacatcc attgatattc aggggatgaa 32760 tcattggcaa cacccattta ttgtacaaaa agccccaatt tacaaacgaa agtccaggtt 32820 tgatagagac aaactattaa ctattttgtc tctgttttta atttctttgg taatgaaatt 32880 attcacaata tcagtatctt ctttatctac cagagatttt actaacttga taaccttggc 32940 tgtctcattc aatagggtag taatatttgt atgtgtgata ttgatatctt ttagaagtga 33000 ttctttgatg gtgccagcat acgaattaca ataatgcaga aactcggtta acatgcagga 33060 attatagtaa gccaa ttcca attgttgcct gtgttgtatt agagtgtcaa tatgagcaat 33120 ggtgtccttg cgtttctctg atagaatgcg agcagcgatt ttggcgttat catttgacga 33180 tatttctgga atgacgaatc ctgtttctac taactttttg gtaggacaaa gtgaaacaat 33240 caagaagata gcttctcctc ctatttgtgg aagaaattga actcctctag atgatctcct 33300 tgacagatat tggaccgaat tacagaagta cctggaatgt aaagccctga aaccccctca 33360 ttttttaagc agattgttgc cgtaaatcct gcactatgcc caagatagag agctcctttg 33420 gtgaatccat ctctatgttt cagtttaacc aagaaacagt cagctggtct aaaatttcca 33480 tctctatcta atacagcatc taacttgatg tcaggaacta tgaccggtta tgttatatgt 33540 aacattgagt aaatccttaa gttcataatc atcactgtca tcagttatgt acgatccaaa 33600 caatgtttct actggcatag tggatacgaa gatgctatcc atcagaatgt ttccctgatt 33660 agtattttct atatagctat tcttctttaa acgattttcc aaatcagtaa ctatgttcat 33720 ttttttagga gtaggacgcc tagccagtat ggaagaggat tttctagatc ctctcttcaa 33780 catctttgat ctcaatggaa tgcaaaaccc catagtgtaa caaccaacga taaaaataat 33840 attgtttttc actttttata attttaccat ctgactcatg gattcattaa tatctttata 33900 agagctac ta acgtataatt ctttataact gaactgagat atatacaccg gatctatggt 33960 ttccataatt gagtaaatga atgctcggca ataactaatg gcaaatgtat aaaacaacga 34020 aattatacta gagttgttaa agttaatatt ttctatgagc tgttccaata aattatttgt 34080 tgtaactgcg ttcaagtcat aaatcatctt gatactatcc agtaaaccgt ttttaagttc 34140 tggaatatta ttatcccatt gtaaagcccc taattcgact atcgaatatc ctgctctgat 34200 agcagtttca atatcgacgg acgtcaatac tgtaataaag gtggtagtat tgtcatcatc 34260 gtgataaact actggaatat ggtcgttagt aggtacggta actttacaca acgcgatata 34320 taactttcct tttgtaccat ttttaacgta gttgggacgt cctgcagggt attgttttga 34380 agaaatgata tcgagaacag atttgatacg atatttgttg gattcctgat tatttactat 34440 aatataatct agacagatag atgattcgat aaatagagaa ggtatatcgt tggtaggata 34500 atacatcccc attccagtat tctcggatac tctattaatg acactagtta agaacatgtc 34560 ttctattcta gaaaacgaaa acatcctaca tggactcatt aaaacttcta acgctcctga 34620 ttgtgtctcg aatgcctcgt acaaggattt caaggatgcc atagattctt tgaccaacga 34680 tttagaattg cgtttagcat ctgatttttt tattaaatcg aatggtcggc tctctggttt 34740 gctaccccaa tgataacaat agtcttgtaa agataaaccg caagaaaatt tatacgcatc 34800 catccaaata accctagcac catcggatga tattaatgta ttattataga ttttccatcc 34860 acagttattg ggccagtata ctgttagcaa cggtatatcg aatagattac tcatgtaacc 34920 tactagaatg atagttcgtg tactagtcat aatatcttta atccaatcta agaaatttaa 34980 aattagattt tttacactgt taaagttaac aaaggtatta cccggatacg tggatatcat 35040 atatggtatt ggtccattat cagtaatagc tccataaact gatacggcga tggtttttat 35100 atgtgtttga tctaacgagg aagaaattcg cgcccacaat tcatctctag atatgtattt 35160 aatatcaaac ggtaacacat caatttcggg acgcgtatat gtttctaaat ttttaatcca 35220 aatataatga tgacctatat gccctattat catactgtca actatagtac acctagagaa 35280 cttacgatac atctgtttcc tataatcgtt aaattttaca aatctataac atgctaaacc 35340 ttttgacgac aaccattcat taatttctga tatggaatct gtattctcaa taccgtatcg 35400 ttctaaagcc agtgctatat ctccctgttc gtgagaacgc tttcgtataa tatcgatcaa 35460 cggataatct gaagtttttg gagaataata tgactcatga tctatttcgt ccataaacaa 35520 tctagacata ggaattggag gcgatgatct taattttgtg caatgagtcg tcaatccta t 35580 aacttctaat attgtaatat tcatcatcga cataacacta tctatgttat catcgtatat 35640 tagtatacca tgaccttctt catttcgtgc caaaatgata tacagtctta aatagttacg 35700 caatatctca atagtttcat aattgttagc tgttttcatc aaggtttgta tcctgtttaa 35760 catgatggcg ttctatacgt ttctattttt taaattttta acgatttact gtggctagat 35820 acccaatctc tctcaaatat ttttttagcc tcgcttacaa gctgtttatc tatactatta 35880 aaactgacga atccgtgatt ttggtaatgg gttccgtcga aatttgccga agtgatatga 35940 acatattcgt cgtcgactat caacaatttt gtattattct gaatagtgaa aaccttcaca 36000 gatagatcat tttgaacaca caacgcgtct agacttctgg cggttgccat agaatatacg 36060 tcgttcttat cccaattacc aactagaagt ctgatcttaa ctcctctatt aatggctgct 36120 tctataatgg agttgtaaat gtcgggccaa tagtagctat taccgtcgac acgtgtagtg 36180 ggaactatgg ccaaatgttc aatatctata ctagtcttag ccgacttgag tttatcaata 36240 actacatcag tgtctagatc tctagaatat cccaataggt gttccggaga atcagtaaag 36300 aacactccac ctataggatt cttaatatga tacgcagtgc taactggcag acaacaagcc 36360 gcagagcata aattcaacca tgaatttttt gcgctattaa aggctttaaa a gtatcaaat 36420 cttctacgaa gatctgtggc cagcggggga taatcagaat atacacctaa cgttttaatc 36480 gtatgtatag atcctccagt aaatgacgcg tttcctacat aacatctttc attatctgac 36540 acccaaaaac aaccgagtag tagtcccaca ttattttttt tatctatatt aacggttata 36600 aaatttatat ccgggcagtg actttgtagc tctcccagat ttcttttccc tcgttcatct 36660 agcaaaacta ttattttaat ccctttttca gatgcctctt ttagtttatc aaaaataagc 36720 gctcccctag tcgtactcag aggattacaa caaaaagatg ctatgtatat atatttctta 36780 gctagagtga taatttcgtt aaaacattca aatgttgtta aatgatcgga tctaaaatcc 36840 atattttctg gtagtgtttc taccagccta cattttgctc ccgcaggtac cggtgcaaat 36900 ggccacattt agttaacata aaaacttata catcctgttc tatcaacgat tctagaatat 36960 catcggctat atcgctaaaa ttttcatcaa agtcgacatc acaacctaac tcagtcaata 37020 tattaagaag ttccatgatg tcatcttcgt ctatttctat atccgtatcc attgtagatt 37080 gttgaccgat tatcgagttt aaatcattac taatactcaa tccttcagaa tacaatctgt 37140 gtttcattgt aaatttatag gcggtgtatt taagttggta gattttcaat tatgtatcaa 37200 tatagcaaca gtagttcttg ctcctccttg attctagcat cctc ttcatt attttcttct 37260 acgtacataa acatgtccaa tacgttagac aacacaccga cgatggcggc cgccacagac 37320 acgaatatga ctaaaccgat gaccatttaa aaacccctct ctagctttca cttaaactgt 37380 atcgattatt cttttagaac atgtataata taaaaacatt attctatttc gaatttaggc 37440 ttccaaaaat ttttcatccg taaaccgata ataatatata tagacttgtt aatagtcgga 37500 ataaatagat taatgcttaa actatcatca tctccacgat tagagataca atatttacat 37560 tttttttgct gtttcgaaac tttatcaata cacgttaata caaacccagg aaggagatat 37620 tgaaactgag gctgttgaaa atgaaacggt gaatacaata attcagataa tgtaaaatca 37680 tgattccgta ttctgatgat attagaactg ctaatggatg tcgatggtat gtatctagga 37740 gtatctattt taacaaagca tcgatttgct aatatacaat tatcattttg attaattgtt 37800 attttattca tattcttaaa aggtttcata tttatcaatt cttctacatt aaaaatttcc 37860 atttttaatt tatgtagccc cgcaatactc ctcattacgt ttcatttttt gtctataata 37920 tccattttgt tcatctcggt acatagatta tccaattgag aagcgcattt agtagttttg 37980 tacattttaa gtttattgac gaatcgtcga aaactagtta tagttaacat tttattattt 38040 gataccctga tattaatacc cctgccgtta ctattat tta taactgatgt aatccacgta 38100 acattggaat taactatcga tagtaatgca tcgacgcttc caaaattgtc tattataaac 38160 tcaccgataa tttttttatt acatgttttc atattcatta ggattattaa atctttaatc 38220 ttactacgat tgtatgcgtt gatattgcaa gacgtcattc taaaagacgg aggatctcca 38280 tcaaatgcca gacaatcacg tacaaagtac atggaaatag gttttgttct attgcgcatc 38340 atagatttat atagaacacc cgtagaaata ctaatttgtt ttactctata aaatactaat 38400 gcatctattt catcgttttg tataacgtct ttccaagtgt caaattccaa atttttttca 38460 ttgatagtac caaattcttc tatctcttta actacttgca tagataggta attacagtga 38520 tgcctacatg ccgttttttg aaactgaata gatgcgtcta gaagcgatgc tacgctagtc 38580 acaatcacca ctttcatatt tagaatatat atatgtaaaa atatagtaga atttcatttt 38640 gttttttttc tatgctataa atgaattctc attttgcatc tgctcatact ccgttttata 38700 tcaataccaa agaaggaaga tatctggttc taaaagccgt taaagtatgc gatgttagaa 38760 ctgtagaatg cgaaggaagt aaagcttcct gcgtactcaa agtagataaa ccctcatcac 38820 ccgcgtgtga gagaagacct tcgtcccctt ccagatgcga gagaatgaat aacccaggaa 38880 aacaagttcc gtttatgagg acggacatgc tacaaaatat gttcgcggct aatcgcgata 38940 atgtagcttc tagacttttg tcctaaaata caattatatc cttttcgata ttaataaatc 39000 cgtgtcgtcc aggtttttta tctctttcag tatgtgaata gataggtatt ttatctctat 39060 tcatcatcga atttaagaga tccgataaac attgtttgta ttctccagat gtcagcatct 39120 gatacaacaa tatatgtgca cataaacctc tggcacttat ttcatgtacc ttccccttat 39180 cactaaggag aatagtattt gagaaatatg tatacatgat attatcatga attagatata 39240 cagaatttgt aacactctcg aaatcacacg atgtgtcggc gttaagatct aatatatcac 39300 tcgataacac attttcatct agatacacta gacatttttt aaagctaaaa tagtctttag 39360 tagtaacagt aactatgcga ttattttcat cgatgataca tttcatcggc atattattac 39420 gcttaccatc aaagactata ccatgtgtat atctaacgta ttctagcatg gttgccatac 39480 gcgcattaaa cttttcagga tctttggata gatcttccaa tctatctatt tgagaaaaca 39540 tttttatcat gttcaatagt tgaaacgtcg gatccactat atagatatta tctataaaga 39600 ttttaggaac tacgttcatg gtatcctggc gaatattaaa actatcaatg atatgattat 39660 cgttttcatc ttttatcacc atatagtttc taagatatgg gattttactt aatataatat 39720 tatttcccgt aataaatttt at tagaaatg ccaaatctat aagaaaagtc ctcgaattag 39780 tttgaagaat atctatatcg ccgtaccgta tatttggatt aattagatat agagaatatg 39840 atccgtaaca tatacaactt ttattatggc gtctaagata ttcttccatc aacttattaa 39900 catttttgac tagggaagat acattatgac gtcccattac ttttgccttg tctattactg 39960 cgacgttcat agaatttagc atatctcttg ccaattcttc cattgatgtt acattataag 40020 aaattttaga tgaaattaca tttggagctt taatagtaag aactcctaat atgtccgtgt 40080 atgtggtcac taatacagat tgtagttcta taatcgtaaa taatttacct atattatatg 40140 tttgagtctg tttagaaaag tagctaagta tacgatcttt tatttctgat gcagatgtat 40200 caacatcgga aaaaaatctt tttttattct tttttactaa agatacaaat atgtctttgt 40260 taaaaacagt tattttctga atatttctag cttgtaattt taacatatga tattcgttca 40320 cactaggtac tctgcctaaa taggtttcta taatctttaa tgtaatatta ggaaaagtat 40380 tctgatcagg attcctattc attttgagga tttaaaactc tgattattgt ctaatatggt 40440 ctcaacacaa actttttcac agagcgatag agtttttgat aactcgtttt tcttaagaaa 40500 tataaaacta ctgtctccag agctcgctct atcttttatt ttatttaatt cgatacaaac 40560 tcctgatact ggttc agaaa gtaattcatt aattttcagt cctttataga agatatttaa 40620 tatagataat acaaaatctt cagtttttga tatcgatctg attgatccta gaactagata 40680 tattaataac gtgctgctcatta ggcagtttat gatatta tagattt 740 tatttagtata tattga tatta aaataaatcc aaaataacta gacattctat tttttgtgga ttagtgtact ctcttccctc 40860 tatcatgttc actactggtg tccacgatga taaatatcta gagggaatat aatatagtcc 40920 ataggatgcc aatctagcaa tgtcgaataa ctgtaatttt attcttcgct cttcattatg 40980 aattgattct tgaggtataa acctaacaca aattatatta ttagactttt cgtatgtaat 41040 gtctttcatg ttataagttt ttaatcctgg aatagaatct attttaatga ggcttttaaa 41100 cgcagagttc tccaacgagt caaagcataa tactctgttg gttttcttat atacgatgtt 41160 acgattttct tctttgaatg gaataggttt ttgaattagt ttataattac aacataatag 41220 ataaggaagt gtgcaaatag tacgcggaaa aaacataata gctcccctgt tttcatccat 41280 ggttttaagt aaatgatcac tggcttcttt agtcaatgga tattcgaaca ttaaccgttt 41340 catcatcatt ggacagaatc catatttctt aatgtaaaga gtgatcaaat cattgtgttt 41400 attgtaccat cttgttgtaa atgtgtattc ggttatcgga tctgctcctt tttctattaa 41460 agtatcgatg tcgatctcgt ctaagaattc aactatatcg acatatttca tttgtataca 41520 cataaccatt actaacgtag aatgtatagg aagagatgta acgggaacag ggtttgttga 41580 ttcgcaaact attctaatac ataattcttc tgttaatacg tcttgcacgt aatctatta t 41640 agatgccaag atatctatat aattattttg taagatgatg ttaactatgt gatctatata 41700 agtagtgtaa taattcatgt atttcgatat atgttccaac tctgtctttg tgatgtctag 41760 tttcgtaata tctatagcat cctcaaaaaa tatattcgca tatattccca agtcttcagt 41820 tctatcttct aaaaaatctt caacgtatgg aatataataa tctattttac ctcttctgat 41880 atcattaatg atatagtttt tgacactatc ttctgtcaat tgattcttat tcactatatc 41940 taagaaacgg atagcgtccc taggacgaac tactgccatt aatatctcta ttatagcttc 42000 tggacataat tcatctatta taccagaatt aatgggaact attccgtatc tatctaacat 42060 agttttaaga aagtcagaat ctaagacctg atgttcatat attggttcat acatgaaatg 42120 atctctattg atgatagtga ctatttcatt ctctgaaaat tggtaactca ttctatatat 42180 gctttccttg ttgatgaagg atagaatata ctcaatagaa tttgtaccaa caaactgttc 42240 tcttatgaat cgtatatcat catctgaaat aatcatgtaa ggcatacatt taacaattag 42300 agacttgtct cctgttatca atatactatt cttgtgataa tttatgtgtg aggcaaattt 42360 gtccacgttc tttaattttg ttatagtaga tatcaaatcc aatggagcta cagttcttgg 42420 cttaaacaga tatagttttt ctggaacgaa ttctacaaca ttattataaa g gactttggg 42480 tagataagtg ggatgaaatc ctattttaat taatgcgata gccttgtcct cgtgcagata 42540 tccaaacgct tttgtgatag tatggcattc attgtctaga aacgctctac gaatatctgt 42600 gacagatatc atctttagag aatatactag tcgcgttaat agtactacaa tttgtatttt 42660 ttaatctatc tcaataaaaa aattaatatg tatgattcaa tgtataacta aactactaac 42720 tgttattgat aactagaatc agaatctaat gatgacgtaa ccaagaagtt tatctactgc 42780 caatttagct gcattatttt tagcatctcg tttagatttt ccatctgcct tatcgaatac 42840 tcttccgtcg atatctacac aggcataaaa tgtaggagag ttactaggcc ccactgattc 42900 aatacgaaaa gaccaatctc tcttagttat ttggcagtac tcattaataa tggtgacagg 42960 gttagcatct ttccaatcaa taattttttt agccggaata acatcatcaa aagacttatg 43020 atcctctctc attgattttt cgcgggatac atcatctatt atggcgtcag ccataacatc 43080 agcatccggc ttatccgcct ccgttgtcat aaaccaacga ggaggaatat cgtcggagct 43140 gtacaccata gcactacgtt gaagatcgta cagagcttta ttaacttctc gcttctccat 43200 attaagttgt ctagttagtt gtgcagcagt agctccttcg attccaatgt ttttaatagc 43260 cgcacacaca atctctgcgt cagaacgctc gtcaatatag atct tagaca tttttagaga 43320 gaactaacac aaccagcaat aaaactaatt tattttatca tttttttatt catcatcctc 43380 tggtggttcg tcgtttctat cgaatgtgga tctgattaac ccgtcatcta taggtgatgc 43440 tggttctgga gattctggag gagatggatt attatctgga agaatctctg ttatttcctt 43500 gttttcatgt atcgattgcg ttgtaacatt aagattgcga aatgctctaa atttgggagg 43560 cttaaagtgt tgtttgcaat ctctacacgc atgtctaact agtggaggtt cgtcagcggc 43620 tctagtttga atcatcatcg gcgtagtatt cctactttta cagttaggac acggtgtatt 43680 gtatttctcg tcgagaacgt taaaataatc gttgtaactc acatccttta ttttatctat 43740 attgtattct actcctttct taatgcattt tataccgaat aagagatagc gaaggaattc 43800 tttttcggtg ccgctagtac ccttaatcat atcacatagt gttttatatt ccaaatttgt 43860 ggcaatagac ggtttatttc tatacgatag tttgtttctg gaatcctttg agtattctat 43920 accaatatta ttctttgatt cgaatttagt ttcttcgata ttagattttg tattacctat 43980 attcttgatg tagtactttg atgatttttc catggcccat tctattaagt cttccaagtt 44040 ggcatcatcc acatattgtg atagtaattc tcggatatca gtagcggcta ccgccattga 44100 tgtttgttca ttggatgagt aactactaat gtataca ttt tccatttata acacttatgt 44160 attaactttg ttcatttata ttttttcatt attatgttga tattaacaaa agtgaatata 44220 tatgttaata attgtattgt ggttatacgg ctacaatttc ataatgagtg gaagtcagtg 44280 tccgatgatc aatgacgata gctttactct gaaaagaaag tatcaaatcg atagtgcgga 44340 gtcaacaata aaaatggata agaagaggat aaagtttcag aatagagcca aaatggtaaa 44400 agaaataaat cagacaataa gagcagcaca aactcattac gagacattga aactaggata 44460 cataaaattt aagagaatga ttaggactac tactctagaa gatatagcac catctattcc 44520 aaataatcag aaaacttata aactattctc ggacatttca gccatcggca aagcatcaca 44580 gaatccgagt aagatggtat atgctctgct gctttacatg tttcccaatt tgtttggaga 44640 tgatcataga ttcattcgtt atagaatgca tccaatgagt aaaatcaaac acaagatctt 44700 ctctcctttc aaacttaatc ttattagaat attagtggaa gaaagattct ataataatga 44760 atgcagatct aataaatgga gaataattgg aacacaagtt gataaaatgt tgatagctga 44820 atctgataaa tatacaatag atgcaaggta taacctaaaa cccatgtata gaatcaaggg 44880 aaaatctgaa gaagataccc tctttatcaa acagatggta gaacaatgtg tgacatccca 44940 ggaattggtg gaaaaagtgt tgaagatact gtttagagat ttgttcaaga gtggagaata 45000 caaagcgtac agatacgatg atgatgtaga aaatggattt attggattgg atacactaaa 45060 attaaacatt gttcatgata tagttgaacc atgtatgcct gttcgtaggc cagtggctaa 45120 gatactgtgt aaagaaatgg taaataaata ctttgagaat ccgctacata ttattggtaa 45180 aaatcttcaa gagtgcattg actttgttag tgaataggca tttcatcttt ctccaatact 45240 aattcaaatt gttaaattaa taatggatag tataaatagt tattagtgat aaaatagtaa 45300 aaataattat tagaataaga gtgtagtatc atagataact ctcttctata aaaatggatt 45360 ttattcgtag aaagtatctt atatacacag tagaaaataa tatagatttt ttaaaggatg 45420 atacattaag taaagtaaac aattttaccc tcaatcatgt actagctctc aagtatctag 45480 ttagcaattt tcctcaacac gttattacta aggatgtatt agctaatacc aatttttttg 45540 ttttcataca tatggtacga tgttgtaaag tgtacgaagc ggttttacga cacgcatttg 45600 atgcacccac gttgtacgtt aaagcattga ctaagaatta tttatcgttt agtaacgcaa 45660 tacaatcgta caaggaaacc gtgcataaac taacacaaga tgaaaaattt ttagaggttg 45720 ccgaatacat ggacgaatta ggagaactta taggcgtaaa ttatgactta gttcttaatc 45780 cattatttca cggaggggaa cc catcaaag atatggaaat cattttttta aaactgttta 45840 agaaaacaga cttcaaagtt gttaaaaaat taagtgttat aagattactt atttgggctt 45900 acctaagcaa gaaagataca ggcatagagt ttgcggataa tgatagacaa gatatataca 45960 ctctatttca acaaactggt agaatagtcc atagcaatct aacagaaacg tttagagatt 46020 atatctttcc cggagataag actagctatt gggtgtggtt aaacgaaagt atagctaatg 46080 atgcggatat tgttcttaat agacacgcca ttaccatgta tgataaaatt cttagttata 46140 tatactctga gataaaacaa ggacgcgtta ataaaaacat gcttaagtta gtttatatct 46200 ttgagcctga aaaagatatc agagaacttc tgctagaaat catatatgat attcctggag 46260 atatcctatc tattattgat gcaaaaaacg acgattggaa aaaatatttt attagttttt 46320 ataaagctaa ttttattaac ggtaatacat ttattagtga tagaacgttt aacgaggact 46380 tattcagagt tgttgttcaa atagatcccg aatatttcga taatgaacga attatgtctt 46440 tattctctac gagtgctgcg gacattaaac gatttgatga gttagatatt aataacagtt 46500 atatatctaa tataatttat gaggtgaacg atatcacatt agatacaatg gatgatatga 46560 agaagtgtca aatctttaac gaggatacgt cgtattatgt taaggaatac aatacatacc 46620 tgtttttgca cgagt cggat cccatggtca tagagaacgg aatactaaag aaactgtcat 46680 ctataaaatc caagagtaga cggctgaact tgtttagcaa aaacatttta aaatattatt 46740 tagacggaca attggctcgt ctaggtcttg tgttagatga ttataaagga gacttgttag 46800 ttaaaatgat aaaccatctt aagtctgtgg aggatgtatc cgcattcgtt cgattttcta 46860 cagataaaaa ccctagtatt cttccatcgc taatcaaaac tattttagct agttataata 46920 tttccatcat cgtcttattt caaaggtttt tgagagataa tctatatcat gtagaagaat 46980 tcttggataa aagcatccat ctaaccaaga cggataagaa atatatactt caattgataa 47040 gacacggtag atcatagaac agaccaaata tattattaat aatttgtata tacatagata 47100 taattatcac acatttttga taaatgggaa ctgctgcaac aattcagact cccaccaaat 47160 taatgaataa agaaaatgca gaaatgattt tggaaaaaat tgttgatcat atagttatgt 47220 atattagtga cgaatcaagt gattcagaaa ataatcctga atatattgat tttcgtaaca 47280 gatacgaaga ctatagatct ctcattataa aaagtgatca cgagtttgta aagctatgta 47340 aaaatcatgc agagaaaagt tctccagaaa cgcaacaaat gattatcaaa cacatatacg 47400 aacaatatct tattccagta tctgaagtac tattaaaacc tataatgtcc atgggtgaca 47460 taattaca ta taacggatgt aaagacaatg aatggatgct agaacaactc tctaccctaa 47520 actttaacaa tctccgcaca tggaactcat gtagcatagg caatgtaacg cgtctgtttt 47580 atacattttt tagttatctg atgaaagata aactaaatat ataagtataa tcccattcta 47640 atactttaac ctgatgtatt acctgcatct tattagaata ttaacctaac taaaagacat 47700 aacatagttg ataaaaagcg gtaggatata aatattatgg ctgccaccgt tccgcgtttt 47760 gacgacgtgt acaaaaatgc acaaagaaga attctagatc aagaaacatt ttttagtaga 47820 ggtctaagta gaccgttaat gaaaaacaca tatctatttg ataattacgc gtatggatgg 47880 ataccagaaa ctgcaatttg gagtagtaga tacgcaaact tagatgcaag tgactattat 47940 cccatttcgt tgggattact taaaaagttc gagtttctca tgtctctata taaaggtcct 48000 attcccgtat atgaagaaaa agtaaatact gaattcattg ctaatggatc gttctctggt 48060 agatacgtat catatcttcg aaagttttct gcccttccaa caaacgagtt tattagtttt 48120 ttgttactga cttccattcc aatctataat atcttgttct ggtttaaaaa tactcagttt 48180 gatattacta aacacacatt attcagatac gtctatacag ataatgccaa acacctggcg 48240 ttggctaggt atatgcatca aacaggagac tataagcctt tgtttagtcg tctcaaagag 48300 aattatatat ttaccggtcc cgttccaata agtatcaaag atatagatca ccctaatctt 48360 agtagagcaa gaagtccatc cgattatgag acattagcta atattagtac tatattgtac 48420 tttaccaagt atgatccggt attaatgttt ttattgtttt acgtacctgg gtattcaatt 48480 actacaaaaa ttactccagc cgtagaatat ctaatggata aactgaatct aacaaagagc 48540 gacgtacaac tgttgtaaat tattttatgc ttcgtaaaat gtaggttttg aaccaaacat 48600 tctttcaaag aatgagatgc ataaaacttt attatccaat agattgacta tttcggacgt 48660 caatcgttta aagtaaactt cgtaaaatat tctttgatca ctgccgagtt taaaacttct 48720 atcgataatt gtttcatatg ttttaatatt tacaagtttt ttggtccatg gtacattagc 48780 cggacaaata tatgcaaaat aatatcgttc tccaagttct atagtttctg gattattttt 48840 attatattca gtaaccaaat acatattagg gttatctgcg gatttataat ttgagtgatg 48900 cattcgactc aacataaata attctagagg agacgatcta ctatcaaatt cggatcgtaa 48960 atctgtttct aaagaacgga gaatatctat acatacctga ttagaattca tccgtccttc 49020 agacaacatc tcagacagtc tggtcttgta tgtcttaatc atattcttat gaaacttgga 49080 aacatctctt ctagtttcac tagtaccttt attaattctc tcaggtacag attttgaat t 49140 cgacgatgct gagtatttca tcgttgtata tttcttcttc gattgcataa tcagattctt 49200 atataccgcc tcaaactcta ttttaaaatt attaaacaat actctattat taatcagtcg 49260 ttctaactct ttcgctattt ctatagactt atcgacatct tgactgtcta tctctgtaaa 49320 cacggagtcg gtatctccat acacgctacg aaaacgaaat ctgtaatcta taggcaacga 49380 tgttttcaca atcggattaa tatctctatc gtccatataa aatggattac ttaatggatt 49440 ggcaaaccgt aacataccgt tagataactc tgctccattt agtaccgatt ctagatacaa 49500 gatcattcta cgtcctatgg atgtgcaact cttagccgaa gcgtatgagt atagagcact 49560 atttctaaat cccatcagac catatactga gttggctact atcttgtacg tatattgcat 49620 ggaatcatag atggcctttt cagttgaact ggtagcctgt tttagcatct ttttatatct 49680 ggctctctct gccaaaaatg ttcttaatag tctaggaatg gttccttcta tcgatctatc 49740 gaaaattgct atttcagaga tgaggttcgg tagtctaggt tcacaatgaa ccgtaatata 49800 tctaggaggt ggatatttct gaagcaagag ctgattattt atttcttctt ccaatctatt 49860 ggtactaaca acgacaccga ctaatgtttc cggagataga tttccaaaga tacacacatt 49920 aggatacaga ctgttataat caaagattaa tacattatta ctaaacattt t ttgttttgg 49980 agcaaatacc ttaccgcctt cataaggaaa cttttgtttt gtttctgatc taactaagat 50040 agttttagtt tccaacaata gctttaacag tggacccttg atgactgtac tcgctctata 50100 ttcgaatacc atggattgag gaagcacata tgttgacgca cccgcgtctg tttttgtttc 50160 tactccataa tactcccaca aatactgaca caaacaagca tcatgaatac agtatctagc 50220 catatctaaa gctatgttta gattataatc cttatacatc tgagctaaat caacgtcatc 50280 ctttccgaaa gataatttat atgtatcatt aggtaaagta ggacatgata gtacgacttt 50340 aaatccattt tcccaaatat ctttacgaat tactttacat ataatatcct catcaacagt 50400 cacataatta cctgtggtta aaacctttgc aaatgcagcg gctttgcctt tcgcgtccgt 50460 agtatcgtca ccgatgaacg tcatttctct aactcctcta tttaatactt tacccatgca 50520 actgaacgcg ttcttggata tagaatccaa tttgtacgaa tccaattttt cagatttttg 50580 aatgaatgaa tatagatcga aaaatatagt tccattattg ttattaacgt gaaacgtagt 50640 attggccatg ccgcctactc ccttatgact agactgattt ctctcataaa tacagagatg 50700 tacagcttcc tttttgtccg gagatctaaa gataatcttc tctcctgtta ataactctag 50760 acgattagta atatatctca gatcaaagtt atgtccgtta aagg taacga cgtagtcgaa 50820 cgttagttcc aacaattgtt tagctattcg taacaaaact atttcagaac atagaactag 50880 ttctcgttcg taatccattt ccattagtga ctgtatcctc aaacatcctc tatcgacggc 50940 ttcttgtatt tcctgttccg ttaacatctc ttcattaatg agcgtaaaca ataatcgttt 51000 accacttaaa tcgatataac agtaacttgt atgcgagatt gggttaataa atacagaagg 51060 aaacttctta tcgaagtgac actctatatc tagaaataag tacgatcttg ggatatcgaa 51120 tctaggtatt tttttagcga aacagttacg tggatcgtca caatgataac atccattgtt 51180 aatctttgtc aaatattgct cgtccaacga gtaacatccg tctggagata tcccgttaga 51240 aatataaaac caactaatat tgagaaattc atccatggtg gcattttgta tgctgcgttt 51300 ctttggctct tctatcaacc acatatctgc gacggagcat tttctatctt taatatctag 51360 attataactt attgtctcgt caatgtctat agttctcatc tttcccaacg gcctcgcatt 51420 aaatggagga ggagacaatg actgatatat ttcgtccgta actacgtaat aaaagtaatg 51480 aggaaatcgt ataaatacgg tctcgccatt tcgacatctg gatttcagat ataaaaatct 51540 gttttcaccg tgactttcaa accaattaat gcaccgaaca tccatttata gaatttagaa 51600 atatattttc atttaaatga atcccaaaca ttgggga aga gccgtatgga ccattatttt 51660 tatagtactt tcgcaagcgg gtttagacgg caacatagaa gcgtgtaaac gaaaactata 51720 tactatagtc agcactcttc catgtcctgc atgtagacgg cacgcgacta tcgctataga 51780 ggacaataat gtcatgtcta gcgatgatct gaattatatt tattattttt tcatcagatt 51840 atttaacaat ttggcatctg atcccaaata cgcgatcgat gtgacaaagg ttaacccttt 51900 ataaacttaa cccattataa aacttatgat tagtcacgac tgaaataacc gcgtgattat 51960 tttttggtat aattctacac ggcatggttt ctgtaactat gaattcaacc cccgttacat 52020 tagtgaaatc tttaacaaac agcaagggtt cgtcaaagac ataaaactca ttgtttacaa 52080 tcgaaataga ccccctatca cacttaaaat aaaaaatatc cttatccttt accaccaaat 52140 aaaattctga ttggtcaatg tgaatgtatt cacttaacag ttccacaaat ttatttatta 52200 actccgaggc acatacatcg tcggtatttt ttatggcaaa ctttactctt ccagcatccg 52260 tttctaaaaa aatattaacg agttccattt atatcatcca atattattga aatgacgttg 52320 atggacagat gatacaaata agaaggtacg gtacctttgt ccaccatctc ctccaattca 52380 tgctctattt tgtcattaac tttaatgtat gaaaacagta cgccacatgc ttccatgaca 52440 gtgtgtaaca ctttggatac aaaatgtttg acattagtat aattgtccaa gactgtcaat 52500 ctataataga tagtagctat aatatattct atgatggtat tgaagaagat gacaatcttg 52560 gcatattgat catttaacac agacatggta tcaacagata gcttgaatga aagagaatca 52620 gtaattggaa taagcgtctt ctcgatagag tgtccgtata ccaacatgtc tgatattttg 52680 atgtattcca ttaaattatt tagttttttc tttttattct cgttaaacag catttctgtc 52740 aacggacccc aacatcgttg accgattaag ttttgattga tttttccgtg taaggcgtat 52800 ctagtcagat cgtatagcct atccaataat ccatcatctg tgcgtagatc acatcgtaca 52860 ctttttaatt ctctatagaa gagcgacaga cagcaatttc tttattctct acagatgtaa 52920 gatacttgaa gacattccta tgatgatgca gaattttgga taacacggta ttgatggtat 52980 ctgttaccat aattcctttg atggctgata gtgtcagagc acaagatttc caatctttgt 53040 tttgatatct atatcagaca gcatggtgcg tctgacaaca caaggattaa gacggaaaga 53100 tgaaatgatt ctctcaacat cttcaatgga taccttgcta ttttttctgg cattatctat 53160 atgtgcgaga atatcctcta gagaatcagt atcctttttg atgatagtgg atctcaatga 53220 catgggacgt ctaaaccttc ttattctatc accagattgc atggtgattt gtcttctttc 53280 ttttatcata atgtaatctc ta aattcatc ggcaaattgt ctatatctaa aatcataata 53340 tgagatgttt acctctacaa atatctgttc gtccaatgtt agagtatcta catcagtttt 53400 gtattccaaa ttaaacatgg caacggattt aattttatat tcctctatta agtcctcgtc 53460 gataataaca gaatgtagat aatcatttaa tccatcgtac atggttggaa gatgcttgtt 53520 gacaaaatct ttaattgtct tgatgaaggt gggactatat ctaacatctt gattaataaa 53580 atttataaca ttgtccatag gatactttgt aactagtttt atacacatct cttcatcggt 53640 aagtttagac agaatatcgt gaacaggtgg tatattatat tcatcagata tacgaagaac 53700 aatgtccaaa tctatattgt ttaatatatt atatagatgt agcgtagctc ctacaggaat 53760 atctttaact aagtcaatga tttcatcaac cgttagatct attttaaagt taatcatata 53820 ggcattgatt tttaaaaggt atgtagcctt gactacattc tcattaatta accattccaa 53880 gtcactgtgt gtaagaagat tatattctat cataagcttg actacatttg gtcccgatac 53940 cattaaagaa ttcttatgat ataaggaaac agattttagg tactcatcta ctctacaaga 54000 attttggaga gccttaacga tatcagtgac gtttattatt tcaggaggaa agaatctaac 54060 attgagaata tcggaattaa tagcttccag atacagtgat tttggcaata gtccgtgtaa 54120 tccataatcc agtaa cacga gctggtgctt gctagacacc ttttcaatgt ttaatttttt 54180 tgaaataagc tttgataaag ccttcctcgc aaattccgga tacatgaaca tgtcggcgac 54240 atgattaagt attgtttttt cattattttc tcaacaagtt ctcaataccc caatagatga 54300 tagaatatca cccaatgcgt ccatgttgtc tatttccaac aggtcgctat atccaccaat 54360 agaagttttt ccaaaaaaga ttctaggaac agttctacca ccagtaattt gttcaaaata 54420 gtcacgcaat tcattttcgg gtttaaattc tttaatatcg acaatttcat acgctcctct 54480 tttgaaacta aacttattta gaatatccag tgcatttcta caaaaaggac atgtatactt 54540 gacaaaaatt gtcactttgt tattggccaa cctttgttgt acaaattcct cggccatttt 54600 aatatttaag tgatataaaa ctatctcgac ttatttaact ctttagtcga gatatatgga 54660 cgcagatagc tatatgatag ccaactacag aaggcaaacg ctataaaaaa cataattacg 54720 acgagcatat ttataaatat ttttattcag cattacttga tatagtaata ttaggcacag 54780 tcaaacattc aaccactctc gatacattaa ctctctcatt ttctttaaca aattctacaa 54840 tatcttcgta aaaagattct tgaaactttt tagaatatct atcgactcta gatgaaatag 54900 cgttcgtcaa catactatgt tttgtataca taaaggcgcc cattttaaca gtttctagtg 54960 acaaaatgct agcgatccta ggatccttta gaatcacata gattgacgat tcgtctctct 55020 tagtaactct agtaaaataa tcatacaatc tagtacgcga aataatatta tccttgactt 55080 gaggagatct aaacaatcta gttttgagaa catcgataag ttcatcggga atgacataca 55140 tactatcttt aatagaactc ttttcatcca gttgaatgga ttcgtcctta accaactga t 55200 taatgagatc ttctatttta tcattttcca gatgatatgt atgtccatta aagttaaatt 55260 gtgtagcgct tctttttagt ctagcagcca atactttaac atcactaata tcgatataca 55320 aaggagatga tttatctatg gtattaagaa ttcgtttttc gacatctgtc aaaaccaatt 55380 cctttttgcc tgtatcatcc agttttccat cctttgtaaa gaaattattt tctactagac 55440 tattaataag actgataagg attcctccat aattgcacaa tccaaacttt ttaacaaaac 55500 tagactttac aagatctaca ggaatgcgta attcaggttt cttagcttgt gattttttct 55560 tttgtggaca ttttcttgtg accaactcat ctaccatttc attgatttta gcagtgaaat 55620 aagctttcaa tgcacgggca ctgatactat tgaaaacgag ttgatcttca aattccgcca 55680 tttaagttca ccaaacaact tttaaataca aatatatcaa tagtagtaga ataagaacta 55740 taaaaaaaat aataattaac caataccaac cccaacaacc ggtattatta gttgatgtga 55800 ctgttttctc atcacttaga acagatttaa caatttctat aaagtctgtc aaatcatctt 55860 ccggagaccc cataaataca ccaaatatag cggcgtacaa cttatccatt tatacattga 55920 atattggctt ttctttatcg ctatcttcat catattcatc atcaatatca acaagtccca 55980 gattacgagc cagatcttct tctacatttt cagtcattga tacacgttca c tatctccag 56040 agagtccgat aacgttagcc accacttctc tatcaatgat tagtttcttg agtgcgaatg 56100 taatttttgt ttccgttccg gatctataga agacgatagg tgtgataatt gccttggcca 56160 attgtctttc tcttttactg agtgattcta gttcaccttc tatagatctg agaatggatg 56220 attctccagt cgaaacatat tctaccatgg atccgtttaa tttgttgatg aagatggatt 56280 catccttaaa tgttttctct gtaatagttt ccaccgaaag actatgcaaa gaatttggaa 56340 tgcgttcctt gtgcttaatg tttccataga cggcttctag aagttgatac aacataggac 56400 tagccgcggt aacttttatt tttagaaagt atccatcgct tctatcttgt ttagatttat 56460 ttttataaag tttagtctct ccttccaaca taataaaagt ggaagtcatt tgactagata 56520 aactatcagt aagttttata gagatagacg aacaattagc gtattgagaa gcatttagtg 56580 taacgtattc gatacatttt gcattagatt tactaatcga ttttgcatac tctataacac 56640 ccgcacaagt ctgtagagaa tcgctagatg cagtaggtct tggtgaagtt tcaactctct 56700 tcttgattac cttactcatg attaaaccta aataattgta ctttgtaata taatgatata 56760 tattttcact ttatctcatt tgagaataaa aatgtttttg tttaaccact gcatgatgta 56820 cagatttcgg aatcgcaaac caccagtggt tttattttat cctt gtccaa tgtgaattga 56880 atgggagcgg atgcgggttt cgtacgtaga tagtacattc ccgtttttag accgagactc 56940 catccgtaaa aatgcatact cgttagtttg gaataactcg gatctgctat atggatattc 57000 atagattgac tttgatcgat gaaggctccc ctgtctgcag ccatttttat gatcgtcttt 57060 tgtggaattt cccaaatagt tttataaact cgcttaatat cttctggaag gtttgtattc 57120 tgaatggatc caccatctgc cataatccta ttcttgatct catcattcca taattttctc 57180 tcggttaaaa ctctaaggag atgcggatta actacttgaa attctccaga caatactctc 57240 cgagtgtaaa tattactggt atacggttcc accgactcat tatttcccaa aatttgagca 57300 gttgatgcag tcggcatagg tgccaccaat aaactatttc taagaccgta tgttctgatt 57360 ttatctttta gaggttccca attccaaaga tccgacggta caacattcca aagatcatat 57420 tgtagaatac cgttactggc gtacgatcct acatatgtat cgtatggtcc ttccttctca 57480 gctagttcac aactcgcctc taatgcaccg taataaatgg tttcgaagat cttcttattt 57540 agatcttgtg cttccaggct atcaaatgga taatttaaga gaataaacgc gtccgctaat 57600 ccttgaacac caataccgat aggtctatgt ctcttattag agatttcagc ttctggaata 57660 ggataataat taatatctat aattttattg agatttc tga caattacttt gaccacatcc 57720 ttcagtttga gaaaatcaaa tcgcccatct attacaaaca tgttcaaggc aacagatgcc 57780 agattacaaa cggctacctc attagcatcc gcatattgta ttatctcagt gcaaagatta 57840 ctacacttga tagttcctaa attttgttga ttactctttt tgttacacgc atccttataa 57900 agaatgaatg gagtaccagt ttcaatctga gattctataa tcgctttcca gacgactcga 57960 gcctttatta tagatttgta tctcctttct ctttcgtata gtgtatacaa tcgttcgaac 58020 tcgtctcccc aaacattgtc caatccagga cattcatccg gacacatcaa cgaccactct 58080 ccgtcatcct tcactcgttt cataaagaga tcaggaatcc aaagagctat aaatagatct 58140 ctggttctat gttcctcgtt tcctgtattc tttttaagat cgaggaacgc cataatatca 58200 gaatgccacg gttccaagta tatggccata actccaggcc gtttgtttcc tccctgatct 58260 atgtatctag cggtgttatt ataaactctc aacattggaa taataccgtt tgatatacca 58320 ttggtaccgg agatatagct tccactggca cgaatattac taattgatag acctattccc 58380 cctgccattt tagagattaa tgcgcatcgt tttaacgtgt catagatacc ctctatgcta 58440 tcatcgatca tgttaagtag aaaacagcta gacatttggt gacgactagt tcccgcatta 58500 aataaggtag gagaagcgtg cgtaaaccat ttttcagaaa gtagattgta cgtctcaata 58560 gctgagtcta tatcccattg atgaattcct actgcgacac gcattaacat gtgctgaggt 58620 ctttcaacga tcttgttgtt tattttcaac aagtaggatt tttccaaagt tttaaaacca 58680 aaatagttgt atgaaaagtc tcgttcgtaa ataataaccg agttgagttt atccttatat 58740 ttgttaacta tatccatggt gatacttgaa ataatcggag aatgtttccc atttttagga 58800 ttaacatagt tgaataaatc ctccatcact tcactaaata gtttttttgt ttccttgtgt 58860 agatttgata cggctattct ggcggctaga atggcataat ccggatgttg tgtagtacaa 58920 gtggctgcta tttcggctgc cagagtgtcc aattctaccg ttgttactcc attatatatt 58980 ccttgaataa ccttcatagc tattttaata ggatctatat gatccgtgtt taagccataa 59040 cataattttc taatacgaga cgtgatttta tcaaacatga cattttcctt gtatccattt 59100 cgtttaatga caaacatttt tgttggtgta ataaaaaaaa ttatttaact tttcattaat 59160 agggatttga cgtatgtagc gtacaaaatt atcgttcctg gtatatagat aaagagtcct 59220 atatatttga aaatcgttac ggctcgatta aactttaatg attgcatagt gaatatatca 59280 ttaggattta actccttgac tatcatggcg gcgccagaaa ttaccatcaa aagcattaat 59340 acagttatgc cgatcgcagt ta gaacggtt atagcatcca ccatttatat ctaaaaatta 59400 gatcaaagaa tatgtgacaa agtcctagtt gtatactgag aattgacgaa acaatgtttc 59460 ttacatattt tttttttatt agtaaccgac ttaatagtag gaactggaaa actagacttg 59520 attattctat aagtatagat acccttccaa ataatattct ctttgataaa agttccagaa 59580 aatgtagaat tttttaaaaa gttatctttt gctattacca agattgtgtt tagacgctta 59640 ttattaatat gagtgatgaa atccacaccg cctctagata tcgcttttat ttccacatta 59700 gatggtaaat ccaatagtga aactatcttt ttaggaatgt atggactcgc gtttagagga 59760 gtgaacgtct taggcgtcgg aaaggggccg gccttttttt ctagacacta aataaatagt 59820 aagattaaat taattataaa attatgtata taatattaat tataaaatta tgtatatgat 59880 tactaactt tagttagata aattataataat acataaattta 60 attatatatta atattataaa 59940 cctatta atattataaaa 59940 ttaatagtata atatata <210> 12
<211> 60021
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA fragment F1
<400> 12 ggcctagcag gccggccttt ttttctagac actaaataaa tagtaagatt aaattaatta 60 taaaattatg tatataatat taattataaa attatgtata tgatttacta actttagtta 120 gataaattaa taatacataa attttagtat attaatatta taaattaata atacataaat 180 tttagtatat taatattata ttttaaatat ttatttagtg tctagaaaaa aatgtgtgac 240 caacgaccgt aggaaactct agagggtaag aaaaatcaat cgctttatag agaccatcag 300 aaagaggttt aatatttttg tgagaccatc gaaggagaaa gagataaaac ttttttacga 360 ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac 420 ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa 480 gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg 540 aaggagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 600 agaccatcga aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat 660 atttttgtga gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag 720 aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 780 catcagaaag aggtttaata tttttgtgag accatcgaag gagaaagaga taaaactttt 840 ttacgactcc a tcagaaaga ggtttaatat ttttgtgaga ccatcgaaga gagaaagaga 900 ataaaaatat tttagtgaca ccatcagaaa gaggtttaat atttttgtga gaccatcgaa 960 gagagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 1020 gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag aggtttaata 1080 tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc catcagaaag 1140 aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 1200 catcagaaag accatcgaag agagaaagag aaagagatag ttagtctaga tatttttctt 1260 agtacaaaag tcaatgtttt aaaatatatg gacaagaatt tgtctgtata aaaacttgtg 1320 tgaaattttg taccaaagaa aaaatgtgag cagtatcccc tacatggatt ttactagatc 1380 atttatatac caaaaaatat tatacgatct acgttttatt atatgatttt aacgtgtaaa 1440 ttataaacat tattttatga tatacaattg tctggtaacc tagatgggca taggggatga 1500 gtatatgttg ttggacgtta ttgtttaaga aatagttgat gcatcagaaa gaggtttaat 1560 atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttacgact ccatcagaaa 1620 gaggtttaat atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttatgact 1680 ccattgaaga gagaatgag a ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1740 attttttatg agaccatcaa agagagaaag agaataaaaa tattttatga ctccattgaa 1800 gagagaaaga gaaaatgaga ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1860 attttttatg agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt 1920 tatgagacca tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag 1980 accatcaaag agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc 2040 aaagagagaa agagaataaa aatatttttg taaaactttt tttatgagac catcaaagag 2100 agaaagagaa taaaaatatt tttgtaaaac tttttttatg agaccatcaa agagagaaag 2160 agaataaaaa tatttttgta aaactttttt tatgagacca tcaaagagag aaagagaata 2220 aaaatatttt tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata 2280 ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca ccatcagaaa 2340 gaggtttaat atttttgtga gaccatcgaa gagagaaaga gaataaaaat attttatgac 2400 tccattgaag agagaaagag aataaaaata ttttagtgac accatcagaa agaggtttaa 2460 tattttttat gagaccatca aagagagaaa gagaataaaa atatttttgt aaaacttttt 2520 ttatgagacc atcaaagaga gaaa gagaat aaaaatattt ttgtaaaact ttttttatga 2580 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 2640 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 2700 gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 2760 gagaataaaa atattttatg actccattga agagagaatg agaataaaaa tattttagtg 2820 acaccatcag aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa 2880 aatattttat gactccattg aagagagaaa gagaataaaa atattttagt gacaccatca 2940 gaaagaggtt taatattttt tatgagacca tcaaagagag aaagagaata aaaatatttt 3000 tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 3060 acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 3120 tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 3180 agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 3240 tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag accatcaaag 3300 agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc aaagagagaa 3360 agagaataaa aatattttat gactccattg aagagagaat gagaataaaa atattttagt 3420 gacaccatca gaaagaggtt taatattttt gtgagaccat cgaagagaga aagagaataa 3480 aaatatttta tgactccatt gaagagagaa tgagaataaa aatattttag tgacaccatc 3540 agaaagaggt ttaatatttt ttatgagacc atcaaagaga gaaagagaat aaaaatattt 3600 ttgtaaaact ttttttatga gaccatcaaa gagagaaaga gaataaaaat atttttgtaa 3660 aaattataaa cattatttta tgatatacaa ttgtctggta acctagatgg gcatagggga 3720 tgttgataag ctcgacgagt atatgttgtt ggacgttatt gtttaagaaa tagttgatgc 3780 atcagaaaga gaataaaaaa tattttagtg agaccatcga agagagaaag agataaaact 3840 tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 3900 agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 3960 aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 4020 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 4080 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 4140 gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 4200 gagaataaaa atatttttgt aaaacttttt ttatg agacc atcaaagaga gaaagagaat 4260 aaaaatattt tatgactcca ttgaagagag aatgagaata aaaatatttt agtgacacca 4320 tcagaaagag gtttaatatt tttgtgagac catcgaagag agaaagagaa taaaaatatt 4380 ttatgactcc attgaagaga gaatgagaat aaaaatattt tagtgacacc atcagaaaga 4440 ggtttaatat tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 4500 acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 4560 tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 4620 agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 4680 tcaaagagag aaagagaata aaaatatttt atgactccat tgaagagaga atgagaataa 4740 aaatatttta gtgacaccat cagaaagagg tttaatattt ttgtgagacc atcgaagaga 4800 gaaagagaat aaaaatattt tatgactcca ttgaagagag aaagagaata aaaatatttt 4860 agtgacacca tcagaaagag gtttaatatt ttttatgaga ccatcaaaga gagaaagaga 4920 ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa gagaataaaa 4980 atattttatg actccattga agagagaatg agaataaaaa tattttagtg acaccatcag 5040 aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa aatattttat 5100 gactccattg aagagagaat gagaataaaa atattttagt gacaccatca gaaagaggtt 5160 taatattttt gtgagaccat cgaagagaga aagagaataa aaatatttta tgactccatt 5220 gaagagagaa tgagaataaa aatattttag tgacaccatc agaaagaggt ttaatatttt 5280 ttatgagacc atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga 5340 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 5400 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 5460 gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat 5520 ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga 5580 gagaaagaga ataaaaatat tttatgactc cattgaagag agaaagagaa taaaaatatt 5640 ttagtgacac catcagaaag aggtttaata tttttgtgag accatcgaag agagaaagag 5700 aataaaaata ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca 5760 ccatcagaaa gaggtttaat attttttatg agaccatcaa agagagaaag agaataaaaa 5820 tattttttat gagaccatca aagagagaaa gagaataaaa atattttatg agaccatcaa 5880 agagagaaag agaataaaaa tattttttat gagaccatca aagaga gaaa gagaataaaa 5940 atattttatg agaccatcaa agagagaaag agaataaaaa tattttttat gagaccatca 6000 aagagagaaa gagaataaaa atatttttgt atgagaccat cagaaagagg tttaatattt 6060 ttgtgatacc ctgaaaggaa ataggaatag tgtcataatc gtatcacact attgagacag 6120 aaaaagaaga agtcgcgaga ggtaactttt tgttttgcaa accggaatat agtgtccggt 6180 acactttttt aattcgtggt gtgcctgaat cgttcgatta accctactca tccaatttca 6240 gatgaataga gttatcgatt cagacacacg ctttgagttt tgttgaatcg atgagtgaag 6300 tatcatcggt tgcaccttca gatgccgatc cgtcgacata cttgacctca agttcagatg 6360 attccttgca catgtctccg atacgaacgc taaactctag attcttgaca cattttgtat 6420 cgacgatcgt tgaaccgatg atatcttcgt aactcacttt cttatgagag atgttagacc 6480 cgagtactgg atgggtcttg atgtcgctgt ctttctcttc ttcgctacat ctgatgtcga 6540 tagacacctc acagtctttc catcagcgga ttctgagatg gatttaatct gaggacattt 6600 ggtgaatcca aagttcattc tcagacctcc accgatgatg gagtaataag tggtaggagg 6660 atctacatcc tcgactgatt ccacctcggg atctggatct gactcggact ctgtaatttc 6720 cgttacggat tggcaaatct tatcatcggt cggtgtttgg tcttgctttg t gactttgat 6780 aataacatcg attcccatat gatgtttgtt ttcttcttcc gtacacgatg aggatgattg 6840 ctgaagactg gcaggcacat gcatgccagt acgatatatt gtttcatgat tgctattgat 6900 tgagtactgt tctttatgat tctacttcct taccgtgcaa taaattagaa tatattttct 6960 acttttacga gaaattaatt attgtattta tgggtgaaaa acttactata aaaagcgggt 7020 gggtttggaa ttagtgatca gtttatgtat atcgcaacta ccgggcatat ggctacatta 7080 cccacatgat aagagattgt atcagtttcg tagtcttgag tattggtatt actatatagt 7140 atatagatgt cgacgctaga gttactgtct ccgaatgcgg catgatagta tcattctttg 7200 ctttcgttaa ctgtttggag gaagaatctt tgttattgca tttaatctcg aaattcagag 7260 tgcacacctt tctcctgtaa agaaacctga agtcgctacc ttattaagaa gacgggatcg 7320 cagtctttat gattcatagt aatagttagt tccgacgttg agatggattc gctgagaccg 7380 gtagtggtcg tccgagtaca cgatgtgtcg ttaactggat acaggttaat ttccacatcg 7440 atatagttaa aggtatttct gggtacgggt tcgcatttat ctgcggaaga gacggtgtga 7500 gaatatgttc cgagaccaca cggagaacag atgacgtctc cggatactcc gtatcctatt 7560 ccacattttg tttgggaaac acatgccttg catccatgat cgggagagca ttcacag att 7620 ctattgtgag tcgtgttaca cgatcgcgtc gacattgttg acagaaacgt gaccttcatt 7680 cttaccgtcg tccataaata cgttaggtat gtaccacata ctgtcgcgaa cgatgcgtcc 7740 atctcataat gatttacttt ttcataatta aagatgtgaa agaaaaccga acaatatatt 7800 tttttagtaa tgtttatgcg agacatataa aataaactcc gtgtttatga tgccggtaaa 7860 tgtttttatc atcttggacg gaatcgattt tgtaatatgc catggaaaca ggacattatc 7920 actccatgat aaattattta atggagtcga tcctctcatt gttctttgcg tatctcaatc 7980 tgtggcgttt gcttcgttta aataatatat caaacatgga gacgcctgat atgtaggcat 8040 tcttcattct attaatgtct gctctatagc gctttagttc cttatgacga ccggcgatat 8100 catacttact ttagaaggaa aatcatcatc taggattaag gcgtatctga tacaggcgaa 8160 taatggttca ggatatagat agcgtatatc tctattaaat gcgtcaatca tagtctctag 8220 agtgggatgg taactcagta ataaatcaac tagcttctct ttggtaactg cttttctgga 8280 tggccgtatt gattatcgag cgtgacactc gctccatatt ccaataaccg ctttgcaaat 8340 tgtatattat tgacatcgac cgcgtaatat agtagagtta tcgatcatat ctatatcatc 8400 catgtacttg cttagtatat caaatacatc ttcataacag tgatacccgc aattattaaa 84 60 tctcgataat atcagaccgt acatacatag acggccattg ttagatatgt gatttacagc 8520 cgcgtgtcca tattttccac gataaacctt acgacgttta catcgacgag attattatta 8580 acaaagttgt tgtccgtcgt cttatccaac atgcattgaa tgataggtat acttaccata 8640 tcgccgtaat gtaagtagtt tatcagtatg gcttgtacga tggattcatc ctgttgtcta 8700 aatctcttta gaatgttatc gatgatgtag tggttatatt ctctggaatc gtacgaagta 8760 atactacgca ttacgtcgac aagagtatga cgtctctcaa taagaagatt aacgatttcc 8820 atgtctacat tatatggggt tactctaaat cgcttgttta gataatacgc ctctaatata 8880 gggctgacgt cgtatactct acacgtgtcc acatccttta ttaataatct ctatatctat 8940 ggttgagcaa gaccagtagt attggatgga aacattgtta tcgatcaaac atttaattac 9000 atccttggat agagattctc tatgagacga tatatagtaa tgaagagagt tcttacacat 9060 atcactgttg tacatacagg tacgaaatac gtaaccggtg ctgtaacatt ctgatttaag 9120 aagccatagc aatacttctg gtctcggatt aggcgtcgtt acgtatatat ccaccaatcc 9180 gagaccattg attgcataat tcgtattctt ggacggacgt atccgtttat ccacaattag 9240 gtattttagc agacgtaagt cgaaatcatt tatattcgac ttgagttcgt tagaggaatt 9300 cga atagctg gatatcagta gatgcacaat ctgagatttt acgtatctat gcttactgta 9360 tgctcctagc ggagttaatc cttcgttgtt tctacaaagt ctctcgactc cgcgagagag 9420 taacagtcga acaatcttaa tgtctgtatc gcatttattg gagacgtaac aatgtagcgc 9480 attgtttcct cgtctatcta tatgttttga taagttgtga cacgtttcaa tttctagttt 9540 tatttttttg tacgtcacat cttcatccag tagacgacat agaatacatg tgcaatccat 9600 agctattctg gtgctaatta ttcctcataa gatgataaaa agtgtagtga gagagcatga 9660 aggagattta gtatttagca gtgcggatat gatccaagag ggtgagatag tcgttctcgt 9720 tcagaatctt tcgcagcata agtagtatgt cgatatactt atcgttgaag actcttccag 9780 agacgatagc tgattgagta caaagtccaa tgattgcacg aagttcttcg gcggttttca 9840 tggagtcatt tctgatgaaa catttaatga tctaaatttc agtttatgtt tgtaccccgt 9900 attcatactt aacaaattgg tattacatac cattaataat gcaagcataa aaaatcgtta 9960 gtagatgttt ctaaatatag gttccgtaag caaagaatat aagaatgaag cggtaatgat 10020 aaaatcaatc gttatctaaa atgatcatac tcatttattt tattctatta tattaacaca 10080 tacattttta acagcaacac attcaatatt gtattgttat ttttatatta tttacacaat 10140 taacaa tata ttattagttt atattactga attaataata taaaattccc aatcttgtca 10200 taaacacaca ctgagaaaca gcataaacac aaaatccatc aaaaatgttg ataaattatc 10260 tgatgttgtt gttcgctgct atgataatca gatcattcgc cgatagtggt aacgctatcg 10320 aaacgacatc gccagaaatt acaaacgcta caacagatat tccagctatc agattatgcg 10380 gtccagaggg agatggatat tgtttacacg gtgactgtat ccacgctaga gatatcgacg 10440 gtatgtattg tagatgctct catggttata caggcattag atgtcagcat gtagtattag 10500 tagactatca acgttcagaa aaaccaaaca ctacaacgtc atatatccca tctcccggta 10560 ttatgcttgt attagtaggc attattatta ttacgtgttg tctattatct gtttataggt 10620 tcactcgacg aactaaacta cctatacaag atatggttgt gccataattt ttataaattt 10680 tttttatgag tatttttaca aaaatgtata aagtgtatgt cttatgtata tttataaaaa 10740 tgctaaatat gcgatgtatc tatgttattt gtatttatct aaacaatacc tctacctcta 10800 gatattatac aaaaattttt tatttcggca tattaaagta aaatctagtt accttgaaaa 10860 tgaatacagt gggtggttcc gtatcaccag taagaacata atagtcgaat acagtatccg 10920 attgagattt tgcatacaat actagtctag aaagaaattt gtaatcatct tctgtgacgg 1098 0 gagtccatat atctgtatca tcgtcccatg ctatattcct gttatcatca ttagttaatg 11040 aaaataactc tcgtgcttca gaaaagtcaa atattgtatc catacataca tctccaaaac 11100 tatcgcttat acgtttatct ttaacgatac ctatacctag atggttattt actaacagac 11160 attttccaga tctattgact ataactccta tagtttccac atcaaccaag taatgatcat 11220 ctattgttat ataacaataa cataactctt ttccgttttt atcagtatgt atatctatat 11280 caacgtcgtc gttgtagtga atagtagtca ttgatctatt atatgaaacg gatatgtcta 11340 gaacggcaat tgttttacgt ccagttaaca ctttcgttga tttaaagtct agagtctttg 11400 caaacataat atccttatcc gactttatat ttcctgtagg gtggtataat tttattttgc 11460 ctccacatat cggtgtttcc aaatatatta ctagacaata ttccatatag ttattagtta 11520 agggtaccca attagaacac gtacgcttat tatcatcatt tggatcgtat ttcataaaag 11580 ttattgtact atcgatgtca acacattcta cattttttaa tcgtctatat agtatttttc 11640 tgatattttc tataatatca gaattgtctt ccatcggaag ttgtatacta tcggaatcag 11700 ttacatgttt aaataattct ctgatgtcat tccttataca atcaaattca ttattaaaca 11760 gtttaatagt ctgtagacct ttatcgtcgt aaatatccat tgtcttatta gttacgc tta 11820 tttttatgtg tttttacgtt gctttattat attttataag aatgattgtt tgacgaatca 11880 cgagaactat taagacacat tattaggtat atattataaa aaagtttttg attacgatgt 11940 tataagagga aagaggacac attaacatca tacatcaatt aactacattc ttataacatc 12000 gtaatcaaaa gaattgcaat tttgatgtat aacaactgtc aatgggttat ggaattgtat 12060 attacatatt atacggtatg ttggtaacga caaataccga tcggtaattg tctgccggtg 12120 taatagaatt atatatatct atctattaca ccggccttgt atacataata ataagttgtg 12180 gtagtatgat ctccatattt ataatttagg actttgtatt cagttttttt ggaatcataa 12240 aaaataaaaa aaagttttac taatttaaaa ttatttacat ttttttcact gtttagtcgc 12300 ggatatggaa ttcgatcctg ccaaaatcaa tacatcatct atagatcatg taacaatatt 12360 acaatacata gatgaaccaa atgatataag actaacagta tgcattatca caaaaataaa 12420 tccacatttg gctaatcaat ttcgggcttg gaaaaaacgt atcgccggaa gggactatat 12480 gactaactta tctagagata caggaataca acaatcaaaa cttactgaaa ctgtcaaaaa 12540 aatagaaaca tatatggtct atatatacac tacaatttag ttattaattg gataaccgat 12600 gtgattatca atcaatatta agaaggttgg taaattggta catagctaat aatacctata 12660 cacccaataa tacaacaacc atttctgagt tggatatcat caaaatactg gataaatacg 12720 aggacgtgta tagagtaagt aaagaaaaag aatgtgaaat ttgctatgaa gttgtttact 12780 caaaacgata gatactttgg tttattggat tcgtgtaatc atatattttg cataacatgc 12840 atcaatatat ggcatagaac acgaagagaa accggtgcgt cggataattg tcctatatgt 12900 cgtacccgtt ttagaaacat aacaatgagc aagttaacta ataaataaaa agtttaattt 12960 gttgacgacg tatgtcgtta ttttttctcg tataaaagat taatttgatt ctaatataat 13020 ctttagtatt ggataaatat caattcaaat taattccatt agattatatc ataaataaaa 13080 atagtagcac gcactacttc agccaaatat tcttttttga aacgccatct atcgtagtga 13140 ggacacaagt gaacctataa tgagcaaatt tattagtatc ggttacatga aggactttac 13200 gtagagtggt gattccacta tctgtggtac gaacggtttc atcttctttg atgccatcac 13260 ccagatgttc tataaacttg gtatcctttg ccaaccaata catatagcta aactcaggca 13320 tatgttccac acatcctgaa caatgaaatt ctccagaaga tgttacaatg tctagatttg 13380 gacatttggt ttcaaccgcg ttaacatatg agtgaacaca cccatacatg aaagcgatga 13440 gaaataggat tttcatcttg ccaaaatatc actagaaaaa at ttatttat caattttaaa 13500 ggtataaaaa atacttattg ttgctcgaat attttgtatt tgatggtata cggaagatta 13560 gaaatgtagg tattatcatc aactgattct atggttttat gtattctatc atgtttttt tattctatc atgtttttt tggattattatagt attatttt 13620 atttgc tactcacgta attctggatt attgacatat ctatgaataa ttttagctcc atgatcagta 13740 aatattaatg agaacatagt attaccacct accattattt ttttcatctc attcaattct 13800 taattgcaaa gatctatata atcattatag cgttgactta tggactctgg aatcttagac 13860 gatgtacagt catctataat catggcatat ttaatacatt gttttatagc atagtcgtta 13920 tctacgatgt tagatatttc tctcaatgaa tcaatcacac aatctaatgt aggtttatga 13980 cataatagca ttttcagcag ttcaatgttt ttagattcgt tgatggcaat ggctatacat 14040 gtatatccgt tatttgatct aatgttgaca tctgaaccgg attctagcag taaagatact 14100 agagattgtt tattatatct aacagccttg tgaagaagtg tttctcctcg tttgtcaatc 14160 atgttaatgt ctttaagata aggtaggcaa atgtttatag tactaagaat tgggcaagca 14220 taagacatgt cacaaagacc ctttttgtat gtataagtgt aaaaattata acattcatag 14280 ttggatttac ataggtgtcc aatcgggatc tctccatcat cgagataatt gatggcatct 14340 cccttccttt tttagtagat atttcatcgt gtaagaatca atattaatat ttctaaagta 14400 tccgtgtata gcctctttat ttaccacagt tccatattcc actagaggga tatcgccgaa 14460 tgtcatatac tcaattagta tatgttggag gacatccgag ttcattgttt tcaatatca a 14520 aaagatggtt tccttatcat ttctccatag tggtacaata ctacacatta ttccgtgcgg 14580 ctttccattt tccaaaaaca atttgaccaa atctacatct ttattgtatc tataatcact 14640 atttagataa tcagccataa ttactcgagt gcaacatgtt agatcgtcta tatatgaata 14700 agccgtgtta tctattcctt tcattaacaa tttaacgatg tctatatcta tatgagatga 14760 cttaatataa tattgaagag ctgtacaata gtttttatct ataaaagacg gcttgattcc 14820 gtgattaatt agacatttaa caacttccgg acgcacatat gctctcgtat ccgactctga 14880 atacagatga gagatgatat acagatgcaa tacggtaccg caatttcgta gttgataatc 14940 atcatacgcg tatcagtact cgtcctcata aagaacactg cagccatttt ctatgaacaa 15000 atcaataatt tcaggaacag gatcatctgt cattacataa ttttctataa ctgaacgatg 15060 gttttcacat ttaacactca agtcaaatcc atgttctacc aacaccttta tcaagtcaac 15120 gtctacattt ttggatttca tatagctgaa tatattaaag tcatttatgt tgctaaatcc 15180 agtggcttct agtagagcca tcgctatatc ctttaacttt aacatgtcta ctatttgtgt 15240 attcttctaa tggggtagct gtctccaatt tttgcgtaat ggattagtgc cactgtctag 15300 tagtagtttg acgacctcga cattattaca atgctcatta aaaaggtatg c gtgtaaagc 15360 attattcttg aattggttcc tggtatcatt aggatctctg tctctcaaca tctgtttaag 15420 ttcatcgaga gccacctcct cattttccaa atagtcaaac attttgactg aatgagctac 15480 tgtgaactct atacacccac acaactaatg tcattaaata tcatgtcaaa aacttgtaca 15540 attattaata aaaataattt agtgtttaaa ttttaccagt tccagatttt acacctccgt 15600 taaccccact ttttacacca ctggacgatc ctcctcccca cattccaccg ccaccagatg 15660 tataagtttt agatccttta ttactaccat catgtccatg gataaagaca ctccacatgc 15720 cgccactacc ccctttagaa gacatattaa taagacttaa ggacaagttt aacaataaaa 15780 ttaatcacga gtaccctact accaacctac actattatat gattatagtt tctattttta 15840 cagtacctta actaaagtct ctagtcacaa gagcaatact accaacctac actattatat 15900 gattatagtt tctattttta taggaacgcg tacgagaaaa tcaaatgtct aatttctaac 15960 ggtagtgttg ataaacgatt atcgtcaatg gatacctcct ctatcatgtc gtctattttc 16020 ttactttgtt ctattaactt attagcatta tatattattt gattataaaa cttatattgc 16080 ttattagccc aatctgtaaa tatcggatta ttaacatatc gtttctttgt aggtttattt 16140 aacatgtaca tcactgtaag catgtccgta ccatttattt taat ttgacg catatccgca 16200 atttcttttt cgcagtcggt tataaattct atatatgatg gatacatgct acatgtgtac 16260 ttataatcga ctaatatgaa gtacttgata catattttca gtaacgattt attattacca 16320 cctatgaata agtacctgtg atcgtctagg taatcaactg ttttcttaat acattcgatg 16380 gttggtaatt tactcagaat aatttccaat atcttaatat ataattctgc tatttctggg 16440 atatatttat ctgccagtat aacacaaata gtaatacatg taaacccata ttttgttatt 16500 atattaatgt ctgcgccatt atctattaac cattctacta ggctgacact atgcgactta 16560 atacaatgat aaagtatact acatccatgt ttatatcatc aatatacggc ttacaaagtt 16620 ttagtatcga taacacatcc aactcacgca tagagaaggt agggaataat ggcataatat 16680 ttattaggtt atcatcattg tcattatcta caactaagtt tccatttttt aaaatatact 16740 cgacaacttt aggatctcta ttgccaaatt tttgaaaata tttatttata tgcttaaatc 16800 tatataatgt agctccttca tcaatcatac atttaataac attgatgtat actgtatgat 16860 aagatacata ttctaacaat agatcttgta tagaatctgt atatctttta agaattgtgg 16920 atattattac gtaaactatt acacaattct aaaatataaa acgtatcacg gtcgaataat 16980 agttgatcaa ctatataatt atcgattttg tgatttt tct tcctaaactg tttacgtaaa 17040 tagttagata gaatattcat tagttcatga ccactatagt tactatcgaa taacgcgtca 17100 aatatttccc gtttaatatc gcatttgtca agataataat agagtgtggt atgttcacga 17160 taagtataat aacgcatctc tttttcgtgt gaaattaaat agtttattac gtccaaagat 17220 gtagcataac catcttgtga cctagtaata atataataat agagaactgt tttacccatt 17280 ctatcatcat aatcagtggt gtagtcgtaa tcgtaattgt ctaattcatc atcccaatta 17340 taatattcac cagcacgtct aatctgttct attttgatct tgtatccata ctgtatgttg 17400 ctacatgtag gtattccttt atccaataat agtttaaaca catctacatt gggatttgat 17460 gttgtagcgt atttttctac aatattaata ccatttttga tactatttat ttctatacct 17520 ttcgaaatta gtaatttcaa taagtctata tcgatgttat cagaacatag atattcgagt 17580 atatcaaaat cattgatatt tttatagtcg actgacgaca ataacaaaat cacaacatcg 17640 tttttgatat tattattttt cttggtaacg tatgccttta atggagtttc accatcatac 17700 tcatataatg gatttgcacc actttctatc aatgattgtg cactgctggc atcgatgtta 17760 aatgttttac aactatcata gagtatctta tcgttaacca tgattggttg ttgatgctat 17820 cgcatttttt ggtttctttc atttcagtta tgtatggatt tagcacgttt gggaagcatg 17880 agctcatatg atttcagtac tgtagtgtca gtactattag tttcaataag atcaatctct 17940 agatctatag aatcaaaaca cgataggtca gaagataatg aatatctgta ggcttcttgt 18000 tgtactgtaa cttctcgttt tgttagatgt ttgcatcgtg ctttaacatc aatggtacaa 18060 attttatcct cgctttgtgt atcatattcg tccctactat aaaattgtat attcagatta 18120 tcatgagatg tgtatacgct aacggtatca ataaacggag cacaccattt agtcataacc 18180 gtaatccaaa aatttttaaa gtatatctta acgaaagaag ttgtgtcatt gtctacggtg 18240 tatggtacta gatcctcata agtgtatata tctagagtaa tgtttaattt atcaaatggt 18300 tgataatatg gatcctcatg acaatttccg aagatggaaa tgagatatag acatgcaata 18360 aatctaattg cggacatggt tactccttaa aaaaatacga ataatcacct tggctattta 18420 gtaagtgtca tttaacacta tactcatatt aatccatgga ctcataatct ctatacggga 18480 ttaacggatg ttctatatac ggggatgagt agttttcttc tttaacttta tactttttac 18540 taatcatatt tagactgatg tatgggtaat agtgtttaaa gagttcgttc tcatcatcag 18600 aataaatcaa tatctctgtt tttttgttat acagatgtat tacagcctca tatattacgt 18660 aatagaacgt gtcatctacc tt attaactt tcaccgcata gttgtttgca aatacggtta 18720 atcctttgac ctcgtcgatt tccgaccaat ctgggcgtat aatgaatcta aactttaatt 18780 tcttgtaatc attcgaaata atttttagtt tgcatccgta gttatcccct ttatgtaact 18840 gtaaatttct caacgcgata tctccattaa taatgatgtc gaattcgtgc tgtataccca 18900 tactgaatgg atgaacgaat accgacggcg ttaatagtaa tttacttttt catctttaca 18960 tattgggtac tagttttact atcataagtt tataaattcc acaagctact atggaataag 19020 ccaaccatct tagtataaca cacatgtctt aaagtttatt aattaattac atgttgtttt 19080 atatatcgct acgaatttaa acagagaaat cagtttagga aaaaaaaata tctatctaca 19140 tcatcacgtc tctgtattct acgatagagt gctactttaa gatgagacat atccgtgtca 19200 tcaaaaatat actccattaa aatgattatt ccggcagcga acttgatatt ggatatatca 19260 caacctttgt taatatctac gacaatagac agcagtccca tggttccata aacagtgagt 19320 ttatctttct ttgaagagat attttgtaga gatcttataa aactgtcgaa tgacatcgca 19380 tttatatctt tagctaaatc gtatatgtta ccatcgtaat atctaaccgc gtctatctta 19440 aacgtttcca tcgctttaaa gacgtttccg atagatggtc tcatttcatc agtcatactg 19500 agccaacaaa tataa tcgtg tataacatct ttgatagaat cagactctaa agaaaacgaa 19560 tcggctttat tatacgcatt catgataaac ttaatgaaaa atgtttttcg ttgtttaagt 19620 tggatgaata gtatgtctta ataattgtta ttatttcatt aattaatatt tagtaacgag 19680 tacactctat aaaaacgaga atgacataac tagttatcaa agtgtctagg acgcgtaatt 19740 ttcatatggt atagatcctg taagcattgt ctgtattctg gagctatttt ctctatatct 19800 aatttctgaa cgttcaccaa tgtctctagc cactttggca ctaatagcga tcattcgctt 19860 agcgtcttct atattattaa ctggttgatt caatctatct agcaatggac cgtcggacag 19920 cgtcattctc atgttcttaa tcaatgtaca tacatcgccg tcatctacca attcatccaa 19980 caacataagc tttttaaaat catcattata ataggtttga tcgttgtcat ttctccaaag 20040 aatatatcta ataagtagag tcctcatgat tagttaacaa ctatttttta tgttaaatca 20100 attagtacac cgctatgttt aatacttatt catattttag tttttaggat tgagaatcaa 20160 tacaaaaatt aatgcatcat taattttaga aatacttagt ttccacgtag tcaatgaaac 20220 atttgaactc atcgtacagg acgttctcgt acaggacgta actataaacc ggtttatatt 20280 tgttcaagat agatacaaat ccgataactt tttttacgaa ttctacggga tccactttaa 20340 aagtgtca ta ccgggttctt tttatttttt taaacagatt aatggtgtga tgttgattag 20400 gtcttttacg aatttgatat agaatagcgt ttacatattc tccataatgg tcaatcgcca 20460 tttgttcgta tgtcataaat tctttaatta tatgacactg tgtattattt agttcatcct 20520 tgttcatcat taggaatcta tccaatatgg caattatact agaactatag gtgcgttgta 20580 tacacatatt gatgtgtctg tttatacaat ccatgctact accttcgggt aaaattgtag 20640 catcatatac catttctagt actttaggtt cattgttatc cattgcagag gacgtcatga 20700 acgcatccta aaaaaatata ttatttttat gttattttgt taaaaataat catcgaatac 20760 gaatcatcca gtccactgaa tagcaaaatc tttactattt tggtatcttc caatgtggct 20820 gcctgatgta atggaaattc attctctaga agatttttca atgctccagc gttcaacaac 20880 gtacatacta gacgcacgtt attatcagct attgcataat acaaggcact atgtccatgg 20940 acatccgcct taaatgcatc tttgctagag agaaagcttt tcagctgctt agacttccaa 21000 gtattaattc gtgacagatc catgtctgaa acgagacgct aattagtgta taatttttgt 21060 catattgcac cagaattaat aatatctcta atagatctga ttagtagata catggctatc 21120 gcaaaacaac atatacacat ttaataaaaa taatatttat taagaaaatt cagatttcac 21180 gtacccatca atataaataa aataatgatt ccttacaccg tacccatatt aaggagattc 21240 taccttaccc ataaacaata taaatccagt aatatcatgt ctgatgatga acacaaatgg 21300 tgtattaaat tccagttttt caggagatga tctcgccgta gctaccataa tagtagatgc 21360 ctctgctaca gttccttgtt cgtcgacatc tatctttgca ttctgaaaca ttttataaat 21420 atataatggg tccctagtca tatgtttaaa cgacgcatta tctggattaa acatactagg 21480 agccatcatt tcggctatcg acttaatatc cctcttattt tcgatagaaa atttagggag 21540 tttaagattg tacactttat tccctaattg aaacgaccaa tagtctaatt ttgcagccgt 21600 aatagaatct gtgaaatggg tcatattatc acctattgcc aggtacatac taatattagc 21660 atccttatac ggaaggcgta ccatgtcata ttctttgtca tcgattgtga ttgtatttcc 21720 ttgcaattta gtaactacgt tcatcatggg aaccgttttc gtaccgtact tattagtaaa 21780 actagcattg cgtgttttag tgatatcaaa cggatattgc catatacctt taaaatatat 21840 agtattaatg attgcccata gagtattatt gtcgagcata ttagaatcta ctacattaga 21900 cataccggat ctacgttcta ctatagaatt aattttatta accgcatctc gtctaaagtt 21960 taatctatat aggccgaatc tatgatattg ttgataatac gacggtttaa tacacacag t 22020 attatctacg aaactttgat aagttagatc agtgtacgta tatttagatg ttttcagctt 22080 agctaatcct gatattaatt ctgtaaatgc tggacccaga tctctttttc tcaaatccat 22140 agtcttcaat aattctattc tagtattacc tgatgcaggc aatagcgaca taaacataga 22200 aaacgaataa ccaaacggtg agaagacaat attatcatct tgaatatttt tatacgctac 22260 tataccggca ttggtaaatc cttgtagacg ataggtagac gctgaacacg ttaacgatag 22320 tatcaataac gcaatcatga ttttatggta ttaataatta accttatttt tatgttcggt 22380 ataaaaatta ttgatgtcta cacatccttt tgtaattgac atctatatat ccttttgtat 22440 aatcaactct aatcacttta acttttacag ttttccctac cagtttatcc ctatattcaa 22500 catatctatc catatgcatc ttaacactct ctgccaagat agcttcagag tgaggatagt 22560 caaaaagata aatatataga gcataatcat tctcgtatac tctgcccttt attacatcgc 22620 ccgcattggg caacgaataa caaaatgcaa gcatcttgtt aacgggctcg taaattggga 22680 taaaaattat gtttttatat ctattttatt caagagaata ttcaggaatt tctttttccg 22740 gttgtatctc atcgcagtat atatcatttg tacattgttt catatttttt aatagtttac 22800 accttttagt aggactagta tcgtacaatt catagctgta ttttgaattc c aatcacgca 22860 taaaaatatc ttctaattgt tgacgaagac ctaatccatc atccggtgta atattaatag 22920 atgctccaca tgtatccgta aagtaatttc ctgtccaatt tgaggtacct atataggccg 22980 ttttatcggt taccatatat ttggcatggt ttaccctaga atacggaatg ggaggatcag 23040 catctggtac aataaatagc tttacttcta tatttatgtt tttagatttt agcatagcga 23100 tagatcttaa aaagtttctc atgataaacg aagatcgttg ccagcaacta atcaatagct 23160 taacggatac ttgtctgtct atagcggatc ttcttaattc atcttctata taaggccaaa 23220 acaaaatttt acccgccttc gaataaataa tagggataaa gttcataaca gatacataaa 23280 cgaatttact cgcatttcta atacatgaca ataaagcggt taaatcattg gttctttcca 23340 tagtacatag ttgttgcggt gcagaagcaa taaatacaga gtgtggaaca ccacttacgt 23400 taatactaag aggatgatct gtattataat acgacggata aaagtttttc caattatatg 23460 gtagattgtt aactccaaga taccagtata cctcaaaaat ttgagtgaga tccgctgcca 23520 agttcctatt attgaagatc gcaataccca attctttgac ctgagttagt gatctccaat 23580 ccatgttagc gcttcctaaa taaatatgtg tattatcaga tatccaaaat tttgtatgaa 23640 gaactcctcc taggatattt gtaatatcta tgtatcgtac ttca actccg gccatttgta 23700 gtctttcaac atcctttaat ggtttgttag atttattgac ggctactcta actcgtactc 23760 ctcttttggg taattgtaca atctcgttta atattatcgt gccgaaattc gtacccactt 23820 catccgataa actccaataa aaagatgata tatctagtgt ttttgtggta ttggatagaa 23880 tttccctcca catgttaaat gtagacaaat atactttatc aaattgcata cctataggaa 23940 tagtctctgt aatcactgcg attgtattat ccggattcat tttatttgtt aaaagaataa 24000 tcctatatca cttcactcta ttaaaaatcc aagtttctat ttctttcatg actgattttt 24060 taacttcatc cgtttcctta tgaagatgat gtttggcacc ttcataaatt tttatttctc 24120 tattacaatt tgcatgttgc atgaaataat atgcacctaa aacatcgcta atctcattgt 24180 ttgttccctg gagtatgaga gtcggggtgt taatcttgga aattattttt ctaaccttgt 24240 tggtagcctt caagacctga ctagcaaatc cagccttaat tttttcatga ttgattaatg 24300 ggtcgtattg gtatttataa actttatcca tatctctaga tactgattct ggacatagct 24360 ttccgactgg cgcatttggt gtgatggttc ccataagttt ggcagctagc agattcagtc 24420 ttgaaacagc atctgcatta actagaggag acattagaat cattgctgta aacaagtttg 24480 gattatcgta agaggctagt atagaaattg ttgctcc cat ggaatgaccc aataagtaga 24540 tttaatagtt accacgtgct gtaccaaagt catcaatcat cattttttca ccattacttc 24600 ttccatgtcc aatatgatca tgtgagaata ctaaaattcc taacgatgat atgttttcag 24660 ctagttcgtc ataacgtcca gaatgtttac cagctccatg acttatgaat actaatgcct 24720 taggatatgt aatcattgtc cagattgaac atacagtttg cactcatgat tcacgttata 24780 taactatcaa tattaacagt tcgtttgatg atcatattat ttttatgttt tattgataat 24840 tgtaaaaaca tacaattaaa tcaatataga ggaaggagac ggctactgtc ttttgtgaga 24900 tagtcatggc gactaaatta gattatgagg atgctgtttt ttactttgtg gatgatgata 24960 aaatatgtag tcgcgactcc atcatcgatc taatagatga atatattacg tggagaaatc 25020 atgttatagt gtttaacaaa gatattacca gttgtggaag actgtacaag gaattgatga 25080 agttcgatga tgtcgctata cggtactatg gtattgataa aattaatgag attgtcgaag 25140 ctatgagcga aggagaccac tacatcaatt ttacaaaagt ccatgatcag gaaagtttat 25200 tcgctaccat aggaatatgt gctaaaatca ctgaacattg gggatacaaa aagatttcag 25260 aatctagatt ccaatcattg ggaaacatta cagatctgat gaccgacgat aatataaaca 25320 tcttgatact ttttctagaa aaaaaattga attgatgata taggggtctt cataacgcat 25380 aattattacg ttagcattct atatccgtgt taaaaaaaat tatcctatca tgtatttgag 25440 agttttatat gtagcaaaca tgatagctgt gatgccaata agctttagat attcacgcgt 25500 gctagtgtta gggatggtat tatctggtgg tgaaatgtcc gttatataat ctacaaaaca 25560 atcatcgcat atagtatgcg atagtagagt aaacattttt atagttttta ctggattcat 25620 acatcgtcta cccaattcgg ttatgaatga aattgtcgcc aatcttacac ccaacccctt 25680 gttatccatt agtatagtat taacttcgtt atttatgtca taaactgtaa atgattttgt 25740 agatgccata tcatacatga tattcatgtc cctattataa tcattactaa ctttatcaca 25800 atatatgttg ataatatcta tatatgatct agtctttgtg ggcaactgtc tatacaagtc 25860 gtctaaacgt tgtttactca tatagtatcg aacagccatc attacatggt cccgttccgt 25920 tgatagataa tcgagtatgt tagtggactt gtcaaatcta tataccatat tttctggaag 25980 tggatataca tagtcgtgat caacattatt gctagcctca tcttctatat cctgtactat 26040 accatctaca taatctacga tattattaca cataaacatc gacaacatac tattgtttat 26100 tatctaagtc ctgttgatcc aaacccttga tctcctctat ttgtactatc tagagattgt 26160 acttcttcca gttctggata at atatacgt tgatagatta gctgagctat tctatctcca 26220 gtatttacat taaacgtaca ttttccatta ttaataagaa tgactcctat gtttccccta 26280 taatcttcgt ctattacacc acctcctata tcaatgcctt ttagtgacag accagaccta 26340 ggagctattc taccatagca aatcttaggc atggacatac taatatctgt cttaattaac 26400 tgtctttctc ctggagggat agtataatcg taagcgctat acaaatcata tccggcagca 26460 cccggcgatt gcctagtagg agatttagct ctgttagttt ccttaacaaa tctaactggt 26520 gagttaatat tcatgttgaa cataaaacta atattttatt tcaaaattat ttaccatccc 26580 atatattcca tgaataagtg tgatgattgt acacttctat agtatctata tacgattcac 26640 gataaaatcc tcctatcaat agcagtttat tatccactat gatcaattct ggattatccc 26700 tcggataaat aggatcatct atcagagtcc atgtattgct ggattcacaa taaaattccg 26760 catttctacc aaccaagaat aaccttctac cgaacactaa cgcgcatgat ttataatgag 26820 gataataagt ggatggtcca aactgccact gatcatgatt gggtagcaaa tattctgtag 26880 ttgtatcagt ttcagaatgt cctcccatta cgtatataac attgtttatg gatgccactg 26940 ctggattaca tctaggtttc agaagactcg gcatattaac ccaagcagca tccccgtgga 27000 accaacgctc aacag atgtg ggatttggta gacctcctac tacgtataat ttattgttag 27060 cgggtatccc gctagcatac agtctggggc tattcatcgg aggaattgga atccaattgt 27120 ttgatatata atttacagct atagtacattacgt tatgtattatttt tacctatacgt tatgtattatttc tacctata 27ttcat gatccatgtt cataggatac tctatgaatg gatacttgta tgatttgcgt ggttgtttat 27300 cacaatgaaa tattttggta cagtctagta tccattttac attatttata cctctgggag 27360 aaagataatt tgacctgatt acatttttga taaggagtag cagatttcct aatttatttc 27420 ttcgctttat ataccactta atgacaaaat cctcatctgg aacatttagt tcatcgcttt 27480 ctagaataag tttcatagat agataatcaa aattgtctat gatgtcatct tccagttcca 27540 aaaagtgttt ggcaataaag tttttagtat gacataagag attggatagt ccgtattcta 27600 tacccatcat gtaacactcg acacaatatt cctttctaaa atctcgtagg ataaagttta 27660 tacaagtgta gatgataaat tctacagagg ttaatataga agcacgtaat aaattgacga 27720 cgttatgact atctatatat acctttccag tatatgagta aataactata gaagttagac 27780 tgtgaatgtc aaggtctaga caaaccctcg taactggatc tttatttttc gtgtattttt 27840 gacgtaaatg tgtgcgaaag taaggagata actttttcaa tatcgtagaa ttgactatta 27900 tattgcctcc tatggcatca ataattgttt tgaatttctt agtcatagac aatgctaata 27960 tattcttaca gtacacagta ttgacaaata tcggcattta tgtttcttta aaagtcaaca 28020 tctaaagaaa aatgattatc ttcttgagac ataactccca ttttttggta ttcacccac a 28080 cgtttttcga aaaaattagt tttaccttct aatgatatat tttccatgaa atcaaacgga 28140 ttggtaacat tataaatttt tttaaatccc aattcagaaa tcaatctatc cgcgacgaat 28200 tctatatatg ttttcatcat ttcacaattc attcctataa gtttaactgg aagagccgca 28260 gtaagaaatt cttgttcaat ggataccgca tctgttataa tagatctaac ggtttcttca 28320 ctcggtggat gcaataaatg tttaaacatc aaacatgcga agtcgcagtg tagaccctcg 28380 tctctactaa tcaattcgtt ggaaaacgtg agtccgggca ttaggccacg ctttttaagc 28440 caaaatatgg aagcgaatga tccggaaaag aagattcctt ctactgcagc aaaggcaata 28500 agtctctctc cataaccggc gctgtcatgt atccactttt gagcccaatc ggccttcttt 28560 tttacacaag gcatcgtttc tatggcatta aagagatagt ttttttcatt actatcttta 28620 acataagtat cgatcaaaag actatacatt tccgaatgaa tgttttcaat ggccatctga 28680 aatccgtaga aacatctagc ctcggtaatc tgtacttctg tacaaaatcg ttccgccaaa 28740 ttttcattca ctattccgtc actggctgca aaaaacgcca atacatgttt tataaaatat 28800 ttttcgtctg gtgttagttt attccaatca ttgatatctt tagatatatc tacttcttcc 28860 actgtccaaa atgatgcctc tgccttttta tacatgttcc agatgtcatg a tattggatt 28920 gggaaaataa caaatctatt tggatttggt gcaaggatgg gttccataac taaattaaca 28980 ataacaataa attttttttc agttatctat atgcctgtac ttggatcttt tgtacatcga 29040 tatcgccgca atcactacaa taattacaag tattattgat agcattgtta ttagtactat 29100 cataattaaa ttatcgttat tatcattttg taattgtgac atcatactag ataaatcgtt 29160 tgcgagattg ttgtgggaag cgggcatgga ggatgaatta tcgttattat tatttaaagc 29220 ctcccattcg gattcacaaa tatggcgcgc gttcaacatt ttatggaaac agataacaag 29280 aaaactcgtc atcgttcaaa tttttaacga tagtaaaccg attaaacgtc gagctaattt 29340 ctaacgctag cgactctgtt ggatatgggt ttccagatat atatcttttc agttccccta 29400 cgtatctata atcatctgta ggaaatggaa gatatttcca tttatctact gttcctaata 29460 tcatatgtgg tggtgtagta gaaccattaa gcgcgaaaga tgttatttcg catcgtattt 29520 taacttcgca ataatttctg gttagataac gcactctacc agtcaagtca atgatattag 29580 cctttacaga tatattcata gtagtcgtaa cgatgactcc atcttttaga tgcgatactc 29640 ctttgtatgt accagaatct tcgtacctca aactcgatat atttaaacaa gttaatgaga 29700 tattaacgcg ttttatgaat gatgatatat aaccagaagt ttta tcctcg gtggctagcg 29760 ctataacctt atcattataa taccaactag tgtgattaat atgtgacacg ttagtgtggg 29820 tacaaatatg tacattatcg tctacgtcgt attcgataca tccgcataca gccaacaaat 29880 ataaaatgac aaatactcta acgccgttcg tacccatctt gatgcggttt aataaatgtt 29940 ttgatttcaa tttattgtaa aaaaagattc ggttttatac tgttcgatat tctcattgct 30000 tatattttca tctatcatct ccacacagtc aaatccgtgg ttagcatgca cctcatcaac 30060 cggtaaaaga ctatcggact cttctatcat tataactcta gaatatttaa tttggtcatt 30120 attaatcaag tcaattatct tatttttaac aaacgtgagt attttactca ttttttataa 30180 aaacttttag aaatatacag actctatcgt gtgtctatat cttcttttta tatccaatgt 30240 atttatgtct gatttttctt catttatcat atataatggt ccaaattcta cacgtgcttc 30300 ggattcatcc agatcattaa ggttcttata attgtaacat ccttctcttc cctcttctac 30360 atcttccttc ttattcttat tcttagcgtc acagaatcta ccacagcagg atcccatgac 30420 gagcgtcata ttaaactaat ccattttcaa ttataatata cgattagtaa tgaccattaa 30480 aataaaaata ttcttcataa ccggcaagaa agtgaaaagt tcacattgaa actatgtcag 30540 tagtatacat catgaaatga tgatatatat atactct att ttggtggagg attatatgat 30600 ataattcgtg gataatcatt cttaagacac atttcttcat tcgtaaatct tttcacgtta 30660 aatgagtgtc catattttgc aatttcttca tatgatggcg gtgtacgtgg acgaggctgc 30720 tcctgttctt gttgtagtcg ccgactgtcg tgtctgcgtt tagatccctc cattatcgcg 30780 attgcgtaga tggagtacta ttttatacct tgtaattaaa tttttttatt aattaaacgt 30840 ataaaaacgt tccgtatctg tatttaagag ccagatttcg tctaatagaa caaatagcta 30900 cagtaaaaat aactagaata attgctacac ccactagaaa ccacggatcg taatacggca 30960 atcggttttc gataataggt ggaacgtata ttttatttaa ggacttaaca attgtctgta 31020 aaccacaatt tgcttccgcg gatcctgtat taactatctg taaaagcata tgttgaccgg 31080 gcggagccga acattctccg atatccaatt tctgtatatc tataatatta ttaacctccg 31140 catacgcatt acagttcttt tctagcttgg ataccgcact aggtacatcg tctagatcta 31200 ttcctatttc ctcagcgata gctcttctat ccttttccgg aagcaatgaa atcacttcaa 31260 taaatgattc aaccatgagt gtgaaactaa gtcgagaatt actcatgcat ttgttagtta 31320 ttcggagcgc gcaattttta aactgtccta taacctctcc tatatgaata gcacaagtga 31380 cattagtagg gatagaatgt tgagctaatt tttgtaaata actatctata aaaagattat 31440 acaaagtttt aaactcttta gtttccgcca tttatccagt ctgagaaaat gtctctcata 31500 ataaattttt ccaagaaact aattgggtga agaatggaaa cctttaatct atatttatca 31560 cagtctgttt tggtacacat gatgaattct tccaatgccg tactaaattc gatatctttt 31620 tcgatttctg gatatgtttt taataaagta tgaacaaaga aatggaaatc gtaataccag 31680 ttatgtttaa ctttgaaatt gttttttatt ttcttgttaa tgattccagc cacttgggaa 31740 aagtcaaagt cgtttaatgc cgatttaata cgttcattaa aaacaaactt tttatccttt 31800 agatgaatta ttattggttc attggaatca aaaagtaaga tattatcggg tttaagatct 31860 gcgtgtaaaa agttgtcgca gcatggtagt tcgtaaattt taatgtataa cagagccatc 31920 tgtaaaaaga taaactttat gtattgtacc aaagatttaa atcctaattt gatagctagc 31980 tcggtatcta ctttatctgc cgaatacagt gctaggggaa aaattataat atttcctctt 32040 tcgtattcgt agttagttct cttttcatgt tcgaaaaagt gaaacatgcg gttaaaatag 32100 tttataacat taatattact gttaataact gccggataaa agtgggatag taatttcacg 32160 aatttgatac tgtcctttct ctcgttaaac gcctttaaaa aaactttaga agaatatctc 32220 aatgatagtt cctgaccatc ca tagtttgt atcaataata gcaacatatg aagaacacgt 32280 ttatacagag tatgtaaaaa tgttaattta tagtttaatc ccatggccca cgcacacacg 32340 attaattttt tttcatctcc ctttagattg ttgtatagaa atttgggtac tgtgaactcc 32400 gccgtagttt ccatgggact atataatttt gtggcctcga atacaaattt tactacatag 32460 ttatctatct taaagactat accatatcct cctgtagata tgtgataaaa atcgtcgttt 32520 ataggataaa atcgtttatc cttttgttgg aaaaaggatg aattaatgta atcattctct 32580 tctatcttta gtagtgtttc cttattaaaa ttcttaaaat aatttaacaa tctaactgat 32640 ggagcccaat tttggtgtaa atctaattgg gacattatat tgttaaaata caaacagtct 32700 cctaatataa cagtatctga taatctatgg ggagacatcc attgatattc aggggatgaa 32760 tcattggcaa cacccattta ttgtacaaaa agccccaatt tacaaacgaa agtccaggtt 32820 tgatagagac aaactattaa ctattttgtc tctgttttta atttctttgg taatgaaatt 32880 attcacaata tcagtatctt ctttatctac cagagatttt actaacttga taaccttggc 32940 tgtctcattc aatagggtag taatatttgt atgtgtgata ttgatatctt ttagaagtga 33000 ttctttgatg gtgccagcat acgaattaca ataatgcaga aactcggtta acatgcagga 33060 attatagtaa gccaa ttcca attgttgcct gtgttgtatt agagtgtcaa tatgagcaat 33120 ggtgtccttg cgtttctctg atagaatgcg agcagcgatt ttggcgttat catttgacga 33180 tatttctgga atgacgaatc ctgtttctac taactttttg gtaggacaaa gtgaaacaat 33240 caagaagata gcttctcctc ctatttgtgg aagaaattga actcctctag atgatctcct 33300 tgacagatat tggaccgaat tacagaagta cctggaatgt aaagccctga aaccccctca 33360 ttttttaagc agattgttgc cgtaaatcct gcactatgcc caagatagag agctcctttg 33420 gtgaatccat ctctatgttt cagtttaacc aagaaacagt cagctggtct aaaatttcca 33480 tctctatcta atacagcatc taacttgatg tcaggaacta tgaccggtta tgttatatgt 33540 aacattgagt aaatccttaa gttcataatc atcactgtca tcagttatgt acgatccaaa 33600 caatgtttct actggcatag tggatacgaa gatgctatcc atcagaatgt ttccctgatt 33660 agtattttct atatagctat tcttctttaa acgattttcc aaatcagtaa ctatgttcat 33720 ttttttagga gtaggacgcc tagccagtat ggaagaggat tttctagatc ctctcttcaa 33780 catctttgat ctcaatggaa tgcaaaaccc catagtgtaa caaccaacga taaaaataat 33840 attgtttttc actttttata attttaccat ctgactcatg gattcattaa tatctttata 33900 agagctac ta acgtataatt ctttataact gaactgagat atatacaccg gatctatggt 33960 ttccataatt gagtaaatga atgctcggca ataactaatg gcaaatgtat aaaacaacga 34020 aattatacta gagttgttaa agttaatatt ttctatgagc tgttccaata aattatttgt 34080 tgtaactgcg ttcaagtcat aaatcatctt gatactatcc agtaaaccgt ttttaagttc 34140 tggaatatta ttatcccatt gtaaagcccc taattcgact atcgaatatc ctgctctgat 34200 agcagtttca atatcgacgg acgtcaatac tgtaataaag gtggtagtat tgtcatcatc 34260 gtgataaact actggaatat ggtcgttagt aggtacggta actttacaca acgcgatata 34320 taactttcct tttgtaccat ttttaacgta gttgggacgt cctgcagggt attgttttga 34380 agaaatgata tcgagaacag atttgatacg atatttgttg gattcctgat tatttactat 34440 aatataatct agacagatag atgattcgat aaatagagaa ggtatatcgt tggtaggata 34500 atacatcccc attccagtat tctcggatac tctattaatg acactagtta agaacatgtc 34560 ttctattcta gaaaacgaaa acatcctaca tggactcatt aaaacttcta acgctcctga 34620 ttgtgtctcg aatgcctcgt acaaggattt caaggatgcc atagattctt tgaccaacga 34680 tttagaattg cgtttagcat ctgatttttt tattaaatcg aatggtcggc tctctggttt 34740 gctaccccaa tgataacaat agtcttgtaa agataaaccg caagaaaatt tatacgcatc 34800 catccaaata accctagcac catcggatga tattaatgta ttattataga ttttccatcc 34860 acagttattg ggccagtata ctgttagcaa cggtatatcg aatagattac tcatgtaacc 34920 tactagaatg atagttcgtg tactagtcat aatatcttta atccaatcta agaaatttaa 34980 aattagattt tttacactgt taaagttaac aaaggtatta cccggatacg tggatatcat 35040 atatggtatt ggtccattat cagtaatagc tccataaact gatacggcga tggtttttat 35100 atgtgtttga tctaacgagg aagaaattcg cgcccacaat tcatctctag atatgtattt 35160 aatatcaaac ggtaacacat caatttcggg acgcgtatat gtttctaaat ttttaatcca 35220 aatataatga tgacctatat gccctattat catactgtca actatagtac acctagagaa 35280 cttacgatac atctgtttcc tataatcgtt aaattttaca aatctataac atgctaaacc 35340 ttttgacgac aaccattcat taatttctga tatggaatct gtattctcaa taccgtatcg 35400 ttctaaagcc agtgctatat ctccctgttc gtgagaacgc tttcgtataa tatcgatcaa 35460 cggataatct gaagtttttg gagaataata tgactcatga tctatttcgt ccataaacaa 35520 tctagacata ggaattggag gcgatgatct taattttgtg caatgagtcg tcaatccta t 35580 aacttctaat attgtaatat tcatcatcga cataacacta tctatgttat catcgtatat 35640 tagtatacca tgaccttctt catttcgtgc caaaatgata tacagtctta aatagttacg 35700 caatatctca atagtttcat aattgttagc tgttttcatc aaggtttgta tcctgtttaa 35760 catgatggcg ttctatacgt ttctattttt taaattttta acgatttact gtggctagat 35820 acccaatctc tctcaaatat ttttttagcc tcgcttacaa gctgtttatc tatactatta 35880 aaactgacga atccgtgatt ttggtaatgg gttccgtcga aatttgccga agtgatatga 35940 acatattcgt cgtcgactat caacaatttt gtattattct gaatagtgaa aaccttcaca 36000 gatagatcat tttgaacaca caacgcgtct agacttctgg cggttgccat agaatatacg 36060 tcgttcttat cccaattacc aactagaagt ctgatcttaa ctcctctatt aatggctgct 36120 tctataatgg agttgtaaat gtcgggccaa tagtagctat taccgtcgac acgtgtagtg 36180 ggaactatgg ccaaatgttc aatatctata ctagtcttag ccgacttgag tttatcaata 36240 actacatcag tgtctagatc tctagaatat cccaataggt gttccggaga atcagtaaag 36300 aacactccac ctataggatt cttaatatga tacgcagtgc taactggcag acaacaagcc 36360 gcagagcata aattcaacca tgaatttttt gcgctattaa aggctttaaa a gtatcaaat 36420 cttctacgaa gatctgtggc cagcggggga taatcagaat atacacctaa cgttttaatc 36480 gtatgtatag atcctccagt aaatgacgcg tttcctacat aacatctttc attatctgac 36540 acccaaaaac aaccgagtag tagtcccaca ttattttttt tatctatatt aacggttata 36600 aaatttatat ccgggcagtg actttgtagc tctcccagat ttcttttccc tcgttcatct 36660 agcaaaacta ttattttaat ccctttttca gatgcctctt ttagtttatc aaaaataagc 36720 gctcccctag tcgtactcag aggattacaa caaaaagatg ctatgtatat atatttctta 36780 gctagagtga taatttcgtt aaaacattca aatgttgtta aatgatcgga tctaaaatcc 36840 atattttctg gtagtgtttc taccagccta cattttgctc ccgcaggtac cggtgcaaat 36900 ggccacattt agttaacata aaaacttata catcctgttc tatcaacgat tctagaatat 36960 catcggctat atcgctaaaa ttttcatcaa agtcgacatc acaacctaac tcagtcaata 37020 tattaagaag ttccatgatg tcatcttcgt ctatttctat atccgtatcc attgtagatt 37080 gttgaccgat tatcgagttt aaatcattac taatactcaa tccttcagaa tacaatctgt 37140 gtttcattgt aaatttatag gcggtgtatt taagttggta gattttcaat tatgtatcaa 37200 tatagcaaca gtagttcttg ctcctccttg attctagcat cctc ttcatt attttcttct 37260 acgtacataa acatgtccaa tacgttagac aacacaccga cgatggcggc cgccacagac 37320 acgaatatga ctaaaccgat gaccatttaa aaacccctct ctagctttca cttaaactgt 37380 atcgattatt cttttagaac atgtataata taaaaacatt attctatttc gaatttaggc 37440 ttccaaaaat ttttcatccg taaaccgata ataatatata tagacttgtt aatagtcgga 37500 ataaatagat taatgcttaa actatcatca tctccacgat tagagataca atatttacat 37560 tttttttgct gtttcgaaac tttatcaata cacgttaata caaacccagg aaggagatat 37620 tgaaactgag gctgttgaaa atgaaacggt gaatacaata attcagataa tgtaaaatca 37680 tgattccgta ttctgatgat attagaactg ctaatggatg tcgatggtat gtatctagga 37740 gtatctattt taacaaagca tcgatttgct aatatacaat tatcattttg attaattgtt 37800 attttattca tattcttaaa aggtttcata tttatcaatt cttctacatt aaaaatttcc 37860 atttttaatt tatgtagccc cgcaatactc ctcattacgt ttcatttttt gtctataata 37920 tccattttgt tcatctcggt acatagatta tccaattgag aagcgcattt agtagttttg 37980 tacattttaa gtttattgac gaatcgtcga aaactagtta tagttaacat tttattattt 38040 gataccctga tattaatacc cctgccgtta ctattat tta taactgatgt aatccacgta 38100 acattggaat taactatcga tagtaatgca tcgacgcttc caaaattgtc tattataaac 38160 tcaccgataa tttttttatt acatgttttc atattcatta ggattattaa atctttaatc 38220 ttactacgat tgtatgcgtt gatattgcaa gacgtcattc taaaagacgg aggatctcca 38280 tcaaatgcca gacaatcacg tacaaagtac atggaaatag gttttgttct attgcgcatc 38340 atagatttat atagaacacc cgtagaaata ctaatttgtt ttactctata aaatactaat 38400 gcatctattt catcgttttg tataacgtct ttccaagtgt caaattccaa atttttttca 38460 ttgatagtac caaattcttc tatctcttta actacttgca tagataggta attacagtga 38520 tgcctacatg ccgttttttg aaactgaata gatgcgtcta gaagcgatgc tacgctagtc 38580 acaatcacca ctttcatatt tagaatatat atatgtaaaa atatagtaga atttcatttt 38640 gttttttttc tatgctataa atgaattctc attttgcatc tgctcatact ccgttttata 38700 tcaataccaa agaaggaaga tatctggttc taaaagccgt taaagtatgc gatgttagaa 38760 ctgtagaatg cgaaggaagt aaagcttcct gcgtactcaa agtagataaa ccctcatcac 38820 ccgcgtgtga gagaagacct tcgtcccctt ccagatgcga gagaatgaat aacccaggaa 38880 aacaagttcc gtttatgagg acggacatgc tacaaaatat gttcgcggct aatcgcgata 38940 atgtagcttc tagacttttg tcctaaaata caattatatc cttttcgata ttaataaatc 39000 cgtgtcgtcc aggtttttta tctctttcag tatgtgaata gataggtatt ttatctctat 39060 tcatcatcga atttaagaga tccgataaac attgtttgta ttctccagat gtcagcatct 39120 gatacaacaa tatatgtgca cataaacctc tggcacttat ttcatgtacc ttccccttat 39180 cactaaggag aatagtattt gagaaatatg tatacatgat attatcatga attagatata 39240 cagaatttgt aacactctcg aaatcacacg atgtgtcggc gttaagatct aatatatcac 39300 tcgataacac attttcatct agatacacta gacatttttt aaagctaaaa tagtctttag 39360 tagtaacagt aactatgcga ttattttcat cgatgataca tttcatcggc atattattac 39420 gcttaccatc aaagactata ccatgtgtat atctaacgta ttctagcatg gttgccatac 39480 gcgcattaaa cttttcagga tctttggata gatcttccaa tctatctatt tgagaaaaca 39540 tttttatcat gttcaatagt tgaaacgtcg gatccactat atagatatta tctataaaga 39600 ttttaggaac tacgttcatg gtatcctggc gaatattaaa actatcaatg atatgattat 39660 cgttttcatc ttttatcacc atatagtttc taagatatgg gattttactt aatataatat 39720 tatttcccgt aataaatttt at tagaaatg ccaaatctat aagaaaagtc ctcgaattag 39780 tttgaagaat atctatatcg ccgtaccgta tatttggatt aattagatat agagaatatg 39840 atccgtaaca tatacaactt ttattatggc gtctaagata ttcttccatc aacttattaa 39900 catttttgac tagggaagat acattatgac gtcccattac ttttgccttg tctattactg 39960 cgacgttcat agaatttagc atatctcttg ccaattcttc cattgatgtt acattataag 40020 aaattttaga tgaaattaca tttggagctt taatagtaag aactcctaat atgtccgtgt 40080 atgtggtcac taatacagat tgtagttcta taatcgtaaa taatttacct atattatatg 40140 tttgagtctg tttagaaaag tagctaagta tacgatcttt tatttctgat gcagatgtat 40200 caacatcgga aaaaaatctt tttttattct tttttactaa agatacaaat atgtctttgt 40260 taaaaacagt tattttctga atatttctag cttgtaattt taacatatga tattcgttca 40320 cactaggtac tctgcctaaa taggtttcta taatctttaa tgtaatatta ggaaaagtat 40380 tctgatcagg attcctattc attttgagga tttaaaactc tgattattgt ctaatatggt 40440 ctcaacacaa actttttcac agagcgatag agtttttgat aactcgtttt tcttaagaaa 40500 tataaaacta ctgtctccag agctcgctct atcttttatt ttatttaatt cgatacaaac 40560 tcctgatact ggttc agaaa gtaattcatt aattttcagt cctttataga agatatttaa 40620 tatagataat acaaaatctt cagtttttga tatcgatctg attgatccta gaactagata 40680 tattaataac gtgctgctcatta ggcagtttat gatatta tagattt 740 tatttagtata tattga tatta aaataaatcc aaaataacta gacattctat tttttgtgga ttagtgtact ctcttccctc 40860 tatcatgttc actactggtg tccacgatga taaatatcta gagggaatat aatatagtcc 40920 ataggatgcc aatctagcaa tgtcgaataa ctgtaatttt attcttcgct cttcattatg 40980 aattgattct tgaggtataa acctaacaca aattatatta ttagactttt cgtatgtaat 41040 gtctttcatg ttataagttt ttaatcctgg aatagaatct attttaatga ggcttttaaa 41100 cgcagagttc tccaacgagt caaagcataa tactctgttg gttttcttat atacgatgtt 41160 acgattttct tctttgaatg gaataggttt ttgaattagt ttataattac aacataatag 41220 ataaggaagt gtgcaaatag tacgcggaaa aaacataata gctcccctgt tttcatccat 41280 ggttttaagt aaatgatcac tggcttcttt agtcaatgga tattcgaaca ttaaccgttt 41340 catcatcatt ggacagaatc catatttctt aatgtaaaga gtgatcaaat cattgtgttt 41400 attgtaccat cttgttgtaa atgtgtattc ggttatcgga tctgctcctt tttctattaa 41460 agtatcgatg tcgatctcgt ctaagaattc aactatatcg acatatttca tttgtataca 41520 cataaccatt actaacgtag aatgtatagg aagagatgta acgggaacag ggtttgttga 41580 ttcgcaaact attctaatac ataattcttc tgttaatacg tcttgcacgt aatctatta t 41640 agatgccaag atatctatat aattattttg taagatgatg ttaactatgt gatctatata 41700 agtagtgtaa taattcatgt atttcgatat atgttccaac tctgtctttg tgatgtctag 41760 tttcgtaata tctatagcat cctcaaaaaa tatattcgca tatattccca agtcttcagt 41820 tctatcttct aaaaaatctt caacgtatgg aatataataa tctattttac ctcttctgat 41880 atcattaatg atatagtttt tgacactatc ttctgtcaat tgattcttat tcactatatc 41940 taagaaacgg atagcgtccc taggacgaac tactgccatt aatatctcta ttatagcttc 42000 tggacataat tcatctatta taccagaatt aatgggaact attccgtatc tatctaacat 42060 agttttaaga aagtcagaat ctaagacctg atgttcatat attggttcat acatgaaatg 42120 atctctattg atgatagtga ctatttcatt ctctgaaaat tggtaactca ttctatatat 42180 gctttccttg ttgatgaagg atagaatata ctcaatagaa tttgtaccaa caaactgttc 42240 tcttatgaat cgtatatcat catctgaaat aatcatgtaa ggcatacatt taacaattag 42300 agacttgtct cctgttatca atatactatt cttgtgataa tttatgtgtg aggcaaattt 42360 gtccacgttc tttaattttg ttatagtaga tatcaaatcc aatggagcta cagttcttgg 42420 cttaaacaga tatagttttt ctggaacgaa ttctacaaca ttattataaa g gactttggg 42480 tagataagtg ggatgaaatc ctattttaat taatgcgata gccttgtcct cgtgcagata 42540 tccaaacgct tttgtgatag tatggcattc attgtctaga aacgctctac gaatatctgt 42600 gacagatatc atctttagag aatatactag tcgcgttaat agtactacaa tttgtatttt 42660 ttaatctatc tcaataaaaa aattaatatg tatgattcaa tgtataacta aactactaac 42720 tgttattgat aactagaatc agaatctaat gatgacgtaa ccaagaagtt tatctactgc 42780 caatttagct gcattatttt tagcatctcg tttagatttt ccatctgcct tatcgaatac 42840 tcttccgtcg atatctacac aggcataaaa tgtaggagag ttactaggcc ccactgattc 42900 aatacgaaaa gaccaatctc tcttagttat ttggcagtac tcattaataa tggtgacagg 42960 gttagcatct ttccaatcaa taattttttt agccggaata acatcatcaa aagacttatg 43020 atcctctctc attgattttt cgcgggatac atcatctatt atggcgtcag ccataacatc 43080 agcatccggc ttatccgcct ccgttgtcat aaaccaacga ggaggaatat cgtcggagct 43140 gtacaccata gcactacgtt gaagatcgta cagagcttta ttaacttctc gcttctccat 43200 attaagttgt ctagttagtt gtgcagcagt agctccttcg attccaatgt ttttaatagc 43260 cgcacacaca atctctgcgt cagaacgctc gtcaatatag atct tagaca tttttagaga 43320 gaactaacac aaccagcaat aaaactaatt tattttatca tttttttatt catcatcctc 43380 tggtggttcg tcgtttctat cgaatgtgga tctgattaac ccgtcatcta taggtgatgc 43440 tggttctgga gattctggag gagatggatt attatctgga agaatctctg ttatttcctt 43500 gttttcatgt atcgattgcg ttgtaacatt aagattgcga aatgctctaa atttgggagg 43560 cttaaagtgt tgtttgcaat ctctacacgc atgtctaact agtggaggtt cgtcagcggc 43620 tctagtttga atcatcatcg gcgtagtatt cctactttta cagttaggac acggtgtatt 43680 gtatttctcg tcgagaacgt taaaataatc gttgtaactc acatccttta ttttatctat 43740 attgtattct actcctttct taatgcattt tataccgaat aagagatagc gaaggaattc 43800 tttttcggtg ccgctagtac ccttaatcat atcacatagt gttttatatt ccaaatttgt 43860 ggcaatagac ggtttatttc tatacgatag tttgtttctg gaatcctttg agtattctat 43920 accaatatta ttctttgatt cgaatttagt ttcttcgata ttagattttg tattacctat 43980 attcttgatg tagtactttg atgatttttc catggcccat tctattaagt cttccaagtt 44040 ggcatcatcc acatattgtg atagtaattc tcggatatca gtagcggcta ccgccattga 44100 tgtttgttca ttggatgagt aactactaat gtataca ttt tccatttata acacttatgt 44160 attaactttg ttcatttata ttttttcatt attatgttga tattaacaaa agtgaatata 44220 tatgttaata attgtattgt ggttatacgg ctacaatttc ataatgagtg gaagtcagtg 44280 tccgatgatc aatgacgata gctttactct gaaaagaaag tatcaaatcg atagtgcgga 44340 gtcaacaata aaaatggata agaagaggat aaagtttcag aatagagcca aaatggtaaa 44400 agaaataaat cagacaataa gagcagcaca aactcattac gagacattga aactaggata 44460 cataaaattt aagagaatga ttaggactac tactctagaa gatatagcac catctattcc 44520 aaataatcag aaaacttata aactattctc ggacatttca gccatcggca aagcatcaca 44580 gaatccgagt aagatggtat atgctctgct gctttacatg tttcccaatt tgtttggaga 44640 tgatcataga ttcattcgtt atagaatgca tccaatgagt aaaatcaaac acaagatctt 44700 ctctcctttc aaacttaatc ttattagaat attagtggaa gaaagattct ataataatga 44760 atgcagatct aataaatgga gaataattgg aacacaagtt gataaaatgt tgatagctga 44820 atctgataaa tatacaatag atgcaaggta taacctaaaa cccatgtata gaatcaaggg 44880 aaaatctgaa gaagataccc tctttatcaa acagatggta gaacaatgtg tgacatccca 44940 ggaattggtg gaaaaagtgt tgaagatact gtttagagat ttgttcaaga gtggagaata 45000 caaagcgtac agatacgatg atgatgtaga aaatggattt attggattgg atacactaaa 45060 attaaacatt gttcatgata tagttgaacc atgtatgcct gttcgtaggc cagtggctaa 45120 gatactgtgt aaagaaatgg taaataaata ctttgagaat ccgctacata ttattggtaa 45180 aaatcttcaa gagtgcattg actttgttag tgaataggca tttcatcttt ctccaatact 45240 aattcaaatt gttaaattaa taatggatag tataaatagt tattagtgat aaaatagtaa 45300 aaataattat tagaataaga gtgtagtatc atagataact ctcttctata aaaatggatt 45360 ttattcgtag aaagtatctt atatacacag tagaaaataa tatagatttt ttaaaggatg 45420 atacattaag taaagtaaac aattttaccc tcaatcatgt actagctctc aagtatctag 45480 ttagcaattt tcctcaacac gttattacta aggatgtatt agctaatacc aatttttttg 45540 ttttcataca tatggtacga tgttgtaaag tgtacgaagc ggttttacga cacgcatttg 45600 atgcacccac gttgtacgtt aaagcattga ctaagaatta tttatcgttt agtaacgcaa 45660 tacaatcgta caaggaaacc gtgcataaac taacacaaga tgaaaaattt ttagaggttg 45720 ccgaatacat ggacgaatta ggagaactta taggcgtaaa ttatgactta gttcttaatc 45780 cattatttca cggaggggaa cc catcaaag atatggaaat cattttttta aaactgttta 45840 agaaaacaga cttcaaagtt gttaaaaaat taagtgttat aagattactt atttgggctt 45900 acctaagcaa gaaagataca ggcatagagt ttgcggataa tgatagacaa gatatataca 45960 ctctatttca acaaactggt agaatagtcc atagcaatct aacagaaacg tttagagatt 46020 atatctttcc cggagataag actagctatt gggtgtggtt aaacgaaagt atagctaatg 46080 atgcggatat tgttcttaat agacacgcca ttaccatgta tgataaaatt cttagttata 46140 tatactctga gataaaacaa ggacgcgtta ataaaaacat gcttaagtta gtttatatct 46200 ttgagcctga aaaagatatc agagaacttc tgctagaaat catatatgat attcctggag 46260 atatcctatc tattattgat gcaaaaaacg acgattggaa aaaatatttt attagttttt 46320 ataaagctaa ttttattaac ggtaatacat ttattagtga tagaacgttt aacgaggact 46380 tattcagagt tgttgttcaa atagatcccg aatatttcga taatgaacga attatgtctt 46440 tattctctac gagtgctgcg gacattaaac gatttgatga gttagatatt aataacagtt 46500 atatatctaa tataatttat gaggtgaacg atatcacatt agatacaatg gatgatatga 46560 agaagtgtca aatctttaac gaggatacgt cgtattatgt taaggaatac aatacatacc 46620 tgtttttgca cgagt cggat cccatggtca tagagaacgg aatactaaag aaactgtcat 46680 ctataaaatc caagagtaga cggctgaact tgtttagcaa aaacatttta aaatattatt 46740 tagacggaca attggctcgt ctaggtcttg tgttagatga ttataaagga gacttgttag 46800 ttaaaatgat aaaccatctt aagtctgtgg aggatgtatc cgcattcgtt cgattttcta 46860 cagataaaaa ccctagtatt cttccatcgc taatcaaaac tattttagct agttataata 46920 tttccatcat cgtcttattt caaaggtttt tgagagataa tctatatcat gtagaagaat 46980 tcttggataa aagcatccat ctaaccaaga cggataagaa atatatactt caattgataa 47040 gacacggtag atcatagaac agaccaaata tattattaat aatttgtata tacatagata 47100 taattatcac acatttttga taaatgggaa ctgctgcaac aattcagact cccaccaaat 47160 taatgaataa agaaaatgca gaaatgattt tggaaaaaat tgttgatcat atagttatgt 47220 atattagtga cgaatcaagt gattcagaaa ataatcctga atatattgat tttcgtaaca 47280 gatacgaaga ctatagatct ctcattataa aaagtgatca cgagtttgta aagctatgta 47340 aaaatcatgc agagaaaagt tctccagaaa cgcaacaaat gattatcaaa cacatatacg 47400 aacaatatct tattccagta tctgaagtac tattaaaacc tataatgtcc atgggtgaca 47460 taattaca ta taacggatgt aaagacaatg aatggatgct agaacaactc tctaccctaa 47520 actttaacaa tctccgcaca tggaactcat gtagcatagg caatgtaacg cgtctgtttt 47580 atacattttt tagttatctg atgaaagata aactaaatat ataagtataa tcccattcta 47640 atactttaac ctgatgtatt acctgcatct tattagaata ttaacctaac taaaagacat 47700 aacatagttg ataaaaagcg gtaggatata aatattatgg ctgccaccgt tccgcgtttt 47760 gacgacgtgt acaaaaatgc acaaagaaga attctagatc aagaaacatt ttttagtaga 47820 ggtctaagta gaccgttaat gaaaaacaca tatctatttg ataattacgc gtatggatgg 47880 ataccagaaa ctgcaatttg gagtagtaga tacgcaaact tagatgcaag tgactattat 47940 cccatttcgt tgggattact taaaaagttc gagtttctca tgtctctata taaaggtcct 48000 attcccgtat atgaagaaaa agtaaatact gaattcattg ctaatggatc gttctctggt 48060 agatacgtat catatcttcg aaagttttct gcccttccaa caaacgagtt tattagtttt 48120 ttgttactga cttccattcc aatctataat atcttgttct ggtttaaaaa tactcagttt 48180 gatattacta aacacacatt attcagatac gtctatacag ataatgccaa acacctggcg 48240 ttggctaggt atatgcatca aacaggagac tataagcctt tgtttagtcg tctcaaagag 48300 aattatatat ttaccggtcc cgttccaata agtatcaaag atatagatca ccctaatctt 48360 agtagagcaa gaagtccatc cgattatgag acattagcta atattagtac tatattgtac 48420 tttaccaagt atgatccggt attaatgttt ttattgtttt acgtacctgg gtattcaatt 48480 actacaaaaa ttactccagc cgtagaatat ctaatggata aactgaatct aacaaagagc 48540 gacgtacaac tgttgtaaat tattttatgc ttcgtaaaat gtaggttttg aaccaaacat 48600 tctttcaaag aatgagatgc ataaaacttt attatccaat agattgacta tttcggacgt 48660 caatcgttta aagtaaactt cgtaaaatat tctttgatca ctgccgagtt taaaacttct 48720 atcgataatt gtttcatatg ttttaatatt tacaagtttt ttggtccatg gtacattagc 48780 cggacaaata tatgcaaaat aatatcgttc tccaagttct atagtttctg gattattttt 48840 attatattca gtaaccaaat acatattagg gttatctgcg gatttataat ttgagtgatg 48900 cattcgactc aacataaata attctagagg agacgatcta ctatcaaatt cggatcgtaa 48960 atctgtttct aaagaacgga gaatatctat acatacctga ttagaattca tccgtccttc 49020 agacaacatc tcagacagtc tggtcttgta tgtcttaatc atattcttat gaaacttgga 49080 aacatctctt ctagtttcac tagtaccttt attaattctc tcaggtacag attttgaat t 49140 cgacgatgct gagtatttca tcgttgtata tttcttcttc gattgcataa tcagattctt 49200 atataccgcc tcaaactcta ttttaaaatt attaaacaat actctattat taatcagtcg 49260 ttctaactct ttcgctattt ctatagactt atcgacatct tgactgtcta tctctgtaaa 49320 cacggagtcg gtatctccat acacgctacg aaaacgaaat ctgtaatcta taggcaacga 49380 tgttttcaca atcggattaa tatctctatc gtccatataa aatggattac ttaatggatt 49440 ggcaaaccgt aacataccgt tagataactc tgctccattt agtaccgatt ctagatacaa 49500 gatcattcta cgtcctatgg atgtgcaact cttagccgaa gcgtatgagt atagagcact 49560 atttctaaat cccatcagac catatactga gttggctact atcttgtacg tatattgcat 49620 ggaatcatag atggcctttt cagttgaact ggtagcctgt tttagcatct ttttatatct 49680 ggctctctct gccaaaaatg ttcttaatag tctaggaatg gttccttcta tcgatctatc 49740 gaaaattgct atttcagaga tgaggttcgg tagtctaggt tcacaatgaa ccgtaatata 49800 tctaggaggt ggatatttct gaagcaagag ctgattattt atttcttctt ccaatctatt 49860 ggtactaaca acgacaccga ctaatgtttc cggagataga tttccaaaga tacacacatt 49920 aggatacaga ctgttataat caaagattaa tacattatta ctaaacattt t ttgttttgg 49980 agcaaatacc ttaccgcctt cataaggaaa cttttgtttt gtttctgatc taactaagat 50040 agttttagtt tccaacaata gctttaacag tggacccttg atgactgtac tcgctctata 50100 ttcgaatacc atggattgag gaagcacata tgttgacgca cccgcgtctg tttttgtttc 50160 tactccataa tactcccaca aatactgaca caaacaagca tcatgaatac agtatctagc 50220 catatctaaa gctatgttta gattataatc cttatacatc tgagctaaat caacgtcatc 50280 ctttccgaaa gataatttat atgtatcatt aggtaaagta ggacatgata gtacgacttt 50340 aaatccattt tcccaaatat ctttacgaat tactttacat ataatatcct catcaacagt 50400 cacataatta cctgtggtta aaacctttgc aaatgcagcg gctttgcctt tcgcgtccgt 50460 agtatcgtca ccgatgaacg tcatttctct aactcctcta tttaatactt tacccatgca 50520 actgaacgcg ttcttggata tagaatccaa tttgtacgaa tccaattttt cagatttttg 50580 aatgaatgaa tatagatcga aaaatatagt tccattattg ttattaacgt gaaacgtagt 50640 attggccatg ccgcctactc ccttatgact agactgattt ctctcataaa tacagagatg 50700 tacagcttcc tttttgtccg gagatctaaa gataatcttc tctcctgtta ataactctag 50760 acgattagta atatatctca gatcaaagtt atgtccgtta aagg taacga cgtagtcgaa 50820 cgttagttcc aacaattgtt tagctattcg taacaaaact atttcagaac atagaactag 50880 ttctcgttcg taatccattt ccattagtga ctgtatcctc aaacatcctc tatcgacggc 50940 ttcttgtatt tcctgttccg ttaacatctc ttcattaatg agcgtaaaca ataatcgttt 51000 accacttaaa tcgatataac agtaacttgt atgcgagatt gggttaataa atacagaagg 51060 aaacttctta tcgaagtgac actctatatc tagaaataag tacgatcttg ggatatcgaa 51120 tctaggtatt tttttagcga aacagttacg tggatcgtca caatgataac atccattgtt 51180 aatctttgtc aaatattgct cgtccaacga gtaacatccg tctggagata tcccgttaga 51240 aatataaaac caactaatat tgagaaattc atccatggtg gcattttgta tgctgcgttt 51300 ctttggctct tctatcaacc acatatctgc gacggagcat tttctatctt taatatctag 51360 attataactt attgtctcgt caatgtctat agttctcatc tttcccaacg gcctcgcatt 51420 aaatggagga ggagacaatg actgatatat ttcgtccgta actacgtaat aaaagtaatg 51480 aggaaatcgt ataaatacgg tctcgccatt tcgacatctg gatttcagat ataaaaatct 51540 gttttcaccg tgactttcaa accaattaat gcaccgaaca tccatttata gaatttagaa 51600 atatattttc atttaaatga atcccaaaca ttgggga aga gccgtatgga ccattatttt 51660 tatagtactt tcgcaagcgg gtttagacgg caacatagaa gcgtgtaaac gaaaactata 51720 tactatagtc agcactcttc catgtcctgc atgtagacgg cacgcgacta tcgctataga 51780 ggacaataat gtcatgtcta gcgatgatct gaattatatt tattattttt tcatcagatt 51840 atttaacaat ttggcatctg atcccaaata cgcgatcgat gtgacaaagg ttaacccttt 51900 ataaacttaa cccattataa aacttatgat tagtcacgac tgaaataacc gcgtgattat 51960 tttttggtat aattctacac ggcatggttt ctgtaactat gaattcaacc cccgttacat 52020 tagtgaaatc tttaacaaac agcaagggtt cgtcaaagac ataaaactca ttgtttacaa 52080 tcgaaataga ccccctatca cacttaaaat aaaaaatatc cttatccttt accaccaaat 52140 aaaattctga ttggtcaatg tgaatgtatt cacttaacag ttccacaaat ttatttatta 52200 actccgaggc acatacatcg tcggtatttt ttatggcaaa ctttactctt ccagcatccg 52260 tttctaaaaa aatattaacg agttccattt atatcatcca atattattga aatgacgttg 52320 atggacagat gatacaaata agaaggtacg gtacctttgt ccaccatctc ctccaattca 52380 tgctctattt tgtcattaac tttaatgtat gaaaacagta cgccacatgc ttccatgaca 52440 gtgtgtaaca ctttggatac aaaatgtttg acattagtat aattgtccaa gactgtcaat 52500 ctataataga tagtagctat aatatattct atgatggtat tgaagaagat gacaatcttg 52560 gcatattgat catttaacac agacatggta tcaacagata gcttgaatga aagagaatca 52620 gtaattggaa taagcgtctt ctcgatagag tgtccgtata ccaacatgtc tgatattttg 52680 atgtattcca ttaaattatt tagttttttc tttttattct cgttaaacag catttctgtc 52740 aacggacccc aacatcgttg accgattaag ttttgattga tttttccgtg taaggcgtat 52800 ctagtcagat cgtatagcct atccaataat ccatcatctg tgcgtagatc acatcgtaca 52860 ctttttaatt ctctatagaa gagcgacaga cagcaatttc tttattctct acagatgtaa 52920 gatacttgaa gacattccta tgatgatgca gaattttgga taacacggta ttgatggtat 52980 ctgttaccat aattcctttg atggctgata gtgtcagagc acaagatttc caatctttgt 53040 tttgatatct atatcagaca gcatggtgcg tctgacaaca caaggattaa gacggaaaga 53100 tgaaatgatt ctctcaacat cttcaatgga taccttgcta ttttttctgg cattatctat 53160 atgtgcgaga atatcctcta gagaatcagt atcctttttg atgatagtgg atctcaatga 53220 catgggacgt ctaaaccttc ttattctatc accagattgc atggtgattt gtcttctttc 53280 ttttatcata atgtaatctc ta aattcatc ggcaaattgt ctatatctaa aatcataata 53340 tgagatgttt acctctacaa atatctgttc gtccaatgtt agagtatcta catcagtttt 53400 gtattccaaa ttaaacatgg caacggattt aattttatat tcctctatta agtcctcgtc 53460 gataataaca gaatgtagat aatcatttaa tccatcgtac atggttggaa gatgcttgtt 53520 gacaaaatct ttaattgtct tgatgaaggt gggactatat ctaacatctt gattaataaa 53580 atttataaca ttgtccatag gatactttgt aactagtttt atacacatct cttcatcggt 53640 aagtttagac agaatatcgt gaacaggtgg tatattatat tcatcagata tacgaagaac 53700 aatgtccaaa tctatattgt ttaatatatt atatagatgt agcgtagctc ctacaggaat 53760 atctttaact aagtcaatga tttcatcaac cgttagatct attttaaagt taatcatata 53820 ggcattgatt tttaaaaggt atgtagcctt gactacattc tcattaatta accattccaa 53880 gtcactgtgt gtaagaagat tatattctat cataagcttg actacatttg gtcccgatac 53940 cattaaagaa ttcttatgat ataaggaaac agattttagg tactcatcta ctctacaaga 54000 attttggaga gccttaacga tatcagtgac gtttattatt tcaggaggaa agaatctaac 54060 attgagaata tcggaattaa tagcttccag atacagtgat tttggcaata gtccgtgtaa 54120 tccataatcc agtaa cacga gctggtgctt gctagacacc ttttcaatgt ttaatttttt 54180 tgaaataagc tttgataaag ccttcctcgc aaattccgga tacatgaaca tgtcggcgac 54240 atgattaagt attgtttttt cattattttc tcaacaagtt ctcaataccc caatagatga 54300 tagaatatca cccaatgcgt ccatgttgtc tatttccaac aggtcgctat atccaccaat 54360 agaagttttt ccaaaaaaga ttctaggaac agttctacca ccagtaattt gttcaaaata 54420 gtcacgcaat tcattttcgg gtttaaattc tttaatatcg acaatttcat acgctcctct 54480 tttgaaacta aacttattta gaatatccag tgcatttcta caaaaaggac atgtatactt 54540 gacaaaaatt gtcactttgt tattggccaa cctttgttgt acaaattcct cggccatttt 54600 aatatttaag tgatataaaa ctatctcgac ttatttaact ctttagtcga gatatatgga 54660 cgcagatagc tatatgatag ccaactacag aaggcaaacg ctataaaaaa cataattacg 54720 acgagcatat ttataaatat ttttattcag cattacttga tatagtaata ttaggcacag 54780 tcaaacattc aaccactctc gatacattaa ctctctcatt ttctttaaca aattctacaa 54840 tatcttcgta aaaagattct tgaaactttt tagaatatct atcgactcta gatgaaatag 54900 cgttcgtcaa catactatgt tttgtataca taaaggcgcc cattttaaca gtttctagtg 54960 acaaaatgct agcgatccta ggatccttta gaatcacata gattgacgat tcgtctctct 55020 tagtaactct agtaaaataa tcatacaatc tagtacgcga aataatatta tccttgactt 55080 gaggagatct aaacaatcta gttttgagaa catcgataag ttcatcggga atgacataca 55140 tactatcttt aatagaactc ttttcatcca gttgaatgga ttcgtcctta accaactga t 55200 taatgagatc ttctatttta tcattttcca gatgatatgt atgtccatta aagttaaatt 55260 gtgtagcgct tctttttagt ctagcagcca atactttaac atcactaata tcgatataca 55320 aaggagatga tttatctatg gtattaagaa ttcgtttttc gacatctgtc aaaaccaatt 55380 cctttttgcc tgtatcatcc agttttccat cctttgtaaa gaaattattt tctactagac 55440 tattaataag actgataagg attcctccat aattgcacaa tccaaacttt ttaacaaaac 55500 tagactttac aagatctaca ggaatgcgta attcaggttt cttagcttgt gattttttct 55560 tttgtggaca ttttcttgtg accaactcat ctaccatttc attgatttta gcagtgaaat 55620 aagctttcaa tgcacgggca ctgatactat tgaaaacgag ttgatcttca aattccgcca 55680 tttaagttca ccaaacaact tttaaataca aatatatcaa tagtagtaga ataagaacta 55740 taaaaaaaat aataattaac caataccaac cccaacaacc ggtattatta gttgatgtga 55800 ctgttttctc atcacttaga acagatttaa caatttctat aaagtctgtc aaatcatctt 55860 ccggagaccc cataaataca ccaaatatag cggcgtacaa cttatccatt tatacattga 55920 atattggctt ttctttatcg ctatcttcat catattcatc atcaatatca acaagtccca 55980 gattacgagc cagatcttct tctacatttt cagtcattga tacacgttca c tatctccag 56040 agagtccgat aacgttagcc accacttctc tatcaatgat tagtttcttg agtgcgaatg 56100 taatttttgt ttccgttccg gatctataga agacgatagg tgtgataatt gccttggcca 56160 attgtctttc tcttttactg agtgattcta gttcaccttc tatagatctg agaatggatg 56220 attctccagt cgaaacatat tctaccatgg atccgtttaa tttgttgatg aagatggatt 56280 catccttaaa tgttttctct gtaatagttt ccaccgaaag actatgcaaa gaatttggaa 56340 tgcgttcctt gtgcttaatg tttccataga cggcttctag aagttgatac aacataggac 56400 tagccgcggt aacttttatt tttagaaagt atccatcgct tctatcttgt ttagatttat 56460 ttttataaag tttagtctct ccttccaaca taataaaagt ggaagtcatt tgactagata 56520 aactatcagt aagttttata gagatagacg aacaattagc gtattgagaa gcatttagtg 56580 taacgtattc gatacatttt gcattagatt tactaatcga ttttgcatac tctataacac 56640 ccgcacaagt ctgtagagaa tcgctagatg cagtaggtct tggtgaagtt tcaactctct 56700 tcttgattac cttactcatg attaaaccta aataattgta ctttgtaata taatgatata 56760 tattttcact ttatctcatt tgagaataaa aatgtttttg tttaaccact gcatgatgta 56820 cagatttcgg aatcgcaaac caccagtggt tttattttat cctt gtccaa tgtgaattga 56880 atgggagcgg atgcgggttt cgtacgtaga tagtacattc ccgtttttag accgagactc 56940 catccgtaaa aatgcatact cgttagtttg gaataactcg gatctgctat atggatattc 57000 atagattgac tttgatcgat gaaggctccc ctgtctgcag ccatttttat gatcgtcttt 57060 tgtggaattt cccaaatagt tttataaact cgcttaatat cttctggaag gtttgtattc 57120 tgaatggatc caccatctgc cataatccta ttcttgatct catcattcca taattttctc 57180 tcggttaaaa ctctaaggag atgcggatta actacttgaa attctccaga caatactctc 57240 cgagtgtaaa tattactggt atacggttcc accgactcat tatttcccaa aatttgagca 57300 gttgatgcag tcggcatagg tgccaccaat aaactatttc taagaccgta tgttctgatt 57360 ttatctttta gaggttccca attccaaaga tccgacggta caacattcca aagatcatat 57420 tgtagaatac cgttactggc gtacgatcct acatatgtat cgtatggtcc ttccttctca 57480 gctagttcac aactcgcctc taatgcaccg taataaatgg tttcgaagat cttcttattt 57540 agatcttgtg cttccaggct atcaaatgga taatttaaga gaataaacgc gtccgctaat 57600 ccttgaacac caataccgat aggtctatgt ctcttattag agatttcagc ttctggaata 57660 ggataataat taatatctat aattttattg agatttc tga caattacttt gaccacatcc 57720 ttcagtttga gaaaatcaaa tcgcccatct attacaaaca tgttcaaggc aacagatgcc 57780 agattacaaa cggctacctc attagcatcc gcatattgta ttatctcagt gcaaagatta 57840 ctacacttga tagttcctaa attttgttga ttactctttt tgttacacgc atccttataa 57900 agaatgaatg gagtaccagt ttcaatctga gattctataa tcgctttcca gacgactcga 57960 gcctttatta tagatttgta tctcctttct ctttcgtata gtgtatacaa tcgttcgaac 58020 tcgtctcccc aaacattgtc caatccagga cattcatccg gacacatcaa cgaccactct 58080 ccgtcatcct tcactcgttt cataaagaga tcaggaatcc aaagagctat aaatagatct 58140 ctggttctat gttcctcgtt tcctgtattc tttttaagat cgaggaacgc cataatatca 58200 gaatgccacg gttccaagta tatggccata actccaggcc gtttgtttcc tccctgatct 58260 atgtatctag cggtgttatt ataaactctc aacattggaa taataccgtt tgatatacca 58320 ttggtaccgg agatatagct tccactggca cgaatattac taattgatag acctattccc 58380 cctgccattt tagagattaa tgcgcatcgt tttaacgtgt catagatacc ctctatgcta 58440 tcatcgatca tgttaagtag aaaacagcta gacatttggt gacgactagt tcccgcatta 58500 aataaggtag gagaagcgtg cgtaaaccat ttttcagaaa gtagattgta cgtctcaata 58560 gctgagtcta tatcccattg atgaattcct actgcgacac gcattaacat gtgctgaggt 58620 ctttcaacga tcttgttgtt tattttcaac aagtaggatt tttccaaagt tttaaaacca 58680 aaatagttgt atgaaaagtc tcgttcgtaa ataataaccg agttgagttt atccttatat 58740 ttgttaacta tatccatggt gatacttgaa ataatcggag aatgtttccc atttttagga 58800 ttaacatagt tgaataaatc ctccatcact tcactaaata gtttttttgt ttccttgtgt 58860 agatttgata cggctattct ggcggctaga atggcataat ccggatgttg tgtagtacaa 58920 gtggctgcta tttcggctgc cagagtgtcc aattctaccg ttgttactcc attatatatt 58980 ccttgaataa ccttcatagc tattttaata ggatctatat gatccgtgtt taagccataa 59040 cataattttc taatacgaga cgtgatttta tcaaacatga cattttcctt gtatccattt 59100 cgtttaatga caaacatttt tgttggtgta ataaaaaaaa ttatttaact tttcattaat 59160 agggatttga cgtatgtagc gtacaaaatt atcgttcctg gtatatagat aaagagtcct 59220 atatatttga aaatcgttac ggctcgatta aactttaatg attgcatagt gaatatatca 59280 ttaggattta actccttgac tatcatggcg gcgccagaaa ttaccatcaa aagcattaat 59340 acagttatgc cgatcgcagt ta gaacggtt atagcatcca ccatttatat ctaaaaatta 59400 gatcaaagaa tatgtgacaa agtcctagtt gtatactgag aattgacgaa acaatgtttc 59460 ttacatattt tttttttatt agtaaccgac ttaatagtag gaactggaaa actagacttg 59520 attattctat aagtatagat acccttccaa ataatattct ctttgataaa agttccagaa 59580 aatgtagaat tttttaaaaa gttatctttt gctattacca agattgtgtt tagacgctta 59640 ttattaatat gagtgatgaa atccacaccg cctctagata tcgcttttat ttccacatta 59700 gatggtaaat ccaatagtga aactatcttt ttaggaatgt atggactcgc gtttagagga 59760 gtgaacgtct taggcgtcgg aaaggggccg gccttttttt ctagacacta aataaatagt 59820 aagattaaat taattataaa attatgtata taatattaat tataaaatta tgtatatgat 59880 tactaactt tagttagata aattataataat acataaattta 60 attatatatta atattataaa 59940 cctatta atattataaaa 59940 ttaatagtata atatata <210> 13
<211> 63035
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA fragment 2
<400> 13 ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60 attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120 aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180 gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccataa 240 aaatgttttt gtttaaccac tgcatgatgt acagatttcg gaatcgcaaa ccaccagtgg 300 ttttatttta tccttgtcca atgtgaattg aatgggagcg gatgcgggtt tcgtacgtag 360 atagtacatt cccgttttta gaccgagact ccatccgtaa aaatgcatac tcgttagttt 420 ggaataactc ggatctgcta tatggatatt catagattga ctttgatcga tgaaggctcc 480 cctgtctgca gccattttta tgatcgtctt ttgtggaatt tcccaaatag ttttataaac 540 tcgcttaata tcttctggaa ggtttgtatt ctgaatggat ccaccatctg ccataatcct 600 attcttgatc tcatcattcc ataattttct ctcggttaaa actctaagga gatgcggatt 660 aactacttga aattctccag acaatactct ccgagtgtaa atattactgg tatacggttc 720 caccgactca ttatttccca aaatttgagc agttgatgca gtcggcatag gtgccaccaa 780 taaactattt ctaagaccgt atgttctgat tttatctttt agaggttccc aattccaaag 840 atccgacggt a caacattcc aaagatcata ttgtagaata ccgttactgg cgtacgatcc 900 tacatatgta tcgtatggtc cttccttctc agctagttca caactcgcct ctaatgcacc 960 gtaataaatg gtttcgaaga tcttcttatt tagatcttgt gcttccaggc tatcaaatgg 1020 ataatttaag agaataaacg cgtccgctaa tccttgaaca ccaataccga taggtctatg 1080 tctcttatta gagatttcag cttctggaat aggataataa ttaatatcta taattttatt 1140 gagatttctg acaattactt tgaccacatc cttcagtttg agaaaatcaa atcgcccatc 1200 tattacaaac atgttcaagg caacagatgc cagattacaa acggctacct cattagcatc 1260 cgcatattgt attatctcag tgcaaagatt actacacttg atagttccta aattttgttg 1320 attactcttt ttgttacacg catccttata aagaatgaat ggagtaccag tttcaatctg 1380 agattctata atcgctttcc agacgactcg agcctttatt atagatttgt atctcctttc 1440 tctttcgtat agtgtataca atcgttcgaa ctcgtctccc caaacattgt ccaatccagg 1500 acattcatcc ggacacatca acgaccactc tccgtcatcc ttcactcgtt tcataaagag 1560 atcaggaatc caaagagcta taaatagatc tctggttcta tgttcctcgt ttcctgtatt 1620 ctttttaaga tcgaggaacg ccataatatc agaatgccac ggttccaagt atatggccat 1680 aactccaggc cgtttgttt c ctccctgatc tatgtatcta gcggtgttat tataaactct 1740 caacattgga ataataccgt ttgatatacc attggtaccg gagatatagc ttccactggc 1800 acgaatatta ctaattgata gacctattcc ccctgccatt ttagagatta atgcgcatcg 1860 ttttaacgtg tcatagatac cctctatgct atcatcgatc atgttaagta gaaaacagct 1920 agacatttgg tgacgactag ttcccgcatt aaataaggta ggagaagcgt gcgtaaacca 1980 tttttcagaa agtagattgt acgtctcaat agctgagtct atatcccatt gatgaattcc 2040 tactgcgaca cgcattaaca tgtgctgagg tctttcaacg atcttgttgt ttattttcaa 2100 caagtaggat ttttccaaag ttttaaaacc aaaatagttg tatgaaaagt ctcgttcgta 2160 aataataacc gagttgagtt tatccttata tttgttaact atatccatgg tgatacttga 2220 aataatcgga gaatgtttcc catttttagg attaacatag ttgaataaat cctccatcac 2280 ttcactaaat agtttttttg tttccttgtg tagatttgat acggctattc tggcggctag 2340 aatggcataa tccggatgtt gtgtagtaca agtggctgct atttcggctg ccagagtgtc 2400 caattctacc gttgttactc cattatatat tccttgaata accttcatag ctattttaat 2460 aggatctata tgatccgtgt ttaagccata acataatttt ctaatacgag acgtgatttt 2520 atcaaacatg acattttcct tgta tccatt tcgtttaatg acaaacattt ttgttggtgt 2580 aataaaaaaa attatttaac ttttcattaa tagggatttg acgtatgtag cgtacaaaat 2640 tatcgttcct ggtatataga taaagagtcc tatatatttg aaaatcgtta cggctcgatt 2700 aaactttaat gattgcatag tgaatatatc attaggattt aactccttga ctatcatggc 2760 ggcgccagaa attaccatca aaagcattaa tacagttatg ccgatcgcag ttagaacggt 2820 tatagcatcc accatttata tctaaaaatt agatcaaaga atatgtgaca aagtcctagt 2880 tgtatactga gaattgacga aacaatgttt cttacatatt ttttttttat tagtaaccga 2940 cttaatagta ggaactggaa aactagactt gattattcta taagtataga tacccttcca 3000 aataatattc tctttgataa aagttccaga aaatgtagaa ttttttaaaa agttatcttt 3060 tgctattacc aagattgtgt ttagacgctt attattaata tgagtgatga aatccacacc 3120 gcctctagat atcgctttta tttccacatt agatggtaaa tccaatagtg aaactatctt 3180 tttaggaatg tatggactcg cgtttagagg agtgaacgtc ttaggcgtcg gaaaggatga 3240 ttcatcaaac gaataaacaa tttcacaaat ggatgttaat gtattagtag gaaatttttt 3300 gacgctagtg gaattgaaga ttctaatgga tgatgttcta cctatttcat ccgataacat 3360 gttaatttcc gacaccaacg gttttaatat ttcgatgata tacggtagtc tctctttcgg 3420 acttatatag cttattccac aatacgagtc attatatact ccaaaaaaca aaataactag 3480 tataaaatct gtatcgaatg ggaaaaacga aattatcgac ataggtatag aatctggaac 3540 attgaacgta ttaatactta attctttttc tgtggtaagt accgataggt tattgacatt 3600 gtatggtttt aaatattcta taacttgaga cttgatagat attagtgatg aattgaaaat 3660 tatttttatc accacgtgtg tttcaggatc atcgtcgacg cccgtcaacc aaccgaatgg 3720 agtaaaataa atatcattaa tatatgctct agatattagt atttttatca atcctttgat 3780 tatcatcttc tcgtaggcga atgattccat gatcaagagt gatttaagaa catcctccgg 3840 agtattaatg ggcttagtaa acagtccatc gttgcaataa taaaagttat ccaagttaaa 3900 ggatattatg cattcgttta aagatatcac ctcatctgac ggagacaatt ttttggtagg 3960 ttttagagac tttgaagcta cttgtttaac aaagttattc atcgtcgttt actattctat 4020 ttaattttgt agttaattta tcacatatca cattaattga ctttttggtc catttttcca 4080 tacgtttata ttcttttaat cctgcgttat ccgtttccgt tatatccagg gatagatctt 4140 gcaagttaaa tagaatgctc ttaaataatg tcattttctt atccgctaaa aatttaaaga 4200 atgtataaac ctttttcaga gatttgaaac tctta ggtgg tgtcctagta cacaatatca 4260 taaacaaact aataaacatt ccacattcag attccaacag ctgattaact tctacattaa 4320 tacagcctat tttcgctcca aatgtacatt cgaaaaatct gaataaaaca tcgatgtcac 4380 aatttgtatt atccaataca gaatgtttgt gattcgtgtt aaaaccatcg gagaaggaat 4440 aaaaataaaa attattatag tggtggaatt cagttggaat attgcctccg gagtcataaa 4500 aggatactaa acattgtttt ttatcataaa ttacacattt ccaatgagac aaataacaaa 4560 atccaaacat tacaaatcta gaggtagaac ttttaatttt gtctttaagt atatacgata 4620 agatatgttt attcataaac gcgtcaaatt tttcatgaat cgctaaggag tttaagaatc 4680 tcatgtcaaa ttgtcctata taatccactt cggatccata agcaaactga gagactaagt 4740 tcttaatact tcgattgctc atccaggctc ctctctcagg ctctattttc atcttgacga 4800 cctttggatt ttcaccagta tgtattcctt tacgtgataa atcatcgatt ttcaaatcca 4860 tttgtgagaa gtctatcgcc ttagatactt tttcccgtag tcgaggttta aagaaatacg 4920 ctaacggtat actagtaggt aactcaaaga catcatatat agaatggtaa cgcgtcttta 4980 actcgtcggt taactctttc ttttgatcga gttcgtcgct actattgggt ctgctcaggt 5040 gccccgactc tactagttcc aacatcatac cgataggaat acaagacact ttgccggcgg 5100 ttgtagattt atcatatttc tccactacat atccgttaca atttgttaaa aatttagata 5160 catctatatt gctacataat ccagctagtg aatatatatg acataataaa ttggtaaatc 5220 ctagttctgg tattttacta attactaaat ctgtatatct ttccatttat catggaaaag 5280 aatttaccag atatcttctt ttttccaaac tgcgttaatg tattctctta caaatattca 5340 caagatgaat tcagtaatat gagtaaaacg gaacgtgata gtttctcatt ggcggtgttt 5400 ccagttataa aacatagatg gcataacgca cacgttgtaa aacataaagg aatatacaaa 5460 gttagtacag aagcacgtgg aaaaaaagta tctcctccat cactaggaaa acccgcacac 5520 ataaacctaa ccgcgaagca atatatatac agtgaacaca caataagctt tgaatgttat 5580 agttttctaa aatgtataac aaatacagaa atcaattcgt tcgatgagta tatattaaga 5640 ggactattag aagctggtaa tagtttacag atattttcca attccgtagg taaacgaaca 5700 gatactatag gtgtactagg gaataagtat ccatttagca aaattccatt ggcctcatta 5760 actcctaaag cacaacgaga gatattttca gcgtggattt ctcatagacc tgtagtttta 5820 actggaggaa ctggagtggg taagacgtca caggtaccca agttattgct ttggtttaat 5880 tatttatttg gtggattctc tactctagat aaaatcactg actttc acga aagaccagtc 5940 attctatctc ttcctaggat agctttagtt agattgcata gcaataccat tttaaaatca 6000 ttgggattta aggtactaga tggatctcct atttctttac ggtacggatc tataccggaa 6060 gaattaataa acaaacaacc aaaaaaatat ggaattgtat tttctaccca taagttatct 6120 ctaacaaaac tatttagtta tggcactctt attatagacg aagttcatga gcatgatcaa 6180 ataggagata ttattatagc agtagcgaga aagcatcata cgaaaataga ttctatgttt 6240 ttaatgactg ccacgttaga ggatgacagg gaacggctaa aagtattttt acctaatccc 6300 gcatttatac atattcctgg agatacactg tttaaaatta gcgaggtatt tattcataat 6360 aagataaatc catcttccag aatggcatac atagaagaag aaaagagaaa tttagttact 6420 gctatacaga tgtatactcc tcctgatgga tcatccggta tagtctttgt ggcatccgtt 6480 gcacagtgtc acgaatataa atcatattta gaaaaaagat taccgtatga tatgtatatt 6540 attcatggta aggtcttaga tatagacgaa atattagaaa aagtgtattc atcacctaat 6600 gtatcgataa ttatttctac tccttatttg gaatccagcg ttactatacg caatgttaca 6660 cacatttatg atatgggtag agtttttgtc cccgctcctt ttggaggatc gcaagaattt 6720 atttctaaat ctatgagaga tcaacgaaaa ggaagagtag gaagagttaa t cctgggaca 6780 tacgtatatt tctatgatct gtcttatatg aagtctatac agcgaataga ttcagaattt 6840 ctacataatt atatattgta cgctaataag tttaatctaa cactccccga agatttgttt 6900 ataatcccta caaatttgga tattctatgg cgtacaaagg aatatataga ctcgttcgat 6960 attagtacag aaacatggaa taaattatta tccaattatt atatgaagat gatagagtat 7020 gctaaacttt atgtactaag tcctattctc gctgaggagt tggataattt tgagaggacg 7080 ggagaattaa ctagtattgt acaagaagcc attttatctc taaatttacg aattaagatt 7140 ttaaatttta aacataaaga tgatgatacg tatatacact tttgtaaaat attattcggt 7200 gtctataacg gaacaaacgc tactatatat tatcatagac ctctaacggg atatatgaat 7260 atgatttcag atactatatt tgttcctgta gataataact aaaaatcaaa ctctaatgac 7320 cacatctttt tttagagatg aaaaattttc cacatctcct tttgtagaca cgactaaaca 7380 ttttgcagaa aaaagtttat tagtgtttag ataatcgtat acttcatcag tgtagatagt 7440 aaatgtgaac agataaaagg tattcttgct caatagattg gtaaattcca tagaatatat 7500 taatcctttc ttcttgagat cccacatcat ttcaaccaga gacgttttat ccaatgattt 7560 acctcgtact ataccacata caaaactaga ttttgcagtg acgtcgtatc tggtatt cct 7620 accaaacaaa attttacttt tagttctttt agaaaattct aaggtagaat ctctatttgc 7680 caatatgtca tctatggaat taccactagc aaaaaatgat agaaatatat attgatacat 7740 cgcagctggt tttgatctac tatactttaa aaacgaatca gattccataa ttgcctgtat 7800 atcatcagct gaaaaactat gttttacacg tattccttcg gcatttcttt ttaatgatat 7860 atcttgttta gacaatgata aagttatcat gtccatgaga gacgcgtctc cgtatcgtat 7920 aaatatttca ttagatgtta gacgcttcat taggggtata cttctataag gtttcttaat 7980 cagtccatca ttggttgcgt caagaactac tatcggatgt tgttgggtat ctctagtgtt 8040 acacatggcc ttactaaagt ttgggtaaat aactatgata tctctattaa ttatagatgc 8100 atatatttca tttgtcaagg atattagtat cgacttgcta tcgtcattaa tacgtgtaat 8160 gtaatcatat aaatcatgcg atagccaagg aaaatttaaa tagatgttca tcatataatc 8220 gtcgctataa ttcatattaa tacgttgaca ttgactaatt tgtaatatag cctcgccacg 8280 aagaaagctc tcgtattcag tttcatcgat aaaggatacc gttaaatata actggttgcc 8340 gatagtctca tagtctatta agtggtaagt ttcgtacaaa tacagaatcc ctaaaatatt 8400 atctaatgtt ggattaatct ttaccataac tgtataaaat ggagacggag tcataactat 84 60 tttaccgttt gtacttactg gaatagacga aggaataatc tccggacatg ctggtaaaga 8520 cccaaatgtc tgtttgaaga aatccaatgt tccaggtcct aatctcttaa caaaaattac 8580 gatattcgat cccgatatcc tttgcattct atttaccagc atatcacgaa ctatattaag 8640 attatctatc atgtctattc tcccaccgtt atataaatcg cctccgctaa gaaacgttag 8700 tatatccata caatggaata cttcatttct aaaatagtat tcgttttcta attctttaat 8760 gtgaaatcgt atactagaaa gggaaaaatt atctttgagt tttccgttag aaaagaacca 8820 cgaaactaat gttctgattg cgtccgattc cgttgctgaa ttaatggatt tacaccaaaa 8880 actcatataa cttctagatg tagaagcatt cgctaaaaaa ttagtagaat caaaggatat 8940 aagtagatgt tccaacaagt gagcaattcc caagatttca tctatatcat tctcgaatcc 9000 gaaattagaa attcccaagt agatatcctt tttcatccga tcgttgatga aaatacgaac 9060 tttattcggt aagacaatca tttactaagg agtaaaatag gaagtaatgt tcgtatgtcg 9120 ttatcatcgt ataaattaaa ggtgtgtttt ttaccattaa gtgacattat aattttacca 9180 atattggaat tataatatag gtgtatttgc gcactcgcga cggttgatgc atcggtaaat 9240 atagctgtat ctaatgttct agtcggtatt tcatcatttc gctgtctaat aatagcgttt 9300 tct ctatctg tttccattac agctgcctga agtttattgg tcggataata tgtaaaataa 9360 taagaaatac atacgaataa caaaaataaa ataagatata ataaagatgc catttagaga 9420 tctaattttg tttaacttgt ccaaattcct acttacagaa gatgaggaat cgttggagat 9480 agtgtcttcc ttatgtagag gatttgaaat atcttatgat gacttgataa cttactttcc 9540 agataggaaa taccataaat atatttctaa agtatttgaa catgtagatt tatcggagga 9600 attaagtatg gaattccatg atacaactct gagagattta gtctatctta gattgtacaa 9660 gtattccaag tgtatacggc cgtgttataa attaggagat aatctaaaag gcatagttgt 9720 tataaaggac aggaatattt atattagaga agcaaatgat gacttgatag aatatctcct 9780 caaggaatac actcctcaga tttatacata ttctaatgag cgcgtcccca taactggttc 9840 aaaattaatt ctttgtggat tttctcaagt tacatttatg gcgtatacaa cgtcgcatat 9900 aacaacaaat aaaaaggtag atgttctcgt ttccaaaaaa tgtatagatg aactagtcga 9960 tccaataaat tatcaaatac ttcaaaattt atttgataaa ggaagcggaa caataaacaa 10020 aatactcagg aagatatttt attcggtaac cggtggccaa actccataat ttgctttttc 10080 tatttcggat tttagaattt ccaaattcac cagcgattta tcggttttgg tgaaatccaa 10140 ggattt atta atgtccacaa atgccatttg ttttgtctgt ggattgtatt tgaaaatgga 10200 aacgatgtag ttagatagat gcgctgcaaa gtttcctatt agggttccgc gctttacgtc 10260 acccagcata cttgaatcac catcctttaa aaaaaatgat aagatatcaa catggagtat 10320 atcatactcg gattttaatt cttctactgc atcactgaca ttttcacaaa tactacaata 10380 cggtttaccg aaaataatca gtacgttctt catttatggg tatcaaaaac ttaaaatcgt 10440 tactgctgga aaataaatca ctgacgatat tagatgataa tttatacaaa gtatacaatg 10500 gaatatttgt ggatacaatg agtatttata tagccgtcgc caattgtgtc agaaacttag 10560 aagagttaac tacggtattc ataaaatacg taaacggatg ggtaaaaaag ggagggcatg 10620 taaccctttt tatcgataga ggaagtataa aaattaaaca agacgttaga gacaagagac 10680 gtaaatattc taaattaacc aaggacagaa aaatgctaga attagaaaag tgtacatccg 10740 aaatacaaaa tgttaccgga tttatggaag aagaaataaa ggcagaaatg caattaaaaa 10800 tcgataaact cacatttcaa atatatttat ctgattctga taacataaaa atatcattga 10860 atgagatact aacacatttc aacaataatg agaatgttac attattttat tgtgatgaac 10920 gagacgcaga attcgttatg tgtctcgagg ctaaaacaca tttctctacc acaggagaat 1098 0 ggccgttgat aataagtacc gatcaggata ctatgctatt tgcatctact gataatcatc 11040 ctaagatgat aaaaaactta actcaactgt ttaaatttgt tccctcggca gaggataact 11100 atttagcaaa attaacggcg ttagtgaatg gatgtgattt ctttcctgga ctctatgggg 11160 catctataac acccaccaac ttaaacaaaa tacaattgtt tagtgatttt acaatcgata 11220 atatagtcac tagtttggca attaaaaatt attatagaaa gactaactct accgtagacg 11280 tgcgtaatat tgttacgttt ataaacgatt acgctaattt agacgatgtc tactcgtatg 11340 ttcctccttg tcaatgcact gttcaagaat ttatattttc cgcattagat gaaaaatgga 11400 acaattttaa atcatcttat ttagagaccg ttccgttacc ctgccaatta atgtatgcat 11460 tagaaccacg caaggagatt gatgtttcag aagttaaaac tttatcatct tatatagatt 11520 tcgaaaatac taaatcagat atcgatgtta taaaatctat atcttcgatc ttcggatatt 11580 ctaacgaaaa ctgtaacact atagtgttcg gcatctataa ggataattta ctactgagta 11640 taaatagttc attttacttt aacgatagtc tgttaataac caatactaaa agtgataata 11700 taataaatat aggttactag attaaaaatg gtgttccaac tcgtgtgctc tacgtgcggc 11760 aaagatattt ctcacgaacg atataaattg attatacgaa aaaaatcatt aaaggat gta 11820 ctcgtcagtg taaagaacga atgttgtagg ttaaaattat ctacacaaat agaacctcaa 11880 cgtaacttaa cagtgcaacc tctattggat ataaactaat atggatccgg ttaattttat 11940 caagacatat gcgcctagag gttctattat ttttattaat tataccatgt cattaacaag 12000 tcatttgaat ccatcgatag aaaaacatgt gggtatttat tatggtacgt tattatcgga 12060 acacttggta gttgaatcta cctatagaaa aggagttcga atagtcccat tggatagttt 12120 ttttgaagga tatcttagtg caaaagtata catgttagag aatattcaag ttatgaaaat 12180 agcagctgat acgtcattaa ctttattggg tattccgtat ggatttggtc ataatagaat 12240 gtattgtttt aaattggtag ctgaatgtta taaaaatgcc ggtattgata catcgtctaa 12300 acgaatatta ggtaaagata tttttctgag ccaaaacttc acagatgata atagatggat 12360 aaagatatat gattctaata atttaacatt ttggcaaatt gattacctta aagggtgagt 12420 taatatgcat aactactcct ccgttgtttt ttccctcgtt ctttttctta acgttgtttg 12480 ccatcactct cataatgtaa agatattcta aaatggtaaa cttttgcata tcggacgcag 12540 aaattggtat aaatgttgta attgtattat ttcccgtcaa tggactagtc acagctccat 12600 cagttttata tcctttagag tatttctcac tcgtgtctaa cattctagag cattccatga 12660 tctgtttatc gttgatattg gccggaaaga tagatttttt attttttatt atattactat 12720 tggcaattgt agatataact tctggtaaat atttttctac cttttcaatc tcttctattt 12780 tcaagccggc tatatattct gctatattgt tgctagtatc aatacctttt ctggctaaga 12840 agtcatatgt ggtattcact atatcagttt taactggtag ttccattagc ctttccactt 12900 ctgcagaata atcagaaatt ggttctttac cagaaaatcc agctactata ataggctcac 12960 cgatgatcat tggcaaaatc ctatattgta ccagattaat gagagcatat ttcatttcca 13020 ataattctgc tagttcttga gacattgatt tatttgatga atctagttgg ttctctagat 13080 actctaccat ttctgccgca tacaataact tgttagataa aatcagggtt atcaaagtgt 13140 ttagcgtggc tagaatagtg ggcttgcatg tattaaagaa tgcggtagta tgagtaaacc 13200 gttttaacga attatatagt ctccagaaat ctgtggcgtt acatacatga gccgaatgac 13260 atcgaagatt gtccaatatt tttaatagct gctctttgtc cattatttct atatttgact 13320 cgcaacaatt gtagatacca ttaatcactg attccttttt cgatgccgga caatagcaca 13380 attgtttagc tttggactct atgtattcag aattaataga tatatctctc aatacagatt 13440 gcactataca ttttgaaact atgtcaaaaa ttgtagaacg ac gctgttct gcagccattt 13500 aactttaaat aatttacaaa aatttaaaat gagcatccgt ataaaaatcg ataaactgcg 13560 ccaaattgtg gcatattttt cagagttcag tgaagaagta tctataaatg tagactcgac 13620 gggatgagtta at gccattaatg tagactcgac 13620 gggatgagtta at acctctcagt gcatcagtgt tctaccgcgg agccgaaaac attgtgttta atcttcctgt 13740 gtccaaggta aaatcgtgtt tgtgtagttt tcacaatgat gccatcatag atatagaacc 13800 tgatctggaa aataatctag taaaactttc tagttatcat gtagtaagtg tcgattgtaa 13860 caaggaactg atgcctatta ggacagatac tactatttgt ctaagtatag atcaaaagaa 13920 atcttacgtg tttaattttc acaagtatga agaaaaatgt tgtggtagaa ccgtcattca 13980 tttagaatgg ttgttgggct ttatcaagtg tattagtcag catcagcatt tggctattat 14040 gtttaaagat gacaatatta ttatgaagac tcctggtaat actgatgcgt tttccaggga 14100 atattctatg actgaatgtt ctcaagaact acaaaagttt tctttcaaaa tagctatctc 14160 gtctctcaac aaactacgag gattcaaaaa gagagtcaat gtttttgaaa ctagaatcgt 14220 aatggataat gacgataaca ttctaggaat gttgttttcg gatagagttc aatcctttaa 14280 gatcaacatc tttatgacgt ttttagatta atactttcaa tgagataaat atgggtggca 14340 gagtaagtgt tgagctccct aaacgggatc cgcctccggg agtacccact gatgagatgt 14400 tattaaacgt ggataaaatg catgacgtga tagctcccgc taagctttta gaatatgtgc 14460 atataggacc actagcaaaa gataaagagg ataaagtaaa gaaaagatat ccagagttt a 14520 gattagtcaa cacaggaccc ggtggtcttt cggcattgtt aagacaatcg tataatggaa 14580 ccgcacccaa ttgctgtcgc acttttaatc gtactcatta ttggaaaaag gatggaaaga 14640 tatcagataa gtatgaagag ggtgcagtat tagaatcgtg ttggccagac gttcacgaca 14700 ctggaaaatg cgatgttgat ttattcgact ggtgtcaggg ggatacgttc gatagaaaca 14760 tatgccatca gtggatcggt tcagccttta ataggagtga tagaactgta gagggtcaac 14820 aatcgttaat aaatctgtat aataagatgc aaacattatg tagtaaagat gctagtgtac 14880 caatatgtga atcatttttg catcatttac gcgcacacaa tacagaagat agcaaagaga 14940 tgatcgatta tattctaaga caacagtctg cggactttaa acagaaatat atgagatgta 15000 gttatcccac tagagataag ttagaagagt cattaaaata tgcggaacct cgagaatgtt 15060 gggatccaga gtgttcgaat gccaatgtta atttcttact aacacgtaat tataataatt 15120 taggactttg caatattgta cgatgtaata ctagcgtgaa caacttacag atggataaaa 15180 cttcctcatt aagattgtca tgtggattaa gcaatagtga tagattttct actgttcccg 15240 tcaatagagc aaaagtagtt caacataata ttaaacattc gttcgaccta aaattgcatt 15300 tgatcagttt attatctctc ttggtaatat ggatactaat tgtagctatt t aaatgggtg 15360 ccgcggcaag catacagacg acggtgaata cactcagcga acgtatctcg tctaaattag 15420 aacaagaagc gaacgctagt gctcaaacaa aatgtgatat agaaatcgga aatttttata 15480 tccgacaaaa ccatggatgt aacctcactg ttaaaaatat gtgctctgcg gacgcggatg 15540 ctcagttgga tgctgtgtta tcagccgcta cagaaacata tagtggatta acaccggaac 15600 aaaaagcata cgtaccagct atgtttactg ctgcgttaaa cattcagacg agtgtaaaca 15660 ctgttgttag agattttgaa aattatgtga aacagacttg taattctagc gcggtcgtcg 15720 ataacaaatt aaagatacaa aacgtaatca tagatgaatg ttacggagcc ccaggatctc 15780 caacaaattt ggaatttatt aatacaggat ctagcaaagg aaattgtgcc attaaagcgt 15840 tgatgcaatt gacgactaag gccactactc aaatagcacc tagacaagtt gctggtacag 15900 gagttcagtt ttatatgatt gttatcggtg ttataatatt ggcagcgttg tttatgtact 15960 atgccaagcg tatgttgttc acatccacca atgataaaat caaacttatt ttagccaata 16020 aggaaaacgt ccattggact acttacatgg acacattctt tagaacttct ccgatggtta 16080 ttgctaccac ggatatgcaa aactgaaaat atattgataa tattttaata gattaacatg 16140 gaagttatcg ctgatcgtct agacgatata gtgaaacaaa atat agcgga tgaaaaattt 16200 gtagattttg ttatacacgg tctagagcat caatgtcctg ctatacttcg accattaatt 16260 aggttgttta ttgatatact attatttgtt atagtaattt atatttttac ggtacgtcta 16320 gtaagtagaa attatcaaat gttgttggcg ttggtggcgc tagtcatcac attaactatt 16380 ttttattact ttatactata atagtactag actgacttct aacaaacatc tcacctgcca 16440 taaataaatg cttgatatta aagtcttcta tttctaacac tattccatct gtggaaaata 16500 atactctgac attatcgcta attgacacat cggtgagtga tatgcctata aagtaataat 16560 cttctttggg cacatatacc agtgtaccag gttctaacaa cctatttact ggtgctcctg 16620 tagcatactt tttctttacc ttgagaatat ccatcgtttg cttggtcaat agcgatatgt 16680 gattttttat caaccactca aaaaagtaat tggagtgttc atatcctcta cgggctattg 16740 tctcatggcc gtgtatgaaa tttaagtaac acgactgtgg tagatttgtt ctatagagcc 16800 ggttgccgca aatagataga actaccaata tgtctgtaca aatgttaaac attaattgat 16860 taacagaaaa aacaatgttc gttctgggaa tagaaaccag atcaaaacaa aattcgttag 16920 aatatatgcc acgtttatac atggaatata aaataactac agtttgaaaa ataacagtat 16980 catttaaaca tttaacttgc ggggttaatt tcacaac ttt actgttttta aactgttcaa 17040 aatatagcat cgatccatga gaaatacgtt tagccgcctt taatagagga aatcccaccg 17100 cctttctgga tctcaccaac gacgatagtt ctgaccagca acttatttct tcatcatcca 17160 cctgttttaa catataatag gcaggagata gatatccgtc attgcaatat tccttttcgt 17220 aggcacacaa tctaatattg ataaaatctc cattctcttc tctgcattta ttatcttgtt 17280 tcggtggctg attaggctgt agtcttggtt taggctttgg tatatcgttg ttgaatctat 17340 tttggtcatt aaatctttca tttcttcctg gtatatttct atcacctcgt ttggttggat 17400 ttttgtctat attatcgttt gtaacatcgg tacgggtatt catttatcac aaaaaaaact 17460 tctctaaatg agtctactgc tagaaaacct catcgaagaa gataccatat tttttgcagg 17520 aagtatatct gagtatgatg atttacaaat ggttattgcc ggcgcaaaat ccaaatttcc 17580 aagatctatg ctttctattt ttaatatagt acctagaacg atgtcaaaat atgagttgga 17640 gttgattcat aacgagaata tcacaggggc aatgtttacc acaatgtata atataagaaa 17700 caatttgggt ctaggagatg ataaactaac tattgaagcc attgaaaact atttcttgga 17760 tcctaacaat gaggttatgc ctcttatcat taataatacg gatatgactg ccgtcattcc 17820 taaaaaaagt ggtaggagaa agaataagaa catggttatt ttccgtcaag gatcatcacc 17880 tatcttgtgt attttcgaaa ctcgtaaaaa gattaatatt tataaagaaa atatggaatc 17940 cgcgtcgact gagtatacac ctatcggaga caacaaggct ttgatatcta aatatgcggg 18000 aattaatgtc ctgaatgtgt attctccttc cacatccatg agattgaatg ccatttacgg 18060 attcaccaat aaaaataaac tagagaaact tagtactaat aaggaactag aatcgtatag 18120 ttctagccct cttcaagaac ccattaggtt aaatgatttt ctgggactat tggaatgtgt 18180 taaaaagaat attcctctaa cagatattcc gacaaaggat tgattactat aaatggagaa 18240 tgttcctaat gtatacttta atcctgtgtt tatagagccc acgtttaaac attctttatt 18300 aagtgtttat aaacacagat taatagtttt atttgaagta ttcattgtat tcattctaat 18360 atatgtattt tttagatctg aattaaatat gttcttcatg cctaaacgaa aaatacccga 18420 tcctattgat agattacgac gtgctaatct agcgtgtgaa gacgataaat taatgatcta 18480 tggattacca tggatgacaa ctcaaacatc tgcgttatca ataaatagta aaccgatagt 18540 gtataaagat tgtgcaaagc ttttgcgatc aataaatgga tcacaaccag tatctcttaa 18600 cgatgttctt cgcagatgat gattcatttt ttaagtattt ggctagtcaa gatgatgaat 18660 cttcattatc tgatatattg ca aatcactc aatatctaga ctttctgtta ttattattga 18720 tccaatcaaa aaataaatta gaagccgtgg gtcattgtta tgaatctctt tcagaggaat 18780 acagacaatt gacaaaattc acagactttc aagattttaa aaaactgttt aacaaggtcc 18840 ctattgttac agatggaagg gtcaaactta ataaaggata tttgttcgac tttgtgatta 18900 gtttgatgcg attcaaaaaa gaatcctctc tagctaccac cgcaatagat cctattagat 18960 acatagatcc tcgtcgcgat atcgcatttt ctaacgtgat ggatatatta aagtcgaata 19020 aagtgaacaa taattaattc tttattgtca tcatgaacgg cggacatatt cagttgataa 19080 tcggccccat gttttcaggt aaaagtacag aattaattag acgagttaga cgttatcaaa 19140 tagctcaata taaatgcgtg actataaaat attctaacga taatagatac ggaacgggac 19200 tatggacgca tgataagaat aattttgaag cattggaagc aactaaacta tgtgatgtct 19260 tggaatcaat tacagatttc tccgtgatag gtatcgatga aggacagttc tttccagaca 19320 ttgttgaatt ctgtgagcgt atggcaaacg aaggaaaaat agttatagta gccgcactcg 19380 atgggacatt tcaacgtaaa ccgtttaata atattttgaa tcttattcca ttatctgaaa 19440 tggtggtaaa actaactgct gtgtgtatga aatgctttaa ggaggcttcc ttttctaaac 19500 gattgggtga ggaaa ccgag atagagataa taggaggtaa tgatatgtat caatcggtgt 19560 gtagaaagtg ttacgtcggc tcataatatt atatttttta tctaaaaaac taaaaataaa 19620 cattgattaa attttaatat aatacttaaa aatggatgtt gtgtcgttag ataaaccgtt 19680 tatgtatttt gaggaaattg ataatgagtt agattacgaa ccagaaagtg caaatgaggt 19740 cgcaaaaaaa ctgccgtatc aaggacagtt aaaactatta ctaggagaat tattttttct 19800 tagtaagtta cagcgacacg gtatattaga tggtgccacc gtagtgtata taggatctgc 19860 tcccggtaca catatacgtt atttgagaga tcatttctat aatttaggag tgatcatcaa 19920 atggatgcta attgacggcc gccatcatga tcctatttta aatggattgc gtgatgtgac 19980 tctagtgact cggttcgttg atgaggaata tctacgatcc atcaaaaaac aactgcatcc 20040 ttctaagatt attttaattt ctgatgtgag atccaaacga ggaggaaatg aacctagtac 20100 ggcggattta ctaagtaatt acgctctaca aaatgtcatg attagtattt taaaccccgt 20160 ggcgtctagt cttaaatgga gatgcccgtt tccagatcaa tggatcaagg acttttatat 20220 cccacacggt aataaaatgt tacaaccttt tgctccttca tattcagctg aaatgagatt 20280 attaagtatt tataccggtg agaacatgag actgactcga gttaccaaat cagacgctgt 20340 aaattatg aa aaaaagatgt actaccttaa taagatcgtc cgtaacaaag tagttgttaa 20400 ctttgattat cctaatcagg aatatgacta ttttcacatg tactttatgc tgaggaccgt 20460 gtactgcaat aaaacatttc ctactactaa agcaaaggta ctatttctac aacaatctat 20520 atttcgtttc ttaaatattc caacaacatc aactgaaaaa gttagtcatg aaccaataca 20580 acgtaaaata tctagcaaaa attctatgtc taaaaacaga aatagcaaga gatccgtacg 20640 cagtaataaa tagaaacgta ctactgagat atactaccga tatagagtat aatgatttag 20700 ttactttaat aaccgttaga cataaaattg attctatgaa aactgtgttt caggtattta 20760 acgaatcatc cataaattat actccggttg atgatgatta tggagaacca atcattataa 20820 catcgtatct tcaaaaaggt cataacaagt ttcctgtaaa ttttctatac atagatgtgg 20880 taatatctga cttatttcct agctttgtta gactagatac tacagaaact aatatagtta 20940 atagtgtact acaaacaggc gatggtaaaa agactcttcg tcttcccaaa atgttagaga 21000 cggaaatagt tgtcaagatt ctctaccgtc ctaatatacc attaaaaatt gttagatttt 21060 tccgcaataa catggtaact ggagtagaga tagccgatag atctgttatt tcagtcgctg 21120 attaatcaat tagtagagat gagataagaa cattataata atcaataata tattttatat 21180 cttatatctt gtttagaaaa atgctaatat taaaatagct aacgctagta atccaatcgg 21240 aagccatttg atatctataa tagggtatct aatttcctga ttcagatagc ggacagctat 21300 attctcggta gctactcgtt tggaatcaca aacattattt acatctaatt tactatctgt 21360 aatggaaacg tttcccaatg aaatggtaca atccgataca ttgcattttg ttatattttt 21420 ttttaaagag gctggtaaca acgcatcgct tcgtttacat ggctcgtacc aacaataata 21480 gggtaatctt gtatctattc ctatccgtac tatgctttta tcaggataaa tacatttaca 21540 tcgtatatcg tctttgttag catcacagaa tgcataaatt tgttcgtccg tcatgataaa 21600 aatttaaagt gtaaatataa ctattatttt atagttgtaa taaaaaggga aatttgattg 21660 tatactttcg gttctttaaa agaaactgac ttgataaaaa tggctgtaat ctctaaggtt 21720 acgtatagtc tatatgatca aaaagagatt aatgctacag atattatcat tagtcatgtt 21780 aaaaatgacg acgatatcgg taccgttaaa gatggtagac taggtgctat ggatggggca 21840 ttatgtaaaa cttgtgggaa aacggaattg gaatgtttcg gtcactgggg taaagtaagt 21900 atttataaaa ctcatatagt taagcctgaa tttatttcag aaattattcg tttactgaat 21960 tatatatgta ttcactgcgg attattgcgt tcacgagaac cgtattccga cgatattaa c 22020 ctaaaagagt tatcgggaca cgctcttagg agattaaagg ataaaatatt atccaagaaa 22080 aagtcatgtt ggaacagtga atgtatgcaa ccgtatcaaa aaattacttt ttcaaagaaa 22140 aaggtttgtt tcgtcaacaa gttggatgat attaacgttc ctaattctct catctatcaa 22200 aagttaattt ctattcatga aaagttttgg ccattattag aaattcatca atatccagct 22260 aacttatttt atacagacta ctttcccatc cctccgttga ttattagacc ggctattagt 22320 ttttggatag atagtatacc caaagaaacc aatgaattaa cttacttatt aggtatgatc 22380 gttaagaatt gtaacttgaa tgctgatgaa caggttatcc agaaggcggt aatagaatac 22440 gatgatatta aaattatttc taataacact tccagtatca atttatcata tatcacatcc 22500 ggcaaaaata atatgattag aagttatatc gtcgcccggc gaaaagatca gaccgctaga 22560 tctgtaattg gtcccagtac atctatcacc gttaatgagg taggaatgcc cgcatatatt 22620 agaaatacac ttacagaaaa gatatttgtt aatgccttta cagtggataa agttaaacaa 22680 ctattagcgt caaaccaagt taaattttac tttaataaac gattaaacca attaacaaga 22740 atacgccaag gaaagtttat caaaaataaa atacatttat tgcctggtga ttgggtagaa 22800 gtagctgttc aagaatatac aagtattatt tttggaagac agccgtctct a catagatac 22860 aacgtcatcg cttcatctat cagagctacc gaaggagata ctatcaaaat atctcccgga 22920 attgtcaact ctcaaaatgc tgatttcgac ggagatgaag aatggatgat attggagcaa 22980 aatcctaaag ccgtaattga acaaagtatt cttatgtatc cgacgacgtt actcaaacac 23040 gatattcatg gagcccccgt ttatggatct attcaagatg aaatcgtagc agcgtattca 23100 ttgtttagga tacaagatct ttgtttagat gaagtattga acatcttggg gaaatatgga 23160 agagagttcg atcctaaagg taaatgtaaa ttcagcggta aagatatcta tacttacttg 23220 ataggtgaaa agattaatta tccgggtctc ttaaaggatg gtgaaattat tgcaaacgac 23280 gtagatagta attttgttgt ggctatgagg catctgtcat tggctggact cttatccgat 23340 cataagtcga acgtggaagg tatcaacttt attatcaagt catcttatgt ttttaagaga 23400 tatctatcta tttacggttt tggggtgaca ttcaaagatc tgagaccaaa ttcgacgttc 23460 actaataaat tggaggccat caacgtagaa aaaatagaac ttatcaaaga agcatacgcc 23520 aaatatctca acgatgtaag agacgggaaa atagttccat tatctaaagc tttagaggcg 23580 gactatgtgg aatccatgtt atccaacttg acaaatctta atatccgaga gatagaagaa 23640 catatgagac aaacgctgat agatgatcca gataataacc tcct gaaaat ggccaaagcg 23700 ggttataaag taaatcccac agaactaatg tatattctag gtacttatgg acaacagagg 23760 attgatggtg aaccagcaga gactcgagta ttgggtagag tcttacctta ctatcttcca 23820 gactctaagg atccagaagg aagaggttac attcttaatt ctttaacaaa aggattaacg 23880 ggttctcaat attacttttc gatgctggtt gcaagatctc aatctactga tatcgtctgt 23940 gaaacatcac gtaccggaac actggctaga aaaatcatta aaaagatgga ggatatggtg 24000 gtcgacggat acggacaagt agttataggt aatacgctca tcaagtacgc cgccaattat 24060 accaaaattc taggctcagt atgtaaacct gtagatctta tctatccaga tgagtccatg 24120 acttggtatt tggaaattag tgctctgtgg aataaaataa aacagggatt cgtttactct 24180 cagaaacaga aacttgcaaa aaagacattg gcgccgttta atttcctagt attcgtcaaa 24240 cccaccactg aggataatgc tattaaggtt aaggatctgt acgatatgat tcataacgtc 24300 attgatgatg tgagagagaa atacttcttt acggtatcta atatagattt tatggagtat 24360 atattcttga cgcatcttaa tccttctaga attagaatta caaaagaaac ggctatcact 24420 atctttgaaa agttctatga aaaactcaat tatactctag gtggtggaac tcctattgga 24480 attatttctg cacaggtatt gtctgagaag tttacac aac aagccctgtc cagttttcac 24540 actactgaaa aaagtggtgc cgtcaaacaa aaacttggtt tcaacgagtt taataacttg 24600 actaatttga gtaagaataa gaccgaaatt atcactctgg tatccgatga tatctctaaa 24660 cttcaatctg ttaagattaa tttcgaattt gtatgtttgg gagaattaaa tccaaacatc 24720 actcttcgaa aagaaacaga taggtatgta gtagatataa tagtcaatag attatacatc 24780 aagagagcag aaattaccga attagtcgtc gaatatatga ttgaacgatt catctccttt 24840 agcgtcattg taaaggaatg gggtatggaa acattcattg aggatgagga taatattaga 24900 tttactgtct acctaaattt cgttgaaccg gaagaattga atcttagtaa gtttatgatg 24960 gttcttccgg gtgccgccaa caagggcaag attagtaaat tcaagattcc tatctctgat 25020 tatacgggat atgacgactt caatcaaaca aaaaagctca ataagatgac tgtagaactc 25080 atgaatctaa aagaattggg ttctttcgat ttggaaaacg tcaacgtgta tcctggagta 25140 tggaatacat acgatatctt cggtatcgag gccgctcgtg aatacttgtg cgaagccatg 25200 ttaaacacct atggagaagg gttcgattat ctgtatcagc cttgtgatct tctcgctagt 25260 ttactatgtg ctagttacga accagaatca gtgaataaat tcaagttcgg cgcagctagt 25320 actcttaaga gagctacgtt cggagacaat aaagcattgt taaacgcggc tcttcataaa 25380 aagtcagaac ctattaacga taatagtagc tgccactttt ttagcaaggt ccctaatata 25440 ggaactggat attacaaata ctttatcgac ttgggtcttc tcatgagaat ggaaaggaaa 25500 ctatctgata agatatcttc tcaaaagatc aaggaaatgg aagaaacaga agacttttaa 25560 ttcttatcaa taacatattt ttctatgatc tgtcttttaa acgatggatt ttccacaaat 25620 gcgcctctca agtccctcat agaatgatac acgtataaaa aatatagcat aggcaatgac 25680 tccttatttt tagacattag atatgccaaa atcatagccc cgcttctatt tactcccgca 25740 gcacaatgaa ccaacacggg ctcgtttcgt tgatcacatt tagataaaaa ggcggttacg 25800 tcgtcaaaat atttactaat atcggtagtt gtatcatcta ccaacggtat atgaataata 25860 ttaatattag agttaggtaa tgtatattta tccatcgtca aatttaaaac atatttgaac 25920 ttaacttcag atgatggtgc atccatagca tttttataat ttcccaaata cacattattg 25980 gttactcttg tcattatagt gggagatttg gctttgtgca tatctccagt tgaacgtagt 26040 agtaagtatt tatacaaact tttcttatcc atttataacg tacaaatgga taaaactact 26100 ttatcggtaa acgcgtgtaa tttagaatac gttagagaaa aggctatagt aggcgtacaa 26160 gcagccaaaa catcaacact ta tattcttt gttattatat tggcaattag tgcgctatta 26220 ctctggtttc agacgtctga taatccagtc tttaatgaat taacgagata tatgcgaatt 26280 aaaaatacgg ttaacgattg gaaatcatta acggatagca aaacaaaatt agaaagtgat 26340 agaggtagac ttctagccgc tggtaaggat gatatattcg aattcaaatg tgtggatttc 26400 ggcgcctatt ttatagctat gcgattggat aagaaaacat atctgccgca agctattagg 26460 cgaggtactg gagacgcgtg gatggttaaa aaggcggcaa aggtcgatcc atctgctcaa 26520 caattttgtc agtatttgat aaaacacaag tctaataatg ttattacttg tggtaatgag 26580 atgttaaatg aattaggtta tagcggttat tttatgtcac cgcattggtg ttccgatttt 26640 agtaatatgg aatagtgtta gataaatgcg gtaacgaatg ttcctgtaag gaaccataac 26700 agcttagatt taacgttaaa gatgagcata aacataataa acaaaattac aatcaaacct 26760 ataacattaa tatcaaacaa tccaaaaaat gaaatcagtg gagtagtaaa cgcgtacata 26820 actcctggat aacgtttagc agctgccgtt cctattctag accaaaaatt cggtttcatg 26880 ttttcgaaac ggtattctgc aacaagtcga ggatcgtgtt ctacatattt ggcggcgtta 26940 tccagtatct gcctattgat cttcatttcg ttttcgattc tggctatttc aaaataaaat 27000 cccgatgata gacct ccaga ctttataatt tcatctacga tgttcagcgc cgtagtaact 27060 ctaataatat aggctgataa gctaacatca taccctcctg tatatgtgaa tatggcatga 27120 tttttgtcca ttacaagctc ggttttaact ttattgcctg taataatttc tctcatctgt 27180 aggatatcta tttttttgtc atgcattgcc ttcaagacgg gacgaagaaa cgtaatatcc 27240 tcaataacgt tatcgttttc tacaataact acatattcta cctttttatt ttctaactcg 27300 gtaaaaaaat tagaatccca tagggctaaa tgtctagcga tatttctttt cgtttcctct 27360 gtacacatag tgttacaaaa ccctgaaaag aagtgagtat acttgtcatc atttctaatg 27420 tttcctccag tccactgtat aaacgcataa tccttgtaat gatctggatc atccttgact 27480 accacaacat ttcttttttc tggcataact tcattgtcct ttacatcatc gaacttctga 27540 tcattaatat gctcatgaac attaggaaat gtttctgatg gaggtctatc aataactggc 27600 acaacaataa caggagtttt caccgccgcc atttagttat tgaaattaat catatacaac 27660 tctttaatac gagttatatt ttcgtctatc cattgtttca catttacata tttcgacaaa 27720 aagatataaa atgcgtattc caatgcttct ctgtttaatg aattactaaa atatacaaac 27780 acgtcactgt ctggcaataa atgatatctt agaatattgt aacaatttat tttgtattgc 27840 acatgttcgt gatctatgag ttcttcttcg aatggcatag gatctccgaa tctgaaaacg 27900 tataaatagg agttagaata ataatatttg agagtattgg taatatataa actctttagc 27960 ggtataatta gtttttttct ctcgatttct atttttagat gtgatggaaa aatgactaat 28020 tttgtagcat tagtatcatg aactctaatc gagatcttaa tatcttcgtc acacgttag t 28080 tctttgaagt ttttaagaga tgcatcagtt ggttcgaccg atggagtagg tgcaacaatt 28140 ttttgttcga tgtatgtatg tactggagcc attgtcttaa ctataatggt gcttgtatcg 28200 aaaaacttta atgcagataa tggaagctct tcgccgcgac tttctacatc gtaattgggt 28260 tctaacgccg atctctgaat ggatactagt tttctaagtt ctaatgtgat tctctgaaaa 28320 tgtaaatcca attcctccgg cattatagat gtgtatacat cggtaaataa aactatagta 28380 tccaacgatc ccttctcgca aattctagtc ttaaccaaaa aatcgtatat aaccacggag 28440 atggcgtatt taagagtgga ttcttctacc gttttgttct tggatttcat ataagaaact 28500 ataaagtccg cactactgtt aagaatgatt actaacgcaa ctatatagtt taaattaagc 28560 atcttggaaa cataaaataa ctctgtagac gatacttgac tttcgaataa gtttgcagac 28620 aaacgaagaa agaacagacc tctcttaatt tcagaagaaa actttttttc gtattcctga 28680 cgtctagagt ttatatcaat aagaaagtta agaattagtc ggttaatgtt gtatttcatt 28740 acccaagttt gagatttcat aatattatca aaagacatga taatattaaa gataaagcgc 28800 tgactatgaa cgaaatagct atatggttcg ctcaagaata tagtcttgtt aaacgtggaa 28860 acgataactg tatttttaat cacgtcagcg gcatctaaat taaatatagg t atatttatt 28920 ccacacactc tacaatatgc cacaccatct tcataataaa taaattcgtt agcaaaatta 28980 ttaattttag tgaaatagtt agcgtcaact ttcatagctt ccttcaatct aatttgatgc 29040 tcacacggtg cgaattccac tctaacatcc cttttccatg cctcaggttc atcgatctct 29100 ataatatcta gttttttgcg tttcacaaac acaggctcgt ctctcgcgat gagatctgta 29160 tagtaactat gtaaatgata actagataga aagatgtagc tatatagatg acgatccttt 29220 aagagaggta tgatgacttt accccaatca gatagactgt tgttatggtc ttcggaaaaa 29280 gaatttttat aaatttttcc agtattttcc aaatatacgt acttaacatc taaaaaatcc 29340 ttaatgataa taggaatgga taatccgtct attttataaa gaaatacata tcgcacatta 29400 tacttttttt tggaaatggg aataccgatg tgtctacata aatatgcaaa gtctaaatat 29460 tttttagaga atcttagttg gtccaaattc ttttccaagt acggtaatag atttttcata 29520 ttgaacggta tcttcttaat ctctggttct agttccgcat taaatgatga aactaagtca 29580 ctatttttat aactaacgat tacatcacct ctaacatcat catttaccag aatactgatc 29640 ttcttttgtc gtaaatacat gtctaatgtg ttaaaaaaaa gatcatacaa gttatacgtc 29700 atttcatctg tggtattctt gtcattgaag gataaactcg tact aatctc ttctttaaca 29760 gcctgttcaa atttatatcc tatatacgaa aaaatagcaa ccagtgtttg atcatccgcg 29820 tcaatattct gttctatcgt agtgtataac aatcgtatat cttcttctgt gatagtcgat 29880 acgttataaa ggttgataac gaaaatattt ttatttcgtg agataaagtc atcgtaggat 29940 tttggactta tattcgcgtc tagtagatat gcttttattt ttggaatgat ctcaattaga 30000 atagtctctt tagagtccat ttaaagttac aaacaactag gaaattggtt tatgatgtat 30060 aattttttta gtttttatag attctttatt ctatacttaa aaaatgaaaa taaatacaaa 30120 ggttcttgag ggttgtgtta aattgaaagc gagaaataat cataaattat ttcattatcg 30180 cgatatccgt taagtttgta tcgtaatggc gtggtcaatt acaaataaag cggatactag 30240 tagcttcaca aagatggctg aaatcagagc tcatctaaaa aatagcgctg aaaataaaga 30300 taaaaacgag gatattttcc cggaagatgt aataattcca tctactaagc ccaaaaccaa 30360 acgagccact actcctcgta aaccagcggc tactaaaaga tcaaccaaaa aggaggaagt 30420 ggaagaagaa gtagttatag aggaatatca tcaaacaact gaaaaaaatt ctccatctcc 30480 tggagtcagc gacattgtag aaagcgtggc tgctgtagag ctcgatgata gcgacgggga 30540 tgatgaacct atggtacaag ttgaagctgg taaagta aat catagtgcta gaagcgatct 30600 ttctgaccta aaggtggcta ccgacaatat cgttaaagat cttaagaaaa ttattactag 30660 aatctctgca gtatcgacgg ttctagagga tgttcaagca gctggtatct ctagacaatt 30720 tacttctatg actaaagcta ttacaacact atctgatcta gtcaccgagg gaaaatctaa 30780 agttgttcgt aaaaaagtta aaacttgtaa gaagtaaatg cgtgcacttt tttataaaga 30840 tggtaaactc tttaccgata ataatttttt aaatcctgta tcagacgata atccagcgta 30900 tgaggttttg caacatgtta aaattcctac tcatttaaca gatgtagtag tatatgaaca 30960 aacgtgggag gaggcgttaa ctagattaat ttttgtggga agtgattcaa aaggacgtag 31020 acaatacttt tacggaaaaa tgcatgtaca gaatcgcaac gctaaaagag atcgtatttt 31080 tgttagagta tataacgtta tgaaacgaat taattgtttt ataaacaaaa atataaagaa 31140 atcgtccaca gattccaatt atcagttggc ggtttttatg ttaatggaaa ctatgttttt 31200 tattagattt ggtaaaatga aatatcttaa ggagaatgaa acagtagggt tattaacact 31260 aaaaaataaa cacatagaaa taagtcccga tgaaatagtt atcaagtttg taggaaagga 31320 caaagtttca catgaatttg ttgttcataa gtctaataga ctatataaac cgctattgaa 31380 actgacggat gattctagtc ccgaagaatt tctgttcaac aaactaagtg aacgaaaggt 31440 atacgaatgt atcaaacagt ttggtattag aatcaaggat ctccgaacgt atggagtcaa 31500 ttatacgttt ttatataatt tttggacaaa tgtaaagtcc atatctcctc ttccgtcacc 31560 aaaaaagtta atagcgttaa ctatcaaaca aactgctgaa gtggtaggtc atactccatc 31620 aatttcaaaa agagcttata tggcaacgac tattttagaa atggtaaagg ataaaaattt 31680 tttagatgta gtatctaaaa ctacgttcga tgaattccta tctatagtcg tagatcacgt 31740 taaatcatct acggatggat gatatagatc tttacacaaa taattacaag accgataaat 31800 ggaaatggat aagcgtatga aatctctcgc aatgacagct ttcttcggag agctaaacac 31860 attagatatt atggcattga taatgtctat atttaaacgc catccaaaca ataccatttt 31920 ttcagtggat aaggatggtc agtttatgat tgatttcgaa tacgataatt ataaggcttc 31980 tcaatatttg gatctgaccc tcactccgat atctggagat gaatgcaaga ctcacgcatc 32040 gagtatagcc gaacaattgg cgtgtgtgga tattattaaa gaggatatta gcgaatatat 32100 caaaactact ccccgtctta aacgatttat aaaaaaatac cgcaatagat cagatactcg 32160 tatcagtcga gatacagaaa agcttaaaat agctctagct aaaggcatag attacgaata 32220 tataaaagac gcttgttaat aa gtaaatga aaaaaaacta gtcgtttata ataaaacaca 32280 atatggatgc caacatagta tcatcttcta ctattgcaac gtatatagac gctttagcga 32340 agaatgcttc agaattagaa cagaggtcta ccgcatacga aataaataat gaattggaac 32400 tagtatttat taagccgcca ttaattactt tgacaaatgt agtgaatatc tctacgattc 32460 aggaatcgtt tattcgattt accgttacta ataaggaagg tgttaaaatt agaactaaga 32520 ttccattatc taaggtacat ggtctagatg taaaaaatgt acagttagta gatgctatag 32580 ataacatagt ttgggaaaag aaatcattag tgacggaaaa tcgtcttcac aaagaatgct 32640 tgttgagact atcgacagag gaacgtcata tatttttgga ttacaagaaa tatggatcct 32700 ctatccgact agaattagtc aatcttattc aagcaaaaac aaaaaacttt acgatagact 32760 ttaagctaaa atattttcta ggatccggtg cccagtctaa aagttcttta ttacacgcta 32820 ttaatcatcc aaagtcaagg cctaatacat ctctggaaat agaattcaca cctagagaca 32880 atgaaaaagt tccatatgat gaactaataa aggaattgac gactctatca cgtcatatat 32940 ttatggcttc tccagagaat gtaattcttt ctccgcctat taacgcgcct ataaaaacct 33000 ttatgttgcc taaacaagat atagtaggtt tggatctgga aaatctatat gccgtaacta 33060 agactgacgg aattc ctata actatcagag ttacatcaaa agggttgtat tgttatttta 33120 cacatcttgg ttatattatt agatatcctg ttaagagaat aatagattcc gaagtagtag 33180 tctttggtga ggcagttaag gataagaact ggaccgtata tctcattaag ctaatagagc 33240 ctgtgaatgc aatcaatgat agactagaag aaagtaagta tgttgaatct aaactagtgg 33300 atatttgtga tcggatagta ttcaagtcaa agaaatacga aggtccgttt actacaacta 33360 gtgaagtcgt cgatatgtta tctacatatt taccaaagca accagaaggt gttattctgt 33420 tctattcaaa gggacctaaa tctaacattg attttaaaat taaaaaggaa aatactatag 33480 accaaactgc aaatgtagta tttaggtaca tgtccagtga accaattatc tttggagaat 33540 cgtctatctt tgtagagtat aagaaattta gcaacgataa aggctttcct aaagaatatg 33600 gttctggtaa gattgtgtta tataacggcg ttaattatct aaataatatc tattgtttgg 33660 aatatattaa tacacataat gaagtgggta ttaagtccgt ggttgtacct attaagttta 33720 tagcagaatt cttagttaat ggagaaatac ttaaacctag aattgataaa accatgaaat 33780 atattaactc agaagattat tatggaaatc aacataatat catagtcgaa catttaagag 33840 atcaaagcat caaaatagga gatatcttta acgaggataa actatcggat gtgggacatc 33900 aatacgcc aa taatgataaa tttagattaa atccagaagt tagttatttt acgaataaac 33960 gaactagagg accgttggga attttatcaa actacgtcaa gactcttctt atttctatgt 34020 attgttccaa aacattttta gacgattcca acaaacgaaa ggtattggcg attgattttg 34080 gaaacggtgc ggacctggaa aaatactttt atggagagat tgcgttattg gtagcgacgg 34140 atccggatgc tgatgctata gctagaggaa atgaaagata caacaaatta aactctggaa 34200 ttaaaaccaa gtactacaaa tttgactaca ttcaggaaac tattcgatcc gatacatttg 34260 tctctagtgt cagagaagta ttctattttg gaaagtttaa tatcatcgac tggcagtttg 34320 ctatccatta ttcttttcat ccgagacatt atgctaccgt catgaataac ttatccgaac 34380 taactgcttc tggaggcaag gtattaatca ctaccatgga cggagacaaa ttatcaaaat 34440 taacagataa aaagactttt ataattcata agaatttacc tagtagcgaa aactatatgt 34500 ctgtagaaaa aatagctgat gatagaatag tggtatataa tccatcaaca atgtctactc 34560 caatgactga atacattatc aaaaagaacg atatagtcag agtgtttaac gaatacggat 34620 ttgttcttgt agataacgtt gatttcgcta caattataga acgaagtaaa aagtttatta 34680 atggcgcatc tacaatggaa gatagaccgt ctacaaaaaa ctttttcgaa ctaaatagag 34740 gagccattaa atgtgaaggt ttagatgtcg aagacttact tagttactat gttgtttatg 34800 tcttttctaa gcggtaaata ataatatggt atgggttctg atatccccgt tctaaatgca 34860 ttaaataatt ccaatagagc gatttttgtt cctataggac cttccaactg tggatactct 34920 gtattgttaa tagatatatt aatacttttg tcgggtaaca gaggttctac gtcttctaaa 34980 aataaaagtt tgataacatc tggcctgttc ataaataaaa acttggcgat tctatatata 35040 ctcttattat caaatctagc cattgtctta tagatgtgag ctactgtagg tgtaccattt 35100 gattttcttt ctaatactat atatttctct cgaagaagtt cttgcacatc atctgggaat 35160 aaaatactac tgttgagtaa atcagttatt ttttttatat cgatattgat ggacattttt 35220 atagttaagg ataataagta tcccaaagtc gataacgacg ataacgaagt atttatactt 35280 ttaggaaatc acaatgactt tatcagatca aaattaacaa aattaaagga gcatgtattt 35340 ttttctgaat atattgtgac tccagataca tatggatctt tatgcgtcga attaaatggg 35400 tctagttttc agcacggtgg tagatatata gaggtggagg aatttataga tgctggaaga 35460 caagttagat ggtgttctac atccaatcat atatctgaag atatgcacac tgataaattt 35520 gtcatttatg atatttatac gtttgattcg ttcaagaata aacgattggt atttgtaca g 35580 gtgcctccat cattaggaga tgatagctat ttgactaatc cgttattgtc tccgtattat 35640 cgtaattcag tagccagaca aatggtcaat gatatgattt ttaatcaaga ttcattttta 35700 aaatatttat tagaacatct gattagaagc cactatagag tttctaaaca tataacaata 35760 gttagataca aggataccga agaattaaat ctaacgagaa tatgttataa tagagataag 35820 tttaaggcgt ttgtattcgc ttggtttaac ggcgtttcgg aaaatgaaaa ggtactagat 35880 acgtataaaa aggtatctaa tttgatataa tgaattcagt gactgtatca cacgcgccat 35940 atactattac ttatcacgat gattgggaac cagtaatgag tcaattggta gagttttata 36000 acgaagtagc cagttggctg ctacgagacg agacgtcgcc tattcctgat aagttcttta 36060 tacagttgaa acaaccgctt agaaataaac gagtatgtgt gtgtggtata gatccgtatc 36120 cgaaagatgg aactggtgta ccgttcgaat caccaaattt tacaaaaaaa tcaattaagg 36180 agatagcttc atctatatct agattaaccg gagtaattga ttataaaggt tataacctta 36240 atataataga cggggttata ccctggaatt attacttaag ttgtaaatta ggagaaacaa 36300 aaagtcacgc gatctactgg gataagattt ccaagttact gctgcagcat ataactaaac 36360 acgttagtgt tctttattgt ttgggtaaaa cagatttctc gaatatacgg g caaagttag 36420 aatccccggt aactaccata gtcggatatc atccagcggc tagagaccgc caattcgaga 36480 aagatagatc atttgaaatt atcaacgttt tactggaatt agacaacaag gcacctataa 36540 attgggctca agggtttatt tattaatgct ttagtgaaat tttaacttgt gttctaaatg 36600 gatgcaacta ttagaggtaa tgatgttatc tttgttctta agactatagg tgtcccgtca 36660 gcgtgcagac aaaatgaaga tccaagattt gtagaagcat ttaaatgcga cgagttagaa 36720 agatatattg agaataatcc agaatgtaca ctattcgaaa gtcttaggga tgaggaagca 36780 tactctatag tcagaatttt catggatgta gatttagacg cgtgtctaga cgaaatagat 36840 tatttaacgg ctattcaaga ttttattatc gaggtgtcaa actgtgtagc tagattcgcg 36900 tttacagaat gcggtgccat tcatgaaaat gtaataaaat ccatgagatc taatttttca 36960 ttgactaagt ctacaaatag agataaaaca agttttcata ttatcttttt agacacgtat 37020 accactatgg atacattgat agctatgaaa cgaacactat tagaattaag tagatcatct 37080 gaaaatccac taaccagatc gatagacact gccgtatata ggagaaaaac aactcttcgg 37140 gttgtaggta ctaggaaaaa tccaaattgc gacactattc atgtaatgca accaccgcat 37200 gataatatag aagattacct attcacttac gtggatatga acaa caatag ttattacttt 37260 tctctacaac gacgattgga ggatttagtt cctgataagt tatgggaacc agggtttatt 37320 tcattcgaag acgctataaa aagagtttca aaaatattca ttaattctat aataaacttt 37380 aatgatctcg atgaaaataa ttttacaacg gtaccactgg tcatagatta cgtaacacct 37440 tgtgcattat gtaaaaaacg atcgcataaa catccgcatc aactatcgtt ggaaaatggt 37500 gctattagaa tttacaaaac tggtaatcca catagttgta aagttaaaat tgttccgttg 37560 gatggtaata aactgtttaa tattgcacaa agaattttag acactaactc tgttttatta 37620 accgaacgag gagaccatat agtttggatt aataattcat ggaaatttaa cagcgaagaa 37680 cccttgataa caaaactaat tctgtcaata agacatcaac tacctaagga atattcaagc 37740 gaattactct gtccgaggaa acgaaagact gtagaagcta acatacgaga catgttaata 37800 gattcagtgg agaccgatac ctatccggat aaacttccgt ttaaaaatgg tgtattggac 37860 ctggtagacg gaatgtttta ctctggagat gatgctaaaa aatatacgtg tactgtatca 37920 accggattta aatttgacga tacaaagttc gtcgaagaca gtccagaaat ggaagagtta 37980 atgaatatca ttaacgatat ccaaccatta acggatgaaa ataagaaaaa tagagagttg 38040 tacgaaaaaa ctttatctag ttgtttatgc ggtgcta cca aaggatgttt aacattcttt 38100 tttggagaaa ctgcaactgg aaagtcgaca accaaacgtt tgttaaagtc tgctatcggt 38160 gacctgtttg ttgagacggg tcaaacaatt ttaacagatg tattggataa aggacctaat 38220 ccatttatcg ctaacatgca tttgaaaaga tctgtattct gtagcgaact acctgatttt 38280 gcctgtagtg gatcaaagaa aattagatct gacaatatta aaaagttgac agaaccttgt 38340 gtcattggaa gaccgtgttt ctccaataaa attaataata gaaaccatgc gacaatcatt 38400 atcgatacta attacaaacc tgtctttgat aggatagata acgcattaat gagaagaatt 38460 gccgtcgtgc gattcagaac acacttttct caaccttctg gtagagaggc tgctgaaaat 38520 aatgacgcgt acgataaagt caaactatta gacgaggggt tagatggtaa aatacaaaat 38580 aatagatata gattcgcatt tctatacttg ttggtgaaat ggtacaaaaa atatcatgtt 38640 cctattatga aactatatcc tacaccggaa gagattccgg actttgcatt ctatctcaaa 38700 ataggtactc tgttagtatc tagctctgta aagcatattc cattaatgac ggacctctcc 38760 aaaaagggat atatattgta cgataatgtg gttactcttc cgttgactac tttccaacag 38820 aaaatatcca agtattttaa ttctagacta tttggacacg atatagagag cttcatcaat 38880 agacataaga aatttgccaa tgttagtgat gaatatctgc aatatatatt catagaggat 38940 atttcatctc cgtaaatata tgctcatata tttatagaag atatcacata tctaaatgaa 39000 taccggaatc atagatttat ttgataatca tgttgatagt ataccaacta tattacctca 39060 tcagttagct actctagatt atctagttag aactatcata gatgagaaca gaagcgtgtt 39120 attgttccat attatgggat caggtaaaac aataatcgct ttgttgttcg ccttggtagc 39180 ttccagattt aaaaaggttt acattctagt gcctaatatt aacattttga aaatttttaa 39240 ttataatatg ggtgtagcta tgaacttgtt taatgacgaa ttcatagctg agaatatctt 39300 tattcattcc acaacaagtt tttattctct taattataac gataacgtca ttaattataa 39360 cggattatct cgctacaata actctatttt tatcgttgat gaggcacata atatctttgg 39420 gaataatact ggagaactta tgaccgtgat aaaaaataaa aacaagattc cttttttact 39480 attgtctgga tctcccatta ctaacacacc taatactctg ggtcatatta tagatttaat 39540 gtccgaagag acgatagatt ttggtgaaat tattagtcgt ggtaagaaag taattcagac 39600 acttcttaac gaacgaggtg tgaatgtact taaggatttg cttaaaggaa gaatatcata 39660 ttacgaaatg cctgataaag atctaccaac gataagatat cacggacgta agtttctaga 39720 tactagagta gtatattgtc ac atgtctaa acttcaagag agagattata tgattactag 39780 acgacagcta tgttatcatg aaatgtttga taaaaatatg tataacgtgt caatggcagt 39840 attgggacaa cttaatctga tgaataattt agatacttta tttcaggaac aggataagga 39900 attgtaccca aatctgaaaa taaataatgg cgtgttatac ggagaagaat tggtaacgtt 39960 aaacattagt tccaaattta aatactttat taatcggata cagacactca acggaaaaca 40020 ttttatatac ttttctaatt ctacatatgg cggattggta attaaatata tcatgctcag 40080 taatggatat tctgaatata atggttctca gggaactaat ccacatatga taaacggcaa 40140 accaaaaaca tttgctatcg ttactagtaa aatgaaatcg tctttagagg atctattaga 40200 tgtgtataat tctcctgaaa acgatgatgg cagtcaattg atgtttttgt tttcgtcaaa 40260 cattatgtcc gaatcctata ctctgaaaga ggtaaggcat atttggttta tgactatccc 40320 agatactttt tctcaataca accaaattct tggacgatct attagaaaat tctcttacgc 40380 cgatatttct gaaccagtta atgtatatct tttagccgcc gtatattccg atttcaatga 40440 cgaagtgacg tcattaaacg attacacaca ggatgaatta attaatgttt taccatttga 40500 catcaaaaag ctgttgtatc taaaatttaa gactaaagaa acgaatagaa tatactctat 40560 tcttcaagag atgtc tgaaa cgtattctct tccaccacat ccatcaattg taaaagtttt 40620 attgggagaa ttggtcagac aattttttta taataattct cgtattaagt ataacgatac 40680 caagttactt aaaatggtta catcagttat aaaaaataaa gaagacgcta ggaattacat 40740 agatgatatt gtaaacggtc acttctttgt atcgaataaa gtatttgata aatctctttt 40800 atacaaatac gaaaacgata ttattacagt accgtttaga ctttcctacg aaccatttgt 40860 ttggggagtt aactttcgta aagaatataa cgtggtatct tctccataaa actgatgaga 40920 tatataaaga aataaatgtc gagctttgtt accaatggat accttccagt tacattggag 40980 ccacacgagc tgacgttaga cataaaaact aatattagga atgccgtata taagacgtat 41040 ctccatagag aaattagtgg taaaatggcc aagaaaatag aaattcgtga agacgtggaa 41100 ttacctctcg gcgaaatagt taataattct gtagttataa acgttccgtg tgtaataacc 41160 tacgcgtatt atcacgttgg ggatatagtc agaggaacat taaacatcga agatgaatca 41220 aatgtaacta ttcaatgtgg agatttaatc tgtaaactaa gtagagattc gggtactgta 41280 tcatttagcg attcaaagta ctgctttttt cgaaatggta atgcgtatga caatggcagc 41340 gaagtcactg ccgttctaat ggaggctcaa caaggtatcg aatctagttt tgtttttctc 41400 gcgaatatcg ttgactcata aaaaagagaa tagcggtaag tataaacacg aatactatgg 41460 caataattgc gaatgtttta ttcccttcga tatatttttg ataatatgaa aaacatgtct 41520 ctctcaaatc ggacaaccat ctcataaaat agttctcgcg cgctggagag gtagttgctg 41580 ctcgtataat ctccccagaa taatatactt gcgtgtcgtc gttcaattta tacggattt c 41640 tatagttctc tgttatataa tgcggttttc catcatgatt agacgacgac aatagtgttc 41700 taaatttaga tagttgatca gaatgaatgt ttattggcgt tggaaaaatt atccatacag 41760 cgtctgcaga gtggttgata gttgttccta gatatgtaaa ataatccaac ttactaggca 41820 gcaaattgtc tagataaaat actgaatcaa acggtgcaga cgtattggtg gatctaatgg 41880 aatccaattg attaactatc ttttgaaaat atacattttt atgatccgat acttgtaaga 41940 atatagaaat aatgataagt ccatcatcgt gtttttttgc ctcttcataa gaactatatt 42000 ttttcttatt ccaatgaaca agattaatct ctccagagta tttgtacaca tctatcaagt 42060 gattggatcc ataatcgtct tcctttcccc aatatatacg tagtgatgat aacacatatt 42120 cattggggag aaaccctcca cttatatatc ctcctttaaa attaatcctt actagttttc 42180 cagtgttctg gatagtggtt ggtttcgact cattataatg tatgtctaac ggcttcaatc 42240 gcgcgttaga aattgctttt ttagtttcta tattaatagg agatagttgt tgcggcatag 42300 taaaaatgaa atgataactg tttaaaaata gctcttagta tgggaattac aatggatgag 42360 gaagtgatat ttgaaactcc tagagaatta atatctatta aacgaataaa agatattcca 42420 agatcaaaag acacgcatgt gtttgctgcg tgtataacaa gtgacggata t ccgttaata 42480 ggagctagaa gaacttcatt cgcattccaa gcgatattat ctcaacaaaa ttcagattct 42540 atctttagag tatccactaa actattacgg tttatgtact acaatgaact aagagaaatc 42600 tttagacggt tgagaaaagg ttctatcaac gatatcgatc ctcactttga agagttaata 42660 ttattgggtg gtaaactaga taaaaaggaa tctattaaag attgtttaag aagagaatta 42720 aaagaggaaa gtgatgaacg tataacagta aaagaatttg gaaatgtaat tctaaaactt 42780 acaacacggg ataaattatt taataaagta tatataagtt attgcatggc gtgttttatt 42840 aatcaatcgt tggaggattt atcgcatact agtatttaca atgtagaaat tagaaagatt 42900 aaatcattaa atgattgtat taacgacgat aaatacgaat atctgtctta tatttataat 42960 atgctagtta atagtaaatg aacttttaca gatctagtat aattagtcag attattaagt 43020 ataatagacg actagctaag tctattattt gcgaggatga ctctcaaatt attacactca 43080 cggcattcgt taaccaatgc ctatggtgtc ataaacgagt atccgtgtcc gctattttat 43140 taactactga taacaaaata ttagtatgta acagacgaga tagttttctc tattctgaaa 43200 taattagaac tagaaacatg tctagaaaga aacgattatt tctgaattat tccaattatt 43260 tgtccaaaca ggaaagaagt atactatcgt catttttttc tcta gatcca gctactactg 43320 ataatgatag aatagatgct atttatccgg gtggcatacc caaaaggggt gagaatgttc 43380 cagagtgttt atccagggaa attaaagaag aagttaatat agacaattct tttgtattca 43440 tagacactcg gttttttatt catggcatca tagaagatac cattattaat aaattttttg 43500 aggtaatctt ctttgtcgga agaatatctt taacgagtga tcaaatcatt gatacattta 43560 aaagtaatca tgaaatcaag gatctaatat ttttagatcc gaattcaggt aatggactcc 43620 aatacgaaat tgcaaaatat gctctagata ctgcaaaact caaatgttat ggccatagag 43680 gatgttatta cgaatcatta aaaaaattaa ctgaggatga ttgattagaa aatataaatt 43740 aatttaccat cgtgtatttt tataacggga ttgtccggca tatcatgtag atagttaccg 43800 tctacatcgt atactcgacc atctacgcct ttaaatcctc tatttattga cattaatcta 43860 ttagaattgg aataccaaat attagtaccc tcaattagtt tattggtaat atttttttta 43920 gacgatagat cgatggctct tgaaaccaag gttttccaac cggactcatt gtcgatcggt 43980 gagaagtctt tttcattagc atgaatccat tctaatgatg tatgtttaaa cactctaaac 44040 aattggacaa attcttttga tttgctttga atgatttcaa ataggtcttc gtctacagta 44100 ggcataccat tagataatct agccattata aagtgca cgt ttacatatct acgttctgga 44160 ggagtaagaa cgtgactatt gagacgaatg gctcttccta ctatctgacg aagagacgcc 44220 tcgttccatg tcatatctaa aatgaagata tcattaattg agaaaaaact aataccctcg 44280 cctccactag aagagaatac gcatgtttta atgcattctc cgttagtgtt tgattcttgg 44340 ttaaactcag ccaccgcctt gattctagta tcttttgttc tagatgagaa ctctatatta 44400 gagataccaa agactttgaa atatagtaat aagatttcta ttcctgactg attaacaaat 44460 ggttcaaaga ctagacattt accatgggat gctaatattc ccaaacatac atctataaat 44520 ttgacgcttt tctcttttaa ttcagtaaat agagagatat cagccgcact agcatcccct 44580 ttcaatagtt ctcccttttt aaaggtatct aatgcggatt tagaaaactc tctatctctt 44640 aatgaatttt taaaatcatt atatagtgtt gctatctctt gcgcgtattc gcccggatca 44700 cgattttgtc tttcaggaaa gctatcgaac gtaaacgtag tagccatacg tctcagaatt 44760 ctaaatgatg atatacctgt ttttatttca gcgagtttag ccttttgata aatttcttct 44820 tgctttttcg acatattaac gtatcgcatt aatactgttt tcttagcgaa tgatgcagac 44880 ccttctacgt catcaaaaat agaaaactcg ttattaacta tgtacgaaca taggcctcct 44940 agtttggaga ctaattcttt ctcatcaact agacgtttat tctcaaatag cgattggtgt 45000 tgtaaggatc ctggtcgtag taagttaacc aacatggtga attcttgcac actattaacg 45060 ataggtgtag ccgataaaca aatcatctta tggtttttta atgcgatggt cttagataaa 45120 aaattatata ctgaacgagt aggacggatc ttaccatctt ctttgattaa tgatttagaa 45180 atgaagttat gacattcatc aataatgacg catattctac tcttggaatt aatagttttg 45240 atattagtaa aaaatttatt tctaaaattt tgatcatcgt aattaataaa aatacaatcc 45300 ttcgttatct ctggagcgta tctgagtata gtgttcatcc aaggatcttc tatcaaagcc 45360 tttttcacca ataagataat agcccaattc gtataaatat ccttaagatg tttgagaata 45420 tatacagtag tcattgtttt accaacaccc gtttcatgga acaataaaag agaatgcata 45480 ctgtctaatc ctaagaaaac tcttgctaca aaatgttgat aatccttgag gcgtactacg 45540 tctgttccca tcatttcaac aggcatatta gtagttctgc gcaatgcata atcgatatag 45600 gccgcgtgtg atttactcat ttatgagtga taagtaataa ctatgtttta aaaatcacag 45660 cagtagttta actagtcttc tctgatgttt gttttcgata ctttttgaat cagaagtcat 45720 actagaataa agcaacgagt gaacgtaata gagagcttcg tatactctat tcgaaaactc 45780 taagaactta ttaatgaatt cc gtatccac tggattgttt aaaatactaa attgaacact 45840 gttcacatcc ttccaagaag aagacttagt gacggactta acatgagaca taaataaatc 45900 caaatttttt ttacaaacat cactagccac cataatggcg ctatctttca accagctatc 45960 gcttacgcat tttagcagtc taacattttt aaagagacta caatatattc tcatagtatc 46020 gattacacct ctaccgaata aagttggaag tttaataata caatattttt cgtttacaaa 46080 atcaaataat ggtcgaaaca cgtcgaaggt taacatctta taatcgctaa tgtatagatt 46140 gttttcagtg agatgattat tagatttaat agcatctcgt tcacgtttga acagtttatt 46200 gtgtgcgctg aggtcggcaa ctacggcgtc cgctttagta ctcctcccat aatactttac 46260 gctattaatc tttaaaattt catagacttt atctagatcg ctttctggta acatgatatc 46320 atgtgtaaaa agttttaaca tgtcggtcgg cattctattt agatcattaa ctctagaaat 46380 ctgaagaaag taattagctc cgtattccag actaggtaat gggcttttac ctaaagacaa 46440 gttaagttct ggcaatgttt cataaaatgg aagaaggaca tgcgttccct cccggatatt 46500 ttttacaatt tcatccattt acaactctat agtttgtttt cattattatt agttattatc 46560 tcccataatc ttggtaatac ttaccccttg atcgtaagat accttataca ggtcattaca 46620 tacaactacc aattg ttttt gtacataata gattggatgg ttgacatcca tggtggaata 46680 aactactcga acagatagtt tatctttccc cctagataca ttggccgtaa tagttgtcgg 46740 cctaaagaat atctttggtg taaagttaaa agttagggtt cttgttccat tattgctttt 46800 tgtcagtagt tcattataaa ttctcgagat gggtccgttc tctgaatata gaacatcatt 46860 tccaaatcta acttctagtc tagaaataat atcggtctta ttcttaaaat ctattccctt 46920 gatgaaggga tcgttaatga acaaatcctt ggcctttgat tcggctgatc tattatctcc 46980 gttatagacg ttacgttgac tagtccaaag acttacagga atagatgtat cgatgatgtt 47040 gatactatgt gatatgtgag caaagattgt tctcttagtg gcatcactat atgttccagt 47100 aatggcggaa aactttttag aaatgttata tataaaagaa ttttttcgtg ttccaaacat 47160 tagcagatta gtatgaagat aaacactcat attatcagga acattatcaa tttttacata 47220 cacatcagca tcttgaatag aaacgatacc atcttctgga acctcaacaa tctcggcaga 47280 ctccggataa ccagtcggtg ggccatcact aacaataact agatcatcca acaatctact 47340 cacatatgca tctatataat ctttttcatc ttgtgagtac cctggatacg aaataaattt 47400 attatccgta tttccataat aaggtttagt ataaacagag agcgatgttg ccgcatgaac 47460 ttcagtta ca gtcgccgttg gttggtttat ttgacctatt actctcctag gtttctctat 47520 aaacgatggt ttaatttgta cattcttaac catatatcca ataaagctca attcaggaac 47580 ataaacaaat tctttgttga acgtttcaaa gtcgaacgaa gagtcacgaa taacgatatc 47640 ggatactgga ttgaaggtta ccgttacggt aatttttgaa tcggatagtt taagactgct 47700 gaatgtatct tccacatcaa acggagtttt aatataaacg tatactgtag atggttcttt 47760 aatagtgtca ttaggagtta ggccaataga aatatcatta agttcactag aatatccaga 47820 gtgtttcaaa gcaattgtat tattgataca attattatat aattcttcgc cctcaatttc 47880 ccaaataaca ccgttacacg aagagataga tacgtgatta atacatttat atccaacata 47940 tggtacgtaa ccgaatcttc ccataccttt aacttctgga agttccaaac tcagaaccaa 48000 atgattaagc gcagtaatat actgatccct aatttcgaag ctagcgatag cctgattgtc 48060 tggaccatcg tttgtcataa ctccggatag agaaatatat tgcggcatat acaaagttgg 48120 aatttgacta tcgactgcga agacattaga ccgtttaata gagtcatccc caccgatcaa 48180 agaattaatg atagtattat tcattttcta tttaaaatgg aaaaagctta caataaactc 48240 cgtagagaaa tatctataat ttgtgagttt tccttaaagt aacagcttcc gtaaacgccg 48300 tctttatctc ttagtaggtt tattgtattt atgacctttt ccttatcttc atagaatact 48360 aaaggcaaca aagaaatttt tggttcttct ctaagagcta cgtgagactt aaccatagaa 48420 gccaacgaat ccctacatat tttagaacag aaatacccaa cttcaccacc cttgaatgtc 48480 tcaatactaa taggtctaaa aaccaaatct tgattacaaa accaacactt atcaattaca 48540 ctatttgtct taatagacac atctgccata gatttataat actttggtag tatacaagcg 48600 agtgcttctt ctttagcggg cttaaagact gctttaggtg ctgaaataac cacatctgga 48660 aggcttactc gcttagccat ttaattacgg aactattttt ttatacttct aatgagcaag 48720 tagaaaacct ctcatctaca aaaacatact cgtgtccata atcctctacc atagttacac 48780 gttttttaga tctcatatgt gctaaaaagt tttcccatac taattggtta ctattatttt 48840 tcgtataatt tttaacagtt tgaggtttta gatttttagt tacagaagtg atatcgaata 48900 ttttatccaa aaagaatgaa taattaattg tcttagaagg agtgttttct tggcaaaaga 48960 ataccaagtg cttaaatatt tctactactt cattaatctt ttctgtactc agattcagtt 49020 tctcatcttt tacttgattg attatttcaa agactaactt ataatccttt ttatttattc 49080 tctcgttagc cttaagaaaa ctagatacaa aatttgcatc tacatcatcc gtggatatt t 49140 gatttttttc catgatatcc aagagttccg agataatttc tccagaacat tgatgagaca 49200 ataatctccg caatacattt ctcaaatgaa taagtttatt agacacatgg aagtttgact 49260 ttttttgtac ctttgtacat ttttgaaata cagactcgca aaaaatacaa tattcatatc 49320 cttgttcaga tactataccg ttgtgtctac aaccgctaca taatcgtaga ttcatgttaa 49380 cactctacgt atctcgtcgt ccaatatttt atataaaaac attttatttc tagacgttgc 49440 cagaaaatcc tgtaatattt ttagtttttt gggctgtgaa taaagtatcg ccctaatatg 49500 gttaccgtcc tccgccaata tagtagttaa attatccgca catgcagaag aacaccgctt 49560 aggcggattc agtacaatgt tatatttttc gtaccaactc atttaaatat cataatctaa 49620 aatagttctg taatatgtct agcgctaata tattgatcat aatcctgtgc ataaattaag 49680 atacaacaat gtctcgaaat catcgacatg gcttcttcca tagttagaag atcgtcgtca 49740 aagttagcaa cgtgattcat caacatttgc tgttttgagg cagcaaatac tgaaccgtcg 49800 ccattcaacc attcataaaa accatcgtct gaatccattg ataatttctt gtactggttt 49860 ttgagagctc gcatcaatct agcatttcta gctcccggat tgaaaacaga aagaggatcg 49920 tacatccagg gtccattttc tgtaaataga atcgtataat gtcccttcaa g aagatatca 49980 gacgatccac aatcaaagaa ttggtctccg agtttgtaac aaactgcgga ctttaaccta 50040 tacatgatac cgtttagcat gatttctggt gatacgtcaa tcggagtatc atctattaga 50100 gatctaaagc cggtgtaaca ttctccacca aacatattct tattctgacg tcgttctaca 50160 taaaacatca ttgctccatt aacgataaca ggggaatgaa cagcactacc catcacatta 50220 gttcccaatg gatcaatgtg tgtaactcca gaacatcttc catatcctat gttaggagga 50280 gcgaacacca ctcttccact attgccatcg aatgccatag aataaatatc cttggaattg 50340 atagaaatcg gactgtcgga tgttgtgatc atcttcatag gattaacaac tatgtatggt 50400 gccgcctgaa gtttcatatc gtaactgatg ccgtttatag gtctagccac agaaaccaac 50460 gtaggtctaa atccaactat agacaaaata gaagccaata tctgttcttc atctgtcata 50520 acttgagagc atccagtatg aataatcttc attagatggg gatctaccgc atcatcatcg 50580 ttacaataaa aaattcccat tctaatgttc ataattgctt ttctaatcat ggtatgcatg 50640 tttgctctct gaatctctgt ggaaattaga tctgatacac ctgtaatcac tatcggatta 50700 tcctccgtaa gacgattaac caacaacata taattataag actttacttt tctaaattca 50760 taaagttgct ggattaggct ataggtgtct ccatgtacat acgc gttctc gagcgcagga 50820 agtttaatac cgaatagtgc catcagaata ggatgaatat agtaattagt ttctggtttt 50880 ctataaataa aagacaaatc ttgtgaacta gacatatcgg taaaatgcat ggattggaat 50940 cgtgtagtcg acagaagaat atgatgatta gatggagagt atattttatc taactctttg 51000 agttggtcac cgattctagg actagctcga gaatgaataa gtactaaagg atgagtacat 51060 ttcacagaaa cactagcatt gttcaatgtg ctctttacat gggtaaggag ttgaaatagc 51120 tcgtttctat ttgttctgac aatatttagt ttattcataa tgttaagcat atcctgaata 51180 gtaaagttag atgtgtcata cttgttagta gttagatatt tagcaattgc attcccatca 51240 tttctcaatc tcgtactcca atcatgcgtg gatgctactt cgtcgatgga aaccatacaa 51300 tcctttttga taggctgttg agattgatta tttcctgcac gtttaggttt ggtacgttga 51360 tttctagccc ctgcggatat aaagtcatcg tctacaattt tggataatga attgcataca 51420 ctacaagaca aagatttatc agaagtgtga atatgatctt catctaccaa agaaagagtt 51480 tgattagtat aactagattt tagtcctgcg ttagatgtta aaaaaacatc gctattgacc 51540 acggcttcca ttatttatat tcgtagtttt tactcgaaag cgtgatttta atattcaatc 51600 ttattacttt tggaatcgtt caaaaccttt gactaat tgt agaatttgat ctattgccct 51660 acgcgtatac tcccttgcat catatacgtt cgtcaccaga tcgtttgttt cggcctgaag 51720 ttggtgcata tctctttcaa cattcgacat gagatcctta agggccatat cgtctagatt 51780 ttgttgagat gctgctcctg gatttggatt ttgttgtgct gttgtacata ctgtaccacc 51840 agtaggtgta ggagtacata cagtggccac aataggaggt tgaggaggtg taaccgttgg 51900 agtagtacaa gaaatacttc catccgattg ttgtgtacat gtagttgttg gtaacgtctg 51960 agaaggttgg gtagatggcg gcgtcgtcgt cttttgatct ttattaaatt tagagataat 52020 atcctgaaca gcattgctcg gcgtcaacgc tggaaggagt gaactcgccg gcgcatcagt 52080 atctgcagac agccaatcaa aaagattaga catatcagat gatgtattag tttgttgtcg 52140 tggttttggt gtaggagccg gtgtagctgt tggaaccggc tgtggagtta tatgaatagt 52200 tggttgtagc ggttggatag gctgtctgct ggcggccatc atattatctc tagctagttg 52260 ttctcgcaac tgtctttgat aatacgactc ttgagacttt agtcctattt caatcgcttc 52320 atcctttttc gtatccggat ccttttcttc agaataatag attgacgact ttggtgtaga 52380 ggattctgcc agcccctgtg agaacttgtt aaagaagtcc atttaaggct ttaaaattga 52440 attgcgatta taagattaaa tggcagacac agacgatatt atcgactatg aatccgatga 52500 tctcaccgaa tacgaggatg atgaagaaga ggaagaagat ggagagtcac tagaaactag 52560 tgatatagat cccaaatctt cttataagat tgtagaatca gcatccactc atatagaaga 52620 tgcgcattcc aatcttaaac atatagggaa tcatatatct gctcttaaac gacgctatac 52680 tagacgtata agtctatttg aaatagcggg tataatagca gaaagctata acttgcttca 52740 acgaggaaga ttacctctag tttcagaatt ttctgacgaa acgatgaagc aaaatatgct 52800 acatgtaatt atacaagaga tagaggaggg ttcttgtcct atagtcatcg aaaagaacgg 52860 agaattgttg tcggtaaacg attttgacaa agatggtcta aaattccatc tagactatat 52920 tatcaaaatt tggaaacttc aaaaacgata ttagaattta tacgaatatc gttctctaaa 52980 tgtcacaatc aagtctcgca tgttcagcaa tttattgtcg tactttatat cgtgttcatt 53040 aacgatatct tgcaaaatag taatgattct atcttccttc gatagatatt cttcagagat 53100 tattgtctta tattctttct tgttatcaga tatgaatttg ataagacttt gaacattatt 53160 gatacccgtc tgtttaattt tttctacaga tattttagtt ttggcagatt ctatcgtatc 53220 tgtcaataga catccaacat cgacattcga cgtcaattgt ctataaatca acgtataaat 53280 tttagaaata acattagcga at tgttgtgc attgatgtcg ttattctgaa acagtatgat 53340 tttaggtagc attttcttaa caaagagaac gtatttattg ttactcagtt gaacagatga 53400 tatatccaga ttactaacgc atctgattcc atataccaaa ctttcagaag aaatggtgta 53460 caattgtttg tattcattca atgtctcttt ttcagaaatt agtttagagt cgaatactgc 53520 aataattttc aagagatagt tttcatcaga taagatttta tttagtgtag atatgataaa 53580 actattgttt tgttggagaa cttgatacgc cgcgttctct gtagtcgacg ctctcaaatg 53640 ggaaacaatc tccattattt ttttggaatc ggatacaata tcttcggtat cttgacgcaa 53700 tctagtatac atagagttaa gagaaattag agtttgtaca ttaagcaaca tgtctctaaa 53760 tgtggctgca aacttttcct tttccacatc atctagttta ttatataccg atttcacaac 53820 ggcaccagat ttaaggaacc agaatgaaaa actctgataa ctacaatatt tcatcatagt 53880 tacgatttta tcatcttcta tagttggtgt aatagcgcat acctttttct ccaagactgg 53940 aaccaacgtc ataaaaatgt ttaaatcaaa atccatatca acatctgatg cgctaagacc 54000 agtctcgcgt tcaagattat ctttactaat ggtgacgaac tcatcgtata gaactctaag 54060 tttgtccatt atttatttac agatttagtt gtttaattta tttgtgctct tccagagttg 54120 ggatagtatt tttct aacgt cggtattata ttattaggat ctacgttcat atgtatcata 54180 atattaatca tccacgtttt gataaatcta tctttagctt ctgaaataac gtatttaaac 54240 aaaggagaaa aatatttagc tacggcatca gacgcaataa tatttagtt gttaacta 54180 tatttagtt gttacta 360 tatttagtat gttacta aacaccattc ccgcgtcaga ttgaatagga gtttgaatag tttgttttgg aaatagatcc 54420 ttcaataact tatagttggg tgggaaaaaa tcgattttat cactagactc tttctttttt 54480 actatcatta cctcatgaac tatttcttga atgagtatat gtattttctt tcctatatcg 54540 gacgcgttca ttggaaaata taccatgtcg ttaactataa gaatattttt atcctcgttt 54600 acaaactgaa taatatcaga tgtagttcgt aaacgaacta tatcatcacc agcacaacat 54660 ctaactatat gatatccact agtttccttt agtcgtttat tatcttgttc catattagca 54720 gtcattccat catttaagaa ggcgtcaaag ataataggga gaaatgacat tttggattct 54780 gttacaactt taccaaaatt aaggatatac ggacttacta tctttttctc aacgtcgatt 54840 tgatgaacac acgatgaaaa tgtacttcga tgagattgat catgtagaaa acaacaaggg 54900 atacaatatt tccacatatc atgaaatata ttaagaaatc ccaccttatt atatttcccc 54960 aaaggatcca tgcatgtaaa cattatgccg ttatcattaa taaagacttc tttctcatcg 55020 gatctgtaaa agttgttact gatttttttc attccaggat ctagataatt aataatgatg 55080 ggttttctat tcttattctt tgtattttgg catatcctag accagtaaac agtttccact 55140 ttggtaaaat cagcagactt ttgaacgcta ttaaacatgg cattaatggc aataactaa a 55200 aatgtaaaat atttttctat gttaggaata tggtttttca ctttaataga tatatggttt 55260 ttggccaaaa tgatagatat ttttttatcc gaggatagta aaatattatt agtcgccgtc 55320 tctataaaaa tgaagctagt ctcgatatcc aattttattc tagaattgat aggagtcgcc 55380 aaatgtacct tatacgttat atctcccttg atgcgttcca tttgtgtatc tatatcggac 55440 acaagatctg taaatagttt tacgttatta atcatcacgg tatcgccgtc gctagataac 55500 gctaatgtac catccaagtc ccaaatggag agatttaact gttcatcgtt tagaataaaa 55560 tgattaccgg tcatattaat aaagtgttca tcgtatctag ataacaacga cttataatta 55620 atgtccaagt cttgaactcg ctgaatgatc ttttttaacc cagttagttt tagattggta 55680 cgaaatatat tgttaaactt tgattctaca gtaatgtcca aatctagttg tggaaatact 55740 tccatcaaca ttgtttcaaa cttgataata ttattatcta catcttcata cgatccaaat 55800 tccggaatag atgtatcgca cgctctggcc acccagataa ccaaaaagtc acacgctcca 55860 ggatatacat tgtataaaaa gctatcgttt tttagtagtg tttttttctg agtatatacg 55920 aagggattaa aaatagtatt atcaacgtaa ctatattcca aattattctt atgagaatag 55980 ataataatat cgtccttaat atctaacaaa tttcctaaat atccctttaa t tgagtcatt 56040 cgaagcgtca atagaatatg tctcttaact atttccggct gttgtatatt taaatgactt 56100 cgtaaaaaat aatatatggg cgacttctca tctatgtaat catatggagt gagatatagg 56160 gctcgttcta cctcctgccc cttacccacc tgtaatacca attgcggact tactatatat 56220 cgcatattta tatcgtgggg taaagtgaaa atctactacc gatgatgtaa gtcttacaat 56280 gttcgaacca gtaccagatc ttaatttgga ggcctccgta gaactagggg aggtaaatat 56340 agatcaaaca acacctatga taaaggaaaa tagcggtttt atatcccgta gtagacgtct 56400 attcgcccat agatctaagg atgatgagag aaaactagca ctacgattct ttttacaaag 56460 actttatttt ttagatcata gagagattca ttatttgttc agatgcgttg acgctgtaaa 56520 agacgtcact attaccaaaa aaaataacat tatcgtggcg ccttatatag cacttttaac 56580 tatcgcatca aaaggatgca aacttacaga aacaatgatt gaagcattct ttccagaact 56640 atataatgaa catagtaaga aatttaaatt caactctcaa gtatccatca tccaagaaaa 56700 actcggatac cagtttggaa actatcacgt ttatgatttt gaaccgtatt actctacagt 56760 agctctggct attcgagatg aacattcatc tggcattttt aatatccgtc aagagagtta 56820 tctggtaagt tcattatctg aaataacata tagattttat ctaa ttaatc taaaatctga 56880 tcttgttcaa tggagtgcta gtacgggcgc tgtaattaat caaatggtaa atactgtatt 56940 gattacagtg tatgaaaagt tacaactggt catagaaaat gattcacaat ttacatgttc 57000 attggctgtg gaatcaaaac ttccaataaa attacttaaa gatagaaatg aattatttac 57060 aaaattcatc aacgagttaa aaaagaccag ttcattcaag ataagcaaac gcgataagga 57120 tacgctacta aaatatttta cttaggactg gagttagaat ttatagacga ctcatttcgt 57180 ttatcattat tagtattctt cttgttatct tgttcagaaa tatacagcaa tgctatgcct 57240 aatactaaat acattatcat gcttgcaatg gctctaacaa cgacgaacca aaatgaattt 57300 ggtcgtagct tttgttcaca aaaatacata aagaaatgtc tacataaatc tatggcgcca 57360 ttggctactt gaaatagcgc cagtcctcct acagatttta atatagctgt ataacatgac 57420 atttattcat catcaaaaga gacagagtca ccatctgtca tatttagatt ttttttcatg 57480 tgttcaaagt atcctctact catttcatta taatagttta tcatacttag aattttagga 57540 cggatcaatg agtaagactt gactagatcg tcagtagtaa tttgtgcatc gtctattctg 57600 catccgcttc gtcgaataat gtatagcatc gctttgagat tctccatagc tatcaagtct 57660 ttatacaatg acatggaaat atctgtgaat actttat act tctccaacat cgatgcctta 57720 acatcatcgc ctactttagc attgaaaata cgttctattg tgtagatgga tgtagcaaga 57780 tttttaaaca acaatgccat tttacacgat gattgcctca agtctccaat cgtttgttta 57840 gaacgattag ctacagagtc caatgcttgg ctgactagca tattattatc tttagaaatt 57900 gtattcttca atgaggcgtt tatcatatct gtgatttcgt tagtcatatt acagtctgac 57960 tgggttgtaa tgttatccaa catatcacct atggatacgg tacacgtacc agcatttgta 58020 ataatcctat ctaagatgtt gtatggcatt gcgcagaaaa tatcttctcc tgtaatattt 58080 ccactctcga taaatctact cagattattc ttaaatgcct tattctctgg agaaaagata 58140 tcagtgtcca tcatttcatt aatagtatac gcagaaaaga taccacgagt atcaattcta 58200 tccaagatac ttatcggttc cgagtcacag ataatggttt cctctccttc gggagatcct 58260 gcatagaaat atctaggaca atagtttcta tactgtctgt aactctgata atctctaaag 58320 tcactaactg ataccatgaa attgagaaga tcaaacgctg aagtaattaa tttttctgcc 58380 tcgtttttac tacaactagt tttcatcaat gtagtgacga tgtattgttt agttactctt 58440 ggtctaatac tgatgataga gatattatta cttcccataa tggatcttct agtagtcacc 58500 ttaaagccca ttgatgcaaa tagcagatag ataaagtctt ggtatgactc ctttctaata 58560 tagtacggac tacctttgtc acccaacttt atacccacat aagccataac aacctcttta 58620 atagccgttt catgaggttt atcagccatg agcctgagta gttggaagaa tctcatgaat 58680 cctgtctcag aaagtcctat atgcatgata gatttatctt tcctgggaaa ctctcgtata 58740 gtcatagatg aaatactctt caaagtttct gaaataagat tagtaacagt cttacctccg 58800 actactctag gtaacaaaca aactctaata ggtgttttct ctgcggagat aatatcagaa 58860 aggatagagc aataagtagt attattgtga ttataaagac cgaatacata acaggtagaa 58920 tttataaaca tcatgtcctg aaggttttta gacttgtatt cctcgtaatc cataccgtcc 58980 caaaacatgg atttggtaac tttgatagcc gtagatcttt gttccttcgc caacaggtta 59040 aagaaattaa taaagaattt gtggtttcta cctatgtcta caaattgcac gtttggaagc 59100 gccacggtta cattcactgc agcattttga ggatcgcgag tatgaagtac gatgttattg 59160 tttactggta tatctggaaa gaattctacc agtctaggaa taagagattg atatcgcata 59220 gaaatacaaa agttcataat ctcatcatct aagagcattt tgttaccatt gtaataaata 59280 tccactctgt catatgtata aatgaagtac tgttcaaaca tgatgagatg tttatatgtt 59340 ggcatagtag tgagatctac gt ttggtaat ggcaatgtat taagattaac tccataatgt 59400 ctagcagcat ctgcgatgtt ataagcgttg tcaaagcggg gtcgatcttg tgctgttata 59460 tattgtctaa cacctataag attatcaaaa tcttgtctgc ttaatacacc gttaacaatt 59520 tttgccttga attcttttat tggtgcatta ataacatcct tatagaggat gttaaacaaa 59580 taagtgttat caaagttaag atctggatat ttcttttctg ctagaacatc cattgagtcg 59640 gagccatctg gtttaatata accaccgata aatctagctc tgtattctgt atccgtcaat 59700 ctaatattaa gaaggtgttg agtgaaaggt ggaagatcgt aaaagctgtg agtattaatg 59760 ataggattag tttccgaact aatgttaatt ggggtattaa taatatctat atttccagcg 59820 ttaagtgtaa cattaaacag ttttaattca cgtgacgtgg tatcaattaa ataattaatg 59880 cccaatttgg atatagcagc ctgaagctca tcttgtttag ttacggatcc taatgagtta 59940 ttaagcaata tatcgaacgg atgaacgaag gttgttttaa gttggtcaca tactttgtaa 60000 tctagacata gatgcggaag aacggtagaa actatacgaa ataaatattc agagtcctct 60060 aattgatcaa gagtaactat tgacttaata ggcatcattt atttagtatt aaatgacgac 60120 cgtaccagtg acggatatac aaaacgattt aattacagag ttttcagaag ataattatcc 60180 atctaacaaa aatta tgaaa taactcttcg tcaaatgtct attctaactc acgttaacaa 60240 cgtggtagat agagaacata atgccgccgt agtgtcatct ccagaggaaa tatcctcaca 60300 acttaatgaa gatctatttc cagatgatga ttctccggcc actattatcg aacgagtaca 60360 acctcatact actattattg acgatactcc acctcctacg tttcgtagag agttattgat 60420 atcggaacaa cgtcaacaac gagaaaaaag atttaatatt acagtatcga aaaatgctga 60480 agcaataatg gaatctagat ctatgatatc ttctatgcca acacaaacac catccttggg 60540 agtagtttat gataaagata aaagaattca gatgttggag gatgaagtgg ttaatcttag 60600 aaatcaacga tctaatacaa aatcatctga taatttagat aattttacca gaatactatt 60660 tggtaagact ccgtataaat caacagaagt taataagcgt atagccatcg ttaattatgc 60720 aaatttgaac gggtctccct tatcagtcga ggacttggat gtttgttcag aggatgaaat 60780 agatagaatc tataaaacga ttaaacaata tcacgaaagt agaaaacgaa aaattatcgt 60840 cactaacgtg attattattg tcataaatat tatcgagcaa gcattgctaa aactcggatt 60900 tgaagaaatc aaaggactga gtaccgatat cacttcagaa attatcgatg tggagatcgg 60960 agatgactgc gatgctgtag catcaaaact aggaatcggt aacagtccgg ttcttaatat 61020 tgtattgt tt atactcaaga tattcgttaa acgaattaaa attatttaat ttaatacatt 61080 cccatatcca gacaacaatc gtctggatta atctgttcct gtcgtctcat accggacgac 61140 atattaatct ttttattagt aggcatcttt ttagatggtt tctttttccc agcattaact 61200 gagtcgatac ctagaagatc gtgattgatc tctccgacca ttccacgaac ttctaattgg 61260 ccgtctctga cggtaccata aactatttta ccagcattag taacagcttg gacaatctga 61320 ccatccatcg cattgtacga tgtagtagta actgttgttc tacgtctagg agcaccagaa 61380 gtatttttgg agcccttgga tgttgatgta gaagaagacg aggattttga ttttggttta 61440 catgtaatac attttgtatc acatgcgccg gcagtcacat ctgtttgaga attaagatta 61500 ttgttgcctc ctttgacggc tgcatctcca ccgatttgcg ctagtagatt tttaagctgt 61560 ggtgtaatct tattaactgt ttcgatataa tcatcgtaac tgcttctaac ggctaaattt 61620 tttttatccg ccatttagaa gctaaaaata tttttattta tgcagaagat ttaactagat 61680 tatacaatga actaatatga tccttttcca gattatttac aaacttggta ttttttggtt 61740 ctggaggagg cgaatttaaa ttcggacttg gatttggatt ttgtgggttc ttgatcttat 61800 tatacagcgc atataggatg gcgacggtaa ctgctacgca aataccgatc aacaaaagaa 61860 taccaatcat ttattgacaa taacttcact attgatcaag tatgcaatat atcatctttt 61920 cactaaataa gtagtaataa tgattcaaca atgtcgagat atatggacga taataattta 61980 gttcatggaa atatcgctat gattggtatg aatgactccg ctaactctgt ggggcgcgca 62040 gtgctttccc cacatagaat aaattagcat tccgactgtg ataataatac caagtataaa 62100 cgccataata ctcaatactt tccatgtacg agtgggactg gtagacttac taaagtcaat 62160 aaaggcgaag atacacgaaa gaatcaaaag aatgattcca gcgattagca cgccggaaaa 62220 ataatttcca atcataagca tcatatccat ttaactaata aaaattttaa atcgccgaat 62280 gaacaaagtg gaatataaac catataaaaa caatagtttg tactgcaaaa ataatatcta 62340 tttttgtttt cgaagatatg gtaaaattaa atagtagtac acagcatgtt ataactaaca 62400 gcagcaacgg ctcgtaatta cttatcattt actagacgaa aaggtggtgg gatattttct 62460 tgctcaaata atacgaatat atcacccatc cattttatgc gatgtttata tactctaatc 62520 tttaatagat ctatagacga cgggtttacc aacaatatag attttatcga ttcatctaat 62580 ttaaaccctt ccttaaacgt gaatgatcta ttatctggca taacgatgac tctacccgat 62640 gaatcggaca atgtactggg ccatgtagaa taaattatca acgaattatc gtctacgaa c 62700 atttatatca tttgttttaa ttttagtacg cgaataaata gatataaaat agaaaataac 62760 agatattaca accaatgtta tggccgcgcc cggccggccg cggccgcttt ttttctagac 62820 actaaataaa tagtaagatt aaattaatta taaaattatg tatataatat taattataaa 62880 attatgtata tgatttacta actttagtta gataaattaa taatacataa attttagtat 62940 attaatatta taaattaata atacataaat tttagtatat taatattata ttttaaatat 63000ttatttagtg tctagaaaaa aaggcctagc aggcc 63035 <210> 14
<211> 62068
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA fragment 3
<400> 14 ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60 attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120 aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180 gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccgggt 240 attaataata tctatatttc cagcgttaag tgtaacatta aacagtttta attcacgtga 300 cgtggtatca attaaataat taatgcccaa tttggatata gcagcctgaa gctcatcttg 360 tttagttacg gatcctaatg agttattaag caatatatcg aacggatgaa cgaaggttgt 420 tttaagttgg tcacatactt tgtaatctag acatagatgc ggaagaacgg tagaaactat 480 acgaaataaa tattcagagt cctctaattg atcaagagta actattgact taataggcat 540 catttattta gtattaaatg acgaccgtac cagtgacgga tatacaaaac gatttaatta 600 cagagttttc agaagataat tatccatcta acaaaaatta tgaaataact cttcgtcaaa 660 tgtctattct aactcacgtt aacaacgtgg tagatagaga acataatgcc gccgtagtgt 720 catctccaga ggaaatatcc tcacaactta atgaagatct atttccagat gatgattctc 780 cggccactat tatcgaacga gtacaacctc atactactat tattgacgat actccacctc 840 ctacgtttcg t agagagtta ttgatatcgg aacaacgtca acaacgagaa aaaagattta 900 atattacagt atcgaaaaat gctgaagcaa taatggaatc tagatctatg atatcttcta 960 tgccaacaca aacaccatcc ttgggagtag tttatgataa agataaaaga attcagatgt 1020 tggaggatga agtggttaat cttagaaatc aacgatctaa tacaaaatca tctgataatt 1080 tagataattt taccagaata ctatttggta agactccgta taaatcaaca gaagttaata 1140 agcgtatagc catcgttaat tatgcaaatt tgaacgggtc tcccttatca gtcgaggact 1200 tggatgtttg ttcagaggat gaaatagata gaatctataa aacgattaaa caatatcacg 1260 aaagtagaaa acgaaaaatt atcgtcacta acgtgattat tattgtcata aatattatcg 1320 agcaagcatt gctaaaactc ggatttgaag aaatcaaagg actgagtacc gatatcactt 1380 cagaaattat cgatgtggag atcggagatg actgcgatgc tgtagcatca aaactaggaa 1440 tcggtaacag tccggttctt aatattgtat tgtttatact caagatattc gttaaacgaa 1500 ttaaaattat ttaatttaat acattcccat atccagacaa caatcgtctg gattaatctg 1560 ttcctgtcgt ctcataccgg acgacatatt aatcttttta ttagtaggca tctttttaga 1620 tggtttcttt ttcccagcat taactgagtc gatacctaga agatcgtgat tgatctctcc 1680 gaccattcca cgaacttct a attggccgtc tctgacggta ccataaacta ttttaccagc 1740 attagtaaca gcttggacaa tctgaccatc catcgcattg tacgatgtag tagtaactgt 1800 tgttctacgt ctaggagcac cagaagtatt tttggagccc ttggatgttg atgtagaaga 1860 agacgaggat tttgattttg gtttacatgt aatacatttt gtatcacatg cgccggcagt 1920 cacatctgtt tgagaattaa gattattgtt gcctcctttg acggctgcat ctccaccgat 1980 ttgcgctagt agatttttaa gctgtggtgt aatcttatta actgtttcga tataatcatc 2040 gtaactgctt ctaacggcta aatttttttt atccgccatt tagaagctaa aaatattttt 2100 atttatgcag aagatttaac tagattatac aatgaactaa tatgatcctt ttccagatta 2160 tttacaaact tggtattttt tggttctgga ggaggcgaat ttaaattcgg acttggattt 2220 ggattttgtg ggttcttgat cttattatac agcgcatata ggatggcgac ggtaactgct 2280 acgcaaatac cgatcaacaa aagaatacca atcatttatt gacaataact tcactattga 2340 tcaagtatgc aatatatcat cttttcacta aataagtagt aataatgatt caacaatgtc 2400 gagatatatg gacgataata atttagttca tggaaatatc gctatgattg gtatgaatga 2460 ctccgctaac tctgtggggc gcgcagtgct ttccccacat agaataaatt agcattccga 2520 ctgtgataat aataccaagt ataa acgcca taatactcaa tactttccat gtacgagtgg 2580 gactggtaga cttactaaag tcaataaagg cgaagataca cgaaagaatc aaaagaatga 2640 ttccagcgat tagcacgccg gaaaaataat ttccaatcat aagcatcata tccatttaac 2700 taataaaaat tttaaatcgc cgaatgaaca aagtggaata taaaccatat aaaaacaata 2760 gtttgtactg caaaaataat atctattttt gttttcgaag atatggtaaa attaaatagt 2820 agtacacagc atgttataac taacagcagc aacggctcgt aattacttat catttactag 2880 acgaaaaggt ggtgggatat tttcttgctc aaataatacg aatatatcac ccatccattt 2940 tatgcgatgt ttatatactc taatctttaa tagatctata gacgacgggt ttaccaacaa 3000 tatagatttt atcgattcat ctaatttaaa cccttcctta aacgtgaatg atctattatc 3060 tggcataacg atgactctac ccgatgaatc ggacaatgta ctgggccatg tagaataaat 3120 tatcaacgaa ttatcgtcta cgaacattta tatcatttgt tttaatttta gtacgcgaat 3180 aaatagatat aaaatagaaa ataacagata ttacaaccaa tgttatggcc gcgcccaacc 3240 aggtaggcag ttttatttta tcttttacta caggttctcc tggatgtacg tcaccaacgg 3300 cggacgtagt tctagtacaa ttagacgtaa gttccgcttg ggaatttttt aacgctaaag 3360 agttaacgtt aatcgtgcac ccaacgtatt tacatctagt tctttgaaca tcttgattat 3420 aatataacca ttttctatct ctagattcgt cggtgcactc atgtaaccaa cataccctag 3480 gtcctaaata tttatctccg gaattagatt ttggataatt cgcgcaccaa caatttctat 3540 ttcctttatg atcgttacaa aagacgtata atgccgtatc cccaaaagta aaataatcag 3600 gacgaataat tctaataaac tcagaacaat atctcgcatc catatgtttg gagcaaatat 3660 cggaataagt agacatagcc ggtttccgtt ttgcacgtaa ccattctaaa caattggggt 3720 ttccaggatc gtttctacaa aatccagtca tgaaatcatc acaatgttct gtcttgtaat 3780 tattattaaa tatttttgga cagtgtttgg tatttgtctt agaacaacat tttgccacgc 3840 tatcactatc gcccaggaga taatcctttt ttataaaatg acatcgttgc ccggatgcta 3900 tataatcagt agcgtgtttt aaatccttaa tatattcagg agttacctcg ttctgataat 3960 agattaatga tccaggacga aatttgaaag aactacatgg ttctccatga attaatacat 4020 attgtttagc aaattcagga actataaaac tactacaatg atctatcgac ataccatcta 4080 tcaaacaaaa cttgggttta atttctcccg gagatgtttc ataatagtac gtataacttt 4140 cttctgcaaa cttaacagct ctattatatt caggataatt aaaacctaat tccatatatt 4200 tgtctcgtat atctgctatt cctggtgcta ttttg attct attaagagta acggctgccc 4260 ccatttttaa taatcgtcag tatttaaact gttaaatgtt ggtatatcaa catttacctt 4320 atttcccgca gtataaggtt tgttgcaggt atactgttca ggaatggtta catttatact 4380 ttttctatag tcctgtcttt cgatgttcat cacatatgca aagaacagaa taaacaaaat 4440 aatgtaagaa ataatattaa atatctgtga attcgtaaat acattgattg ccataataat 4500 tacagcagct acaatacata caatagacat tcccacagtg ttgccattac ctccacgata 4560 catttgagtt actaagcaat aggtaataac taagctagta agaggcaata gaaaagatga 4620 gataaatatc atcaatatag agattagagg agggctatat agagccaaga cgaacaaaat 4680 caaaccgagt aacgttctaa catcattatt tttgaagatt cccaaataat cattcattcc 4740 tccataatcg ttttgcatca tacctccatc tttaggcata aacgattgct gctgttcctc 4800 tgtaaataaa tctttatcaa gcactccagc acccgcagag aagtcgtcaa gcatattgta 4860 atatcttaaa taactcattt atatattaaa aaatgtcact attaaagatg gagtataatc 4920 tttatgccga actaaaaaaa atgacttgtg gtcaacccct aagtcttttt aacgaagacg 4980 gggatttcgt agaagttgaa ccgggatcat cctttaagtt tctgatacct aagggatttt 5040 acgcctctcc ttccgtaaag acgagtctag tatttgaaac attaacaacg accgataata 5100 aaattactag tatcaatcca acaaatgcgc caaagttata tcctcttcaa cgcaaagtcg 5160 tatctgaagt agtttctaat atgaggaaaa tgatcgaatc aaaacgtcct ctatacatca 5220 ctcttcactt ggcgtgtgga tttggtaaga ctattaccac gtgttatctt atggctacac 5280 acggtagaaa aaccgtcatt tgcgtaccca ataaaatgtt aatacatcaa tggaagacac 5340 aggtagaggc agtcggattg gaacataaga tatccataga tggagtaagt agtctattaa 5400 aggaactaaa gactcaaagt ccggatgtat taatagtagt cagtagacat ctgacaaacg 5460 atgccttttg taaatatatc aataagcatt atgatttgtt catcttggat gaatcacata 5520 cgtataatct gatgaacaat acagcagtta caagattttt agcgtattat cctccgatga 5580 tgtgttattt tttaactgct acacctagac catctaacag aatttattgt aacagtatta 5640 ttaatattgc caagttatcc gatctaaaaa aaactatcta tgcagtagat agtttttttg 5700 agccatattc cacagataat attagacata tgataaaacg attagatgga ccatctaata 5760 aatatcatat atataccgag aagttattat ctgtagacga gcctagaaat caacttattc 5820 ttaataccct ggtagaagaa ttcaagtcag gaactattaa tcgcatttta gttattacta 5880 aactacgtga acatatggta ttcttctaca aacgattatt agattt tttc ggatcagagg 5940 ttgtatttat aggagacgcc caaaatagac gtactccaga tatggtcaaa tcaatcaagg 6000 aactaaatag atttatattc gtatccacct tattttattc cggtactggt ttagatattc 6060 ctagtttgga ttctttgttc atttgctcgg cagtaatcaa caatatgcaa atagagcaat 6120 tactagggag ggtatgtcga gaaacagaac tattagatag gacggtatat gtatttccta 6180 gcacatccat caaagaaata aagtacatga taggaaattt cgttcaacga attattagtc 6240 tgtctgtaga taaactagga tttaaacaaa aaagttatcg gaaacatcaa gaatccgatc 6300 ccacttctgt atgtacaaca tcctccagag aagaacgtgt attaaataga atatttaact 6360 cgcaaaatcg ttaagaagtt taagcgacga tccgcatgct gcgcaggcca gtgtattacc 6420 cctcatagta ttaatataat ccaatgatac ttttgtgatg tcggaaatct taaccaattt 6480 agactgacag gcagaacacg tcatgcaatc atcatcgtca tcgataactg tagtcttggg 6540 cttctttttg cggctcttca ttccggaacg cacattggtg ctatccattt aggtagtaaa 6600 aaataagtca gaatatgccc tatagcacga tcgtgcaaaa cctggtatat cgtctctatc 6660 tttatcacaa tatagtgtat cgacatcttt attattattg acctcgttta tcttggaaca 6720 tggaatggga acatttttgt tatcaacggc cacctttgcc ttaattccag a tgttgtaaa 6780 attataacta aacagtctat catcgacaca aatgaaattc ttgtttagac gtttgtagtt 6840 tacgtatgcg gctcgttcgc gtctcatttt ttcagatatt gcaggtacta taatattaaa 6900 aataagaatg aaataacata ggattaaaaa taaagttatc atgacttcta gcgctgattt 6960 aactaactta aaagaattac ttagtctgta caaaagtttg aaattttcag attctgcggc 7020 tatagaaaag tataattctt tggtagaatg gggaacatct acttactgga aaataggcgt 7080 gcaaaaggta gctaatgtcg agacgtcaat atctgattat tatgatgagg taaaaaataa 7140 accgtttaat attgatccgg gctattacat tttcttaccg gtatattttg ggagcgtctt 7200 tatttattcg aagggtaaaa atatggtaga acttggatct ggaaactctt ttcaaatacc 7260 agatgatatg cgaagtgcgt gtaacaaagt attagacagc gataacggaa tagactttct 7320 gagatttgtt ttgttaaaca atagatggat aatggaagat gctatatcaa aatatcagtc 7380 tccagttaat atatttaaac tagctagtga gtacggatta aacataccca aatatttaga 7440 aattgaaata gaggaagaca cattatttga cgacgagtta tactctatta tagaacgctc 7500 tttcgatgat aaatttccaa aaatatccat atcgtatatt aagttgggag aacttaggcg 7560 gcaagttgta gactttttca aattctcatt catgtatatt gagtccatca aggtaga tcg 7620 tataggagat aatattttta ttcctagcgt tataacaaaa tcaggaaaaa agatattagt 7680 aaaagatgta gaccatttaa tacgatccaa ggttagagaa catacatttg taaaagtaaa 7740 aaagaaaaac acattttcca ttttatacga ctatgatgga aacggaacag aaactagagg 7800 agaagtaata aaacgaatta tagacactat aggacgagac tattatgtta acggaaagta 7860 tttctctaag gttggtagtg caggcttaaa gcaattgact aataaattag atattaatga 7920 gtgcgcaact gtcgatgagt tagttgatga gattaataaa tccggaactg taaaacgaaa 7980 aataaaaaac caatcagcat ttgatttaag cagagaatgt ttgggatatc cagaagcgga 8040 ttttataacg ttagttaata acatgcggtt caaaatagaa aattgtaagg ttgtaaattt 8100 caatattgaa aatactaatt gtttaaataa cccgagtatt gagactatat atggaaactt 8160 taaccagttc gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat tattcgagtg 8220 aaataatatg cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt ttagaagtca 8280 aggataactc cgttagggta ttggatatat caaaattaga ctggagttct gattgggaaa 8340 ggcacatagc taaagatttg tcacaatatg aatacactac agttcttcta gaacgtcagc 8400 ctagaaggtc gccgtacgtc aaatttatct attttattaa aggcttttta tatcatacat 84 60 cggctgccaa agttatttgc gtctcgcctg tcatgtctgg taattcatat agagatcgaa 8520 aaaagagatc ggtcgaagca tttcttgatt ggatggacac attcggattg cgagactccg 8580 ttccggatag acgcaaatta gacgatgtag cggatagttt caatttggct atgagatacg 8640 tattagataa atggaatact aattatacac cttataatag gtgtaaatct agaaattaca 8700 taaaaaaaat gtaataacgt tagtaacgcc attatggata atctatttac ctttctacat 8760 gaaatagaag atagatatgc cagaactatt tttaactttc atctaataag ttgcgatgaa 8820 ataggagata tatatggtct tatgaaagaa cgcatttcct cagaggatat gtttgataat 8880 atagtgtata ataaagatat acatcatgcc attaagaaac tagtgtattg cgacatccaa 8940 cttactaaac acattattaa tcagaatacg tatccggtat ttaacgattc ttcacaagtg 9000 aaatgttgtc attatttcga tataaactca gataatagca atattagctc tcgtacagta 9060 gagatatttg agagggaaaa gtcatctctt gtatcatata ttaaaactac caataagaag 9120 agaaaggtca attatgggga aataaagaaa actgtacatg gaggcactaa tgcaaattac 9180 ttttccggta aaaagtctga tgagtatctg agcactacag tcaggtccaa cattaatcaa 9240 ccttggatca aaaccatttc taagagaatg agagtagata tcattaatca ctctatagta 9300 acg cgtggaa aaagctctat attacaaact atagaaatta tttttactaa tagaacatgt 9360 gtgaaaatat tcaaggattc tactatgcac attattctat ccaaggacaa ggatgaaaag 9420 gggtgtatac acatgattga caaattattc tatgtctatt ataatttatt tctgttgttc 9480 gaggatatca tccaaaacga gtactttaaa gaagtagcta atgttgtaaa ccacgtactc 9540 acggctacgg cattagatga gaaattattc ctaattaaga aaatggctga acacgatgtt 9600 tatggagtta gcaatttcaa aatagggatg tttaacctga catttattaa gtcgttggat 9660 cataccgttt tcccctctct gttagatgag gatagcaaaa taaagttttt taaggggaaa 9720 aagctcaata ttgtagcatt acgatctctg gaggattgta taaattacgt gactaaatcc 9780 gagaatatga tagaaatgat gaaggaaaga tcgactattt taaatagcat agatatagaa 9840 acggaatcgg tagatcgtct aaaagaattg cttctaaaat gaaaaaaaaa cactaattca 9900 gaaatggatc aacgactcgg atataagttt ttggtgcctg atcctaaagc cggagttttt 9960 tatagaccgt tacatttcca atatgtatcg tattctaatt ttatattgca tcgattgcat 10020 gaaatcttga ccgtcaagcg gccactctta tcgtttaaga ataatacaga acgaattatg 10080 atagaaatta gcaatgttaa agtgactcct ccagattact cacctataat cgcgagtatt 10140 aaaggt aaga gttatgacgc attagccacg ttcactgtaa atatctttaa agaggtaatg 10200 accaaagagg gtatatccat cactaaaata agtagttatg agggaaaaga ttctcatttg 10260 ataaaaattc cgctactaat aggatacggg aataaaaatc cacttgatac agccaagtat 10320 cttgttccta atgtcatagg tggagtcttt atcaataaac aatctgtcga aaaagtagga 10380 attaatctag tagaaaagat tacaacatgg ccaaaattta gggttgttaa gccaaactca 10440 ttcactttct cgttttcctc cgtatcccct cctaatgtat taccgacaag atatcgccat 10500 tacaagatat ctctggatat atcacaattg gaagcgttga atatatcatc gacaaagaca 10560 tttataacgg tcaatattgt tttgctgtct caatatttat ctagagtgag tctagaattc 10620 attagacgta gtttatcata cgatatgcct ccagaagttg tctatctagt aaacgcgata 10680 atagatagtg ctaaacgaat tactgaatct attactgact ttaatattga tacatacatt 10740 aatgacctgg tggaagctga acacattaaa caaaaatctc agttaacgat caacgagttc 10800 aaatatgaaa tgctgcataa ctttttacct catatgaact atacacccga tcaactaaag 10860 ggattttata tgatatcttt actaagaaag tttctctact gtatctacca cacttctaga 10920 tatccagata gagattcgat ggtttgtcat cgcatcctaa cgtacggcaa atattttgag 1098 0 acgttggcac atgatgaatt agagaattac ataggcaaca tccgaaacga tatcatgaac 11040 aatcacaaga acagaggcac ttacgcggta aacattcatg tactaacaac tcctggactt 11100 aatcatgcat tttctagtct attgagtgga aagttcaaaa agtcagacgg tagttatcga 11160 acacatcctc actattcatg gatgcagaat atttctattc ctaggagtgt tggattttat 11220 ccggatcaag taaagatttc aaagatgttt tctgtcagaa aataccatcc aagtcaatat 11280 ctttactttt gttcatcgga cgttccggaa agaggtcctc aggtaggttt agtatctcaa 11340 ttgtctgtct tgagttccat tacaaatata ctaacgtctg agtatttgga tttggaaaag 11400 aaaatttgtg agtatatcag atcatattat aaagatgata taagttactt tgaaacagga 11460 tttccaatca ctatagaaaa tgctctagtc gcatctctta atccaaatat gatatgtgat 11520 tttgtaactg actttagacg tagaaaacgg atgggattct tcggtaactt ggaggtaggt 11580 attactttag ttagggatca catgaatgaa attcgcatta atattggagc gggaagatta 11640 gtcagaccat tcttggttgt ggataacgga gagctcatga tggatgtgtg tccggagtta 11700 gaaagcagat tagacgacat gacattctct gacattcaga aagagtttcc gcatgtcatc 11760 gaaatggtag atatagaaca atttactttt agtaacgtat gtgaatcggt tcaaaaa ttt 11820 agaatgatgt caaaggatga aagaaagcaa tacgatttat gtgactttcc tgccgaattt 11880 agagatggat atgtagcatc ttcactagtg ggaatcaatc acaattctgg acccagagct 11940 attcttggat gtgctcaagc taaacaagct atctcttgtc tgagctcgga tatacgaaat 12000 aaaatagaca atggaattca tttgatgtat ccagagaggc caatcgtgat tagtaaggct 12060 ttagaaactt caaagattgc ggctaattgc ttcggccaac atgttactat agcattaatg 12120 tcgtacaaag gtatcaatca agaggatgga attatcatca aaaaacaatt tattcagaga 12180 ggcggtctcg atattgttac agccaagaaa catcaagtag aaattccgtt ggaaaacttt 12240 aataacaaag aaagagatag gtctaacgcc tattcaaaat tagaaagtaa tggattagtt 12300 agactgaatg ctttcttgga atccggagac gctatagcac gaaatatctc atcaagaact 12360 cttgaagatg attttgctag agataatcag attagctttg atgtttccga aaaatatacc 12420 gatatgtaca aatctcgcgt tgaacgagta caagtagaac ttactgacaa agttaaggta 12480 cgagtattaa ccatgaaaga aagaagaccc attctaggag acaaatttac cactagaacg 12540 agtcaaaagg gaacagtcgc gtatatcgcg gatgaaacgg aacttccata cgatgaaaat 12600 ggtatcacac cagatgtcat tattaattct acatccatct tctctagaaa aactatatct 12660 atgttgatag aggttatttt aacagccgca tattctgcta agccgtacaa caataaggga 12720 gaaaaccgac ctgtctgttt tcctagtagt aacgaaacat ccatcgatac atatatgcaa 12780 ttcgctaaac aatgttatga gcattcaaat ccgaaattgt ctgatgaaga attatcggat 12840 aaaatctttt gtgaaaagat tctctatgat cctgaaacgg ataagcctta tgcatccaaa 12900 gtattttttg gaccaattta ttacttgcgt ctgaggcatt taactcagga caaggcaacc 12960 gttagatgta gaggtaaaaa gacgaagctc attagacagg cgaatgaggg acgaaaacgt 13020 ggaggaggta tcaagttcgg agaaatggag agagactgtt taatagcgca tggtgcagcc 13080 aatactatta cagaagtttt gaaagattcg gaagaagatt atcaagatgt gtatgtttgt 13140 gaaaattgtg gagacatagc agcacaaatc aagggtatta atacatgtct tagatgttca 13200 aaacttaatc tctctcctct cttaacaaaa attgatacca cgcacgtatc taaagtattt 13260 cttactcaaa tgaacgccag aggcgtaaaa gttaaattag atttcgaacg aaggcctcct 13320 tcgttttata aaccattaga taaagttgat ctcaaaccgt cttttctggt gtaatattct 13380 agtttggtag tagatacata tcaatatcat caaattcgag atccgaatta taaaatgggc 13440 gtggattgtt aactatagaa tcggacgtct gatattcgaa aa tctgtgga gttttaggtt 13500 ttggtggagg tgtaactgct acttgggata ctgaagtctg atattcagaa agctggggga 13560 tgttctggtt cgacatccac cgatggtgtc acatcactcactaa tcggtacatcggt tggct gacgtcattggt ttaggt gacgtcattggt 13620 gacctctgtgt acttcaatgc gaggaaatgt ataatttggt aatggtttct catgtggatc tgaagaagag 13740 gtaagatatc tactagaaag ataccgatca cgttctagtt ctcttttgta gaacttaact 13800 ttttctttct ccgcatctag ttgatattcc aacctcttca cgttcgcatg ggttacctcc 13860 gcagttttta cgagcgattt cacgttcagc cttcatgcgt cttatagcat gaattcgctt 13920 atcgttatcg ggtttagctt ctgtcacctt agcaattcct tttttattaa actctacata 13980 atcatatcca tttctattgt ttgttctaat ataaacgagt atagcatcat tgctaaattt 14040 ttcaatagta tcgaaaacag aatatcctaa accatataat atatattcag gaacactcaa 14100 actaaatgtc caggattctc ctaaatacgt aaactttaat agtgcgaaat cattcaaaaa 14160 tctaccactt atagatagat agatagtaca taaatgcgta tagtagtcta cctatctctt 14220 tattatgaaa accggcatta cgatcatata tgtcgtgata tacctgtgat ccgtttacgt 14280 taaaccataa atacatgggt gatcctataa acatgaattt atttctaatt ctcagagcta 14340 tagttaattg accgtgtaat atttgcttac atgcatactt gatacgatca ttaataagat 14400 ttttatcatt gctcgttatt tcagaatcgt atatataagg agtaccatcg tgattcttac 14460 cagatattat acaaaatact atatataaaa tatattgacc cacgttagta atcatgtaa a 14520 tgtttaacgt tttaaatttt gtattcaatg atccattatc atacgctagc atggtcttat 14580 gatattcatt ctttaaaata taatattgtg ttagccattg cattggggct cctaatggag 14640 attttttatt ctcatccatt ttaggatagg ctttcataaa gtccctaata acttcgtgaa 14700 taatgtttct atgttttcta ctgatgcatg tatttgcttc gattttttta tcccatgttt 14760 catctatcat agatttaaac gcagtaatgc tcgcaacatt aacatcttga accgttggta 14820 caattccgtt ccataaattt ataatgttcg ccatttatat aactcatttt ttgaatatac 14880 ttttaattaa caaaagagtt aagttactca tatggacgcc gtccagtctg aacatcaatc 14940 tttttagcca gagatatcat agccgctctt agagtttcag cgtgattttc caacctaaat 15000 agaacttcat cgttgcgttt acaacacttt tctatttgtt caaactttgt tgttacatta 15060 gtaatctttt tttccaaatt agttagccgt tgtttgagag tttcctcatt gtcgtcttca 15120 tcggctttaa caattgcttc gcgtttagcc tctggctttt tagcagccgt tgtagaaaaa 15180 aattcagttg ctggaattgc aagatcgtca tctccgggga aaagagttcc gtccatttaa 15240 agtacagatt ttagaaactg acactctgcg ttatttatat ttggtacaac acatggatta 15300 taaatattga tgttaataac atcagaaaat gtaaagtcta tacattgttg c atcgtgtta 15360 aattttctaa tggatctagt attattgggt ccaacttctg cctgaaatcc aaatatggaa 15420 gcggatacaa aaccgtttcc tggataaacc acacatctcc acttttgctt tacatcagaa 15480 attgtgtcgt tgacatcttg aactctccta tctaatgccg gtgttccacc tatagatttt 15540 gaatattcga atgctgcatg agtagcatta aattccttaa tattgccata attttcatat 15600 attgagtaac cctggataaa aagtaaacac accgcagccg tagctaccac aataaaaaaa 15660 attgatagag agttcattta taatctatta gaagctgaca aaattttttt acacgcatca 15720 gacaatgctt taataaatag ttcaacatct acttttgtca tatcgaaccg atggtatgat 15780 tctaacctag aattacatcc gaaaaagttg actatgttca tagtcattaa gtcattaaca 15840 aacaacattc cagactctgg attataagac gatactgttt cgtcacaatt acctacctta 15900 atcatgtgat tatgaatatt ggctattaga gcaccttcta agaaatctat aatatctttg 15960 aaacacgatt taaaatcaaa ccacgaatat acttctacga agaaagttag tttacccata 16020 ggagaaataa ctataaatgg agatctaaat acaaaatccg gatctatgat agttttaaca 16080 ttattatatt ctctattaaa tacctccaca tctaaaaatg ttaattttga aactatgtct 16140 tcgtttatta ccgtacctga actaaacgct ataagctcta ttgt ttgaga actctttaaa 16200 cgatattctt gaaatacatg taacaaagtt tcctttaact cggtcggttt atctaccata 16260 gttacagaat ttgtatcctt atctataata taataatcaa aatcgtataa agttatataa 16320 ttatcgcgtt cagattggga tcttttcaaa tagactaaaa accccatttc tctagtaagt 16380 atcttatgta tatgtttgta aaatatcttc atggtgggaa tatgctctac cgcagttagc 16440 cattcctcat tgacagcggt agatgtatta gacaaaacta ttccaatgtt taacaagggc 16500 cattttacga gattattaaa tccttgtttg ataaatgtag ccaatgaggg ttcgagttca 16560 acgacgattg aattctcttc ccgcggatgc tgcatgatga acgacgggat gttgttcgat 16620 tgatttggaa ttctttttcg actttttgtt tatattaaat attttaaaat ttatagcgga 16680 tagcaattca tgtaccacgg ataatgtaga cgcgtattgc gcatcgatat ctttattatt 16740 agataaattt atcaataaat gtgagaagtt tgcctcgtta aggtcttcca tttaaatatt 16800 atataaacat ttgtgtttgt atcttattcg tcttttatgg aatagttttt tactagtaaa 16860 gctgcaatta cacactttgt ccgtaaaaca taaatataaa caccagcttt tatcaatcgt 16920 tccaaaaagt cgacggcgga catttttaac atggcatcta ttttaaatac acttaggttt 16980 ttggaaaaaa catcatttta taattgtaac gattcaa taa ctaaagaaaa gattaagatt 17040 aaacataagg gaatgtcatt tgtattttat aagccaaagc attctaccgt tgttaaatac 17100 ttgtctggag gaggtatata tcatgatgat ttggttgtat tggggaaggt aacaattaat 17160 gatctaaaga tgatgctatt ttacatggat ttatcatatc atggagtgac aagtagtgga 17220 acaatttaca aattgggatc gtctatcgat agactttctc taaataggac tattgttaca 17280 aaagttaata attataatta tgatacattt tttgacgatg atgattgatc gctattgcac 17340 aattttgttt ttttactttc taatatagcg tttagattct ttttcatgtg cgaatattga 17400 tttactaaaa tatctatgtt taacttttgt tctataacgt ccttatcggc ggtatcggta 17460 catatacgta attcaccttc acaaaatacg gagtcttcga taataatagc caatcgatta 17520 ttggatctag ctgtctgtat catattcaac atgtttaata tatcctttcg tttccccttt 17580 acaggcatcg atcgtagcat attttccgcg tctgagatgg aaatgttaaa actacaaaaa 17640 tgcgtaatgt tagcccgtcc taatattggt acgtgtctat aagtttggca tagtagaata 17700 atagacgtgt ttaaatgcct tccaaagttt aagaattcta ttagagtatt gcattttgat 17760 agtttatcgc ctacatcatc aaaaataagt aaaaagtgtg ctgatttttt atgattttgt 17820 gcgacagcaa tacatttttc tatgttactt ttagttcgta tcagattata ttctagagat 17880 tcctgactac taacgaaatt aatatgattt ggccaaatgt atccatcata atctggatta 17940 taaacgggtg taaacaagaa tacatgttta tattttttaa ctagtgtaga aaacagagat 18000 agtaaataga tagtttttcc agatccagat cctcccgtta aaaccattct aaacggcatt 18060 tttaataaat tttctcttga aaattgtttt tcttggaaac aattcataat tatatttaca 18120 gttactaaat taatttgata ataaatcaaa atatggaaaa ctaaggtcgt tagtagggag 18180 gagaacaaag aaggcacatc gtgacataaa taacatttat tatcatgatg acaccagaaa 18240 acgacgaaga gcagacatct gtgttctccg ctactgttta cagagacaaa attcagggaa 18300 agaataaacg caaacgcgtg attggtctat gtattagaat atctatggtt atttcactac 18360 tatctatgat taccatgtcc gcgtttctca tagtgcgcct aaatcaatgc atgtctgcta 18420 acgaggctgc tattactgac gccgctgttg ccgttgctgc tgcatcatct actcatagaa 18480 aggttgcgtc tagcactacg caatatgatc acaaagaaag ctgtaatggt ttatattacc 18540 agggttcttg ttatatatta cattcagact accagttatt ctcggatgct aaagcaaatt 18600 gcactgcgga atcatcaaca ctacccaata aatccgatgt cttgactacc tggctcattg 18660 attatgttaa ggatacatgg gg atctgatg gtaatccaat tacaaaaact acatccgatt 18720 atcaagattc tgatgtatca caagaagtta gaaagtattt ttgtgttaaa acaatgaact 18780 aatatttatt tttgtacatt aataaatgaa atcgcttaat agacaaactg taagtaggtt 18840 taagaagttg tcggtgccgg tcgctataat gatgatactc tcaaccatta ttagtggcat 18900 aggaacattt ctgcattaca aagaagaact gatgcctagt gcttgcgcca atggatggat 18960 acaatacgat aaacattgtt atttagatac taacattaaa atgtctacag ataatgcggt 19020 ttatcagtgt cgtaaattac gagccagatt gcctagaccg gatactagac atctgagagt 19080 attgtttagt attttttata aagattattg ggtaagttta aaaaagacca atgataaatg 19140 gttagatatt aataatgata aagatataga tattagtaaa ttaacaaatt ttaaacaact 19200 aaacagtacg acggatgctg aagcgtgtta tatatacaag tctggaaaac tggttaaaac 19260 agtatgtaaa agtactcaat ctgtactatg tgttaaaaaa ttctacaagt gacaacaaaa 19320 aatgaattaa taataagtcg ttaacgtacg ccgccatgga cgccgcgttt gttattactc 19380 caatgggtgt gttgactata acagatacat tgtatgatga tctcgatatc tcaatcatgg 19440 actttatagg accatacatt ataggtaaca taaaaactgt ccaaatagat gtacgggata 19500 taaaatattc cgaca tgcaa aaatgctact ttagctataa gggtaaaata gttcctcagg 19560 attctaatga tttggctaga ttcaacattt atagcatttg tgccgcatac agatcaaaaa 19620 ataccatcat catagcatgc gactatgata tcatgttaga tatagaagat aaacatcagc 19680 cattttatct attcccatct attgatgttt ttaacgctac aatcatagaa gcgtataacc 19740 tgtatacagc tggagattat catctaatca tcaatccttc agataatctg aaaatgaaat 19800 tgtcgtttaa ttcttcattc tgcatatcag acggcaatgg atggatcata attgatggga 19860 aatgcaatag taatttttta tcataaaagt tgtaaagtaa ataataaaac aataaatatt 19920 gaactagtag tacgtatatt gagcaatcag aaatgatgct ggtacctctt atcacggtga 19980 ccgtagttgc gggaacaata ttagtatgtt atatattata tatttgtagg aaaaagatac 20040 gtactgtcta taatgacaat aaaattatca tgacaaaatt aaaaaagata aagagttcta 20100 attccagcaa atctagtaaa tcaactgata gcgaatcaga ctgggaggat cactgtagtg 20160 ctatggaaca aaacaatgac gtagataata tttctaggaa tgagatattg gacgatgata 20220 gcttcgctgg tagtttaata tgggataacg aatccaatgt tatggcgcct agcacagaac 20280 acatttacga tagtgttgct ggaagcacgc tgctaataaa taatgatcgt aatgaacaga 20340 ctatttat ca gaacactaca gtagtactta atgaagatac caaacagaat cctaactatt 20400 catccaatcc tttcgtaaat tataataaaa ccagtatttg tagcaagtca aatccgttca 20460 ttacagaact caacaataaa tttagtgaga ataatccgtt tagacgagca catagcgatg 20520 attatcttaa taagcaagaa caagatcatg aacacgatga tatagaatca ttggtgtgat 20580 tagtttcctt tttataaaat tgaagtaata tttagtatta ttgctgccgt cacgttgtac 20640 aaatggagat attccctgta ttcggcattt ctaaaattag caattttatt gctaataatg 20700 actgtagata ttatatagat acagaacatc aaaaaattat atctgatgag atcaatagac 20760 agatggatga aacggtactt cttaccaaca tcttaagcgt agaagttgta aatgacaatg 20820 agatgtacca tcttattcct catagattat cgacgattat actctgtatt agttctgtcg 20880 gaggatgtgt tatctctata gataatgacg tcaatggcaa aaatattcta acctttccca 20940 ttgatcatgc tgtaatcata tccccactga gtaaatgtgt cgtagttagc aagggtccta 21000 caaccatatt ggttgttaaa gcggatatac ctagcaaacg attggtaaca tcgtttacaa 21060 acgacatact gtatgtaaac aatctatcac tgattaatta ttcgccgttg tctgtattca 21120 ttattagacg agttaccgac tatttggata gacacatatg cgatcagata tttgcgaata 21180 ataagtggta ttccattata accatcgaca ataagcagtt tcctattcca tcaaactgta 21240 taggtatgtc ctctgccaag tacataaatt ctagcatcga gcaagatact ttaatacatg 21300 tttgtaacct cgagcatcca ttcgacttag tatacaaaaa aatgcagtcg tacaattctg 21360 tacctatcaa ggaacaaata ttgtacggta gaattgataa tataaatatg agcattagta 21420 tttctgtgga ttaatagatt tctagtatgg ggatcattaa tcatctctaa tctctaaata 21480 cctcataaaa cgaaaaaaaa gctattatca aatactgtac ggaatggatt cattctcttc 21540 tctttttatg aaactctgtt gtatatctac tgataaaact ggaagcaaaa aatctgataa 21600 aaagaataag aataagatca aggattatta taaaataaca atagttcctg gttcctcttc 21660 cacgtctact agctcgtggt attatacaca tgcctagtaa tagtctcttt gcgttgacgg 21720 aaagcagact agaaataaca ggctaaaatg ttcagacacc ataatagttc ccaacccaga 21780 taataacaga gtaccatcaa cacattcctt taaactcaat cccaaaccca aaaccgttaa 21840 aatgtatccg gccaattgat agtagataat gaggtgtaca gcgcatgatg atttacacag 21900 taaccaaaat gaaaatactt tagtaattat aagaaatata gatggtaacg tcatcatcaa 21960 caatccaata atatgccgga gagtaaacat tgacggataa aacaaaaatg ctccgcata a 22020 ctctatcatg gcaataacac aaccaaatac ttgtaagatt cctaaattag tagaaaatac 22080 aacggatatc gatgtataag tgatctcgag aaataataag aataaagtaa tgcccgtaaa 22140 gataaacatc aacattgttt ggtaatcatt aaaccaatta gtatgaagtt gaactaattt 22200 cacagtagat tttattccag tattatcccc gcatgtataa gtacctggta agatatcttt 22260 atattccata atcaatgaga catcactatc tgataacgaa tgaagtctag cactagtatg 22320 ccatttactt aatattgtcg tcttggaagt tttattataa gttaaaatat catggttatc 22380 caatttccat ctaatatact ttgtcggatt atctatagta cacggaataa tgatggtatc 22440 attacatgct gtatactcta tggtctttgt agttgttata acaaccaacg tatagaggta 22500 tatcaacgat attctaactc ttgacatttt ttatttattt aaaatgatac ctttgttatt 22560 tattttattc tattttgcta acggtattga atggcataag tttgaaacga gtgaagaaat 22620 aatttctact tacttattag acgacgtatt atacacgggt gttaatgggg cggtatacac 22680 attttcaaat aataaactaa acaaaactgg tttaactaat aataattata taacaacatc 22740 tataaaagta gaggatgcgg aaccaataac ggaaatccca aatgttggaa aatagacggt 22800 tcagacgacc caaaacatag aggtagagga tacgctcctt atcaaaatag c aaagtaacg 22860 ataatcagtc acaacggatg tgtactatct gacataaaca tatcaaaaga aggaattaaa 22920 cgatggagaa gatttgacgg accatgtggt tatgatttat acacggcgga taacgtaatt 22980 ccaaaagatg gtttacgagg agcattcgtc gataaagatg gtacttatga caaagtttac 23040 attcttttca ctgatactat cggctcaaag agaattgtca aaattccgta tatagcacaa 23100 atgtgcctaa acgacgaagg tggtccatca tcattgtcta gtcatagatg gtcgacgttt 23160 ctcaaagtcg aattagaatg tgatatcgac ggaagaagtt atagacaaat tattcattct 23220 agaactataa aaacagataa tgatacgata ctatatgtat tcttcgatag tccttattcc 23280 aagtccgcat tatgtaccta ttctatgaat accattaaac aatctttttc tacgtcaaaa 23340 ttggaaggat atacaaagca attgccgtct ccagctcctg gtatatgttt accagctgga 23400 aaagttgttc cacataccac gtttgaagtc atagaaaaat ataatgtact agatgatatt 23460 ataaagcctt tatctaacca acctatcttc gaaggaccgt ctggtgttaa atggttcgat 23520 ataaaggaga aggaaaatga acatcgggaa tatagaatat acttcataaa agaaaattct 23580 atatattcgt tcgatacaaa atctaaacaa actcgtagct cgcaagtcga tgcgcgacta 23640 ttttcagtaa tggtaacttc gaaaccgtta tttatagcag atat agggat aggagtagga 23700 atgccacaaa tgaaaaaaat acttaaaatg taatcttaat cgagtacacc gcacgacaat 23760 gaacaaacat aagacagatt atgctggtta tgcttgctgc gtaatatgcg gtctaattgt 23820 tggaattatt tttacagcga cactattaaa agttgtagaa cgtaaattag ttcatacacc 23880 atcaatagat aaaacgataa aagatgcata tattagagaa gattgtccta ctgactggat 23940 aagctataat aataaatgta tccatttatc tactgatcga aaaacctggg aggaaggacg 24000 taatgcatgc aaagctctaa atccaaattc ggatctaatt aagatagaga ctccaaacga 24060 gttaagtttt ttaagaagca ttagacgcgg atattgggta ggagaatccg aaatattaaa 24120 ccagacaacc ccatataatt ttatagctaa aaatgccacg aagaatggaa ctaaaaaacg 24180 gaaatatatt tgtagtacaa cgaatactcc caaactacat ttttatcata ccactacttc 24240 ggttagatgt tttagaaaaa aataaatatc gccgtaccgt tcttgttttt ataaaaataa 24300 caattaacaa ttatcaaatt ttttctttaa tattttacgt ggttgaccat tcttggtggt 24360 aaaataatct cttagtgttg gaatggaatg ctgtttaatg tttccgcact catcgtatat 24420 tttgacgtat gcagtcacat cgtttacgca atagtcagac tgtagttcta tcatgcttcc 24480 tacatcagaa ggaggaacag ttttaaagtc tcttggt ttt aatctattgc cattagtttt 24540 catgaaatcc tttgttttat ccacttcaca ttttaaataa atgtccacta tacattcttc 24600 tgttaatttt actagatcgt catgggtcat agaatttata ggttccgtag tccatggatc 24660 caaactagca aacttcgcgt atacggtatc gcgattagtg tatacaccaa ctgtatgaaa 24720 attaagaaaa cagtttaata aatcaacaga aatatttaat cctccgtttg atacagatgc 24780 gccatattta tggatttcgg attcacacgt tgtttgtctg aggtgttcgt ctagtgttgc 24840 ttctacgtaa acttcgattc ccatatattc tttattgtca gaatcgcata ccgatttatc 24900 atcatacact gtttgaaaac taaatggtat acacatcaaa ataataaata ataacgagta 24960 cattctgcaa tattgttatc gtaattggaa aaatagtgtt cgagtgagtt ggattatgtg 25020 agtattggat tgtatatttt attttatatt ttatattttg tagtaagaat agaatgctaa 25080 tgtcaagttt attccaatag atgtcttatt aaaaaacata tataataaat aacaatggct 25140 gaatggcata aaattatcga ggatatctca aaaaataata agttcgagga tgccgccatc 25200 gttgattaca agactacaaa gaatgttcta gctgctattc ctaacagaac atttgccaag 25260 attaatcctc tcatcactaa tcgtaatatt ctaaaacctc ttattggtca gaaatattgt 25320 attgtatata ctaactctct aatggatgag aacacgtatg ctatggagtt gcttactggg 25380 tacgcccctg tatctccgat cgttatagcg agaactcata ccgcacttat atttttgatg 25440 ggtaagccaa caacatccag acgtgacgtg tatagaacgt gtagagatca cgctacccgt 25500 gtacgtgcaa ctggtaatta aaataaaaag taatattcat atgtagtgtc aattttaaat 25560 gatgatgatg aaatggataa tatccatatt gacgatgtca ataatgccgg tattggcata 25620 cagttcatcg atttttagat ttcattcaga ggatgtggaa ttatgttatg ggcatttgta 25680 ttttgatagg atctataatg tagtaaatat aaaatataat ccgcatattc catatagata 25740 taattttatt aatcgcacgt taaccgtaga tgaactagac gataatgtct tttttacaca 25800 tggttatttt ttaaaacaca aatatggttc acttaatcct agtttgattg tctcattatc 25860 aggaaactta aaatataatg atatacaatg ctcagtaaat gtatcgtgtc tcattaaaaa 25920 tttggcaacg agtacatcta ctatattaac atctaaacat aagacttatt ctctacatcg 25980 gtccacgtgt attactataa taggatacga ttctattata tggtataaag atataaatga 26040 catctatgat tttactgcaa tatgtatgct aatagcgtct acattgatag tgaccatata 26100 cgtgtttaaa aaaataaaaa tgaactctta attatgctat gctattagaa atggataaaa 26160 tcaaaattac ggttgattca aa aattggta atgttgttac catatcgtat aacttggaaa 26220 agataactat tgatgtcaca cctaaaaaga aaaaagaaaa ggatgtatta ttagcgcaat 26280 cagttgctgt cgaagaggca aaagatgtca aggtagaaga aaaaaatatt atcgatattg 26340 aagatgacga tgatatggat gtagaaagcg cataatacga tctataaaaa taagtatata 26400 aatacttttt atttactgta ctcttactgt gtagtggtga taccctactc gattattttt 26460 ttaaaaaaaa atacttattc tgattcttct agccatttcc gtgttcgttc gaatgccaca 26520 tcgacgttaa agatagggga gtagttgaaa tctagttctg cattgttggt acgcacctca 26580 aatgtagtgt tggatatctt caacgtatag ttgttgagta gtgatggttt tctaaataga 26640 attctcttca tatcattctt gcacgcgtac atttttagca tccatcttgg aatcctagat 26700 ccttgttcta ttcccaatgg tttcatcaat agaagattaa acatatcgta cgaacacgat 26760 ggagagtaat cgtagcaaaa gtaagcattt cctttaatct cagatcccgg atactggata 26820 tattttgcag ccaacacgtg catccatgca gcatttccta catatacccg gctatgtacc 26880 gcgttatcat cgactgtacg atacataatg ttaccgtgtt gcttacattg ctcgtaaaag 26940 actttcatca atttgtctcc ttctccgtaa attccagtgg gtcttaggca acaagtatac 27000 aattttgctc cattc atgat tacggaatta ttggctttca taaccagttg ctcggccata 27060 cgtttacttt ttgcgtatac atgtcctggt gatatatcat aaagggtatg ctcatggccg 27120 atgaatggat caccgtgttt attgggtcct attgcttcca tgctactagt atagatcaaa 27180 tacttgattc ctaggtccac acaagctgcc aatatagtct gtgttccata atagtttact 27240 ttcatgattt cattatcggt gtattttcca aatacatcca ctagagcagc tgtatgaata 27300 atcagattta ccccatctag cgcttctctt accttatcaa agtcgtttat atcacattgt 27360 atatagttta taaccttaac tttcgaggtt attggttgtg gatcttctac aatatctatg 27420 actctgattt cttgaacatc atctgcacta attaacagtt ttactatata cctgcctaga 27480 aatccggcac caccagtaac cgcgtacacg gccattgctg ccactcataa tatcagacta 27540 cttattctat tttactaaat aatggctgtt tgtataatag accacgataa tatcagagga 27600 gttatttact ttgaaccagt ccatggaaaa gataaagtta ttggattaaa atccggaacg 27660 tatagtttga taattcatcg ttacggagat attagtcaag gatgtgattc cataggcagt 27720 ccagaaatat ttatcggtaa catctttgta aacagatatg gtgtagcata tgtttattta 27780 gatacagatg taaatatatc tacaattatt ggaaaggcgt tatctatttc aaaaaatgat 27840 cagagattag cgtgtggagt tattggtatt tcttacataa atgaaaagat aatacatttt 27900 cttacaatta acgagaatgg cgtttgatat atcagttaat gcgtctaaaa caataaatgc 27960 attagtttac ttttctactc agcaaaataa attagtcata cgtaatgaag ttaatgatac 28020 acactacact gtcgaatttg atagggacaa agtagttgac acgtttattt catataata g 28080 acataatgac tccatagaga taagaggggt gcttccagag gaaactaata ttggttgcgc 28140 ggttaatacg ccggttagta tgacttactt gtataataag tatagtttta aactgatttt 28200 agcagaatat ataagacaca gaaatactat atccggcaat atttattcgg cattgatgac 28260 actagatgat ttggctatta aacagtatgg agacattgat ctattattta atgagaaact 28320 taaagtagac tccgattcgg gactatttga ctttgtcaac tttgtaaagg atatgatatg 28380 ttgtgattct agaatagtag tagctctatc tagtctagta tctaaacatt gggaattgac 28440 aaataaaaaa tataggtgta tggcattagc cgaacatata tctgatagta ttccaatatc 28500 tgagctatct agactacgat acaatctatg taagtatcta cgcgggcaca ctgagagcat 28560 agaggatgaa tttgattatt ttgaagacga tgattcgtct acatgttctg ccgtaaccga 28620 cagggaaacg gatgtataat tttttttata gcgtgaagga tatgataaaa aatataattg 28680 ttgtatttat cccattccaa tcaccttata tgattctgta acacaatgaa ggagtcttat 28740 agatgtatag aggtcagata ctggtttgat aaactgttta ttccacataa gtatgtttga 28800 ctttatggtt agacccgcat actttaacaa atcactgaaa attggagtta ggtattgacc 28860 tctcagaatc agttgccgtt ctggaacatt aaatgtattt tttatgatat a ctccaacgc 28920 atttatgtgg gcatacaaca agtcattact aatggagtat tccaagagaa gagatttcaa 28980 cagactgttt atgaactcga atgccgcctc attgtcgctt atattgatga tgtcgaattc 29040 tcccaatatc atcaccgatg agtagctcat cttgttatcg ggatccaagt tttctaaaga 29100 tgtcattaaa ccctcgatca tgaatggatt tatcatcatc gtttttatgt tggacatgag 29160 cttagtccgt ttgtccacat ctatagacga cgatttctga attatttcat atatccctct 29220 ctttaactcc aggaacttgt caggatggtc tactttaata tgttctcgtc taagagatga 29280 aaatctttgg atggttgcac gcgacttttc tctaaaggat cctctcttaa atgaatccat 29340 cttatccttg gacaagatgg acagtctatt ttccttagat ggtttaatat ttttgttacc 29400 catgatctat aaaggtagac ctaatcgtct cggatgacca tatatttatt ttcagtttta 29460 ttatacgcat aaattgtaaa aaatatgtta ggtttacaaa aatgtctcgt ggggcattaa 29520 tcgtttttga aggattggac aaatctggaa aaacaacaca atgtatgaac atcatggaat 29580 ctataccggc aaacacgata aaatatctta actttcctca gagatccact gtcactggaa 29640 agatgataga tgactatcta actcgtaaaa aaacctataa tgatcatata gttaatctat 29700 tattttgtgc aaatagatgg gagtttgcat cttttataca agaa caacta gaacagggaa 29760 ttactttaat agttgataga tacgcattct ctggagtagc gtatgccgcc gctaaaggcg 29820 cgtcaatgac tctcagtaag agttatgaat ctggattgcc taaacccgac ttagttatat 29880 tcttggaatc tggtagcaaa gaaattaata gaaacgtcgg cgaggaaatt tatgaagatg 29940 ttacattcca acaaaaggta ttacaagaat ataaaaaaat gattgaagaa ggagatattc 30000 attggcaaat tatttcttct gaattcgagg aagatgtaaa gaaggagttg attaagaata 30060 tagttataga ggctatacac acggttactg gaccagtggg gcaactgtgg atgtaatagt 30120 gaaattacat tttttataaa tggatgaagc atattactct ggcaacttgg aatcagtact 30180 cggatacgtg tccgatatgc ataccgaact cgcatcaata tctcaattag ttattgccaa 30240 gatagaaact atagataatg atatattaaa caaggacatt gtaaatttta tcatgtgtag 30300 atcaaacttg gataatccat ttatctcttt cctagatact gtatatacta ttatagatca 30360 agagatctat cagaccgaat tgattaattc attagacgac aatgaaatta tcgattgtat 30420 agttaacaag tttatgagct tttataagga taacctagaa aatatagtag atgctatcat 30480 tactctaaaa tatataatga ataatccaga ttttaaaact acgtatgccg aagtactcgg 30540 ttccagaata gcggatatag atattaaaca agtgata cgt gagaatatac tacaattgtc 30600 taataatatc cgcgaacgat atttgtgaaa atattaaaaa aaaatacttt ttttattaaa 30660 tgacgtcgct tcgcgaattt agaaaattat gctgtgatat atatcacgca tcaggatata 30720 aagaaaaatc taaattaatt agagacttta taacagatag ggatgataaa tatttgatca 30780 ttaagctatt gcttcccgga ttagacgata gaatttataa catgaacgat aaacaaatta 30840 taaaattata tagtataata tttaaacaat ctcaggaaga tatgctacaa gatttaggat 30900 acggatatat aggagacact attaggactt tcttcaaaga gaacacagaa atccgtccac 30960 gagataaaag cattttaact ttagaagaag tggatagttt tttaactacg ttatcatccg 31020 taactaaaga atcgcatcaa ataaaattat tgactgatat cgcatccgtt tgtacatgta 31080 atgatttaaa atgtgtagtc atgcttattg ataaagatct aaaaattaaa gcgggccctc 31140 ggtacgtact taacgctatt agtcctcatg cctatgatgt gtttagaaaa tctaataact 31200 tgaaagagat aatagaaaat gcatctaaac aaaatctaga ctctatatct atttctgtta 31260 tgactccaat taatcccatg ttagcggaat cgtgtgattc tgtcaataag gcgtttaaaa 31320 aatttccatc aggaatgttt gcggaagtca aatacgatgg tgaaagagta caagttcata 31380 aaaataataa cgagtttgcc ttctttagta gaaacatgaa accagtactc tctcataaag 31440 tggattatct caaagaatac ataccgaaag catttaaaaa agctacgtct atcgtattgg 31500 attctgaaat tgttcttgta gacgaacata atgtaccgct cccgtttgga agtttaggta 31560 tacacaaaaa gaaagaatat aaaaactcta acatgtgttt gttcgtgttt gactgtttgt 31620 actttgatgg attcgatatg acggacattc cattgtacga acgaagatct tttctcaaag 31680 atgttatggt tgaaataccc aatagaatag tattctcaga gttgacgaat attagtaacg 31740 agtctcagtt aactgacgta ttggatgatg cactaacgag aaaattagaa ggattggtct 31800 taaaagatat taatggagta tacgaaccgg gaaagagaag atggttaaaa ataaagcgag 31860 actatttgaa cgagggttcc atggcagatt ctgccgattt agtagtacta ggtgcttact 31920 atggtaaagg agcaaagggt ggtatcatgg cagtctttct aatgggttgt tacgacgatg 31980 aatccggtaa atggaagacg gttaccaagt gttcaggaca cgatgataat acgttaaggg 32040 agttgcaaga ccaattaaag atgattaaaa ttaacaagga tcccaaaaaa attccagagt 32100 ggttagtagt taataaaatc tatattcccg attttgtagt agaggatcca aaacaatctc 32160 agatatggga aatttcagga gcagagttta catcttccaa gtcccatacc gcaaatggaa 32220 tatccattag atttcctaga tt tactagga taagagagga taaaacgtgg aaagaatcta 32280 ctcatctaaa cgatttagta aacttgacta aatcttaata gttacataca aattaaaata 32340 acactattta gttggtggtc gccatggatg gtgttattgt atactgtcta aacgcgttag 32400 taaaacatgg cgaggaaata aatcatataa aaaatgattt catgattaaa ccatgttgtg 32460 aaaaagtcaa gaacgttcac attggcggac aatctaaaaa caatacagtg attgcagatt 32520 tgccatatat ggataatgcg gtatccgatg tatgcaattc actgtataaa aagaatgtat 32580 caagaatatc cagatttgct aatttgataa agatagatga cgatgacaag actcctactg 32640 gtgtatataa ttattttaaa cctaaagatg ccattcctgt tattatatcc ataggaaagg 32700 atagagatgt ttgtgaacta ttaatctcat ctgataaagc gtgtgcgtgt atagagttaa 32760 attcatataa agtagccatt cttcccatgg atgtttcctt ttttaccaaa ggaaatgcat 32820 cattgattat tctcctgttt gatttctcta tcgatgcggc acctctctta agaagtgtaa 32880 ccgataataa tgttattata tctagacacc agcgtctaca tgacgagctt ccgagttcca 32940 attggttcaa gttttacata agtataaagt ccgactattg ttctatatta tatatggttg 33000 ttgatggatc tgtgatgcat gcaatagctg ataatagaac ttacgcaaat attagcaaaa 33060 atatattaga caata ctaca attaacgatg agtgtagatg ctgttatttt gaaccacaga 33120 ttaggattct tgatagagat gagatgctca atggatcatc gtgtgatatg aacagacatt 33180 gtattatgat gaatttacct gatgtaggcg aatttggatc tagtatgttg gggaaatatg 33240 aacctgacat gattaagatt gctctttcgg tggctggtat ttggaaagtt ttataggtag 33300 ttgatagaac aaaatacata attttgtaaa aataaatcac tttttatact aatatgacac 33360 gattaccaat acttttgtta ctaatatcat tagtatacgc tacacctttt cctcagacat 33420 ctaaaaaaat aggtgatgat gcaactttat catgtaatcg aaataataca aatgactacg 33480 ttgttatgag tgcttggtat aaggagccca attccattat tcttttagct gctaaaagcg 33540 acgtcttgta ttttgataat tataccaagg ataaaatatc ttacgactct ccatacgatg 33600 atctagttac aactatcaca attaaatcat tgactgctag agatgccggt acttatgtat 33660 gtgcattctt tatgacatcg cctacaaatg acactgataa agtagattat gaagaatact 33720 ccacagagtt gattgtaaat acagatagtg aatcgactat agacataata ctatctggat 33780 ctacacattc accggaaact agttctgaga aacctgatta tatagataat tctaattgct 33840 cgtcggtatt cgaaatcgcg actccggaac caattactga taatgtagaa gatcatacag 33900 acaccgtc ac atacactagt gatagcatta atacagtaag tgcatcatct ggagaatcca 33960 caacagacga gactccggaa ccaattactg ataaagaaga agatcataca gttacagaca 34020 ctgtctcata cactacagta agtacatcat ctggaattgt cactactaaa tcaaccaccg 34080 atgatgcgga tctttatgat acgtacaatg ataatgatac agtaccatca actactgtag 34140 gcggtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa atatttggta 34200 ttaccgcatt aattatattg tcggccgtgg caatattctg tattacatat tatatatata 34260 ataaacgttc acgtaaatac aaaacagaga acaaagtcta gatttttgac ttacataaat 34320 gtctgggata gtaaaatcta tcatattgag cgggccatct ggtttaggaa agacagccat 34380 agccaaaaga ctatgggaat atatttggat ttgtggtgtc ccataccact agatttcctc 34440 gtcctatgga acgagaaggt gtcgattacc attacgttaa cagagaggcc atctggaagg 34500 gaatagccgc cggaacatac tgagttttta ggaaatattt acggaacttc taaaactgct 34560 gtgaatacag cggctattaa taatcgtatt tgtgtgatgg atctaaacat cgacggtgtt 34620 agaagtttta aaaatactta cctaatgcct tactcggtgt atataagacc tacctctctt 34680 aaaatggttg agaccaagct tcgttgtaga aacactgaag cggatgatga gattcatcgt 34740 cgtgtgatgt tggcaaaaac tgacatggat gaggcaggtg aagccggtct attcgacact 34800 attatcattg aagatgatgt gaatttagca tatagtaagt taattcagat actacaggac 34860 cgtattagaa tgtattttaa cactaattag agacttaaga cttaaaactt gataattaat 34920 aatataactc gtttttatat gtggctattt caacgtctaa tgtattagtt aaatattaaa 34980 acttaccacg taaaacttaa aatttaaaat gatatttcat tgacagatag atcacacatt 35040 atgaactttc aaggacttgt gttaactgac aattgcaaaa atcaatgggt cgttggacca 35100 ttaataggaa aaggtggatt tggtagtatt tatactacta atgacaataa ttatgtagta 35160 aaaatagagc ccaaagctaa cggatcatta tttaccgaac aggcatttta tactagagta 35220 cttaaaccat ccgttatcga agaatggaaa aaatctcaca atataaagca cgtaggtctt 35280 atcacgtgca aggcatttgg tctatacaaa tccattaatg tggaatatcg attcttggta 35340 attaatagat taggtgcaga tctagatgcg gtgatcagag ccaataataa tagattacca 35400 aaaaggtcgg tgatgttgat cggaatcgaa atcttaaata ccatacaatt tatgcacgag 35460 caaggatatt ctcacggaga tattaaagcg agtaatatag tcttggatca aatagataag 35520 aataaattat atctagtgga ttacggattg gtttctaaat tcatgtctaa tggcgaaca t 35580 gttccattta taagaaatcc aaataaaatg gataacggta ctctagaatt tacacctata 35640 gattcgcata aaggatacgt tgtatctaga cgtggagatc tagaaacact tggatattgt 35700 atgattagat ggttgggagg tatcttgcca tggactaaga tatctgaaac aaagaattgt 35760 gcattagtaa gtgccacaaa acagaaatat gttaacaata ctgcgacttt gttaatgacc 35820 agtttgcaat atgcacctag agaattgctg caatatatta ccatggtaaa ctctttgaca 35880 tattttgagg aacccaatta cgacaagttt cggcacatat taatgcaggg tgtatattat 35940 taagtgtggt gtttggttga tgtaaaattt ttgtcgataa aaattaaaaa ataacttaat 36000 ttattattga tctcgtgtgt acaaccgaaa tcatggcgat gttttacgca cacgctctcg 36060 gtgggtacga cgagaatctt catgcctttc ctggaatatc atcgactgtt gccaatgatg 36120 tcagtttata ataacaagta tgacattgta aaagacaaat atatgtggtg ttacagtcag 36180 gtgaacaaga gatatattgg agcactgctg cctatgtttg agtgcaatga atatctacaa 36240 attggagatc cgatccatga tcaagaagga aatcacatat cgccacaaaa actactatgc 36300 tctaagcgga atcgggtacg agagtctaga cttgtgtttg gaaggagtag ggattcatca 36360 tcacgtactt gaaacagaaa acgctgtata tggaaaagtt caacatgatt a ttctactat 36420 caaagagaag gccaaagaaa tgaatgcact cagttcagga cctatcatcg attaccacgt 36480 ctggatagga gattgtatct gtcaagttac tgctgtggac gtacatggaa aggaaattat 36540 gagaatgaga ttcaaaaagg gtgcggtgct tccgatccca aatctggtaa aagttaaact 36600 tggggagaat gatacagaaa atctttcttc tactatatcg gcggcaccat cgaggtaacc 36660 acctctctgg aagacagtgt gaatcatgta ctcatgaaac gtttggaatc tatacgccat 36720 atgtggtctg ttgtatatga tcattttgat attgtgaatg gtaaagaatg ctgttatgtg 36780 catacgcatt tgtctaatca aaatcttata ccgagtactg taaaaacaaa tttgtacatg 36840 aagactatgg gatcatgcat tcaaatgagt atcttagcga actgaaggaa tcaggtggat 36900 ggagtcccag accagaaatg caggaatttg aatatccaga tggagtggaa gacactgaat 36960 caattgagag attggtagag gagttcttca atagatcaga acttcaggct ggtaaatcta 37020 ttaatgttaa acatacatct gtttcagcta agcaactaag aacacgtata ctctcatctt 37080 ttgccaacac agagggtgga tatttgttca ttggagttga taataataca cacaaagtat 37140 ttggattcac ggtgggttac gactacctca gactgataga gaatgatata gaaaagcata 37200 tcaaaagact ttgtgttgtg tatttctgtg agaagaaaga ggac atcaag tacacgtgtc 37260 gattcatcaa ggtatataaa cctggggatg aggctacctc gacatacgtg tgcgctatca 37320 aagtggaaag atgctgttgt gctgtgtttg cagattggcc agaatcatgg tatcaagaag 37380 tattctccag atgaataggt gtcacatata aaattttaat taatgtaact atagagaaca 37440 aataataggt tgtaatatca tatagacaat aactaacaat taattagtaa ctgttatctc 37500 tttttaacta actaactata cctattaata catcgtaatt atagttctta acatctatta 37560 atcattgatt cgcttcttta attttttata aaccaacatt gttaattgaa aagggataac 37620 atgttacaga atataaatta tatatggatt ttttttaaaa aggaaatact tgactggagt 37680 gtatatttat ctcttcatta tatagcacgc gtgttttcca atttttccac atcccatata 37740 atacaggatt ataatctcgt tcgaacatac gagaaagtgg ataaaacaat agttgatttt 37800 ttatctaggt tgccaaattt attccatatt ttagaatatg gggaaaatat tctacatatt 37860 tattctatgg atgatgctaa tacgaatatt ataatttttt ttctagatag agtattaaat 37920 attaataaga acgggtcatt tatacacaat ctcaggttat catcatccat taatataaaa 37980 gaatatgtat atcaattagt taataatgat catccagata ataggataag actaatgctt 38040 gaaaatggac gtagaacaag acattttttg tcctata tat cagatacagt taatatctat 38100 atatgtattt tatatagatg ccgaagacag ttacggttgt acattattac atagatgtat 38160 atatcactat aagaaatcag aatcagaatc agaatcatac aatgaattaa ttaagatatt 38220 gttaaataat ggatcagatg tagataaaaa agatacgtac ggaaacacac cttttatcct 38280 attatgtaaa cacgatatca acaacgtgga attgtttgag atatgtttag agaatgctaa 38340 tatagactct gtagacttta atagatatac acctcttcat tatgtctcat gtcgtaataa 38400 atatgatttt gtaaagttat taatttctaa aggagcaaat gttaatgcgc gtaataaatt 38460 cggaactact ccattttatt gtggaattat acacggtatc tcgcttataa aactatattt 38520 ggaatcagac acagagttag aaatagataa tgaacatata gttcgtcatt taataatttt 38580 tgatgctgtt gaatctttag attatctatt atccagagga gttattgata ttaactatcg 38640 tactatttac gacgctgtca gttataatgc gtataatacg ttggtctatc tattaaacag 38700 aaatggtgat tttgagacga ttactactag tggatgtaca tgtatttcgg aagcagtcgc 38760 aaacaacaac aaaataataa tggaagtact attgtctaaa cgaccatctt tgaaaattat 38820 gatacagtct atgatagcaa ttactaaaca taaacagcat aatgcagatt tattgaaaat 38880 gtgtataaaa tatactgcgt gtatgaccga ttatgatact cttatagatg tacaatcact 38940 acagcaatat aaatggtata ttttaagatg tttcgatgaa atagatatca tgaagagatg 39000 ttatataaaa aataaaactg tattccaatt agttttttgt atcaaagaca ttaatacttt 39060 aatgagatac ggtaaacatc cttctttcgt gaagtgcact agtctcgacg tatacggaag 39120 tcgtgtacgt aatatcatag catctattag atatcgtcag agattaatta gtctattatc 39180 caagaagctg gatcctggag ataaatggtc gtgttttcct aacgaaataa aatataacga 39240 taacgaactg tccacatatc taaaaatctt ataaacacta ttaaaatata aaatcacact 39300 acatcattgt ttccttttag tgctcgacag tgtatactat ttttaacgct cataaataaa 39360 aatgaaaacg atttccgttg ttacgttgtt atgcgtacta cctgctgttg tttattcaac 39420 atgtactgta cccactatga ataacgctaa attaacgtct accgaaacat cgtttaataa 39480 taaccagaaa gttacgttta catgtgatca gggatatcat tcttcggatc caaatgctgt 39540 ctgcgaaaca gataaatgga aatacgaaaa tccatgcaaa aaaatgtgca cagtttctga 39600 ttacatctct gaactatata ataaaccgct atacgaagtg aattccacca tgacactaag 39660 ttgcaacggc gaaacaaaat attttcgttg cgaagaaaaa aatggaaata cttcttggaa 39720 tgatactgtt acgtgtccta at gcggaatg tcaacctctt caattagaac acggatcgtg 39780 tcaaccagtt aaagaaaaat actcatttgg ggaatatata actatcaact gtgatgttgg 39840 atatgaggtt attggtgctt cgtacataag ttgtacagct aattcttgga atgttattcc 39900 atcatgtcaa caaaaatgtg atataccgtc tctatctaat ggattaattt ccggatctac 39960 attttctatc ggtggcgtta tacatcttag ttgtaaaagt ggttttatac taacgggatc 40020 tccatcatcc acatgtatcg acggtaaatg gaatcccata ctcccaacat gtgtacgatc 40080 taacgaaaaa tttgatccag tggatgatgg tcccgacgat gagacagatt tgagcaaact 40140 ctcgaaagac gttgtacaat atgaacaaga aatagaatcg ttagaagcaa cttatcatat 40200 aatcatagtg gcgttaacaa ttatgggcgt catattttta atctccgtta tagtattagt 40260 ttgttcctgt gacaaaaata atgaccaata taagttccat aaattgctac cgtgaatata 40320 aatccgttaa aataatgaat aattaataat taataattta ataacaaaca agtatcaaaa 40380 gattaaagac ttatagctag aatcaattga gatgtcttct tcagtggatg ttgatatcta 40440 cgatgccgtt agagcatttt tactcaggca ctattataac aagagattta ttgtgtatgg 40500 aagaagtaac gccatattac ataatatata caggctattt acaagatgcg ccgttatacc 40560 gttcgatgat atagt acgta ctatgccaaa tgaatcacgt gttaaacaat gggtgatgga 40620 tacacttaat ggtataatga tgaatgaacg cgatgtttct gtaagcgttg gcaccggaat 40680 actattcatg gaaatgtttt tcgattacaa taaaaatagt atcaacaatc aactaatgta 40740 tgatataatt aatagcgtat ctataattct agctaatgag agatatagaa gcgcttttaa 40800 cgacgatggt atatacatcc gtagaaatat gattaacaag ttgtacggat acgcatctct 40860 aactactatt ggcacgatcg ctggaggtgt ttgttattat ctgttgatgc atctagttag 40920 tttgtataaa taattatttc aatatactag ttaaaatttt aagattttaa atgtataaaa 40980 aactaataac gtttttattt gtaataggtg cattagcatc ctattcgaat aatgagtaca 41040 ctccgtttaa taaactgagt gtaaaactct atatagatgg agtagataat atagaaaatt 41100 catatactga tgataataat gaattggtgt taaattttaa agagtacaca atttctatta 41160 ttacagagtc atgcgacgtc ggatttgatt ccatagatat agatgttata aacgactata 41220 aaattattga tatgtctact attcaacgca gaggtcacac gtgtagaata tctaccaaat 41280 tatcatgcca ttatgataag tacccttata ttcacaaata tgatggtgat gagcgacaat 41340 attctattac tgcagaggga aaatgctata aaggaataaa atatgaaata agtatgatca 41400 acgatgatac tctattgaga aaacatactc ttaaaattgg atctacttat atatttgatc 41460 gtcatggaca tagtaataca tattattcaa aatatgattt ttaaaaattt aaaatatatt 41520 atcacttcag tgacagtagt caaataacaa acaacaccat gagatatatt ataattctcg 41580 cagttttgtt cattaatagt atacacgcta aaataactag ttataagttt gaatccgtc a 41640 attttgattc caaaattgaa tggactgggg atggtctata caatatatcc cttaaaaatt 41700 atggcatcaa gacgtggcaa acaatgtata caaatgtacc agaaggaaca tacgacatat 41760 ccgcatttcc aaagaatgat ttcgtatctt tctgggttaa atttgaacaa ggcgattata 41820 aagtggaaga gtattgtacg ggaccaccga ctgtaacatt aactgaatac gacgaccatc 41880 cgtatgctac tagaggtagc aaaaagattc ctatttacaa acgcggtgac atgtgtgata 41940 tctacttgtt gtatacggct aacttcacat tcggagattc taaagaacca gtaccatatg 42000 atatcgatga ctacgattgc acgtctacag gttgcagcat agactttgtc acaacagaaa 42060 aagtgtgcgt gacagcacag ggagccacag aagggtttct cgaaaaaatt actccatgga 42120 gttcgaaagt atgtctgaca cctaaaaaga gtgtatatac atgcgcaatt agatccaaag 42180 aagatgttcc caatttcaag gacaaaatgg ccagagttat caagagaaaa tttaactaaa 42240 tttctcggta gcacatcaaa tgatgttacc acttttctta gcatgcttaa cttgactaaa 42300 tattcataac taatttttat taatgataca aaaacgaaat aaaactgcat attatacact 42360 ggttaacgcc cttataggct ctaaccattt tcaagatgag gtccctgatt atagtccttc 42420 tgttcccctc tatcatctac tccatgtcta ttagacgatg tgagaagact g aagaggaaa 42480 catggggatt gaaaataggg ttgtgtataa ttgccaaaga tttctatccc gaaagaactg 42540 attgcagtgt tcatctccca actgcaagtg aaggcaatgg attcagggat atacgaaaca 42600 ccgataaatt ataaaaaaag caatgtgtcc gctgtttccg ttaataatac tattttcgta 42660 actggcggat tattcataaa taactctaat agcacgatcg tggttaacaa tatggaaaaa 42720 cttgacattt ataaagacaa acaatggtcg attatagaaa tgcctatggc tagggtatat 42780 cacggcatcg actcgacatt tggaatgtta tattttgccg gaggtctatc cgttaccgaa 42840 caatatggta atttagagaa aaacaacgag atatcttgtt acaatcctag aacgaataag 42900 tggtttgata tttcatatac tatttataag atatccatat catcattgtg taaactaaat 42960 aacgtcttct atgtatttag taaggacatt ggatatgtgg aaaagtatga tggtctcccc 43020 gctataaagg cattatcaac ttctccttat tgattgaaaa tgaaaatata aatagttttt 43080 atgtatagca gtattaccct atagttttat tgcttactac taacatggat acagatacag 43140 atgttacaaa tgtagaagat atcatgaatg aaatagatag agagaaagaa gaaatactaa 43200 aaaatgtaga aattgaaaat aataaaaaca ttaacaagaa tcatcccaat gaatatatta 43260 gagaagcact cgttattaat acaagtagta atagtgattc catt gataaa gaagttatag 43320 aatgtatcag tcacgatgta ggaatataga tcatatctac taatttttat aatcaataca 43380 aaacataaaa aacaactcgt tattacatag caggcatgga atccttcaag tattgttttg 43440 ataacgatgg caagaaatgg attatcggaa atactttata ttctggtaat tcaatactct 43500 ataaggtcag aaaaaatttc actagttcgt tctacaatta cgtaatgaag atagatcaca 43560 aatcacacaa gccattgttg tctgaaatac gattctatat atctgtattg gatcctttga 43620 ctatcgacaa ctggacacgg gaacgtggta taaagtattt ggctattcca gatctgtatg 43680 gaattggaga aaccgatgat tatatgttct tcgttataaa gaatttggga agagtattcg 43740 ccccaaagga tactgaatca gtcttcgaag catgcgtcac tatgataaac acgttagagt 43800 ttatacactc tcgaggattt acccatggaa aaatagaacc gaggaatata ctgattagaa 43860 ataaacgtct ttcactaatt gactattcta gaactaacaa actatacaag agtggaaact 43920 cacatataga ttacaacgag gacatgataa cttcaggaaa tatcaattat atgtgtgtag 43980 acaatcatct tggagcaaca gtttcaaaac gaggagattt agaaatgttg ggatattgca 44040 tgatagaatg gttcggtggc aaacttccat ggaaaaacga aagtagtata aaagtaataa 44100 aacaaaaaaa agaatataaa aaatttatag ctacttt ctt tgaggactgt tttcctgaag 44160 gaaatgaacc tctggaatta gttagatata tagaattagt atacacgtta gattattctc 44220 aaactcctaa ttatgacaga ctacgtagac tgtttataca agattgaaat attctttttt 44280 tatagagtgt ggtagtgtta cggatatcta atattaatat tagactatct ctatcgcgct 44340 acacgaccaa tatcgattac tatggatatc ttctatgaaa ggagagaatg tattcatttc 44400 tccagcgtca atctcgtcag tattgacaat actgtattat ggagctaatg gatccactgc 44460 tgaacagcta tcaaaatatg tagaaaagga ggagaacacg gataaggtta gcgctcagaa 44520 tatctcattc aaatccatga ataaagtata tgggcgatat tctgccgtgt ttaaagattc 44580 ctttttgaga aaaattggcg ataagtttca aactgttgac ttcactgatt gtcgcactat 44640 agatgcaatc aacaagtgtg tagatatctt tactgagggg aaaatcaatc cactattgga 44700 tgaacaattg tctcctagca attagtgccg tatactttaa agcaaaatgg ttgacgccat 44760 tcgaaaagga atttaccagt gattatccct tttacgtatc accaacggaa atggtagacg 44820 taagtatgat gtctatgtac ggcgagctat ttaatcacgc atctgtaaaa gaatcattcg 44880 gtaacttttc aatcatagaa ctgccatatg ttggagatac tagtatgatg gtcattcttc 44940 cagacaagat tgatggatta gaatccatag aacaaaatct aacagataca aattttaaga 45000 aatggtgtaa ctctctggaa gctacgttta tcgatgttca cattcccaag tttaaggtaa 45060 caggctcgta taatctggtg gatactctag taaagtcagg actgacagag gtgttcggtt 45120 caactggaga ttatagcaat atgtgtaatt tagatgtgag tgtcgacgct atgatccaca 45180 aaacgtatat agatgtcaat gaagagtata cagaagcagc tgcagcaact tgtgcactgg 45240 tgtcagactg tgcatcaaca attacaaatg agttctgtgt agatcatccg ttcatctatg 45300 tgattaggca tgttgatgga aaaatttttt tcgttggtag atattgctct ccgacaacta 45360 attgttaacc atttttttta aaaaaataga aaaaacatgt ggtattagtg caggtcgtta 45420 ttcttccaat tgcaattggt aagatgacgg ccaactttag tacccacgtc ttttcaccac 45480 agcactgtgg atgtgacaga ctgaccagta ttgatgacgt caaacaatgt ttgactgaat 45540 atatttattg gtcgtcctat gcataccgca acaggcaatg cgctggacaa ttgtattcca 45600 cactcctctc ttttagagat gatgcggaat tagtgttcat cgacattcgc gagctggtaa 45660 aaaatatgcc gtgggatgat gtcaaagatt gtgtagaaat catccgttgt tatataccgg 45720 atgagcaaaa aaccatcatc ggactttgtg catatgctgc tacttactgg ggaggtgaag 45780 accatcccac tagtaacagt ct gaacgcat tgtttgtgat gcttgagatg ctaaattacg 45840 tggattataa catcatattc cggcgtatga attgatgagt tgtacatctt gacattttct 45900 tctttcttct cttctccctt tcccagaaac aaactttttt tacccactat aaaataaaat 45960 gagtatacta cctgttatat ttctttctat atttttttat tcttcattcg ttcagacttt 46020 taacgcgcct gaatgtatcg acaaagggca atattttgca tcattcatgg agttagaaaa 46080 cgagccagta atcttaccat gtcctcaaat aaatacgcta tcatccggat ataatatatt 46140 agatatttta tgggaaaaac gaggagcgga taatgataga attataccga tagataatgg 46200 tagcaatatg ctaattctga acccgacaca atcagactct ggtatttata tatgcattac 46260 cacgaacgaa acctactgtg acatgatgtc gttaaatttg acaatcgtgt ctgtctcaga 46320 atcaaatata gatcttatct cgtatccaca aatagtaaat gagagatcta ctggcgaaat 46380 ggtatgtccc aatattaatg catttattgc tagtaacgta aacgcagata ttatatggag 46440 cgggcatcga cgccttagaa ataagagact taaacaacgg acacctggaa ttattaccat 46500 agaagatgtt agaaaaaatg atgctggtta ttatacatgt gttttagaat atatatacgg 46560 tggcaaaaca tataacgtaa ccagaattgt aaaattagag gtacgggata aaataatacc 46620 ttctactatg caatt accag aaggtgttgt aacttcaata ggtagtaatt tgactattgc 46680 gtgtagagta tcgttgagac ctcccacaac ggatgcagac gtcttttgga taagtaatgg 46740 tatgtattac gaagaagatg atggggacgg agacggtaga ataagtgtag caaataaaat 46800 ctatatgacc gataagagac gtgttattac atcccggtta aacattaatc ctgtcaagga 46860 agaagatgct acaacgttta cgtgtatggc gtttactatt cctagcatca gcaaaacagt 46920 tactgttagt ataacgtgaa tgtatgttgt tacatttcca tgtcaattga gtttataaga 46980 atttttatac attatcttcc aacaaacaat tgacgaacgt attgctatga ttaactccca 47040 cgatactatg catattatta atcattaact tgcagactat acctagtgct attttgacat 47100 actcatgttc ttgtgtaatt gcggtatcta tattattaaa gtacgtaaat ctagctatag 47160 ttttattatt taattttaga taatataccg tctccttatt tttaaaaatt gccacatcct 47220 ttattaaatc atgaatggga atttctatgt catcgttaat atattgtgaa caacaagagc 47280 agatatctat aggaaagggt ggaatgcgat acattgatct atgtagtttt aaaacacacg 47340 cgaactttga agaatttata taaatcattc catcgataca tccttctatg ttgacatgta 47400 tatatccagg aattctttta ttaatgtcag gaaatgtata aactaaaaca ttgcccgaaa 47460 gcggtgcc tc tatctgcgtt atatccgttc ttaacttaca aaatgtaacc aatacctttg 47520 catgacttgt tttgttcggc aacgttagtt taaacttgac gaatggatta attacaatag 47580 catgatccgc gcatctatta agttttttta ctttaacgcc cttgtatgtt tttacagaga 47640 ctttatctaa atttctagtg cttgtatgtg ttataaatat aacgggatat agaactgaat 47700 cacctacctt agatacccaa ttacatttta tcagatccag ataataaaca aattttgtcg 47760 ccctaactaa ttctatattg ttatatattt tacaattggt tatgatatca tgtaataact 47820 tggagtctaa cgcgcatcgt cgtacgttta tacaattgtg atttagtgta gtatatctac 47880 acatgtattt ttccgcacta tagtattctg gactagtgat aaaactatcg ttatatctgt 47940 cttcaatgaa ctcatcgaga tattgctctc tgtcatattc atacacctgc ataaactttc 48000 tagacatctt acaatccgtg ttattttagg atcatattta catatttacg ggtatatcaa 48060 agatgttaga ttagttaatg ggaatcgtct ataataatga atattaaaca attatatgag 48120 gacttttacc acaaagcatc ataaaaatga gtcgtcgtct gatttatgtt ttaaatatca 48180 accgcgaatc aactcataaa atacaagaga atgaaatata tacatatttt agtcattgca 48240 atatagacca tacttctaca gaacttgatt ttgtagttaa aaactatgat ctaaacagac 48300 gacaacctgt aactgggtat actgcactac actgctattt gtataataat tactttacaa 48360 acgatgtact gaagatatta ttaaatcatg gagtggatgt aacgatgaaa accagtagcg 48420 gacgtatgcc tgtttatata ttgcttacta gatgttgtaa tatttcacat gatgtagtga 48480 tagatatgat agacaaagat aaaaaccact tatcgcatag agactattcc aacctactac 48540 tagagtatat aaaatctcgt tacatgttat tgaaggaaga ggatatcgat gagaacatag 48600 tatccacttt attagataag ggaatcgatc ctaactttaa acaagacgga tatacagcgt 48660 tacattatta ttatttgtgt ctcgcacacg tttataaacc aggtgagtgt agaaaaccga 48720 taacgataaa aaaggccaag cgaattattt ctttgtttat acaacatgga gctaatctaa 48780 acgcgttaga taattgtggt aatacaccat tccatttgta tcttagtatt gaaatgtgta 48840 ataatattca tatgactaaa atgctgttga cttttaatcc gaatttcaaa atatgtaata 48900 atcatggatt aacgcctata ctatgttata taacttccga ctacatacaa cacgatattc 48960 ttgttatgtt aatacatcac tatgaaacaa atgttggaga aatgccgata gatgagcgtc 49020 gtataatcgt attcgagttt atcaaaacat attctacacg tccggcagat tcgataactt 49080 atttgatgaa taggtttaaa aatatagata tttatacccg ctatgaagga aagacatta t 49140 tacacgtagc atgtgaatat aataatacac acgtaataga ttatcttata cgtatcaacg 49200 gagatataaa tgcgttaacc gacaataaca aacacgctac acaactcatt atagataaca 49260 aagaaaattc cccatatacc attaattgtt tactgtatat acttagatat attgtagata 49320 agaatgtgat aagatcgttg gtggatcaac ttccatctct acctatcttc gatataaaat 49380 catttgagaa attcatatcc tactgtatac ttttagatga cacattttac aatagacacg 49440 ttaggaatcg caattctaaa acgtatcgat acgcattttc aaaatacatg tcgtttgata 49500 aatacgatgg tataataact aaatgtcata aagaaacaat attgctcaaa ctatccactg 49560 ttctagacac tacactatat gcagttttaa gatgccataa ttcgaaaaag ttaagaagat 49620 acctcaacga gttaaaaaaa tataataacg ataagtcctt taaaatatat tctaatatta 49680 tgaatgagag ataccttaat gtatattata aagatatgta cgtgtcaaag gtatatgata 49740 aactatttcc tgttttcaca gataaaaatt gtctactaac attactacct tcagaaatta 49800 tatacgaaat attatacatg ctgacaatta acgatcttta taatatatcg tatccaccta 49860 ccaaagtata gttgtatttt tctcatgcga tgtgtgtaaa aaaactgata ttatataaat 49920 attttagtgc cgtataatga agatgacgat gaaaatgatg gtacatatat a tttcgtatc 49980 attattgtta ttgctattcc acagttacgc catagacatc gaaaatgaaa tcacagaatt 50040 cttcaataaa atgagagata ctctaccagc taaagactct aaatggttga atccagcatg 50100 tatgttcgga ggcacaatga atgatatagc cgctctagga gagccattca gcgcaaagtg 50160 tcctcctatt gaagacagtc ttttatcgca cagatataaa gactatgtgg ttaaatggga 50220 gaggctagaa aaaaatagac ggcgacaggt ttctaataaa cgtgttaaac atggtgattt 50280 atggatagcc aactatacat ctaaattcag taaccgtagg tatttgtgta ccgtaactac 50340 aaagaatggt gactgtgttc agggtatagt tagatctcat attaaaaaac ctccttcatg 50400 cattccaaaa acatatgaac taggtactca tgataagtat ggcatagact tatactgtgg 50460 aattctttac gcaaaacatt ataataatat aacttggtat aaagataata aggaaattaa 50520 tatcgacgat attaagtatt cacaaacggg aaagaaatta attattcata atccagagtt 50580 agaagatagt ggaagataca actgttacgt tcattacgac gacgttagaa tcaagatgta 50640 aaatacttac ggttataccg tcgcaagacc acaggtttaa actaatacta gatccaaaaa 50700 tcaacgtaac gataggagaa cctgccaata taacatgcac tgctgtgtca acgtcattat 50760 tgattgacga tgtactgatt gaatgggaaa atccatccgg atgg cttata ggattcgatt 50820 ttgatgtata ctctgtttta actagtagag gcggtatcac cgaggcgacc ttgtactttg 50880 aaaatgttac tgaagaatat ataggtaata catataaatg tcgtggacac aactattatt 50940 ttgaaaaaac ccttacaact acagtagtat tggagtaaat acacaatgca tttttatata 51000 cattactgaa taattattat tattatttat atcgtatttg tgctataacg cgactatcta 51060 ggtatttgta tctcaccgat agagaacata taaatgtaga ctctattaaa cagttgtgta 51120 aaatatcaga tcctaataga tgtggatgta cggctttaga aatgagttca ttaaaatatg 51180 tgatatcaac ggaacatatt tatataatta tactattgct gttagtataa ttattgattc 51240 cacggaagaa ctaccaacag ttactccaat tacaacaaca tataattata ctatcgatga 51300 tagcactact gaagaactac aagtgactcc tcatatggat ctccatcgat gatacatgta 51360 ttaaaatact ttccgaataa gtcttttaaa tattgtatta attatgaaaa actatgctat 51420 gcgagtatga tacgatacta gattttatct ctagcgagag atgtcgttag aatcatttat 51480 caacgaatat cgataacatg tgtcatttat acgttaaagt ctgtccgtct tctctattgt 51540 ttagactgtt tgtagaatgc tgtgatataa acaaactagt agacacaaat atttaactca 51600 tgatgaagtt gagaatgata tgctttagct aatataa aaa tatattaatc cactatatat 51660 tctagacttg atttaaaacc gataaactac tactacgtac tgtataagtt aggagcagac 51720 cctaattatg tagatgatag aggtaatact tctgcatcta tatgtccact tatgagaaaa 51780 cgtcatttaa taagatgcat cgtgaaaaga aatttattaa agagttggta aaatatgaaa 51840 ccgaaagtaa ataatatagg aaatacacct ctacataact acgtatctca atatgatatc 51900 actctcattc ctcatccaca acccattaaa aaatggaaat taaagccctc tattagcata 51960 aacggctaca ggtctacctt tacaatggcc tttccttgtg cccagttcag accctgtcat 52020 tgccacgcta ctaaggactc cctgaatacc gtggccgacg tcagacattg tctgactgaa 52080 tacatcctgt gggtttctca tagatggacc catagagaaa gcgcagggtc tctctacagg 52140 cttctcatct ctttcagaac tgatgcaacg gagctctttg gtggtgagtt gaaggattca 52200 cttccgtgga gatcattaaa tgactccatg aaaaccgccg aagaacttcg tgcaatcatt 52260 ggactttgta ctcaatcagc tatcgtctct ggaagagtct tcaacgataa gtatatcgac 52320 atactactta tgctgcgaaa gattctgaac gagaacgact atctcaccct cttggatcat 52380 atccgcactg ctaaatacta aatctccttc atgctctctc actacacttt ttatcatctt 52440 atgaggaata attagcacca gaatagctat ggattgcaca tgtattctat gtcgtctact 52500 ggatgaagat gtgacgtaca aaaaaataaa actagaaatt gaaacgtgtc acaacttatc 52560 aaaacatata gatagacgag gaaacaatgc gctacattgt tacgtctcca ataaatgcga 52620 tacagacatt aagattgttc gactgttact ctctcgcgga gtcgagagac tttgtagaaa 52680 caacgaagga ttaactccgc taggagcata cagtaagcat agatacgtaa aatctcagat 52740 tgtgcatcta ctgatatcca gctattcgaa ttcctctaac gaactcaagt cgaatataaa 52800 tgatttcgac ttacgtctgc taaaatacct aattgtggat aaacggatac gtccgtccaa 52860 gaatacgaat tatgcaatca atggtctcgg attggtggat atatacgtaa cgacgcctaa 52920 tccgagacca gaagtattgc tatggcttct taaatcagaa tgttacagca ccggttacgt 52980 atttcgtacc tgtatgtaca acagtgatat gtgtaagaac tctcttcatt actatatatc 53040 gtctcataga gaatctctat ccaaggatgt aattaaatgt ttgatcgata acaatgtttc 53100 catccaatac tactggtctt gctcaaccat agatatagag attattaata aaggatgtgg 53160 acacgtgtag agtatacgac gtcagcccta tattagaggc gtattatcta aacaagcgat 53220 ttagagtaac cccatataat gtagacatgg aaatcgttaa tcttcttatt gagagacgtc 53280 atactcttgt cgacgtaatg cg tagtatta cttcgtacga ttccagagaa tataaccact 53340 acatcatcga taacattcta aagagattta gacaacagga tgaatccatc gtacaagcca 53400 tactgataaa ctacttacat tacggcgata tggtaagtat acctatcatt caatgcatgt 53460 tggataagac gacggacaac aactttgtta ataataatct cgtcgatgta aacgtcgtaa 53520 ggtttatcgt ggaaaatatg gacacgcggc tgtaaatcac atatctaaca atggccgtct 53580 atgtatgtac ggtctgatat tatcgagatt taataattgc gggtatcact gttatgaaga 53640 tgtatttgat atactaagca agtacatgga tgatatagat atgatcgata actctactat 53700 attacgcggt cgatgtcaat aatatacaat ttgcaaagcg gttattggaa tatggagcga 53760 gtgtcacgct cgataatcaa tacggccatc cagaaaagca gttaccaaag agaagctagt 53820 tgatttatta ctgagttacc atcccactct agagactatg attgacgcat ttaatagaga 53880 tatacgctat ctatatcctg aaccattatt cgcctgtatc agatacgcct taatcctaga 53940 tgatgatttt ccttctaaag taagtatgat atcgccggtc gtcataagga actaaagcgc 54000 tatagagcag acattaatag aatgaagaat gcctacatat caggcgtctc catgtttgat 54060 atattattta aacgaagcaa acgccacaga ttgagatacg caaagaacaa tgagaggatc 54120 gactccatta aataa tttat catggagtga taatgtcctg tttccatggc atattacaaa 54180 atcgattccg tccaagatga taaaaacatt taccggcatc ataaacacgg agtttatttt 54240 atatgtctcg cataaacatt actaaaaaaa tatattgttc ggttttcttt cacatcttta 54300 attatgaaaa agtaaatcat tatgagatgg acgcatcgtt cgcgacagta tgtggtacat 54360 acctaacgta tttatggacg acggtaagaa tgaaggtcac gtttctgtca acaatgtcga 54420 cgcgatcgtg taacacgact cacaatagaa tctgtgaatg ctctcccgat catggatgca 54480 aggcatgtgt ttcccaaaca aaatgtggaa taggatacgg agtatccgga gacgtcatct 54540 gttctccgtg tggtctcgga acatattctc acaccgtctc ttccgcagat aaatgcgaac 54600 ccgtacccag aaataccttt aactatatcg atgtggaaat taacctgtat ccagttaacg 54660 acacatcgtg tactcggacg accactaccg gtctcagcga atccatctca acgtcggaac 54720 taactattac tatgaatcat aaagactgcg atcccgtctt cttaataagg tagcgacttc 54780 aggtttcttt acaggagaaa ggtgtgcact ctgaatttcg agattaaatg caataacaaa 54840 gattcttcct ccaaacagtt aacgaaagca aagaatgata ctatcatgcc gcattcggag 54900 acagtaactc tagcgtcgac atctatatac tatatagtaa taccaatact caagactacg 54960 aaactgatac aatctcttat catgtgggta atgtagccat atgcccggta gttgcgatat 55020 acataaactg atcactaatt ccaaacccac ccgcttttta tagtaagttt ttcacccata 55080 aatacaataa ttaatttctc gtaaaagtag aaaatatatt ctaatttatt gcacggtaag 55140 gaagtagaat cataaagaac agtactcaat caatagcaat catgaaacaa tatatcgta c 55200 tggcatgcat gtgcctgcca gtcttcagca atcatcctca tcgtgtacgg aagaagaaaa 55260 caaacatcat atgggaatcg atgttattat caaagtcaca aagcaagacc aaacaccgac 55320 cgatgataag atttgccaat ccgtaacgga aattacagag tccgagtcag atccagatcc 55380 cgaggtggaa tcagtcgagg atgtagatcc tcctaccact tattactcca tcatcggtgg 55440 aggtctgaga atgaactttg gattcaccaa atgtcctcag attaaatcca tctcagaatc 55500 cgctgatgga aagactgtga ggtgtctatc gacatcagat gtagcgaaga agagaaagac 55560 agcgacatca agacccatcc agtactcggg tctaacatct ctcataagaa agtgagttac 55620 gaagatatca tcggttcaac gatcgtcgat acaaaatgtg tcaagaatct agagtttagc 55680 gttcgtatcg gagacatgtg caaggaatca tctgaacttg aggtcaagta tgtcgacgga 55740 tcggcatctg aaggtgcaac cgatgatact tcactcatcg attcaacaaa actcaaagcg 55800 tgtgtctgaa tcgataactc tattcatctg aaattggatg agtagggtta atcgaacgat 55860 tcaggcacac cacgaattaa aaaagtgtac cggacactat attccggttt gcaaaacaaa 55920 aagttacctc tcgcgacttc ttctttttct gtctcaatag tgtgatacga ttatgacact 55980 attcctattt cctttcaggg tatcacaaaa atattaaacc tctttctgat g gtctcatac 56040 aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaatatt tttattctct 56100 ttctctcttt gatggtctca taaaatattt ttattctctt tctctctttg atggtctcat 56160 aaaaaatatt tttattctct ttctctcttt gatggtctca taaaatattt ttattctctt 56220 tctctctttg atggtctcat aaaaaatatt tttattctct ttctctcttt gatggtctca 56280 taaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc tctttctctc 56340 ttcaatggag tcataaaata tttttattct ctttctctct tcgatggtct cacaaaaata 56400 ttaaacctct ttctgatggt gtcactaaaa tatttttatt ctctttctct cttcaatgga 56460 gtcataaaat atttttattc tctttctctc tttgatggtc tcacaaaaat atttttattc 56520 tctttctctc tttgatggtc tcacaaaaat atttttattc tctttctctc tttgatggtc 56580 tcacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 56640 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 56700 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 56760 tctctttctc tctttgatgg tctcataaaa aatattaaac ctctttctga tggtgtcact 56820 aaaatatttt tattctcatt ctctcttcaa tggagtcata aaat attttt attctctttc 56880 tctcttcgat ggtctcacaa aaatattaaa cctctttctg atggtgtcac taaaatattt 56940 ttattctcat tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga 57000 tggtctcaca aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca 57060 ttctctcttc aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat 57120 aaaaaaagtt ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa 57180 tattaaacct ctttctgatg gtgtcactaa aatattttta ttctctttct ctcttcaatg 57240 gagtcataaa atatttttat tctctttctc tcttcgatgg tctcacaaaa atattaaacc 57300 tctttctgat ggtgtcacta aaatattttt attctcattc tctcttcaat ggagtcataa 57360 aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 57420 tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 57480 ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 57540 ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 57600 ttgatggtct cataaaaaat attaaacctc tttctgatgg tgtcactaaa atatttttat 57660 tctcattctc tcttcaatgg agtcataaaa tattttt att ctctttctct cttcgatggt 57720 ctcacaaaaa tattaaacct ctttctgatg gtgtcactaa aatattttta ttctcattct 57780 ctcttcaatg gagtcataaa atatttttat tctctttctc tctttgatgg tctcataaaa 57840 aaagttttac aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 57900 ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 57960 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 58020 ttttattctc tttctctctt tgatggtctc acaaaaatat taaacctctt tctgatggag 58080 tcgtaaaaaa gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt 58140 ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt 58200 aaacctcttt ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca 58260 ctaaaatatt ttttattctc tttctgatgc atcaactatt tcttaaacaa taacgtccaa 58320 caacatatac tcgtcgagct tatcaacatc ccctatgccc atctaggtta ccagacaatt 58380 gtatatcata aaataatgtt tataattttt acaaaaatat ttttattctc tttctctctt 58440 tgatggtctc ataaaaaaag ttttacaaaa atatttttat tctctttctc tctttgatgg 58500 tctcataaaa aatattaaac ctctttctga tggtgtcact aaaatatttt tattctcatt 58560 ctctcttcaa tggagtcata aaatattttt attctctttc tctcttcgat ggtctcacaa 58620 aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctcat tctctcttca 58680 atggagtcat aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt 58740 tacaaaaata tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa 58800 aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 58860 tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 58920 ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 58980 ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 59040 ttgatggtct cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg 59100 gtctcataaa aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctctt 59160 tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga tggtctcaca 59220 aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca ttctctcttc 59280 aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 59340 ttacaaaaat atttttattc tc tttctctc tttgatggtc tcataaaaaa agttttacaa 59400 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 59460 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 59520 tctctttctc tctttgatgg tctcataaaa aaagttttac aaaaatattt ttattctctt 59580 tctctctttg atggtctcat aaaaaatatt aaacctcttt ctgatggtgt cactaaaata 59640 tttttattct ctttctctct tcaatggagt cataaaatat ttttattctc tttctctctt 59700 cgatggtctc acaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc 59760 tctttctctc ttcaatggag tcataaaata tttttattct ctttctctct ttgatggtct 59820 cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg gtctcataaa 59880 aaaagtttta caaaaatatt tttattctct ttctctcttt gatggtctca taaaaaaagt 59940 tttacaaaaa tatttttatt ctctttctct ctttgatggt ctcataaaaa aagttttaca 60000 aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt tacaaaaata 60060 tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa aatattttta 60120 ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt tttattctct 60180 ttctctcttt gatgg tctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60240 atttttattc tcattttctc tttctctctt caatggagtc ataaaatatt tttattctct 60300 ttctctcttt gatggtctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60360 atttttattc tcattctctc ttcaatggag tcataaaaaa gttttatctc tttctctctt 60420 cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc 60480 tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatgcat caactatttc 60540 ttaaacaata acgtccaaca acatatactc atcccctatg cccatctagg ttaccagaca 60600 attgtatatc ataaaataat gtttataatt tacacgttaa aatcatataa taaaacgtag 60660 atcgtataat attttttggt atataaatga tctagtaaaa tccatgtagg ggatactgct 60720 cacatttttt ctttggtaca aaatttcaca caagttttta tacagacaaa ttcttgtcca 60780 tatattttaa aacattgact tttgtactaa gaaaaatatc tagactaact atctctttct 60840 ctttctctct tcgatggtct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 60900 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 60960 ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 61020 agttttat ct ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag 61080 tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat taaacctctt 61140 tctgatggtg tcactaaaat atttttattc tctttctctc ttcgatggtc tcacaaaaat 61200 attaaacctc tttctgatgg agtcgtaaaa aagttttatc tctttctcct tcgatggtct 61260 cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 61320 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 61380 ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa 61440 gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt ctgatggagt 61500 cgtaaaaaag ttttatctct ttctccttcg atggtctcac aaaaatatta aacctctttc 61560 tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac aaaaatatta 61620 aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac 61680 aaaaatatta aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctccttcga 61740 tggtctcaca aaaatattaa acctctttct gatggtctct ataaagcgat tgatttttct 61800 taccctctag agtttcctac ggtcgttggt cacacatttt tttctagaca ctaaataaat 61860 agtaagatta aattaattat aaaattatgt atataatatt aattataaaa ttatgtatat 61920 gatttactaa ctttagttag ataaattaat aatacataaa ttttagtata ttaatattat 61980 aaattataataa tacataaatt ttagtatat aatattatat tattagatgt gg cctattaga <210> 15
<211> 62068
<212> DNA
<213> Artificial Sequence
<220>
<223> sMVA F3
<400> 15 ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60 attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120 aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180 gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccgggt 240 attaataata tctatatttc cagcgttaag tgtaacatta aacagtttta attcacgtga 300 cgtggtatca attaaataat taatgcccaa tttggatata gcagcctgaa gctcatcttg 360 tttagttacg gatcctaatg agttattaag caatatatcg aacggatgaa cgaaggttgt 420 tttaagttgg tcacatactt tgtaatctag acatagatgc ggaagaacgg tagaaactat 480 acgaaataaa tattcagagt cctctaattg atcaagagta actattgact taataggcat 540 catttattta gtattaaatg acgaccgtac cagtgacgga tatacaaaac gatttaatta 600 cagagttttc agaagataat tatccatcta acaaaaatta tgaaataact cttcgtcaaa 660 tgtctattct aactcacgtt aacaacgtgg tagatagaga acataatgcc gccgtagtgt 720 catctccaga ggaaatatcc tcacaactta atgaagatct atttccagat gatgattctc 780 cggccactat tatcgaacga gtacaacctc atactactat tattgacgat actccacctc 840 ctacgtttcg t agagagtta ttgatatcgg aacaacgtca acaacgagaa aaaagattta 900 atattacagt atcgaaaaat gctgaagcaa taatggaatc tagatctatg atatcttcta 960 tgccaacaca aacaccatcc ttgggagtag tttatgataa agataaaaga attcagatgt 1020 tggaggatga agtggttaat cttagaaatc aacgatctaa tacaaaatca tctgataatt 1080 tagataattt taccagaata ctatttggta agactccgta taaatcaaca gaagttaata 1140 agcgtatagc catcgttaat tatgcaaatt tgaacgggtc tcccttatca gtcgaggact 1200 tggatgtttg ttcagaggat gaaatagata gaatctataa aacgattaaa caatatcacg 1260 aaagtagaaa acgaaaaatt atcgtcacta acgtgattat tattgtcata aatattatcg 1320 agcaagcatt gctaaaactc ggatttgaag aaatcaaagg actgagtacc gatatcactt 1380 cagaaattat cgatgtggag atcggagatg actgcgatgc tgtagcatca aaactaggaa 1440 tcggtaacag tccggttctt aatattgtat tgtttatact caagatattc gttaaacgaa 1500 ttaaaattat ttaatttaat acattcccat atccagacaa caatcgtctg gattaatctg 1560 ttcctgtcgt ctcataccgg acgacatatt aatcttttta ttagtaggca tctttttaga 1620 tggtttcttt ttcccagcat taactgagtc gatacctaga agatcgtgat tgatctctcc 1680 gaccattcca cgaacttct a attggccgtc tctgacggta ccataaacta ttttaccagc 1740 attagtaaca gcttggacaa tctgaccatc catcgcattg tacgatgtag tagtaactgt 1800 tgttctacgt ctaggagcac cagaagtatt tttggagccc ttggatgttg atgtagaaga 1860 agacgaggat tttgattttg gtttacatgt aatacatttt gtatcacatg cgccggcagt 1920 cacatctgtt tgagaattaa gattattgtt gcctcctttg acggctgcat ctccaccgat 1980 ttgcgctagt agatttttaa gctgtggtgt aatcttatta actgtttcga tataatcatc 2040 gtaactgctt ctaacggcta aatttttttt atccgccatt tagaagctaa aaatattttt 2100 atttatgcag aagatttaac tagattatac aatgaactaa tatgatcctt ttccagatta 2160 tttacaaact tggtattttt tggttctgga ggaggcgaat ttaaattcgg acttggattt 2220 ggattttgtg ggttcttgat cttattatac agcgcatata ggatggcgac ggtaactgct 2280 acgcaaatac cgatcaacaa aagaatacca atcatttatt gacaataact tcactattga 2340 tcaagtatgc aatatatcat cttttcacta aataagtagt aataatgatt caacaatgtc 2400 gagatatatg gacgataata atttagttca tggaaatatc gctatgattg gtatgaatga 2460 ctccgctaac tctgtggggc gcgcagtgct ttccccacat agaataaatt agcattccga 2520 ctgtgataat aataccaagt ataa acgcca taatactcaa tactttccat gtacgagtgg 2580 gactggtaga cttactaaag tcaataaagg cgaagataca cgaaagaatc aaaagaatga 2640 ttccagcgat tagcacgccg gaaaaataat ttccaatcat aagcatcata tccatttaac 2700 taataaaaat tttaaatcgc cgaatgaaca aagtggaata taaaccatat aaaaacaata 2760 gtttgtactg caaaaataat atctattttt gttttcgaag atatggtaaa attaaatagt 2820 agtacacagc atgttataac taacagcagc aacggctcgt aattacttat catttactag 2880 acgaaaaggt ggtgggatat tttcttgctc aaataatacg aatatatcac ccatccattt 2940 tatgcgatgt ttatatactc taatctttaa tagatctata gacgacgggt ttaccaacaa 3000 tatagatttt atcgattcat ctaatttaaa cccttcctta aacgtgaatg atctattatc 3060 tggcataacg atgactctac ccgatgaatc ggacaatgta ctgggccatg tagaataaat 3120 tatcaacgaa ttatcgtcta cgaacattta tatcatttgt tttaatttta gtacgcgaat 3180 aaatagatat aaaatagaaa ataacagata ttacaaccaa tgttatggcc gcgcccaacc 3240 aggtaggcag ttttatttta tcttttacta caggttctcc tggatgtacg tcaccaacgg 3300 cggacgtagt tctagtacaa ttagacgtaa gttccgcttg ggaatttttt aacgctaaag 3360 agttaacgtt aatcgtgcac ccaacgtatt tacatctagt tctttgaaca tcttgattat 3420 aatataacca ttttctatct ctagattcgt cggtgcactc atgtaaccaa cataccctag 3480 gtcctaaata tttatctccg gaattagatt ttggataatt cgcgcaccaa caatttctat 3540 ttcctttatg atcgttacaa aagacgtata atgccgtatc cccaaaagta aaataatcag 3600 gacgaataat tctaataaac tcagaacaat atctcgcatc catatgtttg gagcaaatat 3660 cggaataagt agacatagcc ggtttccgtt ttgcacgtaa ccattctaaa caattggggt 3720 ttccaggatc gtttctacaa aatccagtca tgaaatcatc acaatgttct gtcttgtaat 3780 tattattaaa tatttttgga cagtgtttgg tatttgtctt agaacaacat tttgccacgc 3840 tatcactatc gcccaggaga taatcctttt ttataaaatg acatcgttgc ccggatgcta 3900 tataatcagt agcgtgtttt aaatccttaa tatattcagg agttacctcg ttctgataat 3960 agattaatga tccaggacga aatttgaaag aactacatgg ttctccatga attaatacat 4020 attgtttagc aaattcagga actataaaac tactacaatg atctatcgac ataccatcta 4080 tcaaacaaaa cttgggttta atttctcccg gagatgtttc ataatagtac gtataacttt 4140 cttctgcaaa cttaacagct ctattatatt caggataatt aaaacctaat tccatatatt 4200 tgtctcgtat atctgctatt cctggtgcta ttttg attct attaagagta acggctgccc 4260 ccatttttaa taatcgtcag tatttaaact gttaaatgtt ggtatatcaa catttacctt 4320 atttcccgca gtataaggtt tgttgcaggt atactgttca ggaatggtta catttatact 4380 ttttctatag tcctgtcttt cgatgttcat cacatatgca aagaacagaa taaacaaaat 4440 aatgtaagaa ataatattaa atatctgtga attcgtaaat acattgattg ccataataat 4500 tacagcagct acaatacata caatagacat tcccacagtg ttgccattac ctccacgata 4560 catttgagtt actaagcaat aggtaataac taagctagta agaggcaata gaaaagatga 4620 gataaatatc atcaatatag agattagagg agggctatat agagccaaga cgaacaaaat 4680 caaaccgagt aacgttctaa catcattatt tttgaagatt cccaaataat cattcattcc 4740 tccataatcg ttttgcatca tacctccatc tttaggcata aacgattgct gctgttcctc 4800 tgtaaataaa tctttatcaa gcactccagc acccgcagag aagtcgtcaa gcatattgta 4860 atatcttaaa taactcattt atatattaaa aaatgtcact attaaagatg gagtataatc 4920 tttatgccga actaaaaaaa atgacttgtg gtcaacccct aagtcttttt aacgaagacg 4980 gggatttcgt agaagttgaa ccgggatcat cctttaagtt tctgatacct aagggatttt 5040 acgcctctcc ttccgtaaag acgagtctag tatttgaaac attaacaacg accgataata 5100 aaattactag tatcaatcca acaaatgcgc caaagttata tcctcttcaa cgcaaagtcg 5160 tatctgaagt agtttctaat atgaggaaaa tgatcgaatc aaaacgtcct ctatacatca 5220 ctcttcactt ggcgtgtgga tttggtaaga ctattaccac gtgttatctt atggctacac 5280 acggtagaaa aaccgtcatt tgcgtaccca ataaaatgtt aatacatcaa tggaagacac 5340 aggtagaggc agtcggattg gaacataaga tatccataga tggagtaagt agtctattaa 5400 aggaactaaa gactcaaagt ccggatgtat taatagtagt cagtagacat ctgacaaacg 5460 atgccttttg taaatatatc aataagcatt atgatttgtt catcttggat gaatcacata 5520 cgtataatct gatgaacaat acagcagtta caagattttt agcgtattat cctccgatga 5580 tgtgttattt tttaactgct acacctagac catctaacag aatttattgt aacagtatta 5640 ttaatattgc caagttatcc gatctaaaaa aaactatcta tgcagtagat agtttttttg 5700 agccatattc cacagataat attagacata tgataaaacg attagatgga ccatctaata 5760 aatatcatat atataccgag aagttattat ctgtagacga gcctagaaat caacttattc 5820 ttaataccct ggtagaagaa ttcaagtcag gaactattaa tcgcatttta gttattacta 5880 aactacgtga acatatggta ttcttctaca aacgattatt agattt tttc ggatcagagg 5940 ttgtatttat aggagacgcc caaaatagac gtactccaga tatggtcaaa tcaatcaagg 6000 aactaaatag atttatattc gtatccacct tattttattc cggtactggt ttagatattc 6060 ctagtttgga ttctttgttc atttgctcgg cagtaatcaa caatatgcaa atagagcaat 6120 tactagggag ggtatgtcga gaaacagaac tattagatag gacggtatat gtatttccta 6180 gcacatccat caaagaaata aagtacatga taggaaattt cgttcaacga attattagtc 6240 tgtctgtaga taaactagga tttaaacaaa aaagttatcg gaaacatcaa gaatccgatc 6300 ccacttctgt atgtacaaca tcctccagag aagaacgtgt attaaataga atatttaact 6360 cgcaaaatcg ttaagaagtt taagcgacga tccgcatgct gcgcaggcca gtgtattacc 6420 cctcatagta ttaatataat ccaatgatac ttttgtgatg tcggaaatct taaccaattt 6480 agactgacag gcagaacacg tcatgcaatc atcatcgtca tcgataactg tagtcttggg 6540 cttctttttg cggctcttca ttccggaacg cacattggtg ctatccattt aggtagtaaa 6600 aaataagtca gaatatgccc tatagcacga tcgtgcaaaa cctggtatat cgtctctatc 6660 tttatcacaa tatagtgtat cgacatcttt attattattg acctcgttta tcttggaaca 6720 tggaatggga acatttttgt tatcaacggc cacctttgcc ttaattccag a tgttgtaaa 6780 attataacta aacagtctat catcgacaca aatgaaattc ttgtttagac gtttgtagtt 6840 tacgtatgcg gctcgttcgc gtctcatttt ttcagatatt gcaggtacta taatattaaa 6900 aataagaatg aaataacata ggattaaaaa taaagttatc atgacttcta gcgctgattt 6960 aactaactta aaagaattac ttagtctgta caaaagtttg aaattttcag attctgcggc 7020 tatagaaaag tataattctt tggtagaatg gggaacatct acttactgga aaataggcgt 7080 gcaaaaggta gctaatgtcg agacgtcaat atctgattat tatgatgagg taaaaaataa 7140 accgtttaat attgatccgg gctattacat tttcttaccg gtatattttg ggagcgtctt 7200 tatttattcg aagggtaaaa atatggtaga acttggatct ggaaactctt ttcaaatacc 7260 agatgatatg cgaagtgcgt gtaacaaagt attagacagc gataacggaa tagactttct 7320 gagatttgtt ttgttaaaca atagatggat aatggaagat gctatatcaa aatatcagtc 7380 tccagttaat atatttaaac tagctagtga gtacggatta aacataccca aatatttaga 7440 aattgaaata gaggaagaca cattatttga cgacgagtta tactctatta tagaacgctc 7500 tttcgatgat aaatttccaa aaatatccat atcgtatatt aagttgggag aacttaggcg 7560 gcaagttgta gactttttca aattctcatt catgtatatt gagtccatca aggtaga tcg 7620 tataggagat aatattttta ttcctagcgt tataacaaaa tcaggaaaaa agatattagt 7680 aaaagatgta gaccatttaa tacgatccaa ggttagagaa catacatttg taaaagtaaa 7740 aaagaaaaac acattttcca ttttatacga ctatgatgga aacggaacag aaactagagg 7800 agaagtaata aaacgaatta tagacactat aggacgagac tattatgtta acggaaagta 7860 tttctctaag gttggtagtg caggcttaaa gcaattgact aataaattag atattaatga 7920 gtgcgcaact gtcgatgagt tagttgatga gattaataaa tccggaactg taaaacgaaa 7980 aataaaaaac caatcagcat ttgatttaag cagagaatgt ttgggatatc cagaagcgga 8040 ttttataacg ttagttaata acatgcggtt caaaatagaa aattgtaagg ttgtaaattt 8100 caatattgaa aatactaatt gtttaaataa cccgagtatt gagactatat atggaaactt 8160 taaccagttc gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat tattcgagtg 8220 aaataatatg cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt ttagaagtca 8280 aggataactc cgttagggta ttggatatat caaaattaga ctggagttct gattgggaaa 8340 ggcacatagc taaagatttg tcacaatatg aatacactac agttcttcta gaacgtcagc 8400 ctagaaggtc gccgtacgtc aaatttatct attttattaa aggcttttta tatcatacat 84 60 cggctgccaa agttatttgc gtctcgcctg tcatgtctgg taattcatat agagatcgaa 8520 aaaagagatc ggtcgaagca tttcttgatt ggatggacac attcggattg cgagactccg 8580 ttccggatag acgcaaatta gacgatgtag cggatagttt caatttggct atgagatacg 8640 tattagataa atggaatact aattatacac cttataatag gtgtaaatct agaaattaca 8700 taaaaaaaat gtaataacgt tagtaacgcc attatggata atctatttac ctttctacat 8760 gaaatagaag atagatatgc cagaactatt tttaactttc atctaataag ttgcgatgaa 8820 ataggagata tatatggtct tatgaaagaa cgcatttcct cagaggatat gtttgataat 8880 atagtgtata ataaagatat acatcatgcc attaagaaac tagtgtattg cgacatccaa 8940 cttactaaac acattattaa tcagaatacg tatccggtat ttaacgattc ttcacaagtg 9000 aaatgttgtc attatttcga tataaactca gataatagca atattagctc tcgtacagta 9060 gagatatttg agagggaaaa gtcatctctt gtatcatata ttaaaactac caataagaag 9120 agaaaggtca attatgggga aataaagaaa actgtacatg gaggcactaa tgcaaattac 9180 ttttccggta aaaagtctga tgagtatctg agcactacag tcaggtccaa cattaatcaa 9240 ccttggatca aaaccatttc taagagaatg agagtagata tcattaatca ctctatagta 9300 acg cgtggaa aaagctctat attacaaact atagaaatta tttttactaa tagaacatgt 9360 gtgaaaatat tcaaggattc tactatgcac attattctat ccaaggacaa ggatgaaaag 9420 gggtgtatac acatgattga caaattattc tatgtctatt ataatttatt tctgttgttc 9480 gaggatatca tccaaaacga gtactttaaa gaagtagcta atgttgtaaa ccacgtactc 9540 acggctacgg cattagatga gaaattattc ctaattaaga aaatggctga acacgatgtt 9600 tatggagtta gcaatttcaa aatagggatg tttaacctga catttattaa gtcgttggat 9660 cataccgttt tcccctctct gttagatgag gatagcaaaa taaagttttt taaggggaaa 9720 aagctcaata ttgtagcatt acgatctctg gaggattgta taaattacgt gactaaatcc 9780 gagaatatga tagaaatgat gaaggaaaga tcgactattt taaatagcat agatatagaa 9840 acggaatcgg tagatcgtct aaaagaattg cttctaaaat gaaaaaaaaa cactaattca 9900 gaaatggatc aacgactcgg atataagttt ttggtgcctg atcctaaagc cggagttttt 9960 tatagaccgt tacatttcca atatgtatcg tattctaatt ttatattgca tcgattgcat 10020 gaaatcttga ccgtcaagcg gccactctta tcgtttaaga ataatacaga acgaattatg 10080 atagaaatta gcaatgttaa agtgactcct ccagattact cacctataat cgcgagtatt 10140 aaaggt aaga gttatgacgc attagccacg ttcactgtaa atatctttaa agaggtaatg 10200 accaaagagg gtatatccat cactaaaata agtagttatg agggaaaaga ttctcatttg 10260 ataaaaattc cgctactaat aggatacggg aataaaaatc cacttgatac agccaagtat 10320 cttgttccta atgtcatagg tggagtcttt atcaataaac aatctgtcga aaaagtagga 10380 attaatctag tagaaaagat tacaacatgg ccaaaattta gggttgttaa gccaaactca 10440 ttcactttct cgttttcctc cgtatcccct cctaatgtat taccgacaag atatcgccat 10500 tacaagatat ctctggatat atcacaattg gaagcgttga atatatcatc gacaaagaca 10560 tttataacgg tcaatattgt tttgctgtct caatatttat ctagagtgag tctagaattc 10620 attagacgta gtttatcata cgatatgcct ccagaagttg tctatctagt aaacgcgata 10680 atagatagtg ctaaacgaat tactgaatct attactgact ttaatattga tacatacatt 10740 aatgacctgg tggaagctga acacattaaa caaaaatctc agttaacgat caacgagttc 10800 aaatatgaaa tgctgcataa ctttttacct catatgaact atacacccga tcaactaaag 10860 ggattttata tgatatcttt actaagaaag tttctctact gtatctacca cacttctaga 10920 tatccagata gagattcgat ggtttgtcat cgcatcctaa cgtacggcaa atattttgag 1098 0 acgttggcac atgatgaatt agagaattac ataggcaaca tccgaaacga tatcatgaac 11040 aatcacaaga acagaggcac ttacgcggta aacattcatg tactaacaac tcctggactt 11100 aatcatgcat tttctagtct attgagtgga aagttcaaaa agtcagacgg tagttatcga 11160 acacatcctc actattcatg gatgcagaat atttctattc ctaggagtgt tggattttat 11220 ccggatcaag taaagatttc aaagatgttt tctgtcagaa aataccatcc aagtcaatat 11280 ctttactttt gttcatcgga cgttccggaa agaggtcctc aggtaggttt agtatctcaa 11340 ttgtctgtct tgagttccat tacaaatata ctaacgtctg agtatttgga tttggaaaag 11400 aaaatttgtg agtatatcag atcatattat aaagatgata taagttactt tgaaacagga 11460 tttccaatca ctatagaaaa tgctctagtc gcatctctta atccaaatat gatatgtgat 11520 tttgtaactg actttagacg tagaaaacgg atgggattct tcggtaactt ggaggtaggt 11580 attactttag ttagggatca catgaatgaa attcgcatta atattggagc gggaagatta 11640 gtcagaccat tcttggttgt ggataacgga gagctcatga tggatgtgtg tccggagtta 11700 gaaagcagat tagacgacat gacattctct gacattcaga aagagtttcc gcatgtcatc 11760 gaaatggtag atatagaaca atttactttt agtaacgtat gtgaatcggt tcaaaaa ttt 11820 agaatgatgt caaaggatga aagaaagcaa tacgatttat gtgactttcc tgccgaattt 11880 agagatggat atgtagcatc ttcactagtg ggaatcaatc acaattctgg acccagagct 11940 attcttggat gtgctcaagc taaacaagct atctcttgtc tgagctcgga tatacgaaat 12000 aaaatagaca atggaattca tttgatgtat ccagagaggc caatcgtgat tagtaaggct 12060 ttagaaactt caaagattgc ggctaattgc ttcggccaac atgttactat agcattaatg 12120 tcgtacaaag gtatcaatca agaggatgga attatcatca aaaaacaatt tattcagaga 12180 ggcggtctcg atattgttac agccaagaaa catcaagtag aaattccgtt ggaaaacttt 12240 aataacaaag aaagagatag gtctaacgcc tattcaaaat tagaaagtaa tggattagtt 12300 agactgaatg ctttcttgga atccggagac gctatagcac gaaatatctc atcaagaact 12360 cttgaagatg attttgctag agataatcag attagctttg atgtttccga aaaatatacc 12420 gatatgtaca aatctcgcgt tgaacgagta caagtagaac ttactgacaa agttaaggta 12480 cgagtattaa ccatgaaaga aagaagaccc attctaggag acaaatttac cactagaacg 12540 agtcaaaagg gaacagtcgc gtatatcgcg gatgaaacgg aacttccata cgatgaaaat 12600 ggtatcacac cagatgtcat tattaattct acatccatct tctctagaaa aactatatct 12660 atgttgatag aggttatttt aacagccgca tattctgcta agccgtacaa caataaggga 12720 gaaaaccgac ctgtctgttt tcctagtagt aacgaaacat ccatcgatac atatatgcaa 12780 ttcgctaaac aatgttatga gcattcaaat ccgaaattgt ctgatgaaga attatcggat 12840 aaaatctttt gtgaaaagat tctctatgat cctgaaacgg ataagcctta tgcatccaaa 12900 gtattttttg gaccaattta ttacttgcgt ctgaggcatt taactcagga caaggcaacc 12960 gttagatgta gaggtaaaaa gacgaagctc attagacagg cgaatgaggg acgaaaacgt 13020 ggaggaggta tcaagttcgg agaaatggag agagactgtt taatagcgca tggtgcagcc 13080 aatactatta cagaagtttt gaaagattcg gaagaagatt atcaagatgt gtatgtttgt 13140 gaaaattgtg gagacatagc agcacaaatc aagggtatta atacatgtct tagatgttca 13200 aaacttaatc tctctcctct cttaacaaaa attgatacca cgcacgtatc taaagtattt 13260 cttactcaaa tgaacgccag aggcgtaaaa gttaaattag atttcgaacg aaggcctcct 13320 tcgttttata aaccattaga taaagttgat ctcaaaccgt cttttctggt gtaatattct 13380 agtttggtag tagatacata tcaatatcat caaattcgag atccgaatta taaaatgggc 13440 gtggattgtt aactatagaa tcggacgtct gatattcgaa aa tctgtgga gttttaggtt 13500 ttggtggagg tgtaactgct acttgggata ctgaagtctg atattcagaa agctggggga 13560 tgttctggtt cgacatccac cgatggtgtc acatcactcactaa tcggtacatcggt tggct gacgtcattggt ttaggt gacgtcattggt 13620 gacctctgtgt acttcaatgc gaggaaatgt ataatttggt aatggtttct catgtggatc tgaagaagag 13740 gtaagatatc tactagaaag ataccgatca cgttctagtt ctcttttgta gaacttaact 13800 ttttctttct ccgcatctag ttgatattcc aacctcttca cgttcgcatg ggttacctcc 13860 gcagttttta cgagcgattt cacgttcagc cttcatgcgt cttatagcat gaattcgctt 13920 atcgttatcg ggtttagctt ctgtcacctt agcaattcct tttttattaa actctacata 13980 atcatatcca tttctattgt ttgttctaat ataaacgagt atagcatcat tgctaaattt 14040 ttcaatagta tcgaaaacag aatatcctaa accatataat atatattcag gaacactcaa 14100 actaaatgtc caggattctc ctaaatacgt aaactttaat agtgcgaaat cattcaaaaa 14160 tctaccactt atagatagat agatagtaca taaatgcgta tagtagtcta cctatctctt 14220 tattatgaaa accggcatta cgatcatata tgtcgtgata tacctgtgat ccgtttacgt 14280 taaaccataa atacatgggt gatcctataa acatgaattt atttctaatt ctcagagcta 14340 tagttaattg accgtgtaat atttgcttac atgcatactt gatacgatca ttaataagat 14400 ttttatcatt gctcgttatt tcagaatcgt atatataagg agtaccatcg tgattcttac 14460 cagatattat acaaaatact atatataaaa tatattgacc cacgttagta atcatgtaa a 14520 tgtttaacgt tttaaatttt gtattcaatg atccattatc atacgctagc atggtcttat 14580 gatattcatt ctttaaaata taatattgtg ttagccattg cattggggct cctaatggag 14640 attttttatt ctcatccatt ttaggatagg ctttcataaa gtccctaata acttcgtgaa 14700 taatgtttct atgttttcta ctgatgcatg tatttgcttc gattttttta tcccatgttt 14760 catctatcat agatttaaac gcagtaatgc tcgcaacatt aacatcttga accgttggta 14820 caattccgtt ccataaattt ataatgttcg ccatttatat aactcatttt ttgaatatac 14880 ttttaattaa caaaagagtt aagttactca tatggacgcc gtccagtctg aacatcaatc 14940 tttttagcca gagatatcat agccgctctt agagtttcag cgtgattttc caacctaaat 15000 agaacttcat cgttgcgttt acaacacttt tctatttgtt caaactttgt tgttacatta 15060 gtaatctttt tttccaaatt agttagccgt tgtttgagag tttcctcatt gtcgtcttca 15120 tcggctttaa caattgcttc gcgtttagcc tctggctttt tagcagccgt tgtagaaaaa 15180 aattcagttg ctggaattgc aagatcgtca tctccgggga aaagagttcc gtccatttaa 15240 agtacagatt ttagaaactg acactctgcg ttatttatat ttggtacaac acatggatta 15300 taaatattga tgttaataac atcagaaaat gtaaagtcta tacattgttg c atcgtgtta 15360 aattttctaa tggatctagt attattgggt ccaacttctg cctgaaatcc aaatatggaa 15420 gcggatacaa aaccgtttcc tggataaacc acacatctcc acttttgctt tacatcagaa 15480 attgtgtcgt tgacatcttg aactctccta tctaatgccg gtgttccacc tatagatttt 15540 gaatattcga atgctgcatg agtagcatta aattccttaa tattgccata attttcatat 15600 attgagtaac cctggataaa aagtaaacac accgcagccg tagctaccac aataaaaaaa 15660 attgatagag agttcattta taatctatta gaagctgaca aaattttttt acacgcatca 15720 gacaatgctt taataaatag ttcaacatct acttttgtca tatcgaaccg atggtatgat 15780 tctaacctag aattacatcc gaaaaagttg actatgttca tagtcattaa gtcattaaca 15840 aacaacattc cagactctgg attataagac gatactgttt cgtcacaatt acctacctta 15900 atcatgtgat tatgaatatt ggctattaga gcaccttcta agaaatctat aatatctttg 15960 aaacacgatt taaaatcaaa ccacgaatat acttctacga agaaagttag tttacccata 16020 ggagaaataa ctataaatgg agatctaaat acaaaatccg gatctatgat agttttaaca 16080 ttattatatt ctctattaaa tacctccaca tctaaaaatg ttaattttga aactatgtct 16140 tcgtttatta ccgtacctga actaaacgct ataagctcta ttgt ttgaga actctttaaa 16200 cgatattctt gaaatacatg taacaaagtt tcctttaact cggtcggttt atctaccata 16260 gttacagaat ttgtatcctt atctataata taataatcaa aatcgtataa agttatataa 16320 ttatcgcgtt cagattggga tcttttcaaa tagactaaaa accccatttc tctagtaagt 16380 atcttatgta tatgtttgta aaatatcttc atggtgggaa tatgctctac cgcagttagc 16440 cattcctcat tgacagcggt agatgtatta gacaaaacta ttccaatgtt taacaagggc 16500 cattttacga gattattaaa tccttgtttg ataaatgtag ccaatgaggg ttcgagttca 16560 acgacgattg aattctcttc ccgcggatgc tgcatgatga acgacgggat gttgttcgat 16620 tgatttggaa ttctttttcg actttttgtt tatattaaat attttaaaat ttatagcgga 16680 tagcaattca tgtaccacgg ataatgtaga cgcgtattgc gcatcgatat ctttattatt 16740 agataaattt atcaataaat gtgagaagtt tgcctcgtta aggtcttcca tttaaatatt 16800 atataaacat ttgtgtttgt atcttattcg tcttttatgg aatagttttt tactagtaaa 16860 gctgcaatta cacactttgt ccgtaaaaca taaatataaa caccagcttt tatcaatcgt 16920 tccaaaaagt cgacggcgga catttttaac atggcatcta ttttaaatac acttaggttt 16980 ttggaaaaaa catcatttta taattgtaac gattcaa taa ctaaagaaaa gattaagatt 17040 aaacataagg gaatgtcatt tgtattttat aagccaaagc attctaccgt tgttaaatac 17100 ttgtctggag gaggtatata tcatgatgat ttggttgtat tggggaaggt aacaattaat 17160 gatctaaaga tgatgctatt ttacatggat ttatcatatc atggagtgac aagtagtgga 17220 acaatttaca aattgggatc gtctatcgat agactttctc taaataggac tattgttaca 17280 aaagttaata attataatta tgatacattt tttgacgatg atgattgatc gctattgcac 17340 aattttgttt ttttactttc taatatagcg tttagattct ttttcatgtg cgaatattga 17400 tttactaaaa tatctatgtt taacttttgt tctataacgt ccttatcggc ggtatcggta 17460 catatacgta attcaccttc acaaaatacg gagtcttcga taataatagc caatcgatta 17520 ttggatctag ctgtctgtat catattcaac atgtttaata tatcctttcg tttccccttt 17580 acaggcatcg atcgtagcat attttccgcg tctgagatgg aaatgttaaa actacaaaaa 17640 tgcgtaatgt tagcccgtcc taatattggt acgtgtctat aagtttggca tagtagaata 17700 atagacgtgt ttaaatgcct tccaaagttt aagaattcta ttagagtatt gcattttgat 17760 agtttatcgc ctacatcatc aaaaataagt aaaaagtgtg ctgatttttt atgattttgt 17820 gcgacagcaa tacatttttc tatgttactt ttagttcgta tcagattata ttctagagat 17880 tcctgactac taacgaaatt aatatgattt ggccaaatgt atccatcata atctggatta 17940 taaacgggtg taaacaagaa tacatgttta tattttttaa ctagtgtaga aaacagagat 18000 agtaaataga tagtttttcc agatccagat cctcccgtta aaaccattct aaacggcatt 18060 tttaataaat tttctcttga aaattgtttt tcttggaaac aattcataat tatatttaca 18120 gttactaaat taatttgata ataaatcaaa atatggaaaa ctaaggtcgt tagtagggag 18180 gagaacaaag aaggcacatc gtgacataaa taacatttat tatcatgatg acaccagaaa 18240 acgacgaaga gcagacatct gtgttctccg ctactgttta cagagacaaa attcagggaa 18300 agaataaacg caaacgcgtg attggtctat gtattagaat atctatggtt atttcactac 18360 tatctatgat taccatgtcc gcgtttctca tagtgcgcct aaatcaatgc atgtctgcta 18420 acgaggctgc tattactgac gccgctgttg ccgttgctgc tgcatcatct actcatagaa 18480 aggttgcgtc tagcactacg caatatgatc acaaagaaag ctgtaatggt ttatattacc 18540 agggttcttg ttatatatta cattcagact accagttatt ctcggatgct aaagcaaatt 18600 gcactgcgga atcatcaaca ctacccaata aatccgatgt cttgactacc tggctcattg 18660 attatgttaa ggatacatgg gg atctgatg gtaatccaat tacaaaaact acatccgatt 18720 atcaagattc tgatgtatca caagaagtta gaaagtattt ttgtgttaaa acaatgaact 18780 aatatttatt tttgtacatt aataaatgaa atcgcttaat agacaaactg taagtaggtt 18840 taagaagttg tcggtgccgg tcgctataat gatgatactc tcaaccatta ttagtggcat 18900 aggaacattt ctgcattaca aagaagaact gatgcctagt gcttgcgcca atggatggat 18960 acaatacgat aaacattgtt atttagatac taacattaaa atgtctacag ataatgcggt 19020 ttatcagtgt cgtaaattac gagccagatt gcctagaccg gatactagac atctgagagt 19080 attgtttagt attttttata aagattattg ggtaagttta aaaaagacca atgataaatg 19140 gttagatatt aataatgata aagatataga tattagtaaa ttaacaaatt ttaaacaact 19200 aaacagtacg acggatgctg aagcgtgtta tatatacaag tctggaaaac tggttaaaac 19260 agtatgtaaa agtactcaat ctgtactatg tgttaaaaaa ttctacaagt gacaacaaaa 19320 aatgaattaa taataagtcg ttaacgtacg ccgccatgga cgccgcgttt gttattactc 19380 caatgggtgt gttgactata acagatacat tgtatgatga tctcgatatc tcaatcatgg 19440 actttatagg accatacatt ataggtaaca taaaaactgt ccaaatagat gtacgggata 19500 taaaatattc cgaca tgcaa aaatgctact ttagctataa gggtaaaata gttcctcagg 19560 attctaatga tttggctaga ttcaacattt atagcatttg tgccgcatac agatcaaaaa 19620 ataccatcat catagcatgc gactatgata tcatgttaga tatagaagat aaacatcagc 19680 cattttatct attcccatct attgatgttt ttaacgctac aatcatagaa gcgtataacc 19740 tgtatacagc tggagattat catctaatca tcaatccttc agataatctg aaaatgaaat 19800 tgtcgtttaa ttcttcattc tgcatatcag acggcaatgg atggatcata attgatggga 19860 aatgcaatag taatttttta tcataaaagt tgtaaagtaa ataataaaac aataaatatt 19920 gaactagtag tacgtatatt gagcaatcag aaatgatgct ggtacctctt atcacggtga 19980 ccgtagttgc gggaacaata ttagtatgtt atatattata tatttgtagg aaaaagatac 20040 gtactgtcta taatgacaat aaaattatca tgacaaaatt aaaaaagata aagagttcta 20100 attccagcaa atctagtaaa tcaactgata gcgaatcaga ctgggaggat cactgtagtg 20160 ctatggaaca aaacaatgac gtagataata tttctaggaa tgagatattg gacgatgata 20220 gcttcgctgg tagtttaata tgggataacg aatccaatgt tatggcgcct agcacagaac 20280 acatttacga tagtgttgct ggaagcacgc tgctaataaa taatgatcgt aatgaacaga 20340 ctatttat ca gaacactaca gtagtactta atgaagatac caaacagaat cctaactatt 20400 catccaatcc tttcgtaaat tataataaaa ccagtatttg tagcaagtca aatccgttca 20460 ttacagaact caacaataaa tttagtgaga ataatccgtt tagacgagca catagcgatg 20520 attatcttaa taagcaagaa caagatcatg aacacgatga tatagaatca ttggtgtgat 20580 tagtttcctt tttataaaat tgaagtaata tttagtatta ttgctgccgt cacgttgtac 20640 aaatggagat attccctgta ttcggcattt ctaaaattag caattttatt gctaataatg 20700 actgtagata ttatatagat acagaacatc aaaaaattat atctgatgag atcaatagac 20760 agatggatga aacggtactt cttaccaaca tcttaagcgt agaagttgta aatgacaatg 20820 agatgtacca tcttattcct catagattat cgacgattat actctgtatt agttctgtcg 20880 gaggatgtgt tatctctata gataatgacg tcaatggcaa aaatattcta acctttccca 20940 ttgatcatgc tgtaatcata tccccactga gtaaatgtgt cgtagttagc aagggtccta 21000 caaccatatt ggttgttaaa gcggatatac ctagcaaacg attggtaaca tcgtttacaa 21060 acgacatact gtatgtaaac aatctatcac tgattaatta ttcgccgttg tctgtattca 21120 ttattagacg agttaccgac tatttggata gacacatatg cgatcagata tttgcgaata 21180 ataagtggta ttccattata accatcgaca ataagcagtt tcctattcca tcaaactgta 21240 taggtatgtc ctctgccaag tacataaatt ctagcatcga gcaagatact ttaatacatg 21300 tttgtaacct cgagcatcca ttcgacttag tatacaaaaa aatgcagtcg tacaattctg 21360 tacctatcaa ggaacaaata ttgtacggta gaattgataa tataaatatg agcattagta 21420 tttctgtgga ttaatagatt tctagtatgg ggatcattaa tcatctctaa tctctaaata 21480 cctcataaaa cgaaaaaaaa gctattatca aatactgtac ggaatggatt cattctcttc 21540 tctttttatg aaactctgtt gtatatctac tgataaaact ggaagcaaaa aatctgataa 21600 aaagaataag aataagatca aggattatta taaaataaca atagttcctg gttcctcttc 21660 cacgtctact agctcgtggt attatacaca tgcctagtaa tagtctcttt gcgttgacgg 21720 aaagcagact agaaataaca ggctaaaatg ttcagacacc ataatagttc ccaacccaga 21780 taataacaga gtaccatcaa cacattcctt taaactcaat cccaaaccca aaaccgttaa 21840 aatgtatccg gccaattgat agtagataat gaggtgtaca gcgcatgatg atttacacag 21900 taaccaaaat gaaaatactt tagtaattat aagaaatata gatggtaacg tcatcatcaa 21960 caatccaata atatgccgga gagtaaacat tgacggataa aacaaaaatg ctccgcata a 22020 ctctatcatg gcaataacac aaccaaatac ttgtaagatt cctaaattag tagaaaatac 22080 aacggatatc gatgtataag tgatctcgag aaataataag aataaagtaa tgcccgtaaa 22140 gataaacatc aacattgttt ggtaatcatt aaaccaatta gtatgaagtt gaactaattt 22200 cacagtagat tttattccag tattatcccc gcatgtataa gtacctggta agatatcttt 22260 atattccata atcaatgaga catcactatc tgataacgaa tgaagtctag cactagtatg 22320 ccatttactt aatattgtcg tcttggaagt tttattataa gttaaaatat catggttatc 22380 caatttccat ctaatatact ttgtcggatt atctatagta cacggaataa tgatggtatc 22440 attacatgct gtatactcta tggtctttgt agttgttata acaaccaacg tatagaggta 22500 tatcaacgat attctaactc ttgacatttt ttatttattt aaaatgatac ctttgttatt 22560 tattttattc tattttgcta acggtattga atggcataag tttgaaacga gtgaagaaat 22620 aatttctact tacttattag acgacgtatt atacacgggt gttaatgggg cggtatacac 22680 attttcaaat aataaactaa acaaaactgg tttaactaat aataattata taacaacatc 22740 tataaaagta gaggatgcgg aaccaataac ggaaatccca aatgttggaa aatagacggt 22800 tcagacgacc caaaacatag aggtagagga tacgctcctt atcaaaatag c aaagtaacg 22860 ataatcagtc acaacggatg tgtactatct gacataaaca tatcaaaaga aggaattaaa 22920 cgatggagaa gatttgacgg accatgtggt tatgatttat acacggcgga taacgtaatt 22980 ccaaaagatg gtttacgagg agcattcgtc gataaagatg gtacttatga caaagtttac 23040 attcttttca ctgatactat cggctcaaag agaattgtca aaattccgta tatagcacaa 23100 atgtgcctaa acgacgaagg tggtccatca tcattgtcta gtcatagatg gtcgacgttt 23160 ctcaaagtcg aattagaatg tgatatcgac ggaagaagtt atagacaaat tattcattct 23220 agaactataa aaacagataa tgatacgata ctatatgtat tcttcgatag tccttattcc 23280 aagtccgcat tatgtaccta ttctatgaat accattaaac aatctttttc tacgtcaaaa 23340 ttggaaggat atacaaagca attgccgtct ccagctcctg gtatatgttt accagctgga 23400 aaagttgttc cacataccac gtttgaagtc atagaaaaat ataatgtact agatgatatt 23460 ataaagcctt tatctaacca acctatcttc gaaggaccgt ctggtgttaa atggttcgat 23520 ataaaggaga aggaaaatga acatcgggaa tatagaatat acttcataaa agaaaattct 23580 atatattcgt tcgatacaaa atctaaacaa actcgtagct cgcaagtcga tgcgcgacta 23640 ttttcagtaa tggtaacttc gaaaccgtta tttatagcag atat agggat aggagtagga 23700 atgccacaaa tgaaaaaaat acttaaaatg taatcttaat cgagtacacc gcacgacaat 23760 gaacaaacat aagacagatt atgctggtta tgcttgctgc gtaatatgcg gtctaattgt 23820 tggaattatt tttacagcga cactattaaa agttgtagaa cgtaaattag ttcatacacc 23880 atcaatagat aaaacgataa aagatgcata tattagagaa gattgtccta ctgactggat 23940 aagctataat aataaatgta tccatttatc tactgatcga aaaacctggg aggaaggacg 24000 taatgcatgc aaagctctaa atccaaattc ggatctaatt aagatagaga ctccaaacga 24060 gttaagtttt ttaagaagca ttagacgcgg atattgggta ggagaatccg aaatattaaa 24120 ccagacaacc ccatataatt ttatagctaa aaatgccacg aagaatggaa ctaaaaaacg 24180 gaaatatatt tgtagtacaa cgaatactcc caaactacat ttttatcata ccactacttc 24240 ggttagatgt tttagaaaaa aataaatatc gccgtaccgt tcttgttttt ataaaaataa 24300 caattaacaa ttatcaaatt ttttctttaa tattttacgt ggttgaccat tcttggtggt 24360 aaaataatct cttagtgttg gaatggaatg ctgtttaatg tttccgcact catcgtatat 24420 tttgacgtat gcagtcacat cgtttacgca atagtcagac tgtagttcta tcatgcttcc 24480 tacatcagaa ggaggaacag ttttaaagtc tcttggt ttt aatctattgc cattagtttt 24540 catgaaatcc tttgttttat ccacttcaca ttttaaataa atgtccacta tacattcttc 24600 tgttaatttt actagatcgt catgggtcat agaatttata ggttccgtag tccatggatc 24660 caaactagca aacttcgcgt atacggtatc gcgattagtg tatacaccaa ctgtatgaaa 24720 attaagaaaa cagtttaata aatcaacaga aatatttaat cctccgtttg atacagatgc 24780 gccatattta tggatttcgg attcacacgt tgtttgtctg aggtgttcgt ctagtgttgc 24840 ttctacgtaa acttcgattc ccatatattc tttattgtca gaatcgcata ccgatttatc 24900 atcatacact gtttgaaaac taaatggtat acacatcaaa ataataaata ataacgagta 24960 cattctgcaa tattgttatc gtaattggaa aaatagtgtt cgagtgagtt ggattatgtg 25020 agtattggat tgtatatttt attttatatt ttatattttg tagtaagaat agaatgctaa 25080 tgtcaagttt attccaatag atgtcttatt aaaaaacata tataataaat aacaatggct 25140 gaatggcata aaattatcga ggatatctca aaaaataata agttcgagga tgccgccatc 25200 gttgattaca agactacaaa gaatgttcta gctgctattc ctaacagaac atttgccaag 25260 attaatcctc tcatcactaa tcgtaatatt ctaaaacctc ttattggtca gaaatattgt 25320 attgtatata ctaactctct aatggatgag aacacgtatg ctatggagtt gcttactggg 25380 tacgcccctg tatctccgat cgttatagcg agaactcata ccgcacttat atttttgatg 25440 ggtaagccaa caacatccag acgtgacgtg tatagaacgt gtagagatca cgctacccgt 25500 gtacgtgcaa ctggtaatta aaataaaaag taatattcat atgtagtgtc aattttaaat 25560 gatgatgatg aaatggataa tatccatatt gacgatgtca ataatgccgg tattggcata 25620 cagttcatcg atttttagat ttcattcaga ggatgtggaa ttatgttatg ggcatttgta 25680 ttttgatagg atctataatg tagtaaatat aaaatataat ccgcatattc catatagata 25740 taattttatt aatcgcacgt taaccgtaga tgaactagac gataatgtct tttttacaca 25800 tggttatttt ttaaaacaca aatatggttc acttaatcct agtttgattg tctcattatc 25860 aggaaactta aaatataatg atatacaatg ctcagtaaat gtatcgtgtc tcattaaaaa 25920 tttggcaacg agtacatcta ctatattaac atctaaacat aagacttatt ctctacatcg 25980 gtccacgtgt attactataa taggatacga ttctattata tggtataaag atataaatga 26040 catctatgat tttactgcaa tatgtatgct aatagcgtct acattgatag tgaccatata 26100 cgtgtttaaa aaaataaaaa tgaactctta attatgctat gctattagaa atggataaaa 26160 tcaaaattac ggttgattca aa aattggta atgttgttac catatcgtat aacttggaaa 26220 agataactat tgatgtcaca cctaaaaaga aaaaagaaaa ggatgtatta ttagcgcaat 26280 cagttgctgt cgaagaggca aaagatgtca aggtagaaga aaaaaatatt atcgatattg 26340 aagatgacga tgatatggat gtagaaagcg cataatacga tctataaaaa taagtatata 26400 aatacttttt atttactgta ctcttactgt gtagtggtga taccctactc gattattttt 26460 ttaaaaaaaa atacttattc tgattcttct agccatttcc gtgttcgttc gaatgccaca 26520 tcgacgttaa agatagggga gtagttgaaa tctagttctg cattgttggt acgcacctca 26580 aatgtagtgt tggatatctt caacgtatag ttgttgagta gtgatggttt tctaaataga 26640 attctcttca tatcattctt gcacgcgtac atttttagca tccatcttgg aatcctagat 26700 ccttgttcta ttcccaatgg tttcatcaat agaagattaa acatatcgta cgaacacgat 26760 ggagagtaat cgtagcaaaa gtaagcattt cctttaatct cagatcccgg atactggata 26820 tattttgcag ccaacacgtg catccatgca gcatttccta catatacccg gctatgtacc 26880 gcgttatcat cgactgtacg atacataatg ttaccgtgtt gcttacattg ctcgtaaaag 26940 actttcatca atttgtctcc ttctccgtaa attccagtgg gtcttaggca acaagtatac 27000 aattttgctc cattc atgat tacggaatta ttggctttca taaccagttg ctcggccata 27060 cgtttacttt ttgcgtatac atgtcctggt gatatatcat aaagggtatg ctcatggccg 27120 atgaatggat caccgtgttt attgggtcct attgcttcca tgctactagt atagatcaaa 27180 tacttgattc ctaggtccac acaagctgcc aatatagtct gtgttccata atagtttact 27240 ttcatgattt cattatcggt gtattttcca aatacatcca ctagagcagc tgtatgaata 27300 atcagattta ccccatctag cgcttctctt accttatcaa agtcgtttat atcacattgt 27360 atatagttta taaccttaac tttcgaggtt attggttgtg gatcttctac aatatctatg 27420 actctgattt cttgaacatc atctgcacta attaacagtt ttactatata cctgcctaga 27480 aatccggcac caccagtaac cgcgtacacg gccattgctg ccactcataa tatcagacta 27540 cttattctat tttactaaat aatggctgtt tgtataatag accacgataa tatcagagga 27600 gttatttact ttgaaccagt ccatggaaaa gataaagtta ttggattaaa atccggaacg 27660 tatagtttga taattcatcg ttacggagat attagtcaag gatgtgattc cataggcagt 27720 ccagaaatat ttatcggtaa catctttgta aacagatatg gtgtagcata tgtttattta 27780 gatacagatg taaatatatc tacaattatt ggaaaggcgt tatctatttc aaaaaatgat 27840 cagagattag cgtgtggagt tattggtatt tcttacataa atgaaaagat aatacatttt 27900 cttacaatta acgagaatgg cgtttgatat atcagttaat gcgtctaaaa caataaatgc 27960 attagtttac ttttctactc agcaaaataa attagtcata cgtaatgaag ttaatgatac 28020 acactacact gtcgaatttg atagggacaa agtagttgac acgtttattt catataata g 28080 acataatgac tccatagaga taagaggggt gcttccagag gaaactaata ttggttgcgc 28140 ggttaatacg ccggttagta tgacttactt gtataataag tatagtttta aactgatttt 28200 agcagaatat ataagacaca gaaatactat atccggcaat atttattcgg cattgatgac 28260 actagatgat ttggctatta aacagtatgg agacattgat ctattattta atgagaaact 28320 taaagtagac tccgattcgg gactatttga ctttgtcaac tttgtaaagg atatgatatg 28380 ttgtgattct agaatagtag tagctctatc tagtctagta tctaaacatt gggaattgac 28440 aaataaaaaa tataggtgta tggcattagc cgaacatata tctgatagta ttccaatatc 28500 tgagctatct agactacgat acaatctatg taagtatcta cgcgggcaca ctgagagcat 28560 agaggatgaa tttgattatt ttgaagacga tgattcgtct acatgttctg ccgtaaccga 28620 cagggaaacg gatgtataat tttttttata gcgtgaagga tatgataaaa aatataattg 28680 ttgtatttat cccattccaa tcaccttata tgattctgta acacaatgaa ggagtcttat 28740 agatgtatag aggtcagata ctggtttgat aaactgttta ttccacataa gtatgtttga 28800 ctttatggtt agacccgcat actttaacaa atcactgaaa attggagtta ggtattgacc 28860 tctcagaatc agttgccgtt ctggaacatt aaatgtattt tttatgatat a ctccaacgc 28920 atttatgtgg gcatacaaca agtcattact aatggagtat tccaagagaa gagatttcaa 28980 cagactgttt atgaactcga atgccgcctc attgtcgctt atattgatga tgtcgaattc 29040 tcccaatatc atcaccgatg agtagctcat cttgttatcg ggatccaagt tttctaaaga 29100 tgtcattaaa ccctcgatca tgaatggatt tatcatcatc gtttttatgt tggacatgag 29160 cttagtccgt ttgtccacat ctatagacga cgatttctga attatttcat atatccctct 29220 ctttaactcc aggaacttgt caggatggtc tactttaata tgttctcgtc taagagatga 29280 aaatctttgg atggttgcac gcgacttttc tctaaaggat cctctcttaa atgaatccat 29340 cttatccttg gacaagatgg acagtctatt ttccttagat ggtttaatat ttttgttacc 29400 catgatctat aaaggtagac ctaatcgtct cggatgacca tatatttatt ttcagtttta 29460 ttatacgcat aaattgtaaa aaatatgtta ggtttacaaa aatgtctcgt ggggcattaa 29520 tcgtttttga aggattggac aaatctggaa aaacaacaca atgtatgaac atcatggaat 29580 ctataccggc aaacacgata aaatatctta actttcctca gagatccact gtcactggaa 29640 agatgataga tgactatcta actcgtaaaa aaacctataa tgatcatata gttaatctat 29700 tattttgtgc aaatagatgg gagtttgcat cttttataca agaa caacta gaacagggaa 29760 ttactttaat agttgataga tacgcattct ctggagtagc gtatgccgcc gctaaaggcg 29820 cgtcaatgac tctcagtaag agttatgaat ctggattgcc taaacccgac ttagttatat 29880 tcttggaatc tggtagcaaa gaaattaata gaaacgtcgg cgaggaaatt tatgaagatg 29940 ttacattcca acaaaaggta ttacaagaat ataaaaaaat gattgaagaa ggagatattc 30000 attggcaaat tatttcttct gaattcgagg aagatgtaaa gaaggagttg attaagaata 30060 tagttataga ggctatacac acggttactg gaccagtggg gcaactgtgg atgtaatagt 30120 gaaattacat tttttataaa tggatgaagc atattactct ggcaacttgg aatcagtact 30180 cggatacgtg tccgatatgc ataccgaact cgcatcaata tctcaattag ttattgccaa 30240 gatagaaact atagataatg atatattaaa caaggacatt gtaaatttta tcatgtgtag 30300 atcaaacttg gataatccat ttatctcttt cctagatact gtatatacta ttatagatca 30360 agagatctat cagaccgaat tgattaattc attagacgac aatgaaatta tcgattgtat 30420 agttaacaag tttatgagct tttataagga taacctagaa aatatagtag atgctatcat 30480 tactctaaaa tatataatga ataatccaga ttttaaaact acgtatgccg aagtactcgg 30540 ttccagaata gcggatatag atattaaaca agtgata cgt gagaatatac tacaattgtc 30600 taataatatc cgcgaacgat atttgtgaaa atattaaaaa aaaatacttt ttttattaaa 30660 tgacgtcgct tcgcgaattt agaaaattat gctgtgatat atatcacgca tcaggatata 30720 aagaaaaatc taaattaatt agagacttta taacagatag ggatgataaa tatttgatca 30780 ttaagctatt gcttcccgga ttagacgata gaatttataa catgaacgat aaacaaatta 30840 taaaattata tagtataata tttaaacaat ctcaggaaga tatgctacaa gatttaggat 30900 acggatatat aggagacact attaggactt tcttcaaaga gaacacagaa atccgtccac 30960 gagataaaag cattttaact ttagaagaag tggatagttt tttaactacg ttatcatccg 31020 taactaaaga atcgcatcaa ataaaattat tgactgatat cgcatccgtt tgtacatgta 31080 atgatttaaa atgtgtagtc atgcttattg ataaagatct aaaaattaaa gcgggccctc 31140 ggtacgtact taacgctatt agtcctcatg cctatgatgt gtttagaaaa tctaataact 31200 tgaaagagat aatagaaaat gcatctaaac aaaatctaga ctctatatct atttctgtta 31260 tgactccaat taatcccatg ttagcggaat cgtgtgattc tgtcaataag gcgtttaaaa 31320 aatttccatc aggaatgttt gcggaagtca aatacgatgg tgaaagagta caagttcata 31380 aaaataataa cgagtttgcc ttctttagta gaaacatgaa accagtactc tctcataaag 31440 tggattatct caaagaatac ataccgaaag catttaaaaa agctacgtct atcgtattgg 31500 attctgaaat tgttcttgta gacgaacata atgtaccgct cccgtttgga agtttaggta 31560 tacacaaaaa gaaagaatat aaaaactcta acatgtgttt gttcgtgttt gactgtttgt 31620 actttgatgg attcgatatg acggacattc cattgtacga acgaagatct tttctcaaag 31680 atgttatggt tgaaataccc aatagaatag tattctcaga gttgacgaat attagtaacg 31740 agtctcagtt aactgacgta ttggatgatg cactaacgag aaaattagaa ggattggtct 31800 taaaagatat taatggagta tacgaaccgg gaaagagaag atggttaaaa ataaagcgag 31860 actatttgaa cgagggttcc atggcagatt ctgccgattt agtagtacta ggtgcttact 31920 atggtaaagg agcaaagggt ggtatcatgg cagtctttct aatgggttgt tacgacgatg 31980 aatccggtaa atggaagacg gttaccaagt gttcaggaca cgatgataat acgttaaggg 32040 agttgcaaga ccaattaaag atgattaaaa ttaacaagga tcccaaaaaa attccagagt 32100 ggttagtagt taataaaatc tatattcccg attttgtagt agaggatcca aaacaatctc 32160 agatatggga aatttcagga gcagagttta catcttccaa gtcccatacc gcaaatggaa 32220 tatccattag atttcctaga tt tactagga taagagagga taaaacgtgg aaagaatcta 32280 ctcatctaaa cgatttagta aacttgacta aatcttaata gttacataca aattaaaata 32340 acactattta gttggtggtc gccatggatg gtgttattgt atactgtcta aacgcgttag 32400 taaaacatgg cgaggaaata aatcatataa aaaatgattt catgattaaa ccatgttgtg 32460 aaaaagtcaa gaacgttcac attggcggac aatctaaaaa caatacagtg attgcagatt 32520 tgccatatat ggataatgcg gtatccgatg tatgcaattc actgtataaa aagaatgtat 32580 caagaatatc cagatttgct aatttgataa agatagatga cgatgacaag actcctactg 32640 gtgtatataa ttattttaaa cctaaagatg ccattcctgt tattatatcc ataggaaagg 32700 atagagatgt ttgtgaacta ttaatctcat ctgataaagc gtgtgcgtgt atagagttaa 32760 attcatataa agtagccatt cttcccatgg atgtttcctt ttttaccaaa ggaaatgcat 32820 cattgattat tctcctgttt gatttctcta tcgatgcggc acctctctta agaagtgtaa 32880 ccgataataa tgttattata tctagacacc agcgtctaca tgacgagctt ccgagttcca 32940 attggttcaa gttttacata agtataaagt ccgactattg ttctatatta tatatggttg 33000 ttgatggatc tgtgatgcat gcaatagctg ataatagaac ttacgcaaat attagcaaaa 33060 atatattaga caata ctaca attaacgatg agtgtagatg ctgttatttt gaaccacaga 33120 ttaggattct tgatagagat gagatgctca atggatcatc gtgtgatatg aacagacatt 33180 gtattatgat gaatttacct gatgtaggcg aatttggatc tagtatgttg gggaaatatg 33240 aacctgacat gattaagatt gctctttcgg tggctggtat ttggaaagtt ttataggtag 33300 ttgatagaac aaaatacata attttgtaaa aataaatcac tttttatact aatatgacac 33360 gattaccaat acttttgtta ctaatatcat tagtatacgc tacacctttt cctcagacat 33420 ctaaaaaaat aggtgatgat gcaactttat catgtaatcg aaataataca aatgactacg 33480 ttgttatgag tgcttggtat aaggagccca attccattat tcttttagct gctaaaagcg 33540 acgtcttgta ttttgataat tataccaagg ataaaatatc ttacgactct ccatacgatg 33600 atctagttac aactatcaca attaaatcat tgactgctag agatgccggt acttatgtat 33660 gtgcattctt tatgacatcg cctacaaatg acactgataa agtagattat gaagaatact 33720 ccacagagtt gattgtaaat acagatagtg aatcgactat agacataata ctatctggat 33780 ctacacattc accggaaact agttctgaga aacctgatta tatagataat tctaattgct 33840 cgtcggtatt cgaaatcgcg actccggaac caattactga taatgtagaa gatcatacag 33900 acaccgtc ac atacactagt gatagcatta atacagtaag tgcatcatct ggagaatcca 33960 caacagacga gactccggaa ccaattactg ataaagaaga agatcataca gttacagaca 34020 ctgtctcata cactacagta agtacatcat ctggaattgt cactactaaa tcaaccaccg 34080 atgatgcgga tctttatgat acgtacaatg ataatgatac agtaccatca actactgtag 34140 gcggtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa atatttggta 34200 ttaccgcatt aattatattg tcggccgtgg caatattctg tattacatat tatatatata 34260 ataaacgttc acgtaaatac aaaacagaga acaaagtcta gatttttgac ttacataaat 34320 gtctgggata gtaaaatcta tcatattgag cgggccatct ggtttaggaa agacagccat 34380 agccaaaaga ctatgggaat atatttggat ttgtggtgtc ccataccact agatttcctc 34440 gtcctatgga acgagaaggt gtcgattacc attacgttaa cagagaggcc atctggaagg 34500 gaatagccgc cggaacatac tgagttttta ggaaatattt acggaacttc taaaactgct 34560 gtgaatacag cggctattaa taatcgtatt tgtgtgatgg atctaaacat cgacggtgtt 34620 agaagtttta aaaatactta cctaatgcct tactcggtgt atataagacc tacctctctt 34680 aaaatggttg agaccaagct tcgttgtaga aacactgaag cggatgatga gattcatcgt 34740 cgtgtgatgt tggcaaaaac tgacatggat gaggcaggtg aagccggtct attcgacact 34800 attatcattg aagatgatgt gaatttagca tatagtaagt taattcagat actacaggac 34860 cgtattagaa tgtattttaa cactaattag agacttaaga cttaaaactt gataattaat 34920 aatataactc gtttttatat gtggctattt caacgtctaa tgtattagtt aaatattaaa 34980 acttaccacg taaaacttaa aatttaaaat gatatttcat tgacagatag atcacacatt 35040 atgaactttc aaggacttgt gttaactgac aattgcaaaa atcaatgggt cgttggacca 35100 ttaataggaa aaggtggatt tggtagtatt tatactacta atgacaataa ttatgtagta 35160 aaaatagagc ccaaagctaa cggatcatta tttaccgaac aggcatttta tactagagta 35220 cttaaaccat ccgttatcga agaatggaaa aaatctcaca atataaagca cgtaggtctt 35280 atcacgtgca aggcatttgg tctatacaaa tccattaatg tggaatatcg attcttggta 35340 attaatagat taggtgcaga tctagatgcg gtgatcagag ccaataataa tagattacca 35400 aaaaggtcgg tgatgttgat cggaatcgaa atcttaaata ccatacaatt tatgcacgag 35460 caaggatatt ctcacggaga tattaaagcg agtaatatag tcttggatca aatagataag 35520 aataaattat atctagtgga ttacggattg gtttctaaat tcatgtctaa tggcgaaca t 35580 gttccattta taagaaatcc aaataaaatg gataacggta ctctagaatt tacacctata 35640 gattcgcata aaggatacgt tgtatctaga cgtggagatc tagaaacact tggatattgt 35700 atgattagat ggttgggagg tatcttgcca tggactaaga tatctgaaac aaagaattgt 35760 gcattagtaa gtgccacaaa acagaaatat gttaacaata ctgcgacttt gttaatgacc 35820 agtttgcaat atgcacctag agaattgctg caatatatta ccatggtaaa ctctttgaca 35880 tattttgagg aacccaatta cgacaagttt cggcacatat taatgcaggg tgtatattat 35940 taagtgtggt gtttggttga tgtaaaattt ttgtcgataa aaattaaaaa ataacttaat 36000 ttattattga tctcgtgtgt acaaccgaaa tcatggcgat gttttacgca cacgctctcg 36060 gtgggtacga cgagaatctt catgcctttc ctggaatatc atcgactgtt gccaatgatg 36120 tcagtttata ataacaagta tgacattgta aaagacaaat atatgtggtg ttacagtcag 36180 gtgaacaaga gatatattgg agcactgctg cctatgtttg agtgcaatga atatctacaa 36240 attggagatc cgatccatga tcaagaagga aatcacatat cgccacaaaa actactatgc 36300 tctaagcgga atcgggtacg agagtctaga cttgtgtttg gaaggagtag ggattcatca 36360 tcacgtactt gaaacagaaa acgctgtata tggaaaagtt caacatgatt a ttctactat 36420 caaagagaag gccaaagaaa tgaatgcact cagttcagga cctatcatcg attaccacgt 36480 ctggatagga gattgtatct gtcaagttac tgctgtggac gtacatggaa aggaaattat 36540 gagaatgaga ttcaaaaagg gtgcggtgct tccgatccca aatctggtaa aagttaaact 36600 tggggagaat gatacagaaa atctttcttc tactatatcg gcggcaccat cgaggtaacc 36660 acctctctgg aagacagtgt gaatcatgta ctcatgaaac gtttggaatc tatacgccat 36720 atgtggtctg ttgtatatga tcattttgat attgtgaatg gtaaagaatg ctgttatgtg 36780 catacgcatt tgtctaatca aaatcttata ccgagtactg taaaaacaaa tttgtacatg 36840 aagactatgg gatcatgcat tcaaatgagt atcttagcga actgaaggaa tcaggtggat 36900 ggagtcccag accagaaatg caggaatttg aatatccaga tggagtggaa gacactgaat 36960 caattgagag attggtagag gagttcttca atagatcaga acttcaggct ggtaaatcta 37020 ttaatgttaa acatacatct gtttcagcta agcaactaag aacacgtata ctctcatctt 37080 ttgccaacac agagggtgga tatttgttca ttggagttga taataataca cacaaagtat 37140 ttggattcac ggtgggttac gactacctca gactgataga gaatgatata gaaaagcata 37200 tcaaaagact ttgtgttgtg tatttctgtg agaagaaaga ggac atcaag tacacgtgtc 37260 gattcatcaa ggtatataaa cctggggatg aggctacctc gacatacgtg tgcgctatca 37320 aagtggaaag atgctgttgt gctgtgtttg cagattggcc agaatcatgg tatcaagaag 37380 tattctccag atgaataggt gtcacatata aaattttaat taatgtaact atagagaaca 37440 aataataggt tgtaatatca tatagacaat aactaacaat taattagtaa ctgttatctc 37500 tttttaacta actaactata cctattaata catcgtaatt atagttctta acatctatta 37560 atcattgatt cgcttcttta attttttata aaccaacatt gttaattgaa aagggataac 37620 atgttacaga atataaatta tatatggatt ttttttaaaa aggaaatact tgactggagt 37680 gtatatttat ctcttcatta tatagcacgc gtgttttcca atttttccac atcccatata 37740 atacaggatt ataatctcgt tcgaacatac gagaaagtgg ataaaacaat agttgatttt 37800 ttatctaggt tgccaaattt attccatatt ttagaatatg gggaaaatat tctacatatt 37860 tattctatgg atgatgctaa tacgaatatt ataatttttt ttctagatag agtattaaat 37920 attaataaga acgggtcatt tatacacaat ctcaggttat catcatccat taatataaaa 37980 gaatatgtat atcaattagt taataatgat catccagata ataggataag actaatgctt 38040 gaaaatggac gtagaacaag acattttttg tcctata tat cagatacagt taatatctat 38100 atatgtattt tatatagatg ccgaagacag ttacggttgt acattattac atagatgtat 38160 atatcactat aagaaatcag aatcagaatc agaatcatac aatgaattaa ttaagatatt 38220 gttaaataat ggatcagatg tagataaaaa agatacgtac ggaaacacac cttttatcct 38280 attatgtaaa cacgatatca acaacgtgga attgtttgag atatgtttag agaatgctaa 38340 tatagactct gtagacttta atagatatac acctcttcat tatgtctcat gtcgtaataa 38400 atatgatttt gtaaagttat taatttctaa aggagcaaat gttaatgcgc gtaataaatt 38460 cggaactact ccattttatt gtggaattat acacggtatc tcgcttataa aactatattt 38520 ggaatcagac acagagttag aaatagataa tgaacatata gttcgtcatt taataatttt 38580 tgatgctgtt gaatctttag attatctatt atccagagga gttattgata ttaactatcg 38640 tactatttac gacgctgtca gttataatgc gtataatacg ttggtctatc tattaaacag 38700 aaatggtgat tttgagacga ttactactag tggatgtaca tgtatttcgg aagcagtcgc 38760 aaacaacaac aaaataataa tggaagtact attgtctaaa cgaccatctt tgaaaattat 38820 gatacagtct atgatagcaa ttactaaaca taaacagcat aatgcagatt tattgaaaat 38880 gtgtataaaa tatactgcgt gtatgaccga ttatgatact cttatagatg tacaatcact 38940 acagcaatat aaatggtata ttttaagatg tttcgatgaa atagatatca tgaagagatg 39000 ttatataaaa aataaaactg tattccaatt agttttttgt atcaaagaca ttaatacttt 39060 aatgagatac ggtaaacatc cttctttcgt gaagtgcact agtctcgacg tatacggaag 39120 tcgtgtacgt aatatcatag catctattag atatcgtcag agattaatta gtctattatc 39180 caagaagctg gatcctggag ataaatggtc gtgttttcct aacgaaataa aatataacga 39240 taacgaactg tccacatatc taaaaatctt ataaacacta ttaaaatata aaatcacact 39300 acatcattgt ttccttttag tgctcgacag tgtatactat ttttaacgct cataaataaa 39360 aatgaaaacg atttccgttg ttacgttgtt atgcgtacta cctgctgttg tttattcaac 39420 atgtactgta cccactatga ataacgctaa attaacgtct accgaaacat cgtttaataa 39480 taaccagaaa gttacgttta catgtgatca gggatatcat tcttcggatc caaatgctgt 39540 ctgcgaaaca gataaatgga aatacgaaaa tccatgcaaa aaaatgtgca cagtttctga 39600 ttacatctct gaactatata ataaaccgct atacgaagtg aattccacca tgacactaag 39660 ttgcaacggc gaaacaaaat attttcgttg cgaagaaaaa aatggaaata cttcttggaa 39720 tgatactgtt acgtgtccta at gcggaatg tcaacctctt caattagaac acggatcgtg 39780 tcaaccagtt aaagaaaaat actcatttgg ggaatatata actatcaact gtgatgttgg 39840 atatgaggtt attggtgctt cgtacataag ttgtacagct aattcttgga atgttattcc 39900 atcatgtcaa caaaaatgtg atataccgtc tctatctaat ggattaattt ccggatctac 39960 attttctatc ggtggcgtta tacatcttag ttgtaaaagt ggttttatac taacgggatc 40020 tccatcatcc acatgtatcg acggtaaatg gaatcccata ctcccaacat gtgtacgatc 40080 taacgaaaaa tttgatccag tggatgatgg tcccgacgat gagacagatt tgagcaaact 40140 ctcgaaagac gttgtacaat atgaacaaga aatagaatcg ttagaagcaa cttatcatat 40200 aatcatagtg gcgttaacaa ttatgggcgt catattttta atctccgtta tagtattagt 40260 ttgttcctgt gacaaaaata atgaccaata taagttccat aaattgctac cgtgaatata 40320 aatccgttaa aataatgaat aattaataat taataattta ataacaaaca agtatcaaaa 40380 gattaaagac ttatagctag aatcaattga gatgtcttct tcagtggatg ttgatatcta 40440 cgatgccgtt agagcatttt tactcaggca ctattataac aagagattta ttgtgtatgg 40500 aagaagtaac gccatattac ataatatata caggctattt acaagatgcg ccgttatacc 40560 gttcgatgat atagt acgta ctatgccaaa tgaatcacgt gttaaacaat gggtgatgga 40620 tacacttaat ggtataatga tgaatgaacg cgatgtttct gtaagcgttg gcaccggaat 40680 actattcatg gaaatgtttt tcgattacaa taaaaatagt atcaacaatc aactaatgta 40740 tgatataatt aatagcgtat ctataattct agctaatgag agatatagaa gcgcttttaa 40800 cgacgatggt atatacatcc gtagaaatat gattaacaag ttgtacggat acgcatctct 40860 aactactatt ggcacgatcg ctggaggtgt ttgttattat ctgttgatgc atctagttag 40920 tttgtataaa taattatttc aatatactag ttaaaatttt aagattttaa atgtataaaa 40980 aactaataac gtttttattt gtaataggtg cattagcatc ctattcgaat aatgagtaca 41040 ctccgtttaa taaactgagt gtaaaactct atatagatgg agtagataat atagaaaatt 41100 catatactga tgataataat gaattggtgt taaattttaa agagtacaca atttctatta 41160 ttacagagtc atgcgacgtc ggatttgatt ccatagatat agatgttata aacgactata 41220 aaattattga tatgtctact attcaacgca gaggtcacac gtgtagaata tctaccaaat 41280 tatcatgcca ttatgataag tacccttata ttcacaaata tgatggtgat gagcgacaat 41340 attctattac tgcagaggga aaatgctata aaggaataaa atatgaaata agtatgatca 41400 acgatgatac tctattgaga aaacatactc ttaaaattgg atctacttat atatttgatc 41460 gtcatggaca tagtaataca tattattcaa aatatgattt ttaaaaattt aaaatatatt 41520 atcacttcag tgacagtagt caaataacaa acaacaccat gagatatatt ataattctcg 41580 cagttttgtt cattaatagt atacacgcta aaataactag ttataagttt gaatccgtc a 41640 attttgattc caaaattgaa tggactgggg atggtctata caatatatcc cttaaaaatt 41700 atggcatcaa gacgtggcaa acaatgtata caaatgtacc agaaggaaca tacgacatat 41760 ccgcatttcc aaagaatgat ttcgtatctt tctgggttaa atttgaacaa ggcgattata 41820 aagtggaaga gtattgtacg ggaccaccga ctgtaacatt aactgaatac gacgaccatc 41880 cgtatgctac tagaggtagc aaaaagattc ctatttacaa acgcggtgac atgtgtgata 41940 tctacttgtt gtatacggct aacttcacat tcggagattc taaagaacca gtaccatatg 42000 atatcgatga ctacgattgc acgtctacag gttgcagcat agactttgtc acaacagaaa 42060 aagtgtgcgt gacagcacag ggagccacag aagggtttct cgaaaaaatt actccatgga 42120 gttcgaaagt atgtctgaca cctaaaaaga gtgtatatac atgcgcaatt agatccaaag 42180 aagatgttcc caatttcaag gacaaaatgg ccagagttat caagagaaaa tttaactaaa 42240 tttctcggta gcacatcaaa tgatgttacc acttttctta gcatgcttaa cttgactaaa 42300 tattcataac taatttttat taatgataca aaaacgaaat aaaactgcat attatacact 42360 ggttaacgcc cttataggct ctaaccattt tcaagatgag gtccctgatt atagtccttc 42420 tgttcccctc tatcatctac tccatgtcta ttagacgatg tgagaagact g aagaggaaa 42480 catggggatt gaaaataggg ttgtgtataa ttgccaaaga tttctatccc gaaagaactg 42540 attgcagtgt tcatctccca actgcaagtg aaggcaatgg attcagggat atacgaaaca 42600 ccgataaatt ataaaaaaag caatgtgtcc gctgtttccg ttaataatac tattttcgta 42660 actggcggat tattcataaa taactctaat agcacgatcg tggttaacaa tatggaaaaa 42720 cttgacattt ataaagacaa acaatggtcg attatagaaa tgcctatggc tagggtatat 42780 cacggcatcg actcgacatt tggaatgtta tattttgccg gaggtctatc cgttaccgaa 42840 caatatggta atttagagaa aaacaacgag atatcttgtt acaatcctag aacgaataag 42900 tggtttgata tttcatatac tatttataag atatccatat catcattgtg taaactaaat 42960 aacgtcttct atgtatttag taaggacatt ggatatgtgg aaaagtatga tggtctcccc 43020 gctataaagg cattatcaac ttctccttat tgattgaaaa tgaaaatata aatagttttt 43080 atgtatagca gtattaccct atagttttat tgcttactac taacatggat acagatacag 43140 atgttacaaa tgtagaagat atcatgaatg aaatagatag agagaaagaa gaaatactaa 43200 aaaatgtaga aattgaaaat aataaaaaca ttaacaagaa tcatcccaat gaatatatta 43260 gagaagcact cgttattaat acaagtagta atagtgattc catt gataaa gaagttatag 43320 aatgtatcag tcacgatgta ggaatataga tcatatctac taatttttat aatcaataca 43380 aaacataaaa aacaactcgt tattacatag caggcatgga atccttcaag tattgttttg 43440 ataacgatgg caagaaatgg attatcggaa atactttata ttctggtaat tcaatactct 43500 ataaggtcag aaaaaatttc actagttcgt tctacaatta cgtaatgaag atagatcaca 43560 aatcacacaa gccattgttg tctgaaatac gattctatat atctgtattg gatcctttga 43620 ctatcgacaa ctggacacgg gaacgtggta taaagtattt ggctattcca gatctgtatg 43680 gaattggaga aaccgatgat tatatgttct tcgttataaa gaatttggga agagtattcg 43740 ccccaaagga tactgaatca gtcttcgaag catgcgtcac tatgataaac acgttagagt 43800 ttatacactc tcgaggattt acccatggaa aaatagaacc gaggaatata ctgattagaa 43860 ataaacgtct ttcactaatt gactattcta gaactaacaa actatacaag agtggaaact 43920 cacatataga ttacaacgag gacatgataa cttcaggaaa tatcaattat atgtgtgtag 43980 acaatcatct tggagcaaca gtttcaaaac gaggagattt agaaatgttg ggatattgca 44040 tgatagaatg gttcggtggc aaacttccat ggaaaaacga aagtagtata aaagtaataa 44100 aacaaaaaaa agaatataaa aaatttatag ctacttt ctt tgaggactgt tttcctgaag 44160 gaaatgaacc tctggaatta gttagatata tagaattagt atacacgtta gattattctc 44220 aaactcctaa ttatgacaga ctacgtagac tgtttataca agattgaaat attctttttt 44280 tatagagtgt ggtagtgtta cggatatcta atattaatat tagactatct ctatcgcgct 44340 acacgaccaa tatcgattac tatggatatc ttctatgaaa ggagagaatg tattcatttc 44400 tccagcgtca atctcgtcag tattgacaat actgtattat ggagctaatg gatccactgc 44460 tgaacagcta tcaaaatatg tagaaaagga ggagaacacg gataaggtta gcgctcagaa 44520 tatctcattc aaatccatga ataaagtata tgggcgatat tctgccgtgt ttaaagattc 44580 ctttttgaga aaaattggcg ataagtttca aactgttgac ttcactgatt gtcgcactat 44640 agatgcaatc aacaagtgtg tagatatctt tactgagggg aaaatcaatc cactattgga 44700 tgaacaattg tctcctagca attagtgccg tatactttaa agcaaaatgg ttgacgccat 44760 tcgaaaagga atttaccagt gattatccct tttacgtatc accaacggaa atggtagacg 44820 taagtatgat gtctatgtac ggcgagctat ttaatcacgc atctgtaaaa gaatcattcg 44880 gtaacttttc aatcatagaa ctgccatatg ttggagatac tagtatgatg gtcattcttc 44940 cagacaagat tgatggatta gaatccatag aacaaaatct aacagataca aattttaaga 45000 aatggtgtaa ctctctggaa gctacgttta tcgatgttca cattcccaag tttaaggtaa 45060 caggctcgta taatctggtg gatactctag taaagtcagg actgacagag gtgttcggtt 45120 caactggaga ttatagcaat atgtgtaatt tagatgtgag tgtcgacgct atgatccaca 45180 aaacgtatat agatgtcaat gaagagtata cagaagcagc tgcagcaact tgtgcactgg 45240 tgtcagactg tgcatcaaca attacaaatg agttctgtgt agatcatccg ttcatctatg 45300 tgattaggca tgttgatgga aaaatttttt tcgttggtag atattgctct ccgacaacta 45360 attgttaacc atttttttta aaaaaataga aaaaacatgt ggtattagtg caggtcgtta 45420 ttcttccaat tgcaattggt aagatgacgg ccaactttag tacccacgtc ttttcaccac 45480 agcactgtgg atgtgacaga ctgaccagta ttgatgacgt caaacaatgt ttgactgaat 45540 atatttattg gtcgtcctat gcataccgca acaggcaatg cgctggacaa ttgtattcca 45600 cactcctctc ttttagagat gatgcggaat tagtgttcat cgacattcgc gagctggtaa 45660 aaaatatgcc gtgggatgat gtcaaagatt gtgtagaaat catccgttgt tatataccgg 45720 atgagcaaaa aaccatcatc ggactttgtg catatgctgc tacttactgg ggaggtgaag 45780 accatcccac tagtaacagt ct gaacgcat tgtttgtgat gcttgagatg ctaaattacg 45840 tggattataa catcatattc cggcgtatga attgatgagt tgtacatctt gacattttct 45900 tctttcttct cttctccctt tcccagaaac aaactttttt tacccactat aaaataaaat 45960 gagtatacta cctgttatat ttctttctat atttttttat tcttcattcg ttcagacttt 46020 taacgcgcct gaatgtatcg acaaagggca atattttgca tcattcatgg agttagaaaa 46080 cgagccagta atcttaccat gtcctcaaat aaatacgcta tcatccggat ataatatatt 46140 agatatttta tgggaaaaac gaggagcgga taatgataga attataccga tagataatgg 46200 tagcaatatg ctaattctga acccgacaca atcagactct ggtatttata tatgcattac 46260 cacgaacgaa acctactgtg acatgatgtc gttaaatttg acaatcgtgt ctgtctcaga 46320 atcaaatata gatcttatct cgtatccaca aatagtaaat gagagatcta ctggcgaaat 46380 ggtatgtccc aatattaatg catttattgc tagtaacgta aacgcagata ttatatggag 46440 cgggcatcga cgccttagaa ataagagact taaacaacgg acacctggaa ttattaccat 46500 agaagatgtt agaaaaaatg atgctggtta ttatacatgt gttttagaat atatatacgg 46560 tggcaaaaca tataacgtaa ccagaattgt aaaattagag gtacgggata aaataatacc 46620 ttctactatg caatt accag aaggtgttgt aacttcaata ggtagtaatt tgactattgc 46680 gtgtagagta tcgttgagac ctcccacaac ggatgcagac gtcttttgga taagtaatgg 46740 tatgtattac gaagaagatg atggggacgg agacggtaga ataagtgtag caaataaaat 46800 ctatatgacc gataagagac gtgttattac atcccggtta aacattaatc ctgtcaagga 46860 agaagatgct acaacgttta cgtgtatggc gtttactatt cctagcatca gcaaaacagt 46920 tactgttagt ataacgtgaa tgtatgttgt tacatttcca tgtcaattga gtttataaga 46980 atttttatac attatcttcc aacaaacaat tgacgaacgt attgctatga ttaactccca 47040 cgatactatg catattatta atcattaact tgcagactat acctagtgct attttgacat 47100 actcatgttc ttgtgtaatt gcggtatcta tattattaaa gtacgtaaat ctagctatag 47160 ttttattatt taattttaga taatataccg tctccttatt tttaaaaatt gccacatcct 47220 ttattaaatc atgaatggga atttctatgt catcgttaat atattgtgaa caacaagagc 47280 agatatctat aggaaagggt ggaatgcgat acattgatct atgtagtttt aaaacacacg 47340 cgaactttga agaatttata taaatcattc catcgataca tccttctatg ttgacatgta 47400 tatatccagg aattctttta ttaatgtcag gaaatgtata aactaaaaca ttgcccgaaa 47460 gcggtgcc tc tatctgcgtt atatccgttc ttaacttaca aaatgtaacc aatacctttg 47520 catgacttgt tttgttcggc aacgttagtt taaacttgac gaatggatta attacaatag 47580 catgatccgc gcatctatta agttttttta ctttaacgcc cttgtatgtt tttacagaga 47640 ctttatctaa atttctagtg cttgtatgtg ttataaatat aacgggatat agaactgaat 47700 cacctacctt agatacccaa ttacatttta tcagatccag ataataaaca aattttgtcg 47760 ccctaactaa ttctatattg ttatatattt tacaattggt tatgatatca tgtaataact 47820 tggagtctaa cgcgcatcgt cgtacgttta tacaattgtg atttagtgta gtatatctac 47880 acatgtattt ttccgcacta tagtattctg gactagtgat aaaactatcg ttatatctgt 47940 cttcaatgaa ctcatcgaga tattgctctc tgtcatattc atacacctgc ataaactttc 48000 tagacatctt acaatccgtg ttattttagg atcatattta catatttacg ggtatatcaa 48060 agatgttaga ttagttaatg ggaatcgtct ataataatga atattaaaca attatatgag 48120 gacttttacc acaaagcatc ataaaaatga gtcgtcgtct gatttatgtt ttaaatatca 48180 accgcgaatc aactcataaa atacaagaga atgaaatata tacatatttt agtcattgca 48240 atatagacca tacttctaca gaacttgatt ttgtagttaa aaactatgat ctaaacagac 48300 gacaacctgt aactgggtat actgcactac actgctattt gtataataat tactttacaa 48360 acgatgtact gaagatatta ttaaatcatg gagtggatgt aacgatgaaa accagtagcg 48420 gacgtatgcc tgtttatata ttgcttacta gatgttgtaa tatttcacat gatgtagtga 48480 tagatatgat agacaaagat aaaaaccact tatcgcatag agactattcc aacctactac 48540 tagagtatat aaaatctcgt tacatgttat tgaaggaaga ggatatcgat gagaacatag 48600 tatccacttt attagataag ggaatcgatc ctaactttaa acaagacgga tatacagcgt 48660 tacattatta ttatttgtgt ctcgcacacg tttataaacc aggtgagtgt agaaaaccga 48720 taacgataaa aaaggccaag cgaattattt ctttgtttat acaacatgga gctaatctaa 48780 acgcgttaga taattgtggt aatacaccat tccatttgta tcttagtatt gaaatgtgta 48840 ataatattca tatgactaaa atgctgttga cttttaatcc gaatttcaaa atatgtaata 48900 atcatggatt aacgcctata ctatgttata taacttccga ctacatacaa cacgatattc 48960 ttgttatgtt aatacatcac tatgaaacaa atgttggaga aatgccgata gatgagcgtc 49020 gtataatcgt attcgagttt atcaaaacat attctacacg tccggcagat tcgataactt 49080 atttgatgaa taggtttaaa aatatagata tttatacccg ctatgaagga aagacatta t 49140 tacacgtagc atgtgaatat aataatacac acgtaataga ttatcttata cgtatcaacg 49200 gagatataaa tgcgttaacc gacaataaca aacacgctac acaactcatt atagataaca 49260 aagaaaattc cccatatacc attaattgtt tactgtatat acttagatat attgtagata 49320 agaatgtgat aagatcgttg gtggatcaac ttccatctct acctatcttc gatataaaat 49380 catttgagaa attcatatcc tactgtatac ttttagatga cacattttac aatagacacg 49440 ttaggaatcg caattctaaa acgtatcgat acgcattttc aaaatacatg tcgtttgata 49500 aatacgatgg tataataact aaatgtcata aagaaacaat attgctcaaa ctatccactg 49560 ttctagacac tacactatat gcagttttaa gatgccataa ttcgaaaaag ttaagaagat 49620 acctcaacga gttaaaaaaa tataataacg ataagtcctt taaaatatat tctaatatta 49680 tgaatgagag ataccttaat gtatattata aagatatgta cgtgtcaaag gtatatgata 49740 aactatttcc tgttttcaca gataaaaatt gtctactaac attactacct tcagaaatta 49800 tatacgaaat attatacatg ctgacaatta acgatcttta taatatatcg tatccaccta 49860 ccaaagtata gttgtatttt tctcatgcga tgtgtgtaaa aaaactgata ttatataaat 49920 attttagtgc cgtataatga agatgacgat gaaaatgatg gtacatatat a tttcgtatc 49980 attattgtta ttgctattcc acagttacgc catagacatc gaaaatgaaa tcacagaatt 50040 cttcaataaa atgagagata ctctaccagc taaagactct aaatggttga atccagcatg 50100 tatgttcgga ggcacaatga atgatatagc cgctctagga gagccattca gcgcaaagtg 50160 tcctcctatt gaagacagtc ttttatcgca cagatataaa gactatgtgg ttaaatggga 50220 gaggctagaa aaaaatagac ggcgacaggt ttctaataaa cgtgttaaac atggtgattt 50280 atggatagcc aactatacat ctaaattcag taaccgtagg tatttgtgta ccgtaactac 50340 aaagaatggt gactgtgttc agggtatagt tagatctcat attaaaaaac ctccttcatg 50400 cattccaaaa acatatgaac taggtactca tgataagtat ggcatagact tatactgtgg 50460 aattctttac gcaaaacatt ataataatat aacttggtat aaagataata aggaaattaa 50520 tatcgacgat attaagtatt cacaaacggg aaagaaatta attattcata atccagagtt 50580 agaagatagt ggaagataca actgttacgt tcattacgac gacgttagaa tcaagatgta 50640 aaatacttac ggttataccg tcgcaagacc acaggtttaa actaatacta gatccaaaaa 50700 tcaacgtaac gataggagaa cctgccaata taacatgcac tgctgtgtca acgtcattat 50760 tgattgacga tgtactgatt gaatgggaaa atccatccgg atgg cttata ggattcgatt 50820 ttgatgtata ctctgtttta actagtagag gcggtatcac cgaggcgacc ttgtactttg 50880 aaaatgttac tgaagaatat ataggtaata catataaatg tcgtggacac aactattatt 50940 ttgaaaaaac ccttacaact acagtagtat tggagtaaat acacaatgca tttttatata 51000 cattactgaa taattattat tattatttat atcgtatttg tgctataacg cgactatcta 51060 ggtatttgta tctcaccgat agagaacata taaatgtaga ctctattaaa cagttgtgta 51120 aaatatcaga tcctaataga tgtggatgta cggctttaga aatgagttca ttaaaatatg 51180 tgatatcaac ggaacatatt tatataatta tactattgct gttagtataa ttattgattc 51240 cacggaagaa ctaccaacag ttactccaat tacaacaaca tataattata ctatcgatga 51300 tagcactact gaagaactac aagtgactcc tcatatggat ctccatcgat gatacatgta 51360 ttaaaatact ttccgaataa gtcttttaaa tattgtatta attatgaaaa actatgctat 51420 gcgagtatga tacgatacta gattttatct ctagcgagag atgtcgttag aatcatttat 51480 caacgaatat cgataacatg tgtcatttat acgttaaagt ctgtccgtct tctctattgt 51540 ttagactgtt tgtagaatgc tgtgatataa acaaactagt agacacaaat atttaactca 51600 tgatgaagtt gagaatgata tgctttagct aatataa aaa tatattaatc cactatatat 51660 tctagacttg atttaaaacc gataaactac tactacgtac tgtataagtt aggagcagac 51720 cctaattatg tagatgatag aggtaatact tctgcatcta tatgtccact tatgagaaaa 51780 cgtcatttaa taagatgcat cgtgaaaaga aatttattaa agagttggta aaatatgaaa 51840 ccgaaagtaa ataatatagg aaatacacct ctacataact acgtatctca atatgatatc 51900 actctcattc ctcatccaca acccattaaa aaatggaaat taaagccctc tattagcata 51960 aacggctaca ggtctacctt tacaatggcc tttccttgtg cccagttcag accctgtcat 52020 tgccacgcta ctaaggactc cctgaatacc gtggccgacg tcagacattg tctgactgaa 52080 tacatcctgt gggtttctca tagatggacc catagagaaa gcgcagggtc tctctacagg 52140 cttctcatct ctttcagaac tgatgcaacg gagctctttg gtggtgagtt gaaggattca 52200 cttccgtgga gatcattaaa tgactccatg aaaaccgccg aagaacttcg tgcaatcatt 52260 ggactttgta ctcaatcagc tatcgtctct ggaagagtct tcaacgataa gtatatcgac 52320 atactactta tgctgcgaaa gattctgaac gagaacgact atctcaccct cttggatcat 52380 atccgcactg ctaaatacta aatctccttc atgctctctc actacacttt ttatcatctt 52440 atgaggaata attagcacca gaatagctat ggattgcaca tgtattctat gtcgtctact 52500 ggatgaagat gtgacgtaca aaaaaataaa actagaaatt gaaacgtgtc acaacttatc 52560 aaaacatata gatagacgag gaaacaatgc gctacattgt tacgtctcca ataaatgcga 52620 tacagacatt aagattgttc gactgttact ctctcgcgga gtcgagagac tttgtagaaa 52680 caacgaagga ttaactccgc taggagcata cagtaagcat agatacgtaa aatctcagat 52740 tgtgcatcta ctgatatcca gctattcgaa ttcctctaac gaactcaagt cgaatataaa 52800 tgatttcgac ttacgtctgc taaaatacct aattgtggat aaacggatac gtccgtccaa 52860 gaatacgaat tatgcaatca atggtctcgg attggtggat atatacgtaa cgacgcctaa 52920 tccgagacca gaagtattgc tatggcttct taaatcagaa tgttacagca ccggttacgt 52980 atttcgtacc tgtatgtaca acagtgatat gtgtaagaac tctcttcatt actatatatc 53040 gtctcataga gaatctctat ccaaggatgt aattaaatgt ttgatcgata acaatgtttc 53100 catccaatac tactggtctt gctcaaccat agatatagag attattaata aaggatgtgg 53160 acacgtgtag agtatacgac gtcagcccta tattagaggc gtattatcta aacaagcgat 53220 ttagagtaac cccatataat gtagacatgg aaatcgttaa tcttcttatt gagagacgtc 53280 atactcttgt cgacgtaatg cg tagtatta cttcgtacga ttccagagaa tataaccact 53340 acatcatcga taacattcta aagagattta gacaacagga tgaatccatc gtacaagcca 53400 tactgataaa ctacttacat tacggcgata tggtaagtat acctatcatt caatgcatgt 53460 tggataagac gacggacaac aactttgtta ataataatct cgtcgatgta aacgtcgtaa 53520 ggtttatcgt ggaaaatatg gacacgcggc tgtaaatcac atatctaaca atggccgtct 53580 atgtatgtac ggtctgatat tatcgagatt taataattgc gggtatcact gttatgaaga 53640 tgtatttgat atactaagca agtacatgga tgatatagat atgatcgata actctactat 53700 attacgcggt cgatgtcaat aatatacaat ttgcaaagcg gttattggaa tatggagcga 53760 gtgtcacgct cgataatcaa tacggccatc cagaaaagca gttaccaaag agaagctagt 53820 tgatttatta ctgagttacc atcccactct agagactatg attgacgcat ttaatagaga 53880 tatacgctat ctatatcctg aaccattatt cgcctgtatc agatacgcct taatcctaga 53940 tgatgatttt ccttctaaag taagtatgat atcgccggtc gtcataagga actaaagcgc 54000 tatagagcag acattaatag aatgaagaat gcctacatat caggcgtctc catgtttgat 54060 atattattta aacgaagcaa acgccacaga ttgagatacg caaagaacaa tgagaggatc 54120 gactccatta aataa tttat catggagtga taatgtcctg tttccatggc atattacaaa 54180 atcgattccg tccaagatga taaaaacatt taccggcatc ataaacacgg agtttatttt 54240 atatgtctcg cataaacatt actaaaaaaa tatattgttc ggttttcttt cacatcttta 54300 attatgaaaa agtaaatcat tatgagatgg acgcatcgtt cgcgacagta tgtggtacat 54360 acctaacgta tttatggacg acggtaagaa tgaaggtcac gtttctgtca acaatgtcga 54420 cgcgatcgtg taacacgact cacaatagaa tctgtgaatg ctctcccgat catggatgca 54480 aggcatgtgt ttcccaaaca aaatgtggaa taggatacgg agtatccgga gacgtcatct 54540 gttctccgtg tggtctcgga acatattctc acaccgtctc ttccgcagat aaatgcgaac 54600 ccgtacccag aaataccttt aactatatcg atgtggaaat taacctgtat ccagttaacg 54660 acacatcgtg tactcggacg accactaccg gtctcagcga atccatctca acgtcggaac 54720 taactattac tatgaatcat aaagactgcg atcccgtctt cttaataagg tagcgacttc 54780 aggtttcttt acaggagaaa ggtgtgcact ctgaatttcg agattaaatg caataacaaa 54840 gattcttcct ccaaacagtt aacgaaagca aagaatgata ctatcatgcc gcattcggag 54900 acagtaactc tagcgtcgac atctatatac tatatagtaa taccaatact caagactacg 54960 aaactgatac aatctcttat catgtgggta atgtagccat atgcccggta gttgcgatat 55020 acataaactg atcactaatt ccaaacccac ccgcttttta tagtaagttt ttcacccata 55080 aatacaataa ttaatttctc gtaaaagtag aaaatatatt ctaatttatt gcacggtaag 55140 gaagtagaat cataaagaac agtactcaat caatagcaat catgaaacaa tatatcgta c 55200 tggcatgcat gtgcctgcca gtcttcagca atcatcctca tcgtgtacgg aagaagaaaa 55260 caaacatcat atgggaatcg atgttattat caaagtcaca aagcaagacc aaacaccgac 55320 cgatgataag atttgccaat ccgtaacgga aattacagag tccgagtcag atccagatcc 55380 cgaggtggaa tcagtcgagg atgtagatcc tcctaccact tattactcca tcatcggtgg 55440 aggtctgaga atgaactttg gattcaccaa atgtcctcag attaaatcca tctcagaatc 55500 cgctgatgga aagactgtga ggtgtctatc gacatcagat gtagcgaaga agagaaagac 55560 agcgacatca agacccatcc agtactcggg tctaacatct ctcataagaa agtgagttac 55620 gaagatatca tcggttcaac gatcgtcgat acaaaatgtg tcaagaatct agagtttagc 55680 gttcgtatcg gagacatgtg caaggaatca tctgaacttg aggtcaagta tgtcgacgga 55740 tcggcatctg aaggtgcaac cgatgatact tcactcatcg attcaacaaa actcaaagcg 55800 tgtgtctgaa tcgataactc tattcatctg aaattggatg agtagggtta atcgaacgat 55860 tcaggcacac cacgaattaa aaaagtgtac cggacactat attccggttt gcaaaacaaa 55920 aagttacctc tcgcgacttc ttctttttct gtctcaatag tgtgatacga ttatgacact 55980 attcctattt cctttcaggg tatcacaaaa atattaaacc tctttctgat g gtctcatac 56040 aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaatatt tttattctct 56100 ttctctcttt gatggtctca taaaatattt ttattctctt tctctctttg atggtctcat 56160 aaaaaatatt tttattctct ttctctcttt gatggtctca taaaatattt ttattctctt 56220 tctctctttg atggtctcat aaaaaatatt tttattctct ttctctcttt gatggtctca 56280 taaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc tctttctctc 56340 ttcaatggag tcataaaata tttttattct ctttctctct tcgatggtct cacaaaaata 56400 ttaaacctct ttctgatggt gtcactaaaa tatttttatt ctctttctct cttcaatgga 56460 gtcataaaat atttttattc tctttctctc tttgatggtc tcacaaaaat atttttattc 56520 tctttctctc tttgatggtc tcacaaaaat atttttattc tctttctctc tttgatggtc 56580 tcacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 56640 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 56700 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 56760 tctctttctc tctttgatgg tctcataaaa aatattaaac ctctttctga tggtgtcact 56820 aaaatatttt tattctcatt ctctcttcaa tggagtcata aaat attttt attctctttc 56880 tctcttcgat ggtctcacaa aaatattaaa cctctttctg atggtgtcac taaaatattt 56940 ttattctcat tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga 57000 tggtctcaca aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca 57060 ttctctcttc aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat 57120 aaaaaaagtt ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa 57180 tattaaacct ctttctgatg gtgtcactaa aatattttta ttctctttct ctcttcaatg 57240 gagtcataaa atatttttat tctctttctc tcttcgatgg tctcacaaaa atattaaacc 57300 tctttctgat ggtgtcacta aaatattttt attctcattc tctcttcaat ggagtcataa 57360 aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 57420 tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 57480 ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 57540 ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 57600 ttgatggtct cataaaaaat attaaacctc tttctgatgg tgtcactaaa atatttttat 57660 tctcattctc tcttcaatgg agtcataaaa tattttt att ctctttctct cttcgatggt 57720 ctcacaaaaa tattaaacct ctttctgatg gtgtcactaa aatattttta ttctcattct 57780 ctcttcaatg gagtcataaa atatttttat tctctttctc tctttgatgg tctcataaaa 57840 aaagttttac aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 57900 ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 57960 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 58020 ttttattctc tttctctctt tgatggtctc acaaaaatat taaacctctt tctgatggag 58080 tcgtaaaaaa gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt 58140 ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt 58200 aaacctcttt ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca 58260 ctaaaatatt ttttattctc tttctgatgc atcaactatt tcttaaacaa taacgtccaa 58320 caacatatac tcgtcgagct tatcaacatc ccctatgccc atctaggtta ccagacaatt 58380 gtatatcata aaataatgtt tataattttt acaaaaatat ttttattctc tttctctctt 58440 tgatggtctc ataaaaaaag ttttacaaaa atatttttat tctctttctc tctttgatgg 58500 tctcataaaa aatattaaac ctctttctga tggtgtcact aaaatatttt tattctcatt 58560 ctctcttcaa tggagtcata aaatattttt attctctttc tctcttcgat ggtctcacaa 58620 aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctcat tctctcttca 58680 atggagtcat aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt 58740 tacaaaaata tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa 58800 aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 58860 tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 58920 ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 58980 ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 59040 ttgatggtct cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg 59100 gtctcataaa aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctctt 59160 tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga tggtctcaca 59220 aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca ttctctcttc 59280 aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 59340 ttacaaaaat atttttattc tc tttctctc tttgatggtc tcataaaaaa agttttacaa 59400 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 59460 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 59520 tctctttctc tctttgatgg tctcataaaa aaagttttac aaaaatattt ttattctctt 59580 tctctctttg atggtctcat aaaaaatatt aaacctcttt ctgatggtgt cactaaaata 59640 tttttattct ctttctctct tcaatggagt cataaaatat ttttattctc tttctctctt 59700 cgatggtctc acaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc 59760 tctttctctc ttcaatggag tcataaaata tttttattct ctttctctct ttgatggtct 59820 cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg gtctcataaa 59880 aaaagtttta caaaaatatt tttattctct ttctctcttt gatggtctca taaaaaaagt 59940 tttacaaaaa tatttttatt ctctttctct ctttgatggt ctcataaaaa aagttttaca 60000 aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt tacaaaaata 60060 tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa aatattttta 60120 ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt tttattctct 60180 ttctctcttt gatgg tctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60240 atttttattc tcattttctc tttctctctt caatggagtc ataaaatatt tttattctct 60300 ttctctcttt gatggtctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60360 atttttattc tcattctctc ttcaatggag tcataaaaaa gttttatctc tttctctctt 60420 cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc 60480 tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatgcat caactatttc 60540 ttaaacaata acgtccaaca acatatactc atcccctatg cccatctagg ttaccagaca 60600 attgtatatc ataaaataat gtttataatt tacacgttaa aatcatataa taaaacgtag 60660 atcgtataat attttttggt atataaatga tctagtaaaa tccatgtagg ggatactgct 60720 cacatttttt ctttggtaca aaatttcaca caagttttta tacagacaaa ttcttgtcca 60780 tatattttaa aacattgact tttgtactaa gaaaaatatc tagactaact atctctttct 60840 ctttctctct tcgatggtct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 60900 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 60960 ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 61020 agttttat ct ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag 61080 tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat taaacctctt 61140 tctgatggtg tcactaaaat atttttattc tctttctctc ttcgatggtc tcacaaaaat 61200 attaaacctc tttctgatgg agtcgtaaaa aagttttatc tctttctcct tcgatggtct 61260 cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 61320 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 61380 ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa 61440 gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt ctgatggagt 61500 cgtaaaaaag ttttatctct ttctccttcg atggtctcac aaaaatatta aacctctttc 61560 tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac aaaaatatta 61620 aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac 61680 aaaaatatta aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctccttcga 61740 tggtctcaca aaaatattaa acctctttct gatagtctct ataaagcgat tgatttttct 61800 taccctctag agtttcctac ggtcgttggt cacacatttt tttctagaca ctaaataaat 61860 agtaagatta aattaattat aaaattatgt atataatatt aattataaaa ttatgtatat 61920 gatttactaa ctttagttag ataaattaat aatacataaa ttttagtata ttaatattat 61980 aaattataataa tacataaatt ttagtatat aatattatat tattagatgt gg cctattaga <210> 16
<211> 66679
<212> DNA
<213> Artificial Sequence
<220>
<223>
Claims (42)
하나 이상의 DNA 단편을 숙주 세포로 형질감염시키며, 여기서 하나 이상의 DNA 단편은 폭스바이러스가 숙주 세포에서 재구성되도록 목적하는 폭스바이러스의 전체 게놈 DNA 서열을 포함하는 것인 단계.A method for producing a poxvirus vector or a recombinant poxvirus vector comprising the steps of:
transfecting the one or more DNA fragments into a host cell, wherein the one or more DNA fragments comprise the entire genomic DNA sequence of a poxvirus for which the poxvirus is desired to be reconstituted in the host cell.
(i) 목적하는 폭스바이러스의 전체 게놈을 포함하는 단일 DNA 단편, 또는 2개 이상의 DNA 단편이, 공동-형질감염 시 숙주 세포에서 발현될 때, 순차적으로 조립되어 폭스바이러스 게놈의 전장 서열을 포함하고 목적하는 재조합 폭스바이러스의 재구성을 가능하게 하도록 목적하는 폭스바이러스의 게놈의 부분적인 서열을 각각 포함하는 2개 이상의 DNA 단편, 및
(ii) 폭스바이러스의 하나 이상의 삽입 부위에 삽입된 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열 또는 다른 이종성 DNA 서열로서, 여기서 항원 또는 그의 서브유닛 또는 다른 이종성 DNA 서열은 하나 이상의 폭스바이러스 DNA 단편의 형질감염 및 폭스바이러스의 재구성 시 숙주 세포에서 발현되는 것인 DNA 서열.An expression system comprising:
(i) a single DNA fragment comprising the entire genome of the poxvirus of interest, or two or more DNA fragments, when expressed in a host cell upon co-transfection, assemble sequentially to contain the full-length sequence of the poxvirus genome; two or more DNA fragments each comprising a partial sequence of the genome of the desired poxvirus to enable reconstitution of the desired recombinant poxvirus, and
(ii) one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof inserted into one or more insertion sites of a poxvirus, wherein the antigen or subunits thereof or other heterologous DNA sequences comprise one or more A DNA sequence expressed in a host cell upon transfection of the poxvirus DNA fragment and reconstitution of the poxvirus.
(i) 목적하는 폭스바이러스의 전체 게놈을 포함하는 단일 DNA 단편, 또는 2개 이상의 DNA 단편이, 공동-형질감염 시 숙주 세포로 전달될 때, 순차적으로 조립되어 폭스바이러스 게놈의 전장 서열을 포함하도록 목적하는 폭스바이러스의 게놈의 부분적인 서열을 각각 포함하는 2개 이상의 DNA 단편, 및
(ii) 폭스바이러스의 하나 이상의 삽입 부위에 삽입된 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열 또는 다른 이종성 DNA 서열로서, 여기서 항원, 그의 서브유닛 또는 단편 또는 다른 이종성 DNA 서열은 하나 이상의 폭스바이러스 DNA 단편의 형질감염 시 숙주 세포에서 발현되는 것인 DNA 서열.A vaccine composition for preventing or treating cancer or viral infection, comprising:
(i) a single DNA fragment comprising the entire genome of the poxvirus of interest, or two or more DNA fragments, when delivered to a host cell upon co-transfection, assemble sequentially to contain the full-length sequence of the poxvirus genome; two or more DNA fragments each comprising a partial sequence of the genome of the poxvirus of interest, and
(ii) one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof inserted into one or more insertion sites of a poxvirus, wherein the antigen, subunits or fragments thereof or other heterologous DNA sequences are A DNA sequence that is expressed in a host cell upon transfection of one or more poxvirus DNA fragments.
(i) 목적하는 폭스바이러스의 전체 게놈을 포함하는 단일 DNA 단편, 또는 2개 이상의 DNA 단편이, 공동-형질감염 시 숙주 세포로 전달될 때, 순차적으로 조립되어 폭스바이러스 게놈의 전장 서열을 포함하도록 목적하는 폭스바이러스의 게놈의 부분적인 서열을 각각 포함하는 2개 이상의 DNA 단편, 및
(ii) 폭스바이러스의 하나 이상의 삽입 부위에 삽입된 하나 이상의 항원, 그의 서브유닛 또는 단편을 코딩하는 하나 이상의 DNA 서열 또는 다른 이종성 DNA 서열로서, 여기서 항원, 그의 서브유닛 또는 단편 또는 다른 이종성 DNA 서열은 하나 이상의 폭스바이러스 DNA 단편의 형질감염 시 숙주 세포에서 발현되는 것인 DNA 서열.A method of preventing or treating cancer or a viral infection in a subject comprising administering to the subject a prophylactically or therapeutically effective amount of a vaccine composition, wherein the vaccine comprises:
(i) a single DNA fragment comprising the entire genome of the poxvirus of interest, or two or more DNA fragments, when delivered to a host cell upon co-transfection, assemble sequentially to contain the full-length sequence of the poxvirus genome; two or more DNA fragments each comprising a partial sequence of the genome of the poxvirus of interest, and
(ii) one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof inserted into one or more insertion sites of a poxvirus, wherein the antigen, subunits or fragments thereof or other heterologous DNA sequences are A DNA sequence that is expressed in a host cell upon transfection of one or more poxvirus DNA fragments.
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US202062969628P | 2020-02-03 | 2020-02-03 | |
US62/969,628 | 2020-02-03 | ||
US202063113803P | 2020-11-13 | 2020-11-13 | |
US63/113,803 | 2020-11-13 | ||
PCT/US2021/016247 WO2021158565A2 (en) | 2020-02-03 | 2021-02-02 | Poxvirus-based vectors produced by natural or synthetic dna and uses thereof |
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KR20220148823A true KR20220148823A (en) | 2022-11-07 |
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CN (1) | CN115397998A (en) |
AU (1) | AU2021217073A1 (en) |
BR (1) | BR112022014738A2 (en) |
CA (1) | CA3168836A1 (en) |
IL (1) | IL294926A (en) |
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CN115433741A (en) * | 2022-06-23 | 2022-12-06 | 广西大学 | Construction method of recombinant virus taking Gatas virus as vector to express reporter protein |
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- 2021-02-02 JP JP2022547055A patent/JP2023512294A/en active Pending
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WO2021158565A3 (en) | 2021-09-16 |
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MX2022009200A (en) | 2023-01-04 |
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