CA3168836A1 - Poxvirus-based vectors produced by natural or synthetic dna and uses thereof - Google Patents

Abstract

Disclosed are methods of producing poxvirus-based vectors or recombinant poxvirus-based vectors from naturally derived, chemically synthesized DNA fragments, or a combination of naturally derived and chemically synthesized DNA fragments. One or more DNA sequences encoding one or more antigens, subunits or fragments thereof or other heterologous gene sequences are inserted in one or more poxvirus insertion sites in one or more DNA fragments. The methods include transfecting a host cell with one or more circular or linear DNA fragments such that a poxvirus or recombinant poxvirus is reconstituted in the host cell, the reconstituted poxvirus or recombinant poxvirus comprising the genome of a desired poxvirus. Also disclosed are poxviruses or recombinant poxviruses produced by the technology and uses thereof.

Description

DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

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VOLUME

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PDXVIRUS-BASED VECTORS PRODUCED BY NATURAL OR
SYNTHETIC DNA AND USES THEREOF
PRIORITY CLAIM
[0001] This application claims priority to United States Provisional Patent Application No. 62/969,628, filed February 3, 2020, and United States Provisional Patent Application No. 63/113,803, filed November 13, 2020, the contents of which are hereby incorporated by reference in their entirety.
SEQUENCE LISTING

[0002] The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on February 2, 2021, is named 8200W000_SequenceListing.txt and is 652 kilobytes in size.
BACKGROUND

[0003]
Poxviruses are large double-stranded, enveloped DNA viruses that replicate entirely in the cytoplasm of infected cells by encoding their own enzymes for DNA transcription and replication20,27. One of the greatest achievements in medical history was the eradication of the causative agent of smallpox (Variola virus) by mass vaccination with replication-competent, attenuated Vaccinia virus vaccine strains. Vaccinia virus is used as the prototype member to study poxvirus replication and has been further developed to generate recombinant vaccines and oncolytic agents.

[0004] Modified Vaccinia Ankara (MVA) is a highly attenuated orthopoxvirus that was derived from its parental strain Chorioallantois Vaccinia Ankara (CVA) by 570 passages on chicken embryo fibroblasts (CEF)1. As a result of the attenuation process MVA has acquired six major genome deletions (De11-6) as well as multiple shorter deletions, insertions, and point mutations, leading to gene fragmentation, truncation, short internal deletions, and amino acid substitutions2. While all of these mutations are likely to contribute to the highly-attenuated phenotype of MVA, the precise genetic determinants that are associated with the MVA assembly deficiency remain obscure23. MVA has severely restricted host cell tropism, allowing productive assembly only in avian cells, e.g. CEF and baby hamster kidney (BHK)

5 cells, whereas in human and most other mammalian cells, MVA assembly is abortive due to a late block in virus assembly4,8. Although non-pathogenic and highly attenuated, MVA maintains excellent immunogenicity as demonstrated in various animal models and humans8,7. In the late phase of the smallpox eradication campaign, MVA was used as a priming vector for the replication competent vaccinia-based vaccine in over 120,000 individuals in Germany and no adverse events were reported8. In the past decades, MVA has been developed as a stand-alone smallpox vaccine and is currently pursued by the United States (US) government as a safer alternative to substitute the existing vaccinia-based vaccine stocks as a preventative countermeasure in case of a smallpox 0utbreak8-11. The FDA approved MVA, under the trade name Jynneos (Bavarian Nordic) on September 24, 2019 to prevent both smallpox and monkey pox. Previously, the identical MVA vaccine using the trade name lmvamune was approved in Europe as a smallpox vaccine.
[0005] All currently used MVA vectors or derivatives thereof are licensed or owned by academic, commercial, or governmental entities, which greatly restricts their use to develop MVA-based vaccine vectors. Therefore, there is a need to develop alternative MVA vectors for various research, prophylactic, and therapeutic uses. In addition, novel technologies are urgently needed to accelerate the development of recombinant poxvirus vectors for pathogen preparedness and disease prevention.
SUMMARY

[0006] In one aspect, this disclosure relates to a method of producing a poxvirus vector or a recombinant poxvirus vector. The method entails the steps of transfecting one or more DNA fragments into a host cell, wherein the one or more DNA fragments comprise the entire genomic DNA sequence of a desired poxvirus, such that the poxvirus is reconstituted in the host cell. In certain embodiments, two or more DNA fragments are co-transfected into the host cell, each DNA fragment comprises a partial sequence of the poxvirus genome such that the two or more DNA fragments are assembled sequentially by homologous recombination and comprise the full-length sequence of the poxvirus genome when reconstituted in the host cell. In certain embodiments, the method further entails infecting the host cell with a helper virus before, during, or after the transfection of the one or more DNA
fragments to initiate the transcription of the one or more DNA fragments. In certain embodiments, the helper virus is Fowl pox virus (FPV), sheep fibroma virus, vaccinia virus, or cowpox virus. In certain embodiments, the one or more DNA fragments are circularized before transfection or transfected in circular forms into the host cell. In certain embodiments, the one or more DNA fragments are cloned into a plasmid or a bacterial artificial chromosome (BAC) vector. In certain embodiments, the one or more DNA fragments are linearized before co-transfection or transfected in linearized forms into the host cell. In certain embodiments, the one or more DNA
fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments. In certain embodiments, the poxvirus genomic sequence comprises the sequence of Modified Vaccinia Ankara (MVA) Accession No. #U94848 or #AY603355. In certain embodiments, the poxvirus genomic sequence comprises the sequence of Vaccinia virus genome. In certain embodiments, two adjacent DNA fragments have an overlapping sequence to facilitate homologous recombination. In certain embodiments, the overlapping sequence is between about 100 bp and about 5000 bp in length. In certain embodiments, the one or more DNA fragments further comprise an inverted terminal repeat (ITR) region. In certain embodiments, the one or more DNA fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genome resolution (CR) sequence, or both, wherein the HL
or the CR sequence is added to one or both ends of the DNA fragment as single stranded or double stranded DNA sequences in sense or antisense orientation.
In certain embodiments, the one or more DNA fragments further comprise one or more HL sequences and one or more CR sequences. In certain embodiments, each HL
sequence is flanked by two CR sequences at both ends of the HL sequence. In certain embodiments, wherein only a subset of the one or more DNA fragments comprise the HL or CR sequence. In certain embodiments, the one or more DNA
fragments further comprise one or more DNA sequences encoding one or more antigens, subunits, or fragments thereof or other heterologous DNA sequences.
In certain embodiments, two or more DNA fragments comprise the DNA sequence of the same antigen, a subunit or fragment thereof or the same heterologous DNA
sequence. In certain embodiments, two or more DNA fragments comprise the DNA
sequences of different antigens, subunits, or fragments thereof or other heterologous DNA sequences. In certain embodiments, the DNA sequences of the antigens, subunits, or fragments thereof or other heterologous DNA sequences are codon optimized for expression in the host cell. In certain embodiments, the one or more DNA fragments further comprise a virus promoter upstream of the DNA sequences of the antigens, subunits, or fragments thereof or other heterologous DNA
sequences, a transcription termination signal downstream the DNA sequences of the antigens, subunits, or fragments thereof or other heterologous DNA sequences, or both. In certain embodiments, the DNA sequences encoding the antigens, subunits, or fragments thereof or other heterologous DNA sequences are inserted in one or more poxvirus insertion sites such as intergenic regions, non-essential genes and regions, and deletion sites.

[0007] In another aspect, disclosed herein is an expression system comprising:
(i) a single DNA fragment comprising the entire genome of a desired poxvirus, or two or more DNA fragments each comprising a partial sequence of the genome of the desired poxvirus such that the two or more DNA fragments, when transferred into the host cell upon co-transfection, are assembled sequentially and comprise the full-length sequence of the poxvirus genome and enable reconstitution of the poxvirus, and (ii) one or more DNA sequences encoding one or more antigens, subunits, or fragments thereof or other heterologous DNA sequences inserted in one or more insertion sites of the poxvirus, wherein the antigens or subunits thereof or other heterologous DNA sequences are expressed in the host cell upon transfection of the one or more poxvirus DNA fragments and reconstitution of the poxvirus. In certain embodiments, the one or more DNA fragments are circularized before transfection or transfected in circular forms into the host cell. In certain embodiments, the one or more DNA fragments are cloned into a plasmid or a BAC vector. In certain embodiments, the one or more DNA fragments are linearized before transfection or transfected in linearized forms into the host cell. In certain embodiments, the one or more DNA fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments. In certain embodiments, the genomic sequence of the poxvirus comprises the sequence of MVA Accession No. #U94848 or #AY603355. In certain embodiments, the two adjacent DNA fragments have an overlapping sequence to facilitate homologous recombination. In certain embodiments, the overlapping sequence is between about 100 bp and about 5000 bp in length. In certain embodiments, the one or more DNA
fragments further comprise an inverted terminal repeat (ITR) region. In certain embodiments, the one or more DNA fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genome resolution (CR) sequence, or both, wherein the HL or the CR sequence is added to one or both ends of the DNA
fragment as single stranded or double stranded DNA sequences in sense or antisense orientation. In certain embodiments, the one or more DNA fragments further comprise one or more HL sequences and one or more CR sequences. In certain embodiments, each HL sequence is flanked by two CR sequences at both ends of the HL sequence. In certain embodiments, only a subset of the one or more DNA fragments comprises the HL or CR sequence. In certain embodiments, the one or more DNA fragments further comprise a virus promoter upstream of the DNA
sequences encoding the antigens, subunits or fragments thereof or other heterologous DNA sequences, a transcription termination signal downstream of the DNA sequences encoding the antigens, subunits or fragments thereof or other heterologous DNA sequences, or both. In certain embodiments, the DNA
sequences encoding one or more antigens, subunits or fragments thereof or other heterologous DNA sequences are inserted in one or more poxvirus insertion sites.

[0008] In another aspect, disclosed herein is a vaccine composition for preventing or treating cancer or an infectious disease comprising: (i) a single DNA
fragment comprising the entire genome of a desired poxvirus, or two or more DNA
fragments each comprising a partial sequence of the genome of the desired poxvirus such that the two or more DNA fragments, when transferred into the host cell upon co-transfection, are assembled sequentially and comprise the full-length sequence of the poxvirus genome and enable reconstitution of the poxvirus, and (ii) one or more DNA sequences encoding one or more antigens, subunits, or fragments thereof or other heterologous DNA sequences inserted in one or more insertion sites of the poxvirus, wherein the antigens, subunits or fragments thereof or other heterologous DNA sequences are expressed in the host cell upon transfection of the one or more DNA fragments and reconstitution of the poxvirus. In certain embodiments, the antigens, subunits or fragments thereof or other heterologous DNA sequences are inserted in one or more poxvirus insertion sites. In certain embodiments, the vaccine composition further comprises a pharmaceutically acceptable carrier, adjuvant, additive or combination thereof.

[0009] In yet another aspect, disclosed herein is a method of preventing or treating cancer or a viral infection in a subject comprising administering a prophylactically or therapeutically effective amount of a vaccine composition to the subject, wherein the vaccine comprises: (i) a single DNA fragment comprising the entire genome of a desired poxvirus, or two or more DNA fragments each comprising a partial sequence of the genome of the desired poxvirus such that the two or more DNA fragments, when transferred into the host cell upon co-transfection, are assembled sequentially and comprise the full-length sequence of the poxvirus genome and enable reconstitution of the poxvirus, and (ii) one or more DNA
sequences encoding one or more antigens, subunits or fragments thereof or other heterologous DNA sequences inserted in one or more insertion sites of the poxvirus, wherein the antigens, subunits, or fragments thereof or other heterologous DNA

sequences are expressed in the host cell upon transfection of the one or more DNA
fragments and reconstitution of the poxvirus. In certain embodiments, the antigens, subunits, or fragments thereof or other heterologous DNA sequences are inserted in one or more poxvirus insertion sites.
BRIEF DESCRIPTION OF THE DRAWINGS

[0010] This application contains at least one drawing executed in color.
Copies of this application with color drawing(s) will be provided by the Office upon request and payment of the necessary fees.

[0011] Figures 1A-1C show the design of the sMVA construction. Figure 1A:
Schematic of MVA genome. The MVA genome is approximately 178 kbp in length and contains an internal unique region (UR) flanked by large -9.6 kbp long inverted terminal repeats (ITRs). Figure 1B: Schematic of sMVA fragments. Each of the three sMVA fragments is approximately 60 kbp in length. sMVA fragment 1 (F1) contains the sequence of the left part of the MVA genome, including the left ITR, sMVA fragment 2 (F2) contains the sequence of the middle part of the MVA
genome, and sMVA fragment 3 (F3) contains the sequence of the right part of the MVA
genome, including the right ITR. sMVA F1 and F2 as well as sMVA F2 and F3 share -3 kbp overlapping sequences for homologous recombination (dotted crossed lines).
Indicated are the approximate positions of commonly used MVA insertion sites, including DeI2, IGR44/45 (44/45), and IGR64/65 (69/70) within sMVA F1, (69/70) and the TK insertion site within sMVA F2, and Del3 within sMVA F3.
Figure 1C: Schematic of the terminal HL and OR sequences. Each of the sMVA fragments contains at both ends a sequence composition comprising a duplex copy of the MVA
terminal HL and flanking OR sequences to promote genome resolution and packaging. Sfil and Fsel restriction sites are included as indicated at both ends of each of the sMVA fragments to release the fragments from the bacterial vector backbone (pCCI-Brick) with or without the terminal OR/HL/OR sequences by enzymatic digestion.

[0012] Figure 2 shows reconstitution of sMVA. A
schematic for the generation of sMVA (sMVA) using the three sMVA fragments (F1-F3) as shown in Figure 1 is depicted. The three sMVA fragments are stably maintained in E.
coil, then isolated from the bacteria and transferred by transfection as circular or linearized DNA molecules into MVA permissive BHK or CEF cells. The transfected cells are subsequently infected with Fowl pox virus (FPV) as a helper virus to initiate MVA genome transcription and replication and consequently the reconstitution of the viral form of sMVA.

[0013] Figure 3 depicts the construction of recombinant sMVA with one antigen. A schematic is shown for an example of the construction of recombinant sMVA (rsMVA) with one introduced antigen sequence, heterologous gene sequence, or other genome alteration. The antigen or heterologous gene sequence (black circle) is inserted into the MVA genome sequence of F2 (or one of the other sMVA
fragments (F1 or F3)) by bacterial recombination methods in E. coil using linear FOR-derived products or other forms of linear DNA constructs. The modified sMVA
fragment F1 and the unmodified sMVA fragments F2 and F3 are isolated from E.
coil and co-transfected as circular or linearized forms into FPV-infected BHK or CEF
cells to initiate the reconstitution of rsMVA expressing one antigen or heterologous gene sequence. Nucl. = cell nucleus.

[0014] Figure 4 illustrates the construction of recombinant sMVA with three antigens. A schematic is shown for an example of the generation of a recombinant sMVA (rsMVA) with 3 introduced antigen sequences, heterologous gene sequences, or other genome alterations. An antigen or heterologous gene sequence (shown in square, circle, or rectangle) is inserted into each of the three sMVA
fragments (F1-F3) by bacterial recombination techniques in E. coil using linear FOR-derived products or other forms of linear DNA constructs. The modified F1, F2, and F3 sMVA fragments are isolated from E. coil and co-transfected in circular or linearized forms into permissive BHK or CEF cells, where rsMVA virus expressing three antigen or heterologous gene sequences are reconstituted in the presence of FPV
as a helper virus. Nucl. = cell nucleus.

[0015] Figure 5 illustrates the sMVA reconstitution process. A schematic is shown for an example of the tissue culture reconstitution process of sMVA or rsMVA
using the three sMVA fragments (F1-F3) or modified forms thereof. BHK cells seeded in 6-well tissue culture format are co-transfected with the three sMVA
fragments (unmodified, modified, or a combination thereof) and subsequently infected with FPV as a helper virus to initiate the transcription and replication of the sMVA fragments and, consequently, the reconstitution of sMVA virus. The transfected/infected BHK cells are transferred every other day (at 2, 4, and 6 days post transfection/infection (dpt/i)) into larger tissue culture formats as indicated to promote sMVA reconstitution. Plaque development and progression can be detected after the day 2 and day 4 cell transfers, resulting in 90-100%
infected BHK
cells at 7 or 8 dpt/i after the day 6 transfer.

[0016] Figures 6A-6B show sMVA infectivity analysis. Figure 6A is a plaque analysis showing representative bright field microscopy images of 5 individual plaques in BHK cell monolayers infected with sMVA or MVA NIH clone 1 at 1 day post infection (dpi). Figure 6B shows the progression of infection. Shown are representative bright field microscopy images of BHK cell monolayers infected with sMVA or MVA NIH clone 1 at 1, 2, and 3 dpi. Mock-infected (uninfected) BHK
cell monolayers were analyzed as control. Plaques and infected areas were visualized by immunostaining for the Vaccinia virus B5R protein.

[0017] Figures 7A-7L show FOR analysis of the reconstituted sMVA. BHK
cells were infected at MOI 5 with sMVA virus reconstituted from the three sMVA

fragments (F1-F3) or MVA NIH clone 1 and DNA extracted from infected BHK cells was evaluated by FOR. DNA extracted from mock-infected (uninfected) BHK cells (BHK) as well as H20 only (Ctrl) was analyzed for control. The FOR analysis included sequence detection of the inverted terminal repeats (ITR) (Figure 7A), the transition from the left ITR into the internal unique region (LITR/UR) (Figure 7B) and the MVA Deletion 2 site (De12) (Figure 7C) located in sMVA Fl-derived DNA; the intergenic region (IGR) between MVA 69R and 70L (IGR69/70) (Figure 7D) located in sMVA F2-derived DNA; the MVA Deletion 3 site (De13) (Figure 7E) and the transition from the internal UR into the right ITR (UR/RITR) (Figure 7F) located in sMVA F3-derived DNA; the reconstitution of the recombination site of sMVA F1 and F2 (F1/F2) (Figure 7G) as well as of F2 and F3 (F2/F3) (Figure 7H), and the MVA
genome positions containing the five nucleotide polymorphism (Polym. 1, 2, 3, 4/5) (Figures 7I-7L) specific for MVA strain Antoine. The expected FOR products are indicated by the arrows at the right side of each panel. The expected sizes of the FOR products are given in the brackets below each panel.

[0018] Figure 8 shows reconstitution of sMVA with a single fluorescence marker. Shown are representative immunofluorescence and bright field microscopy images of BHK cell monolayers at 6 and 7 days post transfection/infection (dpt/i) using unmodified sMVA fragments F1 and F3 and modified sMVA fragment F2 with inserted red fluorescence protein (RFP) marker (F2-RFP). The sMVA
reconstitution procedure from these fragments is illustrated in Figure 5 and FPV was used as a helper virus. Mock-transfected/infected BHK cell monolayers were analyzed as control.

[0019] Figure 9 shows reconstitution of sMVA with double fluorescence markers. Shown are representative immunofluorescence and bright field microscopy images of BHK cell monolayers at 6 and 7 days post transfection/infection (dpt/i) using unmodified sMVA fragment F1, modified sMVA fragment F2 with inserted red fluorescence protein (RFP) marker (F2-RFP), and modified sMVA fragment F3 with inserted blue fluorescence protein (BFP) marker (F3-BFP). The sMVA
reconstitution procedure from these fragments is illustrated in Figure 5 and FPV was used as a helper virus. Mock-transfected/infected BHK cell monolayers were analyzed as control.

[0020] Figures 10A-10H illustrate various examples of rsMVA HCMV vector construction. Shown are examples for the use of the sMVA fragments F1-F3 to generate rsMVA vectors with inserted HCMV antigen sequences based on the five subunits of the pentamer complex (PC; including UL128, UL130, UL131A, gH, and gL), glycoprotein B (gB), phosphoprotein 65 (pp65), and/or the immediately-early proteins 1 and 2 (1E1 and 1E2). The HCMV antigen sequences are inserted as indicated either separately or combined as 2A-linked polycistronic expression constructs into different MVA insertion sites, including the MVA Deletion 3 (De13) site or intergenic regions between open reading frames 044/045 (44/45), 064/065 (64/65), or 069/070 (69/70). Examples are provided for rsMVA vectors expressing all PC subunits (sMVA-PC1 (Figure 10A) and sMVA-P02 (Figure 10B)), all PC
subunits together with gB and pp65 (sMVA-7Ag1 (Figure 10C) and sMVA-7Ag2 (Figure 10D)), or all PC subunits, gB, and pp65 together with 1E1/1E2 antigens (sMVA-8Ag1/2 (Figures 10E-10F)) and sMVA-9Ag2 (Figures 10G-10H)). mH5 represents Vaccinia modified H5 promoter, and ITR represents inverted terminal repeats.

[0021] Figures 11A-11B show sMVA characterization. Figure 11A: FOR
analysis. CEF infected with sMVA, derived with FPV HP1.441 (sMVA hp) or TROVAC from two independent virus reconstitutions (sMVA tv1 and sMVA tv2), were investigated by FOR for several MVA genome positions (ITR sequences, transition left or right ITR into internal unique region (left ITR/UR, UR/right ITR), DeI2, IGR69/70 and Del3 insertion sites, and F1/F2 and F2/F3 recombination sites) and absence of BAC vector sequences. FOR reactions with wtMVA-infected and uninfected cells, without sample (mock), or with MVA BAC were performed as controls. Figure 11B: Restriction fragment length analysis. Viral DNA isolated from ultra-purified sMVA (sMVA tv1 and sMVA tv2) or wtMVA virus was compared by Kpnl and Xhol restriction enzyme digestion.

[0022] Figures 12A-12D show sMVA replication properties. The replication properties of sMVA derived with FPV HP1.441 (sMVA hp) or TROVAC from two independent sMVA virus reconstitution (sMVA tv1 and sMVA tv2) were compared with wtMVA. Figure 12A: Viral foci. CEF infected at low multiplicity of infection (M01) with the reconstituted sMVA virus or wtMVA were immunostained using anti-Vaccinia polyclonal antibody (aVAC). Figure 12B: Replication kinetics. BHK or CEF
cells were infected at 0.02 MOI with sMVA or wtMVA and viral titers of the inoculum and infected cells at 24 and 48 hours post infection were determined on CEF.
Mixed-effects model with the Geisser-Greenhouse correction was applied; at 24 and 48 hours post-infection differences between groups were not significant.
Figure 12C: Viral foci size analysis. BHK or CEF cell monolayers were infected at 0.002 MOI with sMVA or wtMVA and areas of viral foci were determined at 24 hours post infection following immunostaining with aVAC antibody. Figure 12D: Host cell range analysis. Various human cell lines (HEK293, A549, 143b, and HeLa), CEF
or BHK cells were infected at 0.01 MOI with sMVA or wtMVA and virus titers were determined at 48 hours post infection on CEF. Dotted lines indicate the calculated virus titer of the inoculum based on 0.01 MOI. Differences between groups in Figures 120-12D were calculated using one-way ANOVA followed by Tukey's (20) or Dunnett's (2D) multiple comparison tests. ns = not significant.

[0023] Figures 13A-13D demonstrate sMVA in vivo immunogenicity. sMVA
derived either with FPV HP1.441 (sMVA hp) or TROVAC from two independent virus reconstitution (sMVA tv1 and sMVA tv2) was compared by in vitro analysis with wtMVA. 057BL/6 mice were immunized twice at three-week interval with low (1x107 PFU) or high (5x107 PFU) dose of sMVA or wtMVA. Mock-immunized mice were used as controls. Figure 13A: Binding antibodies. MVA-specific binding antibodies (IgG titer) stimulated by sMVA or wtMVA were measured after the first and second immunization by ELISA. Figure 13B: NAb responses. MVA-specific NAb titers induced by sMVA or wtMVA were measured after the booster immunization against recombinant wtMVA expressing a GFP marker. Figures 13C-13D: T cell responses. MVA-specific IFNy, TNFa, IL-4, and IL-10-secreting 0D8+ (13C) and 0D4+ (13D) T cell responses induced by sMVA or wtMVA after two immunizations were measured by flow cytometry following ex vivo antigen stimulation using immunodominant peptides. Differences between groups were evaluated using one-way ANOVA with Tukey's multiple comparison test. ns = not significant.

[0024] Figures 14A-14D demonstrate sMVA immunogenicity in vivo. sMVA
derived either with FPV strain HP1.441 (sMVA hp) or with FPV strain TROVAC
from two independent virus reconstitution (sMVA tv1 and sMVA tv2) was compared by in vitro analysis with wtMVA. 057BL/6 mice (N=4) were immunized twice in a three-week interval with low (1x107 PFU) or high (5x107 PFU) dose of sMVA or wtMVA.
Mock-immunized mice were used as controls. Figure 14A: Binding antibodies.
Shown is the absorbance at 450 nm at different serum dilutions of MVA-specific binding antibodies (IgG titer) measured by ELISA after the first and second immunization in mice receiving sMVA or wtMVA. Figure 14B: NAb responses.
MVA-specific NAb titers induced by sMVA or wtMVA were measured after the booster immunization against wtMVA expressing a GFP marker. Shown is the measured GFP area of infected cells in square pixels (pix2x103) at different serum dilutions. Figures 14C-14D: T cell responses. MVA-specific 0D8+ (14C) and 0D4+

(14D) T cells expressing IFNy, TNFa, IL-4, and IL-10 were measured after two immunizations with sMVA or wtMVA by flow cytometry following ex vivo antigen stimulation using Vaccinia A19L immunodominant peptides. Differences between groups were evaluated using one-way ANOVA with Tukey's multiple comparison test. ns = not significant.
DETAILED DESCRIPTION

[0025]
Disclosed herein are methods of producing poxvirus-based vectors and recombinant poxvirus vectors from circularized or linearized, naturally derived or chemically synthesized DNA. Specific examples are provided herein to produce a fully synthetic version of MVA (sMVA) from circularized synthetic DNA
fragments as well as recombinant sMVA (rsMVA) expressing one or more heterologous gene sequences, including fluorescence markers or infectious disease and cancer antigens.

[0026] Because of its excellent safety profile in addition to its versatile expression system and large capacity to accommodate foreign DNA sequences (up 30 kbp)1, MVA is widely used to develop recombinant vaccine vectors against infections disease and cancer7,12,13. MVA has been pursued to develop different vaccine strategies for cancer treatment14,16 as well as various vaccine approaches to prevent human cytomegalovirus (HCMV) infection16-18, a common cause of permanent birth defects in newborns and complications in transplant recipients18.
Some of these vaccines have completed clinical phase I or ll evaluation14,17.
As a member of the poxvirus family, MVA replicates entirely in the cytoplasm of infected cells, providing its own enzymes for transcription and DNA replication1,20.
Although MVA virus production is abortive because of a late block in assembly in mammalian cells, MVA can efficiently infect most mammalian cells, including human cells, and initiate robust gene expression and DNA replication, making MVA an ideal vehicle to efficiently deliver and express foreign antigens in vitro and in vivo1,6. The most commonly used method to generate MVA recombinants is based on the so-called transfection/infection method using a transfer plasmid, which is co-delivered together with MVA into permissive cells (CEF or BHK), thereby inserting a desired antigen together with an upstream promoter sequence and downstream transcription termination signal into the MVA genome by spontaneous homologous recombination1,6,21.

[0027] Although this method is widely used, it can be laborious and is hampered by several rounds of selection during antigen insertion and additionally during subsequent marker removal to obtain homogenous populations of recombinant MVA21. These drawbacks in the conventional transfection/infection method can be particular problematic for the generation of multiantigenic MVA
vectors with antigens inserted into two or more insertion sites, which can reduce MVA vaccine stability18,22. As an alternative to the conventional transfection/infection method and to facilitate the generation of multiantigenic MVA vectors, methods have been developed to generate MVA recombinants using bacterial artificial chromosome (BAC) techn010gy23-25. These methods allow repeated manipulation to insert antigens into the MVA genome by highly efficient and versatile mutagenesis techniques and to reconstitute homogenous virus populations of recombinant MVA
in BHK cells with Fowl poxvirus (FPV) as a helper virus, which is required to "jump-start" the transcription of the non-infectious MVA gen0me23.
CONSTRUCTION OF SYNTHETIC PDXVIRUSES

[0028]
Disclosed herein are methods of producing poxvirus-based vectors or recombinant poxvirus vectors from naturally derived or chemically synthesized DNA.
In certain embodiments, a single DNA fragment is derived from viral DNA or chemically synthesized and comprises the entire genome sequence of a poxvirus.

This single DNA fragment can be used to transfect a host cell such that the poxvirus is reconstituted. In other embodiments, two or more naturally derived or chemically synthesized DNA fragments, or a combination thereof, are used to co-transfect a host cell, wherein each DNA fragment comprises a partial sequence of the poxvirus genomic DNA with overlapping sequences at the ends of two adjacent DNA
fragments, such that when the two or more DNA fragments are co-transfected into the host cell, they assemble with each other by homologous recombination to form a poxvirus comprising a full-length sequence of the desired poxvirus genome. In certain embodiments, the overlapping sequence is between about 100 bp and about 5000 bp in length.

[0029] In certain embodiments, a shortened genomic sequence rather than the entire genomic sequence or an altered genomic sequence with deletion(s) or modification(s) in non-essential genes or regions of the genomic sequence of a poxvirus, or a hybrid derivative comprising the genomic sequences from two or multiple different poxviruses can be used to produce vectors disclosed herein.

[0030] In certain embodiments, one or more naturally derived or chemically synthesized DNA fragment(s) comprising the poxvirus genome or subgenomic DNA
may be further modified to form artificial hybrid fragments composed of natural and synthetic poxvirus genomic DNA sequences. In other embodiments, the naturally derived or chemically synthesized one or more DNA fragment(s) maybe composed of sequences derived from two different poxviruses to form poxvirus hybrid sequences. One or more DNA fragment(s) can be composed of poxvirus sequences or sequences composed of different poxvirus sequences derived from MVA (NCB!
accession #U94848, #AY603355), Vaccinia virus (#NC_006998, #LT966077), Came!pox virus (#NC_003391), Cowpox virus (#NC_003663) Ectromelia virus (#NC_004105), Monkeypox virus (#NC_003310), Racoonpox virus (#NC_027213), Skunkpox virus (#NC_031038), Taterapox virus (#NC_008291), Variola virus (#NC_001611, #L22579), Velopox virus (#NC_031033), Canarypox virus (#NC_005309), Swinepox virus (#NC_003389), FPV (#NC_002188, #MH734528), Myxoma virus (#GQ409969), Sheeppox virus (NC_004002), Goatpox virus (#NC_004003), (Orf virus #NC_005336), Rabbit fibroma virus (#NC_001266), any strain variations of these poxviruses, or any other poxvirus or strain variations thereof.

[0031] In certain embodiments, the host cell is infected with a helper virus such as FPV before, during, or after the transfection of one or more DNA
fragments comprising the sequence of the poxvirus genome or subgenomic DNA. A helper virus can be any suitable virus that infects the host cell and allows initiation of the transcription and replication of the poxvirus. Used herein as an example is FPV in the host cell without undergoing homologous recombination with the poxvirus DNA.
The helper virus is unable to replicate in the host cell. Furthermore, the helper virus itself is not a component of the reconstituted poxvirus, e.g., FPV for the purposes of this application. In certain embodiments, cowpox virus, Shope fibroma virus, or other suitable poxviruses can be used as a helper virus. In certain embodiments, one or more DNA fragments for transfection can be linearized, circularized, or a combination of linearized and circularized DNA fragments. In certain embodiments, one or more DNA fragments for transfection are cloned into a vector such as a plasmid or a BAC and/or maintained in a host cell such as a bacterial cell, e.g., E.
coil.

[0032] In certain embodiments, one or more DNA fragment(s) further comprise one or both of the inverted terminal repeat (ITR) regions of the poxvirus. In certain embodiments, the sequence of the ITR may contain one or more alterations or variations, which do not affect the design scheme of the reconstituted poxvirus. In one embodiment, the one or more DNA fragments that reconstitute the poxvirus may contain only parts of the ITR sequences. For example, the sMVA fragments F1 and F3 as well as the reconstituted sMVA vectors or recombinant sMVA vectors (Figure 1-4) may contain only parts of the MVA ITR sequences. In certain embodiments, one or more DNA fragment(s) are further modified to add a poxvirus terminal hairpin loop (HL) sequence at one end or both ends as a duplex copy (double stranded DNA) or the 5' and/or 3' ends as a single stranded nucleotide sequence. For example, the HL sequence can be added to either end or both ends of a synthetic DNA fragment as double-stranded or single-stranded DNA sequence in sense (5' 4 3') or anti-sense (3' 4 5') orientation. In certain embodiments, one or more DNA
fragment(s) are further modified to add a poxvirus concatemeric resolution (CR) sequence at one end or both ends as double stranded DNA sequence or at the 5' and/or 3' ends as a single stranded nucleotide sequence. The CR sequence can be based on any sequence derived from the consensus sequence 5'-T6-N7_9-T/C-A3-T/A-3', wherein A is adenine, C is cytosine, G is guanine, T is thymine, and N
is any nucleotide. In certain embodiments, two CR sequences can be added to both ends of the HL sequence to form a CR-HL-CR sequence. The CR-HL-CR sequence can be added to one or more DNA fragment(s) to one end or both ends as double stranded DNA sequences, or to the 5' end, 3' end, or both ends as single stranded nucleotide sequences. In other embodiments, only the HL or CR sequence is added to one end or both ends of one or more DNA fragment(s) as double or single stranded DNA sequence. In certain embodiments, all the DNA fragments contain the HL or CR sequence or a combination thereof at one or both ends. In other embodiments, not all the DNA fragments contain the HL or CR sequence. In certain embodiments, only a subset or a subpopulation of the DNA fragments contain the HL
or CR sequence, or a combination thereof. The ITR, HL or CR sequences maybe derived from MVA (NCB! accession #U94848, #AY603355), Vaccinia virus (#NC_006998, #LT966077), Came!pox virus (#NC_003391), Cowpox virus (#NC_003663) Ectromelia virus (#NC_004105), Monkeypox virus (#NC_003310), Racoonpox virus (#NC_027213), Skunkpox virus (#NC_031038), Taterapox virus (#NC_008291), Variola virus (#NC_001611, #L22579), Velopox virus (#NC_031033), Canarypox virus (#NC_005309), Swinepox virus (#NC_003389), FPV (#NC_002188, #MH734528), Myxoma virus (#GQ409969), Sheeppox virus (NC_004002), Goatpox virus (#NC_004003), (Orf virus #NC_005336), Rabbit fibroma virus (#NC_001266), any strain variations of these poxviruses, or any other poxvirus or strain variation thereof.

[0033] In certain embodiments, the HL or CR sequences used herein are disclosed as follows:

[0034] Sequence of terminal CR-HL-CR sequences containing a duplex copy of the MVA terminal hairpin loop (HL) flanked by MVA concatemeric resolution sequences (215 bp in length, 5' 4 3') (SEQ ID NO: 1), wherein the CR sequences are underlined and the HL sequence is italicized and double underlined:
thttttctadacactaaataaatagtaagattaaattaattataaaattatgtatataatattaattataaaattatgt atatga tttactaactttagttagataaattaataatacataaattttagtatattaatattataaattaataatacataaattt tagtatatt aatattatattttaaatatttatttagtgtctagaaaaaaa

[0035] Sequence of terminal CR-HL-CR sequences containing a duplex copy of the complementary form of the MVA terminal hairpin loop (HL) flanked by concatemeric resolution sequences (215 bp in length, 5' -> 3') (SEQ ID NO: 2), wherein the CR sequences are underlined and the HL sequence is italicized and double underlined:
tttttttctadacactaaataaata tttaaaa ta taatattaa tatactaa aattta tgtattatta atttataatattaatatacta aaattta tgtattatta a ttta tcta actaa agttagta aatcatatacata atttta ta a tta atattata tacataattttataatt aatttaatcttactatttatttacitcitctaciaaaaaaa

[0036] Sequence of the MVA terminal hairpin loop (HL, 165 nt in length, 5' 4 3') (SEQ ID NO: 3):
gtaagattaaattaattataaaattatgtatataatattaattataaaattatgtatatgatttactaactttagttag ataaatt aataatacataaattttagtatattaatattataaattaataatacataaattttagtatattaatattatattttaaa

[0037] Sequence of the complementary form of the MVA terminal hairpin loop (HL, 165 nt in length, 5' -> 3') (SEQ ID NO: 4):
tttaaaatataatattaatatactaaaatttatgtattattaatttataatattaatatactaaaatttatgtattatt aatttatcta actaaagttagtaaatcatatacataattttataattaatattatatacataattttataattaatttaatcttac

[0038] Sequence of terminal CR-HL-CR sequences containing a duplex copy of the Vaccinia terminal hairpin loop (HL, S-Form) flanked by concatemeric resolution sequences (154 bp in length, 5' -> 3') (SEQ ID NO: 5), wherein the CR
sequences are underlined and the HL sequence is italicized and double underlined:
tttttttcta d a ca cta a ata a a a tatttaaaatataatattaatgtactaaaacttatatattattaatttatctaactaaagtta gtaaattatatatataattttataattaatttaattttactaattttatttacitcitctaciaaaaaaa

[0039] Sequence of terminal CR-HL-CR sequences containing a duplex copy of the Vaccinia terminal hairpin loop (HL, F-Form) flanked by concatemeric resolution sequences (154 bp in length, 5' -> 3') (SEQ ID NO: 6), wherein the CR
sequences are underlined and the HL sequence is italicized and double underlined:
tttttttcta d a ca cta a ata a a a ttagtaaaattaaattaattataaaattatatatataatttactaactttagttagataaatt aataatatataagttttagtacattaatattatattttaaatattttatttacitcitctaciaaaaaaa

[0040] Sequence 1 of the Vaccinia virus terminal hairpin loop (HL, S-form, 104 nt in length, 5' 4 3') (SEQ ID NO: 7):
tagtaaaattaaattaattataaaattatatatataatttactaactttagttagataaattaataatatataagtlit agtacat taatattatattttaaat

[0041] Sequence 2 of the Vaccinia virus terminal hairpin loop (HL, F-form, 104 nt in length, 5' 4 3') (SEQ ID NO: 8):
atttaaaatataatattaatgtactaaaacttatatattattaatttatctaactaaagttagtaaattatatatataa ttttataat ta attta a tttta cta

[0042] Sequence 1 of the MVA concatemer resolution sequences (CR, 20 bp in length, 5' 4 3') (SEQ ID NO: 9, sense orientation), included at the left end of the hairpin duplex copy in the working example:
tttttttcta g a ca cta a a t

[0043] Sequence 2 of the MVA concatemer resolution sequences (CR, 20 bp in length, 5' 4 3') (SEQ ID NO: 10, antisense orientation), included at the right end of the hairpin duplex copy in the working example:
atttagtgtctagaaaaaaa

[0044] As demonstrated in the working examples, sMVA and rsMVA
recombinants disclosed herein are generated based on chemical synthesis of three -60 kbp long DNA fragments that encompass the entire -178 kbp of the MVA
genome published by Antoine and colleagues (Accession# U94848)26. This includes the internal unique region (UR) and the flanking -9.6 kbp long inverted terminal repeat (ITR) regions as illustrated in Figure 1. The MVA genome sequence published by Antoine et al. (Accession# U94848)26, herein referred to as MVA
strain Antoine, differs precisely in five base pairs in the internal UR from the MVA
genome of the licensed and commercially available National Institute of Health clone 1 from 1974 (MVA NIH clone 1), which is identical in sequence to the published genome of MVA strain Acambis (Accession# AY603355). sMVA fragment 1 (F1) encompasses the left ITR and -50 kbp of the left end of internal UR of the MVA genome, sMVA
fragment 2 (F2) contains -60 kbp of the middle part of the internal UR of the MVA
genome, and sMVA fragment 3 (F3) encompasses -50 kbp of the right end of the internal UR and the right ITR of the MVA genome (Figure 1). sMVA F1 and F2 as well as sMVA F2 and F3 are designed to share -3 kbp overlapping sequences to allow the reconstitution of the complete MVA genome by homologous recombination (Figure 1). A duplex copy of the 165-nucleotide long MVA terminal HL flanked by MVA CR sequences is added to both ends of each of the three fragments to promote MVA genome resolution and packaging26 (Figure 1). In addition, Sfil and Fsel restriction sites are included at both ends of each of the three fragments in a way that the fragments can be released or linearized with or without the HL and CR

sequences. The sole exception is the HL and CR sequences at the ITR of F1 and F3 that are fused to the ends in identical arrangement as it occurs at the junctions of MVA concatemeric replication intermediates26 (Figure 1). The three sMVA
fragments with flanking HL and CR sequences as well as overlapping homologous recombination sequences as depicted in Figure 1 were synthesized and generated using a yeast-based recombination system by Genscript Biotech. All three sMVA
fragments were cloned into a yeast shuttle vector, termed p001-Brick, which contains a bacterial mini-F replicon element that can be used as a BAC vector to stably propagate the three fragments at low copy number in bacteria (Figure 1). The sMVA fragments were ultimately cloned into recombination defective DH1OB or EPI300 E. coil cells.

[0045] In certain embodiments, a duplex copy of the HL with flanking CR
sequences at both ends of each of the three MVA fragments is included - as opposed to only at the ends at the ITR of F1 and F3 where they occur naturally in concatemeric replication intermediates. This design is based on the intrinsic functions that these sequence elements have during poxvirus DNA replication.
The terminal HL in packaged poxvirus genomes connects the two DNA strands at the genomic termini to a continuous polynucleotide chain, where they exist at both ends in inverted and complementary forms that are incompletely base-paired and AT-rich26-29. Poxvirus HL sequences are important for the replication of the double-stranded DNA genomes into multimeric head-to-tail or head-to-head concatemeric replication intermediates, in which the HL sequences are present at the concatemeric junctions as precise duplex c0pie539-32. The CR elements are comprised of a highly conserved poxvirus resolution sequence and can be found in packaged genomes at both ends of the large ITRs directly adjacent to the terminal H L26,27,33,34. Poxvirus CR elements in concatemeric replication intermediates are present on either site of the HL duplex copies at the genomic junctions, and these CR/HL/CR sequence arrangements are essential for the resolution of unit-length genomes and subsequent genome packaging33-36. When circular plasmids containing poxvirus concatemeric junctions, which are composed of an HL duplex copy flanked by CR elements, are transfected into poxvirus infected cells they are spontaneously resolved into linear minichromosomes with terminal HL36,37. In certain embodiments, the circularized sMVA fragments, when transfected into the host cell, can immediately replicate in the host cell in an origin independent manner. It was reported that any circular DNA molecule transfected into poxvirus infected cells is replicated in an origin independent manner, and this non-specific sequence replication is not enhanced by insertion of any viral DNA fragments38. In other embodiments, the circularized sMVA fragments, when transfected into the host cell, can be replicated by a eukaryotic or viral origin of replication inserted into the vector or MVA sequences.

[0046] The disclosed construction technique of the synthetic poxvirus such as sMVA includes the HL and CR sequences such that transfection of circular plasm ids or DNA molecules containing the three synthetic MVA fragments with flanking concatemeric genomic junctions (CR-HL-CR) and overlapping genome sequences into FPV-infected BHK or CEF cells will promote (1) the transcription and replication of the three sMVA fragments, (2) the resolution of the three sMVA fragments from the plasmid vector sequences, and (3) the recombination of the three sMVA
fragments into full-length genomes, ultimately leading to the packaging of vector-free genomes with terminal HL into preformed virus particles (Figures 1 and 2).
These events may be initiated immediately as a consequence of the FPV infection or they may occur in a step-wise process following transcription initiation and replication of the three sMVA fragments. In another embodiment, the reconstitution process of the sMVA from the three sMVA fragments may be initiated without FPV or other helper virus. In an alternative to this strategy to reconstitute sMVA from the three MVA
fragments using circular plasmids or DNA molecules, the reconstitution of sMVA
may also be promoted by an approach based on linearized forms of the three sMVA
fragments using for example the added Fsel and Sfil restriction sites as shown in Figures 1 and 2.

[0047]
Regardless of whether using circular or linearized forms of the three MVA fragments or a combination of circular and linearized forms, the ends of the fragments may or may not contain HL and CR sequences. In certain embodiments, only a subset of the fragments may contain the HL and CR sequences, or they may be added to only one end or two ends of the fragments as single or double stranded DNA sequences in sense or antisense orientation, for example in a way that they are only present at the MVA partial sequences of F1 and F3 where they occur naturally in putative concatemeric replication intermediates. In another example, not all F1 fragments contain the HL and CR sequences; rather, F1 fragments with or without the HL and CR sequences may be mixed in the construction process. Likewise, not all F2 or F3 fragments are required to contain the HL and CR sequences but a subset or a subpopulation of F2 or F3 fragments may contain the HL and CR
sequences. In certain embodiments, HL and/or CR sequences may also be chemically ligated as single or double stranded DNA sequences in linearized forms of the three fragments.

[0048] In another embodiment, the sMVA virus reconstituted from the sMVA
fragments may be modified by introducing insertions, deletions, or point mutations, or by insertion with one or more heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof. These modifications or antigen sequences may be introduced into the sMVA DNA fragment by conventional transfection/infection methods using a transfer plasmid with homology flanks that mediate homologous recombination. In certain embodiments, the one or more nucleotide sequences encoding the one or more antigens, subunits or fragments thereof may be codon optimized for eukaryotic or vaccinia expression. For example, the antigens, subunits or fragments thereof may be optimized for stability in transcription or expression in the host cell. Various codon optimization techniques may be used, including but not limited to the alteration of four of the same nucleotides in a row (e.g. GGGG, CCCC, TTTT, AAAA) by introducing silent point mutations that do not lead to amino acid changes in the encoded protein, or the adaption of the codon usage to a specific host species.

[0049] In another embodiment, the sMVA virus reconstituted from the sMVA
fragments in a host cell such as BHK or CEF cells may be used to generate an sMVA bacterial artificial chromosome (BAC) containing a full length sMVA
genome.
The BAC vector sequences may be inserted into the sMVA genome by a transfer construct containing the BAC sequences with flanking homology sequences that mediate homologous recombination. Circular replication intermediates with inserted BAC sequences may be isolated from host cells such as BHK or CEF cells and transferred by electroporation or chemical transformation into E. coil cells that allow stable propagation of large DNA constructs, such as DH1OB or EPI300. In another embodiment, the sMVA BAC may be transferred into GS1783 E. coil cells and manipulated by Red-recombination techniques such as En passant mutagenesis.

[0050] In another embodiment, the sMVA fragments may be used to reconstitute a complete or full-length sMVA genome by in vitro ligation methods or by other in vitro DNA assembly methods such as Gibson or Golden Gate assembly.

EXPRESSION OF ANTIGENS OR OTHER HETEROLOGOUS GENE
SEQUENCES

[0051] The technology disclosed herein has the flexibility of inserting various antigens, subunits or fragments thereof, or other heterologous DNA sequences into the one or more naturally derived or chemically synthesized DNA fragment(s) before transfection such that upon reconstitution, a synthetic poxvirus expressing the antigens, subunits or fragments thereof is obtained. These antigens, subunits or fragments thereof maybe derived from or based on viruses such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), Kaposi-Sarcoma-associated herpesviruses (KSHV), other herpesviruses, Zika virus, Lassa virus, Hepatitis C virus (HCV), Hepatitis (HBV), Coronaviruses (such as 2019-nCoV, SARS, MERS), Influenza, or any other viral, bacterial, or other forms of infectious pathogen. The antigen sequences may also be derived from or based on cancer-associated proteins (e.g., p53, Retinoblastioma, neoantigens). Likewise, other heterologous gene sequences may be inserted into the naturally derived or chemically synthesized poxvirus DNA
fragment(s). Such heterologous gene sequences include but are not limited to fluorescence markers, cDNA copies of RNAs such as RNAi, shRNA, LNCRNA, miRNA, etc., interferons, cytokines, antibodies or fragments thereof, or other proteins expressed in prokaryotic or eukaryotic cells. In certain embodiments, the antigen sequences or heterologous gene sequences maybe inserted into the sMVA
fragments with an upstream natural or synthetic poxvirus promoter (pSyn, P11, H5, mH5, P28, ATI, pHyb, p7.5) and a downstream transcription termination signal (TTTTTAT), such that the antigen sequences or heterologous gene sequences are expressed when the poxvirus fragments are transfected into a host cell.

[0052] The DNA
sequences of the antigens, subunits or fragments thereof, or other heterologous gene sequences, can be inserted into one or more poxvirus insertion sites within the one or more DNA fragment(s). Using sMVA as an example, the DNA sequence of one antigen or fragment thereof can be inserted in a single MVA insertion site located on one sMVA DNA fragment, e.g., sMVA F2, before transfection of the host cell (Figure 3). In another example, the DNA
sequences of two or more antigens or fragments thereof can be inserted into a single MVA
insertion site located on one DNA fragment, e.g., sMVA F2, before transfection of the host cell. These antigen DNA sequences may be under the control of a single promoter or two or more promoters. Likewise, the antigen DNA sequences may share the same transcription termination signal or have different transcription termination signals. The nucleotide sequences encoding two or more antigens may also be linked by 2A sequences of picornaviruses (P2A, T2A, F2A, etc.) mediating ribosomal skipping or by internal ribosomal entry sites (IRES) such that the antigens are processed following translation and self-assembled to form a multi-component antigen complex.

[0053] In certain embodiments, one or more DNA sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA
sequences are inserted in frame at the 5' end, 3' end, or any internal position of one or more essential or non-essential poxvirus open reading frames (ORFs) such that when the one or more naturally-derived or chemically synthesized poxvirus DNA fragments are transfected into the host cell, one or more fusion proteins composed of a poxvirus protein with one more antigens, subunits or fragments thereof, or other heterologous protein sequences added to the C-terminus, N-terminus, or any internal position of the poxvirus proteins are expressed. In some embodiments, the one or more DNA
sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA sequences are linked to the one or more poxvirus ORFs by 2A
encoding sequences of picornaviruses (P2A, F2A, T2A etc,) such that the expressed one or more fusion proteins composed of a poxvirus protein with one more antigens, subunits or fragments thereof, or other heterologous protein sequences added to the C-terminus, N-terminus, or any internal position of the poxvirus proteins are processed ("cleaved") into the individual components at the 2A linker sequences by a ribosomal skipping mechanism. In other embodiments, the one or more DNA
sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA sequences are linked to one or more essential or non-essential poxvirus ORFs by internal ribosomal entry site sequences such that when the one or more naturally-derived or chemically synthesized poxvirus DNA fragments are transfected into the host cell, one or more poxvirus proteins and one more antigens, subunits or fragments thereof, or other heterologous protein sequences are simultaneously expressed through chimeric polycistronic expression constructs with multiple translation initiation sites at the 5' end of each of the ORFs within the expression constructs.

[0054] In certain embodiments, the DNA sequences of two or more antigens, subunits or fragments thereof or other heterologous gene sequences may be inserted into two or more MVA insertion sites, which may be located on the same sMVA fragment or on different sMVA fragments. For example, the DNA sequences of two or more antigens, subunits or fragments thereof can be inserted in two different MVA insertion sites, both located on sMVA F1. In another example, the DNA sequences of two or more antigens, subunits or fragments thereof can be inserted into two different MVA insertion sites, one located on sMVA F1 and the other located on sMVA F2 (Figure 4). It is understood that different DNA
fragments may be inserted with the DNA sequence of the same antigen, subunits or fragments thereof. Alternatively, different sMVA fragments may be inserted with the DNA
sequences of different antigens, subunits or fragments thereof such that upon reconstitution after transfection, the different antigens, subunits or fragments thereof expressed by the synthetic MVA are self-processed and self-assembled into a viral particle, a viral complex, or a complete antigen comprising the subunits or fragments thereof.

[0055] As demonstrated in the working examples, previously established methods of generating recombinant MVA vectors using BAC technology16,18,24,25 were adapted to generate rsMVA recombinants using the three sMVA fragments.
Because the three sMVA fragments have been cloned into a BAC vector with mini-F
replicon they can be stably propagated in bacteria and, consequently, they can be manipulated by highly efficient recombination methods such as En Passant mutagenesis or other E.co/i-based manipulation procedures39,40. Using these methods, naturally derived or synthetic heterologous antigen sequences together with an upstream vaccinia virus promoter and downstream transcription termination signal can be inserted into only one, two, or all three of the sMVA fragments in a parallel, successive, or repeated manner into virtually every MVA genome position (Figures 3 and 4). These insertion sites may include commonly used insertion sites such as the MVA deletion 2 (De12) site, the intergenic region (IGR) between open reading frame (ORF) 44L and 45L (IGR44/45), the IGR between ORF 69R and 70L
(IGR69/70), the IGR between 64L and 65L (IGR64/65), the Thymidine Kinase (TK) gene insertion site, or the MVA Deletion 3 (De13) site (Figure 1), or any other MVA
deletion site, intergenic region, or gene insertion site (ORF numbers are based on MVA strain Antoine (Accession# U94848)). These methods may also be used to generate one or multiple point mutations, insertions, or deletions at one or multiple positions of one or more of the sMVA fragments. The modified sMVA fragments can be then isolated from E. coil and co-transferred as circular or linearized DNA

molecules by various transfection methods into BHK or CEF cells infected with a helper virus to initiate the reconstitution of rsMVA with single, double, or multiple antigen insertions or genome alterations (Figures 3 and 4). In certain embodiments, the rsMVA reconstitution can be initiated without the addition of a helper virus. In certain embodiments, the three sMVA fragments may also be used to generate sMVA with single or multiple antigen insertion or genome alterations by in vitro ligation methods. In certain embodiments, one or more antigens, subunits or fragments thereof can be inserted into one or more MVA insertion sites of the sMVA
fragments. In certain embodiments, only one sMVA fragment is inserted with one or more antigens or fragments thereof (Figure 3). In certain embodiments, two or more sMVA fragments are inserted with one or more antigens or fragments thereof (Figure 4). In certain embodiments, all sMVA fragments are inserted with one or more antigens, subunits or fragments thereof (Figure 4). When two or more sMVA
fragments are inserted with antigens, subunits or fragments thereof, the antigens, subunits or fragments thereof may be the same or different for different sMVA
fragments. For example, sMVA Fl may be inserted with one type of antigen or fragment thereof, and sMVA F2 may be inserted with a different type of antigen or fragment thereof. Alternatively, sMVA Fl and F2 may be inserted with the same type of antigen or fragment thereof and sMVA F3 may be inserted with the same type of antigen or fragment thereof or with a different type of antigen, subunit or fragment thereof.

[0056] The poxvirus vectors produced by the technology disclosed herein may be used, for example, to generate multi-antigenic vaccine vectors to stimulate polyfunctional humoral and cellular immune response against various conditions such as viral infections and cancer. As an example, the disclosed technology based on the three sMVA fragments Fl-F3 may be used to generate multi-antigenic rsMVA
vaccine vectors to stimulate polyfunctional humoral and cellular immune response against human cytomegalovirus (HCMV). This may include immunodominant antigen sequences based on the five subunits of the HCMV pentamer complex (PC), glycoprotein B (gB), phosphoprotein 65 (pp65), and the immediate-early 1 and 2 proteins (1E1 and 1E2). The antigen sequences may be inserted separately or combined as 2A-linked polycistronic expression constructs into the sMVA
fragments at different commonly used MVA insertion sites (DeI2, DeI3, IGR44/45, IGR69/70, IGR64/65) to generate rsMVA vaccine vectors expressing 5, 6, 7, 8, or 9 HCMV
antigens, as illustrated in Figure 6 and Figure 10. rsMVA vectors expressing only single HCMV antigens or any other number or combination of the above-mentioned nine HCMV antigens may also be generated. All antigen sequences or expression constructs may be inserted together with an upstream mH5 promoter and downstream transcription termination signal. These vectors may be used to stimulate immune responses against HCMV in animal models or humans.
EXPRESSION SYSTEMS AND VACCINES

[0057]
According to the embodiments described herein, an MVA expression system is provided herein. In certain embodiments, the expression system may express one or more desired antigens, subunits or fragments thereof or other heterologous protein sequences.

[0058] As described above, one or more sMVA fragments may be inserted with the DNA sequences encoding one or more antigens, subunits or fragments thereof such that the reconstituted sMVA simultaneously expresses the antigens, subunits and fragments thereof.

[0059] In certain embodiments, the antigen DNA sequences inserted into the sMVA fragments may be based on the natural DNA sequence or from chemical synthesis. In other embodiments, the antigen DNA sequences may be optimized for expression and stability within the expression system.

[0060] The sMVA
described herein may be part of a vaccine composition that may be used in methods to treat or prevent viral infection or to treat cancer, depending on the antigens expressed by the sMVA. The vaccine composition as described herein may comprise a therapeutically effective amount of the sMVA
as described herein, and further comprising a pharmaceutically acceptable carrier according to a standard method. Examples of acceptable carriers include physiologically acceptable solutions, such as sterile saline and sterile buffered saline.

[0061] In some embodiments, the vaccine or pharmaceutical composition may be used in combination with a pharmaceutically effective amount of an adjuvant to enhance the prophylactic or therapeutic effects. Any immunologic adjuvant that may stimulate the immune system and increase the response to a vaccine, without having any specific antigenic effect itself may be used as the adjuvant. Many immunologic adjuvants mimic evolutionarily conserved molecules known as pathogen-associated molecular patterns (PAMPs) and are recognized by a set of immune receptors known as Toll-like Receptors (TLRs). Examples of adjuvants that may be used in accordance with the embodiments described herein include Freund's complete adjuvant, Freund's incomplete adjuvant, double stranded RNA (a TLR3 ligand), LPS, LPS analogs such as monophosphoryl lipid A (MPL) (a TLR4 ligand), flagellin (a TLR5 ligand), lipoproteins, lipopeptides, single stranded RNA, single stranded DNA, imidazoquinolin analogs (TLR7 and TLR8 ligands), CpG DNA (a TLR9 ligand), Ribi's adjuvant (monophosphoryl-lipid A/trehalose dicorynoycolate), glycolipids (a-GalCer analogs), unmethylated CpG islands, oil emulsion, liposomes, virosomes, saponins (active fractions of saponin such as QS21), muramyl dipeptide, alum, aluminum hydroxide, squalene, BOG, cytokines such as GM-CSF and IL-12, chemokines such as MIP 1-a and RANTES, activating cell surface ligands such as CD4OL, N-acetylmuramine-L-alanyl-D-isoglutamine (MDP), and thymosin al. The amount of adjuvant used can be suitably selected according to the degree of symptoms, such as softening of the skin, pain, erythema, fever, headache, and muscular pain, which might be expressed as part of the immune response in humans or animals after the administration of this type of vaccine.

[0062] In further embodiments, use of various other adjuvants, drugs or additives with the vaccine of the invention, as discussed above, may enhance the therapeutic effect achieved by the administration of the vaccine or pharmaceutical composition. The pharmaceutically acceptable carrier may contain a trace amount of additives, such as substances that enhance the isotonicity and chemical stability.
Such additives should be non-toxic to a human or other mammalian subject in the dosage and concentration used, and examples thereof include buffers such as phosphoric acid, citric acid, succinic acid, acetic acid, and other organic acids, and salts thereof; antioxidants such as ascorbic acid; low molecular weight (e.g., less than about 10 residues) polypeptides (e.g., polyarginine and tripeptide) proteins (e.g., serum albumin, gelatin, and immunoglobulin), amino acids (e.g., glycine, glutamic acid, aspartic acid, and arginine), monosaccharides, disaccharides, and other carbohydrates (e.g., cellulose and derivatives thereof, glucose, mannose, and dextrin), chelating agents (e.g., EDTA), sugar alcohols (e.g., mannitol and sorbitol), counterions (e.g., sodium); nonionic surfactants (e.g., polysorbate and poloxamer), antibiotics; and PEG.

[0063] The vaccine or pharmaceutical composition containing the sMVA
described herein may be stored as an aqueous solution or a lyophilized product in a unit or multiple dose container such as a sealed ampoule or a vial.
PREVENTING OR TREATING VIRAL INFECTIONS OR CANCER

[0064] The poxvirus reconstituted from the one or more naturally derived or chemically synthesized DNA fragment(s), with or without the inserted antigens, subunits or fragments thereof, or other heterologous sequences may be used as a vaccine composition for preventing or treating various viral infections or cancer. One of ordinary skill in the art would know how to select a particular viral or cancer antigen for the conditions or diseases to be prevented or treated. This may include but is not limited to any infectious disease or cancer antigen that is capable of eliciting an immune response, such as viral envelope glycoproteins or glycoprotein complexes, immunodominant T cell antigens, or mutated cancer neoantigens.
These antigen sequences or portions thereof maybe derived from or based on viruses such as CMV, EBV, KSHV, other herpesviruses, Zika virus, Lassa virus, HCV, HBV, Coronaviruses, Influenza, or any other viral, bacterial, or other forms of infectious pathogen.

[0065] The following examples are intended to illustrate various embodiments of the invention. As such, the specific embodiments discussed are not to be constructed as limitations on the scope of the invention. It will be apparent to one skilled in the art that various equivalents, changes, and modifications may be made without departing from the scope of invention, and it is understood that such equivalent embodiments are to be included herein. Further, all references cited in the disclosure are hereby incorporated by reference in their entirety, as if fully set forth herein.

EXAMPLES
Example 1: Reconstitution of sMVA using circular forms of the synthetic MVA
fragments

[0066] As an initial test to validate the sMVA platform, a procedure as illustrated in Figure 2 was used to evaluate the reconstitution of sMVA from circular forms of the three sMVA fragments. The three sMVA fragments (F1 to F3) were isolated by alkaline 1y5i541 from EPI300 or DH1OB E. coil, which allows stable propagation of large DNA fragments cloned as a BAC, and co-transfected (-1-2 pg/fragment) as circular plasmids by lipofection into monolayers of BHK cells (6 well plate format) (Figure 5). At 4 hours post infection (hpi), the BHK cells were infected with a helper FPV at 0.1 multiplicity of infection (M01) to initiate MVA
transcription and DNA replication. FPV-infected BHK cells transfected with only one or a combination of only two of the MVA fragments, mock-infected (uninfected) BHK
cells transfected with all three MVA fragments, and mock-transfected BHK cells infected with FPV were used as controls. Transfected/infected BHK cells were grown under appropriate conditions and every 2 days dispersed (passaged) in -1:2 to 1:3 ratios into larger tissue culture formats using a procedure as illustrated in Figure 5.
Cytopathic effects (ORE) and signs of viral plaque formation and progression demonstrating reconstitution of sMVA were detected in FPV-infected BHK cell monolayers transfected with all three synthetic MVA fragments at 3-6 days post transfection/infection (dpt/i). At 7 to 8 dpt/i following dispersion of the FPV-infected BHK cells transfected with all three MVA fragments, the derived BHK cell monolayers showed 90-100% infection. In contrast, ORE or signs of characteristic MVA viral plaque formation were not observed in any of the controls. sMVA was prepared from BHK cell monolayers with 100% ORE by conventional freeze/thaw method, titrated on BHK cells, and used to infect BHK cell monolayers at low MOI to evaluate MVA infection and spreading at 16-72 hpi by immunostaining for the vaccinia virus glycoprotein B5R16,42.

[0067] This analysis indicated that the reconstituted sMVA had similar capacity compared to MVA NIH clone 1 to form characteristic MVA viral foci and to spread in BHK cell monolayers (Figure 6), confirming the formation of sMVA
from the three sMVA fragments. Characteristic viral foci were detected in sMVA and MVA
NIH-infected BHK cell monolayers at 1 day post infection (dpi), while at 2 dpi MVA

viral infection was visible in the entire BHK cell monolayers infected with sMVA or MVA NIH, and at 3 dpi most cells of the BHK cell monolayers infected with sMVA
or MVA NIH were detached. In contrast, no characteristic MVA viral infection or CPE
was detected in mock-infected controls. Other research groups conclusively demonstrated that FPV, used as a helper virus, contributes no genetic material or recombines with the MVA genome when introduced into the transfection/infection incubation on BHK or CEF cells43,44.

[0068] To characterize the genome of the reconstituted sMVA, viral DNA
prepared from sMVA-infected BHK cells was evaluated by FOR using primers specific for different genome positions within the three synthetic MVA
fragments.
DNA prepared from mock-infected (uninfected) BHK cells as well as BHK cells infected with the NIH MVA clone 1 were used as controls. This FOR analysis revealed the presence of DNA derived from all three sMVA fragments within the genomic DNA of the reconstituted sMVA (Figure 7). All FOR products derived from sMVA-infected BHK cells were similar (in molecular weight) compared to those derived from MVA NIH-infected BHK cells. This included (1) FOR products derived from the ITR sequences located within sMVA F1 and F3 (Figure 7A), (2) FOR
products corresponding to sMVA Fl-derived DNA such as the transition of the left ITR into the left end of the internal UR (Figure 7B), and the Del2 insertion site (Figure 70), (3) FOR products corresponding to sMVA F2-derived DNA such as the G1L/I8R insertion site (IGR69/70) (Figure 7D), and FOR products corresponding to sMVA F3-derived DNA such as the Del3 insertion site (Figure 7E), the transition of the right end of the internal UR into the right ITR (Figure 7F). In addition, FOR
analysis using primers with binding sites flanking the sMVA F1/F2 or sMVA

overlapping homologous sequences (Figure 1) showed similar product sizes for MVA
and MVA NIH-infected BHK cells (Figures 7G-7H), indicating successful recombination of the three sMVA fragments and removal of the vector sequences in sMVA.

[0069] Sanger sequencing analysis of all FOR products derived from sMVA-infected BHK cells revealed sequences at these genome positions that were identical to the published sequence of MVA strain Antoine26, including the recombination sites of F1/F2 and F2/F3. The only exception to this was the FOR

product derived from the Del2 site of sMVA showing a single T to A nucleotide alteration located in the IGR at three base pairs downstream of open reading frame (OR F) 021L26. BLAST analysis showed that this sequence alteration within sMVA

DNA is not present in any published MVA or vaccinia virus genome sequence.
Sanger sequences analysis of sMVA F1 purified from E. coil indicated that this specific nucleotide alteration at the Del2 site was already present before the sMVA
reconstitution in BHK cells, suggesting that it has its origin in the chemical synthesis of F1 or is a result of the cloning or propagation of sMVA F1 in E. coil.
Additional sequencing analysis of FOR products (Figures 7I-7L) derived from sMVA-infected BHK cells indicated that the sMVA genome sequence contained all five Antoine specific nucleotide polymorphisms in the internal UR that distinguishes it from the genome sequence of the MVA NIH clone 1.

[0070] The following DNA sequences are given as the nucleotide sequences (5' to 3') of the sense strands of the DNA molecules. Sequence of sMVA
fragment 1 (F1, 60021 bp in length) (SEQ ID NO: 11):
ggcctagcaggccggcctttttttctagacactaaataaatagtaagattaaattaattataaaattatgtatataata ttaa ttataaaattatgtatatgatttactaactttagttagataaattaataatacataaattttagtatattaatattata aattaata atacataaattttagtatattaatattatattttaaatatttatttagtgtctagaaaaaaatgtgtgaccaacgaccg tagga aactctagagggtaagaaaaatcaatcgctttatagagaccatcagaaagaggtttaatatttttgtgagaccatcgaa ggagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaag agataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaac thtttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaaacttttttacgac tc catcagaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaaacttttttacgactccatcagaaag aggtttaatatttttgtgagaccatcgaaggagaaagagataaaacttttttacgactccatcagaaagaggtttaata ttt ttgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagac c atcgaaggagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagaga gaaagagaataaaaatattttagtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaag agataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaaact t ttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttacgac tc catcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaactthttacgactccatcagaaa gaccatcgaagagagaaagagaaagagatagttagtctagatatttttcttagtacaaaagtcaatgttttaaaatata t ggacaagaatttgtctgtataaaaacttgtgtgaaattligtaccaaagaaaaaatgtgagcagtatcccctacatgga t tttactagatcatttatataccaaaaaatattatacgatctacgttttattatatgattttaacgtgtaaattataaac attatttta tgatatacaattgtctggtaacctagatgggcataggggatgagtatatgttgliggacgttattgtttaagaaatagt tgat gcatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaa agaggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttatgactccattgaagagagaatga gaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagaccatcaaagagagaaagagaata aaaatattttatgactccattgaagagagaaagagaaaatgagaataaaaatattttagtgacaccatcagaaagag gtttaatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatc aaa gagagaaagagaataaaaatatttttgtaaaactlittttatgagaccatcaaagagagaaagagaataaaaatatttt t gtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatc aa agagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatattt ttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactthtttatgagaccat ca aagagagaaagagaataaaaatattttatgactccattgaagagagaaagagaataaaaatattttagtgacaccat cagaaagaggtttaatatlittgtgagaccatcgaagagagaaagagaataaaaatattttatgactccattgaagag agaaagagaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagaccatcaaagagagaaa gagaataaaaatattlitgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaac ttt ttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaa agagaataaaaatatttligtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaa ct thtttatgagaccatcaaagagagaaagagaataaaaatattttatgactccattgaagagagaatgagaataaaaa tattttagtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagaataaaaatatttta t gactccattgaagagagaaagagaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagacc atcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaa aatatttttgtaaaactttlittatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttat gagac catcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataa aaatatttligtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaacttttttta tgaga ccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaata aaaatattttatgactccattgaagagagaatgagaataaaaatattttagtgacaccatcagaaagaggtttaatatt tt tgtgagaccatcgaagagagaaagagaataaaaatattttatgactccattgaagagagaatgagaataaaaatatt ttagtgacaccatcagaaagaggtttaatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgta a aactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaaattataaacattattttatgata tac aattgtctggtaacctagatgggcataggggatgttgataagctcgacgagtatatgttgttggacgttattgtttaag aa atagttgatgcatcagaaagagaataaaaaatattttagtgagaccatcgaagagagaaagagataaaactthttac gactccatcagaaagaggtttaatatlittgtgagaccatcgaagagagaaagagataaaacttttttacgactccatc agaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaaacttttttacgactccatcagaaagaggt ttaatatttttgtgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaa ga gagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttg t aaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactlittttatgagaccatcaa ag agagaaagagaataaaaatattttatgactccattgaagagagaatgagaataaaaatattttagtgacaccatcag aaagaggtttaatattlitgtgagaccatcgaagagagaaagagaataaaaatattttatgactccattgaagagaga atgagaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagaccatcaaagagagaaagag aataaaaatatttttgtaaaacttlitttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaacttt tttta tgagaccatcaaagagagaaagagaataaaaatattthgtaaaactlittttatgagaccatcaaagagagaaaga gaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatattttatgactccat tg aagagagaatgagaataaaaatattttagtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaagaga gaaagagaataaaaatattttatgactccattgaagagagaaagagaataaaaatattttagtgacaccatcagaaa gagglitaatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaacttthttatgagacca tc aaagagagaaagagaataaaaatattttatgactccattgaagagagaatgagaataaaaatattttagtgacacca tcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagaataaaaatattttatgactccattgaagag agaatgagaataaaaatattttagtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaag agaataaaaatattttatgactccattgaagagagaatgagaataaaaatattttagtgacaccatcagaaagaggttt aatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttlittatgagaccatcaaag ag agaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgt a aaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtgagaccatcaaagagagaaagaga ataaaaatatttttgtgagaccatcaaagagagaaagagaataaaaatatlittgtgagaccatcaaagagagaaag agaataaaaatattttatgactccattgaagagagaaagagaataaaaatattttagtgacaccatcagaaagaggtt taatatttttgtgagaccatcgaagagagaaagagaataaaaatattttatgactccattgaagagagaaagagaata aaaatattttagtgacaccatcagaaagagglitaatatlitttatgagaccatcaaagagagaaagagaataaaaat attttttatgagaccatcaaagagagaaagagaataaaaatattttatgagaccatcaaagagagaaagagaataa aaatatttlitatgagaccatcaaagagagaaagagaataaaaatattttatgagaccatcaaagagagaaagaga ataaaaatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgtatgagaccatcagaaagaggtt taatatttttgtgataccctgaaaggaaataggaatagtgtcataatcgtatcacactattgagacagaaaaagaagaa gtcgcgagaggtaactttttgttttgcaaaccggaatatagtgtccggtacacttttttaattcgtggtgtgcctgaat cgttc gattaaccctactcatccaatttcagatgaatagagttatcgattcagacacacgctttgagttttgttgaatcgatga gtg aagtatcatcggttgcaccttcagatgccgatccgtcgacatacttgacctcaagttcagatgattccttgcacatgtc tcc gatacgaacgctaaactctagattcttgacacattttgtatcgacgatcgttgaaccgatgatatcttcgtaactcact ttctt atgagagatgttagacccgagtactggatgggtcttgatgtcgctgtctttctcttcttcgctacatctgatgtcgata gaca cctcacagtctttccatcagcggattctgagatggatttaatctgaggacatttggtgaatccaaagttcattctcaga cct ccaccgatgatggagtaataagtggtaggaggatctacatcctcgactgattccacctcgggatctggatctgactcgg actctgtaatttccgttacggattggcaaatcttatcatcggtcggtgtttggtcttgctttgtgactttgataataac atcgatt cccatatgatgtttgttttcttcttccgtacacgatgaggatgattgctgaagactggcaggcacatgcatgccagtac ga tatattgtttcatgattgctattgattgagtactglictttatgattctacttccttaccgtgcaataaattagaatat attttctactt ttacgagaaattaattattgtatttatgggtgaaaaacttactataaaaagcgggtgggtliggaattagtgatcagtt tatg tatatcgcaactaccgggcatatggctacattacccacatgataagagattgtatcagtttcgtagtcttgagtattgg tatt actatatagtatatagatgtcgacgctagagttactgtctccgaatgcggcatgatagtatcattctttgctttcgtta actgtt tggaggaagaatctttgttattgcatttaatctcgaaattcagagtgcacacctttctcctgtaaagaaacctgaagtc gct accttattaagaagacgggatcgcagtctttatgattcatagtaatagttagttccgacgttgagatggattcgctgag ac cggtagtggtcgtccgagtacacgatgtgtcgttaactggatacaggttaatttccacatcgatatagttaaaggtatt tct gggtacgggttcgcatttatctgcggaagagacggtgtgagaatatgttccgagaccacacggagaacagatgacgt ctccggatactccgtatcctattccacattttgtttgggaaacacatgccttgcatccatgatcgggagagcattcaca ga ttctattgtgagtcgtgttacacgatcgcgtcgacattgttgacagaaacgtgaccttcattcttaccgtcgtccataa atac gttaggtatgtaccacatactgtcgcgaacgatgcgtccatctcataatgatttactttttcataattaaagatgtgaa aga aaaccgaacaatatatttttttagtaatgtttatgcgagacatataaaataaactccgtgtttatgatgccggtaaatg ttttt atcatcttggacggaatcgattttgtaatatgccatggaaacaggacattatcactccatgataaattatttaatggag tc gatcctctcattgttctttgcgtatctcaatctgtggcgtttgcttcgtttaaataatatatcaaacatggagacgcct gatatg taggcattcttcattctattaatgtctgctctatagcgctttagttccttatgacgaccggcgatatcatacttacttt agaagg aaaatcatcatctaggattaaggcgtatctgatacaggcgaataatggttcaggatatagatagcgtatatctctatta a atgcgtcaatcatagtctctagagtgggatggtaactcagtaataaatcaactagcttctctttggtaactgcttttct ggat ggccgtattgattatcgagcgtgacactcgctccatattccaataaccgctttgcaaattgtatattattgacatcgac cgc gtaatatagtagagttatcgatcatatctatatcatccatgtacttgcttagtatatcaaatacatcttcataacagtg atacc cgcaattattaaatctcgataatatcagaccgtacatacatagacggccattgttagatatgtgatttacagccgcgtg tc catattttccacgataaaccttacgacgtttacatcgacgagattattattaacaaagttgttgtccgtcgtcttatcc aacat gcattgaatgataggtatacttaccatatcgccgtaatgtaagtagtttatcagtatggcttgtacgatggattcatcc tgtt gtctaaatctctttagaatgttatcgatgatgtagtggttatattctctggaatcgtacgaagtaatactacgcattac gtcg acaagagtatgacgtctctcaataagaagattaacgatttccatgtctacattatatggggttactctaaatcgcttgt ttag ataatacgcctctaatatagggctgacgtcgtatactctacacgtgtccacatcctttattaataatctctatatctat ggttg agcaagaccagtagtattggatggaaacattgttatcgatcaaacatttaattacatccttggatagagattctctatg ag acgatatatagtaatgaagagagttcttacacatatcactgttgtacatacaggtacgaaatacgtaaccggtgctgta acattctgatttaagaagccatagcaatacttctggtctcggattaggcgtcgttacgtatatatccaccaatccgaga cc attgattgcataattcgtattcttggacggacgtatccgtttatccacaattaggtattttagcagacgtaagtcgaaa tcatt tatattcgacttgagttcgttagaggaattcgaatagctggatatcagtagatgcacaatctgagattttacgtatcta tgct tactgtatgctcctagcggagttaatccttcgttgtttctacaaagtctctcgactccgcgagagagtaacagtcgaac aa tcttaatgtctgtatcgcatttattggagacgtaacaatgtagcgcattgtttcctcgtctatctatatgttttgataa gttgtgac acgtttcaatttctagttttatttttttgtacgtcacatcttcatccagtagacgacatagaatacatgtgcaatccat agctatt ctggtgctaattattcctcataagatgataaaaagtgtagtgagagagcatgaaggagatttagtatttagcagtgcgg atatgatccaagagggtgagatagtcgttctcgttcagaatctttcgcagcataagtagtatgtcgatatacttatcgt tga agactcttccagagacgatagctgattgagtacaaagtccaatgattgcacgaagttcttcggcggttttcatggagtc a tttctgatgaaacatttaatgatctaaatttcagtttatgtttgtaccccgtattcatacttaacaaattggtattaca taccatta ataatgcaagcataaaaaatcgttagtagatgtttctaaatataggttccgtaagcaaagaatataagaatgaagcgg taatgataaaatcaatcgttatctaaaatgatcatactcatttattttattctattatattaacacatacatttttaac agcaac acattcaatattgtattgttatttttatattatttacacaattaacaatatattattagtttatattactgaattaata atataaaatt cccaatcttgtcataaacacacactgagaaacagcataaacacaaaatccatcaaaaatgttgataaattatctgatg ttgttgttcgctgctatgataatcagatcattcgccgatagtggtaacgctatcgaaacgacatcgccagaaattacaa a cgctacaacagatattccagctatcagattatgcggtccagagggagatggatattgtttacacggtgactgtatccac gctagagatatcgacggtatgtattgtagatgctctcatggttatacaggcattagatgtcagcatgtagtattagtag act atcaacgttcagaaaaaccaaacactacaacgtcatatatcccatctcccggtattatgcttgtattagtaggcattat tat tattacgtgttgtctattatctgtttataggttcactcgacgaactaaactacctatacaagatatggttgtgccataa tlittat aaattttttttatgagtatttttacaaaaatgtataaagtgtatgtcttatgtatatttataaaaatgctaaatatgcg atgtatct atgttatttgtatttatctaaacaatacctctacctctagatattatacaaaaattttttatttcggcatattaaagta aaatcta gttaccttgaaaatgaatacagtgggtggttccgtatcaccagtaagaacataatagtcgaatacagtatccgattgag attttgcatacaatactagtctagaaagaaatttgtaatcatcttctgtgacgggagtccatatatctgtatcatcgtc ccat gctatattcctgttatcatcattagttaatgaaaataactctcgtgcttcagaaaagtcaaatattgtatccatacata catct ccaaaactatcgcttatacgtttatctttaacgatacctatacctagatggttatttactaacagacattliccagatc tattg actataactcctatagtttccacatcaaccaagtaatgatcatctattgttatataacaataacataactcttliccgt ttttatc agtatgtatatctatatcaacgtcgtcgttgtagtgaatagtagtcattgatctattatatgaaacggatatgtctaga acgg caattgttttacgtccagttaacactttcgttgatttaaagtctagagtctttgcaaacataatatccttatccgactt tatatttc ctgtagggtggtataattttattttgcctccacatatcggtgtttccaaatatattactagacaatattccatatagtt attagtt aagggtacccaattagaacacgtacgcttattatcatcatttggatcgtatttcataaaagttattgtactatcgatgt caac acattctacattttttaatcgtctatatagtatttttctgatattttctataatatcagaattgtcttccatcggaagt tgtatactatc ggaatcagttacatgtttaaataattctctgatgtcattccttatacaatcaaattcattattaaacagtttaatagtc tgtaga cctttatcgtcgtaaatatccattgtcttattagttacgcttatttttatgtgtttttacgttgctttattatatttta taagaatgattgtt tgacgaatcacgagaactattaagacacattattaggtatatattataaaaaagtttttgattacgatgttataagagg aa agaggacacattaacatcatacatcaattaactacattcttataacatcgtaatcaaaagaattgcaattttgatgtat aa caactgtcaatgggttatggaattgtatattacatattatacggtatgliggtaacgacaaataccgatcggtaattgt ctg ccggtgtaatagaattatatatatctatctattacaccggccligtatacataataataagttgtggtagtatgatctc catat ttataatttaggactttgtattcagtttttttggaatcataaaaaataaaaaaaagttttactaatttaaaattattta catttttttc actgtttagtcgcggatatggaattcgatcctgccaaaatcaatacatcatctatagatcatgtaacaatattacaata ca tagatgaaccaaatgatataagactaacagtatgcattatcacaaaaataaatccacatttggctaatcaatttcgggc t tggaaaaaacgtatcgccggaagggactatatgactaacttatctagagatacaggaatacaacaatcaaaacttac tgaaactgtcaaaaaaatagaaacatatatggtctatatatacactacaatttagttattaattggataaccgatgtga tta tcaatcaatattaagaaggttggtaaattggtacatagctaataatacctatacacccaataatacaacaaccatttct g agttggatatcatcaaaatactggataaatacgaggacgtgtatagagtaagtaaagaaaaagaatgtgaaatttgct atgaagttgtttactcaaaacgatagatactttggtttattggattcgtgtaatcatatattttgcataacatgcatca atatat ggcatagaacacgaagagaaaccggtgcgtcggataattgtcctatatgtcgtacccgttttagaaacataacaatga gcaagttaactaataaataaaaagtttaatttgttgacgacgtatgtcgttattttttctcgtataaaagattaatttg attcta atataatctttagtattggataaatatcaattcaaattaattccattagattatatcataaataaaaatagtagcacgc acta cttcagccaaatattcttttttgaaacgccatctatcgtagtgaggacacaagtgaacctataatgagcaaatttatta gta tcggttacatgaaggactttacgtagagtggtgattccactatctgtggtacgaacggtttcatcttctttgatgccat cacc cagatgttctataaacttggtatcctttgccaaccaatacatatagctaaactcaggcatatgttccacacatcctgaa ca atgaaattctccagaagatgttacaatgtctagatttggacatttggtttcaaccgcgttaacatatgagtgaacacac cc atacatgaaagcgatgagaaataggattttcatcttgccaaaatatcactagaaaaaatttatttatcaattttaaagg tat aaaaaatacttattgttgctcgaatattttgtatttgatggtatacggaagattagaaatgtaggtattatcatcaact gattc tatggttttatgtattctatcatgtttcactattgcgttggaaataatatcatatgcttccacatatattttattttgt tttaactcata atactcacgtaattctggattattgacatatctatgaataattttagctccatgatcagtaaatattaatgagaacata gtatt accacctaccattattthttcatctcattcaattcttaattgcaaagatctatataatcattatagcgttgacttatgg actctg gaatcttagacgatgtacagtcatctataatcatggcatatttaatacattgttttatagcatagtcgttatctacgat gttag atatttctctcaatgaatcaatcacacaatctaatgtaggtttatgacataatagcattttcagcagttcaatglittt agattc gttgatggcaatggctatacatgtatatccgttatttgatctaatgttgacatctgaaccggattctagcagtaaagat act agagattgtttattatatctaacagccttgtgaagaagtgtttctcctcgtttgtcaatcatgttaatgtctttaagat aaggta ggcaaatgtttatagtactaagaattgggcaagcataagacatgtcacaaagaccctttttgtatgtataagtgtaaaa a ttataacattcatagttggatttacataggtgtccaatcgggatctctccatcatcgagataattgatggcatctccct tccttt tttagtagatatttcatcgtgtaagaatcaatattaatatttctaaagtatccgtgtatagcctctttatttaccacag ttccatat tccactagagggatatcgccgaatgtcatatactcaattagtatatgttggaggacatccgagttcattgttttcaata tca aaaagatggtttccttatcatttctccatagtggtacaatactacacattattccgtgcggctttccattttccaaaaa caattt gaccaaatctacatclitattgtatctataatcactatttagataatcagccataattactcgagtgcaacatgttaga tcgt ctatatatgaataagccgtgttatctattcctttcattaacaatttaacgatgtctatatctatatgagatgacttaat ataatat tgaagagctgtacaatagtttttatctataaaagacggcttgattccgtgattaattagacatttaacaacttccggac gca catatgctctcgtatccgactctgaatacagatgagagatgatatacagatgcaatacggtaccgcaatttcgtagttg a taatcatcatacgcgtatcagtactcgtcctcataaagaacactgcagccattttctatgaacaaatcaataatttcag ga acaggatcatctgtcattacataattttctataactgaacgatggttttcacatttaacactcaagtcaaatccatgtt ctacc aacacctttatcaagtcaacgtctacatttttggatttcatatagctgaatatattaaagtcatttatgttgctaaatc cagtgg cttctagtagagccatcgctatatcctttaactttaacatgtctactatttgtgtattcttctaatggggtagctgtct ccaattttt gcgtaatggattagtgccactgtctagtagtagtttgacgacctcgacattattacaatgctcattaaaaaggtatgcg tgt aaagcattattcttgaattggttcctggtatcattaggatctctgtctctcaacatctgtttaagttcatcgagagcca cctcct cattttccaaatagtcaaacattttgactgaatgagctactgtgaactctatacacccacacaactaatgtcattaaat atc atgtcaaaaacttgtacaattattaataaaaataatttagtglitaaattttaccagttccagattttacacctccgtt aaccc cactlittacaccactggacgatcctcctccccacattccaccgccaccagatgtataaglittagatcctttattact acca tcatgtccatggataaagacactccacatgccgccactaccccctttagaagacatattaataagacttaaggacaag tttaacaataaaattaatcacgagtaccctactaccaacctacactattatatgattataglitctattlitacagtac cttaa ctaaagtctctagtcacaagagcaatactaccaacctacactattatatgattatagtlictattlitataggaacgcg tac gagaaaatcaaatgtctaatttctaacggtagtgttgataaacgattatcgtcaatggatacctcctctatcatgtcgt ctat tlicttactttglictattaacttattagcattatatattatttgattataaaacttatattgcttattagcccaatct gtaaatatcgg attattaacatatcgtlictligtagglitatttaacatgtacatcactgtaagcatgtccgtaccatttattttaatt tgacgcata tccgcaatttctlittcgcagtcggttataaattctatatatgatggatacatgctacatgtgtacttataatcgacta atatga agtacttgatacatattlicagtaacgatttattattaccacctatgaataagtacctgtgatcgtctaggtaatcaac tglitt cttaatacattcgatggttggtaatttactcagaataatttccaatatcttaatatataattctgctatttctgggata tatttatct gccagtataacacaaatagtaatacatgtaaacccatattttgttattatattaatgtctgcgccattatctattaacc attct actaggctgacactatgcgacttaatacaatgataaagtatactacatccatglitatatcatcaatatacggcttaca aa glittagtatcgataacacatccaactcacgcatagagaaggtagggaataatggcataatatttattaggttatcatc at tgtcattatctacaactaaglitccattlittaaaatatactcgacaactttaggatctctattgccaaattlitgaaa atatttatt tatatgcttaaatctatataatgtagctccttcatcaatcatacatttaataacattgatgtatactgtatgataagat acatat tctaacaatagatcligtatagaatctgtatatclittaagaattgtggatattattacgtaaactattacacaattct aaaata taaaacgtatcacggtcgaataatagttgatcaactatataattatcgattligtgatttlicttcctaaactglitac gtaaat agttagatagaatattcattagttcatgaccactatagttactatcgaataacgcgtcaaatatttcccgtttaatatc gcatt tgtcaagataataatagagtgtggtatglicacgataagtataataacgcatctctlittcgtgtgaaattaaatagtt tatta cgtccaaagatgtagcataaccatcligtgacctagtaataatataataatagagaactglittacccattctatcatc ata atcagtggtgtagtcgtaatcgtaattgtctaattcatcatcccaattataatattcaccagcacgtctaatctglict attlig atcligtatccatactgtatgligctacatgtaggtattcctttatccaataatagtttaaacacatctacattgggat ttgatgtt gtagcgtatttlictacaatattaataccattlitgatactatttatttctatacclitcgaaattagtaatttcaata agtctatatc gatgttatcagaacatagatattcgagtatatcaaaatcattgatattlitatagtcgactgacgacaataacaaaatc ac aacatcgtlittgatattattattlitcliggtaacgtatgcctttaatggaglitcaccatcatactcatataatgga tttgcacc actlictatcaatgattgtgcactgctggcatcgatgttaaatglittacaactatcatagagtatcttatcgttaacc atgatt ggttgttgatgctatcgcattlittgglitclitcatttcagttatgtatggatttagcacgtttgggaagcatgagct catatgatt tcagtactgtagtgtcagtactattaglitcaataagatcaatctctagatctatagaatcaaaacacgataggtcaga a gataatgaatatctgtaggclicttgligtactgtaacttctcgttligttagatglitgcatcgtgctttaacatcaa tggtaca aattttatcctcgctttgtgtatcatattcgtccctactataaaattgtatattcagattatcatgagatgtgtatacg ctaacgg tatcaataaacggagcacaccatttagtcataaccgtaatccaaaaattlitaaagtatatcttaacgaaagaagligt g tcattgtctacggtgtatggtactagatcctcataagtgtatatatctagagtaatgtttaatttatcaaatggttgat aatatg gatcctcatgacaatttccgaagatggaaatgagatatagacatgcaataaatctaattgcggacatggttactcctta a aaaaatacgaataatcaccttggctatttagtaagtgtcatttaacactatactcatattaatccatggactcataatc tcta tacgggattaacggatglictatatacggggatgagtagttttcttctttaactttatactttttactaatcatattta gactgatg tatgggtaatagtgtttaaagagttcgttctcatcatcagaataaatcaatatctctgtlittttgttatacagatgta ttacagc ctcatatattacgtaatagaacgtgtcatctaccttattaactttcaccgcatagttgtttgcaaatacggttaatcct ttgacc tcgtcgatttccgaccaatctgggcgtataatgaatctaaactttaatttcttgtaatcattcgaaataatttttagtt tgcatcc gtagttatcccctttatgtaactgtaaatttctcaacgcgatatctccattaataatgatgtcgaattcgtgctgtata cccat actgaatggatgaacgaataccgacggcgttaatagtaatttacttlitcatctttacatattgggtactagttttact atcat aagtttataaattccacaagctactatggaataagccaaccatcttagtataacacacatgtcttaaagtttattaatt aatt acatgttgttttatatatcgctacgaatttaaacagagaaatcagtttaggaaaaaaaaatatctatctacatcatcac gt ctctgtattctacgatagagtgctactttaagatgagacatatccgtgtcatcaaaaatatactccattaaaatgatta ttcc ggcagcgaacttgatattggatatatcacaacctttgttaatatctacgacaatagacagcagtcccatggttccataa a cagtgagtttatctttctttgaagagatattttgtagagatcttataaaactgtcgaatgacatcgcatttatatcttt agctaa atcgtatatgttaccatcgtaatatctaaccgcgtctatcttaaacgtttccatcgctttaaagacgtttccgatagat ggtct catttcatcagtcatactgagccaacaaatataatcgtgtataacatctttgatagaatcagactctaaagaaaacgaa t cggctttattatacgcattcatgataaacttaatgaaaaatgtttttcgttgtttaagttggatgaatagtatgtctta ataattg ttattatttcattaattaatatttagtaacgagtacactctataaaaacgagaatgacataactagttatcaaagtgtc tagg acgcgtaattttcatatggtatagatcctgtaagcattgtctgtattctggagctattttctctatatctaatttctga acgttcac caatgtctctagccactttggcactaatagcgatcattcgcttagcgtcttctatattattaactggttgattcaatct atctag caatggaccgtcggacagcgtcattctcatgttcttaatcaatgtacatacatcgccgtcatctaccaattcatccaac aa cataagctttttaaaatcatcattataataggtttgatcgttgtcatttctccaaagaatatatctaataagtagagtc ctcat gattagttaacaactattttttatgttaaatcaattagtacaccgctatgtttaatacttattcatattttagttlita ggattgaga atcaatacaaaaattaatgcatcattaattttagaaatacttagtttccacgtagtcaatgaaacatttgaactcatcg tac aggacgttctcgtacaggacgtaactataaaccggtttatatttgttcaagatagatacaaatccgataacttttttta cga attctacgggatccactttaaaagtgtcataccgggttctttttatttttttaaacagattaatggtgtgatgttgatt aggtctttt acgaatttgatatagaatagcgtttacatattctccataatggtcaatcgccatttgttcgtatgtcataaattcttta attatat gacactgtgtattatttagttcatccttgttcatcattaggaatctatccaatatggcaattatactagaactataggt gcgttg tatacacatattgatgtgtctgtttatacaatccatgctactaccttcgggtaaaattgtagcatcatataccatttct agtact ttagglicattgttatccattgcagaggacgtcatgatcgcatcctaaaaaaatatattatttttatgttattttgtta aaaataa tcatcgaatacgaatcatccagtccactgaatagcaaaatctttactattttggtatcttccaatgtggctgcctgatg taat ggaaattcattctctagaagatttttcaatgctccagcgttcaacaacgtacatactagacgcacgttattatcagcta ttg cataatacaaggcactatgtccatggacatccgccttaaatgcatctttgctagagagaaagcttttcagctgcttaga ct tccaagtattaattcgtgacagatccatgtctgaaacgagacgctaattagtgtataatttttgtcatattgcaccaga atta ataatatctctaatagatctgattagtagatacatggctatcgcaaaacaacatatacacatttaataaaaataatatt tat taagaaaattcagatttcacgtacccatcaatataaataaaataatgattccttacaccgtacccatattaaggagatt ct accttacccataaacaatataaatccagtaatatcatgtctgatgatgaacacaaatggtgtattaaattccagttttt cag gagatgatctcgccgtagctaccataatagtagatgcctctgctacagttccttgttcgtcgacatctatctttgcatt ctga aacattttataaatatataatgggtccctagtcatatgtttaaacgacgcattatctggattaaacatactaggagcca tca tttcggctatcgacttaatatccctcttattttcgatagaaaatttagggagtttaagattgtacactttattccctaa ttgaaac gaccaatagtctaattttgcagccgtaatagaatctgtgaaatgggtcatattatcacctattgccaggtacatactaa tat tagcatccttatacggaaggcgtaccatgtcatattctttgtcatcgattgtgattgtatttccttgcaatttagtaac tacgttc atcatgggaaccgttttcgtaccgtacttattagtaaaactagcattgcgtgttttagtgatatcaaacggatattgcc atat acctttaaaatatatagtattaatgattgcccatagagtattattgtcgagcatattagaatctactacattagacata ccg gatctacgttctactatagaattaattttattaaccgcatctcgtctaaagtttaatctatataggccgaatctatgat attgttg ataatacgacggtttaatacacacagtattatctacgaaactttgataagttagatcagtgtacgtatatttagatgtt ttca gcttagctaatcctgatattaattctgtaaatgctggacccagatctctttttctcaaatccatagtcttcaataattc tattcta gtattacctgatgcaggcaatagcgacataaacatagaaaacgaataaccaaacggtgagaagacaatattatcat cttgaatatttttatacgctactataccggcattggtaaatccligtagacgataggtagacgctgaacacgttaacga ta gtatcaataacgcaatcatgattttatggtattaataattaaccttatttttatgttcggtataaaaattattgatgtc tacacat ccttligtaattgacatctatatatccttttgtataatcaactctaatcactttaacttttacagttttccctaccagt ttatccctat attcaacatatctatccatatgcatcttaacactctctgccaagatagcttcagagtgaggatagtcaaaaagataaat a tatagagcataatcattctcgtatactctgccctttattacatcgcccgcattgggcaacgaataacaaaatgcaagca t cttgttaacgggctcgtaaattgggataaaaattatgtttttatatctattttattcaagagaatattcaggaatttcl itttccgg ttgtatctcatcgcagtatatatcatttgtacattgtttcatattttttaatagtttacaccttttagtaggactagta tcgtacaatt catagctgtattttgaattccaatcacgcataaaaatatcttctaattgttgacgaagacctaatccatcatccggtgt aat attaatagatgctccacatgtatccgtaaagtaatttcctgtccaatttgaggtacctatataggccgttttatcggtt accat atatttggcatgglitaccctagaatacggaatgggaggatcagcatctggtacaataaatagctttacttctatattt atgt ttttagattttagcatagcgatagatcttaaaaagtttctcatgataaacgaagatcgttgccagcaactaatcaatag ctt aacggatacttgtctgtctatagcggatcttcttaattcatcttctatataaggccaaaacaaaattttacccgccttc gaat aaataatagggataaagttcataacagatacataaacgaatttactcgcatttctaatacatgacaataaagcggttaa atcattggttctttccatagtacatagttgttgcggtgcagaagcaataaatacagagtgtggaacaccacttacgtta at actaagaggatgatctgtattataatacgacggataaaagtttttccaattatatggtagattgttaactccaagatac ca gtatacctcaaaaatttgagtgagatccgctgccaagttcctattattgaagatcgcaatacccaattctttgacctga gtt agtgatctccaatccatgttagcgcttcctaaataaatatgtgtattatcagatatccaaaattttgtatgaagaactc ctcc taggatatttgtaatatctatgtatcgtacttcaactccggccatttgtagtctttcaacatcctttaatggtttgtta gatttattg acggctactctaactcgtactcctcttttgggtaattgtacaatctcgtttaatattatcgtgccgaaattcgtaccca cttcat ccgataaactccaataaaaagatgatatatctagtgtttttgtggtattggatagaatttccctccacatgttaaatgt aga caaatatactttatcaaattgcatacctataggaatagtctctgtaatcactgcgattgtattatccggattcatttta tttgtta aaagaataatcctatatcacttcactctattaaaaatccaagtttctatttctttcatgactgattttttaacttcatc cgtttcctt atgaagatgatgtttggcaccttcataaatttttatttctctattacaatttgcatgttgcatgaaataatatgcacct aaaac atcgctaatctcattgtttgttccctggagtatgagagtcggggtgttaatcttggaaattatttttctaaccttgttg gtagcctt caagacctgactagcaaatccagccttaattttttcatgattgattaatgggtcgtattggtatttataaactttatcc atatct ctagatactgattctggacatagctttccgactggcgcatttggtgtgatggttcccataagtttggcagctagcagat tca gtcttgaaacagcatctgcattaactagaggagacattagaatcattgctgtaaacaagtttggattatcgtaagaggc t agtatagaaattgttgctcccatggaatgacccaataagtagatttaatagttaccacgtgctgtaccaaagtcatcaa t catcattttttcaccattacttcttccatgtccaatatgatcatgtgagaatactaaaattcctaacgatgatatglit tcagct agttcgtcataacgtccagaatgtttaccagctccatgacttatgaatactaatgccttaggatatgtaatcattgtcc aga ttgaacatacagtttgcactcatgattcacgttatataactatcaatattaacagttcgtttgatgatcatattatttt tatgtttta ttgataattgtaaaaacatacaattaaatcaatatagaggaaggagacggctactgtcttttgtgagatagtcatggcg a ctaaattagattatgaggatgctglittttactttgtggatgatgataaaatatgtagtcgcgactccatcatcgatct aatag atgaatatattacgtggagaaatcatgttatagtgtttaacaaagatattaccagttgtggaagactgtacaaggaatt g atgaagttcgatgatgtcgctatacggtactatggtattgataaaattaatgagattgtcgaagctatgagcgaaggag accactacatcaattttacaaaagtccatgatcaggaaagtttattcgctaccataggaatatgtgctaaaatcactga a cattggggatacaaaaagatttcagaatctagattccaatcattgggaaacattacagatctgatgaccgacgataat ataaacatcttgatactttttctagaaaaaaaattgaattgatgatataggggtcttcataacgcataattattacgtt agca ttctatatccgtgttaaaaaaaattatcctatcatgtatttgagagttttatatgtagcaaacatgatagctgtgatgc caata agctttagatattcacgcgtgctagtgttagggatggtattatctggtggtgaaatgtccgttatataatctacaaaac aat catcgcatatagtatgcgatagtagagtaaacatttttatagtttttactggattcatacatcgtctacccaattcggt tatga atgaaattgtcgccaatcttacacccaaccccttgttatccattagtatagtattaacttcgttatttatgtcataaac tgtaa atgattttgtagatgccatatcatacatgatattcatgtccctattataatcattactaactttatcacaatatatgtt gataata tctatatatgatctagtctttgtgggcaactgtctatacaagtcgtctaaacgttgtttactcatatagtatcgaacag ccatc attacatggtcccgttccgttgatagataatcgagtatgttagtggacttgtcaaatctatataccatattttctggaa gtgg atatacatagtcgtgatcaacattattgctagcctcatcttctatatcctgtactataccatctacataatctacgata ttatta cacataaacatcgacaacatactattglitattatctaagtcctgttgatccaaacccttgatctcctctatttgtact atctag agattgtacttcttccagttctggataatatatacgttgatagattagctgagctattctatctccagtatttacatta aacgta cattttccattattaataagaatgactcctatgtttcccctataatcttcgtctattacaccacctcctatatcaatgc cttttagt gacagaccagacctaggagctattctaccatagcaaatcttaggcatggacatactaatatctgtcttaattaactgtc tt tctcctggagggatagtataatcgtaagcgctatacaaatcatatccggcagcacccggcgattgcctagtaggagat ttagctctgttagtttccttaacaaatctaactggtgagttaatattcatgttgaacataaaactaatattttatttca aaattatt taccatcccatatattccatgaataagtgtgatgattgtacacttctatagtatctatatacgattcacgataaaatcc tcct atcaatagcagtttattatccactatgatcaattctggattatccctcggataaataggatcatctatcagagtccatg tatt gctggattcacaataaaattccgcatttctaccaaccaagaataaccttctaccgaacactaacgcgcatgatttataa t gaggataataagtggatggtccaaactgccactgatcatgattgggtagcaaatattctgtagttgtatcagtttcaga at gtcctcccattacgtatataacattgtttatggatgccactgctggattacatctaggtttcagaagactcggcatatt aacc caagcagcatccccgtggaaccaacgctcaacagatgtgggatttggtagacctcctactacgtataatttattgttag c gggtatcccgctagcatacagtctggggctattcatcggaggaattggaatccaattglitgatatataatttacagct ata gcattgttatgtatttcattgttcatccatccaccgatgagatatactacttctccaacatgagtacttgtacacatat ggaat atatctataatttgatccatgttcataggatactctatgaatggatacttgtatgatttgcgtggttgtttatcacaat gaaatat tttggtacagtctagtatccattttacattatttatacctctgggagaaagataatttgacctgattacatttttgata aggagt agcagatttcctaatttatttcttcgctttatataccacttaatgacaaaatcctcatctggaacatttagttcatcgc tttctag aataagtttcatagatagataatcaaaattgtctatgatgtcatcttccagttccaaaaagtgtttggcaataaagttt ttagt atgacataagagattggatagtccgtattctatacccatcatgtaacactcgacacaatattcctttctaaaatctcgt ag gataaagtttatacaagtgtagatgataaattctacagaggttaatatagaagcacgtaataaattgacgacgttatga ctatctatatatacctttccagtatatgagtaaataactatagaagttagactgtgaatgtcaaggtctagacaaaccc tc gtaactggatctttatttttcgtgtatttttgacgtaaatgtgtgcgaaagtaaggagataactttttcaatatcgtag aattga ctattatattgcctcctatggcatcaataattgttttgaatttcttagtcatagacaatgctaatatattcttacagta cacagta ttgacaaatatcggcatttatgtttctttaaaagtcaacatctaaagaaaaatgattatcttcttgagacataactccc attttt tggtattcacccacacgtttttcgaaaaaattagttttaccttctaatgatatattttccatgaaatcaaacggattgg taaca ttataaatttttttaaatcccaattcagaaatcaatctatccgcgacgaattctatatatglittcatcatttcacaat tcattcct ataagtttaactggaagagccgcagtaagaaattcttgttcaatggataccgcatctgttataatagatctaacggttt ctt cactcggtggatgcaataaatgtttaaacatcaaacatgcgaagtcgcagtgtagaccctcgtctctactaatcaattc g ttggaaaacgtgagtccgggcattaggccacgctttttaagccaaaatatggaagcgaatgatccggaaaagaaga ttccttctactgcagcaaaggcaataagtctctctccataaccggcgctgtcatgtatccacttttgagcccaatcggc ctt cttttttacacaaggcatcgtttctatggcattaaagagatagtttttlicattactatctttaacataagtatcgatc aaaaga ctatacatttccgaatgaatgttttcaatggccatctgaaatccgtagaaacatctagcctcggtaatctgtacttctg taca aaatcgttccgccaaattttcattcactattccgtcactggctgcaaaaaacgccaatacatgttttataaaatatttt tcgtc tggtgttagtttattccaatcattgatatctttagatatatctacttcttccactgtccaaaatgatgcctctgccttt ttatacatg ttccagatgtcatgatattggattgggaaaataacaaatctatttggatttggtgcaaggatgggttccataactaaat taa caataacaataaattttttttcagttatctatatgcctgtacttggatcttttgtacatcgatatcgccgcaatcacta caataa ttacaagtattattgatagcattgttattagtactatcataattaaattatcgttattatcattttgtaattgtgacat catactaga taaatcgtttgcgagattgttgtgggaagcgggcatggaggatgaattatcgttattattatttaaagcctcccattcg gatt cacaaatatggcgcgcgttcaacattttatggaaacagataacaagaaaactcgtcatcgttcaaatttttaacgatag t aaaccgattaaacgtcgagctaatttctaacgctagcgactctgttggatatgggtttccagatatatatcttttcagt tccc ctacgtatctataatcatctgtaggaaatggaagatatttccatttatctactglicctaatatcatatgtggtggtgt agtag aaccattaagcgcgaaagatgttatttcgcatcgtattttaacttcgcaataatttctggttagataacgcactctacc agt caagtcaatgatattagcctttacagatatattcatagtagtcgtaacgatgactccatcttttagatgcgatactcct ttgta tgtaccagaatcttcgtacctcaaactcgatatatttaaacaagttaatgagatattaacgcgttttatgaatgatgat atat aaccagaagttttatcctcggtggctagcgctataaccttatcattataataccaactagtgtgattaatatgtgacac gtt agtgtgggtacaaatatgtacattatcgtctacgtcgtattcgatacatccgcatacagccaacaaatataaaatgaca aatactctaacgccgttcgtacccatcttgatgcggtttaataaatgttttgatttcaatttattgtaaaaaaagattc ggtttt atactgttcgatattctcattgcttatattttcatctatcatctccacacagtcaaatccgtggttagcatgcacctca tcaacc ggtaaaagactatcggactcttctatcattataactctagaatatttaatttggtcattattaatcaagtcaattatct tattttta acaaacgtgagtattttactcattttttataaaaacttttagaaatatacagactctatcgtgtgtctatatcttcttt ttatatcca atgtatttatgtctgatttttcttcatttatcatatataatggtccaaattctacacgtgcttcggattcatccagatc attaaggtt cttataattgtaacatccttctcttccctcttctacatcttccttcttattcttattcttagcgtcacagaatctacca cagcagga tcccatgacgagcgtcatattaaactaatccattttcaattataatatacgattagtaatgaccattaaaataaaaata ttct tcataaccggcaagaaagtgaaaagttcacattgaaactatgtcagtagtatacatcatgaaatgatgatatatatata ctctattttggtggaggattatatgatataattcgtggataatcattcttaagacacatttcttcattcgtaaatcttt tcacgtta aatgagtgtccatattttgcaatttcttcatatgatggcggtgtacgtggacgaggctgctcctglicttgttgtagtc gccga ctgtcgtgtctgcgtttagatccctccattatcgcgattgcgtagatggagtactattttataccttgtaattaaattt ttttattaa ttaaacgtataaaaacgttccgtatctgtatttaagagccagatttcgtctaatagaacaaatagctacagtaaaaata a ctagaataattgctacacccactagaaaccacggatcgtaatacggcaatcggttttcgataataggtggaacgtatat tttatttaaggacttaacaattgtctgtaaaccacaatttgcttccgcggatcctgtattaactatctgtaaaagcata tgttg accgggcggagccgaacattctccgatatccaatttctgtatatctataatattattaacctccgcatacgcattacag ttc ttttctagcttggataccgcactaggtacatcgtctagatctattcctatttcctcagcgatagctcttctatcctttt ccggaa gcaatgaaatcacttcaataaatgattcaaccatgagtgtgaaactaagtcgagaattactcatgcatttgttagttat tc ggagcgcgcaatttttaaactgtcctataacctctcctatatgaatagcacaagtgacattagtagggatagaatgttg a gctaattlitgtaaataactatctataaaaagattatacaaagttttaaactctttagtttccgccatttatccagtct gagaa aatgtctctcataataaatttttccaagaaactaattgggtgaagaatggaaacctttaatctatatttatcacagtct gtttt ggtacacatgatgaattcttccaatgccgtactaaattcgatatctttttcgatttctggatatgtttttaataaagta tgaaca aagaaatggaaatcgtaataccagttatglitaactttgaaattgttttttattttcttgttaatgattccagccactt gggaaa agtcaaagtcgtttaatgccgatttaatacgttcattaaaaacaaacttlitatcctttagatgaattattattggttc attgga atcaaaaagtaagatattatcgggtttaagatctgcgtgtaaaaagttgtcgcagcatggtagttcgtaaattttaatg tat aacagagccatctgtaaaaagataaactttatgtattgtaccaaagatttaaatcctaatttgatagctagctcggtat ct actttatctgccgaatacagtgctaggggaaaaattataatatttcctctttcgtattcgtagttagttctcttttcat gttcgaa aaagtgaaacatgcggttaaaatagtttataacattaatattactgttaataactgccggataaaagtgggatagtaat tt cacgaatttgatactgtcctttctctcgttaaacgcctttaaaaaaactttagaagaatatctcaatgatagttcctga ccat ccatagtttgtatcaataatagcaacatatgaagaacacgtttatacagagtatgtaaaaatgttaatttatagtttaa tcc catggcccacgcacacacgattaattttttttcatctccctttagattgttgtatagaaatttgggtactgtgaactcc gccgt agtttccatgggactatataattttgtggcctcgaatacaaattttactacatagttatctatcttaaagactatacca tatcct cctgtagatatgtgataaaaatcgtcgtttataggataaaatcgtttatccttttgttggaaaaaggatgaattaatgt aatc attctcttctatctttagtagtgtttccttattaaaattcttaaaataatttaacaatctaactgatggagcccaattt tggtgtaa atctaattgggacattatattgttaaaatacaaacagtctcctaatataacagtatctgataatctatggggagacatc ca ttgatattcaggggatgaatcattggcaacacccatttattgtacaaaaagccccaatttacaaacgaaagtccaggtt t gatagagacaaactattaactattttgtctctglitttaatttctttggtaatgaaattattcacaatatcagtatctt ctttatcta ccagagattttactaacttgataaccttggctgtctcattcaatagggtagtaatatttgtatgtgtgatattgatatc ttttaga agtgattctttgatggtgccagcatacgaattacaataatgcagaaactcggttaacatgcaggaattatagtaagcca attccaattgttgcctgtgttgtattagagtgtcaatatgagcaatggtgtccttgcgtttctctgatagaatgcgagc agcg attttggcgttatcatttgacgatatttctggaatgacgaatcctgtttctactaacttlitggtaggacaaagtgaaa caatc aagaagatagclictcctcctatttgtggaagaaattgaactcctctagatgatctccttgacagatattggaccgaat ta cagaagtacctggaatgtaaagccctgaaaccccctcattttttaagcagattgttgccgtaaatcctgcactatgccc a agatagagagctcctttggtgaatccatctctatgtttcagtttaaccaagaaacagtcagctggtctaaaatttccat ctc tatctaatacagcatctaacttgatgtcaggaactatgaccggttatgttatatgtaacattgagtaaatccttaagtt cata atcatcactgtcatcagttatgtacgatccaaacaatgtttctactggcatagtggatacgaagatgctatccatcaga at gtttccctgattagtattttctatatagctattcttctttaaacgattttccaaatcagtaactatgttcattttttta ggagtaggac gcctagccagtatggaagaggattttctagatcctctcttcaacatctttgatctcaatggaatgcaaaaccccatagt gt aacaaccaacgataaaaataatattgtttttcactttttataattttaccatctgactcatggattcattaatatcttt ataaga gctactaacgtataattctttataactgaactgagatatatacaccggatctatggtttccataattgagtaaatgaat gctc ggcaataactaatggcaaatgtataaaacaacgaaattatactagagttgttaaagttaatattttctatgagctgttc ca ataaattatttgttgtaactgcgttcaagtcataaatcatcttgatactatccagtaaaccgtttttaagttctggaat attatta tcccattgtaaagcccctaattcgactatcgaatatcctgctctgatagcagtttcaatatcgacggacgtcaatactg ta ataaaggtggtagtattgtcatcatcgtgataaactactggaatatggtcgttagtaggtacggtaactttacacaacg c gatatataactttccttttgtaccatlittaacgtagttgggacgtcctgcagggtattgttttgaagaaatgatatcg agaac agatttgatacgatatttgttggattcctgattatttactataatataatctagacagatagatgattcgataaataga gaag gtatatcgttggtaggataatacatccccattccagtattctcggatactctattaatgacactagttaagaacatgtc ttct attctagaaaacgaaaacatcctacatggactcattaaaacttctaacgctcctgattgtgtctcgaatgcctcgtaca a ggatttcaaggatgccatagattctttgaccaacgatttagaattgcgtttagcatctgatttttttattaaatcgaat ggtcg gctctctggtttgctaccccaatgataacaatagtcttgtaaagataaaccgcaagaaaatttatacgcatccatccaa a taaccctagcaccatcggatgatattaatgtattattatagattttccatccacagttattgggccagtatactgttag caac ggtatatcgaatagattactcatgtaacctactagaatgatagttcgtgtactagtcataatatctttaatccaatcta aga aatttaaaattagattttttacactgttaaagttaacaaaggtattacccggatacgtggatatcatatatggtattgg tccat tatcagtaatagctccataaactgatacggcgatggtttttatatgtgtttgatctaacgaggaagaaattcgcgccca ca attcatctctagatatgtatttaatatcaaacggtaacacatcaatttcgggacgcgtatatgtttctaaatttttaat ccaaat ataatgatgacctatatgccctattatcatactgtcaactatagtacacctagagaacttacgatacatctgtttccta taat cgttaaattttacaaatctataacatgctaaaccttttgacgacaaccattcattaatttctgatatggaatctgtatt ctcaat accgtatcgttctaaagccagtgctatatctccctgttcgtgagaacgctttcgtataatatcgatcaacggataatct gaa gtttttggagaataatatgactcatgatctatttcgtccataaacaatctagacataggaattggaggcgatgatctta attt tgtgcaatgagtcgtcaatcctataacttctaatattgtaatattcatcatcgacataacactatctatgttatcatcg tatatt agtataccatgaccttcttcatttcgtgccaaaatgatatacagtcttaaatagttacgcaatatctcaataglitcat aattg ttagctgttttcatcaaggtttgtatcctgtttaacatgatggcgttctatacgtttctattttttaaatttttaacga tttactgtggc tagatacccaatctctctcaaatatttttttagcctcgcttacaagctgtttatctatactattaaaactgacgaatcc gtgattt tggtaatgggttccgtcgaaatttgccgaagtgatatgaacatattcgtcgtcgactatcaacaattttgtattattct gaat agtgaaaaccttcacagatagatcattttgaacacacaacgcgtctagacttctggcggttgccatagaatatacgtcg ttcttatcccaattaccaactagaagtctgatcttaactcctctattaatggctgcttctataatggagttgtaaatgt cgggc caatagtagctattaccgtcgacacgtgtagtgggaactatggccaaatglicaatatctatactagtcttagccgact tg agtttatcaataactacatcagtgtctagatctctagaatatcccaataggtgttccggagaatcagtaaagaacactc c acctataggattcttaatatgatacgcagtgctaactggcagacaacaagccgcagagcataaattcaaccatgaatt ttttgcgctattaaaggctttaaaagtatcaaatcttctacgaagatctgtggccagcgggggataatcagaatataca c ctaacgttttaatcgtatgtatagatcctccagtaaatgacgcgtttcctacataacatctttcattatctgacaccca aaaa caaccgagtagtagtcccacattatttthttatctatattaacggttataaaatttatatccgggcagtgactttgtag ctctc ccagatttcttttccctcgttcatctagcaaaactattattttaatccctttttcagatgcctcttttagtttatcaaa aataagcg ctcccctagtcgtactcagaggattacaacaaaaagatgctatgtatatatatttcttagctagagtgataatttcgtt aaa acattcaaatgttgttaaatgatcggatctaaaatccatattttctggtagtglitctaccagcctacattttgctccc gcagg taccggtgcaaatggccacatttagttaacataaaaacttatacatcctgttctatcaacgattctagaatatcatcgg ct atatcgctaaaattttcatcaaagtcgacatcacaacctaactcagtcaatatattaagaagttccatgatgtcatctt cgt ctatttctatatccgtatccattgtagattgttgaccgattatcgagtttaaatcattactaatactcaatccttcaga atacaa tctgtgtttcattgtaaatttataggcggtgtatttaagttggtagattttcaattatgtatcaatatagcaacagtag ttcttgct cctccttgattctagcatcctcttcattattttcttctacgtacataaacatgtccaatacgttagacaacacaccgac gatg gcggccgccacagacacgaatatgactaaaccgatgaccatttaaaaacccctctctagctttcacttaaactgtatcg attattctlitagaacatgtataatataaaaacattattctatttcgaatttaggcttccaaaaattlitcatccgtaa accgat aataatatatatagacttgttaatagtcggaataaatagattaatgcttaaactatcatcatctccacgattagagata ca atatttacattttttttgctgtttcgaaactttatcaatacacgttaatacaaacccaggaaggagatattgaaactga ggct gttgaaaatgaaacggtgaatacaataattcagataatgtaaaatcatgattccgtattctgatgatattagaactgct aa tggatgtcgatggtatgtatctaggagtatctattttaacaaagcatcgatttgctaatatacaattatcattttgatt aattgtt attttattcatattcttaaaaggtttcatatttatcaattcttctacattaaaaatttccatttttaatttatgtagcc ccgcaatact cctcattacgtttcattttttgtctataatatccattttgttcatctcggtacatagattatccaattgagaagcgcat ttagtagtt ttgtacattttaagtttattgacgaatcgtcgaaaactagttatagttaacattttattatttgataccctgatattaa tacccct gccgttactattatttataactgatgtaatccacgtaacattggaattaactatcgatagtaatgcatcgacgcttcca aaa ttgtctattataaactcaccgataatttttttattacatgttttcatattcattaggattattaaatctttaatcttac tacgattgtat gcgttgatattgcaagacgtcattctaaaagacggaggatctccatcaaatgccagacaatcacgtacaaagtacat ggaaataggttttgttctattgcgcatcatagatttatatagaacacccgtagaaatactaatttgttttactctataa aatac taatgcatctatttcatcgttttgtataacgtctttccaagtgtcaaattccaaatttttttcattgatagtaccaaat tcttctatct ctttaactacttgcatagataggtaattacagtgatgcctacatgccgttttttgaaactgaatagatgcgtctagaag cga tgctacgctagtcacaatcaccactttcatatttagaatatatatatgtaaaaatatagtagaatttcattttgttttt tttctatg ctataaatgaattctcattttgcatctgctcatactccgttttatatcaataccaaagaaggaagatatctggttctaa aagc cgttaaagtatgcgatgttagaactgtagaatgcgaaggaagtaaagcttcctgcgtactcaaagtagataaaccctc atcacccgcgtgtgagagaagaccttcgtccccttccagatgcgagagaatgaataacccaggaaaacaagttccg tttatgaggacggacatgctacaaaatatglicgcggctaatcgcgataatgtagclictagacttttgtcctaaaata ca attatatccttttcgatattaataaatccgtgtcgtccaggttttttatctctttcagtatgtgaatagataggtattt tatctctattc atcatcgaatttaagagatccgataaacattgtttgtattctccagatgtcagcatctgatacaacaatatatgtgcac ata aacctctggcacttatttcatgtaccttccccttatcactaaggagaatagtatttgagaaatatgtatacatgatatt atcat gaattagatatacagaatttgtaacactctcgaaatcacacgatgtgtcggcgttaagatctaatatatcactcgataa c acattttcatctagatacactagacattttttaaagctaaaatagtctttagtagtaacagtaactatgcgattatttt catcg atgatacatttcatcggcatattattacgcttaccatcaaagactataccatgtgtatatctaacgtattctagcatgg ttgc catacgcgcattaaacttttcaggatctttggatagatcttccaatctatctatttgagaaaacatttttatcatgttc aatagtt gaaacgtcggatccactatatagatattatctataaagattttaggaactacgttcatggtatcctggcgaatattaaa ac tatcaatgatatgattatcgttttcatcttttatcaccatatagtttctaagatatgggattttacttaatataatatt atttcccgta ataaattttattagaaatgccaaatctataagaaaagtcctcgaattagtttgaagaatatctatatcgccgtaccgta tat ttggattaattagatatagagaatatgatccgtaacatatacaacttttattatggcgtctaagatattcttccatcaa cttatt aacatttttgactagggaagatacattatgacgtcccattacttttgccttgtctattactgcgacgttcatagaattt agcat atctcttgccaattcttccattgatgttacattataagaaattttagatgaaattacatttggagctttaatagtaaga actcct aatatgtccgtgtatgtggtcactaatacagattgtagttctataatcgtaaataatttacctatattatatgtttgag tctgttta gaaaagtagctaagtatacgatcttttatttctgatgcagatgtatcaacatcggaaaaaaatctttttttattctttt ttactaa agatacaaatatgtctttgttaaaaacagttattttctgaatatttctagcttgtaattttaacatatgatattcgttc acactag gtactctgcctaaatagglitctataatctttaatgtaatattaggaaaagtattctgatcaggattcctattcatttt gaggatt taaaactctgattattgtctaatatggtctcaacacaaactttttcacagagcgatagagtttttgataactcgttttt cttaag aaatataaaactactgtctccagagctcgctctatcttttattttatttaattcgatacaaactcctgatactggttca gaaag taattcattaattttcagtcctttatagaagatatttaatatagataatacaaaatcttcagtttttgatatcgatctg attgatcc tagaactagatatattaataacgtgctcattaggcagtttatggcagcttgataattagatatagtatattccagttca tattt attagataccgcattgcccagattttgatattctatgaattcctctgaaaataaatccaaaataactagacattctatt ttttgt ggattagtgtactctcttccctctatcatgttcactactggtgtccacgatgataaatatctagagggaatataatata gtcc ataggatgccaatctagcaatgtcgaataactgtaattttattcttcgctcttcattatgaattgattcttgaggtata aaccta acacaaattatattattagacttttcgtatgtaatgtctttcatgttataagtttttaatcctggaatagaatctattt taatgagg cttttaaacgcagagttctccaacgagtcaaagcataatactctgttggttttcttatatacgatgttacgattttctt ctttgaa tggaataggtttttgaattagtttataattacaacataatagataaggaagtgtgcaaatagtacgcggaaaaaacata atagctcccctgttttcatccatggttttaagtaaatgatcactggcttctttagtcaatggatattcgaacattaacc gtttca tcatcattggacagaatccatatttcttaatgtaaagagtgatcaaatcattgtgtttattgtaccatcttgttgtaaa tgtgtat tcggttatcggatctgctcctttttctattaaagtatcgatgtcgatctcgtctaagaattcaactatatcgacatatt tcatttgt atacacataaccattactaacgtagaatgtataggaagagatgtaacgggaacagggtttgttgattcgcaaactattc taatacataattcttctgttaatacgtcttgcacgtaatctattatagatgccaagatatctatataattattttgtaa gatgatg ttaactatgtgatctatataagtagtgtaataattcatgtatttcgatatatgttccaactctgtctttgtgatgtcta gtttcgtaa tatctatagcatcctcaaaaaatatattcgcatatattcccaagtcttcagttctatcttctaaaaaatcttcaacgta tgga atataataatctattttacctcttctgatatcattaatgatatagtttttgacactatcttctgtcaattgattcttat tcactatatct aagaaacggatagcgtccctaggacgaactactgccattaatatctctattatagcttctggacataattcatctatta ta ccagaattaatgggaactattccgtatctatctaacatagttttaagaaagtcagaatctaagacctgatgttcatata ttg gttcatacatgaaatgatctctattgatgatagtgactatttcattctctgaaaattggtaactcattctatatatgct liccttgtt gatgaaggatagaatatactcaatagaatttgtaccaacaaactgttctcttatgaatcgtatatcatcatctgaaata at catgtaaggcatacatttaacaattagagacttgtctcctgttatcaatatactattcttgtgataatttatgtgtgag gcaaa tttgtccacgttctttaattttgttatagtagatatcaaatccaatggagctacagttcttggcttaaacagatatagt ttttctg gaacgaattctacaacattattataaaggactttgggtagataagtgggatgaaatcctattttaattaatgcgatagc ctt gtcctcgtgcagatatccaaacgcttttgtgatagtatggcattcattgtctagaaacgctctacgaatatctgtgaca gat atcatctttagagaatatactagtcgcgttaatagtactacaatttgtattttttaatctatctcaataaaaaaattaa tatgtat gattcaatgtataactaaactactaactgttattgataactagaatcagaatctaatgatgacgtaaccaagaagttta tc tactgccaatttagctgcattatttttagcatctcgtttagattttccatctgccttatcgaatactcttccgtcgata tctacaca ggcataaaatgtaggagagttactaggccccactgattcaatacgaaaagaccaatctctcttagttatttggcagtac t cattaataatggtgacagggttagcatctttccaatcaataatttttttagccggaataacatcatcaaaagacttatg atc ctctctcattgatttttcgcgggatacatcatctattatggcgtcagccataacatcagcatccggcttatccgcctcc gttgt cataaaccaacgaggaggaatatcgtcggagctgtacaccatagcactacgttgaagatcgtacagagctttattaa cttctcgcttctccatattaagttgtctagttagttgtgcagcagtagctccttcgattccaatgtttttaatagccgc acacac aatctctgcgtcagaacgctcgtcaatatagatcttagacatttttagagagaactaacacaaccagcaataaaacta atttattttatcatttttttattcatcatcctctggtggttcgtcgtttctatcgaatgtggatctgattaacccgtca tctataggtg atgctggttctggagattctggaggagatggattattatctggaagaatctctgttatttccttgttttcatgtatcga ttgcgtt gtaacattaagattgcgaaatgctctaaatttgggaggcttaaagtgttgtttgcaatctctacacgcatgtctaacta gtg gaggttcgtcagcggctctagtttgaatcatcatcggcgtagtattcctacttttacagttaggacacggtgtattgta tttct cgtcgagaacgttaaaataatcgttgtaactcacatcctttattttatctatattgtattctactcctttcttaatgca ttttatacc gaataagagatagcgaaggaattclitttcggtgccgctagtacccttaatcatatcacatagtgttttatattccaaa tttgt ggcaatagacggtttatttctatacgatagtttgtttctggaatcctttgagtattctataccaatattattctttgat tcgaattta gtttcttcgatattagattttgtattacctatattcttgatgtagtactttgatgatttttccatggcccattctatta agtcttccaag ttggcatcatccacatattgtgatagtaattctcggatatcagtagcggctaccgccattgatgtttglicattggatg agta actactaatgtatacattliccatttataacacttatgtattaactttgttcatttatattttttcattattatgttga tattaacaaaa gtgaatatatatgttaataattgtattgtggttatacggctacaatttcataatgagtggaagtcagtgtccgatgatc aatg acgatagctttactctgaaaagaaagtatcaaatcgatagtgcggagtcaacaataaaaatggataagaagaggat aaagtttcagaatagagccaaaatggtaaaagaaataaatcagacaataagagcagcacaaactcattacgaga cattgaaactaggatacataaaatttaagagaatgattaggactactactctagaagatatagcaccatctattccaaa taatcagaaaacttataaactattctcggacatttcagccatcggcaaagcatcacagaatccgagtaagatggtatat gctctgctgctttacatgtttcccaatttgtttggagatgatcatagattcattcgttatagaatgcatccaatgagta aaatc aaacacaagatcttctctcctttcaaacttaatcttattagaatattagtggaagaaagattctataataatgaatgca gat ctaataaatggagaataattggaacacaagttgataaaatgttgatagctgaatctgataaatatacaatagatgcaa ggtataacctaaaacccatgtatagaatcaagggaaaatctgaagaagataccctctttatcaaacagatggtagaa caatgtgtgacatcccaggaattggtggaaaaagtgttgaagatactgtttagagatttgttcaagagtggagaataca aagcgtacagatacgatgatgatgtagaaaatggatttattggattggatacactaaaattaaacattgttcatgatat a gttgaaccatgtatgcctgttcgtaggccagtggctaagatactgtgtaaagaaatggtaaataaatactttgagaatc c gctacatattattggtaaaaatcttcaagagtgcattgactttgttagtgaataggcatttcatctttctccaatacta attcaa attgttaaattaataatggatagtataaatagttattagtgataaaatagtaaaaataattattagaataagagtgtag tat catagataactctcttctataaaaatggattttattcgtagaaagtatcttatatacacagtagaaaataatatagatt tttta aaggatgatacattaagtaaagtaaacaattttaccctcaatcatgtactagctctcaagtatctagttagcaattlic ctc aacacgttattactaaggatgtattagctaataccaatttttttgttttcatacatatggtacgatgttgtaaagtgta cgaag cggttttacgacacgcatttgatgcacccacgttgtacgttaaagcattgactaagaattatttatcgtttagtaacgc aat acaatcgtacaaggaaaccgtgcataaactaacacaagatgaaaaatttttagaggttgccgaatacatggacgaa ttaggagaacttataggcgtaaattatgacttagttcttaatccattatttcacggaggggaacccatcaaagatatgg a aatcatttttttaaaactgtttaagaaaacagacttcaaagttgttaaaaaattaagtgttataagattacttatttgg gctta cctaagcaagaaagatacaggcatagagtttgcggataatgatagacaagatatatacactctatttcaacaaactg gtagaatagtccatagcaatctaacagaaacgtttagagattatatctttcccggagataagactagctattgggtgtg g ttaaacgaaagtatagctaatgatgcggatattgttcttaatagacacgccattaccatgtatgataaaattcttagtt atat atactctgagataaaacaaggacgcgttaataaaaacatgcttaagttagtttatatctttgagcctgaaaaagatatc a gagaacttctgctagaaatcatatatgatattcctggagatatcctatctattattgatgcaaaaaacgacgattggaa a aaatattttattagtttttataaagctaattttattaacggtaatacatttattagtgatagaacgtttaacgaggact tattcag agttgttglicaaatagatcccgaatatttcgataatgaacgaattatgtctttattctctacgagtgctgcggacatt aaac gatttgatgagttagatattaataacagttatatatctaatataatttatgaggtgaacgatatcacattagatacaat ggat gatatgaagaagtgtcaaatctttaacgaggatacgtcgtattatgttaaggaatacaatacatacctgtttttgcacg ag tcggatcccatggtcatagagaacggaatactaaagaaactgtcatctataaaatccaagagtagacggctgaactt gtttagcaaaaacattttaaaatattatttagacggacaattggctcgtctaggtcttgtgttagatgattataaagga gact tgttagttaaaatgataaaccatcttaagtctgtggaggatgtatccgcattcgttcgattttctacagataaaaaccc tagt attcttccatcgctaatcaaaactattttagctagttataatatttccatcatcgtcttatttcaaaggtttttgagag ataatcta tatcatgtagaagaattcttggataaaagcatccatctaaccaagacggataagaaatatatacttcaattgataagac acggtagatcatagaacagaccaaatatattattaataatttgtatatacatagatataattatcacacatttttgata aatg ggaactgctgcaacaattcagactcccaccaaattaatgaataaagaaaatgcagaaatgattttggaaaaaattgtt gatcatatagttatgtatattagtgacgaatcaagtgattcagaaaataatcctgaatatattgattttcgtaacagat acg aagactatagatctctcattataaaaagtgatcacgagtttgtaaagctatgtaaaaatcatgcagagaaaagttctcc agaaacgcaacaaatgattatcaaacacatatacgaacaatatcttattccagtatctgaagtactattaaaacctata atgtccatgggtgacataattacatataacggatgtaaagacaatgaatggatgctagaacaactctctaccctaaact ttaacaatctccgcacatggaactcatgtagcataggcaatgtaacgcgtctglittatacattttttagttatctgat gaaa gataaactaaatatataagtataatcccattctaatactttaacctgatgtattacctgcatcttattagaatattaac ctaac taaaagacataacatagttgataaaaagcggtaggatataaatattatggctgccaccgttccgcglittgacgacgtg tacaaaaatgcacaaagaagaattctagatcaagaaacattttttagtagaggtctaagtagaccgttaatgaaaaac acatatctatttgataattacgcgtatggatggataccagaaactgcaatttggagtagtagatacgcaaacttagatg c aagtgactattatcccatttcgttgggattacttaaaaagttcgagtttctcatgtctctatataaaggtcctattccc gtatat gaagaaaaagtaaatactgaattcattgctaatggatcgttctctggtagatacgtatcatatcttcgaaagttttctg ccct tccaacaaacgagtttattagttttttgttactgacttccattccaatctataatatcttgttctggtttaaaaatact cagtttgat attactaaacacacattattcagatacgtctatacagataatgccaaacacctggcgttggctaggtatatgcatcaaa caggagactataagcctttgtttagtcgtctcaaagagaattatatatttaccggtcccgttccaataagtatcaaaga tat agatcaccctaatcttagtagagcaagaagtccatccgattatgagacattagctaatattagtactatattgtacttt acc aagtatgatccggtattaatgtttttattgttttacgtacctgggtattcaattactacaaaaattactccagccgtag aatatc taatggataaactgaatctaacaaagagcgacgtacaactgttgtaaattattttatgcttcgtaaaatgtagglittg aac caaacattctttcaaagaatgagatgcataaaactttattatccaatagattgactatttcggacgtcaatcgtttaaa gta aacttcgtaaaatattctttgatcactgccgagtttaaaacttctatcgataattgtttcatatgttttaatatttaca agtlitttg gtccatggtacattagccggacaaatatatgcaaaataatatcgttctccaagttctatagtttctggattatttttat tatattc agtaaccaaatacatattagggttatctgcggatttataatttgagtgatgcattcgactcaacataaataattctaga gg agacgatctactatcaaattcggatcgtaaatctgtttctaaagaacggagaatatctatacatacctgattagaattc at ccgtccttcagacaacatctcagacagtctggtcttgtatgtcttaatcatattcttatgaaacttggaaacatctctt ctagtt tcactagtacctttattaattctctcaggtacagattttgaattcgacgatgctgagtatttcatcgttgtatatttct tcttcgatt gcataatcagattcttatataccgcctcaaactctattttaaaattattaaacaatactctattattaatcagtcgttc taactc tttcgctatttctatagacttatcgacatcttgactgtctatctctgtaaacacggagtcggtatctccatacacgcta cgaa aacgaaatctgtaatctataggcaacgatgttttcacaatcggattaatatctctatcgtccatataaaatggattact taat ggattggcaaaccgtaacataccgttagataactctgctccatttagtaccgattctagatacaagatcattctacgtc ct atggatgtgcaactcttagccgaagcgtatgagtatagagcactatttctaaatcccatcagaccatatactgagttgg c tactatcttgtacgtatattgcatggaatcatagatggcclittcagttgaactggtagcctgttttagcatcttttta tatctggc tctctctgccaaaaatgttcttaatagtctaggaatggttccttctatcgatctatcgaaaattgctatttcagagatg aggtt cggtagtctaggttcacaatgaaccgtaatatatctaggaggtggatatttctgaagcaagagctgattatttatttct tctt ccaatctattggtactaacaacgacaccgactaatgtttccggagatagatttccaaagatacacacattaggataca gactgttataatcaaagattaatacattattactaaacattttttgttttggagcaaataccttaccgccttcataagg aaact tttgttttgtlictgatctaactaagatagttttagtttccaacaatagctttaacagtggacccttgatgactgtact cgctctat attcgaataccatggattgaggaagcacatatgttgacgcacccgcgtctgtttttgtttctactccataatactccca caa atactgacacaaacaagcatcatgaatacagtatctagccatatctaaagctatgtttagattataatccttatacatc tg agctaaatcaacgtcatcctttccgaaagataatttatatgtatcattaggtaaagtaggacatgatagtacgacttta aa tccattttcccaaatatctttacgaattactttacatataatatcctcatcaacagtcacataattacctgtggttaaa accttt gcaaatgcagcggctttgcctttcgcgtccgtagtatcgtcaccgatgaacgtcatttctctaactcctctatttaata cttta cccatgcaactgaacgcgttcttggatatagaatccaatttgtacgaatccaatttttcagatlittgaatgaatgaat atag atcgaaaaatatagttccattattgttattaacgtgaaacgtagtattggccatgccgcctactcccttatgactagac tga tttctctcataaatacagagatgtacagcttcctttttgtccggagatctaaagataatcttctctcctgttaataact ctagac gattagtaatatatctcagatcaaagttatgtccgttaaaggtaacgacgtagtcgaacgttagttccaacaattglit ag ctattcgtaacaaaactatttcagaacatagaactagttctcgttcgtaatccatttccattagtgactgtatcctcaa acat cctctatcgacggcttcttgtatttcctgttccgttaacatctcttcattaatgagcgtaaacaataatcgtttaccac ttaaat cgatataacagtaacttgtatgcgagattgggttaataaatacagaaggaaacttcttatcgaagtgacactctatatc t agaaataagtacgatcttgggatatcgaatctaggtatttttttagcgaaacagttacgtggatcgtcacaatgataac at ccattgttaatctttgtcaaatattgctcgtccaacgagtaacatccgtctggagatatcccgttagaaatataaaacc aa ctaatattgagaaattcatccatggtggcattttgtatgctgcgtttctttggctcttctatcaaccacatatctgcga cggag cattttctatctttaatatctagattataacttattgtctcgtcaatgtctatagttctcatctttcccaacggcctcg cattaaatg gaggaggagacaatgactgatatatttcgtccgtaactacgtaataaaagtaatgaggaaatcgtataaatacggtct cgccatttcgacatctggatttcagatataaaaatctglittcaccgtgactttcaaaccaattaatgcaccgaacatc cat ttatagaatttagaaatatattttcatttaaatgaatcccaaacattggggaagagccgtatggaccattatttttata gtact ttcgcaagcgggtttagacggcaacatagaagcgtgtaaacgaaaactatatactatagtcagcactcttccatgtcct gcatgtagacggcacgcgactatcgctatagaggacaataatgtcatgtctagcgatgatctgaattatatttattatt tttt catcagattatttaacaatttggcatctgatcccaaatacgcgatcgatgtgacaaaggttaaccctttataaacttaa cc cattataaaacttatgattagtcacgactgaaataaccgcgtgattattttttggtataattctacacggcatggtlic tgtaa ctatgaattcaacccccgttacattagtgaaatctttaacaaacagcaagggttcgtcaaagacataaaactcattgtt t acaatcgaaatagaccccctatcacacttaaaataaaaaatatccttatcctttaccaccaaataaaattctgattggt c aatgtgaatgtattcacttaacagttccacaaatttatttattaactccgaggcacatacatcgtcggtattttttatg gcaaa ctttactcttccagcatccgtttctaaaaaaatattaacgagttccatttatatcatccaatattattgaaatgacgtt gatgg acagatgatacaaataagaaggtacggtacctttgtccaccatctcctccaattcatgctctattttgtcattaacttt aatgt atgaaaacagtacgccacatgcttccatgacagtgtgtaacactttggatacaaaatgtttgacattagtataattgtc ca agactgtcaatctataatagatagtagctataatatattctatgatggtattgaagaagatgacaatcttggcatattg atc atttaacacagacatggtatcaacagatagcttgaatgaaagagaatcagtaattggaataagcgtclictcgataga gtgtccgtataccaacatgtctgatattttgatgtattccattaaattatttaglittttctttttattctcgttaaac agcatttctgtc aacggaccccaacatcgttgaccgattaagttttgattgatttttccgtgtaaggcgtatctagtcagatcgtatagcc tat ccaataatccatcatctgtgcgtagatcacatcgtacactttttaattctctatagaagagcgacagacagcaatttct ttat tctctacagatgtaagatacttgaagacattcctatgatgatgcagaattttggataacacggtattgatggtatctgt tac cataattcctttgatggctgatagtgtcagagcacaagatttccaatctttgttttgatatctatatcagacagcatgg tgcgt ctgacaacacaaggattaagacggaaagatgaaatgattctctcaacatcttcaatggataccttgctattttttctgg ca ttatctatatgtgcgagaatatcctctagagaatcagtatcctttttgatgatagtggatctcaatgacatgggacgtc taa acclicttattctatcaccagattgcatggtgatttgtcttctttcttttatcataatgtaatctctaaattcatcggc aaattgtct atatctaaaatcataatatgagatgtttacctctacaaatatctgttcgtccaatgttagagtatctacatcagttttg tattcc aaattaaacatggcaacggatttaattttatattcctctattaagtcctcgtcgataataacagaatgtagataatcat ttaa tccatcgtacatggttggaagatgcttgttgacaaaatctttaattgtcttgatgaaggtgggactatatctaacatct tgatt aataaaatttataacattgtccataggatactttgtaactagttttatacacatctcttcatcggtaagtttagacaga atatc gtgaacaggtggtatattatattcatcagatatacgaagaacaatgtccaaatctatattgtttaatatattatataga tgta gcgtagctcctacaggaatatclitaactaagtcaatgatttcatcaaccgttagatctattttaaagttaatcatata ggca ttgatttttaaaaggtatgtagccttgactacattctcattaattaaccattccaagtcactgtgtgtaagaagattat attcta tcataagcttgactacatttggtcccgataccattaaagaattcttatgatataaggaaacagattttaggtactcatc tact ctacaagaattttggagagccttaacgatatcagtgacgtttattatttcaggaggaaagaatctaacattgagaatat c ggaattaatagcttccagatacagtgattttggcaatagtccgtgtaatccataatccagtaacacgagctggtgcttg ct agacaccttttcaatgtttaatttttttgaaataagctttgataaagccttcctcgcaaattccggatacatgaacatg tcgg cgacatgattaagtattglittttcattattttctcaacaagttctcaataccccaatagatgatagaatatcacccaa tgcgt ccatgttgtctatttccaacaggtcgctatatccaccaatagaagtttttccaaaaaagattctaggaacagttctacc ac cagtaatttgttcaaaatagtcacgcaattcattttcgggtttaaattctttaatatcgacaatttcatacgctcctct tttgaaa ctaaacttatttagaatatccagtgcatttctacaaaaaggacatgtatacttgacaaaaattgtcactttgttattgg ccaa cctttgttgtacaaattcctcggccattttaatatttaagtgatataaaactatctcgacttatttaactctttagtcg agatatat ggacgcagatagctatatgatagccaactacagaaggcaaacgctataaaaaacataattacgacgagcatatttat aaatatttttattcagcattacttgatatagtaatattaggcacagtcaaacattcaaccactctcgatacattaactc tctc attttctttaacaaattctacaatatcttcgtaaaaagattcttgaaactttttagaatatctatcgactctagatgaa atagc gttcgtcaacatactatgttttgtatacataaaggcgcccattttaacagtttctagtgacaaaatgctagcgatccta gga tcctttagaatcacatagattgacgattcgtctctcttagtaactctagtaaaataatcatacaatctagtacgcgaaa taa tattatccttgacttgaggagatctaaacaatctaglittgagaacatcgataagttcatcgggaatgacatacatact atc tttaatagaactcttttcatccagttgaatggattcgtccttaaccaactgattaatgagatcttctattttatcattt tccagatg atatgtatgtccattaaagttaaattgtgtagcgcttctttttagtctagcagccaatactttaacatcactaatatcg atatac aaaggagatgatttatctatggtattaagaattcgtttttcgacatctgtcaaaaccaattcctttttgcctgtatcat ccagttt tccatcctttgtaaagaaattattttctactagactattaataagactgataaggattcctccataattgcacaatcca aact ttttaacaaaactagactttacaagatctacaggaatgcgtaattcaggtttcttagcttgtgattttttcttttgtgg acattttc ttgtgaccaactcatctaccatttcattgattttagcagtgaaataagctttcaatgcacgggcactgatactattgaa aac gagttgatcttcaaattccgccatttaagttcaccaaacaacttttaaatacaaatatatcaatagtagtagaataaga ac tataaaaaaaataataattaaccaataccaaccccaacaaccggtattattagttgatgtgactgttttctcatcactt ag aacagatttaacaatttctataaagtctgtcaaatcatcttccggagaccccataaatacaccaaatatagcggcgtac aacttatccatttatacattgaatattggcttttctttatcgctatcttcatcatattcatcatcaatatcaacaagtc ccagatta cgagccagatclicttctacattttcagtcattgatacacgttcactatctccagagagtccgataacgttagccacca ctt ctctatcaatgattagtttcttgagtgcgaatgtaatttttgtttccgttccggatctatagaagacgataggtgtgat aattgc cttggccaattgtctttctcttttactgagtgattctagttcaccttctatagatctgagaatggatgattctccagtc gaaaca tattctaccatggatccgtttaatttgttgatgaagatggattcatccttaaatgttttctctgtaatagtttccaccg aaagact atgcaaagaatttggaatgcgttccttgtgcttaatglitccatagacggcttctagaagttgatacaacataggacta gc cgcggtaacttttatttttagaaagtatccatcgcttctatcttgtttagatttatttttataaagtttagtctctcct tccaacataa taaaagtggaagtcatttgactagataaactatcagtaagttttatagagatagacgaacaattagcgtattgagaagc atttagtgtaacgtattcgatacattttgcattagatttactaatcgattttgcatactctataacacccgcacaagtc tgtag agaatcgctagatgcagtaggtcttggtgaagtttcaactctcttcttgattaccttactcatgattaaacctaaataa ttgta ctttgtaatataatgatatatattttcactttatctcatttgagaataaaaatgtttttgtttaaccactgcatgatgt acagatttc ggaatcgcaaaccaccagtggttttattttatccttgtccaatgtgaattgaatgggagcggatgcgggtttcgtacgt ag atagtacattcccgtttttagaccgagactccatccgtaaaaatgcatactcgttagtttggaataactcggatctgct ata tggatattcatagattgactttgatcgatgaaggctcccctgtctgcagccatttttatgatcgtcttttgtggaattt cccaaa tagttttataaactcgcttaatatcttctggaaggtttgtattctgaatggatccaccatctgccataatcctattctt gatctca tcattccataattttctctcggttaaaactctaaggagatgcggattaactacttgaaattctccagacaatactctcc gagt gtaaatattactggtatacggttccaccgactcattatttcccaaaatttgagcagttgatgcagtcggcataggtgcc ac caataaactatttctaagaccgtatgttctgattttatcttttagaggttcccaattccaaagatccgacggtacaaca ttcc aaagatcatattgtagaataccgttactggcgtacgatcctacatatgtatcgtatggtccttccttctcagctagttc acaa ctcgcctctaatgcaccgtaataaatggtttcgaagatcttcttatttagatcttgtgcttccaggctatcaaatggat aattt aagagaataaacgcgtccgctaatccttgaacaccaataccgataggtctatgtctcttattagagatttcagcttctg g aataggataataattaatatctataattttattgagatttctgacaattactttgaccacatccttcagtttgagaaaa tcaaa tcgcccatctattacaaacatgttcaaggcaacagatgccagattacaaacggctacctcattagcatccgcatattgt attatctcagtgcaaagattactacacttgatagttcctaaattttgttgattactctttttgttacacgcatccttat aaagaat gaatggagtaccagtttcaatctgagattctataatcgctttccagacgactcgagcctttattatagatttgtatctc ctttct ctttcg tatagtg tataca atcgttcg a actcgtctccccaaacattgtccaatccag g acattcatccg g aca catcaac gaccactctccgtcatccttcactcgtttcataaagagatcaggaatccaaagagctataaatagatctctggttctat gtt cctcgtttcctgtattctttttaagatcgaggaacgccataatatcagaatgccacggttccaagtatatggccataac tcc aggccgtttgtttcctccctgatctatgtatctagcggtgttattataaactctcaacattggaataataccgtttgat atacc attggtaccggagatatagcttccactggcacgaatattactaattgatagacctattccccctgccattttagagatt aat g cg catcgttttaacgtgtcatag ataccctctatg ctatcatcgatcatg ttaagtagaaaacagctagacatttggtg a cgactagttcccgcattaaataaggtaggagaagcgtgcgtaaaccatttttcagaaagtagattgtacgtctcaatag ctg agtctatatcccattg atg aattccta ctg cg a cacg catta acatgtg ctg a g gtctttcaa cg atcttgttgtttattttc aacaagtaggatttliccaaagttttaaaaccaaaatagttgtatgaaaagtctcgttcgtaaataataaccgagttga gt ttatccttatatttgttaactatatccatggtgatacttg aaataatcggagaatg tttcccatttttaggattaacatagttg aa taaatcctccatcacttcactaaatagtttttttgtttccttgtgtagatttgatacggctattctggcggctagaatg gcataat ccggatgttgtgtagtacaagtggctgctatttcggctgccagagtgtccaattctaccgttgttactccattatatat tccttg aataaccttcatagctattttaataggatctatatgatccgtgtttaagccataacataattttctaatacgagacgtg atttt atcaaacatgacattttccttgtatccatttcgtttaatgacaaacatttttgttggtgtaataaaaaaaattatttaa cttttcat taatagggatttgacgtatgtagcgtacaaaattatcgttcctggtatatagataaagagtcctatatatttgaaaatc gtta cggctcgattaaactttaatgattgcatagtgaatatatcattaggatttaactccttgactatcatggcggcgccaga aat taccatcaaaagcattaatacagttatgccgatcgcagttagaacggttatagcatccaccatttatatctaaaaatta g atcaaagaatatgtgacaaagtcctagttgtatactgagaattgacgaaacaatgtttcttacatattttttttttatt agtaac cgacttaatagtaggaactggaaaactagacttgattattctataagtatagatacccttccaaataatattctctttg ata aaagttccagaaaatgtagaattttttaaaaagttatcttttgctattaccaagattgtgtttagacgcttattattaa tatgag tg atg aaatccaca ccg cctcta g atatcg cttttatttccacattag atg gtaaatccaatag tg aaactatctttttag g a atgtatggactcgcgtttagaggagtgaacgtcttaggcgtcggaaaggggccggcctttttttctagacactaaataa a tagtaagattaaattaattataaaattatgtatataatattaattataaaattatgtatatgatttactaactttagtt agataaa ttaataatacataaattttagtatattaatattataaattaataatacataaattttagtatattaatattatatttta aatatttattt agtgtctagaaaaaaaggcctagcaggcc

[0071] Any of the sequences of the sMVA fragments F1, F2, and F3 may contain one or more alterations or variations. For example, the sequence of sMVA
fragment F1 (deposited at NCB! under Accession No. MW023923, www.ncbi.nlm.nih.gov/nuccore/MW023923.1/) contains 1 nucleotide alteration in a non-coding determining region downstream of open reading frame 021 (SEQ ID NO:

12):

[0072]
ggcctagcaggccggccttlitttctagacactaaataaatagtaagattaaattaattataaaattat gtatataatattaattataaaattatgtatatgatttactaactttagttagataaattaataatacataaattttagt atattaat attataaattaataatacataaattttagtatattaatattatattttaaatatttatttagtgtctagaaaaaaatgt gtgacca acgaccgtaggaaactctagagggtaagaaaaatcaatcgctttatagagaccatcagaaagaggtttaatatlittgt gagaccatcgaaggagaaagagataaaacttttttacgactccatcagaaagaggtttaatattlitgtgagaccatcg aagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagaga aagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaa acttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaaacttttttac ga ctccatcagaaagaggtttaatattlitgtgagaccatcgaaggagaaagagataaaacttttttacgactccatcaga aagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagaggttt a atatttttgtgagaccatcgaaggagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgt gag accatcgaagagagaaagagaataaaaatattttagtgacaccatcagaaagaggtttaatatttttgtgagaccatc gaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaaggaga aagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataa aactlitttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaactttttt ac gactccatcagaaagaccatcgaagagagaaagagaaagagatagttagtctagatatlittcttagtacaaaagtc aatgttttaaaatatatggacaagaatttgtctgtataaaaacttgtgtgaaattttgtaccaaagaaaaaatgtgagc ag tatcccctacatggattttactagatcatttatataccaaaaaatattatacgatctacgttttattatatgattttaa cgtgtaa attataaacattattttatgatatacaattgtctggtaacctagatgggcataggggatgagtatatgttgttggacgt tattg tttaagaaatagttgatgcatcagaaagagglitaatatttttgtgagaccatcgaagagagaaagagataaaactttt tt acgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttatgactcca t tgaagagagaatgagaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagaccatcaaaga gagaaagagaataaaaatattttatgactccattgaagagagaaagagaaaatgagaataaaaatattttagtgaca ccatcagaaagaggtttaatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaacttttt tta tgagaccatcaaagagagaaagagaataaaaatattthgtaaaactlittttatgagaccatcaaagagagaaaga gaataaaaatatttttgtaaaactthtttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaacttt tttt atgagaccatcaaagagagaaagagaataaaaatatlittgtaaaacttlitttatgagaccatcaaagagagaaag agaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaact tttt ttatgagaccatcaaagagagaaagagaataaaaatattttatgactccattgaagagagaaagagaataaaaata ttttagtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagaataaaaatattttatg a ctccattgaagagagaaagagaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagaccat c aaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaat atttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgag accat caaagagagaaagagaataaaaatatttttgtaaaacttlitttatgagaccatcaaagagagaaagagaataaaaa tatttttgtaaaactthtttatgagaccatcaaagagagaaagagaataaaaatattttatgactccattgaagagaga a tgagaataaaaatattttagtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagaa taaaaatattttatgactccattgaagagagaaagagaataaaaatattttagtgacaccatcagaaagaggtttaata thtttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagaga aagagaataaaaatatttttgtaaaactttlittatgagaccatcaaagagagaaagagaataaaaatatttttgtaaa a ctttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagag ag aaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaa a actttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaaga ga gaaagagaataaaaatattttatgactccattgaagagagaatgagaataaaaatattttagtgacaccatcagaaa gagglitaatatttttgtgagaccatcgaagagagaaagagaataaaaatattttatgactccattgaagagagaatga gaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagaccatcaaagagagaaagagaata aaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaaattataaa cat tattttatgatatacaattgtctggtaacctagatgggcataggggatgttgataagctcgacgagtatatgttgttgg acgt tattgtttaagaaatagttgatgcatcagaaagagaataaaaaatattttagtgagaccatcgaagagagaaagagat aaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaactlit tt acgactccatcagaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaaactthttacgactccatc agaaagaggtttaatatttttgtgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatga ga ccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaata aaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaacttttttt atgag accatcaaagagagaaagagaataaaaatattttatgactccattgaagagagaatgagaataaaaatattttagtg acaccatcagaaagaggtttaatattlitgtgagaccatcgaagagagaaagagaataaaaatattttatgactccatt gaagagagaatgagaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagaccatcaaaga gagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttg t aaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaa ag agagaaagagaataaaaatatlittgtaaaactttttttatgagaccatcaaagagagaaagagaataaaaatatttta t gactccattgaagagagaatgagaataaaaatattttagtgacaccatcagaaagaggtttaatattthgtgagaccat cgaagagagaaagagaataaaaatattttatgactccattgaagagagaaagagaataaaaatattttagtgacac catcagaaagaggtttaatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttt tat gagaccatcaaagagagaaagagaataaaaatattttatgactccattgaagagagaatgagaataaaaatatttta gtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagaataaaaatattttatgactcc attgaagagagaatgagaataaaaatattttagtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaag agagaaagagaataaaaatattttatgactccattgaagagagaatgagaataaaaatattttagtgacaccatcag aaagaggtttaatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgag acc atcaaagagagaaagagaataaaaatatttttgtaaaactttttttatgagaccatcaaagagagaaagagaataaa aatatttttgtaaaactttlittatgagaccatcaaagagagaaagagaataaaaatatttttgtgagaccatcaaaga g agaaagagaataaaaatattlitgtgagaccatcaaagagagaaagagaataaaaatatttttgtgagaccatcaaa gagagaaagagaataaaaatattttatgactccattgaagagagaaagagaataaaaatattttagtgacaccatca gaaagaggtttaatatttttgtgagaccatcgaagagagaaagagaataaaaatattttatgactccattgaagagag aaagagaataaaaatattttagtgacaccatcagaaagaggtttaatattttttatgagaccatcaaagagagaaaga gaataaaaatattttttatgagaccatcaaagagagaaagagaataaaaatattttatgagaccatcaaagagagaa agagaataaaaatatttlitatgagaccatcaaagagagaaagagaataaaaatattttatgagaccatcaaagaga gaaagagaataaaaatattttttatgagaccatcaaagagagaaagagaataaaaatatttttgtatgagaccatcag aaagaggtttaatatttttgtgataccctgaaaggaaataggaatagtgtcataatcgtatcacactattgagacagaa a aagaagaagtcgcgagaggtaacttlitgttttgcaaaccggaatatagtgtccggtacacttttttaattcgtggtgt gcc tgaatcgttcgattaaccctactcatccaatttcagatgaatagagttatcgattcagacacacgctttgagttttgtt gaat cgatgagtgaagtatcatcggttgcaccttcagatgccgatccgtcgacatacttgacctcaagttcagatgattcctt gc acatgtctccgatacgaacgctaaactctagattcttgacacattttgtatcgacgatcgttgaaccgatgatatcttc gta actcactttcttatgagagatgttagacccgagtactggatgggtcttgatgtcgctgtctttctcttcttcgctacat ctgatgt cgatagacacctcacagtclitccatcagcggattctgagatggatttaatctgaggacatttggtgaatccaaagttc at tctcagacctccaccgatgatggagtaataagtggtaggaggatctacatcctcgactgattccacctcgggatctgga tctgactcggactctgtaatttccgttacggattggcaaatcttatcatcggtcggtgtttggtcttgctttgtgactt tgataat aacatcgattcccatatgatgthgttttcttcttccgtacacgatgaggatgattgctgaagactggcaggcacatgca tg ccagtacgatatattgtttcatgattgctattgattgagtactgttctttatgattctacttccttaccgtgcaataaa ttagaata tattttctacttttacgagaaattaattattgtatttatgggtgaaaaacttactataaaaagcgggtggglitggaat tagtg atcagtttatgtatatcgcaactaccgggcatatggctacattacccacatgataagagattgtatcagtttcgtagtc ttg agtattggtattactatatagtatatagatgtcgacgctagagttactgtctccgaatgcggcatgatagtatcattct ttgct ttcgttaactgtttggaggaagaatctttgttattgcatttaatctcgaaattcagagtgcacacctttctcctgtaaa gaaac ctgaagtcgctaccttattaagaagacgggatcgcagtctttatgattcatagtaatagttagttccgacgttgagatg ga ttcgctgagaccggtagtggtcgtccgagtacacgatgtgtcgttaactggatacaggttaatttccacatcgatatag tt aaaggtatttctgggtacgggttcgcatttatctgcggaagagacggtgtgagaatatgttccgagaccacacggaga acagatgacgtctccggatactccgtatcctattccacattttgtttgggaaacacatgccttgcatccatgatcggga ga gcattcacagattctattgtgagtcgtgttacacgatcgcgtcgacattgttgacagaaacgtgaccttcattcttacc gtc gtccataaatacgttaggtatgtaccacatactgtcgcgaacgatgcgtccatctcataatgatttactttttcataat taaa gatgtgaaagaaaaccgaacaatatatttttttagtaatgtttatgcgagacatataaaataaactccgtgtttatgat gcc ggtaaatgtttttatcatcttggacggaatcgattttgtaatatgccatggaaacaggacattatcactccatgataaa ttat ttaatggagtcgatcctctcattgttctttgcgtatctcaatctgtggcgtttgcttcgtttaaataatatatcaaaca tggaga cgcctgatatgtaggcattcttcattctattaatgtctgctctatagcgctttagttccttatgacgaccggcgatatc atactt actttagaaggaaaatcatcatctaggattaaggcgtatctgatacaggcgaataatggttcaggatatagatagcgta tatctctattaaatgcgtcaatcatagtctctagagtgggatggtaactcagtaataaatcaactagcttctctttggt aact gcttttctggatggccgtattgattatcgagcgtgacactcgctccatattccaataaccgctttgcaaattgtatatt attga catcgaccgcgtaatatagtagagttatcgatcatatctatatcatccatgtacttgcttagtatatcaaatacatctt cata acagtgatacccgcaattattaaatctcgataatatcagaccgtacatacatagacggccattgttagatatgtgattt ac agccgcgtgtccatattttccacgataaaccttacgacgtttacatcgacgagattattattaacaaagttgttgtccg tcgt cttatccaacatgcattgaatgataggtatacttaccatatcgccgtaatgtaagtagtttatcagtatggcttgtacg atgg attcatcctgttgtctaaatctctttagaatgttatcgatgatgtagtggttatattctctggaatcgtacgaagtaat actacg cattacgtcgacaagagtatgacgtctctcaataagaagattaacgatttccatgtctacattatatggggttactcta aat cgcligtttagataatacgcctctaatatagggctgacgtcgtatactctacacgtgtccacatcctttattaataatc tctat atctatggttgagcaagaccagtagtattggatggaaacattgttatcgatcaaacatttaattacatccttggataga ga ttctctatgagacgatatatagtaatgaagagagttcttacacatatcactgttgtacatacaggtacgaaatacgtaa cc ggtgctgtaacattctgatttaagaagccatagcaatacttctggtctcggattaggcgtcgttacgtatatatccacc aat ccgagaccattgattgcataattcgtattcttggacggacgtatccgtttatccacaattaggtattttagcagacgta agt cgaaatcatttatattcgacttgagttcgttagaggaattcgaatagctggatatcagtagatgcacaatctgagattt tac gtatctatgcttactgtatgctcctagcggagttaatccttcgttgtttctacaaagtctctcgactccgcgagagagt aaca gtcgaacaatcttaatgtctgtatcgcatttattggagacgtaacaatgtagcgcattgtttcctcgtctatctatatg ttttgat aagttgtgacacgtttcaatttctagttttatttttttgtacgtcacatcttcatccagtagacgacatagaatacatg tgcaat ccatagctattctggtgctaattattcctcataagatgataaaaagtgtagtgagagagcatgaaggagatttagtatt ta gcagtgcggatatgatccaagagggtgagatagtcgttctcgttcagaatctttcgcagcataagtagtatgtcgatat a cttatcgttgaagactcttccagagacgatagctgattgagtacaaagtccaatgattgcacgaagttcttcggcggtt tt catggagtcatttctgatgaaacatttaatgatctaaatttcagtttatgtttgtaccccgtattcatacttaacaaat tggtatt acataccattaataatgcaagcataaaaaatcgttagtagatgtttctaaatataggttccgtaagcaaagaatataag aatgaagcggtaatgataaaatcaatcgttatctaaaatgatcatactcatttattttattctattatattaacacata cattttt aacagcaacacattcaatattgtattgttatttttatattatttacacaattaacaatatattattagtttatattact gaattaata atataaaattcccaatcttgtcataaacacacactgagaaacagcataaacacaaaatccatcaaaaatgttgataa attatctgatgttgttgttcgctgctatgataatcagatcattcgccgatagtggtaacgctatcgaaacgacatcgcc ag aaattacaaacgctacaacagatattccagctatcagattatgcggtccagagggagatggatattgtttacacggtga ctgtatccacgctagagatatcgacggtatgtattgtagatgctctcatggttatacaggcattagatgtcagcatgta gta ttagtagactatcaacgttcagaaaaaccaaacactacaacgtcatatatcccatctcccggtattatgcttgtattag ta ggcattattattattacgtgttgtctattatctgtttataggttcactcgacgaactaaactacctatacaagatatgg ttgtgc cataattlitataaattthtttatgagtatttttacaaaaatgtataaagtgtatgtcttatgtatatttataaaaatg ctaaatatg cgatgtatctatgttatttgtatttatctaaacaatacctctacctctagatattatacaaaaattttttatttcggca tattaaag taaaatctagttaccttgaaaatgaatacagtgggtggttccgtatcaccagtaagaacataatagtcgaatacagtat ccgattgagattttgcatacaatactagtctagaaagaaatttgtaatcatcttctgtgacgggagtccatatatctgt atca tcgtcccatgctatattcctgttatcatcattagttaatgaaaataactctcgtgcttcagaaaagtcaaatattgtat ccata catacatctccaaaactatcgcttatacgtttatctttaacgatacctatacctagatggttatttactaacagacatt ttcca gatctattgactataactcctatagtttccacatcaaccaagtaatgatcatctattgttatataacaataacataact ctttt ccgtttttatcagtatgtatatctatatcaacgtcgtcgttgtagtgaatagtagtcattgatctattatatgaaacgg atatgt ctagaacggcaattgttttacgtccagttaacactttcgttgatttaaagtctagagtctttgcaaacataatatcctt atccg actttatatttcctgtagggtggtataattttattttgcctccacatatcggtgtttccaaatatattactagacaata ttccatat agttattagttaagggtacccaattagaacacgtacgcttattatcatcatttggatcgtatttcataaaagttattgt actat cgatgtcaacacattctacattttttaatcgtctatatagtatttttctgatattttctataatatcagaattgtcttc catcggaag ttgtatactatcggaatcagttacatgtttaaataattctctgatgtcattccttatacaatcaaattcattattaaac agtttaa tagtctgtagacctttatcgtcgtaaatatccattgtcttattagttacgcttatttttatgtgtttttacgttgcttt attatattttata agaatgattgtttgacgaatcacgagaactattaagacacattattaggtatatattataaaaaagtttttgattacga tgtt ataagaggaaagaggacacattaacatcatacatcaattaactacattcttataacatcgtaatcaaaagaattgcaa ttttgatgtataacaactgtcaatgggttatggaattgtatattacatattatacggtatgttggtaacgacaaatacc gatc ggtaattgtctgccggtgtaatagaattatatatatctatctattacaccggccttgtatacataataataagttgtgg tagta tgatctccatatttataatttaggactttgtattcagtttttttggaatcataaaaaataaaaaaaagttttactaatt taaaatt atttacatttttttcactgtttagtcgcggatatggaattcgatcctgccaaaatcaatacatcatctatagatcatgt aacaa tattacaatacatagatgaaccaaatgatataagactaacagtatgcattatcacaaaaataaatccacatttggctaa tcaatttcgggcttggaaaaaacgtatcgccggaagggactatatgactaacttatctagagatacaggaatacaaca atcaaaacttactgaaactgtcaaaaaaatagaaacatatatggtctatatatacactacaatttagttattaattgga ta accgatgtgattatcaatcaatattaagaaggttggtaaattggtacatagctaataatacctatacacccaataatac a acaaccatttctgagttggatatcatcaaaatactggataaatacgaggacgtgtatagagtaagtaaagaaaaaga atgtgaaatttgctatgaagttgtttactcaaaacgatagatactttggtttattggattcgtgtaatcatatattttg cataaca tgcatcaatatatggcatagaacacgaagagaaaccggtgcgtcggataattgtcctatatgtcgtacccgttttagaa acataacaatgagcaagttaactaataaataaaaagtttaatttgttgacgacgtatgtcgttattttttctcgtataa aaga ttaatttgattctaatataatctttagtattggataaatatcaattcaaattaattccattagattatatcataaataa aaatagt agcacgcactacttcagccaaatattcttttttgaaacgccatctatcgtagtgaggacacaagtgaacctataatgag c aaatttattagtatcggttacatgaaggactttacgtagagtggtgattccactatctgtggtacgaacggtttcatct tcttt gatgccatcacccagatgttctataaacttggtatcctttgccaaccaatacatatagctaaactcaggcatatgttcc ac acatcctgaacaatgaaattctccagaagatgttacaatgtctagatttggacatttggtttcaaccgcgttaacatat ga gtgaacacacccatacatgaaagcgatgagaaataggattttcatcttgccaaaatatcactagaaaaaatttatttat c aattttaaaggtataaaaaatacttattgttgctcgaatattttgtatttgatggtatacggaagattagaaatgtagg tattat catcaactgattctatggttttatgtattctatcatgtttcactattgcgttggaaataatatcatatgcttccacata tattttatttt gttttaactcataatactcacgtaattctggattattgacatatctatgaataattttagctccatgatcagtaaatat taatga gaacatagtattaccacctaccattatttttttcatctcattcaattcttaattgcaaagatctatataatcattatag cgttgac ttatggactctggaatcttagacgatgtacagtcatctataatcatggcatatttaatacattglittatagcatagtc gttatc tacgatgttagatatttctctcaatgaatcaatcacacaatctaatgtagglitatgacataatagcattlicagcagt tcaat gtttttagattcgttgatggcaatggctatacatgtatatccgttatttgatctaatgttgacatctgaaccggattct agcagt aaagatactagagattglitattatatctaacagccligtgaagaagtglitctcctcgtttgtcaatcatgttaatgt clitaa gataaggtaggcaaatglltatagtactaagaattgggcaagcataagacatgtcacaaagaccctlittgtatgtata a gtgtaaaaattataacattcatagttggatttacataggtgtccaatcgggatctctccatcatcgagataattgatgg cat ctcccttccttlittagtagatatttcatcgtgtaagaatcaatattaatatttctaaagtatccgtgtatagcctcli tatttacca cagttccatattccactagagggatatcgccgaatgtcatatactcaattagtatatgliggaggacatccgagttcat tgt tlicaatatcaaaaagatgglitccttatcatttctccatagtggtacaatactacacattattccgtgcggclitcca ttlicca aaaacaatttgaccaaatctacatclitattgtatctataatcactatttagataatcagccataattactcgagtgca acat gttagatcgtctatatatgaataagccgtgttatctattcctlicattaacaatttaacgatgtctatatctatatgag atgactt aatataatattgaagagctgtacaatagtlittatctataaaagacggcttgattccgtgattaattagacatttaaca actt ccggacgcacatatgctctcgtatccgactctgaatacagatgagagatgatatacagatgcaatacggtaccgcaat ttcgtagttgataatcatcatacgcgtatcagtactcgtcctcataaagaacactgcagccattttctatgaacaaatc aat aatttcaggaacaggatcatctgtcattacataattlictataactgaacgatgglittcacatttaacactcaagtca aatc catglictaccaacacctttatcaagtcaacgtctacattlitggatttcatatagctgaatatattaaagtcatttat gligcta aatccagtggclictagtagagccatcgctatatcctttaactttaacatgtctactatttgtgtattclictaatggg gtagct gtctccaattlitgcgtaatggattagtgccactgtctagtagtagtttgacgacctcgacattattacaatgctcatt aaaa aggtatgcgtgtaaagcattattcttgaattgglicctggtatcattaggatctctgtctctcaacatctglitaagtt catcga gagccacctcctcattttccaaatagtcaaacattttgactgaatgagctactgtgaactctatacacccacacaacta a tgtcattaaatatcatgtcaaaaacttgtacaattattaataaaaataatttagtglitaaattttaccagttccagat tttaca cctccgttaaccccactlittacaccactggacgatcctcctccccacattccaccgccaccagatgtataaglittag at cctttattactaccatcatgtccatggataaagacactccacatgccgccactaccccctttagaagacatattaataa g acttaaggacaagtttaacaataaaattaatcacgagtaccctactaccaacctacactattatatgattataglitct attt ttacagtaccttaactaaagtctctagtcacaagagcaatactaccaacctacactattatatgattatagtlictatt litat aggaacgcgtacgagaaaatcaaatgtctaatttctaacggtagtgttgataaacgattatcgtcaatggatacctcct c tatcatgtcgtctattlicttactttglictattaacttattagcattatatattatttgattataaaacttatattgc ttattagcccaa tctgtaaatatcggattattaacatatcgtlictligtaggiltatttaacatgtacatcactgtaagcatgtccgtac catttattt taatttgacgcatatccgcaatttctlittcgcagtcggttataaattctatatatgatggatacatgctacatgtgta cttataa tcgactaatatgaagtacttgatacatattttcagtaacgatttattattaccacctatgaataagtacctgtgatcgt ctagg taatcaactglittcttaatacattcgatggliggtaatttactcagaataatttccaatatcttaatatataattctg ctatttctg ggatatatttatctgccagtataacacaaatagtaatacatgtaaacccatattttgttattatattaatgtctgcgcc attatc tattaaccattctactaggctgacactatgcgacttaatacaatgataaagtatactacatccatgtttatatcatcaa tata cggcttacaaaglittagtatcgataacacatccaactcacgcatagagaaggtagggaataatggcataatatttatt aggttatcatcattgtcattatctacaactaagtttccattttttaaaatatactcgacaactttaggatctctattgc caaatttt tgaaaatatttatttatatgcttaaatctatataatgtagctccttcatcaatcatacatttaataacattgatgtata ctgtatg ataagatacatattctaacaatagatcttgtatagaatctgtatatcttttaagaattgtggatattattacgtaaact attaca caattctaaaatataaaacgtatcacggtcgaataatagttgatcaactatataattatcgattttgtgatttttcttc ctaaa ctgtttacgtaaatagttagatagaatattcattagttcatgaccactatagttactatcgaataacgcgtcaaatatt tccc gtttaatatcgcatttgtcaagataataatagagtgtggtatgttcacgataagtataataacgcatctctttttcgtg tgaaa ttaaatagtttattacgtccaaagatgtagcataaccatcttgtgacctagtaataatataataatagagaactgtttt acc cattctatcatcataatcagtggtgtagtcgtaatcgtaattgtctaattcatcatcccaattataatattcaccagca cgtct aatctgttctattttgatcttgtatccatactgtatgttgctacatgtaggtattcctttatccaataatagtttaaac acatctac attgggatttgatgligtagcgtatttttctacaatattaataccatttttgatactatttatttctatacctttcgaa attagtaattt caataagtctatatcgatgttatcagaacatagatattcgagtatatcaaaatcattgatatttttatagtcgactgac gac aataacaaaatcacaacatcgtttttgatattattatttttcttggtaacgtatgcctttaatggagtttcaccatcat actcata taatggatttgcaccactttctatcaatgattgtgcactgctggcatcgatgttaaatgttttacaactatcatagagt atctta tcgttaaccatgattggttgttgatgctatcgcattttttggtttctttcatttcagttatgtatggatttagcacgtt tgggaagca tgagctcatatgatttcagtactgtagtgtcagtactattagtttcaataagatcaatctctagatctatagaatcaaa acac gataggtcagaagataatgaatatctgtaggcttcttgttgtactgtaacttctcglittgttagatgtttgcatcgtg ctttaac atcaatggtacaaattttatcctcgctttgtgtatcatattcgtccctactataaaattgtatattcagattatcatga gatgtgt atacgctaacggtatcaataaacggagcacaccatttagtcataaccgtaatccaaaaatttttaaagtatatcttaac g aaagaagttgtgtcattgtctacggtgtatggtactagatcctcataagtgtatatatctagagtaatgtttaatttat caaat ggttgataatatggatcctcatgacaatttccgaagatggaaatgagatatagacatgcaataaatctaattgcggaca tggttactccttaaaaaaatacgaataatcaccttggctatttagtaagtgtcatttaacactatactcatattaatcc atgg actcataatctctatacgggattaacggatglictatatacggggatgagtagttttcttctttaactttatacttttt actaatca tatttagactgatgtatgggtaatagtglitaaagagttcgttctcatcatcagaataaatcaatatctctgttlittt gttataca gatgtattacagcctcatatattacgtaatagaacgtgtcatctaccttattaactttcaccgcatagttgtttgcaaa tacg gttaatcctttgacctcgtcgatttccgaccaatctgggcgtataatgaatctaaactttaatttcttgtaatcattcg aaata atttttagtttgcatccgtagttatcccctttatgtaactgtaaatttctcaacgcgatatctccattaataatgatgt cgaattc gtgctgtatacccatactgaatggatgaacgaataccgacggcgttaatagtaatttactttttcatclitacatattg ggta ctagttttactatcataagtttataaattccacaagctactatggaataagccaaccatcttagtataacacacatgtc tta aagtttattaattaattacatgttgttttatatatcgctacgaatttaaacagagaaatcagtttaggaaaaaaaaata tcta tctacatcatcacgtctctgtattctacgatagagtgctactttaagatgagacatatccgtgtcatcaaaaatatact ccat taaaatgattattccggcagcgaacttgatattggatatatcacaacctttgttaatatctacgacaatagacagcagt cc catggttccataaacagtgagtttatctttctttgaagagatattttgtagagatcttataaaactgtcgaatgacatc gcatt tatatctttagctaaatcgtatatgttaccatcgtaatatctaaccgcgtctatcttaaacgtttccatcgctttaaag acgtttc cgatagatggtctcatttcatcagtcatactgagccaacaaatataatcgtgtataacatctttgatagaatcagactc ta aagaaaacgaatcggctttattatacgcattcatgataaacttaatgaaaaatgtttttcgttgtttaagttggatgaa tagt atgtcttaataattgttattatttcattaattaatatttagtaacgagtacactctataaaaacgagaatgacataact agttat caaagtgtctaggacgcgtaattttcatatggtatagatcctgtaagcattgtctgtattctggagctattttctctat atctaat ttctgaacgttcaccaatgtctctagccactttggcactaatagcgatcattcgcttagcgtcttctatattattaact ggttga ttcaatctatctagcaatggaccgtcggacagcgtcattctcatgttcttaatcaatgtacatacatcgccgtcatcta cca attcatccaacaacataagclitttaaaatcatcattataataggtttgatcgttgtcatttctccaaagaatatatct aataa gtagagtcctcatgattagttaacaactattttttatgttaaatcaattagtacaccgctatgtttaatacttattcat attttagtt tttaggattgagaatcaatacaaaaattaatgcatcattaattttagaaatacttagtttccacgtagtcaatgaaaca tttg aactcatcgtacaggacgttctcgtacaggacgtaactataaaccggtttatatttgttcaagatagatacaaatccga t aactlittttacgaattctacgggatccactttaaaagtgtcataccgggttctttttatttttttaaacagattaatg gtgtgatg ttgattaggtcttttacgaatttgatatagaatagcgtttacatattctccataatggtcaatcgccatttgttcgtat gtcataa attctttaattatatgacactgtgtattatttagttcatccttgttcatcattaggaatctatccaatatggcaattat actagaac tataggtgcgttgtatacacatattgatgtgtctgtttatacaatccatgctactaccttcgggtaaaattgtagcatc atata ccatttctagtactttaggttcattgttatccattgcagaggacgtcatgaacgcatcctaaaaaaatatattattttt atgttat tttgttaaaaataatcatcgaatacgaatcatccagtccactgaatagcaaaatctttactattttggtatcttccaat gtgg ctgcctgatgtaatggaaattcattctctagaagatttttcaatgctccagcgttcaacaacgtacatactagacgcac gtt attatcagctattgcataatacaaggcactatgtccatggacatccgccttaaatgcatctttgctagagagaaagctt tt cagctgcttagacttccaagtattaattcgtgacagatccatgtctgaaacgagacgctaattagtgtataatttttgt cata ttgcaccagaattaataatatctctaatagatctgattagtagatacatggctatcgcaaaacaacatatacacattta at aaaaataatatttattaagaaaattcagatttcacgtacccatcaatataaataaaataatgattccttacaccgtacc ca tattaaggagattctaccttacccataaacaatataaatccagtaatatcatgtctgatgatgaacacaaatggtgtat ta aattccagttlitcaggagatgatctcgccgtagctaccataatagtagatgcctctgctacagttccttgttcgtcga catc tatctttgcattctgaaacattttataaatatataatgggtccctagtcatatgtttaaacgacgcattatctggatta aacat actaggagccatcatttcggctatcgacttaatatccctcttattttcgatagaaaatttagggagtttaagattgtac acttt attccctaattgaaacgaccaatagtctaattttgcagccgtaatagaatctgtgaaatgggtcatattatcacctatt gcc aggtacatactaatattagcatccttatacggaaggcgtaccatgtcatattctttgtcatcgattgtgattgtatttc cttgca atttagtaactacgttcatcatgggaaccgttlicgtaccgtacttattagtaaaactagcattgcgtgttttagtgat atcaa acggatattgccatatacctttaaaatatatagtattaatgattgcccatagagtattattgtcgagcatattagaatc tact acattagacataccggatctacgttctactatagaattaattttattaaccgcatctcgtctaaagtttaatctatata ggcc gaatctatgatattgttgataatacgacggtttaatacacacagtattatctacgaaactttgataagttagatcagtg tac gtatatttagatgttttcagcttagctaatcctgatattaattctgtaaatgctggacccagatctclitttctcaaat ccatagt cttcaataattctattctagtattacctgatgcaggcaatagcgacataaacatagaaaacgaataaccaaacggtga gaagacaatattatcatcttgaatatlittatacgctactataccggcattggtaaatccligtagacgataggtagac gct gaacacgttaacgatagtatcaataacgcaatcatgattttatggtattaataattaaccttatttttatgttcggtat aaaaa ttattgatgtctacacatcclittgtaattgacatctatatatcclittgtataatcaactctaatcactttaactlit acaglittccc taccagtttatccctatattcaacatatctatccatatgcatcttaacactctctgccaagatagcttcagagtgagga tagt caaaaagataaatatatagagcataatcattctcgtatactctgccctttattacatcgcccgcattgggcaacgaata a caaaatgcaagcatcligttaacgggctcgtaaattgggataaaaattatglitttatatctattttattcaagagaat attca ggaatttctlittccggligtatctcatcgcagtatatatcatttgtacattglitcatattlittaatagtttacacc littagtagga ctagtatcgtacaattcatagctgtattttgaattccaatcacgcataaaaatatclictaattgttgacgaagaccta atcc atcatccggtgtaatattaatagatgctccacatgtatccgtaaagtaatttcctgtccaatttgaggtacctatatag gcc glittatcggttaccatatatttggcatgglitaccctagaatacggaatgggaggatcagcatctggtacaataaata gc tttacttctatatttatglitttagattttagcatagcgatagatcttaaaaagtlictcatgataaacgaagatcgtt gccagc aactaatcaatagcttaacggatacttgtctgtctatagcggatclicttaattcatclictatataaggccaaaacaa aatt ttacccgccttcgaataaataatagggataaagttcataacagatacataaacgaatttactcgcatttctaatacatg a caataaagcggttaaatcattgglictliccatagtacatagttgttgcggtgcagaagcaataaatacagagtgtgga a caccacttacgttaatactaagaggatgatctgtattataatacgacggataaaagtlittccaattatatggtagatt gtta actccaagataccagtatacctcaaaaatttgagtgagatccgctgccaagttcctattattgaagatcgcaataccca attclitgacctgagttagtgatctccaatccatgttagcgcttcctaaataaatatgtgtattatcagatatccaaaa ttligt atgaagaactcctcctaggatatttgtaatatctatgtatcgtacttcaactccggccatttgtagtclitcaacatcc tttaat ggtttgttagatttattgacggctactctaactcgtactcctclittgggtaattgtacaatctcgtttaatattatcg tgccgaa attcgtacccacttcatccgataaactccaataaaaagatgatatatctagtglitttgtggtattggatagaatttcc ctcc acatgttaaatgtagacaaatatactttatcaaattgcatacctataggaatagtctctgtaatcactgcgattgtatt atcc ggattcattttatttgttaaaagaataatcctatatcacttcactctattaaaaatccaagtlictatttclitcatga ctgattlitt aacttcatccgtttccttatgaagatgatglitggcaccttcataaattlitatttctctattacaatttgcatgttgc atgaaata atatgcacctaaaacatcgctaatctcattglitgliccctggagtatgagagtcggggtgttaatcliggaaattatt tlicta accttgliggtagccttcaagacctgactagcaaatccagccttaattlittcatgattgattaatgggtcgtattggt atttat aaactttatccatatctctagatactgattctggacatagclitccgactggcgcatttggtgtgatgglicccataag tttgg cagctagcagattcagtcttgaaacagcatctgcattaactagaggagacattagaatcattgctgtaaacaagtttgg attatcgtaagaggctagtatagaaattgttgctcccatggaatgacccaataagtagatttaatagttaccacgtgct gt accaaagtcatcaatcatcattlittcaccattacttcliccatgtccaatatgatcatgtgagaatactaaaattcct aacg atgatatglittcagctagttcgtcataacgtccagaatglitaccagctccatgacttatgaatactaatgccttagg atat gtaatcattgtccagattgaacatacagtttgcactcatgattcacgttatataactatcaatattaacagttcgtttg atgat catattattlitatglittattgataattgtaaaaacatacaattaaatcaatatagaggaaggagacggctactgtcl ittgt gagatagtcatggcgactaaattagattatgaggatgctglittttactligtggatgatgataaaatatgtagtcgcg actc catcatcgatctaatagatgaatatattacgtggagaaatcatgttatagtglitaacaaagatattaccagligtgga ag actgtacaaggaattgatgaagttcgatgatgtcgctatacggtactatggtattgataaaattaatgagattgtcgaa gc tatgagcgaaggagaccactacatcaattttacaaaagtccatgatcaggaaagtttattcgctaccataggaatatgt gctaaaatcactgaacattggggatacaaaaagatttcagaatctagattccaatcattgggaaacattacagatctg atgaccgacgataatataaacatcttgatactttttctagaaaaaaaattgaattgatgatataggggtcttcataacg ca taattattacgttagcattctatatccgtgttaaaaaaaattatcctatcatgtatttgagagttttatatgtagcaaa catgat agctgtgatgccaataagctttagatattcacgcgtgctagtgttagggatggtattatctggtggtgaaatgtccgtt atat aatctacaaaacaatcatcgcatatagtatgcgatagtagagtaaacatttttatagthttactggattcatacatcgt cta cccaattcggttatgaatgaaattgtcgccaatcttacacccaaccccttgttatccattagtatagtattaacttcgt tattta tgtcataaactgtaaatgattttgtagatgccatatcatacatgatattcatgtccctattataatcattactaacttt atcaca atatatgttgataatatctatatatgatctagtctttgtgggcaactgtctatacaagtcgtctaaacgttgtttactc atatagt atcgaacagccatcattacatggtcccgttccgttgatagataatcgagtatgttagtggacttgtcaaatctatatac cat attttctggaagtggatatacatagtcgtgatcaacattattgctagcctcatcttctatatcctgtactataccatct acata atctacgatattattacacataaacatcgacaacatactattgtttattatctaagtcctgttgatccaaacccttgat ctcct ctatttgtactatctagagattgtacttcttccagttctggataatatatacgttgatagattagctgagctattctat ctccagt atttacattaaacgtacattttccattattaataagaatgactcctatgtttcccctataatcttcgtctattacacca cctccta tatcaatgccttttagtgacagaccagacctaggagctattctaccatagcaaatcttaggcatggacatactaatatc t gtcttaattaactgtctttctcctggagggatagtataatcgtaagcgctatacaaatcatatccggcagcacccggcg at tgcctagtaggagatttagctctgttagtttccttaacaaatctaactggtgagttaatattcatgttgaacataaaac taat attttatttcaaaattatttaccatcccatatattccatgaataagtgtgatgattgtacacttctatagtatctatat acgattca cgataaaatcctcctatcaatagcagtttattatccactatgatcaattctggattatccctcggataaataggatcat ctat cagagtccatgtattgctggattcacaataaaattccgcatttctaccaaccaagaataacclictaccgaacactaac gcgcatgatttataatgaggataataagtggatggtccaaactgccactgatcatgattgggtagcaaatattctgtag tt gtatcagtttcagaatgtcctcccattacgtatataacattgtttatggatgccactgctggattacatctagglitca gaag actcggcatattaacccaagcagcatccccgtggaaccaacgctcaacagatgtgggatttggtagacctcctactac gtataatttattgttagcgggtatcccgctagcatacagtctggggctattcatcggaggaattggaatccaattgttt gat atataatttacagctatagcattgttatgtatttcattgttcatccatccaccgatgagatatactacttctccaacat gagta cttgtacacatatggaatatatctataatttgatccatgttcataggatactctatgaatggatacttgtatgatttgc gtggtt gtttatcacaatgaaatattttggtacagtctagtatccattttacattatttatacctctgggagaaagataatttga cctgat tacatttttgataaggagtagcagatttcctaatttatttcttcgctttatataccacttaatgacaaaatcctcatct ggaaca tttagttcatcgctttctagaataagtttcatagatagataatcaaaattgtctatgatgtcatcttccagttccaaaa agtgtt tggcaataaagtttttagtatgacataagagattggatagtccgtattctatacccatcatgtaacactcgacacaata ttc ctttctaaaatctcgtaggataaagtttatacaagtgtagatgataaattctacagaggttaatatagaagcacgtaat aa attgacgacgttatgactatctatatatacctttccagtatatgagtaaataactatagaagttagactgtgaatgtca agg tctagacaaaccctcgtaactggatctttatttttcgtgtatlittgacgtaaatgtgtgcgaaagtaaggagataact ttttc aatatcgtagaattgactattatattgcctcctatggcatcaataattgttttgaatttcttagtcatagacaatgcta atatatt cttacagtacacagtattgacaaatatcggcatttatgtttctttaaaagtcaacatctaaagaaaaatgattatcttc ttga gacataactcccattttttggtattcacccacacgtttttcgaaaaaattagttttaccttctaatgatatattttcca tgaaatc aaacggattggtaacattataaatttttttaaatcccaattcagaaatcaatctatccgcgacgaattctatatatgtt ttcat catttcacaattcattcctataagtttaactggaagagccgcagtaagaaattcligttcaatggataccgcatctgtt ata atagatctaacggtttcttcactcggtggatgcaataaatgtttaaacatcaaacatgcgaagtcgcagtgtagaccct c gtctctactaatcaattcgttggaaaacgtgagtccgggcattaggccacgctttttaagccaaaatatggaagcgaat gatccggaaaagaagattccttctactgcagcaaaggcaataagtctctctccataaccggcgctgtcatgtatccact tttgagcccaatcggccttcttttttacacaaggcatcgtttctatggcattaaagagataglittlitcattactatc tttaacat aagtatcgatcaaaagactatacatttccgaatgaatgttttcaatggccatctgaaatccgtagaaacatctagcctc g gtaatctgtacttctgtacaaaatcgttccgccaaattttcattcactattccgtcactggctgcaaaaaacgccaata cat gttttataaaatatttttcgtctggtgttagtttattccaatcattgatatctttagatatatctacttcttccactgt ccaaaatgat gcctctgcclitttatacatgttccagatgtcatgatattggattgggaaaataacaaatctatttggatttggtgcaa ggat gggttccataactaaattaacaataacaataaatttlitttcagttatctatatgcctgtacttggatcttttgtacat cgatatc gccgcaatcactacaataattacaagtattattgatagcattgttattagtactatcataattaaattatcgttattat cattttg taattgtgacatcatactagataaatcgtttgcgagattgttgtgggaagcgggcatggaggatgaattatcgttatta tta tttaaagcctcccattcggattcacaaatatggcgcgcgttcaacattttatggaaacagataacaagaaaactcgtca tcgttcaaatlittaacgatagtaaaccgattaaacgtcgagctaatttctaacgctagcgactctgliggatatgggt ttcc agatatatatcttttcagttcccctacgtatctataatcatctgtaggaaatggaagatatttccatttatctactgtt cctaata tcatatgtggtggtgtagtagaaccattaagcgcgaaagatgttatttcgcatcgtattttaacttcgcaataatttct ggtta gataacgcactctaccagtcaagtcaatgatattagcctttacagatatattcatagtagtcgtaacgatgactccatc ttt tagatgcgatactcctttgtatgtaccagaatcttcgtacctcaaactcgatatatttaaacaagttaatgagatatta acg cgttttatgaatgatgatatataaccagaagttttatcctcggtggctagcgctataaccttatcattataataccaac tagt gtgattaatatgtgacacgttagtgtgggtacaaatatgtacattatcgtctacgtcgtattcgatacatccgcataca gcc aacaaatataaaatgacaaatactctaacgccgttcgtacccatcttgatgcggtttaataaatgttttgatttcaatt tattg taaaaaaagattcggttttatactgttcgatattctcattgcttatattttcatctatcatctccacacagtcaaatcc gtggtta gcatgcacctcatcaaccggtaaaagactatcggactcttctatcattataactctagaatatttaatttggtcattat taat caagtcaattatcttatttttaacaaacgtgagtattttactcattttttataaaaacttttagaaatatacagactct atcgtgt gtctatatcttctttttatatccaatgtatttatgtctgatttttcttcatttatcatatataatggtccaaattctac acgtgcttcgg attcatccagatcattaaggttcttataattgtaacatccttctcttccctcttctacatcttccttcttattcttatt cttagcgtcac agaatctaccacagcaggatcccatgacgagcgtcatattaaactaatccattttcaattataatatacgattagtaat g accattaaaataaaaatattcttcataaccggcaagaaagtgaaaagttcacattgaaactatgtcagtagtatacatc atgaaatgatgatatatatatactctattttggtggaggattatatgatataattcgtggataatcattcttaagacac atttct tcattcgtaaatcttttcacgttaaatgagtgtccatattttgcaatttcttcatatgatggcggtgtacgtggacgag gctgct cctgttcttgligtagtcgccgactgtcgtgtctgcgtttagatccctccattatcgcgattgcgtagatggagtacta ttttata ccttgtaattaaatttttttattaattaaacgtataaaaacgttccgtatctgtatttaagagccagatttcgtctaat agaaca aatagctacagtaaaaataactagaataattgctacacccactagaaaccacggatcgtaatacggcaatcggttttc gataataggtggaacgtatattttatttaaggacttaacaattgtctgtaaaccacaatttgcttccgcggatcctgta ttaa ctatctgtaaaagcatatgttgaccgggcggagccgaacattctccgatatccaatttctgtatatctataatattatt aac ctccgcatacgcattacagttcttttctagcttggataccgcactaggtacatcgtctagatctattcctatttcctca gcgat agctcttctatccttttccggaagcaatgaaatcacttcaataaatgattcaaccatgagtgtgaaactaagtcgagaa tt actcatgcatttgttagttattcggagcgcgcaatttttaaactgtcctataacctctcctatatgaatagcacaagtg acat tagtagggatagaatgttgagctaatttttgtaaataactatctataaaaagattatacaaagttttaaactctttagt ttccg ccatttatccagtctgagaaaatgtctctcataataaatttttccaagaaactaattgggtgaagaatggaaaccttta atc tatatttatcacagtctgttttggtacacatgatgaattcttccaatgccgtactaaattcgatatctttttcgatttc tggatatgt ttttaataaagtatgaacaaagaaatggaaatcgtaataccagttatgtttaactttgaaattgttttttattttcttg ttaatgat tccagccacttgggaaaagtcaaagtcgtttaatgccgatttaatacgttcattaaaaacaaactttttatcctttaga tga attattattggttcattggaatcaaaaagtaagatattatcgggtttaagatctgcgtgtaaaaagttgtcgcagcatg gta gttcgtaaattttaatgtataacagagccatctgtaaaaagataaactttatgtattgtaccaaagatttaaatcctaa tttg atagctagctcggtatctactttatctgccgaatacagtgctaggggaaaaattataatatttcctctttcgtattcgt agtta gttctcttttcatgttcgaaaaagtgaaacatgcggttaaaatagtttataacattaatattactgttaataactgccg gata aaagtgggatagtaatttcacgaatttgatactgtcctttctctcgttaaacgcctttaaaaaaactttagaagaatat ctca atgatagttcctgaccatccatagtttgtatcaataatagcaacatatgaagaacacgtttatacagagtatgtaaaaa t gttaatttatagtttaatcccatggcccacgcacacacgattaattttttttcatctccctttagattgttgtatagaa atttgggt actgtgaactccgccgtagtttccatgggactatataattttgtggcctcgaatacaaattttactacatagttatcta tctta aagactataccatatcctcctgtagatatgtgataaaaatcgtcgtttataggataaaatcgtttatccttttgttgga aaaa ggatgaattaatgtaatcattctcttctatctttagtagtgtttccttattaaaattcttaaaataatttaacaatcta actgatgg agcccaattttggtgtaaatctaattgggacattatattgttaaaatacaaacagtctcctaatataacagtatctgat aat ctatggggagacatccattgatattcaggggatgaatcattggcaacacccatttattgtacaaaaagccccaatttac aaacgaaagtccaggtttgatagagacaaactattaactattttgtctctgtttttaatttctttggtaatgaaattat tcacaa tatcagtatcttctttatctaccagagattttactaacttgataaccttggctgtctcattcaatagggtagtaatatt tgtatgtg tgatattgatatcttttagaagtgattctttgatggtgccagcatacgaattacaataatgcagaaactcggttaacat gca ggaattatagtaagccaattccaattgttgcctgtgttgtattagagtgtcaatatgagcaatggtgtccttgcgtttc tctga tagaatgcgagcagcgattttggcgttatcatttgacgatatttctggaatgacgaatcctgtttctactaactttttg gtagg acaaagtgaaacaatcaagaagatagcttctcctcctatttgtggaagaaattgaactcctctagatgatctccttgac a gatattggaccgaattacagaagtacctggaatgtaaagccctgaaaccccctcattttttaagcagattgttgccgta a atcctgcactatgcccaagatagagagctcctttggtgaatccatctctatgtttcagtttaaccaagaaacagtcagc tg gtctaaaatttccatctctatctaatacagcatctaacttgatgtcaggaactatgaccggttatgttatatgtaacat tgagt aaatccttaagttcataatcatcactgtcatcagttatgtacgatccaaacaatgtttctactggcatagtggatacga ag atgctatccatcagaatgtttccctgattagtattttctatatagctattcttctttaaacgattttccaaatcagtaa ctatgttc atttttttaggagtaggacgcctagccagtatggaagaggattttctagatcctctcttcaacatctttgatctcaatg gaat gcaaaaccccatagtgtaacaaccaacgataaaaataatattgtttttcactttttataattttaccatctgactcatg gatt cattaatatclitataagagctactaacgtataattctttataactgaactgagatatatacaccggatctatggtttc cataa ttgagtaaatgaatgctcggcaataactaatggcaaatgtataaaacaacgaaattatactagagttgttaaagttaat attttctatgagctgttccaataaattatttgttgtaactgcgttcaagtcataaatcatcttgatactatccagtaaa ccgttttt aagttctggaatattattatcccattgtaaagcccctaattcgactatcgaatatcctgctctgatagcagtttcaata tcga cggacgtcaatactgtaataaaggtggtagtattgtcatcatcgtgataaactactggaatatggtcgttagtaggtac g gtaactttacacaacgcgatatataactttccttttgtaccatttttaacgtagttgggacgtcctgcagggtattgtt ttgaag aaatgatatcgagaacagatttgatacgatatttgttggattcctgattatttactataatataatctagacagataga tgat tcgataaatagagaaggtatatcgttggtaggataatacatccccattccagtattctcggatactctattaatgacac ta gttaagaacatgtcttctattctagaaaacgaaaacatcctacatggactcattaaaacttctaacgctcctgattgtg tct cgaatgcctcgtacaaggatttcaaggatgccatagattctttgaccaacgatttagaattgcgtttagcatctgattt tttta ttaaatcgaatggtcggctctctggtttgctaccccaatgataacaatagtcttgtaaagataaaccgcaagaaaattt at acgcatccatccaaataaccctagcaccatcggatgatattaatgtattattatagattttccatccacagttattggg cca gtatactgttagcaacggtatatcgaatagattactcatgtaacctactagaatgatagttcgtgtactagtcataata tctt taatccaatctaagaaatttaaaattagattttttacactgttaaagttaacaaaggtattacccggatacgtggatat cat atatggtattggtccattatcagtaatagctccataaactgatacggcgatggtttttatatgtgtttgatctaacgag gaag aaattcgcgcccacaattcatctctagatatgtatttaatatcaaacggtaacacatcaatttcgggacgcgtatatgt ttc taaatttttaatccaaatataatgatgacctatatgccctattatcatactgtcaactatagtacacctagagaactta cgat acatctgtttcctataatcgttaaattttacaaatctataacatgctaaacclittgacgacaaccattcattaatttc tgatat ggaatctgtattctcaataccgtatcgttctaaagccagtgctatatctccctgttcgtgagaacgclitcgtataata tcgat caacggataatctgaagtttttggagaataatatgactcatgatctatttcgtccataaacaatctagacataggaatt gg aggcgatgatcttaattttgtgcaatgagtcgtcaatcctataacttctaatattgtaatattcatcatcgacataaca ctatc tatgttatcatcgtatattagtataccatgaccttcttcatttcgtgccaaaatgatatacagtcttaaatagttacgc aatatc tcaatagtttcataattgttagctgttttcatcaaggtttgtatcctgtttaacatgatggcgttctatacgtttctat litttaaatttt taacgatttactgtggctagatacccaatctctctcaaatatttttttagcctcgcttacaagctgtttatctatacta ttaaaac tgacgaatccgtgattttggtaatgggttccgtcgaaatttgccgaagtgatatgaacatattcgtcgtcgactatcaa ca attttgtattattctgaatagtgaaaaccttcacagatagatcattttgaacacacaacgcgtctagacttctggcggt tgc catagaatatacgtcgttcttatcccaattaccaactagaagtctgatcttaactcctctattaatggctgcttctata atgga gttgtaaatgtcgggccaatagtagctattaccgtcgacacgtgtagtgggaactatggccaaatglicaatatctata ct agtcttagccgacttgagtttatcaataactacatcagtgtctagatctctagaatatcccaataggtgliccggagaa tc agtaaagaacactccacctataggattcttaatatgatacgcagtgctaactggcagacaacaagccgcagagcat aaattcaaccatgaattttttgcgctattaaaggctttaaaagtatcaaatcttctacgaagatctgtggccagcgggg ga taatcagaatatacacctaacgttttaatcgtatgtatagatcctccagtaaatgacgcgtttcctacataacatcttt catt atctgacacccaaaaacaaccgagtagtagtcccacattattttttttatctatattaacggttataaaatttatatcc gggc agtgactttgtagctctcccagatttcttttccctcgttcatctagcaaaactattattttaatccctttttcagatgc ctcttttagt ttatcaaaaataagcgctcccctagtcgtactcagaggattacaacaaaaagatgctatgtatatatatttcttagcta ga gtgataatttcgttaaaacattcaaatgttgttaaatgatcggatctaaaatccatattttctggtagtgtttctacca gcctac attttgctcccgcaggtaccggtgcaaatggccacatttagttaacataaaaacttatacatcctgttctatcaacgat tct agaatatcatcggctatatcgctaaaattttcatcaaagtcgacatcacaacctaactcagtcaatatattaagaagtt c catgatgtcatcttcgtctatttctatatccgtatccattgtagattgttgaccgattatcgagtttaaatcattacta atactca atccttcagaatacaatctgtgtttcattgtaaatttataggcggtgtatttaagttggtagattttcaattatgtatc aatatag caacagtagttcttgctcctccttgattctagcatcctcttcattattttcttctacgtacataaacatgtccaatacg ttagac aacacaccgacgatggcggccgccacagacacgaatatgactaaaccgatgaccatttaaaaacccctctctagct ttcacttaaactgtatcgattattcttttagaacatgtataatataaaaacattattctatttcgaatttaggcttcca aaaatttt tcatccgtaaaccgataataatatatatagacttgttaatagtcggaataaatagattaatgcttaaactatcatcatc tcc acgattagagatacaatatttacattttttttgctgtttcgaaactttatcaatacacgttaatacaaacccaggaagg aga tattgaaactgaggctgttgaaaatgaaacggtgaatacaataattcagataatgtaaaatcatgattccgtattctga tg atattagaactgctaatggatgtcgatggtatgtatctaggagtatctattttaacaaagcatcgatttgctaatatac aatt atcattttgattaattgttattttattcatattcttaaaaggthcatatttatcaattcttctacattaaaaatttcca tlittaatttatg tagccccgcaatactcctcattacgtttcatttlitgtctataatatccattttgttcatctcggtacatagattatcc aattgaga agcgcatttagtagttttgtacattttaagtttattgacgaatcgtcgaaaactagttatagttaacattttattattt gataccct gatattaatacccctgccgttactattatttataactgatgtaatccacgtaacattggaattaactatcgatagtaat gcat cgacgcttccaaaattgtctattataaactcaccgataatttttttattacatgttttcatattcattaggattattaa atctttaat cttactacgattgtatgcgttgatattgcaagacgtcattctaaaagacggaggatctccatcaaatgccagacaatca cgtacaaagtacatggaaataggttttgttctattgcgcatcatagatttatatagaacacccgtagaaatactaattt gttt tactctataaaatactaatgcatctatttcatcgttttgtataacgtctttccaagtgtcaaattccaaatttttttca ttgatagta ccaaattcttctatctctttaactacttgcatagataggtaattacagtgatgcctacatgccgttttttgaaactgaa tagat gcgtctagaagcgatgctacgctagtcacaatcaccactttcatatttagaatatatatatgtaaaaatatagtagaat ttc attttgttttttttctatgctataaatgaattctcattttgcatctgctcatactccgttttatatcaataccaaagaa ggaagatat ctggttctaaaagccgttaaagtatgcgatgttagaactgtagaatgcgaaggaagtaaagcttcctgcgtactcaaa gtagataaaccctcatcacccgcgtgtgagagaagaccttcgtccccttccagatgcgagagaatgaataacccag gaaaacaagttccgtttatgaggacggacatgctacaaaatatgttcgcggctaatcgcgataatgtagcttctagact t ttgtcctaaaatacaattatatccttttcgatattaataaatccgtgtcgtccaggthtttatctctttcagtatgtga atagata ggtattttatctctattcatcatcgaatttaagagatccgataaacattgtttgtattctccagatgtcagcatctgat acaac aatatatgtgcacataaacctctggcacttatttcatgtaccttccccttatcactaaggagaatagtatttgagaaat atgt atacatgatattatcatgaattagatatacagaatttgtaacactctcgaaatcacacgatgtgtcggcgttaagatct aa tatatcactcgataacacattttcatctagatacactagacattttttaaagctaaaatagtctttagtagtaacagta actat gcgattattttcatcgatgatacatttcatcggcatattattacgcttaccatcaaagactataccatgtgtatatcta acgta ttctagcatggttgccatacgcgcattaaactlitcaggatctttggatagatcttccaatctatctatttgagaaaac attttt atcatgttcaatagttgaaacgtcggatccactatatagatattatctataaagattttaggaactacgttcatggtat cctg gcgaatattaaaactatcaatgatatgattatcgttttcatcttttatcaccatatagtttctaagatatgggatttta cttaatat aatattatttcccgtaataaattttattagaaatgccaaatctataagaaaagtcctcgaattagtttgaagaatatct atat cgccgtaccgtatatttggattaattagatatagagaatatgatccgtaacatatacaacttttattatggcgtctaag atat tcttccatcaacttattaacattlitgactagggaagatacattatgacgtcccattacttttgccttgtctattactg cgacgtt catagaatttagcatatctcttgccaattcttccattgatgttacattataagaaattttagatgaaattacatttgga gcttta atagtaagaactcctaatatgtccgtgtatgtggtcactaatacagattgtagttctataatcgtaaataatttaccta tatta tatgtttgagtctglitagaaaagtagctaagtatacgatcttttatttctgatgcagatgtatcaacatcggaaaaaa atctt tttttattcttttttactaaagatacaaatatgtctttgttaaaaacagttattttctgaatatttctagcttgtaatt ttaacatatgat attcgttcacactaggtactctgcctaaataggtttctataatctttaatgtaatattaggaaaagtattctgatcagg attcct attcattttgaggatttaaaactctgattattgtctaatatggtctcaacacaaactttttcacagagcgatagagttt ttgata actcgtttttcttaagaaatataaaactactgtctccagagctcgctctatcttttattttatttaattcgatacaaac tcctgat actggttcagaaagtaattcattaattttcagtcctttatagaagatatttaatatagataatacaaaatclicagttt ttgatat cgatctgattgatcctagaactagatatattaataacgtgctcattaggcagtttatggcagcttgataattagatata gtat attccagttcatatttattagataccgcattgcccagattttgatattctatgaattcctctgaaaataaatccaaaat aacta gacattctattttttgtggattagtgtactctcttccctctatcatgttcactactggtgtccacgatgataaatatct agaggg aatataatatagtccataggatgccaatctagcaatgtcgaataactgtaattttattcttcgctcttcattatgaatt gattctt gaggtataaacctaacacaaattatattattagacttttcgtatgtaatgtctttcatgttataagtttttaatcctgg aataga atctattttaatgaggcttttaaacgcagagttctccaacgagtcaaagcataatactctgttggttttcttatatacg atgtta cgattttcttctttgaatggaataggtttttgaattagtttataattacaacataatagataaggaagtgtgcaaatag tacg cggaaaaaacataatagctcccctgttttcatccatggttttaagtaaatgatcactggcttctttagtcaatggatat tcga acattaaccgtttcatcatcattggacagaatccatatttcttaatgtaaagagtgatcaaatcattgtgtttattgta ccatct tgttgtaaatgtgtattcggttatcggatctgctcctttttctattaaagtatcgatgtcgatctcgtctaagaattca actatatc gacatatttcatttgtatacacataaccattactaacgtagaatgtataggaagagatgtaacgggaacagggtttgtt g attcgcaaactattctaatacataattclictgttaatacgtcttgcacgtaatctattatagatgccaagatatctat ataatt attttgtaagatgatgttaactatgtgatctatataagtagtgtaataattcatgtatttcgatatatgttccaactct gtctttgtg atgtctagtttcgtaatatctatagcatcctcaaaaaatatattcgcatatattcccaagtcttcagttctatcttcta aaaaat cttcaacgtatggaatataataatctattttacctcttctgatatcattaatgatatagtttttgacactatcttctgt caattgatt cttattcactatatctaagaaacggatagcgtccctaggacgaactactgccattaatatctctattatagcttctgga cat aattcatctattataccagaattaatgggaactattccgtatctatctaacatagttttaagaaagtcagaatctaaga cct gatgttcatatattggttcatacatgaaatgatctctattgatgatagtgactatttcattctctgaaaattggtaact cattcta tatatgctttccttgttgatgaaggatagaatatactcaatagaatttgtaccaacaaactgttctcttatgaatcgta tatca tcatctgaaataatcatgtaaggcatacatttaacaattagagacttgtctcctgttatcaatatactattcttgtgat aattta tgtgtgaggcaaatttgtccacgttctttaattttgttatagtagatatcaaatccaatggagctacagttcttggctt aaaca gatatagtttlictggaacgaattctacaacattattataaaggactttgggtagataagtgggatgaaatcctatttt aatt aatgcgatagccttgtcctcgtgcagatatccaaacgcttttgtgatagtatggcattcattgtctagaaacgctctac ga atatctgtgacagatatcatclitagagaatatactagtcgcgttaatagtactacaatttgtattttttaatctatct caataa aaaaattaatatgtatgattcaatgtataactaaactactaactgttattgataactagaatcagaatctaatgatgac gta accaagaagtttatctactgccaatttagctgcattatttttagcatctcgtttagattttccatctgccttatcgaat actcttcc gtcgatatctacacaggcataaaatgtaggagagttactaggccccactgattcaatacgaaaagaccaatctctctt agttatttggcagtactcattaataatggtgacagggttagcatctttccaatcaataatttttttagccggaataaca tcatc aaaagacttatgatcctctctcattgatlittcgcgggatacatcatctattatggcgtcagccataacatcagcatcc ggc ttatccgcctccgttgtcataaaccaacgaggaggaatatcgtcggagctgtacaccatagcactacgttgaagatcgt acagagctttattaacttctcgcttctccatattaagttgtctagttagttgtgcagcagtagctccttcgattccaat gthtta atagccgcacacacaatctctgcgtcagaacgctcgtcaatatagatcttagacattlitagagagaactaacacaac cagcaataaaactaatttattttatcatttttttattcatcatcctctggtggttcgtcgtttctatcgaatgtggatc tgattaacc cgtcatctataggtgatgctggttctggagattctggaggagatggattattatctggaagaatctctgttatttcctt gttttc atgtatcgattgcgttgtaacattaagattgcgaaatgctctaaatttgggaggcttaaagtgttgtttgcaatctcta cacg catgtctaactagtggaggttcgtcagcggctctagtttgaatcatcatcggcgtagtattcctacttttacagttagg aca cggtgtattgtatttctcgtcgagaacgttaaaataatcgttgtaactcacatcctttattttatctatattgtattct actcctttct taatgcattttataccgaataagagatagcgaaggaattctttttcggtgccgctagtacccttaatcatatcacatag tgtt ttatattccaaatttgtggcaatagacggtttatttctatacgatagtttgtttctggaatcctttgagtattctatac caatattat tctttgattcgaatttagtttcttcgatattagattttgtattacctatattcttgatgtagtactttgatgatttttc catggcccattct attaagtcttccaagttggcatcatccacatattgtgatagtaattctcggatatcagtagcggctaccgccattgatg tttg ttcattggatgagtaactactaatgtatacattttccatttataacacttatgtattaactttgttcatttatattttt tcattattatgtt gatattaacaaaagtgaatatatatgttaataattgtattgtggttatacggctacaatttcataatgagtggaagtca gtgt ccgatgatcaatgacgatagctttactctgaaaagaaagtatcaaatcgatagtgcggagtcaacaataaaaatgga taagaagaggataaagtttcagaatagagccaaaatggtaaaagaaataaatcagacaataagagcagcacaa actcattacgagacattgaaactaggatacataaaatttaagagaatgattaggactactactctagaagatatagca ccatctattccaaataatcagaaaacttataaactattctcggacatttcagccatcggcaaagcatcacagaatccga gtaagatggtatatgctctgctgctttacatgtttcccaatttgtttggagatgatcatagattcattcgttatagaat gcatcc aatgagtaaaatcaaacacaagatcttctctcctttcaaacttaatcttattagaatattagtggaagaaagattctat aat aatgaatgcagatctaataaatggagaataattggaacacaagttgataaaatgttgatagctgaatctgataaatata caatagatgcaaggtataacctaaaacccatgtatagaatcaagggaaaatctgaagaagataccctctttatcaaa cagatggtagaacaatgtgtgacatcccaggaattggtggaaaaagtgttgaagatactgtttagagatttglicaaga gtggagaatacaaagcgtacagatacgatgatgatgtagaaaatggatttattggattggatacactaaaattaaaca ttgttcatgatatagttgaaccatgtatgcctgttcgtaggccagtggctaagatactgtgtaaagaaatggtaaataa at actttgagaatccgctacatattattggtaaaaatcttcaagagtgcattgactttgttagtgaataggcatttcatct ttctcc aatactaattcaaattgttaaattaataatggatagtataaatagttattagtgataaaatagtaaaaataattattag aat aagagtgtagtatcatagataactctcttctataaaaatggattttattcgtagaaagtatcttatatacacagtagaa aat aatatagattttttaaaggatgatacattaagtaaagtaaacaattttaccctcaatcatgtactagctctcaagtatc tagt tagcaattttcctcaacacgttattactaaggatgtattagctaataccaatttttttgttttcatacatatggtacga tgttgta aagtgtacgaagcggttttacgacacgcatttgatgcacccacgttgtacgttaaagcattgactaagaattatttatc gtt tagtaacgcaatacaatcgtacaaggaaaccgtgcataaactaacacaagatgaaaaatttttagaggttgccgaat acatggacgaattaggagaacttataggcgtaaattatgacttagttcttaatccattatttcacggaggggaacccat c aaagatatggaaatcatttttttaaaactgtttaagaaaacagacttcaaagttgttaaaaaattaagtgttataagat tac ttatttgggcttacctaagcaagaaagatacaggcatagagtttgcggataatgatagacaagatatatacactctatt t caacaaactggtagaatagtccatagcaatctaacagaaacgtttagagattatatctttcccggagataagactagct attgggtgtggttaaacgaaagtatagctaatgatgcggatattgttcttaatagacacgccattaccatgtatgataa aa ttcttagttatatatactctgagataaaacaaggacgcgttaataaaaacatgcttaagttagtttatatctttgagcc tgaa aaagatatcagagaacttctgctagaaatcatatatgatattcctggagatatcctatctattattgatgcaaaaaacg a cgattggaaaaaatattttattagtttttataaagctaattttattaacggtaatacatttattagtgatagaacgttt aacgag gacttattcagagttgttgttcaaatagatcccgaatatttcgataatgaacgaattatgtctttattctctacgagtg ctgcg gacattaaacgatttgatgagttagatattaataacagttatatatctaatataatttatgaggtgaacgatatcacat tag atacaatggatgatatgaagaagtgtcaaatctttaacgaggatacgtcgtattatgttaaggaatacaatacatacct g thttgcacgagtcggatcccatggtcatagagaacggaatactaaagaaactgtcatctataaaatccaagagtaga cggctgaacttgtttagcaaaaacattttaaaatattatttagacggacaattggctcgtctaggtcttgtgttagatg attat aaaggagacttgttagttaaaatgataaaccatcttaagtctgtggaggatgtatccgcattcgttcgattttctacag ata aaaaccctagtattcttccatcgctaatcaaaactattttagctagttataatatttccatcatcgtcttatttcaaag gtttttg agagataatctatatcatgtagaagaattcttggataaaagcatccatctaaccaagacggataagaaatatatacttc aattgataagacacggtagatcatagaacagaccaaatatattattaataatttgtatatacatagatataattatcac ac atttttgataaatgggaactgctgcaacaattcagactcccaccaaattaatgaataaagaaaatgcagaaatgatttt ggaaaaaattgttgatcatatagttatgtatattagtgacgaatcaagtgattcagaaaataatcctgaatatattgat tttc gtaacagatacgaagactatagatctctcattataaaaagtgatcacgagtttgtaaagctatgtaaaaatcatgcaga gaaaaglictccagaaacgcaacaaatgattatcaaacacatatacgaacaatatcttattccagtatctgaagtacta ttaaaacctataatgtccatgggtgacataattacatataacggatgtaaagacaatgaatggatgctagaacaactct ctaccctaaactttaacaatctccgcacatggaactcatgtagcataggcaatgtaacgcgtctgttttatacattttt tagtt atctgatgaaagataaactaaatatataagtataatcccattctaatactttaacctgatgtattacctgcatcttatt agaa tattaacctaactaaaagacataacatagttgataaaaagcggtaggatataaatattatggctgccaccgttccgcgt t ttgacgacgtgtacaaaaatgcacaaagaagaattctagatcaagaaacatlitttagtagaggtctaagtagaccgtt aatgaaaaacacatatctatttgataattacgcgtatggatggataccagaaactgcaatttggagtagtagatacgca aacttagatgcaagtgactattatcccatttcgttgggattacttaaaaagttcgagtttctcatgtctctatataaag gtcct attcccgtatatgaagaaaaagtaaatactgaattcattgctaatggatcgttctctggtagatacgtatcatatcttc gaa agttttctgcccttccaacaaacgagtttattagttlittgttactgacttccattccaatctataatatcttgttctg gtttaaaaa tactcagtttgatattactaaacacacattattcagatacgtctatacagataatgccaaacacctggcgttggctagg ta tatgcatcaaacaggagactataagcctttgtttagtcgtctcaaagagaattatatatttaccggtcccgttccaata agt atcaaagatatagatcaccctaatcttagtagagcaagaagtccatccgattatgagacattagctaatattagtacta t attgtactttaccaagtatgatccggtattaatgtttttattgttttacgtacctgggtattcaattactacaaaaatt actccag ccgtagaatatctaatggataaactgaatctaacaaagagcgacgtacaactgttgtaaattattttatgcttcgtaaa at gtaggttttgaaccaaacattctttcaaagaatgagatgcataaaactttattatccaatagattgactatttcggacg tca atcgtttaaagtaaacttcgtaaaatattctttgatcactgccgagtttaaaacttctatcgataattgtttcatatgt tttaatat ttacaagttttttggtccatggtacattagccggacaaatatatgcaaaataatatcgttctccaagttctatagtttc tggatt atttttattatattcagtaaccaaatacatattagggttatctgcggatttataatttgagtgatgcattcgactcaac ataaat aattctagaggagacgatctactatcaaattcggatcgtaaatctgtttctaaagaacggagaatatctatacatacct g attagaattcatccgtccttcagacaacatctcagacagtctggtcttgtatgtcttaatcatattcttatgaaacttg gaaa catctcttctagtttcactagtacctttattaattctctcaggtacagattttgaattcgacgatgctgagtatttcat cgttgtat atttcttcttcgattgcataatcagattcttatataccgcctcaaactctattttaaaattattaaacaatactctatt attaatca gtcgttctaactclitcgctatttctatagacttatcgacatcttgactgtctatctctgtaaacacggagtcggtatc tccata cacgctacgaaaacgaaatctgtaatctataggcaacgatgttttcacaatcggattaatatctctatcgtccatataa a atggattacttaatggattggcaaaccgtaacataccgttagataactctgctccatttagtaccgattctagatacaa ga tcattctacgtcctatggatgtgcaactcttagccgaagcgtatgagtatagagcactatttctaaatcccatcagacc at atactgagttggctactatcttgtacgtatattgcatggaatcatagatggccttttcagttgaactggtagcctgttt tagcat ctttttatatctggctctctctgccaaaaatglicttaatagtctaggaatggttccttctatcgatctatcgaaaatt gctatttc agagatgaggttcggtagtctaggttcacaatgaaccgtaatatatctaggaggtggatatttctgaagcaagagctga ttatttatttcttcttccaatctattggtactaacaacgacaccgactaatglitccggagatagatttccaaagatac acac attaggatacagactgttataatcaaagattaatacattattactaaacattttttgttttggagcaaataccttaccg ccttc ataaggaaacttttgttttgtttctgatctaactaagatagttttagtttccaacaatagctttaacagtggacccttg atgact gtactcgctctatattcgaataccatggattgaggaagcacatatgttgacgcacccgcgtctgtttttgtttctactc cata atactcccacaaatactgacacaaacaagcatcatgaatacagtatctagccatatctaaagctatgtttagattataa t ccttatacatctgagctaaatcaacgtcatcctttccgaaagataatttatatgtatcattaggtaaagtaggacatga tag tacgactttaaatccattttcccaaatatctttacgaattactttacatataatatcctcatcaacagtcacataatta cctgtg gttaaaacctttgcaaatgcagcggctttgcctttcgcgtccgtagtatcgtcaccgatgaacgtcatttctctaactc ctct atttaatactttacccatgcaactgaacgcgttcttggatatagaatccaatttgtacgaatccaatttttcagatlit tgaatg aatgaatatagatcgaaaaatatagttccattattgttattaacgtgaaacgtagtattggccatgccgcctactccct tat gactagactgatttctctcataaatacagagatgtacagcttcctttttgtccggagatctaaagataatcttctctcc tgtta ataactctagacgattagtaatatatctcagatcaaagttatgtccgttaaaggtaacgacgtagtcgaacgttagttc ca acaattgtttagctattcgtaacaaaactatttcagaacatagaactagttctcgttcgtaatccatttccattagtga ctgta tcctcaaacatcctctatcgacggcttcttgtatttcctgttccgttaacatctcttcattaatgagcgtaaacaataa tcgttt accacttaaatcgatataacagtaacttgtatgcgagattgggttaataaatacagaaggaaacttcttatcgaagtga cactctatatctagaaataagtacgatcttgggatatcgaatctaggtatttttttagcgaaacagttacgtggatcgt cac aatgataacatccattgttaatctttgtcaaatattgctcgtccaacgagtaacatccgtctggagatatcccgttaga aat ataaaaccaactaatattgagaaattcatccatggtggcattttgtatgctgcgtttctttggctcttctatcaaccac atatc tgcgacggagcattttctatctttaatatctagattataacttattgtctcgtcaatgtctatagttctcatctttccc aacggcct cgcattaaatggaggaggagacaatgactgatatatttcgtccgtaactacgtaataaaagtaatgaggaaatcgtat aaatacggtctcgccatttcgacatctggatttcagatataaaaatctglittcaccgtgactttcaaaccaattaatg cac cgaacatccatttatagaatttagaaatatattttcatttaaatgaatcccaaacattggggaagagccgtatggacca tt atttttatagtactttcgcaagcgggtttagacggcaacatagaagcgtgtaaacgaaaactatatactatagtcagca c tcttccatgtcctgcatgtagacggcacgcgactatcgctatagaggacaataatgtcatgtctagcgatgatctgaat t atatttattattttttcatcagattatttaacaatttggcatctgatcccaaatacgcgatcgatgtgacaaaggttaa cccttt ataaacttaacccattataaaacttatgattagtcacgactgaaataaccgcgtgattattttttggtataattctaca cggc atggtttctgtaactatgaattcaacccccgttacattagtgaaatctttaacaaacagcaagggttcgtcaaagacat a aaactcattgtttacaatcgaaatagaccccctatcacacttaaaataaaaaatatccttatcctttaccaccaaataa a attctgattggtcaatgtgaatgtattcacttaacagttccacaaatttatttattaactccgaggcacatacatcgtc ggtat tttttatggcaaactttactcttccagcatccgtttctaaaaaaatattaacgagttccatttatatcatccaatatta ttgaaat gacgttgatggacagatgatacaaataagaaggtacggtacctligtccaccatctcctccaattcatgctctattttg tca ttaactttaatgtatgaaaacagtacgccacatgcttccatgacagtgtgtaacactttggatacaaaatgtttgacat tag tataattgtccaagactgtcaatctataatagatagtagctataatatattctatgatggtattgaagaagatgacaat cttg gcatattgatcatttaacacagacatggtatcaacagatagcttgaatgaaagagaatcagtaattggaataagcgtct tctcgatagagtgtccgtataccaacatgtctgatattttgatgtattccattaaattatttagttttttctttttatt ctcgttaaaca gcatttctgtcaacggaccccaacatcgttgaccgattaagttttgattgatttttccgtgtaaggcgtatctagtcag atcg tatagcctatccaataatccatcatctgtgcgtagatcacatcgtacactttttaattctctatagaagagcgacagac ag caatttctttattctctacagatgtaagatacttgaagacattcctatgatgatgcagaattttggataacacggtatt gatg gtatctgttaccataattcctttgatggctgatagtgtcagagcacaagatttccaatclitgttttgatatctatatc agacag catggtgcgtctgacaacacaaggattaagacggaaagatgaaatgattctctcaacatcttcaatggataccttgcta ttttttctggcattatctatatgtgcgagaatatcctctagagaatcagtatcctttttgatgatagtggatctcaatg acatgg gacgtctaaaccttcttattctatcaccagattgcatggtgatttgtcttctttcttttatcataatgtaatctctaaa ttcatcggc aaattgtctatatctaaaatcataatatgagatgtttacctctacaaatatctgttcgtccaatgttagagtatctaca tcagtt ttgtattccaaattaaacatggcaacggatttaattttatattcctctattaagtcctcgtcgataataacagaatgta gata atcatttaatccatcgtacatggttggaagatgcttgttgacaaaatctttaattgtcttgatgaaggtgggactatat ctaa catcttgattaataaaatttataacattgtccataggatactttgtaactagttttatacacatctcttcatcggtaag tttagac agaatatcgtgaacaggtggtatattatattcatcagatatacgaagaacaatgtccaaatctatattgtttaatatat tata tagatgtagcgtagctcctacaggaatatctttaactaagtcaatgatttcatcaaccgttagatctattttaaagtta atcat ataggcattgatttttaaaaggtatgtagccttgactacattctcattaattaaccattccaagtcactgtgtgtaaga agat tatattctatcataagcttgactacatttggtcccgataccattaaagaattcttatgatataaggaaacagattttag gtac tcatctactctacaagaattttggagagccttaacgatatcagtgacgtttattatttcaggaggaaagaatctaacat tg agaatatcggaattaatagcttccagatacagtgattttggcaatagtccgtgtaatccataatccagtaacacgagct g gtgcttgctagacaccttttcaatgtttaatttttttgaaataagctttgataaagccttcctcgcaaattccggatac atgaa catgtcggcgacatgattaagtattgttttttcattattttctcaacaagttctcaataccccaatagatgatagaata tcacc caatgcgtccatgttgtctatttccaacaggtcgctatatccaccaatagaagtttttccaaaaaagattctaggaaca gt tctaccaccagtaatttgttcaaaatagtcacgcaattcattttcgggtttaaattctttaatatcgacaatttcatac gctcct cttttgaaactaaacttatttagaatatccagtgcatttctacaaaaaggacatgtatacttgacaaaaattgtcactt tgtt attggccaacctttgttgtacaaattcctcggccattttaatatttaagtgatataaaactatctcgacttatttaact ctttagt cgagatatatggacgcagatagctatatgatagccaactacagaaggcaaacgctataaaaaacataattacgacg agcatatttataaatatttttattcagcattacttgatatagtaatattaggcacagtcaaacattcaaccactctcga tacat taactctctcattttctttaacaaattctacaatatcttcgtaaaaagattcttgaaactttttagaatatctatcgac tctagat gaaatagcgttcgtcaacatactatgttttgtatacataaaggcgcccattttaacagtttctagtgacaaaatgctag cg atcctaggatcctttagaatcacatagattgacgattcgtctctcttagtaactctagtaaaataatcatacaatctag tac gcgaaataatattatccttgacttgaggagatctaaacaatctagttttgagaacatcgataagttcatcgggaatgac a tacatactatctttaatagaactcttttcatccagttgaatggattcgtccttaaccaactgattaatgagatcttcta ttttatc attttccagatgatatgtatgtccattaaagttaaattgtgtagcgcttctttttagtctagcagccaatactttaaca tcacta atatcgatatacaaaggagatgatttatctatggtattaagaattcgtttttcgacatctgtcaaaaccaattcctttt tgcctg tatcatccagttttccatcctttgtaaagaaattattttctactagactattaataagactgataaggattcctccata attgca caatccaaactttttaacaaaactagactttacaagatctacaggaatgcgtaattcaggtttcttagcttgtgatttt ttctttt gtggacattttcttgtgaccaactcatctaccatttcattgattttagcagtgaaataagctttcaatgcacgggcact gata ctattgaaaacgagttgatcttcaaattccgccatttaagttcaccaaacaacttttaaatacaaatatatcaatagta gta gaataagaactataaaaaaaataataattaaccaataccaaccccaacaaccggtattattagttgatgtgactgtttt c tcatcacttagaacagatttaacaatttctataaagtctgtcaaatcatcttccggagaccccataaatacaccaaata ta gcggcgtacaacttatccatttatacattgaatattggcttttctttatcgctatcttcatcatattcatcatcaatat caacaag tcccagattacgagccagatcttcttctacattttcagtcattgatacacgttcactatctccagagagtccgataacg tta gccaccacttctctatcaatgattagtttcttgagtgcgaatgtaatttttgtttccgttccggatctatagaagacga taggt gtgataattgccttggccaattgtctttctcttttactgagtgattctagttcaccttctatagatctgagaatggatg attctcc agtcgaaacatattctaccatggatccgtttaatttgttgatgaagatggattcatccttaaatgttttctctgtaata gtttcca ccgaaagactatgcaaagaatttggaatgcgttccttgtgcttaatgtttccatagacggclictagaagttgatacaa ca taggactagccgcggtaacttttatttttagaaagtatccatcgcttctatcttgtttagatttatttttataaagttt agtctctcct tccaacataataaaagtggaagtcatttgactagataaactatcagtaagttttatagagatagacgaacaattagcgt attgagaagcatttagtgtaacgtattcgatacattttgcattagatttactaatcgattttgcatactctataacacc cgcac aagtctgtagagaatcgctagatgcagtaggtcttggtgaagtttcaactctcttcttgattaccttactcatgattaa acct aaataattgtactttgtaatataatgatatatattttcactttatctcatttgagaataaaaatgtttttgtttaacca ctgcatgat gtacagatttcggaatcgcaaaccaccagtgglittattttatccttgtccaatgtgaattgaatgggagcggatgcgg gtt tcgtacgtagatagtacattcccgtttttagaccgagactccatccgtaaaaatgcatactcgttagtttggaataact cg gatctgctatatggatattcatagattgactttgatcgatgaaggctcccctgtctgcagccatttttatgatcgtctt ligtgg aatttcccaaatagttttataaactcgcttaatatcttctggaagglitgtattctgaatggatccaccatctgccata atcct attcttgatctcatcattccataattttctctcggttaaaactctaaggagatgcggattaactacttgaaattctcca gaca atactctccgagtgtaaatattactggtatacggttccaccgactcattatttcccaaaatttgagcagttgatgcagt cgg cataggtgccaccaataaactatttctaagaccgtatgttctgattttatcttttagaggttcccaattccaaagatcc gacg gtacaacattccaaagatcatattgtagaataccgttactggcgtacgatcctacatatgtatcgtatggtccttcctt ctca gctagttcacaactcgcctctaatgcaccgtaataaatggtttcgaagatcttcttatttagatcttgtgcttccaggc tatca aatggataatttaagagaataaacgcgtccgctaatccttgaacaccaataccgataggtctatgtctcttattagaga tt tcagcttctggaataggataataattaatatctataattttattgagatttctgacaattactttgaccacatccttca gtttga gaaaatcaaatcgcccatctattacaaacatgttcaaggcaacagatgccagattacaaacggctacctcattagcat ccgcatattgtattatctcagtgcaaagattactacacttgatagttcctaaattttgttgattactctttttgttaca cgcatcct tataaagaatgaatggagtaccagtttcaatctgagattctataatcgctttccagacgactcgagcctttattataga tttg tatctcctttctctttcgtatagtgtatacaatcgttcgaactcgtctccccaaacattgtccaatccaggacattcat ccgga cacatcaacgaccactctccgtcatccttcactcgtttcataaagagatcaggaatccaaagagctataaatagatctc tggttctatgttcctcgtttcctgtattctttttaagatcgaggaacgccataatatcagaatgccacggttccaagta tatgg ccataactccaggccgtttglitcctccctgatctatgtatctagcggtgttattataaactctcaacattggaataat accgt ttgatataccattggtaccggagatatagcttccactggcacgaatattactaattgatagacctattccccctgccat ttta gagattaatgcgcatcgttttaacgtgtcatagataccctctatgctatcatcgatcatgttaagtagaaaacagctag ac atttggtgacgactagttcccgcattaaataaggtaggagaagcgtgcgtaaaccatttttcagaaagtagattgtacg t ctcaatagctgagtctatatcccattgatgaattcctactgcgacacgcattaacatgtgctgaggtctttcaacgatc ttgt tgtttattttcaacaagtaggatttttccaaagttttaaaaccaaaatagttgtatgaaaagtctcgttcgtaaataat aacc gagttgagtttatccttatatttgttaactatatccatggtgatacttgaaataatcggagaatgtttcccatttttag gattaac atagttgaataaatcctccatcacttcactaaatagtttttttgthccttgtgtagatttgatacggctattctggcgg ctagaa tggcataatccggatgttgtgtagtacaagtggctgctatttcggctgccagagtgtccaattctaccgttgttactcc atta tatattccttgaataaccttcatagctattttaataggatctatatgatccgtgtttaagccataacataattttctaa tacgag acgtgattttatcaaacatgacattttccttgtatccatttcgtttaatgacaaacatttttgttggtgtaataaaaaa aattattt

-73-aacttttcattaatagg gatttgacgtatgtagcgtacaaaattatcgttcctggtatatagataaagagtcctatatatttg a aaatcgttacggctcgattaaactttaatgattgcatagtgaatatatcattaggatttaactccttgactatcatggc ggcg ccagaaattaccatcaaaagcattaatacagttatgccgatcgcagttagaacggttatagcatccaccatttatatct a aaaattagatcaaagaatatgtgacaaagtcctagttgtatactgagaattgacgaaacaatgtttcttacatattttt ttttt attagtaaccgacttaatagtaggaactggaaaactagacttgattattctataagtatagatacccttccaaataata tt ctctttgataaaagttccagaaaatgtagaattttttaaaaagttatcttttgctattaccaagattgtgtttagacgc ttattatt aatatgagtgatgaaatccacaccgcctctagatatcgclittatttccacattagatggtaaatccaatagtgaaact at ctttttaggaatgtatggactcgcgtttagaggagtgaacgtcttaggcgtcggaaaggggccggcctlittttctaga ca ctaaataaatagtaagattaaattaattataaaattatgtatataatattaattataaaattatgtatatgatttacta acttta gttagataaattaataatacataaattttagtatattaatattataaattaataatacataaattttagtatattaata ttatatttt aaatatttatttagtgtctagaaaaaaaggcctagcaggcc [0073] Sequence of sMVA fragment 2 (F2, 63035 bp in length) (deposited with NCB! under Accession No.
MW023924, www.ncbi.nlm.nih.gov/nuccore/MW023924.1/) (SEQ ID NO: 13):
ggcctagcaggcctttttttctagacactaaataaatagtaagattaaattaattataaaattatgtatataatattaa ttata aaattatgtatatgatttactaactttagttagataaattaataatacataaattttagtatattaatattataaatta ataatac ataaattttagtatattaatattatattttaaatatttatttagtgtctagaaaaaaaggccggccataaaaatgtttt tgtttaa ccactgcatgatgtacagatttcggaatcgcaaaccaccagtggttttattttatccttgtccaatgtgaattgaatgg gag cggatgcgggtttcgtacgtagatagtacattcccgtttttagaccgagactccatccgtaaaaatgcatactcgttag ttt g gaataactcggatctg ctatatg gatattcatag attgactttg atcgatgaaggctcccctg tctg cag ccatttttatg a tcgtcttttgtggaatttcccaaatagttttataaactcgcttaatatcttctggaaggtttgtattctgaatggatcc accatct gccataatcctattcttgatctcatcattccataattttctctcggttaaaactctaaggagatgcggattaactactt gaaat tctccag acaatactctccg a gtgtaaatattactg g tata cg gttccaccg a ctcattatttcccaaaatttg ag cagttg atg cagtcg gcataggtg cca ccaataaactatttctaagaccg tatgttctg attttatcttttag aggttcccaattcca a ag atccg acggtacaacattccaaagatcatattgtagaataccgttactg gcgtacgatcctacatatgtatcgtatgg tccttccttctcagctagttcacaactcgcctctaatgcaccgtaataaatggtttcgaagatcttcttatttagatct tgtgctt ccaggctatcaaatggataatttaag agaataaacg cgtccg ctaatccttgaacaccaataccgataggtctatgtct cttatta g ag atttcag cttctg g aatag g ataataatta atatctataattttattg ag atttctg a caatta ctttg accacat ccttcagtttgagaaaatcaaatcgcccatctattacaaacatgttcaaggcaacagatgccagattacaaacggcta cctcattagcatccgcatattgtattatctcagtgcaaagattactacacttgatagttcctaaattttgttgattact ctttttgtt acacgcatccttataaagaatgaatggagtaccagtttcaatctgagattctataatcgctttccagacgactcgagcc tt tattatag atttgtatctcctttctctttcgtatag tg tatacaatcgttcg aactcgtctccccaa acattgtccaatccag g a cattcatccggacacatcaacgaccactctccgtcatccttcactcgtttcataaagagatcaggaatccaaagagcta

-74-taaatagatctctggttctatgttcctcgtttcctgtattctttttaagatcgaggaacgccataatatcagaatgcca cggtt ccaagtatatggccataactccaggccgtttgtttcctccctgatctatgtatctagcggtgttattataaactctcaa cattg gaataataccgtttgatataccattggtaccggagatatagcttccactggcacgaatattactaattgatagacctat tc cccctgccattttagagattaatgcgcatcgttttaacgtgtcatagataccctctatgctatcatcgatcatgttaag taga aaacagctagacatttggtgacgactagttcccgcattaaataaggtaggagaagcgtgcgtaaaccatttttcagaa agtagattgtacgtctcaatagctgagtctatatcccattgatgaattcctactgcgacacgcattaacatgtgctgag gt ctttcaacgatcttgttgtttattttcaacaagtaggatttttccaaagttttaaaaccaaaatagttgtatgaaaagt ctcgtt cgtaaataataaccgagttgagtttatccttatatttgttaactatatccatggtgatacttgaaataatcggagaatg thcc catttttaggattaacatagttgaataaatcctccatcacttcactaaatagtttttttgtttccttgtgtagatttga tacggctat tctggcggctagaatggcataatccggatgttgtgtagtacaagtggctgctatttcggctgccagagtgtccaattct ac cgttgttactccattatatattccttgaataaccttcatagctattttaataggatctatatgatccgtgtttaagcca taacata attttctaatacgagacgtgattttatcaaacatgacattttccttgtatccatttcgtttaatgacaaacatttttgt tggtgtaa taaaaaaaattatttaacttttcattaatagggatttgacgtatgtagcgtacaaaattatcgttcctggtatatagat aaag agtcctatatatttgaaaatcgttacggctcgattaaactttaatgattgcatagtgaatatatcattaggatttaact ccttg actatcatggcggcgccagaaattaccatcaaaagcattaatacagttatgccgatcgcagttagaacggttatagca tccaccatttatatctaaaaattagatcaaagaatatgtgacaaagtcctagttgtatactgagaattgacgaaacaat g tttcttacatattttttttttattagtaaccgacttaatagtaggaactggaaaactagacttgattattctataagta tagatac ccttccaaataatattctctttgataaaagttccagaaaatgtagaattttttaaaaagttatcttttgctattaccaa gattgt gtttagacgcttattattaatatgagtgatgaaatccacaccgcctctagatatcgcttttatttccacattagatggt aaatc caatagtgaaactatctttttaggaatgtatggactcgcgtttagaggagtgaacgtcttaggcgtcggaaaggatgat t catcaaacgaataaacaatttcacaaatggatgttaatgtattagtaggaaattttttgacgctagtggaattgaagat tct aatggatgatgttctacctatttcatccgataacatgttaatttccgacaccaacggttttaatatttcgatgatatac ggtag tctctctttcggacttatatagcttattccacaatacgagtcattatatactccaaaaaacaaaataactagtataaaa tct gtatcgaatgggaaaaacgaaattatcgacataggtatagaatctggaacattgaacgtattaatacttaattcttttt ctg tggtaagtaccgataggttattgacattgtatggttttaaatattctataacttgagacttgatagatattagtgatga attga aaattattlitatcaccacgtgtgtttcaggatcatcgtcgacgcccgtcaaccaaccgaatggagtaaaataaatatc a ttaatatatgctctagatattagtatttttatcaatcctttgattatcatcttctcgtaggcgaatgattccatgatca agagtga tttaagaacatcctccggagtattaatgggcttagtaaacagtccatcgttgcaataataaaagttatccaagttaaag g atattatgcattcgtttaaagatatcacctcatctgacggagacaattttttggtaggttttagagactttgaagctac ttgttt aacaaagttattcatcgtcgtttactattctatttaattttgtagttaatttatcacatatcacattaattgacttttt ggtccatttttc catacgtttatattcttttaatcctgcgttatccgtttccgttatatccagggatagatcttgcaagttaaatagaatg ctcttaa ataatgtcattttcttatccgctaaaaatttaaagaatgtataaacctttttcagagatttgaaactcttaggtggtgt cctagt acacaatatcataaacaaactaataaacattccacattcagattccaacagctgattaacttctacattaatacagcct a ttttcgctccaaatgtacattcgaaaaatctgaataaaacatcgatgtcacaatttgtattatccaatacagaatgttt gtga

-75-ttcgtgttaaaaccatcggagaaggaataaaaataaaaattattatagtggtggaattcagttggaatattgcctccgg a gtcataaaaggatactaaacattglittttatcataaattacacatttccaatgagacaaataacaaaatccaaacatt ac aaatctagaggtagaactlitaattligtclitaagtatatacgataagatatglitattcataaacgcgtcaaattli tcatga atcgctaaggagtttaagaatctcatgtcaaattgtcctatataatccacttcggatccataagcaaactgagagacta a glicttaatacttcgattgctcatccaggctcctctctcaggctctattlicatcttgacgacctliggattlicacca gtatgtat tcctttacgtgataaatcatcgattlicaaatccatttgtgagaagtctatcgccttagatactlittcccgtagtcga gglita aagaaatacgctaacggtatactagtaggtaactcaaagacatcatatatagaatggtaacgcgtclitaactcgtcgg ttaactclitclittgatcgagttcgtcgctactattgggtctgctcaggtgccccgactctactagttccaacatcat accgat aggaatacaagacactttgccggcggligtagatttatcatatttctccactacatatccgttacaatttgttaaaaat ttag atacatctatattgctacataatccagctagtgaatatatatgacataataaattggtaaatcctagttctggtatttt actaa ttactaaatctgtatatclitccatttatcatggaaaagaatttaccagatatclicttlittccaaactgcgttaatg tattctctt acaaatattcacaagatgaattcagtaatatgagtaaaacggaacgtgatagtlictcattggcggtglitccagttat aa aacatagatggcataacgcacacgttgtaaaacataaaggaatatacaaagttagtacagaagcacgtggaaaaa aagtatctcctccatcactaggaaaacccgcacacataaacctaaccgcgaagcaatatatatacagtgaacacac aataagctttgaatgttataglittctaaaatgtataacaaatacagaaatcaattcgttcgatgagtatatattaaga gga ctattagaagctggtaatagtttacagatattliccaattccgtaggtaaacgaacagatactataggtgtactaggga at aagtatccatttagcaaaattccattggcctcattaactcctaaagcacaacgagagatattlicagcgtggatttctc at agacctgtaglittaactggaggaactggagtgggtaagacgtcacaggtacccaagttattgctligglitaattatt tatt tggtggattctctactctagataaaatcactgactlicacgaaagaccagtcattctatctcttcctaggatagcttta gtta gattgcatagcaataccattttaaaatcattgggatttaaggtactagatggatctcctatttctttacggtacggatc tatac cggaagaattaataaacaaacaaccaaaaaaatatggaattgtattttctacccataagttatctctaacaaaactatt t agttatggcactcttattatagacgaagttcatgagcatgatcaaataggagatattattatagcagtagcgagaaagc atcatacgaaaatagattctatglitttaatgactgccacgttagaggatgacagggaacggctaaaagtattlitacc ta atcccgcatttatacatattcctggagatacactglitaaaattagcgaggtatttattcataataagataaatccatc licc agaatggcatacatagaagaagaaaagagaaatttagttactgctatacagatgtatactcctcctgatggatcatcc ggtatagtctligtggcatccgttgcacagtgtcacgaatataaatcatatttagaaaaaagattaccgtatgatatgt ata ttattcatggtaaggtcttagatatagacgaaatattagaaaaagtgtattcatcacctaatgtatcgataattatttc tactc cttatttggaatccagcgttactatacgcaatgttacacacatttatgatatgggtagagtlittgtccccgctcclit tggag gatcgcaagaatttatttctaaatctatgagagatcaacgaaaaggaagagtaggaagagttaatcctgggacatac gtatatttctatgatctgtcttatatgaagtctatacagcgaatagattcagaatttctacataattatatattgtacg ctaata agtttaatctaacactccccgaagatttglitataatccctacaaatttggatattctatggcgtacaaaggaatatat aga ctcgttcgatattagtacagaaacatggaataaattattatccaattattatatgaagatgatagagtatgctaaactt tatg tactaagtcctattctcgctgaggagttggataattttgagaggacgggagaattaactagtattgtacaagaagccat tt tatctctaaatttacgaattaagattttaaattttaaacataaagatgatgatacgtatatacacttligtaaaatatt attcgg

-76-tgtctataacggaacaaacgctactatatattatcatagacctctaacgggatatatgaatatgatttcagatactata ttt gttcctgtagataataactaaaaatcaaactctaatgaccacatctttttttagagatgaaaaattttccacatctcct tttgt agacacgactaaacattttgcagaaaaaagtttattagtgtttagataatcgtatacttcatcagtgtagatagtaaat gtg aacagataaaaggtattcttgctcaatagattggtaaattccatagaatatattaatcctttcttcttgagatcccaca tcatt tcaaccagagacgttttatccaatgatttacctcgtactataccacatacaaaactagattttgcagtgacgtcgtatc tgg tattcctaccaaacaaaattttacttttagttcttttagaaaattctaaggtagaatctctatttgccaatatgtcatc tatggaa ttaccactagcaaaaaatgatagaaatatatattgatacatcgcagctggttttgatctactatactttaaaaacgaat ca gattccataattgcctgtatatcatcagctgaaaaactatgttttacacgtattccttcggcatttctttttaatgata tatcttgtt tagacaatgataaagttatcatgtccatgagagacgcgtctccgtatcgtataaatatttcattagatgttagacgctt catt aggggtatacttctataaggtttcttaatcagtccatcattggttgcgtcaagaactactatcggatgttgttgggtat ctcta gtgttacacatggccttactaaagtttgggtaaataactatgatatctctattaattatagatgcatatatttcatttg tcaagg atattagtatcgacttgctatcgtcattaatacgtgtaatgtaatcatataaatcatgcgatagccaaggaaaatttaa ata gatgttcatcatataatcgtcgctataattcatattaatacgttgacattgactaatttgtaatatagcctcgccacga agaa agctctcgtattcagtttcatcgataaaggataccgttaaatataactggttgccgatagtctcatagtctattaagtg gtaa gtttcgtacaaatacagaatccctaaaatattatctaatgttggattaatctttaccataactgtataaaatggagacg ga gtcataactattttaccgtttgtacttactggaatagacgaaggaataatctccggacatgctggtaaagacccaaatg t ctgtttgaagaaatccaatgttccaggtcctaatctcttaacaaaaattacgatattcgatcccgatatcctttgcatt ctattt accagcatatcacgaactatattaagattatctatcatgtctattctcccaccgttatataaatcgcctccgctaagaa ac gttagtatatccatacaatggaatacttcatttctaaaatagtattcgttttctaattctttaatgtgaaatcgtatac tagaaa gggaaaaattatctttgagttttccgttagaaaagaaccacgaaactaatgttctgattgcgtccgattccgttgctga att aatggatttacaccaaaaactcatataacttctagatgtagaagcattcgctaaaaaattagtagaatcaaaggatata agtagatgttccaacaagtgagcaattcccaagatttcatctatatcattctcgaatccgaaattagaaattcccaagt a gatatcctttttcatccgatcgttgatgaaaatacgaactttattcggtaagacaatcatttactaaggagtaaaatag ga agtaatgttcgtatgtcgttatcatcgtataaattaaaggtgtgttttttaccattaagtgacattataattttaccaa tattgga attataatataggtgtatttgcgcactcgcgacggttgatgcatcggtaaatatagctgtatctaatgttctagtcggt atttc atcatttcgctgtctaataatagcgttttctctatctgtttccattacagctgcctgaagtttattggtcggataatat gtaaaat aataagaaatacatacgaataacaaaaataaaataagatataataaagatgccatttagagatctaattttgtttaact t gtccaaattcctacttacagaagatgaggaatcgttggagatagtgtcttccttatgtagaggatttgaaatatcttat gat gacttgataacttactttccagataggaaataccataaatatatttctaaagtatttgaacatgtagatttatcggagg aatt aagtatggaattccatgatacaactctgagagatttagtctatcttagattgtacaagtattccaagtgtatacggccg tgt tataaattaggagataatctaaaaggcatagligttataaaggacaggaatatttatattagagaagcaaatgatgact t gatagaatatctcctcaaggaatacactcctcagatttatacatattctaatgagcgcgtccccataactggttcaaaa tt aattctttgtggattttctcaagttacatttatggcgtatacaacgtcgcatataacaacaaataaaaaggtagatgtt ctc gtttccaaaaaatgtatagatgaactagtcgatccaataaattatcaaatacttcaaaatttatttgataaaggaagcg g

-77-aacaataaacaaaatactcaggaagatattttattcggtaaccggtggccaaactccataatttgctttttctatttcg gatt ttagaatttccaaattcaccagcgatttatcggttttggtgaaatccaaggatttattaatgtccacaaatgccatttg littgt ctgtggattgtatttgaaaatggaaacgatgtagttagatagatgcgctgcaaagtttcctattagggttccgcgcttt acg tcacccagcatacttgaatcaccatcctttaaaaaaaatgataagatatcaacatggagtatatcatactcggatttta at tcttctactgcatcactgacattttcacaaatactacaatacggtttaccgaaaataatcagtacgttcttcatttatg ggtat caaaaacttaaaatcgttactgctggaaaataaatcactgacgatattagatgataatttatacaaagtatacaatgga atatttgtggatacaatgagtatttatatagccgtcgccaattgtgtcagaaacttagaagagttaactacggtattca taa aatacgtaaacggatgggtaaaaaagggagggcatgtaaccctttttatcgatagaggaagtataaaaattaaaca agacgttagagacaagagacgtaaatattctaaattaaccaaggacagaaaaatgctagaattagaaaagtgtaca tccgaaatacaaaatgttaccggatttatggaagaagaaataaaggcagaaatgcaattaaaaatcgataaactca catttcaaatatatttatctgattctgataacataaaaatatcattgaatgagatactaacacatttcaacaataatga gaa tgttacattattttattgtgatgaacgagacgcagaattcgttatgtgtctcgaggctaaaacacatttctctaccaca gga gaatggccgttgataataagtaccgatcaggatactatgctatttgcatctactgataatcatcctaagatgataaaaa a cttaactcaactgtttaaatttgttccctcggcagaggataactatttagcaaaattaacggcgttagtgaatggatgt gat ttctttcctggactctatggggcatctataacacccaccaacttaaacaaaatacaattgtttagtgattttacaatcg ata atatagtcactagtttggcaattaaaaattattatagaaagactaactctaccgtagacgtgcgtaatattgttacgtt tata aacgattacgctaatttagacgatgtctactcgtatgttcctccttgtcaatgcactgttcaagaatttatattttccg cattag atgaaaaatggaacaattttaaatcatcttatttagagaccgttccgttaccctgccaattaatgtatgcattagaacc ac gcaaggagattgatgtttcagaagttaaaactttatcatcttatatagatttcgaaaatactaaatcagatatcgatgt tata aaatctatatcttcgatcttcggatattctaacgaaaactgtaacactatagtglicggcatctataaggataatttac tact gagtataaatagttcattttactttaacgatagtctgttaataaccaatactaaaagtgataatataataaatataggt tact agattaaaaatggtgttccaactcgtgtgctctacgtgcggcaaagatatttctcacgaacgatataaattgattatac ga aaaaaatcattaaaggatgtactcgtcagtgtaaagaacgaatgligtaggttaaaattatctacacaaatagaacctc aacgtaacttaacagtgcaacctctattggatataaactaatatggatccggttaattttatcaagacatatgcgccta ga ggttctattatttttattaattataccatgtcattaacaagtcatttgaatccatcgatagaaaaacatgtgggtattt attatgg tacgttattatcggaacacttggtagttgaatctacctatagaaaaggagttcgaatagtcccattggatagttttttt gaag gatatcttagtgcaaaagtatacatgttagagaatattcaagttatgaaaatagcagctgatacgtcattaactttatt ggg tattccgtatggatttggtcataatagaatgtattgttttaaattggtagctgaatgttataaaaatgccggtattgat acatc gtctaaacgaatattaggtaaagatatttttctgagccaaaacttcacagatgataatagatggataaagatatatgat tc taataatttaacattttggcaaattgattaccttaaagggtgagttaatatgcataactactcctccgttgttttttcc ctcgttct ttttcttaacgttgtttgccatcactctcataatgtaaagatattctaaaatggtaaacttttgcatatcggacgcaga aattg gtataaatgttgtaattgtattatttcccgtcaatggactagtcacagctccatcagttttatatcctttagagtattt ctcactc gtgtctaacattctagagcattccatgatctgtttatcgttgatattggccggaaagatagattttttattttttatta tattactatt ggcaattgtagatataacttctggtaaatatttlictaccttttcaatctcttctattttcaagccggctatatattct gctatattgt

-78-tgctagtatcaatacctlitctggctaagaagtcatatgtggtattcactatatcaglittaactggtagttccattag cctttcc acttctgcagaataatcagaaattggttctttaccagaaaatccagctactataataggctcaccgatgatcattggca a aatcctatattgtaccagattaatgagagcatatttcatttccaataattctgctagttcttgagacattgatttattt gatgaat ctagttggttctctagatactctaccatttctgccgcatacaataacttgttagataaaatcagggttatcaaagtgtt tagc gtggctagaatagtgggcttgcatgtattaaagaatgcggtagtatgagtaaaccgttttaacgaattatatagtctcc ag aaatctgtggcgttacatacatgagccgaatgacatcgaagattgtccaatatttttaatagctgctctttgtccatta tttct atatttgactcgcaacaattgtagataccattaatcactgattcctttttcgatgccggacaatagcacaattgtttag ctttg gactctatgtattcagaattaatagatatatctctcaatacagattgcactatacattttgaaactatgtcaaaaattg taga acgacgctgttctgcagccatttaactttaaataatttacaaaaatttaaaatgagcatccgtataaaaatcgataaac tg cgccaaattgtggcatatttttcagagttcagtgaagaagtatctataaatgtagactcgacggatgagttaatgtata tttt tgccgccttgggcggatctgtaaacatttgggccattatacctctcagtgcatcagtgttctaccgcggagccgaaaac attgtgtttaatcttcctgtgtccaaggtaaaatcgtgtttgtgtaglittcacaatgatgccatcatagatatagaac ctgatc tggaaaataatctagtaaaactttctagttatcatgtagtaagtgtcgattgtaacaaggaactgatgcctattaggac ag atactactatttgtctaagtatagatcaaaagaaatcttacgtgtttaattttcacaagtatgaagaaaaatgttgtgg tag aaccgtcattcatttagaatggttgttgggctttatcaagtgtattagtcagcatcagcatttggctattatgtttaaa gatga caatattattatgaagactcctggtaatactgatgcgttttccagggaatattctatgactgaatgttctcaagaacta caa aagttttctttcaaaatagctatctcgtctctcaacaaactacgaggattcaaaaagagagtcaatgttlitgaaacta ga atcgtaatggataatgacgataacattctaggaatgligttttcggatagagttcaatcctttaagatcaacatcttta tgac gtttttagattaatactttcaatgagataaatatgggtggcagagtaagtgttgagctccctaaacgggatccgcctcc gg gagtacccactgatgagatgttattaaacgtggataaaatgcatgacgtgatagctcccgctaagctlitagaatatgt g catataggaccactagcaaaagataaagaggataaagtaaagaaaagatatccagagtttagattagtcaacaca ggacccggtggtctttcggcattgttaagacaatcgtataatggaaccgcacccaattgctgtcgcacttttaatcgta ct cattattggaaaaaggatggaaagatatcagataagtatgaagagggtgcagtattagaatcgtgttggccagacgtt cacgacactggaaaatgcgatgttgatttattcgactggtgtcagggggatacgttcgatagaaacatatgccatcagt ggatcggttcagcctttaataggagtgatagaactgtagagggtcaacaatcgttaataaatctgtataataagatgca aacattatgtagtaaagatgctagtgtaccaatatgtgaatcattlitgcatcatttacgcgcacacaatacagaagat a gcaaagagatgatcgattatattctaagacaacagtctgcggactttaaacagaaatatatgagatgtagttatcccac tagagataagttagaagagtcattaaaatatgcggaacctcgagaatgligggatccagagtgttcgaatgccaatgtt aatttcttactaacacgtaattataataatttaggactttgcaatattgtacgatgtaatactagcgtgaacaacttac agat ggataaaacttcctcattaagattgtcatgtggattaagcaatagtgatagattttctactgttcccgtcaatagagca aa agtagttcaacataatattaaacattcgttcgacctaaaattgcatttgatcagtttattatctctcttggtaatatgg atacta attgtagctatttaaatgggtgccgcggcaagcatacagacgacggtgaatacactcagcgaacgtatctcgtctaaa ttagaacaagaagcgaacgctagtgctcaaacaaaatgtgatatagaaatcggaaatttttatatccgacaaaacca tggatgtaacctcactgttaaaaatatgtgctctgcggacgcggatgctcagttggatgctgtgttatcagccgctaca g

-79-aaacatatagtggattaacaccggaacaaaaagcatacgtaccagctatgtttactgctgcgttaaacattcagacga gtgtaaacactgttgttagagattttgaaaattatgtgaaacagacttgtaattctagcgcggtcgtcgataacaaatt aa agatacaaaacgtaatcatagatgaatgttacggagccccaggatctccaacaaatttggaatttattaatacaggatc tagcaaaggaaattgtgccattaaagcgttgatgcaattgacgactaaggccactactcaaatagcacctagacaag ttgctggtacaggagttcagttttatatgattgttatcggtgttataatattggcagcgttgtttatgtactatgccaa gcgtatg ttgttcacatccaccaatgataaaatcaaacttattttagccaataaggaaaacgtccattggactacttacatggaca c attctttagaacttctccgatggttattgctaccacggatatgcaaaactgaaaatatattgataatattttaatagat taac atggaagttatcgctgatcgtctagacgatatagtgaaacaaaatatagcggatgaaaaatttgtagattttgttatac ac ggtctagagcatcaatgtcctgctatacttcgaccattaattaggttgtttattgatatactattatttgttatagtaa tttatatttt tacggtacgtctagtaagtagaaattatcaaatgttgttggcgttggtggcgctagtcatcacattaactattttttat tacttt atactataatagtactagactgacttctaacaaacatctcacctgccataaataaatgcttgatattaaagtcttctat ttct aacactattccatctgtggaaaataatactctgacattatcgctaattgacacatcggtgagtgatatgcctataaagt aa taatcttctttgggcacatataccagtgtaccaggttctaacaacctatttactggtgctcctgtagcatactttttct ttacctt gagaatatccatcgtttgcttggtcaatagcgatatgtgattttttatcaaccactcaaaaaagtaattggagtgttca tatc ctctacgggctattgtctcatggccgtgtatgaaatttaagtaacacgactgtggtagatttgttctatagagccggtt gcc gcaaatagatagaactaccaatatgtctgtacaaatgttaaacattaattgattaacagaaaaaacaatglicgttctg g gaatagaaaccagatcaaaacaaaattcgttagaatatatgccacgtttatacatggaatataaaataactacagtttg aaaaataacagtatcatttaaacatttaacttgcggggttaatttcacaactttactgtttttaaactgttcaaaatat agcat cgatccatgagaaatacgtttagccgcctttaatagaggaaatcccaccgcctttctggatctcaccaacgacgatagt tctgaccagcaacttatttcttcatcatccacctgttttaacatataataggcaggagatagatatccgtcattgcaat attc cttttcgtaggcacacaatctaatattgataaaatctccattctcttctctgcatttattatcttgtttcggtggctga ttaggctg tagtcttggtttaggctttggtatatcgttgttgaatctattttggtcattaaatctttcatttcttcctggtatattt ctatcacctcgtt tggttggattlitgtctatattatcgtttgtaacatcggtacgggtattcatttatcacaaaaaaaacttctctaaatg agtcta ctgctagaaaacctcatcgaagaagataccatattttttgcaggaagtatatctgagtatgatgatttacaaatggtta ttg ccggcgcaaaatccaaatttccaagatctatgctttctatlittaatatagtacctagaacgatgtcaaaatatgagtt gga gttgattcataacgagaatatcacaggggcaatgtttaccacaatgtataatataagaaacaatttgggtctaggagat gataaactaactattgaagccattgaaaactatttcttggatcctaacaatgaggttatgcctcttatcattaataata cgg atatgactgccgtcattcctaaaaaaagtggtaggagaaagaataagaacatggttattttccgtcaaggatcatcacc tatcttgtgtattlicgaaactcgtaaaaagattaatatttataaagaaaatatggaatccgcgtcgactgagtataca cct atcggagacaacaaggctttgatatctaaatatgcgggaattaatgtcctgaatgtgtattctccttccacatccatga ga ttgaatgccatttacggattcaccaataaaaataaactagagaaacttagtactaataaggaactagaatcgtatagtt ctagccctcttcaagaacccattaggttaaatgattttctgggactattggaatgtgttaaaaagaatattcctctaac aga tattccgacaaaggattgattactataaatggagaatgttcctaatgtatactttaatcctgtgtttatagagcccacg ttta aacattctttattaagtgtttataaacacagattaatagttttatttgaagtattcattgtattcattctaatatatgt attttttagat

-80-ctgaattaaatatgttclicatgcctaaacgaaaaatacccgatcctattgatagattacgacgtgctaatctagcgtg tg aagacgataaattaatgatctatggattaccatggatgacaactcaaacatctgcgttatcaataaatagtaaaccgat agtgtataaagattgtgcaaagclittgcgatcaataaatggatcacaaccagtatctcttaacgatgttcttcgcaga tg atgattcattttttaagtatttggctagtcaagatgatgaatcttcattatctgatatattgcaaatcactcaatatct agacttt ctgttattattattgatccaatcaaaaaataaattagaagccgtgggtcattgttatgaatctctttcagaggaataca gac aattgacaaaattcacagactttcaagattttaaaaaactgtttaacaaggtccctattgttacagatggaagggtcaa a cttaataaaggatatttgttcgactttgtgattagtttgatgcgattcaaaaaagaatcctctctagctaccaccgcaa tag atcctattagatacatagatcctcgtcgcgatatcgcattttctaacgtgatggatatattaaagtcgaataaagtgaa ca ataattaattctttattgtcatcatgaacggcggacatattcagttgataatcggccccatgttttcaggtaaaagtac aga attaattagacgagttagacgttatcaaatagctcaatataaatgcgtgactataaaatattctaacgataatagatac g gaacgggactatggacgcatgataagaataattttgaagcattggaagcaactaaactatgtgatgtcttggaatcaat tacagatttctccgtgataggtatcgatgaaggacagttctttccagacattgttgaattctgtgagcgtatggcaaac ga aggaaaaatagttatagtagccgcactcgatgggacatttcaacgtaaaccgtttaataatattttgaatcttattcca tta tctgaaatggtggtaaaactaactgctgtgtgtatgaaatgctttaaggaggcttccttttctaaacgattgggtgagg aa accgagatagagataataggaggtaatgatatgtatcaatcggtgtgtagaaagtgttacgtcggctcataatattata t thttatctaaaaaactaaaaataaacattgattaaattttaatataatacttaaaaatggatgttgtgtcgttagataa acc gtttatgtattttgaggaaattgataatgagttagattacgaaccagaaagtgcaaatgaggtcgcaaaaaaactgccg tatcaaggacagttaaaactattactaggagaattattttttcttagtaagttacagcgacacggtatattagatggtg cca ccgtagtgtatataggatctgctcccggtacacatatacgttatttgagagatcatttctataatttaggagtgatcat caaa tggatgctaattgacggccgccatcatgatcctattttaaatggattgcgtgatgtgactctagtgactcggttcgttg atga ggaatatctacgatccatcaaaaaacaactgcatccttctaagattattttaatttctgatgtgagatccaaacgagga g gaaatgaacctagtacggcggatttactaagtaattacgctctacaaaatgtcatgattagtattttaaaccccgtggc gt ctagtcttaaatggagatgcccgtttccagatcaatggatcaaggacttttatatcccacacggtaataaaatgttaca a ccttttgctccttcatattcagctgaaatgagattattaagtatttataccggtgagaacatgagactgactcgagtta cca aatcagacgctgtaaattatgaaaaaaagatgtactaccttaataagatcgtccgtaacaaagtagttgttaactttga tt atcctaatcaggaatatgactattttcacatgtactttatgctgaggaccgtgtactgcaataaaacatttcctactac taa agcaaaggtactatttctacaacaatctatatttcgtttcttaaatattccaacaacatcaactgaaaaagttagtcat gaa ccaatacaacgtaaaatatctagcaaaaattctatgtctaaaaacagaaatagcaagagatccgtacgcagtaataa atagaaacgtactactgagatatactaccgatatagagtataatgatttagttactttaataaccgttagacataaaat tg attctatgaaaactgtgtttcaggtatttaacgaatcatccataaattatactccggttgatgatgattatggagaacc aat cattataacatcgtatcttcaaaaaggtcataacaagtttcctgtaaattttctatacatagatgtggtaatatctgac ttattt cctagctttgttagactagatactacagaaactaatatagttaatagtgtactacaaacaggcgatggtaaaaagactc ttcgtcttcccaaaatgttagagacggaaatagttgtcaagattctctaccgtcctaatataccattaaaaattgttag atttt tccgcaataacatggtaactggagtagagatagccgatagatctgttatttcagtcgctgattaatcaattagtagaga t

-81-gagataagaacattataataatcaataatatattttatatcttatatcttgtttagaaaaatgctaatattaaaatagc taac gctagtaatccaatcggaagccatttgatatctataatagggtatctaatttcctgattcagatagcggacagctatat tct cggtagctactcgtttggaatcacaaacattatttacatctaatttactatctgtaatggaaacgtttcccaatgaaat ggta caatccgatacattgcattttgttatatttthtttaaagaggctggtaacaacgcatcgcttcgtttacatggctcgta ccaa caataatagggtaatcttgtatctattcctatccgtactatgclittatcaggataaatacatttacatcgtatatcgt ctttgtta gcatcacagaatgcataaatttgttcgtccgtcatgataaaaatttaaagtgtaaatataactattattttatagttgt aataa aaagggaaatttgattgtatactttcggttctttaaaagaaactgacttgataaaaatggctgtaatctctaaggttac gtat agtctatatgatcaaaaagagattaatgctacagatattatcattagtcatgttaaaaatgacgacgatatcggtaccg tt aaagatggtagactaggtgctatggatggggcattatgtaaaacttgtgggaaaacggaattggaatgtttcggtcact ggggtaaagtaagtatttataaaactcatatagttaagcctgaatttatttcagaaattattcgtttactgaattatat atgtat tcactgcggattattgcgttcacgagaaccgtattccgacgatattaacctaaaagagttatcgggacacgctcttagg agattaaaggataaaatattatccaagaaaaagtcatgttggaacagtgaatgtatgcaaccgtatcaaaaaattactt tttcaaagaaaaaggtligtttcgtcaacaagttggatgatattaacgttcctaattctctcatctatcaaaagttaat ttctat tcatgaaaagttttggccattattagaaattcatcaatatccagctaacttattttatacagactactttcccatccct ccgttg attattagaccggctattagtttttggatagatagtatacccaaagaaaccaatgaattaacttacttattaggtatga tcgt taagaattgtaacttgaatgctgatgaacaggttatccagaaggcggtaatagaatacgatgatattaaaattatttct a ataacacttccagtatcaatttatcatatatcacatccggcaaaaataatatgattagaagttatatcgtcgcccggcg a aaagatcagaccgctagatctgtaattggtcccagtacatctatcaccgttaatgaggtaggaatgcccgcatatatta gaaatacacttacagaaaagatatttgttaatgcctttacagtggataaagttaaacaactattagcgtcaaaccaagt t aaattttactttaataaacgattaaaccaattaacaagaatacgccaaggaaagtttatcaaaaataaaatacatttat t gcctggtgattgggtagaagtagctgttcaagaatatacaagtattatttttggaagacagccgtctctacatagatac a acgtcatcgcttcatctatcagagctaccgaaggagatactatcaaaatatctcccggaattgtcaactctcaaaatgc t gatttcgacggagatgaagaatggatgatattggagcaaaatcctaaagccgtaattgaacaaagtattcttatgtatc cgacgacgttactcaaacacgatattcatggagcccccgtttatggatctattcaagatgaaatcgtagcagcgtattc a ttgtttaggatacaagatctttgtttagatgaagtattgaacatcttggggaaatatggaagagagttcgatcctaaag gt aaatgtaaattcagcggtaaagatatctatacttacttgataggtgaaaagattaattatccgggtctcttaaaggatg gt gaaattattgcaaacgacgtagatagtaattttgttgtggctatgaggcatctgtcattggctggactcttatccgatc ata agtcgaacgtggaaggtatcaactttattatcaagtcatcttatgtlittaagagatatctatctatttacggttttgg ggtgac attcaaagatctgagaccaaattcgacgttcactaataaattggaggccatcaacgtagaaaaaatagaacttatcaa agaagcatacgccaaatatctcaacgatgtaagagacgggaaaatagttccattatctaaagctttagaggcggact atgtggaatccatgttatccaacttgacaaatcttaatatccgagagatagaagaacatatgagacaaacgctgatag atgatccagataataacctcctgaaaatggccaaagcgggttataaagtaaatcccacagaactaatgtatattctag gtacttatggacaacagaggattgatggtgaaccagcagagactcgagtattgggtagagtcttaccttactatcttcc a gactctaaggatccagaaggaagaggttacattcttaattctttaacaaaaggattaacgggttctcaatattactttt cg

-82-atgctggttgcaagatctcaatctactgatatcgtctgtgaaacatcacgtaccggaacactggctagaaaaatcatta aaaagatggaggatatggtggtcgacggatacggacaagtagttataggtaatacgctcatcaagtacgccgccaa ttataccaaaattctaggctcagtatgtaaacctgtagatcttatctatccagatgagtccatgacttggtatttggaa atta gtgctctgtggaataaaataaaacagggattcgtttactctcagaaacagaaacttgcaaaaaagacattggcgccgt ttaatttcctagtattcgtcaaacccaccactgaggataatgctattaaggttaaggatctgtacgatatgattcataa cgt cattgatgatgtgagagagaaatacttctttacggtatctaatatagattttatggagtatatattcttgacgcatctt aatcct tctagaattagaattacaaaagaaacggctatcactatctttgaaaagttctatgaaaaactcaattatactctaggtg gt ggaactcctattggaattatttctgcacaggtattgtctgagaagtttacacaacaagccctgtccagttttcacacta ctg aaaaaagtggtgccgtcaaacaaaaacttggtttcaacgagtttaataacttgactaatttgagtaagaataagaccg aaattatcactctggtatccgatgatatctctaaacttcaatctgttaagattaatttcgaatttgtatgtligggaga attaaa tccaaacatcactcttcgaaaagaaacagataggtatgtagtagatataatagtcaatagattatacatcaagagagc agaaattaccgaattagtcgtcgaatatatgattgaacgattcatctcctttagcgtcattgtaaaggaatggggtatg ga aacattcattgaggatgaggataatattagatttactgtctacctaaatttcgttgaaccggaagaattgaatcttagt aag tttatgatggttcttccgggtgccgccaacaagggcaagattagtaaattcaagattcctatctctgattatacgggat atg acgacttcaatcaaacaaaaaagctcaataagatgactgtagaactcatgaatctaaaagaattgggttctttcgattt ggaaaacgtcaacgtgtatcctggagtatggaatacatacgatatcttcggtatcgaggccgctcgtgaatacttgtgc gaagccatgttaaacacctatggagaagggttcgattatctgtatcagccttgtgatcttctcgctagtttactatgtg ctag ttacgaaccagaatcagtgaataaattcaagttcggcgcagctagtactcttaagagagctacgttcggagacaataa agcattgttaaacgcggctcttcataaaaagtcagaacctattaacgataatagtagctgccacttttttagcaaggtc c ctaatataggaactggatattacaaatactttatcgacttgggtcttctcatgagaatggaaaggaaactatctgataa g atatcttctcaaaagatcaaggaaatggaagaaacagaagacttttaattcttatcaataacatatttttctatgatct gtct tttaaacgatggattttccacaaatgcgcctctcaagtccctcatagaatgatacacgtataaaaaatatagcataggc aatgactccttattlitagacattagatatgccaaaatcatagccccgcttctatttactcccgcagcacaatgaacca ac acgggctcgtttcgttgatcacatttagataaaaaggcggttacgtcgtcaaaatatttactaatatcggtagttgtat catc taccaacggtatatgaataatattaatattagagttaggtaatgtatatttatccatcgtcaaatttaaaacatatttg aactt aacttcagatgatggtgcatccatagcatttttataatttcccaaatacacattattggttactcttgtcattatagtg ggagat ttggctttgtgcatatctccagttgaacgtagtagtaagtatttatacaaacttttcttatccatttataacgtacaaa tggata aaactactttatcggtaaacgcgtgtaatttagaatacgttagagaaaaggctatagtaggcgtacaagcagccaaa acatcaacacttatattclitgttattatattggcaattagtgcgctattactctggtttcagacgtctgataatccag tctttaat gaattaacgagatatatgcgaattaaaaatacggttaacgattggaaatcattaacggatagcaaaacaaaattaga aagtgatagaggtagacttctagccgctggtaaggatgatatattcgaattcaaatgtgtggatttcggcgcctatttt ata gctatgcgattggataagaaaacatatctgccgcaagctattaggcgaggtactggagacgcgtggatggttaaaaa ggcggcaaaggtcgatccatctgctcaacaattttgtcagtatttgataaaacacaagtctaataatgttattacttgt ggt aatgagatgttaaatgaattaggttatagcggttattttatgtcaccgcattggtgttccgattttagtaatatggaat agtgtt

-83-agataaatgcggtaacgaatgttcctgtaaggaaccataacagcttagatttaacgttaaagatgagcataaacataa taaacaaaattacaatcaaacctataacattaatatcaaacaatccaaaaaatgaaatcagtggagtagtaaacgc gtacataactcctggataacgtttagcagctgccgttcctattctagaccaaaaattcggtttcatgttttcgaaacgg tatt ctgcaacaagtcgaggatcgtgttctacatatttggcggcgttatccagtatctgcctattgatcttcatttcgttttc gattctg gctatttcaaaataaaatcccgatgatagacctccagactttataatttcatctacgatgttcagcgccgtagtaactc taa taatataggctgataagctaacatcataccctcctgtatatgtgaatatggcatgatttttgtccattacaagctcggt tttaa ctttattgcctgtaataatttctctcatctgtaggatatctatttttttgtcatgcattgccttcaagacgggacgaag aaacgt aatatcctcaataacgttatcgttttctacaataactacatattctacctttttattttctaactcggtaaaaaaatta gaatcc catagggctaaatgtctagcgatatttcttttcgtttcctctgtacacatagtgttacaaaaccctgaaaagaagtgag tat acttgtcatcatttctaatglitcctccagtccactgtataaacgcataatccttgtaatgatctggatcatccttgac tacca caacatttcttttttctggcataacttcattgtcctttacatcatcgaacttctgatcattaatatgctcatgaacatt aggaaat gtttctgatggaggtctatcaataactggcacaacaataacaggagtlitcaccgccgccatttagttattgaaattaa tc atatacaactctttaatacgagttatattttcgtctatccattgtttcacatttacatatttcgacaaaaagatataaa atgcgt attccaatgcttctctglitaatgaattactaaaatatacaaacacgtcactgtctggcaataaatgatatcttagaat attgt aacaatttattttgtattgcacatglicgtgatctatgagttcttcttcgaatggcataggatctccgaatctgaaaac gtata aataggagttagaataataatatttgagagtattggtaatatataaactctttagcggtataattagtttttttctctc gatttct atttttagatgtgatggaaaaatgactaattttgtagcattagtatcatgaactctaatcgagatcttaatatcttcgt cacac gttagttctttgaagtttttaagagatgcatcagttggttcgaccgatggagtaggtgcaacaattttttgttcgatgt atgtat gtactggagccattgtcttaactataatggtgcttgtatcgaaaaactttaatgcagataatggaagctcttcgccgcg ac tttctacatcgtaattgggttctaacgccgatctctgaatggatactagttttctaagttctaatgtgattctctgaaa atgtaa atccaattcctccggcattatagatgtgtatacatcggtaaataaaactatagtatccaacgatcccttctcgcaaatt cta gtcttaaccaaaaaatcgtatataaccacggagatggcgtatttaagagtggattcttctaccgttligttcttggatt tcata taagaaactataaagtccgcactactgttaagaatgattactaacgcaactatatagtttaaattaagcatcttggaaa c ataaaataactctgtagacgatacttgactttcgaataagtttgcagacaaacgaagaaagaacagacctctcttaatt t cagaagaaaactlittttcgtattcctgacgtctagagtttatatcaataagaaagttaagaattagtcggttaatgtt gtattt cattacccaagtttgagatttcataatattatcaaaagacatgataatattaaagataaagcgctgactatgaacgaaa t agctatatggttcgctcaagaatatagtcttgttaaacgtggaaacgataactgtatttttaatcacgtcagcggcatc taa attaaatataggtatatttattccacacactctacaatatgccacaccatcttcataataaataaattcgttagcaaaa ttat taattttagtgaaatagttagcgtcaactttcatagcttccttcaatctaatttgatgctcacacggtgcgaattccac tctaa catcccttttccatgcctcaggttcatcgatctctataatatctagttttttgcgtttcacaaacacaggctcgtctct cgcgat gagatctgtatagtaactatgtaaatgataactagatagaaagatgtagctatatagatgacgatcctttaagagaggt atgatgactttaccccaatcagatagactgttgttatggtcttcggaaaaagaatttttataaattlitccagtatttt ccaaat atacgtacttaacatctaaaaaatccttaatgataataggaatggataatccgtctattttataaagaaatacatatcg ca cattatacttttttttggaaatgggaataccgatgtgtctacataaatatgcaaagtctaaatattttttagagaatct tagttg

-84-gtccaaattcttttccaagtacggtaatagatttttcatattgaacggtatclicttaatctctggttctagttccgca ttaaatg atgaaactaagtcactatttttataactaacgattacatcacctctaacatcatcatttaccagaatactgatcttctt ttgtcg taaatacatgtctaatgtgttaaaaaaaagatcatacaagttatacgtcatttcatctgtggtattcttgtcattgaag gata aactcgtactaatctcttctttaacagcctgttcaaatttatatcctatatacgaaaaaatagcaaccagtgtttgatc atcc gcgtcaatattctgttctatcgtagtgtataacaatcgtatatcttcttctgtgatagtcgatacgttataaaggttga taacg aaaatatttttatttcgtgagataaagtcatcgtaggattttggacttatattcgcgtctagtagatatgcttttattt ttggaatg atctcaattagaatagtctctttagagtccatttaaagttacaaacaactaggaaattggtttatgatgtataatttht tagtttt tatagattctttattctatacttaaaaaatgaaaataaatacaaaggttcttgagggttgtgttaaattgaaagcgaga aat aatcataaattatttcattatcgcgatatccgttaagtttgtatcgtaatggcgtggtcaattacaaataaagcggata cta gtagcttcacaaagatggctgaaatcagagctcatctaaaaaatagcgctgaaaataaagataaaaacgaggatat tttcccggaagatgtaataattccatctactaagcccaaaaccaaacgagccactactcctcgtaaaccagcggctac taaaagatcaaccaaaaaggaggaagtggaagaagaagtagttatagaggaatatcatcaaacaactgaaaaa aattctccatctcctggagtcagcgacattgtagaaagcgtggctgctgtagagctcgatgatagcgacggggatgat gaacctatggtacaagttgaagctggtaaagtaaatcatagtgctagaagcgatctttctgacctaaaggtggctaccg acaatatcgttaaagatcttaagaaaattattactagaatctctgcagtatcgacggttctagaggatgttcaagcagc t ggtatctctagacaatttacttctatgactaaagctattacaacactatctgatctagtcaccgagggaaaatctaaag tt gttcgtaaaaaagttaaaacttgtaagaagtaaatgcgtgcacttttttataaagatggtaaactctttaccgataata attt tttaaatcctgtatcagacgataatccagcgtatgaggttttgcaacatgttaaaattcctactcatttaacagatgta gtag tatatgaacaaacgtgggaggaggcgttaactagattaatttttgtgggaagtgattcaaaaggacgtagacaatactt ttacggaaaaatgcatgtacagaatcgcaacgctaaaagagatcgtatttttgttagagtatataacgttatgaaacga attaattgttttataaacaaaaatataaagaaatcgtccacagattccaattatcagttggcggtttttatgttaatgg aaac tatgttttttattagatttggtaaaatgaaatatcttaaggagaatgaaacagtagggttattaacactaaaaaataaa ca catagaaataagtcccgatgaaatagttatcaagtttgtaggaaaggacaaagtttcacatgaatttgttgttcataag tc taatagactatataaaccgctattgaaactgacggatgattctagtcccgaagaatttctgttcaacaaactaagtgaa c gaaaggtatacgaatgtatcaaacagtttggtattagaatcaaggatctccgaacgtatggagtcaattatacgttttt at ataatttttggacaaatgtaaagtccatatctcctcttccgtcaccaaaaaagttaatagcgttaactatcaaacaaac tg ctgaagtggtaggtcatactccatcaatttcaaaaagagcttatatggcaacgactattttagaaatggtaaaggataa aaattttttagatgtagtatctaaaactacgttcgatgaattcctatctatagtcgtagatcacgttaaatcatctacg gatg gatgatatagatctttacacaaataattacaagaccgataaatggaaatggataagcgtatgaaatctctcgcaatga cagctttcttcggagagctaaacacattagatattatggcattgataatgtctatatttaaacgccatccaaacaatac ca thtttcagtggataaggatggtcagtttatgattgatttcgaatacgataattataaggcttctcaatatttggatctg accct cactccgatatctggagatgaatgcaagactcacgcatcgagtatagccgaacaattggcgtgtgtggatattattaaa gaggatattagcgaatatatcaaaactactccccgtcttaaacgatttataaaaaaataccgcaatagatcagatactc gtatcagtcgagatacagaaaagcttaaaatagctctagctaaaggcatagattacgaatatataaaagacgcligtt

-85-aataagtaaatgaaaaaaaactagtcgtttataataaaacacaatatggatgccaacatagtatcatcttctactattg c aacgtatatagacgctttagcgaagaatgcttcagaattagaacagaggtctaccgcatacgaaataaataatgaatt ggaactagtatttattaagccgccattaattactttgacaaatgtagtgaatatctctacgattcaggaatcgtttatt cgatt taccgttactaataaggaaggtgttaaaattagaactaagattccattatctaaggtacatggtctagatgtaaaaaat gt acagttagtagatgctatagataacatagtttgggaaaagaaatcattagtgacggaaaatcgtcttcacaaagaatg cttgttgagactatcgacagaggaacgtcatatatttttggattacaagaaatatggatcctctatccgactagaatta gtc aatcttattcaagcaaaaacaaaaaactttacgatagactttaagctaaaatattttctaggatccggtgcccagtcta a aagttctttattacacgctattaatcatccaaagtcaaggcctaatacatctctggaaatagaattcacacctagagac a atgaaaaagttccatatgatgaactaataaaggaattgacgactctatcacgtcatatatttatggcttctccagagaa t gtaattclitctccgcctattaacgcgcctataaaaacctttatgttgcctaaacaagatatagtaggtttggatctgg aaa atctatatgccgtaactaagactgacggaattcctataactatcagagttacatcaaaagggttgtattgttattttac acat cttggttatattattagatatcctgttaagagaataatagattccgaagtagtagtctttggtgaggcagttaaggata aga actggaccgtatatctcattaagctaatagagcctgtgaatgcaatcaatgatagactagaagaaagtaagtatgttga atctaaactagtggatatttgtgatcggatagtattcaagtcaaagaaatacgaaggtccgtttactacaactagtgaa g tcgtcgatatgttatctacatatttaccaaagcaaccagaaggtgttattctgttctattcaaagggacctaaatctaa catt gattttaaaattaaaaaggaaaatactatagaccaaactgcaaatgtagtatttaggtacatgtccagtgaaccaatta t ctttggagaatcgtctatctttgtagagtataagaaatttagcaacgataaaggclitcctaaagaatatggttctggt aag attgtgttatataacggcgttaattatctaaataatatctattgtttggaatatattaatacacataatgaagtgggta ttaagt ccgtggttgtacctattaagtttatagcagaattcttagttaatggagaaatacttaaacctagaattgataaaaccat ga aatatattaactcagaagattattatggaaatcaacataatatcatagtcgaacatttaagagatcaaagcatcaaaat aggagatatctttaacgaggataaactatcggatgtgggacatcaatacgccaataatgataaatttagattaaatcca gaagttagttattttacgaataaacgaactagaggaccgttgggaattttatcaaactacgtcaagactclicttattt ctat gtattgttccaaaacatttttagacgattccaacaaacgaaaggtattggcgattgattttggaaacggtgcggacctg g aaaaatacttttatggagagattgcgttattggtagcgacggatccggatgctgatgctatagctagaggaaatgaaag atacaacaaattaaactctggaattaaaaccaagtactacaaatttgactacattcaggaaactattcgatccgataca tttgtctctagtgtcagagaagtattctattttggaaagtttaatatcatcgactggcagtttgctatccattattctt ttcatccg agacattatgctaccgtcatgaataacttatccgaactaactgcttctggaggcaaggtattaatcactaccatggacg gagacaaattatcaaaattaacagataaaaagacttttataattcataagaatttacctagtagcgaaaactatatgtc t gtagaaaaaatagctgatgatagaatagtggtatataatccatcaacaatgtctactccaatgactgaatacattatca aaaagaacgatatagtcagagtgtttaacgaatacggatttgttcttgtagataacgttgatttcgctacaattataga ac gaagtaaaaagtttattaatggcgcatctacaatggaagatagaccgtctacaaaaaactttttcgaactaaatagag gagccattaaatgtgaaggtttagatgtcgaagacttacttagttactatgttgtttatgtclittctaagcggtaaat aataat atggtatgggttctgatatccccgttctaaatgcattaaataattccaatagagcgatttttgttcctataggaccttc caact gtggatactctgtattgttaatagatatattaatacttttgtcgggtaacagagglictacgtcttctaaaaataaaag tttgat

-86-aacatctggcctgttcataaataaaaacttggcgattctatatatactcttattatcaaatctagccattgtcttatag atgtg agctactgtaggtgtaccatttgattttctttctaatactatatatttctctcgaagaagttcttgcacatcatctggg aataaa atactactgttgagtaaatcagttattttttttatatcgatattgatggacatttttatagttaaggataataagtatc ccaaagt cgataacgacgataacgaagtatttatacttttaggaaatcacaatgactttatcagatcaaaattaacaaaattaaag gagcatgtatttttttctgaatatattgtgactccagatacatatggatctttatgcgtcgaattaaatgggtctagtt ttcagc acggtggtagatatatagaggtggaggaatttatagatgctggaagacaagttagatggtgttctacatccaatcatat atctgaagatatgcacactgataaatttgtcatttatgatatttatacgtttgattcgttcaagaataaacgattggta tttgta caggtgcctccatcattaggagatgatagctatttgactaatccgttattgtctccgtattatcgtaattcagtagcca gac aaatggtcaatgatatgatttttaatcaagattcatttttaaaatatttattagaacatctgattagaagccactatag agtttc taaacatataacaatagttagatacaaggataccgaagaattaaatctaacgagaatatgttataatagagataagttt aaggcgtttgtattcgcttggtttaacggcgtttcggaaaatgaaaaggtactagatacgtataaaaaggtatctaatt tg atataatgaattcagtgactgtatcacacgcgccatatactattacttatcacgatgattgggaaccagtaatgagtca at tggtagagttttataacgaagtagccagttggctgctacgagacgagacgtcgcctattcctgataagttctttataca gtt gaaacaaccgcttagaaataaacgagtatgtgtgtgtggtatagatccgtatccgaaagatggaactggtgtaccgtt cgaatcaccaaattttacaaaaaaatcaattaaggagatagcttcatctatatctagattaaccggagtaattgattat a aaggttataaccttaatataatagacggggttataccctggaattattacttaagttgtaaattaggagaaacaaaaag t cacgcgatctactgggataagatttccaagttactgctgcagcatataactaaacacgttagtgttctttattgtttgg gtaa aacagatttctcgaatatacgggcaaagttagaatccccggtaactaccatagtcggatatcatccagcggctagag accgccaattcgagaaagatagatcatttgaaattatcaacgttttactggaattagacaacaaggcacctataaattg ggctcaagggtttatttattaatgctttagtgaaattttaacttgtgttctaaatggatgcaactattagaggtaatga tgttat ctttglicttaagactataggtgtcccgtcagcgtgcagacaaaatgaagatccaagatttgtagaagcatttaaatgc g acgagttagaaagatatattgagaataatccagaatgtacactattcgaaagtcttagggatgaggaagcatactctat agtcagaattttcatggatgtagatttagacgcgtgtctagacgaaatagattatttaacggctattcaagattttatt atcg aggtgtcaaactgtgtagctagattcgcgtttacagaatgcggtgccattcatgaaaatgtaataaaatccatgagatc t aatttttcattgactaagtctacaaatagagataaaacaagttttcatattatctttttagacacgtataccactatgg atac attgatagctatgaaacgaacactattagaattaagtagatcatctgaaaatccactaaccagatcgatagacactgc cgtatataggagaaaaacaactcttcgggttgtaggtactaggaaaaatccaaattgcgacactattcatgtaatgca accaccgcatgataatatagaagattacctattcacttacgtggatatgaacaacaatagttattacttttctctacaa cg acgattggaggatttagttcctgataagttatgggaaccagggtttatttcattcgaagacgctataaaaagagtttca aa aatattcattaattctataataaactttaatgatctcgatgaaaataattttacaacggtaccactggtcatagattac gtaa caccttgtgcattatgtaaaaaacgatcgcataaacatccgcatcaactatcgttggaaaatggtgctattagaattta c aaaactggtaatccacatagttgtaaagttaaaattgttccgttggatggtaataaactgtttaatattgcacaaagaa tttt agacactaactctgttttattaaccgaacgaggagaccatatagtttggattaataattcatggaaatttaacagcgaa g aacccttgataacaaaactaattctgtcaataagacatcaactacctaaggaatattcaagcgaattactctgtccgag

-87-gaaacgaaagactgtagaagctaacatacgagacatgttaatagattcagtggagaccgatacctatccggataaa cttccgtttaaaaatggtgtattggacctggtagacggaatgttttactctggagatgatgctaaaaaatatacgtgta ctg tatcaaccggatttaaatttgacgatacaaagttcgtcgaagacagtccagaaatggaagagttaatgaatatcattaa cgatatccaaccattaacggatgaaaataagaaaaatagagagttgtacgaaaaaactttatctagttgthatgcggt gctaccaaaggatgtttaacattcttttttggagaaactgcaactggaaagtcgacaaccaaacgtttgttaaagtctg ct atcggtgacctgthgttgagacgggtcaaacaattttaacagatgtattggataaaggacctaatccatttatcgctaa c atgcatttgaaaagatctgtattctgtagcgaactacctgattttgcctgtagtggatcaaagaaaattagatctgaca at attaaaaagttgacagaaccttgtgtcattggaagaccgtgtttctccaataaaattaataatagaaaccatgcgacaa tcattatcgatactaattacaaacctgtctttgataggatagataacgcattaatgagaagaattgccgtcgtgcgatt ca gaacacacttttctcaaccttctggtagagaggctgctgaaaataatgacgcgtacgataaagtcaaactattagacg aggggttagatggtaaaatacaaaataatagatatagattcgcatttctatacttgttggtgaaatggtacaaaaaata t catgttcctattatgaaactatatcctacaccggaagagattccggactttgcattctatctcaaaataggtactctgt tagt atctagctctgtaaagcatattccattaatgacggacctctccaaaaagggatatatattgtacgataatgtggttact ctt ccgttgactactttccaacagaaaatatccaagtattttaattctagactatttggacacgatatagagagcttcatca ata gacataagaaatttgccaatgttagtgatgaatatctgcaatatatattcatagaggatatttcatctccgtaaatata tgct catatatttatagaagatatcacatatctaaatgaataccggaatcatagatttatttgataatcatgttgatagtata ccaa ctatattacctcatcagttagctactctagattatctagttagaactatcatagatgagaacagaagcgtgttattgli ccat attatgggatcaggtaaaacaataatcgctttgttgttcgccttggtagcttccagatttaaaaaggtttacattctag tgcct aatattaacattttgaaaatttttaattataatatgggtgtagctatgaacttgtttaatgacgaattcatagctgaga atatct ttattcattccacaacaagtttttattctcttaattataacgataacgtcattaattataacggattatctcgctacaa taactct atttttatcgttgatgaggcacataatatctttgggaataatactggagaacttatgaccgtgataaaaaataaaaaca a gattccttttttactattgtctggatctcccattactaacacacctaatactctgggtcatattatagatttaatgtcc gaagag acgatagattttggtgaaattattagtcgtggtaagaaagtaattcagacacttcttaacgaacgaggtgtgaatgtac tt aaggatttgcttaaaggaagaatatcatattacgaaatgcctgataaagatctaccaacgataagatatcacggacgt aagtttctagatactagagtagtatattgtcacatgtctaaacttcaagagagagattatatgattactagacgacagc ta tgttatcatgaaatgtttgataaaaatatgtataacgtgtcaatggcagtattgggacaacttaatctgatgaataatt tag atactttatttcaggaacaggataaggaattgtacccaaatctgaaaataaataatggcgtgttatacggagaagaatt ggtaacgttaaacattagttccaaatttaaatactttattaatcggatacagacactcaacggaaaacattttatatac tttt ctaattctacatatggcggattggtaattaaatatatcatgctcagtaatggatattctgaatataatggttctcaggg aact aatccacatatgataaacggcaaaccaaaaacatttgctatcgttactagtaaaatgaaatcgtctttagaggatctat t agatgtgtataattctcctgaaaacgatgatggcagtcaattgatgtttttgttttcgtcaaacattatgtccgaatcc tatact ctgaaagaggtaaggcatatttggtttatgactatcccagatactttttctcaatacaaccaaattcttggacgatcta ttag aaaattctcttacgccgatatttctgaaccagttaatgtatatcttttagccgccgtatattccgatttcaatgacgaa gtga cgtcattaaacgattacacacaggatgaattaattaatgttttaccatttgacatcaaaaagctgttgtatctaaaatt taa

-88-gactaaagaaacgaatagaatatactctattcttcaagagatgtctgaaacgtattctcttccaccacatccatcaatt gt aaaagttttattgggagaattggtcagacaatttttttataataattctcgtattaagtataacgataccaagttactt aaaat ggttacatcagttataaaaaataaagaagacgctaggaattacatagatgatattgtaaacggtcacttctttgtatcg a ataaagtatttgataaatctcttttatacaaatacgaaaacgatattattacagtaccgtttagactttcctacgaacc atttg tttggggagttaactttcgtaaagaatataacgtggtatcttctccataaaactgatgagatatataaagaaataaatg tc gagctttgttaccaatggataccttccagttacattggagccacacgagctgacgttagacataaaaactaatattagg aatgccgtatataagacgtatctccatagagaaattagtggtaaaatggccaagaaaatagaaattcgtgaagacgt ggaattacctctcggcgaaatagttaataattctgtagttataaacgttccgtgtgtaataacctacgcgtattatcac gttg gggatatagtcagaggaacattaaacatcgaagatgaatcaaatgtaactattcaatgtggagatttaatctgtaaact aagtagagattcgggtactgtatcatttagcgattcaaagtactgcttttttcgaaatggtaatgcgtatgacaatggc ag cgaagtcactgccgttctaatggaggctcaacaaggtatcgaatctagttttgtlittctcgcgaatatcgttgactca taa aaaagagaatagcggtaagtataaacacgaatactatggcaataattgcgaatgttttattcccttcgatatatttttg ata atatgaaaaacatgtctctctcaaatcggacaaccatctcataaaatagttctcgcgcgctggagaggtagttgctgct c gtataatctccccagaataatatacttgcgtgtcgtcgttcaatttatacggatttctatagttctctgttatataatg cggttttc catcatgattagacgacgacaatagtgttctaaatttagatagttgatcagaatgaatglitattggcgttggaaaaat tat ccatacagcgtctgcagagtggttgatagttgttcctagatatgtaaaataatccaacttactaggcagcaaattgtct ag ataaaatactgaatcaaacggtgcagacgtattggtggatctaatggaatccaattgattaactatcttttgaaaatat ac atttttatgatccgatacttgtaagaatatagaaataatgataagtccatcatcgtgtttttttgcctcttcataagaa ctatatt ttttcttattccaatgaacaagattaatctctccagagtatttgtacacatctatcaagtgattggatccataatcgtc ttccttt ccccaatatatacgtagtgatgataacacatattcattggggagaaaccctccacttatatatcctcctttaaaattaa tcc ttactagttttccagtgttctggatagtggttggtttcgactcattataatgtatgtctaacggcttcaatcgcgcgtt agaaatt gcttttttagtttctatattaataggagatagttgttgcggcatagtaaaaatgaaatgataactgtttaaaaatagct cttag tatgggaattacaatggatgaggaagtgatatttgaaactcctagagaattaatatctattaaacgaataaaagatatt c caagatcaaaagacacgcatgtgthgctgcgtgtataacaagtgacggatatccgttaataggagctagaagaactt cattcgcattccaagcgatattatctcaacaaaattcagattctatctttagagtatccactaaactattacggtttat gtact acaatgaactaagagaaatctttagacggttgagaaaaggttctatcaacgatatcgatcctcactttgaagagttaat attattgggtggtaaactagataaaaaggaatctattaaagattgtttaagaagagaattaaaagaggaaagtgatga acgtataacagtaaaagaatttggaaatgtaattctaaaacttacaacacgggataaattatttaataaagtatatata a gttattgcatggcgtgttttattaatcaatcgttggaggatttatcgcatactagtatttacaatgtagaaattagaaa gatta aatcattaaatgattgtattaacgacgataaatacgaatatctgtcttatatttataatatgctagttaatagtaaatg aactt ttacagatctagtataattagtcagattattaagtataatagacgactagctaagtctattatttgcgaggatgactct caa attattacactcacggcattcgttaaccaatgcctatggtgtcataaacgagtatccgtgtccgctattttattaacta ctgat aacaaaatattagtatgtaacagacgagatagttttctctattctgaaataattagaactagaaacatgtctagaaaga a acgattatttctgaattattccaattatttgtccaaacaggaaagaagtatactatcgtcatttttttctctagatcca gctact

-89-actgataatgatagaatagatgctatttatccgggtggcatacccaaaaggggtgagaatgttccagagtgtttatcca gggaaattaaagaagaagttaatatagacaattcttttgtattcatagacactcggttttttattcatggcatcataga agat accattattaataaattttttgaggtaatcttctttgtcggaagaatatctttaacgagtgatcaaatcattgatacat ttaaaa gtaatcatgaaatcaaggatctaatatttttagatccgaattcaggtaatggactccaatacgaaattgcaaaatatgc t ctagatactgcaaaactcaaatgttatggccatagaggatgttattacgaatcattaaaaaaattaactgaggatgatt g attagaaaatataaattaatttaccatcgtgtatttttataacgggattgtccggcatatcatgtagatagttaccgtc tacat cgtatactcgaccatctacgcctttaaatcctctatttattgacattaatctattagaattggaataccaaatattagt accct caattagtttattggtaatattttttttagacgatagatcgatggctcttgaaaccaaggttttccaaccggactcatt gtcgat cggtgagaagtctttttcattagcatgaatccattctaatgatgtatgtttaaacactctaaacaattggacaaattct tttga tttgctttgaatgatttcaaataggtcttcgtctacagtaggcataccattagataatctagccattataaagtgcacg tttac atatctacgttctggaggagtaagaacgtgactattgagacgaatggctcttcctactatctgacgaagagacgcctcg ttccatgtcatatctaaaatgaagatatcattaattgagaaaaaactaataccctcgcctccactagaagagaatacgc atgttttaatgcattctccgttagtgtttgattcliggttaaactcagccaccgccttgattctagtatcttttgttct agatgaga actctatattagagataccaaagactttgaaatatagtaataagatttctattcctgactgattaacaaatggttcaaa ga ctagacatttaccatgggatgctaatattcccaaacatacatctataaatttgacgcttttctcttttaattcagtaaa tagag agatatcagccgcactagcatcccctttcaatagttctccctttttaaaggtatctaatgcggatttagaaaactctct atct cttaatgaatttttaaaatcattatatagtgttgctatctcttgcgcgtattcgcccggatcacgattttgtctttcag gaaagct atcgaacgtaaacgtagtagccatacgtctcagaattctaaatgatgatatacctgtttttatttcagcgagtttagcc ttttg ataaatttcttcttgctttttcgacatattaacgtatcgcattaatactgttttcttagcgaatgatgcagacccttct acgtcatc aaaaatagaaaactcgttattaactatgtacgaacataggcctcctagtttggagactaattctttctcatcaactaga cg tttattctcaaatagcgattggtgttgtaaggatcctggtcgtagtaagttaaccaacatggtgaattcttgcacacta ttaa cgataggtgtagccgataaacaaatcatcttatggttttttaatgcgatggtcttagataaaaaattatatactgaacg agt aggacggatcttaccatcttctttgattaatgatttagaaatgaagttatgacattcatcaataatgacgcatattcta ctctt ggaattaatagttttgatattagtaaaaaatttatttctaaaattttgatcatcgtaattaataaaaatacaatccttc gttatct ctggagcgtatctgagtatagtgttcatccaaggatcttctatcaaagcclitttcaccaataagataatagcccaatt cgt ataaatatccttaagatglitgagaatatatacagtagtcattgttttaccaacacccgtttcatggaacaataaaaga ga atgcatactgtctaatcctaagaaaactcttgctacaaaatgttgataatccttgaggcgtactacgtctgttcccatc attt caacaggcatattagtagttctgcgcaatgcataatcgatataggccgcgtgtgatttactcatttatgagtgataagt aa taactatgttttaaaaatcacagcagtagtttaactagtcttctctgatgtttgttttcgatactttttgaatcagaag tcatact agaataaagcaacgagtgaacgtaatagagagcttcgtatactctattcgaaaactctaagaacttattaatgaattcc gtatccactggattglitaaaatactaaattgaacactgttcacatccttccaagaagaagacttagtgacggacttaa c atgagacataaataaatccaaatttlitttacaaacatcactagccaccataatggcgctatctttcaaccagctatcg ctt acgcattttagcagtctaacatttttaaagagactacaatatattctcatagtatcgattacacctctaccgaataaag ttg gaagtttaataatacaatatttttcgtttacaaaatcaaataatggtcgaaacacgtcgaaggttaacatcttataatc gct

-90-aatgtatagattgttttcagtgagatgattattagatttaatagcatctcgttcacgtttgaacagtttattgtgtgcg ctgaggt cggcaactacggcgtccgctttagtactcctcccataatactttacgctattaatctttaaaatttcatagactttatc tagat cgctttctggtaacatgatatcatgtgtaaaaagttttaacatgtcggtcggcattctatttagatcattaactctaga aatct gaagaaagtaattagctccgtattccagactaggtaatgggcttttacctaaagacaagttaagttctggcaatglitc at aaaatggaagaaggacatgcgttccctcccggatattttttacaatttcatccatttacaactctatagtttgttttca ttattat tagttattatctcccataatcttggtaatacttaccccttgatcgtaagataccttatacaggtcattacatacaacta ccaat tgtttttgtacataatagattggatggttgacatccatggtggaataaactactcgaacagatagtttatctttccccc tagat acattggccgtaatagttgtcggcctaaagaatatctttggtgtaaagttaaaagttagggttcttgttccattattgc tttttgt cagtagttcattataaattctcgagatgggtccgttctctgaatatagaacatcatttccaaatctaacttctagtcta gaaa taatatcggtcttattcttaaaatctattcccttgatgaagggatcgttaatgaacaaatccttggcctttgattcggc tgatct attatctccgttatagacgttacgttgactagtccaaagacttacaggaatagatgtatcgatgatgttgatactatgt gat atgtgagcaaagattgttctcttagtggcatcactatatgttccagtaatggcggaaaacttlitagaaatgttatata taaa agaattttlicgtgttccaaacattagcagattagtatgaagataaacactcatattatcaggaacattatcaattttt acat acacatcagcatcttgaatagaaacgataccatcttctggaacctcaacaatctcggcagactccggataaccagtc ggtgggccatcactaacaataactagatcatccaacaatctactcacatatgcatctatataatctttttcatcttgtg agta ccctggatacgaaataaatttattatccgtatttccataataaggtttagtataaacagagagcgatgttgccgcatga ac ttcagttacagtcgccgttggttggtttatttgacctattactctcctaggtttctctataaacgatggtttaatttgt acattctta accatatatccaataaagctcaattcaggaacataaacaaattctttgttgaacgtttcaaagtcgaacgaagagtcac gaataacgatatcggatactggattgaaggttaccgttacggtaatttttgaatcggatagtttaagactgctgaatgt atc ttccacatcaaacggagttttaatataaacgtatactgtagatgglictttaatagtgtcattaggagttaggccaata gaa atatcattaagttcactagaatatccagagtglitcaaagcaattgtattattgatacaattattatataattcttcgc cctcaa tttcccaaataacaccgttacacgaagagatagatacgtgattaatacatttatatccaacatatggtacgtaaccgaa t cttcccatacctttaacttctggaagttccaaactcagaaccaaatgattaagcgcagtaatatactgatccctaattt cg aagctagcgatagcctgattgtctggaccatcgtttgtcataactccggatagagaaatatattgcggcatatacaaag t tggaatttgactatcgactgcgaagacattagaccgtttaatagagtcatccccaccgatcaaagaattaatgatagta t tattcattlictatttaaaatggaaaaagcttacaataaactccgtagagaaatatctataatttgtgagtlitcctta aagta acagcttccgtaaacgccgtctttatctcttagtaggtttattgtatttatgaccttttccttatcttcatagaatact aaaggca acaaagaaatttttggttcttctctaagagctacgtgagacttaaccatagaagccaacgaatccctacatattttaga a cagaaatacccaacttcaccacccttgaatgtctcaatactaataggtctaaaaaccaaatcttgattacaaaaccaa cacttatcaattacactatttgtcttaatagacacatctgccatagatttataatactttggtagtatacaagcgagtg clictt ctttagcgggcttaaagactgctttaggtgctgaaataaccacatctggaaggcttactcgcttagccatttaattacg ga actatttttttatacttctaatgagcaagtagaaaacctctcatctacaaaaacatactcgtgtccataatcctctacc atag ttacacgttttttagatctcatatgtgctaaaaagttttcccatactaattggttactattatttttcgtataattttt aacagtttga ggttttagatlittagttacagaagtgatatcgaatattttatccaaaaagaatgaataattaattgtcttagaaggag tgtttt

-91-cttggcaaaagaataccaagtgcttaaatatttctactacttcattaatclittctgtactcagattcagtttctcatc ttttactt gattgattatttcaaagactaacttataatcctttttatttattctctcgttagccttaagaaaactagatacaaaatt tgcatct acatcatccgtggatatttgattthttccatgatatccaagagttccgagataatttctccagaacattgatgagacaa taa tctccgcaatacatttctcaaatgaataagtttattagacacatggaagtttgactttttttgtacctttgtacatttt tgaaatac agactcgcaaaaaatacaatattcatatccttgttcagatactataccgttgtgtctacaaccgctacataatcgtaga ttc atgttaacactctacgtatctcgtcgtccaatattttatataaaaacattttatttctagacgttgccagaaaatcctg taatat ttttagttttttgggctgtgaataaagtatcgccctaatatggttaccgtcctccgccaatatagtagttaaattatcc gcaca tgcagaagaacaccgcttaggcggattcagtacaatgttatatttttcgtaccaactcatttaaatatcataatctaaa ata gttctgtaatatgtctagcgctaatatattgatcataatcctgtgcataaattaagatacaacaatgtctcgaaatcat cga catggcttcttccatagttagaagatcgtcgtcaaagttagcaacgtgattcatcaacatttgctgttttgaggcagca aat actgaaccgtcgccattcaaccattcataaaaaccatcgtctgaatccattgataatttcttgtactggtttttgagag ctcg catcaatctagcatttctagctcccggattgaaaacagaaagaggatcgtacatccagggtccattttctgtaaataga atcgtataatgtcccttcaagaagatatcagacgatccacaatcaaagaattggtctccgagtttgtaacaaactgcgg actttaacctatacatgataccgtttagcatgatttctggtgatacgtcaatcggagtatcatctattagagatctaaa gcc ggtgtaacattctccaccaaacatattcttattctgacgtcgttctacataaaacatcattgctccattaacgataaca ggg gaatgaacagcactacccatcacattagttcccaatggatcaatgtgtgtaactccagaacatcttccatatcctatgt ta ggaggagcgaacaccactcttccactattgccatcgaatgccatagaataaatatccttggaattgatagaaatcgga ctgtcggatgligtgatcatcttcataggattaacaactatgtatggtgccgcctgaagtttcatatcgtaactgatgc cgttt ataggtctagccacagaaaccaacgtaggtctaaatccaactatagacaaaatagaagccaatatctgttcttcatct gtcataacttgagagcatccagtatgaataatcttcattagatggggatctaccgcatcatcatcgttacaataaaaaa tt cccattctaatgttcataattgcttttctaatcatggtatgcatgtttgctctctgaatctctgtggaaattagatctg atacacc tgtaatcactatcggattatcctccgtaagacgattaaccaacaacatataattataagactttacttttctaaattca taaa gttgctggattaggctataggtgtctccatgtacatacgcgttctcgagcgcaggaagtttaataccgaatagtgccat c agaataggatgaatatagtaattagtttctggttttctataaataaaagacaaatcligtgaactagacatatcggtaa aa tgcatggattggaatcgtgtagtcgacagaagaatatgatgattagatggagagtatattttatctaactctttgagtt ggt caccgattctaggactagctcgagaatgaataagtactaaaggatgagtacatttcacagaaacactagcattgttca atgtgctctttacatgggtaaggagttgaaatagctcgtttctatttglictgacaatatttagtttattcataatgtt aagcatat cctgaatagtaaagttagatgtgtcatacttgttagtagttagatatttagcaattgcattcccatcatttctcaatct cgtact ccaatcatgcgtggatgctacttcgtcgatggaaaccatacaatccttlitgataggctgttgagattgattatttcct gcac gtttaggtttggtacgttgatttctagcccctgcggatataaagtcatcgtctacaattttggataatgaattgcatac actac aagacaaagatttatcagaagtgtgaatatgatcttcatctaccaaagaaagagtttgattagtataactagattttag tc ctgcgttagatgttaaaaaaacatcgctattgaccacggcttccattatttatattcgtaglitttactcgaaagcgtg atttta atattcaatcttattacttttggaatcgttcaaaacctttgactaattgtagaatttgatctattgccctacgcgtata ctccctt gcatcatatacgttcgtcaccagatcgtttgtttcggcctgaagttggtgcatatctctttcaacattcgacatgagat cctta

-92-agggccatatcgtctagattttgttgagatgctgctcctggatttggattttgttgtgctgttgtacatactgtaccac cagtag gtgtaggagtacatacagtggccacaataggaggttgaggaggtgtaaccgttggagtagtacaagaaatacttcca tccgattgttgtgtacatgtagttgliggtaacgtctgagaaggttgggtagatggcggcgtcgtcgtcttttgatctt tattaa atttagagataatatcctgaacagcattgctcggcgtcaacgctggaaggagtgaactcgccggcgcatcagtatctg cagacagccaatcaaaaagattagacatatcagatgatgtattagtttgttgtcgtgglittggtgtaggagccggtgt ag ctgttggaaccggctgtggagttatatgaatagttggttgtagcggttggataggctgtctgctggcggccatcatatt atc tctagctagttgttctcgcaactgtctttgataatacgactcttgagactttagtcctatttcaatcgcttcatccttt ttcgtatcc ggatccttttcttcagaataatagattgacgactttggtgtagaggattctgccagcccctgtgagaacttgttaaaga agt ccatttaaggctttaaaattgaattgcgattataagattaaatggcagacacagacgatattatcgactatgaatccga t gatctcaccgaatacgaggatgatgaagaagaggaagaagatggagagtcactagaaactagtgatatagatccc aaatcttcttataagattgtagaatcagcatccactcatatagaagatgcgcattccaatcttaaacatatagggaatc at atatctgctcttaaacgacgctatactagacgtataagtctatttgaaatagcgggtataatagcagaaagctataact t gcttcaacgaggaagattacctctagtttcagaattttctgacgaaacgatgaagcaaaatatgctacatgtaattata c aagagatagaggagggttcttgtcctatagtcatcgaaaagaacggagaattgligtcggtaaacgattttgacaaag atggtctaaaattccatctagactatattatcaaaatttggaaacttcaaaaacgatattagaatttatacgaatatcg ttct ctaaatgtcacaatcaagtctcgcatgttcagcaatttattgtcgtactttatatcgtgttcattaacgatatcttgca aaata gtaatgattctatcttccttcgatagatattclicagagattattgtcttatattctttcttgttatcagatatgaatt tgataagact ttgaacattattgatacccgtctgtttaatlitttctacagatattttagttttggcagattctatcgtatctgtcaat agacatcca acatcgacattcgacgtcaattgtctataaatcaacgtataaattttagaaataacattagcgaattgttgtgcattga tgt cgttattctgaaacagtatgattttaggtagcattttcttaacaaagagaacgtatttattgttactcagttgaacaga tgata tatccagattactaacgcatctgattccatataccaaactttcagaagaaatggtgtacaattgthgtattcattcaat gtct ctttttcagaaattagtttagagtcgaatactgcaataattttcaagagatagttttcatcagataagattttatttag tgtaga tatgataaaactattgttttgttggagaacttgatacgccgcgttctctgtagtcgacgctctcaaatgggaaacaatc tcc attatttttttggaatcggatacaatatcttcggtatcttgacgcaatctagtatacatagagttaagagaaattagag tttgt acattaagcaacatgtctctaaatgtggctgcaaacttttccttttccacatcatctagtttattatataccgatttca caacg gcaccagatttaaggaaccagaatgaaaaactctgataactacaatatttcatcatagttacgattttatcatcttcta tag ttggtgtaatagcgcatacctttttctccaagactggaaccaacgtcataaaaatgtttaaatcaaaatccatatcaac at ctgatgcgctaagaccagtctcgcgttcaagattatctttactaatggtgacgaactcatcgtatagaactctaagttt gtc cattatttatttacagatttagttgtttaatttatttgtgctcttccagagttgggatagtatttttctaacgtcggta ttatattattag gatctacgttcatatgtatcataatattaatcatccacgttttgataaatctatctttagcttctgaaataacgtattt aaacaa aggagaaaaatatttagctacggcatcagacgcaataacattttttgtaaatgtaacgtatttagacgacagatcttcg tt aaaaagttttccatctatgtagaatccatcggttgttaacaccattcccgcgtcagattgaataggagtttgaatagtt tgttt tggaaatagatccttcaataacttatagttgggtgggaaaaaatcgattttatcactagactctttcttttttactatc attacct catgaactatttcttgaatgagtatatgtattttctttcctatatcggacgcgttcattggaaaatataccatgtcgtt aactata

-93-agaatatttttatcctcgtttacaaactgaataatatcagatgtagttcgtaaacgaactatatcatcaccagcacaac at ctaactatatgatatccactagtttcctttagtcgtttattatcttgttccatattagcagtcattccatcatttaaga aggcgtc aaagataatagggagaaatgacattttggattctgttacaactttaccaaaattaaggatatacggacttactatcttt ttct caacgtcgatttgatgaacacacgatgaaaatgtacttcgatgagattgatcatgtagaaaacaacaagggatacaa tatttccacatatcatgaaatatattaagaaatcccaccttattatatttccccaaaggatccatgcatgtaaacatta tgcc gttatcattaataaagacttctttctcatcggatctgtaaaagttgttactgatttttttcattccaggatctagataa ttaataat gatgggttttctattcttattctttgtattttggcatatcctagaccagtaaacagtttccactttggtaaaatcagca gacttttg aacgctattaaacatggcattaatggcaataactaaaaatgtaaaatatttttctatgttaggaatatgglitttcact ttaat agatatatggtttttggccaaaatgatagatatlittttatccgaggatagtaaaatattattagtcgccgtctctata aaaat gaagctagtctcgatatccaattttattctagaattgataggagtcgccaaatgtaccttatacgttatatctcccttg atgc gttccatttgtgtatctatatcggacacaagatctgtaaatagttttacgttattaatcatcacggtatcgccgtcgct agata acgctaatgtaccatccaagtcccaaatggagagatttaactgttcatcgtttagaataaaatgattaccggtcatatt aa taaagtgttcatcgtatctagataacaacgacttataattaatgtccaagtcttgaactcgctgaatgatcttttttaa ccca gttagttttagattggtacgaaatatattgttaaactttgattctacagtaatgtccaaatctagttgtggaaatactt ccatca acattgtttcaaacttgataatattattatctacatcttcatacgatccaaattccggaatagatgtatcgcacgctct ggcc acccagataaccaaaaagtcacacgctccaggatatacattgtataaaaagctatcgttttttagtagtgtttttttct gagt atatacgaagggattaaaaatagtattatcaacgtaactatattccaaattattcttatgagaatagataataatatcg tcc ttaatatctaacaaatttcctaaatatccctttaattgagtcattcgaagcgtcaatagaatatgtctcttaactattt ccggct gttgtatatttaaatgacttcgtaaaaaataatatatgggcgacttctcatctatgtaatcatatggagtgagatatag ggct cgttctacctcctgccccttacccacctgtaataccaattgcggacttactatatatcgcatatttatatcgtggggta aagt gaaaatctactaccgatgatgtaagtcttacaatgttcgaaccagtaccagatcttaatttggaggcctccgtagaact a ggggaggtaaatatagatcaaacaacacctatgataaaggaaaatagcggttttatatcccgtagtagacgtctattc gcccatagatctaaggatgatgagagaaaactagcactacgattctttttacaaagactttattttttagatcatagag ag attcattatttgttcagatgcgttgacgctgtaaaagacgtcactattaccaaaaaaaataacattatcgtggcgcctt ata tagcacttttaactatcgcatcaaaaggatgcaaacttacagaaacaatgattgaagcattctttccagaactatataa t gaacatagtaagaaatttaaattcaactctcaagtatccatcatccaagaaaaactcggataccagtttggaaactatc acgtttatgattttgaaccgtattactctacagtagctctggctattcgagatgaacattcatctggcatttttaatat ccgtca agagagttatctggtaagttcattatctgaaataacatatagattttatctaattaatctaaaatctgatcttgttcaa tggagt gctagtacgggcgctgtaattaatcaaatggtaaatactgtattgattacagtgtatgaaaagttacaactggtcatag a aaatgattcacaatttacatgttcattggctgtggaatcaaaacttccaataaaattacttaaagatagaaatgaatta ttt acaaaattcatcaacgagttaaaaaagaccagttcattcaagataagcaaacgcgataaggatacgctactaaaat attttacttaggactggagttagaatttatagacgactcatttcgtttatcattattagtattcttcttgttatcttgt tcagaaatat acagcaatgctatgcctaatactaaatacattatcatgcttgcaatggctctaacaacgacgaaccaaaatgaatttgg tcgtagctlitgttcacaaaaatacataaagaaatgtctacataaatctatggcgccattggctacttgaaatagcgcc a

-94-gtcctcctacagattttaatatagctgtataacatgacatttattcatcatcaaaagagacagagtcaccatctgtcat attt agattttttlicatgtgttcaaagtatcctctactcatttcattataatagtttatcatacttagaattttaggacgga tcaatgag taagacttgactagatcgtcagtagtaatttgtgcatcgtctattctgcatccgcttcgtcgaataatgtatagcatcg ctttg agattctccatagctatcaagtctttatacaatgacatggaaatatctgtgaatactttatacttctccaacatcgatg cctt aacatcatcgcctactttagcattgaaaatacgttctattgtgtagatggatgtagcaagatttttaaacaacaatgcc attt tacacgatgattgcctcaagtctccaatcgtttgtttagaacgattagctacagagtccaatgcttggctgactagcat att attatctttagaaattgtattcttcaatgaggcgtttatcatatctgtgatttcgttagtcatattacagtctgactgg gttgtaat gttatccaacatatcacctatggatacggtacacgtaccagcatttgtaataatcctatctaagatgttgtatggcatt gcg cagaaaatatclictcctgtaatatttccactctcgataaatctactcagattattcttaaatgccttattctctggag aaaag atatcagtgtccatcatttcattaatagtatacgcagaaaagataccacgagtatcaattctatccaagatacttatcg gtt ccgagtcacagataatggtttcctctccttcgggagatcctgcatagaaatatctaggacaatagtttctatactgtct gta actctgataatctctaaagtcactaactgataccatgaaattgagaagatcaaacgctgaagtaattaatttttctgcc tc gtttttactacaactagttttcatcaatgtagtgacgatgtattgtttagttactcttggtctaatactgatgatagag atattatt acttcccataatggatcttctagtagtcaccttaaagcccattgatgcaaatagcagatagataaagtcttggtatgac tc ctttctaatatagtacggactacctttgtcacccaactttatacccacataagccataacaacctctttaatagccgtt tcat gaggtttatcagccatgagcctgagtagttggaagaatctcatgaatcctgtctcagaaagtcctatatgcatgataga tt tatctttcctgggaaactctcgtatagtcatagatgaaatactcttcaaagtttctgaaataagattagtaacagtctt acct ccgactactctaggtaacaaacaaactctaataggtgttttctctgcggagataatatcagaaaggatagagcaataa gtagtattattgtgattataaagaccgaatacataacaggtagaatttataaacatcatgtcctgaaggtttttagact tgta ttcctcgtaatccataccgtcccaaaacatggatttggtaactttgatagccgtagatctttgttccttcgccaacagg ttaa agaaattaataaagaatttgtggtttctacctatgtctacaaattgcacgtttggaagcgccacggttacattcactgc ag cattttgaggatcgcgagtatgaagtacgatgttattgtttactggtatatctggaaagaattctaccagtctaggaat aag agattgatatcgcatagaaatacaaaagttcataatctcatcatctaagagcattttgttaccattgtaataaatatcc act ctgtcatatgtataaatgaagtactgttcaaacatgatgagatgtttatatgttggcatagtagtgagatctacgtttg gtaa tggcaatgtattaagattaactccataatgtctagcagcatctgcgatgttataagcgttgtcaaagcggggtcgatct tgt gctgttatatattgtctaacacctataagattatcaaaatcttgtctgcttaatacaccgttaacaatttttgccttga attctttt attggtgcattaataacatccttatagaggatgttaaacaaataagtgttatcaaagttaagatctggatatttctttt ctgct agaacatccattgagtcggagccatctggtttaatataaccaccgataaatctagctctgtattctgtatccgtcaatc taa tattaagaaggtgttgagtgaaaggtggaagatcgtaaaagctgtgagtattaatgataggattagtttccgaactaat g ttaattggggtattaataatatctatatttccagcgttaagtgtaacattaaacagttttaattcacgtgacgtggtat caatta aataattaatgcccaatttggatatagcagcctgaagctcatcttgtttagttacggatcctaatgagttattaagcaa tat atcgaacggatgaacgaaggttgttttaagttggtcacatactttgtaatctagacatagatgcggaagaacggtagaa actatacgaaataaatattcagagtcctctaattgatcaagagtaactattgacttaataggcatcatttatttagtat taaa tgacgaccgtaccagtgacggatatacaaaacgatttaattacagaglittcagaagataattatccatctaacaaaaa

-95-ttatgaaataactcttcgtcaaatgtctattctaactcacgttaacaacgtggtagatagagaacataatgccgccgta gt gtcatctccagaggaaatatcctcacaacttaatgaagatctatttccagatgatgattctccggccactattatcgaa cg agtacaacctcatactactattattgacgatactccacctcctacgtttcgtagagagttattgatatcggaacaacgt ca acaacgagaaaaaagatttaatattacagtatcgaaaaatgctgaagcaataatggaatctagatctatgatatcttct atgccaacacaaacaccatccttgggagtagtttatgataaagataaaagaattcagatgttggaggatgaagtggtt aatcttagaaatcaacgatctaatacaaaatcatctgataatttagataattttaccagaatactatttggtaagactc cgt ataaatcaacagaagttaataagcgtatagccatcgttaattatgcaaatttgaacgggtctcccttatcagtcgagga c ttggatgtttgttcagaggatgaaatagatagaatctataaaacgattaaacaatatcacgaaagtagaaaacgaaa aattatcgtcactaacgtgattattattgtcataaatattatcgagcaagcattgctaaaactcggatttgaagaaatc aa aggactgagtaccgatatcacttcagaaattatcgatgtggagatcggagatgactgcgatgctgtagcatcaaaact aggaatcggtaacagtccggttcttaatattgtattgtttatactcaagatattcgttaaacgaattaaaattatttaa tttaat acattcccatatccagacaacaatcgtctggattaatctgttcctgtcgtctcataccggacgacatattaatcttttt attag taggcatctttttagatgglitctttttcccagcattaactgagtcgatacctagaagatcgtgattgatctctccgac cattcc acgaacttctaattggccgtctctgacggtaccataaactattttaccagcattagtaacagcttggacaatctgacca tc catcgcattgtacgatgtagtagtaactgttgttctacgtctaggagcaccagaagtatttttggagcccttggatgtt gatg tagaagaagacgaggattttgattttggtttacatgtaatacattttgtatcacatgcgccggcagtcacatctgtttg aga attaagattattgttgcctcctttgacggctgcatctccaccgatttgcgctagtagatttttaagctgtggtgtaatc ttattaa ctgtttcgatataatcatcgtaactgcttctaacggctaaattttttttatccgccatttagaagctaaaaatattttt atttatgc agaagatttaactagattatacaatgaactaatatgatccttttccagattatttacaaacttggtattttttggttct ggagga ggcgaatttaaattcggacttggatttggattttgtgggttcttgatcttattatacagcgcatataggatggcgacgg taac tgctacgcaaataccgatcaacaaaagaataccaatcatttattgacaataacttcactattgatcaagtatgcaatat a tcatcttttcactaaataagtagtaataatgattcaacaatgtcgagatatatggacgataataatttagttcatggaa atat cgctatgattggtatgaatgactccgctaactctgtggggcgcgcagtgctttccccacatagaataaattagcattcc g actgtgataataataccaagtataaacgccataatactcaatactttccatgtacgagtgggactggtagacttactaa a gtcaataaaggcgaagatacacgaaagaatcaaaagaatgattccagcgattagcacgccggaaaaataatttcc aatcataagcatcatatccatttaactaataaaaattttaaatcgccgaatgaacaaagtggaatataaaccatataaa aacaatagtttgtactgcaaaaataatatctatttttgttttcgaagatatggtaaaattaaatagtagtacacagcat gtta taactaacagcagcaacggctcgtaattacttatcatttactagacgaaaaggtggtgggatattttcttgctcaaata at acgaatatatcacccatccattttatgcgatgtttatatactctaatctttaatagatctatagacgacgggtttacca acaa tatagattttatcgattcatctaatttaaacccttccttaaacgtgaatgatctattatctggcataacgatgactcta cccga tgaatcggacaatgtactgggccatgtagaataaattatcaacgaattatcgtctacgaacatttatatcatttgtttt aattt tagtacgcgaataaatagatataaaatagaaaataacagatattacaaccaatgttatggccgcgcccggccggcc gcggccgctttttlictagacactaaataaatagtaagattaaattaattataaaattatgtatataatattaattata aaatt

-96-atgtatatgatttactaactttagttagataaattaataatacataaattttagtatattaatattataaattaataat acataaa ttttagtatattaatattatattttaaatatttatttagtgtctagaaaaaaaggcctagcaggcc [0074] Sequence of sMVA fragment 3 (F3, 62068 bp in length) (SEQ ID NO:
14):
ggcctagcaggcctttttttctagacactaaataaatagtaagattaaattaattataaaattatgtatataatattaa ttata aaattatgtatatgatttactaactttagttagataaattaataatacataaattttagtatattaatattataaatta ataatac ataaattttagtatattaatattatattttaaatatttatttagtgtctagaaaaaaaggccggccgggtattaataat atctat atttccagcgttaagtgtaacattaaacagttttaattcacgtgacgtggtatcaattaaataattaatgcccaatttg gata tagcagcctgaagctcatcttgtttagttacggatcctaatgagttattaagcaatatatcgaacggatgaacgaaggt t gttttaagttggtcacatactttgtaatctagacatagatgcggaagaacggtagaaactatacgaaataaatattcag a gtcctctaattgatcaagagtaactattgacttaataggcatcatttatttagtattaaatgacgaccgtaccagtgac gga tatacaaaacgatttaattacagagttttcagaagataattatccatctaacaaaaattatgaaataactcttcgtcaa at gtctattctaactcacgttaacaacgtggtagatagagaacataatgccgccgtagtgtcatctccagaggaaatatcc tcacaacttaatgaagatctatttccagatgatgattctccggccactattatcgaacgagtacaacctcatactacta tta ttgacgatactccacctcctacgtttcgtagagagttattgatatcggaacaacgtcaacaacgagaaaaaagatttaa tattacagtatcgaaaaatgctgaagcaataatggaatctagatctatgatatcttctatgccaacacaaacaccatcc t tgggagtagtttatgataaagataaaagaattcagatgttggaggatgaagtggttaatcttagaaatcaacgatctaa t acaaaatcatctgataatttagataattttaccagaatactatttggtaagactccgtataaatcaacagaagttaata ag cgtatagccatcgttaattatgcaaatttgaacgggtctcccttatcagtcgaggacttggatgtttgttcagaggatg aaa tagatagaatctataaaacgattaaacaatatcacgaaagtagaaaacgaaaaattatcgtcactaacgtgattattat tgtcataaatattatcgagcaagcattgctaaaactcggatttgaagaaatcaaaggactgagtaccgatatcacttca gaaattatcgatgtggagatcggagatgactgcgatgctgtagcatcaaaactaggaatcggtaacagtccggttctt aatattgtattgtttatactcaagatattcgttaaacgaattaaaattatttaatttaatacattcccatatccagaca acaat cgtctggattaatctgttcctgtcgtctcataccggacgacatattaatctttttattagtaggcatctttttagatgg tttctttttc ccagcattaactgagtcgatacctagaagatcgtgattgatctctccgaccattccacgaacttctaattggccgtctc tg acggtaccataaactattttaccagcattagtaacagcttggacaatctgaccatccatcgcattgtacgatgtagtag t aactgttgttctacgtctaggagcaccagaagtatttttggagcccttggatgttgatgtagaagaagacgaggatttt ga ttttggtttacatgtaatacattttgtatcacatgcgccggcagtcacatctgtttgagaattaagattattgttgcct cctttga cggctgcatctccaccgatttgcgctagtagatttttaagctgtggtgtaatcttattaactgtttcgatataatcatc gtaact gcttctaacggctaaattthtttatccgccatttagaagctaaaaatatttttatttatgcagaagatttaactagatt ataca atgaactaatatgatccttttccagattatttacaaacttggtattlittggttctggaggaggcgaatttaaattcgg acttgg atttggattttgtgggttcttgatcttattatacagcgcatataggatggcgacggtaactgctacgcaaataccgatc aac aaaagaataccaatcatttattgacaataacttcactattgatcaagtatgcaatatatcatcttttcactaaataagt agt

-97-aataatgattcaacaatgtcgagatatatggacgataataatttagttcatggaaatatcgctatgattggtatgaatg ac tccgctaactctgtggggcgcgcagtgctttccccacatagaataaattagcattccgactgtgataataataccaagt a taaacgccataatactcaatactttccatgtacgagtgggactggtagacttactaaagtcaataaaggcgaagatac acgaaagaatcaaaagaatgattccagcgattagcacgccggaaaaataatttccaatcataagcatcatatccattt aactaataaaaattttaaatcgccgaatgaacaaagtggaatataaaccatataaaaacaatagtttgtactgcaaaa ataatatctatttttgttttcgaagatatggtaaaattaaatagtagtacacagcatgttataactaacagcagcaacg gct cgtaattacttatcatttactagacgaaaaggtggtgggatattttcttgctcaaataatacgaatatatcacccatcc atttt atgcgatgtttatatactctaatctttaatagatctatagacgacggglitaccaacaatatagattttatcgattcat ctaatt taaacccttccttaaacgtgaatgatctattatctggcataacgatgactctacccgatgaatcggacaatgtactggg c catgtagaataaattatcaacgaattatcgtctacgaacatttatatcatttgttttaattttagtacgcgaataaata gatat aaaatagaaaataacagatattacaaccaatgttatggccgcgcccaaccaggtaggcagttttattttatcttttact ac aggttctcctggatgtacgtcaccaacggcggacgtagttctagtacaattagacgtaagttccgcttgggaatttttt aa cgctaaagagttaacgttaatcgtgcacccaacgtatttacatctagttctttgaacatcttgattataatataaccat tttct atctctagattcgtcggtgcactcatgtaaccaacataccctaggtcctaaatatttatctccggaattagattttgga taat tcgcgcaccaacaatttctatttcctttatgatcgttacaaaagacgtataatgccgtatccccaaaagtaaaataatc ag gacgaataattctaataaactcagaacaatatctcgcatccatatgtttggagcaaatatcggaataagtagacatagc cggtttccgttttgcacgtaaccattctaaacaattggggtttccaggatcgtttctacaaaatccagtcatgaaatca tca caatgttctgtcttgtaattattattaaatatttttggacagtgtttggtatttgtcttagaacaacattttgccacgc tatcactat cgcccaggagataatccttttttataaaatgacatcgttgcccggatgctatataatcagtagcgtgttttaaatcctt aata tattcaggagttacctcgttctgataatagattaatgatccaggacgaaatttgaaagaactacatggttctccatgaa tt aatacatattgtttagcaaattcaggaactataaaactactacaatgatctatcgacataccatctatcaaacaaaact t gggtttaatttctcccggagatgtttcataatagtacgtataactttcttctgcaaacttaacagctctattatattca ggataa ttaaaacctaattccatatatttgtctcgtatatctgctattcctggtgctattttgattctattaagagtaacggctg cccccatt tttaataatcgtcagtatttaaactgttaaatgttggtatatcaacatttaccttatttcccgcagtataaggtttgtt gcaggta tactgttcaggaatggttacatttatactttttctatagtcctgtctttcgatgttcatcacatatgcaaagaacagaa taaac aaaataatgtaagaaataatattaaatatctgtgaattcgtaaatacattgattgccataataattacagcagctacaa ta catacaatagacattcccacagtgttgccattacctccacgatacatttgagttactaagcaataggtaataactaagc t agtaagaggcaatagaaaagatgagataaatatcatcaatatagagattagaggagggctatatagagccaagac gaacaaaatcaaaccgagtaacgttctaacatcattatttttgaagattcccaaataatcattcattcctccataatcg tttt gcatcatacctccatctttaggcataaacgattgctgctgttcctctgtaaataaatctttatcaagcactccagcacc cgc agagaagtcgtcaagcatattgtaatatcttaaataactcatttatatattaaaaaatgtcactattaaagatggagta ta atctttatgccgaactaaaaaaaatgacttgtggtcaacccctaagtctttttaacgaagacggggatttcgtagaagt tg aaccgggatcatcctttaagtttctgatacctaagggattttacgcctctccttccgtaaagacgagtctagtatttga aac attaacaacgaccgataataaaattactagtatcaatccaacaaatgcgccaaagttatatcctcttcaacgcaaagtc

-98-gtatctgaagtagtttctaatatgaggaaaatgatcgaatcaaaacgtcctctatacatcactcttcacttggcgtgtg gat ttggtaagactattaccacgtgttatcttatggctacacacggtagaaaaaccgtcatttgcgtacccaataaaatgtt aa tacatcaatggaagacacaggtagaggcagtcggattggaacataagatatccatagatggagtaagtagtctatta aaggaactaaagactcaaagtccggatgtattaatagtagtcagtagacatctgacaaacgatgcctlitgtaaatata tcaataagcattatgatttgttcatcttggatgaatcacatacgtataatctgatgaacaatacagcagttacaagatt ttta gcgtattatcctccgatgatgtgttattttttaactgctacacctagaccatctaacagaatttattgtaacagtatta ttaatat tgccaagttatccgatctaaaaaaaactatctatgcagtagatagtlittttgagccatattccacagataatattaga cat atgataaaacgattagatggaccatctaataaatatcatatatataccgagaagttattatctgtagacgagcctagaa atcaacttattcttaataccctggtagaagaattcaagtcaggaactattaatcgcattttagttattactaaactacg tgaa catatggtattcttctacaaacgattattagattlittcggatcagaggligtatttataggagacgcccaaaatagac gta ctccagatatggtcaaatcaatcaaggaactaaatagatttatattcgtatccaccttattttattccggtactggttt agata ttcctagtttggattctttgttcatttgctcggcagtaatcaacaatatgcaaatagagcaattactagggagggtatg tcg agaaacagaactattagataggacggtatatgtatttcctagcacatccatcaaagaaataaagtacatgataggaa atttcgttcaacgaattattagtctgtctgtagataaactaggatttaaacaaaaaagttatcggaaacatcaagaatc c gatcccacttctgtatgtacaacatcctccagagaagaacgtgtattaaatagaatatttaactcgcaaaatcgttaag a agtttaagcgacgatccgcatgctgcgcaggccagtgtattacccctcatagtattaatataatccaatgatacttttg tg atgtcggaaatcttaaccaatttagactgacaggcagaacacgtcatgcaatcatcatcgtcatcgataactgtagtct t gggcttctlittgcggctcttcattccggaacgcacattggtgctatccatttaggtagtaaaaaataagtcagaatat gcc ctatagcacgatcgtgcaaaacctggtatatcgtctctatctttatcacaatatagtgtatcgacatclitattattat tgacct cgtttatcttggaacatggaatgggaacatttttgttatcaacggccacctttgccttaattccagatgttgtaaaatt ataac taaacagtctatcatcgacacaaatgaaattcttgtttagacgtttgtagtttacgtatgcggctcgttcgcgtctcat tlittc agatattgcaggtactataatattaaaaataagaatgaaataacataggattaaaaataaagttatcatgacttctagc gctgatttaactaacttaaaagaattacttagtctgtacaaaagtttgaaattttcagattctgcggctatagaaaagt ata attctttggtagaatggggaacatctacttactggaaaataggcgtgcaaaaggtagctaatgtcgagacgtcaatatc tgattattatgatgaggtaaaaaataaaccgtttaatattgatccgggctattacattttcttaccggtatattttggg agcgt ctttatttattcgaagggtaaaaatatggtagaacttggatctggaaactcttttcaaataccagatgatatgcgaagt gc gtgtaacaaagtattagacagcgataacggaatagactttctgagatttgttttgttaaacaatagatggataatggaa g atgctatatcaaaatatcagtctccagttaatatatttaaactagctagtgagtacggattaaacatacccaaatattt ag aaattgaaatagaggaagacacattatttgacgacgagttatactctattatagaacgctctttcgatgataaatttcc aa aaatatccatatcgtatattaagttgggagaacttaggcggcaagttgtagactttttcaaattctcattcatgtatat tgagt ccatcaaggtagatcgtataggagataatatttttattcctagcgttataacaaaatcaggaaaaaagatattagtaaa a gatgtagaccatttaatacgatccaaggttagagaacatacatttgtaaaagtaaaaaagaaaaacacattttccattt t atacgactatgatggaaacggaacagaaactagaggagaagtaataaaacgaattatagacactataggacgag actattatgttaacggaaagtatttctctaaggttggtagtgcaggcttaaagcaattgactaataaattagatattaa tga

-99-gtgcgcaactgtcgatgagttagttgatgagattaataaatccggaactgtaaaacgaaaaataaaaaaccaatcag catttgatttaagcagagaatgtttgggatatccagaagcggattttataacgttagttaataacatgcggttcaaaat ag aaaattgtaaggttgtaaatttcaatattgaaaatactaattgtttaaataacccgagtattgagactatatatggaaa cttt aaccagttcgtctcaatctttaatatcgtcaccgatgtcaaaaaaagattattcgagtgaaataatatgcgcctttgat ata ggtgcaaaaaatcctgccagaactgttttagaagtcaaggataactccgttagggtattggatatatcaaaattagact ggagttctgattgggaaaggcacatagctaaagatttgtcacaatatgaatacactacagttcttctagaacgtcagcc t agaaggtcgccgtacgtcaaatttatctattttattaaaggctttttatatcatacatcggctgccaaagttatttgcg tctcg cctgtcatgtctggtaattcatatagagatcgaaaaaagagatcggtcgaagcatttcttgattggatggacacattcg g attgcgagactccgttccggatagacgcaaattagacgatgtagcggatagtttcaatttggctatgagatacgtatta g ataaatggaatactaattatacaccttataataggtgtaaatctagaaattacataaaaaaaatgtaataacgttagta a cgccattatggataatctatttacctttctacatgaaatagaagatag atatg ccag aactatttttaactttcatctaataag ttgcgatgaaataggagatatatatggtcttatgaaagaacgcatttcctcagaggatatgtttgataatatagtgtat aat aaagatatacatcatgccattaagaaactagtgtattgcgacatccaacttactaaacacattattaatcagaatacgt a tccggtatttaacgattcttcacaagtgaaatgttgtcattatttcgatataaactcagataatagcaatattagctct cgtac agtagagatatttgagagggaaaagtcatctcttgtatcatatattaaaactaccaataagaagagaaaggtcaattat ggggaaataaagaaaactgtacatggaggcactaatgcaaattacttttccggtaaaaagtctgatgagtatctgagc actacagtcaggtccaacattaatcaaccttggatcaaaaccatttctaagagaatgagagtagatatcattaatcact ctatagtaacgcgtggaaaaagctctatattacaaactatagaaattatttttactaatagaacatgtgtgaaaatatt ca aggattctactatgcacattattctatccaaggacaaggatgaaaaggggtgtatacacatgattgacaaattattcta t gtctattataatttatttctgttgttcgaggatatcatccaaaacgagtactttaaagaagtagctaatgttgtaaacc acgt actcacggctacggcattagatgagaaattattcctaattaagaaaatggctgaacacgatgtttatggagttagcaat t tcaaaatagggatgtttaacctgacatttattaagtcgttggatcataccgttttcccctctctgttagatgaggatag caaa ataaagtlitttaaggggaaaaagctcaatattgtagcattacgatctctggaggattgtataaattacgtgactaaat cc gagaatatgatagaaatgatgaaggaaagatcgactattttaaatagcatagatatagaaacggaatcggtagatcg tctaaaagaattgcttctaaaatgaaaaaaaaacactaattcagaaatggatcaacgactcggatataagtttttggtg cctgatcctaaagccggagttttttatagaccgttacatttccaatatgtatcgtattctaattttatattgcatcgat tgcatga aatcttgaccgtcaagcggccactcttatcgtttaagaataatacagaacgaattatgatagaaattagcaatgttaaa gtgactcctccagattactcacctataatcgcgagtattaaaggtaagagttatgacgcattagccacgttcactgtaa a tatctttaaagaggtaatgaccaaagagggtatatccatcactaaaataagtagttatgagggaaaagattctcatttg a taaaaattccgctactaataggatacgggaataaaaatccacttgatacagccaagtatcttgttcctaatgtcatagg t ggagtctttatcaataaacaatctgtcgaaaaagtaggaattaatctagtagaaaagattacaacatggccaaaattta gggttgttaagccaaactcattcactttctcgttttcctccgtatcccctcctaatgtattaccgacaagatatcgcca ttaca agatatctctggatatatcacaattggaagcgttgaatatatcatcgacaaagacatttataacggtcaatattgtttt gct gtctcaatatttatctagagtgagtctagaattcattagacgtagtttatcatacgatatgcctccagaagttgtctat ctagt

-100-aaacgcgataatagatagtgctaaacgaattactgaatctattactgactttaatattgatacatacattaatgacctg gt ggaagctgaacacattaaacaaaaatctcagttaacgatcaacgagttcaaatatgaaatgctgcataactttttacct catatgaactatacacccgatcaactaaagggattttatatgatatctttactaagaaagtttctctactgtatctacc aca cttctagatatccagatagagattcgatggtttgtcatcgcatcctaacgtacggcaaatattttgagacgttggcaca tg atgaattagagaattacataggcaacatccgaaacgatatcatgaacaatcacaagaacagaggcacttacgcggt aaacattcatgtactaacaactcctggacttaatcatgcattttctagtctattgagtggaaagttcaaaaagtcagac gg tagttatcgaacacatcctcactattcatg gatg cagaatatttctattcctaggagtgttggattttatccggatcaagtaa agatttcaaagatgttttctgtcagaaaataccatccaagtcaatatctttacttttgttcatcggacgttccggaaag aggt cctcaggtaggtttagtatctcaattgtctgtcttgagttccattacaaatatactaacgtctgagtatttggatttgg aaaag aaaatttgtgagtatatcagatcatattataaagatgatataagttactttgaaacaggatttccaatcactatagaaa at gctctagtcgcatctcttaatccaaatatgatatgtgattttgtaactgactttagacgtagaaaacggatgggattct tcgg taacttggaggtaggtattactttagttagggatcacatgaatgaaattcgcattaatattggagcgggaagattagtc a gaccattcttggttgtggataacggagagctcatgatggatgtgtgtccggagttagaaagcagattagacgacatga cattctctgacattcagaaagagtttccgcatgtcatcgaaatggtagatatagaacaatttacttttagtaacgtatg tga atcggttcaaaaatttagaatgatgtcaaaggatgaaagaaagcaatacgatttatgtgactttcctgccgaatttaga g atggatatgtagcatcttcactagtgggaatcaatcacaattctggacccagagctattcttggatgtgctcaagctaa a caagctatctcttgtctgagctcggatatacgaaataaaatagacaatggaattcatttgatgtatccagagaggccaa t cgtgattagtaaggctttagaaacttcaaagattgcggctaattgcttcggccaacatgttactatagcattaatgtcg tac aaaggtatcaatcaagaggatggaattatcatcaaaaaacaatttattcagagaggcggtctcgatattgttacagcc aagaaacatcaagtagaaattccgttggaaaactttaataacaaagaaagagataggtctaacgcctattcaaaatt agaaagtaatggattagttagactgaatgctttcttggaatccggagacgctatagcacgaaatatctcatcaagaact cttgaagatgattttgctagagataatcagattagctttgatgthccgaaaaatataccgatatgtacaaatctcgcgt tg aacgagtacaagtagaacttactgacaaagttaaggtacgagtattaaccatgaaagaaagaagacccattctagg agacaaatttaccactagaacgagtcaaaagggaacagtcgcgtatatcgcggatgaaacggaacttccatacgat gaaaatggtatcacaccagatgtcattattaattctacatccatcttctctagaaaaactatatctatgttgatagagg ttatt ttaacagccgcatattctg ctaagccgtacaacaataag ggagaaaaccgacctgtctgttttcctagtagtaacgaa acatccatcgatacatatatgcaattcgctaaacaatgttatgagcattcaaatccgaaattgtctgatgaagaattat cg gataaaatcttttgtgaaaagattctctatgatcctgaaacggataagccttatgcatccaaagtattttttggaccaa ttta ttacttgcgtctgaggcatttaactcaggacaaggcaaccgttagatgtagaggtaaaaagacgaagctcattagaca ggcgaatgagggacgaaaacgtggaggaggtatcaagttcggagaaatggagagagactgtttaatagcgcatg gtgcagccaatactattacagaagttttgaaagattcggaagaagattatcaagatgtgtatgthgtgaaaattgtgga gacatagcag cacaaatcaag ggtattaatacatgtcttag atgttcaaaacttaatctctctcctctcttaacaaaaatt g ataccacgcacgtatctaaagtatttcttactcaaatgaacgccagag gcgtaaaagttaaattagatttcgaacgaa ggcctccttcgttttataaaccattagataaagttgatctcaaaccgtcttlictggtgtaatattctagtttggtagt agatac

-101-atatcaatatcatcaaattcgagatccgaattataaaatgggcgtggattgttaactatagaatcggacgtctgatatt cg aaaatctgtggagttttaggttttggtggaggtgtaactgctacttgggatactgaagtctgatattcagaaagctggg gg atgttctggttcgacatccaccgatggtgtcacatcactaatcggttcg gtaacgtctgtggacgatggagg caccactt ctacagglictgglictttatcctcagtcatcaacggagctacttcaatgcgaggaaatgtataatttggtaatggttt ctcat gtggatctgaag aagaggtaagatatctactagaaag ataccgatcacgttctagttctcttttgtagaacttaactttttct ttctccgcatctagttgatattccaacctcttcacgttcgcatgggttacctccgcagtttttacgagcgatttcacgt tcagc cttcatgcgtcttatagcatgaattcgcttatcgttatcgggtttagcttctgtcaccttagcaattccttlittatta aactctaca taatcatatccatttctattgtttgttctaatataaacgagtatagcatcattgctaaatttttcaatagtatcgaaaa cagaat atcctaaaccatataatatatattcaggaacactcaaactaaatgtccaggattctcctaaatacgtaaactttaatag tg cgaaatcattcaaaaatctaccacttatagatag atagatagtacataaatgcgtatagtagtctacctatctctttattatg aaaaccggcattacgatcatatatgtcgtgatatacctgtgatccgtttacgttaaaccataaatacatgggtgatcct at aaacatgaatttatttctaattctcagagctatagttaattgaccgtgtaatatttgcttacatgcatacttgatacga tcatta ataagatlittatcattgctcgttatttcagaatcgtatatataaggagtaccatcgtgattcttaccagatattatac aaaat actatatataaaatatattgacccacgttagtaatcatgtaaatgtttaacgttttaaattttgtattcaatgatccat tatcata cgctagcatggtcttatgatattcattctttaaaatataatattgtgttagccattgcattggggctcctaatggagat tttttatt ctcatccattttaggataggctttcataaagtccctaataacttcgtgaataatgtlictatgttttctactgatgcat gtatttgc ttcgatttttttatcccatgtttcatctatcatagatttaaacgcagtaatgctcgcaacattaacatcttgaaccgtt ggtaca attccgttccataaatttataatgttcgccatttatataactcattttttgaatatacttttaattaacaaaagagtta agttactc atatggacgccgtccagtctgaacatcaatctttttagccagagatatcatagccgctcttagagtttcagcgtgattt tcc aacctaaatagaacttcatcgttgcgtttacaacacttttctatttgttcaaactttgttgttacattagtaatctttt tttccaaatt agttagccgttgtttgagagtttcctcattgtcgtcttcatcggctttaacaattgcttcgcgtttagcctctggcttt ttagcagc cgttgtagaaaaaaattcagttgctggaattgcaagatcgtcatctccggggaaaagagttccgtccatttaaagtaca gattttagaaactgacactctgcgttatttatatttggtacaacacatggattataaatattgatgttaataacatcag aaaa tgtaaagtctatacattgttgcatcgtgttaaattlictaatggatctagtattattgggtccaacttctgcctgaaat ccaaat atggaag cggatacaaaaccgtttcctgg ataaaccacacatctccacttttgctttacatcagaaattgtgtcgttg aca tcttgaactctcctatctaatgccggtgttccacctatagattttgaatattcgaatgctgcatgagtagcattaaatt cctta atattgccataattttcatatattgagtaaccctg gataaaaagtaaacacaccgcagccgtagctaccacaataaaa aaaattgatagagagttcatttataatctattagaagctgacaaaatttttttacacgcatcagacaatgctttaataa ata gttcaacatctacttttgtcatatcgaaccgatggtatgattctaacctagaattacatccgaaaaagttgactatgtt cata gtcattaagtcattaacaaacaacattccagactctggattataagacgatactgtttcgtcacaattacctaccttaa tca tgtgattatgaatattggctattagagcaccttctaagaaatctataatatctttgaaacacgatttaaaatcaaacca cg aatatacttctacgaagaaagttagtttacccataggagaaataactataaatggagatctaaatacaaaatccggat ctatgatagttttaacattattatattctctattaaatacctccacatctaaaaatgttaattttgaaactatgtcttc gtttattac cgtacctgaactaaacgctataagctctattgtttgagaactclitaaacgatattcttgaaatacatgtaacaaagtt tcct

-102-ttaactcggtcgglitatctaccatagttacagaatttgtatccttatctataatataataatcaaaatcgtataaagt tatata attatcgcgttcagattgggatcttttcaaatagactaaaaaccccatttctctagtaagtatcttatgtatatgthgt aaaat atcttcatggtgggaatatgctctaccgcagttagccattcctcattg acagcggtag atgtattagacaaaactattcca atgtttaacaagggccattttacgagattattaaatccttgtttgataaatgtagccaatgagggttcgagttcaacga cg attgaattctcttcccg egg atgctgcatgatgaacgacgggatgttgttcg attgatttgg aattctttttcgactttttgtttat attaaatattttaaaatttatagcggatagcaattcatgtaccacggataatgtagacgcgtattgcgcatcgatatct ttat tattagataaatttatcaataaatgtgagaagtttgcctcgttaaggtcttccatttaaatattatataaacatttgtg tttgtatc ttattcgtcttttatggaatagttttttactagtaaagctgcaattacacactttgtccgtaaaacataaatataaaca ccagc ttttatcaatcgttccaaaaagtcgacggcggacatttttaacatggcatctattttaaatacacttaggttlitggaa aaaa catcattttataattgtaacgattcaataactaaagaaaagattaagattaaacataagggaatgtcatttgtatttta taa gccaaagcattctaccgttgttaaatacttgtctggaggaggtatatatcatgatgatttggttgtattggggaaggta aca attaatgatctaaagatgatgctattttacatggatttatcatatcatg gagtgacaagtagtg gaacaatttacaaattgg gatcgtctatcgatagactttctctaaataggactattgttacaaaagttaataattataattatgatacattttttga cgatga tgattgatcgctattgcacaattttgtttttttactttctaatatagcgtttagattctttttcatgtgcgaatattga tttactaaaat atctatgtttaacttttgttctataacgtccttatcgg cggtatcggtacatatacgtaattcaccttcacaaaatacg gagtc ttcgataataatagccaatcgattattggatctagctgtctgtatcatattcaacatgtttaatatatcctttcgtttc ccctttac aggcatcgatcgtagcatattttccgcgtctgagatggaaatgttaaaactacaaaaatgcgtaatgttagcccgtcct a atattggtacgtgtctataagtttggcatagtagaataatagacgtgtttaaatgccttccaaagtttaagaattctat taga gtattgcattttgatagtttatcgcctacatcatcaaaaataagtaaaaagtgtgctgattttttatgattttgtgcga cagca atacattlitctatgttacttttagttcgtatcagattatattctagagattcctgactactaacgaaattaatatgat ttggcca aatgtatccatcataatctg gattataaacgg gtgtaaacaag aatacatgtttatattttttaactagtgtagaaaacaga gatagtaaatagatagtlittccagatccagatcctcccgttaaaaccattctaaacggcatttttaataaattttctc ttgaa aattgtttttcttggaaacaattcataattatatttacagttactaaattaatttgataataaatcaaaatatggaaaa ctaag gtcgttagtagggaggagaacaaagaaggcacatcgtgacataaataacatttattatcatgatgacaccagaaaa cgacgaagagcagacatctgtgttctccgctactglitacagagacaaaattcagggaaagaataaacgcaaacgc gtgattggtctatgtattagaatatctatggttatttcactactatctatgattaccatgtccgcgtttctcatagtgc gcctaaa tcaatgcatgtctgctaacgaggctgctattactgacgccgctgttgccgttgctgctgcatcatctactcatagaaag gtt g cgtctagcactacgcaatatg atcacaaagaaagctgtaatg gtttatattaccagggttcttgttatatattacattcag actaccagttattctcggatgctaaagcaaattgcactgcggaatcatcaacactacccaataaatccgatgtcttgac t acctggctcattgattatgttaaggatacatggggatctgatggtaatccaattacaaaaactacatccgattatcaag at tctgatgtatcacaagaagttagaaagtatttttgtgttaaaacaatgaactaatatttatttttgtacattaataaat gaaat cgcttaatagacaaactgtaagtaggtttaagaagttgtcggtg ccggtcgctataatgatgatactctcaaccattatta gtggcataggaacatttctgcattacaaagaagaactgatgcctagtgcttgcgccaatggatggatacaatacgata aacattgttatttagatactaacattaaaatgtctacagataatgcggtttatcagtgtcgtaaattacgagccagatt gcc

-103-tagaccggatactagacatctgagagtattglitagtattttttataaagattattgggtaagtttaaaaaagaccaat gat aaatggttagatattaataatgataaagatatagatattagtaaattaacaaattttaaacaactaaacagtacgacgg atgctgaagcgtgttatatatacaagtctggaaaactggttaaaacagtatgtaaaagtactcaatctgtactatgtgt ta aaaaattctacaagtgacaacaaaaaatgaattaataataagtcgttaacgtacgccgccatggacgccgcgtttgtt attactccaatgggtgtgttgactataacagatacattgtatgatgatctcgatatctcaatcatggactttataggac cata cattataggtaacataaaaactgtccaaatagatgtacgggatataaaatattccgacatgcaaaaatgctactttagc tataagggtaaaatagttcctcaggattctaatgatttggctagattcaacatttatagcatttgtgccgcatacagat caa aaaataccatcatcatag catgcgactatgatatcatgttagatatagaagataaacatcag ccattttatctattcccat ctattgatgtttttaacgctacaatcatagaagcgtataacctgtatacagctggagattatcatctaatcatcaatcc ttca gataatctgaaaatgaaattgtcgtttaattcttcattctgcatatcagacggcaatggatggatcataattgatggga aat gcaatagtaattttttatcataaaagttgtaaagtaaataataaaacaataaatattgaactagtagtacgtatattga gc aatcagaaatgatgctg gtacctcttatcacggtgaccgtagttg cgggaacaatattagtatgttatatattatatatttgt aggaaaaagatacgtactgtctataatgacaataaaattatcatgacaaaattaaaaaagataaagagttctaattcc agcaaatctagtaaatcaactgatagcgaatcagactgggaggatcactgtagtgctatggaacaaaacaatgacg tagataatatttctaggaatgagatattggacgatgatagcttcgctggtagtttaatatgggataacgaatccaatgt tat ggcgcctagcacagaacacatttacgatagtgttgctggaagcacgctgctaataaataatgatcgtaatgaacaga ctatttatcagaacactacagtagtacttaatg aagataccaaacagaatcctaactattcatccaatcctttcgtaaatt ataataaaaccagtatttgtagcaagtcaaatccgttcattacagaactcaacaataaatttagtgagaataatccgtt t agacgagcacatagcgatgattatcttaataagcaagaacaagatcatgaacacgatgatatagaatcattggtgtg attagtttcctttttataaaattgaagtaatatttagtattattgctgccgtcacgttgtacaaatggagatattccct gtattcg gcatttctaaaattagcaattttattgctaataatg actgtagatattatatagatacagaacatcaaaaaattatatctgat gagatcaatagacagatggatgaaacggtacttcttaccaacatcttaagcgtagaagttgtaaatgacaatgagatg taccatcttattcctcatagattatcgacgattatactctgtattagttctgtcggaggatgtgttatctctatagata atgacgt caatgg caaaaatattctaacctttcccattg atcatgctgtaatcatatccccactgagtaaatgtgtcgtagttagcaa gggtcctacaaccatattggttgttaaagcggatatacctagcaaacgattggtaacatcgtttacaaacgacatactg t atgtaaacaatctatcactgattaattattcgccgttgtctgtattcattattagacgagttaccgactatttggatag acaca tatgcgatcagatatttgcgaataataagtggtattccattataaccatcgacaataagcagtttcctattccatcaaa ctg tataggtatgtcctctgccaagtacataaattctagcatcgag caagatactttaatacatgtttgtaacctcgag catcc attcgacttagtatacaaaaaaatgcagtcgtacaattctgtacctatcaaggaacaaatattgtacggtagaattgat a atataaatatgagcattagtatttctgtggattaatagatttctagtatggggatcattaatcatctctaatctctaaa tacctc ataaaacgaaaaaaaagctattatcaaatactgtacggaatggattcattctcttctctttttatgaaactctgttgta tatct actgataaaactggaagcaaaaaatctgataaaaagaataagaataagatcaaggattattataaaataacaatag ttcctggttcctcttccacgtctactagctcgtggtattatacacatgcctagtaatagtctctttgcgttgacggaaa gcag actagaaataacaggctaaaatgttcagacaccataatagttcccaacccagataataacagagtaccatcaacac

-104-attcctttaaactcaatcccaaacccaaaaccgttaaaatgtatccggccaattgatagtagataatgaggtgtacagc gcatgatgatttacacagtaaccaaaatgaaaatactttagtaattataagaaatatagatggtaacgtcatcatcaac aatccaataatatgccggagagtaaacattgacggataaaacaaaaatgctccgcataactctatcatggcaataac acaaccaaatacttgtaagattcctaaattagtagaaaatacaacggatatcgatgtataagtgatctcgagaaataat aagaataaagtaatgcccgtaaagataaacatcaacattgtttggtaatcattaaaccaattagtatgaagttgaacta atttcacagtagattttattccagtattatccccgcatgtataagtacctggtaagatatctttatattccataatcaa tgaga catcactatctgataacgaatgaagtctagcactagtatgccatttacttaatattgtcgtcttggaagttttattata agtta aaatatcatggttatccaatttccatctaatatactttgtcggattatctatagtacacggaataatgatggtatcatt acatg ctgtatactctatggtctttgtagttgttataacaaccaacgtatagaggtatatcaacgatattctaactcttgacat tttttatt tatttaaaatgatacctligttatttattttattctattttgctaacggtattgaatggcataagtttgaaacgagtga agaaata atttctacttacttattagacgacgtattatacacgggtgttaatggggcggtatacacattttcaaataataaactaa aca aaactggtttaactaataataattatataacaacatctataaaagtagaggatgcggaaccaataacggaaatccca aatgttggaaaatagacggttcagacgacccaaaacatagaggtagaggatacgctccttatcaaaatagcaaagt aacgataatcagtcacaacggatgtgtactatctgacataaacatatcaaaagaaggaattaaacgatggagaaga tttgacggaccatgtggttatgatttatacacggcg gataacgtaattccaaaagatggtttacgag gagcattcgtcg a taaagatggtacttatgacaaagtttacattcttttcactgatactatcggctcaaagagaattgtcaaaattccgtat ata gcacaaatgtgcctaaacgacgaaggtggtccatcatcattgtctagtcatagatggtcgacgtttctcaaagtcgaat t agaatgtgatatcgacggaagaagttatagacaaattattcattctagaactataaaaacagataatgatacgatacta tatgtattcttcgatagtccttattccaagtccgcattatgtacctattctatgaataccattaaacaatcttlitcta cgtcaaa attggaaggatatacaaagcaattgccgtctccagctcctggtatatgtttaccagctggaaaagttgttccacatacc a cgtttg aagtcatagaaaaatataatgtactag atgatattataaagcctttatctaaccaacctatcttcgaaggaccgt ctggtgttaaatggttcgatataaaggagaaggaaaatgaacatcgggaatatagaatatacttcataaaagaaaatt ctatatattcgttcgatacaaaatctaaacaaactcgtag ctcgcaagtcg atgcg cgactattttcagtaatggtaactt cgaaaccgttatttatagcagatatagggataggagtaggaatgccacaaatgaaaaaaatacttaaaatgtaatctt aatcgagtacaccgcacgacaatgaacaaacataagacag attatgctggttatg cttgctgcgtaatatg cggtcta attgttggaattattlitacagcgacactattaaaagttgtagaacgtaaattagttcatacaccatcaatagataaaa cg ataaaagatgcatatattagagaagattgtcctactgactggataagctataataataaatgtatccatttatctactg atc gaaaaacctgggaggaaggacgtaatgcatgcaaagctctaaatccaaattcggatctaattaagatagagactcc aaacgagttaagttttttaagaagcattagacgcggatattgggtaggagaatccgaaatattaaaccagacaaccc catataattttatagctaaaaatgccacgaagaatggaactaaaaaacggaaatatatttgtagtacaacgaatactc ccaaactacatttttatcataccactacttcggttagatgttttagaaaaaaataaatatcgccgtaccgttcttgttt ttataa aaataacaattaacaattatcaaattttttctttaatattttacgtggttgaccattcttg gtggtaaaataatctcttagtgttg g aatggaatgctgtttaatglitccgcactcatcgtatattttgacgtatgcagtcacatcgtttacgcaatagtcagac tgta gttctatcatgcttcctacatcagaaggaggaacagttttaaagtctcttggttttaatctattgccattagttttcat gaaatc

-105-ctttgttttatccacttcacattttaaataaatgtccactatacattcttctgttaattttactagatcgtcatgggtc atagaattt ataggttccgtagtccatggatccaaactagcaaacttcgcgtatacggtatcgcgattagtgtatacaccaactgtat g aaaattaagaaaacagtttaataaatcaacagaaatatttaatcctccgtttgatacagatgcgccatatttatggatt tc ggattcacacgttgtttgtctgaggtgttcgtctagtgttgcttctacgtaaacttcgattcccatatattctttattg tcagaatc gcataccgatttatcatcatacactgtttgaaaactaaatggtatacacatcaaaataataaataataacgagtacatt ct gcaatattgttatcgtaattggaaaaatagtgttcgagtgagttggattatgtgagtattggattgtatattttatttt atattttat attttgtagtaagaatagaatgctaatgtcaagtttattccaatagatgtcttattaaaaaacatatataataaataac aat ggctgaatggcataaaattatcgaggatatctcaaaaaataataagttcgaggatgccgccatcgttgattacaagac tacaaagaatgttctagctgctattcctaacagaacatttgccaagattaatcctctcatcactaatcgtaatattcta aaa cctcttattggtcagaaatattgtattgtatatactaactctctaatggatgagaacacgtatgctatggagttgctta ctgg gtacgcccctgtatctccgatcgttatagcgagaactcataccgcacttatatttttgatgggtaagccaacaacatcc a gacgtgacgtgtatagaacgtgtagagatcacgctacccgtgtacgtgcaactggtaattaaaataaaaagtaatatt catatgtagtgtcaattttaaatgatgatgatgaaatggataatatccatattgacgatgtcaataatgccg gtattgg cat acagttcatcgatttttagatttcattcagaggatgtggaattatgttatgggcatttgtattttgataggatctataa tgtagta aatataaaatataatccgcatattccatatagatataattttattaatcgcacgttaaccgtagatgaactagacgata at gtcttttttacacatggttattttttaaaacacaaatatgglicacttaatcctagtttgattgtctcattatcaggaa acttaaa atataatgatatacaatgctcagtaaatgtatcgtgtctcattaaaaatttggcaacgagtacatctactatattaaca tct aaacataagacttattctctacatcggtccacgtgtattactataataggatacgattctattatatggtataaagata taa atgacatctatgattttactgcaatatgtatgctaatagcgtctacattgatagtgaccatatacgtgtttaaaaaaat aaa aatgaactcttaattatgctatgctattagaaatggataaaatcaaaattacggttgattcaaaaattggtaatgttgt tacc atatcgtataacttggaaaagataactattgatgtcacacctaaaaagaaaaaagaaaaggatgtattattagcgcaa tcagttgctgtcgaagaggcaaaagatgtcaaggtagaagaaaaaaatattatcgatattgaagatgacgatgatat ggatgtagaaagcgcataatacgatctataaaaataagtatataaatactttttatttactgtactcttactgtgtagt ggtg ataccctactcgattatttttttaaaaaaaaatacttattctgattcttctagccatttccgtgttcgttcgaatgcca catcgac gttaaagataggggagtagttgaaatctagttctgcattgttggtacgcacctcaaatgtagtgttggatatclicaac gta tagttgttgagtagtgatggttttctaaatagaattctcttcatatcattcttgcacgcgtacatttttagcatccatc ttggaatc ctagatccttgttctattcccaatggtttcatcaatag aagattaaacatatcgtacgaacacgatggag agtaatcgtag caaaagtaagcatttcctttaatctcagatcccggatactggatatattttgcagccaacacgtgcatccatgcagcat tt cctacatatacccggctatgtaccgcgttatcatcgactgtacgatacataatgttaccgtgttgcttacattgctcgt aaa agactttcatcaatttgtctccttctccgtaaattccagtgg gtcttaggcaacaagtatacaattttgctccattcatg attac ggaattattggctttcataaccagttgctcggccatacgtttactttttgcgtatacatgtcctggtgatatatcataa agggt atgctcatggccgatgaatggatcaccgtgtttattgggtcctattgcttccatgctactagtatagatcaaatacttg attc ctaggtccacacaagctgccaatatagtctgtgttccataatagtttactttcatgatttcattatcggtgtattttcc aaatac atccactagagcagctgtatgaataatcagatttaccccatctag cgcttctcttaccttatcaaagtcgtttatatcacatt

-106-gtatatagtttataaccttaactttcgaggttattggttgtggatcttctacaatatctatgactctgatttcttgaac atcatctg cactaattaacagtttta ctatatacctg cctag a aatccg gcaccaccagtaaccg cgtacacggccattg ctgccac tcataatatcagactacttattctattttactaaataatggctgtttgtataatagaccacgataatatcagaggagtt attta ctttgaaccagtccatggaaaagataaagttattggattaaaatccggaacgtatagtttgataattcatcgttacgga g atattagtcaag gatgtgattccatagg cagtccagaaatatttatcggtaacatctttgtaaacagatatggtgtag cat atgtttatttagatacagatgtaaatatatctacaattattggaaaggcgttatctatttcaaaaaatgatcagagatt ag c gtgtggagttattggtatttcttacataaatgaaaagataatacattttcttacaattaacgagaatggcgtttgatat atca gttaatgcgtctaaaacaataaatgcattagtttacttttctactcagcaaaataaattagtcatacgtaatgaagtta atg atacacactacactgtcgaatttgatagggacaaagtagttgacacgtttatttcatataatagacataatgactccat ag agataagaggggtgcttccagaggaaactaatattggttgcgcggttaatacgccggttagtatgacttacttgtataa t aagtatagttttaaactgattttag cagaatatataagacacagaaatactatatccgg caatatttattcggcattgatga cactagatgatttggctattaaacagtatggagacattgatctattatttaatgagaaacttaaagtagactccgattc gg gactatttgactttgtcaactttgtaaaggatatgatatgttgtgattctagaatagtagtagctctatctagtctagt atctaa acattgggaattgacaaataaaaaatataggtgtatggcattagccgaacatatatctgatagtattccaatatctgag c tatctagactacgatacaatctatgtaagtatctacgcgg gcacactgag agcatagaggatg aatttgattattttgaa gacgatgattcgtctacatgttctgccgtaaccgacagggaaacggatgtataattttlittatagcgtgaaggatatg at aaaaaatataattgttgtatttatcccattccaatcaccttatatgattctgtaacacaatgaaggagtcttatagatg tata gaggtcagatactggtttgataaactglitattccacataagtatgtttgactttatggttagacccgcatactttaac aaatc actgaaaattggagttaggtattgacctctcagaatcagttgccgttctggaacattaaatgtattttttatgatatac tcca acgcatttatgtgggcatacaacaagtcattactaatggagtattccaagagaagagatttcaacagactgtttatgaa ctcgaatgccgcctcattgtcgcttatattgatgatgtcgaattctcccaatatcatcaccgatgagtagctcatcttg ttatc gggatccaagttttctaaagatgtcattaaaccctcgatcatgaatggatttatcatcatcgtttttatgttggacatg agctt agtccgtttgtccacatctatagacgacgatttctgaattatttcatatatccctctclitaactccaggaacttgtca ggatg gtctactttaatatglictcgtctaagagatgaaaatctttggatggttgcacgcgacttttctctaaaggatcctctc ttaaat gaatccatcttatccttggacaagatggacagtctattttccttagatggtttaatatttttgttacccatgatctata aaggta g acctaatcgtctcg gatgaccatatatttattttcagttttattatacg cataaattgtaaaaaatatgttaggtttacaaaa atgtctcgtg gggcattaatcgtttttgaaggattggacaaatctg gaaaaacaacacaatgtatgaacatcatggaat ctataccggcaaacacgataaaatatcttaactttcctcagag atccactgtcactg gaaagatgatagatgactatct aactcgtaaaaaaacctataatgatcatatagttaatctattattligtgcaaatagatgggagtttgcatcttttata caag aacaactagaacagggaattactttaatagttgatagatacgcattctctggagtagcgtatgccgccgctaaaggcg cgtcaatgactctcagtaagagttatgaatctggattgcctaaacccgacttagttatattcttggaatctggtagcaa ag aaattaatagaaacgtcggcgaggaaatttatgaagatgttacattccaacaaaaggtattacaagaatataaaaaa atgattgaagaaggagatattcattggcaaattatttcttctgaattcgaggaagatgtaaagaaggagttgattaaga a tatagttatagaggctatacacacggttactggaccagtggg gcaactgtgg atgtaatagtgaaattacattttttataa

-107-atggatgaagcatattactctggcaacttggaatcagtactcggatacgtgtccgatatgcataccgaactcgcatcaa tatctcaattagttattgccaagatagaaactatagataatgatatattaaacaaggacattgtaaattttatcatgtg tag atcaaacttgg ataatccatttatctctttcctagatactgtatatactattatagatcaagagatctatcagaccgaattg at taattcattagacgacaatgaaattatcgattgtatagttaacaagtttatgagcttttataaggataacctagaaaat ata gtagatgctatcattactctaaaatatataatgaataatccagattttaaaactacgtatgccgaagtactcggttcca ga atagcggatatagatattaaacaagtgatacgtgagaatatactacaattgtctaataatatccgcgaacgatatttgt g aaaatattaaaaaaaaatacttlitttattaaatgacgtcgcttcgcgaatttagaaaattatgctgtgatatatatca cgca tcag gatataaagaaaaatctaaattaattagagactttataacagatag ggatgataaatatttgatcattaagctattg cttcccggattagacgatagaatttataacatgaacgataaacaaattataaaattatatagtataatatttaaacaat ct caggaagatatgctacaagatttaggatacggatatataggagacactattaggactlicttcaaagagaacacaga aatccgtccacgagataaaagcattttaactttagaag aagtggatagttttttaactacgttatcatccgtaactaaaga atcgcatcaaataaaattattgactgatatcgcatccgtttgtacatgtaatgatttaaaatgtgtagtcatgcttatt gataa agatctaaaaattaaagcgggccctcggtacgtacttaacgctattagtcctcatgcctatgatgtgtttagaaaatct aa taacttgaaagagataatagaaaatgcatctaaacaaaatctagactctatatctatttctgttatgactccaattaat ccc atgttag cggaatcgtgtgattctgtcaataaggcgtttaaaaaatttccatcaggaatgtttgcggaagtcaaatacg at ggtgaaagagtacaagttcataaaaataataacgagtttgccttctttagtagaaacatgaaaccagtactctctcata aagtggattatctcaaagaatacataccgaaagcatttaaaaaagctacgtctatcgtattggattctgaaattgttct tgt agacgaacataatgtaccgctcccgtttggaagtttaggtatacacaaaaagaaagaatataaaaactctaacatgt gtttgttcgtgtttgactgtttgtactttgatg gattcgatatgacggacattccattgtacgaacgaagatcttttctcaaaga tgttatggttgaaatacccaatagaatagtattctcagagttgacgaatattagtaacgagtctcagttaactgacgta ttg gatgatgcactaacgagaaaattagaaggattggtcttaaaagatattaatggagtatacgaaccgggaaagagaa gatggttaaaaataaagcgagactatttgaacgagggttccatggcagattctgccgatttagtagtactaggtgctta c tatggtaaaggagcaaagggtggtatcatggcagtctttctaatgggttgttacgacgatgaatccggtaaatggaaga cggttaccaagtgttcaggacacgatgataatacgttaagggagttgcaagaccaattaaagatgattaaaattaaca aggatcccaaaaaaattccagagtggttagtagttaataaaatctatattcccgattttgtagtagaggatccaaaaca atctcagatatgggaaatttcaggagcagagtttacatcttccaagtcccataccgcaaatggaatatccattagattt c ctagatttactaggataagagaggataaaacgtggaaagaatctactcatctaaacgatttagtaaacttgactaaatc ttaatagttacatacaaattaaaataacactatttagttg gtggtcgccatggatggtgttattgtatactgtctaaacgcgtt agtaaaacatggcgaggaaataaatcatataaaaaatgatttcatgattaaaccatgttgtgaaaaagtcaagaacg ttcacattgg cgg acaatctaaaaacaatacagtg attgcagatttgccatatatggataatgcg gtatccgatgtatg c aattcactgtataaaaagaatgtatcaagaatatccagatttgctaatttgataaagatagatgacgatgacaagactc ctactggtgtatataattattttaaacctaaagatgccattcctgttattatatccataggaaaggatagagatgtttg tgaa ctattaatctcatctgataaagcgtgtgcgtgtatagagttaaattcatataaagtagccattcttcccatggatgttt ccttttt taccaaaggaaatgcatcattgattattctcctgtttgatttctctatcgatgcggcacctctcttaagaagtgtaacc gata

-108-ataatgttattatatctagacaccagcgtctacatgacgagcttccgagttccaattggttcaagttttacataagtat aaa gtccgactattgttctatattatatatggttgttgatggatctgtgatgcatgcaatagctgataatagaacttacgca aatat tagcaaaaatatattagacaatactacaattaacgatgagtgtagatgctgttattttgaaccacagattaggattctt gat agagatgagatgctcaatggatcatcgtgtgatatgaacagacattgtattatgatgaatttacctgatgtaggcgaat tt ggatctagtatgttggggaaatatgaacctgacatgattaagattgctctttcggtggctggtatttggaaagttttat aggt agttgatagaacaaaatacataattttgtaaaaataaatcactttttatactaatatgacacgattaccaatacttttg ttact aatatcattagtatacgctacaccttttcctcagacatctaaaaaaataggtgatgatgcaactttatcatgtaatcga aat aatacaaatgactacgttgttatgagtgcttggtataaggagcccaattccattattcttttagctgctaaaagcgacg tctt gtattttgataattataccaaggataaaatatcttacg actctccatacgatg atctagttacaactatcacaattaaatcat tgactgctagagatgccggtacttatgtatgtgcattctttatgacatcgcctacaaatgacactgataaagtagatta tga agaatactccacagagttgattgtaaatacagatagtgaatcgactatagacataatactatctggatctacacattca c cggaaactagttctgagaaacctgattatatagataattctaattg ctcgtcggtattcgaaatcgcg actccg gaacca attactgataatgtagaagatcatacagacaccgtcacatacactagtgatagcattaatacagtaagtgcatcatctg gagaatccacaacagacgagactccggaaccaattactgataaagaagaagatcatacagttacagacactgtct catacactacagtaagtacatcatctg gaattgtcactactaaatcaaccaccgatgatgcgg atctttatgatacgtac aatgataatgatacagtaccatcaactactgtaggcggtagtacaacctctattagcaattataaaaccaaggactttg t agaaatatttggtattaccgcattaattatattgtcggccgtg gcaatattctgtattacatattatatatataataaacgttca cgtaaatacaaaacagagaacaaagtctagatttttgacttacataaatgtctgggatagtaaaatctatcatattgag c gggccatctggtttaggaaagacagccatagccaaaagactatgggaatatatttggatttgtggtgtcccataccact agatttcctcgtcctatggaacgagaaggtgtcgattaccattacgttaacagagaggccatctggaagggaatagcc gccggaacatactgagtttttaggaaatatttacggaacttctaaaactgctgtgaatacagcggctattaataatcgt at ttgtgtgatggatctaaacatcgacggtgttagaagttttaaaaatacttacctaatgccttactcggtgtatataaga cct acctctcttaaaatggttgagaccaagcttcgttgtagaaacactgaagcggatgatgagattcatcgtcgtgtgatgt tg g caaaaactgacatg gatgag gcaggtgaag ccggtctattcgacactattatcattgaagatgatgtgaatttag cat atagtaagttaattcagatactacaggaccgtattagaatgtattttaacactaattagagacttaagacttaaaactt g at aattaataatataactcgtttttatatgtggctatttcaacgtctaatgtattagttaaatattaaaacttaccacgta aaactt aaaatttaaaatgatatttcattgacagatagatcacacattatgaactttcaaggacttgtgttaactgacaattgca aa aatcaatgggtcgttggaccattaataggaaaaggtggatttggtagtatttatactactaatgacaataattatgtag ta aaaatagagcccaaagctaacggatcattatttaccgaacaggcattttatactagagtacttaaaccatccgttatcg aagaatggaaaaaatctcacaatataaagcacgtaggtcttatcacgtgcaaggcatttggtctatacaaatccattaa tgtggaatatcgattcttggtaattaatagattaggtgcagatctagatgcggtgatcagagccaataataatagatta cc aaaaaggtcggtgatgttgatcggaatcgaaatcttaaataccatacaatttatgcacgagcaaggatattctcacgg agatattaaagcgagtaatatagtcttggatcaaatagataagaataaattatatctagtggattacggattggtlict aa attcatgtctaatggcgaacatgttccatttataag aaatccaaataaaatggataacggtactctag aatttacacctat

-109-ag attcgcataaaggatacgttgtatctagacgtggagatctagaaacacttgg atattgtatg attagatggttgg gag gtatcttgccatggactaagatatctgaaacaaagaattgtgcattagtaagtgccacaaaacagaaatatgttaaca atactgcgactligttaatgaccagtttgcaatatgcacctagagaattgctgcaatatattaccatggtaaactcttt gac atattttgaggaacccaattacgacaagtttcggcacatattaatgcagggtgtatattattaagtgtggtgtttggtt gatgt aaaatttttgtcgataaaaattaaaaaataacttaatttattattgatctcgtgtgtacaaccgaaatcatggcgatgt tttac gcacacgctctcggtgggtacgacgagaatcttcatgcctttcctggaatatcatcgactgttgccaatgatgtcagtt tat aataacaagtatgacattgtaaaagacaaatatatgtggtgttacagtcaggtgaacaagagatatattggagcactg ctgcctatgtttgagtgcaatgaatatctacaaattg gagatccgatccatgatcaagaag gaaatcacatatcg ccac aaaaactactatgctctaagcggaatcgggtacgagagtctagacttgtgtttggaaggagtagggattcatcatcac gtacttgaaacagaaaacgctgtatatggaaaagttcaacatgattattctactatcaaagagaaggccaaagaaat gaatgcactcagttcaggacctatcatcgattaccacgtctggataggagattgtatctgtcaagttactgctgtggac gt acatggaaaggaaattatgagaatgagattcaaaaagggtgcggtgcttccgatcccaaatctggtaaaagttaaac ttggggagaatgatacagaaaatctttcttctactatatcgg cggcaccatcg aggtaaccacctctctgg aagacagt gtgaatcatgtactcatgaaacgtttgg aatctatacg ccatatgtggtctgttgtatatgatcattttgatattgtg aatggta aagaatgctgttatgtgcatacgcatttgtctaatcaaaatcttataccgagtactgtaaaaacaaatttgtacatgaa ga ctatgg gatcatgcattcaaatgagtatcttag cgaactgaaggaatcaggtg gatggagtcccagaccagaaatgc aggaatttgaatatccagatggagtggaagacactgaatcaattgagagattggtagaggagttcttcaatagatcag aacttcaggctggtaaatctattaatgttaaacatacatctgtttcagctaagcaactaagaacacgtatactctcatc tttt gccaacacagagggtggatatttgttcattggagttgataataatacacacaaagtatttggattcacggtgggttacg a ctacctcagactgatagagaatgatatagaaaagcatatcaaaagactttgtgttgtgtatttctgtgagaagaaagag gacatcaagtacacgtgtcgattcatcaaggtatataaacctgggg atgaggctacctcgacatacgtgtgcgctatc aaagtggaaagatgctgttgtgctgtgtttg cag attggccagaatcatggtatcaagaagtattctccag atgaatagg tgtcacatataaaattttaattaatgtaactatagagaacaaataataggttgtaatatcatatagacaataactaaca at taattagtaactgttatctctttttaactaactaactatacctattaatacatcgtaattatagttcttaacatctatt aatcattga ttcgcttctttaattttttataaaccaacattgttaattg aaaagggataacatgttacagaatataaattatatatggattttttt taaaaaggaaatacttgactggagtgtatatttatctcttcattatatagcacgcgtgttttccaatttttccacatcc catata atacaggattataatctcgttcgaacatacgagaaagtggataaaacaatagttgattttttatctaggttgccaaatt tatt ccatattttagaatatggggaaaatattctacatatttattctatggatgatgctaatacgaatattataatttttttt ctagata gagtattaaatattaataagaacgggtcatttatacacaatctcaggttatcatcatccattaatataaaagaatatgt ata tcaattagttaataatgatcatccagataataggataagactaatg cttgaaaatggacgtagaacaagacattttttgtc ctatatatcagatacagttaatatctatatatgtattttatatagatgccgaagacagttacggttgtacattattaca tagat gtatatatcactataagaaatcagaatcagaatcagaatcatacaatgaattaattaagatattgttaaataatggatc a gatgtagataaaaaagatacgtacggaaacacaccttttatcctattatgtaaacacgatatcaacaacgtggaattgt ttgagatatgtttagagaatgctaatatagactctgtagactttaatagatatacacctclicattatgtctcatgtcg taata

-110-aatatgattttgtaaagttattaatttctaaaggagcaaatgttaatgcgcgtaataaattcggaactactccatttta ttgtg gaattatacacggtatctcgcttataaaactatatttggaatcagacacagagttagaaatagataatgaacatatagt t cgtcatttaataatttttgatgctgttgaatctttagattatctattatccagaggagttattgatattaactatcgta ctatttacg acgctgtcagttataatgcgtataatacgttggtctatctattaaacagaaatggtgattttgagacgattactactag tgg atgtacatgtatttcggaagcagtcgcaaacaacaacaaaataataatggaagtactattgtctaaacgaccatctttg aaaattatgatacagtctatgatagcaattactaaacataaacagcataatgcagatttattgaaaatgtgtataaaat a tactgcgtgtatgaccgattatgatactcttatagatgtacaatcactacagcaatataaatggtatattttaagatgt ttcg atgaaatagatatcatgaagagatgttatataaaaaataaaactgtattccaattagttttttgtatcaaagacattaa tac tttaatgagatacggtaaacatccttctttcgtgaagtgcactagtctcgacgtatacggaagtcgtgtacgtaatatc ata gcatctattagatatcgtcagagattaattagtctattatccaagaagctggatcctggagataaatggtcgtgttttc cta acgaaataaaatataacgataacgaactgtccacatatctaaaaatcttataaacactattaaaatataaaatcacact acatcattgtttccttttagtgctcgacagtgtatactatttttaacgctcataaataaaaatgaaaacgatttccgtt gttacg ttgttatgcgtactacctgctgttgtttattcaacatgtactgtacccactatgaataacgctaaattaacgtctaccg aaac atcgtttaataataaccagaaagttacgtttacatgtgatcagggatatcattcttcggatccaaatgctgtctgcgaa ac agataaatggaaatacgaaaatccatgcaaaaaaatgtgcacagtttctgattacatctctgaactatataataaacc gctatacgaagtgaattccaccatgacactaagttgcaacggcgaaacaaaatattttcgttgcgaagaaaaaaatg gaaatacttcttggaatgatactgttacgtgtcctaatgcggaatgtcaacctcttcaattagaacacggatcgtgtca ac cagttaaagaaaaatactcatttggggaatatataactatcaactgtgatgttggatatgaggttattggtgcttcgta cat aagttgtacagctaattcttggaatgttattccatcatgtcaacaaaaatgtgatataccgtctctatctaatggatta atttc cggatctacattttctatcggtggcgttatacatcttagttgtaaaagtggttttatactaacgggatctccatcatcc acatg tatcgacggtaaatggaatcccatactcccaacatgtgtacgatctaacgaaaaatttgatccagtggatgatggtccc gacgatgagacagatttgagcaaactctcgaaagacgttgtacaatatgaacaagaaatagaatcgttagaagcaa cttatcatataatcatagtggcgttaacaattatgggcgtcatatttttaatctccgttatagtattagtligttcctg tgacaaa aataatgaccaatataagttccataaattgctaccgtgaatataaatccgttaaaataatgaataattaataattaata att taataacaaacaagtatcaaaagattaaagacttatagctagaatcaattgagatgtcttcttcagtggatgttgatat ct acgatgccgttagagcatttttactcaggcactattataacaagagatttattgtgtatggaagaagtaacgccatatt ac ataatatatacaggctatttacaagatgcgccgttataccgttcgatgatatagtacgtactatgccaaatgaatcacg tg ttaaacaatgggtgatggatacacttaatggtataatgatgaatgaacgcgatgtttctgtaagcgttggcaccggaat a ctattcatggaaatgtttttcgattacaataaaaatagtatcaacaatcaactaatgtatgatataattaatagcgtat ctat aattctagctaatgagagatatagaagcgclittaacgacgatggtatatacatccgtagaaatatgattaacaagttg t acggatacgcatctctaactactattggcacgatcgctggaggtgtttgttattatctgttgatgcatctagttagttt gtataa ataattatttcaatatactagttaaaattttaagattttaaatgtataaaaaactaataacgtttttatttgtaatagg tgcatta gcatcctattcgaataatgagtacactccgtttaataaactgagtgtaaaactctatatagatggagtagataatatag a aaattcatatactgatgataataatgaattggtgttaaattttaaagagtacacaatttctattattacagagtcatgc gacg

-111-tcggatttgattccatagatatagatgttataaacgactataaaattattgatatgtctactattcaacgcagaggtca cac gtgtagaatatctaccaaattatcatgccattatgataagtacccttatattcacaaatatgatggtgatgagcgacaa ta ttctattactgcagagggaaaatgctataaaggaataaaatatgaaataagtatgatcaacgatgatactctattgaga aaacatactcttaaaattggatctacttatatatttgatcgtcatggacatagtaatacatattattcaaaatatgatt tttaaa aatttaaaatatattatcacttcagtgacagtagtcaaataacaaacaacaccatgagatatattataattctcgcagt ttt gttcattaatagtatacacgctaaaataactagttataagtttgaatccgtcaattttgattccaaaattgaatggact ggg gatggtctatacaatatatcccttaaaaattatggcatcaagacgtggcaaacaatgtatacaaatgtaccagaagga acatacgacatatccgcatttccaaagaatgatttcgtatctttctgggttaaatttgaacaaggcgattataaagtgg aa gagtattgtacgggaccaccgactgtaacattaactgaatacgacgaccatccgtatgctactagaggtagcaaaaa gattcctatttacaaacgcggtgacatgtgtgatatctacttgttgtatacggctaacttcacattcggagattctaaa gaa ccagtaccatatgatatcgatgactacgattgcacgtctacaggttgcagcatagactttgtcacaacagaaaaagtgt gcgtgacagcacagggagccacagaagggtttctcgaaaaaattactccatggagttcgaaagtatgtctgacacct aaaaagagtgtatatacatgcgcaattagatccaaagaagatgttcccaatttcaaggacaaaatggccagagttat caagagaaaatttaactaaatttctcggtagcacatcaaatgatgttaccacttttcttagcatgcttaacttgactaa atat tcataactaatttttattaatgatacaaaaacgaaataaaactgcatattatacactggttaacgcccttataggctct aac cattttcaagatgaggtccctgattatagtccttctgttcccctctatcatctactccatgtctattagacgatgtgag aagac tgaagaggaaacatggggattgaaaatagggttgtgtataattgccaaagatttctatcccgaaagaactgattgcagt gttcatctcccaactgcaagtgaaggcaatggattcagggatatacgaaacaccgataaattataaaaaaagcaatg tgtccgctgtttccgttaataatactattttcgtaactggcggattattcataaataactctaatagcacgatcgtggt taaca atatggaaaaacttgacatttataaagacaaacaatggtcgattatagaaatgcctatggctagggtatatcacggcat cgactcgacatttggaatgttatattttgccggaggtctatccgttaccgaacaatatggtaatttagagaaaaacaac g agatatcttgttacaatcctagaacgaataagtggtttgatatttcatatactatttataagatatccatatcatcatt gtgtaa actaaataacgtcttctatgtatttagtaaggacattggatatgtggaaaagtatgatggtctccccgctataaaggca tt atcaacttctccttattgattgaaaatgaaaatataaatagtttttatgtatagcagtattaccctatagttttattgc ttactact aacatggatacagatacagatgttacaaatgtagaagatatcatgaatgaaatagatagagagaaagaagaaata ctaaaaaatgtagaaattgaaaataataaaaacattaacaagaatcatcccaatgaatatattagagaagcactcgtt attaatacaagtagtaatagtgattccattgataaagaagttatagaatgtatcagtcacgatgtaggaatatagatca t atctactaatttttataatcaatacaaaacataaaaaacaactcgttattacatagcaggcatggaatccttcaagtat tgt tttgataacgatggcaagaaatggattatcggaaatactttatattctggtaattcaatactctataaggtcagaaaaa att tcactagttcgttctacaattacgtaatgaagatagatcacaaatcacacaagccattgttgtctgaaatacgattcta tat atctgtattggatcctttgactatcgacaactggacacgggaacgtggtataaagtatttggctattccagatctgtat gga attggagaaaccgatgattatatgttcttcgttataaagaatttgggaagagtattcgccccaaaggatactgaatcag t cttcgaagcatgcgtcactatgataaacacgttagagtttatacactctcgaggatttacccatggaaaaatagaaccg aggaatatactgattagaaataaacgtctlicactaattgactattctagaactaacaaactatacaagagtggaaact

-112-cacatatagattacaacgaggacatgataacttcaggaaatatcaattatatgtgtgtagacaatcatcttggagcaac agtttcaaaacgaggagatttagaaatgttgggatattgcatgatagaatggttcggtggcaaacttccatggaaaaac gaaagtagtataaaagtaataaaacaaaaaaaagaatataaaaaatttatagctactlictttgaggactgttttcctg a aggaaatgaacctctggaattagttagatatatagaattagtatacacgttagattattctcaaactcctaattatgac ag actacgtag actgtttatacaagattgaaatattctttttttatag agtgtggtagtgttacggatatctaatattaatattaga ctatctctatcg cg ctacacgaccaatatcgattactatggatatcttctatg aaaggag agaatgtattcatttctccagc gtcaatctcgtcagtattg acaatactgtattatggag ctaatg gatccactgctgaacagctatcaaaatatgtagaaa aggaggagaacacggataaggttagcgctcagaatatctcattcaaatccatgaataaagtatatgggcgatattctg ccgtgtttaaagattcctttttg agaaaaattggcgataagtttcaaactgttgacttcactgattgtcg cactatagatgca atcaacaagtgtgtagatatctttactgaggggaaaatcaatccactattggatgaacaattgtctcctagcaattagt gc cgtatactttaaagcaaaatggttgacgccattcgaaaaggaatttaccagtgattatcccttttacgtatcaccaacg g aaatggtagacgtaagtatgatgtctatgtacggcgagctatttaatcacgcatctgtaaaagaatcattcggtaactt tt caatcatagaactgccatatgttggagatactagtatgatggtcattcttccagacaagattgatggattagaatccat a gaacaaaatctaacagatacaaattttaagaaatggtgtaactctctggaagctacgtttatcgatgttcacattccca a gtttaaggtaacaggctcgtataatctggtggatactctagtaaagtcaggactgacagaggtgttcggttcaactgga gattatag caatatgtgtaatttagatgtg agtgtcgacg ctatgatccacaaaacgtatatagatgtcaatgaagagtat acagaagcagctgcagcaacttgtgcactggtgtcagactgtgcatcaacaattacaaatgagttctgtgtagatcatc cgttcatctatgtgattaggcatgttgatgg aaaaatttttttcgttggtagatattg ctctccgacaactaattgttaaccattt tttttaaaaaaatagaaaaaacatgtggtattagtgcaggtcgttattcttccaattgcaattggtaagatgacggcca ac tttagtacccacgtcttttcaccacag cactgtggatgtg acag actg a ccagtattg atg acg tcaaa ca atgtttg a ct gaatatatttattggtcgtcctatgcataccgcaacaggcaatgcg ctggacaattgtattccacactcctctcttttag ag atgatgcggaattagtgttcatcgacattcgcgagctggtaaaaaatatgccgtgggatgatgtcaaagattgtgtaga aatcatccgttgttatataccggatgagcaaaaaaccatcatcggactttgtgcatatgctgctacttactggggaggt g aagaccatcccactagtaacagtctgaacgcattgtttgtgatgcttgagatgctaaattacgtggattataacatcat att ccggcgtatgaattgatgagttgtacatcttgacattttcttctttcttctcttctccctttcccagaaacaaactttt tttacccac tataaaataaaatgagtatactacctgttatatttctlictatatttttttattcttcattcgttcagactlitaacgc gcctgaatgt atcgacaaagggcaatattttgcatcattcatggagttagaaaacgagccagtaatcttaccatgtcctcaaataaata cgctatcatccggatataatatattagatattttatgggaaaaacg aggagcggataatg atagaattataccgatag at aatggtagcaatatgctaattctgaacccgacacaatcagactctggtatttatatatgcattaccacgaacgaaacct actgtgacatgatgtcgttaaatttgacaatcgtgtctgtctcagaatcaaatatagatcttatctcgtatccacaaat agta aatgagagatctactggcgaaatggtatgtcccaatattaatgcatttattgctagtaacgtaaacgcagatattatat gg agcgggcatcgacgccttagaaataagagacttaaacaacggacacctggaattattaccatagaagatgttagaa aaaatgatgctggttattatacatgtgttttagaatatatatacggtggcaaaacatataacgtaaccagaattgtaaa at tagaggtacgggataaaataataccttctactatgcaattaccagaaggtgttgtaacttcaataggtagtaatttgac ta

-113-ttgcgtgtagagtatcgttgagacctcccacaacggatgcagacgtcttttggataagtaatggtatgtattacgaaga a gatgatggggacggagacggtagaataagtgtagcaaataaaatctatatgaccgataagagacgtgttattacatc ccggttaaacattaatcctgtcaaggaagaagatgctacaacgtttacgtgtatggcgtttactattcctagcatcagc a aaacagttactgttagtataacgtgaatgtatgttgttacatttccatgtcaattgagtttataagaatlittatacat tatcttcc aacaaacaattgacgaacgtattgctatgattaactcccacgatactatgcatattattaatcattaacttgcagacta ta cctagtgctattttgacatactcatgttcttgtgtaattgcggtatctatattattaaagtacgtaaatctagctatag ttttattat ttaattttagataatataccgtctccttattlitaaaaattgccacatcctttattaaatcatgaatgggaatttctat gtcatcgtt aatatattgtgaacaacaagagcagatatctataggaaagggtggaatgcgatacattgatctatgtagttttaaaaca cacgcgaactttgaagaatttatataaatcattccatcgatacatccttctatgttgacatgtatatatccaggaattc ttttat taatgtcaggaaatgtataaactaaaacattgcccgaaagcggtgcctctatctgcgttatatccgttcttaacttaca aa atgtaaccaatacctttgcatgacttgttttgttcggcaacgttagtttaaacttgacgaatggattaattacaatagc atga tccgcgcatctattaagtttttttactttaacgcccttgtatgtttttacagagactttatctaaatttctagtgcttg tatgtgttata aatataacgggatatagaactgaatcacctaccttagatacccaattacattttatcagatccagataataaacaaatt tt gtcgccctaactaattctatattgttatatattttacaattggttatgatatcatgtaataacttggagtctaacgcgc atcgtc gtacgtttatacaattgtgatttagtgtagtatatctacacatgtatttttccgcactatagtattctggactagtgat aaaact atcgttatatctgtcttcaatgaactcatcgagatattgctctctgtcatattcatacacctgcataaactttctagac atctta caatccgtgttattttaggatcatatttacatatttacgggtatatcaaagatgttagattagttaatgggaatcgtct ataata atgaatattaaacaattatatgaggacttttaccacaaagcatcataaaaatgagtcgtcgtctgatttatgttttaaa tatc aaccgcgaatcaactcataaaatacaagagaatgaaatatatacatattttagtcattgcaatatagaccatacttcta c agaacttgattttgtagttaaaaactatgatctaaacagacgacaacctgtaactgggtatactgcactacactgctat tt gtataataattactttacaaacgatgtactgaagatattattaaatcatggagtggatgtaacgatgaaaaccagtagc g gacgtatgcctgthatatattgcttactagatgligtaatatttcacatgatgtagtgatagatatgatagacaaagat aaa aaccacttatcgcatagagactattccaacctactactagagtatataaaatctcgttacatgttattgaaggaagagg a tatcgatgagaacatagtatccactttattagataagggaatcgatcctaactttaaacaagacggatatacagcgtta c attattattatttgtgtctcgcacacgtttataaaccaggtgagtgtagaaaaccgataacgataaaaaaggccaagcg aattatttctttglitatacaacatggagctaatctaaacgcgttagataattgtggtaatacaccattccatttgtat cttagt attgaaatgtgtaataatattcatatgactaaaatgctgttgacttttaatccgaatttcaaaatatgtaataatcatg gatta acgcctatactatgttatataacttccgactacatacaacacgatattcttgttatgttaatacatcactatgaaacaa atgt tggagaaatgccgatagatgagcgtcgtataatcgtattcgagtttatcaaaacatattctacacgtccggcagattcg a taacttatttgatgaataggtttaaaaatatagatatttatacccgctatgaaggaaagacattattacacgtagcatg tga atataataatacacacgtaatagattatcttatacgtatcaacggagatataaatgcgttaaccgacaataacaaacac gctacacaactcattatagataacaaagaaaattccccatataccattaattgtttactgtatatacttagatatattg taga taagaatgtgataagatcgttggtggatcaacttccatctctacctatcttcgatataaaatcatttgagaaattcata tcct actgtatacttttagatgacacattttacaatagacacgttaggaatcgcaattctaaaacgtatcgatacgcattttc aaa

-114-atacatgtcgtttgataaatacgatggtataataactaaatgtcataaagaaacaatattgctcaaactatccactgtt ct agacactacactatatgcagttttaagatgccataattcgaaaaagttaagaagatacctcaacgagttaaaaaaata taataacgataagtcctttaaaatatattctaatattatgaatgagagataccttaatgtatattataaagatatgtac gtgt caaaggtatatgataaactatttcctgttttcacagataaaaattgtctactaacattactaccttcagaaattatata cgaa atattatacatgctgacaattaacgatctttataatatatcgtatccacctaccaaagtatagttgtatttttctcatg cgatgt gtgtaaaaaaactgatattatataaatattttagtgccgtataatgaagatgacgatgaaaatgatggtacatatatat ttc gtatcattattgttattgctattccacagttacgccatagacatcgaaaatgaaatcacagaattcttcaataaaatga ga gatactctaccagctaaagactctaaatggttgaatccagcatgtatgttcggaggcacaatgaatgatatagccgctc taggagagccattcagcgcaaagtgtcctcctattgaagacagtcttttatcgcacagatataaagactatgtggttaa a tgggagaggctagaaaaaaatagacggcgacaggtttctaataaacgtgttaaacatggtgatttatggatagccaa ctatacatctaaattcagtaaccgtaggtatttgtgtaccgtaactacaaagaatggtgactgtgttcagggtatagtt ag atctcatattaaaaaacctccttcatgcattccaaaaacatatgaactaggtactcatgataagtatggcatagactta ta ctgtggaattctttacgcaaaacattataataatataacttggtataaagataataaggaaattaatatcgacgatatt aa gtattcacaaacgggaaagaaattaattattcataatccagagttagaagatagtggaagatacaactgttacgttcat t acgacgacgttagaatcaagatgtaaaatacttacggttataccgtcgcaagaccacaggtttaaactaatactagat ccaaaaatcaacgtaacgataggagaacctgccaatataacatgcactgctgtgtcaacgtcattattgattgacgat gtactgattgaatgggaaaatccatccggatggcttataggattcgattttgatgtatactctgttttaactagtagag gcg gtatcaccgaggcgaccligtactttgaaaatgttactgaagaatatataggtaatacatataaatgtcgtggacacaa ctattattttgaaaaaacccttacaactacagtagtattggagtaaatacacaatgcatlittatatacattactgaat aatt attattattatttatatcgtatttgtgctataacgcgactatctaggtatttgtatctcaccgatagagaacatataaa tgtaga ctctattaaacagttgtgtaaaatatcagatcctaatagatgtggatgtacggctttagaaatgagttcattaaaatat gtg atatcaacggaacatatttatataattatactattgctgttagtataattattgattccacggaagaactaccaacagt tact ccaattacaacaacatataattatactatcgatgatagcactactgaagaactacaagtgactcctcatatggatctcc a tcgatgatacatgtattaaaatactttccgaataagtcttttaaatattgtattaattatgaaaaactatgctatgcga gtatg atacgatactagattttatctctagcgagagatgtcgttagaatcatttatcaacgaatatcgataacatgtgtcattt atac gttaaagtctgtccgtcttctctattgtttagactgtttgtagaatgctgtgatataaacaaactagtagacacaaata tttaa ctcatgatgaagttgagaatgatatgctttagctaatataaaaatatattaatccactatatattctagacttgattta aaac cgataaactactactacgtactgtataagttaggagcagaccctaattatgtagatgatagaggtaatacttctgcatc ta tatgtccacttatgagaaaacgtcatttaataagatgcatcgtgaaaagaaatttattaaagagttggtaaaatatgaa a ccgaaagtaaataatataggaaatacacctctacataactacgtatctcaatatgatatcactctcattcctcatccac a acccattaaaaaatggaaattaaagccctctattagcataaacggctacaggtctacctttacaatggcctttccttgt gc ccagttcagaccctgtcattgccacgctactaaggactccctgaataccgtggccgacgtcagacattgtctgactgaa tacatcctgtgggtttctcatagatggacccatagagaaagcgcagggtctctctacaggcttctcatctctttcagaa ct gatgcaacggagctctttggtggtgagttgaaggattcacttccgtggagatcattaaatgactccatgaaaaccgccg

-115-aagaacttcgtgcaatcattggactttgtactcaatcagctatcgtctctggaagagtcttcaacgataagtatatcga ca tactacttatgctgcgaaagattctgaacgagaacgactatctcaccctcttggatcatatccgcactgctaaatacta a atctccttcatgctctctcactacactlittatcatcttatgaggaataattagcaccagaatagctatggattgcaca tgtatt ctatgtcgtctactggatgaagatgtgacgtacaaaaaaataaaactagaaattgaaacgtgtcacaacttatcaaaa catatagatagacgaggaaacaatgcgctacattgttacgtctccaataaatgcgatacagacattaagattgttcgac tgttactctctcgcggagtcgagagactttgtagaaacaacgaaggattaactccgctaggagcatacagtaagcata gatacgtaaaatctcagattgtgcatctactgatatccagctattcgaattcctctaacgaactcaagtcgaatataaa tg atttcgacttacgtctgctaaaatacctaattgtggataaacggatacgtccgtccaagaatacgaattatgcaatcaa t ggtctcggattggtggatatatacgtaacgacgcctaatccgagaccagaagtattgctatggcttcttaaatcagaat g ttacagcaccggttacgtatttcgtacctgtatgtacaacagtgatatgtgtaagaactctcttcattactatatatcg tctca tagagaatctctatccaaggatgtaattaaatgtttgatcgataacaatgtttccatccaatactactggtcttgctca acc atagatatagagattattaataaaggatgtggacacgtgtagagtatacgacgtcagccctatattagaggcgtattat c taaacaagcgatttagagtaaccccatataatgtagacatggaaatcgttaatcttcttattgagagacgtcatactct tgt cgacgtaatgcgtagtattacttcgtacgattccagagaatataaccactacatcatcgataacattctaaagagattt a gacaacaggatgaatccatcgtacaagccatactgataaactacttacattacggcgatatggtaagtatacctatcat tcaatgcatgliggataagacgacggacaacaactttgttaataataatctcgtcgatgtaaacgtcgtaaggtttatc gt ggaaaatatggacacgcggctgtaaatcacatatctaacaatggccgtctatgtatgtacggtctgatattatcgagat tt aataattgcgggtatcactgttatgaagatgtatttgatatactaagcaagtacatggatgatatagatatgatcgata ac tctactatattacgcggtcgatgtcaataatatacaatttgcaaagcggttattggaatatggagcgagtgtcacgctc ga taatcaatacggccatccagaaaagcagttaccaaagagaagctagttgatttattactgagttaccatcccactctag agactatgattgacgcatttaatagagatatacgctatctatatcctgaaccattattcgcctgtatcagatacgcctt aat cctagatgatgattttccttctaaagtaagtatgatatcgccggtcgtcataaggaactaaagcgctatagagcagaca t taatagaatgaagaatgcctacatatcaggcgtctccatgtttgatatattatttaaacgaagcaaacgccacagattg a gatacgcaaagaacaatgagaggatcgactccattaaataatttatcatggagtgataatgtcctgtttccatggcata t tacaaaatcgattccgtccaagatgataaaaacatttaccggcatcataaacacggagtttattttatatgtctcgcat aa acattactaaaaaaatatattgttcggttttctttcacatctttaattatgaaaaagtaaatcattatgagatggacgc atcgt tcgcgacagtatgtggtacatacctaacgtatttatggacgacggtaagaatgaaggtcacgtttctgtcaacaatgtc g acgcgatcgtgtaacacgactcacaatagaatctgtgaatgctctcccgatcatggatgcaaggcatgtgtttcccaaa caaaatgtggaataggatacggagtatccggagacgtcatctgttctccgtgtggtctcggaacatattctcacaccgt c tcttccgcagataaatgcgaacccgtacccagaaatacctttaactatatcgatgtggaaattaacctgtatccagtta a cg a ca catcg tg ta ctcg g a cg a cca cta ccg g tctca g cg a a tccatctca a cg tcg g a a cta a cta tta cta tg a at cataaagactgcgatcccgtcttcttaataaggtagcgacttcaggtttctttacaggagaaaggtgtgcactctgaat tt cgagattaaatgcaataacaaagattcttcctccaaacagttaacgaaagcaaagaatgatactatcatgccgcattc ggagacagtaactctagcgtcgacatctatatactatatagtaataccaatactcaagactacgaaactgatacaatct

-116-cttatcatgtgggtaatgtagccatatgcccggtagttgcgatatacataaactgatcactaattccaaacccacccgc tt tttatagtaagtttttcacccataaatacaataattaatttctcgtaaaagtagaaaatatattctaatttattgcacg gtaag gaagtagaatcataaagaacagtactcaatcaatagcaatcatgaaacaatatatcgtactggcatgcatgtgcctgc cagtcttcagcaatcatcctcatcgtgtacggaagaagaaaacaaacatcatatgggaatcgatgttattatcaaagtc acaaagcaagaccaaacaccgaccgatgataagatttgccaatccgtaacggaaattacagagtccgagtcagat ccagatcccgaggtggaatcagtcgaggatgtagatcctcctaccacttattactccatcatcggtggaggtctgagaa tgaactttggattcaccaaatgtcctcagattaaatccatctcagaatccgctgatggaaagactgtgaggtgtctatc g acatcagatgtagcgaagaagagaaagacagcgacatcaagacccatccagtactcgggtctaacatctctcataa gaaagtgagttacgaagatatcatcggttcaacgatcgtcgatacaaaatgtgtcaagaatctagagtttagcgttcgt atcggagacatgtgcaaggaatcatctgaacttgaggtcaagtatgtcgacggatcggcatctgaaggtgcaaccga tgatacttcactcatcgattcaacaaaactcaaagcgtgtgtctgaatcgataactctattcatctgaaattggatgag ta gggttaatcgaacgattcaggcacaccacgaattaaaaaagtgtaccggacactatattccggtttgcaaaacaaaa agttacctctcgcgacttcttctlittctgtctcaatagtgtgatacgattatgacactattcctatttcctttcaggg tatcacaa aaatattaaacctctttctgatggtctcatacaaaaatatttttattctctttctctctttgatggtctcataaaaaat atttttattct ctttctctctttgatggtctcataaaatatttttattctctttctctctttgatggtctcataaaaaatatttttattc tctttctctctttga tggtctcataaaatatttttattctctttctctctttgatggtctcataaaaaatattlitattctctttctctctttg atggtctcataaa aaatattaaacctctttctgatggtgtcactaaaatatttttattctctttctctcttcaatggagtcataaaatattt ttattctcttt ctctcttcgatggtctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctctttctctctt caatggagt cataaaatatttttattctctttctctctttgatggtctcacaaaaatatttttattctctttctctctttgatggtct cacaaaaatatt tttattctctttctctctttgatggtctcacaaaaatatttttattctctttctctctttgatggtctcataaaaaaag ttttacaaaaa tatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctclitctctctttg atggtctcataaa aaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaatattaaacctctttctgatggt gtcactaa aatatttttattctcattctctcttcaatggagtcataaaatatttttattctctttctctcttcgatggtctcacaaa aatattaaac ctctttctgatggtgtcactaaaatatttttattctcattctctcttcaatggagtcataaaatatttttattctcttt ctctcttcgatg gtctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctclicaatggagtcat aaaatat ttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatg gtctcataaaaa atattaaacctctttctgatggtgtcactaaaatatttttattctctlictctcttcaatggagtcataaaatattttt attctctttctc tcttcgatggtctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctcttcaa tggagtc ataaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctc tctttgatggtct cataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatat ttttattct ctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataa aaaatattaa acctctttctgatggtgtcactaaaatatttttattctcattctctcttcaatggagtcataaaatatttttattctct ttctctcttcga tggtctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctclicaatggagtc ataaaat atttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttga tggtctcataaa

-117-aaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttat tctctttctct ctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcacaaaaatatta aacctcttt ctgatggagtcgtaaaaaagttttatctctttctccttcgatggtctcacaaaaatattaaacctclitctgatggagt cgtaa aaaagttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagtttt atctcttt ctctcttcgatggtctcactaaaatattttttattctctttctgatgcatcaactatttcttaaacaataacgtccaac aacatat actcgtcgagcttatcaacatcccctatgcccatctaggttaccagacaattgtatatcataaaataatgtttataatt tttac aaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctct ctttgatggtct cataaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctclicaatggagtcataaa atattttt attctctttctctcttcgatggtctcacaaaaatattaaacctclitctgatggtgtcactaaaatatttttattctca ttctctcttc aatggagtcataaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttatt ctctttctctc tttgatggtctcataaaaaaaglittacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttt tacaaaa atatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctcttt gatggtctcataa aaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatattttta ttctctttct ctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaata ttaaacct ctttctgatggtgtcactaaaatatttttattctctttctctcttcaatggagtcataaaatatttttattctctttct ctcttcgatggt ctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctcttcaatggagtcataa aatatttt tattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtc tcataaaaaa agttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattct ctttctctctttg atggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttaca aaaatat ttttattctctttctctctttgatggtctcataaaaaatattaaacctctttctgatggtgtcactaaaatatttttat tctctttctctct tcaatggagtcataaaatatttttattctctttctctcttcgatggtctcacaaaaatattaaacctclitctgatggt gtcacta aaatatttttattctctttctctcttcaatggagtcataaaatatttttattctctttctctctttgatggtctcataa aaaaagttttac aaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctct ctttgatggtct cataaaaaaaglittacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatat ttttattct ctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataa aaaaagtttt acaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttct ctctttgatggt ctcataaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattttctctttctctcttcaatg gagtcataa aatatttttattctctttctctctttgatggtctcataaaaaatattaaacctclitctgatggtgtcactaaaatatt tttattctcatt ctctcttcaatggagtcataaaaaagttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctg atggag tcgtaaaaaagttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatgcatcaactattt cttaaac aataacgtccaacaacatatactcatcccctatgcccatctaggttaccagacaattgtatatcataaaataatgttta ta atttacacgttaaaatcatataataaaacgtagatcgtataatatlitttggtatataaatgatctagtaaaatccatg tagg ggatactgctcacattttttctttggtacaaaatttcacacaagtttttatacagacaaattcttgtccatatatttta aaacatt gactlitgtactaagaaaaatatctagactaactatctctttctctttctctcttcgatggtctttctgatggagtcgt aaaaaa

-118-gttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttttatct ctttctctct tcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttttatctctttctccttcgatggtct cacaa aaatattaaacctctttctgatggagtcgtaaaaaagttttatctctttctctcttcgatggtctcacaaaaatattaa acctct ttctg atg gtg tcactaaa atatttttattctctttctctcttcg atg gtctca caa aaatatta aacctctttctg atg g ag tcgt aaaaaagttttatctctttctccttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttt tatctc tttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaaglittatctctttctcctt cgatggtc tcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttttatctctttctccttcgatggtctcacaaaaat attaa a cctctttctg atggagtcg taaaaaagttttatctctttctccttcg atggtctcacaaaaatattaaacctctttctg atg ga gtcgtaaaaaagttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaa aagttt tatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttttatctcttt ctccttcg atggtctcacaaaaatattaaacctctttctgatggtctctataaagcgattgatttttcttaccctctagagtttcct acggtc gttggtcacacattthttctagacactaaataaatagtaagattaaattaattataaaattatgtatataatattaatt ataaa attatgtatatgatttactaactttagttagataaattaataatacataaattttagtatattaatattataaattaat aatacata aattttagtatattaatattatattttaaatatttatttagtgtctagaaaaaaaggccggcctagcaggcc [0075]
Alternatively, the sequence of sMVA F3 may contain 1 nucleotide alteration in a non-coding determining region at 88 bp close to the end of the ITR
sequence (deposited with NCB! under Accession No. MW030459, www.ncbi.nlm.nih.gov/nuccore/MW030459.1/) (SEQ ID NO: 15):
ggcctagcaggcctttttttctagacactaaataaatagtaagattaaattaattataaaattatgtatataatattaa ttata aaattatgtatatgatttactaactttagttagataaattaataatacataaattttagtatattaatattataaatta ataatac ataaattttagtatattaatattatattttaaatatttatttagtgtctagaaaaaaaggccggccgggtattaataat atctat atttccagcgttaagtgtaacattaaacagttttaattcacgtgacgtggtatcaattaaataattaatgcccaatttg gata tagcagcctgaagctcatcttgtttagttacggatcctaatgagttattaagcaatatatcgaacggatgaacgaaggt t gttttaagttggtcacatactttgtaatctagacatagatg cggaagaacggtag aaactatacgaaataaatattcaga gtcctctaattgatcaagagtaactattgacttaataggcatcatttatttagtattaaatgacgaccgtaccagtgac gga tatacaaaacgatttaattacagagttttcagaagataattatccatctaacaaaaattatgaaataactcttcgtcaa at gtctattctaactcacgttaacaacgtggtag atagag aacataatgccgccgtagtgtcatctccagaggaaatatcc tcacaacttaatgaagatctatttccagatgatgattctccggccactattatcgaacgagtacaacctcatactacta tta ttgacgatactccacctcctacgtttcgtagagagttattgatatcggaacaacgtcaacaacgagaaaaaagatttaa tattacagtatcgaaaaatgctg aagcaataatggaatctagatctatg atatcttctatg ccaacacaaacaccatcct tgggagtagtttatgataaagataaaagaattcagatgttggaggatgaagtggttaatcttagaaatcaacgatctaa t acaaaatcatctgataatttagataattttaccagaatactatttggtaagactccgtataaatcaacagaagttaata ag cgtatagccatcgttaattatgcaaatttgaacgggtctcccttatcagtcgaggacttggatgtttgttcagaggatg aaa

-119-tagatagaatctataaaacgattaaacaatatcacgaaagtagaaaacgaaaaattatcgtcactaacgtgattattat tgtcataaatattatcgagcaagcattgctaaaactcggatttgaagaaatcaaaggactgagtaccgatatcacttca gaaattatcgatgtggagatcggagatgactgcgatgctgtagcatcaaaactaggaatcggtaacagtccggttctt aatattgtattgtttatactcaagatattcgttaaacg aattaaaattatttaatttaatacattcccatatccag acaacaat cgtctggattaatctgttcctgtcgtctcataccggacgacatattaatctttttattagtaggcatctttttagatgg tttctttttc ccagcattaactgagtcgatacctagaagatcgtgattgatctctccgaccattccacgaacttctaattggccgtctc tg acggtaccataaactattttaccagcattagtaacagcttggacaatctgaccatccatcgcattgtacgatgtagtag t aactgttgttctacgtctaggagcaccagaagtatttttggagcccttggatgttgatgtagaagaagacgaggatttt ga ttttggtttacatgtaatacattttgtatcacatg cg ccggcagtcacatctgtttg agaattaagattattgttgcctcctttg a cggctgcatctccaccgatttgcgctagtagatttttaagctgtggtgtaatcttattaactgtttcgatataatcatc gtaact g cttctaacggctaaattttttttatccgccatttagaag ctaaaaatatttttatttatgcagaag atttaactagattataca atgaactaatatgatccttttccagattatttacaaacttggtattlittggttctggaggaggcgaatttaaattcgg acttgg atttggattttgtgggttcttgatcttattatacagcgcatataggatggcgacggtaactgctacgcaaataccgatc aac aaaagaataccaatcatttattgacaataacttcactattgatcaagtatgcaatatatcatclittcactaaataagt agt aataatgattcaacaatgtcgagatatatggacgataataatttagttcatggaaatatcgctatgattggtatgaatg ac tccgctaactctgtggggcgcgcagtgclitccccacatagaataaattagcattccgactgtgataataataccaagt a taaacgccataatactcaatactttccatgtacgagtgggactggtagacttactaaagtcaataaaggcgaagatac acgaaagaatcaaaagaatgattccagcgattagcacgccggaaaaataatttccaatcataagcatcatatccattt aactaataaaaattttaaatcgccgaatgaacaaagtggaatataaaccatataaaaacaatagtttgtactgcaaaa ataatatctatttttgttttcgaagatatggtaaaattaaatagtagtacacagcatgttataactaacagcagcaacg gct cgtaattacttatcatttactagacgaaaaggtggtgg gatattttcttgctcaaataatacgaatatatcacccatccatttt atgcgatgtttatatactctaatctttaatagatctatagacgacggglitaccaacaatatagattttatcgattcat ctaatt taaacccttccttaaacgtgaatgatctattatctggcataacgatgactctacccgatgaatcggacaatgtactggg c catgtagaataaattatcaacgaattatcgtctacgaacatttatatcatttgttttaattttagtacgcgaataaata gatat aaaatagaaaataacagatattacaaccaatgttatg gccg cgcccaaccaggtaggcagttttattttatcttttactac aggttctcctggatgtacgtcaccaacggcggacgtagttctagtacaattagacgtaagttccgcttgggaatttttt aa cgctaaagagttaacgttaatcgtgcacccaacgtatttacatctagttctttgaacatcttgattataatataaccat tttct atctctagattcgtcggtgcactcatgtaaccaacataccctaggtcctaaatatttatctccggaattagattttgga taat tcgcgcaccaacaatttctatttcctttatgatcgttacaaaagacgtataatgccgtatccccaaaagtaaaataatc ag g acgaataattctaataaactcagaacaatatctcg catccatatgtttggagcaaatatcggaataagtagacatagc cggtttccgttttgcacgtaaccattctaaacaattgggglitccaggatcgtttctacaaaatccagtcatgaaatca tca caatgttctgtcttgtaattattattaaatatttttg gacagtgtttggtatttgtcttagaacaacattttg ccacg ctatcactat cgcccaggagataatccttttttataaaatgacatcgttgcccg gatgctatataatcagtag cgtgttttaaatccttaata tattcaggagttacctcgttctgataatagattaatgatccaggacgaaatttgaaagaactacatggttctccatgaa tt

-120-aatacatattgtttagcaaattcaggaactataaaactactacaatgatctatcgacataccatctatcaaacaaaact t gggtttaatttctcccggagatgtttcataatagtacgtataactttcttctgcaaacttaacagctctattatattca ggataa ttaaaacctaattccatatatttgtctcgtatatctgctattcctggtgctattttgattctattaagagtaacggctg cccccatt tttaataatcgtcagtatttaaactgttaaatgttggtatatcaacatttaccttatttcccgcagtataaggtttgtt gcaggta tactgttcaggaatggttacatttatactttttctatagtcctgtctttcgatgttcatcacatatgcaaagaacagaa taaac aaaataatgtaagaaataatattaaatatctgtgaattcgtaaatacattgattgccataataattacagcagctacaa ta catacaatagacattcccacagtgttgccattacctccacgatacatttgagttactaagcaataggtaataactaagc t agtaagaggcaatagaaaagatgagataaatatcatcaatatagagattagaggagggctatatagagccaagac gaacaaaatcaaaccgagtaacgttctaacatcattatttttgaagattcccaaataatcattcattcctccataatcg tttt gcatcatacctccatctttaggcataaacgattgctgctgttcctctgtaaataaatctttatcaagcactccagcacc cgc agagaagtcgtcaagcatattgtaatatcttaaataactcatttatatattaaaaaatgtcactattaaagatggagta ta atctttatgccgaactaaaaaaaatgacttgtggtcaacccctaagtctttttaacgaagacggggatttcgtagaagt tg aaccgggatcatcctttaagtttctgatacctaagggattttacgcctctccttccgtaaagacgagtctagtatttga aac attaacaacgaccgataataaaattactagtatcaatccaacaaatgcg ccaaagttatatcctcttcaacg caaagtc gtatctgaagtagtttctaatatgaggaaaatgatcgaatcaaaacgtcctctatacatcactcttcacttggcgtgtg g at ttggtaagactattaccacgtgttatcttatg gctacacacggtag aaaaaccgtcatttgcgtacccaataaaatgttaa tacatcaatggaagacacaggtagaggcagtcggattggaacataagatatccatagatggagtaagtagtctatta aaggaactaaagactcaaagtccggatgtattaatagtagtcagtagacatctgacaaacgatgcctlitgtaaatata tcaataagcattatgatttgttcatcttggatgaatcacatacgtataatctgatgaacaatacagcagttacaagatt ttta gcgtattatcctccgatgatgtgttattttttaactgctacacctagaccatctaacagaatttattgtaacagtatta ttaatat tgccaagttatccgatctaaaaaaaactatctatgcagtagatagtlittttgagccatattccacagataatattaga cat atgataaaacgattagatggaccatctaataaatatcatatatataccgagaagttattatctgtagacgagcctagaa atcaacttattcttaataccctggtagaagaattcaagtcaggaactattaatcgcattttagttattactaaactacg tgaa catatggtattcttctacaaacgattattagattttttcggatcagaggligtatttataggagacgcccaaaatagac gta ctccagatatggtcaaatcaatcaaggaactaaatagatttatattcgtatccaccttattttattccggtactggttt agata ttcctagtttggattctttgttcatttgctcggcagtaatcaacaatatgcaaatagagcaattactagggagggtatg tcg agaaacagaactattagataggacggtatatgtatttcctagcacatccatcaaagaaataaagtacatgataggaa atttcgttcaacgaattattagtctgtctgtagataaactaggatttaaacaaaaaagttatcggaaacatcaagaatc c gatcccacttctgtatgtacaacatcctccagagaagaacgtgtattaaatagaatatttaactcgcaaaatcgttaag a agtttaagcgacgatccgcatgctgcgcaggccagtgtattacccctcatagtattaatataatccaatgatacttttg tg atgtcgg aaatcttaaccaatttag actgacagg cagaacacgtcatgcaatcatcatcgtcatcgataactgtagtctt gg gcttctttttg egg ctcttcattccggaacgcacattggtg ctatccatttaggtagtaaaaaataagtcagaatatg cc ctatagcacgatcgtgcaaaacctggtatatcgtctctatctttatcacaatatagtgtatcgacatctttattattat tgacct cgtttatcttggaacatggaatgggaacatttttgttatcaacggccacctttgccttaattccagatgttgtaaaatt ataac

-121-taaacagtctatcatcgacacaaatgaaattcttgtttagacgtttgtagtttacgtatgcggctcgttcgcgtctcat tlittc ag atattgcaggtactataatattaaaaataag aatgaaataacataggattaaaaataaagttatcatgacttctagc gctgatttaactaacttaaaagaattacttagtctgtacaaaagtttgaaattttcagattctgcggctatagaaaagt ata attctttggtagaatggggaacatctacttactggaaaataggcgtgcaaaaggtagctaatgtcgagacgtcaatatc tgattattatgatgaggtaaaaaataaaccgtttaatattgatccgggctattacattttcttaccggtatattttggg agcgt ctttatttattcgaagggtaaaaatatggtagaacttggatctggaaactcttttcaaataccagatgatatgcgaagt gc gtgtaacaaagtattagacagcgataacggaatagactttctgagatttgttttgttaaacaatagatggataatggaa g atgctatatcaaaatatcagtctccagttaatatatttaaactagctagtgagtacggattaaacatacccaaatattt ag aaattgaaatagaggaagacacattatttgacgacgagttatactctattatagaacgctctttcgatgataaatttcc aa aaatatccatatcgtatattaagttgggagaacttaggcggcaagttgtagactttttcaaattctcattcatgtatat tgagt ccatcaaggtagatcgtataggagataatatttttattcctagcgttataacaaaatcaggaaaaaagatattagtaaa a gatgtagaccatttaatacgatccaaggttagagaacatacatttgtaaaagtaaaaaagaaaaacacattttccattt t atacgactatgatggaaacggaacagaaactagaggagaagtaataaaacgaattatagacactataggacgag actattatgttaacggaaagtatttctctaaggttggtagtgcaggcttaaagcaattgactaataaattagatattaa tga gtgcgcaactgtcgatgagttagttgatgagattaataaatccggaactgtaaaacgaaaaataaaaaaccaatcag catttgatttaagcagagaatgtttgggatatccagaagcggattttataacgttagttaataacatgcggttcaaaat ag aaaattgtaaggttgtaaatttcaatattgaaaatactaattgtttaaataacccgagtattgagactatatatggaaa cttt aaccagttcgtctcaatctttaatatcgtcaccgatgtcaaaaaaagattattcgagtgaaataatatgcgcctttgat ata ggtgcaaaaaatcctgccagaactgttttagaagtcaaggataactccgttagggtattggatatatcaaaattagact ggagttctgattgggaaaggcacatagctaaagatttgtcacaatatgaatacactacagttcttctagaacgtcagcc t agaaggtcgccgtacgtcaaatttatctattttattaaaggctttttatatcatacatcggctgccaaagttatttgcg tctcg cctgtcatgtctggtaattcatatagagatcgaaaaaagagatcggtcgaagcatttcttgattggatggacacattcg g attgcgagactccgttccggatagacgcaaattagacgatgtagcggatagtttcaatttggctatgagatacgtatta g ataaatggaatactaattatacaccttataataggtgtaaatctagaaattacataaaaaaaatgtaataacgttagta a cgccattatggataatctatttacctttctacatgaaatagaagatag atatg ccag aactatttttaactttcatctaataag ttgcgatgaaataggagatatatatggtcttatgaaagaacgcatttcctcagaggatatgtttgataatatagtgtat aat aaagatatacatcatgccattaagaaactagtgtattgcgacatccaacttactaaacacattattaatcagaatacgt a tccggtatttaacgattcttcacaagtgaaatgttgtcattatttcgatataaactcagataatagcaatattagctct cgtac agtagagatatttgagagggaaaagtcatctcttgtatcatatattaaaactaccaataagaagagaaaggtcaattat ggggaaataaagaaaactgtacatggaggcactaatgcaaattacttttccggtaaaaagtctgatgagtatctgagc actacagtcaggtccaacattaatcaaccttggatcaaaaccatttctaagagaatgagagtagatatcattaatcact ctatagtaacgcgtggaaaaagctctatattacaaactatagaaattatttttactaatagaacatgtgtgaaaatatt ca aggattctactatgcacattattctatccaaggacaaggatgaaaaggggtgtatacacatgattgacaaattattcta t gtctattataatttatttctgttgttcgaggatatcatccaaaacgagtactttaaagaagtagctaatgttgtaaacc acgt

-122-actcacggctacggcattagatgagaaattattcctaattaagaaaatggctgaacacgatglitatggagttagcaat t tcaaaatagggatgtttaacctgacatttattaagtcgttggatcataccgttttcccctctctgttagatgaggatag caaa ataaagtlitttaaggggaaaaagctcaatattgtagcattacgatctctggaggattgtataaattacgtgactaaat cc gagaatatgatagaaatgatgaaggaaagatcgactattttaaatagcatagatatagaaacggaatcggtagatcg tctaaaagaattgcttctaaaatgaaaaaaaaacactaattcagaaatggatcaacgactcggatataagtttttggtg cctgatcctaaagccggagttttttatagaccgttacatttccaatatgtatcgtattctaattttatattgcatcgat tgcatga aatcttgaccgtcaagcggccactcttatcgtttaagaataatacagaacgaattatgatagaaattagcaatgttaaa gtgactcctccagattactcacctataatcg cgagtattaaaggtaagagttatgacgcattagccacgttcactgtaaa tatctttaaagaggtaatgaccaaagagggtatatccatcactaaaataagtagttatgagggaaaagattctcatttg a taaaaattccgctactaataggatacgggaataaaaatccacttgatacagccaagtatcttgttcctaatgtcatagg t ggagtctttatcaataaacaatctgtcgaaaaagtaggaattaatctagtagaaaagattacaacatggccaaaattta g g g ttg tta a g cca a a ctca ttca ctttctcg ttttcctccg tatcccctccta a tg tatta ccg a ca a g atatcg cca tta ca agatatctctggatatatcacaattggaagcgttgaatatatcatcgacaaagacatttataacggtcaatattgtttt gct gtctcaatatttatctagagtgagtctagaattcattagacgtagtttatcatacgatatgcctccagaagttgtctat ctagt aaacgcgataatagatagtgctaaacgaattactgaatctattactgactttaatattgatacatacattaatgacctg gt ggaagctgaacacattaaacaaaaatctcagttaacgatcaacgagttcaaatatgaaatgctgcataactttttacct catatgaactatacacccgatcaactaaagggattttatatgatatctttactaagaaagtttctctactgtatctacc aca cttctagatatccagatagagattcgatggtttgtcatcgcatcctaacgtacggcaaatattttgagacgttggcaca tg atgaattagagaattacataggcaacatccgaaacgatatcatgaacaatcacaagaacagaggcacttacgcggt aaacattcatgtactaacaactcctggacttaatcatgcattttctagtctattgagtggaaagttcaaaaagtcagac gg tagttatcgaacacatcctcactattcatg gatg cagaatatttctattcctaggagtgttggattttatccggatcaagtaa agatttcaaagatgttttctgtcagaaaataccatccaagtcaatatctttacttttgttcatcggacgttccggaaag aggt cctcaggtaggtttagtatctcaattgtctgtcttgagttccattacaaatatactaacgtctgagtatttggatttgg aaaag aaaatttgtgagtatatcagatcatattataaagatgatataagttactttgaaacaggatttccaatcactatagaaa at gctctagtcgcatctcttaatccaaatatgatatgtgattttgtaactgactttagacgtagaaaacggatgggattct tcgg taacttggaggtaggtattactttagttagggatcacatgaatgaaattcgcattaatattggagcgggaagattagtc a gaccattcttggttgtggataacggagagctcatgatggatgtgtgtccggagttagaaagcagattagacgacatga cattctctgacattcagaaagagtttccgcatgtcatcgaaatggtagatatagaacaatttacttttagtaacgtatg tga atcggttcaaaaatttagaatgatgtcaaaggatgaaagaaagcaatacgatttatgtgactttcctgccgaatttaga g atggatatgtagcatcttcactagtgggaatcaatcacaattctggacccagagctattcttggatgtgctcaagctaa a caagctatctcttgtctgagctcggatatacgaaataaaatagacaatggaattcatttgatgtatccagagaggccaa t cgtgattagtaaggctttagaaacttcaaagattgcggctaattgcttcggccaacatgttactatagcattaatgtcg tac aaaggtatcaatcaagaggatggaattatcatcaaaaaacaatttattcagagaggcggtctcgatattgttacagcc aagaaacatcaagtagaaattccgttggaaaactttaataacaaagaaagagataggtctaacgcctattcaaaatt

-123-agaaagtaatggattagttagactgaatgctttcttggaatccggagacgctatagcacgaaatatctcatcaagaact cttgaagatgattttgctagagataatcagattagctttg atgtttccgaaaaatataccgatatgtacaaatctcgcgttg aacgagtacaagtagaacttactgacaaagttaaggtacgagtattaaccatgaaagaaagaagacccattctagg agacaaatttaccactagaacgagtcaaaagggaacagtcgcgtatatcgcggatgaaacggaacttccatacgat gaaaatggtatcacaccagatgtcattattaattctacatccatcttctctagaaaaactatatctatgttgatagagg ttatt ttaacagccgcatattctg ctaagccgtacaacaataagg gagaaaaccgacctgtctgttttcctagtagtaacgaa acatccatcgatacatatatgcaattcgctaaacaatgttatgagcattcaaatccgaaattgtctgatgaagaattat cg gataaaatcttttgtgaaaagattctctatgatcctgaaacggataagccttatgcatccaaagtattttttggaccaa ttta ttacttgcgtctgaggcatttaactcaggacaaggcaaccgttagatgtagaggtaaaaagacgaagctcattagaca ggcgaatgagggacgaaaacgtggaggaggtatcaagttcggagaaatggagagagactgtttaatagcgcatg gtgcagccaatactattacagaagttttgaaagattcggaagaagattatcaagatgtgtatgtttgtgaaaattgtgg a gacatagcag cacaaatcaag ggtattaatacatgtcttag atgttcaaaacttaatctctctcctctcttaacaaaaatt g ataccacgcacgtatctaaagtatttcttactcaaatgaacgccagag gcgtaaaagttaaattagatttcgaacgaa ggcctccttcgttttataaaccattagataaagttgatctcaaaccgtcttlictggtgtaatattctagtttggtagt agatac atatcaatatcatcaaattcgagatccgaattataaaatgggcgtggattgttaactatagaatcggacgtctgatatt cg aaaatctgtggagttttaggttttggtggaggtgtaactgctacttgggatactgaagtctgatattcagaaagctggg gg atgttctggttcgacatccaccgatggtgtcacatcactaatcggttcg gtaacgtctgtggacgatggagg caccactt ctacaggttctgglictttatcctcagtcatcaacggagctacttcaatgcgaggaaatgtataatttggtaatggttt ctcat gtggatctgaag aagaggtaagatatctactagaaag ataccgatcacgttctagttctcttttgtagaacttaactttttct ttctccgcatctagttgatattccaacctcttcacgttcgcatgggttacctccgcagtttttacgagcgatttcacgt tcagc cttcatgcgtcttatagcatgaattcgcttatcgttatcgggtttagcttctgtcaccttagcaattccttlittatta aactctaca taatcatatccatttctattgtttgttctaatataaacgagtatagcatcattgctaaatttttcaatagtatcgaaaa cagaat atcctaaaccatataatatatattcaggaacactcaaactaaatgtccaggattctcctaaatacgtaaactttaatag tg cgaaatcattcaaaaatctaccacttatagatag atagatagtacataaatgcgtatagtagtctacctatctctttattatg aaaaccggcattacgatcatatatgtcgtgatatacctgtgatccgtttacgttaaaccataaatacatgggtgatcct at aaacatgaatttatttctaattctcagag ctatagttaattgaccgtgtaatatttgcttacatgcatacttg atacgatcatta ataagatlittatcattgctcgttatttcagaatcgtatatataaggagtaccatcgtgattcttaccagatattatac aaaat actatatataaaatatattgacccacgttagtaatcatgtaaatgtttaacgttttaaattttgtattcaatgatccat tatcata cgctagcatggtcttatgatattcattctttaaaatataatattgtgttagccattgcattggggctcctaatggagat tttttatt ctcatccattttaggataggctttcataaagtccctaataacttcgtgaataatgtttctatgttttctactgatgcat gtatttgc ttcgatttttttatcccatgtttcatctatcatagatttaaacgcagtaatgctcgcaacattaacatcttgaaccgtt ggtaca attccgttccataaatttataatgttcgccatttatataactcattttttgaatatacttttaattaacaaaagagtta agttactc atatggacgccgtccagtctgaacatcaatctttttagccagagatatcatagccgctcttagagtttcagcgtgattt tcc aacctaaatagaacttcatcgttgcgtttacaacactlitctatttgttcaaactttgttgttacattagtaatctttt tttccaaatt

-124-agttagccgttgtttgagagtttcctcattgtcgtcttcatcggctttaacaattgcttcgcgtttagcctctggcttt ttagcagc cgttgtagaaaaaaattcagttgctggaattgcaagatcgtcatctccggggaaaagagttccgtccatttaaagtaca g attttagaaactgacactctgcgttatttatatttggtacaacacatg gattataaatattgatgttaataacatcagaaaa tgtaaagtctatacattgttgcatcgtgttaaattlictaatggatctagtattattgggtccaacttctgcctgaaat ccaaat atggaag cggatacaaaaccgtttcctgg ataaaccacacatctccacttttgctttacatcagaaattgtgtcgttg aca tcttgaactctcctatctaatgccggtgttccacctatagattttgaatattcgaatgctgcatgagtagcattaaatt cctta atattgccataattttcatatattgagtaaccctg gataaaaagtaaacacaccgcagccgtagctaccacaataaaa aaaattgatagagagttcatttataatctattagaagctgacaaaatttttttacacgcatcagacaatgctttaataa ata gttcaacatctacttttgtcatatcgaaccgatggtatgattctaacctagaattacatccgaaaaagttgactatgtt cata gtcattaagtcattaacaaacaacattccagactctggattataagacgatactgtttcgtcacaattacctaccttaa tca tgtgattatgaatattggctattagagcaccttctaagaaatctataatatctttgaaacacgatttaaaatcaaacca cg aatatacttctacgaagaaagttagtttacccataggagaaataactataaatggagatctaaatacaaaatccggat ctatgatagttttaacattattatattctctattaaatacctccacatctaaaaatgttaattttgaaactatgtcttc gtttattac cgtacctgaactaaacgctataagctctattgtttgagaactclitaaacgatattcttgaaatacatgtaacaaagtt tcct ttaactcggtcgglitatctaccatagttacagaatttgtatccttatctataatataataatcaaaatcgtataaagt tatata attatcgcgttcagattgggatclittcaaatagactaaaaaccccatttctctagtaagtatcttatgtatatgtttg taaaat atcttcatggtgggaatatgctctaccgcagttagccattcctcattgacagcggtagatgtattagacaaaactattc ca atgtttaacaagggccattttacgagattattaaatccttgtttgataaatgtagccaatgagggttcgagttcaacga cg attgaattctcttcccg egg atgctgcatgatgaacgacgggatgttgttcg attgatttgg aattctttttcgactttttgtttat attaaatattttaaaatttatagcggatagcaattcatgtaccacggataatgtagacgcgtattgcgcatcgatatct ttat tattagataaatttatcaataaatgtgagaagtttgcctcgttaaggtcttccatttaaatattatataaacatttgtg tttgtatc ttattcgtcttttatggaatagttttttactagtaaagctgcaattacacactttgtccgtaaaacataaatataaaca ccagc ttttatcaatcgttccaaaaagtcgacggcggacatttttaacatggcatctattttaaatacacttaggttlitggaa aaaa catcattttataattgtaacgattcaataactaaagaaaagattaagattaaacataagggaatgtcatttgtatttta taa g ccaaagcattctaccgttgttaaatacttgtctg gag gaggtatatatcatgatg atttggttgtattggg gaaggtaaca attaatgatctaaagatgatgctattttacatggatttatcatatcatggagtgacaagtagtggaacaatttacaaat tgg gatcgtctatcgatagactttctctaaataggactattgttacaaaagttaataattataattatgatacatttlitga cgatga tgattgatcgctattgcacaattttgtttttttactttctaatatagcgtttagattctttttcatgtgcgaatattga tttactaaaat atctatgtttaacttttgttctataacgtccttatcgg cggtatcggtacatatacgtaattcaccttcacaaaatacggagtc ttcgataataatagccaatcgattattggatctagctgtctgtatcatattcaacatgtttaatatatcctttcgtttc ccctttac ag gcatcgatcgtagcatattttccg cgtctgag atggaaatgttaaaactacaaaaatgcgtaatgttagcccgtccta atattggtacgtgtctataagtttggcatagtagaataatagacgtgtttaaatgccttccaaagtttaagaattctat taga gtattgcattttgatagtttatcgcctacatcatcaaaaataagtaaaaagtgtgctgattttttatgattttgtgcga cagca atacattlitctatgttacttttagttcgtatcagattatattctagagattcctgactactaacgaaattaatatgat ttggcca

-125-aatgtatccatcataatctg gattataaacgg gtgtaaacaag aatacatgtttatattttttaactagtgtagaaaacaga gatagtaaatagatagtlittccagatccagatcctcccgttaaaaccattctaaacggcatttttaataaattttctc ttgaa aattgtttttcttggaaacaattcataattatatttacagttactaaattaatttgataataaatcaaaatatggaaaa ctaag gtcgttagtagggaggagaacaaagaaggcacatcgtgacataaataacatttattatcatgatgacaccagaaaa cgacgaagagcagacatctgtgttctccgctactglitacagagacaaaattcagggaaagaataaacgcaaacgc gtgattggtctatgtattagaatatctatggttatttcactactatctatgattaccatgtccgcgtttctcatagtgc gcctaaa tcaatgcatgtctgctaacgaggctgctattactgacgccgctgttgccgttgctgctgcatcatctactcatagaaag gtt g cgtctagcactacgcaatatg atcacaaagaaagctgtaatg gtttatattaccagggttcttgttatatattacattcag a cta cca g ttattctcg g a tg cta a ag ca a a ttg ca ctg cg g a atcatca a ca cta ccca ata a atccg a tg tcttg a ct acctggctcattgattatgttaaggatacatggggatctgatggtaatccaattacaaaaactacatccgattatcaag at tctgatgtatcacaagaagttagaaagtatttttgtgttaaaacaatgaactaatatttatttttgtacattaataaat gaaat cgcttaatagacaaactgtaagtaggtttaagaagttgtcg gtgccggtcgctataatg atgatactctcaaccattatta gtggcataggaacatttctgcattacaaagaagaactgatgcctagtgcttgcgccaatggatggatacaatacgata aacattgttatttagatactaacattaaaatgtctacagataatgcggtttatcagtgtcgtaaattacgagccagatt gcc tagaccggatactagacatctgagagtattglitagtattttttataaagattattgggtaagtttaaaaaagaccaat gat aaatggttagatattaataatgataaagatatagatattagtaaattaacaaattttaaacaactaaacagtacgacgg atgctgaagcgtgttatatatacaagtctggaaaactggttaaaacagtatgtaaaagtactcaatctgtactatgtgt ta aaaaattctacaagtgacaacaaaaaatgaattaataataagtcgttaacgtacgccgccatggacgccgcgtttgtt attactccaatgggtgtgttgactataacagatacattgtatgatgatctcgatatctcaatcatggactttataggac cata cattataggtaacataaaaactgtccaaatagatgtacgggatataaaatattccgacatgcaaaaatgctactttagc tataagggtaaaatagttcctcaggattctaatgatttggctagattcaacatttatagcatttgtgccgcatacagat caa aaaataccatcatcatag catgcgactatgatatcatgttagatatagaagataaacatcag ccattttatctattcccat ctattgatgtttttaacgctacaatcatagaagcgtataacctgtatacagctggagattatcatctaatcatcaatcc ttca gataatctgaaaatgaaattgtcgtttaattcttcattctgcatatcagacggcaatggatggatcataattgatggga aat gcaatagtaattttttatcataaaagttgtaaagtaaataataaaacaataaatattgaactagtagtacgtatattga gc aatcagaaatgatgctg gtacctcttatcacggtgaccgtagttg cgggaacaatattagtatgttatatattatatatttgt aggaaaaagatacgtactgtctataatgacaataaaattatcatgacaaaattaaaaaagataaagagttctaattcc agcaaatctagtaaatcaactgatagcgaatcagactgggaggatcactgtagtgctatggaacaaaacaatgacg tagataatatttctaggaatgagatattggacgatgatagcttcg ctggtagtttaatatgggataacgaatccaatgttat ggcgcctagcacagaacacatttacgatagtgttgctggaagcacgctgctaataaataatgatcgtaatgaacaga ctatttatcagaacactacagtagtacttaatg aagataccaaacagaatcctaactattcatccaatcctttcgtaaatt ataataaaaccagtatttgtagcaagtcaaatccgttcattacagaactcaacaataaatttagtgagaataatccgtt t agacgagcacatagcgatgattatcttaataagcaagaacaagatcatgaacacgatgatatagaatcattggtgtg attagtttcctttttataaaattgaagtaatatttagtattattgctgccgtcacgttgtacaaatggagatattccct gtattcg

-126-g catttctaaaattagcaattttattgctaataatg actgtagatattatatagatacagaacatcaaaaaattatatctgat gagatcaatagacagatggatgaaacggtacttcttaccaacatcttaagcgtagaagttgtaaatgacaatgagatg taccatcttattcctcatagattatcgacgattatactctgtattagttctgtcggaggatgtgttatctctatagata atgacgt caatgg caaaaatattctaacctttcccattg atcatgctgtaatcatatccccactgagtaaatgtgtcgtagttagcaa gggtcctacaaccatattggttgttaaagcggatatacctagcaaacgattggtaacatcgtttacaaacgacatactg t atgtaaacaatctatcactgattaattattcgccgttgtctgtattcattattagacgagttaccgactatttggatag acaca tatgcgatcagatatttgcgaataataagtggtattccattataaccatcgacaataagcagtttcctattccatcaaa ctg tataggtatgtcctctgccaagtacataaattctagcatcgag caagatactttaatacatgtttgtaacctcgag catcc attcgacttagtatacaaaaaaatgcagtcgtacaattctgtacctatcaaggaacaaatattgtacggtagaattgat a atataaatatgag cattagtatttctgtggattaatagatttctagtatgggg atcattaatcatctctaatctctaaatacctc ataaaacgaaaaaaaagctattatcaaatactgtacggaatggattcattctcttctctttttatgaaactctgttgta tatct actgataaaactggaagcaaaaaatctgataaaaagaataagaataagatcaaggattattataaaataacaatag ttcctggttcctcttccacgtctactagctcgtggtattatacacatgcctagtaatagtctctttgcgttgacggaaa gcag actagaaataacaggctaaaatgttcagacaccataatagttcccaacccagataataacagagtaccatcaacac attcctttaaactcaatcccaaacccaaaaccgttaaaatgtatccggccaattgatagtagataatgaggtgtacagc gcatgatgatttacacagtaaccaaaatgaaaatactttagtaattataagaaatatagatggtaacgtcatcatcaac aatccaataatatgccggagagtaaacattgacggataaaacaaaaatgctccgcataactctatcatggcaataac acaaccaaatacttgtaagattcctaaattagtag aaaatacaacggatatcgatgtataagtg atctcgagaaataat aagaataaagtaatgcccgtaaagataaacatcaacattgtttggtaatcattaaaccaattagtatgaagttgaacta atttcacagtagattttattccagtattatccccgcatgtataagtacctggtaagatatctttatattccataatcaa tgaga catcactatctg ataacgaatgaagtctagcactagtatg ccatttacttaatattgtcgtcttggaagttttattataagtta aaatatcatggttatccaatttccatctaatatactttgtcg gattatctatagtacacggaataatgatggtatcattacatg ctgtatactctatggtctttgtagttgttataacaaccaacgtatagaggtatatcaacgatattctaactcttgacat tttttatt tatttaaaatgatacctligttatttattttattctattttgctaacggtattgaatggcataagtttgaaacgagtga agaaata atttctacttacttattagacgacgtattatacacgggtgttaatggggcggtatacacattttcaaataataaactaa aca aaactggtttaactaataataattatataacaacatctataaaagtagaggatgcggaaccaataacggaaatccca aatgttggaaaatagacggttcagacgacccaaaacatagaggtagaggatacgctccttatcaaaatagcaaagt aacgataatcagtcacaacggatgtgtactatctgacataaacatatcaaaagaaggaattaaacgatggagaaga tttgacggaccatgtggttatgatttatacacggcggataacgtaattccaaaagatgglitacgaggagcattcgtcg a taaagatggtacttatgacaaagtttacattcttttcactgatactatcggctcaaagagaattgtcaaaattccgtat ata gcacaaatgtgcctaaacgacgaaggtggtccatcatcattgtctagtcatagatggtcgacgtttctcaaagtcgaat t agaatgtgatatcgacggaagaagttatagacaaattattcattctagaactataaaaacagataatgatacgatacta tatgtattcttcgatagtccttattccaagtccgcattatgtacctattctatgaataccattaaacaatcttlitcta cgtcaaa attggaaggatatacaaagcaattgccgtctccagctcctggtatatgtttaccagctggaaaagttgttccacatacc a

-127-cgtttgaagtcatagaaaaatataatgtactagatgatattataaagcctttatctaaccaacctatcttcgaaggacc gt ctggtgttaaatggttcgatataaaggagaaggaaaatgaacatcgggaatatagaatatacttcataaaagaaaatt ctatatattcgttcgatacaaaatctaaacaaactcgtag ctcgcaagtcg atgcg cgactattttcagtaatggtaactt cgaaaccgttatttatagcagatatagggataggagtaggaatgccacaaatgaaaaaaatacttaaaatgtaatctt aatcgagtacaccgcacgacaatgaacaaacataagacag attatgctggttatg cttgctgcgtaatatg cggtcta attgttggaattattlitacagcgacactattaaaagttgtagaacgtaaattagttcatacaccatcaatagataaaa cg ataaaagatgcatatattagagaagattgtcctactgactggataagctataataataaatgtatccatttatctactg atc gaaaaacctgggaggaaggacgtaatgcatgcaaagctctaaatccaaattcggatctaattaagatagagactcc aaacgagttaagttttttaagaagcattagacgcggatattgggtaggagaatccgaaatattaaaccagacaaccc catataattttatagctaaaaatgccacgaagaatggaactaaaaaacggaaatatatttgtagtacaacgaatactc ccaaactacatttttatcataccactacttcggttagatgttttagaaaaaaataaatatcgccgtaccgttcttgttt ttataa aaataacaattaacaattatcaaattttttctttaatattttacgtggttgaccattcttggtggtaaaataatctctt agtgligg aatggaatgctgtttaatglitccgcactcatcgtatattttgacgtatgcagtcacatcgtttacgcaatagtcagac tgta gttctatcatgcttcctacatcagaaggaggaacagttttaaagtctcttggttttaatctattgccattagttttcat gaaatc ctttgttttatccacttcacattttaaataaatgtccactatacattcttctgttaattttactagatcgtcatgggtc atagaattt ataggttccgtagtccatggatccaaactagcaaacttcgcgtatacggtatcgcgattagtgtatacaccaactgtat g aaaattaagaaaacagtttaataaatcaacagaaatatttaatcctccgtttgatacagatgcgccatatttatggatt tc ggattcacacgttgtttgtctgaggtgttcgtctagtgttgcttctacgtaaacttcgattcccatatattctttattg tcagaatc gcataccgatttatcatcatacactgtttgaaaactaaatggtatacacatcaaaataataaataataacgagtacatt ct gcaatattgttatcgtaattggaaaaatagtgttcgagtgagttggattatgtgagtattggattgtatattttatttt atattttat attttgtagtaagaatagaatgctaatgtcaagtttattccaatagatgtcttattaaaaaacatatataataaataac aat ggctgaatggcataaaattatcgaggatatctcaaaaaataataagttcgaggatgccgccatcgttgattacaagac tacaaagaatgttctagctgctattcctaacagaacatttg ccaag attaatcctctcatcactaatcgtaatattctaaaa cctcttattggtcagaaatattgtattgtatatactaactctctaatggatgagaacacgtatgctatggagttgctta ctgg gtacg cccctgtatctccgatcgttatag cgagaactcataccgcacttatatttttg atgggtaagccaacaacatcca gacgtgacgtgtatagaacgtgtagagatcacgctacccgtgtacgtgcaactggtaattaaaataaaaagtaatatt catatgtagtgtcaattttaaatgatgatgatgaaatggataatatccatattgacgatgtcaataatg ccg gtattgg cat acagttcatcgatttttagatttcattcagaggatgtggaattatgttatgggcatttgtattttgataggatctataa tgtagta aatataaaatataatccg catattccatatagatataattttattaatcgcacgttaaccgtagatg aactagacgataat gtcttttttacacatggttattttttaaaacacaaatatgglicacttaatcctagtttgattgtctcattatcaggaa acttaaa atataatgatatacaatgctcagtaaatgtatcgtgtctcattaaaaatttggcaacgagtacatctactatattaaca tct aaacataagacttattctctacatcggtccacgtgtattactataataggatacgattctattatatggtataaagata taa atgacatctatgattttactgcaatatgtatgctaatagcgtctacattgatagtgaccatatacgtgtttaaaaaaat aaa aatgaactcttaattatgctatgctattagaaatggataaaatcaaaattacggttgattcaaaaattggtaatgttgt tacc

-128-atatcgtataacttggaaaagataactattgatgtcacacctaaaaagaaaaaagaaaaggatgtattattagcgcaa tcagttgctgtcgaagaggcaaaagatgtcaaggtagaagaaaaaaatattatcgatattgaagatgacgatgatat ggatgtagaaagcgcataatacgatctataaaaataagtatataaatactttttatttactgtactcttactgtgtagt ggtg ataccctactcgattattthttaaaaaaaaatacttattctgattcttctagccatttccgtgttcgttcgaatgccac atcgac gttaaagataggggagtagttgaaatctagttctgcattgttggtacgcacctcaaatgtagtgttggatatclicaac gta tagttgttgagtagtgatggttttctaaatagaattctcttcatatcattcttgcacgcgtacatttttagcatccatc ttggaatc ctagatccttgttctattcccaatgglitcatcaatagaagattaaacatatcgtacgaacacgatggagagtaatcgt ag caaaagtaagcatttcctttaatctcagatcccggatactggatatattttgcagccaacacgtgcatccatgcagcat tt cctacatatacccggctatgtaccgcgttatcatcgactgtacgatacataatgttaccgtgttgcttacattgctcgt aaa agactttcatcaatttgtctccttctccgtaaattccagtgg gtcttaggcaacaagtatacaattttgctccattcatg attac ggaattattggctttcataaccagttgctcggccatacgtttactttttgcgtatacatgtcctggtgatatatcataa agggt atgctcatggccgatgaatggatcaccgtgtttattgggtcctattgcttccatgctactagtatagatcaaatacttg attc ctaggtccacacaagctgccaatatagtctgtgttccataatagtttactttcatgatttcattatcggtgtattttcc aaatac atccactagagcagctgtatgaataatcagatttaccccatctag cgcttctcttaccttatcaaagtcgtttatatcacatt gtatatagtttataaccttaactttcgaggttattggttgtggatcttctacaatatctatgactctgatttcttgaac atcatctg cactaattaacagttttactatatacctgcctagaaatccg gcaccaccagtaaccg cgtacacggccattgctgccac tcataatatcagactacttattctattttactaaataatggctgtttgtataatagaccacgataatatcagaggagtt attta ctttgaaccagtccatggaaaagataaagttattggattaaaatccggaacgtatagtttgataattcatcgttacgga g atattagtcaagg atgtgattccatagg cagtccagaaatatttatcggtaacatctttgtaaacagatatggtgtag cat atgtttatttagatacagatgtaaatatatctacaattattggaaagg cgttatctatttcaaaaaatgatcagagattagc gtgtggagttattggtatttcttacataaatgaaaagataatacattttcttacaattaacgagaatggcgtttgatat atca gttaatgcgtctaaaacaataaatgcattagtttacttttctactcagcaaaataaattagtcatacgtaatgaagtta atg atacacactacactgtcgaatttgatagggacaaagtagttgacacgtttatttcatataatagacataatgactccat ag agataagaggggtgcttccagaggaaactaatattggttgcgcggttaatacgccggttagtatgacttacttgtataa t aagtatagttttaaactgattttagcagaatatataagacacagaaatactatatccggcaatatttattcggcattga tga cactagatgatttggctattaaacagtatggagacattgatctattatttaatgagaaacttaaagtagactccgattc gg gactatttgactttgtcaactttgtaaaggatatgatatgttgtgattctagaatagtagtagctctatctagtctagt atctaa acattgggaattgacaaataaaaaatataggtgtatggcattagccgaacatatatctgatagtattccaatatctgag c tatctagactacgatacaatctatgtaagtatctacgcgg gcacactgag agcatagaggatg aatttgattattttgaa gacgatgattcgtctacatgttctgccgtaaccgacagggaaacggatgtataattttlittatagcgtgaaggatatg at aaaaaatataattgttgtatttatcccattccaatcaccttatatgattctgtaacacaatgaaggagtcttatagatg tata gaggtcagatactggtttgataaactglitattccacataagtatgtttgactttatggttagacccgcatactttaac aaatc actgaaaattggagttaggtattgacctctcagaatcagttgccgttctggaacattaaatgtattttttatgatatac tcca acgcatttatgtgggcatacaacaagtcattactaatggagtattccaagagaagagatttcaacagactgtttatgaa

-129-ctcgaatgccgcctcattgtcgcttatattgatgatgtcgaattctcccaatatcatcaccgatgagtagctcatcttg ttatc gggatccaagttttctaaagatgtcattaaaccctcgatcatgaatggatttatcatcatcgtttttatgttggacatg agctt agtccgtttgtccacatctatagacgacgatttctgaattatttcatatatccctctclitaactccaggaacttgtca ggatg gtctactttaatatglictcgtctaagagatgaaaatctttggatggttgcacgcgacttttctctaaaggatcctctc ttaaat gaatccatcttatccttggacaagatggacagtctattttccttagatggtttaatatttttgttacccatgatctata aaggta g acctaatcgtctcg gatgaccatatatttattttcagttttattatacg cataaattgtaaaaaatatgttaggtttacaaaa atgtctcgtg gggcattaatcgtttttgaaggattggacaaatctg gaaaaacaacacaatgtatgaacatcatggaat ctataccggcaaacacgataaaatatcttaactttcctcagag atccactgtcactggaaagatgatag atgactatct aactcgtaaaaaaacctataatgatcatatagttaatctattattligtgcaaatagatgggagtttgcatcttttata caag aacaactagaacagggaattactttaatagttgatagatacgcattctctggagtagcgtatgccgccgctaaaggcg cgtcaatgactctcagtaagagttatgaatctggattg cctaaacccgacttagttatattcttg gaatctggtagcaaag aaattaatagaaacgtcggcgaggaaatttatgaagatgttacattccaacaaaaggtattacaagaatataaaaaa atgattgaagaaggagatattcattggcaaattatttcttctgaattcgaggaagatgtaaagaaggagttgattaaga a tatagttatagaggctatacacacggttactggaccagtggg gcaactgtgg atgtaatagtgaaattacattttttataa atggatgaagcatattactctggcaacttggaatcagtactcggatacgtgtccgatatgcataccgaactcgcatcaa tatctcaattagttattgccaagatagaaactatagataatgatatattaaacaaggacattgtaaattttatcatgtg tag atcaaacttg gataatccatttatctctttcctagatactgtatatactattatagatcaagagatctatcagaccgaattg at taattcattagacgacaatgaaattatcgattgtatagttaacaagtttatgagcttttataaggataacctagaaaat ata gtagatgctatcattactctaaaatatataatgaataatccagattttaaaactacgtatgccgaagtactcggttcca ga atagcg gatatagatattaaacaagtg atacgtg agaatatactacaattgtctaataatatccgcgaacgatatttgtg aaaatattaaaaaaaaatacttlitttattaaatgacgtcgcttcgcgaatttagaaaattatgctgtgatatatatca cgca tcag gatataaagaaaaatctaaattaattagagactttataacagatag ggatgataaatatttgatcattaagctattg cttcccggattagacgatagaatttataacatgaacgataaacaaattataaaattatatagtataatatttaaacaat ct caggaagatatgctacaagatttaggatacggatatataggagacactattaggactlicttcaaagagaacacaga aatccgtccacgagataaaagcattttaactttagaag aagtggatagttttttaactacgttatcatccgtaactaaaga atcgcatcaaataaaattattgactgatatcgcatccgtttgtacatgtaatgatttaaaatgtgtagtcatgcttatt gataa ag atctaaaaattaaagcgggccctcggtacgtacttaacg ctattagtcctcatgcctatgatgtgtttag aaaatctaa taacttgaaagagataatagaaaatgcatctaaacaaaatctagactctatatctatttctgttatgactccaattaat ccc atgttagcggaatcgtgtgattctgtcaataaggcgtttaaaaaatttccatcaggaatgtttgcggaagtcaaatacg at ggtgaaagagtacaagttcataaaaataataacgagtttgccttctttagtagaaacatgaaaccagtactctctcata aagtggattatctcaaagaatacataccgaaagcatttaaaaaagctacgtctatcgtattggattctgaaattgttct tgt agacgaacataatgtaccgctcccgtttggaagtttaggtatacacaaaaagaaagaatataaaaactctaacatgt gtttgttcgtgtttgactgtttgtactttgatg gattcgatatgacggacattccattgtacgaacgaagatcttttctcaaaga tgttatggttgaaatacccaatagaatagtattctcagagttgacgaatattagtaacgagtctcagttaactgacgta ttg

-130-gatgatgcactaacgagaaaattagaaggattggtcttaaaagatattaatggagtatacgaaccgggaaagagaa gatggttaaaaataaagcgagactatttgaacgagggttccatggcagattctgccgatttagtagtactaggtgctta c tatggtaaaggagcaaagggtggtatcatggcagtctttctaatgggttgttacgacgatgaatccggtaaatggaaga cggttaccaagtgttcaggacacgatgataatacgttaagggagttgcaagaccaattaaagatgattaaaattaaca aggatcccaaaaaaattccagagtggttagtagttaataaaatctatattcccgattttgtagtagaggatccaaaaca atctcagatatgggaaatttcaggagcagagtttacatcttccaagtcccataccgcaaatggaatatccattagattt c ctagatttactaggataagagaggataaaacgtggaaagaatctactcatctaaacgatttagtaaacttgactaaatc ttaatagttacatacaaattaaaataacactatttagttggtggtcgccatggatggtgttattgtatactgtctaaac gcgtt agtaaaacatggcgaggaaataaatcatataaaaaatgatttcatgattaaaccatgttgtgaaaaagtcaagaacg ttcacattgg cgg acaatctaaaaacaatacagtgattgcagatttg ccatatatggataatgcg gtatccgatgtatg c aattcactgtataaaaagaatgtatcaagaatatccagatttgctaatttgataaagatagatgacgatgacaagactc ctactggtgtatataattattttaaacctaaagatg ccattcctgttattatatccataggaaaggatagagatgtttgtgaa ctattaatctcatctgataaagcgtgtgcgtgtatagagttaaattcatataaagtagccattcttcccatggatgttt ccttttt taccaaaggaaatgcatcattgattattctcctgtttgatttctctatcgatgcggcacctctcttaagaagtgtaacc gata ataatgttattatatctagacaccagcgtctacatgacgagcttccg agttccaattg gttcaagttttacataagtataaa gtccgactattgttctatattatatatggttgttgatggatctgtgatgcatgcaatagctgataatagaacttacgca aatat tagcaaaaatatattagacaatactacaattaacgatgagtgtagatgctgttattttg aaccacag attaggattcttg at agagatgagatgctcaatggatcatcgtgtgatatgaacagacattgtattatgatgaatttacctgatgtaggcgaat tt ggatctagtatgttggggaaatatgaacctgacatgattaagattgctctttcggtggctggtatttggaaagttttat aggt agttgatagaacaaaatacataattttgtaaaaataaatcactttttatactaatatgacacgattaccaatacttttg ttact aatatcattagtatacgctacaccttttcctcagacatctaaaaaaataggtgatgatgcaactttatcatgtaatcga aat aatacaaatgactacgttgttatgagtgcttggtataaggagcccaattccattattcttttagctgctaaaagcgacg tctt gtattttgataattataccaaggataaaatatcttacg actctccatacgatg atctagttacaactatcacaattaaatcat tgactgctagagatgccggtacttatgtatgtgcattctttatgacatcgcctacaaatgacactgataaagtagatta tga agaatactccacagagttgattgtaaatacagatagtgaatcgactatagacataatactatctggatctacacattca c cggaaactagttctgagaaacctgattatatagataattctaattg ctcgtcggtattcgaaatcgcg actccg gaacca attactgataatgtagaagatcatacagacaccgtcacatacactagtgatagcattaatacagtaagtgcatcatctg gagaatccacaacagacgagactccggaaccaattactgataaagaagaagatcatacagttacagacactgtct catacactacagtaagtacatcatctggaattgtcactactaaatcaaccaccgatgatgcggatctttatgatacgta c aatgataatgatacagtaccatcaactactgtaggcggtagtacaacctctattagcaattataaaaccaaggactttg t agaaatatttggtattaccgcattaattatattgtcggccgtg gcaatattctgtattacatattatatatataataaacgttca cgtaaatacaaaacagagaacaaagtctagatttttgacttacataaatgtctgggatagtaaaatctatcatattgag c gggccatctggtttaggaaagacagccatagccaaaagactatgggaatatatttggatttgtggtgtcccataccact agatttcctcgtcctatggaacgagaaggtgtcgattaccattacgttaacagagaggccatctggaagggaatagcc

-131-gccggaacatactgagtttttaggaaatatttacggaacttctaaaactgctgtgaatacagcggctattaataatcgt at ttgtgtgatggatctaaacatcgacggtgttagaagttttaaaaatacttacctaatgccttactcggtgtatataaga cct acctctcttaaaatggttgagaccaagcttcgttgtagaaacactgaagcggatgatgagattcatcgtcgtgtgatgt tg g caaaaactgacatg gatgag gcaggtgaag ccggtctattcgacactattatcattgaagatgatgtgaatttag cat atagtaagttaattcagatactacaggaccgtattagaatgtattttaacactaattagagacttaagacttaaaactt gat aattaataatataactcgtttttatatgtggctatttcaacgtctaatgtattagttaaatattaaaacttaccacgta aaactt aaaatttaaaatgatatttcattgacagatagatcacacattatgaactttcaaggacttgtgttaactgacaattgca aa aatcaatgggtcgttggaccattaataggaaaaggtg gatttggtagtatttatactactaatgacaataattatgtagta aaaatagagcccaaagctaacggatcattatttaccgaacaggcattttatactagagtacttaaaccatccgttatcg aagaatggaaaaaatctcacaatataaagcacgtaggtcttatcacgtgcaaggcatttggtctatacaaatccattaa tgtggaatatcgattcttggtaattaatagattaggtgcagatctagatgcggtgatcagagccaataataatagatta cc aaaaaggtcggtgatgttgatcggaatcgaaatcttaaataccatacaatttatgcacgagcaaggatattctcacgg agatattaaagcgagtaatatagtcttggatcaaatagataagaataaattatatctagtggattacggattggtttct aa attcatgtctaatggcgaacatgttccatttataag aaatccaaataaaatggataacggtactctag aatttacacctat ag attcgcataaaggatacgttgtatctagacgtggagatctagaaacacttgg atattgtatg attagatggttgg gag gtatcttgccatggactaagatatctgaaacaaagaattgtgcattagtaagtgccacaaaacagaaatatgttaaca atactgcgactligttaatgaccagtttgcaatatgcacctagagaattgctgcaatatattaccatggtaaactcttt gac atattttgaggaacccaattacgacaagtttcggcacatattaatgcagggtgtatattattaagtgtggtgtttggtt gatgt aaaatttttgtcgataaaaattaaaaaataacttaatttattattgatctcgtgtgtacaaccgaaatcatggcgatgt tttac gcacacgctctcggtgggtacgacgagaatcttcatgcctttcctggaatatcatcgactgttgccaatgatgtcagtt tat aataacaagtatgacattgtaaaagacaaatatatgtggtgttacagtcaggtgaacaagagatatattggagcactg ctgcctatgtttgagtgcaatgaatatctacaaattg gagatccgatccatgatcaagaag gaaatcacatatcg ccac aaaaactactatgctctaagcggaatcgggtacgagagtctagacttgtgtttggaaggagtagggattcatcatcac gtacttgaaacagaaaacgctgtatatggaaaagttcaacatgattattctactatcaaagagaaggccaaagaaat gaatgcactcagttcaggacctatcatcgattaccacgtctggataggagattgtatctgtcaagttactgctgtggac gt acatggaaaggaaattatgagaatgagattcaaaaagggtgcggtgcttccgatcccaaatctggtaaaagttaaac ttggggagaatgatacagaaaatctttcttctactatatcgg cggcaccatcg aggtaaccacctctctgg aagacagt gtgaatcatgtactcatgaaacgtttggaatctatacgccatatgtggtctgttgtatatgatcattttgatattgtga atggta aagaatgctgttatgtgcatacgcatttgtctaatcaaaatcttataccgagtactgtaaaaacaaatttgtacatgaa ga ctatgg gatcatgcattcaaatgagtatcttag cgaactgaaggaatcaggtg gatggagtcccagaccagaaatgc aggaatttgaatatccagatggagtggaagacactgaatcaattgagagattggtagaggagttcttcaatagatcag aacttcaggctggtaaatctattaatgttaaacatacatctgtttcagctaagcaactaagaacacgtatactctcatc tttt gccaacacagagggtggatatttgttcattggagttgataataatacacacaaagtatttggattcacggtgggttacg a ctacctcagactgatagagaatgatatagaaaagcatatcaaaagactttgtgttgtgtatttctgtgagaagaaagag

-132-gacatcaagtacacgtgtcgattcatcaaggtatataaacctg gggatgaggctacctcgacatacgtgtg cgctatc aaagtggaaagatgctgttgtgctgtgtttg cag attggccagaatcatggtatcaagaagtattctccag atgaatagg tgtcacatataaaattttaattaatgtaactatagagaacaaataataggttgtaatatcatatagacaataactaaca at taattagtaactgttatctctttttaactaactaactatacctattaatacatcgtaattatagttcttaacatctatt aatcattga ttcgcttctttaattttttataaaccaacattgttaattg aaaaggg ataacatgttacag aatataaattatatatggattttttt taaaaaggaaatacttgactggagtgtatatttatctcttcattatatagcacgcgtgttttccaatttttccacatcc catata atacaggattataatctcgttcgaacatacgagaaagtggataaaacaatagttgattttttatctaggttgccaaatt tatt ccatattttagaatatggggaaaatattctacatatttattctatggatgatgctaatacgaatattataatttttttt ctagata gagtattaaatattaataagaacgggtcatttatacacaatctcaggttatcatcatccattaatataaaagaatatgt ata tcaattagttaataatgatcatccagataataggataagactaatgcttgaaaatggacgtagaacaagacattttttg tc ctatatatcagatacagttaatatctatatatgtattttatatagatgccgaagacagttacggttgtacattattaca tagat gtatatatcactataagaaatcagaatcag aatcagaatcatacaatgaattaattaagatattgttaaataatg gatca gatgtagataaaaaagatacgtacggaaacacaccttttatcctattatgtaaacacgatatcaacaacgtggaattgt ttgagatatgtttagagaatgctaatatagactctgtagactttaatagatatacacctcttcattatgtctcatgtcg taata aatatg attttgtaaagttattaatttctaaaggagcaaatgttaatgcg cgtaataaattcggaactactccattttattgtg gaattatacacggtatctcgcttataaaactatatttggaatcagacacagagttagaaatagataatgaacatatagt t cgtcatttaataatttttgatgctgttgaatctttagattatctattatccagaggagttattgatattaactatcgta ctatttacg acgctgtcagttataatgcgtataatacgttggtctatctattaaacagaaatggtgattttgagacgattactactag tgg atgtacatgtatttcggaagcagtcgcaaacaacaacaaaataataatggaagtactattgtctaaacgaccatctttg aaaattatgatacagtctatgatagcaattactaaacataaacagcataatgcagatttattgaaaatgtgtataaaat a tactg cgtgtatgaccgattatgatactcttatagatgtacaatcactacag caatataaatggtatattttaagatgtttcg atgaaatagatatcatgaagagatgttatataaaaaataaaactgtattccaattagttttttgtatcaaagacattaa tac tttaatgagatacggtaaacatccttctttcgtgaagtgcactagtctcgacgtatacggaagtcgtgtacgtaatatc ata gcatctattagatatcgtcagagattaattagtctattatccaagaagctggatcctggagataaatggtcgtgttttc cta acgaaataaaatataacgataacgaactgtccacatatctaaaaatcttataaacactattaaaatataaaatcacact acatcattgtttccttttagtgctcgacagtgtatactatttttaacgctcataaataaaaatgaaaacgatttccgtt gttacg ttgttatgcgtactacctgctgttgtttattcaacatgtactgtacccactatgaataacgctaaattaacgtctaccg aaac atcgtttaataataaccagaaagttacgtttacatgtgatcagggatatcattcttcggatccaaatgctgtctgcgaa ac agataaatggaaatacgaaaatccatgcaaaaaaatgtgcacagtttctgattacatctctgaactatataataaacc gctatacgaagtgaattccaccatgacactaagttgcaacggcgaaacaaaatattttcgttgcgaagaaaaaaatg gaaatacttcttggaatgatactgttacgtgtcctaatgcggaatgtcaacctcttcaattagaacacggatcgtgtca ac cagttaaagaaaaatactcatttggggaatatataactatcaactgtgatgttggatatgaggttattggtgcttcgta cat aagttgtacagctaattcttggaatgttattccatcatgtcaacaaaaatgtgatataccgtctctatctaatggatta atttc cggatctacattttctatcg gtggcgttatacatcttagttgtaaaagtggttttatactaacg ggatctccatcatccacatg

-133-tatcgacggtaaatggaatcccatactcccaacatgtgtacgatctaacgaaaaatttgatccagtggatgatggtccc gacgatgagacagatttgagcaaactctcgaaagacgttgtacaatatgaacaagaaatagaatcgttagaagcaa cttatcatataatcatagtggcgttaacaattatgggcgtcatatttttaatctccgttatagtattagtligttcctg tgacaaa aataatgaccaatataagttccataaattgctaccgtgaatataaatccgttaaaataatgaataattaataattaata att taataacaaacaagtatcaaaagattaaagacttatagctagaatcaattgagatgtcttcttcagtggatgttgatat ct acgatgccgttagagcatttttactcaggcactattataacaagagatttattgtgtatggaagaagtaacgccatatt ac ataatatatacaggctatttacaagatgcgccgttataccgttcgatgatatagtacgtactatgccaaatgaatcacg tg ttaaacaatgggtgatggatacacttaatggtataatgatgaatgaacgcgatgtttctgtaagcgttggcaccggaat a ctattcatggaaatgtttttcgattacaataaaaatagtatcaacaatcaactaatgtatgatataattaatagcgtat ctat aattctagctaatgagagatatagaagcgclittaacgacgatggtatatacatccgtagaaatatgattaacaagttg t acggatacgcatctctaactactattggcacgatcgctggaggtgtttgttattatctgttgatgcatctagttagttt gtataa ataattatttcaatatactagttaaaattttaagattttaaatgtataaaaaactaataacgtttttatttgtaatagg tgcatta gcatcctattcgaataatgagtacactccgtttaataaactgagtgtaaaactctatatagatggagtagataatatag a aaattcatatactgatgataataatg aattggtgttaaattttaaagagtacacaatttctattattacag agtcatg cgacg tcggatttgattccatagatatag atgttataaacgactataaaattattgatatgtctactattcaacgcag aggtcacac gtgtagaatatctaccaaattatcatg ccattatgataagtacccttatattcacaaatatgatggtgatgag cgacaata ttctattactgcagagggaaaatgctataaaggaataaaatatgaaataagtatgatcaacgatgatactctattgaga aaacatactcttaaaattggatctacttatatatttg atcgtcatggacatagtaatacatattattcaaaatatgatttttaaa aatttaaaatatattatcacttcagtgacagtagtcaaataacaaacaacaccatgag atatattataattctcg cagtttt gttcattaatagtatacacgctaaaataactagttataagtttgaatccgtcaattttgattccaaaattgaatggact ggg gatggtctatacaatatatcccttaaaaattatggcatcaagacgtggcaaacaatgtatacaaatgtaccagaagga acatacgacatatccgcatttccaaagaatgatttcgtatctttctgggttaaatttgaacaaggcgattataaagtgg aa gagtattgtacgg gaccaccgactgtaacattaactg aatacgacgaccatccgtatgctactagaggtagcaaaaa gattcctatttacaaacgcggtgacatgtgtgatatctacttgttgtatacggctaacttcacattcggagattctaaa gaa ccagtaccatatgatatcgatgactacgattg cacgtctacag gttgcagcatagactttgtcacaacagaaaaagtgt gcgtgacagcacagggagccacagaagggtttctcgaaaaaattactccatggagttcgaaagtatgtctgacacct aaaaagagtgtatatacatgcgcaattagatccaaagaagatgttcccaatttcaaggacaaaatggccagagttat caagagaaaatttaactaaatttctcggtagcacatcaaatgatgttaccacttttcttagcatgcttaacttgactaa atat tcataactaatttttattaatgatacaaaaacgaaataaaactgcatattatacactggttaacgcccttataggctct aac cattttcaagatgaggtccctgattatagtccttctgttcccctctatcatctactccatgtctattagacgatgtgag aagac tgaagaggaaacatggggattgaaaatagggttgtgtataattgccaaagatttctatcccgaaagaactgattgcagt gttcatctcccaactgcaagtgaaggcaatggattcagggatatacgaaacaccgataaattataaaaaaagcaatg tgtccgctgtttccgttaataatactattttcgtaactggcggattattcataaataactctaatagcacgatcgtggt taaca atatggaaaaacttgacatttataaag acaaacaatggtcgattatagaaatg cctatggctagggtatatcacggcat

-134-cgactcgacatttggaatgttatattttgccggaggtctatccgttaccgaacaatatggtaatttagagaaaaacaac g agatatcttgttacaatcctagaacgaataagtggtttgatatttcatatactatttataagatatccatatcatcatt gtgtaa actaaataacgtcttctatgtatttagtaaggacattggatatgtggaaaagtatgatggtctccccgctataaaggca tt atcaacttctccttattgattgaaaatgaaaatataaatagtttttatgtatagcagtattaccctatagttttattgc ttactact aacatggatacagatacagatgttacaaatgtagaagatatcatgaatgaaatagatagagagaaagaagaaata ctaaaaaatgtagaaattgaaaataataaaaacattaacaagaatcatcccaatgaatatattagagaagcactcgtt attaatacaagtagtaatagtgattccattgataaag aagttatag aatgtatcagtcacgatgtagg aatatagatcat atctactaatttttataatcaatacaaaacataaaaaacaactcgttattacatagcaggcatggaatccttcaagtat tgt tttgataacgatggcaagaaatggattatcggaaatactttatattctggtaattcaatactctataaggtcagaaaaa att tcactagttcgttctacaattacgtaatgaagatagatcacaaatcacacaagccattgttgtctgaaatacgattcta tat atctgtattggatcctttgactatcgacaactggacacgggaacgtggtataaagtatttggctattccagatctgtat gga attggagaaaccgatgattatatgttcttcgttataaagaatttg ggaag agtattcg ccccaaaggatactgaatcagt cttcgaagcatgcgtcactatgataaacacgttagagtttatacactctcgaggatttacccatggaaaaatagaaccg aggaatatactgattagaaataaacgtctttcactaattgactattctagaactaacaaactatacaagagtggaaact cacatatagattacaacgaggacatgataacttcaggaaatatcaattatatgtgtgtagacaatcatcttggagcaac agtttcaaaacgaggagatttagaaatgttgggatattgcatgatagaatggttcggtggcaaacttccatggaaaaac gaaagtagtataaaagtaataaaacaaaaaaaagaatataaaaaatttatagctactttctttgaggactgttttcctg a aggaaatgaacctctggaattagttagatatatagaattagtatacacgttagattattctcaaactcctaattatgac ag actacgtag actgtttatacaagattgaaatattctttttttatag agtgtggtagtgttacggatatctaatattaatattaga ctatctctatcgcgctacacgaccaatatcgattactatggatatcttctatgaaaggagagaatgtattcatttctcc agc gtcaatctcgtcagtattgacaatactgtattatggagctaatggatccactgctgaacagctatcaaaatatgtagaa a aggaggagaacacggataaggttagcgctcagaatatctcattcaaatccatgaataaagtatatgggcgatattctg ccgtgtttaaagattcctttttgagaaaaattggcgataagtttcaaactgttgacttcactgattgtcgcactataga tgca atcaacaagtgtgtagatatctttactgaggggaaaatcaatccactattggatgaacaattgtctcctagcaattagt gc cgtatactttaaagcaaaatggttgacgccattcgaaaaggaatttaccagtgattatcccttttacgtatcaccaacg g aaatggtagacgtaagtatgatgtctatgtacggcgagctatttaatcacgcatctgtaaaagaatcattcggtaactt tt caatcatagaactgccatatgttggagatactagtatgatggtcattcttccagacaagattgatggattagaatccat a gaacaaaatctaacagatacaaattttaagaaatggtgtaactctctggaagctacgtttatcgatgttcacattccca a gtttaaggtaacaggctcgtataatctggtggatactctagtaaagtcaggactgacagaggtgttcggttcaactgga gattatagcaatatgtgtaatttagatgtgagtgtcgacg ctatgatccacaaaacgtatatagatgtcaatgaag agtat acagaagcagctgcagcaacttgtgcactggtgtcagactgtgcatcaacaattacaaatgagttctgtgtagatcatc cgttcatctatgtgattaggcatgttgatggaaaaatttttttcgttggtagatattgctctccgacaactaattgtta accattt tttttaaaaaaatagaaaaaacatgtggtattagtgcaggtcgttattcttccaattgcaattggtaagatgacggcca ac tttagtacccacgtcttttcaccacag cactgtggatgtg acag actg a ccagtattg atg acg tcaaa ca atgtttg a ct

-135-gaatatatttattggtcgtcctatgcataccgcaacaggcaatgcg ctggacaattgtattccacactcctctcttttag ag atgatgcggaattagtgttcatcgacattcgcgagctggtaaaaaatatgccgtgggatgatgtcaaagattgtgtaga aatcatccgttgttatataccggatgagcaaaaaaccatcatcggactttgtgcatatgctgctacttactggggaggt g aagaccatcccactagtaacagtctgaacgcattgtttgtgatgcttgagatgctaaattacgtggattataacatcat att ccggcgtatgaattgatgagttgtacatcttgacattttcttctttclictcttctccctttcccagaaacaaacttli tttacccac tataaaataaaatgagtatactacctgttatatttctlictatatttttttattcttcattcgttcagactlitaacgc gcctgaatgt atcgacaaagggcaatattttgcatcattcatggagttagaaaacgagccagtaatcttaccatgtcctcaaataaata cgctatcatccggatataatatattagatattttatgggaaaaacg aggagcggataatg atagaattataccgatagat aatggtagcaatatgctaattctgaacccgacacaatcagactctg gtatttatatatgcattaccacgaacgaaacct actgtgacatgatgtcgttaaatttgacaatcgtgtctgtctcagaatcaaatatagatcttatctcgtatccacaaat agta aatgagagatctactggcgaaatggtatgtcccaatattaatgcatttattgctagtaacgtaaacgcagatattatat gg agcgggcatcgacgccttagaaataagagacttaaacaacggacacctggaattattaccatagaagatgttagaa aaaatgatgctggttattatacatgtgttttagaatatatatacggtggcaaaacatataacgtaaccagaattgtaaa at tagaggtacgggataaaataataccttctactatgcaattaccagaaggtgttgtaacttcaataggtagtaatttgac ta ttgcgtgtagagtatcgttgagacctcccacaacggatgcagacgtcttttggataagtaatggtatgtattacgaaga a gatgatggggacggagacggtagaataagtgtagcaaataaaatctatatgaccgataagagacgtgttattacatc ccggttaaacattaatcctgtcaaggaagaagatgctacaacgtttacgtgtatggcgtttactattcctagcatcagc a aaacagttactgttagtataacgtgaatgtatgttgttacatttccatgtcaattgagtttataagaatlittatacat tatcttcc aacaaacaattgacgaacgtattgctatgattaactcccacgatactatgcatattattaatcattaacttgcagacta ta cctagtgctattttgacatactcatgttcttgtgtaattgcggtatctatattattaaagtacgtaaatctagctatag ttttattat ttaattttagataatataccgtctccttatttttaaaaattgccacatcctttattaaatcatgaatgggaatttctat gtcatcgtt aatatattgtgaacaacaagagcagatatctataggaaagggtggaatgcgatacattgatctatgtagttttaaaaca cacgcgaactttgaagaatttatataaatcattccatcgatacatccttctatgttgacatgtatatatccaggaattc ttttat taatgtcaggaaatgtataaactaaaacattgcccgaaag cggtgcctctatctgcgttatatccgttcttaacttacaaa atgtaaccaatacctttgcatgacttgttttgttcgg caacgttagtttaaacttgacg aatggattaattacaatag catga tccgcgcatctattaagtttttttactttaacgcccttgtatgtttttacagagactttatctaaatttctagtgcttg tatgtgttata aatataacgggatatagaactgaatcacctaccttagatacccaattacattttatcagatccagataataaacaaatt tt gtcgccctaactaattctatattgttatatattttacaattggttatgatatcatgtaataacttggagtctaacgcgc atcgtc gtacgtttatacaattgtgatttagtgtagtatatctacacatgtatttttccgcactatagtattctggactagtgat aaaact atcgttatatctgtcttcaatgaactcatcgagatattgctctctgtcatattcatacacctgcataaactlictagac atctta caatccgtgttattttaggatcatatttacatatttacgg gtatatcaaag atgttagattagttaatg ggaatcgtctataata atgaatattaaacaattatatgaggacttttaccacaaag catcataaaaatgagtcgtcgtctgatttatgttttaaatatc aaccgcgaatcaactcataaaatacaagagaatgaaatatatacatattttagtcattgcaatatagaccatacttcta c agaacttgattttgtagttaaaaactatgatctaaacagacgacaacctgtaactgggtatactgcactacactgctat tt

-136-gtataataattactttacaaacgatgtactgaagatattattaaatcatggagtggatgtaacgatgaaaaccagtagc g gacgtatgcctgthatatattgcttactagatgligtaatatttcacatgatgtagtgatagatatgatagacaaagat aaa aaccacttatcgcatagagactattccaacctactactagagtatataaaatctcgttacatgttattgaaggaagagg a tatcgatgagaacatagtatccactttattagataagggaatcgatcctaactttaaacaagacggatatacagcgtta c attattattatttgtgtctcgcacacgtttataaaccaggtgagtgtagaaaaccgataacgataaaaaaggccaagcg aattatttctttglitatacaacatggagctaatctaaacgcgttagataattgtggtaatacaccattccatttgtat cttagt attgaaatgtgtaataatattcatatgactaaaatgctgttgacttttaatccgaatttcaaaatatgtaataatcatg gatta acgcctatactatgttatataacttccgactacatacaacacgatattcttgttatgttaatacatcactatgaaacaa atgt tggagaaatgccgatagatgagcgtcgtataatcgtattcgagtttatcaaaacatattctacacgtccggcagattcg a taacttatttgatg aataggtttaaaaatatagatatttatacccgctatgaag gaaag acattattacacgtagcatgtg a atataataatacacacgtaatag attatcttatacgtatcaacggagatataaatg cgttaaccgacaataacaaacac g ctacacaactcattatagataacaaag aaaattccccatataccattaattgtttactgtatatacttag atatattgtaga taagaatgtgataagatcgttggtggatcaacttccatctctacctatcttcgatataaaatcatttgagaaattcata tcct actgtatacttttagatgacacattttacaatagacacgttaggaatcgcaattctaaaacgtatcgatacgcattttc aaa atacatgtcgtttgataaatacgatggtataataactaaatgtcataaagaaacaatattgctcaaactatccactgtt ct agacactacactatatgcagttttaagatgccataattcgaaaaagttaagaagatacctcaacgagttaaaaaaata taataacgataagtcctttaaaatatattctaatattatgaatgagagataccttaatgtatattataaagatatgtac gtgt caaaggtatatgataaactatttcctgttttcacagataaaaattgtctactaacattactaccttcagaaattatata cgaa atattatacatgctgacaattaacgatctttataatatatcgtatccacctaccaaagtatagttgtatttttctcatg cgatgt gtgtaaaaaaactgatattatataaatattttagtgccgtataatgaagatgacgatgaaaatgatggtacatatatat ttc gtatcattattgttattgctattccacagttacg ccatagacatcgaaaatgaaatcacagaattcttcaataaaatgaga gatactctaccagctaaagactctaaatggttgaatccagcatgtatgttcggaggcacaatgaatgatatagccgctc taggagagccattcagcgcaaagtgtcctcctattgaagacagtcttttatcgcacagatataaagactatgtggttaa a tgggagaggctagaaaaaaatagacggcgacaggtttctaataaacgtgttaaacatggtgatttatggatagccaa ctatacatctaaattcagtaaccgtaggtatttgtgtaccgtaactacaaagaatggtgactgtgttcagggtatagtt ag atctcatattaaaaaacctccttcatgcattccaaaaacatatgaactaggtactcatgataagtatggcatagactta ta ctgtggaattctttacgcaaaacattataataatataacttggtataaagataataaggaaattaatatcgacgatatt aa gtattcacaaacgggaaagaaattaattattcataatccagagttagaagatagtggaagatacaactgttacgttcat t acgacgacgttagaatcaagatgtaaaatacttacggttataccgtcgcaagaccacaggtttaaactaatactagat ccaaaaatcaacgtaacgataggag aacctg ccaatataacatgcactgctgtgtcaacgtcattattg attgacgat gtactgattgaatgggaaaatccatccggatggcttataggattcgattttgatgtatactctgttttaactagtagag gcg gtatcaccgaggcgaccligtactttgaaaatgttactgaagaatatataggtaatacatataaatgtcgtggacacaa ctattattttgaaaaaacccttacaactacagtagtattggagtaaatacacaatgcatlittatatacattactgaat aatt attattattatttatatcgtatttgtgctataacgcgactatctaggtatttgtatctcaccgatagagaacatataaa tgtaga

-137-ctctattaaacagttgtgtaaaatatcagatcctaatagatgtgg atgtacggctttagaaatgagttcattaaaatatgtg atatcaacggaacatatttatataattatactattgctgttagtataattattgattccacggaagaactaccaacagt tact ccaattacaacaacatataattatactatcgatgatag cactactg aagaactacaagtgactcctcatatggatctcca tcgatgatacatgtattaaaatactttccgaataagtcttttaaatattgtattaattatgaaaaactatgctatgcga gtatg atacgatactagattttatctctagcgagagatgtcgttagaatcatttatcaacgaatatcgataacatgtgtcattt atac gttaaagtctgtccgtcttctctattgtttagactgtttgtagaatgctgtgatataaacaaactagtagacacaaata tttaa ctcatgatgaagttgagaatgatatgctttagctaatataaaaatatattaatccactatatattctagacttgattta aaac cgataaactactactacgtactgtataagttaggagcagaccctaattatgtagatgatagaggtaatacttctgcatc ta tatgtccacttatgagaaaacgtcatttaataagatgcatcgtgaaaagaaatttattaaagagttggtaaaatatgaa a ccgaaagtaaataatataggaaatacacctctacataactacgtatctcaatatgatatcactctcattcctcatccac a acccattaaaaaatggaaattaaagccctctattagcataaacgg ctacaggtctacctttacaatggcctttccttgtgc ccagttcagaccctgtcattgccacgctactaaggactccctgaataccgtggccgacgtcagacattgtctgactgaa tacatcctgtgggtttctcatagatgg acccatagagaaag cgcagggtctctctacagg cttctcatctctttcagaact gatgcaacggagctctttggtggtgagttgaag gattcacttccgtggagatcattaaatgactccatgaaaaccgccg aagaacttcgtgcaatcattggactttgtactcaatcagctatcgtctctggaagagtcttcaacgataagtatatcga ca tactacttatgctgcgaaagattctgaacgag aacgactatctcaccctcttggatcatatccg cactgctaaatactaa atctccttcatgctctctcactacactttttatcatcttatgaggaataattagcaccagaatagctatggattgcaca tgtatt ctatgtcgtctactggatgaagatgtgacgtacaaaaaaataaaactagaaattgaaacgtgtcacaacttatcaaaa catatagatagacgagg aaacaatgcgctacattgttacgtctccaataaatg cgatacagacattaagattgttcgac tgttactctctcgcggagtcgagagactttgtagaaacaacgaaggattaactccgctaggagcatacagtaagcata gatacgtaaaatctcagattgtg catctactgatatccag ctattcgaattcctctaacgaactcaagtcgaatataaatg atttcgacttacgtctgctaaaatacctaattgtgg ataaacggatacgtccgtccaagaatacgaattatgcaatcaat ggtctcggattggtggatatatacgtaacgacgcctaatccgagaccagaagtattgctatggcttcttaaatcagaat g ttacagcaccggttacgtatttcgtacctgtatgtacaacagtgatatgtgtaagaactctcttcattactatatatcg tctca tagagaatctctatccaaggatgtaattaaatgtttgatcgataacaatgtttccatccaatactactggtcttgctca acc atagatatagagattattaataaaggatgtggacacgtgtag agtatacgacgtcag ccctatattagaggcgtattatc taaacaagcgatttagagtaaccccatataatgtagacatggaaatcgttaatcttcttattgagagacgtcatactct tgt cgacgtaatgcgtagtattacttcgtacgattccagag aatataaccactacatcatcg ataacattctaaagagattta gacaacaggatgaatccatcgtacaagccatactgataaactacttacattacggcgatatggtaagtatacctatcat tcaatg catgttg gataagacgacggacaacaactttgttaataataatctcgtcgatgtaaacgtcgtaaggtttatcgt ggaaaatatggacacgcggctgtaaatcacatatctaacaatggccgtctatgtatgtacggtctgatattatcgagat tt aataattgcgggtatcactgttatgaagatgtatttgatatactaagcaagtacatggatgatatagatatgatcgata ac tctactatattacgcggtcgatgtcaataatatacaatttgcaaagcggttattggaatatggagcgagtgtcacgctc ga taatcaatacg gccatccagaaaag cagttaccaaagagaagctagttgatttattactg agttaccatcccactctag

-138-agactatgattgacgcatttaatagagatatacgctatctatatcctgaaccattattcgcctgtatcagatacgcctt aat cctagatgatgattttccttctaaagtaagtatgatatcgccggtcgtcataaggaactaaagcgctatagagcagaca t taatagaatgaagaatg cctacatatcaggcgtctccatgtttg atatattatttaaacgaagcaaacgccacagattga gatacgcaaagaacaatgagaggatcgactccattaaataatttatcatggagtgataatgtcctgtttccatggcata t tacaaaatcgattccgtccaagatgataaaaacatttaccgg catcataaacacggagtttattttatatgtctcgcataa acattactaaaaaaatatattgttcggttttctttcacatctttaattatgaaaaagtaaatcattatgagatggacgc atcgt tcgcgacagtatgtggtacatacctaacgtatttatggacgacggtaagaatgaaggtcacgtttctgtcaacaatgtc g acgcgatcgtgtaacacgactcacaatagaatctgtg aatgctctcccgatcatggatgcaaggcatgtgtttcccaaa caaaatgtggaataggatacggagtatccggagacgtcatctgttctccgtgtggtctcggaacatattctcacaccgt c tcttccgcagataaatgcgaacccgtacccagaaatacctttaactatatcgatgtggaaattaacctgtatccagtta a cgacacatcgtgtactcggacgaccactaccggtctcagcgaatccatctcaacgtcggaactaactattactatgaat cataaagactgcgatcccgtcttcttaataaggtagcgacttcaggtttctttacaggagaaaggtgtgcactctgaat tt cgagattaaatgcaataacaaagattcttcctccaaacagttaacgaaagcaaagaatgatactatcatgccgcattc ggagacagtaactctagcgtcgacatctatatactatatagtaataccaatactcaagactacgaaactgatacaatct cttatcatgtgggtaatgtagccatatgcccggtagttgcgatatacataaactgatcactaattccaaacccacccgc tt tttatagtaagtttttcacccataaatacaataattaatttctcgtaaaagtagaaaatatattctaatttattgcacg gtaag gaagtagaatcataaagaacagtactcaatcaatagcaatcatgaaacaatatatcgtactggcatgcatgtgcctgc cagtcttcagcaatcatcctcatcgtgtacggaag aagaaaacaaacatcatatgggaatcgatgttattatcaaagtc acaaagcaagaccaaacaccgaccgatgataagatttgccaatccgtaacggaaattacagagtccgagtcagat ccagatcccg aggtggaatcagtcgaggatgtag atcctcctaccacttattactccatcatcggtggaggtctgagaa tgaactttggattcaccaaatgtcctcagattaaatccatctcagaatccgctgatggaaagactgtgaggtgtctatc g acatcagatgtagcgaagaagagaaagacagcgacatcaagacccatccagtactcgggtctaacatctctcataa gaaagtgagttacgaagatatcatcggttcaacgatcgtcgatacaaaatgtgtcaagaatctagagtttagcgttcgt atcggagacatgtgcaaggaatcatctgaacttgaggtcaagtatgtcgacggatcggcatctgaaggtgcaaccga tgatacttcactcatcgattcaacaaaactcaaag cgtgtgtctgaatcgataactctattcatctgaaattggatgagta gggttaatcgaacgattcaggcacaccacgaattaaaaaagtgtaccggacactatattccggtttgcaaaacaaaa agttacctctcgcgacttcttctlittctgtctcaatagtgtgatacgattatgacactattcctatttcctttcaggg tatcacaa aaatattaaacctctttctgatggtctcatacaaaaatatlittattctctttctctctttgatggtctcataaaaaat atttttattct ctttctctctttgatggtctcataaaatatttttattctctttctctctttgatggtctcataaaaaatatttttattc tctttctctctttga tggtctcataaaatatttttattctctttctctctttgatggtctcataaaaaatattlitattctctttctctctttg atggtctcataaa aaatattaaacctctttctgatggtgtcactaaaatatttttattctctttctctcttcaatggagtcataaaatattt ttattctcttt ctctcttcgatggtctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctctttctctctt caatggagt cataaaatatttttattctctttctctctttgatggtctcacaaaaatatttttattctctttctctctttgatggtct cacaaaaatatt tttattctctttctctctttgatggtctcacaaaaatatttttattctctttctctctttgatggtctcataaaaaaag ttttacaaaaa

-139-tatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctclitctctctttg atggtctcataaa aaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaatattaaacctctttctgatggt gtcactaa aatatttttattctcattctctcttcaatggagtcataaaatatttttattctctttctctcttcgatggtctcacaaa aatattaaac ctctttctgatggtgtcactaaaatatttttattctcattctctcttcaatggagtcataaaatatttttattctcttt ctctcttcgatg gtctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctclicaatggagtcat aaaatat ttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatg gtctcataaaaa atattaaacctctttctgatggtgtcactaaaatatttttattctctlictctcttcaatggagtcataaaatattttt attctctttctc tcttcgatggtctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctcttcaa tggagtc ataaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctc tctttgatggtct cataaaaaaaglittacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatat ttttattct ctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataa aaaatattaa acctctttctgatggtgtcactaaaatatttttattctcattctctcttcaatggagtcataaaatatttttattctct ttctctcttcga tggtctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctclicaatggagtc ataaaat atttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttga tggtctcataaa aaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttat tctctttctct ctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcacaaaaatatta aacctcttt ctgatggagtcgtaaaaaagttttatctctttctccttcgatggtctcacaaaaatattaaacctclitctgatggagt cgtaa aaaagttttatctctttctctcttcgatggtctcacaaaaatattaaacctclitctgatggagtcgtaaaaaagtttt atctcttt ctctcttcgatggtctcactaaaatattttttattctctttctg atgcatcaactatttcttaaacaataacgtccaacaacatat actcgtcgagcttatcaacatcccctatgcccatctaggttaccag acaattgtatatcataaaataatgtttataatttttac aaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctct ctttgatggtct cataaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctclicaatggagtcataaa atattttt attctctttctctcttcgatggtctcacaaaaatattaaacctclitctgatggtgtcactaaaatatttttattctca ttctctcttc aatgg agtcataaaatatttttattctctttctctctttgatg gtctcataaaaaaagttttacaaaaatatttttattctctttctctc tttgatggtctcataaaaaaaglittacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttt tacaaaa atatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctcttt gatggtctcataa aaaaagttttacaaaaatatttttattctctttctctctttg atggtctcataaaaaaagttttacaaaaatatttttattctctttct ctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaata ttaaacct ctttctgatggtgtcactaaaatatttttattctctttctctcttcaatggagtcataaaatatttttattctctttct ctcttcgatggt ctcacaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattctctcttcaatggagtcataa aatatttt tattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtc tcataaaaaa agttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattct ctttctctctttg atggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttaca aaaatat ttttattctctttctctctttgatggtctcataaaaaatattaaacctctttctgatggtgtcactaaaatatttttat tctctttctctct

-140-tcaatggagtcataaaatatttttattctctttctctcttcgatggtctcacaaaaatattaaacctclitctgatggt gtcacta aaatatttttattctctttctctcttcaatggagtcataaaatatttttattctctttctctctttgatggtctcataa aaaaagttttac aaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctct ctttgatggtct cataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatat ttttattct ctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttctctctttgatggtctcataa aaaaagtttt acaaaaatatttttattctctttctctctttgatggtctcataaaaaaagttttacaaaaatatttttattctctttct ctctttgatggt ctcataaaaaatattaaacctctttctgatggtgtcactaaaatatttttattctcattttctctttctctcttcaatg gagtcataa a atatttttattctctttctctctttg atggtctcataaaaaatattaaacctctttctg atg gtgtcactaaaatatttttattctcatt ctctcttcaatggagtcataaaaaagttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctg atggag tcgtaaaaaagttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatgcatcaactattt cttaaac aataacgtccaacaacatatactcatcccctatgcccatctaggttaccagacaattgtatatcataaaataatgttta ta atttacacgttaaaatcatataataaaacgtagatcgtataatatlitttggtatataaatgatctagtaaaatccatg tagg g g atactg ctcacattttttctttg gta caaaatttcacacaag tttttatacag a caaattcttgtccatatattttaaaacatt gactlitgtactaagaaaaatatctagactaactatctctttctctttctctcttcgatggtctttctgatggagtcgt aaaaaa gttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttttatct ctttctctct tcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttttatctctttctccttcgatggtct cacaa aaatattaaacctctttctgatggagtcgtaaaaaagttttatctctttctctcttcgatggtctcacaaaaatattaa acctct ttctg atg gtg tcactaaa atatttttattctctttctctcttcg atg gtctca caa aaatatta aacctctttctg atg g ag tcgt aaaaaagttttatctctttctccttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttt tatctc tttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaaglittatctctttctcctt cgatggtc tcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttttatctctttctccttcgatggtctcacaaaaat attaa a cctctttctg atggagtcg taaaaaagttttatctctttctccttcg atggtctcacaaaaatattaaacctctttctg atg ga gtcgtaaaaaagttttatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaa aagttt tatctctttctctcttcgatggtctcacaaaaatattaaacctctttctgatggagtcgtaaaaaagttttatctcttt ctccttcg atggtctcacaaaaatattaaacctctttctgatagtctctataaagcgattgatttttcttaccctctagagtttcct acggtc gttggtcacacattthttctagacactaaataaatagtaagattaaattaattataaaattatgtatataatattaatt ataaa attatgtatatgatttactaactttagttagataaattaataatacataaattttagtatattaatattataaattaat aatacata aattttagtatattaatattatattttaaatatttatttagtgtctagaaaaaaaggccggcctagcaggcc [0076] Also disclosed are examples of synthetic Vaccinia virus (sVAC) fragments to reconstitute the complete Vaccinia virus genome. An example sequence of sVAC fragment 1 (F1, 66679 bp in length) (SEQ ID NO: 16):
thttttctagacactaaataaaatatttaaaatataatattaatgtactaaaacttatatattattaatttatctaact aaagtta gtaaattatatatataattttataattaatttaattttactaattttatttagtgtctagaaaaaaatgtgtgacccat gactgtag

-141-gaaactctagagtgtaagaaagatcgatcgctttatagagaccatcagaaagaggtttaatatttttgtgagaccatcg aagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagaga aagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaa acttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaaggagaaagagataaaactthttacg a ctccatcagaaagaggtttaatattlitgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcag aaagaggtttaatattlitgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagaggtt t aatatttttgtgagaccatcgaaggagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttg tga gaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcga agagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaa agagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaa acttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaactttttta cg actccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagaaagagatagttgatctagatattt ttcttagtacaaaagtcaatgttttaaaatatatggacaagaatttgtctgtataaaaacttgtgtgaaattttgtacc aaag aaaaaatgtgagcagtatcccctacatggattttactagatcatttatataccaaaaaatattatacgatctacgtttt atta tatgattttaacgtgtaaattataaacattattttatgatatacaattgtctggtaacctagatgggcataggggatgt tgata agctcgacgagtatatgttgttggacgttattgtttaagaaatagttgatgcatcagaaagagaataaaaaatatttta gt gagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatc gaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagag aaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagata aaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttt ta cgactccatcagaaagaggtttaatatlittgtgagaccatcgaagagagaaagagataaaacttttttacgactccat c agaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagag gtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatat tttt gtgagaccatcgaagagagaaagagataaaactlitttacgactccatcagaaagaggtttaatatttttgtgagacca tcgaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagaga gaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagat aaaacttttttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaactlit tt acgactccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttacgactcca tcagaaagagglitaatatttttgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaaga ggtttaatatttttgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaata ttt ttgtgagaccatcgaagagagaaagagataaaacttttttacgactccatcagaaagaggtttaatatttttgtgagac c atcgaagagagaaagagataaaactlitttacgactccatcagaaagaggtttaatatttttgtgagaccatcgaagag agaaagagaataaaaatattttatgactccattgaagagagaaagagaaaatgagaatgagaataaaaatatttta gtgacaccatcagaaagaggtttaatatttttgtgagaccatcgaagagagaaagagaataaaaatattttatgactcc

-142-attgaagagagaaagagaaaatgagaatgagaataaaaatattttagtgacaccatcagaaagagglitaatattlitt atgagaccatcaaagagagaaagagaataaaaatatttligtaaaactlittttatgagaccatcaaagagagaaag agaataaaaatatttligtaaaacttlitttatgagaccatcaaagagagaaagagaataaaaatattlitgtaaaact litt ttatgagaccatcaaagagagaaagagaataaaaatatttligtaaaacttlitttatgagaccatcaaagagagaaa gagaataaaaatatlittgtaaaactlittttatgagaccatcaaagagagaaagagaataaaaatattlitgtaaaac ttt littatgagaccatcaaagagagaaagagaataaaaatattlitgtaaaactlittttatgagaccatcaaagagagaa agagaataaaaatattlitgtaaaacttlitttatgagaccatcagaaagagglitaatattlitgtgataccctgaaa gga aataggaataggaataggaatagtgtcataatcgtatcacactattgagacagaaaaagaagaagtcgcgagagg taactlittgtgaatgtagttaagaacattlitglittgcaaaccggaatatagtgtccggtacacttlittaattcgt ggtgtgc ctgaatcgttcgattaaccctactcatccaatttcagatgaatagagttatcgattcagacacacgctttgaglittgt tgaa tcgatgagtgaagtatcatcggttgcaccttcagatgccgatccgtcgacatacttaaatccatccttgacctcaagtt ca gatgattccttgcacatgtctccgatacg aacgctaaactctag attcttg acacattttgtatcg acg atcgttgaaccga tgatatcttcgtaactcactlicttatgagagatgttagacccgagtactggatgggtcttgatgtcgctgtctlictc licttcg ctacatctg atgtcgatagacacctcacagtctttg atcatagccagagclicttcatgagtgatcgcgggagagtcctta ccligtcctggggacacgctggacaatctagcattcactgtglitccatcagcggattctgagatggatttaatctgag ga catttggtgaatccaaagttcattctcagacctccaccgatg atggagtaataagtggtaggagg atctacatcctcga ctgatgtggaatcatcttctgattccacctcg ggatctggatctgactcgg actctgtaatttccgttacggattg gcaaatc ttatcattggtcggtglitggtcttgctttgtgactttgataataacatcgattcccatatgatglitglittclictt ccgtacacga ggaggaggatgaggatgattgctgaagactggcaggcacatgcatgccaggacgatatattglitcatgattgctattg attgagtactglictttatgattctacttccttaccgtgcaataaattagaatatattlictactlitacgagaaatta attattgta tttattatttatgggtgaaaaacttactataaaaag cgggtg gglitggaattagtgatcagtttatgtatatcgcaactacc gggcatatggctatcgacatcgagaacattacccacatgataagagattgtatcagtttcgtagtcttgagtattggta tt actatatagtatatagatgtcgacgctagatagacagtctccgaatgcggcatgataccgtcatcattclitgclitcg tta actglitggaggaaaaattlitgttattgcatttaatctcgaaattcagagtgcacacclitctcctgtaaagaaacct gaag ttgctaccttattaagg acg gagaagtattcctcacgaaatacgggattacagtclitatgattcatagtaatagttagttcc gacgttgagatggattcgctgagaccggtagtggtcgttaactggatacagattaatttccacatcgatatagttaaag g tattactgggtacgggttcgcatttatctgcggaagagacggtgtgagaatatgliccgagaccacacggagaacaga tgacgtctccggatactccgtatcctattccacattttglitgggaaacacatgccttgcatccggatgatcctttgag aag acaataatatccgggagagcattcacagattctattgtgagtcgtgttacacggtcgcgtcttccgttacaacttagac a agcgggtaaatgattattgcgagatgtgaaggtacccgaaccacacggcgtacattgtgtgttagtcttgctatcgcat a atctggaagcgtatglicccggacacaaattatggcgtligtattcgttgtctttacactttccatcggatggtgcatg cggt g ctatatctcttccgtttattattatacatg agagaaacaatatatacgagtataatacgg acttcatgatttaataatgtagt aatcgtcgtcttglicctglitcctacttctccaatcatatagatattlictlictatcatggataatatttgtaatgg lictlitcgta caacatactgtttag atgatattg cgcataatttccggaggcaaatacg atagtctagattgaccgatggtagactctaat

-143-ttattgagtgctttgtcgacgagtttacttttacgctccatcgatagatggcactgttctatgagatcgtcgtacatgg gaaat gaaatgtg actgtctgaatgtatggctttaag atagctgtgataccgtatacaggtcg gtgtcggagattcgaatctcttta aggcgacttatgtcacgatgatggaatctatcttatcgaatg atatatttttcataaatacacttttatagtcctcgtttaaaca g aatttactatgtagttccgcgaatgactcgtcccttaataggcagtag gctattatcttctttacgtagtaatcgtcgtag g gagagacatcttgtagaacaacgatttaatcataggtagagatactttcagtctgtggtggatgatgtcattcacaaca t ccgccttgtatatgatglitctgttttcaaacaccaagtcgaataccgtctttagtcggaaggttgatgtcgtatccga tgtat gaggcaacattgttgttacaattttgaaag gcggtattatagtattcgtctttctg aatgtcgaacctatctagtag ataccg tagtatattg agagtgtatccttgattatgttttatg aatagataaagtagatgttgtccttcttccttttgttcgtg ccaattgagt aacattatgagaatatgacctgttgcacaatcgttccatg atgggtgtacaatcaagattattacgtatcctcgtatcgg ct cctcgagataaaagagcatacaccacacgaggactatgtttggtatactgttgaaggtaagtgtgtaaccgcgttaatg tttgctccataatctattatcgcgtagatgaatcgcttctcggctcgcatcttagtgtgacttaacttgtaataattgc ttligta gaacgtggatatgtgtttacagtagtaatgaagagaagtgagttcatcctcgtcggatcctttgtacagaacgtaatag tt taagctcccattgaatttatatctaagataacacag caatagatcgg atgatttactaaagtcatcaatggtgtccgttagt atatcaaagatcttgttatcgattgatagtg gtgtcctttttcatccttgctatcaaagttacg catgccgtggtgtaacaatat ctttaatacagatggattaaatcgtgtattcatcgtatagcaatgtaatggagagttacctcgtttattcagatcgcag tgttt aataactagcttaaacagatgagacgatgtatccacatcaaagaacgtgaaatacatatgacagacattgttgacag aaacgtgaccttcattcttaccgtcgtccataaatacgttag gtatgtaccacatactgtcgcgaacgatgcgtacaatct cgtccatctcataatg atttactttttcataattaaagatgtg aaagaaaaacagaacaatatatttttttagtaatgtttatgc gagacatataaaataaactccgtgtttatgatcatttttaacagcaacacattcaatattgtattgttatttttatatt atttaca caattaacaatatattattagtttatattactgaattaataatataaaattcccaatcttgtcataaacacacactgag aaa cagcataaacacaaaatccatcaaaaatgtcgatgaaatatctgatgttgttgttcgctgctatgataatcagatcatt cg ccgatagtggtaacgctatcgaaacgacatcgccagaaattacaaacgctacaacagatattccagctatcagattat gcggtccagagggagatggatattgtttacacggtgactgtatccacgctagagatattgacggtatgtattgtagatg c tctcatggttatacaggcattagatgtcagcatgtagtattagtagactatcaacgttcagaaaacccaaacactacaa cgtcatatatcccatctcccggtattatgcttgtattagtaggcattattattattacgtgttgtctattatctgttta taggttcact cgacgaactaaactacctatacaagatatggttgtgccataatttttataaatttttttatgagtatlittacaaaaaa aatgt ataaagtgtatgtcttatgtatatttataaaaatgctaagtatg cgatgtatctatgttatttgtatttatctaaacaatacctcta cctctagatattatacaaaaattttttatttcggcatattaaagtaaaatctagttaccttgaaaatgaatacagtggg tggtt ccgtatcaccagtaagaacataatagtcgaatacagtatccgattgagattttgcatacaatactagtctagaaagaaa tttgtaatcatcttctgtgacgggagtccatatatctgtatcatcgtctagtttatcagtgtcccatgctatattcctg ttatcatc attagttaatgaaaataactctcgtgcttcagaaaagtcaaatattgtatccatacatacatctccaaaactatcgctt ata cgtttatctttaacgatacctatacctagatggttatttactaacagacattttccagatctattgactataactccta tagtttc cacatcaaccaagtaatgatcatctattgttatataacaataacataactcttttccatttttatcagtatgtatatct atatca acgtcgtcgttgtagtgaatagtagtcattgatctattatatgaaacggatatgtctagaacggcaattgttttacgtc cagt

-144-taacactttctttgatttaaagtctagagtctttg caaacataatatccttatccgactttatatttcctgtagg gtggtataatttt attttgcctccacatatcggtglitccaaatatattactagacaatattccatatagttattagttaagggtacccaat tagaa cacgtacgcttattatcatcatttggatcgtatttcataaaagttattgtactatcgatgtcaacacattctacatttt ttaatcgt ctatatagtatttttctgatattttctataatatcagaattgtcttccatcggaagttgtatactatcggaatcagtta catgttta aataattctctgatgtcattccttatacaatcaaattcattattaaacagtttaatagtctgtagacctttatcgtcgt aaatatc cattgtcttattagttacgcttatttttatgtgttttacgttgctttattatattttataagaatgattgtttgacgaa tcacgagaact attaagacacattattaggtatatattataaaaaagtttttgattacgatgttataagaggaaagaggacacattaaca tc atacatcaattaactacattcttataacatcgtaatcaaaagaattg caattttgatgtataacaactgtcaatgggttatg gaattgtatattacatattatacggtatgttggtaacgacaaataccgatcggtaattgtctgccggtgtaatagaatt atat atatctatctattacaccggctgagtatgcataataataagttgtggtagtatgatctccatatttataatttaggact ttgtatt cagtattlitggaatcataaaaaataaaaaaaagttttactaatttaaaatttaaaaagtatttacatttttttcactg tttagtc gcggatatggaattcgatcctgccaaaatcaatacatcatctatagatcatgtaacaatattacaatacatagatgaac caaatgatataagactaacagtatgcattatccgaaatattaataacattacatattatatcaatatcacaaaaataaa t acacatttggctaatcaatttcgggcttggaaaaaacgtatcgccggaagggactatatgactaacttatctagagata caggaatacaacaatcaaaacttactgaaactatacgtaactgtcaaaaaaatagaaacatatatggtctatatatac actacaatttagttattaatgtggttattgattggataaccgatgtgattgttcaatcaatattaagagggttggtaaa ttggt acatag ctaataatacctatacacccaataatacaacaaccatttctgagttg gatatcatcaaaatactggataaata cgaggacgtgtatagagtaagtaaagaaaaagaatgtggaatttgctatgaagttgtttactcaaaacgatagatactt tggtttattggattcgtgtactcatatattttg cataacatgcatcaatatatggcataaaacacgaagagaaaccggtgc gtcggataattgtcctatatgtcgtacccgttttagaaacataacaatgagcaagttctataagctagttaactaataa at aaaaagtttaatttgttgacgacgtatgtcgttatttttctcgtatgaaagattaaattcaattcaattcgttgtttct aatataat ctgccgtattggatggattctcaagacaattgcatttagattatattatcatgaataaaaatagtagcacgcactactt cag ccaaatattcttttttgaaacgccatctatcgtagtgaggacacaagtgaacctataattatcaaatttattagtatca gtca catgaaggactttctgtagagtgacgattctaccatctatggtactaacggtttcatcctccttgataccctcacccaa atg ttctataaatttagcatcctcgtccgatctcatatcctttgccaaccaatacatgtagctaaaattaggcataaatttc acac atccagtgcaacgaaattctccagaagatgttacgatgtttaggttaggacatttgatttcgtcggcattaacatatgg gt gaacacacccatacatgaaagcgatgagaaataggattctcatcttgccaaaatatcactagaaaaaatttatttatca attttaaaggtataaaaaatacttattgttgctcgaatattttgtatttgatggtatacggaagattagaaatgtaggt attatc atcaactgattctatggttttatgtattctatcatgtttcactattgcgtcggaaataatatcatatgcttccacatat attttatttt gttttaactcataatactcacgtaattctggattattg gcatatctatg aataattttagctccatgatcagtaaatattaatg a gaacatagtattaccacctaccattatttttttcatttcgttcaattcttgattgcaaagatctatataatcattatag cgttgact tatggactctggaatcttagacgatgtacagtcatctataatcatggcatatttaatacattglittatagcatagtag ttatct acgatgttagatatttctctcaatgaatcaatcacacaatctaatgtaggtttatgacataatagcattttcagcagtt caat gtttctagattcgttgatggcaatggctatacatgtatatccgttatttgatctaatgttgacatctgaaccggattct agcagt

-145-aaagatactagagattgtttattatatctaacagccttgtgaagaagtgtttctcctcgtttgtcaatcatgttaatgt ctttaa gataaggtaggcaaatglitatagtactaagaattgggcaagcataagacatgtcacaaagaccctlittgtatgtata a gtgtaaaaattataacattcatagttg gatttacataggtgtccaatcgggatctctccatcatcgagataattgatgg cat ctcccttccttttttagtagatatttcatcgtgtaagaatcaatattaatatttctaaagtattcgtgtatagcctctt tatttacca cagttccatattccactagagggatatcgccgaatgtcatatactcaattagtatatgttggaggacatccgagttcat tgt tttcaatatcaaaaagatggtttccttatcatttctccatagtggtacaatactacacattattccgtg egg ctttccattttcca aaaacaatttgaccaaatctaaatctacatctttattgtatctataatcactatttagataatcagccataattactcg agtg caacatgttagatcgtctatatatg aataagcagtgttatctattcctttcattaacaatttaacgatg tctatatctatatgag atgacttaatataatattgaagagctgtacaatagtlittatctatagaagacggcttgattccgtgattaattagaca tttaa caacttccggacgcacatatgctctcgtatccgactttgaatacagatgagagatgatatacagatgcaatacggtacc g caatttcgtagttgataatcatcatacgcg tatcagtactcg tcctcataaagaacactgcagccattttctatgaacaa atcaataattttaggaacaggatcattgtcattacataattttctataactgaacgatggttttcacatttaacactca agtca aatccatgttctaccaacacctttatcaagtcaacgtctacatttttggatttcatatagctgaatatattaaagtcat ttatgtt gctaaatccagtggcttctagtagagccatcgctatatcctttaactttaacatgtctactatttgtgtattcttctaa tggggt agctgtctccaatttttgcgtaatggattagtgccactgtctagtagtagtttgacgacctcgacattattacaatgct catta aaaaggtatgcgtgtaaagcattattcttgaattggttcctggtatcattaggatctctgtctctcaacatctgtttaa gttcat cgagagccacctcctcattttccagatagtcaaacattttgactgaatgagctactgtgaactctatacacccacacaa c taatgtcattaaatattatttttttgaatgtatttataccatgtcaaaaacttgtacaattattaataaaaataattta gtgtttaa attttaccag ttccagattttacacctccgttaaccccactttttacaccactgg acgatcctcctccccacattccaccg cc accagatgtataagttttag atcctttattactaccatcatg tccatggataaagacactccacatgccg ccactactacc ccctttagaagacatattaataagacttaaggacaagtttaacaataaaattaatcacgagtaccctactaccaaccta cactattatatgattataglitctatlittacagtaccttaactaaagtctctagtcacaagagcaatactaccaacct acact attatatgattatagtttctatttttataggaacgcgtacgagaaaatcaaatgtctaatttctaacggtagtgttgat aaacg attatcgtcaatggatacctcctctatcatgtcgtctattttcttactttgttctattaacttattagcattatatatt atttgattataa aacttatattgcttattagcccaatctgtaaatatcggattattaacatatcgtlictttgtaggtttatttaacatgt acatcact gtaagcatgtccgtaccatttattttaatttgacgcatatccgcaatttctttttcgcagtcggttataaattctatat atgatgg atacatgctacatgtgtacttataatcgactaatatgaagtacttgatacatattttcagtaacgatttattattacca cctatg aataagtacctgtgatcgtctaggtaatcaactgttttcttaatacattcgatggttggtaatttactcagaataattt ccaat atcttaatatataattctgctatttctgggatatatttatctgccagtataacacaaatagtaatacatgtaaacccat attttg ttattatattaatgtctgcgccattatctattaaccattctactaggctgacactatgcgacttaatacaatgataaag tatac tacatccatgtttatctattttg tttatatcatcaatatacggcttacaaagttttag tatcgataacacatccaactcacgcat agagaaggtagggaataatgg cataatatttattag gttatcatcattgtcattatctacaactaagtttccattttttaaaat atactcgacaactttaggatctctattgccaaatttttgaaaatatttatttatatgcttaaatctatataatgtagct ccttcatc aatcatacatttaataacattgatgtatactgtatgataagatacatattctaacaatagatcttgtatagaatctgta tatctt

-146-ttaagaattgtggatattaggatattattacgtaaactattacacaattctaaaatataaaacgtatcacggtcgaata ata gttgatcaactatataattatcgattttgtgatttlicttcctaaactgtttacgtaaatagttagatagaatattcat tagttcatg accactatagttactatcgaataacgcgtcaaatatttcccgtttaatatcgcatttgtcaagataataatagagtgtg gtat gttcacgataagtataataacgcatctcttttttgtgtg aaattaaatagtttatcacgtccaaagatgtagcataaccatctt gtgacctagtaataatataataatagagaactgttttacccattctatcatcataatcagtggtgtagtcgtaatcgta atc gtctaattcatcatcccaattataatattcaccagcacgtctaatctgttctattttgatcttgtatccatactgtatg ttgctaca tgtaggtattcctttatccaataatagtttaaacacatctacattggg atttgatgttgtag cgtatttctctacaatattaatac catttttgatactatttatttctatacctttcgaaattagtaatttcaataagtctatatcgatgttatcagaacatag atattcg a atatatcaaaatcattgatatttttatagtcgactgacgacaataacaaaatcacaacatcgtttttgatattattatt tttcttg gtaacgtatgcctttaatggagtttcaccatcatactcatataatggatttgcaccactttctatcaatgattgtgcac tgctg gcatcgatgttaaatgttttacaactatcatagagtatcttatcgttaaccatgattggttgttgatgctatcgcattl ittggttt ctttcatttcagttatgtatggatttagcacgtttgg gaagcatgagctcatatgatttcagtactgtagtgtcagtactattag tttcgatcagatcaatgtctagatctatagaatcaaaacacgataggtcagaagataatgaatatctgtacgcttcttt ttg tactgtaacttctggttttgttagatggttgcatcgtgctttaacatcaatggtacaaattttatcctcgctttgtgta tcatattcg tctctagtataaaattctatattcagattatcatgcg atgtgtatacgctaacggtatcaataaacgg agcacaccatttag tcataacagtaatccaaaatlitttaaagtatatcttaacgaaagaagttgtgtcattgtctacggtgtatggtactag atcc tcataagtgtatatatctagagtaatgtttaatttattaaatg gttgataatatggatcctcatgacaatttccg aagatgg a aatgagatatagacatgcaataaatctaatcgaagacatggttactccttaaaaaaatacgaataatcaccttggctat ttagtaagtgtcatttaacactatactcatattaatccatggactcataatctctatacgggattaacggatgttctat atacg gggatgagtagttttcttctttaactttatactttttactaatcatatttagactgatgtatgggtaatagtgtttaaa gagttcgtt ctcatcatcagaataaatcaatatctctgtttttttgttatacagatgtattacagcctcatatattacgtaatagaac gtgtca tctaccttattaactttcaccgcatagttgtttgcaaatacggttaatcctttgacctcgtcgatttccgaccaatctg ggcgt ataatgaatctaaactttaatttcttgtaatcattcgaaataatttttagtttgcatccgtagttatcccctttatgta actgtaaa tttctcaacgcgatatctccattaataatg atgtcgaattcgtg ctgtatacccatactgaatggatg aactaacgaatatc aacggcgttaatagtaatttactttttcatctttacatattg ggtactagttttactatcataagtttataaattccacaagctact atggaataagccaaccatcttagtataccacacatgtcttaaagtttattaattaattacatgttgttttatatatatc gctacg aatttaaagagaaatcagtttaggaagaaaaaaattatctatctacatcatcacgtctctgtattctacgatagagtgc ta ctttaagatgagacatatccgtgtcatcaaaaatatactccattaaaatgattattccggcagcgaacttgatattgga tat atcacaacctttgttaatatctacgacaatagacagcagtcccatggttccataaacagtgagtttatctttctttgaa gcg atagtttgtagagatcttataaaaccgtcaaacgacatcgcatttatatclitagctaattcatatatgttaccatcgt aatat ctaaccgcgtctatcttaaacgtttccatcgctttaaagacgtttccgatagatggtctcatttcatcagtcatactga gcca acaaatataatcgtgtataacatctttgatagaatcagactctaaagaaaacgaatcggctttattatacgcattcatg at aaacttaatgaaaaatgtttttcgttgtttaagttggatgaatagtatgtcttaataattgttattatttcattaatta atatttagta acgagtacactctataaaaacgag aatgacataactagttatcaaagtgtctaggacgcgtaattttcatatg gtatag

-147-atcctgtaagcattgtctgtattctggagctattttctttatcgcattagtaagttcagaatatgttataaatttaaat cgaataa cgaacatgactttagtaaagtcgtctatattaactcttttattttctag ccatcg taataccatgtttaagatagtatattctcta gttactacgatctcatcgttgtctagaatatcacatactgaatctacatccaattttagaaattggtctgtgttacata tctctt ctatattattgttgatgtattgtcgtagaaaactattacgtagaccattttctttataaaacgaatatatagtactcca attatct ttaccgatatatttgcacacataatccattctctcaatcactacatctttaagattttcgttgttaagatatttggcta aactata taattctattagatcatcaacagaatcagtatatatttttctagatccaaagacgaactctttggcgtcctctataata ttccc agaaaagatattttcgtgttttagtttatcg agatctg atctgttcatatacgccatgattgtacggtacgttatgataaccgc ataaaataaaaatccattttcatttttaaccaatactattcataattg agattgatgtaatactttgttactttgaacgtaaag a cagtacacggatccgtatctccaacaagcacgtag taatcaaatttgg tgttgttaaacttcgcaatattcatcaatttag atagaaacttatactcatcatctgttttaggaatccatgtattattaccactttccaacttatcattatcccaggctat gtttcgt ccatcatcgttgcgcagagtgaataattcttttgtattcggtagttcaaatatatgatccatgcatagatcggcaaagc tatt gtagatgtgatttttcctaaatctaatataaaactcgtttactagcaaacactttcctgatttatcgaccaagacacat atgg tttctaaatctatcaagtggtggggatccatagttatgacgcagtaacatagattattacattcttgactgtcgctaat atcta aatatttattgttatcgtattggattctgcatatagatggcttgtatgtcaaagatatagaacacataaccaatttata gtcgc g ctttacattctcgaatctaaagttaagag atttagaaaacattatatcctcg gatg atgttatcactgtttctg gagtagg a tatattaaagtctttacagatttcgtccgattcaaataaatcactaaataatatcccacattatcatctgttagagtag tatca ttaaatctattatattttatgaaagatatatcactg ctcacctctatatttcgtacatttttaaactg tttgtataatatctctctg at acaatcagatatatctattgtgtcggtagacgataccgttacatttgaattaatggtgttccattttacaacttttaac aagtt gaccaattcatttctaatagtatcaaactctccatgattaaatattttaatagtatccattttatatcactacggacac aaagt agctgacataaaccattgtataatttttatgttttatgtttattagcgtacacattttggaagttccggcttccatgta tttcctgg agagcaagtagatgatgaggaaccagatagtttatatccgtacttgcacttaaagtctacattgtcgttgtatgagtat ga tcttttaaacccgctagacaagtatccgtttgatattgtaggatgtggacatttaacaatctgacacgtgggtggatcg ga ccattctcctcctgaacacaggacaccagagttaccaatcaacgaatatccactattgcaactataagttacaacgctc ccatcggtataaaaatcctcgtatccgttatgtcttccgttg gatatagatgg agggg attggcatttaacagattcacaa ataggtg cctcgggattccataccatagatccag tagatcctaattcacaatacgatttagattcaccgatcaaatgata tccgctattacaagagtacgttatactag agccaaagtctactccaccaatatcaagttggccattatcg atatctcgag gcgatgggcatctccgtttaatacattgattaaagagtgtccatccagtacctgtacatttagcatatataggtcccat ttttt gctttctgtatccaggtagacatagatattctatagtgtctcctatgttgtaattagcattagcatcagtctccacact attctt aaatttcatattaatgggtcgtgacggaatagtacag catgatagaacgcatcctattcccaacaatgtcaggaacgtc acgctctccaccttcatatttatttatccgtaaaaatgttatcctggacatcgtacaaataataaaaagcccatatatg ttcg ctattgtagaaattg tttttcacagttg ctcaaaaacgatgg cagtgacttatgagttacgttacactttg gagtctcatcttta gtaaacatatcataatattcgatattacgagttgacatatcgaacaaattccaagtatttgattttggataatattcgt attttg catctgctataattaagatataatcaccgcaagaacacacgaacatclitcctacatggttaaagtacatgtataattc ta tccatttgtcttccttaactatatatttgtatagataattacgagtctcgtgagtaattccagtaattacatagatgtc gccgtc

-148-g tactctacagcataaactatactatgatgtctaggcatg ggagacttttttatccaacgatttttagtgaaacattccacat cgtttaatactacatatttttcatacgtggtataaactccacccattacatatatatcatcgtttacgaataccgacgc gcct gaatatctaggagtaattaagtttggaagtcttatccatttcgaagtgccgtgtttcaaatattctgccacacccgttg aaat agaaaattctaatcctcctattacatataactttccatcgttaacacaagtactaacttctgattttaacgacgacata ttag taaccgttttccattttttcgtttcaagatctacccg cgatacgg aataaacatgtctattgttaatcatgccgccaataatgt atagacaattatgtaaaacatttg cattatagaattgtctatctgtattaccgactatcg tccaatattctgttctagg agagt aatgggttattgtggatatataatcagaglitttaatgactactatattatgttttataccatttcgtgtcactggctl igtagattt ggatatagttaatcccaacaatgatatagcattgcgcatagtattagtcataaacttgggatgtaaaatgttgatgata tct acatcgtttggatttttatgtatccactttaataatatcatagctgtaacatcctcatgatttacgttaacgttttcgt gggataa gatagttgtcagttcatcctttgataattttccaaattctggatcggatgtcaccgcagtaatattgttgattatttct gacatcg acgcattatatagtlitttaattccatatcttttagaaaagttaaacatccttatacaatttgtggaattaatattatg aatcata gtttttacacatagatctactacaggcggaacatcaattattatggcagcaactagtatcatttctacattgtttatgg tgatg tttatcttcttccagcgtatatagtctaatagcgattcaaacgcgtgatagtttataccattcaatataatcgcttcat ccttta gatggtgatcctgaattcgtttaaaaaaattatacggagatgccgtaataatttccttattcacttgtataatttcccc attgat agaaaatatcacgctttccattcttgaagtactataagtaattatagtataatgtaaaggtttatatattcaatatlit ttataa aaaaatcattttgacattaattcctttttaaatttccg tctatcatctatagaaacgtattctatgaatttataaaatgcttttacg tgtcctatcgtagg cgatagaaccgctaaaaag cctatcgaatttctacaaaagaatctgttatatggtatagggagag tataaaacattaaatgtccgtacttattaaagtattcagtagccaatcctaactctttcgaatacttattaatggctct tgttct gtacgaatctatttttttgaacaacggacctagtggtatatcligttctatgtatctaaaataatgtctgactagatcc gttagt ttaatatcctcagtcatcttg tctagaatggcaaatctaactgcggg tttaggctttagtttagtttttatatctacatctatgtctt tatctaacaccaaaaatataatagctaatattttattacaatcatccggatattcttctacgatctcactaactaatgt ttcttt g gttatactagtatagtcactatcg gacaaataaagaaaatcag atgatcgatgaataatacatttaaattcatcatctgt aagatttttgagatgtctcattaaaatattattagggtcagtactcattatcattcggcagctattacttattttattt ttctgtatttt attatttttcaccatatagatcaatcattagatcatcaaaatatgtttcaatcatcctaaagagtatggtgaatgactc ttccc atctaatttctgaacgttcaccaatgtctctagccactttggcactaatagcgatcattcgcttagcgtcttctatatt attaac tggttgattcaatctatctagcaatggaccgtcggacagcgtcattctcatgttcttaatcaatgtacatacatcgccg tcat ctaccaattcatccaacaacataagctttttaaaatcatcattataataggtttgatcgttgtcatttctccaaagaat atatc taataagtagagtcctcatgcttagtaatttaactattttagttaacaactattttttatgttaaatcaattagtacac cgctatg tttaatacttattcatattttagtttttaggattgagaatcaatacaaaaaattaatgcatcattaattttagaaatac ttagtttc cacgtag ttaatgaaacatttgaactcatcgtacaggacgttctcgtacaggacg taactataaaccgg tttatatttgttc aagatagatacaaatccgataactttttttacgaattctacgggatccactttaaaagtgtcataccgggttcttttta ttctttt aaacagatcaatggtgtgatgttgattaggtcttttacgaatttg atatagaatagcgttcacatatcctccataatggtca atcgccatttgttcgtatgtcataaattclitaattatatgacactgtgtattatttagttcatccttgttcatcatta ggaatctatc caaaatggcaattatactagaactataggtgcgttgtatacacatattg atgtgtctgtttatacaatccatgatatttggat

-149-ccatgctactaccttcgggtaaaattgtagcatcatataccatttctagtactttaggttcattattatccattgcaga ggac gtcatgatcgaatcctaaaaaaatatattatttttatgttattttgttaaaaataatcatcgaatacttcgtaagatac tccttc atgaacataatcagttacaaaacgtttatatgaagtaaagtatctacgatttttacaaaagtccggatgcataagtaca a agtacgcgataaacggaataataatagatttatctagtctatctttttctatagctttcatagttagatacatggtctc agaa gtaggattatgtaacatcagcttcgataaaatgactgggttatttagtcttacacattcgctcatacatgtatgaccgt taac tacaaagtctacactaaaatgattgaacaatag atagtctaccattgtttcgtattcagatagtacagcgtagtacatagc atcttcacaaattatatcattgtctaatagatatttgacgcatcttatg gatcccacttcaacagccatcttaaaatcggtag aatcatattgctttcctttatcattaataatttctaaaacatcatctctatcataaaagatacaaatattaactgtttg atccgta ataacattgctagtcgatagcaatttgttaataagatgcgctgg gctcaatgtcttaataagaagtgtaagaggactatct ccgaatttgttttgtttattaacatccgttgatggaagtaaaagatctataatgtctacattcttgactgttttagagc atacaa tatggagaggtgtatttccatcatgatctggttttgagggactaattcctagtttcatcatccatgagattgtagaagc ttttg gattgtctgacataagatgtctatgaatatgatttttgccaaatttatccactatcctggcttcgaatccgatggacat tattttt ttaaacactctttctgaaggatctgtacacgccaacaacggaccacatccttcttcatcaaccgagttgttaatcttgg ctc catactgtaccaataaatttattctctctatgacttcatcatctgttcccgagagataatatagaggtgttttattatg tttatca cacgcgtttggatctgcgccgtgcgtcagcagcatcgcgactattctattattattaattttagaagctatatgcaatg gat aatttccatcatcatccgtctcatttggagagtatcctctatgaagaagttcttcgacaaatcgttcatctagtccttt aattcc acaatacgcatgtagaatgtgataattatttccagaaggttcg atag cttgtagcatattcctaaatacatctaaatttttac tattatatttggcataaagagatagataatactcggccgacataatgttgtccattgtagtataaaaattaatatttct atttct atttctgtatatttgcaacaatttactctctataacaaatatcataacttagttcttttatgtcaagaaggcactggtt tagttcat ctataaatgtcacgccataactaccacgcatgctatactcagaattatgataaagatatttatccttggggtgtaggta at ggggattaatctttgttggatcagtctctaagttaacacatgtcacacatgatccatttatagttatatcacacgatga tgatt tatgaattgattccggaagatcg ctatcgtattligtggttccacaattcatttccatacatgttattgtcacactaatattatg a tgaactttatctagccgctgagtggtaaacaacagaacag atagtttattatctttaccaacaccctcag ccgctg ccac aaatctctgatccgtatccatgatggtcatgtttatttctagtccgtatccagtcaacactatgttagcatttctgtcg atatag ctttcactcatatgacactcaccaataatagtagaattaatgtcgtaatttacaccaatagtgagttcggcggcaaagt a ccaataccg gtaatcttgtcgaggag gacatatagtattcttgtattctaccgaatacccgagag atgcgatacaaaag agtaagactaatttgtaaaccatcttactcaaaatatgtaacaatagtacgatgcaatgagtaagacaataggaaatct atcttatatacacataattattctatcaattttaccaattagttagtgtaatgttaacaaaaatgtgggagaatctaat tagtttt tctttacacaattgacgtacatgagtctgagttccttgtttttgctaattatttcatccaatttattattcttgactat atcgagatct tttgtataggagtcagacttgtattcaacatgclittctataatcattttagctatttcggcatcatccaatagtacat tttccag attag cagaatagatattaatgtcgtatttgaacagag cctgtaacatctcaatgtctttattatctatagccaatttaatgtc cggaatgaagagaaggg aattattggtgtttgtcgacgtcatatagtcgag caagagaatcatcatatccacgtgtcc attttttatagtgatgtgaatacaactaaggagaatagccagatcaaaagtagatggtatctctgaaagaaagtagga aacaatacttacatcattaagcatgacggcatgataaaatgaagtlitccatccagttlicccatagaacatcagtctc ca

-150-atttlicttaacaaacaglittaccgtttgcatgttaccactatcaaccgcataatacaatgcggtglitcccttgtca tcaaat tgtgaatcatccagtccactgaatagcaaaatclltactattliggtatcttccaatgtggctgcctgatgtaatggaa attc attctctagaagattlitcaatgctccagcgttcaacaacgtacatactagacgcacgttattatcagctattgcataa tac aaggcactatgtccatggacatccgccttaaatgcatclitgctagagagaaagclittcagctgcttagacttccaag ta ttaattcgtgacagatccatgtctgaaacgagacgctaattagtgtatattlittcattlittataattligtcatatt gcaccag aattaataatatctctaatagatctgattagtagatacatggctatcg caaaacaacatatacacatttaataaaaataat atttattaag aaaattcagatttcacgtacccatcaatataaataaaataatgattccttacaccgtacccatattaagg a gattccaccttacccataaacaatataaatccagtaatatcatgtctg atgatgaacacaaatggtgtattaaattccagt ttlicaggagatgatctcgccgtagctaccataatagtagatgcctctgctacagttccttglicgtcgacatctatcl itgca ttctgaaacattttataaatatataatg ggtccctagtcatatgtttaaacg acg cattatctggattaaacatactaggag ccatcatttcgg ctatcgacttaatatccctcttattttcgatagaaaatttagg gagtttaag attgtacactttattccctaat tgaaacgaccaatagtctaattttgcagccgtaatagaatctgtgaaatgggtcatattatcacctattgccaggtaca ta ctaatattagcatccttatacggaaggcgtaccatatcatattcttcgtcatcgattgtgattgtatttccttgcaatt tagtaa ctacgttcatcatgggaaccglittcgtaccgtacttattagtaaaactagcattgcgtglittagtgatatcaaacgg atatt gccatatacclitaaaatatatagtattaatgattgcccatagagtattattgtcgagcatattagaatctactacatt agac ataccggatctacgttctactatagaattaattttattaaccgcatctcgtctaaagtttaatctatataggccgaatc tatga tattgttgataatacgacg gtttaatg cacacagtattatctacgaaactttgataagttagatcagtgtacgtatatttag at glittcagcttagctaatcctgatattaattctgtaaatgctggacccagatctctlittctcaaatccatagtclica ataattct attctagtattacctgatgcaggcaatagcgacataaacatagaaaacgaataaccaaacggtgagaagacaatat tatcatcttgaatattlitatacgctactataccggcattggtaaatccttgcagacgataggtagacactgaacacgt taa cgatagtatcaataacgcaatcatgattttatggtattaataattaaccttattlitatglicggtataaaaattattg atgtcta cacatcclittgtaattgacatctatatatcclittgtataatcaactctaatcactttaactlitacaglittcccta ccagtttatc cctatattcaacatatctatccatatgcatcttaacactctctg ccaagatagcttcaaagtgaggatagtcaaaaagat aaatatatagagcataatccttctcgtatactctg ccctttattacatcacccg cattggg caacg aataacaaaatg ca agcatcligttaacgggctcgtaaattgggataaaaattatglitttatatctattttattcaagagaatattcaggaa tttclitt tccggligtatctcatcgcagtatatatcatttgtacattglitcatattlittaatagtctacacclittagtaggac tagtatcgt acaattcatag ctgtattttgaattccaatcacgcataaaaatatcttccaattgttgacgaag acctaatccatcatccgg tgtaatattaatagatg ctccacatgtatccgtaaagtaatttcctgtccaatttgaggtacctatatacg ccgttttatcggtt accatatatttg gcatg gtttaccctagaatacgg aatgg gaggatcag catctggtacaataaatagctttacttctatat ttatglitttagattttagcatagcgatagatcttaaaaagtlictcatgataaacgaagatcgttgccagcaactaat caat agcttaactgacacttgtctgtctatagcggctclicttaattcatclictatataaggccaaaacaaaatattgcctg ccttc gaataaataatagggataaagttcataacagatacataaacgaatttactcgcatttctgatacatgacaataaagcg gttaaatcattgglictliccatagtacatagttgttgcggtgcagaagcaataaatacagagtgtggaacgccgctta cg ttaatactaagaggatgatctgtattataatacgacggataaaagtlittccaattatatggtagattgttaactccaa gata

-151-ccagtatacctcaaaaatttgagtgagatccgctgccaagttcctattattgaagatcgcaatacccaattctttgacc tg agttagtgatctccaatccatgttagcgcttcctaaataaatatgtgtattatcagatatccaaaattttgtatgaaga actc ctcctag gatatttgtaatatctatgtatcgtacttcaactccg gccatttgtagtctttcaacatcctttaatggtttgttagattt attgacggctactctaactcgtactcctcttttgggtaattgtacaatcttgtttaatattatcgtgccgaaattcgta cccactt catccgataaactccaataaaaagatgatatatctagtgtlittgtggtattggatagaatttccctccacatgttaaa tgta gacaaatatactttatcaaattgcatacctataggaatagtctctgtaatcactgcgattgtattatccggattcattt tatttgt taaaagaataatcctatatcacttcactctattaaaaatccaagtttctatttctttcatgactgattttttaacttca tccgtttcc ttatgaagatgatgtttggcaccttcataaatttttatttctctattacaatttgcatgttgcatgaaataatatgcac ctaaaa catcgctaatcttattgtttgttccctggagtatgagagtcggggggtgttaatcttggaaattattlitctaaccttg ttggtag ccttcaagacctgactagcaaatccagccttaattttttcatgattgattaatgggtcgtattggtatttataaacttt atccat atctctag atactgattctggacatagctttccgactggcg catttagtgtgatggttcccataagtttggcagctag caga ttcagttttgaaacagcatctgcattaactagaggagacattagaatcattgctgtaaacaagtttggattatcgtaag ag gctagctcccatggaatgacccaataagtagatttaatagttaccacgtgctgtaccaaagtcatcaatcatcattttt tca ccattacttcttccatgtccaatatgatcatgtgagaatactaaaattcctaacgatgatatgttttcagctagttcgt cataa cgtccagaatgtttaccagctccatgacttatgaatactaatgccttaggatatgtaataggtttccaatatatgtaat catt gtccagattgaacatacagtttgcactcatgattcacgttatataactatcaatattaacagttcgtttgatgatcata ttatttt tatgttttattgataattgtaaaaacatacaattaaatcaatatagaggaaggagacggctactgtcttttgtgagata gtc atggcgactaaattagattatgaggatgctgttttttactttgtggatgatgataaaatatgtagtcgcgactccatca tcga tctaatagatgaatatattacgtggagaaatcatgttatagtgtttaacaaagatattaccagttgtggaagactgtac aa ggaattgatgaagttcgatgatgtcgctatacggtactatggtattgataaaattaatgagattgtcgaagctatgagc g aaggagaccactacatcaattttacaaaagtccatgatcaggaaagtttattcgctaccataggaatatgtgctaaaat cactgaacattggggatacaaaaagatttcagaatctagattccaatcattgggaaacattacagatctgatgaccga cgataatataaacatcttgatactttttctagaaaaaaaattgaattgatgatataggggtcttcataacgcataatta ttac gttagcattctatatccgtgttaaaaaaaattatcctatcatgtatttgagagttttatatgtagcaaacatgatagct gtgat gccaataagctttagatattcacgcgtgctagtgttagggatggtattatctggtggtgaaatgtccgttatataatct aca aaataatcatcgcatatagtatgcgatagtagagtaaacatttttatcgtttctactggglicatacatcgtctaccca attc ggttataaatgaaattgtcgccaatcttacacccaaccccttgttatccattagtatagtattaacttcgttatttatg tcataa actgtaaatgattttgtagatgccatatcatacatgatattcatgtccctattataatcattactaactttatcacaat atatgtt gataatatctatatatgatctagtctttgtgggcaactgtctatacaagtcgtctaaacgttgtttactcatatagtat cgaac agccatcattacatggtcccgttccgttgatagataatcgagtatgttagtggacttgtcaaatctatataccatattt tctgg aagtggatatacatagtcgtgatcaacattattgctagcctcatcttctatatcctgtactataccattatctatatca tctaca taatctacgatattattacacataaacatcgacaacatactattgtttattatctaagtcctgttgatccaaacccttg atctc ctctatttgtactatctagagattgtacttcttccagttctggataatatatacgttgatagattagctgagctattct atctcca gtatttacattaaacgtacattttccattattaataag aatgactcctatgtttcccctataatcttcgtctattacaccgcctcc

-152-tatatcaatgccttttagggacagaccagacctaggagctattctaccatagcagaacttaggcatggacatactaata tctgtcttaattaactgtcgttctcctggagggatagtataatcgtaagcgctatataaatcatatccggcggcgtaag gtg attgcctagtaggagatttagctctgttagtttccttaacaaatctaactggtgagttaatattcatgttgaacataaa acta atattttatttcaaaattatttaccatcccatatattccatg aataagtgtg atgattgtacacttctatagtatctatatacg att cacgataaaatcctcctatcaatagcagtttattatccactatgatcaattctggattatccctcggataaataggatc atct atcagagtccatgtattgctggattcacaataaaattccg catttctaccaaccaagaataaccttctaccgaacactaa cgcgcatgatttataatgaggataataagtggatggtccaaactgccactgatcatgattgggtagcaaatattctgta g ttgtatcagtttcagaatgtcctcccattacgtatataacattgtttatggatgccactgctggattacatctaggthc agaa gactcggcatattaacccaagcagcatccccgtggaaccaacgctcaacagatgtgggatttggtagacctcctact acgtataatttattgttagcgggtatcccgctagcatacagtctggggctattcatcggaggaattggaatccaattgt ttg atatataatttaccgctatagcattgttatgtatttcattgttcatccatccaccgatgagatatactacttctccaac atgagt acttgtacacatatggaatatatctataatttgatccatgttcataggatactctatgaatggatacttgtatgatttg cgtggt tgtttatcacaatgaaatattttggtacagtctagtatccattttacattatttatacctctgggagaaagataatttg acctga ttacatttttgataaggagtagcagatttcctaatttatttcttcgctttatataccacttaatgacaaaatcaactac ataatc ctcatctggaacatttagttcatcgctttctagaataagtttcatagatagataatcaaaattgtctatgatgtcatct tccagt tccaaaaagtgtttggcaataaagtttttagtatgacataagagattggatagtccgtattctatacccatcatgtaac act cgacacaatattcctttctaaaatctcgtaag ataaagtttatacaagtgtagatgataaattctacagaggttaatatag aagcacgtaataaattgacgacgttatgactatctatatatacctttccagtatacgagtaaataactatagaagttaa a ctgtg aatgtcaaggtctagacaaacccttgtaactg gatctttatttttcgtgtatttttg acgtaaatgtgtgcgaaagtaa ggagataactttttcaatatcgtagaattgactattatattgccacctatagcatcaataattgttttgaatttcttag tcatag acaatgctaatatattcttacagtacacagtattaacaaatatcgg catttatgtttctttaaaagtcaacatctaaag aaa aatgattatcttcttgagacataactcccattttttggtattcacccacacgtttttcgaaaaaattagtttttccttc caatgat atattttccatgaaatcaaacggattggtaacattataaattthttaaatcccaattcagaaatcaatctatccgcgac ga attctatatatgttttcatcatttcacaattcattcctataagtttaactggaagagccgcagtaagaaattcttgttc aatgga taccgcatctgttataatagatctaacggtttcttcactcg gtggatg caataaatgtttaaacatcaaacatg cgaaatc gcagtgcagaccctcgtctctactaattagttcgttggaaaacgtgagtccgggcattaggccacgclitttaagccaa a atatggaagcgaatgatccagaaaagaagattccttctactgcagcaaaggcaataagtctctctccataaccggcg ctgtcatgtatccacttttgagcccaatcggccttcttttttacacaaggcatcgtttctatggcattaaagagatagt ttttttc attactatctttaacataagtatcgatcaaaagactatacatttccgaatgaatgttttcaatggccatctgaaatccg tag aaacatctagcctcggtaatctgtacttctgtacaaaatcgttccgccaaattttcattcactattccgtcactggctg caa aaaacgccaatacatgttttataaaatatttttcgtctggtgttagtttattccaatcattgatatctttagatatatc tacttcttc cactgtccaaaatgatgcctctgcctttttatacatgttccagatgtcataatattggattgggaaaataacaaatcta tttg gatttggtgcaaggatgggttccataactaaattaacaataacaataaatttlitttcagttatctatatgcctgtact tggat cttttgtacatcgatatcgccgcaatcactacaataattacaagtattattgatagcattgttattagtactatcataa ttaaat

-153-tatcgacattcatgggtgctgaataatcgttattatcatcattatcattttgtaattgtgacatcatactagataaatc gtttgc gagattgttgtgggaagcgggcatggaggatgaattatcgttattattatttaacgcctcccattcggattcacaaatg tta cgcacattcaacattttatggaaactataattttgtgaaaacagataacaagaaaactcgtcatcgttcaaatttttaa cg atagtaaaccgattaaacgtcgagctaatttctaacgctagcgactctgttggatatgggtttccagatatatatcttt tcag ttcccctacgtatctataatcatctgtaggaaatggaag atatttccatttatctactgttcctaatatcatatgtggtggtgta gtagaaccattaagcgcgaaagatgttatttcgcatcgtattttaacttcgcaataatttctggttagataacgcactc tac cagtcaagtcaatgatattagcctttacagatatattcatagtagttgtaacgatgactccatcttttagatgcgatac tcctt tgtatgtaccagaatcttcgtaccgcaaactcgatatatttaaacaagttaatgagatattaacg cgttttatg aatgatg a tatataaccag aagttttatcctcggtggctagcg ctataaccttatcattataataccaactagtgtgattaatatgtgaca cgttagtgtgggtacaaatatgtacattatcgtctacgtcgtattcg atacatccgcatacagccaacaaatataaaatg acaaatactctaacgccgttcgtacccatcttgatgcggtttaataaatgttttgatttcaatttattgtaaaaaaaga ttcgg ttttatactgttcgatattctcattgcttatattttcatctatcatctccacacagtcaaatccgtggttagcatgcac ctcatca accggtaaaagactatcggactcttctatcattataactctagaatatttaatttggtcattattaatcaagtcaatta tcttatt tttaacaaacgtgagtattttactcattttttataaaaacttttag aaatatacagactctatcgtgtgtctatatcttctttttatat ccaatgtatttatgtctgatttttcttcatttatcatatataatggtccaaattctacacgtgcttcggattcatccag atcattaa ggttcttataattgtaacatccttctcttccctcttctacatcttccttcttattcttattcttagcgtcacagaatct accacagca ggatcccatgacgagcgtcatattaaactaatccattttcaattataatatacgattagtaatgaccattaaaataaaa a atattcttcataaccggcaagaaagtgaaaagttcacattgaaactatgtcagtagtatacatcatgaaatgatgatat a tatatactctattttggtggaggattatatgatataattcgtggataatcattcttaagacacatttcttcattcgtaa atcttttc acgttaaatgagtgtccatattttgcaatttcttcatatgatggcggtgtacgtggacgaagctgctcctgttcttgtt gtagtc g ccgactgtcgtgtttg cgtttagatccctccattatcgcgattg cgtagatggagtactattatataccttgtaattaaattttt ttattaattaaacgtataaaaacgttccgtatctgtatttaagagccagatttcgtctaatagaacaaatagctacagt aa aaataactagaataattgctacacccactagaaaccacggatcgtaatacggcaatcggttttcgataataggtggaa cgtatattttatttaag gacttaacaattgtctgtaaaccacaatttgcttccg cg gatcctgtattaactatctgtaaaagca tatgttgaccgggcggagccgaacattctccgatatctaatttctgtatatctataatattattaacctccgcatacgc atta cagttcttttctagcttggataccgcactaggtacatcgtctagatctattcctatttcttcagcgatagctcttctat ccttttcc ggaagcaatgaaatcacttcaataaatgattcaaccatgagtgtgaaactaagtcgagaattactcatgcatttgttag t tattcggagcgcgcaatttttaaactgtcctataacctctcctatatgaatagcacaagtgacattagtagggatagaa tg ttgagctaatttttgtaaataactatctataaaaagattatacaaagttttaaactctttagtttccgccatttatcca gtctga gaaaatgtctctcataataaatttttccaagaaactaattgggtgaagaatggaaacctttaatctatatttatcacag tct gttttggtacacatgatgaattcttctaatgctgtactaaattcgatatctttttcgatttctggatatgtttttaata aagtatgaa caaagaaatggaaatcgtaataccagttatgttcaactttgaaattgtlitttattttcttgttaatgattccagccac ttggga aaagtcaaagtcgtttaatgccgatttaatacgttcattaaaaacaaactttttatcctttagatgaattattattggt tcattg gaatcaaaaagtaagatattatcgggtttaagatctgcgtgtaaaaagttgtcgcaacagggtagttcgtagattttaa t

-154-gtataacagagccatctgtaaaaagataaactttatgtattgtaccaaagatttaaatcctaatttgatagctaactcg gt atctactttatctgccgaatacagtgctaggggaaaaattataatatttcctclitcgtattcgtagttaglictclit tcatglic gaaaaagtgaaacatgcggttaaaatagtttataacattaatattactgttaataactgccggataaaagtgggatagt aatttcacgaatttgatactgtcctlictctcgttaaacgcctttaaaaaaactttagaagaatatctcaatgagagtt cctg accatccatagthgtatcaataatagcaacatatg aagaacccgtttatacagagtatgtaaaaatgttaatttatagttt aatcccatggcccacgcacacacgattaattlittlicatctccctttagattgligtatagaaatttgggtactgtga actcc gccgtaglitccatgggactatataattligtggcctcgaatacaaattttactacatagttatctatcttaaagacta tacca tatcctcctgtagatatgtgataaaaatcgtcgtttataggataaaatcgtttatcclittgliggaaaaaggatgaat taatg taatcattctclictatclitagtagtglitccttattaaaattcttaaaataatttaacaatctaactgacggagccc aattligg tgtaaatctaattgggacattatgttgttaaaatacaaacagtctcctaatataacagtatctgataatctatggggag ac atccattgatattcaggggatgaatcattggcaacacccatttattgtacaaaaagccccaatttacaaacgaaagtcc aggtttgatagagacaaacaattaactattligtctctglitttaatttctliggtaatgaaattattcacaatatcag tatclictt tatctaccagagattttactaacttgataaccttgg ctgtctcattcaatag ggtagtaatatttgtatgtgtgatattgatatct littgaattglitclittagaagtgattclitgatggtgccagcatacgaattacaataatgcagaaactcagttaaca tgca gg aattatagtaag ccaattccaattgttgcctgtattgtattag agtattaatatgcg caatg gtgtccttgcgtttctctg at agaatgcgagcagcgattliggcgttatcatttgacgatatttctggaatgacgaatcctglitctactaactlittgg tagg acaaagtgaaacaatcaagaag atagcttctcctcctatttgtggaag aaattgaactcctctagatgatctactgacg atagtatctccttgacagatattggaccgaattacagaagtacctggaatgtaaagccctgaaaccccctcattlitta a gcagattgttgccgtaaatcctgcactgtgaccaagatagagagctcctttggtgaatccatctctatglitcagttta acc aagaaacagtcagctggtctaaaatttccatctctatctaatacag catctaacttg atgtcaggaactatgaccggttta atgttatatgtaacattgagtaaatccttaagttcataatcatcactgtcatcagttatgtacgatccaaacaatglit ctact ggcatagtggatacgaagatgctatccatcagaatglitccctgattagtattlictatatagctattclictttaaac gattlic caaatcagtaactatglicatttlittaggagtaggacgcctagccagtatggaagaggattlictagatcctctclic aac atctttg atctcgatg gaatgcaaaaccccatagtgaaacaaccaacg ataaaaataatattglitttcactlittataatttt accatctgactcatggattcattaatatclitataagagctactaacgtataattclltataactgaactgagatatat acac cggatctatggtttccataattgagtaaatgaatg ctcggcaataactaatgg caaatgtatagaacaacgaaattata ctagagligttaaagttaatattlictatgagctgliccaataaattatttgligtaactgcgttcaagtcataaatca tcttgat actatccagtaaaccgtglitaaglictggaatattatcatcccattgtaaagcccctaattcgactatcgaatatcct gctc tgatagcaglitcaatatcgacggacgtcaatactgtaataaaggtggtagtattgtcatcatcgtgataaactacggg a atatggtcgttagtaggtacggtgactttacacaacgcgatatataactlicclittgtaccattlitaacgtagttgg gacgt cctgcag ggtattgttttgaag aaatgatatcgagaacagatttgatacgatatttgttgg attcctgattattcactataata taatctagacag atagatg attcgataaatagagaaggtatatcgttg gtaggataatacatccccattccagtattctc ggatactctattgatgacactagttaagaacatgtclictattctagaaaacgaaaacatcctacatggactcattaaa a clictaacgctcctgattgtgtctcgaatgcctcgtacaaggatttcaaggatgccatagattclitgaccaacgattt aga

-155-attgcgtttagcatctgatttttttattaaatcgaatggtcggctctctggtttgctaccccaatgataacaatagtct tgtaaa g ataaaccgcaagaaaatttatacgcatccatccaaataaccctag caccatcggatg atattaatgtattattatagat tttccatccacaattattgggccagtatactgttagcaacg gtatatcg aatagattactcatgtaacctactagaatgata gttcgtgtactagtcataatatctttaatccaatctaagaaatttaaaattagattlittacactgttaaagttaacaa aggtat tacccggatacgtggatatcatatatggcattggtccattatcagtaatagctccataaactgatacggcgatggtttt tat atgtgtttgatctaacgaggaagaaattcgcgcccacaattcatctctagatatgtatttaatatcaaacggtaacaca tc aatttcgggacgcgtatatglitctaaatttttaatccaaatataatgatgacctatatgccctattatcatactgtca actata gtacacctagagaacttacgatacatctgtttcctataatcgttaaattttacaaatctataacatgctaaaccttttg acga cagccattcattaatttctgatatggaatctgtattctcgataccgtattgttctaaagccagtgctatatctccctgt tcgtgg gaacgctttcgtataatatcgatcaacggataatctgaagtttttggagaataatatgactcatgatctatttcgtcca taa acaatctagacataggaattggaggcgatgatcttaattttgtgcaatgagtcgtcaatcctataacttctaatcttgt aat attcatcatcgacataatactatctatgttatcatcgtatattagtataccacggccttcttcatttcgtgccaaaata atatac agtcttaaataattacgcaatatctcaatagtttcataattgttagctgttttcatcaagatttgtaccctglitaaca tgatggc gttctatacgtctctattttcttttttttaaatttttaacgatttactgtggctagatacccaatctctctcaaatatt tttttagcctcg cttacaagctgtttatctatactattaaaactgacg aatccgtgattttggtaatgggttccgtcgaaatttgccgaagtgat atgaacatattcgtcgtcgactatcaacaattttgtattattctgaatagtgaaaaccttcacagatagatcattttga acac acaacgcgtctagacttctggcggttgccatagaatatacgtcgttcttatcccaattaccaactagaagtctgatctt aa ctcctctattaatggctgcttctataatggagttgtaaatgtcgggccaatagtagctattaccgtcgacacgtgtagt ggg aactatggccaaatgttcaatatctatactagtcttagccgacttgagtttatcaataactacatcggtatctagatct ctag aatatcccaataggtgttccggagaatcagtaaagaacactccacctataggattcttaatatgatacgcagtgctaac tggcaaacaacaagccgcag agcataaattcaaccatgaattttttgcgctattaaagg ctttaaaagtatcaaatcttc tacgaagatctgtggccagcgggggataatcagaatatacacctaacgttttaatcgtatgtatagatcctccagtaaa t gacgcgtttcctacataacatctttcatcatctgacacccaaaaacaaccgagtagtagtcccacattattttttttat ctat attaacggttataaaatttatatccgggcagtgactttgtagctctcccagatttcttttccctcgttcatctagcaaa actatt attttaatccctttttcagatgcctcttttagtttatcaaaaataagcgctcccctagtcgtactcagaggattacaac aaaa agatgctatgtatatatatttcttagctagagtgataatttcgttaaaacattcaaatgttgttaaatgatcggatcta aaatc catattttctggtagtgtttctaccagcctacattttgctcccgcaggtaccgatgcaaatggccacatttagttaaca taaa aacttatacatcctgttctatcaacgattctagaatatcatcg gctatatcg ctaaaattttcatcaaagtcgacatcacaa cctaactcagtcaatatattaagaagttccatgatgtcatcttcgtctatttctatatccgtatccattgtagattgtt gaccga ttatcgagtttaaatcattactaatactcaatccttcagaatacaatctgtgtttcattgtaaatttataggcggtgta tttaagt tggtagattttcaattatgtatcaatatagcaacagtagttcttgctcctccttgattctagcatcctcttcattattt tcttctacgt acataagcatgtccaatacgttagacaacacaccgacgatg gcgg ccg ccacagacacgaatatg actag accg atgaccatttaaaaacccctctctagctttcacttaaactgtatcgattattcttttagaacatgtataatataaaaac attatt ctatttcgaatttaggcttccaaaaatttttcatccgtaaaccg ataataatatatatagacttgttaatagtcggaataaat

-156-agattaatgcttaaactatcatcatctccacgattagagatacaatatttacattttttttgctgtttcgaaactttat caataca cgttaatacaaacccaggaaggagatattgaaactgaggctgttgaaaatgaaacggtgaatacaataattcagata atgtaaaatcatgattccgtattctgatgatattagaactg ctaatg gatgtcg atggtatgtatctaggagtatctattttaa caaagcatcgatttgctaatatacaattatccttttgattaattgttattttattcatattcttaaaaggtttcatatt tatcaattctt ctacattaaaaatttccatttttaatttatgtagcccccgcaatactcctcattacgtttcattttttgtctataatat ccattttgttc atctcggtacatagattatccaattgagaag cgcatttagtagttttgtacattttaagtttattgacg aatcgtcgaaaact agttatagttaacattttattatttgataccctgatattaatacccctg ccgttactattatttataactg atgtaatccacgtaa cattagaattaattatcgatagtaatgcatcgacgcttccaaaattgtctattataaactcaccgataatttttttatt gcatgtt ttcatattcattaggattatcaaatctttaatcttactacgattgtatgcgttgatattgcaagacgtcattctaaaag acgga gg atctccatcaaatgccag acaatcacgtacaaagtacatggaaataggttttgttctattgcg catcatagatttatat agaacacccgtagaaatactaatttgttttactctataaaatactaatgcatctatttcatcgttttgtataacgtctt tccaag tgtcaaattccaaatttttttcattgatagtaccaaattcttctatctctttaactacttgcatagataggtaattaca gtgatgc ctacatg ccgttttttgaaactg aatagatgcgtctagaagcgatgctacg ctagtcacaatcaccactttcatatttaga atatatgtatgtaaaaatatagtagaatttcattttgttthttctatgctataaatgaattctcattttgcatctgctc atactccgt tttatatcaataccaaagaaggaagatatctggttctaaaagccgttaaagtatgcgatgttagaactgtag aatgcg a aggaagtaaagcttcctgcgtactcaaagtagataaaccctcatcgcccgcgtgtgagagaagaccttcgtccccgt ccagatgcgagagaatgaataaccctggaaaacaagttccgtttatgaggacggacatgctacaaaatatgttcgcg gctaatcgcgacaacgtggcgtcgag acttttg aactaaaatacaattatatccttttcgatattaataaatccgtgtcgtc caggthtttatctctttcagtatgtgaatagataggtattttatctctattcatcatcgaatttaagagatccgataaa cattgtt tgtattctccagatgtcag catctgatacaacaatatatgtgcacataaacctctg gcacttatttcatgtaccttccccttat cactaaggagaatagtatttgagaaatatgtatacatgatattatcatgaattagatatacagaatttgtaacactctc ga aatcacacgatgtgtcg gcgttaagatctaatatatcactcgataacacattttcatctag atacactag acattttttaaa gctaaaatagtctttagtagtgacagtaactatgcgattattttcatcgatgatacatttcatcggcatattattacgc ttacc atcaaagactataccatgtgtatatctaacgtattctagcatggttgccatacgcgcattaaactlitcaggatctttg gata gatcttccaatctatctatttgagaaaacatttttatcatgttcaatagttgaaacgtcggatccactatatagatatt atctat aaagattttaggaactacgttcatggtatcctggcgaatattaaaactatcaatgatatgattatcgttttcatctttt atcacc atatagtttctaagatatgggattttacttaatataatattatttcccgtgataaattttattagaaaggccaaatcta taaga aaagttctagaattagtctg aagaatatctatatcgccgtaccgtatatttggattaattag atatagagaatatg atccgt aacatatacaacttttattatggcgtctaagatattcttccatcaacttattaacatttttgactagggaagatacatt atgac gtcccattacttttgccttgtctattactgcgacgttcatag aatttag catatctcttgccaattcttccattgatgttacattata agaaattttagatgaaattacatttggagctttaatagtaagaactcctaatatgtccgtgtatgtggtcactaataca gatt gtagttctataatcgtaaataatttacctatattatatgtttgagtctgtttagaaaagtagctaagtatacgatcttt tatttctg atgcagatgtattaacatcggaaaaaaatctttttttattctthttactaaagatacaaatatgtctttgttaaaaaca gttattt tttgaatatttctagcttgtaattttaacatatgatattcgttcacactaggtactctgcctaaataggtttctataat ctttaatgt

-157-aatattaggaagagtattctgatcaggattcctattcattttgaggatttaaaactctgattattgtctaatatggtct ctacgc aaactlittcacagagcgatagagtlittgataactcgtlittcttaagaaatataaaactactgtctccagagctcgc tctat clittattttatttaattcgatacaaactcctgatactgglicagaaagtaattcattaattlicagtcctttatagaa gatattta atatagataatacaaaattlicaglicttgatatcgatctgattgatcctagaactagatatattaataacgtgctcat tagg cagtttatg gcagcttg ataattagatatagtatattccagttcatatttattagataccgcattg cccagattttgatattctat gaattcctctgaaaataaatccaaaataactaaacattctattlittgtggattagtgtactctcttccctctatcatg licact actggtgtccacgatgataaatatctagagggaatataatatagtccataggatgccaatctagcaatgtcgaataact gtaatttgattcttcgttclicattatgaattgattcttgaggtataaacctaacacaaattatattattagactlitc gtatgtaat gtclitcatgttataaglitttaatcctggaatagaatctattttaatgaggclittaaacgcagaglictccaacgag tcaaa gcataatactctgligtlittcttatatacgatgttacgattlicttclitgaatggaatagglitttgaattagttta taattacaac ataatagataaggaagtgtgcaaatagtacgcggaaaaaacataatagctcccctglittcatccatgglittaagtaa atgatcactggclictttagtcaatggatattcgaacattaaccgtttcatcatcattggacagaatccatatttctta atgta aagagtgatcaaatcattgtglitattgtaccatcttgligtaaatgtgtattcggttatcggatctgctcctlittct attaaagt atcgatgtcgatctcgtctaagaattcaactatatcgacatatttcatttgtatacacataaccattactaacgtagaa tgta taggaag agatgtaacgg gaacagggtttgttg attcgcaaactattctaatacataattclictgttaatacgtcttgcac gtaatctattatagatg ccaagatatctatataattattttgtaag atgatgttaactatgtgatctatataagtagtgtaataa ttcatgtatttcgatatatgliccaactctgtclitgtgatgtctagtttcgtaatatctatagcatcctcaaaaaata tattcgca tatattcccaagtclicaglictatcttctaaaaaatcttcaacgtatggaatataataatctattttacctclictga tatcatta atgatatagtlittgacactatclictgtcaattgattcttattcactatatctaagaaacggatagcgtccctaggac gaact actgccattaatatctctattatagclictggacataattcatctattataccagaattaatgggaactattccgtatc tatcta acataglittaagaaagtcagaatctaagacctgatglicatatattgglicatacatgaaatgatctctattgatgat agtg actatttcattctctg aaaattggtaactcattctatatatgctttccttgttgatgaaggatag aatatactcaatagaatttgt accaacaaactglictcttatgaatcgtatatcatcatctgaaataatcatgtaag gcatacatttaacaattagagacttg tctcctgttatcaatatactattcligtgataatttatgtgtgaggcaaatttgtccacgttclitaattligttatag tagatatca aatccaatggagctacagttcliggcttaaacagatatagtlittctggaacgaattctacaacattattataaaggac ttt gggtagataagtgggatgaaatcctattttaattaatgcgatagccligtcctcgtgcagatatccaaacgclittgtg ata gtatggcattcattgtctagaaacgctctacgaatatctgtgacagatatcatctttagagaatatactagtcgcgtta ata gtactacaatttgtattlittaatctatctcaataaaaaaattaatatgtatgattcaatgtataactaaactactaac tgttatt gataactagaatcagaatctaatgatgacgtaaccaagaagtttatctactgccaatttagctgcattattlitagcat ctc glitagattliccatctgccttatcgaatactcttccgtcgatgtctacacaggcataaaatgtaggagagttactagg ccc cactgattcaatacgaaaagaccaatctctcctagtaatttggcagtactcattaataacggtgacagggttagcacct t tccaatcaataattlitttagccggaataacatcatcaaaagacttatgatcctctctcattgattlitcgcgggatac atcat ctattatgacgtcag ccatagcatcagcatccg gcttatccgcctccgttgtcataaaccaacgaggag gaatatcgtc ggagctgtacaccatagcactacgttgaagatcgtacagagctttattaacttctcgclictccatattaagttgtcta gtta

-158-gttgtgcagcagtagctccttcgattccaatggttttaatagcctcacacacaatctctgcgttagaacgctcgtcgat ata gattttagacatttttagagagaactaacgcaatcagtaataaaactaatttattttatcattttttttattcatcatc ctctggtg gttcgtcgtttctatcgaatgtagctctgattaacccgtcatctataggtgatgctggttctggagattctggaggaga tgga ttattatctggaagaatctctgttatttccttgttttcatgtatcgattgcgttgtaacattaagattgcgaaatgctc taaatttg ggaggcttaaagtgttgtttgcaatctctacacgcgtgtctaactagtggaggttcgtcagcggctctagtttgaatca tca tcggcgtagtattcctacttttacagttaggacacggtgtattgtatttctcgtcgagaacgttaaaataatcgttgta actca catcctttattttatctatattgtattctactcctttcttaatgcattttataccgaataagagatagcgaaggaattc ttlitcggt gccgctagtacccttaatcatatcacatagtgttttatattccaaatttgtggcaatagacggtttatttctatacgat agtttgt ttctggaatcctttgagtattctataccaatattattctttgattcgaatttagtttcttcgatattagattttgtatt acctatattctt gatgtagtactttgatgattlitccatggcccattctattaagtcttccaagttggcatcatccacatattgtgatagt aattctc ggatatcagtagcggttaccgccattgatgthgttcattggatgagtaactactaatgtatacattttccatttataac actta tgtattaactttgttcatttatattttttcattattatgttgatattaacaaaagtgaatatatatatgttaataattg tattgtggttat acggctacaattttataattagtgaaagtcagtgtccgatgatcaatgacgatagctttactctgaaaagaaagtatca a atcgatagtgcggagtcaacaataaaaatggataagaagaggacaaagtttcagaatagagccaaaatggtaaa agaaataaatcagacaataagagcagcacaaactcattacgagacattgaaactaggatacataaaatttaagag aatgattaggactactactctagaagatatagcaccatctattccaaataatcagaaaacttataaactattctcggac a tttcagccatcggcaaagcatcacggaatccaagtaagatggtatatgctctgctgctttacatgtttcccaatttgtt tgg agatgatcatagattcattcgttatagaatgcatccaatgagtaaaatcaaacacaagatcttctctcctttcaaactt aat cttattagaatattagtggaagaaagattctataataatgaatgcagatctaataaatggagaataattggaacacaag ttgataaaatgttgatagctg aatctg ataaatatacaatagatgcaag gtataacctaaaacccatgtatag aatcaa gggaaaatctgaagaagataccctctttatcaaacagatggtagaacaatgtgtgacatcccaggaattggtggaaa aagtgttgaagatactgtttagagatttgttcaagagtggagaatacaaagcgtacagatacgatgatgatgtagaaa atggatttattggattggatacactaaaattaaacattgttcatgatatagttgaaccatgtatgcctglicgtaggcc agtg gctaagatactgtgtaaagaaatggtaaataaatactttgagaatccgctacatattattggtaaaaatcttcaagagt g cattgactligttagtgaataggcatttcatctttctccaatactaattcaaattgttaaattaataatggatagtata aatagtt attagtgataaaatagtaaaaataattattagaataagagtgtagtatcatagataactctcttctataaaaatggatt ttat tcgtagaaagtatcttatatacacagtagaaaataatatagatlitttaaaggatgatacattaagtaaagtaaacaat ttt accctcaatcatgtactagctctcaagtatctagttagcaattttcctcaacatgttattactaaggatgtattagcta atacc aatttttttgttttcatacatatggtacgatgttgtaaagtgtacgaagcggttttacgacacgcatttgatgcaccca cgttgt acgttaaagcattgactaagaattatttatcgtttagtaacacaatacaatcgtacaaggaaaccgtgcataaactaac acaagatgaaaaatttttagaggttgccaaatacatggacgaattaggagaacttataggcgtaaattatgacttagtt c ttaatccattatttcacggaggggaacccatcaaagatatggaaatcatttttttaaaactgtttaagaaaacagactt ca aagttgttaaaaaattaagtgttataagattacttatttgggcttacctaagcaagaaagatacaggcatagagtttgc g gataatg atagacaagatatatatactctatttcaacaaactggtag aatcgtccatag caatctaacagaaacgttta

-159-gagattatatctttcccggagataagactagctattgggtgtggttaaacgaaagtatagctaatgatgcggatattgt tct taatagacacg ccattaccatgtatgataaaattcttagttatatatactctgag ataaaacaag gacgcgttaataaaa acatgcttaagttagtttatatclitgagcctgaaaaagatatcagagaacttctgctagaaatcatatatgatattcc tgg agatatcctatctattattgatg caaaaaacg acg attggaaaaaatattttattagtttttataaagctaattttattaacgg taatacatttattagtgatagaacgtttaacgaggacttattcagagttgttgttcaaatagatcccgaatatttcgat aatg aacgaattatgtctttattctctacgagtgctgcggacattaaacgatttgatgagttagatattaataacagttatat atcta atataatttatgaggtgaacgatatcacattagatacaatggatgatatgaagaagtgtcaaatctttaacgaggatac gtcgtattatgttaaggaatacaatacatacctgtttttgcacgagtcggatcccatggtcatagagaacggaatacta a agaaactgtcatctataaaatccaagagtagacggctgaacttglitagcaaaaacattttaaaatattatttagacgg a caattggctcgtctaggtcttgtgttagatgattataaaggagacttgttagttaaaatgataaaccatcttaagtctg tgga ggatgtatccgcattcgttcgattttctacagataaaaaccctagtattcttccatcgctaatcaaaactattttagct agtta taatatttccatcatcgtcttatttcaaaggtttttaagagataatctatatcatgtagaagaattcttggataaaagc atcca tctaaccaagacggataagaaatatatacttcaattgataagacacggtagatcatagaacagaccaaatatattatt aataatttgtatatacatagatataattatcacatattaaaaattcacacatttttgataaatgggaactgctgcaaca attc agactcccaccaaattaatgaataaagaaaatgcagaaatgattttggaaaaaattgttgatcatatagttatgtatat t agtgacgaatcaagtgattcagaaaataatcctgaatatattgattttcgtaacagatacgaagactatagatctctca tt ataaaaagtgatcacgagtttgtaaagctatgtaaaaatcatgcagagaaaagttctccagaaacgcaacaaatgat tatcaaacacatatacgaacaatatcttattccagtatctgaagtactattaaaacctataatgtccatgggtgacata att acatataacgg atgtaaagacaatgaatg gatgctagaacaactctctaccctaaactttaacaatctccgcacatgg aactcatgtagcataggcaatgtaacgcgtctgttttatacattttttagttatctgatgaaagataaactaaatatat aagt ataatcccattctaatactttaacctgatgtattagcatcttattagaatattaacctaactaaaagacataacataaa aac tcattacatagttgataaaaagcggtaggatataaatattatggctgccaccgttccgcgttttgacgacgtgtacaaa a atgcacaaagaagaattctagatcaagaaacattttttagtagaggtctaagtagaccgttaatgaaaaacacatatct atttgataattacgcgtatggatggataccagaaactgcaatttggagtagtagatacgcaaacttagatgcaagtgac tattatcccatttcgttgggattacttaaaaagttcgagtttctcatgtctctatataaaggtcctattccagtatacg aagaa aaagtaaatactgaattcattgctaatggatcgttctctggtagatacgtatcatatcttcgaaagttttctgctcttc caaca aacgagtttattagttttttgttactgacttccattccaatctataatatcttgttctggtttaaaaatactcagtttg atattacta aacacacattattcagatacgtctatacagataatgccaaacacctggcgttggctaggtatatgcatcaaacaggag actataagcctttgtttagtcgtctcaaagagaattatatatttaccggtcccgttccaataggtatcaaagatataaa tca ccctaatcttagtagagcaagaagtccatccgattatgagacattag ctaatattagtactatattgtactttaccaagtat gatccggtattaatgtttttattgttttacgtacctgggtattcaattactacaaaaattactccagccgtagaatatc taatgg ataaactgaatctaacaaagagcgacgtacaactgttgtaaattattttatgcttcgtaaaatgtaggttttgaaccaa ac attctttcaaagaatgagatgcataaaactttattatccaatagattgactatttcggacgtcaatcgtttaaagtaaa cttc gtaaaatattctttgatcactgccgagtttaaaacttctatcgataattgtttcatatgttttaatatttacaagtttt ttggtccat

-160-ggtacattagccggacaaatatatgcaaaataatatcgttctccaagttctatagtttctggattatttttattatatt cagtaa ccaaatacatattagggttatctgcggatttataatttgagtgatgcattcgactcaacataaataattctagaggaga cg atctactatcaaattcggatcgtaaatctgtttctaaagaacggagaatatctatacatacctgattagaattcatccg tcc ttcagacaacatctcagacagtctggtcttgtatgtcttaatcatattcttatgaaacttggaaacatctcttctagtt tcacta gtacctttattaattctctcaggtacagattttgaattcgacgatgccgagtatttcatcgttgtatatttcttcttcg attgcata atcagattcttatataccgcctcaaactctattttaaaattattaaacaatactctattattaatcagtcgttctaact cctttgct atttctatggacttatctacatcttgactgtctatctctgtaaacacgg agtcggtatctccatacacgctacgaaaacgaa atctgtaatctataggcaacgatgttttcacaatcggattaatatctctatcgtccatataaaatggattacttaatgg attg g caaaccgtaacataccgttagataactctg ctccatttagtaccgattctagatacaagatcattctacg tcctatggat gtgcaactcttagccgaagcgtatgagtatagagcactatttctaaatcccatcagaccatatactgagttggctacta tc ttgtacgtatattgcatggaatcatagatggccttttcagttgaactggtagcctgttttaacatctttttatatctgg ctctctct gccaaaaatgttcttaatagtctaggaatggttccttctatcgatctatcgaaaattgctatttcagagatgaggttcg gta g tctaggttcacaatgaaccgtaatatatctaggaggtggatatttctg aagcaagagctgattatttatttcttcttccaatc tattggtactaacaacgacaccgactaatgtttccggagatagatttccaaagatacacacattaggatacagactgtt ataatcaaagattaatacattattactaaacatlitttgttttggagcaaataccttaccgccttcataaggaaacttt tgtttt gtttctgatctaactaagatagttttagtttccaacaatagctttaacagtggacccttgatgactgtactcgctctat attcg aataccatggattgaggaagcacatatgttgacgcacccgcgtctgtttttgtttctactccataatactcccacaaat act gacacaaacaagcatcatgaatacagtatctagccatatctaaagctatgtttagattataatccttatacatctgagc ta aatcaacgtcatcctttccgaaagataatttatatgtatcattaggtaaagtaggacataatagtacgactttaaatcc att ttcccaaatatctttacgaattactttacatataatatcctcatcaacagtcacataattacctgtggttaaaaccttt gcaaa tgcagcggctttgcctttcgcgtccgtagtatcgtcaccgatgaacgtcatttctctaactcctctatttaatacttta cccatg caactgaacgcgttcttggatatagaatccaatttgtacgaatccaattlitcagatttttgaatgaatgaatatagat cga aaaatatagttccattattgttattaacgtgaaacgtagtattggccatgccgcctactcccttatgactagactgatt tctct cataaatacagagatgtacagcttcctttttgtccggagatctaaagataatcttctctcctgttaataactctagacg atta gtaatatatctcagatcaaagttatgtccgttaaaggtaacgacatagtcgaacgttagttccaacaattgtttagcta ttc gtaacaaaactatttcagaacataaaactagttctcgttcgtaatccatttccattagtgactgtatcctcaaacatcc tcta tcgacggcttcttgtatttcctgttccgttaacatctcttcattaatgagcgtaaacaataatcgtttaccacttaaat cgatat aacagtaacttgtatgcgagattgggttaataaatacagaaggaaacttcttatcgaagtgacactctatatctagaaa t aagtacgatcttgggatatcgaatctaggtatttttttagcgaaacagttacgtggatcgtcacaatgataacatccat tgt taatctttgtcaaatattgctcgtccaacgagtaacatccgtctggag atatcccgttagaaatataaaaccaactaatat tgagaaattcatccatggtggcattttgtatgctgcgtttctttggctcttctatcaaccacatatctgcgacggagca ttttct atctttaatatctagattataacttattgtctcgtcaatgtctatagttctcatctttcccaacggcctcgcattaaat ggagga ggagacaatgactgatatatttcgtccgtcactacgtaataaaagtaatgaggaaatcgtataaatacggtctcaccat t tcgacatctggatttcagatataaaaatctgttttcaccgtgactttcaaaccaattaatgcaccgaacatccatttat aga

-161-atttagaaatatattttcatttaaatgaatcccaaacattggggaagagccgtatggaccattatttttatagtacttt cgca agcgggtttagacggcaacatagaagcgtgtaaacgaaaactatatactatagttagcactcttccatgtcctgcatgt agacggcacgcgactatcg ctatagaggacaataatg tcatgtctagcgatg atctgaattatatttattattttttcatcag attatttaacaatttg gcatctgatcccaaatacg cgatcgatgtgacaaag gttaaccctttataaacttaacccattata aaacttatgattagtcacgactgaaataaccgcgtgattattttttggtataattctacacggcatggtttctgtgact atga attcaacccccgttacattagtgaaatctttaacaaacagcaagggttcgtcaaagacataaaactcattgtttacaat c gaaatagaccccctatcacacttaaaataaaaaatatccttatcctttaccaccaaataaaattctgattggtcaatgt g aatgtattcacttaacagttccacaaatttatttattaactccgagg cacatacatcgtcg gtattttttatggcaaactttact cttccagcatccgtttctaaaaaaatattaacgagttccatttatatcatccaatattattgaaatgacgttgatggac aaat gatacaaataagaaggtacggtacctttgtccaccatctcctccaattcatgctctattttgtcattaactttaatgta tgaa aacagtacgccacatgcttccatgacagtgtgtaacactttggatacaaaatgtttgacattagtataattgttcaaga ct gtcaatctataatagatagtagctataatatattctatgatggtattgaagaagatgacaaccttggcatattgatcat ttaa cacagacatggtatcaacagatagcttgaatgaaagagaatcagtaattggaataagcgtcttctcgatggagtgtcc gtataccaacatgtctgatattttgatgtattccattaaattatttagttttttctttttattctcgttaaacagcatt tctgtcaacgg accccaacatcgttgaccgattaagttttgattg atttttccgtg taaggcgtatctagtcagatcgtatagcctatccaata atccatcgtctgtgtgtagatcacatcgtacactttttaattctctatagaagagcgacagacatctggagcaattaca ga cagcaatttctttattctctacagatgtaagatacttgaagacattcctatgatgatgcagaattttggataacacggt attg atggtatctgttaccataattcctttgatggctgatagtgtcagagcacaagatttccaatctttgacaatttttagca ccatt atctttgttttgatatctatatcagacagcatggtgcgtctgacaacacaaggattaagacggaaagatgaaatgattc t ctcaacatcttcaatggataccttgctattttttctggcattatctatatgtgcgagaatatcctctagagaatcagta tcctttt tgatgatagtggatctcaatgacatgggacgtctaaaccttcttattctatcaccagattgcatggtgatttgtcttct ttctttt atcataatgtaatctctaaattcatcggcaaattgtctatatctaaaatcataatatgagatgtttacctctacaaata tctgtt cgtccaatgttagagtatttacatcagttttgtattccaaattaaacatggcaacggatttaattttatattcctctat taagtcc tcgtcgataataacagaatgtagataatcatttaatccatcgtacatggttggaagatgctcgttgacaaaatctttaa ttg tcttgatgaaggtgggactatatctaacatcttgattaataaaatttataacattgtccataggatactttgtaactag ttttat acacatctcttcatcggtaagtttagacagaatatcgtgaacag gtggtatattatattcatcagatatacg aagaacaa tgtccaaatctatattgtttaatatattatatagatgtagtg tagctcctacag gaatatctttaactaagtcaatgatttcatc aaccgttagatctattttaaagttaatcatataggcattgatlittaaaaggtatgtagccttgactacattctcatta attaac cattccaagtcactgtgtgtaagaagattatattctatcataagcttgactacatttggtcccgataccattaaagaat tctt atgatataaggaaacagattttaggtactcatctactctacaagaattttggagagccttaacgatatcagtgacgttt att atttcaggaggaaaaaacctaacattgagaatatcggaattaatagcttccagatacagtgattttggcaatagtccgt gtaatccataatccagtaacacgagctggtgcttgctagacaccttttcaatgtttaatttttttgaaataagctttga taaag ccttcctcgcaaattccggatacatgaacatgtcggcgacatgattaagtattgttttttcattatttttatattttct caacaag ttctcaataccccaatagatgatagaatatcacccaatg cgtccatgttgtctatttccaacaggtcgctatatccaccaa

-162-tagaagtlitcccaaaaaagattctaggaacagttctaccaccagtaatttgttcaaaatagtcacgcaattcattttc gg gtttaaattctttaatatcgacaatttcatacgctcctcttttgaaactaaacttatttagaatatccagtgcatttct acaaaa aggacatgtatacttgacaaaaattgtcactttgttattggccaacctttgttgtacaaattcctcggccattttaata tttaag tgatataaaactatctcgacttatttaactctttagtcgagatatatggacgcagatagctatatgatagccaactaca ga ag gcaaacgctataaaaaacataattacgacgag catatttataaatatttttattcagcattacttgatatagtaatatta ggcacagtcaaacattcaaccactctcgatacattaactctctcattttctttaacaaattctgcaatatcttcgtaaa aag attcttgaaacttlitagaatatctatcgactctagatgaaatagcgttcgtcaacatactatgttttgtatacataaa ggcgc ccattttaacagtttctagtg acaaaatgctagcg atcctaggatcctttagaatcacatagattgacgattcgtctctctta gtaactctagtaaaataatcatacaatctagtacgcgaaataatattatccttgacttgaggagatctaaacaatctag tt ttgagaacatcgataagttcatcgggaatgacatacatactatctttaatagaactcttttcatccagttgaatggatt cgtc cttaaccaactgattaatgagatcttctattttatcattttccagatgatatgtatgtccattaaagttaaattgtgta gcgcttct ttttagtctagcagccaatactttaacatcactaatatcgatatacaaaggagatgatttatctatggtattaagaatt cgttt ttcgacatctgtcaaaaccaattcctlittgcctgtatcatccagttttccatcctttgtaaagaaattattttctact agactatt aataagactgataaggattcctccataattgcacaatccaaactttttcacaaaactagactttacaagatctacagga atgcgtacttcaggtttcttagcttgtgatlitttcttttgtggacattlicttgtgaccaactcatctaccatttcat tgattttagca gtgaaataagctttcaatgcacgggcactgatactattgaaaacgagttgatcttcaaattccgccatttaagttcacc a aacaactlitaaatacaaatatatcaatagtagtagaataagaactataaaaaaaataataattaaccaataccaacc ccaacaaccggtattattagttgatgtgactgttttctcatcacttagaacagatttaacaatttctataaagtctgtc aaatc atcttccggagaccccataaatacaccaaatatagcg gcg tacaacttatccatttatacattgaatattggcttttctttat cgctatcttcatcatattcatcatcaatatcaacaag tcccagattacgagccagatcttcttctacattttcagtcattg ata cacgttcactatctccagagagtccgataacgttagccaccacttctctatcaatgattagtttcttgagtgcgaatgt aatt tttgtttccgttccggatctatagaaaactacaggtgtgataattgccttggccaattgtctttctcttttactgagtg attctagt tcaccttctatagatctgagaatggatgattctccagtcgaaacatattctaccatggctccgtttaatttgttgatga agat ggattcatccttaaatgttttctctgtaatagtttccaccgaaagactatgcaaagaatttggaatgcgttccttgtgc ttaat g tttccatagacggcttctagaagttgatacaacataggactagccg cggtaacttttatttttagaaagtatccatcgctt ctatcttgtttagatttatttttataaagtttagtctctccttccaacataataaaagtggaagtcatttgactagata aactatc agtaagttttatag agatagacgaacaattag cgtattgagaagcatttagtgtaacgtattcgatacattttgcattag at ttactaatcgattttgcatactctataacacccgcacaagtctgtagagaatcgctagatgcagtaggtcttggtgaag ttt caactctcttcttgattaccttactcatgattaaacctaaataattgtactttgtaatataatgatatatattttcact ttatctcatt tgagaataaaaatgtttttgtttaaccactgcatgatgtacagatttcggaatcacaaaccaccggtggttttatttta tcctt gtccaatgtgaattgaatgggagcgg atgcg ggtttcgtacgtagatagtacattcccgtttttagaccgagactccatc cgtaaaaatgcatactcgttagtttgg aataactcgg atctg ctatatggatattcatagattgactttgatcgatgaaggc tcccctgtctgcagccatttttatgatcgtcttttgtggaatttcccaaatagttttataaactcgcttaatatcttct ggaaggtt tgtattctgaatggatccaccatctgccataatcctattcttgatctcatcattccataattttctctcggttaaaact ctaagg

-163-ag atgcggattaactacttgaaattctccag acaatactctccgagtgtaaatattactggtatacggttccaccg actca ttatttcccaaaatttgagcagttgatgcagtcggcataggtgccaccaataaactatttctaagaccgtatgttctga tttt atcttttagaggttcccaattccaaagatccgacggtacaacattccaaagatcatattgtagaataccgttactggcg t acgatcctacatatgtatcgtatggtccttccttctcagctagttcacaactcgcctctaatgcaccgtaataaatggt ttcg aagatcttcttatttagatcttgtgcttccaggctatcaaatggataatttaagagaataaacgcgtccgctaatcctt gaa caccaataccgataggtctatgtctcttattagagatttcagcttctggaataggataataattaatatctataatttt attga gatttctgacaattactttgaccacatccttcagtttg agaaaatcaaatcgcccatctattacaaacatgttcaaggcaa cagatgccagattacaaacggctacctcattagcatccgcatattgtattatctcagtgcaaagattactacacttgat ag ttcctaaattttgttgattactctttttgttacacgcatccttataaagaatgaatggagtaccagtttcaatctgaga ttctata atcgctttccagacgactcgagcctttattatagatttgtatctcctttctctttcgtatagtgtatacaatcgttcga actcgtct ccccaaacattgtccaatccaggacattcatccggacacatcaacgaccactctccgtcatccttcactcgtttcataa a g agatcaggaatccaaagagctataaatagatctctg gttctatgttcctcg tttcctgtattctttttaagatcgaggaacg ccataatatcagaatgccacggttccaagtatatggccataactccaggccgtttgtttcctccctgatctatgtatct agc ggtgttattataaactctcaacattggaataataccgtttgatataccattggtaccggagatatagcttccactggca cg aatattactaattgatagacctattccccctgccattttagagattaatgcgcatcgttttaacgtgtcatagataccc tctat gctatcatcgatcatgttaagtagaaaacagctagacatttggtgacgactagttcccgcattaaataaggtaggaga agcgtg cg taaaccatttttcagaaagtagattg tacgtctcaatagctgagtctatatcccattgatgaattcctactgcg acacgcattaacatgtgctgaggtctttcaacgatcttgttgtttattttcaacaagtaggatlittccaaagttttaa aacca aaatagttgtatgaaaagtctcgttcgtaaataataaccgagttgagtttatccttatatttgttaactatatccatgg tgata cttgaaataatcggagaatgtttcccatttttaggattaacatagttgaataaatcctccatcacttcactaaatagtt tttttgt ttccttgtgtagatttgatacggctattctggcggctagaatggcataatccggatgttgtgtagtacaagtggctgct atttc ggctgccagagtgtccaattctaccgttgttactccattatatattccttgaataaccttcatagctattttaatagga tctata tgatccgtgtttaagccataacataattttctaatacgagacgtgattttatcaaacatgacattttccttgtatccat ttcgttt aatgacaaacatttttgttggtgtaataaaaaaattatttaacttttcattaatagggatttgacgtacgtagcgtaca aaat gattgttcctggtatatagataaagagtcctatatatttgaaaatcgttacggctcgattaaactttaatgattgcata gtga atatatcattaggatttaactccttgactatcagggcggcaccagaaattaccatcaaaagcattaatacagttatgcc t atcgcagttagaacggttatagcatccaccatttatatctaaaaattagatcaaagaatatgtgacaaagtcctagttg t atattgagaattgacaaaacaatgtttcttacatattttttttttattagtaaccgacttaatagtaggaactggaaaa ctaga cttgattattctataagtatagatacccttccaaataatattctctttg ataaaagttccagaaaatgtagaattttttaaaaa gttatcttttgctattaccaagattg tgtttagacgcttattattaatatgagtgatg aaatccacaccgcctctagatatcg c ctttatttccacattagatggtaaatccaatagtgaaactatctttttaggaatgtatggactcgcgtttagaggagtg aac gtcttgggcgtcggaaaggatgattcgtcaaacgaataaacaatttcacaaatggatgttaatgtattagtaggaaatt tt ttgacgctagtggaattgaaaattctaatg gatgatg ttctacctatttcatccgataacatgttaatttccgacaccaacg gttttaatatttcgatgatatacggtagtctctctttcg gacttatatagcttattccacaatacgagtcattatatactccaaa

-164-aaacaaaataactagtataaaatctgtatcgaatgggaaaaacgaaattatcgacataggtatagaatccggaacat tgaacgtattaatacttaattctlittctgtggtaagtaccgataggttattgacattgtatggttttaaatattctat aacttgag a cttg atag atatta gtg atg aattg aaa attatttttatcacca cgtg tgtttcag g atcatcg tcg acg cccgtcaa cca accgaacggagtaaaataaatatcattaatatatgctctagatattagtatttttatcaatcctttgattatcatclic tcgtag g cgaatgattccatgatcaagagtgatttaagaacatcctccg gagtattaatgggcttagtaaacagtccatcgttg ca ataataaaagttatccaagttaaaggatattatgcattcgtttaaagatatcacctcatctgacggagacaattttlig gta ggttttagagactttgaagctacttgtttaacaaagttattcatcgtcgtttactattctatttaattttgtagttaat ttatcacata tcacatta attg actttttg gtccatttttccata cg tttatattcttttaatcctg cgttatccgtttccgttatatccag tg atag at cgtgcaggttaaatagaatgctcttaaataatgtcatttttttatccgctaaaaatttaaagaatgtataaactttttt caaag atttaaaacttttaggtggtgtcctagtacacaatatcataaacaaactaataaacatcccgcattcagattccaacag c tg attaa cttccacattaata cag cctattttcg ctcca aatg ta cattcg aaa aatctg aataaaa catcaatgtcg ca a tttgtattatccaatacagaatgtttgtgattcgtgttaaaaccatcgg agaaggaatagaaataaaaattattatagtg gt ggaattcagttggaatattgcctccggagtcataaaaggatactaaacattgttttttatcataaattacacatttcca atg agacaaataacaaaatccaaacattacaaatctagaggtagaactlitaattttgtctttaagtatatacgataagata tg tttattcataaacgcgtcaaatttttcatgaatcgctaaggagtttaagaatctcatgtcaaattgtcctatataatcc acttc ggatccataagcaaactgagagactaagttcttaatacttcgattgctcatccaggctcctctctcaggctctattttc atct tg acg acctttg g attttcaccagtatgtattccttttttttctag acacta aataaa atatttaaaatataatattaatgtacta aaacttatatattattaatttatctaactaaagttagtaaattatatatataattttataattaatttaattttactaa ttttatttagtg tctagaaaaaaa [0077] An example of sVAC fragment 2 (F2, 66679 bp in length) (SEQ ID NO:
17):
thttttctagacactaaataaaatatttaaaatataatattaatgtactaaaacttatatattattaatttatctaact aaagtta gtaaattatatatataattttataattaatttaattttactaattttatttagtgtctagaaaaaaaccccctgccatt ttagagatt aatgcgcatcgttttaacgtgtcatagataccctctatgctatcatcgatcatgttaagtagaaaacagctagacattt ggt gacgactagttcccgcattaaataaggtaggagaagcgtgcgtaaaccatttttcagaaagtagattgtacgtctcaat a g ctg agtctatatcccattg atg aattcctactg cg a cacg cattaacatgtg ctg ag gtctttcaacg atcttgttgtttat tttcaacaagtaggatttttccaaagttttaaaaccaaaatagttgtatgaaaagtctcgttcgtaaataataaccgag ttg agtttatccttatatttgttaactatatccatggtgatacttgaaataatcggagaatgtttcccatttttaggattaa catagtt gaataaatcctccatcacttcactaaatagtttttttgtttccttgtgtagatttgatacggctattctggcggctaga atggca taatccggatgttgtgtagtacaagtggctgctatttcggctgccagagtgtccaattctaccgttgttactccattat atatt ccttgaataaccttcatagctattttaataggatctatatgatccgtgtttaagccataacataattttctaatacgag acgtg attttatcaaacatgacattttccttgtatccatttcgtttaatg acaaacatttttgttggtgtaataaaaaaattatttaactttt cattaatagggatttgacgtacgtagcgtacaaaatgattgttcctggtatatagataaagagtcctatatatttgaaa atc

-165-gttacggctcgattaaactttaatgattgcatagtgaatatatcattaggatttaactccttgactatcagggcggcac cag aaattaccatcaaaagcattaatacagttatgcctatcg cagttagaacggttatagcatccaccatttatatctaaaaat tagatcaaagaatatgtgacaaagtcctagttgtatattgagaattgacaaaacaatgtttcttacatatttttttlit attagt aaccgacttaatagtaggaactggaaaactagacttgattattctataagtatagatacccttccaaataatattctct ttg ataaaagttccagaaaatgtagaattttttaaaaagttatcttttg ctattaccaagattgtgtttagacgcttattattaatat gagtgatgaaatccacaccgcctctagatatcgcctttatttccacattagatggtaaatccaatagtgaaactatctt ttt aggaatgtatggactcgcgtttagaggagtgaacgtcttgggcgtcggaaaggatgattcgtcaaacgaataaacaa tttcacaaatggatgttaatgtattagtaggaaattttttgacgctagtggaattgaaaattctaatggatgatgttct accta tttcatccgataacatgttaatttccgacaccaacggttttaatatttcgatgatatacggtagtctctctttcggact tatata gcttattccacaatacgagtcattatatactccaaaaaacaaaataactagtataaaatctgtatcgaatgggaaaaac gaaattatcgacataggtatagaatccggaacattgaacgtattaatacttaattctttttctgtggtaagtaccgata ggtt attgacattgtatggttttaaatattctataacttgagacttgatagatattagtgatgaattgaaaattatttttatc accacgt gtgtttcaggatcatcgtcgacgcccgtcaaccaaccgaacggagtaaaataaatatcattaatatatgctctagatat t agtatttttatcaatcctttgattatcatcttctcgtaggcgaatgattccatgatcaagagtgatttaagaacatcct ccgga gtattaatgggcttagtaaacagtccatcgttgcaataataaaagttatccaagttaaaggatattatgcattcgttta aag atatcacctcatctgacggagacaattttttggtaggttttagag actttgaagctacttgtttaacaaagttattcatcgtcgt ttactattctatttaattttgtagttaatttatcacatatcacattaattgactttttggtccatttttccatacgttt atattcttttaatc ctgcgttatccgtttccgttatatccagtgatagatcgtgcaggttaaatagaatgctcttaaataatgtcattttttt atccgct aaaaatttaaagaatgtataaacttttttcaaagatttaaaacttttaggtggtgtcctagtacacaatatcataaaca aac taataaacatcccgcattcagattccaacagctgattaacttccacattaatacagcctattttcgctccaaatgtaca ttc gaaaaatctgaataaaacatcaatgtcgcaatttgtattatccaatacagaatgtttgtgattcgtgttaaaaccatcg ga gaaggaatagaaataaaaattattatagtggtggaattcagttggaatattgcctccggagtcataaaaggatactaa acattgttttttatcataaattacacatttccaatgagacaaataacaaaatccaaacattacaaatctagaggtagaa ct tttaattttgtctttaagtatatacgataagatatgtttattcataaacgcgtcaaatttttcatgaatcgctaaggag tttaaga atctcatgtcaaattgtcctatataatccacttcggatccataagcaaactgagagactaagttcttaatacttcgatt gctc atccagg ctcctctctcaggctctattttcatcttgacg acctttggattttcaccagtatgtattcctttacgtg ataaatcatc g attttcaaatccatttgtgagaagtctatcgccttag atactttttcccgtagtcgaggtttaaagaaatacgctaacggta tactagtaggtaactcaaaaacatcatatatag aatggtaacgcgtctttaactcgtcggttaactctttcttttgatcgagtt cgtcgctactattgggtctgctcaggtgccccgactctactagttccaacatcataccgataggaatacaagacacttt g ccggcggttgtagatttatcatatttttccactacatatccgttacaatttgttaaaaatttagatacatctatattgc tacataa tccagctagtgaatatatatg acataataaattggtaaatcctagttctg gtattttactaattactaaatctgtatatctttcc atttatcatggaaaagaatttaccagatatcttcttttttccaaactgcgttaatgtattctcttacaaatattcacaa gatgaa ttcagtaatatgagtaaaacggaacgtgatagtlictcattggccgtgtttccagttataaaacatagatggcataacg c acacgttgtaaaacataaaggaatatacaaagttagtacagaagcacgtggaaaaaaagtatctcctccatcactag

-166-gaaaacccgcacacataaacctaaccgcgaagcaatatatatacagtg aacacacaataag ctttg aatgttatagt tttctaaaatgtataacaaatacagaaatcaattcgttcgatgagtatatattaagaggactattagaagctggtaata gt ttacagatattttccaattccgtaggtaaacgaacagatactataggtgtactagggaataagtatccatttagcaaaa tt ccattggcctcattaactcctaaagcacaacgagagatattttcagcgtggatttctcatagacctgtagttttaactg ga ggaactggagtgggtaagacgtcacaggtacccaagttattgctttggtttaattatttatttggtggattctctactc tagat aaaatcactaactttcacgaaagaccagtcattctatctcttcctag gatagctttagttagattgcatagcaataccatttt aaaatcattgggatttaaggtactagatggatctcctatttctttacggtacggatctataccggaagaattaataaac aa acaaccaaaaaaatatggaattgtattttctacccataagttatctctaacaaaactatttagttatggcactcttatt atag acgaagttcatgagcatgatcaaataggagatattattatag cagtagcgag aaagcatcatacgaaaatagattcta tgtttttaatgactgccacgttagaggatgaccgagaacggctaaaagtattlitacctaatcccgcatttatacatat tcct ggagatacactgtttaaaattagcgaggtatttattcataataagataaatccatcttccagaatggcatacatagaag a agaaaagagaaatttagttactgctatacagatgtatactcctcctgatggatcatccggtatagtctligtggcatcc gtt gcacagtgtcacgaatataaatcatatttagaaaaaagattaccgtatgatatgtatattattcatggtaaggtcttag ata tagacgaaatattagaaaaagtgtattcatcacctaatgtatcgataattatttctactccttatttggaatccagcgt tacta tacgcaatgttacacacatttatgatatgggtaaagtttttgtccccgctccttttggaggatcgcaagaatttatttc taaat ctatgagagatcaacgaaaaggaagagtaggaagagttaatcctggtacatacgtctatttctatgatctgtcttatat g aagtctatacagcgaatagattcagaatttctacataattatatattgtacgctaataagtttaatctaacactccccg aag atttgtttataatccctacaaatttggatattctatggcgtacaaag gaatatatagactcgttcgatattagtacagaaac atggaataaattattatccaattattatatgaagatgatagagtatgctaaactttatgtactaagtcctattctcgct gagg agttggataactttgagaggacgggagaattaactagtattgtacgagaagccattttatctctaaatttacgaattaa ga ttttaaattttaaacataaagatgatgatacgtatatacacttttgtaaaatattattcggtgtctataacggaacaaa cgct actatatattatcatagacctctaacgggatatatgaatatgatttcagatactatatttgttcctgtagataataact aaaa atcaaactctaatgaccacatctttttttagagatgaaaaattttctacatctccttttgtagacacgactaaacattt tgcaa aaaaaagtttattagtgtttagataatcgtatacttcatcagtgtagatagtaaatgtgaacaaataaaaggtattctt act caatagattggtaaattccatagaatatattaatcctttcttcttgagatcccacatcatttcaaccagagacgtttta tcca atgatttacctcgtactataccacatacaaaactagattttgcagtgacgtcgtacctggtattcctaccaaacaaaat ttt acttttagttclittagaaaattctaaggtagaatctctatttgccaatatgtcatctatggaattaccactagcaaaa aatg atagaaatatatattgatacatcgcagctg gttttg atctactatactttaaaaacgaatcagattccataattgcctgtata tcatcagctgaaaaactatgttttacacgtattccttcggcatttctttttaatgatatatcligtttagacaatgata aagttatc atgtccatgagagacgcgtctccgtatcgtataaatatttcattag atgttagacgcttcattaggggtatacttctataagg tttcttaatcagtccatcattggttgcgtcaagaactactatcggatgligttgggtatctctagtgttacacatggcc ttacta aagtttgggtaaataactatgatatctctattaattatagatgcatatatttcattcgtcaaggatattagtatcgact tgctat cgtcattaatacgtgtaatgtaatcatataaatcatgcgatagccaaggaaaattcaaatagatgttcatcatataatc gt cgctataattcatattaatacgttgacattgactaatttgtaatatagcctcgccacgaagaaagctctcgtattcagl itca

-167-tcgataaaggataccgttaaatataactggttgccgatagtctcatagtctattaagtggtaagtttcgtacaaataca ga atccctaaaatattatctaatgttggattaatctttaccataactgtataaaatggagacggagtcataactattttac cgttt gtacttactggaatagacgaaggaataatctccggacatgctggtaaagacccaaatgtctgtttgaagaaatccaat gttccaggtcctaatctcttaacaaaaattacgatattcgatcccgatatcctttgcattctatttaccagcatatcac gaac tatattaag attatctatcatgtctattctcccaccgttatataaatcg cctccgctaag aaacgttagtatatccatacaatg gaatacttcatttctaaaatagtattcgttttctaattctttaatgtgaaatcgtatactagaaagggaaaaattatct ttgagtt ttccgttagaaaagaaccacgaaactaatgttctgattgcgtccgattccgttgctgaattaatggatttacaccaaaa a ctcatataacttctagatgtagaagcattcgctaaaaaattagtagaatcaaaggatataagtagatgttccaacaagt g agcaattcccaagatttcatctatatcattctcgaatccg aaattag aaattcccaagtagatatcctttttcatccgatcg ttgatgaaaatacgaactttattcggtaagacaatcatttactaaggagtaaaataggaagtaatgttcgtatgtcgtt atc atcgtataaattaaaggtgtgthtttaccattaagtgacattataattttaccaatattggaattataatataggtgta tttgcg cactcgcgacggttgatgcatcggtaaatatagctgtatctaatgttctagtcggtatttcatcatttcgctgtctaat aatag cgttttctctatctgtttccattacagctgcctgaagtttattggtcggataatatgtaaaataataagaaatacatac gaat aacaaaaataaaataagatataataaagatgccatttagagatctaattttgttcaacttgtccaaattcctacttaca g a agatgagg aatcgttggagatagtgtcttccttatgtagagg atttgaaatatcttatgatgacttgataacttactttccag ataggaaataccataaatatatttctaaagtatttgaacatgtagatttatcggaggaattaagtatggaattccatga ta caactttgcgagatttagtctatcttagattgtacaagtattccaagtgtatacggccgtgttataaattaggagataa tcta aaaggcatagttgttataaaggacaggaatatttatattagggaagcaaatgatgacttgatagaatatctcctcaagg aatacactcctcagatttatacatattctaatgag cgcgtccccataactggttcaaaattaattctttgtggattttctcaag ttacatttatggcgtatacaacgtcg catataacaacaaataaaaaggtagatgttctcgtttccaaaaaatgtatag at gaactagtcgatccaataaattatcaaatacttcaaaatttatttgataaaggaagcggaacaataaacaaaatactc aggaagatattttattcggtaacaggtggccaaactccataggtagctttttctatttcggattttagaatttccaaat tcacc agcgatttatctgttttggtgaaatccaaggatttattaatgtccacaaatgccatttgttttgtctgtggattgtatt tgaaaat ggaaacgatgtagttagatagatgcgctgcgaagtttcctattagggttccgcgcttcacgtcacccagcatacttgaa t caccatcctttaaaaaaaatgataagatatcaacatg gagtatatcatactcggattttaattcttctactgcatcactg ac attttcacaaatactacaatacggtttaccgaaaataatcagtacgttcttcatttatgggtatcaaaaacttaaaatc gtta ctgctggaaaataaatcactgacg atattagatg ataatttatacaaagtatacaatggaatatttgtggatacaatgag tatttatatagccgtcgccaattgtgtcagaaacttagaag agttaactacggtattcataaaatacgtaaacggatgg g taaaaaagggagggcatgtaaccctttttatcgatagaggaagtataaaaattaaacaagacgttagagacaagag acgtaaatattctaaattaaccaaggacagaaaaatgctagaattagaaaagtgtacatccgaaatacaaaatgtta ccggatttatg gaagaagaaataaaggcagaaatg caattaaaaatcgataaactcacatttcaaatatatttatctg a ttctgataacataaaaatatcattgaatgagatactaacacatttcaacaataatgagaatgttacattattttattgt gatg aacgagacgcagaattcgttatgtgtctcgaggctaaaacacatttctctaccacaggagaatggccgttgataataa gtaccgatcaggatactatgctatttgcatctgctgataatcatcctaagatgataaaaaacttaactcaactgtttaa ata

-168-tgttccatctgcagaggataactatttagcaaaattaacggcgttagtgaatggatgtgatttctttcctggactctat ggg gcatctataacacccaacaacttaaacaaaatacaattgtttagtgattttacaatcgataatatagtcactagtttgg ca attaaaaattattatagaaagactaactctaccgtagacgtgcgtaatattgttacgtttataaacgattacgctaatt tag acgatgtctactcgtatattcctccttgtcaatgcactglicaagaatttatattttccgcattagatgaaaaatggaa tgaat ttaaatcatcttatttagaaagcgtgccgttaccctgccaattaatgtatgcgttagaaccacgcaaggagattgatgt ttc agaagttaaaactttatcatcttatatagatttcgaaaatactaaatcagatatcgatgttataaaatctatatcctcg atctt cggatattctaacgaaaactgtaacacgatagtattcggcatctataaggataatttactactgagtataaatagttca ttt tactttaacgatagtctgttaataaccaatactaaaagtg ataatataataaatataggttactagattaaaaatggtgttc caactcgtgtgctctacgtgcggcaaagatatttctcacgaacgatataaattgattatacgaaaaaaatcattaaagg atgtactcgtcagtgtaaagaacgaatgttgtaggttaaaattatctacacaaatagaacctcaacgtaacttaacagt gcaacctctattggatataaactaatatggatccggttaattttatcaagacatatgcgcctagaggttctattatttt tatta attataccatgtcattaacaagtcatttgaatccatcgatagaaaaacatgtgggtatttattatggtacgttattatc ggaa cacttggtagttgaatcaacatatagaaaaggagttcgaatagtcccattggatagttlitttgaaggatatcttagtg caa aagtatacatgttagagaatattcaagttatgaaaatagcagctgatacgtcattaactttattgggtattccgtatgg attt ggtcatgatagaatgtattgttttaaattggtagctgactgttataaaaatgccggtattgatacatcgtctaaacgaa tatt aggtaaagatatttttctgagccaaaacttcacagacgataatagatggataaagatatatgattctaataatttaaca ttt tggcaaattgattaccttaaagggtgagttaatatgcataactactcctccgttgttttttccctcgttctttttctta acgttgttt gccatcactctcataatgtaaagatattctaaaatggtaaacttttgcatatcggacgcagaaattggtataaatglig ta attgtattatttcccgtcaatggactagtcacagctccatcagttttatatcctttagagtatttctcactcgtgtcta acattcta gagcattccatgatctgtttatcgttgatattggccggaaagatagattttttatttlitattatattactattggcaa ttgtagata taacttctggtaaatatttttctaccttttcaatctcttctattttcaagccggctatatattctgctatattgttgct agtatcaata ccttttctggctaagaagtcatatgtggtattcactatatcagttttaactggtagttccattagcctttccacttctg cagaat aatcagaaattggttctttaccagaaaatccagctactataataggctcaccgatgatcattggcaaaatcctatattg ta ccagattaatgagagcatatttcatttccaataattctgctagttcttgagacattgatttatttgatgaatctagttg gttctct agatactctaccatttctgccgcatacaataacttgttagataaaatcagggttatcaaagtgtttagcgtggctagaa ta gtgggcttgcatgtattaaagaatgcggtagtatgagtaaaccgttttaacgaattatatagtctccagaaatctgtgg cg ttacatacatgagccgaatgacatcgaagattgtccaatatttttaatagctgctctttgtccattatttctatatttg actcgc aacaattgtagataccattaatcaccgattcctttttcgatgccggacaatagcacaattgtttagctttggactctat gtatt cagaattaatagatatatctcttaatacagattgcactatacattttgaaactatgtcaaaaattgtagaacgacgctg ttc tgcagccatttaactttaaataatttacaaaaatttaaaatgag catccgtataaaaatcgataaactg cgccaaattgt ggcatatttttcagagttcagtgaagaagtatctataaatgtagactcgacggatgagttaatgtatatttttgccgcc ttgg g egg atctgtaaacatttggg ccattatacctctcagtgcatcagtgttctaccgcg gagccgaaaatattgtgtttaatct tcctgtgtccaaggtaaaatcgtgtttgtgtagttttcacaatgatg ccatcatagatatagaacctgatctggaaaataat ctagtaaaactttctagttatcatgtagtaagtgtcgattgtaataaggaactgatgcctattaggacagatactacta tttg

-169-tctaagtatagatcaaaagaaatcttacgtgtttaattttcacaagtatgaagaaaaatgttgtggtagaaccgtcatt cat ttagaatggttgttgggctttatcaagtgtattagtcagcatcagcatttggctattatgtttaaagatgacaatatta ttatga agactcctggtaatactgatgcattttccagggaatattctatgactgaatgttctcaagaactacaaaagttttcttt caaa atagctatctcgtctctcaacaaactacgaggattcaaaaagagagtcaatgtttttgaaactagaatcgtaatggata atgacgataacattttaggaatgttgttttcggatagagttcaatcctttaagatcaacatctttatggcgtlittaga ttaata ctttcaatgagataaatatgggtggcggagtaagtgttgagctccctaaacgggatccgcctccgggagtacccactg atgagatgttattaaacgtggataaaatgcatgacgtgatagctcccgctaagcttttagaatatgtgcatataggacc a ctagcaaaagataaagaggataaagtaaagaaaagatatccagagtttagattagtcaacacaggacccggtggt ctttcggcattgttaagacaatcgtataatggaaccgcacccaattgctgtcgcactlitaatcgtactcattattgga aga aggatggaaagatatcagataagtatgaagagggtgcagtattagaatcgtgttggccagacgttcacgacaccgg aaaatgcgatgttgatttattcgactggtgtcagggggatacgttcgatagaaacatatgccatcagtggatcggttca g cctttaataggagtaatagaactgtagagggtcaacaatcgttaataaatctgtataataagatgcaaacattatgtag t aaagatgctagtgtaccaatatgtgaatcatttttg catcatttacgcgcacacaatacagaagatagcaaagag atg atcgattatattctaagacaacagtctgcggactttaaacagaaatatatgagatgtagttatcccactagagataagt t ag aagagtcattaaaatatgcggaacctcgagaatgttgggatccag agtgttcgaatgccaatgttaatttcttgctaa cacgtaattataataatttaggactttgcaatattgtacgatgtaatactagcgtgaacaacttacagatggataaaac tt cctcattaagattgtcatgtggattaagcaatagtgatagattttctactglicccgtcaatagagcaaaagtagttca aca taatattaaacactcgttcgacctaaaattgcatttgatcagtttattatctctcttggtaatatggatactaattgta gctattt aaatgggtgccgcggcaagcatacagacgacggtgaatacactcagcgaacgtatctcgtctaaattagaacaag aagcg aatgctagtgctcaaacaaaatgtgatatagaaatcgg aaatttttatatccgacaaaaccatggatgtaacc tcactgttaaaaatatgtgctctgcggacgcggatgctcagttggatgctgtgttatcagccgctacagaaacatatag t ggattaacaccggaacaaaaagcatacgtgccagctatgtttactgctgcgttaaacattcagacgagtgtaaacact gttgttagagattttgaaaattatgtgaaacagacttgtaattctagcgcggtcgtcgataacaaattaaagatacaaa a cgtaatcatagatgaatgttacggagccccagg atctccaacaaatttggaatttattaatacag gatctag caaagga aattgtgccattaaggcgttgatgcaattgacgactaaggccactactcaaatagcacctaaacaagttgctggtaca ggagttcagttttatatgattgttatcggtgttataatattggcagcgttgtttatgtactatgccaagcgtatgttgt tcacatc caccaatgataaaatcaaacttattttagccaataaggaaaacgtccattggactacttacatggacacattctttaga a cttctccgatggttattgctaccacggatatgcaaaactgaaaatatattgataatattttaatagattaacatggaag ttat cactgatcgtctagacgatatagtgaaacaaaatatagcggatgaaaaatttgtagattttgttatacacggtctagag c atcaatgtcctgctatacttcgaccattaattaggttgtttattg atatactattatttgttatagtaatttatatttttacg gtacgt ctagtaagtagaaattatcaaatgttgttggcgttggtgg cgctagtcatcacattaactattttttattactttatactataata gtactagactg acttctaacaaacatctcacctg ccataaataaatgcttgatattaaagtcttctatttctaacactattcc atctgtggaaaataatactctgacattatcgctaattgacacatcggtgagtgatatgcctataaagtaataatcttct ttg ggcacatataccagtgtaccaggttctaacaacctatttactggtgctcctatagcatactttttctttaccttgagaa tatcc

-170-atcgtttgcttggtcaatagcgatatgtgattttttatcaaccactcgaaaaagtaattggagtgttcatatcctctac gggct attgtctcatggccgtgtatgaaatttaagtaacacgactgtg gtagatttgttctatagagccggttgccgcaaatagat agaactaccaatatgtctgtacaaatgttaaacattaattgattaacagaaaaaacaatgttcgttctgggaatagaaa ccagatcaaaacaaaattcgttag aatatatgccacgtttatacattgaatataaaataactacagtttg aaaaataac agtatcatttaaacatttaacttg cggg gttaatctcacaactttactgtttttgaactgttcaaaatatag catagatccgtg agaaatacgtttagccgcctttaatagaggaaatcccaccgcctttctggatctcaccaacgacgatagttctgaccag caactcatttcttcatcatccacctgttttaacatataataggcaggagatagatatccgtcattgcaatattccttct cgtag gcacacaatctaatattgataaaatctccattctcttctctgcatttattatcttgtttcggtggctgattaggctgta gtcttggt ttaggctttggtatatcgttgttgaatctattttggtcattaaatctttcatttcttcctggtatattlitatcacctc gtttggttggatt tttgtctatattatcgtttgtaacatcggtacgggtattcatttatcacaaaaaaaacttctctaaatgagtctactgc tagaa aacctcatcgaagaagataccatattttttg cag gaagtatatctgagtatgatg atttacaaatggttattgccggcgca aaatccaaatttccaagatctatgctttctatttttaatatagtacctagaacgatgtcaaaatatgagttggagttga ttcat aacgaaaatatcacaggagcaatgtttaccacaatgtataatataagaaacaatttgggtctaggagatgataaacta actattgaagccattgaaaactatttcttggatcctaacaatgaagttatgcctcttattattaataatacggatatga ctgc cgtcattcctaaaaaaagtggtaggag aaagaataagaacatg gttatcttccgtcaaggatcatcacctatcttgtgta ttttcgaaactcgtaaaaagattaatatttataaagaaaatatgg aatccgcgtcgactgagtatacacctatcgg aga caacaaggctttgatatctaaatatgcgggaattaatatcctaaatgtgtattctccttccacatccataagattgaat gcc atttacggattcaccaataaaaataaactagagaaacttagtactaataaggaactagaatcgtatagttctagccctc t tcaagaacccattaggttaaatgattttctggg actattggaatgtgttaaaaagaatattcctctaacagatattccg ac aaaggattgattactataaatggagaatgttcctaatgtatactttaatcctgtgtttatagagcccacgtttaaacat tcttt attaagtgthataaacacagattaatagttttatttgaagtattcgttgtattcattctaatatatgtattttttagat ctgaattaa atatgttcttcatgcctaaacgaaaaatacccgatcctattgatagattacgacgtgctaatctagcgtgtgaagacga t aaattaatgatctatggattaccatggatgacaactcaaacatctgcgttatcaataaatagtaaaccgatagtgtata a agattgtgcaaagcttttgcgatcaataaatggatcacaaccagtatctcttaacgatgttcttcgcagatgatgattc attt tttaagtatttggctagtcaagatgatgaatcttcattatctgatatattgcaaatcactcaatatctagactttctgt tattatta ttgatccaatcaaaaaataaattagaagccgtgggtcattgttatgaatctctttcagaggaatacagacaattgacaa aattcacagactttcaagattttaaaaaactgtttaacaaggtccctattgttacagatggaagggtcaaacttaataa a ggatatttgttcgactttgtgattagtttgatgcgattcaaaaaagaatcctctctagctaccaccgcaatagatcctg ttag atacatagatcctcgtcgcaatatcgcattttctaacgtgatggatatattaaagtcgaataaagtgaacaataattaa tt ctttattgtcatcatgaacggcggacatattcagttgataatcggccccatgttttcaggtaaaagtacagaattaatt aga cgagttagacgttatcaaatagctcaatataaatgcgtgactataaaatattctaacgataatagatacggaacggga ctatggacgcatgataagaataattttgaagcattggaagcaactaaactatgtgatgtcttggaatcaattacagatt tc tccgtgataggtatcgatgaaggacagttctttccagacattgttgaattctgtgagcgtatggcaaacgaaggaaaaa tagttatagtagccgcactcgatgggacatttcaacgtaaaccgtttaataatattttgaatcttattccattatctga aatgg

-171-tggtaaaactaactgctgtgtgtatgaaatgctttaaggaggcttccttttctaaacgattgggtgaggaaaccgagat a gaaataataggaggtaatgatatgtatcaatcggtgtgtagaaagtgttacatcgactcataatattatattttttatc taaa aaactaaaaataaacattgattaaattttaatataatacttaaaaatg gatgttgtgtcgttagataaaccgtttatgtatttt gaggaaattgataatgagttagattacgaaccagaaagtgcaaatgaggtcgcaaaaaaactgccgtatcaagga cagttaaaactattactaggagaattattttttcttagtaagttacagcgacacggtatattagatggtgccaccgtag tgt atataggatctg ctcccggtacacatatacgttatttgag agatcatttctataatttaggagtg atcatcaaatggatgct aattgacggccgccatcatgatcctattttaaatggattgcgtgatgtgactctagtgactcggttcgttgatgaggaa tat ctacgatccatcaaaaaacaactgcatccttctaagattattttaatttctgatgtgagatccaaacgaggaggaaatg a acctagtacggcggatttactaagtaattacgctctacaaaatgtcatgattagtattttaaaccccgtggcgtctagt ctt aaatggagatgcccgtttccagatcaatggatcaaggacttttatatcccacacggtaataaaatgttacaaccttttg ct ccttcatattcagctgaaatgagattattaagtatttataccggtgagaacatgagactgactcgagttaccaaatcag a cgctgtaaattatgaaaaaaagatgtactaccttaataagatcgtccgtaacaaagtagttgttaactttgattatcct aat caggaatatgactattttcacatgtactttatgctgaggaccgtgtactgcaataaaacatttcctactactaaagcaa ag gtactatttctacaacaatctatatttcgtttcttaaatattccaacaacatcaactgaaaaagttagtcatgaaccaa tac aacgtaaaatatctagcaaaaattctatgtctaaaaacagaaatagcaagagatccgtacgcagtaataaatagaa acgtactactgagatatactaccgatatagagtataatgatttagttactttaataaccgttagacataaaattgattc tatg aaaactgtgtttcaggtatttaacgaatcatccataaattatactccggttgatgatgattatggagaaccaatcatta taa catcgtatcttcaaaaaggtcataacaagtttcctgtaaattttctatacatagatgtggtaatatctgacttatttcc tagcttt gttagactagatactacagaaactaatatagttaatagtgtactacaaacaggcgatggtaaaaagactcttcgtcttc c caaaatgttagagacggaaatagttgtcaagattctctatcgccctaatataccattaaaaattgttagatttttccgc aat aacatggtaactggagtagagatagccgatagatctgttatttcagtcgctgattaatcaattagtagagatgagataa g aacattataataatcaataatatatcttatatctcgtttag aaaaatg ctaatattaaaatagctaacgctagtaatccaat cggaagccatttgatatctataatagggtatctaatttcctgattcagatagcggacagctatattctcggtagctact cgtt tggaatcacaaacattatttacatctaatttactatctgtaatggaaacgtttcccaatgaaatggtacaatccgatac att g cattttgttatatttttttttaaagaggctggtaacaacgcatcg cttcgtttacatggctcgtaccaacaataatagggtaa tcttgtatctattcctatccgtactatgcttttatcaggataaatacatttacatcgtatatcgtctttgttagcatca cagaatg cataaatttgttcgtccgtcatgataaaaatttaaagtgtaaatataactattatttttatagttgtaataaaaaggga aattt gattgtataccttcggttctttaaaagaaactgacttgataaaaatg gctgtaatctctaaggttacgtatagtctatatgat caaaaagagattaatgctacagatattatcattagtcatgttaaaaatgacgacgatatcggtaccgttaaagatggta gactaggtgctatggatggggcattatgtaagacttgtgggaaaacggaattggaatgtttcggtcactggggtaaagt aagtatttataaaactcatatagttaagcctgaatttatttcagaaattattcgtttactgaatcatatatgtattcac tgcgga ttattgcgttcacgagaaccgtattccgacgatattaacctaaaagagttatcgggacacgctcttaggagattaaagg ataaaatattatccaagaaaaagtcatgttggaacagtgaatgtatgcaaccgtatcaaaaaattactttttcaaagaa aaaggtttglitcgtcaacaagttggatgatattaacgttcctaattctctcatctatcaaaagttaatttctattcat gaaaa

-172-gttttggccattattagaaattcatcaatatccagctaacttattttatacagactactttcccatccctccgttgatt attagac cggctattaglitttggatagatagtatacccaaagaaaccaatgaattaacttacttattaggtatgatcgttaagaa ttgt aacttgaatgctgatgaacaggttatccagaaggcggtaatagaatacgatgatattaaaattatttctaataacactt c cagtatcaatttatcatatattacatccggcaaaaataatatgattagaagttatatcgtcgcccgacgaaaagatcag a cggctagatctgtaattggtcccagtacatctatcaccgttaatgaggtaggaatgcccgcatatattagaaatacact t acagaaaagatatttgttaatgcctttacagtggataaagttaaacaactattagcatcaaaccaagttaaattttact tta ataaacgattaaaccaattaacaagaatacgccaaggaaagtttatcaaaaataaaatacatttattgcctggtgattg ggtag aagtagctgttcaagaatatacaagtattatttttggaag acag ccgtctctacatagatacaacgtcatcgcttc atctatcagagctaccgaaggagatactatcaaaatatctcccggaattgccaactctcaaaatgctgatttcgacgga gatgaagaatggatgatattagaacaaaatcctaaagctgtaattgaacaaagtattcttatgtatccgacgacgttac t caaacacgatattcatggagcccccgtttatggatctattcaagatgaaatcgtagcagcgtattcattgtttaggata ca agatctttgtttagatgaagtattgaacatcttggggaaatatggaagagagttcgatcctaaaggtaaatgtaaattc a gcggtaaagatatctatacttacttgataggtgaaaag attaattatccgggtctcttaaaggatggtgaaattattgcaa acgacgtagatagtaattttgttgtggctatgaggcatctgtcattggctggactcttatccgatcataagtcgaacgt gga aggtatcaactttattatcaagtcatcttatgtttttaagagatatctatctatttacggttttggggtgacattcaaa g atctg a gaccaaattcgacgttcactaataaattggaggccatcaacgtagaaaaaatagaacttatcaaagaagcatacgc caaatatctcaacgatgtaagagacgggaaaatagttccattatctaaagctttagaggcggactatgtggaatccat gttatccaacttgacaaatcttaatatccgagagatagaagaacatatgagacaaacgctgatagatgatccagata ataacctcctgaaaatggccaaagcgggttataaagtaaatcctacagaactaatgtatattctaggtacgtatggaca acaaaggattgatggtgaaccag cag agactcgagtattg ggtagagtcttaccttactatcttccagactctaag gat ccagaaggaagaggttacattcttaattctttaacaaaaggattaacaggttctcaatattacttttcgatgctggttg caa gatctcaatctactgatatcgtctgtgaaacatcacgtaccggaacactggctagaaaaatcattaaaaagatggagg atatggtggtcgacggatacggacaagtagttataggtaatacgctcatcaagtacgccgccaattataccaaaattct aggctcagtatgtaaacctgtagatcttatctatccagatgagtccatgacttggtatttggaaattagtgctctgtgg aat aaaataaaacag ggattcgtttactctcagaaacagaaacttg caaagaagacattggcgccgtttaatttcctagtatt cgtcaaacccaccactgaggataatgctattaaggttaaggatctgtacgatatgattcataacgtcattgatgatgtg a gagagaaatacttctttacggtatctaatatagattttatg gagtatatattcttgacgcatcttaatccttctagaattagaat tacaaaagaaacggctatcactatctttgaaaagttctatgaaaaactcaattatactctaggtggtggaactcctatt gg aattatttctgcacaggtattgtctgagaagtttacacaacaagccctgtccagttttcacactactgaaaaaagtggt gc cgtcaaacaaaaacttggtttcaacgagtttaataacttgactaatttg agtaagaataagaccgaaattatcactctg g tatccgatgatatctctaaacttcaatctgttaagattaatttcgaatttgtatgtttgggagaattaaatccagacat cactct tcgaaaagaaacagataggtatgtagtagatataatagtcaatagattatacatcaagagagcagaaattaccgaat tagtcgtcgaatatatgattgaacgattcatctcctttagcgtcattgtaaaggaatggggtatggaaacattcattga gg acgaggataatattagatttactgtctatctaaatttcgttg aaccag aggaattgaatcttagtaagtttatgatggttcttc

-173-cgggggcagccaacaagggaaagattagtaaattcaagattcctatctctgattatacgggttatgacgacttcaatca aacaaaaaagctcaataagatgactgtagaactcatgaatctaaaagaattaggttctttcgatttggaaaacgtcaa cgtgtatcctggagtatggaatacatacgatatcttcggtatcgag gccgctcgtgaatacttgtgcgaagccatgttaa acacctatggagaagggttcgattatctgtatcagccttgtgatcttctcgctagtttactatgtgctagttacgaacc aga atcagtgaataaattcaagttcggcgcagctagtactcttaagagagctacgttcggagacaataaagcattgttaaac gcggctcttcataaaaagtcagaacctattaacgataatagtagctgccactlitttagcaaggtccctaatataggaa c tggatattacaaatactttatcgacttgggtcttctcatgagaatg gaaaggaaactatctg ataagatatcttctcaaaa gatcaaggaaatggaagaaacagaagacttttaattcttatcaataacatatttttctatgatctgtcttttaaacgat ggat tttccacaaatg cgcctctcaagtccctcatagaatgatacacgtataaaaaatatag cataggcaatgactccttattttt agacattagatatgccaaaatcatagccccgcttctatttactcccgcagcacaatgaaccaacacgggctcgtttcgt t gatcacatttagataaaaaggcggttacgtcgtcaaaatatttactaatatcggtagttgtatcatctaccaacggtat at gaataatattaatattagagttaggtaatgtatatttatccatcgtcaaatttaaaacatatttgaacttaacttcaga tgatg gtgcatccatagcatttttataatttcccaaatacacattattggttacccttgtcattatagtgggagatttggctct gtgcat atctccagttgaacgtagtagtaagtatttatacaaacttttcttatccatttataacgtacaaatggataaaactact ttatc ggtaaacgcgtgtaatttagaatacgttagagaaaaggctatagtaggcgtacaagcagccaaaacatcaacactt atattctttgttattatattggcaattagtgcgctattactctggtttcagacgtctgataatccagtctttaatgaat taacgag atatatgcgaattaaaaatacggttaacgattggaaatcattaacggatagcaaaacaaaattagaaagtgatagag gtagacttctagccgctggtaaggatgatatattcgaattcaaatgtgtggatttcggcgcctattttatagctatgcg attg gataagaaaacatatctgccgcaagctattaggcgaggtactggagacgcgtggatggttaaaaaggcggcaaag gtcgatccatctgctcaacaattttgtcagtatttgataaaacacaagtctaataatgttattacttgtggtaatgaga tgtta aatgaattaggttatagcggttattttatgtcaccgcattggtgttccgattttagtaatatggaatagtgttagataa atgcg gtaacgaatgttcctgtaaggaaccataacagtttagatttaacgttaaagatgagcataaacataataaacaaaatta caatcaaacctataacattaatatcaaacaatccaaaaaatgaaatcagtggagtagtaaacgcgtacataactcct ggataacgtttagtagctgccgttcctattctagaccaaaaattcggtttcatgttttcgaaacggtgttctgcaacaa gtc ggggatcgtgttctacatatttggcggcattatccagtatctgcctattgatcttcatttcgttttcaattctggctat ttcaaaat aaaatcccgatgatagacctccagactttataatttcatctacgatgttcagcgccgtagtaactctaataatataggc tg ataagctaacatcataccctcctgtatatgtgaatatggcatgatttttgtccattacaagctcggttttaactttatt gcctgt aataatttctctcatctgtaggatatctatttttttgtcatgcattgccttcaagacgggacgaagaaacgtaatatcc tcaat aacgttatcglittctacaataactacatattctacctttttattttctaactcggtaaaaaaattagaatcccatagg gctaa atgtctagcgatatttcttttcgtttcctctgtacacatagtgttacaaaaccctgaaaagaagtgagtatacttgtca tcattt ctaatgtttcctccagtccactgtataaacgcataatccttgtaatgatctggatcatccttgactaccacaacatttc tttttt ctggcataacttcgttgtcctttacatcatcgaacttctgatcattaatatgctcatgaacattaggaaatgtttctga tggaa gtctatcaataactgg cacaacaataacaggagttttcg ccgccgccatttagttattgaaattaatcatatacaactcttt aatacgagttatattttcgtctatccattgtttcacatttacatatttcgacaaaaagatataaaatgcgtattccaat gcttct

-174-ctgtttaatgaattactaaaatatacaaacacgtcactgtctggcaataaatgatatcttagaatattgtaacaattta ttttg tattgcacatgttcgtgatctatgagttcttcttcgaatggcataggatctccgaatctgaaaacgtataaataggagt tag aataataatatttgagagtattggtaatatataaactctttagcggtataattagttlitttctctcaatttctatttt tagatgtgat ggaaaaatgactaattligtagcattagtatcatgaactctaatcaaaatcttaatatcttcgtcacacgttagctctt tgaa gtttttaagagatgcatcagttggttcgaccgatggagtaggtgcaacaattttttglicgatgtatgtatgtactgga gcca ttgttttaactataatggtgcttgtatcgaaaaactttaatgcagatagcggaagctcttcgccgcgactttctacatc gtaa ttgggttctaacgccgatctctgaatggatactagttttctaagttctaatgtgattctctgaaaatgtaaatccaatt cctcc ggcattatagatgtgtatacatcggtaaataaaactatagtatccaacgatcccttctcgcaaattctagtcttaacca aa aaatcgtatataaccacggagatgg cgtatttaagagtg gattcttctaccgttttgttcttggatgtcatataggaaactat aaagtccgcactactgttaagaatgattactaacgcaactatatagttcaaattaagcattttggaaacataaaataac t ctgtagacgatacttgactttcgaataagtttgcagacaaacgaagaaagaacagacctctcttaatttcagaagaaa actttttttcgtattcctgacgtctagagtttatatcaataagaaagttaagaattagtcggttaatgttgtatttcat tacccaa gtttgag atttcataatattatcaaaagacatgataatattaaag ataaagcgctgactatg aacgaaatagctatatgg ttcgctcaaaaatatagtcttgttaaacgtggaaacgataactgtatttttaatcacgtcagcggcatctaaattaaat ata ggtatatttattccacacactctacaatatgccacaccatcttcataataaataaattcgttagcaaaattattaattt tagtg aaatagttagcgtcaactttcatagcttccttcaatctaatttgatg ctcacacggtg cgaattccactctaacatcccttttc catg cctcaggttcatcgatctctataatatctagttttttg cgtttcacaaacacag gctcgtctctcgcgatgagatctgta tagtaactatgtaaatgataactagatagaaag atgtagctatatag atgacgatcctttaagag aggtataataacttt accccaatcagatagactgttgttatggtcttcggaaaaagaatttttataaatttttccagtattliccaaatatacg tactta acatctaaaaaatccttaatgataataggaatggataatccgtctattttataaagaaatacatatcgcacattatact tttt tttggaaatgggaataccgatgtgtctacataaatatgcaaagtctaaatattttttagagaatcttaattggtccaaa ttctt ttccaagtacggtaatagatttttcatattgaacggtatcttcttaatctctggttctagttccgcattaaatgatgaa actaag tcactatttttataactaacgattacatcacctctaacatcatcatttaccagaatactgatcttcttttgtcgtaaat acatgtc taatgtgttaaaaaaaagatcatacaagttatacgtcatttcatctgtggtattcttgtcattgaaggataaactcgta ctaa tctcttctttaacagcctgttcaaatttatatcctatatacgaaaaaatagcaaccagtgtttgatcatccgcgtcaat attct gttctatcgtagtgtataacaatcgtatatcttcttctgtgatagtcgatacgttataaaggttgataacgaaaatatt tttattt cgtgaaataaagtcatcgtaggattttggacttatattcgcgtctagtagatatgcttttatttttggaatgatctcaa ttagaa tagtctctttagagtccatttaaagttacaaacaactag gaaattg gtttatg atgtataatttttttagtttttatagattctttatt ctatacttaaaaaatgaaaataaatacaaaggttcttgagggttgtgttaaattgaaagcgagaaataatcataaatta t ttcattatcgcgatatccgttaagtttgtatcgtaatg gcgtggtcaattacaaataaagcggatactagtagcttcacaaa gatggctgaaatcagagctcatctaaaaaatagcgctgaaaataaagataaaaacgaggatattttcccggaagat gtaataattccatctactaag cccaaaaccaaacgagccactactcctcgtaaaccagcggctactaaaagatcaac caaaaaggaggaagtggaagaagaagtagttatagaggaatatcatcaaacaactgaaaaaaattctccatctcct ggagtcagcgacattgtagaaagcgtggccgctgtagagctcgatgatagcgacggggatgatgaacctatggtac

-175-aagttgaagctggtaaagtaaatcatagtgctagaagcgatctctctgacctaaaggtggctaccgacaatatcgttaa agatcttaagaaaattattactagaatctctgcagtatcgacggttctagaggatgttcaagcagctggtatctctaga ca atttacttctatgactaaagctattacaacactatctgatctagtcaccgagggaaaatctaaagttgttcgtaaaaaa gtt aaaacttgtaagaagtaaatgcgtgcacttttttataaagatggtaaactctttaccgataataattttttaaatcctg tatca gacgataatccagcgtatgaggttttgcaacatgttaaaattcctactcatttaacagatgtagtagtatatgaacaaa c gtgggaggaggcgttaactagattaatttttgtgggaagtgattcaaaaggacgtagacaatacttttacggaaaaatg catgtacagaatcgcaacgctaaaagagatcgtatttttgttagagtatataacgttatgaaacgaattaattgtttta taa acaaaaatataaagaaatcgtccacag attccaattatcagttgg cggtttttatgttaatggaaactatgttttttattag at ttggtaaaatgaaatatcttaaggagaatgaaacagtagggttattaacactaaaaaataaacacatagaaataagt cccgatgaaatagttatcaagtttgtaggaaaggacaaagtttcacatgaatttgttgttcataagtctaatagactat ata agccgctattgaaactgacggatgattctagtcccgaagaatttctgttcaacaaactaagtgaacgaaaggtatatga atgtatcaaacagtttggtattagaatcaaggatctccgaacgtatggagtcaattatacgtlittatataatttttgg acaa atgtaaagtccatatctcctcttccatcaccaaaaaagttaatag cgttaactatcaaacaaactg ctgaagtg gtaggt catactccatcaatttcaaaaagagcttatatggcaacgactattttagaaatggtaaaggataaaaattttttagatg ta gtatctaaaactacgttcgatgaattcctatctatagtcgtagatcacgttaaatcatctacggatggatgatatagat cttt acacaaataattacaaaaccgataaatggaaatggataagcgtatgaaatctctcgcaatgaccgctttctttgggga gctaagcacattagatattatggcattgataatgtctatatttaaacgccatccaaacaataccattttttcagtggat aag gatggtcagtttatgattgatttcgaatacgataattataaggcttctcaatatttggatctgaccctcactccgatat ctgga gatgaatgcaagactcacgcatcgagtatagccgaacaattggcgtgtgtggatattattaaagaggatattagcgaa tatatcaaaactactccccgtcttaaacg atttataaaaaaataccg caatagatcagatactcgcatcagtcgagata cagaaaagcttaaaatagctctagctaaaggcatagattacgaatatataaaagacgcttgttaataagtaaatgaaa aaaaactagtcgtttataataaaacacgatatggatgccaacgtagtatcatcttctactattgcgacgtatatagacg ct ttagcgaagaatgcttcggaattagaacagaggtctaccgcatacgaaataaataatgaattggaactagtatttatta agccgccattgattactttgacaaatgtagtgaatatctctacgattcaggaatcgtttattcgatttaccgttactaa taag gaaggtgttaaaattagaactaagattccattatctaaggtacatggtctagatgtaaaaaatgtacagttagtagatg c tatagataacatagtttgggaaaagaaatcattagtgacggaaaatcgtcttcacaaagaatgcttgttgagactatcg acagaggaacgtcatatatttliggattacaagaaatatggatcctctatccgactagaattagtcaatcttattcaag ca aaaacaaaaaactttacgatagactttaagctaaaatattttctaggatccggtgcccagtctaaaagttctttattac ac gctattaatcatccaaagtcaaggcctaatacatctctggaaatagaatttacacctagagacaatgaaacagttccat atgatgaactaataaaggaattgacgactctctcgcgtcatatatttatggcttctccagagaatgtaattctttctcc gcct attaacgcgcctataaaaacctttatgttgcctaaacaagatatagtaggtttggatctggaaaatctatatgccgtaa ct aagactgacggcattcctataactatcagagttacatcaaacgggttgtattgttattttacacatcttggttatatta ttaga tatcctgttaagagaataatagattccgaagtagtagtctttggtgaggcagttaaggataagaactggaccgtatatc t cattaagctaatagagcctgtgaatgcaatcaatgatagactagaagaaagtaagtatgttgaatctaaactagtggat

-176-atttgtgatcggatagtattcaagtcaaagaaatacgaaggtccgtttactacaactagtgaagtcgtcgatatgttat ct acatatttaccaaagcaaccagaaggtgttattctglictattcaaagggacctaaatctaacattgattttaaaatta aa aaggaaaatactatagaccaaactgcaaatgtagtatttaggtacatgtccagtgaaccaattatctttggagagtcgt ctatctttgtagagtataagaaatttagcaacgataaaggctttcctaaagaatatggttctggtaagattgtgttata taac ggcgttaattatctaaataatatctattgtttggaatatattaatacacataatgaagtgggtattaagtccgtggttg tacct attaagtttatagcagaattcttagttaatggagaaatacttaaacctagaattgataaaaccatgaaatatattaact ca gaagattattatggaaatcaacataatatcatagtcgaacatttaagagatcaaagcatcaaaataggagatatcttta acgag gataaactatcggatgtg ggacatcaatacg ccaataatgataaatttagattaaatccagaagttagttatttt acgaataaacgaactagaggaccgttgggaattttatcaaactacgtcaagactcttcttatttctatgtattgttcca aaa catttttagacgattccaacaaacgaaaggtattggcgattgattttggaaacggtgctgacctggaaaaatactttta tg gagagattgcgttattggtagcgacggatccggatgctgatgctatagctagaggaaatgaaagatacaacaaatta aactctggaattaaaaccaagtactacaaatttgactacattcag gaaactattcgatccgatacatttgtctctagtgtc ag agaagtattctattttggaaagtttaatatcatcgactggcagtttg ctatccattattcttttcatccgagacattatgcta ccgtcatgaataacttatccgaactaactgcttctggaggcaaggtattaatcactaccatggacggagacaaattatc aaaattaacagataaaaagacttttataattcataag aatttacctagtagcgaaaactatatgtctgtagaaaaaata g ctg atgatagaatagtggtatataatccatcaacaatgtctactccaatg actgaatacattatcaaaaagaacgata tagtcagagtgtttaacgaatacggatttgttcttgtagataacgttgatttcgctacaattatagaacgaagtaaaaa gttt attaatggcgcatctacaatggaagatagaccatctacaagaaactttttcgaactaaatagaggagccattaaatgt gaaggtttagatgtcgaagacttacttagttactatgttgtttatgtcttttctaagcggtaaataataatatggtatg ggttct gatctcccagttctaaatgcattaaataattccaatagagcgatttttgttcctataggaccttccaactgtggatact ctgt attgttaatagatatattaatacttttgtcgggtaacagag gttctacgtcttttaaaaataaaagtttgataacatctggcct gttcataaataaaaacttggcgattctatatatactcttattatcaaatctagccattgtcttatagatgtgagctact gtagg tgtaccatttgattttctttctaatactatatatttctctcgaagaagttcttgcacatcatctgggaataaaatacta ctgttga gtaaatcagttatttthttatatcgatattgatggacatttttatagttaaggataataagtatcccaaagtagataac gacg ataacgaagtatttatacttttaggaaatcacaatgactttatcagattaaaattaacaaaattaaaggagcatgtatt tlit tctgaatatattgtgactccagatacatatg gatctttatgcgtcgaattaaatgg gtctagttttcagcacgg cggtag at atatagaggtggaggaatttatagatgctggaagacaagttagatggtglictacatccaatcatatatctaaagatat a cccgaagatatgcacactgataaatttgtcatttatgatatatacacttttgacgctttcaagaataaacgattggtat tcgt acaggtacctccgtcgttaggagatgatagtcatttgactaatccgttattgtctccgtattatcgtaattcagtagcc aga caaatggtcaatgatatgatlittaatcaagattcatttttaaaatatttattagaacatctgattagaagccactata gagttt ctaaacatataacaatagttag atacaag gataccgaagaattaaatctaacgagaatatgttataatagagataagt ttaaggcgtttgtattcgcttggtttaacggcgtttcggaaaatgaaaaggtactagatacgtataaaaaggtatctaa ttt gatataatgaattcagtgactgtatcacacgcgccatatactattacttatcacgatgattgggaaccagtaatgagtc a attggtagagttttataacgaagtagccagttggctg ctacgagacgagacgtcgcctattcctgataagttctttataca

-177-gttgaaacaaccgcttagaaataaacgagtatgtgtgtgcggtatagatccgtatccgaaagatggaactggtgtacc gttcgaatcaccaaattttacaaaaaaatcaattaaggagatagcttcatctatatctagattaaccggagtaattgat ta taaaggttataaccttaatataatagacggggttataccctggaattattacttaagttgtaaattaggagaaacaaaa a gtcacgcgatctactgggataagatttccaagttactgctgcagcatataactaaacacgttagtgttctttattgttt gggt aaaacag atttctcgaatatacggg ccaagttag aatccccggtaactaccatagtcggatatcatccagcggctaga gaccgccaattcgagaaagatagatcatttgaaattatcaacgttttactggaattagacaacaaggcacctataaatt gggctcaagggtttatttattaatgctttagtgaaattttaacttgtgttctaaatggatgcggctattagaggtaatg atgtta tctttgttcttaagactataggtgtcccgtcagcgtgcagacaaaatgaagatccaagatttgtagaagcatttaaatg cg acgagttagaaagatatattgagaataatccagaatgtacactattcgaaagtcttagggatgaggaagcatactctat agtcagaattttcatggatgtagatttagacgcgtgtctagacgaaatagattatttaacggctattcaagattttatt atcg aggtgtcaaactgtgtagctagattcgcgtttacagaatgcggcgccattcatgaaaatgtaataaaatccatgagatc t aatttttcattgactaagtctacaaatagagataaaacaagttttcatattatctttttagacacgtataccactatgg atac attgatagctatgaaacgaacactattagaattaagtagatcatctgaaaatccactaacaagatcgatagacactgc cgtatataggag aaaaacaactcttcgggttgtaggtactaggaaaaatccaaattg cgacactattcatgtaatgca accaccgcatgataatatagaagattacctattcacttacgtggatatgaacaacaatagttattacttttctctacaa ca acgattggaggatttagttcctgataagttatgggaaccag ggtttatttcattcgaagacgctataaaaagagtttcaaa aatattcattaattctataataaactttaatgatctcgatgaaaataattttacaacggtaccactggtcatagattac gtaa caccttgtgcattatgtaaaaaacgatcgcataaacatccgcatcaactatcgttggaaaatggtgctattagaattta c aaaactggtaatccacatagttgtaaagttaaaattgttccgttggatggtaataaactgtttaatattgcacaaagaa tttt ag acactaactctgttttattaaccgaacgaggagaccatatagtttg gattaataattcatggaaatttaacagcgaag aacccttgataacaaaactaattttgtcaataagacatcaactacctaaggaatattcaagcgaattactctgtccaag aaaacgaaagactgtagaagctaacatacgagacatgttagtagattcagtagagaccgatacctatccggataaa cttccgtttaaaaatggtgtattggacctggtagacggaatgttttactctggagatgatgctaaaaaatatacgtgta ctg tatcaaccggatttaaatttgacgatacaaagttcgtcg aagacagtccagaaatggaagagttaatgaatatcattaa cgatatccaaccattaacggatgaaaataagaaaaatagagagctatatgaaaaaacattatctagttgtttatgcggt g ctaccaaaggatgtttaacattcttttttgg agaaactg caactggaaagtcgacaaccaaacgtttgttaaagtctgct atcggtgacctgthgttgagacgggtcaaacaattttaacagatgtattggataaaggacctaatccatttatcgctaa c atgcatttgaaaagatctgtattctgtagcgaactacctgattttgcctgtagtggatcaaagaaaattagatctgaca at attaaaaagttgacagaaccttgtgtcattggaagaccgtgtttctccaataaaattaataatagaaaccatgcgacaa tcattatcgatactaattacaaacctgtttttgataggatagataacgcattaatgagaagaattgccgtcgtgcgatt ca gaacacacttttctcaaccttctggtagagaggctgctgaaaataatgacgcgtacgataaagtcaaactattagacg aggggttagatggtaaaatacaaaataatagatatagattcgcatttctatacttgttggtgaaatggtacagaaaata t catglicctattatgaaactatatcctacacccgaagagattcctgactttgcattctatctcaaaataggtactctgt tagta tctag ctctgtaaagcatattccattaatgacggacctctccaaaaagg gatatatattgtacgataatgtggtcactcttc

-178-cgttgactactttccaacagaaaatatccaagtattttaattctag actatttggacacgatatagagagcttcatcaatag acataagaaatttgccaatgttagtgatgaatatctgcaatatatattcatagaggatatttcatctccgtaaatatat gctc atatatttatagaagatatcacatatctaaatgaataccg gaatcatagatttatttgataatcatgttgatagtataccaac tatattacctcatcagttagctactctagattatctagttagaactatcatagatgagaacagaagcgtgttattgttc catat tatgggatcaggtaaaacaataatcgctttgttgttcgccttggtagcttccagatttaaaaaggtttacattctagtg ccta atatcaacattttgaaaatttttaattataatatgggtgtagctatgaacttgtttaatgacgaattcatagctgagaa tatctt tattcattccacaacaagtttttattctcttaattataacgataacgtcattaattataacggattatctcgctacaat aactct atttttatcgttgatgaggcacataatatctttgggaataatactggagaacttatgaccgtgataaaaaataaaaaca a gattccttttctactattgtctggatctcccattactaacacacctaatactctgggtcatattatagatttaatgtcc gaagag acgatagattttggtgagattattagtcgtggtaagaaagtaattcagacacttcttaacgaacgcggtgtgaatgtac tt aaggatttgcttaaaggaagaatatcatattacgaaatgcctgataaagatctaccaacgataagatatcacggacgt aagtttctagatactagagtagtatattgtcacatgtctaaacttcaagagagagattatatgattactagacgacagc ta tgttatcatgaaatgtttgataaaaatatgtataacgtgtcaatggcagtattgggacaacttaatctgatgaataatt tag atactttatttcaggaacaggataaggaattgtacccaaatctgaaaataaataatggcgtgttatacggagaagaatt ggtaacgttaaacattagttccaaatttaaatactttattaatcggatacagacactcaacggaaaacattttatatac tttt ctaattctacatatggcggattggtaattaaatatatcatg ctcagtaatgg atattctgaatataatggttctcagg gaact aatccacatatgataaacggcaaaccaaaaacatttgctatcgttactagtaaaatgaaatcgtctttagaggatctat t agatgtgtataattctcctgaaaacgatgatggtagtcaattgatgtlittgttttcgtcaaacattatgtccgaatcc tatact ctgaaagaggtaaggcatatttggtttatgactatcccagatactttttctcaatacaaccaaattcttggacgatcta ttag aaaattctcttacgccgatatttctgaaccagttaatgtatatcttttagccgccgtatattccgatttcaatgacgaa gtaa cgtcattaaacgattacacacaggatgaattgattaatgttttaccatttgacatcaaaaagctgttatatctaaaatt taa gactaaagaaacgaatagaatatactctattcttcaagagatgtctgaaacgtattctcttccaccacatccatcaatt gt aaaagttttattgggagaattggtcagacaatttttttataataattctcgtattaagtataacgactccaagttactt aaaat g gttacatcagttataaaaaataaagaagacgctaggaattacatagatgatattgtaaacggtcacttctttgtatcg a ataaagtatttgataaatctcttttatacaaatacgaaaacgatattattacagtaccgtttagactttcctacgaacc atttg tttggggagttaactttcgtaaagaatataacgtggtatcttctccataaaactgatgaaatatataaagaaataaatg tc gagctttgttaccaatggataccttccagttacattggaaccacacgagctgacgttagacataaaaactaatattagg aatgccgtatataagacgtatctccatagagaaattagtggtaaaatggccaagaaaatagaaattcgtgaagacgt ggaattacctctcggcgaaatagttaataattctgtagttataaacgttccgtgtgtaataacctacgcgtattatcac gttg gggatatagtcagaggaacattaaacatcgaagatgaatcaaatgtaactattcaatgtggagatttaatctgtaaact aagtagagattcgggtactgtatcatttagcgattcaaagtactgcttttttcgaaatggtaatgcgtatgacaatggc ag cgaagtcactgccgttctaatggaggctcaacaaggtatcgaatctagttttgtlittctcgcgaatatcgtcgactca taa aaaag agaatagcggtaagtataaacacgaatactatgg caataattgcgaatgttttattctcttcgatatatttttgata atatgaaaaacatgtctctctcaaatcggacaaccatctcataaaatagttctcgcgcgctggagaggtagttgctgct c

-179-gtataatctccccagaataatatacttgcgtgtcgtcgttcaatttatacggatttctatagttctctgttatataatg cggttttc catcatgattagacgacgacaatagtgttctgaatttagatagttgatcagaatgaatglitattggcgttggaaaaat tat ccatacagcgtctgcagagtggttgatagttgttcctagatatgtaaaataatccaacttactaggcagcaaattgtct ag ataaaatactgaatcaaacggtgcagacgtattgg cggatctaatggaatccaattgattaactatcttttgaaaatata catttttatgatccaatacttgtaagaatatagaaataatgataagtccatcatcgtgtttttttgcctcttcataaga actata ttttttcttattccaatg aacaagattaatctctccagagtatttgtacacatctatcaagtg attggatccataatcgtcttcct ttccccaatatatatgtagtgatgataacacatattcattgg ggagaaaccctccacttatatatcctcctttaaaattaatc cttactagttttccagtglictggatagtggttggtttcgactcattataatgtatgtctaacggcttcaatcgcgcgt tagaaa ttgctthttagtttctatattaataggagatagttgttgcggcatagtaaaaatgaaatgataactgtttaaaaatagc tctta gtatgggaattacaatggatgaggaagtgatatttgaaactcctagagaattaatatctattaaacgaataaaagatat t ccaagatcaaaagacacgcacgtgtttgctgcgtgtataacaagtgacggatatccgttaataggagctagaagaac ttcattcgcgttccaggcgatattatctcaacaaaattcagattctatctttagagtatccactaaactattacgglit atgta ctacaatgaactaagagaaatctttagacggttgagaaaagglictatcaacaatatcgatcctcactttgaagagtta atattattgggtggtaaactagataaaaaggaatctattaaagattgtttaagaagagaattaaaagaggaaagtgat gaacgtataacagtaaaagaattcggaaatgtaattctaaaacttacaacgcgcgataaattatttaataaagtatata t aggttattgcatggcgtgttttattaatcaatcgttggaggatttatcgcatactagtatttacaatgtagaaattaga aaga ttaaatcattaaatgattgtattaacgacgataaatacgaatatctgtcttatatttataatatgctagttaatagtaa atgaa cttttacagatctagtataattagtcagattattaagtataatagacg actag ctaagtctattatttgcgagg atgactctc aaattattacactcacggcattcgttaaccaatgcctatggtgtcataaacgagtatccgtgtccgctattttattaac tact gataacaaaatattagtatgtaacagacgagatagtlitctctattctgaaataattagaactagaaacatgtttagaa a gaaacgattatttctgaattattccaattatttgaacaaacaggaaagaagtatactatcgtcatttttttctctagat ccagc tactgctgataatgatagaatagacgctatttatccgggtggcatacccaaaaggggtgagaatgttccagagtgttta t ccagggaaattaaagaagaagttaatatagacaattcttttgtattcatagacactcggttttttattcatg gcatcatag a agataccattattaataaattttttgaggtaatcttctttgtcg gaagaatatctctaacgagtg atcaaatcattgatacattt aaaagtaatcatgaaatcaaggatctaatatttttagatccgaattcaggtaatggactccaatacgaaattgcaaaat atgctctagatactgcaaaactcaaatgttatggccatagaggatgttattacgaatcattaaaaaaattaactgagga t gattgattagaaaatataaattaatttaccatcgtgtatlittataacgggattgtccggcatatcatgtagatagtta ccgtc tacatcgtatactcgaccatctacgcctttaaatcctctatttattgacattaatctattagaattggaataccaaata ttagt accctcaattagtttattggtaatatttttgttagacgatag atcgatg gctcttgaaaccaaggttttccaaccggactcatt gtcgatcggtgagaagtctttttcattagcatgaatccattctaatgatgtatgtttaaacactctaaacaattggaca aatt cttttgatttgctttgaatgatttcaaataggtcttcgtctacagtaggcataccattagataatctagccattataaa gtgca cgtttacatatctacgttctggaggagtaagaacgtgactattgagacgaatggctcttcctactatctgacgaagaga c gcctcgttccatgtcatatctaaaatgaagatatcattgattgagaagaagctaataccctcgcctccactagaagaga atacgcatgttttaatgcattctccgttagtgtttgattcttggttaaactcagccaccgccttgattctagtatcttt tgttctag

-180-atgagaactctatattag agataccaaagactttg aaatatagtaataag atttctattcctgactgattaacaaatggttc aaagactagacatttaccatgggatgctaatattcccaaacatacatctataaatttgacgclittctclittaattca gtaa atagagagatatcagccgcactagcatcccctcccaataglictcccclittaaaggtatctaatgcagatttagaaaa tt ctctatctcttaatgaattlitaaaatcattatatagtgttgctatctcttgcgcgtattcgcccggatcacgattlig tclitcag gaaagctatcgaacgtaaacgtagtag ccatacgtctcagaattctaaatg atgatatacctglitttatttcagcgagttt agcclittgataaatttclicttgctlittcgacatattaacgtatcgcattaatactglittcttagcgaatgatgca gacccttc tacgtcatcaaaaatagaaaactcgttattaactatgtacgaacataggcctcctagtliggagactaattctlittca tca actagacgtttattctcaaatagcgattggtgligtaaggatcctggtcgtagtaagttaaccaacatggtgaattctt gca cactattgacgataggtgtagccgataaacaaatcatcttatggttlittaatgcgatggtcttagataaaaaattata tact gaacgagtaggacggatcttaccatclictttgattaatgatttagaaatgaagttatgacattcatcaataatgacgc at attctactcliggaattaataglittgatattagtaaaaaatttatttctaaaattttgatcatcgtaattaataaaaa tacaatc clicgttatctctggagcgtatctgagtatagtglicatccaaggatclictatcaaagcctlittcaccaataagata atag cccaattcgtataaatatccttaagatglitgagaatatatacagtagtcattglittaccgacacccgtlicatggaa caat aaaagagaatgcatactgtctaatcctaagaaaactcttgctacaaaatgttgataatccttgaggcgtactacgtccg accccatcatttcaacag gcatattagtagttctg cgcaatgcataatcgatatag gccgcgtgtgatttactcatttatga gtgataagtaataactatglittaaaaatcacagcagtagtttaactagtclictctgatglitglittcgatactlit tgaatca gaagtcatactagaataaagcaacgagtgaacgtaatagagagcttcgtatactctattcgaaaactctaagaactta ttaatgaattccgtatccactggattglitaaaatactaaattgaacactglicacatccttccaagaagaagacttag tg a cggacttaacatgagacataaataaatccaaattlittttacaaacatcactagccaccataatggcgctatclittaa cc agctatcgcttacgcattttagcagtctaacattlitaaagagactacaatatattctcatagtatcgattacacctct accg aataaagttggaagtttaataatacaatattlitcgtttacaaaatcaaataatggtcgaaacacgtcgaaggttaaca tc ttataatcgctaatgtatagattgttttcagtgagatgattattagatttaatagcatctcgttcacgtttgaacagtt tattgcgt gcgctgaggtcggcaactacggcgtccgctttagtactcctcccataatactttacgctattaatctttaaaatttcat aga clitatctagatcgctlictggtaacatgatatcatgtgtaaaaaglittaacatgtcggtcggcattctatttagatc attaact ctagaaatctgaagaaagtaattagctccgtattccagactaggtaatgggclittacctagagacagattaaglictg g caatglitcataaaatggaagaaggacatgcgttccctcccggatattlittacaatttcatccatttacaactctata gtttg ttlicattattattagttattatctcccataatcliggtaatacttaccccttgatcgtaagataccttatacaggtca ttacatac aactaccaattglitttgtacataatagattggatggttgacatccatggtggaataaactactcgaacagatagttta tctt tccccctagatacattagccgtaatagttgtcggcctaaagaatatclitggtgtaaagttaaaagttaggglicttgl icca ttattgctlittgtcagtagttcattataaattctcgagatgggtccgttctctgaatatagaacatcatttccaaatc taacttct agtctagaaataatatcggtcttattcttaaaatctattcccttgatgaagggatcgttaatgaacaaatccttggcct ttgat tcggctgatctattatctccgttatagacgttacgttgactagtccaaagacttacaggaatagatgtatcgatgatgt tgat actatgtgatatgtgagcaaagattglictcttagtggcatcactatatgliccagtaatggcggaaaactlittagaa atgt tatatataaaagaattlittcgtgliccaaacattagcagattagtatgaagataaacactcatattatcaggaacatt atc

-181-aatttttacatacacatcagcatcttgaatag aaacgataccatcttctg gaacctctacg atctcgg cag actccgg at aaccagtcggtggaccatcgctaacaataactagatcatccaacaatctactcacatatgcatctatataatctttttc at cttgtgagtaccctggatacgaaataaatttattatccgtatttccataataaggtttagtataaacagagagcgatgt tgc cgcatgaacttcagttacagtcgccgttggttggtttatttgacctattactctcctaggtlictctataaatgatggt ttaatttg tacattcttaaccatatatccaataaagctcaattcaggaacataaacaaattctttgttgaacgtttcaaagtcgaac ga agagtcacgaataacgatatcggatactggattgaaggttaccgttacggtaatttttgaatcggatagtttaagactg ct gaatgtatcttccacatcaaacggaglittaatataaacgtatactgtagatggttctttaatagtgtcattaggagtt aggc caatagaaatatcattaagttcactagaatatccagagtgtttcaaagcaattgtattattgatacaattattatataa ttctt cgccctcaatttcccaaataacaccgttacacgaagag atagatacgtgattaatacatttatatccaacatatggtacg taaccgaatcttcccatacctttaacttctggaagttccaaactcagaaccaaatgattaagcgcagtaatatactgat c cctaatttcgaag ctagcgatagcctgattgtctggaccatcgtttgtcataactccg gatagagaaatatattg egg cat atataaagttggaatttgactatcgactgcgaagacattagaccgtttaatagagtcatccccaccgatcaaagaatta atgatagtattattcattttctatttaaaatggaaaaagcttacaataaactccgtagagaaatatctataatttgtga gttttc cttaaagtaacagcttccgtaaacgccgtctttatctcttagtaagtttattgtatttataacclittccttatcttca tagaatac taaaggcaacaaagaaatttttggttcttctctaagagctacgtgagacttaaccatagacgccaacgaatccctacat attttagaacagaaatacccaacttcaccacccttgaatgtctcaatactaataggtttaaaaaccaaatcttgattac a aaaccaacacttatcaattacactatttgtcttaatagacacatctgccatagatttataatactttggtagtatacaa gcg agtgcttcttctttagcgggcttaaagactgctttaggtgctgaaataaccacatctggaaggcttactcgcttagcca ttt aattacggaactatttttttatacttctaatgagcaagtagaaaacctctcatctacaaaaacatactcgtgtccataa tcc tctaccatagttacacgttttttagatctcatatgtgctaaaaagttttcccatactaattggttactattatttttcg tataattttta acagtttgaggttttagatttttagttacagaagtgatatcgaatattttatccaaaaagaatgaataattaattgtct tagaa ggagtgttttcttggcaaaagaataccaagtgcttaaatatttctactacttcattaatcttttctgtactcagattca gtttctc atcttttacttgattgattatttcaaagactaacttataatcctttttatttattctctcgttagccttaagaaaacta gatacaaa atttgcatctacatcatccgtggatatttgatttttttccatgatatccaagagttccgagataatttctccagaacat tgatga gacaataatctccgcaatacatttctcaaatgaataagtttattagacacatggaagtttgactttttttgtacctlig tacattt ttgaaataccgactcgcaaaaaatacaatattcatatccttgttcagatactataccgttgtgtctacaaccgctacat aat cgtagattcatgttaacactctacgtatctcgtcgtccaatattttatataaaaacattttatttctagacgttgccag aaaat cctgtaatatttttagttttttgggctgtgaataaagtatcgccctaatattgttaccgtcttccgccaatatagtagt taaattat ccgcacatgcaaaagaacaccgcttaggcggattcagtacaatgttatatttttcgtaccaactcatttaaatatcata at ctaaaatagttctgtaatatgtctagcgctaatatattgatcataatcctgtgcataaattaagatacaacaatgtctc gaa atcatcgacatggcttcttccatagttagaagatcgtcgtcaaagttagcaacgtgattcatcaacatttgctgttttg agg cagcaaatactgaaccgtcgccattcaaccattcataaaaaccatcgtctgaatccattgataatttcttgtactggtt tttg agagctcgcatcaatctagcatttctagctcccggattgaaaacagaaagaggatcgtacatccagggtccattttctg t aaatagaatcgtataatgtcccttcaagaagatatcagacgatccacaatcaaagaattggtctccgagtttgtaacaa

-182-actgcggactttaacctatacatgataccgtttagcatgatttctggtgatacgtcaatcggagtatcatctattagag atct aaagccggtgtaacattctccaccaaacatattcttattctg acgtcgttctacataaaacatcattgctccattaacgata acaggggaatgaacagcactacccatcacattagttcccaatggatcaatgtgtgtaactccagaacatcttccatatc ctatgttaggaggagcgaacaccactcliccactattgccatcgaatgccatagaataaatatccliggaattgataga aatcggactgtcggatgligtgatcatclicataggattaacaactatgtatggtgccgcctgaaglitcatatcgtaa ctg atgccgtttataggtctagccacagaaaccaacgtaggtctaaatccaactatagacaaaatagaagccaatatctgt tcctcatctgtcataacttgagag catccagtatgaataatcttcattagatggg gatctaccgcatcatcatcgttacaat aaaaaattcccattctaatglicataattgclittctaatcatggtatgcatglitgctctctgaatctctgtggaaat tagatct gatacacctgtaatcactatcggattatcctccgtaagacgattaaccaacaacatataattataagactttacttlic taa attcataaagttgctggattaggctataggtgtctccatgtacatacgcgttctcgagcgcaggaagtttaataccgaa ta gtgccatcagaataggatgaatatagtaattagtlictgglittctataaataaaagacaaatcligtgaactagacat atc ggtaaaatgcatggattggaatcgtgtagtcgacagaagaatatgatgattagatggagagtatattttatctaactct tt gagttggtcaccgattctaggactagctcgagaatgaataagtactaaaggatgagtacatttcacagaaacactagc attgttcaatgtg ctctttacatgggtaaggagttg aaatag ctcgtlictatttglictgacaatatttagtttattcataatgtta agcatatcctgaatagtaaagttagatgtgtcatacttgttagtagttagatatttagcaattgcattcccatcatttc tcaatc tcgtactccaatcatgtgtagatg ctacttcgtcgatggaaaccatacaatcctlittgatag gctgttgagattg attatttc ctgcacgtttaggtttggtacgttgatttctagcccctg egg atataaagtcatcgtctacaatttg ggacaatg aattgcat acactacaagacaaagatttatcagaagtgtgaatatgatclicatctaccaaagaaagagtttgattagtataactag attttagtcctgcgttagatgttaaaaaaacatcgctattgaccacggcttccattatttatattcgtagtlittactc gaaagc gtgattttaatatccaatcttattacttliggaatcgttcaaaacctttgactagttgtagaatttgatctattgccct acgcgtat actcccttgcatcatatacgttcgtcaccag atcgtttgtttcg gcctgaagttg gtgcatatctclitcaacattcg acatga gatccttaagggccatatcgtctagattttgttgagatgctgctcctggatttggattttgligtgctgligtacatac tgtacca ccagtaggtgtaggagtacatacagtggccacaataggaggttgaggaggtgtaaccgttggagtagtacaagaaa tatttccatccgattgligtgtacatgtagttgliggtaacgtctgagaaggttgggtagatggcggtgtcgtcgtcli ttgatc tttattaaatttagagataatatcctgaacag cattgctcg gcgtcaacgctggaag gagtgaactcgccggcgcatca gtatclicagacagccaatcaaaaagattagacatatcagatgatgtattagtttgligtcgtgglittggtgtaggaa cag tactactaggtagaagaataggagccggtgtagctgliggaaccggctgtggagttatatgaatagttggligtagcgg t tggataggctgtctgctggcgaccgtcatattatctctagctagttglictcgcaactgtclitgataatacgactctt gagac tttagtcctatttcaatcgcttcatcctlittcgtatccggatcclittclicagaataatagattgacgactliggtg tagaggat tctgccagcccctgtgagaacttgttaaagaagtccatttaaggctttaaaattgaattgcgattataagattaaatgg ca gacacagacgatattatcgactatgaatccgatgatctcaccgaatacgaggatgatgaagaagaggaagaagat ggagagtcactagaaactagtgatatagatcccaaatclicttataagattgtagaatcagcatccactcatatagaag atgcgcattccaatcttaaacatatagggaatcatatatctgctcttaaacgacgctatactagacgtataagtctatt tga aatagcgggtataatagcagaaagctataacttgcttcaacgaggaagattacctctaglitcagaattlictgacgaa

-183-acgatgaagcaaaatatgctacatgtaattatacaagagatagaggagggttcttgtcctatagtcatcgaaaagaac ggagaattgttgtcggtaaacgattttgacaaagatggtctaaaattccatctagactatattatcaaaatttggaaac ttc aaaaacgatattagaatttatacgaatatcgttctctaaatgtcacaatcaagtctcgcatgttcagcaatttattgtc gtac tttatatcgtgttcattaacgatatcttgcaaaatagtaatgattctatcttccttcgatagatattcttcagagatta ttgtcttat attttttcttgttatccgatatgaatttgataagactttgaacattattgatacccgtctgtttaattttttctacaga tattttagtttt gg cag attctatcgtatctgtcaatagacatccaacatcg acattcgacgtcaattgtctataaatcaacgtataaatttta gaaataacattagcgaattgttgtgcattgatgtcgttattctgaaacagtatgattttaggtagcattttcttaacaa agag aacgtatttattgttactcagttgaacagatgatatatccagattactaacgcatctgattccgtataccaaactttca gaa gaaatggtgtacaattgtttgtattcattcaatgtctctttttcagaaattagtttagagtcgaatactgcaataattt tcaaga gatagttttcatcagataagattttatttagtgtagatatgataaaactattgttttgttggagaacttgatacgccgc gttctct gtagtcgacgctctcaaatgggaaacaatctccattatttttttggaatcggatactatatcttcggtatcttgacgca gtct agtatacatagagttaagagagattagagtttgtacattaagcaacatgtctctaaatgtggctacaaacttliccttt ttca cataatctagtttattatataccgatttcacaacgg caccagatttaaggaaccagaatgaaaaactctgataactaca atatttcatcatagttacgattttatcatcttctatagttg gtgtaatagcgcatacctttttctccaag actg gaaccaacgtc ataaaaatgtttaaatcaaaatccatatcaacatctgatgcgctaagaccagtctcgcgttcaagattatctttactaa tg gtgacgaactcatcatatagaactctaagtttgtccattatttatttacagatttagttgtttaatttatttgtgctct tccagagtt gggatagtatttttctaacgtcggtattatattattaggatctacgttcatatgtatcataatattaatcatccacgli ttgataa atctatctttagcttctgaaataacgtatttaaacaaaggagaaaaatatttagctacggcatcagacgcaataacatt tt ttgtaaatgtaacgtatttagacgacagatcttcgttaaaaagttttccatctatgtagaatccatcggttgttaacac cattc ccgcgtcagattgaataggagtttgaatagtttgttttggaaatagatccttcaataacttatagttgggtgggaaaaa atc gattttatcactagactctttcttttttactatcattacctcatgaactatttcttgaatgagtatatgtattttcttt cctatatcgga cgcgttcattggaaaatataccatgtcgttaactataagaatatttttatcctcgtttacaaactgaataatatcagat gtag ttcgtaaacgaactatatcatcaccagcacaacatctaactatatgatatccactagtttcctttagccgtttattatc ttgttc catattagcagtcattccatcatttaag aaggcgtcaaagataatagg gagaaatg acattttggattctgttacgacttt accaaaattaaggatatacggacttactatctttttctcaacgtcgatttgatgaacacacgatgaaaatgtgclicta tga g attgatcatgtagaaaacaacaagggatacaatatttccg catatcatgaaatatattaagaaatcccaccttattata tttccccaaaggatccatgcatgtaaacattatgccgttatcattaataaagacttctttctcatcggatttgtaaaag ttgtt actgattlitttcattccaggatctagataattaataatgatgggttttctattcttattctttgtattttggcatatc ctagaccagt aaacagtttccactttggtaaaatcagcagacttttgaacgctattaaacatggcattaatggcaataactaaaaatgt a aaatatttttctatgttaggaatatggtttttcactttaatagatatatggtttttggccaaaatgatagatattlitt tatccgagg atagtaaaatattattagtcgccgtctctataaaaatgaagctagtctcgatatccaattttattctagaattgatagg agtc gccaaatgtaccttatacgttatatctcccttgatgcgttccatttgtgtatctatatcggacacaagatctgtaaata gtttta cgttattaatcatcacggtatcgccgtcgctagataacg ctaatgtaccatccaagtcccaaatggagagatttaactgtt catcgtttagaataaaatgattaccggtcatattaataaagtgttcatcgtatctagataacaacgacttataattaat gtc

-184-caagtcttgaactcgctgaatgatcttttttaacccagttagttttagattggtacgaaatatattgttaaactttgat tctaca gtaatgtccaaatctagttgtggaaatacttccatcaacattgtttcaaacttgataatattattatctacatcttcat acgatc caaattccggaatagatgtatcacatgctcttgccacccagataaccaaaaagtcacacgctccaggatatacattgt ataaaaagctatcgttlittagtagtgtttttttctgagtatatacgaagggattaaaaatagtattatcaacgtaact atattc caaattattcttatgagaatagataataatatcgtccttaatatctaacaaatttcctaaatatccctttaattgagtc attcga agcgtcaatagaatatgtctcttaactatttccggctgttgtatatttaaatgacttcgtaaaaaataatatatgggcg actt ctcatctatgtaatcatatg gagtgag atatagg gctcgttctacctcctgccccttacccacctgtaataccaattgcg g acttactatatatcgcatatttatatcgtggggtaaagtgaaaatctactaccgatgatgtaagtcttacaatgttcga acc agtaccagatcttaatttggaggcctccgtagaactaggggaggtaaatatagatcaaacaacacctatgataaagg aaaatag cggttttatatcccgtagtagacgtctattcg cccatagatctaaggatg atgagag aaaactagcactacg attctttttacaaagactttattttttagatcatagagagattcattatttgttcagatgcgttgacgctgtaaaagac gtcact attaccaaaaaaaataacattatcgtggcgccttatatagcacttttaactatcgcatcaaaaggatgcaaacttacag aaacaatgattgaagcattttttccagaactatataatgaacatagtaagaaatttaaattcaactctcaagtatccat ca tccaagaaaaactcggataccagtttggaaactatcacgtttatgattttgaaccgtattactctacagtagctctggc tat tcgagatgaacattcatctggcatttttaatatccgtcaagagagttatctggtaagttcattatctgaaataacatat agat tttatctaattaatctaaaatctgatcttgttcaatggagtg ctagtacggg cgctgtaattaatcaaatggtaaatactgtat tgattacagtgtatgaaaagttacaactggtcatagaaaatgattcacaatttacatgttcattggctgtggaatcaaa ac ttccaataaaattacttaaagatagaaatgaattatttacaaaattcattaacgagttaaaaaagaccagttcattcaa g ataagcaaacgcgataaggatacgctactaaaatattttacttaggactggagttagaatttatagacgactcatttcg tt tatcattgttactattattactattactatcattattagtgttgg cattattagtattcttcttgtcatcttgttcagaaatatacagc aatgctatacctaatactaaatacattatcatgctcgcaatggctctaacaacaacgaaccaaaatgaatttggtcgta gcttttgttcacaaaaatacataaagaaatgtctacataaatctatggcgccattggctacttgaaatagcgccagtcc t cctacagattttaatatagctgtataacatgacatttattcatcatcaaaagagacagagtcaccatctgtcatattta gatt thtttcatgtgttcaaagtatcctctactcatttcattataatagtttatcatacttagaattttaggacggatcaatg agtaag acttgactagatcgtcagtagtaatttgtgcatcgtctattctgcatccgcttcgtcgaataatgtatagcatcgcttt gagat tctccatagctatcaagtclitatacaatgacatggaaatatctgtgaatactttatacttctccaacatcgatgcctt aacat catcgcctactttagcattgaaaatacgttctattgtgtagatggatgtagcaagatttttaaacaacaatgccatctt aca cgatgattgcctcaagtctccaatcttttgtttagaacgattagctacagagttcaacgcttggctgactagcatatta ttat ctttagaaattgtattcttcaatgaggcgtttatcatatctgtgatttcgttagtcatattacagtctgactgggttgt aatgttat ccaacatatcacctatggatacg gtacacgtaccag catttgtaataatcctatctaagatgttgtatggcattg cgcag aaaatatcttctcctgtaatatctccactctcgataaatctactcagattattcttaaatgccttattctctggagaaa agata tcagtgtccatcatttcattaatagtatacgcagaaaagataccacgagtatcaattctatccaagatacttatcggli cc gagtcacagataatggtttcctctccttcgggagatcctg catagaaatatctaggacaatagtttctatactgtctgtaac tctgataatctctaaagtcactaactgataccatgaaattgagaagatcaaacgctgaagtaatcaatttttctgcctc gtt

-185-tttactacaactaglittcatcaatgtagcgacgatgtattglitagttactcliggtctaatactgatgatagagata ttattgc ttcccataatggatcttctagtagtcaccttaaagcccattgatg cgaatagcagatagataaagtcttg gtatgactcctt tctaatatagtacg gactacctttgtcacccaactttatacccacataag ccataacaacctctttaatagccgtttcatg a gglitatcagccatgagcctgagtagttggaagaatctcatgaatcccgtctcagaaagtcctatatgcatgatagatt ta tclitcctgggaaactctcgtatagtcatagatgaaatactclicaaaglitctgaaataagattagtaacagtcttac ctcc gactactctgggtaacaaacatactctaataggtglittctctgcggagataatatcagaaaggatagagcaataagta gtattattgtgattataaagaccgaatacataacaggtagaatttataaacatcatgtcctgaagglitttagacttgt attc ctcgtaatccataccgtcccaaaacatggatttggtaactttgatagccgtagatctligttccttcgccaacaggtta aag aaattaataaagaatttgligtlictatttatgtccacaaattgcacgtttggaagcgccacggttacattcactgcag cattt tgaggatcgcgagtatgaagtacgatgttattglitactggtatatctggaaagaaatctaccagtctaggaataagag a ttgatatcgcatagaaatagtaaagtttataatctcatcatcgaag agcattttgttaccattgtaataaatatccactctgtc atatgtataaatgaagtactglicaaacatgatgagatglitatatgliggcatagtagtgagatcgacgtliggtaat ggc aatgtattaagattaactccataatgtctagcag catctg cgatgttataag cgtcgtcaaagcggg gtcgatcttgtattg ttatatattgtctaacacctataagattatcaaaatcligtctgcttaatacaccgttaacaattlitgccttgaattc littattgg tgcattaataacatccttatagaggatgttaaacaaataagtgttatcaaagttaagatctggatatttclittctgct agaa catccattgagtcggagccatctggtttaatataaccaccgataaatctagctctgtattctgtatccgtcaatctaat atta agaaggtgttgagtgaaaggtggaagatcgtaaaagctgtgagtattaatgataggattagtttccgaactaatgttaa t tggggtattaataatatctatatttccagcgttaagtgtaacattaaacaglittaattcacgtgacgtggtatcaatt aaata attaatgcccaatttggatatagcagcctgaagctcatcttglitagttacggatcctaatgagttattaagcaatata tcga acggatgaacgaaggttglittaagttggtcacatactligtaatctagacatagatgcggaagaacggtagaaactat acgaaataaatattcagagtcctctaattgatcaagagtaactattgacttaataggcatcatttatttagtattaaat gac gaccgtaccagtgacggatatacaaaacgatttaattacagaglittcagaagataattatccatctaacaaaaattat gaaataactcttcgtcaaatgtctattctaactcacgttaacaacgtggtagatagagaacataatgccgccgtagtgt c atctccagaggaaatatcctcacaacttaatgaagatctatttccagatgatgattcaccggccactattatcgaacga g tacaacctcatactactattattgacg atactccacctcctactlitcgtagagagttattgatatcgg aacaacgtcaaca acgagaaaaaagatttaatattacagtatcgaaaaatgctgaagcaataatggaatctagatctatgataacttctatg ccaacacaaacaccatccligggagtagtttatgataaagataaaagaattcagatgliggaggatgaagtggttaat cttagaaatcaacgatctaatacaaaatcatctgataatttagataattttaccaaaatactatttggtaagactccgt ata aatcaacagaagttaataagcgtatagccatcgttaattatgcaaatttgaacgggtctcccttatcagtcgaggactt g gatglitglicagaggatgaaatagatagaatctataaaacgattaaacaatatcacgaaagtagaaaacaaaaaat tatcgtcactaacgtgattattattgtcataaacattatcg agcaagcattgctaaaactcggatttgaagaaatcaaag gactgagtaccgatatcacttcagaaattatcgatgtggagatcg gagatgactgcgatgctgtagcatcaaaactag gaatcggtaacagtccgglicttaatattgtattglitatactcaagatattcgttaaacgaattaaaattatttaatt taatac attcccatatccagacaacaatcgtctggattaatctglicctgtcgtctcataccggacgacatattaatctlittat tagta

-186-ggcatcttlitagatgglitctttttcccagcattaactgagtcgatacctagaagatcgtgattgatctctccgacca ttcca cgaacttctaattggccgtctctaacggtaccataaactattttaccagcattagtaacagcttggacaatctgaccat cc atcgcattgtacgatgtagtagtaactgttgttctacgtctaggagcaccagaagtatttttggagcccttggaggctg atg tagaagaagacgaggattttgattttggtttacatgtaatacattttgaactctttgattttgtatcacatgcgccggc agtca catctgtttgagaattaagattattgttgcctcctttgacggctgcatctccaccgatttgcgctagtagatttttaag ctgtgg tgtaatcttattaactgtttcgatataatcatcgtaactg cttctaacggctaaattttttttatccgccatttag aagctaaaaa tatttttatttatacagaagatttaactagattatacaatg aactaatatgatccttttccagattatttacaaacttggtatttttt ggttctggaggaggcgaatttaaattcggacttggattcggattttgtgagttcttgatcttattatacatcgagtata ggatg gcgacggtaactgctacacaaataccgatcaacaaaagaataccaatcatttattgacaataacttcactattgatca agtatgcaatatatcatcttttcactaaataagtagtaataatgattcaacaatgtcgagatatatggacgataataat tta gttcatggaaatatcgctatgattggtatgaatgactccgctaactctgtggggcgcgcagtgctttccccacatagaa t aaattagcattccgactgtgataataataccaagtataaacgccataatactcaatactttccatgtacgagtgggact g gtagacttactaaagtcaataaaggcgaagatacacgaaagaatcaaaagaatgattccagcgattagcacgccg gaaaaataatttccaatcataagcatcatgtccatttaactaataaaaattttaaatcgccgaatgaacaaagtggaat ataaaccatataaaaacaatagtttgtactgcaaaaataatatctatttttgttttcgaagatatggtaaaattaaata gta gtacacagcatgttataactaacagcagcaacggctcgtaattacttatcatttactagacgaaaaggtggtgggatat t ttcttgctcaaataatacgaatatatcacccatccattttatgcg atgtttatatactctaatctttaatagatctatagacgac gggtttaccaacaatatagattttatcgattcatctaatttaaacccttccttaaacgtgaatgatctattatctggca taacg atgaccctacctgatgaatcggacaatgtactgggccatgtagaataaattatcaacgaattatcgtctacgaacattt a tatcatttgttttaattttaggacgcgaataaatagatataaaatagaaaataacagatattacaaccagtgttatggc cg cgcccaaccaggtaggcagttttattttatcttttactacaggttctcctggatgtacgtcaccaacggcggacgtagt tct agtacaattagacgtaagttccgcttgggaattttttaacgctaaagagttaacgttaatcgtgcacccaacgtattta cat ctaglictttgaacatcttgattataatataaccattttctatctctagattcgtcggtgcactcatgtaaccaacata ccctag gtcctaaatatttatctccggaattagattttggataattcgcgcaccaacaatttctatttcctttatgatcgttaca aaaga cgtataatgccgtatccccaaaagtaaaataatcagg acgaataattctaataaactcagaacaatatctcgcatcca tatgtttggagcaaatatcggaataagtagacatagccggtttccgttttgcacgtaaccattctaaacaattggggtt tcc aggatcgtttctacaaaatccagtcatgaaatcgtcacaatgttctgtcttgtaattattattaaatatttttggacag tgtttg gtatttgtcttagaacaacattttgccacgctatcactatcgcccaggagataatcctlitttataaaatgacatcgtt gccc ggatgctatataatcagtagcgtgttttaaatccttaatatattcaggagttacctcgttctgataatagattaatgat ccag gacgaaatttgaaagaactacatggttctccatgaattaatacatattglitagcaaattcaggaactataaaactact a caatgatctatcgacataccatctatcaaacaaaacttgggtttaatttctcccggagatgtttcataatagtacgtat aac tttcttctgcaaacttaacagctctattatattcaggataattaaaacctaattccatatatttgtctcgtatatctgc tattcctg gtgctattttgattctattaagagtaacag ctgcccccattcttaataatcgtcagtatttaaactgttaaatgttg gtatatca acatctaccttatttcccgcagtataaggtttgttgcaggtatactgttcaggaatggttacatttatacttcttctat agtcctg

-187-tctttcgatgttcatcacatatgcaaagaacagaataaacaaaataatgtaagaaataatattaaatatctgtgaattc gt aaatacattgattgccataataattacagcagctacaatacacacaatagacattcccacagtgttgccattacctcca cgatacatttgagttactaagcaataggtaataactaagctagtaagaggcaatagaaaagatgagataaatatcatc aatatagagattagaggagggctatatagagccaagacgaacaaaatcaaaccgagtaacgttctaacatcattatt tttgaagattcccaaataatcattcattcctccataatcgttttgcatcatacctccatctttaggcataaacgattgc tgctgt tcctctgtaaataaatctttatcaagcactccag cacccgcag agaagtcgtcaag catattgtaatatcttaaataactc atttatatattaaaaaatgtcactattaaagatggagtataatctttatgccgaactaaaaaaaatgacttgtggtcaa cc cctaagtctttttaacgaagacggggatttcgtagaagttgaaccgggatcatcctttaagtttctgatacctaaggga tttt acgcctctccttccgtaaagacgagtctagtatttgaaacattaacaacgaccgataataaaatcactagtatcaatcc aacaaatgcgccaaagttatatcctcttcaacgcaaagtcgtatctgaagtagtttctaatatgaggaaaatgatcgaa t caaaacgtcctctatacattactcttcacttggcgtgtggatttggtaagactattaccacgtgttatcttatggctac acac ggtagaaaaaccgtcatttgcgtacccaataaaatgttaatacatcaatggaagacacaggtagaggcagtcggatt ggaacataagatatccatagatggagtaagtagtctattaaaggaactaaagactcaaagtccggatgtattaatagt agtcagtagacatctg acaaacgatg ccttttgtaaatatatcaataagcattatgatttgttcatcttg gatgaatcacat acgtataatctgatgaacaatacagcagttacaagatttttagcgtattatcctccgatgatgtgttatttlitaactg ctaca cctagaccagctaaccgaatttattgtaacagtattattaatattg ccaagttatccg atctaaaaaaaactatctatgcg gtagatagtttttttgag ccatattccacagacaatattagacatatggtaaaacg actagatgg accatctaataaatat catatatataccgagaagttattatctgtagacgagcctagaaatcaacttattcttaataccctggtagaagaattca ag tcaggaactattaatcgcattttagttattactaaactacgtgaacatatggtattattctacaaacgattattagatc ttttcg gaccagaggttgtatttataggagacgcccaaaatagacgtactccagatatggtcaaatcaatcaaggaactaaat agatttatattcgtatccaccttattttattccggtactgglitagatattcctagtttggattcgttgttcatttgct cggcagtaat caacaatatgcaaatagagcaattactagggagggtatgtcgagaaacagaactattagataggacggtatatgtatt tcctaacacatccatcaaagaaataaagtacatgataggaaatttcatg caacgaattattagtctgtctgtagataaac taggatttaaacaagaaagttatcggaaacatcaagaatccgatcccacttctgtatgtacaacatcctccagagaag aacgtgtattaaatagaatatttaactcgcaaaatcgttaagaagtttaagcgacgatccgcatgctgcgcaggccagt gtattacccctcatagtattaatataatccaatgatacttttgtgatgtcggaaatcttaaccaatttagactgacagg cag aacacgtcatgcaatcatcatcgtcatcgataactgtagtcttgggcttctlittgcggctcttcattccggaacgcac attg gtgctatccatttaggtagtaaaaaataagtcag aatatgccctataacacgatcgtg caaaacctg gtatatcgtctct atctttatcacaatatagtgtatcgacatctttattattattgacctcgtttatcttggaacatggaatgggaacattt ttgttatc aacggccacctttgccttaattccagatgttgtaaaattataactaaacagtctatcatcgacacaaatgaaattcttg ttt agacgtttgtagtttacgtatgcggctcgttcgcgtctcattttttcagatattgcaggtactataatattaaaaataa gaatg aaataacatagg attaaaaataaagttatcatg acttctagcgctgatttaactaacttaaaagaattacttagtctgtac aaaagtttgaaattttcagattctgcggctatagaaaagtataattctttggtagaatggggaacatctacttactgga aa ataggcgtgcaaaaggtagctaatgtcgagacgtcaatatctg attattatgatgaggtaaaaaataaaccgtttaatat

-188-tgatccgggctattacattttcttaccggtatattttgggagcgtctttatttattcgaagggtaaaaatatggtagaa cttgg atctggaaactcttttcaaataccagatgatatgcgaagtgcgtgtaacaaagtattagacagcgataacggaataga ctttctgagatttgttttgttaaacaatagatggataatggaagatgctatatcaaaatatcagtctccagttaatata tttaa actagctagtgagtacggattaaacatacccaaatatttagaaattgaaatagaggaagacacattatttgacgacga gttatactctattatagaacgctcttttgatgataaatttccaaaaatatccatatcgtatattaagttgggagaactt aggc ggcaagttgtagacttlitcaaattctcgttcatgtatattgagtccatcaaggtagatcgtataggagataatatttt tattcc tagcgttataacaaaatcaggaaaaaagatattagtaaaagatgtagaccatttaatacgatctaaggttagagaac atacatttgtaaaagtaaaaaagaaaaacacattttccattttatacgactatgatgggaacggaacagaaactagag gagaagtaataaaacgaattatagacactataggacgagactattatgttaacggaaagtatttctctaaggttggtag tgcaggcttaaagcaattgactaataaattagatattaatgagtgcgcaactgtcgatgagttagttgatgagattaat a aatccggaactgtaaaacgaaaaataaaaaaccaatcagcatttgatttaagcagagaatgtttgggatatccagaa gcagattttataacgttagttaataacatgcgglicaaaatagaaaattgtaaggttgtaaatttcaatattgaaaata cta attgtttaaataacccg agtattg aaactatatatgg aaactttaaccagttcgtctcaatctttaatatcgtcaccgatgtc aaaaaaagattattcgagtgaaataatatgcgcctttgatataggtgcaaaaaatcctgccagaactgttttagaagtc aaggataactccgttagggtattggatatatcaaaattagactggagttctgattgggaaaggcgcatagctaaagatt t gtcacaatatg aatacactacagttcttctagaacgtcagcctag aaggtcgccgtatgttaaatttatctattttattaaag gctttttatatcatacatcggctgccaaagttatttgcgtctcgcctgtcatgtctggtaattcatatagagatcgaaa aaag agatcggtcgaagcatttcttgattggatggacacattcggattgcgagactccgttccggatagacgcaaattagacg atgtagcggatagtttcaatttggctatgagatacgtattag ataaatgg aatactaattatacaccttataataggtgtaa atctagaaattacataaaaaaaatgtaataacgttagtaacgccattatggataatctatttacctttctacatgaaat ag aagatagatatgccagaactatttttaactttcatctaataagttgcgatgaaataggagatatatatggtcttatgaa ag aacgcatttcctcagaggatatglitgataatatagtatataataaagatatacatcctgccattaagaaactagtgta ttg cgacatccaacttactaaacacattattaatcag aatacgtatccg gtatttaacgattcttcacaagtgaaatgttgtcat tatttcgacataaactcagataatagcaatattagctctcgtacagtagagatatttgagagggaaaagtcatctcttg ta tcatatattaaaactaccaataagaagagaaaggtcaattacggcgaaataaagaaaactgttcatggaggcacta atgcaaattacttttccggtaaaaagtctgacgagtatctgagtactacagttagatccaacattaatcaaccttggat ca aaaccatttctaagagaatgagagtagatatcattaatcactctatagtaacgcgtggaaaaagctctatattacaaac tatagaaattatttttactaatagaacatgtgtgaaaatattcaaggattctactatgcacattattctatccaaggac aag gatgaaaaggggtgtatacacatgattgacaaattattctatgtctattataatttatttctgttgttcgaagatatca tccaa aacgagtactttaaagaagtagctaatgttgtaaaccacgtacttacggctacggcattagatgagaaattattcctaa t taagaaaatggctgaacacgatgtttatggagttagcaatttcaaaatagggatgtttaacctgacatttattaagtcg ttg gatcataccgttttcccctctctgttagatgaggatagcaaaataaagtlitttaaggggaaaaagctcaatattgtag ca ttacgatctctggaggattgtataaattacgtgactaaatccgagaatatgatagaaatgatgaaggaaagatcgacta ttttaaatagcatagatatagaaacggaatcggtagatcgtctaaaagaattgcttctaaaatgaaaaaaaacactgat

-189-tcagaaatggatcaacgactagggtataagtttttggtgcctgatcctaaagccggagttttttatagaccgttacatt tcc aatatgtatcgtattctaattttatattgcatcgattgcatgaaatcttgaccgtcaagcggccactcttatcgtttaa gaata atacagaacgaattatgatagaaattagcaatgttaaagtgactcctccagattactcacctataatcgcgagtattaa a ggtaagagttatgatgcattagccacgttcactgtaaatatcttlitttctagacactaaataaaatatttaaaatata atatt aatgtactaaaacttatatattattaatttatctaactaaagttagtaaattatatatataattttataattaatttaa ttttactaat tttatttagtgtctagaaaaaaa [0078] An example sequence of sVAC fragment 3 (F3, 66679 bp in length) (SEQ ID NO: 18):
thttttctagacactaaataaaatatttaaaatataatattaatgtactaaaacttatatattattaatttatctaact aaagtta gtaaattatatatataattttataattaatttaattttactaattttatttagtgtctagaaaaaaaattttgggagcg tctttatttat tcgaagggtaaaaatatggtagaacttggatctggaaactcttttcaaataccagatgatatgcgaagtgcgtgtaaca aagtattagacagcgataacggaatagactttctgagatttgttttgttaaacaatagatggataatggaagatgctat at caaaatatcagtctccagttaatatatttaaactagctagtgagtacggattaaacatacccaaatatttagaaattga a atagaggaagacacattatttgacgacgagttatactctattatagaacgctcttttgatgataaatttccaaaaatat cc atatcgtatattaagttgggagaacttaggcggcaagttgtagactttttcaaattctcgttcatgtatattgagtcca tcaa ggtagatcgtataggagataatatttttattcctagcgttataacaaaatcaggaaaaaagatattagtaaaagatgta g accatttaatacgatctaaggttagagaacatacatttgtaaaagtaaaaaagaaaaacacattttccattttatacga c tatgatgggaacggaacagaaactagaggagaagtaataaaacgaattatagacactataggacgagactattat gttaacggaaagtatttctctaaggttggtagtgcaggcttaaagcaattgactaataaattagatattaatgagtgcg ca actgtcgatgagttagttgatgagattaataaatccggaactgtaaaacgaaaaataaaaaaccaatcagcatttgatt taagcagagaatgtttgggatatccagaagcagattttataacgttagttaataacatgcggttcaaaatagaaaattg t aaggligtaaatttcaatattgaaaatactaattgtttaaataacccgagtattgaaactatatatggaaactttaacc agtt cgtctcaatctttaatatcgtcaccgatgtcaaaaaaagattattcgagtgaaataatatgcgcctttgatataggtgc aa aaaatcctgccagaactgttttagaagtcaaggataactccgttagggtattggatatatcaaaattagactggagttc t gattgggaaaggcgcatagctaaagatttgtcacaatatgaatacactacagttcttctagaacgtcagcctagaaggt cgccgtatgttaaatttatctattttattaaaggctttttatatcatacatcggctgccaaagttatttgcgtctcgcc tgtcatgt ctggtaattcatatagagatcgaaaaaagagatcggtcgaagcatttcttgattggatggacacattcggattgcgaga ctccgttccggatagacgcaaattagacgatgtagcggatagtttcaatttggctatgagatacgtattagataaatgg a atactaattatacaccttataataggtgtaaatctagaaattacataaaaaaaatgtaataacgttagtaacgccatta tg gataatctatttacctttctacatgaaatagaagatagatatgccagaactatlittaactttcatctaataagttgcg atga aataggagatatatatggtcttatgaaagaacgcatttcctcagaggatatgtttgataatatagtatataataaagat at acatcctgccattaagaaactagtgtattgcgacatccaacttactaaacacattattaatcagaatacgtatccggta tt taacgattcttcacaagtgaaatgttgtcattatttcgacataaactcagataatagcaatattagctctcgtacagta gag

-190-atatttgagagggaaaagtcatctcligtatcatatattaaaactaccaataagaagagaaaggtcaattacggcgaa ataaagaaaactgttcatggaggcactaatgcaaattacttttccggtaaaaagtctgacgagtatctgagtactacag ttagatccaacattaatcaaccttggatcaaaaccatttctaagagaatgagagtagatatcattaatcactctatagt aa cgcgtggaaaaagctctatattacaaactatagaaattatttttactaatagaacatgtgtgaaaatattcaaggattc ta ctatgcacattattctatccaaggacaaggatgaaaaggggtgtatacacatgattgacaaattattctatgtctatta ta atttatttctgttgttcgaagatatcatccaaaacgagtactttaaagaagtagctaatgttgtaaaccacgtacttac ggct acggcattagatgagaaattattcctaattaagaaaatggctgaacacgatgtttatggagttagcaatttcaaaatag g gatgtttaacctgacatttattaagtcgttggatcataccgttlicccctctctgttagatgaggatagcaaaataaag tttttt aaggggaaaaagctcaatattgtagcattacgatctctggaggattgtataaattacgtgactaaatccgagaatatga tagaaatgatgaaggaaagatcgactattttaaatagcatagatatagaaacggaatcggtagatcgtctaaaagaa ttgcttctaaaatgaaaaaaaacactgattcagaaatggatcaacgactagggtataagtttttggtgcctgatcctaa a gccggagttttttatagaccgttacatttccaatatgtatcgtattctaattttatattgcatcgattgcatgaaatct tgaccgt caagcggccactcttatcgtttaagaataatacagaacgaattatgatagaaattagcaatgttaaagtgactcctcca gattactcacctataatcgcgagtattaaaggtaagagttatgatgcattagccacgttcactgtaaatatctttaaag ag gtaatgaccaaagagggtatatccatcactaaaataagtagttatgagggaaaagattctcatttgataaaaattccgc tactaataggatacgggaataaaaatccacttgatacagccaagtatcttgttcctaatgtcataggtggagtctttat ca ataaacaatctgtcgaaaaagtaggaattaatctagtagaaaagattacaacatggccaaaatttagggttgttaagc caaactcattcactttctcgttttcctccgtatcccctcctaatgtattaccgacaagatatcgccattacaagatatc tctgg atatatcacaattggaagcgttgaatatatcatcgacaaagacatttataacggtcaatattgttttgctgtctcaata tttat ctagagtgagtctagaattcattagacgtagtttatcatacgatatgcctccagaagttgtctatctagtaaacgcgat aat agatagtgctaaacgaattactgaatctattactgactttaatattgatacatacattaatgacctggtggaagctgaa ca cattaaacaaaaatctcagttaacgatcaacgagttcaaatatgaaatgctgcataactlittacctcatatgaactat ac acccgatcaactaaagggattttatatgatatctttactaagaaagtlictctactgtatctaccacacttctagatat ccag atagagattcgatggtttgtcatcgcatcctaacgtacggcaaatattttgagacgttggcacatgatgaattagagaa tt acataggcaacatccgaaacgatatcatgaacaatcacaagaacagaggcacttacgcggtaaacattcatgtact aacaactcccggacttaatcacgcgttttctagcttattgagtggaaagttcaaaaagtcagacggtagttatcgaaca catcctcactattcatggatgcagaatatttctattcctaggagtgttggattttatccggatcaagtaaagatttcaa agat gttttctgtcagaaaataccatccaagtcaatatctttactlitgttcatcggacgttccggaaagaggtcctcaggta ggtt tagtatctcaattgtctgtcttgagttccattacaaatatactaacgtctgagtatttggatttggaaaagaaaatttg tgagt atatcagatcatattataaagatgatataagttactttgaaacaggatttccaatcactatagaaaatgctctagtcgc at ctcttaatccaaatatgatatgtgattttgtaactgactttagacgtagaaaacggatgggattcttcggtaacttgga ggt aggtattactttagttagggatcacatgaatgaaattcgcattaatattggagcgggaagattagtcagaccattcttg gtt gtggataacggagagctcatgatggatgtgtgtccggagttagaaagcagattagacgacatgacattctctgacatt cagaaagagtttccgcatgtcatcgaaatggtagatatagaacaatttacttttagtaacgtatgtgaatcggttcaaa a

-191-atttagaatgatgtcaaaggatgaaagaaagcaatacgatttatgtgactttcctgccgaatttagagatggatatgtg g catcttcattagtggg aatcaatcacaattctggacccagagctattcttgg atgtgctcaagctaaacaagctatctcttg tctgagttcggatatacgaaataaaatagacaatggaattcatttgatgtatccagagaggccaatcgtgattagtaag gctttagaaacttcaaagattgcggctaattgcttcggccaacatgttactatagcattaatgtcgtacaaaggtatca at caagaggatggaattatcatcaaaaaacaatttattcag agagg cggtctcg atatagttaccgcaaagaaacatca agtagaaattccgttggaaaactttaataacaaagaaagagataggtctaacgcctattcaaaattagaaagtaatgg attagttagactgaatgctlicttggaatccggagacgctatggcacgaaatatctcatcaagaactcttgaagatgat ttt gctagagataatcagattagcttcgatglitccgagaaatataccgatatgtacaaatctcgcgttgaacgagtacaag t agaacttactgacaaagttaaggtacgagtattaaccatgaaagaaagaagacccattctaggagataaatttacca ctagaacgagtcaaaagggaacagtcgcgtatgtcgcggatgaaacggaacttccatacgacgaaaatggtatca caccagatgtcattattaattctacatccatcttctctag aaaaactatatctatgttg atagaggttattttaacagccgcat attctgctaagccgtacaacaataagggagaaaaccgacctgtctglittcctagtagtaacgaaacatccatcgatac atatatgcaattcgctaaacaatgttatgagcattcaaatccgaaattgtccgatgaagaattatcggataaaatclit tgt gaaaagattctctatgatcctgaaacggataagccttatgcatccaaagtattlittggaccaatttattacttgcgtc tgag gcatttaactcaggacaaggcaaccgttagatgtagaggtaaaaagacgaagctcattagacaggcgaatgaggg acgaaaacgtggaggaggtatcaagttcggagaaatggagagagactglitaatagcgcatggcgcagccaatac tattacagaaglittaaaagactcagaagaggattatcaagatgtgtatglitgtgaaaattgtggagacatagcagca caaatcaagggtattaatacatgtcttagatgttcaaaacttaatctctctcctctcttaacaaaaattgataccacgc acg tatctaaagtatttcttactcaaatgaacgccagaggcgtaaaagtcaaattagatttcgaacgaaggcctccttcgli tt ataaaccattagataaagttgatctcaagccgtclittctggtgtaatattctagtttggtagtagatacatatcaata tcatc aaattcgagatccgaattataaaatgggcgtggattgttaactatagaatcggacgtctgatattcgaaaatctgtgga g littagglittggtggaggtgtaactgctacttgggatactgaagtctgatattcagaaagctgggggatglictggtt cgac atccaccgatggtgtcacatcactaatcggttcggtaacgtctgtggatggaggtgctacttctacagaacctgtagcc t cagttgtcaacggagatacattlitaatgcgaggaaatgtataatttggtaatgglitctcatgtggatctgaagaaga gg taagatatctactagaaagataccgatcacgttctaglictclittgtagaacttaactlittctlictcagcatctag ttgatatt ccaacctclicacgttactacgttcagattccaattcacgttcgcatgggttacctccgcagtlittacgagcgatttc acgtt cagccttcatgcgtctctcclictctctatcgagtttatcagagcagtclitctgaaggcgatcgaactccataaattt ctcca acgctttgattglitccatagatttccgaagttcagclittaggactgtgattctlittclitcgaattcacagctgga tgtgcaa ccgtttccattaccgccatctctaaglitclittctagatcggcaacatttcatccccatgcclittacattcctcgag tctactg tcgtcgaaatatcgttccagctcclittcgacatcaataactttagcacgttgtctctcaagctctclittgtagttat ctgattc cctggcacgtttaagatcttcatgcaattgagtcag ctcttaacacaatctcttgcttcttcgtcatagtacttacaatcacta tgggatccattgttaccacgtctacactcggcgagctcgcgtttaagagattcaatttcccgtligtattggtccatgl itcca ttgctaccaccattagatttacaggctgctagttgtcgttcgagatcagaaatacggglittcliggaattgatttcgt cgatg tacttggcatcgaaacacttattaaglictlittccaattctacgattttatttclitcgcgagtcaattccctcctgt agtaactat

-192-ctgttttgtcagattcacgctctctacgtagactttcttgcaagttactaatttgttccctagcacgtccgagtttagt tttatatg ctgaatagagttctgattcatcctttgagcagatctctagcgatcgtttaagattcctgattctagtctttagcctatt tacctcc tcagaagatgttccgttaccgttgcgtttacactcgttaagctgtctatcaagatccatgattctatctctaagacgtt gcatc tctclitccatatcagcattgctttcattattacgtctgcagtcactcaactgtctttcaatatctgagattctatctc taagacgt cgcatctctctctgtttcggcattggtttcattattacgtctacagtcgttcaactgtctttcaagatctgatattcta gattggag tctgctaatctctgtagcattttcacggcattcactcagttgtctttcaagatctgagattttagattggagtctgcta atctctg taagatttcctcctccgctctcgatgcagtcggtcaacttattctctagttctctaatacgcgaacgcagtgcatcaac ttctt gcgtgtcttcctggttgcgtgtacattcatcgagtctagattcgagatctctaacgcgtcgtcgttcttcctcaagttc tctgc gtactacagaaagcgtgtccctatcttgttgatatttagcaatttctgattctagagtactgattttgcttacgtagtt actaata gttgtcttggccttatcaagatcctccttgtatttgtcgcattccttgatatccctacgaagtctggacagttcccatt cgacat tacgacgtttatcgatttcagctcggagatcgtcatcgcgttgttttagccacatacgactgagttcaagttctcgttg acaa gatccatctacttliccattcctaatagtatccagttcclittctagttctgaacgcatttctcgttccctatcaagcg attctctc aattctcggatagtcttcttatcaatttctaataaatctgaaccatcatctgtcccattttgaatatccctgtgttctt tgatctcttt tgtaagtcggtcgattctttcggttttataaacagaatccctttccaaagtcctaatcttactgagtttatcactaagt tctgca ttcaattcggtgagttttctcttggcttcttccaactctgttttaaactctccactatttccgcattcttcctcgcatt tatctaacca ttcaattagtttattaataactagttggtaatcagcgattcctatagccgttcttgtaattgtgggaacataattagga tcttct aatggattgtatggcttgatagcatcatctttatcattattagggggatggacaaccttaattggttggtcctcatctc ctcca gtagcgtgtggttcttcaataccagtgttagtaataggcttaggcaaatgcttgtcgtacgcgggcacttcctcatcca tca agtatttataatcgggttctacgtctgaatattcttttctaagagacgcgacttcgggagttagtagaagaactctgtl ictgt atctatcaacgctggaatcaatactcaagttaag gatagcgaatacctcatcgtcatcatccgtatcttctgaaacacca tcatatgacatttcatgaagtctaacgtattg ataaatagaatcag atttagtattaaacagatccttaacctttttagtaaa cgcatatgtatattttagatctccagatttcataatatgatcacatgccttaaatgtcagtgcttccatgatataatct ggaac actaatgggtgacgaaaaagatacagcaccatatg ctacgttg ataaataaatctgaaccactaagtagataatgatt aatgttaaggaagaggaaatattcagtatatagatatgccttagcatcatatcttgtactaaacacgctaaacagttta tt gatgtgatcaatttccaacagaataattagagcagcgg gaataccaacaaacatattaccacatccgtattttctatg a atatcacatatcatgttaaaaaatcttgatagaagagcgaatatctcgtctgacttaatgagtcgtagttcagcagcaa c ataagtcataactgtaaatagaacatactttcctgtagtgttgattctagactccacatcaacaccattattaaaaata gttt tatatacatctttaatctgctctccgttaatcgtcgaacgttctagtatacggaaacactttgatttcttatctgtagt taatgac ttagtgatatcacgaagaatattacgaattacatttcttgtttlicttgagagacctgattcagaactcaactcatcgt tccat agtttttttacctcagtggcgaaatctttggagtgcttggtacatttttcaataaggttcgtgacctccatttattata aaaaatt ttattcaaaacttaactacaatcgggtaattataaaatcgtagatctcccatgtggtggaatactaccatctatcgcat gtg gatggacagtaggtaatggccatgggaacagtaatgtttgcatatttatctttcttgccagtattactgcatattgtcc caat gtttcgatgtgatgttctaacctatcaactgccgctgtatcacaacaatagtgtccgatgaaattaagattatgatcca atg tgtttaatatatgattatcaagtcttatacgatccgcgtcttttttgacaggatcaggttcttctacaggaagaagttt cggcct

-193-cttatgatattcatgtctgggaaacggtggtctagggtgaggctccggtatcggagtgggttliggattataatcatca tcg tctatgacatcatcttcgacttcgatatttattttgctatcttgatgatgtcctgtatcagttgcattttcagcactcg actgaata ttagcgcattcattgtctattattaccatatttctaaacccaaaatgtatgtgttgaacatcagtactatcgttgatga gtcttat agcatgaattcgcttatcgttatcgggtttatcttctgtcaccttagcaattccttttttattaaactctacataatca tatccattt ctattgthgttctaatataaacgagtatagcatcattgctaaatttttcaatagtatcgaaaacagaatatcctaaacc ata taatatatattcagggacactcaaactaaatgtccaggattctcctaaatacgtaaactttaatagtgcgaaatcattc aa aaatctaccacttatagatagatagtacataaatgcgtatagtagtctacctatctctttattatgaaaaccggcatta cga tcatatatgtcgtgatatacctgtgatccgtttacgttaaaccataaatacatgggtgatcctataaacatgaatttat ttcta attctcagagctatagttaattgaccgtgtaatatttgcttacatgcatacttgatacgctcattaataaaatttttat cattgct cgttatctcagaatcgtatatataaggagtaccatcgtgattcttaccagatattatacaaaatactatatataaaata tatt gaccaacgttagtaatcatataaatgtttaacgttttaaattligtattcaatgatccattatcatacgctagcatggt cttatg atattcattctttaaaatataatattgtgttagccattgcattggg gctcctaatggagattttttattctcatccattttag gata ggctlicataaagtccctaataacttcgtgaataatgtttctatgttttctactgatgcatgtatttgcttcgattttt ttatcccatg tttcatctatcatagatttaaacgcagtaatgctcg caacattaacatcttgaaccgttggtacaattccgttccataaattt ataatgttcgccatttatataactcattttttgaatatactlitaattaacaaaagagttaagttactcatatgggcgc cgtcca gtctgaacatcaatctttttagccagagatatcatagccgctcttagagtttcagcgtgattttccaacctaaatagaa cttc atcgttgcgtttacaacacttlictatttgttcaaactttgttgttacattagtaatctttttttccaaattagttagc cgttgtttgag agtttcctcattgtcgtcttcatcggctttaacaattgcttcgcgtttagcctctggctttttagcagcctttgtagaa aaaaatt cagttgctggaattgcaagatcgtcatctccggggaaaagagttccgtccatttaaagtacagattttagaaactgaca ctctgcgttatttatatttggtacaacacatggattataaatatcgatgttaataacatcagaaaatgtaaagtctata catt gttgcatcgtgttaaattttctaatggatctagtattattgggtccaacttctgcctgaaatccaaatatggaagcgga taca aaaccgtttcctggataaaccacacatctccacttttgctttacatcagaaattgtgtcgttgacatcttgaactctcc tatct aatgccggtgttccacctatagattttgaatattcgaatgctgcatgagtagcattaaattccttaatattgccataat tttcat atattgagtaaccctggataaaaagtaaacacaccgcagccgtcgctaccacaataaaaaaaattgatagagagtt catttataatctattagaagctgacaaaatttttttacacgcatcagacaatgctttaataaatagttcaacatctact litgtc atatcgaaccgatggtatgattctaacctagaattacatccgaaaaagttgactatgttcatagtcattaagtcattaa ca aacaacattccagactctggattataagacgatactgtttcgtcacaattacctaccttaatcatgtgattatgaatat tgg ctattagagcaccttctaagaaatctataatatctttgaaacacgatttaaaatcaaaccacgaatatacttctacgaa g aaagttagtttacccataggagaaataactataaatggagatctaaatacaaaatccggatctatgatagttttaacat t attatattctctattaaatacctccacatctaaaaatgttaattttgaaactatgtcttcgtttattaccgtacctgaa ctaaac gctataagctctattgtttgagaactctttaaacgatattcttgaaatacatgtaacaaagtttcctttaactcggtcg gtttat ctaccatagttacagaatttgtatccttatctataatataataatcaaaatcgtataaagttatataattatcgcgttc agatt gggatcttttcaaatagactaaaaaccccatttctctagtaagtatcttatgtatatgtttgtaaaatatcttcatggt gggaa tatgctctaccg cagttagccattcctcattgacag cggtagatgtattagacaaaactattccaatgtttaacaagggcc

-194-DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

NOTE : Pour les tomes additionels, veuillez contacter le Bureau canadien des brevets JUMBO APPLICATIONS/PATENTS
THIS SECTION OF THE APPLICATION/PATENT CONTAINS MORE THAN ONE
VOLUME

NOTE: For additional volumes, please contact the Canadian Patent Office NOM DU FICHIER / FILE NAME:
NOTE POUR LE TOME / VOLUME NOTE:

Claims (42)

PCT/US2021/016247

1. A method of producing a poxvirus vector or a recombinant poxvirus vector, comprising:
transfecting one or more DNA fragments into a host cell, wherein the one or more DNA fragments comprise the entire genomic DNA sequence of a desired poxvirus, such that the poxvirus is reconstituted in the host cell.

2. The method of claim 1, wherein two or more DNA fragments are co-transfected into the host cell, each DNA fragment comprises a partial sequence of the poxvirus genome such that the two or more DNA fragments are assembled by homologous recombination and comprise the full-length sequence of the poxvirus genome when reconstituted in the host cell.

3. The method of claim 1 or claim 2, further comprising infecting the host cell with a helper virus before, during, or after the transfection of the one or more DNA fragments to initiate the transcription of the one or more DNA fragments.

4. The method of claim 3, wherein the helper virus is Fowl pox virus (FPV), sheep fibroma virus, vaccinia virus, or cowpox virus.

5. The method of any one of claims 1-4, wherein the one or more DNA
fragments are circularized before transfection or transfected in circular forms into the host cell.

6. The method of claim 5, wherein the one or more DNA fragments are cloned into a plasmid or a bacterial artificial chromosome (BAC) vector.

7. The method of any one of claims 1-4, wherein the one or more DNA
fragments are linearized before co-transfection or transfected in linearized forms into the host cell.

8. The method of any one of claims 1-7, wherein the one or more DNA
fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments.

9. The method of any one of claims 1-8, wherein the poxvirus genomic sequence comprises the sequence of Modified Vaccinia Ankara (MVA) Accession No. #U94848 or #AY603355.

10. The method of any one of claims 1-9, wherein two adjacent DNA
fragments have an overlapping sequence to facilitate homologous recombination.

11. The method of claim 10, wherein the overlapping sequence is between about 100 bp and about 5000 bp in length.

12. The method of any one of claims 1-11, wherein the one or more DNA
fragments further comprise an inverted terminal repeat (ITR) region.

13. The method of any one of claims 1-12, wherein the one or more DNA
fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genome resolution (CR) sequence, or both, wherein the HL or the CR
sequence is added to one or both ends of the DNA fragment as single stranded or double stranded DNA sequences in sense or antisense orientation.

14. The method of claim 13, wherein the one or more DNA fragments further comprise one or more HL sequences and one or more CR sequences.

15. The method of claim 14, wherein each HL sequence is flanked by two CR sequences at both ends of the HL sequence.

16. The method of any one of claims 13-15, wherein only a subset of the one or more DNA fragments comprise the HL or CR sequence.

17. The method of any one of claims 1-16, wherein the one or more DNA
fragments further comprise one or more DNA sequences encoding one or more antigens, subunits, or fragments thereof or other heterologous DNA sequences.

18. The method of claim 17, wherein two or more DNA fragments comprise the DNA sequence of the same antigen, a subunit or fragment thereof or the same heterologous DNA sequence.

19. The method of claim 17, wherein two or more DNA fragments comprise the DNA sequences of different antigens, subunits, or fragments thereof or other heterologous DNA sequences.

20. The method of any one of claims 17-19, wherein the DNA sequences of the antigens, subunits, or fragments thereof or other heterologous DNA
sequences are codon optimized for expression in the host cell.

21. The method of any one of claims 17-20, wherein the one or more DNA
fragments further comprise a virus promoter upstream of the DNA sequences of the antigens, subunits, or fragments thereof or other heterologous DNA sequences, a transcription termination signal downstream the DNA sequences of the antigens, subunits, or fragments thereof or other heterologous DNA sequences, or both.

22. The method of any one of claims 17-21, wherein the DNA sequences encoding the antigens, subunits, or fragments thereof or other heterologous DNA
sequences are inserted in one or more poxvirus insertion sites or intergenic regions.

23. An expression system comprising:
(i) a single DNA fragment comprising the entire genome of a desired poxvirus, or two or more DNA fragments each comprising a partial sequence of the genome of the desired poxvirus such that the two or more DNA fragments, when expressed in the host cell upon co-transfection, are assembled sequentially and comprise the full-length sequence of the poxvirus genome and enable reconstitution of a desired recombinant poxvirus, and (ii) one or more DNA sequences encoding one or more antigens, subunits, or fragments thereof or other heterologous DNA sequences inserted in one or more insertion sites of the poxvirus, wherein the antigens or subunits thereof or other heterologous DNA sequences are expressed in the host cell upon transfection of the one or more poxvirus DNA fragments and reconstitution of the poxvirus.

24. The expression system of claim 23, wherein the one or more DNA
fragments are circularized before transfection or transfected in circular forms into the host cell.

25. The expression system of claim 24, wherein the one or more DNA
fragments are cloned into a plasmid or a BAC vector.

26. The expression system of claim 23, wherein the one or more DNA
fragments are linearized before transfection or transfected in linearized forms into the host cell.

27. The expression system of any one of claims 23-26, wherein the one or more DNA fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments.

28. The expression system of any one of claims 23-27, wherein the genomic sequence of the poxvirus comprises the sequence of MVA Accession No.
#U94848 or #AY603355.

29. The expression system of any one of claims 23-28, wherein the two adjacent DNA fragments have an overlapping sequence to facilitate homologous recombination.

30. The expression system of claim 29, wherein the overlapping sequence is between about 100 bp and about 5000 bp in length.

31. The expression system of any one of claims 23-30, wherein the one or more DNA fragments further comprise an inverted terminal repeat (ITR) region.

32. The expression system of any one of claims 23-31, wherein the one or more DNA fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genome resolution (CR) sequence, or both, wherein the HL
or the CR sequence is added to one both ends of the DNA fragment as single stranded or double stranded DNA sequences in sense or antisense orientation.

33. The expression system of claim 32, wherein the one or more DNA
fragments further comprise one or more HL sequences and one or more CR
sequences.

34. The expression system of claim 33, wherein each HL sequence is flanked by two CR sequences at both ends of the HL sequence.

35. The expression system of any one of claims 32-34, wherein only a subset of the one or more DNA fragments comprise the HL or CR sequence.

36. The expression system of any one of claims 23-35, wherein the one or more DNA fragments further comprise a virus promoter upstream the DNA
sequences encoding the antigens, subunits or fragments thereof or other heterologous DNA sequences, a transcription termination signal downstream of the DNA sequences encoding the antigens, subunits or fragments thereof or other heterologous DNA sequences, or both.

37. The expression system of any one of claims 23-36, wherein the DNA
sequences encoding one or more antigens, subunits or fragments thereof or other heterologous DNA sequences are inserted in one or more poxvirus insertion sites.

38. A vaccine composition for preventing or treating cancer or a virus infection comprising:
(i) a single DNA fragment comprising the entire genome of a desired poxvirus, or two or more DNA fragments each comprising a partial sequence of the genome of the desired poxvirus such that the two or more DNA fragments, when transferred in the host cell upon co-transfection, are assembled sequentially and comprise the full-length sequence of the poxvirus genome, and (ii) one or more DNA sequences encoding one or more antigens, subunits, or fragments thereof or other heterologous DNA sequences inserted in one or more insertion sites of the poxvirus, wherein the antigens, subunits or fragments thereof or other heterologous DNA sequences are expressed in the host cell upon transfection of the one or more poxvirus DNA fragments.

39. The vaccine composition of claim 38, wherein the antigens, subunits or fragments thereof or other heterologous DNA sequences are inserted in one or more poxvirus insertion sites.

40. The vaccine composition of claim 38 or claim 39, further comprising a pharmaceutically acceptable carrier, adjuvant, additive or combination thereof.

41. A method of preventing or treating cancer or a viral infection in a subject comprising administering a prophylactically or therapeutically effective amount of a vaccine composition to the subject, wherein the vaccine comprises:
(i) a single DNA fragment comprising the entire genome of a desired poxvirus, or two or more DNA fragments each comprising a partial sequence of the genome of the desired poxvirus such that the two or more DNA fragments, when transferred in the host cell upon co-transfection, are assembled sequentially and comprise the full-length sequence of the poxvirus genome, and (ii) one or more DNA sequences encoding one or more antigens, subunits or fragments thereof or other heterologous DNA sequences inserted in one or more insertion sites of the poxvirus, wherein the antigens, subunits, or fragments thereof or other heterologous DNA sequences are expressed in the host cell upon transfection of the one or more poxvirus DNA fragments.

42. The method of claim 41, wherein the antigens, subunits, or fragments thereof or other heterologous DNA sequences are inserted in one or more poxvirus insertion sites.