KR20220146449A - Aerosol-generating substrate for vaping comprising semi-solid substrate - Google Patents

Abstract

The present invention relates to an aerosol-generating substrate for vaping, comprising a semi-solid substrate, wherein up to about 1.0% by weight of the total weight percentage of the aerosol-generating substrate consists of one or more carboxylic acids dissolved in an alcoholic solution. The present invention also relates to a method of manufacturing an aerosol-generating substrate and its use in an aerosol-generating substrate for vaping.

Description

Aerosol-generating substrate for vaping comprising semi-solid substrate

The present invention relates to an aerosol generating substrate and a method of making the same. The present invention also relates to an aerosol-generating article comprising an aerosol-generating substrate.

Recently different types of aerosol-generating articles and devices thereof for use as new forms of smoking are increasing rapidly and are commercially available on the market. These include one of the most well-known new forms of e-cigarettes (vaping) in which an aerosol is electrically heated, wherein the aerosol is generated by the transfer of heat from the heating element of the aerosol-generating device to the aerosol-generating substrate or material.

It has been reported that in non-burning heated aerosol-generating articles, the aerosol-forming substrate is heated at rather relatively low temperatures, for example below 350° C., in order to prevent its combustion. The explosive of an inhalable aerosol may then be released from the aerosol-generating article. The released aerosol originates from an aerosol former, comprised in the tobacco material, which may be particulate or granulated.

Some of the tobacco mixtures, especially those provided in the form of e-juice, often cause coughing (also known as cough attacks) during vaping. One of the reasons for these cough attacks is probably due to the fact that e-cigarettes have very different inhalation methods compared to most cigarette smokers. Some irritants present in the e-liquid can also cause cough attacks.

Accordingly, it would be desirable not only to provide a solution to overcome the above-mentioned problems, but also to provide an alternative that could deliver a more pleasant smoking and/or vaping experience.

In a further aspect, it is also an object of the present invention to provide a solution for improving the sensory properties of the above-mentioned consumables.

The inventors of the present invention have found a solution to the problem discussed above through an aerosol generating substrate for an aerosol generating article.

Accordingly, a first aspect of the present invention is to provide an aerosol-generating substrate for vaping comprising a semi-solid substrate, wherein up to about 1.0% by weight of the total weight percentage of the aerosol-generating substrate consists of a carboxylic acid-containing alcohol solution, wherein at least one The carboxylic acid is dissolved in an alcohol solution and a semi-solid substrate is provided in the form of a foam.

Accordingly, a second aspect of the present invention is to provide a method for preparing an aerosol-generating substrate for vaping comprising a semi-solid substrate in the form of a foam, the method comprising:

a. providing an aerosol generating substrate comprising at least one component selected from the list consisting of propylene glycol, 1,3-propanediol, glycerol and water;

b. providing at least one carboxylic acid to the alcoholic solution such that up to about 1% by weight of the total weight percentage of the aerosol-generating substrate consists of the at least one carboxylic acid-containing alcohol solution, followed by inclusion of the at least one carboxylic acid-containing alcohol solution in the aerosol-generating substrate; forming a mixture;

c. optionally adding to the mixture one or more components selected from the list consisting of gum, nicotine, flavoring and binding agents;

d. constantly mixing the mixture for a specified amount of time and heating the mixture slightly above room temperature, thus producing a semi-solid substrate in the form of a foam.

A third aspect of the present invention is to provide an aerosol generating substrate according to the present invention for use in reducing cough attacks from vaping.

A fourth aspect of the present invention is to provide an aerosol-generating substrate obtainable according to the present invention.

The inventors have found that the aerosol-generating substrate according to the invention is dissolved in an alcohol solution because of a small amount of carboxylic acid (up to 1.0% by weight of the total weight percentage of the aerosol-generating substrate consists of one or more carboxylic acid-containing alcohol solutions, and the aerosol-generating substrate is a foam or (including semi-solid substrates provided in the form of tobacco mousse), it has been found that the aerosol generating substrates according to the present invention unexpectedly reduce cough attacks to an acceptable level. In addition, it was also found that the taste was softened without any negative taste. This effect of reducing cough attacks is particularly pronounced when one or more carboxylic acids, such as stearic acid and/or decanoic acid, are present in an aerosol generating base alcoholic solution.

According to some embodiments, the aerosol-generating substrate comprises from 0.2% to 1% by weight of a carboxylic acid-containing alcohol solution, based on the total weight percentage of the aerosol-generating substrate, preferably about 0.2% by weight of the total weight percentage of the aerosol-generating substrate, 0.5%, 0.8%, or 1.0% by weight of a carboxylic acid-containing alcohol solution. This range or amount of carboxylic acid present in the mixture is sufficient to reduce irritation of a sore throat/cough attack to an acceptable level.

According to some embodiments, the carboxylic acid-containing alcohol solution is from about 0.05 v/v% to about 0.2 v/v%, preferably from 0.08 v/v% to 0.15 v/v%, or more preferably from 0.1 v/v % of the concentration. Concentrations as used herein may be given as volume percentage concentrations, eg, (v/v%), molar concentrations, or as mass percentage concentrations.

According to some embodiments, the carboxylic acid has a hydrocarbon chain length of 9 to 30 carbons, preferably 10 to 20 carbons.

According to some embodiments, the carboxylic acid is benzoic acid, levulinic acid, D/L-tartaric acid, capric acid, pyruvic acid, citric acid, fumaric acid, D/L-lactic acid, D/L-malic acid, sorbic acid, adipic acid, L -Aspartic acid, L-glutamic acid, succinic acid, gluconic acid, linoleic acid, sugar acid, 3,7 dimethyl-6-octhenic acid, 2-methyl pentanoic acid, trans-2-hexenoic acid, caprylic acid, lauric acid, stearic acid , butyric acid, linolenic acid, malonic acid, myristic acid, oleic acid, palmitic acid, phenylacetic acid, propionic acid, valeric acid, decanoic acid, hexanoic acid and octanoic acid.

According to some embodiments, the carboxylic acid-containing alcohol solution contains only saturated fatty acids such as stearic acid and/or decanoic acid, preferably 10/90, 20/80, 30/70, 40/60, stearic acid/decanoic acid, It is included in a ratio of 50/50.

According to some embodiments, the carboxylic acid-containing alcohol solution comprises only stearic acid or decanoic acid.

According to some embodiments, the alcoholic solution comprises only stearic acid and decanoic acid, preferably in a ratio of 10/90, 20/80, 30/70, 40/60, 50/50 of stearic acid/decanoic acid. The inventors have found that these two compounds are particularly effective in suppressing sore throat irritation, and a ratio of 20/80 to 50/50 of stearic acid/decanoic acid is particularly effective in reducing cough attacks.

According to some embodiments, the aerosol generating substrate further comprises one or more components selected from the group consisting of propylene glycol, 1,3-propanediol, glycerol, water, gums, flavorings, additives, nicotine and binders.

According to some embodiments, the solvent has a pH value in the range of 6 to 7, preferably 6.2 to 6.8, more preferably 6.3 to 6.5. In other embodiments, for example, an acidic state of 4 to 6.9 is preferred.

According to some variations, the carboxylic acid-containing alcohol solution is prepared, for example, by weighing the components (eg, a solvent, a solute in solid or liquid form), mixing the mixture in a bottle, and allowing the solute to dissolve completely in the solvent It can be prepared by allowing the mixture to stand at room temperature for at least 24 hours to ensure that the mixture is mixed prior to use in the final production of the foam.

According to some embodiments, the mixture is heated at approximately 45° C. and/or aerated or mixed for approximately 5 minutes.

According to another embodiment, the aerosol generating substrate in the form of a foam, for example,

- by preparing a mixture of an aerosol generating substrate comprising propylene glycol, glycerin, water and a 0.1% carboxylic acid-containing alcohol solution;

- by mixing the mixture at 45° C. for 6 minutes (eg in a Krups machine at speed “6”);

- by adding the gum (preferably within 1 minute) and further mixing at 45° C. for 6 minutes (eg at speed “6” in a Krups machine);

- by adding the tobacco-containing material (preferably within 2 minutes) and mixing the mixture further at 45° C. for 6 minutes (eg at speed “6” in a Krups machine);

- by adding binder (preferably within 1 minute) and mixing the mixture further at 45° C. for 5 minutes (eg at speed “6” in a Krups machine);

- by filling a foamed aerosol generating substrate into a mold and heating it in an oven at about 50° C. for about 18 hours.

"About" or "approximately" in relation to a given numerical value means that the numerical value includes within 10% of the stated value. All values given in this disclosure are understood to be supplemented by the word “about” unless the context clearly indicates to the contrary. In more restrictive terms, the term is used to include numerical values within 5% of the stated value.

The singular expression does not exclude the plural and therefore should be treated broadly.

Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

Tobacco-containing material is any compound that contains and/or carries components of tobacco, such as tobacco, tobacco particles, tobacco flavor and/or nicotine, which are artificially or naturally included in tobacco; It may be a mixture, a particulate material and/or a solution. In contrast, an example of a flavor not specific to tobacco added artificially would be menthol.

As used herein, the term "aerosol-generating article" refers to an aerosol-generating article for generating an aerosol comprising an aerosol-generating material that is intended to be heated rather than combusted to release a volatile compound capable of forming an aerosol.

As used herein, the term “aerosol-generating substrate” refers to a material capable of releasing volatile compounds that, upon heating, can form an aerosol. Aerosols generated from the aerosol-generating material of an aerosol-generating article described herein may be visible or invisible, and may be vapor (e.g., fine particles of a substance that are in a gaseous state, usually liquid or solid at room temperature). as well as liquid droplets of gas and condensed vapor.

The aerosol former may be, for example, any compound, mixture and/or solution capable of forming an aerosol when heated and/or mixed with a tobacco-containing agent. Well-known examples include wetting agents such as glycerin and propylene glycol, other alcohols such as ethanol, and the like.

As used herein, the term “semi-solid substrate” refers to the state of a substrate that is highly viscous and slightly thicker than semi-fluid. That is, the semi-solid substrate does not contain a solid material (ie, a rigid, stable shape) or liquid or fluid. Examples of "semi-solid substrates" in the present invention are, for example, foams, gels, mousses or thick mucus.

As used herein, the terms "foam" or "mousse" are used interchangeably. In the present case, a foam refers to an element comprising pockets of air or gas entrapped in a liquid or non-solid material. For example, open pore foams can contain a plurality of interconnected pores (such as foam stabilizers, solid components such as tobacco particles, and some solvents, etc. is understood as a foam that may be considered to be formed from a structural material originating from a foam former that cooperates with an interacting component), wherein at least a significant portion (e.g., greater than 50% by volume) of the pores in the foam are closed cells. In contrast to foams, they are fluidly interconnected and most of the pores form separate pockets, each completely surrounded by a pore-forming material to substantially prevent fluid from passing freely between the pores. After cooling or heating of the aerosol-generating material, vapor is released from the mousse based on the weight measurements of the mousse portion before and after heating, and it appears that substantially all of the wetting agent is released, which means that the wetting agent migrates through the neighboring pores and causes the mass of the mousse portion. It is currently believed that the mousse formed as described herein is mostly open pore mousse, since it cannot be easily described if it cannot reach the surface. However, alternative explanations cannot be completely ruled out - for example, the closed cell wall may rupture due to the pressure of vaporized gas, etc., thereby opening the closed pores.

As referred to in the present invention, electronic cigarettes (e-cigarettes) or similar devices such as electronic pipes or non-burning heating devices are not particularly limited and may be used to provide the user with an inhalable aerosol. According to a particular embodiment, this may include a mouthpiece, a heater, a receptacle such as a pod, a stick, a capsule and a casing.

As used herein, weight percent is understood as a weight percentage based on the total weight percentage of the aerosol generating substrate, unless expressly specified otherwise. In the present disclosure, all amounts are given in weight percent, unless explicitly stated otherwise or clear from context. In the present disclosure, all amounts also given in weight percent add up to 100 weight percent. Hereby, unless indicated otherwise or otherwise clear from context, weight percentages are calculated by dividing the mass of each component by, for example, the total mass of the substrate. Thus, in the present case, the chemical compounds can also be applied in volume percentages that are within the common ability of those skilled in the art.

As used herein, volume percent is understood as a percent volume based on the total volume of the substrate, unless expressly stated otherwise. In the present disclosure, all amounts given in vol % in a particular substrate add up to 100 vol %. Hereby, unless indicated otherwise or otherwise clear from context, volume percentages are calculated by dividing the volume of each component by the total volume of the substrate.

Similarly, the aeration value (also known as pore volume as used herein) represents the volume percent of a foam or mousse composed of air. The actual aeration value of the sample was estimated using the following procedure: preparing a sample of the "foam" without taking any action to aerate the "foam" (e.g., whipping or aeration using an aeration machine); The known volume of this unfoamed "foam"/material is measured. A sample of the foam is then prepared after performing an aeration step (eg, a step such as agitation or aeration using an aeration machine) and the aerated foam of the same known volume is weighed again and the percent reduction in weight is calculated. By assuming that the aeration of the unfoamed material is zero and that the weight of the air is negligible, it is a direct estimate of the aeration value by assuming that the decrease in the measured weight is the result of replacing the unfoamed material with (weightless) air. do. For example, if 4% less weight is observed for a foamed material of the same volume compared to the volume of the unfoamed material, it is assumed that 4% of the unfoamed material is displaced by air It means that the volume % is 4%.

As disclosed herein, particle size may be measured by any suitable method, for example by sieving or laser diffraction, preferably by sieving.

The (dynamic) viscosity described herein describes the flow behavior of a liquid. It is defined as the internal frictional resistance of a liquid to the application of pressure or shear stress. Kinematic viscosity is given in milliPascal-seconds (mPas) and is determined using a rotational viscometer. Viscosity measurement is performed at room temperature, that is, 22°C.

As used herein, “cooling” refers to a temperature at room temperature (about 22-24° C.) for at least 60 minutes, or a temperature below 16° C. for at least 10 minutes, or more preferably at a temperature below 12° C. for at least 5 minutes. is understood to have

As used herein, "aeration" is understood as the introduction of air or gas into a material, through an external step. Aeration is performed, for example, by agitation, beating, mixing or by means of an aeration machine, such as a Krups Prep & Cook HP 5031 mousse agitation shuffle or by injection air using an aeration device such as, for example, a Mondomix aerator. This can be done through aeration. Aeration can be carried out at any suitable temperature. The duration of the aeration may be, for example, 1, 2, 3, 4, 5 or 10 minutes or longer.

The present invention relates to improved aerosol-generating substrates and methods of producing the aerosol-generating substrates of the present invention. When the aerosol-generating (tobacco-containing) substrate of the present invention comprises at most 1.0% by weight carboxylic acid (dissolved in the alcohol solution) out of the total weight percentage of the aerosol-generating substrate, the carboxylic acid-containing aerosol-generating substrate surprisingly produces a sore throat irritation or cough attack. was found to decrease.

A smoker's cough is a common disease among smokers, especially those new to e-cigarettes. Inhalation of vapors sometimes results in severe coughing attacks, i.e. irritations that cause coughing urges when inhaling an aerosol produced by heating of the substrate. There can be a number of factors that can cause these cough attacks. For example, some smokers may be affected by the pure nicotine in e-cigarettes, or inhale too deeply or too quickly to cause a cough, or the vaporizer's advanced settings are not fine-tuned accordingly.

Tobacco-based aerosols (close to the so-called "pharyngitis relief" desired by cigarette smokers, but not observed in e-cigarette aerosols) may have a slight sore throat irritation, but the actual cough urge during combustion of e-vaping materials such as tobacco mousse bases. It is necessary to control the irritation induced by aerosols to prevent

In the present case, the inventors have investigated possible alternative formulas of aerosol generating substrates, which are specifically aimed at reducing cough attacks. The inventors have found that when up to about 1.0% of the total weight percentage of the aerosol generating substrate consists of one or more carboxylic acids in an alcoholic solution, a surprising effect of reducing cough attacks (or reducing sore throat irritation) is observed.

It is also found herein that when the aerosol-generating substrate comprises a semi-solid substrate, for example, when the aerosol-generating substrate is provided in the form of a semi-solid substrate such as a foam or mousse form or in the form of a gel, a reduction in cough attacks was particularly evident. is initiated. When the aerosol-generating substrate comprising a carboxylic acid (especially comprising, for example, stearic acid and/or decanoic acid) is in a semi-solid state, i.e., a foam or a gel, a higher surface-to-volume ratio is that the aerosol-generating substrate is in liquid or solid form. It is believed to cause the carboxylic acid to be vaporized or released more efficiently compared to when provided as

In the present invention, the foam stabilizer may additionally be incorporated into the aerosol-generating substrate. The foam stabilizer is not particularly limited as long as it can stabilize the foam to some extent after formation. According to a particular embodiment, the foam stabilizer of the present foam is selected from the group consisting of cellulose gums, hydroxyalkylated carbohydrates, and mixtures thereof. Neither the cellulose gum nor the hydroxyalkylated carbohydrate is particularly limited. According to a particular, preferred embodiment, the foam stabilizer is a cellulose gum, in particular carboxymethylcellulose, or a derivative thereof. Exemplary preferred cellulosic gums that may be used in the present invention are CEKOL® 2000 and/or Ceroga 4550C (C.E. Roeper GmbH), purified sodium carboxymethylcellulose, respectively. Another class of suitable foam stabilizers are hydroxyalkylated carbohydrates, and more preferably cellulose ethers and derivatives thereof. Cellulose ethers or derivatives thereof that can be used may have at least one substituent selected from the group consisting of a methyl group, an ethyl group, a hydroxyethyl group and a hydroxypropyl group. It may be further substituted with a linear or branched, substituted or unsubstituted alkyl radical having 1 to 20 carbon atoms or an aralkyl radical having 7 to 20 carbon atoms. These radicals are preferably attached by ether bonds. Suitable substituents may be, for example, hydroxy groups, carboxy groups having 1 to 4 carbon atoms, and the like. According to a particular embodiment, the cellulose ether is selected from hydroxyethylcellulose, methylcellulose, methylhydroxyethylcellulose, ethylhydroxyethylcellulose, and mixtures thereof. Furthermore, mixtures of different cellulose gums, mixtures of different hydroxyalkylated carbohydrates, and mixtures of one or more cellulose gums with one or more hydroxyalkylated carbohydrates, as well as derivatives of one or each of these may be used. Also included as derivatives are these salts of cellulose ethers, preferably their alkali metal salts, for example their sodium and/or potassium salts.

Similarly, a foam former may additionally be added to the mixture of the aerosol generating substrate. In addition, the foam former is not particularly limited. According to a particular embodiment, the foam former of the foam of the present invention is selected from the group consisting of agar, gellan gum, lecithin, polyglycerol esters of fatty acids, glycerol esters of fatty acids, sorbitan esters of fatty acids, and/or mixtures thereof. However, it is not limited thereto. A preferred foam former is gellan gum. Glycerol esters can be prepared by standard esterification methods. When glycerol esters of fatty acids are used, the foam former may suitably be compounds such as glycerol monostearate and/or glycerol monooleate. Polyglycerol esters can be prepared by polymerizing glycerin under alkaline conditions and then suitably reacting it with specific fatty acids. Suitable polyglycerol esters may be hexaglycerol monooleate, octaglycerol monostearate and/or octaglycerol monooleate. The sorbitan esters of fatty acids used in certain embodiments of the invention may be sorbitan monostearate, sorbitan monooleate and/or sorbitan monopalmitate. Furthermore, any possible combination of compounds belonging to the above-mentioned classes may be used.

The method may also be realized by carrying out the steps of mixing the aerated aerosol-generating substrate after addition of the foam stabilizer and/or after cooling of the mixture. This does not exclude that other aeration steps are also carried out, according to a particular embodiment, one, two or preferably all optional aeration steps are carried out in the process of the invention. Furthermore, it is not excluded that aeration is already carried out simultaneously with the mixing and/or addition step.

The method of aeration is not particularly limited, for example, injection of air, mixing of air - for example by means of a sufficiently large paddle/shuffle and/or sufficient paddle movement and/or sufficient so that air can be introduced into the mixture. at a slower rate, such as bubbling air through the mixture. For example, aeration can be done using a sufficient mixing machine similar to a mixer for making the mousse, for example, a Krups Prep & Cook HP 5031 Mousse Stirring Shuffle and/or by means of an aerator, such as, for example, a Mondomix aerator. This can be done by injection air. Aeration can be carried out at a suitable temperature, for example at room temperature (about 20 to 24° C.), from 30 to 80° C., for example from 35 to 75° C., preferably from 30 to 60° C. In the present process, it is not excluded that aeration is carried out simultaneously with mixing and/or in the step of adding components, for example when using stirring.

To this end, using the method described above, to an aerosol-generating substrate as presently claimed, even without additionally adding foam formers and/or foam stabilizers, the mixture of the aerosol-generating substrate is in a semi-solid state, It is emphasized that it can be transformed into a foam, mousse, gel, and the like. That is, the aerosol-generating substrate of the present invention is a semi-solid substrate.

According to some embodiments of the present invention, ingredients for forming an aerosol-generating foam, such as an aerosol former, a foam former, a foam stabilizer, a tobacco-containing formulation, an inhalable formulation, at least one non-tobacco flavor and a solvent, are It is not particularly limited. In addition, the gas used for aeration is not particularly limited, and may be, for example, air. Additional components may also be mixed. According to certain embodiments, the further components are nevertheless immiscible or essentially immiscible.

The aerosol former may further comprise water. According to a particular embodiment, no water is included nonetheless, since water in the form of an aerosol can burn the user's mouth. Water may be included in an amount of 0 to 15% by weight, for example 5 to 10% by weight of the total weight percentage of the foam or aerosol generating substrate.

Example

Example 1

The present invention will now be described in detail with reference to examples thereof. However, this example serves for illustrative purposes only and does not limit the scope of the present invention.

Table 1 shows that tobacco mousse (foam) comprising alcohol solutions containing different weight percentages of carboxylic acids (ie, stearic acid and decanoic acid) were studied. To produce the exemplary foam, the components provided in each row of Table 1 were mixed and combined as follows.

Equal amounts of stearic acid and decanoic acid were used in all samples, and this carboxylic acid was dissolved in an alcohol solution. Due to their chemical similarity, it is believed that both stearic acid and decanoic acid may be used interchangeably or may be used interchangeably. The carboxylic acid-containing alcohol solution has a concentration of 0.1%.

First, a solution of propylene glycol, glycerin, carboxylic acid alcohol (containing equal amounts of stearic acid and decanoic acid) and optionally purified water using a Krups Prep & Cook HP5031 mousse stirring shuffle at 45° C. for 5 to 10 minutes, preferably Stirred for 6 minutes and aerated. When stirring the mousse, the speed must be adjusted so that the volume increases visually and small bubbles appear and partially stay in the foam. If the agitation is too fast, mixing will occur and the foam structure will collapse and return to the fluid. As one option, start stirring slowly and increase the stirring speed slowly as the foam begins to exhibit a lighter, more mousse-like texture; If the mousse reduces its mousse-like texture and appears less aerated on the surface, reduce its speed by about 10%. In order to preserve the foam structure to create a stable fraction, quenching with ice or cold water is recommended. With the Krups device mentioned above, the best results can be obtained at speeds between 60 and 200 rpm. Adjustments are within the knowledge of those skilled in the art according to the above description.

In the next step (within 1 minute of the previous step), the gum was added and the mixture was stirred using a Krups Prep & Cook HP5031 mousse stirring shuffle at 45° C. for 5-10 minutes, preferably 6 minutes and aerated . Then tobacco powder was added and stirring and aeration were carried out using the same method at 45° C. for 5 to 10 minutes, preferably 6 minutes. Next, binder was added and the mixture was stirred again using the same method at 45° C. for 5-10 minutes, preferably 6 minutes and aerated. Finally, the mixture was packaged and placed in an oven at 50° C. for 12 hours before ready to use.

Since no international standard of "perceptual assessment" for cough attacks is available, the scoring of "perceptual assessment" for cough attacks is performed as described below. The results obtained from Example 1 are shown in Table 2.

To establish an average cough attack score, sample 1 (with no carboxylic acids in the consumables) was given first to the test subjects to be scored. Each test subject inhaled 10 puffs within 3 minutes and the degree of sore throat irritation was measured (score 100 is highly stimulated; score 60 moderately stimulated; score 30 slightly stimulated; score 0 not stimulated). After sample 1 was measured, samples 2, 3, 4 and 5 were given to test subjects in random order. This procedure was repeated similarly to the control sample (Sample 1). Cough seizure scores were measured by test subjects based on their perception of sore throat irritation. A pause of 60 seconds (or 120 seconds) is provided before a new sample is presented to the test subject.

As can be seen in Table 2, samples 2, 3, 4 consisted of 0.2%, 0.5%, 0.8% and 1.0% by weight of a carboxylic acid-containing alcohol solution, respectively, of the total weight percentage mixture of the aerosol-generating substrate. and 5 had lower mean cough attack scores compared to the control sample (Sample 1). As an example, the total weight of sample 1 (0 wt % stearic acid and decanoic acid) is 500 g.

Sample 1 (control sample) without any carboxylic acid (fatty acid) had the highest mean cough attack score (71.25). The aerosol-generating substrate comprising 0.2% by weight and 1.0% by weight of a carboxylic acid-containing alcohol solution based on the total weight percentage of the aerosol-generating substrate scored significantly lower compared to Control Sample 1, i.e., less than 40, i.e., Sample 2 , 3, 4 and 5 were observed to have 36.25, 33, 39 and 37, respectively. This value indicates that only slight sore throat irritation or cough attacks were observed in samples 2-5, as reported by various test subjects.

In addition, in addition to reduced cough seizures as measured by the test subject, in samples comprising up to 1% by weight of carboxylic acid-containing alcohol based on the total weight percentage of the aerosol generating substrate, as observed in Sample 1, taste It was also reported that it was softer and did not have any negative taste.

Although the lowest amount of carboxylic acid-containing alcohol contained in the aerosol-generating substrate carried out in the experiments was 0.2% by weight based on the total weight percentage of the aerosol-generating substrate, 0.1% or 0.05% by weight, based on the total weight percentage of the aerosol-generating substrate The same lower dose is believed to be equally effective in suppressing sore throat irritation or reducing cough attacks.

To this end, it is reiterated that this surprising effect of the present invention is only observed on certain semi-solid substrates (foams, mousses, gels, mucilages) and is not applicable in solid or liquid media.

The present foam according to the invention is not smoked, ie is not heated to the temperature at which the foam burns, but only at least a part thereof, in particular at least essentially of an aerosol former and more preferably of a tobacco-containing preparation and/or an inhalable preparation. It is applied in such a way that at least part of it is evaporated. In the present foam, at least a portion of the tobacco-containing preparation and/or inhalable preparation is preferably absorbed essentially by and/or adhered to the foam structure formed of the foam former and the foam stabilizer, so that upon heating the aerosol It can be easily released together with the former. In addition, some portion of the tobacco-containing formulation and/or inhalable formulation is bound to the foam structure and the tobacco-containing formulation and/or inhalable formulation are "extracted" during its heating, so that the tobacco-containing formulation and/or inhalable formulation are bonded to the foam structure. It is possible that the perfume from According to a particular embodiment, the tobacco component-containing formulation and/or the inhalable formulation are configured in such a way that they are released together with the aerosol former upon heating by only being essentially adsorbed and/or absorbed in the foam structure. In this regard, it has been found by the inventors that a mass loss in the foam can be observed, essentially indicating that at least the mass of the foam former and foam stabilizer is maintained. It is assumed that the structure of the foam is formed mainly by the foam former, which forms an "encapsulation" for adhering and/or absorbing the aerosol former and the tobacco component containing formulation and/or the inhalable formulation, Foam stabilizers stabilize the foam to maintain its foam shape.

Claims (15)

An aerosol-generating substrate for vaping, comprising a semi-solid substrate, wherein up to about 1.0 weight percent of the total weight percentage of the aerosol-generating substrate consists of a carboxylic acid-containing alcohol solution, wherein at least one carboxylic acid is dissolved in the alcohol solution, and wherein the semi-solid An aerosol-generating substrate, wherein the substrate is provided in the form of a foam. 2 . The aerosol-generating substrate according to claim 1 , wherein the aerosol-generating substrate comprises from 0.2% to 1% by weight of the carboxylic acid-containing alcohol solution of the total weight percentage of the aerosol-generating substrate, preferably about 0.2% by weight of the total weight percentage of the aerosol-generating substrate. %, 0.5%, 0.8% or 1.0% by weight of said carboxylic acid-containing alcohol solution. 3. The carboxylic acid-containing alcohol solution according to claim 1 or 2, wherein the carboxylic acid-containing alcohol solution is from about 0.05 v/v% to about 0.2 v/v%, preferably from 0.08 v/v% to 0.15 v/v%, or more preferably is an aerosol-generating substrate having a concentration of 0.1 v/v%. 4 . The aerosol generating substrate according to claim 1 , wherein the carboxylic acid has a hydrocarbon chain length of from 9 to 30 carbons, preferably from 10 to 20 carbons. 5. The method of any one of claims 1 to 4, wherein the carboxylic acid is benzoic acid, levulinic acid, D/L-tartaric acid, capric acid, pyruvic acid, citric acid, fumaric acid, D/L-lactic acid, D/L-malic acid , Sorbic acid, adipic acid, L-aspartic acid, L-glutamic acid, succinic acid, gluconic acid, linoleic acid, sugar acid, 3,7 dimethyl-6-octhenic acid, 2-methylpentanoic acid, trans-2-hexenoic acid, car priylic acid, lauric acid, stearic acid, butyric acid, linolenic acid, malonic acid, myristic acid, oleic acid, palmitic acid, phenylacetic acid, propionic acid, valeric acid, decanoic acid, hexanoic acid and octanoic acid, aerosol-generating substrates. 6 . The aerosol-generating substrate according to claim 1 , wherein the carboxylic acid-containing alcohol solution comprises only saturated fatty acids such as stearic acid and/or decanoic acid. 7. The alcohol solution according to any one of the preceding claims, wherein the alcoholic solution contains only stearic acid and decanoic acid, preferably 10/90, 20/80, 30/70, 40/60, 50 of stearic acid/decanoic acid. an aerosol generating substrate comprising a ratio of /50. 8. The aerosol-generating substrate according to any one of the preceding claims, wherein the carboxylic acid-containing alcohol solution comprises only stearic acid or decanoic acid. 9. The aerosol generating substrate according to any one of claims 1 to 8, wherein the aerosol generating substrate comprises at least one selected from the group consisting of propylene glycol, 1,3-propanediol, glycerol, water, gums, flavorings, additives, nicotine and binders. An aerosol generating substrate comprising an element. 10. An aerosol generating substrate according to any one of claims 1 to 9 for use in reducing cough attacks from vaping. An aerosol-generating article comprising an aerosol-generating substrate according to claim 1 . A method of making an aerosol-generating substrate for vaping comprising: a semi-solid substrate in the form of a foam;
a. providing an aerosol generating substrate comprising at least one component selected from the list consisting of propylene glycol, 1,3-propanediol, glycerol and water;
b. at least one carboxylic acid is provided to an alcoholic solution such that up to about 1% by weight of the total weight percentage of the aerosol-generating substrate consists of the at least one carboxylic acid-containing alcohol solution, followed by adding the at least one carboxylic acid-containing alcohol solution to the aerosol incorporation into the resulting substrate to form a mixture;
c. optionally adding to the mixture one or more components selected from the list consisting of gum, nicotine, flavoring and binding agents;
d. constantly mixing the mixture for a specified amount of time and heating the mixture slightly above room temperature to produce the semi-solid substrate in the form of a foam. 13. The method of claim 12, wherein the carboxylic acid-containing alcohol solution is from about 0.05 v/v% to about 0.2 v/v%, preferably from 0.08 v/v% to 0.15 v/v%, or more preferably 0.1 v/v%. having a concentration of v%. 14. The method of claim 12 or 13, wherein the mixture is heated at approximately 45° C. and/or aerated or mixed for approximately 5 minutes. 15. An aerosol generating substrate obtainable according to any one of claims 12 to 14.