KR20220143875A - G12v 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체 - Google Patents

G12v 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체 Download PDF

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KR20220143875A
KR20220143875A KR1020227031589A KR20227031589A KR20220143875A KR 20220143875 A KR20220143875 A KR 20220143875A KR 1020227031589 A KR1020227031589 A KR 1020227031589A KR 20227031589 A KR20227031589 A KR 20227031589A KR 20220143875 A KR20220143875 A KR 20220143875A
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acid sequence
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노암 레빈
마리아 알 파크허스트
3세 프랭크 제이 로어리
스티븐 에이 로젠버그
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더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/4244—Enzymes
    • A61K40/4253—GTPases, e.g. Ras or Rho
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KR1020227031589A 2020-02-14 2021-02-12 G12v 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체 Pending KR20220143875A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062976655P 2020-02-14 2020-02-14
US62/976,655 2020-02-14
US202063060340P 2020-08-03 2020-08-03
US63/060,340 2020-08-03
PCT/US2021/017852 WO2021163477A1 (en) 2020-02-14 2021-02-12 Hla class i-restricted t cell receptors against ras with g12v mutation

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KR20220143875A true KR20220143875A (ko) 2022-10-25

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KR1020227031589A Pending KR20220143875A (ko) 2020-02-14 2021-02-12 G12v 돌연변이를 갖는 ras에 대한 hla 클래스 i-제한된 t 세포 수용체

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US (1) US20230082787A1 (https=)
EP (1) EP4103598A1 (https=)
JP (1) JP7735285B2 (https=)
KR (1) KR20220143875A (https=)
CN (1) CN115315441A (https=)
AU (1) AU2021220957A1 (https=)
BR (1) BR112022015897A2 (https=)
CA (1) CA3167382A1 (https=)
GB (1) GB2610311B (https=)
MX (1) MX2022009825A (https=)
TW (1) TWI902755B (https=)
WO (1) WO2021163477A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL305393A (en) 2021-02-25 2023-10-01 Alaunos Therapeutics Inc Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
EP4334361A1 (en) 2021-05-05 2024-03-13 Immatics Biotechnologies GmbH Antigen binding proteins specifically binding prame
US20250145950A1 (en) 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
WO2023232785A1 (en) * 2022-05-30 2023-12-07 Hs Diagnomics Gmbh Common tumor-specific t cell receptors
CN118852452A (zh) * 2023-04-28 2024-10-29 北京鼎成肽源生物技术有限公司 靶向kras g12突变的tcr分子和细胞及其应用
WO2025056681A1 (en) * 2023-09-15 2025-03-20 Medigene Immunotherapies Gmbh T-CELL RECEPTOR AGAINST mKRAS7-16 G12V AND G12C

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
MX384919B (es) 2014-11-26 2025-03-14 Us Health Receptores de células t de kras anti-mutado.
JP7185524B2 (ja) * 2015-09-15 2022-12-07 アメリカ合衆国 Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体
US20170319638A1 (en) * 2016-05-06 2017-11-09 Virttu Biologics Limited Treatment of cancer
EP3684799A1 (en) 2017-09-20 2020-07-29 The U.S.A. as represented by the Secretary, Department of Health and Human Services Hla class ii restricted t cell receptors against mutated ras
EP3720478A1 (en) * 2017-12-04 2020-10-14 The United States of America, as represented by the Secretary, Department of Health and Human Services Hla class i-restricted t cell receptors against mutated ras
EP3731861A1 (en) * 2017-12-29 2020-11-04 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft T cell receptors for tumor specific proteasome splice variants and uses thereof

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Publication number Publication date
TW202140535A (zh) 2021-11-01
JP2023526149A (ja) 2023-06-21
GB2610311A (en) 2023-03-01
CN115315441A (zh) 2022-11-08
EP4103598A1 (en) 2022-12-21
US20230082787A1 (en) 2023-03-16
MX2022009825A (es) 2022-10-13
JP7735285B2 (ja) 2025-09-08
TWI902755B (zh) 2025-11-01
GB202211757D0 (en) 2022-09-28
WO2021163477A8 (en) 2022-09-29
GB2610311B (en) 2025-07-09
CA3167382A1 (en) 2021-08-19
AU2021220957A1 (en) 2022-09-01
BR112022015897A2 (pt) 2022-10-18
WO2021163477A1 (en) 2021-08-19

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