KR20220108628A - Food Composition For Improving Skin Elasticity Or Moisture - Google Patents

Abstract

The present invention provides a food composition for alleviating skin elasticity or moisturizing which comprises a ginseng extract and glue. The food composition of the present invention comprises a ginseng extract, which is a naturally derived extract, and glue to exhibit an effect of alleviating skin elasticity or moisturizing through ingestion. The food composition of the present invention exhibits an effect of alleviating elasticity or moisturizing by delivering active ingredients into the body and creating a healthy skin environment so that the food composition has an effect of fundamentally alleviating skin health compared to a conventional cosmetic composition.

Description

Food Composition For Improving Skin Elasticity Or Moisture

The present invention relates to a food composition for improving skin elasticity or moisture.

As the largest organ of our body, the skin occupies about 16% of the total volume of our body, and while in direct contact with the external environment, it functions to protect the human body from many harmful factors and external stimuli that try to invade the body. The skin consists of the epidermis including the cornified layer, which is the outermost layer, the dermis below it, and the hypodermis at the bottom.

Inner Beauty is a compound word of 'Inner' and 'Beauty', which means beauty. It means to take care of healthy skin from the inside of the human body. Interest in inner beauty is growing. The size of the domestic inner beauty market has grown tenfold in eight years from 50 billion won in 2011 to 500 billion won in 2019. It is expected that the market for products that are expected to be effective in moisturizing, elasticity, and pigmentation of the skin through consumption of these foods will continue to expand.

While most skin moisturizing cosmetics concentrate on the absorption of moisture and active ingredients in the stratum corneum, inner beauty materials are delivered to the body through the digestive system and blood vessels after ingestion to create a healthy skin environment, thereby creating a healthy environment for skin as well as the entire epidermis and dermis layer. It acts on the skin tissue of the skin and shows effects such as moisturizing and elasticity improvement. Research and development of these inner beauty materials are continuously being made.

Ginseng is a perennial, shady herbaceous plant belonging to the genus Panax of the Araliaceae family, and has been used as an important medicinal material in oriental medicine for a long time. The saponins of ginseng have anticancer activity, antioxidant activity, prevention of arteriosclerosis and high blood pressure, improvement of liver function, anti-fatigue, anti-stress activity, anti-aging, brain activity promotion, anti-inflammatory activity, treatment of allergic diseases, and promotion of protein synthesis ability. It is active, and Korean red ginseng is known to have excellent physiological activities such as antioxidant, blood pressure lowering, alcoholic hyperlipidemia improvement, and blood sugar lowering action.

Ginseng is generally divided into white ginseng and red ginseng according to the processing method. White ginseng refers to unprocessed ginseng mined in the field, that is, fresh ginseng as it is, and red ginseng is steamed and dried and processed by steaming fresh ginseng. Numerous chemical changes, such as amino acid changes, are involved. Red ginseng produces saponin components such as ginsenosides Rg2, Rg3, Rh1, and Rh2 that are not present in ginseng due to the heat applied during the manufacturing process. Excellent pharmacological efficacy can be expected as it has excellent anti-thrombotic, anti-oxidative, and anti-thrombotic properties, improving brain nerve cells and learning ability.

Glue (Colla Corii Asini) is prepared by heating animal-derived hides or bones in water to coagulate the extracted extract. The main component of glue is gelatin, and at room temperature, it is usually a blackish-brown solid. When water is added, it becomes a colloid, and when heated, it becomes a sol state.

無力), 심번불면(心煩不眠), 허풍내동(虛風內動), 폐조해수(肺燥咳嗽), 노수객혈(勞嗽喀血), 토혈뇨혈(吐血尿血), 변혈붕루(便血崩漏), 임신태루(妊娠胎漏)에 약재로서 쓰였다.Glue has been widely used in the private sector since ancient times. Glue derived from cattle or horses has adhesive strength and was used as an adhesive for wood, paper, and cloth. It is known to have excellent physiological effects such as bohyeol consonants, lubrication, and hemostasis, and it is known for its excellent physiological effects, such as hyeol-heo-wi-hwang (血虛)

Insomnia, heartburn, insomnia, flatulence, seawater exhaustion, hemoptysis, hematemesis in urine, discoloration , was used as a medicine for pregnancy taeru (妊娠胎漏).

The present inventors have completed the present invention by discovering the possibility of fundamentally improving skin health by using ginseng extract and glue while continuing research on a food composition that can exhibit the effect of improving skin elasticity or moisture.

Korean Patent Publication No. 10-1743572 (2017.05.30)

An object of the present invention is to provide a food composition comprising a naturally-derived extract that can exhibit an effect of improving skin elasticity or moisture.

One aspect of the present invention is a ginseng extract; and glue; as an active ingredient, providing a food composition for improving skin elasticity or moisture.

The food composition of the present invention can exhibit the effect of improving skin elasticity or moisture through ingestion by including ginseng extract and glue, which are naturally derived extracts. Since the food composition of the present invention exhibits an effect of improving elasticity or moisture by delivering an active ingredient into the body to create a skin health environment, it has an effect of fundamentally improving skin health compared to a cosmetic composition to be applied.

1 shows the procollagen synthesis effect of a complex of ginseng extract and glue.
Figure 2 shows the effect of improving skin moisturizing power after ingesting the food composition of the present invention for 8 weeks.
3 shows the skin elasticity improvement effect after ingesting the food composition of the present invention for 8 weeks.

Hereinafter, the present invention will be described in more detail to help the understanding of the present invention.

The terms or words used in the present specification and claims should not be construed as being limited to their ordinary or dictionary meanings, and the inventor may properly define the concept of the term in order to best describe his invention. Based on the principle that there is, it should be interpreted as meaning and concept consistent with the technical idea of the present invention.

1. Food composition for improving skin elasticity or moisture

One aspect of the present invention is a ginseng extract; and glue; as an active ingredient, providing a food composition for improving skin elasticity or moisture.

As used herein, the term 'extract' refers to a material extracted from a raw material by an arbitrary method, and is used in the meaning of including, without limitation, the extracted extract, the concentrate obtainable therefrom, the dried product and the powder of the concentrate.

In the present invention, 'ginseng extract' can be obtained by extracting ginseng or a dried product thereof, and the ginseng cultivated or commercially available can be used without limitation. The ginseng can be used in a sense that includes all of the various names in the ginseng industry law, and includes variously processed ones, for example, fresh ginseng, fine ginseng, black ginseng, wild ginseng, camphor ginseng, wild ginseng, white ginseng, Taegeuk ginseng, hojeonghwa ginseng, It may be at least one selected from the group consisting of enzyme-treated raw ginseng, fermented ginseng, red ginseng, and fermented red ginseng, but is not limited thereto. Fresh ginseng refers to raw ginseng that maintains its original shape, and fine ginseng refers to the fine root of ginseng. Red ginseng is made by steaming raw ginseng and drying it. During the drying process, a browning reaction takes place, resulting in a pale yellowish-brown to reddish-brown color. Black ginseng refers to ginseng changed to black by steaming and drying red ginseng several times. Wild ginseng refers to native ginseng, and Jangnoe ginseng refers to planted and grown wild ginseng. Wild ginseng is ginseng cultivated by artificially sowing and transplanting seeds or seedlings under mountainous forests.

When obtaining the extract from the ginseng, as the extraction method, all conventional known extraction methods such as solvent extraction, ultrasonic extraction, filtration, and reflux extraction may be used, and preferably by using a solvent extraction method or reflux extraction method. have. The extraction process may be repeated several times. The extract also includes a fraction obtained by further fractionating the extract.

When obtaining the extract from the ginseng, at least one selected from the group consisting of water, an organic solvent, a supercritical fluid, and a mixture thereof may be used as an extraction solvent. The organic solvent is an alcohol, preferably a C1-C4 lower alcohol, hexane (n-hexane), ether, glycerol, propylene glycol, butylene glycol, ethyl acetate, methyl acetate, dichloromethane, chloroform, ethyl acetate, benzene and It may be any one selected from the group consisting of these mixed solvents, preferably water. When a mixture of water and an organic solvent is used as the extraction solvent, it may be preferably a mixture of water and a C1-C4 lower alcohol, and more preferably a mixture of water and ethanol.

In addition, when preparing the ginseng extract, the extraction may be carried out at 50 ° C. to 100 ° C., preferably at 70 ° C. to 100 ° C., more preferably at 90 ° C. to 100 ° C. Not limited. The extraction may be carried out for 2 hours to 12 hours, preferably for 2 hours to 10 hours, and more preferably for 2 hours to 8 hours, but is not limited thereto. The extraction may be performed 1 to 8 times, preferably 1 to 6 times, and more preferably 1 to 4 times, but is not limited thereto.

In the present invention, glue is produced by heating leather or bones derived from animals such as cattle, horses, and donkeys as raw materials, heating them with water, removing fat, concentrating and drying, and preferably derived from donkeys used as medicines. Glue (Colla Corii Asini).

The glue of the present invention may be a conventional commercially available glue block, or an extract formed by adding a solvent to the hide or bone of a donkey by a conventional method and extracting it, then concentrating and drying it. Specific process conditions for preparing the extract may be in a conventional manner.

When obtaining the extract from the donkey hide or bone, at least one selected from the group consisting of water, an organic solvent, a supercritical fluid, and a mixture thereof may be used as an extraction solvent. The organic solvent is an alcohol, preferably a C1-C4 lower alcohol, hexane (n-hexane), ether, glycerol, propylene glycol, butylene glycol, ethyl acetate, methyl acetate, dichloromethane, chloroform, ethyl acetate, benzene and It may be any one selected from the group consisting of these mixed solvents, preferably water. When a mixture of water and an organic solvent is used as the extraction solvent, it may be preferably a mixture of water and a C1-C4 lower alcohol, and more preferably a mixture of water and ethanol.

In addition, the extraction temperature may be carried out at 70 °C to 120 °C, preferably at 80 °C to 120 °C, more preferably at 90 °C to 120 °C, but is not limited thereto. The extraction may be carried out for 2 hours to 12 hours, preferably for 2 hours to 8 hours, and more preferably for 2 hours to 4 hours, but is not limited thereto. The extraction may be performed 1 to 4 times, preferably 1 to 3 times, and more preferably 1 to 2 times, but is not limited thereto. Drying of the extract may be carried out at 0 ~ 25 ℃, or 0 ~ 15 ℃, it may be carried out for 8 ~ 15 hours, or 10 ~ 12 hours.

The food composition of the present invention contains 35 to 65 parts by weight of glue with respect to 50 parts by weight of the ginseng extract, 37 to 63 parts by weight of the glue with respect to 50 parts by weight of the ginseng extract, or 40 parts by weight of the glue with respect to 50 parts by weight of the ginseng extract to 60 parts by weight, or 42 to 58 parts by weight of the glue with respect to 50 parts by weight of the ginseng extract, or 45 to 55 parts by weight of the glue with respect to 50 parts by weight of the ginseng extract, or the glue with respect to 50 parts by weight of the ginseng extract may be included in an amount of 47 to 53 parts by weight. When the above numerical range is satisfied, the skin's elasticity or moisture improvement effect may be excellent as collagen synthesis ability of the skin is further improved. In particular, when 50 parts by weight of glue is included based on 50 parts by weight of ginseng extract, excellent skin elasticity Or it may exhibit a moisturizing improvement effect.

The food composition is a ginseng extract and glue of the present invention In addition, within the range that does not impair the effect of the present invention, it may further contain, preferably, other ingredients that can give a synergistic effect to the effect of the ginseng extract and the glue. For example, it may contain conventional adjuvants such as stabilizers, solubilizers, vitamins and the like, or carriers.

In addition, it may include ingredients commonly added during food production, for example, proteins, carbohydrates, fats, nutrients, seasonings and flavoring agents. Examples of the carbohydrate include monosaccharides such as glucose, fructose and the like; disaccharides such as maltose, sucrose, oligosaccharides and the like; and polysaccharides, for example, conventional sugars such as dextrin, cyclodextrin, and the like, and sugar alcohols such as xylitol, sorbitol, and erythritol. As the flavoring agent, a natural flavoring agent taumatin, a stevia extract, and a synthetic flavoring agent may be used. For example, when the food composition of the present invention is prepared as a drink, citric acid, high fructose, sugar, glucose, acetic acid, malic acid, fruit juice, natural extract, etc. may be additionally included in addition to the ginseng extract and glue of the present invention.

There is no particular limitation on the type of food using the food composition. Examples of foods to which the food composition containing the ginseng extract and glue of the present invention can be added include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream , various soups, beverages, teas, drinks, alcoholic beverages, and vitamin complexes, and includes all foods in a conventional sense.

The food can be manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, etc. for the purpose of improving skin elasticity or moisture.

For example, food in tablet form is granulated by a mixture obtained by mixing the food composition with excipients, binders, disintegrants and other additives in a conventional manner, followed by compression molding by adding a lubricant or the like, or by directly compressing the mixture. can be molded. In addition, the food in the form of tablets may contain a corrosive agent or the like, if necessary.

Hard capsules among foods in capsule form can be prepared by filling a mixture of the food composition with additives such as excipients in conventional hard capsules, and soft capsules are gelatin obtained by mixing the food composition with additives such as excipients. It can be prepared by filling in a capsule base such as The soft capsules may contain a plasticizer such as glycerin or sorbitol, a colorant, a preservative, and the like, if necessary.

Food in the form of a ring can be prepared by molding a mixture in which the food composition and excipients, binders, disintegrants, etc. are mixed by a known method, and if necessary, can be coated with sucrose or other skinning agent, or starch, It is also possible to coat the surface with a material such as talc.

Food in the form of granules may be prepared in a granular form by a conventionally known method by mixing a mixture of the food composition with an excipient, binder, disintegrant, etc., and may contain a flavoring agent, a flavoring agent, etc. as necessary.

2. Pharmaceutical composition for improving skin elasticity or moisture

One aspect of the present invention is a ginseng extract; And glue; provides a pharmaceutical composition for improving skin elasticity or moisture, comprising as an active ingredient.

The pharmaceutical composition of the present invention comprises 35 to 65 parts by weight of glue based on 50 parts by weight of the ginseng extract, 37 to 63 parts by weight of the glue with respect to 50 parts by weight of the ginseng extract, or 50 parts by weight of the ginseng extract. 40 to 60 parts by weight, or 42 to 58 parts by weight of glue with respect to 50 parts by weight of ginseng extract, 45 to 55 parts by weight of glue with respect to 50 parts by weight of ginseng extract, or 50 parts by weight of ginseng extract Glue may be included in an amount of 47 to 53 parts by weight. When the above numerical range is satisfied, the skin elasticity or moisture improvement effect may be excellent as the collagen synthesis ability of the skin is further improved. Or it may exhibit a moisturizing improvement effect.

In addition to the ginseng extract and the glue, the pharmaceutical composition of the present invention preferably adds other ingredients that can give a synergistic effect to the effect of the ginseng extract and the glue within a range that does not impair the effect of the present invention. may contain. For example, antioxidants, stabilizers, solubilizers, conventional adjuvants such as vitamins, or carriers may be included.

The route of administration of the pharmaceutical composition should be through the oral cavity.

The pharmaceutical composition of the present invention may be administered in a pharmaceutically effective amount.

In the present invention, "pharmaceutically effective amount" means an amount sufficient to treat a disease at a reasonable benefit/risk ratio applicable to medical treatment, and the effective dose level includes the subject type and severity, age, sex, type of disease, The activity of the drug, the sensitivity to the drug, the time of administration, the route of administration and the rate of excretion, the duration of treatment, factors including concurrent drugs, and other factors well known in the medical field can be determined according to factors. The composition of the present invention may be administered as an individual therapeutic agent or in combination with other therapeutic agents, and may be administered sequentially or simultaneously with conventional therapeutic agents. and may be administered single or multiple. Taking all of the above factors into consideration, it is important to administer an amount that can obtain the maximum effect with a minimum amount without side effects, and can be easily determined by a person skilled in the art.

The pharmaceutical composition of the present invention is not particularly limited as long as it is an individual for the purpose of improving skin elasticity or moisturizing, and any one is applicable. For example, the pharmaceutical composition of the present invention can be used not only for humans but also for non-human animals such as monkeys, dogs, cats, rabbits, guinea pigs, rats, mice, cattle, sheep, pigs, goats, etc., birds and fish. do.

The pharmaceutical composition may contain one or more active ingredients exhibiting the same or similar functions in addition to the ginseng extract and glue. The pharmaceutical composition may be formulated and used in oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, and the like according to a conventional method, respectively.

Solid preparations for oral administration include powders, granules, tablets, capsules, soft capsules, pills, and the like. Liquid formulations for oral administration include suspensions, solutions, emulsions, syrups, etc. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have.

The pharmaceutical composition may further contain adjuvants such as preservatives, stabilizers, wetting agents or emulsification accelerators, salts and/or buffers for regulating osmotic pressure, and other therapeutically useful substances, and mixing, granulation, which is a conventional method It can be formulated according to the method of formulation or coating.

The dosage of the pharmaceutical composition may vary according to various factors including the age, weight, general health, sex, administration time, administration route, excretion rate, drug formulation, and severity of a specific disease of the individual.

In addition, the pharmaceutical composition of the present invention can be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, and biological response modifiers. In addition, the pharmaceutical composition may be administered in a dosage within the range of 0.001 to 200 mg/kg based on an adult, but the dosage is not limited to the scope of the present invention.

Hereinafter, the present invention will be described in detail by way of Examples.

However, the following examples are only for illustrating the present invention, and the content of the present invention is not limited by the following examples.

<Preparation Example 1> Preparation of red ginseng concentrate

After adding 8 to 12 times of purified water to 20 kg of red ginseng, it was extracted 4 times at 90±10° C. for 8 hours, and then centrifuged at low temperature and concentrated under reduced pressure to obtain 14 kg of red ginseng concentrate.

<Production Example 2> Preparation of glue

8-12 times of purified water was added to 20 kg of donkey skin, extracted three times at 90±10° C. for 4 hours, and then centrifuged at low temperature, concentrated and dried under reduced pressure to obtain 8 kg of glue.

<Preparation Example 3> Preparation of a complex of red ginseng concentrate and glue

A mixture of red ginseng concentrate and glue was prepared by varying the ratio of the single extract obtained in Preparation Examples 1 and 2 prepared. Three types of mixtures were prepared by adjusting the red ginseng concentrate and the amount of glue to 100 µg/ml: 100 µg/ml, 100 µg/ml: 50 µg/ml, and 50 µg/ml: 100 µg/ml.

<Example 1> Confirmation of procollagen synthesis ability

<1-1> Experimental method

Skin fibroblasts (ATCC, USA) were aliquoted at 1×10 ⁵ in a 24-well plate, and 10% bovine serum was added to a DMEM:F12 mixed medium and cultured at 37° C., 5% CO ₂ incubator. After 24 hours, the red ginseng concentrate of Preparation Example 1 and the glue of Preparation Example 2 were treated alone at a concentration of 50 μg/ml or 100 μg/ml, respectively, and the complex of the red ginseng concentrate of Preparation Example 3 and the glue was treated, As a positive control group, L-ascorbic acid was treated at a concentration of 20 μg/ml. After 24 hours of sample treatment, only the supernatant was separated, and the increase or decrease of procollagen in the supernatant was observed using a procollagen type (I) ELISA kit (Takara, Japan) in the supernatant.

The increase (%) of procollagen type I synthesis compared to the untreated control group was calculated, but all values were prepared as the mean±standard deviation after repeated measurement twice, and the results are shown in FIG. 1 .

<1-2> Procollagen synthesis ability

From Figure 1, in the case of the red ginseng concentrate and the glue, the procollagen synthesizing ability is superior compared to the case of the glue alone treatment. By weight, it can be confirmed that the most excellent procollagen synthesis effect when used.

<Preparation Example 4> Preparation of food composition comprising red ginseng concentrate and glue

Honey (Honey Tea, Premium Acacia Honey) 120g, Plant Mixture Concentrate (KGC Yebon, Plant Mixture Concentrate 1120) 30g, Maltooligosaccharide (Ingredion Korea, MO-R1) 490g Heat (80~100℃) and mix with stirring. A first mixture was formed.

After adding 100 g of the glue of Preparation Example 2 to 100 g of purified water at room temperature and stirring to dissolve it, the present glue solution was added to the first mixture and stirred to form a second mixture.

100 g of the red ginseng concentrate of Preparation Example 1 and 60 g of purified water were added to the second mixture and mixed to prepare a viscous liquid composition.

<Example 2> Skin moisturizing effect improvement effect

<2-1> Experimental method

In order to verify the skin moisturizing effect after ingestion of the food composition of Preparation Example 4, 6 adult men and women in their 40s to 50s (12 in total) were allowed to ingest the food composition once daily for 8 weeks.

Before taking the product, the subject's forearm was washed with running water, and the moisture content of the skin was measured with a Corneometer CM825 under constant temperature and humidity conditions (20~24℃, 40~60% RH). After 4 weeks of ingestion and 8 weeks after ingestion, subjects were asked to ingest the product, and the moisture content of the skin was measured with a corneometer CM825 in the same manner. The measurement was repeated 5 times, and the average of the three measurements with the maximum and minimum values removed was shown, and statistical analysis was performed using the Wilcoxon signed rank test using IBM SPSS statistical tool (USA). The results are shown in FIG. 2 .

<2-2> Skin hydration

From Figure 2, it can be confirmed that the skin moisturizing power is improved by ingesting the food composition of the present invention. Specifically, it can be seen that the degree of skin hydration is significantly improved after ingesting the food composition of the present invention for 8 weeks.

<Example 3> Skin elasticity improvement effect

<3-1> Experimental method

In order to verify the skin elasticity improvement effect after ingestion of the food composition of Preparation Example 4, 6 adult men and women in their 40s to 50s (12 in total) were allowed to ingest the food composition once daily for 8 weeks.

Before taking the product, the subject's forearm was washed with running water, and skin elasticity was measured with a Cutometer MPA580 under constant temperature and humidity conditions (20~24℃, 40~60% RH). After 4 weeks of ingestion and 8 weeks after ingestion, subjects were asked to ingest the product, and skin elasticity was measured with a cutometer MPA580 in the same manner. Measurements were repeated three times to represent the average, and statistical analysis was performed using the Wilcoxon signed rank test using IBM SPSS statistical tool (USA). The results are shown in FIG. 3 .

<3-2> Skin elasticity

From FIG. 3, it can be confirmed that skin elasticity is improved by ingesting the food composition of the present invention. Specifically, it can be seen that skin elasticity is significantly improved after ingesting the food composition of the present invention for 8 weeks.

<Preparation Example 5> Preparation of beverage

<5-1> Manufacturing of health drinks

Mixture of the red ginseng concentrate and glue of the present invention with auxiliary materials such as high fructose (0.5%), oligosaccharide (2%), sugar (2%), salt (0.5%), and water (75%) 5 g was homogeneously mixed and instantaneously sterilized, and then packaged in small packaging containers such as glass bottles and plastic bottles.

<5-2> Preparation of vegetable juice

Vegetable juice was prepared by adding 5 g of a mixture of red ginseng concentrate and glue of the present invention (weight ratio 1:1) to 1,000 ml of tomato or carrot juice.

<5-3> Preparation of fruit juice

Fruit juice was prepared by adding 1 g of a mixture of red ginseng concentrate of the present invention and glue (weight ratio 1:1) to 1,000 ml of apple or grape juice.

Claims (7)

ginseng extract; And glue; A food composition for improving skin elasticity or moisture, comprising as an active ingredient. The method according to claim 1,
A food composition comprising 40 to 60 parts by weight of a glue based on 50 parts by weight of the ginseng extract. The method according to claim 1,
A food composition comprising 45 to 55 parts by weight of a glue based on 50 parts by weight of the ginseng extract. The method according to claim 1,
A food composition comprising 47 to 53 parts by weight of a glue based on 50 parts by weight of the ginseng extract. The method according to claim 1,
The ginseng extract is a food composition obtained by adding water to ginseng and extracting it at 50 to 100° C. for 2 to 12 hours. The method according to claim 1,
The glue is a donkey-derived food composition. The method according to claim 1,
A food composition selected from the group consisting of beverages, teas, drinks, alcoholic beverages and vitamin complexes.

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