KR20220095978A - Cosmetic composition for skin moisturing comprising hydrogenated phosphatidylcholine and calcium compound and preparation method thereof - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin moisturizing with a specific objective of alleviating extremely dry skin. More specifically, the present invention relates to a composition comprising hydrogenated phosphatidylcholine, which is a constitutive component of human cell membranes. The composition according to the present invention forms a moisturizing film on extremely dry skin by rapidly spreading, creates a moist environment by moisturizing the extremely dry skin by improving the imbalance of cell membrane composition on the skin, thereby being able to maintain a constant humidity contributing to skin health.

Description

Moisturizing cosmetic composition comprising hydrogenated phosphatidylcholine and calcium compound, and manufacturing method thereof

The present invention relates to a moisturizing cosmetic composition for the purpose of improving extremely dry skin and a method for preparing the same. It is an invention of improving to form a moisturizing film by diffusion, and to improve the imbalance of cell film composition on the skin to create a moist environment by moisturizing for extremely dry skin and to maintain a certain humidity that contributes to skin health.

Atopic dermatitis is a chronic, recurrent inflammatory skin disease that mainly begins in infancy or childhood, and is accompanied by pruritus (itch), dry skin, and characteristic eczema. In infancy, it begins as eczema on the face and on the outstretched side of the limbs, but as you grow older, it characteristically appears in the form of eczema on the bent part of the arm and the bent part of the knee, and in many cases, it tends to improve naturally with growth . In the case of adults, lichenification, which thickens the skin at the fold, appears, and eczema occurs on the face more often than in childhood. Atopic dermatitis is increasing worldwide, and there is a report that the prevalence is 20% of the population.

The main symptoms of atopic dermatitis are severe itching (itchiness), dry skin, and skin lesions. Dry skin causes and worsens itching. Itching is intermittent during the day and usually gets worse in the early evening or midnight. When scratching because it is itchy, eczematous skin lesions (pathological changes) occur, and as these lesions progress, the vicious cycle repeats in which more severe itching is induced.

The distribution and response patterns of skin lesions are somewhat different depending on the age of the patient. In the case of infants, the lesions are mainly scabs and acute eczema. They are mainly found on the face and head, the body is rough and dry, and it often occurs on the outside of the limbs. In children between the ages of 2 and 10, it occurs in the folds of the arms and legs and the folds of the neck rather than the face and often appears in the form of dry eczema. On the other hand, in Asians, severe nipple eczema that does not heal well after teenage years may appear.

Atopic dermatitis often improves or disappears with age, but even after improvement, itching or inflammatory reaction tends to occur easily due to certain substances or stimuli, and hand eczema often appears in adulthood. If atopic dermatitis remains until adulthood, while the skin symptoms on the body improve, erythema, redness, and eczema tend to appear on the face, and lichenified skin that looks thick due to long scraping of the folds appears. Even in adulthood, chronic eczema does not only appear, but acute lesions in which oozes and crusts sit on chronic eczema occur repeatedly at intervals of some time.

The cause of atopic dermatitis is still unknown. Because clinical symptoms also appear in various ways such as dry skin and eczema, the cause cannot be explained by only one, but environmental factors, genetic predisposition, immunological reactions, and abnormal skin barrier are considered to be the main causes. Environmental factors include environmental pollution such as soot due to industrialization, increase in the use of food additives, increase in the use of carpets, beds, and sofas due to Western-style housing, and substances (allergens) ) increase, etc.

In addition, as more and more pets are kept indoors, exposure to causative substances is also a cause. On the other hand, the fact that atopic dermatitis is genetically affected can be seen from the fact that many patients with atopic dermatitis have a family history.

Republic of Korea Patent Registration No. 10-1508714

An object of the present invention is to provide a moisturizing cosmetic composition for improving extremely dry skin, which has excellent moisturizing effect and can impart a moisturizing effect to extremely dry skin.

In one embodiment of the present invention, the present invention provides a moisturizing cosmetic composition for improving extremely dry skin comprising hydrogenated phosphatidylcholine, an organic acid containing two or more carboxyl groups, and a calcium compound as active ingredients.

The hydrogenated phosphatidylcholine may be present in a concentration of 0.01 g/ml to 120 g/ml based on the total weight of the cosmetic composition, but is not limited thereto.

The organic acid containing two or more carboxyl groups is decanedioic acid, dodecanedioic acid, cyclopropanedicarboxylic acid, cyclohexanedicarboxylic acid, cyclobutanedicarboxylic acid, naphthalene-1,4-dicarboxylic acid, naphthalene -2,3-dicarboxylic acid, naphthalene-2,6-dicarboxylic acid, suberic acid, oxalic acid, malonic acid, succinic acid, phthalic acid, terephthalic acid, isophthalic acid, tetrahydrophthalic acid, hexahydrophthalic acid, pimelic acid, It may be one or more selected from the group consisting of sebacic acid, azelaic acid, glutaric acid, adipic acid, fumaric acid, maleic acid and itaconic acid, but is not limited thereto.

The composition may have a pH of 4.75 to 6.95.

The composition may further include glycerin.

The calcium compound may be at least one selected from the group consisting of calcium chloride, calcium carbonate, calcium sulfate, calcium nitrate, calcium phosphate, calcium acetate and calcium lactate, but is not limited thereto.

The composition may further include a thickener, a preservative, a neutralizer, an anti-inflammatory agent, and purified water, but is not limited thereto.

In another embodiment of the present invention, mixing the hydrogenated phosphatidylcholine and a calcium compound; Mixing the mixture and a thickener, preservative, neutralizing agent, anti-inflammatory agent and purified water; and adjusting the pH to 4.75 to 6.95 with an organic acid containing two or more carboxyl groups. to provide.

In the step of mixing the hydrogenated phosphatidylcholine and the calcium compound, glycerin may be further mixed.

The present invention relates to a moisturizing cosmetic composition for improving extremely dry skin comprising, as active ingredients, hydrogenated phosphatidylcholine, an organic acid containing two or more carboxyl groups, and a calcium compound. It can be used as a cosmetic composition for the prevention and improvement of atopy.

Hereinafter, the present invention will be described in more detail through Examples and Experimental Examples. However, these examples are only for helping the understanding of the present invention, and the scope of the present invention is not limited to these examples in any sense.

Throughout the specification of the present invention, when a part "includes" a certain component, it means that other components may be further included, rather than excluding other components, unless otherwise stated.

Throughout the specification of the present invention, when a step is positioned “on” or “before” another step, this means not only a case in which a step is in a direct time-series relationship with another step, but also a step of mixing after each step and Likewise, the order of two steps may include the same rights as in the case of an indirect time-series relationship in which the time-series order may change.

The terms "about", "substantially", etc. to the extent used throughout the specification of the present invention are used in or close to the numerical value when the manufacturing and material tolerances inherent in the stated meaning are presented, and the present invention It is used to prevent an unconscionable infringer from using the disclosure in which exact or absolute figures are mentioned to help the understanding of the As used throughout this specification, the term “step of” or “step of” does not mean “step for.”

In one embodiment of the present invention, the present invention provides a moisturizing cosmetic composition for improving extremely dry skin comprising hydrogenated phosphatidylcholine (HPC), an organic acid containing two or more carboxyl groups, and a calcium compound as active ingredients.

Phosphatidylcholine is extracted from soybeans. Here, phosphatidylcholine (PPC) is extracted from soybeans composed of phospholipids of cell membrane components. In addition, the phosphatidylcholine targets the cellulite layer, separates the binding of fat cells in the cellulite layer, breaks the cell wall and dissolves the fat, and then absorbs and discharges the fat through blood and lymphatic vessels, or directly excreted through sweat It is a natural enzyme that breaks down fat. In addition, the phosphatidylcholine may be used in a liquid form extracted from soybeans, or may be used by processing the extracted phosphatidylcholine in a powder form.

In the present invention, "hydrogenated phosphatidylcholine (HPC)" refers to phosphatidylcholine in which all unsaturated fatty acids of the phosphatidylcholine are modified with saturated fatty acids.

The hydrogenated phosphatidylcholine may be present in a concentration of 0.01 g/ml to 120 g/ml based on the total weight of the cosmetic composition, but is not limited thereto. If the hydrogenated phosphatidylcholine is less than the concentration, the effect is insignificant, and if it exceeds the concentration, there may be a problem in formulation stability.

The organic acid containing two or more carboxyl groups is decanedioic acid, dodecanedioic acid, cyclopropanedicarboxylic acid, cyclohexanedicarboxylic acid, cyclobutanedicarboxylic acid, naphthalene-1,4-dicarboxylic acid, naphthalene -2,3-dicarboxylic acid, naphthalene-2,6-dicarboxylic acid, suberic acid, oxalic acid, malonic acid, succinic acid, phthalic acid, terephthalic acid, isophthalic acid, tetrahydrophthalic acid, hexahydrophthalic acid, pimelic acid, It may be one or more selected from the group consisting of sebacic acid, azelaic acid, glutaric acid, adipic acid, fumaric acid, maleic acid and itaconic acid, but is not limited thereto. In the moisturizing cosmetic composition for improving extremely dry skin of the present invention, the skin moisturizing effect is further improved when the pH is adjusted with the organic acid containing two or more carboxyl groups as described above compared to the case where the pH is adjusted with the organic acid containing one carboxyl group confirmed that.

The composition may have a pH of 4.75 to 6.95, preferably a pH of 5.5 to 6.0, and the present inventors have confirmed that the highest skin moisturizing effect is exhibited when the pH is 5.85.

The composition may further include glycerin. The glycerin may be replaced with a commonly used moisturizer component, for example, butylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, diglycerin, propanediol, 1,2 -Hexanediol, sodium hyaluronate, urea and trehalose can be used.

The calcium compound may be at least one selected from the group consisting of calcium chloride, calcium carbonate, calcium sulfate, calcium nitrate, calcium phosphate, calcium acetate and calcium lactate, but is not limited thereto. The present inventors confirmed that the calcium compound further enhances the skin moisturizing effect together with hydrogenated phosphatidylcholine.

The composition may further include a thickener, a preservative, a neutralizer, an anti-inflammatory agent, and purified water, but is not limited thereto.

A conventional thickener may be used as the thickener. For example, carbomer, acrylate, ammonium acryloyldimethyltaurate/vpicopolymer, acrylate/C10-30 alkyl acrylate crosspolymer, xanthan gum, and cellulose gum can be used.

A conventional preservative may be used. For example, benzoic acid, paraoxybenzoic acid ester, a mixture of methylchloroisothiazolinone, phenoxyethanol, methylparaben, ethylparaben or propylparaben may be used.

The neutralizing agent may be included in the same amount as the thickener. The type of neutralizing agent is not particularly limited, and for example, triethanolamine, tromethamine, arginine, and the like may be used.

Anti-inflammatory agents are widely used in cosmetics for the purpose of soothing the skin. Non-steroidal benzidamine, indomethacin, ibuprofen, etc. are used as substances used as anti-inflammatory agents, and steroidal dexamethasone and hydrocortisone may be used.

Specifically, the moisturizing cosmetic composition for improving extremely dry skin contains 20 to 50% by weight of a mixture of hydrogenated phosphatidylcholine and a calcium compound, 0.1 to 1% by weight of a thickener, 1 to 3% by weight of a preservative, and 0.1% by weight of a neutralizing agent based on the total weight of the cosmetic composition ~ 1% by weight, anti-inflammatory agent 1-3% by weight, may include 40 to 70% by weight of purified water.

The mixture of the hydrogenated phosphatidylcholine and the calcium compound may be a mixture of the hydrogenated phosphatidylcholine, the calcium compound, and glycerin.

In another embodiment of the present invention, 1) mixing the hydrogenated phosphatidylcholine and a calcium compound; 2) mixing the mixture and a thickener, preservative, neutralizing agent, anti-inflammatory agent and purified water; and 3) adjusting the pH to 4.75 to 6.95 with an organic acid containing two or more carboxyl groups. A method for preparing a composition is provided.

In step 1), a moisturizing agent, for example, glycerin may be further added.

The mixture of the hydrogenated phosphatidylcholine and the calcium compound is 20 to 50% by weight, 0.1 to 1% by weight of a thickener, 1 to 3% by weight of a preservative, 0.1 to 1% by weight of a neutralizing agent, 1 to 3% by weight of an anti-inflammatory agent, based on the total weight of the cosmetic composition %, it may contain 40 to 70% by weight of purified water.

The mixture of the hydrogenated phosphatidylcholine and the calcium compound may be a mixture of the hydrogenated phosphatidylcholine, the calcium compound, and glycerin.

Since the specific characteristics of the manufacturing method are the same as the above-mentioned moisturizing cosmetic composition for improving extremely dry skin, a detailed description will be omitted to avoid overlapping description.

Hereinafter, the present invention will be described in more detail through examples according to an embodiment of the present invention, but these do not limit the scope of the present invention.

<Example 1> Preparation of moisturizing cosmetic composition comprising hydrated phosphatidylcholine

1. Preparation of phosphatidylcholine

1.5 kg of soybean or egg yolk lecithin was dissolved in a solvent mixed with hexane and isopropyl alcohol in a 1:1 ratio to 20% by weight, and then quantified in a column (ID 15 x L 96 cm) filled with silica gel stabilized with the same solvent It was injected at a rate of 400 ml/min using a pump. After that, hexane/isopropyl alcohol solvent in which 5% water and 10% water were mixed was flowed 6 times and 9 times, respectively. The fractions were identified, and the PC fraction was separately recovered. The recovered PC fraction was filtered through a 0.45 μm filter, dried under vacuum, and then resuspended in distilled water and freeze-dried. In this way, about 20% of soybean PC and about 67% of egg yolk PC were obtained.

2. Preparation of hydrated phosphatidylcholine

After dissolving the obtained phosphatidylcholine in about 4 times the methanol/isopropyl alcohol/ethanol mixed solvent, 4% of palladium catalyst was added and the mixture was heated to 50°C. After that, a hydrogen pressure of 15 atm was applied to reduce the double bonds present in high-purity PC and convert it to a saturated fatty acid. As a result of confirming the PC prepared in this way by gas chromatography, it was confirmed that all of the PCs were converted to the corresponding saturated fatty acids.

3. Preparation of moisturizing cosmetic composition

200 g of the hydrated phosphatidylcholine and 5 g of calcium chloride were completely dissolved in 100 ml of water, and then mixed with glycerin in a weight ratio of 1:1 to prepare a moisturizing cosmetic composition as shown in [Table 1]. Thereafter, malonic acid was added to the composition, and the pH was adjusted to 4.75.

mixture thickener
(Xanthan Gum) antiseptic
(benzoic acid) corrector
(Arginine) anti-inflammatory
(Benzidamine) Purified water composition ratio
(weight%) 30 0.5 1.5 0.5 1.5 66

<Examples 2 and 3>

The pH was adjusted to 5.85 (Example 2) and 6.95 (Example 3) to prepare a moisturizing cosmetic composition in the same manner as in Example.

<Comparative Example 1>

Without adding calcium chloride, a moisturizing cosmetic composition was prepared in the same manner as in Example.

<Comparative Example 2>

In [Table 1], a moisturizing cosmetic composition was prepared in the same manner as in Examples by replacing the mixture with glycerin.

<Comparative Example 3>

By adding acetic acid instead of malonic acid to adjust the pH to 5.85, a moisturizing cosmetic composition was prepared in the same manner as in Example.

<Experimental example>

1. Skin moisturizing effect

The skin moisturizing power improvement effect of the present invention was evaluated through an actual use test. After the compositions of Examples and Comparative Examples were applied to the upper arms of each of 5 women aged 30 to 40 years, the amount of transdermal water loss was measured using TEWAMETER TM210 (C+K eletronic GmhH. Germany). That is, the skin barrier recovery rate (%) was confirmed by measuring the TEWL (Transepidermal Water Loss) value and the TEWL value change with time. The experimental results are shown in [Table 2] below.

Skin barrier recovery rate (%) Early 4 weeks Example 1 24.17 92.69 Example 2 24.12 94.75 Example 3 23.39 93.23 Comparative Example 1 23.54 80.64 Comparative Example 2 22.12 63.95 Comparative Example 3 23.47 85.72

Referring to [Table 2], Example 2 with a pH of 5.85 showed the highest skin barrier recovery rate. Referring to Comparative Example 1, even when only hydrated phosphatidylcholine was added, when compared with Comparative Example 2 in which only glycerin was added, it was confirmed that the skin barrier recovery rate was excellent, but when compared with Examples 1 to 3 in which calcium chloride was added It was confirmed that the skin barrier recovery rate decreased.

Therefore, it was confirmed that the use of hydrated phosphatidylcholine together with calcium chloride improves the skin moisturizing effect.

In addition, referring to Comparative Example 3, when the pH was adjusted with acetic acid containing one carboxyl group, it was confirmed that the skin moisturizing effect was lower than when the pH was adjusted with malonic acid having two carboxyl groups.

Claims (10)

A moisturizing cosmetic composition for improving extremely dry skin comprising hydrogenated phosphatidylcholine, an organic acid containing two or more carboxyl groups, and a calcium compound as active ingredients.
According to claim 1,
The hydrogenated phosphatidylcholine is a moisturizing cosmetic composition for improving extremely dry skin, characterized in that it is present in a concentration of 0.01 g/ml to 120 g/ml.
According to claim 1,
The organic acid containing two or more carboxyl groups is decanedioic acid, dodecanedioic acid, cyclopropanedicarboxylic acid, cyclohexanedicarboxylic acid, cyclobutanedicarboxylic acid, naphthalene-1,4-dicarboxylic acid, naphthalene -2,3-dicarboxylic acid, naphthalene-2,6-dicarboxylic acid, suberic acid, oxalic acid, malonic acid, succinic acid, phthalic acid, terephthalic acid, isophthalic acid, tetrahydrophthalic acid, hexahydrophthalic acid, pimelic acid, A moisturizing cosmetic composition for improving extremely dry skin at least one selected from the group consisting of sebacic acid, azelaic acid, glutaric acid, adipic acid, fumaric acid, maleic acid and itaconic acid.
According to claim 1,
The composition is a moisturizing cosmetic composition for improving extremely dry skin having a pH of 4.75 to 6.95.
The method of claim 1,
The composition is a moisturizing cosmetic composition for improving extremely dry skin further comprising glycerin.
According to claim 1,
The calcium compound is at least one selected from the group consisting of calcium chloride, calcium carbonate, calcium sulfate, calcium nitrate, calcium phosphate, calcium acetate and calcium lactate, moisturizing cosmetic composition for improving extremely dry skin.
The method of claim 1,
The composition is a moisturizing cosmetic composition for improving extremely dry skin further comprising a thickener, a preservative, a neutralizer, an anti-inflammatory agent, and purified water.
mixing hydrogenated phosphatidylcholine and a calcium compound;
mixing the mixture and a thickener, a preservative, a neutralizing agent, an anti-inflammatory agent and purified water; and
A method for preparing a moisturizing cosmetic composition for improving extremely dry skin, comprising adjusting the pH to 4.75 to 6.95 with an organic acid containing two or more carboxyl groups.
9. The method of claim 8,
The calcium compound is at least one selected from the group consisting of calcium chloride, calcium carbonate, calcium sulfate, calcium nitrate, calcium phosphate, calcium acetate and calcium lactate.
9. The method of claim 8,
The organic acid containing two or more carboxyl groups is decanedioic acid, dodecanedioic acid, cyclopropanedicarboxylic acid, cyclohexanedicarboxylic acid, cyclobutanedicarboxylic acid, naphthalene-1,4-dicarboxylic acid, naphthalene -2,3-dicarboxylic acid, naphthalene-2,6-dicarboxylic acid, suberic acid, oxalic acid, malonic acid, succinic acid, phthalic acid, terephthalic acid, isophthalic acid, tetrahydrophthalic acid, hexahydrophthalic acid, pimelic acid, A method for preparing a moisturizing cosmetic composition for improving extremely dry skin at least one selected from the group consisting of sebacic acid, azelaic acid, glutaric acid, adipic acid, fumaric acid, maleic acid and itaconic acid.