KR20220069582A - Manufacture of beauty forming filler composition containing hyalunonic acid - Google Patents

Manufacture of beauty forming filler composition containing hyalunonic acid Download PDF

Info

Publication number
KR20220069582A
KR20220069582A KR1020200156844A KR20200156844A KR20220069582A KR 20220069582 A KR20220069582 A KR 20220069582A KR 1020200156844 A KR1020200156844 A KR 1020200156844A KR 20200156844 A KR20200156844 A KR 20200156844A KR 20220069582 A KR20220069582 A KR 20220069582A
Authority
KR
South Korea
Prior art keywords
filler composition
hyalunonic
composition containing
manufacture
acid
Prior art date
Application number
KR1020200156844A
Other languages
Korean (ko)
Inventor
김강훈
Original Assignee
주식회사 메이브리즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 메이브리즈 filed Critical 주식회사 메이브리즈
Priority to KR1020200156844A priority Critical patent/KR20220069582A/en
Publication of KR20220069582A publication Critical patent/KR20220069582A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention provides a hyaluronic acid-based hydrogel dermal filler composition which uses an injection method that is particularly advantageous for fine wrinkles on the face and the volume and correction of the entire body, and is long-lasting. The present invention relates to a method for manufacturing an injectable composition for cosmetic filler containing a fine biodegradable polymer having high cohesion and adhesion to skin tissue due to high HA concentration.

Description

히알루론산을 함유한 미용성형 필러 조성물 제조기술{Manufacture of beauty forming filler composition containing hyalunonic acid}Technology for manufacturing a cosmetic filler composition containing hyaluronic acid {Manufacture of beauty forming filler composition containing hyalunonic acid}

본 특허의 기술은 히알루론산(hyaluronic acid)과 하이드록시 아파타이트(hydroxy apatite) 의 가장 적절한 조합에 기초한 피부 및 피하(subdermal)에 투여하는 미용 필러(implantable fillers)에 관한 것이며 The technology of this patent relates to implantable fillers for dermal and subdermal administration based on the most suitable combination of hyaluronic acid and hydroxy apatite.

성형과 미용 필러용 주사제 조성물 제조와 장치에 관한 기술이다It is a technology related to the manufacturing and device of injection composition for cosmetic and cosmetic fillers

얼굴을 포함한 축쳐진 몸이 볼륨은 노화가 진행되는 피부, 연조직 및 두개안면골에서의 누적 효과로 인해 피부 표면 조직의 주름, 토포그래피 (topography) 및 안면 볼륨의 상실을 초래하는 우리 전생애 동안 일어나는 자연스러운 현상이다.Shaggy body volume, including the face, is a natural occurrence that occurs throughout our lifetimes resulting in wrinkles, topography and loss of facial volume in the skin surface tissue due to the cumulative effects of aging skin, soft tissue and craniofacial bone. It is a phenomenon.

이러한 노화의 결과는 중력, 진행형 골흡수, 조직 탄성 감소 및 피하지방 재분포 및 충만(fullness) 손실을 포함한다. 호르몬 불균형, 일광 노출, 정신적 스트레스, 식단, 작업 습관, 질병, 약물 남용 및 흡연이 또한 안면 매력에 영향을 가지고 올 수도 있다 The consequences of such aging include gravity, progressive bone resorption, decreased tissue elasticity, and redistribution of subcutaneous fat and loss of fullness. Hormonal imbalances, sun exposure, mental stress, diet, work habits, illness, substance abuse and smoking may also have an effect on facial attractiveness

인체에 무해 생분해성 고분자 재료를 조직에 투여 가능한 분산 매질에 혼합하여 사용하고 있는데, 이와 같이 제조된 성형필러용 주사제 조성물은 프리필드 주사기(Prefilled syringes)를 통해 치료 부위에 투여되어 조직세포의 치료 및 재생 등 자연스러운 모양을 촉진하는데 도움을 준다A biodegradable polymer material harmless to the human body is mixed with a dispersion medium that can be administered to tissues, and the injection composition for molded fillers prepared in this way is administered to the treatment site through prefilled syringes to treat and treat tissue cells. Helps promote natural appearance, such as regeneration

예를 들어 주름, 푹 꺼짐과, 수분 손실 및 노화의 외관에 따른 다른 원치 않는 형태와 같은 다양한 피부의 고민을 가지고 온다It brings with it a variety of skin concerns, for example wrinkles, sunken spots, moisture loss and other unwanted shapes that come with the appearance of aging.

본 발명의 목적은 성형필러용 주사제 조성물 제조 공정 상의 독성물질의 첨가로 인한 환경적, 인체 유해적 문제를 배제시키고,불순물을 제로에 가까운 안전성과 공정의 단순화를 통해 전체 제조 효율을 높임과 동시에 조성물의 물성적 품질을 개선할 수 있는 기술을 제공하는데 있다. An object of the present invention is to eliminate environmental and human harmful problems caused by the addition of toxic substances in the manufacturing process of injection composition for molding fillers, and increase overall manufacturing efficiency through safety close to zero impurities and simplification of the process, and at the same time It is to provide technology that can improve the physical properties of the product.

하이알루로난으로도 알려진 하이알루론산(hyaluronic acid: HA)은 관절, 상피, 및 신경 조직에서 인간 신체 전체적으로 넓게 분포되어 있다 하이알루론산은, 수분을 보충하고, 세포외 기질의 조직화를 도우며, 필러 물질로서 작용하고; 조직 손상 메커니즘에 참여하는 것과 같은 다양한 작용을 갖는 경우, 상이한 층의 피부 내에서 흔하다. 그러나, 연령에 따라, 피부 내 존재하는 하이알루론 산, 콜라겐, 엘라스틴 및 다른 기질 중합체의 양은 감소되어 푹꺼짐이나 여러 외관상 문제 때문에 이에 대한 해결방안을 위해 연구하고 있다Hyaluronic acid (HA), also known as hyaluronan, is widely distributed throughout the human body in joints, epithelium, and nervous tissue. Hyaluronic acid replenishes moisture, aids in the organization of the extracellular matrix, and acts as a filler material. do; It is common in different layers of skin if it has a variety of actions, such as participating in tissue damage mechanisms. However, with age, the amount of hyaluronic acid, collagen, elastin, and other matrix polymers present in the skin decreases, and studies are being conducted to solve these problems due to puffiness and various cosmetic problems.

주사용 진피 필러는 노화된 피부를 치료하는데 성공적으로 사용되고 있다. 신체의 꺼져있는 부위를 채우고 입체적인 육곽을 형성함으로써 피부의 탄력을 증가시키고 오랜기간 볼륨을 유지 할 수 있도록 하는데 도움을 준다.Injectable dermal fillers have been successfully used to treat aging skin. It helps to increase the elasticity of the skin and maintain its volume for a long time by filling in the dark parts of the body and forming a three-dimensional body.

본 발명의 현재 기재된 필러 겔 중 다수는 현재 상업적으로 입수가능한 겔 보다 생체내에서 유의하게 더 오래 지속되는 것으로 발견되었다. Many of the currently described filler gels of the present invention have been found to last significantly longer in vivo than currently commercially available gels.

본 발명의 일부 양태에서, 피부의 외관을 향상시키는데 유용한 광학적으로 투명한 진피 필러가 제공되는데, 이는 볼륨과 풍만함을 더하며, "틴들링" 없이 일정한 잔주름 주름살의 외관을 감소시키는데 효과적이다.In some aspects of the present invention, optically clear dermal fillers useful for enhancing the appearance of the skin are provided, which add volume and fullness, and are effective in reducing the appearance of constant fine lines and wrinkles without "tyndling".

본 조성물은 다수의 통상적인 광학적으로 투명한 진피 필러와 관련된 부정적인 푸른 변색을 야기하는일 없이 피부 내 잔주름에, 심지어 얇은 피부 영역에서도, 오히려 깊지 않게, 도입될 수 있다.The composition can be introduced into fine lines within the skin, even in thin skin areas, rather not deeply, without causing the negative blue discoloration associated with many conventional optically clear dermal fillers.

더 구체적으로는, 일반적으로 생체에 적합한 하이알루론산 성분 및 하이알루론산 성분과 조합된 첨가제를 포함하는, 장시간 지속되는 치료적 진피 필러 조성물이 "주사용"은 미세한 바늘로 주사 장치를 사용하여 하이드로겔 입자를 완벽한 주입감으로 인공적이지 않게 수행된다는 점이다.More specifically, a long-acting therapeutic dermal filler composition, generally comprising a biocompatible hyaluronic acid component and an additive in combination with a hyaluronic acid component, is "injectable" by using an injection device with a fine needle to completely deliver hydrogel particles. The point is that it is performed not artificially with a feeling of injection.

50cc의 대용량으로 기타 제품에 비해 월등히 높은 24mg/cc의 히알루논산 농도로 불순물 제로에 가까운 안전성을 가지고 가종조,엉덩이,골반,허벅지,팔꿈치,무릎, 종아리,등 남성과 여성의 생식기 등 바디 전체에 사용 가능한 필러이다 With a large capacity of 50cc, it has a hyaluronic acid concentration of 24mg/cc, which is much higher than other products, and has a safety close to zero impurities. filter that can be used

Claims (1)

환자의 얇은 피부에서 잔주름의 외관을 감소시키는 방법으로서, 상기 방법은, 약 1㎜ 이하의 깊이에서 비타민 C 또는 비타민 C 유도체를 포함하는 실질적으로 광학적으로 투명한 하이알루론 산계 진피 필러 조성물을 상기 환자에게 투여하는 단계를 포함하는, 잔주름의 외관 감소방법과 볼륨을 상승시키는 방법이다.A method of reducing the appearance of fine lines in thin skin of a patient, the method comprising administering to the patient a substantially optically transparent hyaluronic acid-based dermal filler composition comprising vitamin C or a vitamin C derivative at a depth of about 1 mm or less It is a method for reducing the appearance of fine lines and increasing the volume, including the steps.
KR1020200156844A 2020-11-20 2020-11-20 Manufacture of beauty forming filler composition containing hyalunonic acid KR20220069582A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020200156844A KR20220069582A (en) 2020-11-20 2020-11-20 Manufacture of beauty forming filler composition containing hyalunonic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020200156844A KR20220069582A (en) 2020-11-20 2020-11-20 Manufacture of beauty forming filler composition containing hyalunonic acid

Publications (1)

Publication Number Publication Date
KR20220069582A true KR20220069582A (en) 2022-05-27

Family

ID=81792147

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020200156844A KR20220069582A (en) 2020-11-20 2020-11-20 Manufacture of beauty forming filler composition containing hyalunonic acid

Country Status (1)

Country Link
KR (1) KR20220069582A (en)

Similar Documents

Publication Publication Date Title
Andre Hyaluronic acid and its use as a “rejuvenation” agent in cosmetic dermatology
US10493006B2 (en) Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use
Keen Hyaluronic acid in dermatology
Bergeret-Galley et al. The value of a new filler material in corrective and cosmetic surgery: DermaLive and DermaDeep
US7790194B2 (en) Polyacrylamide hydrogel as a soft tissue filler endoprosthesis
KR101236363B1 (en) Particles for soft tissue augmentation
JP5735965B2 (en) Injectable composition combining filler and fibroblast growth medium
AU2020207813B2 (en) Implants for sculpting, augmenting or correcting facial features such as the chin
CN111132705A (en) Sterile injection composition containing cross-linked hyaluronic acid and articaine
EP1418188B1 (en) Polyacrylamide hydrogel and its use as an endoprosthesis
RU2289417C1 (en) Method for biological skin rejuvenation
CN110279888A (en) A kind of injection Ago-Gel agent and preparation method thereof
KR20210044168A (en) Filler compositions
JP2004517655A (en) How to repair fat bodies
KR20220069582A (en) Manufacture of beauty forming filler composition containing hyalunonic acid
EP2254584A1 (en) Biocompatible injectable products with zinc and/or zinc-form saccharide-salt release, and uses thereof
KR102348467B1 (en) A method for manufacturing a filler containing dna fraction and the filler prepared therefrom
KR102324076B1 (en) Composition for improving skin wrinkles and elasticity through induction of elastin and collagen
de Sanctis Pecora The gold protocol: A combined treatment approach for neck rejuvenation with calcium hydroxyapatite, botulinum toxin, and hyaluronic acid in the same session
Sadick Filler Biologic Properties and Techniques
Radu et al. Cosmetic Fillers
Pratama et al. The Current Art Combination of Platelet-Rich Plasma and Poly-D, L-Lactic Acid for Improvement of Deep Nasolabial Folds: A Case Report
Devi et al. Significance of hyaluronic acid in the biomedical field: A review
WO2020095079A1 (en) Injectable composition containing hyaluronic acid, intended for the body
WO2021259471A1 (en) DERMAL FILLER WITH HIF-1α ACTIVITY MODULATORS