KR20220060227A - formulation stabilizer for gel network structure formulation and composition containing same - Google Patents

Abstract

The present invention relates to a cosmetic composition. In the present disclosure, a high content of positive ionic polymer can be included. As above, there is an effect of increasing the sustainability of active ingredients by sufficiently containing positive ionic polymer.

Description

Formulation stabilizer for gel network structure formulation and composition containing same

Disclosed herein are formulation stabilizers that stabilize the composition using a gel network structure, and a composition comprising the same.

In the case of emulsion type emulsions used in cosmetics, various additional functions such as UV protection and skin improvement functions are considered important in addition to basic skin protection functions. However, it is not technically easy to sustain these cosmetic properties for a long time, so it is difficult to develop a satisfactory product. In order to increase the durability of the effective ingredient, Japanese Patent Laid-Open No. 2004-182731 discloses a method of applying a physical method such as heat, electromagnetic wave, electric field, sound wave, or plasma, but it is practically unreasonable to apply high energy during the makeup process. there is. Accordingly, it may be considered to add a cationic polymer, but due to the polarity of the cationic polymer, there is a problem that it cannot be added in a high content to achieve desired physical properties. Accordingly, there is a need to develop a composition capable of increasing the durability of an effective ingredient by sufficiently containing a cationic polymer.

Japanese Patent Laid-Open No. 2004-182731

The present disclosure has been devised to solve the above problems, and an object of the present disclosure is to provide a composition capable of increasing the durability of an effective ingredient by sufficiently containing a cationic polymer.

In order to achieve the object of the present disclosure described above, one aspect of the present disclosure includes a pH adjusting agent as an active ingredient, and uses a gel network structure to stabilize a formulation comprising a high content of a cationic polymer, a formulation stabilizer provides Another aspect of the present disclosure provides a composition comprising an aqueous phase, wherein the aqueous phase includes a cationic polymer and a pH adjuster, and the pH of the aqueous phase is 4 to 6.5, to provide a composition for external application to the skin.

According to the present disclosure, the composition of the present disclosure may contain a cationic polymer in a high content, and thus, by sufficiently containing the cationic polymer, there is an effect of increasing the durability of the effective ingredient.

1 is a photograph confirming whether a gel network is formed in Examples and Comparative Examples.
Figures 2 and 3 are photographs showing the results of evaluation of the efficacy of ingredients in Examples and Comparative Examples.
Figure 4 is a graph showing the results of measuring the potency of the effective ingredients of Examples and Comparative Examples.

Terms used in this specification have been selected as currently widely used general terms as possible while considering the functions in the present disclosure, which may vary depending on the intention of those skilled in the art, precedents, or emergence of new technology. In addition, in a specific case, there is a term arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the description of the corresponding invention. Therefore, the terms used in the present disclosure should be defined based on the meaning of the term and the contents of the present disclosure, rather than the simple name of the term.

Unless defined otherwise, all terms used herein, including technical and scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms generally understood should be interpreted as having the same meaning as they have in the context of the related art, and are not to be interpreted in an ideal or excessively formal meaning unless explicitly defined in the present disclosure.

Numerical ranges are inclusive of the numerical values defined in this disclosure. Every maximum numerical limitation given throughout this specification includes all lower numerical limitations as if the lower numerical limitation were expressly written. Every minimum numerical limitation given throughout this specification includes all higher numerical limitations as if the higher numerical limitation were expressly written. Any numerical limitation given throughout this specification shall include all numerical ranges within the broader numerical range, as if the narrower numerical limitation were expressly written down.

Hereinafter, the present disclosure will be described in detail with reference to Examples and drawings. However, it is obvious that the present invention is not limited by the following examples and drawings.

In one aspect, the present disclosure provides a formulation stabilizer for stabilizing a gel network structure formulation by a cationic polymer comprising a pH adjusting agent as an active ingredient.

According to one embodiment of the present disclosure, the pH adjusting agent is an organic acid, a salt of an organic acid, an inorganic acid, a salt of an inorganic acid, or a combination thereof, and the organic acid is formic acid, acetic acid, propionic acid, lactic acid, butyric acid, isobutyric acid, trifluoroacetic acid , malic acid, maleic acid, malonic acid, fumaric acid, succinic acid, succinic acid monoamide, glutamic acid, tartaric acid, oxalic acid, citric acid, glycolic acid, glucuronic acid, ascorbic acid, benzoic acid, phthalic acid, salicylic acid, anthranilic acid, dichloroacetic acid, aminooxyacetic acid , benzenesulfonic acid, p-toluenesulfonic acid, and at least one selected from the group consisting of methanesulfonic acid, and the inorganic acid is at least one selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, carbonic acid and boric acid.

The "gel network" structure is formed due to the self-association of the cationic polymer and may contain a high content of the cationic polymer by the formulation stabilizer of the present disclosure, thereby stably forming a gel network. As a result, the composition of the present disclosure, which will be described later, has the effect of increasing the durability of the effective ingredient by sufficiently containing the cationic polymer.

According to one embodiment of the present disclosure, the gel network structure formulation contains the cationic polymer in an amount of 0.5% by weight or more based on the total weight of the formulation. More specifically, the cationic polymer is 0.5 wt% or more, 0.75 wt% or more, 1 wt% or more, 1.25 wt% or more, 1.5 wt% or more, 1.75 wt% or more, 2 wt% or more, based on the total weight of the formulation. , greater than 2% by weight, greater than 2.25%, greater than 2.5%, greater than 2.75%, greater than 3%, greater than 3.25%, greater than 3.5%, greater than 3.75%, greater than 4%; It may be included in an amount of 5 wt% or less, 4.75 wt% or less, 4.5 wt% or less, 4.25 wt% or less, 4 wt% or less, but is not limited thereto, and there may be no particular upper limit limitation.

According to one embodiment of the present disclosure, the formulation is a formulation including an aqueous phase, the aqueous phase includes a cationic polymer and the formulation stabilizer, the aqueous phase has a gel network structure, and the pH of the aqueous phase is 4 to It is 6.5.

In another aspect, the present disclosure provides a composition comprising an aqueous phase, wherein the aqueous phase includes a cationic polymer and the formulation stabilizer of the present disclosure, the aqueous phase has a gel network structure, and the pH of the aqueous phase is 4 to 6.5 Phosphorus, to provide a cosmetic composition.

In the case where a pH adjusting agent is not used without considering the pH of the aqueous phase in the composition, the cationic polymer cannot be included in a high content, and thus, the durability of the effective ingredient exhibited by sufficiently containing the cationic polymer is increased There are limits to what can be achieved. The cosmetic composition of the present disclosure may contain a cationic polymer in a high content by adjusting the pH of the aqueous phase within a specific range, and as such, it provides an effect of increasing the durability of the effective ingredient by sufficiently containing the cationic polymer. .

According to one embodiment of the present disclosure, the pH of the aqueous phase is 4 to 6.5. When the pH of the aqueous phase is within the above range, proper crosslinking occurs and the stability of the gel is excellent. More specifically, 4 or more, 4.2 or more, 4.4 or more, 4.6 or more, 4.8 or more, 5 or more, 5.2 or more, 5.3 or more; It may be less than 7, 6.9 or less, 6.8 or less, 6.7 or less, 6.6 or less, 6.5 or less, 6.4 or less, 6.2 or less, 6 or less, 5.8 or less, 5.6 or less, 5.4 or less, 5.3 or less, but is not limited thereto.

According to one embodiment of the present disclosure, the cationic polymer is included in an amount of 0.5% by weight or more based on the total weight of the composition. More specifically, the cationic polymer is 0.5 wt% or more, 0.75 wt% or more, 1 wt% or more, 1.25 wt% or more, 1.5 wt% or more, 1.75 wt% or more, 2 wt% or more, based on the total weight of the composition. , greater than 2% by weight, greater than 2.25%, greater than 2.5%, greater than 2.75%, greater than 3%, greater than 3.25%, greater than 3.5%, greater than 3.75%, greater than 4%; It may be included in an amount of 5 wt% or less, 4.75 wt% or less, 4.5 wt% or less, 4.25 wt% or less, 4 wt% or less, but is not limited thereto, and there may be no particular upper limit limitation in terms of durability of the effective ingredient. there is.

According to one embodiment of the present disclosure, the aqueous phase further includes an effective ingredient having a function for the skin, and the effective ingredient is a water-soluble ingredient or a poorly soluble ingredient. The “function on the skin” refers to functions such as whitening, moisturizing, blocking and absorbing UV rays, removing harmful oxygen, collagen synthesis, and preventing skin wrinkles, but is not limited thereto.

As the water-soluble effective ingredient contained in the aqueous phase, for example, as a wrinkle-improving functional raw material, a whitening functional raw material, etc., any one that can be dissolved in water to constitute the aqueous phase part may be used. More specifically, the wrinkle-improving functional raw material includes retinol, adenosine, and the like, and the whitening functional raw material includes arbutin, niacinamide, and the like. In addition, natural extracts such as plant extracts, animal extracts or mineral extracts extracted from green tea, ginseng, tangerine, ginkgo leaves, etc. may be used, but the present invention is not limited thereto. In addition, the water-soluble effective ingredient included in the aqueous phase may be any type of water-soluble vitamin that can be formulated in cosmetics, for example, vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, and nicotinic acid amide, folic acid, vitamin C, vitamin H or thiamine hydrochloride, sodium ascorbate salt, ascorbic acid-2-phosphate sodium salt, and ascorbic acid-2-phosphate magnesium salt. In addition, the water-soluble effective ingredient contained in the aqueous phase may be any type of high molecular peptide that can be formulated in cosmetics, for example, collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, and keratin. In addition, the water-soluble effective ingredient contained in the aqueous phase may be any kind of high molecular weight polysaccharide that can be formulated in cosmetics, for example, hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfuric acid or a salt thereof. .

The sparingly soluble ingredient contained in the aqueous phase means a hydrophobic substance that is difficult to disperse in water among substances that provide useful effects to the skin or body, for example, oleanolic acid, ursolic acid, and arjunolic acid. (triterpenoid) comprising at least one selected from the group consisting of (arjunolic acid); amentoflavone, ellagic acid, apigenin, berginin, diosmetin, univestin, resveratrol, isoflavones and Polyphenols or polyphenol derivatives comprising at least one selected from the group consisting of catechins; salicylic acid, alpha lipoic acid, caffeine, tocopherol, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and conjugates Oily fatty acids comprising at least one selected from the group consisting of linolenic acid (conjugated linolenic acid, CLA); sphingomyelin, ganglioside, cerebroside, ceramide, glycosyl ceramide, lactosyl ceramide, galactosyl ceramide and xyl sphingolipid comprising at least one selected from the group consisting of losyl ceramide; saponins including compound K; and carotene or carotene derivatives. In addition, natural extracts may also be used, but the present invention is not limited thereto. In addition, the sparingly soluble ingredient contained in the aqueous phase may be any type of fat-soluble vitamin that can be formulated in cosmetics, for example, vitamin A, carotene, vitamin D2, vitamin D3, vitamin E.

According to one embodiment of the present disclosure, the effective ingredient is included in an amount of 0.1% by weight or more based on the total weight of the composition in order to achieve the desired effect. More specifically, the cationic polymer is 0.1 wt% or more, 0.2 wt% or more, 0.3 wt% or more, 0.4 wt% or more, 0.5 wt% or more, 0.75 wt% or more, 1 wt% or more, based on the total weight of the composition. , 1.25 wt% or more, 1.5 wt% or more, 1.75 wt% or more, 2 wt% or more, 2.25 wt% or more, 2.5 wt% or more; 5% or less, 4.75% or less, 4.5% or less, 4.25% or less, 4% or less, 3.75% or less, 3.5% or less, 3.25% or less, 3% or less, 2.75% or less, It may be included in an amount of 2.5% by weight or less, but is not limited thereto, and there may be no particular upper limit limitation in terms of efficacy.

According to one embodiment of the present disclosure, the cationic polymer is a quaternary ammonium polymer. According to one embodiment of the present disclosure, the cationic polymer is polyquaternium 2, polyquaternium 4, polyquaternium 6, polyquaternium 7, polyquaternium 10, polyquaternium 11, polyquaternium 16, poly Quaternium 17, Polyquaternium 18, Polyquaternium 22, Polyquaternium 24, Polyquaternium 28, Polyquaternium 32, Polyquaternium 37, Polyquaternium 39, Polyquaternium 43, Polyquaternium 44, Poly at least one selected from the group consisting of quaternium 46, polyquaternium 47, polyquaternium 51, guar hydroxypropyltrimonium chloride and hydroxypropyl guar hydroxypropyltrimonium chloride.

According to one embodiment of the present disclosure, the pH adjusting agent is an organic acid, a salt of an organic acid, an inorganic acid, a salt of an inorganic acid, or a combination thereof, and the organic acid is formic acid, acetic acid, propionic acid, lactic acid, butyric acid, isobutyric acid, trifluoroacetic acid , malic acid, maleic acid, malonic acid, fumaric acid, succinic acid, succinic acid monoamide, glutamic acid, tartaric acid, oxalic acid, citric acid, glycolic acid, glucuronic acid, ascorbic acid, benzoic acid, phthalic acid, salicylic acid, anthranilic acid, dichloroacetic acid, aminooxyacetic acid , benzenesulfonic acid, p-toluenesulfonic acid, and at least one selected from the group consisting of methanesulfonic acid, and the inorganic acid is at least one selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, carbonic acid and boric acid.

According to one embodiment of the present disclosure, the pH adjusting agent is 0.01% by weight or more, 0.02% by weight or more, 0.03% by weight or more, based on the total weight of the composition to adjust the pH within the above range; 0.1% by weight or less, 0.09% by weight or less, 0.08% by weight or less, 0.07% by weight or less, 0.06% by weight or less, 0.05% by weight or less, 0.04% by weight or less, 0.03% by weight or less. not.

According to one embodiment of the present disclosure, the composition may be an emulsion that is a mixture of two or more liquids that do not fuse well. For example, the formulation of the composition may be oil in water (O/W) or water in oil (W/O). In addition, the formulation of the composition may be of multiple emulsion types such as water in oil in water (W/O/W) or oil in water in oil (O/W/O).

According to one embodiment of the present disclosure, the composition forms a gel network in the aqueous phase. The gel network is formed due to the self-association of the cationic polymer included in the aqueous phase, and the gel network is formed to prevent desorption of the effective ingredient, and the stability of the composition is increased. Therefore, when the cationic polymer is sufficiently contained, the durability of the effective ingredient can be increased.

According to one embodiment of the present disclosure, the composition further comprises an emollient. According to one embodiment of the present disclosure, the irritant reliever is a polyol. More specifically, the polyol may be at least one selected from the group consisting of glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, pentylene glycol and 1,2-hexanediol. The polyol includes a diol group capable of bonding with the cationic polymer, and thus provides an effect of alleviating skin irritation induced by the cationic polymer.

According to one embodiment of the present disclosure, the composition is a cosmetic composition. The cosmetic composition may be formulated by a conventional method. In the formulation of external skin preparations, reference may be made to the contents disclosed in Remington's Pharmaceutical Science, Mack Publishing Company, Easton PA, and in the formulation of cosmetic compositions, the Cosmetics, Toiletry and Fragrance Association You can refer to the contents disclosed in the published International Cosmetic Ingredient Dictionary.

Specifically, the cosmetic composition can be prepared in general emulsified formulations and solubilized formulations. For example, lotion, such as a softening lotion or a nourishing lotion; emulsions such as facial lotions and body lotions; creams such as nourishing creams, moisturizing creams, and eye creams; essence; makeup ointment; spray; gel; pack; sunscreen; makeup base; foundations such as liquid type, solid type or spray type; powder; makeup removers such as cleansing creams, cleansing lotions, and cleansing oils; Or it may be formulated as a cleaning agent such as a cleansing foam, soap, body wash. In addition, the external preparation for skin may be formulated as an ointment, patch, gel, cream or spray.

In the cosmetic composition, other ingredients may be appropriately blended within the range that does not impair the purpose of the present disclosure according to the type or purpose of use of the formulation in each formulation.

The cosmetic composition is a fatty substance, organic solvent, solubilizer, thickening agent, gelling agent, softening agent, antioxidant, suspending agent, stabilizing agent, foaming agent, and fragrance commonly used in the industry depending on the quality or function of the final product. , surfactants, water, ionic or nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, commonly used in cosmetics It may additionally contain adjuvants commonly used in the field of cosmetics or dermatology, such as any other ingredients.

According to one embodiment of the present disclosure, the composition is a pharmaceutical composition. In this case, a pharmaceutically acceptable carrier may be included. The carrier is used in the sense of including excipients, diluents or adjuvants. The carrier may be, for example, lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, polyvinyl pi It may be selected from the group consisting of rolidone, water, physiological saline, buffers such as PBS, methyl hydroxy benzoate, propyl hydroxy benzoate, talc, magnesium stearate, and mineral oil. The composition may include a filler, an anti-agglomeration agent, a lubricant, a wetting agent, a flavoring agent, an emulsifying agent, a preservative, or a combination thereof.

The pharmaceutical composition is administered in a pharmaceutically effective amount. The "pharmaceutically effective amount" means an amount sufficient to prevent or treat a disease at a reasonable benefit/risk ratio applicable, and the effective dose level depends on the patient's type of disease, the severity of the disease, the activity of the drug, and the drug. It can be determined according to factors including sensitivity, administration time, administration route and excretion rate, treatment period, concurrent drugs, and other well-known pharmaceutically.

The pharmaceutical composition may be prepared as a systemic formulation or a topical formulation, and in particular, it may be applied to the skin as an external preparation for the skin. The external preparation for skin may be in the form of a liquid, ointment, cream, lotion, spray, patch, gel, or aerosol formulation. When used as an external preparation for skin, in addition to fatty substances, organic solvents, solubilizers, thickening agents and gelling agents, emollients, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic types such as emulsifiers, fillers, sequestering and chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredients commonly used in external preparations for the skin. It may contain adjuvants commonly used in the field of dermatology. In addition, the above ingredients may be introduced in an amount generally used in the field of dermatology. The composition for external application for skin may further include an agent that increases transdermal absorption, for example, dimethyl sulfoxide, dimethylacetamide, dimethylformamide, surfactant, azone, alcohol, acetone, propylene glycol, or polyethylene glycol.

The pharmaceutical composition may be administered as an individual therapeutic agent or may be administered in combination with other therapeutic agents, may be administered sequentially or simultaneously with conventional therapeutic agents, and may be administered single or multiple. In consideration of all of the above factors, it is important to administer an amount that can obtain the maximum effect with a minimum amount without side effects, which can be easily determined by those skilled in the art. In addition, the pharmaceutical composition may be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, and biological response modifiers.

{Example}

Hereinafter, the present disclosure will be described in detail by way of Examples. However, the following examples are only examples to help the overall understanding of the present disclosure, and the content of the present disclosure is not limited to the following examples.

<Preparation Example> Preparation of Example 1 and Comparative Examples 1-5

Example 1 and Comparative Examples 1 to 5 were prepared with the composition shown in Table 1 below (unit: wt%)

division Comparative Example 1 Example 1 Example 2 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Ethylhexylmethoxycinnamate 6.5 6.5 6.5 6.5 6.5 6.5 6.5 Cyclopentasiloxane 20 20 20 20 20 20 20 PEG-10 Dimethicone 3 3 3 3 3 3 3 titanium dioxide 10 10 10 10 10 10 10 nylon powder One One One One One One One Disodium EDITA 0.02 0.02 0.02 0.02 0.02 0.02 0.02 hectorite One One One One One One One glycerin 3 3 3 3 3 3 3 Polyquaternium-10 0.5 0.5 5 - - - - Carbomer 980 - - - 0.5 0.5 - - xanthan gum - - - - - 0.5 0.5 citric acid - 0.03 0.03 - 0.03 - 0.03 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 pH 6.9 5.3 5.5 4.3 3.2 6.8 5.7

<Test Example 1> Check whether the gel network is formed in Examples and Comparative Examples 1

With respect to the Examples and Comparative Examples prepared in Preparation Example, it was confirmed whether the increase. The test was performed, including 1) applying 0.1 g of each of Examples and Comparative Examples to a black plate, and 2) visually checking the flow degree of Examples and Comparative Examples by standing the black plate vertically. The results are shown in Table 2 and FIG. 1 below.

division Comparative Example 1 Example 1 Example 2 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 gel network X O O X O O O

From the results of Figure 1, in the case of Example 1, in which the pH shows a value within the preferred range, it can be confirmed that the pH is increased to a high viscosity compared to Comparative Example 1 out of the preferred range, and it can be seen that a gel network is formed through this there is. In addition, from the results of Table 2, it can be confirmed that in Comparative Example 1 and Comparative Example 2 including an anionic polymer other than a cationic polymer, a gel network was not formed in which the pH was out of the preferred range.

<Test Example 2> Persistence evaluation 1 of the effective ingredients of Examples and Comparative Examples

For the Examples and Comparative Examples prepared in Preparation Example, the durability of the effective ingredient through the artificial leather adhesion was evaluated. Evaluation is performed by 1) applying 0.2 g of each of Examples and Comparative Examples to 5 cm X 5 cm artificial leather; 2) pretreatment for 3 hours in a 55°C thermostat; 3) applying a physical force by rotating 720° with a load of 2 kg; 4) The degree of erasing was carried out by performing the step of measuring the L value (brightness value) with a colorimeter. The results are shown in Table 3 below (when the degree of erasing is 70% or more, it is indicated by X, and when it is less than 70%, it is indicated by O).

division Comparative Example 1 Example 1 Example 2 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Artificial leather adhesion X O O X X X X

From the results of Table 3, it can be seen that Examples 1 and 2 containing a cationic polymer and showing a value within a preferred range of pH have excellent adhesion to artificial leather, and can be expected to have excellent durability of effective ingredients there is.

<Test Example 3> Persistence evaluation 2 of the effective ingredients of Examples and Comparative Examples

For Example 1 and Comparative Example 1 prepared in Preparation Example, the durability of the effective ingredient was evaluated. The test includes the steps of 1) applying 0.1 g of Example 1 and Comparative Example 1 to artificial leather and then performing primary washing, 2) performing secondary washing after dyeing with Rubine Dye for 3 minutes. was performed. After drying the artificial leather, the redness value was measured with a colorimeter. The results are shown in Table 4 and Figure 2 below.

division Comparative Example 1 Example 1 redness (a*) 2.78 12.04

From the results of Table 4 and Figure 2, in the case of Example 1, in which the pH is within a preferred range, the redness is about 4.3 times higher than in Comparative Example 1, where the pH is out of the preferred range, and it can be seen that the artificial leather adhesion is excellent. , it can be expected that the durability of the effective ingredient will be excellent.

<Test Example 4> Persistence evaluation 3 of the effective ingredients of Examples and Comparative Examples

For Example 1 and Comparative Examples 1 and 2 prepared in Preparation Example, the durability of the effective ingredient was evaluated. Evaluation is performed by 1) applying 0.2 g of each of Examples and Comparative Examples to 5 cm X 5 cm artificial leather; 2) pretreatment for 3 hours in a 55°C thermostat; 3) applying a physical force by rotating 720° with a load of 2 kg; 4) The step of measuring the degree of erasure as an L value (brightness value) with a colorimeter was performed. Persistence (%) was evaluated by comparing the brightness measurements before and after. The results are shown in Table 3 below. The results are shown in Table 5 and FIG. 3 below.

division Comparative Example 1 Example 1 Comparative Example 2 Durability (%) 85 95 72

From the results of Table 4 and FIG. 3, in the case of Example 1, in which the pH is within a preferred range, the adhesive strength of the artificial leather was higher than in Comparative Example 1, in which the pH was outside the preferred range, and Comparative Example 2 including the anionic polymer. It can be confirmed that it is excellent, and it can be expected that the durability of the effective ingredient is excellent.

<Test Example 5> Evaluation of skin irritation in Examples and Comparative Examples

For Example 1 and Comparative Examples 1 and 2 prepared in Preparation Example, skin irritation was evaluated. More specifically, Example 1 and Comparative Examples 1 and 2 were applied to 20 men and women aged 25 to 35 years, and the degree of stimulation (stinging, burning, etc.) felt by the subject after 10 minutes was measured from 0. It was rated on a 5-point scale (0 = no stimulation, 1 = very mild, 2 = mild, 3 = moderate, 4 = severe, 5 = very severe). The results are shown in Table 6 below.

division Comparative Example 1 Example 1 Comparative Example 2 degree of irritation 3.2 0.3 3.7

From the results of Table 6, in the case of Example 1, in which the pH shows a value within the preferred range, the degree of skin irritation is low compared to Comparative Example 1, in which the pH is out of the preferred range, and Comparative Example 2 including the anionic polymer can be checked

<Test Example 6> Measurement of potency of effective ingredients

For Example 1 and Comparative Examples 1 and 2 prepared in Preparation Example, the potency of the effective ingredient was measured. More specifically, with respect to the composition in which niacinamide, one of the active ingredients, was added in an amount of 2 wt%, the potency in a 40°C thermostat was measured monthly for a period of 6 months. Waters Symmetry C18 (length 7.5 cm x inner diameter 4.6 mm, 3.5 um) was used for the column, and an ethanol/water mixture (3:97) was used as the mobile phase, and the injection amount of the mobile phase was 10 ul and the flow rate was 1.0 ml/min. was done with The detector was analyzed using an ultraviolet absorbance spectrometer (HPLC-PDA system, Waters, measuring wavelength: 260 nm).

division Example 1 Comparative Example 1 Comparative Example 2 0 months 99.8 99 99.2 1 month 97.3 91.5 90.3 2 months 95.5 86.3 81.2 3 months 93.7 82.2 79.8 4 months 92.2 77.2 78.3 5 months 91.6 73.3 75.5 6 months 90.8 68.5 71.3

From the results in Table 7 and FIG. 4, in the case of Example 1, the titer was maintained at 90% or more up to 6 months under severe conditions, and from this, it can be confirmed that the potency of the effective ingredient is stable compared to Comparative Example 1 and Comparative Example 2. there is.

Although the present invention has been described with reference to the above-mentioned preferred embodiments, various modifications and variations are possible without departing from the spirit and scope of the invention. Accordingly, it is intended that the appended claims cover such modifications and variations as long as they fall within the scope of the present invention.

Claims (15)

containing a pH adjusting agent as an active ingredient,
A formulation stabilizer for stabilizing a gel network structure formulation with a cationic polymer. According to claim 1,
The pH adjusting agent is an organic acid, a salt of an organic acid, an inorganic acid, a salt of an inorganic acid, or a combination thereof,
The organic acids include formic acid, acetic acid, propionic acid, lactic acid, butyric acid, isobutyric acid, trifluoroacetic acid, malic acid, maleic acid, malonic acid, fumaric acid, succinic acid, succinic acid monoamide, glutamic acid, tartaric acid, oxalic acid, citric acid, glycolic acid, glucuric acid At least one selected from the group consisting of ronic acid, ascorbic acid, benzoic acid, phthalic acid, salicylic acid, anthranilic acid, dichloroacetic acid, aminooxyacetic acid, benzenesulfonic acid, p-toluenesulfonic acid and methanesulfonic acid,
The inorganic acid is at least one selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, carbonic acid and boric acid, formulation stabilizer. According to claim 1,
The formulation stabilizer, wherein the gel network structure formulation comprises a cationic polymer in an amount of 0.5% by weight or more based on the total weight of the formulation. According to claim 1,
The formulation is a formulation comprising an aqueous phase,
The aqueous phase comprises a cationic polymer and the formulation stabilizer,
The aqueous phase has a gel network structure,
The pH of the aqueous phase is 4 to 6.5, formulation stabilizer. A composition comprising an aqueous phase, comprising:
The aqueous phase comprises a cationic polymer and the formulation stabilizer of claim 1 or 2,
The aqueous phase has a gel network structure,
The pH of the aqueous phase is 4 to 6.5, the composition for external application to the skin. 6. The method of claim 5,
The cationic polymer is included in an amount of 0.5% by weight or more based on the total weight of the composition, composition. 6. The method of claim 5,
The aqueous phase further comprises an effective ingredient having a function for the skin, wherein the effective ingredient is a water-soluble ingredient or a poorly-soluble ingredient. 6. The method of claim 5,
wherein the cationic polymer is a quaternary ammonium polymer. 9. The method of claim 8,
The cationic polymer is polyquaternium 2, polyquaternium 4, polyquaternium 6, polyquaternium 7, polyquaternium 10, polyquaternium 11, polyquaternium 16, polyquaternium 17, polyquaternium 18, Polyquaternium 22, Polyquaternium 24, Polyquaternium 28, Polyquaternium 32, Polyquaternium 37, Polyquaternium 39, Polyquaternium 43, Polyquaternium 44, Polyquaternium 46, Polyquaternium 47, Polyquaternium 51, at least one selected from the group consisting of guar hydroxypropyltrimonium chloride and hydroxypropyl guar hydroxypropyltrimonium chloride. 6. The method of claim 5,
The formulation of the composition is a water-in-oil (W / O) type, composition. 6. The method of claim 5,
The composition forms a gel network in the aqueous phase. 6. The method of claim 5,
The composition further comprising an irritant reliever. 13. The method of claim 12,
wherein the irritant reliever is a polyol. 6. The method of claim 5,
The composition is a cosmetic composition, composition. 6. The method of claim 5,
The composition is a pharmaceutical composition.

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