JP2001131033A - Cosmetic for scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic which is used for scalp and hair, can persistently stimulate the activity of tyrosinase playing a fundamental role on the production of melamine in the hair and thereby has excellent effects for inhibiting the generation of gray hair and improving the gray hair. SOLUTION: This cosmetic for scalp and hair, characterized by containing (a) a tyrosinase activity-stimulating agent and (b) a topical stimulant.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic for scalp hair. More specifically, a tyrosinase activity promoter,
The present invention relates to a scalp and hair cosmetic composition containing a local stimulant and useful for improving white hair.

[0002]

BACKGROUND OF THE INVENTION Tyrosinase is found in human skin.
It is an indispensable enzyme for synthesizing melanin from tyrosine. It is known that this tyrosinase is deeply involved in the formation of "spots" and "freckles", which are phenomena caused by excessive exposure to sunlight or ultraviolet rays at sites such as the face and arms.

[0003] In addition, it has been revealed that this tyrosinase is deeply involved in the blackening of the scalp (darkening of the hair) in the scalp, and it has been revealed that the decrease in tyrosinase activity in the scalp is one of the causes of the graying of the hair. I have.

[0004] Attempts have been made to suppress the generation of gray hair or to improve it by promoting the activity of tyrosinase. As means for activating the production of melanin, Japanese Patent Application Laid-Open No. 5-7822 has been proposed.
No. 2, JP-A-7-285874, JP-A-7-285874
Japanese Patent Application Laid-Open No. 7-1129 discloses an invention described in Japanese Patent Application Laid-Open No. 316026 and a compound exhibiting both a hair growth effect and a gray hair prevention effect.
No. 78 and Japanese Patent Application Laid-Open No. 7-126129 have been proposed.

[0005]

However, in the inventions proposed in the prior art, blackening can be expected due to the high tyrosinase activity promoting effect, but since the effect is inferior in persistence, the generation of gray hair is visually impaired. There has been a problem that sufficient effects have not been obtained so as to be recognized as having suppressed or improved gray hair.

[0006] Further, even in the invention having both the hair-growth effect and the gray-hair-preventing effect, it is not always possible to obtain the same effect as a method of removing the white hair and making it inconspicuous and expected to grow into black hair. It was not effective in improving the quality.

As a result of the above-mentioned intensive studies, the present inventor has found that, among agents having a hair-growth effect, especially those having a local stimulating effect, the effect of a tyrosinase activity promoter represented by a salamander extract is effective. Is more sustainable,
The present inventors have found that a cosmetic for scalp and hair which is excellent in the effects of preventing gray hair generation and improving white hair can be obtained, and have completed the present invention.

[0008] An object of the present invention is to provide a scalp and hair for hair which is excellent in suppressing the generation of gray hair and improving gray hair by continuously promoting the activity of tyrosinase which plays a fundamental role in melanin production in hair. To provide cosmetics.

[0009]

That is, the present invention provides:
An object of the present invention is to provide a scalp / hair cosmetic comprising (a) a tyrosinase activity promoter and (b) a local stimulant.

In the present invention, the tyrosinase activity promoting agent (a) may be selected from the group consisting of a Japanese pepper (scientific name: Zanthoxylum piperi).
tum (L.) DC), cayulape (alias: Parameria laevigata, Kayu rapet, scientific name Parameria laevigata), guacomist (guaco misto, scientific name: Mykania Glomerata),
Pinguica (scientific name: Arctostaphylos Pugen)
s), Epazote (Scientific name: Chenopodium Ambros)
ioides L.), Zapote (scientific name: Poterium Zapote)
), Axcopaque (scientific name: Gautheria A)
cuminata), which is a solvent extract of one or more plants selected from the group consisting of:

Further, in the present invention, the (b) local stimulant is one or more selected from the group consisting of tincture tincture tincture, tincture tincture, carrot extract, menthol, camphor and nonylate vanillylamide. The above-mentioned cosmetic for scalp hair is provided.

Further, the present invention provides the scalp, wherein the content of the (a) tyrosinase activity promoter is 0.0001 to 10.0% by weight based on the total amount of the scalp hair cosmetic. A cosmetic for hair is provided.

Further, in the present invention, the content of the topical stimulant (b) is 0.001 to the total amount of the scalp hair cosmetic.
The present invention provides the scalp / hair cosmetic according to the above, characterized in that the amount is from 5.0 to 5.0% by weight.

Further, the present invention provides the scalp hair cosmetic, wherein the scalp hair cosmetic is an anti-grey hair cosmetic.

[0015]

Embodiments of the present invention will be described below.

The tyrosinase activity promoter (a) incorporated in the cosmetic for scalp and hair of the present invention may be a salt (scientific name:
Zanthoxylum piperitum (L.) DC), Kayurape (alias: Parameria laevigata, Kayu rapet, scientific name Parameria
laevigata), guaco misto (scientific name: Myka)
nia Glomerata), Pinguica (scientific name: Arcto)
staphylos Pugens), Epazote (scientific name: Ch)
enopodium Ambrosioides L.), Zapote (scientific name:
Poterium Zapote) and one or more tyrosinase activity promoters selected from the group consisting of Axcopaque (scientific name: Gautheria Acuminata).

Particularly preferred is a salmon extract. Salamander is an extract from salamander (Zanthoxylum piperitum (L.) DC) belonging to the genus Citrus spp., And can use fruits (peel), flowers, leaves, bark, and the like as raw materials. In particular, it is preferable to mix an extract from fruit (peel) with the cosmetic for scalp and hair of the present invention.

The salamander extract can be extracted by an extraction method generally used when extracting a plant-derived extract. That is, an extract (plant extract) can be obtained by subjecting the above-mentioned raw materials as they are or after drying them as necessary, and then subjecting them to solvent extraction as they are or pulverized.

The extraction solvent can be selected from those generally used when extracting its components from plants, and is not particularly limited. For example, hot water or water; lower alcohols such as ethanol, isopropyl alcohol and n-butanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrates of these alcohols; Hydrocarbon solvents and the like can be mentioned. When a lower alcohol such as ethanol is used as the extraction solvent, the obtained extract can be directly blended with the cosmetic for scalp and hair of the present invention. It is also possible to mix after drying, if necessary.

It is also possible to blend a commercially available sansho extract [Havex Sansha Extract (Koei Kogyo), Falco Rex Sansha (Ichimaru Falcos), Sansha Extract (Maruzen Pharmaceutical), etc. ].

The following plants can be obtained in a similar manner. Kayurape extract is an Indonesian herbal medicine, Kayu rape, belonging to the genus Parameria belonging to the family Oleander.
t (Parameria laevigata)), and it is possible to use leaves, stems, flowers, bark, seeds or fruits of the plant, whole plants, etc. as raw materials of the extract.

The guacomist extract is a Brazilian herbal medicine guacomist belonging to the genus Micania of the Compositae family.
o (mikania glomerafa), and it is possible to use leaves, stems, flowers, bark, seeds or fruits of the plant, whole plant, etc. as raw materials of the extract.

The extract of Ping squid is a medicinal herb belonging to the genus Rhododendron spp.
ctostaphylos pugens)), and leaves, stems, flowers, bark, seeds or fruits of the plant, whole plants, etc. can be used as raw materials for the extract.

The extract of Aritasou is a medicinal herb belonging to the genus Acazaceae (Epazote (Chenopodium A)
mbrosioides L.)), the leaves, stems, flowers, bark, seeds or fruits of the plant, whole plant, etc., can be used as raw materials for the extract, and the whole plant , Leaves and seeds can be used as this raw material.

The extract of Zapote is an extract from Zapote (Poterium zapote), a medicinal herb belonging to the genus Poterium, and extracts leaves, stems, flowers, bark, seeds or fruits, whole plants of the plant, etc. It can be used as a raw material for goods.

Axcopaque extract is a medicinal herb belonging to the genus Rhododendron sp.
paque (Gautheria acuminata)), and it is possible to use leaves, stems, flowers, bark, seeds or fruits of the plant, whole plant, etc. as raw materials of the extract.

The amount of the tyrosinase activity promoter (a), such as salmon extract, should be appropriately selected according to the dosage form and form of the scalp hair cosmetic, the extract concentration, and the like. Although it is not limited, 0.0001 to 10.0% by weight, preferably 0.0%, based on the total amount of the cosmetic.
005 to 5.0% by weight. If the amount of the extract is less than 0.0001% by weight with respect to the total amount of the cosmetic, the desired effect of preventing gray hair will not be sufficiently exhibited, and if it exceeds 10.0% by weight, there will be a formulation problem. There are cases. In addition, the above compounding amount is a weight percentage as a dried product or an extract after removing the extraction solvent.

As the topical stimulant (b) used in the cosmetic for scalp and hair together with the (a) tyrosinase activity promoter (b), for example, cantharis tincture, carrot extract, menthol, camphor and nonylate vanillylamide are used. And two or more kinds can be combined and compounded.

The cantaris tincture is a tincture obtained by extracting dried bean halibut with ethanol. Cantaris tincture is also known to have a skin stimulating action, a hair root stimulating action, a scalp stimulating action and the like, and is already commercially available (for example, Koei Kogyo, Shiseido Pharmaceutical, etc.).

[0030] Ginger tincture is a tincture obtained by extracting dried ginger with ethanol. It is also commercially available (eg, Ogi Pharmaceutical, etc.).

Examples of the carrot extract include hot water or water; lower alcohols such as ethanol, isopropyl alcohol and n-butanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrates of these alcohols; -Hexane, hydrocarbon solvents such as toluene and the like can be mentioned, but when a lower alcohol such as ethanol is used as the extraction solvent, the resulting extract can be directly blended in the scalp cosmetic of the present invention, It is also possible to remove the extraction solvent once and mix it after drying if necessary.

Menthol is an alcohol belonging to the monocyclic monoterpene, and is known to have a cool sedative effect, and has eight optically active substances and four inactive substances. l-
Menthol is a main component in mint oil, and all of them can be obtained by synthesis. These menthols are already commercially available (for example, Takasago flavor and the like), and in the cosmetic for scalp and hair of the present invention, 1-
Any of menthol and commercially available l-menthol, dl-menthol, etc. synthesized by a known method can be blended.

Camphor is one of the bicyclic monoterpene ketones, and is known to have a local stimulating action, a central stimulating action, an antiseptic action and the like. The camphor includes d-camphor, 1-camphor and dl-camphor.
Camphor and dl-camphor are commonly used. d
-Camphor is obtained by steam distillation of pieces contained in camphor and the like, and dl-camphor is obtained by a known method, for example, synthesis from pinene. These camphors are already commercially available (for example, Nippon Seika, Ogi Pharmaceutical, Nippon Terpene Chemical, etc.), and in the cosmetic for hair of the present invention,
D-Camphor obtained from a piece such as camphor tree and dl-camphor synthesized by a known method, as well as commercially available d-camphor and dl-camphor, can be blended.

Nonylic acid wanilylamide is a compound having a structure represented by the following chemical formula 1 and has a white to white property.
A whitish crystalline powder with a slight peculiar odor. It has a skin stimulating action and a peripheral vasodilating action, and is known to be used as an external preparation for muscle pain, neuritis, sciatica and the like. The production method of nonyl acid wanilylamide is not known, but is commercially available (for example, Matsumoto Trading).

[0035]

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(B) The amount of the topical stimulant should be appropriately selected according to the dosage form and form of the cosmetic for scalp and hair, and is not particularly limited. In contrast, the content is preferably 0.001 to 5% by weight,
It is particularly preferred that the content be from 0.01 to 5.0% by weight. The amount of the local stimulant is 0.001% by weight based on the total amount of the cosmetic.
If the amount is less than the above, the desired effect of preventing gray hair is not sufficiently exhibited, and it is not preferable. If the amount exceeds 10.0% by weight, unpleasant irritation may be given on the preparation or on the scalp or hormonal action may be exhibited. . When the topical stimulant is a solvent extract of a plant, it is expressed in terms of% by weight as a dried product or an extract after removing the extractant.

In this way, by combining the tyrosinase activity promoter and the local stimulant in combination, the scalp is extremely superior in preventing or inhibiting the development of gray hair as compared with the case where the tyrosinase activity promoter is blended alone. A hair cosmetic is provided.

The scalp and hair cosmetic composition of the present invention comprises a general base ingredient and a medicinal ingredient which can be blended with ordinary skin cosmetics or hair cosmetics, into specific cosmetic formulations and forms. Accordingly, they can be blended as long as the desired effect in the dosage form or form is not impaired.

Specifically, diluents, surfactants, higher alcohols, oils, humectants, thickeners, solvents, usability improvers, preservatives, antioxidants, sequestering agents, ultraviolet protective agents, Powder components, various chemicals, coloring agents, fragrances, and the like can be appropriately selected and blended according to the intended dosage form and form.

Examples of the diluent include water, ethanol, isopropyl alcohol, glycols and the like.

Among the surfactants, examples of the anionic surfactant include alkyl benzene sulfonate, polyoxyalkylene alkyl sulfate, alkyl sulfate, olefin sulfonate, alkyl phosphate, and polyoxyalkylene alkyl. Examples thereof include ether phosphates, dialkyl sulfosuccinates, and fatty acid salts. Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, polyglycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil derivative. And fatty acid diethanolamide. Examples of the cationic surfactant include a tertiary aliphatic amine salt, an alkyltrimethylammonium halide, a dialkyldimethylammonium halide and the like. Examples of the amphoteric surfactant include amidobetaine type, imidazolinium betaine type, and sulfobetaine type amphoteric surfactants.

Examples of the higher alcohol include cetyl alcohol, stearyl alcohol, behenyl alcohol and the like.

Examples of the oil component include higher fatty acids, solid paraffin, liquid paraffin, silicone oil, high molecular silicone and derivatives thereof, squalane, petrolatum, ester oil and the like.

Examples of the humectant include glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol and the like.

Examples of the thickener include methylcellulose, hydroxyethylcellulose, carrageenan, carboxymethylcellulose, and cationized cellulose.

As the solvent, for example, water, ethanol,
Examples thereof include isopropyl alcohol and benzyl alcohol.

Usability improvers include, for example, methylpolysiloxane, methylaminopropylsiloxane and the like.

Examples of the preservative include benzoic acid, dehydroacetic acid, paraoxybenzoic acid esters (eg, methyl paraoxybenzoate, butyl paraoxybenzoate), and phenoxyethanol.

Examples of the antioxidant include ascorbic acid and BHA.

Examples of the sequestering agent include ethylenediaminetetraacetic acid (edetic acid), tripolyphosphate and the like.

Examples of the ultraviolet protective agent include oxybenzone and butylmethoxybenzoylmethane.

Examples of the powder component include powder resins such as silica, nylon powder and polyethylene powder.

Various drugs include, for example, plant extracts such as Bacillus extract; vitamins other than vitamin Es such as vitamin B6 and biotin; pantothenic acid and derivatives thereof;
Glycyrrhizic acid and its derivatives; amino acids such as serine and methionine; nicorandil and cyclosporic acid;
And female hormones such as estradiol.

Other compoundable components include, for example,
Antibacterial agents such as allantoin, ictamol, azulene, guaiazulene, epsilon aminocaproic acid, lysozyme chloride, diphenhydramine hydrochloride, glycyrrhetinic acid and derivatives thereof; , Zinc and its derivatives, lactic acid and its alkyl esters, and the like; and organic acids such as citric acid.

Any one or more of the above mixable components are mixed together with the essential components of the present invention, and a cosmetic for scalp and hair is produced by a conventional method.

The dosage form of the scalp hair cosmetic composition of the present invention may be any liquid, emulsion, ointment or any other form applicable to the skin or scalp, and is generally a lotion, cream, oil, gel or the like. , Hair tonic, hair liquid, treatment, aerosol mousse, aerosol spray and the like. In addition, the cosmetic for scalp hair of the present invention can be applied in the fields of pharmaceuticals and quasi-drugs.

The scalp hair cosmetic composition of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin.
The dose should be appropriately determined according to age, individual differences such as the degree of gray hair, and its dosage form and form, but the dose for general adults is 25 to 150 mg per kg of body weight.
/ Day, preferably 50 to 100 mg / day, which can be administered once a day or divided into 2 to 4 times a day.

[0058]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples, but these should not be construed as limiting the technical scope of the present invention. In addition, the compounding amount in these Examples and the like is a percentage by weight based on the entire system in which the component is compounded, unless otherwise specified.

[Preparation of Sansha Extract] 500 g of perilla peel was immersed in ethanol at room temperature for one week, and ethanol in the extract was distilled off to obtain 9.7 g of a sansho extract. In the test examples and prescription examples described below,
This extract was used as a "salmon extract".

[Preparation of Kayurape extract] Ethanol was immersed in 500 g of Kayurape at room temperature for 1 week at room temperature, and ethanol in the extract was distilled off to obtain 10.3 g of Kayurape extract. In the test examples and formulation examples described below, this extract was used as “Cayulabe extract”.

[Preparation of Guacomist Extract] 500 g of whole guac mist was immersed in ethanol at room temperature for one week, and ethanol in the extract was distilled off to obtain 10.1 g of a guac mist extract. In the test examples and formulation examples described below, this extract was used as “guacomist extract”.

[Preparation of Ping squid extract] 500 g of Ping squid whole plant was immersed in ethanol at room temperature for 1 week, and ethanol in the extract was distilled off to obtain 9.3 g of Ping squid extract. In the test examples and formulation examples described below, this extract was used as “Ping squid extract”.

[Preparation of an extract of Arita saury] 500 g of an alfalfa whole plant was immersed in ethanol at room temperature for one week, and ethanol in the extract was distilled off to obtain 9.3 g of a Pinca squid extract. In the test examples and formulation examples described below, this extract was used as “Arysassin extract”.

[Preparation of Zapote Extract] Zapote Whole Plant 500
g of the extract was immersed in ethanol at room temperature for one week, and ethanol in the extract was distilled off to obtain 9.9 g of a Zapote extract. In the test examples and formulation examples described below, this extract was used as “Zapote extract”.

[Preparation of Axcopaque extract] 500 g of Axkopaque whole plant was soaked in ethanol for 1 week at room temperature.
Ethanol in this extract was distilled off to obtain 9.3 g of a squid extract. In the test examples and formulation examples described below, this extract was used as “Axcopaque extract”.

[Preventive or Inhibitory Effect of Human Gray Hair Development by Cumulative Application] <Test Method> Twenty times a day (morning, night) )
For 4 months in a row, separate lotions were applied to the left and right crowns by the half-head method, and the number of white hairs per 1000 hairs on the left and right crowns was counted before and 4 months after the start of application, and white hair was generated. The preventive or inhibitory effect of was investigated.

<Judgment Criteria> +++: 50% or more of the subjects have less than 70% of the number of white hairs after application with respect to the number of white hairs before application. (Very effective) ++: 50% or more of test subjects have 70% or more and less than 80% of the number of white hairs after application with respect to the number of white hairs before application. (Remarkable effect) +: 50% or more of the subjects had 80% or more and less than 90% of the number of white hairs after application with respect to the number of white hairs before application. (Effective) ±: 50% or more of the subjects had 90% or more and less than 100% of the number of white hairs after application with respect to the number of white hairs before application. (Slightly effective)-: Less than 50% of test subjects have 90% or more and less than 100% of the number of white hairs after application with respect to the number of white hairs before application. (Invalid)

Each lotion was prepared according to the formulation shown in Table 1 according to the following method. <Production method> A plant extract and succinic acid were added to purified water and uniformly dissolved. Other raw materials were dissolved in ethanol and added to the aqueous phase to dissolve.

[0069]

[Table 1]

[0070]

[Table 2]

From the results shown in Tables 1 and 2, Comparative Examples 1 to 7 in which only the tyrosinase activity enhancer was blended had the effect of preventing or suppressing the generation of gray hair, but Examples 1 to 5 in which a local stimulant was blended. It has been found that has a better effect of preventing or suppressing the generation of gray hair than Comparative Example 1. In addition, it was also revealed that even if only a local stimulant was added without adding a salmon extract, no effect of preventing or suppressing the generation of gray hair was observed (Comparative Examples 8 to 13).

That is, in the lotion of the present invention in which a local stimulant is combined with a tyrosinase activity promoter (Examples 1 to 9), it is apparent that a synergistic effect of preventing or suppressing the generation of gray hair is remarkably observed. It became. This indicates that the desired effect can be obtained only by using a small amount of salamander extract and a local stimulant.

Examples of other formulations of the scalp hair cosmetic composition of the present invention are described below. In addition, also about these examples, when the prevention or suppression effect of the above-mentioned human gray hair development was examined, in any of the examples, "effective"-
"Very effective" results were obtained.

Example 10 Hair Tonic (Blending Components) Blending Amount (% by Weight) (1) POE Sorbitan Monooleate (20 M Adduct) 1.0 (2) Sansho Extract 1.0 (3) 95% ethanol 50.0 (4) Salmon tincture 0.1 (5) Citric acid 0.002 (6) Sodium citrate 0.05 (7) Perfume appropriate amount (8) Purified water balance

<Manufacturing method> (1), (4) and (7)
Was added and dissolved by stirring. Then, (2) and (5) were added to (8).
(6) was added, and the mixture dissolved by stirring was added to obtain a hair tonic.

Example 11 Hair Tonic (Blending Components) Blending Amount (% by Weight) (1) Propylene Glycol 3.0 (2) L-Menthol 0.5 (3) Guacomist Extract 5.0 (4) 95 % Ethanol 70.0 (5) Cantharis tincture 0.01 (6) Perfume appropriate amount (7) Purified water

<Manufacturing method> (1), (2) and (5)
After adding (6) and stirring and dissolving, (3) was added to (7), and the resulting solution was stirred and dissolved to obtain a hair tonic.

Example 12 Hair Tonic (Blending Components) Blending Amount (% by Weight) (1) Polyethylene Glycol 2.0 (2) D-Camphor 0.3 (3) Kayupera Extract 0.005 (4) 95 % Ethanol 40.0 (5) Polyoxyethylene hydrogenated castor oil (10EO, 20PO adduct) 2.0 (6) Carrot extract 0.01 (7) Perfume appropriate amount (8) Purified water balance

<Manufacturing Method> (1), (2) and (5)
(6) After adding (7) and stirring and dissolving, (3) was added to (8) and the resulting solution was stirred and dissolved to obtain a hair tonic.

Example 13 Hair Liquid (Blending Components) Blending Amount (% by Weight) (1) Polyoxypropyl butyl ether (40PO) 20.0 (2) Polyoxypropyl butyl ether phosphoric acid (40PO) 5.0 (3 ) Salmon extract 0.001 (4) D-camphor 0.3 (5) Glycerin 1.0 (6) 95% ethanol 55.0 (7) Glycerin tri-2-ethylhexylate 0.5 (8) Fragrance Appropriate amount (9) Dye appropriate amount (10) Lactic acid appropriate amount (11) Purified water balance

<Manufacturing Method> (1), (2) and (4)
(5) After adding (7) and (8) and dissolving with stirring, (1)
To (1), (3), (9), and (10) were added, and the mixture was stirred and dissolved to obtain a hair liquid.

[Example 14] Scalp treatment (Blending components) Blending amount (% by weight) (1) 1,3-propylene glycol 1.5 (2) Erythritol 1.0 (3) 95% ethanol 60.0 (4 ) Zapote extract 1.0 (5) L-menthol 0.6 (6) Flavor appropriate amount (7) Purified water appropriate amount (8) Dimethyl ether appropriate amount

<Manufacturing method> (1), (2) and (4)
(5) After adding (6) and stirring and dissolving, (7) was added to prepare a stock solution. The can was filled with the undiluted solution, and after mounting the valve, (8) was filled to obtain a scalp treatment.

Example 15 Hair Cream (Blending Components) Blending Amount (% by Weight) <A Phase> (1) Liquid Paraffin 8.0 (2) Cetostearyl Alcohol 5.5 (3) Vaseline 5.5 (4) ) Glyceryl monostearate 3.0 (5) Sorbitan monooleate 3.0 (6) Nonilic acid vanillylamide 0.5 (7) Tocophenol acetate 1.0 (8) Butylparaben 0.2 (9) Perfume 3 <Phase B> (10) Ping squid extract 1.0 (11) Glycerin 5.0 (12) Dipropylene glycol 20.0 (13) Polyethylene glycol 1500 5.0 (14) Sodium hexametaphosphate 0.005 (15 ) Purified water balance

<Production method> (1) to (9) were mixed and dissolved by heating to prepare phase A. Separately, (10) to (15) were mixed and dissolved by heating to prepare phase B. Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.

Example 16 Hair Gel (Ingredients) Amount (% by weight) (1) Carboxyvinyl polymer 0.45 (2) Xanthan gum 0.2 (3) Polyvinylpyrrolidone 3.0 (4) Sorbitol 2.0 (5) Axcopaque extract 0.001 (6) Suitable amount of sodium hydroxide (7) Ethanol 15.0 (8) Suitable amount of polyoxyethylene octyl dodecyl ether (9) L-camphor 2.0 (10) Perfume proper amount (11) Edetic acid qs (12) Purified water balance

<Manufacturing method> (1) (2) (3) (4)
(5) (11) was dissolved in (12). (8) (9)
(10) was dissolved in (7). This was added to the above parts with stirring, and then (6) was added to increase the viscosity to obtain a hair gel.

[Example 17] Hair spray (stock solution formulation) Compounding amount (% by weight) (1) Acrylic resin alkanolamine salt 10.0 (2) Cetanol 0.1 (3) Dodecamethylpolysiloxane 0.5 (4 ) Ethanol stock solution residue (5) Salmon extract 0.01 (6) Flavor appropriate amount (7) L-menthol 0.01 (filling formulation) (8) Stock solution 60.0 (9) Dimethyl ether 35.0 (10) LPG 5.0

<Production method> (1) to (3), (5) to
(7) was dissolved in (4) to prepare a stock solution. The stock solution (8) was filled in a can, and after the valve was mounted, (9) and (10) were filled to obtain a hair spray.

[0090]

According to the present invention, there is provided a cosmetic for scalp hair which is extremely useful for preventing and preventing the occurrence of gray hair and which is excellent in safety.

Continuation of the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (Reference) A61K 45/06 A61K 45/06 A61P 17/00 A61P 17/00 43/00 105 43/00 105 111 111 (72) Invention Person Eiji Ifuku 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture F-term in the Shiseido Daiichi Research Center Co., Ltd. AD072 AD092 AD162 AD352 AD531 AD532 AD652 BB51 BB53 CC31 CC33 DD08 DD27 DD31 DD41 EE24 4C084 AA20 CA13 CA59 NA05 ZA921 ZA922 ZB222 ZC191 ZC192 4C088 AB12 AB40 AB62 AC04 AC05 AC11 BA08 MA63 NA05 ZA92 ZB02 ZA03 MA03 4B ZC19

Claims (6)

[Claims] (A) a tyrosinase activity promoter,
(B) A cosmetic for scalp hair, comprising a topical stimulant. 2. The tyrosinase activity promoter (a),
Salmon (scientific name: Zanthoxylum piperitum (L.) DC),
Kayurape (aka; Parameria Laevigata, Kayu rap)
et, scientific name Parameria laevigata, guaco mist (guaco
misto, Scientific name: Mykania Glomerata, Ping squid (Pin)
guica, Scientific name: Arctostaphylos Pugens, Aritasou (Epazote, Scientific name: Chenopodium Ambrosioides L.), Zapote (Zapote, Scientific name: Poterium Zapote), Axcopaque (Axcopaque, Scientific name: Gautheria Acuminata) The scalp hair cosmetic according to claim 1, which is a solvent extract of the above plant. 3. The local stimulant (b) is one or more selected from the group consisting of tincture tincture tincture, tincture tincture, carrot extract, menthol, camphor and nonylate wanilylamide. The scalp hair cosmetic according to claim 1. 4. The content of the (a) tyrosinase activity promoter is 0.0001 to 0.0001 of the total amount of the scalp hair cosmetic.
The scalp hair cosmetic according to claim 1, 2 or 3, which is 10.0% by weight. 5. The method according to claim 1, wherein the content of the topical stimulant (b) is 0.001 to 5.0% by weight based on the total amount of the scalp hair cosmetic. 4. The cosmetic for scalp hair according to 4. 6. The scalp hair cosmetic composition is an anti-grey-hair cosmetic composition.
The scalp hair cosmetic according to the above.