KR20220059238A - Liquid crystal-stabilized water-in-oil emulsion with low viscosity - Google Patents

Abstract

The present invention relates to a low-viscosity water-in-oil cosmetic composition, wherein the composition contains two or more polyglyceryl-based surfactants having different molecular weights to make droplets of the emulsion small and uniform in size, and to form more durable liquid crystals on the surface of the droplets, thereby having excellent formulation stability. In addition, since the low-viscosity water-in-oil cosmetic composition is light and non-sticky when applied to the skin due to low viscosity, and has an effect corresponding to the feeling of use of oil-in-water (O/W) cosmetics.

Description

Liquid crystal emulsion-based low-viscosity water-in-oil cosmetic composition {Liquid crystal-stabilized water-in-oil emulsion with low viscosity}

It relates to a low-viscosity water-in-oil cosmetic composition.

In general, a water-in-oil cosmetic is a form in which emulsion droplets of an aqueous phase are dispersed in an oil phase, and since the continuous phase is oil, it has excellent water resistance and is mainly applied to sun care or base makeup products that are strong against water or sweat. However, since the trauma is composed of an oily phase, the oil molecules of the trauma reduce the function of the surfactant adsorbed on the emulsion droplet interface, thereby reducing the stability of the emulsion system. There is a problem that the feeling of use is unpleasant, such as not good. In addition, if the content of the oil phase, which is traumatic, is increased in order to improve the stability of the water-in-oil type cosmetic, another problem occurs that the oily feeling of use increases. To solve this problem, the amount of emulsifier was forcibly added or the emulsification time and RPM of the emulsifying system were increased to break up the droplets of the water phase.

However, in order for the water-in-oil-type low-viscosity emulsion to retain competitiveness in the cosmetic market, it is necessary to develop cosmetics that maintain formulation stability while solving the problems of the existing water-in-oil type emulsion using a minimum amount of surfactant.

One aspect is an oil phase containing two or more polyglyceryl-based surfactants having different molecular weights; And it is to provide a cosmetic composition of an emulsion formulation comprising an aqueous phase containing a polyol, the crystal structure of which is a lamellar structure.

Another aspect is an oil phase containing two or more polyglyceryl-based surfactants having different molecular weights; and an aqueous phase portion containing polyol, and to provide a composition for external application for skin in an emulsion formulation having a lamellar crystal structure.

One aspect is an oil phase containing two or more polyglyceryl-based surfactants; And it provides a cosmetic composition of an emulsion formulation comprising an aqueous phase containing a polyol, the crystal structure of which is a lamellar structure. In one embodiment, the cosmetic composition comprises: an oil phase containing a low molecular weight polyglycerin-based surfactant and a high molecular weight polyglycerin-based surfactant; It may be an emulsion cosmetic composition comprising an aqueous phase containing polyol and having a lamellar crystal structure. The stratum corneum is present in the epidermis, which is located at the outermost part of the skin, and acts as a skin barrier to protect the human body from various external stimuli. The stratum corneum is composed of several layers of flat-shaped keratinocytes, hydrophobic insoluble fibrous protein called keratin fills the keratinocytes, and intercellular lipids composed of ceramide, free fatty acids, cholesterol, etc. fill the spaces between the keratinocytes. It has a lamellar structure. Due to these structural features, evaporation of moisture from the skin is suppressed and the human body can be effectively protected from external stress or harmful stimuli, but there is a problem in that the active ingredients of cosmetics are also not easily absorbed. However, the composition according to one aspect forms a lamellar structure similar to that of the stratum corneum of the skin, and thus has excellent skin affinity, so it can be used to improve skin condition or improve skin beauty. For example, the skin condition or skin beauty improvement may be skin aging inhibition or improvement, skin soothing, skin barrier strengthening, or skin moisturizing.

The surfactant is a lipophilic surfactant, and a hydrophilic-lipophile balance (HLB) value of 7 or less, for example, 2 to 6, may be a polyglyceryl-based surfactant. Specifically, the low molecular weight polyglycerin-based surfactant has a molecular weight of 1,000 g/mol or less, for example, polyglyceryl-4 isostearate, polyglyceryl-2 diisostearate, polyglyceryl- 2 isostearate, polyglyceryl-5 hexastearate, polyglyceryl-10 heptaoleate, polyglyceryl-10 pentastearate, or polyglyceryl-10 decastearate. In addition, the high molecular weight polyglycerin-based surfactant has a molecular weight of greater than 1,000 g/mol and less than or equal to 10,000 g/mol, for example, polyglyceryl-6 polyhydroxystearate, polyglyceryl-10 polyhydroxy Stearate, polyglyceryl-3 polyricinoleate, polyglyceryl-4 polyricinoleate, polyglyceryl-5 polyricinoleate, polyglyceryl-6 polyricinoleate, or polyglyceryl-10 poly It may be ricinoleate or the like. In one embodiment, the low molecular weight and high molecular weight polyglycerin-based surfactant may be mixed in a weight ratio of 1:10 to 10:1. For example, 1:10 to 10:1, 1:9 to 9:1, 1:7 to 7:1, 1:6 to 6:1, 2:7 to 7:2, 3:6 to 6: It may be mixed in a weight ratio of 3 or 5:5. At this time, when the mixing ratio of the low molecular weight and high molecular weight polyglycerin-based surfactant is less than the above range, the formulation stability of the emulsion formulation is not maintained and unstable, and there is a problem that phase separation occurs in the oil phase and the aqueous phase. When it exceeds, there is a problem that the viscosity increases and the feeling of use is unpleasant. In one embodiment, polyglyceryl-2 isostearate (HLB 5.5, molecular weight 450 g/mol) and polyglyceryl-6 polyricinolate (HLB 4.7, molecular weight 4,500 g/mol) are mixed in a weight ratio of 2.4: 0.5 It was confirmed that the mixed cosmetic composition was stable at low and high temperatures without phase separation between the oil phase and the aqueous phase. That is, in the composition according to an aspect, the low molecular weight polyglycerin participates in the emulsion droplet size and uniform monodieperse index in the lamellar structure of the liquid crystal emulsion, and the high molecular weight polyglycerin participates in the viscosity of the emulsion. And formulation stability can be improved through the mutual complementation of a high molecular weight polyglycerin-based surfactant.

In addition, the surfactant may be contained in an amount of 0.5 to 4.5% by weight based on the total weight of the composition. For example, it may be contained in an amount of 0.5 to 4.5 wt%, 0.5 to 4.0 wt%, 0.5 to 3.5 wt%, 0.5 to 2.0 wt%, 1.0 to 3.5 wt%, 1.5 to 2.5 wt%, or 2.0 to 2.5 wt% there is. At this time, when the content of the surfactant is less than the above range, there is a problem that formulation stability cannot be maintained. .

As used herein, the terms "polyol" and "polyhydric alcohol" are used interchangeably and refer to an aliphatic compound having two or more hydroxyl groups (-OH). The polyol may be glycerol, glycols, sorbitol, or a combination thereof. The glycerol may be glycerin, diglycerin, polyglycerin, glyceritol, glycyl alcohol, or a combination of two or more thereof. The glycerin may be used interchangeably with other commonly used names such as lysline, propane-1,2,3-triol, 1,2,3-propenetriol, and trihydroxypropane. The glycols may be propylene glycol, dipropylene glycol, butylene glycol, diethylene glycol, triethylene glycol, hexylene glycol, pentylene glycol, polyethylene glycol, methylpropanediol, or a combination of two or more thereof. The polyol may be included in an amount of 3.0 to 40% by weight based on the total composition. For example, 3.0-40 wt%, 3.0-35 wt%, 3.0-30 wt%, 3.0-25 wt%, 3.0-20 wt%, 10-40 wt%, 10-30 wt%, 10-20 wt% %, 5.0 to 20% by weight, or 5.0 to 10% by weight. At this time, when the content of the polyol is less than the above range, it is not sufficient to moisturize the skin, and the temperature stability of the formulation is poor, and there is a problem in that the phases of the oil phase and the water phase are separated. There is a problem in that the feeling of use is unpleasant. That is, the polyol may be used to prevent phase separation due to freezing point lowering as well as moisturizing effect.

As used herein, the term "viscosity" is a measure of the resistance of a fluid when its shape changes or the property of parts that are attached to each other not to fall off. If the liver measured value is less than 8,000 cPs, it is defined as low. Accordingly, the cosmetic composition according to an aspect may be a low-viscosity emulsion composition having a viscosity of 2,000 cPs to 8,000 cPs. For example, the composition may have a viscosity of 2,000 cPs to 8,000 cPs, 2500 cPs to 8,000 cPs, 3,000 cPs to 8,000 cPs, 4,000 cPs to 8,000 cPs, 3,500 cPs to 7,000 cPs, 4,000 cPs to 6,500 cPs, or 5,000 cPs to 6,000 cPs. may be

In one embodiment, the cosmetic composition comprises an oil and a suspending agent in the oil phase; And it may further include a salt in the aqueous phase. The type of oil is not limited as long as it is an oil commonly used in cosmetics. For example, the oil may be at least one selected from the group consisting of ester oil, hydrocarbon oil, silicone oil, vegetable oil, and triglycerides.

The ester-based oil may be an ester compound of a fatty acid and a fatty alcohol. For example, the ester-based oil is isopropyl myristate (Isopropyl Myristate), isopropyl palmitate (Isopropyl Palmitate), cetyl octanoate (Cetyl Octanoate), cetyl 2-ethyl hexanoate (Cetyl 2-Ethyl Hexanoate) , 2-Octyl Dodecyl Myristate, Di-isostearyl Malate, and the like.

The hydrocarbon-based oil may include petroleum oils such as liquid paraffin, vaseline, and isoparaffins; synthetic oils such as hydrogenated polydecene, synthetic squalane, and polybutene; Vegetable oils such as vegetable squalane and hydrogenated squalane may be included.

The silicone-based oil may be an oil having a siloxane bond (Si-O-Si). For example, the silicone-based oil is dimethicone, dimethiconol, phenyl trimethicone, disiloxane, cyclomethicone, cyclopentasiloxane, Cyclohexasiloxane (Cyclohexasiloxane) and the like may be included.

The vegetable oil may be an oil obtained from a plant existing in nature. For example, the vegetable oil is olive oil, meadowfoam seed oil, rosehip fruit oil, avocado oil, camellia oil, apple seed oil, grape seed oil, sunflower seed oil, macadamia seed oil, castor oil, jojoba seed oil, capryl lyx/capric triglycerides and the like.

The salt is a component for controlling the freezing point, and for example, sodium chloride (NaCl), magnesium sulfate (MgSO ₄ ), potassium chloride (KCl), calcium chloride (CaCl ₂ ), or a combination thereof.

In addition, the cosmetic composition may be an O/W (water-in-oil) emulsion formulation. However, the formulation is not particularly limited, and may include cosmetic composition formulation components commonly used in the technical field to which the invention pertains depending on the formulation to be prepared. The cosmetic composition of the present invention may be formulated as, for example, a liquid product, lotion, essence, cream, sun lotion, sun cream, makeup base, foundation, BB cream, stick product, or balm type product, etc. However, the present invention is not limited thereto. In addition, oil, water, surfactant, humectant, lower alcohol, thickener, chelating agent, preservative, fragrance, etc. may be selected and added according to the formulation to be prepared. In addition, it may include a sunscreen, a light scattering agent, and the like, and the formulation and additive components are not limited thereto. In addition, the above ingredients may be introduced in an amount generally used in the field of dermatology.

The cosmetic composition may contain additional ingredients commonly used in cosmetics, such as thickeners, dispersants, fragrances, fillers, preservatives, preservatives, neutralizers, sweeteners, vitamins, free-radical scavengers, sequestering agents, functional ingredients and these It may further include any conventional cosmetic ingredients that can be selected from a mixture of

A person skilled in the art can select any additional ingredients and/or amounts thereof such that the advantageous properties of the composition according to the present disclosure are not adversely or substantially not adversely affected by the expected addition.

Another aspect is an oil phase containing two or more polyglyceryl-based surfactants having different molecular weights; and a polyol-containing aqueous phase, wherein the crystal structure is a lamellar structure. The external preparation for skin may be a composition for transdermal delivery of a drug (physiologically active substance). Specific details of the composition for external application for skin are the same as described above.

In the present specification, the external preparation for skin may be a cream, gel, ointment, skin emulsifier, skin suspension, transdermally delivered patch, drug-containing bandage, lotion, or a combination thereof. The external preparation for skin is a component usually used in external preparations for skin such as pharmaceuticals, for example, water-based ingredients, oil-based ingredients, powder ingredients, alcohols, moisturizers, thickeners, UV absorbers, whitening agents, preservatives, antioxidants, surfactants, fragrances, colorants , various skin nutrients, or a combination thereof may be appropriately formulated as needed. The external preparation for skin includes metal-blocking agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, and gluconic acid, caffeine, tannin, belapamil, licorice extract, glablidine, and kaline. Fruit hot water extract, various herbal medicines, drugs such as tocopherol acetate, glitylic acid, tranexamic acid and its derivatives or salts, vitamin C, magnesium ascorbate phosphate, glucoside ascorbate, arbutin, kojic acid, glucose, fructose, Sugars, such as trehalose, etc. can be mix|blended suitably.

As described above, the composition according to an aspect does not substantially contain a water-soluble acrylic organic thickener, and although it contains only two or more surfactants having different molecular weights, a Pickering liquid crystal can be formed on the surface of the emulsion droplet. there is. Therefore, it not only exhibits a feeling of use corresponding to the spreadability of oil-in-water cosmetics, but also has low viscosity and excellent formulation stability.

Another aspect provides a method for preparing a composition of an emulsion formulation wherein the crystal structure is a lamellar structure. The method comprises the steps of mixing two or more surfactants having different molecular weights and dissolving them by heating at a temperature of 75 to 95° C. to prepare an oil phase; and stirring the oil phase to the aqueous phase containing the polyol to prepare a mixed solution of the oil phase and the aqueous phase.

The composition according to an aspect contains two or more polyglycerin-based surfactants having different molecular weights, thereby making the droplet size of the emulsion small and uniform, as well as forming a more solid liquid crystal on the surface of the droplet, resulting in excellent formulation stability. In addition, it is light and non-sticky when applied to the skin due to its low viscosity, and has an effect corresponding to the feeling of use of oil-in-water (O/W) cosmetics.

1 is an external image of Examples 1 to 3 and Comparative Examples 1 to 3 after performing the F/T stability test 5 times.
2 is an optical microscope image (left) and a polarization microscope image (right) taken immediately after preparation of Example 3.
3 is an optical microscope image (left) and a polarization microscope image (right) taken after storing Example 3 at a high temperature for 1 month.
4 is a result confirming the presence of a lamellar peak in a water-in-oil type low-viscosity liquid crystal emulsion through small angle X-ray scattering.
5 is an optical microscope image (left) and a polarization microscope image (right) taken after storing Comparative Example 4 at a high temperature for 1 month.
6 is an optical microscope image (left) and a polarization microscope image (right) taken after storing Comparative Example 6 at a high temperature for 1 month.

Hereinafter, the present invention will be described in detail.

Hereinafter, preferred examples are presented to help the understanding of the present invention. However, the following examples are only provided for easier understanding of the present invention, and the contents of the present invention are not limited by the following examples.

[Example]

Examples 1 to 6. Preparation of water-in-oil type low-viscosity liquid crystal emulsion cosmetic composition

A water-in-oil type low-viscosity liquid crystal emulsion cosmetic composition was prepared by performing the following method. First, surfactant, hydrocarbon oil, vegetable oil, and suspending agent among the oily components of A were measured and then uniformly dispersed at 80° C. with an agi-mixer for 10 minutes. Then, the aqueous phase component of B was weighed and the purified water heated to 80° C. and the remaining components were evenly stirred. While slowly adding the aqueous phase component of B to A, the mixture was stirred at 500 rpm for 10 minutes with a disper mixer. Then, it was emulsified at 7000 rpm for 3 minutes. After emulsification, when the temperature of the emulsion solution was 40° C., purified water was added to correct water, and a preservative was added, followed by emulsification at 7000 rpm for 1 minute. Table 1 below shows specific components and contents of the cosmetic composition prepared according to the above method. Unless otherwise stated herein, component content is in weight percent.

ingredient content (wt%) Example 1 Example 2 Example 3 Example 4 Example 5 A: paid interface
activator Polyglyceryl-2 isostearate 2.4 2.1 1.8 - - Polyglyceryl-6 polyricinoleate 0.5 0.5 0.5 - - Polyglyceryl-4 isostearate - - - 1.8 Polyglyceryl-2 Diisostearate - - - - 1.8 Polyglyceryl-6 polyricinoleate - - - 0.5 - Polyglyceryl-6 polyhydroxystearate - - - - 0.5 hydrocarbon oil squalane 10 10 10 10 10 isododecane 9.6 9.6 9.6 9.6 9.6 suspending agent Disteadimonium Hectorite 1.4 1.4 1.4 1.4 1.4 vegetable oil jojoba oil 4 4 4 4 4 sunflower seed oil 4 4 4 4 4 B: Award menstruum Purified water 50.75 51.05 51.35 51.35 51.35 moisturizer diglycerin 3 3 3 3 3 glycerin 5 5 5 5 5 1,3-butylene glycol 8 8 8 8 8 bulking agent magnesium sulfate 0.8 0.8 0.8 0.8 0.8 antiseptic Ethylhexylglycerin 0.15 0.15 0.15 0.15 0.15 caprylyl glycol 0.4 0.4 0.4 0.4 0.4 total amount 100 100 100 100 100

Comparative Examples 1 to 7. Preparation of water-in-oil type low-viscosity liquid crystal emulsion cosmetic composition

A water-in-oil type low-viscosity liquid crystal emulsion cosmetic composition was prepared in the same manner as in the above Example, except that the components and contents of Table 2 were used.

ingredient content (% by weight) Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 A: paid interface
activator Polyglyceryl-2 isostearate 1.8 One 3 - - - - Polyglyceryl-6 polyricinoleate 0.6 0.6 0.6 - - - - Polyglyceryl-4 isostearate - - - - - 2.5 - Polyglyceryl-2 Diisostearate - - - - - - 2.5 Polyglyceryl-6 polyricinoleate - - - 2.5 - - - Polyglyceryl-6 polyhydroxystearate - - - - 2.5 - - hydrocarbon oil squalane 10 10 10 10 10 10 10 isododecane 9.6 9.6 9.6 9.6 9.6 9.6 9.6 suspending agent Disteadimonium
hectorite 1.4 1.4 1.4 1.4 1.4 1.4 1.4 vegetable oil jojoba oil 4 4 4 4 4 4 4 sunflower seed oil 4 4 4 4 4 4 4 B: Award menstruum Purified water 67.25 51.35 50.05 51.15 67.15 51.15 51.15 moisturizer diglycerin 0 3 3 3 0 3 3 glycerin 0 5 5 5 0 5 5 1,3 Butylene Glycol 0 8 8 8 0 8 8 bulking agent magnesium sulfate 0.8 0.8 0.8 0.8 0.8 0.8 0.8 antiseptic Ethylhexylglycerin 0.15 0.15 0.15 0.15 0.15 0.15 0.15 caprylyl glycol 0.4 0.4 0.4 0.4 0.4 0.4 0.4 total amount 100 100 100 100 100 100 100

[Experimental example]

Experimental Example 1. Evaluation of freeze-thaw stability

Since the water-in-oil type emulsion has an aqueous phase, a low-temperature stability test is absolutely necessary. Therefore, the temperature stability test for each glycerin content of Examples 1 to 3 and Comparative Examples 1 to 3 was performed. Specifically, a freeze-thaw (hereinafter, F/T) test, which is a more extreme environmental condition than low-temperature stability, was conducted, and the temperature was alternately stored at -20°C and 50°C for 24 hours, respectively. In case of storage at -20℃ for 12 hours and at 50℃ for 12 hours, it is marked as F/T once. After a total of 5 F/T cycles, changes over time were observed.

1 is an external image of Examples 1 to 3 and Comparative Examples 1 to 3 after performing the F/T stability test 5 times.

As shown in FIG. 1 , a phase separation phenomenon occurred in Comparative Examples 1 to 3 as compared to Examples 1 to 3. In particular, in Comparative Example 1, it was confirmed that the phase separation phenomenon appeared clearly.

That is, it can be seen that the polyol is effective in preventing phase separation due to the freezing point lowering effect as well as moisturizing.

Experimental Example 2. Long-term stability evaluation

2-1. Long-term stability as a function of viscosity

The long-term stability according to the viscosity of the cosmetic compositions of Examples and Comparative Examples was confirmed. Specifically, the viscosity of Examples 1 to 3 and Comparative Examples 1 to 3 was measured for 1 minute at 30 rpm by mounting an LV 64 spindle with a Brookfield DV2TLV. The results are shown in Table 3 below.

Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Viscosity (cPs) 6,800 5,100 4,700 4,300 1,500 12,500

As shown in Table 3, the viscosity of Examples 1 to 3 and Comparative Examples 1 to 3 increased in proportion to the amount of the surfactant. However, long-term stability was not ensured because of the high viscosity. Specifically, as in Comparative Example 3, when the concentration of the surfactant was above a certain amount, phase separation occurred. This is thought to be because the two surfactants did not properly adsorb to the surface of the emulsion droplet. In addition, in the case of Comparative Example 3 in which the surfactant was included in excess, the viscosity was significantly increased compared to Examples 1 to 3, and the stiff feeling of use, which was a chronic disadvantage of the water-in-oil emulsion, was also shown.

2-2. Long-term stability with temperature

Long-term stability according to the temperature of Examples 1 to 3 and Comparative Examples 1 to 3 was confirmed. Specifically, it was checked whether the cosmetic compositions of Examples and Comparative Examples were phase separated by storage at low temperature (-20°C) and high temperature (50°C) for 1 week, 2 weeks, and 1 month, respectively. In addition, they were stored alternately for 24 hours each at a low temperature and a high temperature, and one repetition was denoted as 1 cycle (1C) and performed for 5 cycles. The results are shown in Table 4 below.

Condition observation period Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Cycle
(-20℃↔50℃) 1C ◎ ◎ ◎ ○ ○ ◎ 2C ◎ ◎ ◎ X ○ ○ 3C ◎ ◎ ◎ X △ △ 4C ◎ ◎ ○ X △ △ 5C ◎ ○ ○ X △ △ Low temperature (-20℃) 1 week ◎ ◎ ◎ △ △ ○ 2 weeks ◎ ◎ ○ X △ △ 1 month ◎ ○ ○ X △ △ high temperature (50℃) 1 week ◎ ◎ ◎ △ △ ○ 2 weeks ◎ ◎ ◎ X △ △ 1 month ◎ ○ ○ X △ △

◎: very stable / ○: stable / △: unstable / X: phase separation

As shown in Table 4, in the case of Examples 1 to 3, it was confirmed that the formulation was stable because almost no phase separation occurred even after 1 month in low and high temperature conditions and cycle conditions. In particular, after 1 month at high temperature, the viscosity slightly decreased and the size of the emulsion droplets increased, but they were stable in appearance. On the other hand, Comparative Example 2 and Comparative Example 3 containing an excessive amount of surfactant were unstable over time at low and high temperatures, and were particularly vulnerable at low temperatures. On the other hand, in Comparative Example 1 in which the amount of surfactant was similar to that of Example 3, phase separation occurred under low and high temperature conditions and cycle conditions, and the formulation was unstable. This is considered to be because the polyol effective for preventing phase separation due to the freezing point lowering effect is not included in the composition.

Experimental Example 3. Small-angle x-ray scattering (SAXS) analysis

A macroscopic structure such as a lamellar structure was confirmed by performing small-angle X-ray scattering analysis on the liquid crystal emulsion immediately after the preparation of the liquid crystal emulsion of Example 3 and after F/T 5 times. It was conducted at room temperature using a light source with an energy of 3 GeV, and the light coming from In-Vacuum Undulator 20 (IVU20, length: 1 m, period: 20 mm) of the PLS ± storage ring was collected on a mirror coated with rhodium. It is monochromatized by a Si (111) Double Crystal Monochromator (DCM) to produce a beam with a wavelength of 0.734 Å ^-1 . The distance between the sample and the detector was 4 m, and the scattering vector (q = ) was set to 0.3 nm ^-1 < q < 6.85 nm ^-1 . 2e is a scattering angle, λ is an X-ray wavelength value, and the scattering angle was calibrated with silver behenate, and each sample was leveled in a semicircular direction, loaded between polyamide films, and measured for about 30 seconds.

4 is a small-angle X-ray scattering graph immediately after the preparation of Example 3 and after performing F/T 5 times.

As shown in FIG. 4 , the liquid crystal emulsion of Example 3 had a q value (x-axis value) of 0.127 Å ⁻¹ , 0.254 Å ⁻¹ , 0.381 Å ⁻¹ immediately after preparation in a 1:2:3 ratio. According to the Bragg spacing ratio, when the ratio of the small-angle X-ray scattering peak is 1: 2: 3, it can be seen that the water-in-oil type low-viscosity liquid crystal emulsion prepared in Example 3 has a lamellar structure because it has a lamellar structure. In addition, by substituting the first peak value of q1 into the formula d = 2π/q, the interlayer distance of the lamella can be obtained. . After F/T 5 times, the q value of the emulsion was 0.126 Å ^-1 , 0.252 Å ^-1 , 0.378 Å ^-1 , which had the same 1: 2: 3 ratio as immediately after preparation, and had an interlayer distance of 4.984 nm. appear. Through this, it was proved that the water-in-oil type low-viscosity liquid crystal emulsion prepared with two or more polyglycerin-based surfactants maintains the lamellar structure even under extreme conditions. That is, the composition according to an aspect has a lamellar structure forming a structure similar to the skin barrier, so that the active ingredient can be more easily adsorbed to the skin when applied to the skin, and there is an advantage in that there is little irritation to the skin. Therefore, it is excellent in moisturizing the skin and strengthens the weakened skin barrier to protect moisture in the skin and protects the skin from external stimuli, thereby improving the skin condition.

Experimental Example 4. Formulation stability evaluation

In order to experimentally prove that the stability of the water-in-oil-type emulsion is maintained by the liquid crystal formed by the polyglyceryl-based surfactant, the above Experimental Example 2 was tested in the same way as

5 is an optical microscope image (left) and a polarization microscope image (right) taken after storing Comparative Example 4 at a high temperature for 1 month.

As shown in FIG. 5 , Examples 4 to 5 showed excellent stability results under the conditions of F/T 5 times and high temperature (50° C.) for 1 month. On the other hand, as shown in FIG. 5 , in Comparative Examples 4 to 5 using only a high molecular weight polyglyceryl-based surfactant, high viscosity was maintained. In addition, it was confirmed that the liquid crystal emulsion was relatively large and faint as the average size of the droplets was 5 μm. However, it was confirmed that the phase was separated within a few days and the stability was not good.

6 is an optical microscope image (left) and a polarization microscope image (right) taken after storing Comparative Example 6 at a high temperature for 1 month.

As shown in FIG. 6 , in Comparative Examples 6 to 7 in which only low molecular weight polyglyceryl surfactants were used, low viscosity was maintained and the average droplet size was 1 μm, which was relatively small and uniform. However, the shape of the liquid crystal could not be seen, and the stability was very unstable as the phases were separated on the first F/T and on the 3rd day of high temperature.

The above results mean that a stable emulsion composition can be implemented while forming a liquid crystal and having a sufficiently small emulsion droplet size when a polymer type and a low molecular type surfactant must be mixed among polyglyceryl-based surfactants.

Therefore, the cosmetic composition according to an aspect contains a high molecular weight polyglyceryl surfactant and a low molecular weight polyglyceryl surfactant, so that it is possible to prepare stable emulsion droplets with low viscosity and small and uniform liquid crystal formation. there is.

The description of the present invention described above is for illustration, and those of ordinary skill in the art to which the present invention pertains can understand that it can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive.

Claims (9)

an oil phase containing a low molecular weight polyglycerin-based surfactant and a high molecular weight polyglycerin-based surfactant; A cosmetic composition of an emulsion formulation comprising an aqueous phase containing polyol and having a lamellar crystal structure. The method according to claim 1, wherein the low molecular weight polyglycerin-based surfactant is polyglyceryl-4 isostearate, polyglyceryl-2 diisostearate, polyglyceryl-2 isostearate, polyglyceryl-5 hexa A cosmetic composition comprising at least one selected from the group consisting of stearate, polyglyceryl-10 heptaoleate, polyglyceryl-10 pentastearate, and polyglyceryl-10 decasterate. The method according to claim 1, wherein the high molecular weight polyglycerin-based surfactant is polyglyceryl-6 polyhydroxystearate, polyglyceryl-10 polyhydroxystearate, polyglyceryl-3 polyricinoleate, polyglyceryl Reel-4 polyricinoleate, polyglyceryl-5 polyricinoleate, polyglyceryl-6 polyricinoleate, and polyglyceryl-10 polyricinoleate, any one or more cosmetic composition selected from the group consisting of. The cosmetic composition according to claim 1, wherein the low molecular weight and high molecular weight polyglycerin-based surfactant is mixed in a weight ratio of 1:10 to 10:1. The cosmetic composition according to claim 1, wherein the surfactant is contained in an amount of 0.5 to 3.5% by weight based on the total weight of the composition. The cosmetic composition of claim 1, wherein the polyol is at least one selected from the group consisting of diglycerin, glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, methylpropanediol, and sorbitol. The cosmetic composition according to claim 1, wherein the composition has a viscosity of 2,000 cPs to 8,000 cPs. The cosmetic composition of claim 1, wherein the composition forms liquid crystals (LCs) on the surface of the emulsion droplet. an oil phase containing a low molecular weight polyglycerin-based surfactant and a high molecular weight polyglycerin-based surfactant; An emulsion type skin external agent composition comprising an aqueous phase containing polyol and having a lamellar crystal structure.

Images