KR20220042055A - 골수성 세포 염증성 표현형을 조절하기 위한 항-psgl-1 조성물 및 방법, 그리고 이의 용도 - Google Patents

골수성 세포 염증성 표현형을 조절하기 위한 항-psgl-1 조성물 및 방법, 그리고 이의 용도 Download PDF

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KR20220042055A
KR20220042055A KR1020217040138A KR20217040138A KR20220042055A KR 20220042055 A KR20220042055 A KR 20220042055A KR 1020217040138 A KR1020217040138 A KR 1020217040138A KR 20217040138 A KR20217040138 A KR 20217040138A KR 20220042055 A KR20220042055 A KR 20220042055A
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cells
macrophages
agent
cell
myeloid cells
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Korean (ko)
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타티아나 아이. 노보브란트세바
이고르 펠드만
스티븐 엘. 사진스키
조셉 에이. 와일
브라이언 오누알랭
라이언 페니시
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베르조 테라퓨틱스, 아이엔씨.
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KR1020217040138A 2019-06-04 2020-06-02 골수성 세포 염증성 표현형을 조절하기 위한 항-psgl-1 조성물 및 방법, 그리고 이의 용도 Pending KR20220042055A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962857169P 2019-06-04 2019-06-04
US62/857,169 2019-06-04
US201962867569P 2019-06-27 2019-06-27
US62/867,569 2019-06-27
US201962947948P 2019-12-13 2019-12-13
US62/947,948 2019-12-13
US202063032214P 2020-05-29 2020-05-29
US63/032,214 2020-05-29
PCT/US2020/035702 WO2020247371A1 (en) 2019-06-04 2020-06-02 Anti-psgl-1 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof

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EP (1) EP3980463A4 (https=)
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KR (1) KR20220042055A (https=)
CN (1) CN114401990A (https=)
AU (1) AU2020288823A1 (https=)
BR (1) BR112021024242A2 (https=)
CA (1) CA3141334A1 (https=)
IL (1) IL288510A (https=)
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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
CA3141334A1 (en) 2019-06-04 2020-12-10 Verseau Therapeutics, Inc. Anti-psgl-1 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof
GB2584664B (en) * 2019-06-10 2023-05-24 Newcells Biotech Ltd Improved retinal organoids and methods of making the same
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
US20220284243A1 (en) * 2021-03-03 2022-09-08 International Business Machines Corporation Ensemble voting classifiers using adjusted thresholds
WO2023091958A1 (en) * 2021-11-17 2023-05-25 Altrubio Inc. Methods of using anti-psgl-1 antibodies in combination with jak inhibitors to treat t-cell mediated inflammatory diseases or cancers
CN116380755B (zh) * 2023-03-20 2023-11-21 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） CD127+PMN-MDSCs在诊断支气管肺发育不良中的应用及诊断试剂盒
CN120682308B (zh) * 2025-06-23 2025-12-02 北京昌盛鸿途生物科技有限公司 牛骨髓肽及其在提高免疫力中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852497B2 (en) 2000-03-24 2005-02-08 Genetics Institute, Llc Methods of identifying compounds which inhibit binding of SLIC-1 to PSGL-1
US7744888B2 (en) * 2001-08-03 2010-06-29 Abgenomics Cooperatief U.A. Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies
CN1897970A (zh) * 2003-06-30 2007-01-17 生物技术通用（以色列）有限公司 特异人抗体
CN1972703A (zh) 2004-03-30 2007-05-30 丹麦皇家兽医和农业学院 通过阻断和检测蛋白酶抑制剂改进癌症的治疗和癌症治疗效率的预测
MY148646A (en) 2004-05-10 2013-05-15 Abgenomics Cooperatief Ua Anti-psgl-1 antibodies
WO2007033959A2 (en) 2005-09-19 2007-03-29 Vib Vzw Use of p-selectin glycoprotein ligand 1 in modulation of hematogenous metastasis of lymphomas
US20110212096A1 (en) 2006-12-01 2011-09-01 Scott Rollins Anti-p-selectin antibodies and methods of their use and identification
WO2009140623A2 (en) 2008-05-15 2009-11-19 Selexys Pharmaceuticals Corporation Anti-psgl-1 antibodies and methods of identification and use
WO2011143411A1 (en) 2010-05-12 2011-11-17 Abt Holding Company Modulation of splenocytes in cell therapy for traumatic brain injury
US20120130603A1 (en) 2010-11-18 2012-05-24 Sean Michael Simpson System and method for controlling a transmission of a human-powered vehicle
WO2012088265A1 (en) * 2010-12-21 2012-06-28 Selexys Pharmaceuticals Corporation Anti-p-selectin antibodies and methods of their use and identification
MX358447B (es) * 2011-06-13 2018-08-21 Abgenomics Cooeperatief U A Star Anticuerpos anti-psgl-1 y usos de los mismos.
US9139652B2 (en) 2011-10-21 2015-09-22 Transgene Sa Method for increasing M1 macrophages in a patient
WO2015077401A1 (en) 2013-11-20 2015-05-28 Drexel University Compositions and methods for macrophage conversion
PT3166636T (pt) 2014-07-08 2021-06-29 Sanford Burnham Med Res Inst Moduladores de psgl-1 e utilizações dos mesmos
US20170306042A1 (en) 2014-08-29 2017-10-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Immunogenic modulation by endocrine deprivation therapy improves sensitivity of tumor cells to immune mediated lysis
US20160200815A1 (en) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
CN109789201B (zh) * 2016-04-15 2023-06-16 伊穆奈克斯特股份有限公司 抗人vista抗体及其用途
GB201611535D0 (en) 2016-07-01 2016-08-17 King S College London Methods and compositions for treating cancer with siglec-9 activity modulators
EP3568159A4 (en) 2017-01-11 2020-08-05 Bristol-Myers Squibb Company PSGL-1 ANTAGONISTS AND THEIR USES
JP2021529753A (ja) 2018-06-29 2021-11-04 ヴェルソー セラピューティクス， インコーポレイテッド 単球及びマクロファージの炎症性表現型を調節するための組成物及び方法、ならびにそれを使用する免疫療法
CA3141334A1 (en) 2019-06-04 2020-12-10 Verseau Therapeutics, Inc. Anti-psgl-1 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof

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EP3980463A4 (en) 2023-06-28
US20220396632A1 (en) 2022-12-15
CN114401990A (zh) 2022-04-26
JP7716992B2 (ja) 2025-08-01
IL288510A (en) 2022-01-01
US12552873B2 (en) 2026-02-17
JP2025129213A (ja) 2025-09-04
TW202110891A (zh) 2021-03-16
EP3980463A1 (en) 2022-04-13
AU2020288823A1 (en) 2022-02-03
CA3141334A1 (en) 2020-12-10
WO2020247371A8 (en) 2021-12-02
WO2020247371A1 (en) 2020-12-10
JP2022535550A (ja) 2022-08-09

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