KR20220013570A - 생체분자 전달을 위한 다중 관능화된 곁사슬을 포함하는 폴리머 - Google Patents

생체분자 전달을 위한 다중 관능화된 곁사슬을 포함하는 폴리머 Download PDF

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KR20220013570A
KR20220013570A KR1020217042746A KR20217042746A KR20220013570A KR 20220013570 A KR20220013570 A KR 20220013570A KR 1020217042746 A KR1020217042746 A KR 1020217042746A KR 20217042746 A KR20217042746 A KR 20217042746A KR 20220013570 A KR20220013570 A KR 20220013570A
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group
polymer
formula
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이근우
산타누 마이티
프랑코 두아르테
밍치 탄
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진에딧 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/04—Polyamides derived from alpha-amino carboxylic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020217042746A 2019-05-28 2020-05-28 생체분자 전달을 위한 다중 관능화된 곁사슬을 포함하는 폴리머 Ceased KR20220013570A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962853658P 2019-05-28 2019-05-28
US62/853,658 2019-05-28
US201962907458P 2019-09-27 2019-09-27
US62/907,458 2019-09-27
PCT/US2020/035007 WO2020243370A1 (en) 2019-05-28 2020-05-28 Polymer comprising multiple functionalized sidechains for biomolecule delivery

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KR20220013570A true KR20220013570A (ko) 2022-02-04

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KR1020217042746A Ceased KR20220013570A (ko) 2019-05-28 2020-05-28 생체분자 전달을 위한 다중 관능화된 곁사슬을 포함하는 폴리머

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US (1) US20220340712A1 (enExample)
EP (1) EP3976015A1 (enExample)
JP (1) JP7805789B2 (enExample)
KR (1) KR20220013570A (enExample)
AU (1) AU2020282798A1 (enExample)
CA (1) CA3142035A1 (enExample)
WO (1) WO2020243370A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024020332A1 (en) * 2022-07-18 2024-01-25 Bridgeway Innovations, Llc Oxidatively degrading and ros scavenging polymers for medical applications

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JP7568511B2 (ja) 2018-04-27 2024-10-16 ジーンエディット インコーポレイテッド カチオン性ポリマーおよびその生体分子送達のための使用
JP2022502384A (ja) 2018-09-25 2022-01-11 国立大学法人 東京大学 両親媒性ポリアミノ酸、該両親媒性ポリアミノ酸を用いたブロックコポリマー、および該両親媒性ポリアミノ酸または該ブロックコポリマーと核酸とを含む複合体
EP4352131A1 (en) 2021-06-11 2024-04-17 Genedit Inc. Biodegradable polymer comprising side chains with polyamine and polyalkylene oxide groups

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GB9811059D0 (en) * 1998-05-23 1998-07-22 Univ Strathclyde Polyamino acid vesicles
IL131074A0 (en) * 1999-07-23 2001-03-19 Polygene Ltd A biodegradable polycation composition for delivery of an anionic macromolecule
WO2010075303A1 (en) 2008-12-23 2010-07-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Splicing factors with a puf protein rna-binding domain and a splicing effector domain and uses of same
WO2010093036A1 (ja) * 2009-02-13 2010-08-19 国立大学法人東京大学 カチオン性のポリ（アミノ酸）およびその使用
EP2462938B1 (en) * 2009-07-23 2018-08-29 The University of Tokyo Anionic polymer, polyion complex and ternary polymer composite using anionic polymer, and pharmaceutical composition
JP4655298B1 (ja) * 2010-02-23 2011-03-23 ナノキャリア株式会社 短鎖のカチオン性ポリアミノ酸およびその使用
US9580714B2 (en) 2010-11-24 2017-02-28 The University Of Western Australia Peptides for the specific binding of RNA targets
US20120237565A1 (en) * 2011-03-14 2012-09-20 Intezyne Technologies, Incorporated Pegylated polyplexes containing two or more different polymers for polynucleotide delivery
CA2873073A1 (en) 2012-04-16 2013-10-24 The University Of Western Australia Peptides for the binding of nucleotide targets
US20140310830A1 (en) 2012-12-12 2014-10-16 Feng Zhang CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
ES2576126T3 (es) 2012-12-12 2016-07-05 The Broad Institute, Inc. Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
CN114634950A (zh) 2012-12-12 2022-06-17 布罗德研究所有限公司 用于序列操纵的crispr-cas组分系统、方法以及组合物
EP2931898B1 (en) 2012-12-12 2016-03-09 The Broad Institute, Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
JP2016504026A (ja) 2012-12-12 2016-02-12 ザ・ブロード・インスティテュート・インコーポレイテッド 配列操作のための系、方法および最適化ガイド組成物のエンジニアリング
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US20180237800A1 (en) * 2015-09-21 2018-08-23 The Regents Of The University Of California Compositions and methods for target nucleic acid modification
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EP3541945A4 (en) * 2016-11-18 2020-12-09 Genedit Inc. COMPOSITIONS AND METHODS OF MODIFICATION OF TARGET NUCLEIC ACIDS
WO2021217082A1 (en) * 2020-04-23 2021-10-28 Genedit Inc. Polymer with cationic and hydrophobic side chains

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024020332A1 (en) * 2022-07-18 2024-01-25 Bridgeway Innovations, Llc Oxidatively degrading and ros scavenging polymers for medical applications

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US20220340712A1 (en) 2022-10-27
AU2020282798A1 (en) 2021-12-16
CA3142035A1 (en) 2020-12-03
EP3976015A1 (en) 2022-04-06
WO2020243370A1 (en) 2020-12-03
JP7805789B2 (ja) 2026-01-26
JP2022534245A (ja) 2022-07-28

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