KR20210150402A - 분석물 검출 및 분석을 위한 방법, 장치, 및 시스템 - Google Patents

분석물 검출 및 분석을 위한 방법, 장치, 및 시스템 Download PDF

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Publication number
KR20210150402A
KR20210150402A KR1020217032353A KR20217032353A KR20210150402A KR 20210150402 A KR20210150402 A KR 20210150402A KR 1020217032353 A KR1020217032353 A KR 1020217032353A KR 20217032353 A KR20217032353 A KR 20217032353A KR 20210150402 A KR20210150402 A KR 20210150402A
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KR
South Korea
Prior art keywords
nucleic acid
substrate
acid molecules
axis
rotation
Prior art date
Application number
KR1020217032353A
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English (en)
Korean (ko)
Inventor
나단 베케트
길라드 알모지
나단 카스웰
제이콥 에이 볼프
크리스토퍼 바비
데니스 프리스틴스키
마크 프랫
진 폴로비
오십 슈바르츠
스테파니 쿠베카
스티븐 멘첸
조셉 안토니
조세 마틴 소사
필립 유 파이 리
Original Assignee
울티마 제노믹스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/445,798 external-priority patent/US10900078B2/en
Priority claimed from US16/677,067 external-priority patent/US10830703B1/en
Priority claimed from US16/677,115 external-priority patent/US10852518B1/en
Application filed by 울티마 제노믹스, 인크. filed Critical 울티마 제노믹스, 인크.
Publication of KR20210150402A publication Critical patent/KR20210150402A/ko

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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
    • B01J4/007—Feed or outlet devices as such, e.g. feeding tubes provided with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/10—Scanning
    • G01N2201/104—Mechano-optical scan, i.e. object and beam moving

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Microscoopes, Condenser (AREA)
  • Spectroscopy & Molecular Physics (AREA)
KR1020217032353A 2019-03-14 2020-03-13 분석물 검출 및 분석을 위한 방법, 장치, 및 시스템 KR20210150402A (ko)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201962818549P 2019-03-14 2019-03-14
US62/818,549 2019-03-14
US201962837684P 2019-04-23 2019-04-23
US62/837,684 2019-04-23
US16/445,798 2019-06-19
US16/445,798 US10900078B2 (en) 2019-03-14 2019-06-19 Methods, devices, and systems for analyte detection and analysis
US201962914293P 2019-10-11 2019-10-11
US62/914,293 2019-10-11
US16/677,067 US10830703B1 (en) 2019-03-14 2019-11-07 Methods, devices, and systems for analyte detection and analysis
US16/677,115 US10852518B1 (en) 2019-03-14 2019-11-07 Methods, devices, and systems for analyte detection and analysis
US16/677,115 2019-11-07
US16/677,067 2019-11-07
PCT/US2020/022816 WO2020186243A1 (en) 2019-03-14 2020-03-13 Methods, devices, and systems for analyte detection and analysis

Publications (1)

Publication Number Publication Date
KR20210150402A true KR20210150402A (ko) 2021-12-10

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KR1020217032353A KR20210150402A (ko) 2019-03-14 2020-03-13 분석물 검출 및 분석을 위한 방법, 장치, 및 시스템

Country Status (9)

Country Link
EP (1) EP3938832A4 (zh)
JP (1) JP7530909B2 (zh)
KR (1) KR20210150402A (zh)
CN (1) CN113841078B (zh)
AU (2) AU2020239263B2 (zh)
CA (2) CA3238741A1 (zh)
MX (1) MX2021010896A (zh)
SG (1) SG11202109764VA (zh)
WO (1) WO2020186243A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023113120A1 (ko) * 2021-12-16 2023-06-22 (주)레보스케치 회전형 다채널 형광스캐너

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US10344328B2 (en) 2017-11-17 2019-07-09 Ultima Genomics, Inc. Methods for biological sample processing and analysis
US11499962B2 (en) 2017-11-17 2022-11-15 Ultima Genomics, Inc. Methods and systems for analyte detection and analysis
US10512911B1 (en) 2018-12-07 2019-12-24 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US11118223B2 (en) 2019-03-14 2021-09-14 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US10900078B2 (en) 2019-03-14 2021-01-26 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US20220403466A1 (en) * 2021-06-17 2022-12-22 Mgi Tech Co., Ltd. Sequencing systems and methods utilizing curved imaging paths on rotating substrates
CN115041157B (zh) * 2022-06-10 2023-08-08 佛山科学技术学院 一种制氢催化剂载体及其制备方法
KR102704324B1 (ko) * 2022-11-16 2024-09-09 한국수자원공사 소형생물 모니터링 장치 및 이의 모니터링 방법
WO2024130655A1 (zh) * 2022-12-22 2024-06-27 深圳华大生命科学研究院 试剂传输方法及用于基因测序的表面液路系统
CN116930481A (zh) * 2023-09-12 2023-10-24 重庆医科大学绍兴柯桥医学检验技术研究中心 一种磁场驱动微纳米马达的跨分子检测方法

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US4962020A (en) 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5800997A (en) * 1996-11-01 1998-09-01 Novartis Finance Corporation Detection of maize fungal pathogens using the polymerase chain reaction
US6320609B1 (en) * 1998-07-10 2001-11-20 Nanometrics Incorporated System using a polar coordinate stage and continuous image rotation to compensate for stage rotation
US20020055112A1 (en) * 2000-08-26 2002-05-09 Nila Patil Methods for reducing complexity of nucleic acid samples
EP1345026B1 (en) * 2002-03-15 2010-05-05 Affymetrix, Inc. System and method for scanning of biological materials
US20030224506A1 (en) 2002-05-30 2003-12-04 Biomicroarrays Inc Tiled biochips and the methods of making the same
US9976192B2 (en) * 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
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CN101893523A (zh) * 2009-05-20 2010-11-24 纳米基因有限公司 分析物检测的方法和组合物
KR101567195B1 (ko) * 2013-03-14 2015-11-06 가부시키가이샤 스크린 홀딩스 토출 검사 장치 및 기판 처리 장치
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023113120A1 (ko) * 2021-12-16 2023-06-22 (주)레보스케치 회전형 다채널 형광스캐너

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SG11202109764VA (en) 2021-10-28
MX2021010896A (es) 2023-03-16
AU2020239263B2 (en) 2024-05-02
JP7530909B2 (ja) 2024-08-08
AU2020239263A1 (en) 2021-10-07
CA3129726A1 (en) 2020-09-17
CN113841078B (zh) 2024-10-01
WO2020186243A1 (en) 2020-09-17
EP3938832A4 (en) 2023-03-22
JP2022526715A (ja) 2022-05-26
AU2024205158B2 (en) 2024-08-22
AU2024205158A1 (en) 2024-08-15
EP3938832A1 (en) 2022-01-19
CA3238741A1 (en) 2020-09-17
CN113841078A (zh) 2021-12-24

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