KR20210136645A - Vibration device installed in the ventricle - Google Patents

Abstract

A vibration device is provided. The vibration device includes at least one of a first vibrator installed in at least one of soft membrane, subarachnoid space, arachnoid membrane, dura mater, skull bone, and head skin, and a second vibrator installed in the ventricle. The first vibrator can generate the first energy for vibrating the cerebrospinal fluid flowing through the subarachnoid space. The second vibrator can generate the second energy for vibrating the cerebrospinal fluid flowing through the ventricle.

Description

Vibration device installed in the ventricle

The present invention relates to a vibration device installed directly in the ventricle.

Due to the increase in human life expectancy, the elderly population is rapidly increasing, and the number of dementia patients is continuously increasing accordingly. Alzheimer's disease is a major cause of dementia and is a type of degenerative brain disease in which β-amyloid protein accumulates and induces cytotoxicity, thereby degenerating nerve cells and losing cognitive ability.

Although the cause of Alzheimer's disease has not yet been fully elucidated, associations of beta-amyloid protein, tau protein, and ApoE protein have been reported. In the beta amyloid protein, amyloid beta precursor protein (APP) in the brain is cleaved by beta-secretase and gamma-secretase to form senile plaques. In addition, when beta-amyloid accumulates in the brain, it causes denaturation and accumulation of tau protein, thereby forming a neurofibrillary tangle. Old age spots and nerve fiber bundles are characteristic lesions of Alzheimer's disease.

When observing Alzheimer's disease with the naked eye, general brain atrophy is seen due to the loss of nerve cells. In the early stages of the disease, brain atrophy is limited to the hippocampus and entorhinal cortex, which are the brain regions mainly responsible for memory. It can be seen that it spreads throughout the brain. As a treatment for Alzheimer's disease, acetylcholinesterase inhibitors such as donepezil, galantamine, and rivastigmine, and NMDA receptor antagonists such as memantine are commercially available, but do not fundamentally eliminate aggregation of amyloid beta and/or tau protein. There are limitations that cannot be achieved, and alternative treatments are strongly required.

On the other hand, hydrocephalus is a disease in which cerebrospinal fluid accumulates abnormally in the brain. Hydrocephalus causes high fever due to excessive production of cerebrospinal fluid, viral and bacterial infections, and can cause aqueduct stenosis, ventricular outlet stenosis, subarachnoid cyst, brain tumor, cerebral hemorrhage, tissue malformation due to cerebrospinal fluid flow disturbance, and absorption of cerebrospinal fluid. It can cause cerebral hemorrhage due to the disorder and inflammation of the arachnoid villi. The increase in intracranial pressure in the skull due to hydrocephalus can lead to gradual enlargement of the head at a young age, which can cause convulsions, tunnel vision, and mental disorders. Hydrocephalus is a disease that occurs with a certain probability not only in humans but also in companion animals such as dogs and cats.

Cerebrospinal fluid (CSF) is a colorless and transparent fluid that circulates along the ventricles and spinal cord, and is produced approximately 500 mL per day, and is maintained at an average of 100-150 mL in the ventricles and subarachnoid space. The cerebrospinal fluid reduces the weight of the brain and spinal cord, protects the brain from external shocks, and buffers the sudden disease of temperature, and plays a role in transporting hormones and wastes.

A method for improving local stagnation of cerebrospinal fluid for preventing or treating brain diseases such as Alzheimer's disease is partially disclosed in Korean Patent Application Laid-Open No. 10-2010-0126425. However, the prior art is to indirectly vibrate the cerebrospinal fluid by transmitting vibration or sound wave energy to the maxilla of a subject.

Korean Patent Publication No. 10-2010-0126425

The present invention is to provide a vibrating device for vibrating the cerebrospinal fluid flowing through the ventricle or directly vibrating the ventricle.

The vibration device of the present invention includes at least one of a first vibrator installed in at least one of a soft membrane, a subarachnoid space, arachnoid membrane, a dura mater, a skull, and a head skin, and a second vibrator installed in a ventricle, the first The vibrator may generate a first energy for vibrating the cerebrospinal fluid flowing through the subarachnoid space, and the second vibrator may generate a second energy for vibrating the cerebrospinal fluid flowing through the ventricle.

The vibration device of the present invention includes a second housing portion disposed in the ventricle; a second vibrating unit installed in the second housing unit and generating at least one of ultrasonic waves, sound waves, and physical vibrations; a second control unit installed in the second housing unit and configured to control the second vibrating unit; a second power supply unit for supplying power to the second vibrating unit; and the second power supply unit includes a second battery built into the second housing unit, or the head is electrically connected to the second housing unit. It may include a second power supply means connected to a wire penetrating up to the bone (Skull).

The vibration device of the present invention is disposed in the ventricle (cerebral ventricle), and vibrates the cerebrospinal fluid in a state in which it is in face-to-face contact with the cerebrospinal fluid flowing through the ventricle or it can vibrate the ventricle in a state in which it is in face-to-face contact with the inner wall surface of the ventricle. .

In the present invention, a vibrator is installed inside the skull, and vibration can be applied to the brain cells inside the soft membrane through the vibration of the vibrator.

Based on the position of the vibrator inside the skull, the vibrator may be disposed between the skull and the soft membrane. For example, the vibrator installed inside the skull may be disposed in the subarachnoid space or the ventricle.

The vibrator installed on the inside of the skull may be fixed on the inside of the skull.

The vibrator disposed inside the skull may be connected to a power source outside the skull by wire.

The vibration device according to the present invention can remove harmful proteins that cause various brain diseases through vibration.

The vibration device of the present invention can effectively prevent or treat brain diseases such as Alzheimer's disease or hydrocephalus, which may be caused by protein aggregation or clogging of the cerebrospinal fluid, by smoothing the flow of cerebrospinal fluid.

1 is a schematic diagram showing a vibration device of the present invention.
Figure 2 is a first schematic view showing the installation position of the first vibrator of the present invention.
Figure 3 is a second schematic view showing the installation position of the first vibrator of the present invention.
4 is a schematic view showing a first fixing part.
5 is a schematic view showing an installation position of the second vibrator of the present invention.
6 is a schematic view showing a second vibrator installed in the ventricle.
7 is a schematic view showing a surgical device for injecting a first vibrator or a second vibrator into the brain through the front of the head.
8 is a schematic view showing a surgical device for injecting a first vibrator or a second vibrator into the brain through the back of the head.
9 is a schematic view showing a probe inserted up to the ventricle.
10 is a schematic view showing an endoscope inserted into the brain through the nasal cavity.
11 is a schematic diagram illustrating a surgical device according to an embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings, embodiments of the present invention will be described in detail so that those of ordinary skill in the art to which the present invention pertains can easily implement them. However, the present invention may be embodied in many different forms and is not limited to the embodiments described herein. And in order to clearly explain the present invention in the drawings, parts irrelevant to the description are omitted, and similar reference numerals are attached to similar parts throughout the specification.

In the present specification, duplicate descriptions of the same components will be omitted.

Also, in this specification, when it is mentioned that a certain element is 'connected' or 'connected' to another element, it may be directly connected or connected to the other element, but another element in the middle. It should be understood that there may be On the other hand, in this specification, when it is mentioned that a certain element is 'directly connected' or 'directly connected' to another element, it should be understood that the other element does not exist in the middle.

In addition, the terms used herein are used only to describe specific embodiments, and are not intended to limit the present invention.

Also, in this specification, the singular expression may include the plural expression unless the context clearly dictates otherwise.

Also in this specification, terms such as 'include' or 'have' are only intended to designate that the features, numbers, steps, operations, components, parts, or combinations thereof described in the specification exist, and one or more It should be understood that the existence or addition of other features, numbers, steps, operations, components, parts or combinations thereof is not precluded in advance.

Also in this specification, the term 'and/or' includes a combination of a plurality of listed items or any of a plurality of listed items. In this specification, 'A or B' may include 'A', 'B', or 'both A and B'.

Also, in this specification, detailed descriptions of well-known functions and configurations that may obscure the gist of the present invention will be omitted.

1 is a schematic diagram showing a vibration device of the present invention.

The vibration device shown in FIG. 1 may include various vibrators that induce sound waves, ultrasonic waves, and physical vibrations.

The vibration device of the present invention is directly injected into the brain, and can be a source of vibration directly vibrating in the brain.

The vibrating device of the present invention is a first vibrator 500 installed directly in a first section from the outer surface of the soft membrane to the outer surface of the head skin, a second section directly installed in the second section from the inner wall surface of one side of the ventricle to the inner wall surface of the other side of the ventricle At least one of the two vibrators 600 may be included.

For example, the first vibrator 500 may be installed in at least one of a soft membrane, a subarachnoid space, an arachnoid membrane, a dura mater, a skull bone, and a head skin. The second vibrator 600 may be installed in the ventricle.

The first vibrator 500 may be a source for vibrating the cerebrospinal fluid existing in the first section. The first vibrator 500 may generate first energy to vibrate the cerebrospinal fluid flowing through the subarachnoid space. The first energy may include sound wave energy, ultrasonic energy, or physical vibration energy. For example, the first vibrator 500 installed on the inner surface of the skull (skull) may generate vibration of a frequency targeting the cerebrospinal fluid flowing through the subarachnoid space. The vibration generated by the first vibrator 500 may be propagated to the cerebrospinal fluid via the dura mater and the arachnoid membrane in order. The first vibrator 500 installed on the outer surface of the skull or the outer surface of the skin of the head may generate bone conduction vibrations propagating along the skull and vibrate the cerebrospinal fluid flowing through the subarachnoid space using the bone conduction vibrations. .

The second vibrator 600 may be a source for vibrating the cerebrospinal fluid existing in the second section. The second vibrator 600 may generate a second energy to vibrate the cerebrospinal fluid flowing through the ventricle. The second energy may include sound wave energy, ultrasonic energy, or physical vibration energy.

In one aspect, the present invention provides a cerebrospinal fluid vibration device for preventing or treating cerebral diseases comprising one or more vibrators in contact with the cerebrospinal fluid.

In the present invention, cerebrospinal fluid (CSF) is a transparent liquid located inside the brain and spinal cord, which is generated in the choroid plexus of the cerebral ventricle and circulates in the ventricles in turn, and then through the arachnoid granulation. It is excreted and absorbed into the venous circulation. The cerebrospinal fluid moves to the interstitial space by the hydrostatic pressure difference through the fenestrated capillary, and the fluid moves from the choroid plexus to the ventricle by the osmotic pressure difference.

In the cerebrospinal fluid vibration device of the present invention, one or more vibrators may be installed in the cerebral ventricle or subarachnoid space. The ventricle may be one or more selected from the group consisting of the left ventricle, the right ventricle, the third ventricle, and the fourth ventricle.

In the present invention, the ventricle is a term referring to four interconnected empty spaces present in the brain, and cerebrospinal fluid is produced and circulated in the ventricle and fills the ventricle. The four spaces of the ventricle are called the lateral ventricle, the third ventricle, and the fourth ventricle, respectively, depending on their location. Each ventricle is connected to each other through a narrow passageway, which is an interventricular foram (also called foramen of Monro) that connects both lateral ventricles and the third ventricle, the third and fourth ventricles. cerebral aqueduct (also called aqueduct of Sylvius), median aperture (also called foramen of Magendie) connecting the fourth ventricle with the subarachnoid space and a lateral aperture (also called foramen of Luschka).

In the present invention, the subarachnoid space refers to a space filled with cerebrospinal fluid between the arachnoid and the pia mater.

The cerebrospinal fluid vibrating device of the present invention may further include a probe 20 that is inserted through the perforated skull. The probe 20 may include an endoscope. Through the endoscope, one or more vibrators of the cerebrospinal fluid vibrating device may be installed at an appropriate location in the brain to come into contact with the cerebrospinal fluid.

The cerebrospinal fluid vibrating device of the present invention may further include a catheter or stent inserted through the perforated skull.

In the cerebrospinal fluid vibrating device of the present invention, one or more vibrators can induce vibration of the cerebrospinal fluid through one or more vibrating units selected from the group consisting of ultrasonic waves, sonic waves, supersonic waves, and piezo. have.

The cerebrospinal fluid vibration device of the present invention can prevent or treat brain diseases through vibration of the cerebrospinal fluid. Specifically, the brain disease may be a neurodegenerative disease or hydrocephalus.

In the present invention, a neurodegenerative disease refers to a condition in which nerve cells are degenerated. Examples of neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, Lewy body disease, frontotemporal lobe degeneration, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, and the like. Aggregation is observed. Preferably, in the present invention, the neurodegenerative disease is Alzheimer's disease.

The cerebrospinal fluid vibration device of the present invention can remove or reduce the accumulation of abnormal proteins in neurodegenerative diseases through cerebrospinal fluid vibration. Specifically, the cerebrospinal fluid vibration device of the present invention can eliminate or reduce the accumulation of amyloid beta or tau protein in the brain (eg, temporal lobe, hippocampus, etc.) in Alzheimer's disease through vibration of the cerebrospinal fluid.

In the present invention, hydrocephalus is a phenomenon in which cerebrospinal fluid in the brain accumulates, and is accompanied by an increase in intracranial pressure. For example, the midbrain or interventricular hole may be narrowed or blocked due to hemorrhagic stroke, etc., thereby causing disturbance in the circulation of cerebrospinal fluid generated in the lateral ventricle. For this reason, when the amount of cerebrospinal fluid in the lateral ventricle or the third ventricle becomes excessive, the intraventricular pressure increases.

The cerebrospinal fluid vibration device of the present invention can alleviate or improve cerebrospinal fluid stagnation in hydrocephalus through cerebrospinal fluid vibration. To this end, the cerebrospinal fluid vibrating device of the present invention may further include a device capable of reducing intraventricular pressure, for example, a conduit capable of sucking the cerebrospinal fluid used in a ventriculoperitoneal shunt.

In one aspect, the present invention comprises the steps of perforating the skull; And it provides a method of installing a cerebrospinal fluid vibrating device for preventing or treating encephalopathy, comprising the step of contacting one or more vibrators with cerebrospinal fluid through the perforated skull.

The skull is largely composed of four parts: the skull, facial bones, tongue bones, and inner ear bones. Before perforating the skull, after obtaining the correct coordinates on the skull by considering the desired location of one or more vibrators in the brain, perforation is performed. can be carried out.

In the installation method of the cerebrospinal fluid vibration device according to the present invention, one or more vibrators may be installed in the ventricle s2 or the subarachnoid space s2. The method of approaching the vibrator to the ventricle s2 or the subarachnoid space s1 can be performed with reference to brain surgery methods known in the art, for example, Shim, Kyu-Won, et al. "Transventricular endoscopic fenestration of intracellar arachnoid cyst." Neurosurgery 72.4 (2013): 520-528.] et al.

The installation method of the cerebrospinal fluid vibrating device according to the present invention may further include the step of inserting the endoscope through the perforated skull.

The installation method of the cerebrospinal fluid vibrating device according to the present invention may further include inserting a catheter or a stent through the perforated skull.

In one aspect, the present invention provides a step for perforating the skull; contacting the one or more vibrators with cerebrospinal fluid through the perforated skull; and delivering one or more selected from the group consisting of ultrasonic waves, sound waves, and piezoelectricity to the cerebrospinal fluid through one or more vibrators in the installed vibration device.

The brain disease prevention or treatment method may be performed in mammals including humans. Specifically, the prevention or treatment method may be performed on a human or a mammal other than a human.

The method for preventing or treating brain disease according to the present invention may further include inserting an endoscope through the perforated skull.

The method for preventing or treating brain disease according to the present invention may further include inserting a catheter or a stent through the perforated skull.

The brain disease prevention or treatment method according to the present invention can be performed together with one or more conventional brain disease surgical methods, such as deep brain stimulation, ventriculoperitoneal shunt, or endoscopic ventriculostomy using an endoscope.

The method for preventing or treating brain disease according to the present invention may further include determining the level of brain disease progression by measuring the expression level of a brain disease-related biomarker from the cerebrospinal fluid.

Determining the level of progression of the brain disease may include: collecting a cerebrospinal fluid sample; measuring the expression level of a brain disease-related biomarker in the cerebrospinal fluid sample; measuring the expression level of the biomarker in a normal control sample; and comparing the expression level of the biomarker measured in the cerebrospinal fluid sample with the expression level of the biomarker measured in the normal control sample to determine the progression level of the brain disease.

The biomarker in the cerebrospinal fluid sample may be, for example, tau protein (including phosphorylated/unphosphorylated tau protein, respectively), amyloid beta 40, 42, Gap43, ubiquitin, and AD7C-NTP, but is not limited thereto, and Alzheimer's disease in the cerebrospinal fluid is known in the art. Proteins known as disease biomarkers are included without limitation. For example, CR1, BIN1, CD2AP, EPHA1, CLU, MS4A6A, PICALM, ABCA7, CD33, HLA-DRB5, PTK2B, SORL1, SLC24A4, DSG2, INPP5D, MEF2C, NME8, ZCWPW1, CELF1, FASS4 through large patient population analysis It has been shown that the gene is associated with late-onset Alzheimer's disease (Lambert et al., Nature Genetics, 2013). In addition, it was reported that mutations in ABCA7, CLU, DSG2, EPHA1, FERMT2, PICALM, PTK2B, SORL1, and ZCWPW1 genes are associated with amyloid accumulation in the brain through a study on the association between brain images and genes of normal subjects and Alzheimer's patients. (Apostolova et al., JAMA Neurology, 2018). In addition, any known protein such as alpha-synuclein protein seen in Lewy body disease and TDP-43 shown in amyotrophic lateral sclerosis is included without limitation.

In the method for preventing or treating brain disease according to the present invention, the brain disease is a neurodegenerative disease or hydrocephalus, and the detailed description is as described above.

The vibration device of the present invention may include at least one of a first vibrator 500 installed in the subarachnoid space s1, and a second vibrator 600 installed in the ventricle s2.

2 is a first schematic view showing an installation position of the first vibrator 500 of the present invention. 3 is a second schematic view showing an installation position of the first vibrator 500 of the present invention.

The first vibrator 500 may be disposed in a subarachnoid space. The subarachnoid space is a space between the arachnoid mater and the pia mater, and the arachnoid and soft membrane are connected by an Arachnoid trabecula having a columnar fibrous structure.

The first vibrator 500 may directly vibrate the cerebrospinal fluid while in face-to-face contact with the cerebrospinal fluid flowing through the subarachnoid space. Alternatively, the first vibrator 500 may vibrate the corresponding object while in face-to-face contact with the object corresponding to at least one of the Arachnoid mater, the Arachnoid trabecula, and the Pia mater. .

As an example, in order to remove the harmful protein deposited at the first position t1 of the soft membrane, a method of vibrating the first position t1 may be attempted.

The first vibrator 500 for inducing vibration to vibrate the first position t1 may be installed at the soft film position Pp in direct contact with the first position t1. The first vibrator 500 vibrating while in face-to-face contact with the soft membrane position Pp can easily remove the harmful protein formed at the first position t1. In addition, one surface of the first vibrator 500 facing the arachnoid may be in face-to-face contact with the cerebrospinal fluid flowing along the subarachnoid space, and the cerebrospinal fluid may flow through vibration.

The first vibrator 500 installed at the soft membrane position Pp may act as a new harmful component to the brain. Therefore, it may be advantageous that the installation of the first vibrator 500 relative to the soft membrane position Pp is performed only during surgery and is removed from the brain prior to completion of the surgery. On the other hand, the surgery is completed with the first vibrator 500 inserted into the brain, and the first vibrator 500 can act in the brain for a long time. In this case, the first vibrator 500 may be installed at a position Pa of the arachnoid so as to be in face-to-face contact with the arachnoid in order to avoid direct pressure applied to the brain by the first vibrator 500 . Alternatively, the first vibrator 500 may be installed at a spatial position Pt between the arachnoid and the soft membrane.

Since the first vibrator 500 installed at the spatial position Pt is close to the first position t1, it is easy to remove harmful terminal quality existing at the first position t1. In addition, since both the one surface of the first vibrator 500 facing the arachnoid and the other surface of the first vibrator 500 facing the soft membrane are in direct contact with the cerebrospinal fluid, the vibration can be effectively propagated to the cerebrospinal fluid. As a result, the circulation of the cerebrospinal fluid can be made more smoothly.

The first vibrator 500 may include a first housing unit 510 , a first vibrator unit 530 , a first control unit 550 , and a first power source unit 570 .

The first housing unit 510 may be disposed in the subarachnoid space s1. The first housing part 510 may be formed in a polyhedral shape such as a capsule, a sphere, or a curved shape. An empty space in which the first vibrating unit 530 , the first control unit 550 , the first power supply unit 570 , and the like can be mounted may be formed in the first housing unit 510 .

In order to prevent brain damage, the outer surface of the first housing part 510 may be formed to have a perfect curvature. For the same reason, the outer surface of the first housing part 510 may be formed of a flexible and soft material, for example, rubber, silicone, soft synthetic resin, or the like.

The first vibrating unit 530 may be installed in an empty space inside the first housing unit 510 . The first vibrator 530 may vibrate the cerebrospinal fluid. Alternatively, the first vibrating unit 530 may vibrate at least one of an Arachnoid mater, an Arachnoid trabecula, and a Pia mater.

The first vibrator 530 may generate at least one of ultrasonic waves, sound waves, and physical vibrations. For example, the first vibrator 530 may include at least one of a piezoelectric motor, a voice coil motor, a sound wave generator, and an ultrasonic generator.

The first control unit 550 may be installed in an empty space inside the first housing unit 510 . The first controller 550 may control the first vibrator 530 . For example, the first control unit 550 may control the first vibrating unit 530 to operate every set period. Alternatively, the first control unit 550 may change the vibration type of the first vibrating unit 530 every set period. For example, the first control unit 550 may vibrate the first vibrating unit 530 in the first direction in the first period. The first controller 550 may vibrate the first vibrator 530 in the second direction in the second period. The first direction may include a direction perpendicular to the arachnoid or soft membrane. The second direction may include a direction parallel to the arachnoid or soft membrane. By changing the direction of vibration, it is possible to easily separate harmful proteins deposited on the tissue surface.

The first power supply unit 570 may supply power to at least one of the first vibrating unit 530 and the first control unit 550 .

The first power supply unit 570 may include a first battery built in the first housing unit 510 . Alternatively, the first power supply unit 570 is electrically connected to the first housing unit 510 and supplies a first power connected to the first conductive line passing through the arachnoid membrane, the dura mater, and the skull in order. means may be included. A battery provided outside the first housing unit 510 and various commercial power sources may correspond to the first power supply means.

When the application of the first battery or the application of the first power supply means is required only at the time of surgery, both methods are not particularly difficult.

However, according to the fixed method in which the first vibrator 500 is inserted into the brain and the head 90 is sutured, the first vibrator 500 must remain in the patient's head 90 and continuously operate. do.

When the first battery embedded in the first housing unit 510 is applied in a fixed manner, reoperation may be required for replacement and charging of the first battery. When the first power supply means disposed outside of the first housing unit 510 is applied, since a power source such as a battery may be disposed outside the dura mater, recharging and replacement may be facilitated.

The first power supply means may include a wireless charging pad disposed between the skull and the skin of the head. The wireless charging pad may be electrically connected to the battery inside the first housing unit 510 disposed in the subarachnoid space or the ventricle through a conductive wire.

When charging of the battery is required while the wireless charging pad is covered with the skin of the head, the first battery inside the housing may be charged by placing the wireless charger on the outside of the skin of the head to be placed face to face. As a result, the first vibrator 530 or the first controller 550 driven by the battery may operate for a long period of time. To protect the patient from heat, the wireless charging pad may be sealed inside the heat dissipation pad.

On the other hand, in the case of the fixed type, the first vibrator 500 installed in the brain needs to be fixed at the initial installation position without flowing to another place by the flow of cerebrospinal fluid.

4 is a schematic diagram illustrating the first fixing part 590 .

A plurality of first fixing parts 590 may be provided in the first vibrator 500 to adhere to the initial installation position. The first fixing part 590 may be formed to protrude from the first housing part 510 disposed in the subarachnoid space s1.

A first locking means 591 wound around an arachnoid pole may be provided at an end of each first fixing part 590 .

The first vibrating unit 530 may operate in a state of being fixed to a set position in the subarachnoid space together with the first housing unit 510 by the first locking means 591 wound around the subarachnoid pole.

The first fixing part 590 may be formed in a shape of a thin protrusion or a rod extending in a radial direction with respect to the first housing part 510 . An end of the first fixing part 590 may form a ring bent in the forward direction. In this case, the ring formed at the end of the first fixing part 590 may correspond to the first locking means 591 .

The extending direction of the first fixing part 590 may be parallel to the arachnoid. In this case, when the first housing part 510 is viewed along an axis perpendicular to the arachnoid, the forward direction may be either a clockwise direction or a counterclockwise direction. All of the first locking means 591 formed at the ends of the plurality of first fixing parts 590 protruding from the first housing part 510 may be bent in the forward direction. The forward direction may be either clockwise or counterclockwise. For example, in FIG. 4 , the plurality of first locking means 591 may be formed in a ring shape bent in a counterclockwise direction.

The first locking means 591 may be formed of a material having elasticity, such as rubber, silicone, soft synthetic resin, or the like. When the first housing part 510 rotates counterclockwise, the first locking means 591 may be caught on or wound on the arachnoid pole formed to be inclined on the arachnoid.

When the first locking means 591 is caught on the arachnoid pole, the first housing part 510 and the first vibrating part 530 may stay in their current positions regardless of the flow of the cerebrospinal fluid.

When the first housing part 510 rotates in the reverse direction, for example, in a clockwise direction, the first locking means 591 yields to the rotational force and the shape wound around the arachnoid pole is deformed, and may escape from the arachnoid pole. When the first locking means 591 is released from the subarachnoid pole, the first housing part 510 may be moved to another location in the subarachnoid space or discharged from the brain of the patient.

5 is a schematic diagram showing an installation position of the second vibrator 600 of the present invention. 6 is a schematic diagram showing the second vibrator 600 installed in the ventricle.

The second vibrator 600 may be disposed in the ventricle (cerebral ventricle) s2. The second vibrator 600 may vibrate the cerebrospinal fluid while in face-to-face contact with the cerebrospinal fluid flowing through the ventricle. Alternatively, the second vibrator 600 may vibrate the ventricle in a face-to-face contact with the inner wall surface of the ventricle.

For example, in order to remove the harmful protein deposited at the second position t2 of the inner wall of the ventricle, a method of vibrating the second position t2 may be attempted.

The second vibrator 600 for inducing vibration to vibrate the second position t2 may be installed at a position P1 of the inner wall of the ventricle in direct contact with the second position t2. The second vibrator 600 vibrating while in face-to-face contact with the inner wall surface position Pl may remove the harmful protein formed at the second position t2. In addition, one surface of the second vibrator 600 exposed to the empty space of the ventricle may vibrate and flow the cerebrospinal fluid flowing along the ventricle.

In order to vibrate the second position t2 or flow the cerebrospinal fluid, the second vibrator 600 may be installed on a spatial position Ps that is spaced apart from the second position t2 and faces the second position t2. A second fixing part may be provided in the second vibrator 600 to be disposed at the spatial position Ps.

Similar to the first vibrator 500, the second vibrator 600 installed at a position Pl on the inner wall of the ventricle is likely to negatively press the brain. Therefore, it may be advantageous that the installation of the second vibrator 600 to the ventricular inner wall surface position Pl is temporarily performed only during the operation and is removed from the brain before the operation is completed. When the input state of the second vibrator 600 is temporarily maintained, the position of the second vibrator 600 may be appropriately adjusted through a rod-shaped guide part or the like.

Even in the case of a fixed type in which the operation is terminated with the second vibrator 600 inserted into the ventricle, the installation position of the second vibrator 600 may be adjusted by a guide unit or the like.

The second vibrator 600 may be provided with a second housing unit 610 , a second vibrator unit, a second control unit, and a second power supply unit.

The second housing portion may be disposed in the ventricle. The second housing part may be formed in a polyhedral, spherical, or curved shape similar to the first housing part 510 . However, in the case of the ventricle, the installation space of the second vibrator 600 may be several tens of times larger than that of the subarachnoid space. This may mean that enormous energy is required compared to the subarachnoid space to flow the cerebrospinal fluid.

The second vibrating unit may be installed in an empty space inside the second housing unit. The second vibrating unit may vibrate the cerebrospinal fluid. Alternatively, the second vibrating unit may directly vibrate the inner wall surface of the ventricle.

The second vibrating unit may generate at least one of a super-amp wave, a sound wave, and a physical vibration. As an example, the second vibrator may include at least one of a piezoelectric motor, a voice coil motor, a sound wave generator, and an ultrasonic generator.

In order to effectively flow the cerebrospinal fluid, the second vibrating unit may include a screw that moves the cerebrospinal fluid. An actuator such as a motor for rotating the screw may be provided in the second vibrating unit.

In order not to damage the brain by the screw, the second housing part may include a cover covering the screw.

The cover may be formed in a mesh structure having a plurality of holes through which the cerebrospinal fluid can pass. The screw surrounded by the cover can flow the communicating cerebrospinal fluid through the orifice of the cover without direct contact with the ventricular lining.

The second control unit may be installed in an empty space inside the second housing unit. The second control unit may control the second vibrating unit. For example, the second control unit may vibrate the second vibrator at every set period. Alternatively, the second control unit may change the vibration type of the second vibrator at every set period.

The second power unit may supply power to at least one of the second vibrator and the second control unit.

The second power unit may include a second battery built into the second housing unit. Alternatively, the second power supply unit may include a second power supply unit connected to a conductive wire penetrating up to the skull layer while being electrically connected to the second housing unit. A battery, commercial power supply, etc. provided outside the second housing unit may correspond to the second power supply means.

A large-capacity battery may be required for the normal operation of the screw. A large-capacity battery is difficult to put into the ventricle due to the volume problem, and there is a problem of recharging. Accordingly, the battery may be disposed between the cranial layer and the head skin. The battery disposed outside the second housing may be electrically connected to the second vibrating unit installed in the second housing by a conducting wire.

The second power supply means may include a wireless charging pad disposed between the skull and the skin of the head. The wireless charging pad may wirelessly charge a second battery inside the second housing unit disposed in the ventricle through a wire or a battery disposed between the skull and the skin of the head. The wireless charging pad may be electrically connected to the second battery through a conductive wire, or electrically connected to a second power supply means disposed between the dura mater and the skin of the head.

A fixed procedure in which the input state of the second vibrator 600 must be continuously maintained may be required. In this case, the second vibrator 600 may vibrate the ventricle while staying in the ventricle even after the operation is completed and the head skin is sutured. At this time, the second vibrator 600 disposed in the ventricle needs to be fixed without departing from the initial arrangement position. If the second vibrator 600 flows, there is a fear that the hole connecting the ventricle and the ventricle is blocked by the second vibrator 600 . Accordingly, maintaining the current position of the second vibrator 600 may be very important.

The second vibrating unit may be installed in the second housing unit disposed in the ventricle, and vibrate the cerebrospinal fluid or the ventricle. In this case, a plurality of second fixing parts 690 for fixing the second vibrating part and the second housing to the initial setting position may be provided.

The plurality of second fixing parts 690 may be formed to protrude from the second housing part. The second fixing part 690 may be formed in a shape such as an insect leg.

The second fixing part 690 may support the second housing part so that the second housing part floats in the middle of the ventricle without contacting the inner wall surface of the ventricle.

As an example, a specific second fixing part of the plurality of second fixing parts 690 may extend to be supported on the inner wall surface of one side of the ventricle. The other second fixing part of the plurality of second fixing parts 690 may extend to be supported on the inner wall surface of the other side of the ventricle. The second housing portion by the plurality of second fixing portion 690 may be supported in the ventricle similar to the so-called biceps state. Six or more second fixing parts 690 may be formed so that a plurality of biceps states are generated around the second housing part.

The second housing unit and the second vibrating unit may be fixed to the setting position of the ventricle by a specific second fixing unit and another second fixing unit extending toward different directions. The second vibrating unit operates in a state fixed to the set position by the plurality of second fixing units 690, and may vibrate or flow the cerebrospinal fluid.

If the end of the second fixing portion 690 supported on the inner wall of the ventricle is formed to be sharp, damage to the brain may occur. In order to prevent brain damage, the second fixing part 690 may include a flexible and resilient rubber, silicone, or synthetic resin material. In addition, the support means 691 in contact with the ventricle in the second fixing portion 690 may be formed in a structure that does not damage the ventricle. The support means 691 may be integrally formed with the second fixing part 690 .

For example, the support means 691 may extend gently and curvedly from the end of the second fixing part 690 extending from the second housing part like an insect's leg.

In the perfectly curved support means (691), the sharp end can be formed to protrude the most toward the inner wall of the ventricle among the gently curved middle part of the battery support means (691). Therefore, the ventricle is not the end of the support means (691), but the center portion of the rolled line contact or surface contact, the ventricle can be protected.

7 is a schematic diagram showing the surgical device 1 for injecting the first vibrator 500 or the second vibrator 600 into the brain through the front of the head. 8 is a schematic diagram showing the surgical device 1 for injecting the first vibrator 500 or the second vibrator 600 into the brain through the back of the head.

The surgical device 1 may be provided with a probe 20 that passes through the skull layer and enters the brain from the outside.

A hollow extending along the axial direction may be formed in the probe 20 . A camera port equipped with a video port through which a video signal is communicated and a lighting port for supplying power to a light that brightly illuminates the brain can be inserted into the hollow. A guide unit for introducing the first vibrator 500 or the second vibrator 600 may be inserted into the hollow. A suction port for sucking air or blood may be inserted into the hollow.

If the skin of the head is removed using tools such as a drill or a knife, and the skull is cut or polished, the brain surrounded by the dura mater can be exposed to the outside.

When the first vibrator 500 is put in, the end of the probe 20 may be put into the subarachnoid space.

When the second vibrator 600 is put in, the end of the probe 20 may be put into the ventricle.

9 is a schematic diagram showing the probe 20 inserted to the ventricle.

When the distal end of the probe 20 enters the ventricle, the probe 20 is fixed, and the second vibrator 600 and the guide unit may be inserted through the hollow of the probe 20 . When the guide part is pushed into the probe 20, the second vibrator 600 may be pushed into the ventricle by the guide part.

10 is a schematic view showing an endoscope inserted into the brain through the nasal cavity.

The endoscope 80 injected into the nasal cavity z1 through the nostril may penetrate the sphenoid sinus z2 and enter the brain. The endoscope 80 passing through the sphenoid sinus in position can easily enter the ventricle. On the other hand, access to the subarachnoid space may be undesirable. Therefore, the surgical device 1 using the endoscope inserted through the nasal cavity may be suitable for the installation of the second vibrator 600 .

11 is a schematic diagram showing a surgical device 1 according to an embodiment of the present invention.

The surgical device 1 of the present invention may include a head clamp 3 , an arc arm mechanism 4 , a probe 20 , a guide unit, and a first vibrator 500 or a second vibrator 600 .

The head clamp 3 may be mounted on the patient's head 90 .

The arc arm mechanism 4 can be assembled to the head clamp 3 .

The probe 20 has a hollow extending in the longitudinal direction, moves along the arc arm, and can be inserted into the patient's head 90 at a set position.

When one end of the probe 20 is inserted into the patient's head 90 , the guide part may be inserted into the hollow of the probe 20 through the other end of the probe 20 exposed to the outside of the head 90 .

The first vibrator 500 and the second vibrator 600 may be inserted into the hollow through the other end of the probe 20 exposed to the outside. The first vibrator 500 and the second vibrator 600 slide along the hollow, and may be output into the patient's brain through one end of the probe 20 inserted into the patient's head 90 . The first vibrator 500 and the second vibrator 600 protruding from the probe 20 may be disposed in the patient's head 90 .

The guide part may be provided with at least one of an adjustment means, a conducting wire, and a rotation means.

The adjusting means may physically move the first vibrator 500 or the second vibrator 600 toward the other end of the probe 20 or adjust the installation position. The adjusting means may include a thin rod for pushing each vibrator, a thin rod for grabbing the vibrator, and the like. For example, if the vibrator is inserted into the hollow of the probe 20 and then the guide part is inserted into the probe 20 and pushed, the vibrator located in front of the guide part may be pushed into the guide part and pushed toward the brain of the patient.

The conductive wire may supply power to the first vibrator 500 or the second vibrator 600 . When each vibrator is disposed at one end of the guide unit, a power source for providing power to the vibrator may be disposed at the other end of the guide unit. The vibrator and the power source may be electrically connected through a conductive wire provided in the guide part. Power from the power source may be transmitted to the vibrator provided in the vibrator through the wire and operate the vibrator.

The rotating means may be provided with a rotating means for rotating the first vibrator 500 or the second vibrator 600 output through the other end of the probe 20 about an imaginary line coaxial to the probe 20 .

A plurality of first fixing units 590 may protrude from the first housing unit 510 on which the first vibrating unit 530 is mounted on the first vibrator 500 . The first fixing part 590 may be provided with a first locking means 591 that is locked to the subarachnoid pole existing in the subarachnoid space.

A plurality of second fixing units 690 may protrude from the second housing unit on which the second vibrator is mounted on the second vibrator 600 . The second fixing part 690 may be provided with a support means 691 that is supported on the inner wall surface of the ventricle.

In order to lock the plurality of first locking means 591 to the subarachnoid space or to support the plurality of support means 691 on the inner wall surface of the ventricle, the first housing part 510 or the second housing part needs to be rotated by a set angle. there is The rotating means may be connected to the first housing unit 510 or the second housing unit to be constrained to rotation about an imaginary line coaxial with the probe 20 . Through the constraint, the rotating means may rotate together with the first vibrator 500 or the second vibrator 600 . The rotating means may be rotated manually by a medical staff or may be rotated using a separate actuator.

After the head clamp 3 is mounted on the head 90 of the patient 7 , a process of measuring and identifying the surgical site through MRI may be performed. The arc arm mechanism 4 may be assembled to the head clamp 3 after fixing the head clamp 3 to the bed immediately before surgery. The arc path of the arc arm mechanism 4 may be provided with a position adjusting means 6 capable of adjusting the surgical site. The probe 20 moves along the arc path of the arc arm mechanism 4 and can be fixed on the correct surgical site through the scale of the positioning means.

The probe 20 may be inserted into the brain through a patient's nose in addition to the method of being inserted into the brain through the skull layer. Specifically, the hollow probe 20 may penetrate into the brain of the patient through the skull layer of the patient or the sphenoid sinus in the nose.

When the one end side end of the probe 20 inserted into the patient's brain reaches the target position, the guide part may be inserted into the hollow through the other end of the probe 20 exposed outside the patient's head.

The first vibrator 500 or the second vibrator 600 is inserted into the hollow through the other end of the probe 20 exposed to the outside, and is inserted into the brain of the patient through one end of the probe 20 by the guide unit. can be emitted.

The first vibrator 500 includes a first vibrating unit 530 for inducing vibration, a first housing unit 510 on which the first vibrating unit 530 is mounted, and the second vibrator when released into the subarachnoid space of the patient. A plurality of first fixing parts 590 extending in all directions from the first housing part 510 may be provided.

The second vibrator 600 includes a second vibrating unit that induces vibration, a second housing unit on which the second vibrating unit is mounted, and a plurality of second units that are spread out from the second housing unit in all directions when emitted to the cerebral ventricle of the patient. A fixing part 690 may be provided.

When the first vibrating part 530 is released into the subarachnoid space, the guide part is made centered on an imaginary line coaxial to the probe 20 so that the plurality of first fixing parts 590 are locked to the Arachnoid trabecula. 1 The housing may be rotated by a first set angle.

When the guide unit emits the second vibration unit to the ventricle, the plurality of second fixing units 690 are respectively supported on the inner wall surface of one side and the inner wall surface of the other side of the patient's ventricle. may be rotated by a second set angle.

The surgical method or the vibrator installation method of the present invention may include inserting the hollow probe 20 into the patient's brain through the skull bone layer or the sphenoid sinus in the nose.

The surgical method or the vibrator installation method of the present invention may include, when the insertion of the probe 20 is completed, inserting the vibrator into the hollow of the probe 20 while the vibrator is mounted on the guide unit.

The surgical method or the vibrator installation method of the present invention may include pushing the guide unit into the probe 20 to release the vibrator into the patient's brain.

The surgical method or the vibrator installation method of the present invention may include providing an operation start signal of the vibrator mounted on the vibrator through a guide unit or providing driving power of the vibrator unit through the guide unit.

According to the present invention, the vibrator that induces vibration is physically injected into the subarachnoid space or the ventricle directly, and the vibration can be directly transmitted to the corresponding space.

On the other hand, a means for replacing or removing each vibrator disposed in the brain may be provided.

For example, when the end of one end of the probe reaches a position facing the first vibrator or the second vibrator disposed in the brain, a grab portion inserted into the hollow through the other end of the probe exposed outside the patient's head may be provided. have.

The grab portion output through one end of the probe may grab the first vibrator or the second vibrator. A plurality of fingers, a manipulator, and the like for gripping the vibrator with the vibrator interposed therebetween may be provided in the grab part.

When the direction of rotation of the guide unit for fixing the first vibrator or the second vibrator in the brain is defined as the forward direction, the grab unit may rotate in the reverse direction. For example, when grabbing for the first vibrator or the second vibrator is completed, the grab unit may be retracted toward the outside of the patient's head while rotating in a reverse direction opposite to the forward direction. Each fixing part may be separated from the head tissue by the reverse rotation of the grab part. Due to the retraction of the grab part, the fixing part (the first fixing part or the second fixing part) of each vibrator may be introduced into one end of the probe together with each housing part and discharged to the outside of the patient's head through the other end of the probe.

Although the embodiment of the present invention has been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention as defined in the following claims are also presented. It belongs to the scope of the invention.

1....surgical device 3...head clamp
4...Arc arm mechanism 6...Positioning means
7...Patient 20...Probe
90...head 500...first oscillator
510 ... first housing part 530 ... first vibrating part
550...first control unit 570...first power supply unit
590...first fixing part 591...first locking means
600...Second vibrator 610...Second housing part
690...Second fixing part 691...Supporting means

Claims (3)

A soft membrane, subarachnoid space, arachnoid membrane, dura mater, skull bone, and at least one of a first vibrator installed in at least one of the head skin, and a second vibrator installed in the ventricle,
The first vibrator generates a first energy for vibrating the cerebrospinal fluid flowing through the subarachnoid space,
The second vibrator is a vibration device for generating a second energy for vibrating the cerebrospinal fluid flowing through the ventricle.
a second housing portion disposed in the ventricle;
a second vibrating unit installed in the second housing unit and generating at least one of ultrasonic waves, sound waves, and physical vibrations;
a second control unit installed in the second housing unit and configured to control the second vibrating unit;
a second power supply unit for supplying power to the second vibrating unit;
The second power supply unit includes a second battery built into the second housing unit, or includes a second power supply unit connected to a wire penetrating to the skull while being electrically connected to the second housing unit. vibrating device.
3. The method of claim 2,
A plurality of second fixing parts protruding from the second housing part are provided,
A specific second fixing part of the plurality of second fixing parts extends to be supported on one side of the inner wall surface of the ventricle,
Another second fixing part of the plurality of second fixing parts is extended to be supported on the other side inner wall surface of the ventricle,
The second housing unit and the second vibrating unit are fixed to the setting position of the ventricle by the specific second fixing unit and the other second fixing unit,
The second vibrating unit operates in a state of being fixed to the set position.

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