KR20210129154A - High-concentration hydrogen suction device used for hydrogen suction cosmetic method and hydrogen suction cosmetic method - Google Patents

Abstract

The present invention provides a hydrogen aspiration cosmetic method that can promote improvement in skin condition when high-concentration hydrogen-containing gas air is routinely ingested into the body by oral or nasal suction under natural breathing, and a high-concentration hydrogen suction suitable for use in the hydrogen suction cosmetic method provide the device. The present hydrogen inhalation cosmetic method can non-therapeutically promote improvement of skin condition by routinely orally or nasally aspirating a high-concentration hydrogen-containing gas generated from a hydrogen generating means. In addition, the high-concentration hydrogen suction device used in the present hydrogen suction cosmetic method includes a hydrogen generating means for generating and emitting hydrogen, and hydrogen for guiding a high-concentration hydrogen-containing gas in which hydrogen emitted from the hydrogen generating means and environmental air are mixed to the acetabulum of the human body. It has a conveying means and an attachment for orally or nasally sucking a high concentration hydrogen-containing gas from the said hydrogen conveying means.

Description

High-concentration hydrogen suction device used for hydrogen suction cosmetic method and hydrogen suction cosmetic method

The present invention provides a hydrogen aspiration cosmetic method that can promote improvement in skin condition when high-concentration hydrogen-containing gas air is routinely ingested into the body by oral or nasal suction under natural breathing, and suitable for use in the hydrogen suction cosmetic method It relates to a high-concentration hydrogen suction device.

Recently, the effectiveness of hydrogen has been attracting attention in human clinical trials, and various studies in medical applications are being actively conducted. Methods for administering hydrogen into the human body include intravenous administration, oral administration of an aqueous solution, gas inhalation (nasopharyngeal aspiration), and the like, and methods for introduction into the body are wide.

However, in the past, a clear medical clinical trial on gas aspiration among hydrogen administration methods has not been provided. Patent literature as the result has been provided (Non-Patent Literature 1, etc.).

In such a situation, the inventor, who is a provider of a device capable of routinely inhaling hydrogen, is conducting various clinical trials, paying attention to the biological response by “commercial suction” of hydrogen, for example, brain stress reduction, The demonstration result that a remarkable influence is recognized (patent document 1), and the demonstration result that the improvement of the living function of the person suspected of mild cognitive impairment (MCI), and prevention/improvement of a cognitive function are provided.

On the other hand, hydrogen intake has been attracting attention in the cosmetic industry as well, and a method of orally ingesting hydrogen-containing beverages (so-called hydrogen water) is known. However, there are few clinical trials to the extent that improvement of a specific site is clearly recognized by oral intake, and this was considered to be a misunderstanding about the intake of hydrogen in the body and a condition for inhibition of development promotion. In fact, in the case of oral intake of so-called hydrogen water, it was difficult to maintain the hydrogen content in hydrogen-containing beverages or to control the amount of intake in the body, making it difficult to conduct empirical tests that could be clinical trials.

Under this circumstance, the inventor can secure the amount of hydrogen intake in the body and conduct various clinical trials on the condition of the skin, which is an area of interest in the cosmetic field, as a target of a biological reaction by suction administration of hydrogen, which is easy to control the intake and time. A hydrogen suction device capable of repeatedly generating good results has been demonstrated and developed.

[Patent Document 1] International Publication No. WO2018/151107

Hayashi K. et al.: Inhalation of hydrogen gas reduces infact size in the rat model of myocardial Ischemia-reperfusion injuly. Biochem. Biophs. Res. Commun, 373:30-35, 2008.

Accordingly, the present invention relates to a hydrogen aspiration cosmetic method that can promote improvement of skin condition when a high concentration of hydrogen-containing gas air is ingested into the body by oral or nasal suction under natural breathing continuously for a predetermined time or more per one time, continuously for a predetermined period, and An object of the present invention is to provide a high-concentration hydrogen suction device having a configuration suitable for use in the hydrogen suction cosmetic method.

In order to solve the above problems, the first present invention provides a hydrogen aspiration cosmetic method that promotes improvement of skin condition non-therapeutically by routinely oral or nasal aspiration of a high-concentration hydrogen-containing gas generated from a hydrogen generating means. do.

As in the hydrogen suction cosmetic method of the first present invention, if a high concentration of hydrogen-containing gas air is routinely ingested into the body by oral or nasal suction under natural breathing, the improvement of the skin condition can be promoted. So far, improvements in living functions and cognitive functions when hydrogen is inhaled orally or nasally have been verified, but as will be described later, this time, as will be described later, if hydrogen-containing gas is inhaled commercially, such as by inhaling several times a day, the improvement of the skin condition is promoted. I get it. Here, the predetermined time per one time, which is a single time for hydrogen suction, means a suction time at which an approximately transient miotic reaction is recognized.

In addition, in this hydrogen suction cosmetic method, it is possible to promote improvement of skin condition by typically reducing redness and reducing the number of red spots and age spots. Specifically, there was a clear improvement in skin conditions, particularly red spots and age spots, by inhalation of a high-concentration hydrogen-containing gas (see FIGS. 9 and 10 ).

In addition, this hydrogen suction cosmetic method can promote improvement of the skin condition as the skin recovery rate and viscoelasticity increase. As described above, in addition to red spots and age spots, an increase in skin recovery rate (Uf=R2) and skin viscoelasticity (R7) was demonstrated as a remarkable improvement example by suction (continuous use) of a gas containing high concentration of hydrogen. This R2 is the ratio Ua/Uf of the height Ua returned from the skin height at the maximum extension after the release of the negative pressure to the maximum height Uf of the skin drawn into the probe of the instrument at the time of negative pressure, and the viscoelasticity of the skin R7 is high concentration hydrogen The instantaneous (instantaneous) contraction rate with respect to the stretched length of the skin upon suction of the contained gas = the elastic modulus upon contraction (R7 = Ur/Uf), and Ur/Uf is the displacement of the skin deformed at a constant suction pressure and time. It is the return elasticity ratio obtained by analysis.

In addition, in this hydrogen aspiration cosmetic method, oral or nasal suction of hydrogen-containing gas is preferably performed 5 times or more daily for 5 minutes or more at intervals of about 15 minutes or more, and continues for about 2 weeks or more.

For example, hydrogen suction can certainly promote the improvement of the skin condition by inhaling for 5 minutes or more 5 times a day or more and performing this continuously for about 2 weeks or more. This is because the skin condition of the subject who stopped high-concentration hydrogen gas suction for 2 weeks and the subject who newly performed high-concentration hydrogen gas suction for 2 weeks were reversed by the crossover test described later, at least about 5 minutes in which a transient miotic reaction was recognized As mentioned above, it is clear that the continuous suction of high-concentration hydrogen gas 5 times a day for 2 weeks promotes the improvement of the skin condition. It was also found that suction of high-concentration hydrogen gas-containing air at least 15 minutes apart, such as "when waking up, after breakfast, after lunch, after dinner, and before going to bed," is effective.

In addition, it is preferable that the hydrogen-containing gas to be sucked orally or nasally aspirated contains 1 to 2% of hydrogen.

Next, the second aspect of the present invention provides a high-concentration hydrogen suction device used in the above hydrogen suction cosmetic method,

Hydrogen generating means for generating and releasing hydrogen;

a hydrogen transfer means for guiding a high-concentration hydrogen-containing gas in which hydrogen and environmental air emitted from the hydrogen generating means are mixed to the nasolabial cavity of the human body;

and an attachment for orally or nasally aspirating a high-concentration hydrogen-containing gas from the hydrogen transfer means.

The second high-concentration hydrogen suction device of the present invention is an exclusive product used to improve skin condition, and is for orally or nasally suctioning high-concentration hydrogen gas-containing air. As described above in the first invention, when high-concentration hydrogen-containing air is routinely ingested into the body by oral or nasal suction under natural breathing, the improvement of the skin condition can be promoted, and this improvement can be appropriately achieved. Each characteristic structure is employed in the present high-concentration hydrogen suction device as a device of

First, in the present high-concentration hydrogen suction device, there is a hydrogen generating means for generating hydrogen and mixing the generated hydrogen and environmental air, so that a hydrogen-containing gas having an appropriate concentration for suction can be generated. The generated hydrogen-containing gas at an appropriate concentration is transferred to the acetabulum by a hydrogen transfer means, and can be introduced into the acetabulum through an attachment connectable to the acetabulum. Therefore, improvement of the skin condition can be promoted as in the following empirical example.

A specific example of the present high-concentration hydrogen suction device is a portable hydrogen suction assembly including the hydrogen generating means, the hydrogen transferring means, and the attachment,

The hydrogen generating means has an electrolyzer for generating hydrogen by electrolyzing the electrolyzed water by energizing the anode and the cathode spaced apart from each other in the electrolyzed water,

The hydrogen transfer means and the attachment are configured as an integrally coupled mixing unit for guiding a high-concentration hydrogen-containing gas in which hydrogen generated in the electrolyzer and environmental air are mixed to the acetabulum under negative pressure by oral suction or nasal suction.

This high-concentration hydrogen suction device is portable and employs an electrolysis type capable of reliably suctioning a desired amount of hydrogen by energizing as a hydrogen generation method. In order to improve the skin condition, for example, it is necessary to inhale high-concentration hydrogen-containing air commercially, for example, carried out 5 times or more daily for a predetermined time at intervals of about 15 minutes or more, and continuously for about 2 weeks or more, etc. It is essential to have portability because it can be easily used in any place, and it is desirable to have a high-concentration hydrogen suction device of this configuration in response to such a request. Furthermore, according to the present high-concentration hydrogen suction device, the hydrogen transport means for mixing hydrogen and environmental air for adjusting the concentration of hydrogen and the attachment for introducing the mixed air into the acetabulum are integrated, so that the negative pressure by normal suction can be adjusted to an appropriate concentration. Since the mixing part is provided, it is advantageous.

Furthermore, this high-concentration hydrogen suction device,

Oral or nasal suction is performed while holding a battery, a control board for controlling power supply from the battery, and a pair of positive and negative electrodes through which the positive and negative electrodes are energized or charged by the control board and held with one hand. Provided with a possible body cover member,

The electrolytic cell is mounted on the main body cover member, and the pair of positive and negative electrodes are inserted therein to be a transparent or translucent body capable of water storage,

The mixing unit is detachably mounted on the upper part of the electrolytic cell and has a nozzle unit for guiding hydrogen-containing gas air into the acetabulum, and a flow path for introducing environmental air from the electrolytic cell to the nozzle unit, and is integrally formed. composed,

Preferably, the control board controls supply and stop of power from the battery to the positive and negative electrodes by operation of one operating means disposed on the side of the main body cover member.

This high-concentration hydrogen suction device adopts a configuration that can be easily operated by any user with one operating means at least for hydrogen generation/stop operation by a hand holding the hand when hydrogen is suctioned, so that any user can use it easily. Furthermore, in the case of electrolysis-type hydrogen generation, bubbles of hydrogen and oxygen are generated in the electrolyzer, but when the electrolytic cell is made transparent or translucent, the cognitive function is lowered and the ability to continue one operation is lowered even by users who seem to have reduced ability to continue. The state can be known, and it can be easily recognized that good gas is being sucked. It is also advantageous in this respect (which can be easily recognized by caregivers, etc.).

According to the hydrogen aspiration cosmetic method of the present invention, improvement of the skin condition can be promoted by routinely orally or nasally suctioning under natural breathing, such as by inhaling high-concentration hydrogen-containing gas air several times a day, as in the hydrogen absorption cosmetic method. have.

The second high-concentration hydrogen suction device of the present invention is a device suitable for use in the hydrogen suction cosmetic method of the first invention, and generates hydrogen-containing gas at an appropriate concentration for suction and transports it to the acetabulum in order to promote improvement of the skin condition. can be introduced into

1 is a block diagram schematically showing an embodiment of a high-concentration hydrogen suction device of the present invention.
2 is a front view, a left and right side view, and a plan view showing an embodiment of the high-concentration hydrogen suction device of the present invention.
Fig. 3 is a schematic diagram showing the state of electrolysis in the electrolytic cell of the high-concentration hydrogen suction device of the present invention.
4 schematically shows a specific configuration of an electrode.
Fig. 5 is an external appearance photograph of an embodiment of the high-concentration hydrogen suction device of the present invention.
Fig. 6 is a diagram showing the change in the contraction rate according to the hydrogen suction time.
7 is a view showing a change in skin temperature in a peripheral region by skin temperature measurement.
8 is a view showing changes in skin viscoelasticity.
9 is a view showing changes in skin blemishes and age spots.
10 is a diagram showing the effect on the redness of the skin.

First, an example of the hydrogen aspiration cosmetic method (hereinafter also simply referred to as “the present hydrogen absorption cosmetic method”) for non-therapeutically promoting improvement of the skin condition of the first present invention and the results of the demonstration will be described below.

In the verification test using this hydrogen aspiration cosmetic method, hydrogen generated by a hydrogen generating device for health improvement (high-concentration hydrogen suction device (1) described later (Aquabank “Kencos3” (refer to FIGS. 1 to 5))) was orally aspirated. do. Specifically, hydrogen generated by the high-concentration hydrogen suction device 1 was sucked under natural respiration. In addition, in this high-concentration hydrogen suction device, 8 cc of hydrogen gas is generated per minute (4 cc of oxygen gas is also generated) by electrolysis of water by the electrolysis method described later. As a result, 12 cc of oxygen and water are mixed in 1 minute. gas is generated. Also, in general, in natural respiration, it is assumed that all of the mixed gas generated by inhaling about 5 liters of air per minute for an adult is inhaled, and in theory, the mixed gas is maximally 0.24% (hydrogen: hydrogen: 0.18%, oxygen: 0.06%) during exhalation. ) was calculated to be included. In addition, the hydrogen gas to be inhaled was adjusted for each subject, and the high-concentration hydrogen suction device used once was not reused. In addition, in order to calculate the optimal amount of hydrogen aspiration, the pupil-to-light response was measured for 1 min, 3 min, 5 min, 7 min, and 9 min suction. As a result, the pupil-to-light reaction contraction rate by hydrogen absorption was increased in a time-dependent manner preferentially (FIG. 6). It was found that the contraction rate increased significantly after hydrogen inhalation for 3 minutes, and the effect was stabilized after 7 minutes of inhalation. From this, it was decided to examine the physiological response when hydrogen was inhaled for 5 minutes in subsequent tests.

In addition, each concentration increase of the mixed gas of hydrogen and oxygen generated from the high-concentration hydrogen suction device 1 is 0.18% of hydrogen and 0.06% of oxygen, as described above, while each concentration in the atmosphere is 0.5×10 ^-4 % of hydrogen (= 0.5 ppm), about 21% oxygen. Therefore, the increase in the oxygen concentration in the mixed gas is very small, and the result of the verification can be regarded as the cause of the increase in the hydrogen concentration in general.

In a single evaluation test of hydrogen inhalation, 17 healthy women aged 25-40 years were the subjects. The selection criteria were good health and non-smokers. After entering the test room set at room temperature 24°C and 50% relative humidity, the subject was stabilized in a sitting position for 30 minutes to acclimatize to the experimental environment. After acclimatization, physiological measurements were performed. As a physiological measurement, skin temperature measurement was performed. This measurement was performed under natural breathing (presenting a control) and hydrogen inhalation for 5 minutes (presenting a sample), and the measurement results were interpreted. And by comparing and examining the measured values, the physiological effect of hydrogen gas inhalation was verified.

«Evaluation of pupil-to-photoreaction constriction by pupil-to-photoreaction measurement (single evaluation test (Fig. 6))»

Regarding the pupil-to-light reaction shrinkage ratio (FIG. 6) by the pupil-to-photoreaction measurement that evaluated the appropriate hydrogen gas suction time described above, as a measurement method, an electron pupil system similar to goggles (Iris Coder Dual, Hamamatsu Photonics) was used as a measurement method. It was placed on the face and dark-adapted for 5 minutes in a state of blocking light. After confirming that the mydriasis of the pupil was stable, photostimulation was performed for 0.1 second. A transient miotic response of the pupil was observed by pupil-to-light reflection. The amount of change in the initial state pupil diameter D1 before photostimulation and the pupil diameter D2 after photostimulation in suction for 5 minutes of control (air) and 5 minutes of sample (hydrogen aspiration) is defined as D1-D2, and the contraction rate (CR) ) was calculated as (D1-D2)/D1. In addition, the pupil dilates rapidly after miosis, but the mydriatic velocity (vd) at that time reflects the state of sympathetic nerve activity. By analyzing the change in the pupil diameter, the superiority of the sympathetic nerve activity and the parasympathetic nerve activity in the autonomic nerve activity was judged. From FIG. 6 , it can be seen that the contraction rate CR significantly increased after hydrogen suction, especially after suction for 5 minutes or more (p<.001). On the other hand, the mydriatic velocity vd hardly changed (not shown).

≪Evaluation of sympathetic nerve activity by skin temperature measurement ((single evaluation test (Fig. 7))≫

Since most of the peripheral vascular network is dominated by sympathetic nerve activity, the superiority and inferiority of sympathetic activity can be evaluated by measuring changes in blood flow in the peripheral region or changes in skin temperature in the peripheral region. was done with That is, the change in the skin temperature (center of the forehead and the bottom of the first joint of the index finger) in the peripheral region was measured by a temperature sensor (Gram Corporation). The center of the forehead of the control was H1, the center of the bottom of the finger was F1, the center of the forehead of the sample was H2, and the center of the bottom of the finger was F2. For example, if a significant increase in skin temperature is observed by hydrogen inhalation, it is presumed that the sympathetic nerve activity is decreased by hydrogen inhalation. As a result of the test, as shown in FIG. 7 , almost no change was observed in the skin temperature of the forehead by hydrogen suction, but it was recognized that the skin temperature of the index finger significantly increased by an average of 3.6°C (p<.001). In some subjects, the skin temperature of the index finger increased by 6°C or more due to hydrogen suction.

In addition, the analysis of the measured data in the physiological evaluation was compared using the t-test by matching the difference between the control and the blank and the difference between the test article and the blank. The significance level of the t-test was set to less than 5%.

In the continuous use evaluation trial of hydrogen inhalation, the subjects were 22 healthy women between the ages of 25 and 40 who lived in and around Tokyo. Subject selection conditions include good health and no smoking, skin condition worsening due to stress or fatigue, for example, lack of elasticity, awareness of sagging, and feeling dull, and 30 items on a simple stress checklist was assumed to be in a state of mild stress corresponding to a stress level of 6 to 10. During the trial period, each subject was asked to carry out the daily skin care method and not to add or change cosmetics or supplements.

In this verification test, the effect of improving skin properties was confirmed by using the high-concentration hydrogen suction device 1 and continuously using the suction of hydrogen gas. The test period was a total of 4 weeks of continuous use of the high-concentration hydrogen suction device 1 for 2 weeks and non-use for 2 weeks, and comparative evaluation was performed between the non-use period and the hydrogen use period. That is, 11 subjects were divided into two groups, group A and group B, respectively. Group A set the first 2 weeks as the hydrogen use period and the next 2 weeks as the non-use period, whereas Group B set the first 2 weeks as the non-use period and the next 2 weeks as the hydrogen use period. Skin physiological measurements were performed at the start of the test (week zero), at the second week, and further at the fourth week (though omitted here, in reality, the 30 items of the stress checklist and the multi-faceted emotional scale questionnaire were also answered, so that the factors for promoting skin metabolism The effect of stress was also verified). As measurement items, stratum corneum water content, transdermal water evaporation, skin viscoelasticity, skin color, facial image analysis by imaging with a digital imaging device (VSIA), and skin blood flow measurement using a non-contact blood flow meter were performed. In the second and fourth weeks of the test, responses to the psychological questionnaires and skin physiology measurements were performed, and the psychological and physiological effects of hydrogen suction were verified by comparing and examining each measured value.

Here, in the hydrogen suction continuous use test, the high-concentration hydrogen suction device 1 was used similarly to the single test described above. Subjects were subjected to aspiration for 5 minutes per one time as in the single test with an interval of about 1 hour between morning and evening and after each meal, aiming to use 5 times per day.

The physiological measurement of the skin was performed by measuring the amount of moisture in each layer, the amount of transdermal water evaporation, skin viscoelasticity, skin color, image analysis of the face by imaging with a digital imaging device (VISIA), and measurement of skin blood flow using a non-contact blood flow meter. These skin physiology measurements were performed at week zero, week 2, and week 4, and each measurement value was compared and reviewed to verify the skin physiology effect of hydrogen inhalation. In the measurement listed below, after washing the face, after acclimatization for 15 minutes in a constant temperature and humidity room (temperature 20±2° C., humidity 50±10%), measurement of the cheek part as the measurement site was performed. The contents of each measurement are described below.

≪Measurement of keratin moisture content and transdermal moisture evaporation (TEWL) (continuous use evaluation test)≫

By measuring the amount of moisture in each layer, the degree of moisture in the skin was determined. The moisture content of each layer of the measurement site was measured using SKICON-200EX (Yayoi Co., Ltd.). The measurement was performed 5 times in the ball part, and the average value of three measurements in which the highest value and the lowest value were omitted was made into a measured value. Measurements were made at week zero, at week 2 and at week 4. Moreover, the degree of the barrier ability of skin was judged by measuring the amount of percutaneous moisture evaporation. The TEWL of the measurement site was measured using a cyclone water evaporator AS-CT1 (Asahi Biomed Co., Ltd.). The measurement was performed 5 times in the ball part, and the average value of three measurements in which the highest value and the lowest value were omitted was made into a measured value. Measurements were made at week zero, at week 2 and at week 4.

Although not shown, as a result of the test, an increase in the amount of skin moisture was recognized in the period of continuous hydrogen use (average differential value; +34.9 μS), and almost no increase in moisture content was recognized in the period of non-continuous use (average differential value; +6.5 μS), There was no significant difference. As a result, it was assumed that the original subject's skin moisture content was high and the skin had sufficient moisture, so that no significant change could be seen. In addition, a decrease in the amount of transdermal water evaporation was recognized in the period of continuous hydrogen use (average differential value; +34.9), and an increase in moisture content was hardly recognized in the period of non-continuous use (average difference value; +6.5), but there was no significant difference. As for this result, it was estimated that the change was not recognized because the barrier function of the skin was sufficiently maintained rather than the amount of percutaneous water evaporation of the original subject was low.

≪Measurement of skin viscoelasticity (continuous use evaluation test (Fig. 8))≫

By measuring the viscoelasticity of the skin, the elasticity of the skin and the degree of sagging were determined. The skin viscoelasticity of the measurement site was measured using a cutometer MPA580 (C+K electronic GmbH.). In addition, since the dry state of each layer affects the measured value, a small amount of a commercially available cream formulation was applied to the measurement site about 15 minutes before the measurement to exclude the effect of dryness and moisture in each layer. The measurement was performed 5 times in the ball part, and the average value of three measurements in which the highest value and the lowest value were omitted was made into a measured value. Measurements were made at week zero, at week 2 and at week 4.

As parameters of skin viscoelasticity, R2=Ua/Uf, R6=Uv/Ue, and R7=Ur/Uf were analyzed. In addition, Uf represents the maximum height of the skin drawn into the probe at the time of negative pressure, and Ua represents the height returned from the skin height at the time of maximum extension after the negative pressure is released. Ua/Uf represents the rate of skin recovery. Ue (immediate distension) is an increase in skin height that rises linearly when negative pressure is applied, and Uv (delayed distension) is a non-linear increase in skin height that can be seen following Ue. It is considered that Ue reflects the elasticity of the skin, Uv mainly reflects the viscosity of the skin, and Uv/Ue indicates the degree of viscosity that contributes to the change of the skin. In addition, Ur (immediate retraction)/Uf is considered to represent biological elasticity. It was suggested that when skin elasticity increased, R2 value increased, R6 value decreased, and R7 value increased.

As shown in FIG. 8 , as a result of the test, the average difference value of the instantaneous skin recovery rate R7 (Ur/Uf) value was 0.01 in the hydrogen continuous use period, whereas it was -0.01 in the hydrogen non-use period. The p value was 0.028, which was statistically significant, and the effective amount was 0.74, indicating a moderate effect. Furthermore, in the hydrogen use period, the average difference value of the skin recovery rate R2 value was 0.01, whereas in the hydrogen non-use period, it was -0.02. The p-value was 0.076, and there was no statistically significant difference, but the effective amount was 0.59, indicating a moderate effect, indicating that there was a significant trend due to continued use of hydrogen. Since it shows that the instantaneous recovery power of the skin and an increase in the skin recovery rate are recognized by the continuous use of hydrogen suction, it seems to suggest the recovery of skin elasticity and improvement of sagging.

≪Measurement of skin color (continuous use evaluation test)≫

The skin color of the measurement site was measured using a handy color difference meter NR555 (Nippon Denshoku Industrial Co., Ltd.). The measurement was performed 7 times in the ball part, and the average value of 5 measurements in which the highest value and the lowest value were omitted was made into a measured value. Measurements were made at week zero, at week 2 and at week 4.

Although not shown, the results of the test were analyzed by dividing the skin color of the measurement site into three factors (L*, a*, b*). In other words, it was analyzed by dividing the skin into black and white; L*, the degree of redness; a*, the degree of yellowishness; and b*. As a result, in the period of continuous hydrogen use, the average difference value of each factor was (Δ; +0.30, Δa*; -0.23, Δ; -0.20), but in the period of non-sustainable use, (Δ; -0.22, Δa*; -0.45) , Δb*; -0.01), suggesting that there is a tendency to improve skin color with whitening, reduction of redness, and reduction of yellowness due to continuous use of hydrogen, but there was no significant difference.

« Analysis of skin condition by VISIA (registered trademark)-Evolution (continuous use evaluation test (FIGS. 9 and 10))»

A skin image of the measurement site was taken using VISIA (registered trademark) Evolution (Canfield Imaging Systems), and the skin properties were analyzed. The scores of pores, blemishes, wrinkles, skin texture, redness, porphyrin, and age spots were measured using the software included with the device. Measurements were made at week zero, at week 2 and at week 4.

As a result of the test, pores, blemishes, wrinkles, skin texture, redness, porphyrin, and age spots were analyzed as skin conditions by VISIA (registered trademark). Among these factors, no difference was recognized in the measured values of pores, wrinkles, and skin texture in the period of continuous and non-sustaining use of hydrogen (results not shown). In addition, the number of porphyrins decreased in the period of continuous hydrogen use (average difference; -103.05) compared with the period of non-continuous use (average difference; +190.68), but it was not significant.

In addition, in the analysis of skin blemishes, VISIA (registered trademark) detects stains present in the skin surface layer derived from excess melanin (via the VISIA Evolution operation manual). Therefore, it is considered as an indicator that the skin color is uniform as the measured values of the analyzed spots and age spots are smaller, respectively. Accordingly, the analysis of stains showed that the average value of the difference in the number of stains in the period of continuous hydrogen use was -1.8, whereas the average value of the number of stains was 4.7 in the period of not using hydrogen. The p value was 0.0012, which was statistically significant, and the effective amount was 0.86, indicating a large effect. Also, in the analysis of age spots, the average value of the difference in the number of age spots in the period of continuous hydrogen use was -13.7, whereas it was 3.8 in the period of not using hydrogen. The p value was 0.046, which was statistically significant, and the effective amount was 0.68, indicating a moderate effect. These results are shown in FIG. 9 .

On the other hand, in the analysis of the redness of skin color, the average value of the difference in redness in the period of continuous hydrogen use was -5.1, whereas it was 3.2 in the period of non-sustaining use. The p value was 0.042, which was statistically significant, and the effective amount was 0.65, indicating a moderate effect. The results are shown in Fig. 10(a). In addition, the VISIA image is shown in FIG. 10(b) as an effective example of the reduction of redness by continuous use of hydrogen for 2 weeks. The results of skin color measurement and VISIA image analysis suggest that the continuous use of hydrogen suggests a reduction in facial skin redness and a significant reduction in the number of blemishes and age spots. appeared to have contributed.

≪Measurement of skin blood flow (continuous use evaluation test)≫

The skin blood flow at the measurement site was measured using a two-dimensional laser blood flow imaging device (OMEGAZONE OZ-2, Omega Wave Co., Ltd.). The measurement site was the entire face. After 1 minute of stabilization, the measurement was performed for 30 seconds, and the average value during that time was used as the measurement value. Measurements were made at week zero, at week 2 and at week 4.

Although not shown, as a result of the test, the change in skin blood flow throughout the face was analyzed using a two-dimensional laser blood flow imaging device. The average value of the difference was -0.53, indicating that the decrease in skin blood flow was suppressed by continuous use of hydrogen, but it was not a significant difference.

In addition, data analysis calculates a difference value (Δ value) from the measured values before and after the hydrogen use period and non-use period of the subject in each group, and adds the difference values of the subjects in each hydrogen use period group or non-use period group The value calculated by the average was taken as the average difference value of the hydrogen use period group and the difference average value of the non-use period group.

The calculation formula of the difference average value is as follows.

Average difference value of hydrogen use period group: AΔ(2W - 0W) + BΔ (4W- 2W)

Average difference value of unused period group: AΔ(4W - 2W) + BΔ(2W - 0W)

The p-value was calculated as the probability of whether there was a statistically significant difference in the mean difference value of each group, and the effective amount was calculated as an index indicating the size of the difference in the mean difference value, and the comparison between the two groups was performed.

≪Example of high-concentration hydrogen suction device≫

Next, a representative embodiment of the second present invention as a hydrogen generating device recommended for performing the living body improvement method for improving the living function and/or detection function of the first present invention will be described with reference to Figs. It will be described in detail below. However, it cannot be overemphasized that the present high-concentration hydrogen suction device 100 is not limited to those shown in FIGS. 1 to 5 .

Hereinafter, an embodiment of the present high-concentration hydrogen suction device 1 will be described by way of example. Fig. 1 is a block diagram schematically showing the embodiment, Fig. 2 is a hexahedral view of a representative example of the embodiment of Fig. 1, and Fig. 4 is a schematic schematic diagram showing the state of electrolysis in the electrolyzer of the high-concentration hydrogen suction device. has been 5 schematically shows a specific configuration of an electrode. In addition, it goes without saying that the high-concentration hydrogen suction device 1 of the present invention is not limited to the one shown, and also includes those in which the contents of the illustration and description are modified within the scope of common sense.

As shown in Fig. 1, the present high-concentration hydrogen suction device includes a battery (4), an LED (16), a control means (17), an electrolyzer (3), a fragrance or a supplement cartridge (hereinafter also referred to simply as “cartridge”) ( 5), the mixing part 2 and the nozzle part 8 are substantially comprised. First, the battery 4 is a rechargeable type, and a pair of positive and negative electrodes 6 and 7 are arranged in the electrolytic cell 3 . The positive and negative electrodes 6 and 7 are supplied with electric power from the battery 4 through the control means 33 , and the LED 16 is connected to the battery 4 . The control means 17 is equipped with the electrode control circuit 17a, the heater control circuit 17b, the LED control circuit 17c, and the electric power supply means (power supply circuit) 17d.

In addition, a pressure sensor switch 19 is provided at the bottom of the accommodating part of the cartridge 5, and when the lower end of the cartridge presses the pressure sensor switch 19, the power supply means 17d of the control board 17 activates the battery 4 Power is supplied to the cartridge 5 .

In addition, when the user operates the operation button 18, the electrode control circuit 17d controls the energization/disconnection of the pair of electrodes 6 and 7 in the electrolytic cell 3 according to this, and the electric power supply means 17d. By varying the amount of electric power supplied from the battery 4, electric power is supplied to the electrodes 6 and 7 . When power is supplied to the pair of electrodes 6 and 7, water stored in the electrolyzer 10 is electrolyzed to generate oxygen at the positive electrode 6 side and hydrogen at the negative electrode 7 side.

Hydrogen generated from the negative electrode 7 flows into the lid member 2 through the attachment 14 on the top of the electrolytic cell 3 . Also, oxygen generated from the positive electrode 6 is vented.

Also, in the cartridge 5, when the pressure sensor switch 19 is turned on, the electric power to the heater in the cartridge 5 is supplied from the battery 4 by the electric power supply means 17d, and an internal vapor chamber (not shown) is supplied. The cartridge in which the fragrance ingredient or supplement having the effect of promoting health and beauty is adsorbed is heated. When a cartridge that has adsorbed supplements (including pharmaceuticals) or fragrance ingredients (hereinafter simply referred to as “supplements”) is heated by a heater, supplement-containing vapors are generated.

The supplement-containing vapor generated in the cartridge (5) is discharged into the mouth by sucking the nozzle (8). At this time, due to the negative pressure generated by the suction, the hydrogen emitted from the attachment 4 flows through the lid member 2, and the periphery of the upper part of the cartridge 5 exposed in the lid member 2 and the nozzle part 8 It passes through a gap with the inner wall, mixes with the supplement-containing air, and is guided into the mouth. It is also conceivable to generate a supplement-containing vapor by heating this.

2 shows a specific configuration example of the present high-concentration hydrogen suction device 1 . Fig. 2 (a) is a front view of the high-concentration hydrogen suction device 1, (b) is a plan view, (c) is a left view, (d) is a right view. (a) is a state in which the lid member 2 of the high-concentration hydrogen suction device 1 is removed, and in a state in which the lid member 2 is removed (opened), a cylindrical cartridge receiving portion extending downward from the upper right opening. (hereinafter also referred to as "accommodating part") (20). The cartridge 5 is inserted into this receiving portion 20 . The cartridge 5 is a replacement part for the body part of the general-purpose cylindrical heated electronic cigarette.

The cartridge 5 is in the ON state when negative pressure is generated by sucking the upper part, and when the main power to be described later is ON, power is supplied from the rechargeable battery in the battery 30 and the vapor chamber is heated by the heater to release the supplement or fragrance component do. In addition, the cartridge 5 sucks the upper end to apply a negative pressure, and while power from the battery 30 is being supplied, the LED 30b at the lower end of the battery 30 is turned on.

Here, returning to FIG. 2 again, the present high-concentration hydrogen suction device 1 will be described. A cartridge 5 is inserted into the accommodating portion 20 of the high-concentration hydrogen suction device 1 . A pressure sensor switch 19 is disposed at the bottom of the accommodating portion 20 , and a convex screw 19a having the same shape as the attachment 30a is provided at an upper end thereof as an electrical terminal. When the pressure sensor switch 19 is pressed, electric power from the rechargeable battery (lithium battery) 4 is supplied to the convex screw 19a, and the supplement-containing vapor can be sucked.

Further, a cartridge ON/OFF switch 16c, an LED indicator 16b, and a main power/hydrogen button 16a are provided on the right side of the high-concentration hydrogen suction device 1 (see Fig. 2(c)). The cartridge ON/OFF switch 16c is the ON/OFF switch of the pressure sensor switch 19. When ON, the attachment 5a at the bottom of the cartridge 5 is connected to the convex screw 19 and pressed when pressed. It is in a state in which electric power is supplied to the rechargeable battery 4 to the furnace, and when the pressure sensor switch 19 is pressed, it is in a state in which electric power is not supplied from the rechargeable battery 4 . In addition, the main power/hydrogen button 16a is a button-type power supply switch between the anodes 6 and 7 and the main power in the electrolytic cell 3 to be described later, and the ON/OFF of the main power and the cathode 6 , 7) for power supply ON/OFF.

In this example, when the main power/hydrogen button 16a is pressed for 3 seconds, the anodes 6 and 7 are energized for 5 minutes to generate hydrogen, and when the main power/hydrogen button 16a is pressed for 2 seconds, the main power is turned off. In addition, the main power is automatically turned off after 20 minutes without turning off. In addition, the main power/hydrogen button 16a lights up during hydrogen generation, and has a function of displaying the remaining amount of the rechargeable battery 4 according to its lighting color. In this example, when the remaining battery power is 20 to 80%, the light is blue, and when the remaining battery power is 80 to 100%, the light is white. In addition, the LED indicator 16b is provided with two upper and lower LEDs, the upper LED lights when power is supplied to the positive and negative electrodes 6 and 7 in the electrolytic cell 3, and the lower LED is the pressure sensor switch 19 It turns on and lights when electricity is supplied to the cartridge (5). In addition, lighting of each of the electronic cigarette ON/OFF switch 16c, the LED indicator 16b, and the main power/hydrogen button 16 is controlled by the indicator board 26 inside.

As described above, when the pressure sensor switch 19 is turned on, power from the rechargeable battery 4 is also supplied to the pair of positive and negative electrodes 6 and 7 by the control board 17 . As shown in FIG. 2( c ), the pair of positive and negative electrodes 6 and 7 may be disposed in the transverse direction on the inner bottom of the electrolytic cell 5 , or may be disposed in the vertical direction as shown in FIG. 1 . In addition, the rechargeable battery 4 is charged by receiving power through the USB terminal 16d on the side of the high-concentration hydrogen suction device 1 (see FIG. 2(d)).

Next, the configuration in the electrolytic cell 3 and the state of electrolysis in the electrolytic cell 3 when the positive and negative electrodes 6 and 7 are energized will be described with reference to FIG. 3 . As shown in Fig. 3, the stored electrolytic cell 3 is approximately hollow and includes a cylindrical member 3b extending in the longitudinal direction, a bottom member 3a for closing the bottom of the cylindrical member 3b, and a cylindrical member ( and lid members 3c and 3d (3c and 3d may be integrally molded), which close the upper part of 3a). When the positive and negative electrodes 6 and 7 are energized, oxygen (O _{2 ) is generated in the vicinity of the positive electrode 6 , and hydrogen (H 2} ) is generated in the vicinity of the negative electrode 7 . The generated oxygen and hydrogen have a lighter specific gravity than water, so they move upward and move into a gap (3g), respectively. Here, the electrolytic cell 3 extends downward from its upper end to divide the electrolytic cell 3 into a hydrogen gas generating layer 12 on the negative electrode 7 side and an oxygen gas generating layer 13 on the positive electrode 6 side. A member 8 is provided. The lower end of the partition member 8 is provided with a gap 3g from the upper surface of the bottom member 3a so as to fluidly connect the hydrogen gas generating layer 12 and the oxygen gas generating layer 13 .

Mixing of oxygen and hydrogen in the electrolytic cell 3 is inhibited by this partition member 8 when oxygen and hydrogen move upward. On the other hand, in the lower part of the gap 3g provided under the partition plate 8 that is not partitioned by the partition member 8, _{free movement of water (H 2} O), that is, ions required for the generation of oxygen and hydrogen (“ OH ^- ” and “H ⁺ ”) movement is possible. In this way, inhibition of mixing of oxygen and hydrogen is achieved while electrolysis is performed by the partition member 50 .

The lid member 3c closes the upper part of the oxygen gas generating layer 13, but is a part of the lid member 3c or an opening 3e between the lid member 3c and the partition member 8 or the cylinder member 3b. ) is being prepared. The opening 3e is closed with an oxygen permeable membrane 9 . Therefore, even if hydrogen leaks from the hydrogen gas generating layer 12 to the oxygen gas generating layer 13 due to the gap 3g or the like, the gas emitted to the outside by the oxygen permeable membrane 9 is limited to only oxygen. The oxygen permeable membrane 9 may be disposed at the electrolyte injection port/hydrogen generating port 14 (to be described later) shown in FIG. 2 , but is preferably disposed in a dedicated hole in the electrolytic cell 3 .

Also in the case of the hydrogen gas generating layer 12, the upper portion of the hydrogen gas generating layer 12 is closed by the lid member 3d, but an opening ( 3f) is provided. The opening 3f is connected to the bypass flow path 3h. Accordingly, hydrogen in the hydrogen gas generating layer 12 generated by the negative electrode 7 flows into the bypass flow path 3h and flows upward.

With respect to the hydrogen flow path of the opening 3f to the bypass flow path 3h in FIG. 3 , in the example of FIG. 2 , the electrolyte injection port/hydrogen generating port 14 is the opening 3f, the upper part of the electrolytic cell 3 and the lid member ( The gap between 2) corresponds to the bypass flow path 3h. The electrolyte injection port/hydrogen generating port 14 has a function as an inlet for injecting electrolyte or water into the electrolytic cell 5 as described above, and an opening 3f for discharging hydrogen in the electrolytic cell 5 to the outside. . It has a shape that can be detachably screwed to the electrolyte injection port/hydrogen generating port 14, and the electrolyte or water is injected through the opening 3f in a state in which the screw is loosened and separated. In addition, in the state in which the screw is tightened, the leakage of electrolyte in the electrolytic cell 5 is suppressed, but hydrogen is supplied through a gas permeable membrane (not shown) such as hydrogen that blocks a hole provided separately in the electrolyte inlet/hydrogen generating port 14 emit

The released hydrogen flows in the left direction (cartridge 5 direction) in the lid member 2 as indicated by the dotted line in FIG. 2 . The lid member 2 has an opening at the left end and a protruding tubular nozzle portion 2a at the upper end, and covers the upper end of the cartridge 5 and the electrolyte inlet/hydrogen generating port 14 to cover the electrolytic cell (5) It is a detachable integral member disposed on top of. When the lid member 2 is mounted on the upper part of the electrolytic cell 3, the nozzle part 2a enters into its opening into a nested state with the upper end of the cartridge 5 providing a gap 26 around it. When the nozzle part 2a is sucked, hydrogen (high-concentration hydrogen-containing air) flowing from the electrolyte injection port/hydrogen generating port 14 rises through the gap 26 and is discharged to the outside (refer to the dotted line in FIG. 2 ). Thereby, high-concentration hydrogen can be ingested. In addition, when electric power is supplied to the cartridge 5, a mixed gas of a supplement and/or a fragrance component having a health/beauty promoting effect and a mixed gas of high concentration hydrogen can be ingested. In addition, this high concentration hydrogen suction device 1 is provided with the cover 1a which can be opened and closed, and the state in which the cover 1a is opened is shown in the example of FIG. In addition, an opening (electrolyte solution confirmation window) 3i is provided on the side of the high-concentration hydrogen suction device 1 to see the amount of liquid in the electrolytic cell 5 so that the liquid amount in the electrolytic cell 3 can be visually recognized.

For reference, FIG. 5 is an external appearance photograph of an embodiment of the high-concentration hydrogen suction device 1 of the present invention. Fig. 5 (a) is a view of the high-concentration hydrogen suction device 1 from the left oblique front, (b) is a right-side oblique front view of the high-concentration hydrogen suction device 1, and (c) is a left oblique view of (a). The state in which the cover 1a of the high concentration hydrogen suction apparatus 1 seen from the front is opened is shown. Although there are parts different from the example of FIG. 2 in design, the main structure is substantially the same, and reference numerals given to FIG. 5 are the same as those of the example of FIG. 2 .

In the above, the embodiments of the hydrogen suction cosmetic method of the present invention and the second high concentration hydrogen suction device of the present invention suitable for carrying out the hydrogen suction cosmetic method have been exemplified and described, but the present invention is not limited thereto, It will be understood by those skilled in the art that other modifications and improvements can be obtained without departing from the spirit or teaching of the claims and specifications.

[Industrial Applicability]

According to the hydrogen aspiration cosmetic method that promotes non-therapeutic improvement of the skin condition of the present invention and a high-concentration hydrogen suction device suitable for carrying out the hydrogen suction cosmetic method, by continuously orally or nasally inhaling high-concentration hydrogen-containing gas air in daily life, It is possible to promote the improvement of the skin condition, to provide a new skin condition improvement method to the beauty industry, and to contribute to the expansion of the beauty market by providing an appropriate device used therefor.

1: High-concentration hydrogen suction device
2: No lid
3: Electrolyzer
4: Rechargeable battery
5: Cartridge
6: positive electrode
7: negative electrode
8: nozzle part
17: control means
18: operation button (operation means)
19: pressure sensor switch
19a: convex screw
20: accommodating part for cartridge
25: cartridge adsorbed with the supplement

Claims (8)

A hydrogen inhalation cosmetic method that non-therapeutically promotes improvement of skin condition by routinely orally or nasally aspirating a high-concentration hydrogen-containing gas generated from a hydrogen generating means for a predetermined period of time or more at a time for a predetermined period of time. According to claim 1,
Hydrogen suction cosmetic method that promotes improvement of skin condition by reducing redness and reducing the number of red spots and age spots. According to claim 1,
A hydrogen suction cosmetic method that promotes improvement of skin condition by increasing skin recovery rate and viscoelasticity. According to any one of claims 1 to 3,
A hydrogen aspiration cosmetic method, wherein oral or nasal aspiration of hydrogen-containing gas is performed at intervals of about 15 minutes or more, 5 minutes or more per time, 5 times or more every day, and continued for about 2 weeks or more. According to any one of claims 1 to 4,
Hydrogen-containing gas that is orally or nasally aspirated is a hydrogen aspiration cosmetic method that contains 1 to 2% hydrogen. A high-concentration hydrogen suction device used for the hydrogen suction cosmetic method according to any one of claims 1 to 5,
Hydrogen generating means for generating and releasing hydrogen;
a hydrogen transport means for guiding a high-concentration hydrogen-containing gas in which hydrogen emitted from the hydrogen generating means and environmental air are mixed to the acetabulum of the human body;
and an attachment for orally or nasally aspirating a high-concentration hydrogen-containing gas from the hydrogen transfer means. 7. The method of claim 6,
A portable hydrogen suction assembly comprising the hydrogen generating means, the hydrogen transferring means, and the attachment,
The hydrogen generating means has an electrolyzer for generating hydrogen by electrolyzing the electrolyzed water by energizing the anode and the cathode spaced apart from each other in the electrolyzed water,
The hydrogen conveying means and the attachment are configured as an integrally coupled mixing unit for guiding a high-concentration hydrogen-containing gas in which hydrogen generated in the electrolyzer and environmental air are mixed with negative pressure by oral suction or nasal suction to the acetabulum, high-concentration hydrogen suction device. 9. The method of claim 8,
Oral or nasal suction is performed while holding a battery, a control board for controlling power supply from the battery, and a pair of positive and negative electrodes through which the positive and negative electrodes are energized or charged by the control board and held with one hand. Provided with a possible body cover member,
The electrolytic cell is mounted on the main body cover member, and the pair of positive and negative electrodes are inserted therein to be a transparent or translucent body capable of water storage,
The mixing unit is detachably mounted on the upper part of the electrolytic cell, and has a nozzle unit for guiding hydrogen-containing gas air into the acetabulum, and a flow path for introducing environmental air from the electrolytic cell to the nozzle unit, and is integrally formed. composed,
and the control board controls supply and stop of electric power from the battery to the positive and negative electrodes by operation of one operating means disposed on the side of the main body cover member.

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