KR20210115310A - Skin protection composition for protecting skin from cytotoxicity caused by fine dust - Google Patents

Abstract

The present invention relates to a skin protection composition for protecting the skin from cytotoxicity caused by fine dust, and more particularly, to a skin protection composition which contains a fermented colostrum product as an active ingredient, so as to protect the skin from air polluted with heavy metals or fine dust such as heavy metal-containing fine dust and ultrafine dust and prevent skin diseases. The skin protection composition of the present invention provides excellent efficacy in protecting the skin from skin damage or cancer caused by heavy metal cytotoxicity of the skin due to fine dust containing heavy metals, and thus can be useful as a composition for enhancing skin beauty, a cosmetic composition, a pharmaceutical composition for the epidermis, skin cleanser, etc.

Description

{Skin protection composition for protecting skin from cytotoxicity caused by fine dust}

The present invention relates to a composition for skin protection for protecting the skin from cytotoxicity caused by fine dust, and more particularly, to a composition containing a fermented colostrum as an active ingredient. It relates to a composition for skin protection that can protect the human body from cytotoxicity and cancer caused by fine dust such as dust and prevent diseases.

Recently, the concentration of fine dust flowing in from China and Mongolia is increasing, raising concerns about skin health. The concentration of fine dust on the Korean Peninsula is increasing due to the effects of yellow dust in spring, soot from China, exhaust gas from automobiles, and aging thermal power plants. Therefore, consumers are more interested in issues that directly touch the skin than any other issues.

In particular, particulate matter (PM), which causes skin irritation, is classified into PM10 with a diameter of 10 μm or less and PM2.5 with a diameter of 2.5 μm or less depending on the particle size. These PMs are the most toxic of all air pollutants. Depending on the size, structure and composition of these PMs, their toxicity varies. Toxic hitch hikers composing PM include heavy metals such as arsenic, lead, and cadmium, and substances such as sulfuric acid or polycyclic aromatic hydrocarbons produced during combustion. Polycyclic aromatic hydrocarbons are compounds linked by several benzene rings and are well known as carcinogenic and mutagenic substances.

It is reported that prostaglandin (PG) is involved in the development and progression of various human cancers such as gastric cancer, breast cancer, and lung cancer by affecting cell division or proliferation through physiological roles such as inflammation transmission, cell adhesion, and maintenance of the immune monitoring system. (Bennett A. Prog Lipid Res., 25: 539-542 (1986), Marnett LJ. Cancer Res., 52: 6675-5589 (1992)). In particular, there is a report that prostaglandin E2 (PGE2) is abnormally increased in various cancer tissues. In a carcinogenesis model, large amounts of PGE2 and PGF2 were observed in cancer induced by topical treatment of 7,12-dimethylbenz [a]anthracence, a carcinogen, in mouse skin (Miyauchi-Hashimoto H. et al., J Immunol,. 166: 5782-5791 (2001)).

However, it is difficult to find special ingredients that can protect the skin from fine dust such as pollutants in the air environment or air containing heavy metals.

Cow's colostrum (milk collected within 72 hours from the moment the mother gives birth) contains immunoglobulins, growth factors, lactoferrin, lysozyme, PRP (proline-rich polypeptide) that strengthens the immune system, and cell regeneration. It contains about 50 physiologically active ingredients essential for life maintenance, such as EGF (epithelial growth factor) and PDGF (platelet derived growth factor), and it also contains 12 kinds of amino acids including Cysteine, Glutamic acid, Lysine, Leucine, and Proline. (Seokgeun Jeong et al. Korean J. Food Sci. Ani. Resour. 29(4): 457-467(2009)).

Korean Patent No. 10-0964831 proposes a cosmetic composition for promoting keratin differentiation containing colostrum as an active ingredient. Various usefulness of cosmetic application including differentiation promoting effect is explained. In addition, Korean Patent Laid-Open No. 10-2018-0108504 proposes a technology in which a specific lactic acid bacteria fermented product of colostrum is applied as a cosmetic composition for alleviating skin irritation, and in Korea Patent No. 10-1974405, alkaline proteolytic enzyme treatment Therefore, it is proposed to provide a cosmetic composition for skin regeneration, which comprises a hydrolyzate of colostrum whey protein having a hydrolysis rate of 40-50% as an active ingredient, which promotes the differentiation of keratinocytes.

However, so far, colostrum-related cosmetic compositions have been used for skin irritation caused by general skin troubles, cosmetic compositions for anti-aging for general environments, and skin regeneration. The cytoprotective effect against dust was difficult to expect.

In particular, as a composition for preventing skin damage caused by contaminants such as fine dust, a peptide composed of a specific amino acid sequence is known in Korean Patent Registration No. 10-2065171.

However, these peptides also have a mechanism to protect skin irritation from dioxins or cigarette smoke, and are due to the effect of preventing skin aging as an existing cosmetic composition. Because it is difficult to expect skin protection against skin toxicity, there is a problem that its effectiveness is very limited.

As such, in the prior art, compositions for protecting skin from heavy metals or ultrafine dust contained in the air, such as fine dust, have not been properly proposed. development is very urgent.

The present invention aims to protect the skin from various problems of the skin caused by contamination of fine dust, such as heavy metal environment or ultrafine dust, which have not been properly solved in the prior art.

Accordingly, the present inventors have continuously researched and developed materials that can effectively block skin cytotoxicity problems caused by fine dust or ultrafine dust containing heavy metals and protect the skin. As a result, colostrum fermentation products contain heavy metals or The present invention was completed by confirming the fact that it has an effect of protecting the skin from cytotoxicity or cancer caused by ultrafine dust.

Accordingly, an object of the present invention is to provide a composition for skin protection having a skin protection effect against cytotoxicity of the skin caused by fine dust containing heavy metals.

In addition, another object of the present invention is to provide a new use of colostrum fermentation products.

In order to solve the problems of the present invention as described above, the present invention provides a skin protection composition for protecting the skin from cytotoxicity caused by heavy metal-containing fine dust containing a colostrum fermentation product as an active ingredient.

In addition, the present invention provides a composition for enhancing skin beauty containing the composition for skin protection.

In addition, the present invention provides a cosmetic composition containing the composition for skin protection.

In addition, the present invention provides a pharmaceutical composition for skin protection for the prevention and treatment of skin cancer caused by fine dust containing the composition for skin protection.

In addition, the present invention provides a skin cleanser containing the composition for skin protection.

The composition for skin protection containing the fermented colostrum according to the present invention as an active ingredient can protect the skin from skin toxicity caused by fine dust containing heavy metals.

Therefore, the composition for skin protection comprising the fermented colostrum of the present invention can prevent skin damage caused by skin toxicity caused by heavy metals contained in fine dust or ultrafine dust, and thus a cosmetic composition applied to the skin, or a pharmaceutical composition for external use. It is very useful as a composition or skin cleanser.

1 is a graph showing the results of heavy metal cytotoxicity of the skin caused by heavy metal-containing fine dust according to an embodiment of the present invention.
2 is a graph showing the result of protecting skin cells from heavy metals contained in fine dust containing heavy metals by fermented colostrum according to an embodiment of the present invention.
3 is a graph showing that the colostrum fermentation product according to an embodiment of the present invention has the effect of reducing Prostaglandin E2 (PEG2) on heavy metal-containing fine dust.
Figure 4 is a graph showing the comparison of the results of the cytotoxicity test for the colostrum fermentation product and the control according to an embodiment of the present invention.

Hereinafter, in order to describe the present invention in detail, it will be described in detail as one embodiment, and also will be described with specific examples such as Examples and Experimental Examples.

However, preferred embodiments or examples or experimental examples according to the present invention may be modified in various other forms, and the scope of the present invention should not be construed as being limited to the examples described below.

Since the Examples and Experimental Examples according to the present invention are merely provided to more completely explain the present invention to those with average knowledge in the art, various equivalents that can be substituted for them at the time of filing of the present invention It should be understood that there may be variations and variations.

The present invention is not for improving parts such as skin troubles or keratinization by using the fermented product of colostrum as a simple cosmetic, but in particular for protecting the skin from damage to the skin from heavy metals caused by fine dust containing heavy metals. It's about use.

In the present invention, the term 'fine dust' includes fine dust containing heavy metals, ultrafine dust, polluted air, waste gas, etc., and as an expression encompassing these, fine dust containing substances that cause skin toxicity by heavy metals It means fine dust that typically contains heavy metals. In the present invention, the size of fine dust refers to dust having a particle diameter of 90 μm or less.

In the present invention, 'fine dust' is road dust or atmospheric dust and includes heavy metals as harmful components, where 'heavy metal' is platinum (Pt), rhodium (Rh), palladium (Pd), aluminum (Al) ), barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), iron (Fe), hafnium (Hf), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), rubidium (Rb), antimony (Sb), strontium (Sr), titanium (Ti), thorium (Th), vanadium (V), yttrium (Y), zinc (Zn), etc. may be included. .

In the present invention, 'cytotoxicity' means skin damage such as keratinocytes, various cancers caused by the above-listed heavy metals such as cadmium, arsenic, lead, and nickel, and skin allergy due to absorption of heavy metals or harmful ingredients, squamous epithelial cells It includes the occurrence of diseases such as cancer and the like.

The colostrum fermentation product used in the present invention may preferably be a colostrum fermentation product obtained by fermenting colostrum with lactic acid bacteria.

In the present invention, colostrum is usually colostrum collected from mammals, such as breast milk, cows, sheep, goats, horses, goats, etc., and refers to colostrum collected within 7 weeks postpartum, more preferably within 4 days. Colostrum can be used after cooling the metal and sterilizing it.

As the bacteria applied to the fermentation of colostrum in the present invention, preferably single lactic acid bacteria or complex lactic acid bacteria can be used, more preferably, it is preferable to use a combination of Lactobacillus and Streptococcus bacteria.

Specifically exemplifying the bacteria usable for fermentation in the present invention, for example, Lactobacillus delbrueckii subsp. bulgaricus ), Streptococcus thermophilus ), Lactobacillus rhamnosus GG ) Acidophilus ( Lactobacillus acidophilus ), Lactobacillus casei ( Lactobacillus casei subsp. casei ), At least one selected from Lactobacillus plantarum subsp. plantarum may be preferably used.

For example, preferred examples include Lactobacillus delbrueckii subsp. bulgaricus , Lactobacillus rhamnosus GG , and Streptococcus thermophilus . may exhibit a more enhanced synergistic effect.

In particular, according to the present invention, the fermentation is far more preferably performed under aerobic conditions in order to satisfy active conditions for the protection of cytotoxicity rather than anaerobic conditions.

According to a preferred embodiment of the present invention, fermented bacteria can be inoculated into pasteurized colostrum, which is a fermentation raw material, and fermented for 30 to 120 minutes at a temperature of 15-50 ° C.

According to a preferred embodiment of the present invention, after the aerobic fermentation process, it is centrifuged to obtain a fermentation broth to obtain an aerobic fermentation product of colostrum.

According to a preferred embodiment of the present invention, the aerobic fermentation product of colostrum of the present invention may be casein-free.

Therefore, according to a preferred embodiment of the present invention, the colostrum fermentation product can be preferably additionally prepared by using the fermentation broth to obtain a fermentation extract using an enzyme.

According to the present invention, the step of obtaining a fermentation extract by using the enzyme in the fermentation broth is, for example, preferably through an aggregation process for purifying the colostrum fermentation broth that has undergone an aerobic fermentation process.

According to a preferred embodiment of the present invention, the fermented product of colostrum may be preferably used from which casein has been removed.

The fermentation product of colostrum according to the present invention may include various types of products obtained after fermenting colostrum. Preferably, the supernatant obtained by centrifugation after fermenting colostrum may be used. More preferably, an aggregate formed by adding rennet to the supernatant to remove casein, or a fermentation extract obtained by centrifuging the aggregate or a filtrate thereof may be used as a fermentation product.

According to a preferred embodiment of the present invention, the colostrum fermentation product is Streptococcus thermophilus ( Streptococcus thermophilus ) and Lactobacillus ( Lactobacillus ) Lactobacillus Streptococcus thermophilus colostrum fermentation by filtering the lysate obtained by fermenting colostrum A dissolution filtrate can be preferably used.

According to a preferred embodiment of the present invention, the fermented product of colostrum according to the present invention can be applied for skin protection in case of skin contact with fine dust containing heavy metals. When heavy metals are introduced in vivo, they are not immediately excreted, but are bound to proteins and the synthesis of metallothionein protein is increased in the liver and kidneys. This protein combines with thiolate to form a heavy metal-protein complex, thereby eliminating the toxicity of heavy metals. However, heavy metal accumulation occurs in the body where the metallothionein receptor is saturated, and toxicity is expressed. It was reported that metallothionein with a high cysteine content in vitro binds to heavy metals such as Cd and plays a role in protecting against cytotoxicity by reversing the activity of Ca-ATPase, which affects calcium homeostasis (Imsoon Choi et al. Korean J. Zool. 36: 529- 534 (1993)). In particular, amino acids such as cysteine in colostrum have a thiol (-SH) functional group and can form strong bonds with heavy metals. Therefore, due to the combination of heavy metals and amino acids such as cysteine with abundant protein in colostrum, heavy metals inhibit and inhibit toxicity to skin cells and skin cancer.

Harmful components such as heavy metals contained in fine dust include platinum (Pt), rhodium (Rh), palladium (Pd), aluminum (Al), barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), Iron (Fe), hafnium (Hf), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), rubidium (Rb), antimony (Sb), strontium (Sr), titanium ( Ti), thorium (Th), vanadium (V), yttrium (Y), zinc (Zn), etc., sulfuric acid or polycyclic aromatic hydrocarbons produced during the combustion of fossil fuels. Among them, cadmium, arsenic, lead, nickel, etc. classified as group 1 carcinogens by the International Agency for Research on Cancer (IARC) are known to be cytotoxic and cause skin cancer.

In fact, it has been studied that heavy metals contained in fine dust inhibit DNA repair and cause cancer (Asmuss M. et al., Carcinogenesis, 21: 2097-2104 (2000)). Therefore, the composition for skin protection containing the fermented colostrum of the present invention can be prevented in advance by fundamentally blocking fine dust containing heavy metals from the skin or by protecting the skin from skin toxicity or skin cancer caused by heavy metals through protein binding.

According to the present invention, skin cancer is a representative lesion caused by skin cytotoxicity caused by heavy metals contained in fine dust. can Therefore, in the present invention, the fermented colostrum can be used as a skin protection composition in order to protect against diseases caused by the accumulation of heavy metals contained in fine dust on the skin.

Here, skin cancer is a generic term for all malignant skin diseases, and may include various types such as basal cell carcinoma, melanoma, Kaposi's sarcoma, and squamous cell carcinoma.

According to a preferred embodiment of the present invention, the fermented product of colostrum according to the present invention may be used in an amount of 1-30% by weight, preferably 1-20% by weight, in the overall composition for skin protection. As another example, when used as an external preparation for skin, such as a cosmetic composition, external preparation, pharmaceutical composition, etc., it may be used in an amount of 1-5% by weight.

In addition, such a composition of the present invention can be used as a skin cleanser, typically a face wash, applied to the skin.

According to the present invention, when the composition for skin protection as described above is used as a cosmetic composition or a composition for enhancing skin beauty, it can be formulated and used as a cream, and is used as a cosmetic composition for moisturizing, whitening, wrinkle improvement, or sunscreen It can be used for skin protection.

In addition, according to a preferred embodiment of the present invention, the composition obtained as a fermented product of colostrum may be applied as a food composition.

In addition, according to a preferred embodiment of the present invention, the composition obtained from the fermented product of colostrum may be applied as a pharmaceutical composition for outer skin. For example, it may be applied in the form of an ointment, cream, or patch.

The skin application composition containing the fermented colostrum of the present invention as an active ingredient can be applied by applying it to the skin several times at 1-500 mg/ml specifically.

In this form, even when manufactured and applied as a cosmetic to be applied to the skin, it can also be prepared by composing 1-500 mg/ml.

According to a preferred embodiment of the present invention, more preferably 10-400 mg/ml may be applied.

According to a preferred embodiment of the present invention, the cosmetic using the cosmetic composition for moisturizing containing the fermented colostrum according to the present invention as an active ingredient, or the composition or skin ointment for enhancing skin beauty containing the fermented colostrum as an active ingredient is the Within the content range, for example, 50 mg/ml, 100 mg/ml, 200 mg/ml, 400 mg/ml, etc. may be prepared in various amounts and preferably applied to the skin 1-5 times a day.

In addition, the health food or pharmaceutical composition according to the present invention may be orally administered 1-3 times a day at 50 mg, 100 mg, 200 mg, 400 mg, 500 mg or 1,000 mg per tablet, for example, as an oral agent.

According to a preferred embodiment of the present invention, if the colostrum fermentation product is outside the lower limit of the content range, the effect is significantly reduced, and if it is out of the upper limit, it is difficult to prepare a composition or formulation for skin application, or compared to the added amount Since the expected effect is not greatly improved, it is not preferable from an economic point of view.

When the composition of the present invention is used for skin protection, there is an effect of protecting the skin from skin cytotoxicity of the face, etc. caused by fine dust containing heavy metals.

Hereinafter, the present invention will be described in detail based on examples. However, the scope of the present invention is not limited only to the following examples, and includes modifications of technical ideas equivalent thereto.

Example: Preparation of colostrum fermentation products

Step 1: Preparing colostrum

To prepare fermented products from colostrum, freshly squeezed colostrum is rapidly cooled, put in a constant temperature water tank, and sterilized for 30 minutes after the temperature of colostrum reaches 63 ° C. Then, the temperature is lowered to 35 ° C to prepare fermentation raw materials.

Step 2: Preparation of fermented colostrum

Lactobacillus Bulgaria kusu (Lactobacillus delbrueckii subsp. Bulgaricus, ATCC 11842), Streptococcus Thermo filler's (Streptococcus thermophilus, ATCC 19258), Lactobacillus ramno suspension support (Lactobacillus rhamnosus GG, ATCC 53103) , also Lactobacillus know peel Ruth (Lactobacillus acidophilus, ATCC 4356), Lactobacillus casei ( Lactobacillus casei subsp. casei, ATCC 393), Lactobacillus plantarum ( Lactobacillus plantarum subsp. plantarum ATCC 10241) is inoculated into the fermentation raw material of the first step at 1 x 10 ⁴ cfu / mL and fermented at a temperature of 35 ° C. for 60 minutes to obtain a fermented product (fermented liquid).

Step 3: Preparation of fermented colostrum

The fermentation broth obtained in the second step is centrifuged at 2000 rpm for 20 minutes to remove suspended matter, and the supernatant except for the sediment is recovered to obtain fermented colostrum as a fermentation product of colostrum. After adjusting the fermented colostrum to 33° C. and adding rennet to coagulate it for 60 minutes, the fermented colostrum is recovered. The fermented colostrum processed product obtained above is centrifuged at 13,000 rpm for 60 minutes, and the supernatant is obtained as a lactic acid bacteria fermentation product, fermented colostrum. After secondary filtration of the supernatant with filter papers of 0.4 μm and 0.2 μm, a colostrum fermentation product was prepared as a final colostrum fermentation product.

Experimental Example 1: Cytotoxic effect of fine dust (PM) containing heavy metals

Cytotoxicity is determined by Moseman's method (Moseman T., J. Immuno. Methods, 65, 55 (1983)) and by Skaper et al. (Skaper SD., et al., Cell Culture, 2, 17-33 (1990)). MTT (3-4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazolium bromide) using Human-derived keratinocytes HaCaT were cultured in 96 well plates. After 24 hours of PM treatment, the MTT solution was treated in each well and reacted at 37° C. for 4 hours. After removing the medium, DMSO was added to melt the formed formazan crystal, and it was measured at 595 nm using an ELISA reader. Toxicity to cells was expressed as a percentage of the average absorbance value of each control.

In order to investigate the cytotoxicity of PM in human-derived keratinocytes, when treated by concentration, the degree of change in cell proliferation was calculated compared to that treated with DMSO, a control, to investigate cytotoxicity.

The results are shown in the accompanying drawings [Fig. 1]. According to these results, in the case of PM, cytotoxicity was shown in a concentration-dependent manner up to 200 ug/mL.

Experimental Example 2: Cell protective effect against heavy metal-containing fine dust of colostrum fermentation product (FC)

Human-derived keratinocytes HaCaT were cultured in 96 well plates. After 24 hours treatment with PM and FC and dust containing heavy metals such as cadmium, chromium, and lead for 24 hours, MTT solution was treated and reacted in each well. After removing the medium, DMSO was added to melt the formed formazan crystal, and it was measured at 595 nm using an ELISA reader. The protective effect of cells was expressed as a percentage of the average absorbance value of each control.

To confirm the protection of human-derived keratinocytes from fine dust containing heavy metals, PM 0.200 μg/mL concentration and FC 3% were simultaneously treated. And compared with the untreated group, the degree of change in cell viability was confirmed.

This result is shown in the accompanying drawing [Fig. 2].

Referring to FIG. 2 , it was confirmed that the colostrum fermentation product according to the above example inhibited skin cell damage caused by fine dust containing heavy metals.

On the other hand, in the case of Chunma extract, which is well known for its anti-inflammatory effect, used as a comparative product in this experiment, there was no cytoprotective effect from fine dust containing heavy metals at a non-toxic concentration of 5 ug/ml.

From these experimental results, it can be seen that the colostrum fermentation product according to the embodiment is very effective in inhibiting skin cell damage caused by dust containing heavy metals.

In particular, due to the cytoprotective effect of this colostrum fermentation product, it can be confirmed that the colostrum fermentation product used herein is harmless without toxicity to the human body.

Experimental Example 3: Measurement of PEG production

Human-derived keratinocytes HaCaT were cultured in a 24-well plate. The supernatant was obtained by treating colostrum fermentation products with dust of 90 μm or less containing heavy metals such as cadmium, chromium, and lead for 24 hours. PEG2 of the obtained supernatant was measured using an ELISA kit (R&D Systems Inc., Minneapolis, MN, USA).

This result is shown in the accompanying drawing [FIG. 3].

Referring to FIG. 3 , it was found that the colostrum fermentation product according to the above example significantly reduced the generation of PGE2 caused by dust containing heavy metals.

Experimental Example 4: Cytotoxicity test

For each sample, cell viability was measured by MTT assay.

MTT assay is an experimental method widely used for cell proliferation and toxicity by measuring the number of living cells. Live cells are water-soluble in mitochondria, and MTT, a yellow salt, is reduced to a water-insoluble blue formazan derivative by succinate dehydrogenase. to use the principle of

First, HaCaT cells were inoculated into a 6-well plate at ^{a density of 1x10 5} cells/well and cultured at 37°C for one day. Then, each sample (milk, milk fermentation, colostrum, colostrum fermentation) was treated in each well by concentration (1, 5, 10, 20, 40, 50ug/ml). Then, after incubation for 12 hours and 24 hours at 37 ° C, the MTT solution was treated, and after activation for 1 hour, it was measured at 450 nm with an ELISA reader. The control was performed with H ₂ O ₂ , and the cell viability was shown compared to the control.

The experimental results are shown in Table 1 and [Fig. 4] below, it was confirmed that the colostrum fermentation product (colostrum fermentation) showed superior survival rate compared to other comparative groups.

12H control 100 0.2 milk 1ug/ml 90 0.05 10ug/ml 118 0.1 20ug/ml 107 0.04 milk fermentation 1ug/ml 100 0.06 10ug/ml 105 0.18 20ug/ml 94 0.1 beestings 1ug/ml 81 0.1 10ug/ml 108 0.11 20ug/ml 106 0.07 colostrum fermentation 1ug/ml 122 0.18 10ug/ml 126 0.14 20ug/ml 125 0.26

As described above, the composition containing the fermented colostrum of the present invention as an active ingredient can be utilized as a skin protection composition that expresses a protective effect from cellular damage to the skin caused by fine dust containing heavy metals, and skin using the same It can be applied as a cosmetic composition, a cosmetic composition, or a pharmaceutical composition for skin.

In addition, since such a composition for skin protection can be used as a natural material composition such as a skin bio material, it can be used as a very useful bio material when applied as an additive for various types of skin cell protection in the bio-bio-pharmaceutical industry.

Claims (7)

A skin protection composition for protecting the skin from cytotoxicity caused by heavy metal-containing fine dust, containing a colostrum fermentation product as an active ingredient.
The method according to claim 1, wherein the colostrum fermentation product is Streptococcus thermophilus ( Streptococcus thermophilus ) and Lactobacillus ( Lactobacillus ) It is characterized in that the lysate obtained by fermenting colostrum is filtered Lactobacillus Streptococcus thermophilus colostrum fermentation dissolved filtrate. A composition for skin protection.
The composition for skin protection according to claim 1 or 2, wherein the colostrum fermentation product is a fermentation product fermented under aerobic conditions.
A composition for promoting skin beauty, comprising a composition for protecting the skin from cytotoxicity caused by heavy metal-containing fine dust, containing a fermented colostrum as an active ingredient.
A cosmetic composition comprising a skin protection composition for protecting the skin from cytotoxicity caused by heavy metal-containing fine dust, containing a colostrum fermentation product as an active ingredient.
A pharmaceutical composition for skin for the prevention and treatment of skin cancer caused by fine dust, comprising a composition for protecting the skin from cytotoxicity caused by heavy metal-containing fine dust, containing a colostrum fermentation product as an active ingredient.
A skin cleanser comprising a skin protection composition for protecting the skin from cytotoxicity caused by heavy metal-containing fine dust, containing a colostrum fermentation product as an active ingredient.

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