KR20210101344A - Method of extracting high concentration cannabinoid oil from hemp seed - Google Patents

Method of extracting high concentration cannabinoid oil from hemp seed Download PDF

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KR20210101344A
KR20210101344A KR1020200014604A KR20200014604A KR20210101344A KR 20210101344 A KR20210101344 A KR 20210101344A KR 1020200014604 A KR1020200014604 A KR 1020200014604A KR 20200014604 A KR20200014604 A KR 20200014604A KR 20210101344 A KR20210101344 A KR 20210101344A
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oil
hemp
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조 케빈
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제이킨 앤드 보아즈 코프
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material

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Abstract

The present invention relates to a method for extracting high-concentration cannabinoid oil from hemp seeds, including the steps of: (a) introducing hemp seeds to an oil press and carrying out compression; (b) collecting the oil extracted from the compressed hemp seeds in an oil container; (c) supplying hemp seed continuously to the oil press of step (a) and continuing compression and oil collection; and (d) covering the oil container in which the hemp seed oil is collected in step (c) with a lid, and storing the oil container at room temperature in a dark place to separate oil from water or impurities extracted during the compression. According to the present invention, it is possible to provide a method for extracting cannabinoid oil containing cannabinoid at a high concentration from hemp seed oil compressed and extracted merely by using naturally occurring hemp seeds.

Description

햄프씨드로부터 고농도 칸나비노이드 오일을 추출하는 방법{METHOD OF EXTRACTING HIGH CONCENTRATION CANNABINOID OIL FROM HEMP SEED}Method of extracting high concentration cannabinoid oil from hemp seeds

본 발명은 햄프씨드로부터 고농도 칸나비노이드 오일을 추출하는 방법에 관한 것으로, 보다 상세하게는 껍질이 완전히 제거된 천연물질인 햄프씨드만을 이용하여 고농도의 칸나비노이드(CBD) 오일을 추출하는 방법에 관한 것이다.The present invention relates to a method for extracting high-concentration cannabinoid oil from hemp seeds, and more particularly, to a method for extracting high-concentration cannabinoid (CBD) oil using only hemp seeds, a natural material from which the skin has been completely removed. it's about

칸나비노이드(cannabinoid)는 다양한 화합물의 한 종류로 칸나비노이드 수용체를 활성화시킨다. 칸나비노이드는 사람과 동물에서 자연스럽게 합성되는 엔도칸나비노이드(endocannabinoid)가 포함되어 있다. 식물성 칸나비노이드(phytocannabinoids)는 칸나비스(cannabis)와 다른 식물에서 발견되며, 칸나비노이드의 다른 다양한 효과들도 있다.Cannabinoids are a class of various compounds that activate cannabinoid receptors. Cannabinoids include endocannabinoids that are synthesized naturally in humans and animals. Phytocannabinoids are found in cannabis and other plants, and there are various other effects of cannabinoids.

칸나비디올(Cannabidiol)은 많은 질병에 사용되는 유명한 자연 치료제이다. CBD로 잘 알려져 있으며 마리화나 식물에서 발견되는 칸나비노이드로 알려진 104가지 화학물질 중 하나이다. CBD 오일에는 칸나비스 식물에서 추출되었지만 환각성을 유발하는 THC 성분은 함유되어 있지 않다.Cannabidiol is a popular natural remedy used for many ailments. Better known as CBD, it is one of 104 chemicals known as cannabinoids found in the marijuana plant. CBD oil is derived from the cannabis plant but does not contain hallucinogenic THC.

칸나비스 오일은 만성통증, 염증, 응급 통증을 호소하는 사람들에게 좋은 효과가 있다고 알려져 있다. 암환자들에게 화학요법, 질병 자체의 고통으로부터 벗어날 필요가 있을때 추천되기도 한다. CBD는 다발성 경화증 및 류마티스 관절염과 같은 질병과 관련된 통증을 감소시키고 수면촉진, 염증을 감소시키는데 효과적이다.Cannabis oil is known to be good for people who complain of chronic pain, inflammation, and emergency pain. It is also recommended for cancer patients when they need to get rid of the pain of chemotherapy and the disease itself. CBD is effective in reducing pain, promoting sleep, and reducing inflammation associated with diseases such as multiple sclerosis and rheumatoid arthritis.

불안감과 우울증은 정신건강의 장애이다. 불안증과 우울들은 졸음, 불면증, 성기능장애, 두통 등 부작용을 일으킬 수 있는 의약품으로 치료된다. CBD 오일은 외상후 스트레스 장애, 어린이들의 불면증, 불안을 안전하게 치료한다.Anxiety and depression are mental health disorders. Anxiety and depression are treated with medicines that can cause side effects such as drowsiness, insomnia, sexual dysfunction, and headaches. CBD oil is a safe treatment for post-traumatic stress disorder, insomnia and anxiety in children.

메스꺼움, 구토, 통증과 암 치료와 관련된 부작용 및 암과 관련된 증상을 줄이는데 도움이 된다. 연구 보고서에 따르면 CBD 오일의 활성 성분이 종양의 크기를 줄이고 암 예방 효과를 나타낼 수 있다고 한다. 또한 CBD 오일의 가장 많이 연구된 질환이 간질, 다발성경화증 같은 신경계 질환 치료제이다. 가장 효과를 많이 보는 부분이기도 하다. It helps reduce nausea, vomiting, pain and the side effects associated with cancer treatment and symptoms associated with cancer. According to research reports, the active ingredients in CBD oil can reduce the size of tumors and have cancer-preventing effects. In addition, the most studied diseases of CBD oil are the treatment of neurological diseases such as epilepsy and multiple sclerosis. It is also the part that works the most.

CBD 오일은 통증과 떨림을 줄여서 파킨슨병 환자의 삶의 질과 수면의 질이 향상된다는 연구 결과가 있다. 취침 전 CBD 오일을 사용하고 취침할 경우 보다 나은 수면을 취할 수 있다고 한다. Studies have shown that CBD oil reduces pain and tremors, improving the quality of life and quality of sleep in people with Parkinson's disease. If you use CBD oil before bedtime and go to bed, you will get a better night's sleep.

THC는 사용자에게 오래 지속되는 부작용이 있는 향정신성 화합물이지만, CBD는 향정신제로 간주되지 않으며 다양한 투여 경로에서 소비에 안전하다고 알려져 있다. 두 화합물은 일반적으로 다양한 농도 범위에서 식물 공급원에서 혼합물로 발견된다. 약학 조성물로 제형화하기 위해, 칸나비노이드는 종종 다양한 방법에 의해 식물 공급원으로부터 추출된다.Although THC is a psychoactive compound with long lasting side effects for users, CBD is not considered a psychotropic and is known to be safe for consumption by various routes of administration. The two compounds are usually found as mixtures in plant sources in various concentration ranges. For formulation into pharmaceutical compositions, cannabinoids are often extracted from plant sources by a variety of methods.

다양한 식물 공급원으로부터 다양한 화합물의 추출을 얻는데 사용되는 추가 방법은 초-임계 CO2 추출이다. CO2 추출 방법에서, 초-임계 조건 (즉, 고온 및 고압)에서의 CO2가 칸나비노이드 종의 추출에 사용된다. 식물 공급원으로부터 다양한 화합물을 추출하는데 비교적 효과적이지만, 이 기법은 액체 추출에 비해 종종 더 복잡하고, 시간이 많이 소요되며, 매우 비싸다. 또한, 이 기법은 특정 칸나비노이드에 대해 선택하는 것보다는 다양한 정유(essential oils)를 동시에 추출할 수도 있다.A further method used to obtain extraction of various compounds from various plant sources is super-critical CO2 extraction. In the CO2 extraction method, CO2 at super-critical conditions (ie high temperature and high pressure) is used for the extraction of cannabinoid species. Although relatively effective in extracting various compounds from plant sources, this technique is often more complex, time consuming and very expensive compared to liquid extraction. Additionally, the technique may simultaneously extract a variety of essential oils rather than selecting for a specific cannabinoid.

칸나비노이드의 추출을 위한 다양한 방법이 존재하지만, 이들 모두는 낮은 추출 수율 및 낮은 (또는 없는) 선택도의 공통적인 단점을 가진다. 즉, 지금까지 알려진 추출 방법은 식물 공급원으로부터 다양한 종의 칸나비노이드를 추출하고, 종종 다양한 농도 및 비의 CBD 및 THC의 혼합물을 야기하여, 약학 조성물에서 CBD의 후속 제형 및 사용을 방해한다.Although various methods exist for the extraction of cannabinoids, they all have the common disadvantages of low extraction yield and low (or no) selectivity. That is, the extraction methods known heretofore extract various species of cannabinoids from plant sources, often resulting in mixtures of CBD and THC in varying concentrations and ratios, preventing subsequent formulation and use of CBD in pharmaceutical compositions.

본 발명은 상기와 같은 문제점을 해결하기 위하여 안출된 것으로, 천연물질인 햄프씨드만을 이용하여 압착추출한 햄프씨드 오일로부터 칸나비노이드를 고농도로 함유하는 칸나비노이드 오일을 추출하는 방법을 제공하는데 그 목적이 있다.The present invention has been devised to solve the above problems, and it is to provide a method of extracting cannabinoid oil containing a high concentration of cannabinoids from hemp seed oil compressed and extracted using only hemp seeds, which are natural substances. there is this

본 발명은 상기와 같은 목적을 달성하기 위한 것으로, (a) 햄프씨드를 오일 프레스에 넣어 압착하는 단계; (b) 상기 압착된 햄프씨드로부터 추출된 오일을 오일 용기에 수집하는 단계; (c) 상기 (a)단계의 오일 프레스에 계속 햄프씨드를 공급하여 압착 및 (b) 오일 수집을 지속적으로 진행하는 단계; 및 (d) 상기 (c)단계에서 햄프씨드 오일을 수집한 오일 용기에 뚜껑을 닫고 상온 및 어두운 장소에 보관함으로써, 압축시 추출된 물 또는 불순물로부터 오일을 분리하는 단계를 포함하는 햄프씨드로부터 고농도 칸나비노이드 오일을 추출하는 방법을 제공한다.In order to achieve the above object, the present invention comprises the steps of: (a) pressing the hemp seeds into an oil press; (b) collecting the oil extracted from the pressed hemp seeds in an oil container; (c) continuously supplying hemp seeds to the oil press of step (a) to continuously perform compression and (b) oil collection; and (d) separating the oil from water or impurities extracted during compression by closing the lid on the oil container in which the hemp seed oil was collected in step (c) and storing it at room temperature and in a dark place. A method for extracting cannabinoid oil is provided.

또한, 상기 방법은, (e) 상기 (d)단계에서 분리된 오일에 표준도수의 알콜을 혼합하여 교반하는 단계; (f) 상기 (e)단계의 교반된 오일을 냉장실, 냉동실 또는 재킷 필터 반응기에서 냉각 온도에 보관하는 단계; (g) 상기 (f)단계의 냉각 보관된 오일을 여과함으로써 지질, 지방 및 왁스를 제거하는 단계; 및 (h) 상기 (g)단계의 여과된 오일에 열을 가하여 알콜을 증발시키는 단계를 더 포함하는 것을 특징으로 한다.In addition, the method comprises the steps of (e) mixing the oil separated in step (d) with an alcohol of standard alcohol and stirring; (f) storing the stirred oil of step (e) at a cooling temperature in a refrigerator compartment, a freezer compartment or a jacketed filter reactor; (g) removing lipids, fats and waxes by filtering the oil stored in the cold storage of step (f); and (h) evaporating the alcohol by applying heat to the filtered oil of step (g).

또한, 상기 방법은, (i) 상기 (h)단계의 오일로부터 THC를 제거하는 단계를 더 포함하는 것을 특징으로 한다.In addition, the method is characterized in that it further comprises the step of (i) removing THC from the oil of step (h).

본 발명은, 천연물질인 햄프씨드만을 이용하여 압착추출한 햄프씨드 오일로부터 칸나비노이드를 고농도로 함유하는 칸나비노이드 오일을 추출하는 방법을 제공할 수 있다.The present invention can provide a method for extracting cannabinoid oil containing a high concentration of cannabinoids from hemp seed oil compressed and extracted using only hemp seeds, which are natural substances.

본 발명은, (a) 햄프씨드를 오일 프레스에 넣어 압착하는 단계; (b) 상기 압착된 햄프씨드로부터 추출된 오일을 오일 용기에 수집하는 단계; (c) 상기 (a)단계의 오일 프레스에 계속 햄프씨드를 공급하여 압착 및 (b) 오일 수집을 지속적으로 진행하는 단계; 및 (d) 상기 (c)단계에서 햄프씨드 오일을 수집한 오일 용기에 뚜껑을 닫고 상온 및 어두운 장소에 보관함으로써, 압축시 추출된 물 또는 불순물로부터 오일을 분리하는 단계를 햄프씨드로부터 고농도 칸나비노이드 오일을 추출하는 방법에 관한 것이다.The present invention, (a) the step of pressing the hemp seeds into an oil press; (b) collecting the oil extracted from the pressed hemp seeds in an oil container; (c) continuously supplying hemp seeds to the oil press of step (a) to continuously perform compression and (b) oil collection; and (d) separating the oil from water or impurities extracted during compression by closing the lid on the oil container in which the hemp seed oil was collected in step (c) and storing it at room temperature and in a dark place. It relates to a method of extracting noid oil.

이하, 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명은 천연물질인 햄프씨드의 껍질이 제거된 상태의 것만을 이용하여 칸나비노이드의 함량이 고농도로 함유된 오일을 추출하는 방법에 관한 것으로, 본 발명의 일양태에 따르면 다음과 같은 단계의 공정을 포함한다:The present invention relates to a method for extracting an oil containing a high concentration of cannabinoids using only a state in which the skin of hemp seeds, which is a natural material, has been removed. The process includes:

(a) 햄프씨드를 오일 프레스에 넣어 압착하는 단계(a) pressing the hemp seeds in an oil press

(b) 상기 압착된 햄프씨드로부터 추출된 오일을 오일 용기에 수집하는 단계(b) collecting the oil extracted from the pressed hemp seeds in an oil container

(c) 상기 (a)단계의 오일 프레스에 계속 햄프씨드를 공급하여 압착 및 (b) 오일 수집을 지속적으로 진행하는 단계(c) continuously supplying hemp seeds to the oil press of step (a) to continuously perform compression and (b) oil collection

(d) 상기 (c)단계에서 햄프씨드 오일을 수집한 오일 용기에 뚜껑을 닫고 상온 및 어두운 장소에 보관함으로써, 압축시 추출된 물 또는 불순물로부터 오일을 분리하는 단계(d) separating the oil from the water or impurities extracted during compression by closing the lid on the oil container in which the hemp seed oil was collected in step (c) and storing it at room temperature and in a dark place

본 발명의 다른 양태에 따르면, 다음 단계들을 더 포함하는 한다:According to another aspect of the present invention, the method further comprises the following steps:

(e) 상기 (d)단계에서 분리된 오일에 표준도수의 알콜을 혼합하여 교반하는 단계(e) mixing the oil separated in step (d) with alcohol of standard alcohol and stirring

(f) 상기 (e)단계의 교반된 오일을 냉장실, 냉동실 또는 재킷 필터 반응기에서 냉각 온도에 보관하는 단계(f) storing the stirred oil of step (e) at a cooling temperature in a refrigerator compartment, a freezer compartment or a jacketed filter reactor

(g) 상기 (f)단계의 냉각 보관된 오일을 여과함으로써 지질, 지방 및 왁스를 제거하는 단계(g) removing lipids, fats and waxes by filtering the oil stored in the cold storage of step (f)

(h) 상기 (g)단계의 여과된 오일에 열을 가하여 알콜을 증발시키는 단계(h) evaporating the alcohol by applying heat to the filtered oil of step (g)

본 발명의 또 다른 일양태에 따르면, 다음 단계를 더 포함한다:According to another aspect of the present invention, it further comprises the following steps:

(i) 상기 (h)단계의 오일로부터 THC를 제거하는 단계(i) removing THC from the oil of step (h)

이하, 본 발명을 하기 실시예에 의거하여 보다 상세히 설명한다.Hereinafter, the present invention will be described in more detail based on the following examples.

[실시예][Example]

대마 씨앗을 눌러 오일 프레스에 공급하였다. 오일 용기를 점검하면서, 용기가 가득 차면 용기를 꺼내고, 큰 유리 병에 압착된 오일을 옮겨 담았다. 많은 양의 모든 씨앗을 압착할 때까지 호퍼에 씨앗을 계속 공급하여 공정이 연속적으로 이루어지도록 하였다.Hemp seeds were pressed and fed to an oil press. While checking the oil container, when the container is full, the container is removed and the pressurized oil is transferred to a large glass bottle. The process was continuously carried out by continuously feeding the seeds into the hopper until all the seeds in a large quantity had been pressed.

압착하여 수집한 햄프씨드유가 들어있는 유리 용기 뚜껑을 닫고, 따뜻하고 어두운 곳에 두어 압축하는 동안 추출된 물이나 기타 물질 등의 불순물과 오일을 분리하였다. 하루 정도 지난 후에 물 등의 불순물로부터 햄프씨드 오일만을 분리하여 별도의 용기에 보관한다.The glass container containing the hemp seed oil collected by compression was closed, and the oil was separated from impurities such as water and other substances extracted during compression by placing it in a warm and dark place. After a day or so, separate the hemp seed oil from impurities such as water and store it in a separate container.

추출된 오일은 원유이므로 정제 공정을 별도로 추가하였다.Since the extracted oil is crude oil, a refining process was separately added.

추출된 오일을 표준도수의 알코올과 혼합하고, 완전히 혼합될 때까지 격렬하게 교반하였다. 그 후 약 12시간 동안 냉각상태로 보관한다. The extracted oil was mixed with standard alcohol and stirred vigorously until completely mixed. After that, keep it in a cool state for about 12 hours.

이 냉각 과정은 냉장실, 냉동실 또는 재킷 용기 또는 재킷 필터 반응기에서 수행할 수 있다. 재순환 냉각 장치를 사용하면 재킷이 달린 용기를 -20 ℃까지 냉각 할 수 있다. This cooling process can be carried out in a refrigerator compartment, a freezer compartment or a jacketed vessel or jacketed filter reactor. The use of recirculating chillers can cool jacketed vessels down to -20 °C.

냉각 보관된 오일 원유는 흐릿한 상태로 되어있었고, 이를 여과지를 통해 추출 용기에 넣어, 여과 공정을 통해 추가로 불순물이 여과되도록 하였다. 이러한 여과공정을 통하여 지질, 지방 및 왁스를 제거하였다.The chilled oil crude oil was in a hazy state, and it was placed in an extraction vessel through filter paper to allow further filtration of impurities through a filtration process. Lipids, fats and waxes were removed through this filtration process.

여과된 오일로부터 알콜을 제거하기 위하여 오일에 열을 가함으로써 알콜을 증발시킨다.The alcohol is evaporated by heating the oil to remove the alcohol from the filtered oil.

무용매의 정제된 추출물을 진공 오븐의 트레이에서 건조시켜 황색에서 호박색의 결정같은 물질을 얻을 수 있으며, 이 물질에는 테르펜, THC 및 기타 칸 나비노이드가 포함되어 있으므로, THC를 제거하였다.The solvent-free purified extract was dried on a tray in a vacuum oven to obtain a yellow to amber crystalline substance, which contained terpenes, THC and other cannabinoids, and thus THC was removed.

이로부터 THC는 포함되지 않으면서, CBD의 함량이 고농도로 포함되어 있는 칸나비노이드 오일을 추출할 수 있었다.From this, it was possible to extract cannabinoid oil containing high concentration of CBD without THC.

Claims (3)

(a) 햄프씨드를 오일 프레스에 넣어 압착하는 단계;
(b) 상기 압착된 햄프씨드로부터 추출된 오일을 오일 용기에 수집하는 단계;
(c) 상기 (a)단계의 오일 프레스에 계속 햄프씨드를 공급하여 압착 및 (b) 오일 수집을 지속적으로 진행하는 단계;및
(d) 상기 (c)단계에서 햄프씨드 오일을 수집한 오일 용기에 뚜껑을 닫고 상온 및 어두운 장소에 보관함으로써, 압축시 추출된 물 또는 불순물로부터 오일을 분리하는 단계
를 포함하는 햄프씨드로부터 고농도 칸나비노이드 오일을 추출하는 방법.
(a) pressing the hemp seeds in an oil press;
(b) collecting the oil extracted from the pressed hemp seeds in an oil container;
(c) continuously supplying hemp seeds to the oil press of step (a) to continuously perform compression and (b) oil collection; and
(d) separating the oil from the water or impurities extracted during compression by closing the lid on the oil container in which the hemp seed oil was collected in step (c) and storing it at room temperature and in a dark place
A method of extracting high concentration cannabinoid oil from hemp seeds comprising a.
제1항에 있어서, 상기 방법은,
(e) 상기 (d)단계에서 분리된 오일에 표준도수의 알콜을 혼합하여 교반하는 단계;
(f) 상기 (e)단계의 교반된 오일을 냉장실, 냉동실 또는 재킷 필터 반응기에서 냉각 온도에 보관하는 단계;
(g) 상기 (f)단계의 냉각 보관된 오일을 여과함으로써 지질, 지방 및 왁스를 제거하는 단계;및
(h) 상기 (g)단계의 여과된 오일에 열을 가하여 알콜을 증발시키는 단계
를 더 포함하는 것을 특징으로 하는 햄프씨드로부터 고농도 칸나비노이드 오일을 추출하는 방법.
The method of claim 1, wherein the method comprises:
(e) mixing the oil separated in step (d) with alcohol of standard alcohol and stirring;
(f) storing the stirred oil of step (e) at a cooling temperature in a refrigerator compartment, a freezer compartment or a jacketed filter reactor;
(g) removing lipids, fats and waxes by filtering the oil stored in the cold storage of step (f); and
(h) evaporating the alcohol by applying heat to the filtered oil of step (g)
Method for extracting high concentration cannabinoid oil from hemp seeds, characterized in that it further comprises.
제2항에 있어서, 상기 방법은,
(i) 상기 (h)단계의 오일로부터 THC를 제거하는 단계
를 더 포함하는 것을 특징으로 하는 햄프씨드로부터 고농도 칸나비노이드 오일을 추출하는 방법.
The method of claim 2, wherein the method comprises:
(i) removing THC from the oil of step (h)
Method for extracting high concentration cannabinoid oil from hemp seeds, characterized in that it further comprises.
KR1020200014604A 2020-02-07 2020-02-07 Method of extracting high concentration cannabinoid oil from hemp seed KR20210101344A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102443883B1 (en) * 2022-04-14 2022-09-19 주식회사 하이헴프씨 Resonant containing hemp seed solids and it's preparation method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102443883B1 (en) * 2022-04-14 2022-09-19 주식회사 하이헴프씨 Resonant containing hemp seed solids and it's preparation method

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