KR20210050913A - Aqueous adhesive composition for medical adhesive and medical adhesive sheet using thereof - Google Patents

Abstract

The present invention relates to an aqueous adhesive composition including: a copolymer including a structural unit derived from one or two or more (meth)acrylic acid ester monomers (A), a structural unit derived from a crosslinkability imparting monomer (B), and a structural unit derived from a functional monomer (C); surfactants; and water.

Description

Aqueous adhesive composition used in medical adhesive fabric and medical adhesive sheet using the same {AQUEOUS ADHESIVE COMPOSITION FOR MEDICAL ADHESIVE AND MEDICAL ADHESIVE SHEET USING THEREOF}

The present invention relates to an aqueous pressure-sensitive adhesive composition used in a medical adhesive fabric, including a specific acrylic copolymer, a surfactant, and water, and a medical pressure-sensitive adhesive sheet using the same.

In the case of medical adhesive fabric, it is a widely used general medicine that many age groups adhere to the skin surface to produce anti-inflammatory and pain relief effects.

However, in the case of the adhesive used in the adhesive fabric, almost all oiliness has been used so far, and in the prior art, it relates to a medical patch that shows a decrease in drug effect and skin irritation by using a weakly basic functional group present in an oily acrylic block polymer. Although there is a patent (Patent Document 1), in the end, due to the organic solvent used as a solvent, some VOCs (volatile organic compounds) are exposed, deteriorating the health of workers, and causing various environmental problems due to a high risk of fire. In addition, the problem of causing skin irritation in some people due to the organic solvent partially remaining in the adhesive layer is also occurring occasionally.

As the industry gradually develops, environmental problems of workers and the risks of chemical raw materials used have recently emerged, and legal sanctions have been created and are currently being implemented. In the mass media, as the interest in safety has gradually increased, legal regulations on the use of organic solvents have gradually strengthened.Especially, in the case of medical adhesives used directly on the human body, skin irritation or VOCs (volatile organic compounds) emission problems have led to environmentally friendly products. The demand is increasing.

In order to overcome the above problems, many manufacturers have been spurring development for a long time to solve this problem with a water-based acrylic copolymer polymerization product precisely, but it is quite difficult in terms of coating properties because the solvent is water. Problems have not been improved, and there is a possibility that a surfactant required for synthesis may cause skin irritation, making it difficult to develop.

In the case of the current oil-based adhesive, the shape is in the form of a linear chain, and the surface tension is low, so the coating property and bonding strength with the substrate are also excellent.

On the other hand, in the case of water, the particle shape is dispersed in water, and each particle has a polymer in the aggregate of surfactants called micelles, and because the particles are in the form of particles, the adhesive is applied in a structure in which the particles are gathered and stacked. Compared to the form of oily property, the density of the film is lowered when forming the film, and the bonding strength with the substrate is significantly lowered. Even if the adhesive properties are synthesized equal to oil properties, the problem of separating from the substrate due to low coatability and substrate bonding force is frequently occurring, making it difficult to meet the required workability.

Korean Patent Publication No. 10-2018-0059870

Under such circumstances, the object of the present invention is that it has adhesive properties equivalent to the existing oily acrylic adhesives used in medical adhesives, and there is no skin irritation because VOCs (volatile organic compounds) are not detected by the solvent, and water is safer than oily water. A cosmetic ingredient or food that is harmless to skin irritation with a reactive surfactant (reactive surfactant with a double bond reactor) or some FDA approved, while securing coating properties while being able to prepare an aqueous adhesive by polymerization of an aqueous acrylic copolymer using It is to provide an aqueous pressure-sensitive adhesive composition that uses a special surfactant used in raw materials, secures the bonding strength of the substrate between the pressure-sensitive adhesive and the adhesive fabric, and replaces the oil-based adhesive fabric adhesive.

The present inventors are the structural units derived from one or two or more (meth)acrylic acid ester monomers (A), the structural units derived from the crosslinking imparting monomer (B), and the structural units derived from the functional monomer (C) A copolymer comprising a; Surfactants; And water; by using an aqueous pressure-sensitive adhesive composition containing; it was found that the above problems can be solved, and the present invention was completed.

Specifically, the present invention provides the following.

One) A structural unit derived from one or two or more (meth)acrylic acid ester monomers (A), a structural unit derived from a crosslinking-imparting monomer (B), and a structural unit derived from a functional monomer (C) coalescence;

Surfactants;

And water; Containing,

Water-based adhesive composition.

2) In 1), the monomer (A) is butyl (meth)acrylate, t-butyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, i-octyl (meth)acrylate, n-octyl (Meth) acrylate, ethyl (meth) acrylate, methyl (meth) acrylate, n-propyl (meth) acrylate, and one or two or more monomers selected from the group consisting of i-propyl (meth) acrylate Characterized in that, the aqueous pressure-sensitive adhesive composition.

3) In 1), the monomer (C) is tridecyl acrylate, stearyl acrylate, trimethylolpropane triacrylate, 2-hydroxypropyl (meth)acrylate, 2-hydroxyethyl (meth)acrylate , Diacetoneacrylamide, trimethylolpropane tri(meth)acrylate (TMPTA), acetoacetoxyethyl (meth)acrylate, allyl(meth)acrylate, diethyl glycol diacrylate, 1,6-hexanediol di An aqueous pressure-sensitive adhesive composition, characterized in that it is at least one selected from the group consisting of acrylate and tripropylene glycol diacrylate (TPGDA).

4) The aqueous pressure-sensitive adhesive composition according to 1), wherein the copolymer contains 0.1 to 10 parts by weight of the monomer (C) based on 100 parts by weight of the copolymer.

5) The aqueous pressure-sensitive adhesive composition according to 1), wherein the copolymer is in the form of particles having a particle diameter of 50 to 300 nm.

6) In 1), the surfactant is polyethylene alkylphenol ester, ammonium sulfate, ammonium persulfate, sodium lauryl sulfate, ammonium dodecyl benzene sulfonate, sulfosuccinate, sodium dioctyl sulfosulfoxynate, and sulfuric ester salt. , Polyoxyethylene alkyl ether, fatty acid sorbital ester, fatty acid diethanol amine, alkyl monoglyceryl ether, alkyl sulfate ester salt, alkyl polyoxyethylene sulfate, sodium polyoxyethylene alkyl ether sulfate and alpha olefin sulfonate Characterized in that selected, aqueous pressure-sensitive adhesive composition.

7) According to 1), characterized in that the surfactant is included in an amount of 0.5 to 5 parts by weight based on 100 parts by weight of the copolymer.

8) The aqueous pressure-sensitive adhesive composition according to 1), wherein the copolymer has a solid content of 50% by weight or more.

9) The aqueous adhesive composition according to any one of 1) to 8), wherein the composition is for a medical adhesive cloth adhesive.

10) A pressure-sensitive adhesive sheet containing the water-based pressure-sensitive adhesive composition according to any one of 1) to 8).

The present invention has the same adhesive properties as the existing oily acrylic adhesives used in medical adhesive fabrics, and there is no skin irritation because VOCs (volatile organic compounds) are not detected by the solvent, and an aqueous acrylic copolymer using water that is safer than oily A special interface used in cosmetic or food ingredients that is harmless to skin irritation, which is capable of manufacturing aqueous adhesives by polymerization, secures coating properties, and has a reactive surfactant (reactive surfactant with a double bond reactor) or partially approved by FDA. While using an activator, it is possible to provide an aqueous pressure-sensitive adhesive composition that secures a base bonding force between the pressure-sensitive adhesive and the adhesive fabric, and replaces the oil-based adhesive fabric.

1 shows crosslinking and density increase according to particle size control and use of a reactive emulsifier.

In the description in the present specification, for example, "(meth)acrylic acid" is used as a word representing both "acrylic acid" and "methacrylic acid", and the same applies to other similar terms.

Hereinafter, the aqueous pressure-sensitive adhesive composition of the present invention will be described.

The aqueous pressure-sensitive adhesive composition of the present invention is a structural unit derived from one or two or more (meth)acrylic acid ester monomers (A), a structural unit derived from a crosslinkable imparting monomer (B), and a functional monomer (C). A copolymer containing the derived structural unit; Surfactants; And water;

[Copolymer]

The copolymer of the present invention has a solid content of 50% by weight or more, that is, 50 to 100% by weight, preferably 50 to 65% by weight, and more preferably 50 to 60% by weight. If the solid content exceeds 65% by weight, the viscosity becomes too high and it is difficult to control the coating thickness.If the solid content is less than 50% by weight, the viscosity becomes too low and the coating property is significantly reduced when applied to a roll coater, so the solid content is reduced to 50 to 60% by weight. By applying the viscosity range of 4,000 ~ 6,000 cps, it is possible to secure coating properties.

The copolymer of the present invention may be in the form of particles, and in order to secure coatability, a particle diameter range of 50 to 300 nm, preferably 80 to 180 nm, may be used. When the particle diameter of the particles is less than 50 nm, the viscosity of the aqueous acrylic copolymer vehicle agent is too high to control the coating thickness, and when the particle diameter exceeds 300 nm, the stability decreases and layer separation occurs. As the void increases, the bonding force with the adhesive fabric substrate decreases. Therefore, it is preferable to synthesize the particles with a particle diameter of around 80 to 180 nm.

The distribution of the copolymer particles can be variously adjusted depending on the type of surfactant and the addition method of the pre-copolymer (copolymer used during the reaction). The method of controlling the particle distribution is as follows. In the case of undergoing an initial reaction as a part of the pre-copolymer, most of the particles are formed to have a similar size at this time, and polymerization is carried out in the resulting particles, so that the particle size is mostly constant and is synthesized regularly. However, when the main reaction is started without an initial reaction in order to form various types of particles, since it is initially formed in various particle types, the particle distribution can be broadened.

When the particle distribution value (PdI) is low, it is close to a uniform particle, and when it is high, it is composed of broadly various particle sizes. When the particle distribution is wide, the gap between the particles becomes narrower and the density increases, so that the particles become more closely adhered to each other during film formation and the coating property is improved. The particle distribution value (PdI) is preferably 0.006 to 0.05, more preferably 0.02 to 0.04.

The copolymer of the present invention is a structural unit derived from one or two or more (meth)acrylic acid ester monomers (A) (hereinafter also referred to as'monomers (A)'), a crosslinkable monomer (B) (hereinafter, A structural unit derived from a "monomer (B)") and a structural unit derived from a functional monomer (C) (hereinafter also referred to as a "monomer (C)") are included.

<(meth)acrylic acid ester monomer (A)>

The monomer (A) is not particularly limited, but may be a (meth)acrylic acid ester monomer having 1 to 18 carbon atoms, for example, butyl (meth)acrylate, t-butyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, hexylacrylate, i-octyl (meth)acrylate, n-octyl (meth)acrylate, ethyl (meth)acrylate, methyl (meth)acrylate, n-propyl ( It may be selected from the group consisting of meth)acrylate and i-propyl (meth)acrylate.

<Crosslinking imparting monomer (B)>

The monomer (B) may be included in the range of 0.1 to 15 parts by weight, preferably 0.5 to 3 parts by weight, based on 100 parts by weight of the copolymer. If the content of the crosslinking imparting monomer (B) is less than 0.1 parts by weight with respect to 100 parts by weight of the copolymer, the cohesive strength is lowered, and if the content is more than 15 parts by weight, the degree of crosslinking is too high, resulting in the formation of aggregates during the reaction or a significant increase in viscosity Occurs.

The monomer (B) is not particularly limited, but may be an acrylic monomer having 1 to 18 carbon atoms, and for example, acrylic acid, methacrylic acid, itaconic acid, maleic acid, formic acid, formic acid, acetic acid, etc. It can be used for one or two or more.

<functional monomer (C)>

The functional monomer (C) may be used in the copolymer in order to compensate for the lack of adhesion to the base material with the adhesive fabric. The functional group of the functional monomer (C) and the reactive group of the surfactant complement the bonding force between the adhesive fabric substrate.

The monomer (C) may be included in the range of 0.1 to 10 parts by weight, preferably 0.1 to 6 parts by weight, based on 100 parts by weight of the copolymer. If the content of the monomer (C) is too small, such as less than 0.1 parts by weight based on 100 parts by weight of the copolymer, the problem of transferring the adhesive to the skin occurs, and if it exceeds 10 parts by weight, the adhesive property deteriorates and the adhesive fabric itself As the adhesiveness of the adhesive decreases, a problem occurs in that the adhesive fabric is peeled off by itself, or a problem occurs in that the drug portion and the adhesive fabric portion are peeled off.

Although the monomer (C) is not particularly limited, for example, tridecyl acrylate, stearyl acrylate, trimethylolpropane triacrylate, 2-hydroxypropyl (meth)acrylate, 2-hydroxyethyl ( Meth)acrylate, diacetoneacrylamide, acetoacetoxy trimethylolpropane tri(meth)acrylate (TMPTA), acetoacetoxyethyl (meth)acrylate, allyl (meth)acrylate, diethyl glycol diacrylate, One or more selected from the group consisting of 1,6-hexanediol diacrylate and tripropylene glycol diacrylate (TPGDA), acrylamide, and glycidyl (meth)acrylate may be used.

[Surfactants]

The amount of the surfactant may be used in the range of 0.5 to 5 parts by weight based on 100 parts by weight of the copolymer, which is an optimal ratio, for stability, and more preferably in the range of 0.8 to 3.5 parts by weight.

As the surfactant, an anionic surfactant may be used alone, or one or two or more types may be used, and more preferably, an anionic surfactant and a nonionic surfactant may be used for synthesis.

Although it does not specifically limit as a surfactant, For example, polyethylene alkylphenol ester, ammonium sulfate, ammonium persulfate, sodium lauryl sulfate, ammonium dodecyl benzene sulfonate, sulfoxinate, sodium dioctyl sulfoxinate , Sulfate ester salt, polyoxyethylene alkyl ether, fatty acid sorbital ester, fatty acid diethanol amine, alkyl monoglyceryl ether, alkyl sulfate ester salt, alkyl polyoxyethylene sulfate, sodium polyoxyethylene alkyl ether sulfate, alpha olefin sulfonate Etc. can be used.

In addition, as a surfactant, a surfactant for cosmetics or food that is harmless to skin irritation is used, or a reactive surfactant (having a double bond group) is used to reduce voids through crosslinking between particles and the oil or water generated in the skin. By preventing the penetration of the branch, it can improve the change over time of the adhesive force.

More specifically, a reactive emulsifier containing one or more double bonds may be used. There are anionic and nonionic, wherein the anionic reactive emulsifiers are SR-10, SR-30, SR-1025, SR-1035 from Adeka, KH-05, KH-10, BC-05, BC-10, BC from Adeka There are -20, BC-30, PD-104 of KAO, etc. Nonionic reactive emulsifiers are ER-10, ER-20, ER-30, ER-40 of Adeka, RN-10, RN-20 of DKS , RN-30, and RN-50. In addition, it is possible to use eco-friendly reactive emulsifiers that are APE free or E-118B from KAO, which is used for transdermal applications such as cosmetics.

The range of viscosity of the final adhesive product is preferably within 2,000 to 8,000 cps, more preferably within 4,000 to 6,000 cps, and most preferably, when measured at 25° C. using a brookfeild LV Viscometer, the standard of oil roll coater. It is difficult to control the coating when it is over 8,000 cps.

Hereinafter, it will be described in detail through examples.

<Materials used>

KAO E-118B: Sodium polyoxyethylene alkyl ether sulfate

DKS Hitenol KH-10: Sodium polyoxyethylene alkyl ether sulfuric ester

ADEKA SR-10: Sodium polyoxyethylene alkyl ether sulfuric ester

SOLVAY DS-4: Sodium dodecyl (branched)benzene sulfonate

2-EHA: 2-ethylhexyl acrylate,

BA: butyl methacrylate

MMA: methyl methacrylate,

AA: acrylic acid,

EA: ethyl acrylate,

AAEM: acetoacetoxyethyl methacrylate

AMA: allyl methacrylate

TMPTA: trimethylolpropane triacrylate

APS: ammonium persulfate

<Example 1>

In a 3 liter glass reactor equipped with an alcohol thermometer, stirrer, dropping burette, nitrogen inlet tube, and reflux condenser, emulsify in the following composition at a reaction temperature of 84 ℃ to carry out an acrylic aqueous acrylic copolymer reaction by a semi-batch polymerization method. I did.

As a reactive anionic surfactant, 15g of Hitenol KH-10 from DKS was added, and 455g of distilled water was added, and after sufficiently stirring, 600g of BA, 400g of 2-EHA, 250g of MMA, 200g of EA, 15g of AAEM, 25g of AA were added. An acrylic copolymer was prepared. In addition, 3 g of KAO's E-118B and 500 g of distilled water were added to the reactor. 2 to 5% by weight of the total free aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water, and the initial reaction was carried out for 0.5 hours. Afterwards, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

After aging for 3 hours, after confirming unreacted odor, the reaction was terminated.

<Example 2>

As a reactive anionic surfactant, 15g of Hitenol KH-10 from DKS was added, and 455g of distilled water was added, and after sufficient stirring, 600g of BA, 400g of 2-EHA, 250g of MMA, 200g of EA, 15g of AMA, 25g of AA were added. An acrylic copolymer was prepared. In addition, 3 g of KAO's E-118B and 500 g of distilled water were added to the reactor. 2 to 5% by weight of the total free aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water, and the initial reaction was carried out for 0.5 hours. Afterwards, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

<Example 3>

For surfactant, 40g of KAO's E-118B was added as an anionic surfactant, 455g of distilled water was added, and after sufficient stirring, 600g of BA, 400g of 2-EHA, 250g of MMA, 200g of EA, 15g of AAEM and 25g of AA were added. I made a coalition. In addition, 3 g of KAO's E-118B and 500 g of distilled water were added to the reactor. 2 to 5% by weight of the total free aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water, and the initial reaction was carried out for 0.5 hours. Afterwards, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

<Example 4>

Surfactant uses a general anionic type, 30g of SOLVAY's DS-4 is added, 455g of distilled water is added, and after sufficient stirring, BA 600g, 2-EHA 400g, MMA 250g, EA 200g, AAEM 15g, AA 25g are added, and after sufficient stirring, free An aqueous acrylic copolymer was made. In addition, 3 g of KAO's E-118B and 500 g of distilled water were added to the reactor. 2 to 5% by weight of the total free aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water, and the initial reaction was carried out for 0.5 hours. Afterwards, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

<Example 5>

It was synthesized in the same manner as in Example 1 except for the initial reaction.

<Example 6>

Under the same conditions as in Example 1, 40g of Hitenol KH-10 from DKS was added as a reactive anionic surfactant, and 455g of distilled water was added, and after sufficiently stirring, 600g of BA, 400g of 2-EHA, 250g of MMA, 200g of EA, 15g of TMPTA, 25g of AA. After adding and sufficiently stirring, a free aqueous acrylic copolymer was prepared. In addition, 3 g of KAO's E-118B and 500 g of distilled water were added to the reactor. 2 to 5% by weight of the total free aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water, and the initial reaction was carried out for 0.5 hours. Afterwards, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 4.3 g of APS for 4 hours.

<Example 7>

As a reactive anionic surfactant, 15g of ADEKA's SR-10 was added, and 455g of distilled water was added, and after sufficient stirring, BA 600g, 2-EHA 400g, MMA 250g, EA 200g, AAEM 15g, and AA 25g were added. A copolymer was made. In addition, 3 g of KAO's E-118B and 1500 g of distilled water were added to the reactor. 2 to 5% by weight of the total free aqueous acrylic copolymer was first added, and 3 g of APS was added to 50 g of distilled water, and the initial reaction was carried out for 0.5 hours. Afterwards, 40 g of distilled water and the remaining amount of the free aqueous acrylic copolymer were added dropwise to 5.3 g of APS for 4 hours.

<Example 8>

In Example 1, 15 g of the reactive surfactant KH-10 was added, reduced to 5 g, and the remainder was synthesized in the same manner.

<Example 9>

It was synthesized in the same manner as in Example 7 except for the initial reaction.

<Comparative Example 1>

Organic solvent type medical adhesive currently on the market

In case of basic physical property test

One) The solid content was dried in a dry oven at 145 ℃ for 40 minutes and then weighed.

2) The viscosity was measured three times using a brookfield LV Viscometer and then expressed as an average.

3) In the case of pH, it was measured once using a Metrohm pH meter.

4) Coating properties:

(One) Coating method: Release paper (150mm X 300mm)

Dry 20 ㎛ after transfer coating (dry at 110℃ for 3 minutes), aging for 1 day of adherent paper

(2) Coating (5 ~ 1): 5: good

4: Observation of two pinholes

3: Observation of 2 to 4 pinholes

2: Observation of 5 to 8 pinholes

1: 9 or more pinholes

(3) Substrate bonding force: After making the coated specimen in 50 mm x 50 mm, remove the release paper, fold half so that the adhesive side sticks to each other, pin it again (repeated 10 times, check the peeled area), peeled part of the total area Is expressed in %.

In the case of adhesive properties

1) Peel strength

After cutting into a predetermined size, peel the release paper, attach it to a stainless steel plate (polished with SUS.304, Sand Paper #280) in a constant temperature and humidity room, and then reciprocate and press once with a 2 kg pressing roller.

After 20 minutes and 1 hour of pressing, the peel strength is measured in a tensile tester, respectively. (180 peel)

① Test material; Polyester film (25 ㎛) / stainless steel plate

② tensile distance; 300 mm/min

③ adhesion area; 25 mm × 40 mm or more

④ Weight and speed of compression roll; 2 kg, 300 mm/min, 1 round trip

2) Holding power (cohesive power of the adhesive itself)

The test piece is 25 mm wide and 55 mm long, and the test piece is attached to a stainless steel plate so that it has an area of 25 mm wide and 25 mm long, pressed from the top of the test piece with a compression roll, and left in a constant temperature and humidity room for 1 hour, and then in an environment at 60 ℃. Leave for 20 minutes. After that, apply a static load of 1 kg to the bottom and measure the time to fall of the adhesive surface.

① Test material; Polyester film (25 ㎛) / stainless steel plate

② measurement temperature; 60 ℃

③ fixed load; 1 kg

④ bonding area; 25 mm × 25 mm

⑤ measurement time; Time to fall after 60 minutes

⑥ Weight and speed of compression roll; 2 kg, 300 mm/min, 1 round trip

3) Initial adhesion (Ball Tack)

In accordance with the J.DOW law, the stopped ball number is displayed.

① Test material; Polyester film (25㎛) / stainless steel plate

② measurement conditions; 23±2 ℃, 50±5% RH

③ getaway distance; 50 mm

④ angle; 30˚

⑤ amount of coating; 25 ~ 30 ㎛

4) Particle size and particle distribution (PdI): Using Malvern particle size analyzer

[Table 1]

Example 5 as a result of conducting a skin irritation test on rabbits of the Korea Testing and Research Institute according to the GLP standard (2.5 X 2.5 cm ² ) mortality for 72 hours after applying the test substance to the back for 24 hours, general No abnormalities were observed for symptoms, weight change and skin irritation. According to Draize's evaluation method, the primary skin irritation index (PII) was calculated as “0.0” and was judged as a non-irritating substance.

Claims (10)

A structural unit derived from one or two or more (meth)acrylic acid ester monomers (A), a structural unit derived from a crosslinkable monomer (B), and a structural unit derived from a functional monomer (C) coalescence;
Surfactants;
And water; Containing,
Water-based adhesive composition. The method according to claim 1, wherein the monomer (A) is butyl (meth)acrylate, t-butyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, i-octyl (meth)acrylate, n- One or two or more monomers selected from the group consisting of octyl (meth)acrylate, ethyl (meth)acrylate, methyl (meth)acrylate, n-propyl (meth)acrylate, and i-propyl (meth)acrylate Characterized in that, the aqueous pressure-sensitive adhesive composition. The method according to claim 1, wherein the monomer (C) is tridecyl acrylate, stearyl acrylate, trimethylolpropane triacrylate, 2-hydroxypropyl (meth)acrylate, and 2-hydroxyethyl (meth)acrylic. Rate, diacetoneacrylamide, trimethylolpropane tri(meth)acrylate (TMPTA), acetoacetoxyethyl (meth)acrylate, allyl(meth)acrylate, diethyl glycol diacrylate, 1,6-hexanediol Diacrylate and tripropylene glycol diacrylate (TPGDA), characterized in that at least one selected from the group consisting of, the aqueous pressure-sensitive adhesive composition. The aqueous pressure-sensitive adhesive composition according to claim 1, wherein the copolymer contains 0.1 to 10 parts by weight of the monomer (C) based on 100 parts by weight of the copolymer. The aqueous pressure-sensitive adhesive composition according to claim 1, wherein the copolymer is in the form of particles having a particle diameter of 50 to 300 nm. 2. Salt, polyoxyethylene alkyl ether, fatty acid sorbital ester, fatty acid diethanol amine, alkyl monoglyceryl ether, alkyl sulfate ester salt, alkyl polyoxyethylene sulfate, sodium polyoxyethylene alkyl ether sulfate and alpha olefin sulfonate Characterized in that selected from, the aqueous pressure-sensitive adhesive composition. The aqueous pressure-sensitive adhesive composition of claim 1, wherein the surfactant is included in an amount of 0.5 to 5 parts by weight based on 100 parts by weight of the copolymer. The aqueous pressure-sensitive adhesive composition according to claim 1, wherein the copolymer has a solid content of 50% by weight or more. The aqueous adhesive composition according to any one of claims 1 to 8, wherein the composition is for a medical adhesive cloth adhesive. A pressure-sensitive adhesive sheet containing the aqueous pressure-sensitive adhesive composition according to any one of claims 1 to 8.

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